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Tatsuro Misu

Section

Tohoku University Hospital

Job title

Specially Appointed Professor(Research)

Degree

博士（医学）（東北大学）

researchmap

https://researchmap.jp/read0131484

J-GLOBAL ID

200901019777414764

Research History 9

2024/04 - Present

Tohoku University Hospital　Department of Clinical Research Implementation, Clinical Research, Innovation and Education Center,　Special appointment Professor
2019/05 - 2024/03

東北大学病院脳神経内科講師
2017/03 - 2019/04

東北大学大学院医学系研究科多発性硬化症治療学寄付講座講師
2007/05 - 2017/02

東北大学大学院医学系研究科多発性硬化症治療学寄付講座助教
2005/10 - 2007/04

東北大学病院助手
2003/04 - 2005/09

東北大学病院医員
1998/10 - 1999/03

山形市立病院済生館神経内科
1998/04 - 1998/09

財団法人広南会広南病院神経内科研修医
1997/04 - 1998/03

Resident, Department of Neurology, Tohoku University Hospital

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Education 2

Department of Neurology, Tohoku University Graduate School of Medicine

1999/04 - 2003/03
Faculty of medicine, Hirosaki university

1991/04 - 1997/03

Committee Memberships 4

Japanese Society of Neurology　Delegate

2025/04 - Present
日本神経治療学会　評議員

2024/11 - Present
日本神経病理学会　代議員

2019/01 - Present
日本神経免疫学会　評議員

2009/01 - Present

Research Interests 10

experimental autoimmune encephalomyelitis
myelin oligodendrocyte glycoprotein antibody
aquaporin 4 antibody
autoimmune disease
demyelinating disease
astrocytopathy
神経内科学
神経変性疾患
multiple sclerosis
Neuromyelitis optica

Research Areas 1

Life sciences / Neurology /

Awards 4

Best Presentation Poster Award

2013　European Comittee of Treatment and Research in Multiple Sclerosis (ECTRIMS)
Best Presentation Award

2008　Pan-Asian Comittee of Research and Treatment in Multiple Sclerosis (PACTRIM)
日本神経免疫学会賞

2007/04/13　日本神経免疫学会　視神経脊髄炎NMOの病理学的検討―アクアポリン4、アストログリアを起因とする疾患群
Young Neuroimmunologist Award

2005/03　日本神経免疫学会

Papers 201

The real-world impact of biologics for NMOSD: A retrospective single-center study compared with natural course and conventional treatments in Japanese

Naoya Yamazaki, Tatsuro Misu, Yuki Matsumoto, Yoshiki Takai, Chihiro Namatame, Hirohiko Ono, Kimihiko Kaneko, Shuhei Nishiyama, Hiroshi Kuroda, Toshiyuki Takahashi, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki

Multiple Sclerosis and Related Disorders　92　106176-106176　2024/12
Publisher: Elsevier BV
DOI： 10.1016/j.msard.2024.106176 　

ISSN： 2211-0348
Different Complement Activation Patterns Following C5 Cleavage in MOGAD and AQP4-IgG+NMOSD. International-journal

Kimihiko Kaneko, Hiroshi Kuroda, Yuki Matsumoto, Naohiro Sakamoto, Naoya Yamazaki, Naoki Yamamoto, Shu Umezawa, Chihiro Namatame, Hirohiko Ono, Yoshiki Takai, Toshiyuki Takahashi, Juichi Fujimori, Ichiro Nakashima, Yasuo Harigaya, Hans Lassmann, Kazuo Fujihara, Tatsuro Misu, Masashi Aoki

Neurology(R) neuroimmunology & neuroinflammation　11　(5)　e200293　2024/09

DOI： 10.1212/NXI.0000000000200293 　

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OBJECTIVES: In myelin oligodendrocyte glycoprotein IgG-associated disease (MOGAD) and aquaporin-4 IgG+ neuromyelitis optica spectrum disorder (AQP4+NMOSD), the autoantibodies are mainly composed of IgG1, and complement-dependent cytotoxicity is a primary pathomechanism in AQP4+NMOSD. We aimed to evaluate the CSF complement activation in MOGAD. METHODS: CSF-C3a, CSF-C4a, CSF-C5a, and CSF-C5b-9 levels during the acute phase before treatment in patients with MOGAD (n = 12), AQP4+NMOSD (n = 11), multiple sclerosis (MS) (n = 5), and noninflammatory neurologic disease (n = 2) were measured. RESULTS: CSF-C3a and CSF-C5a levels were significantly higher in MOGAD (mean ± SD, 5,629 ± 1,079 pg/mL and 2,930 ± 435.8 pg/mL) and AQP4+NMOSD (6,017 ± 3,937 pg/mL and 2,544 ± 1,231 pg/mL) than in MS (1,507 ± 1,286 pg/mL and 193.8 ± 0.53 pg/mL). CSF-C3a, CSF-C4a, and CSF-C5a did not differ between MOGAD and AQP4+NMOSD while CSF-C5b-9 (membrane attack complex, MAC) levels were significantly lower in MOGAD (17.4 ± 27.9 ng/mL) than in AQP4+NMOSD (62.5 ± 45.1 ng/mL, p = 0.0019). Patients with MOGAD with severer attacks (Expanded Disability Status Scale [EDSS] ≥ 3.5) had higher C5b-9 levels (34.0 ± 38.4 ng/m) than those with milder attacks (EDSS ≤3.0, 0.9 ± 0.7 ng/mL, p = 0.044). DISCUSSION: The complement pathway is activated in both MOGAD and AQP4+NMOSD, but MAC formation is lower in MOGAD, particularly in those with mild attacks, than in AQP4+NMOSD. These findings may have pathogenetic and therapeutic implications in MOGAD.
Myelin oligodendrocyte glycoprotein antibody‐associated disorders: An overview

Tatsuro Misu, Yuki Matsumoto, Kimihiko Kaneko, Toshiyuki Takahashi, Yoshiki Takai, Hirohiko Ono, Chihiro Namatame, Shuhei Nishiyama, Juichi Fujimori, Hiroshi Kuroda, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki

Clinical and Experimental Neuroimmunology　2023/12/19
Publisher: Wiley
DOI： 10.1111/cen3.12771 　

ISSN： 1759-1961

eISSN： 1759-1961

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Abstract In recent years, there is growing evidence of associations between antibodies against myelin oligodendrocyte glycoprotein (MOG) and several phenotypes of acute inflammatory demyelinating diseases such as acute disseminated encephalomyelitis (ADEM), optic neuritis, brainstem, and cerebral cortical encephalitis, called MOG antibody associated disorders (MOGAD). Monophasic course is known in about half of cases especially in pediatric onset ADEM and optic neuritis, mainly in cases with transient positivity of MOG antibody. Pathological features of MOGAD are considered as acute demyelinating lesions with CD4 dominant cell infiltrations, the deposition of humoral immunity, perivascular inflammation and perivenous demyelination, which is distinct from multiple sclerosis. Now the diagnosis of MOGAD is based on the international panel criteria of MOGAD launched in 2023, which the diagnostic frameworks are three parts, including MOGAD‐specific clinical features, MOG antibody positivity, and the exclusion of other diseases. The prognosis of MOGAD patients is considered relatively mild, but the problem is refractory relapsing cases. For its prevention, there are no approved drugs, but oral tapering corticosteroids, immunosuppressants such as azathioprine and mycophenolic mofetil, rituximab, and the maintenance intravenous immunoglobulin are recommended, and now there are a few clinical trials of promising biological drugs already approved in other neurological disorders.
Diagnostic implications of MOG-IgG detection in sera and cerebrospinal fluids. International-journal

Yuki Matsumoto, Kimihiko Kaneko, Toshiyuki Takahashi, Yoshiki Takai, Chihiro Namatame, Hiroshi Kuroda, Tatsuro Misu, Kazuo Fujihara, Masashi Aoki

Brain : a journal of neurology　146　(9)　3938-3948　2023/04/15

DOI： 10.1093/brain/awad122 　

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The spectrum of myelin oligodendrocyte glycoprotein (MOG)-IgG-associated disease (MOGAD) includes optic neuritis (ON), myelitis (MY), acute disseminated encephalomyelitis (ADEM), brainstem encephalitis, cerebral cortical encephalitis (CE), and aquaporin-4-IgG (AQP4-IgG)-negative neuromyelitis optica spectrum disorder (NMOSD). In MOGAD, MOG-IgG are usually detected in sera (MOG-IgGSERUM), but there have been some seronegative MOGAD cases with MOG-IgG in CSF (MOG-IgGCSF) and its diagnostic implications remains unclear. In this cross-sectional study, we identified patients with paired serum and CSF sent from all over Japan for testing MOG-IgG. Two investigators blinded to MOG-IgG status classified them into suspected MOGAD (ADEM, CE, NMOSD, ON, MY and Others) or not based on the current recommendations. The MOG-IgGSERUM and MOG-IgGCSF titres were assessed with serial two-fold dilutions to determine endpoint titres [≥1:128 in serum and ≥1:1 (no dilution) in CSF were considered positive]. We analysed the relations between MOG-IgGSERUM, MOG-IgGCSF, and the phenotypes with multivariable regression. A total of 671 patients were tested (405 with suspected MOGAD, 99 with multiple sclerosis, 48 with AQP4-IgG-positive NMOSD, and 119 with other neurological diseases [OND]) before treatment. In suspected MOGAD, 133 patients (33%) tested MOG-IgG-positive in serum and/or CSF; 94 (23%) double-positive (ADEM 36, CE 15, MY 8, NMOSD 9, ON 15, and Others 11), 17 (4.2%) serum-restricted-positive (ADEM 2, CE 0, MY 3, NMOSD 3, ON 5, and Others 4), and 22 (5.4%) CSF-restricted-positive (ADEM 3, CE 4, MY 6, NMOSD 2, ON 0, and Others 7) cases. None of AQP4-IgG-positive NMOSD, multiple sclerosis, or OND cases tested positive for MOG-IgGSERUM but two with multiple sclerosis were MOG-IgGCSF-positive; the specificity of MOG-IgGSERUM and MOG-IgGCSF in suspected MOGAD were 100% (95%CI 99%-100%) and 99% (97%-100%), respectively. Unlike AQP4-IgG-positive NMOSD, the correlation between MOG-IgGSERUM and MOG-IgGCSF titres in MOGAD was weak. Multivariable regression analyses revealed MOG-IgGSERUM were associated with ON and ADEM, whereas MOG-IgGCSF were associated with ADEM and CE. The number needed to test (NNT) of MOG-IgGCSF to diagnose one additional MOGAD case was 13.3 (14.3 for ADEM, 2 for CE, 19.5 for NMOSD, infinite for ON, 18.5 for MY, and 6.1 for Others). In the status of MOG-IgGSERUM/CSF, most cases were double-positive, while including either serum-restricted (13%) or CSF-restricted (17%). These statuses were independently associated with clinical phenotypes, especially with ON in serum and CE in CSF, suggesting these pathophysiologic implications and the utility of preferential diagnostic testing. Further studies are warranted for the clinical and pathological significance of compartmentalized MOG-IgG.
Compassionate open-label use of rituximab following a randomised clinical trial against neuromyelitis optica (RIN-2 study): B cell monitoring-based administration

Masayuki Tahara, Tomoko Oeda, Kazumasa Okada, Kazuhide Ochi, Hirofumi Maruyama, Hikoaki Fukaura, Kyoichi Nomura, Yuko Shimizu, Ichiro Nakashima, Tatsuro Misu, Atsushi Umemura, Kenji Yamamoto, Hideyuki Sawada

Multiple Sclerosis and Related Disorders　60　103730-103730　2022/04
Publisher: Elsevier BV
DOI： 10.1016/j.msard.2022.103730 　

ISSN： 2211-0348
GRP78 Antibodies Are Associated With Blood-Brain Barrier Breakdown in Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder. International-journal

Fumitaka Shimizu, Ryo Ogawa, Yoichi Mizukami, Kenji Watanabe, Kanako Hara, Chihiro Kadono, Toshiyuki Takahashi, Tatsuro Misu, Yukio Takeshita, Yasuteru Sano, Miwako Fujisawa, Toshihiko Maeda, Ichiro Nakashima, Kazuo Fujihara, Takashi Kanda

Neurology(R) neuroimmunology & neuroinflammation　9　(1)　2022/01

DOI： 10.1212/NXI.0000000000001038 　

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BACKGROUND AND OBJECTIVES: To analyze (1) the effect of immunoglobulin G (IgG) from patients with anti-myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-associated disorder on the blood-brain barrier (BBB) endothelial cells and (2) the positivity of glucose-regulated protein 78 (GRP78) antibodies in MOG-Ab-associated disorders. METHODS: IgG was purified from sera with patients with MOG-Ab-associated disorder in the acute phase (acute MOG, n = 15), in the stable stage (stable MOG, n = 14), healthy controls (HCs, n = 9), and disease controls (DCs, n = 27). Human brain microvascular endothelial cells (BMECs) were incubated with IgG, and the number of nuclear NF-κB p65-positive cells in BMECs using high-content imaging system and the quantitative messenger RNA change in gene expression over the whole transcriptome using RNA-seq were analyzed. GRP78 antibodies from patient IgGs were detected by Western blotting. RESULTS: IgG in the acute MOG group significantly induced the nuclear translocation of NF-κB and increased the vascular cell adhesion molecule 1/intercellular adhesion molecule 1 expression/permeability of 10-kDa dextran compared with that from the stable MOG and HC/DC groups. RNA-seq and pathway analysis revealed that NF-κB signaling and oxidative stress (NQO1) play key roles. The NQO1 and Nrf2 protein amounts were significantly decreased after exposure to IgG in the acute MOG group. The rate of GRP78 antibody positivity in the acute MOG group (10/15, 67% [95% confidence interval, 38%-88%]) was significantly higher than that in the stable MOG group (5/14, 36% [13%-65%]), multiple sclerosis group (4/29, 14% [4%-32%]), the DCs (3/27, 11% [2%-29%]), or HCs (0/9, 0%). Removal of GRP78 antibodies from MOG-IgG reduced the effect on NF-κB nuclear translocation and increased permeability. DISCUSSION: GRP78 antibodies may be associated with BBB dysfunction in MOG-Ab-associated disorder.
Anti-NXP2 antibody-positive dermatomyositis developed after COVID-19 manifesting as type I interferonopathy. International-journal

Yuri Okada, Rumiko Izumi, Tatsuhiko Hosaka, Satoshi Watanabe, Tomomi Shijo, Naokazu Hatchome, Risa Konishi, Yuki Ichimura, Naoko Okiyama, Naoki Suzuki, Tatsuro Misu, Masashi Aoki

Rheumatology (Oxford, England)　61　(4)　e90-e92　2021/11/30

DOI： 10.1093/rheumatology/keab872 　
Difference in the Source of Anti-AQP4-IgG and Anti-MOG-IgG Antibodies in CSF in Patients With Neuromyelitis Optica Spectrum Disorder. International-journal

Tetsuya Akaishi, Toshiyuki Takahashi, Tatsuro Misu, Kimihiko Kaneko, Yoshiki Takai, Shuhei Nishiyama, Ryo Ogawa, Juichi Fujimori, Tadashi Ishii, Masashi Aoki, Kazuo Fujihara, Ichiro Nakashima

Neurology　97　(1)　e1-e12　2021/07/06

DOI： 10.1212/WNL.0000000000012175 　

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OBJECTIVE: To elucidate the differences in the source and in the level of intrathecal synthesis between anti-aquaporin-4 antibodies (AQP4-IgG) and anti-myelin oligodendrocyte glycoprotein antibodies (MOG-IgG). METHODS: Thirty-eight patients with MOG-IgG-associated disease and 36 with AQP4-IgG-positive neuromyelitis optica spectrum disorders (NMOSD) were studied for the antibody titers in the sera and CSF simultaneously collected in the acute attacks. The quotients between CSF and serum levels of albumin, total immunoglobulin G, and each disease-specific antibody were calculated. Intrathecal production level in each disease-specific antibody was evaluated by calculating the antibody index from these quotients. RESULTS: Eleven of the 38 patients with MOG-IgG were positive for the antibody only in the CSF, while no patient with AQP4-IgG showed CSF-restricted AQP4-IgG. Blood-brain barrier compromise as shown by raised albumin quotients was seen in 75.0% of MOG-IgG-positive cases and 43.8% of AQP4-IgG-positive cases. Moreover, MOG-IgG quotients were >10 times higher than AQP4-IgG quotients (effect size r = 0.659, p < 0.0001). Elevated antibody index (>4.0) was confirmed in 12 of 21 with MOG-IgG, whereas it was seen only in 1 of 16 with AQP4-IgG (φ = 0.528, p < 0.0001). The CSF MOG-IgG titers (ρ = 0.519, p = 0.001) and antibody indexes for MOG-IgG (ρ = 0.472, p = 0.036) correlated with the CSF cell counts but not with clinical disability. CONCLUSIONS: Intrathecal production of MOG-IgG may occur more frequently than that of AQP4-IgG. This finding implies the different properties of B-cell trafficking and antibody production between MOG-IgG-associated disease and AQP4-IgG-positive NMOSD.
Staging of astrocytopathy and complement activation in neuromyelitis optica spectrum disorders

Yoshiki Takai, Tatsuro Misu, Hiroyoshi Suzuki, Toshiyuki Takahashi, Hiromi Okada, Shinya Tanaka, Kenji Okita, Shunichi Sasou, Mika Watanabe, Chihiro Namatame, Yuki Matsumoto, Hirohiko Ono, Kimihiko Kaneko, Shuhei Nishiyama, Hiroshi Kuroda, Ichiro Nakashima, Hans Lassmann, Kazuo Fujihara, Yasuto Itoyama, Masashi Aoki

Brain　2021/03/12
Publisher: Oxford University Press (OUP)
DOI： 10.1093/brain/awab102 　

ISSN： 0006-8950

eISSN： 1460-2156

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<title>Abstract</title> Aquaporin 4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorder (AQP4-IgG+NMOSD) is an autoimmune astrocytopathic disease pathologically characterized by the massive destruction and regeneration of astrocytes with diverse types of tissue injury with or without complement deposition. However, it is unknown whether this diversity is derived from differences in pathological processes or temporal changes. Furthermore, unlike for the demyelinating lesions in multiple sclerosis, there has been no staging of astrocytopathy in AQP4-IgG+NMOSD based on astrocyte morphology. Therefore, we classified astrocytopathy of the disease by comparing the characteristic features, such as AQP4 loss, inflammatory cell infiltration, complement deposition and demyelination activity, with the clinical phase. We performed histopathological analyses in eight autopsied cases of AQP4-IgG+NMOSD. There were six women and two men, with a median age of 56.5 years (range, 46–71 years) and a median disease duration of 62.5 months (range, 0.6–252 months). Astrocytopathy in AQP4-IgG+NMOSD was classified into the following four stages defined by the astrocyte morphology and immunoreactivity for glial fibrillary acidic protein (GFAP): (a) astrocyte lysis: Extensive loss of astrocytes with fragmented and/or dust-like particles; (b) progenitor recruitment: Loss of astrocytes except small nucleated cells with GFAP-positive fibre-forming foot processes; (c) protoplasmic gliosis: Presence of star-shaped astrocytes with abundant GFAP-reactive cytoplasm; and (d) fibrous gliosis: Lesions composed of densely packed mature astrocytes. The astrocyte lysis and progenitor recruitment stages dominated in clinically acute cases (within 2 months after the last recurrence). Findings common to both stages were the loss of AQP4, a decreased number of oligodendrocytes, the selective loss of myelin-associated glycoprotein and active demyelination with phagocytic macrophages. The infiltration of polymorphonuclear cells and T cells (CD4-dominant) and the deposition of activated complement (C9neo), which reflects the membrane attack complex, a hallmark of acute NMOSD lesions, were selectively observed in the astrocyte lysis stage (98.4% in astrocyte lysis, 1.6% in progenitor recruitment, and 0% in protoplasmic gliosis and fibrous gliosis). Although most of the protoplasmic gliosis and fibrous gliosis lesions were accompanied by inactive demyelinated lesions with a low amount of inflammatory cell infiltration, the deposition of complement degradation product (C3d) was observed in all four stages, even in fibrous gliosis lesions, suggesting the past or chronic occurrence of complement activation, which is a useful finding to distinguish chronic lesions in NMOSD from those in multiple sclerosis. Our staging of astrocytopathy is expected to be useful for understanding the unique temporal pathology of AQP4-IgG+NMOSD.
Distinctive lesions of brain MRI between MOG-antibody-associated and AQP4-antibody-associated diseases. International-journal

Yuki Matsumoto, Tatsuro Misu, Shunji Mugikura, Yoshiki Takai, Shuhei Nishiyama, Hiroshi Kuroda, Toshiyuki Takahashi, Juichi Fujimori, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki

Journal of neurology, neurosurgery, and psychiatry　2020/12/30

DOI： 10.1136/jnnp-2020-324818 　
Myelin oligodendrocyte glycoprotein antibody-associated disease: an immunopathological study. International-journal Peer-reviewed

Yoshiki Takai, Tatsuro Misu, Kimihiko Kaneko, Norio Chihara, Koichi Narikawa, Satoko Tsuchida, Hiroya Nishida, Takashi Komori, Morinobu Seki, Teppei Komatsu, Kiyotaka Nakamagoe, Toshimasa Ikeda, Mari Yoshida, Toshiyuki Takahashi, Hirohiko Ono, Shuhei Nishiyama, Hiroshi Kuroda, Ichiro Nakashima, Hiroyoshi Suzuki, Monika Bradl, Hans Lassmann, Kazuo Fujihara, Masashi Aoki

Brain : a journal of neurology　2020/05/15

DOI： 10.1093/brain/awaa102 　

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Conformation-sensitive antibodies against myelin oligodendrocyte glycoprotein (MOG) are detectable in patients with optic neuritis, myelitis, opticomyelitis, acute or multiphasic disseminated encephalomyelitis (ADEM/MDEM) and brainstem/cerebral cortical encephalitis, but are rarely detected in patients with prototypic multiple sclerosis. So far, there has been no systematic study on the pathological relationship between demyelinating lesions and cellular/humoral immunity in MOG antibody-associated disease. Furthermore, it is unclear whether the pathomechanisms of MOG antibody-mediated demyelination are similar to the demyelination patterns of multiple sclerosis, neuromyelitis optica spectrum disorders (NMOSD) with AQP4 antibody, or ADEM. In this study, we immunohistochemically analysed biopsied brain tissues from 11 patients with MOG antibody-associated disease and other inflammatory demyelinating diseases. Patient median onset age was 29 years (range 9-64), and the median interval from attack to biopsy was 1 month (range 0.5-96). The clinical diagnoses were ADEM (n = 2), MDEM (n = 1), multiple brain lesions without encephalopathy (n = 3), leukoencephalopathy (n = 3) and cortical encephalitis (n = 2). All these cases had multiple/extensive lesions on MRI and were oligoclonal IgG band-negative. Most demyelinating lesions in 10 of 11 cases showed a perivenous demyelinating pattern previously reported in ADEM (153/167 lesions) and a fusion pattern (11/167 lesions) mainly in the cortico-medullary junctions and white matter, and only three lesions in two cases showed confluent demyelinated plaques. In addition, 60 of 167 demyelinating lesions (mainly in the early phase) showed MOG-dominant myelin loss, but relatively preserved oligodendrocytes, which were distinct from those of AQP4 antibody-positive NMOSD exhibiting myelin-associated glycoprotein-dominant oligodendrogliopathy. In MOG antibody-associated diseases, MOG-laden macrophages were found in the perivascular spaces and demyelinating lesions, and infiltrated cells were abundant surrounding multiple blood vessels in and around the demyelinating lesions, mainly consisting of macrophages (CD68; 1814 ± 1188 cells/mm2), B cells (CD20; 468 ± 817 cells/mm2), and T cells (CD3; 2286 ± 1951 cells/mm2), with CD4-dominance (CD4+ versus CD8+; 1281 ± 1196 cells/mm2 versus 851 ± 762 cells/mm2, P < 0.01). Humoral immunity, evidenced by perivascular deposits of activated complements and immunoglobulins, was occasionally observed in some MOG antibody-associated demyelinating lesions, and the frequency was much lower than that in AQP4 antibody-positive NMOSD. Subpial lesions with perivenous demyelination were observed in both ADEM and cortical encephalitis. Our study suggests that ADEM-like perivenous inflammatory demyelination with MOG-dominant myelin loss is a characteristic finding of MOG antibody-associated disease regardless of whether the diagnostic criteria of ADEM are met. These pathological features are clearly different from those of multiple sclerosis and AQP4 antibody-positive NMOSD, suggesting an independent autoimmune demyelinating disease entity.
Safety and efficacy of rituximab in neuromyelitis optica spectrum disorders (RIN-1 study): a multicentre, randomised, double-blind, placebo-controlled trial. International-journal Peer-reviewed

Masayuki Tahara, Tomoko Oeda, Kazumasa Okada, Takao Kiriyama, Kazuhide Ochi, Hirofumi Maruyama, Hikoaki Fukaura, Kyoichi Nomura, Yuko Shimizu, Masahiro Mori, Ichiro Nakashima, Tatsuro Misu, Atsushi Umemura, Kenji Yamamoto, Hideyuki Sawada

The Lancet. Neurology　19　(4)　298-306　2020/04

DOI： 10.1016/S1474-4422(20)30066-1 　

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BACKGROUND: Pharmacological prevention against relapses in patients with neuromyelitis optica spectrum disorder (NMOSD) is developing rapidly. We aimed to investigate the safety and efficacy of rituximab, an anti-CD20 monoclonal antibody, against relapses in patients with NMOSD. METHODS: We did a multicentre, randomised, double-blind, placebo-controlled clinical trial at eight hospitals in Japan. Patients aged 16-80 years with NMOSD who were seropositive for aquaporin 4 (AQP4) antibody, were taking 5-30 mg/day oral steroids, and had an Expanded Disability Status Scale (EDSS) score of 7·0 or less were eligible for the study. Individuals taking any other immunosuppressants were excluded. Participants were randomly allocated (1:1) either rituximab or placebo by a computer-aided dynamic random allocation system. The doses of concomitant steroid (converted to equivalent doses of prednisolone) and relapses in previous 2 years were set as stratification factors. Participants and those assessing outcomes were unaware of group assignments. Rituximab (375 mg/m2) was administered intravenously every week for 4 weeks, then 6-month interval dosing was done (1000 mg every 2 weeks, at 24 weeks and 48 weeks after randomisation). A matching placebo was administered intravenously. Concomitant oral prednisolone was gradually reduced to 2-5 mg/day, according to the protocol. The primary outcome was time to first relapse within 72 weeks. Relapses were defined as patient-reported symptoms or any new signs consistent with CNS lesions and attributable objective changes in MRI or visual evoked potential. The primary analysis was done in the full analysis set (all randomly assigned patients) and safety analyses were done in the safety analysis set (all patients who received at least one infusion of assigned treatment). The primary analysis was by intention-to-treat principles. This trial is registered with the UMIN clinical trial registry, UMIN000013453. FINDINGS: Between May 10, 2014, and Aug 15, 2017, 38 participants were recruited and randomly allocated either rituximab (n=19) or placebo (n=19). Three (16%) patients assigned rituximab discontinued the study and were analysed as censored cases. Seven (37%) relapses occurred in patients allocated placebo and none were recorded in patients assigned rituximab (group difference 36·8%, 95% CI 12·3-65·5; log-rank p=0·0058). Eight serious adverse events were recorded, four events in three (16%) patients assigned rituximab (lumbar compression fracture and infection around nail of right foot [n=1], diplopia [n=1], and uterine cancer [n=1]) and four events in two (11%) people allocated to placebo (exacerbation of glaucoma and bleeding in the right eye chamber after surgery [n=1], and visual impairment and asymptomatic white matter brain lesion on MRI [n=1]); all patients recovered. No deaths were reported. INTERPRETATION: Rituximab prevented relapses for 72 weeks in patients with NMOSD who were AQP4 antibody-positive. This study is limited by its small sample size and inclusion of participants with mild disease activity. However, our results suggest that rituximab could be useful maintenance therapy for individuals with NMOSD who are AQP4 antibody-positive. FUNDING: Japanese Ministry of Health, Labour and Welfare, Japan Agency for Medical Research and Development, and Zenyaku Kogyo.
Perivenous demyelination: Association with anti-myelin oligodendrocyte glycoprotein antibody

Tatsuro Misu, Yoshiki Takai, Toshiyuki Takahashi, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki

Clinical and Experimental Neuroimmunology　11　(S1)　22-27　2020/03/01

DOI： 10.1111/cen3.12569 　

eISSN： 1759-1961
Outcome prediction models in AQP4-IgG positive neuromyelitis optica spectrum disorders. Peer-reviewed

Palace J, Lin DY, Zeng D, Majed M, Elsone L, Hamid S, Messina S, Misu T, Sagen J, Whittam D, Takai Y, Leite MI, Weinshenker B, Cabre P, Jacob A, Nakashima I, Fujihara K, Pittock SJ

Brain : a journal of neurology　142　(5)　1310-1323　2019/05

DOI： 10.1093/brain/awz054 　

ISSN： 0006-8950
Circulating AQP4-specific auto-antibodies alone can induce neuromyelitis optica spectrum disorder in the rat. Peer-reviewed

Hillebrand S, Schanda K, Nigritinou M, Tsymala I, Böhm D, Peschl P, Takai Y, Fujihara K, Nakashima I, Misu T, Reindl M, Lassmann H, Bradl M

Acta neuropathologica　137　(3)　467-485　2019/03

DOI： 10.1007/s00401-018-1950-8 　

ISSN： 0001-6322
Area postrema syndrome: Frequency, criteria, and severity in AQP4-IgG-positive NMOSD. International-journal Peer-reviewed

Eslam Shosha, Divyanshu Dubey, Jacqueline Palace, Ichiro Nakashima, Anu Jacob, Kazuo Fujihara, Toshiyuki Takahashi, Daniel Whittam, Maria Isabel Leite, Tatsuro Misu, Takai Yoshiki, Silvia Messina, Liene Elsone, Masoud Majed, Eoin Flanagan, Avi Gadoth, Carey Huebert, Jessica Sagen, Benjamin M Greenberg, Michael Levy, Aditya Banerjee, Brian Weinshenker, Sean J Pittock

Neurology　91　(17)　e1642-e1651-e1651　2018/10/23

DOI： 10.1212/WNL.0000000000006392 　

ISSN： 0028-3878

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OBJECTIVE: To define the frequency, duration, and severity of intractable nausea, vomiting, or hiccups in aquaporin-4-immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica spectrum disorder (NMOSD) and propose diagnostic criteria and a severity scale for area postrema syndrome (APS). METHODS: An International NMOSD database was interrogated for frequency of APS. Patients with AQP4-IgG-positive NMOSD completed an APS symptom questionnaire. Nausea and vomiting severity was derived from the Pregnancy-Unique Quantification of Emesis and Nausea (PUQE) score. The diagnostic criteria, severity scale, and immunotherapy response was applied to a prospective validation cohort of patients from multiple centers. RESULTS: Analysis of an international database for AQP4-IgG-seropositive NMOSD (n = 430) revealed a high prevalence of isolated APS attacks (onset 7.1%-10.3%; subsequent 9.4%-14.5%) across continents. For 100 patients with 157 episodes of APS, nausea (n = 127, 81%) lasted for a median of 14 days (range 2-365), vomiting (113, 72%) with a median of 5 episodes/d (2-40) lasted 1-20 minutes, and hiccups (102, 65%) lasted a median of 14 days (2-365). Symptoms consistently and completely resolved following immunotherapy. Data were used to propose APS diagnostic criteria and repurpose PUQE score (hiccups severity grade based on symptom duration). The clinical utility was demonstrated in a prospective validation cohort. CONCLUSION: Isolated APS attacks are frequently encountered both at onset and during the NMOSD course. The diagnostic criteria proposed here will assist clinicians in recognizing APS. Diagnosis of an APS attack earlier than 48 hours is possible if a dorsal medulla lesion is detected. Accurate diagnosis and evaluation of APS attack severity will assist in outcome measurement in NMOSD clinical trials.
CSF cytokine profile in MOG-IgG+ neurological disease is similar to AQP4-IgG+ NMOSD but distinct from MS: A cross-sectional study and potential therapeutic implications Peer-reviewed

Kimihiko Kaneko, Douglas Kazutoshi Sato, Ichiro Nakashima, Ryo Ogawa, Tetsuya Akaishi, Yoshiki Takai, Shuhei Nishiyama, Toshiyuki Takahashi, Tatsuro Misu, Hiroshi Kuroda, Satoru Tanaka, Kyoichi Nomura, Yuji Hashimoto, Dagoberto Callegaro, Lawrence Steinman, Kazuo Fujihara, Masashi Aoki

Journal of Neurology, Neurosurgery and Psychiatry　89　(9)　927-936　2018/06/05
Publisher: BMJ Publishing Group
DOI： 10.1136/jnnp-2018-317969 　

ISSN： 1468-330X 0022-3050
Fingolimod-associated PML with mild IRIS in MS: A clinicopathologic study. International-journal Peer-reviewed

Shuhei Nishiyama, Tatsuro Misu, Yukiko Shishido-Hara, Kazuo Nakamichi, Masayuki Saijo, Yoshiki Takai, Kentarou Takei, Naoki Yamamoto, Hiroshi Kuroda, Ryuta Saito, Mika Watanabe, Teiji Tominaga, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki

Neurology(R) neuroimmunology & neuroinflammation　5　(1)　e415　2018/01

DOI： 10.1212/NXI.0000000000000415 　

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Objective: To clarify the clinical, neuropathologic, and virologic characteristics of progressive multifocal leukoencephalopathy (PML) and its immune reconstitution inflammatory syndrome (IRIS) in a patient with fingolimod-treated MS. Methods: A case study. Results: A 34-year-old patient with MS using fingolimod for 4 years had a gradual progression of right hemiparesis and aphasia with a new subcortical white matter lesion in the precentral gyrus by initial MRI. Blood tests were normal, except for lymphopenia (160 cells/μL). One month after the cessation of fingolimod, brain MRI depicted a diffusely exacerbated hyperintensity on fluid-attenuated inversion recovery and diffusion-weighed imaging in the white matter with punctate gadolinium enhancement, suggesting PML-IRIS. A very low level of JC virus (JCV)-DNA (15 copies/mL) was detected in the CSF as judged by quantitative PCR. Brain tissues were biopsied from the left frontal lesion, which showed some small demyelinated foci with predominant loss of myelin-associated glycoprotein with infiltrations of lymphocytes and macrophages, but clear viral inclusion was not observed with hematoxylin-eosin staining. JCV-DNA was uniquely detectable in an active inflammatory demyelinating lesion by in situ hybridization, possibly suggesting an early phase of PML. DNA extracted from the brain sample was positive for JCV-DNA (151 copies/cell). It took 3 months to normalize the blood lymphocyte count. The patient was treated with 1 g of IV methylprednisolone for 3 days and a weekly oral dose (375 mg) of mefloquine, and her symptoms gradually improved. Conclusion: Low CSF JCV-DNA and unfound viral inclusions initially made her diagnosis difficult. The clinical course of fingolimod-associated PML may be associated with mild immune reconstitution.
Bilateral frontal cortex encephalitis and paraparesis in a patient with anti-MOG antibodies Peer-reviewed

Fujimori, Juichi, Takai, Yoshiki, Nakashima, Ichiro, Sato, Douglas Kazutoshi, Takahashi, Toshiyuki, Kaneko, Kimihiko, Nishiyama, Shuhei, Watanabe, Mika, Tanji, Hiroaki, Kobayashi, Michiko, Misu, Tatsuro, Aoki, Masashi, Fujihara, Kazuo

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY　88　(6)　534-536　2017/06

DOI： 10.1136/jnnp-2016-315094 　

ISSN： 0022-3050

eISSN： 1468-330X
MOG antibody-positive, benign, unilateral, cerebral cortical encephalitis with epilepsy Peer-reviewed

Ryo Ogawa, Ichiro Nakashima, Toshiyuki Takahashi, Kimihiko Kaneko, Tetsuya Akaishi, Yoshiki Takai, Douglas Kazutoshi Sato, Shuhei Nishiyama, Tatsuro Misu, Hiroshi Kuroda, Masashi Aoki, Kazuo Fujihara

Neurology: Neuroimmunology and NeuroInflammation　4　(2)　e322　2017
Publisher: Lippincott Williams and Wilkins
DOI： 10.1212/NXI.0000000000000322 　

ISSN： 2332-7812

eISSN： 2332-7812
Myelin injury without astrocytopathy in neuroinflammatory disorders with MOG antibodies Peer-reviewed

Kimihiko Kaneko, Douglas Kazutoshi Sato, Ichiro Nakashima, Shuhei Nishiyama, Satoru Tanaka, Romain Marignier, Jae-Won Hyun, Luana Michelli de Oliveira, Markus Reindl, Thomas Seifert-Held, Maria Sepulveda, Sasitorn Siritho, Patrick Joseph Waters, Kazuhiro Kurosawa, Tetsuya Akaishi, Hiroshi Kuroda, Tatsuro Misu, Naraporn Prayoonwiwat, Thomas Berger, Albert Saiz, Ho Jin Kim, Kyoichi Nomura, Dagoberto Callegaro, Kazuo Fujihara, Masashi Aoki

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY　87　(11)　1257-U128　2016/11

DOI： 10.1136/jnnp-2015-312676 　

ISSN： 0022-3050

eISSN： 1468-330X
Hypoxia-like tissue injury and glial response contribute to Balo concentric lesion development Peer-reviewed

Yoshiki Takai, Tatsuro Misu, Shuhei Nishiyama, Hirohiko Ono, Hiroshi Kuroda, Ichiro Nakashima, Ryuta Saito, Masayuki Kanamori, Yukihiko Sonoda, Toshihiro Kumabe, Shunji Mugikura, Mika Watanabe, Masashi Aoki, Kazuo Fujihara

NEUROLOGY　87　(19)　2000-2005　2016/11

DOI： 10.1212/WNL.0000000000003308 　

ISSN： 0028-3878

eISSN： 1526-632X
Complement-dependent and -independent aquaporin 4-antibody-mediated cytotoxicity in human astrocytes: Pathogenetic implications in neuromyelitis optica. Peer-reviewed

Nishiyama S, Misu T, Nuriya M, Takano R, Takahashi T, Nakashima I, Yasui M, Itoyama Y, Aoki M, Fujihara K

Biochem. Biophys. Rep.　7　45-51　2016
Pregnancy outcomes in aquaporin-4-positive neuromyelitis optica spectrum disorder Peer-reviewed

Matthew M. Nour, Ichiro Nakashima, Ester Coutinho, Mark Woodhall, Filipa Sousa, Jon Revis, Yoshiki Takai, Jithin George, Joanna Kitley, Maria Ernestina Santos, Joseph M. Nour, Fan Cheng, Hiroshi Kuroda, Tatsuro Misu, Ana Martins-da-Silva, Gabriele C. DeLuca, Angela Vincent, Jacqueline Palace, Patrick Waters, Kazuo Fujihara, Maria Isabel Leite

NEUROLOGY　86　(1)　79-87　2016/01

DOI： 10.1212/WNL.0000000000002208 　

ISSN： 0028-3878

eISSN： 1526-632X
Highly encephalitogenic aquaporin 4-specific T cells and NMO-IgG jointly orchestrate lesion location and tissue damage in the CNS Peer-reviewed

Bleranda Zeka, Maria Hastermann, Sonja Hochmeister, Nikolaus Koegl, Nathalie Kaufmann, Kathrin Schanda, Simone Mader, Tatsuro Misu, Paulus Rommer, Kazuo Fujihara, Zsolt Illes, Fritz Leutmezer, Douglas Kazutoshi Sato, Ichiro Nakashima, Markus Reindl, Hans Lassmann, Monika Bradl

ACTA NEUROPATHOLOGICA　130　(6)　783-798　2015/12

DOI： 10.1007/s00401-015-1501-5 　

ISSN： 0001-6322

eISSN： 1432-0533
Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody Peer-reviewed

Kazuhiro Kurosawa, Tatsuro Misu, Yoshiki Takai, Douglas Kazutoshi Sato, Toshiyuki Takahashi, Yoichiro Abe, Hiroko Iwanari, Ryo Ogawa, Ichiro Nakashima, Kazuo Fujihara, Takao Hamakubo, Masato Yasui, Masashi Aoki

ACTA NEUROPATHOLOGICA COMMUNICATIONS　3　82　2015/12

DOI： 10.1186/s40478-015-0259-2 　

ISSN： 2051-5960
Clinical features and long-term outcome of a group of Japanese children with inflammatory central nervous system disorders and seropositivity to myelin-oligodendrocyte glycoprotein antibodies Peer-reviewed

Naomi Hino-Fukuyo, Kazuhiro Haginoya, Ichiro Nakashima, Douglas Kazutoshi Sato, Toshiyuki Takahashi, Tatsuro Misu, Kazuo Fujihara, Mieko Hirose, Yosuke Kakisaka, Mitsugu Uematsu, Tomoko Kobayashi, Shigeo Kure

BRAIN & DEVELOPMENT　37　(9)　849-852　2015/10

DOI： 10.1016/j.braindev.2015.02.006 　

ISSN： 0387-7604

eISSN： 1872-7131
MOG-IgG serological status matters in paediatric ADEM Peer-reviewed

Tatsuro Misu, Douglas Kazutoshi Sato, Ichiro Nakashima, Kazuo Fujihara

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY　86　(3)　242-242　2015/03

DOI： 10.1136/jnnp-2014-308723 　

ISSN： 0022-3050

eISSN： 1468-330X
The intrinsic pathogenic role of autoantibodies to aquaporin 4 mediating spinal cord disease in a rat passive-transfer model Peer-reviewed

Christian Geis, Christian Ritter, Christoph Ruschil, Andreas Weishaupt, Benedikt Gruenewald, Guido Stoll, Trygve Holmoy, Tatsuro Misu, Kazuo Fujihara, Bernhard Hemmer, Christine Stadelmann, Jeffrey L. Bennett, Claudia Sommer, Klaus V. Toyka

EXPERIMENTAL NEUROLOGY　265　8-21　2015/03

DOI： 10.1016/j.expneurol.2014.12.015 　

ISSN： 0014-4886

eISSN： 1090-2430
A case of pathology-proven neuromyelitis optica spectrum disorder with Sjogren syndrome manifesting aphasia and apraxia due to a localized cerebral white matter lesion Peer-reviewed

Jun Sawada, Ryosuke Orimoto, Tatsuro Misu, Takayuki Katayama, Hitoshi Aizawa, Asuka Asanome, Kae Takahashi, Tsukasa Saito, Ryogo Anei, Kyousuke Kamada, Naoyuki Miyokawa, Toshiyuki Takahashi, Kazuo Fujihara, Naoyuki Hasebe

MULTIPLE SCLEROSIS JOURNAL　20　(10)　1413-1416　2014/09

DOI： 10.1177/1352458514540834 　

ISSN： 1352-4585

eISSN： 1477-0970
Anti-N-Methyl-D-Aspartate Receptor Encephalitis with Multiphasic Demyelination Peer-reviewed

Kimihiko Kaneko, Douglas Kazutoshi Sato, Tatsuro Misu, Kazuhiro Kurosawa, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki

ANNALS OF NEUROLOGY　76　(3)　462-464　2014/09

DOI： 10.1002/ana.24224 　

ISSN： 0364-5134

eISSN： 1531-8249
Pain in neuromyelitis optica-prevalence, pathogenesis and therapy Peer-reviewed

Monika Bradl, Yoko Kanamori, Ichiro Nakashima, Tatsuro Misu, Kazuo Fujihara, Hans Lassmann, Juergen Sandkuehler

NATURE REVIEWS NEUROLOGY　10　(9)　529-536　2014/09

DOI： 10.1038/nrneurol.2014.129 　

ISSN： 1759-4758

eISSN： 1759-4766
Cerebrospinal Fluid Aquaporin-4 Antibody Levels in Neuromyelitis Optica Attacks Peer-reviewed

Douglas Kazutoshi Sato, Dagoberto Callegaro, Frederico M. de Haidar Jorge, Ichiro Nakashima, Shuhei Nishiyama, Toshiyuki Takahashi, Renata Faria Simm, Samira Luisa Apostolos-Pereira, Tatsuro Misu, Lawrence Steinman, Masashi Aoki, Kazuo Fujihara

ANNALS OF NEUROLOGY　76　(2)　305-309　2014/08

DOI： 10.1002/ana.24208 　

ISSN： 0364-5134

eISSN： 1531-8249
The Pathology of an Autoimmune Astrocytopathy: Lessons Learned from Neuromyelitis Optica Peer-reviewed

Claudia F. Lucchinetti, Yong Guo, Bogdan F. Gh. Popescu, Kazuo Fujihara, Yasuto Itoyama, Tatsuro Misu

BRAIN PATHOLOGY　24　(1)　83-97　2014/01

DOI： 10.1111/bpa.12099 　

ISSN： 1015-6305

eISSN： 1750-3639
Presence of six different lesion types suggests diverse mechanisms of tissue injury in neuromyelitis optica Peer-reviewed

Tatsuro Misu, Romana Hoeftberger, Kazuo Fujihara, Isabella Wimmer, Yoshiki Takai, Shuhei Nishiyama, Ichiro Nakashima, Hidehiko Konno, Monika Bradl, Ferenc Garzuly, Yasuto Itoyama, Masashi Aoki, Hans Lassmann

ACTA NEUROPATHOLOGICA　125　(6)　815-827　2013/06

DOI： 10.1007/s00401-013-1116-7 　

ISSN： 0001-6322

eISSN： 1432-0533
Aquaporin-4 antibody-positive cases beyond current diagnostic criteria for NMO spectrum disorders Peer-reviewed

Douglas Kazutoshi Sato, Ichiro Nakashima, Toshiyuki Takahashi, Tatsuro Misu, Patrick Waters, Hiroshi Kuroda, Shuhei Nishiyama, Chihiro Suzuki, Yoshiki Takai, Kazuo Fujihara, Yasuto Itoyama, Masashi Aoki

NEUROLOGY　80　(24)　2210-2216　2013/06

DOI： 10.1212/WNL.0b013e318296ea08 　

ISSN： 0028-3878

eISSN： 1526-632X
TWO CASES OF LUMBOSACRAL MYELORADICULITIS WITH ANTI-AQUAPORIN-4 ANTIBODY Peer-reviewed

Yoshiki Takai, Tatsuro Misu, Ichiro Nakashima, Toshiyuki Takahashi, Yasuto Itoyama, Kazuo Fujihara, Masashi Aoki

NEUROLOGY　79　(17)　1826-1828　2012/10

DOI： 10.1212/WNL.0b013e3182703ff7 　

ISSN： 0028-3878
Prognostic factors and disease course in aquaporin-4 antibody-positive patients with neuromyelitis optica spectrum disorder from the United Kingdom and Japan Peer-reviewed

Joanna Kitley, M. Isabel Leite, Ichiro Nakashima, Patrick Waters, Benjamin McNeillis, Rachel Brown, Yoshiki Takai, Toshiyuki Takahashi, Tatsuro Misu, Liene Elsone, Mark Woodhall, Jithin George, Mike Boggild, Angela Vincent, Anu Jacob, Kazuo Fujihara, Jacqueline Palace

BRAIN　135　(Pt 6)　1834-1849　2012/06

DOI： 10.1093/brain/aws109 　

ISSN： 0006-8950
Pain in neuromyelitis optica and its effect on quality of life A cross-sectional study Peer-reviewed

Y. Kanamori, I. Nakashima, Y. Takai, S. Nishiyama, H. Kuroda, T. Takahashi, C. Kanaoka-Suzuki, T. Misu, K. Fujihara, Y. Itoyama

NEUROLOGY　77　(7)　652-658　2011/08

DOI： 10.1212/WNL.0b013e318229e694 　

ISSN： 0028-3878
Pathogenic T cell responses against aquaporin 4 Peer-reviewed

Maria Pohl, Marie-Therese Fischer, Simone Mader, Kathrin Schanda, Maja Kitic, Rakhi Sharma, Isabella Wimmer, Tatsuro Misu, Kazuo Fujihara, Markus Reindl, Hans Lassmann, Monika Bradl

ACTA NEUROPATHOLOGICA　122　(1)　21-34　2011/07

DOI： 10.1007/s00401-011-0824-0 　

ISSN： 0001-6322
Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica Peer-reviewed

Masahiko Nakamura, Toru Nakazawa, Hiroshi Doi, Takehiro Hariya, Kazuko Omodaka, Tatsuro Misu, Toshiyuki Takahashi, Kazuo Fujihara, Kohji Nishida

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　248　(12)　1777-1785　2010/12

DOI： 10.1007/s00417-010-1344-7 　

ISSN： 0721-832X
Astrocytic damage is far more severe than demyelination in NMO A clinical CSF biomarker study Peer-reviewed

R. Takano, T. Misu, T. Takahashi, S. Sato, K. Fujihara, Y. Itoyama

NEUROLOGY　75　(3)　208-216　2010/07

DOI： 10.1212/WNL.0b013e3181e2414b 　

ISSN： 0028-3878
Neuromyelitis Optica: Pathogenicity of Patient Immunoglobulin In Vivo Peer-reviewed

Monika Bradl, Tatsuro Misu, Toshiyuki Takahashi, Mitsutoshi Watanabe, Simone Mader, Markus Reindl, Milena Adzemovic, Jan Bauer, Thomas Berger, Kazuo Fujhara, Yasuto Itoyama, Hans Lassmann

ANNALS OF NEUROLOGY　66　(5)　630-643　2009/11

DOI： 10.1002/ana.21837 　

ISSN： 0364-5134
A CASE OF NMO SEROPOSITIVE FOR AQUAPORIN-4 ANTIBODY MORE THAN 10 YEARS BEFORE ONSET Peer-reviewed

S. Nishiyama, T. Ito, T. Misu, T. Takahashi, A. Kikuchi, N. Suzuki, K. Jin, M. Aoki, K. Fujihara, Y. Itoyama

NEUROLOGY　72　(22)　1960-1961　2009/06

DOI： 10.1212/WNL.0b013e3181a82621 　

ISSN： 0028-3878
Marked increase in cerebrospinal fluid glial fibrillar acidic protein in neuromyelitis optica: an astrocytic damage marker Peer-reviewed

T. Misu, R. Takano, K. Fujihara, T. Takahashi, S. Sato, Y. Itoyama

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY　80　(5)　575-577　2009/05

DOI： 10.1136/jnnp.2008.150698 　

ISSN： 0022-3050
Low-dose corticosteroids reduce relapses in neuromyelitis optica: a retrospective analysis Peer-reviewed

S. Watanabe, T. Misu, I. Miyozawa, I. Nakashima, Y. Shiga, K. Fujihara, Y. Itoyama

MULTIPLE SCLEROSIS　13　(8)　968-974　2007/09

DOI： 10.1177/1352458507077189 　

ISSN： 1352-4585
Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre Peer-reviewed

Takahashi, Toshiyuki, Fujihara, Kazuo, Nakashima, Ichiro, Misu, Tatsuro, Miyazawa, Isabelle, Nakamura, Masashi, Watanabe, Shohei, Shiga, Yusei, Kanaoka, Chihiro, Fujimori, Juichi, Sato, Shigeru, Itoyama, Yasuto

BRAIN　130　(Pt 5)　1235-1243　2007/05

DOI： 10.1093/brain/awm062 　

ISSN： 0006-8950
Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis Peer-reviewed

T. Misu, K. Fujihara, A. Kakita, H. Konno, M. Nakamura, S. Watanabe, T. Takahashi, I. Nakashima, H. Takahashi, Y. Itoyama

BRAIN　130　(Pt 5)　1224-1234　2007/05

DOI： 10.1093/brain/awm047 　

ISSN： 0006-8950
Establisbment of a new sensitive assay for anti-human aquaporin-4 antibody in neuromyelitis optica Peer-reviewed

Toshiyuki Takahashi, Kazuo Fujihara, Ichiro Nakashima, Tatsuro Misu, Isabelle Miyazawa, Masashi Nakamura, Shohei Watanabe, Naoto Ishii, Yasuto Itoyama

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　210　(4)　307-313　2006/12

DOI： 10.1620/tjem.210.307 　

ISSN： 0040-8727

eISSN： 1349-3329
Loss of aquaporin-4 in active perivascular lesions in neuromyelitis optica: A case report Peer-reviewed

Tatsuro Misu, Kazuo Fujihara, Masashi Nakamura, Kazuhiro Murakami, Minoru Endo, Hidehiko Konno, Yasuto Itoyama

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　209　(3)　269-275　2006/07

DOI： 10.1620/tjem.209.269 　

ISSN： 0040-8727

eISSN： 1349-3329
Intractable hiccup and nausea with periaqueductal lesions in neuromyelitis optica Peer-reviewed

T Misu, K Fujihara, Nakashima, I, S Sato, Y Itoyama

NEUROLOGY　65　(9)　1479-1482　2005/11

DOI： 10.1212/01.wnl.0000183151.19351.82 　

ISSN： 0028-3878
Ibudilast, a nonselective phosphodiesterase inhibitor, regulates Th1/Th2 balance and NKT cell subset in multiple sclerosis Peer-reviewed

J Feng, T Misu, K Fujihara, S Sakoda, Y Nakatsuji, H Fukaura, S Kikuchi, K Tashiro, A Suzumura, N Ishii, K Sugamura, Nakashima, I, Y Itoyama

MULTIPLE SCLEROSIS　10　(5)　494-498　2004

DOI： 10.1191/1352458504ms1070oa 　

ISSN： 1352-4585
Complementarity-determining region 3 spectratyping analysis of the TCR repertoire in multiple sclerosis Peer-reviewed

Y Matsumoto, WK Yoon, Y Jee, K Fujihara, T Misu, S Sato, Nakashima, I, Y Itoyama

JOURNAL OF IMMUNOLOGY　170　(9)　4846-4853　2003/05

ISSN： 0022-1767
Pure optic-spinal form of multiple sclerosis in Japan Peer-reviewed

T Misu, K Fujihara, Nakashima, I, Miyazawa, I, N Okita, S Takase, Y Itoyama

BRAIN　125　(Pt 11)　2460-2468　2002/11

ISSN： 0006-8950
Chemokine receptor expression on T cells in blood and cerebrospinal fluid at relapse and remission of multiple sclerosis: imbalance of Th1/Th2-associated chemokine signaling Peer-reviewed

T Misu, H Onodera, K Fujihara, K Matsushima, O Yoshie, N Okita, S Takase, Y Itoyama

JOURNAL OF NEUROIMMUNOLOGY　114　(1-2)　207-212　2001/03

DOI： 10.1016/S0165-5728(00)00456-2 　

ISSN： 0165-5728
Effectiveness of Satralizumab in a Real-world Clinical Setting in Japan: Interleukin-6 Receptor Inhibition in Neuromyelitis Optica Spectrum Disorder: A Six-month Interim Analysis of a Multicenter Medical Chart Review

Kazuo Fujihara, Noriko Isobe, Katsuichi Miyamoto, Masaaki Niino, Jin Nakahara, Satoshi Hattori, Mamoru Yamamoto, Izumi Kawachi, Naoko Matsui, Chiyoko Nohara, Norito Kokubun, Norio Chihara, Tatsuro Misu, Kazumasa Okada, Katsuhisa Yamashita, Tadashi Nagatsuka, Hiroki Adachi, Ichiro Nakashima

Multiple Sclerosis and Related Disorders　106384-106384　2025/03
Publisher: Elsevier BV
DOI： 10.1016/j.msard.2025.106384 　

ISSN： 2211-0348
Clinical practice guidelines for multiple sclerosis, neuromyelitis optica spectrum disorder, and myelin oligodendrocyte glycoprotein antibody-associated disease 2023 in Japan. International-journal Peer-reviewed

Masaaki Niino, Noriko Isobe, Manabu Araki, Takashi Ohashi, Tomoko Okamoto, Mieko Ogino, Tatsusada Okuno, Hirofumi Ochi, Izumi Kawachi, Yuko Shimizu, Kazuya Takahashi, Hideyuki Takeuchi, Masayuki Tahara, Norio Chihara, Ichiro Nakashima, Hikoaki Fukaura, Tatsuro Misu, Yusei Miyazaki, Katsuichi Miyamoto, Masahiro Mori, Makoto Kinoshita, Yoshiki Takai, Chihiro Fujii, Mitsuru Watanabe, Kazuo Fujihara

Multiple sclerosis and related disorders　90　105829-105829　2024/08/17

DOI： 10.1016/j.msard.2024.105829 　

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BACKGROUND: The previous Japanese clinical practice guidelines for multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) were published in 2017. Recently, for the first time in 6 years, the MS and NMOSD guideline development committee revised the Japanese guidelines for MS, NMOSD, and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). METHODS: The committee utilized the Grading of Recommendations Assessment, Development, and Evaluation system based on the "Minds Handbook for Clinical Practice Guideline Development 2020 Ver. 3.0″ with a focus on clinical questions (CQs). The committee also discussed clinical issues other than CQs, categorizing them as a question-and-answer (Q&A) section, including "issues on which experts' opinions agree to a certain extent" and "issues that are important but not included in the CQ". RESULTS: The committee identified 3, 1, and 1 key CQs related to MS, NMOSD, and MOGAD, respectively, and presented recommendations. A Q&A session regarding disease-modifying therapies and relapse prevention therapies for MS, NMOSD, and MOGAD was conducted. The revised guidelines were published in September 2023. CONCLUSIONS: The Japanese guidelines for clinical practice on MS, NMOSD, and MOGAD were updated. Treatment strategies for MS, NMOSD, and MOGAD are changing, and these updated guidelines may assist with treatment decisions for these diseases in clinical practice.
Humanized-Aquaporin-4-Expressing Rat Created by Gene-Editing Technology and Its Use to Clarify the Pathology of Neuromyelitis Optica Spectrum Disorder. International-journal

Chihiro Namatame, Yoichiro Abe, Yoshiki Miyasaka, Yoshiki Takai, Yuki Matsumoto, Toshiyuki Takahashi, Tomoji Mashimo, Tatsuro Misu, Kazuo Fujihara, Masato Yasui, Masashi Aoki

International journal of molecular sciences　25　(15)　2024/07/26

DOI： 10.3390/ijms25158169 　

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Conventional rodent neuromyelitis optica spectrum disorder (NMOSD) models using patient-derived immunoglobulin G (IgG) are potentially affected by the differences between the human and rodent aquaporin-4 (AQP4) extracellular domains (ECDs). We hypothesized that the humanization of AQP4 ECDs would make the rodent model lesions closer to human NMOSD pathology. Humanized-AQP4-expressing (hAQP4) rats were generated using genome-editing technology, and the human AQP4-specific monoclonal antibody (mAb) or six patient-derived IgGs were introduced intraperitoneally into hAQP4 rats and wild-type Lewis (WT) rats after immunization with myelin basic protein and complete Freund's adjuvant. Human AQP4-specific mAb induced astrocyte loss lesions specifically in hAQP4 rats. The patient-derived IgGs also induced NMOSD-like tissue-destructive lesions with AQP4 loss, demyelination, axonal swelling, complement deposition, and marked neutrophil and macrophage/microglia infiltration in hAQP4 rats; however, the difference in AQP4 loss lesion size and infiltrating cells was not significant between hAQP4 and WT rats. The patient-derived IgGs bound to both human and rat AQP4 M23, suggesting their binding to the shared region of human and rat AQP4 ECDs. Anti-AQP4 titers positively correlated with AQP4 loss lesion size and neutrophil and macrophage/microglia infiltration. Considering that patient-derived IgGs vary in binding sites and affinities and some of them may not bind to rodent AQP4, our hAQP4 rat is expected to reproduce NMOSD-like pathology more accurately than WT rats.
Multicenter, randomized, double-blind, placebo-controlled phase 3 study of mogamulizumab with open-label extension study in a minimum number of patients with human T-cell leukemia virus type-1-associated myelopathy

Tomoo Sato, Masahiro Nagai, Osamu Watanabe, Tatsuro Misu, Norihiro Takenouchi, Ryuichi Ohkubo, Satoshi Ishihara, Yoshio Tsuboi, Masahisa Katsuno, Masanori Nakagawa, Takuya Matsushita, Yasuhiro Aso, Eiji Matsuura, Takashi Tokashiki, Akihiro Mukaino, Hiroaki Adachi, Kaoru Nakanishi, Yusuke Yamaguchi, Saaya Yamaguchi, Yoshihisa Yamano

Journal of Neurology　271　(6)　3471-3485　2024/06

DOI： 10.1007/s00415-024-12239-x 　

ISSN： 0340-5354

eISSN： 1432-1459
Stochastic models for the onset and disease course of multiple sclerosis. International-journal

Tetsuya Akaishi, Tatsuro Misu, Toshiyuki Takahashi, Kazuo Fujihara, Juichi Fujimori, Ichiro Nakashima, Masashi Aoki

Clinical neurology and neurosurgery　239　108224-108224　2024/03/02

DOI： 10.1016/j.clineuro.2024.108224 　

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OBJECTIVE: Exact causes and mechanisms regulating the onset and progression in many chronic diseases, including multiple sclerosis (MS), remain uncertain. Until now, the potential role of random process based on stochastic models in the temporal course of chronic diseases remains largely unevaluated. Therefore, the present study investigated the applicability of stochastic models for the onset and disease course of MS. METHODS: Stochastic models with random temporal process in disease activity, underlying clinical relapse and/or subclinical brain atrophy, were developed. The models incorporated parameters regarding the distribution of temporal changes in disease activity and the drift constant. RESULTS: By adjusting the parameters (temporal change dispersion and drift constant) and the threshold for the onset of disease, the stochastic disease progression models could reproduce various types of subsequent disease course, such as clinically isolated syndrome (monophasic), relapsing-remitting MS, primary-progressive MS, and secondary-progressive MS. Furthermore, the disease prevalence and distribution of onset age could be also reproduced with stochastic models by adjusting the parameters. The models could further explain why approximately half of the patients with relapsing-remitting MS will eventually experience a transition to secondary-progressive MS. CONCLUSION: Stochastic models with random temporal changes in disease activity could reproduce the characteristic onset age distribution and disease course forms in MS. Further studies by using real-world data to underscore the significance of random process in the occurrence and progression of MS are warranted.
Laser speckle flowgraphyを用いた視神経炎病態別の眼内血流評価について

山口知暁, 檜森紀子, 清田直樹, 大島隆寛, 木村暸, 津田聡, 面高宗子, 三須建郎, 青木正志, 中澤徹

日本眼科学会雑誌　128　(臨増)　193-193　2024/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Laser speckle flowgraphyを用いた視神経炎病態別の眼内血流評価について

山口知暁, 檜森紀子, 清田直樹, 大島隆寛, 木村暸, 津田聡, 面高宗子, 三須建郎, 青木正志, 中澤徹

日本眼科学会雑誌　128　(臨増)　193-193　2024/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Case Report: An Adult Case of Poretti-Boltshauser Syndrome Diagnosed by Medical Checkup. International-journal

Kensuke Ikeda, Ayane Tamagake, Takafumi Kubota, Rumiko Izumi, Tatsuo Yamaguchi, Kumiko Yanagi, Tatsuro Misu, Yoko Aoki, Tadashi Kaname, Masashi Aoki

Cerebellum (London, England)　2024/02/29

DOI： 10.1007/s12311-024-01673-2 　

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This report describes an adult case of Poretti-Boltshauser syndrome (PTBHS) and with novel variants of LAMA1. A 65-year-old Japanese woman with cerebellar malformation identified during a medical checkup was referred to our hospital. Subsequently, neurological examination, brain imaging, and genetic investigation via whole-exome sequencing were performed. The patient presented with mild cerebellar ataxia and intellectual disability. Magnetic resonance imaging revealed cerebellar dysplasia and cysts and an absence of molar tooth sign. Genetic analysis revealed a novel homozygous variant of c.1711_1712del in LAMA1 (NM_005559.4). Most cases with PTBHS are reported in pediatric patients; however, our patient expressed a mild phenotype and was undiagnosed until her 60 s. These findings suggest that PTBHS should be considered in not only pediatric cerebellar dysplasia but also adult cerebellar ataxia with mild presentation.
CNS B cell infiltration in tumefactive anti-myelin oligodendrocyte glycoprotein antibody-associated disease. International-journal

Ryotaro Ikeguchi, Natsuki Kanda, Masaki Kobayashi, Kenta Masui, Masayuki Nitta, Tatsuro Misu, Yoshihiro Muragaki, Takakazu Kawamata, Noriyuki Shibata, Kazuo Kitagawa, Yuko Shimizu

Multiple sclerosis journal - experimental, translational and clinical　10　(4)　20552173241301011-20552173241301011　2024

DOI： 10.1177/20552173241301011 　

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BACKGROUND: Few studies have examined B cells among patients with anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD), including brain pathology. OBJECTIVE: To describe cases of tumefactive MOGAD with B-cell dominant central nervous system (CNS) infiltration. METHODS: In this study, we reviewed three cases with clinical and brain histopathological features with tumefactive MOGAD. RESULTS: Forty-nine cases of tumefactive brain lesions (TBL) between January 2003 and December 2023 were included; of these, seven had MOGAD. Three underwent a brain biopsy. B-cell dominant CNS infiltration was observed in two cases. In two cases with B-cell dominant CNS infiltration, symptoms included fever, headache, nausea, somnolence, and focal neurological deficits. Cerebrospinal fluid examination revealed both mild pleocytosis and negative oligoclonal IgG bands. Magnetic resonance imaging of the brain revealed large abnormal lesions extending from the basal ganglia to the parietotemporal lobe in both cases. These cases showed a good response to steroids; however, one case relapsed. Brain pathology showed demyelination and perivascular lymphocytic infiltration. One showed small vessel vasculitis. Deposition of the activated complement component was absent or rarely observed. Loss of MOG was observed in two cases. CONCLUSION: MOGAD could exhibit B-cell dominant CNS infiltration and small vessel vasculitis. MOGAD should be considered in differential diagnosis of TBL.
Dynamic changes in patient admission and their disabilities in multiple sclerosis and neuromyelitis optica: A Japanese nationwide administrative data study

Yuki Matsumoto, Kunio Tarasawa, Tatsuro Misu, Chihiro Namatame, Yoshiki Takai, Hiroshi Kuroda, Kazuo Fujihara, Kiyohide Fushimi, Kenji Fujimori, Masashi Aoki

Multiple Sclerosis and Related Disorders　81　105349-105349　2024/01
Publisher: Elsevier BV
DOI： 10.1016/j.msard.2023.105349 　

ISSN： 2211-0348
抗NMDAR抗体と抗GFAPα抗体が陽性であった抗MOG抗体関連脳炎の35歳女性例

若生翔, 池口亮太郎, 山岸沙衣, 金子仁彦, 三須建郎, 北川一夫, 清水優子

神経免疫学　28　(1)　253-253　2023/09
Publisher: (一社)日本神経免疫学会
ISSN： 0918-936X
MOGAD急性期髄液における活性化補体の解析

金子仁彦, 黒田宙, 小野紘彦, 松本勇貴, 阪本直広, 山崎直也, 山本尚輝, 梅澤周, 生田目知尋, 高井良樹, 高橋利幸, 藤盛寿一, 中島一郎, 藤原一男, 三須建郎, 青木正志

神経免疫学　28　(1)　200-200　2023/09
Publisher: (一社)日本神経免疫学会
ISSN： 0918-936X
Distal Chronic Inflammatory Demyelinating Polyneuropathy Following COVID-19 Vaccination in a Patient with Solitary Plasmacytoma: A Case Report and Literature Review

Takafumi Kubota, Tomomi Shijo, Kensho Ikeda, Yoshihiko Mitobe, Shu Umezawa, Tatsuro Misu, Takafumi Hasegawa, Masashi Aoki

Internal Medicine　62　(16)　2419-2425　2023/08/15
Publisher: Japanese Society of Internal Medicine
DOI： 10.2169/internalmedicine.1365-22 　

ISSN： 0918-2918

eISSN： 1349-7235
Associations between neuromyelitis optica spectrum disorder, Sjögren's syndrome, and conditions with electrolyte disturbances. International-journal

Tetsuya Akaishi, Kunio Tarasawa, Yuki Matsumoto, Pulukool Sandhya, Tatsuro Misu, Kiyohide Fushimi, Toshiyuki Takahashi, Juichi Fujimori, Tadashi Ishii, Kenji Fujimori, Nobuo Yaegashi, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki

Journal of the neurological sciences　452　120742-120742　2023/07/24

DOI： 10.1016/j.jns.2023.120742 　

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OBJECTIVE: Electrolyte disorders are among the important conditions negatively affecting the disease course of neuromyelitis optica spectrum disorder (NMOSD). Possible mechanisms may include renal tubular acidosis (RTA) accompanying Sjögren's syndrome (SS), syndrome of inappropriate antidiuretic hormone secretion (SIADH), and central diabetes insipidus (DI). Currently, the overlap profiles between these conditions remain uncertain. METHODS: This cross-sectional study collected data from the nationwide administrative Diagnosis Procedure Combination (DPC) database and evaluated the overlap profiles. RESULTS: Among the 28,285,908 individuals from 1203 DPC-covered hospitals, 8477 had NMOSD, 174108 had SS, 4977 had RTA, 7640 had SIADH, and 24,789 had central DI. Of those with NMOSD, 986 (12%) had SS. The odds ratio (OR) for a diagnosis of NMOSD in those with SS compared with those without was 21 [95% confidence interval (CI), 20-23]. Overlap between NMOSD and SS was seen both in males (OR, 28 [95% CI, 23-33]) and females (OR, 16 [15-17]) and was more prominent in the younger population. Among patients with SS, the prevalence of RTA was lower in patients with NMOSD compared with those without NMOSD. Patients with NMOSD showed a higher prevalence of SIADH (OR, 11 [7.5-17]; p < 0.0001) and DI (OR, 3.7 [2.4-5.3]; p < 0.0001). Comorbid SS in NMOSD was associated with a higher prevalence of DI. CONCLUSIONS: Patients with NMOSD are likely to have SS, SIADH, and central DI. RTA in SS does not facilitate the overlap between NMOSD and SS. SS in NMOSD may predispose patients to DI.
Reply to the Letter "Reversible Vasoconstriction Syndrome is a Complication of SARS-CoV-2 Infection/Vaccination Rather Than That of Leigh Syndrome".

Ayane Ohyama-Tamagake, Kimihiko Kaneko, Ryo Itami, Masatsugu Nakano, Yasuhiro Namioka, Rumiko Izumi, Haruka Sato, Hideaki Suzuki, Atsuhito Takeda, Yukiko Yatsuka, Yasushi Okazaki, Takaaki Abe, Kei Murayama, Naoto Sugeno, Tatsuro Misu, Masashi Aoki

Internal medicine (Tokyo, Japan)　2023/04/21

DOI： 10.2169/internalmedicine.1962-23 　
Time-Dependent Analysis of Sicca Symptoms and Anti-Ro/SSA and Anti-La/SSB Antibodies in Patients with AQP4-IgG-Positive Neuromyelitis Optica Spectrum Disorder.

Tetsuya Akaishi, Toshiyuki Takahashi, Tatsuro Misu, Kazuo Fujihara, Ichiro Nakashima, Masashi Aoki

The Tohoku journal of experimental medicine　2023/04/20

DOI： 10.1620/tjem.2023.J034 　
White blood cell count profiles in anti-aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorder and anti-myelin oligodendrocyte glycoprotein antibody-associated disease. International-journal

Tetsuya Akaishi, Tatsuro Misu, Kazuo Fujihara, Kumi Nakaya, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Kimihiko Kaneko, Toshiyuki Takahashi, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima, Atsushi Hozawa

Scientific reports　13　(1)　6481-6481　2023/04/20

DOI： 10.1038/s41598-023-33827-3 　

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White blood cell (WBC) count profiles in anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD) and anti-myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are still unknown. This study evaluated the total WBC count, differential WBC counts, monocyte-to-lymphocyte ratio (MLR), and neutrophil-to-lymphocyte ratio (NLR) in patients with these diseases within three months from an attack before acute treatment or relapse prevention and compared the profiles with those in matched volunteers or in multiple sclerosis (MS) patients. AQP4-NMOSD patients (n = 13) had a higher neutrophil count (p = 0.0247), monocyte count (p = 0.0359), MLR (p = 0.0004), and NLR (p = 0.0037) and lower eosinophil (p = 0.0111) and basophil (p = 0.0283) counts than those of AQP4-NMOSD-matched volunteers (n = 65). Moreover, patients with MOGAD (n = 26) had a higher overall WBC count (p = 0.0001), neutrophil count (p < 0.0001), monocyte count (p = 0.0191), MLR (p = 0.0320), and NLR (p = 0.0002) than those of MOGAD-matched volunteers (n = 130). The three demyelinating diseases showed similar levels of the total and differential WBC counts; however, MOGAD and MS showed different structures in the hierarchical clustering and distributions on a two-dimensional canonical plot using differential WBC counts from the other three groups. WBC count profiles were similar in patients with MOGAD and MS but differed from profiles in matched volunteers or patients with AQP4-NMOSD.
免疫療法が奏功した本邦2家系目の遺伝性神経痛性筋萎縮症の1例

梅澤岳助, 金子仁彦, 石川周, 井泉瑠美子, 三須建郎, 長谷川隆文, 青木正志

臨床神経学　63　(4)　245-245　2023/04
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
Paths to hippocampal damage in neuromyelitis optica spectrum disorders Peer-reviewed

Mona Zakani, Magdalini Nigritinou, Markus Ponleitner, Yoshiki Takai, Daniel Hofmann, Sophie Hillebrand, Romana Höftberger, Jan Bauer, Balint Lasztoczi, Tatsuro Misu, Gregor Kasprian, Paulus Rommer, Monika Bradl

Neuropathology and Applied Neurobiology　49　(2)　e12893　2023/03/06
Publisher: Wiley
DOI： 10.1111/nan.12893 　

ISSN： 0305-1846

eISSN： 1365-2990
Pathology of myelin oligodendrocyte glycoprotein antibody-associated disease: a comparison with multiple sclerosis and aquaporin 4 antibody-positive neuromyelitis optica spectrum disorders. International-journal

Yoshiki Takai, Tatsuro Misu, Kazuo Fujihara, Masashi Aoki

Frontiers in neurology　14　1209749-1209749　2023

DOI： 10.3389/fneur.2023.1209749 　

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Myelin oligodendrocyte glycoprotein (MOG) is expressed on the outermost layer of the myelin sheath in the central nervous system. Recently, the clinical concept of MOG antibody-associated disease (MOGAD) was established based on the results of human MOG-transfected cell-based assays which can detect conformation-sensitive antibodies against MOG. In this review, we summarized the pathological findings of MOGAD and discussed the issues that remain unresolved. MOGAD pathology is principally inflammatory demyelination without astrocyte destruction, characterized by perivenous demyelination previously reported in acute disseminated encephalomyelitis and by its fusion pattern localized in both the white and gray matter, but not by radially expanding confluent demyelination typically seen in multiple sclerosis (MS). Some of demyelinating lesions in MOGAD show severe loss of MOG staining compared with those of other myelin proteins, suggesting a MOG-targeted pathology in the disease. Perivascular cuffings mainly consist of macrophages and T cells with CD4-dominancy, which is also different from CD8+ T-cell-dominant inflammation in MS. Compared to aquaporin 4 (AQP4) antibody-positive neuromyelitis optica spectrum disorders (NMOSD), perivenous complement deposition is less common, but can be seen on myelinated fibers and on myelin degradation products within macrophages, resembling MS Pattern II pathology. Thus, the pathogenetic contribution of complements in MOGAD is still debatable. Together, these pathological features in MOGAD are clearly different from those of MS and AQP4 antibody-positive NMOSD, suggesting that MOGAD is an independent autoimmune demyelinating disease entity. Further research is needed to clarify the exact pathomechanisms of demyelination and how the pathophysiology relates to the clinical phenotype and symptoms leading to disability in MOGAD patients.
Complement-dependent cytotoxicity of human autoantibodies against myelin oligodendrocyte glycoprotein. International-journal

Kuniko Kohyama, Hiroya Nishida, Kimihiko Kaneko, Tatsuro Misu, Ichiro Nakashima, Hiroshi Sakuma

Frontiers in neuroscience　17　1014071-1014071　2023

DOI： 10.3389/fnins.2023.1014071 　

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BACKGROUND: The autoantibody to myelin oligodendrocyte glycoprotein (MOG), a component of the central nervous system myelin, has been identified in a subset of demyelinating diseases. However, there is no convincing evidence to support the direct pathogenic contribution of this autoantibody. OBJECTIVE: To elucidate the role of anti-MOG autoantibodies in human demyelinating disorders, we assessed the effect of autoantibodies on MOG-expressing cells. METHODS: Mammalian cells expressing the human MOG protein reacted with human anti-MOG autoantibodies in the presence or absence of complement. Sera from 86 patients and 11 healthy sera were used. We analyzed anti-MOG antibody titers, IgG subclass, and their cytotoxic ability in sera from patients with various neurological diseases. Membrane attack complex (MAC) formation was examined by detection of complement C9 or C9neo with western blot or flow cytometry. RESULTS: Among 86 patients, 40 were determined to be MOG-IgG-positive and 46 were negative. Anti-MOG-positive sera, but not -negative sera, caused cell death in MOG-expressing cells. This cytotoxic effect was disappeared after heat inactivation of sera. Importantly, anti-MOG IgG and externally added complement were necessary for sufficient cytotoxic effects. Anti-MOG autoantibodies were histologically colocalized with complement and formed a membrane attack complex consisting of anti-MOG IgG and complement factors. CONCLUSION: The human MOG antibody specifically killed MOG-expressing cells in vitro in the presence of externally added complement. Membrane attack complexes were formed on the cells, indicating that this autoantibody activated complement-mediated cytotoxicity. Further studies in larger numbers of patients are needed to characterize the role of complement in MOGAD.
Spinal Cord Infarction in an Adolescent with Protein S Deficiency: A Case Report and Literature Review

Takafumi Kubota, Tatsuhiko Hosaka, Daisuke Ando, Kensuke Ikeda, Rumiko Izumi, Tatsuro Misu, Hitoshi Warita, Masashi Aoki

Internal Medicine　2023
Publisher: Japanese Society of Internal Medicine
DOI： 10.2169/internalmedicine.0153-22 　

ISSN： 0918-2918

eISSN： 1349-7235
Adult-onset Leigh Syndrome with a m.9176 T>C Mutation Manifested as Reversible Cerebral Vasoconstriction Syndrome.

Ayane Ohyama-Tamagake, Kimihiko Kaneko, Ryo Itami, Masatsugu Nakano, Yasuhiro Namioka, Rumiko Izumi, Haruka Sato, Hideaki Suzuki, Atsuhito Takeda, Yasushi Okazaki, Yukiko Yatsuka, Takaaki Abe, Kei Murayama, Naoto Sugeno, Tatsuro Misu, Masashi Aoki

Internal medicine (Tokyo, Japan)　2022/12/21

DOI： 10.2169/internalmedicine.0773-22 　

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A 26-year-old woman developed a sudden headache, ptosis, and diplopia. Magnetic resonance imaging and angiography demonstrated a symmetrical lesion from the midbrain to the brainstem, involving the solitary nucleus and multifocal cerebral artery narrowing. Reversible cerebral vasospasm syndrome (RCVS) was suspected, and the patient improved after vasodilatation. Leigh syndrome was suspected due to the elevated serum lactate levels, so mitochondrial DNA was analyzed, and an m.9176 T>C mutation was detected. The final diagnosis was adult-onset Leigh syndrome manifesting as RCVS. An uncontrolled baroreflex due to a solitary nuclear lesion or endothelial dysfunction may have contributed to her unique presentation.
Parkinson病との鑑別を要した晩発性中脳水道狭窄症の一例.

山崎直也, 池田謙輔, 宮田杏子, 三須建郎, 長谷川隆文, 青木正志

臨床神経学　62　(11)　904-904　2022/11
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
Paraneoplastic Neuromyelitis Optica Spectrum Disorder Related to Glucose-regulated Protein 78 (GRP78) Autoantibodies in a Patient with Lynch Syndrome-associated Colorectal Cancer.

Shogo Minomo, Masahiko Ichijo, Fumitaka Shimizu, Ryota Sato, Takashi Kanda, Yoshiki Takai, Tatsuro Misu, Yoshiki Sakurai, Takeshi Amino, Tomoyuki Kamata

Internal medicine (Tokyo, Japan)　62　(11)　1653-1657　2022/10/26

DOI： 10.2169/internalmedicine.9783-22 　

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Neuromyelitis optica spectrum disorders have been previously reported in a paraneoplastic context, although there is no clear consensus on their pathogenesis. We herein report a case of aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder in a 64-year-old woman with colorectal cancer. She underwent tumor resection, resulting in serum aquaporin-4 antibody titers subsequently becoming negative. Serum samples were also positive for glucose-regulated protein 78 antibody, which has recently been suggested to be a novel factor in the disruption of the blood-brain barrier. Serological and pathological investigations in this case highlight the role and involvement of aquaporin-4 and glucose-regulated protein 78 antibodies in paraneoplastic conditions.
The Immediate Onset of Isolated and Unilateral Abducens Nerve Palsy Associated with COVID-19 Infection: A Case Report and Literature Review

Takafumi Kubota, Naoto Sugeno, Hirohito Sano, Koji Murakami, Kensuke Ikeda, Tatsuro Misu, Masashi Aoki

Internal Medicine　61　(11)　1761-1765　2022/06/01
Publisher: Japanese Society of Internal Medicine
DOI： 10.2169/internalmedicine.9308-22 　

ISSN： 0918-2918

eISSN： 1349-7235
Follow-up of retinal thickness and optic MRI after optic neuritis in anti-MOG antibody-associated disease and anti-AQP4 antibody-positive NMOSD

Tetsuya Akaishi, Noriko Himori, Takayuki Takeshita, Tatsuro Misu, Toshiyuki Takahashi, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Juichi Fujimori, Tadashi Ishii, Masashi Aoki, Kazuo Fujihara, Toru Nakazawa, Ichiro Nakashima

Journal of the Neurological Sciences　437　120269-120269　2022/06
Publisher: Elsevier BV
DOI： 10.1016/j.jns.2022.120269 　

ISSN： 0022-510X
COVID-19後に皮膚筋炎を発症した一例

岡田友里, 保坂龍彦, 渡部聡, 四條友望, 井泉瑠美子, 三須建郎, 青木正志, 八丁目直和, 小西里沙, 市村裕輝, 沖山奈緒子

臨床神経学　62　(5)　405-405　2022/05
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
Decreased subcortical T2 FLAIR signal with cortical T2 FLAIR hyperintense lesions in unilateral cerebral cortical encephalitis with myelin oligodendrocyte glycoprotein antibody Peer-reviewed

Juichi Fujimori, Ryo Ogawa, Takaki Murata, Yoshiki Takai, Tatsuro Misu, Ichiro Nakashima

Neuroimmunology Reports　100096-100096　2022/05
Publisher: Elsevier BV
DOI： 10.1016/j.nerep.2022.100096 　

ISSN： 2667-257X
Exploring steroid tapering in patients with neuromyelitis optica spectrum disorder treated with satralizumab in SAkuraSky: A case series Peer-reviewed

Takashi Yamamura, Manabu Araki, Kazuo Fujihara, Tatsusada Okuno, Tatsuro Misu, Yuh-Cherng Guo, Cheryl Hemingway, Junnosuke Matsushima, Naofumi Sugaya, Masami Yamashita, H.-Christian von Büdingen, Katsuichi Miyamoto

Multiple Sclerosis and Related Disorders　61　103772-103772　2022/05
Publisher: Elsevier BV
DOI： 10.1016/j.msard.2022.103772 　

ISSN： 2211-0348
MOG Antibody-Associated Disorders Following SARS-CoV-2 Vaccination: A Case Report and Literature Review

Yuki Matsumoto, Ayane Ohyama, Takafumi Kubota, Kensuke Ikeda, Kimihiko Kaneko, Yoshiki Takai, Hitoshi Warita, Toshiyuki Takahashi, Tatsuro Misu, Masashi Aoki

Frontiers in Neurology　13　2022/03/01
Publisher: Frontiers Media SA
DOI： 10.3389/fneur.2022.845755 　

eISSN： 1664-2295

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Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disorder (MOGAD) is a newly identified autoimmune demyelinating disorder that is often associated with acute disseminated encephalomyelitis and usually occurs postinfection or postvaccination. Here we report a case of MOGAD after mRNA severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. A previously healthy 68-year-old woman presented to our department with gradually worsening numbness on the right side of her face, which began 14 days after her second dose of an mRNA-1273 vaccination. The patient's brain MRI revealed a right cerebellar peduncle lesion with gadolinium enhancement, a typical finding of MOGAD. A neurological examination revealed paresthesia on her right V2 and V3 areas. Other neurological examinations were unremarkable. Laboratory workups were positive for serum MOG-IgG as assessed by live cell-based assays and the presence of oligoclonal bands in the cerebrospinal fluid (CSF). The patient's serum test results for cytoplasmic-antineutrophil cytoplasmic antibodies, perinuclear-cytoplasmic-antineutrophil cytoplasmic antibodies, GQ1b-antibodies, and aquaporin-4 antibodies (AQP4-IgG) were all negative. Tests for soluble interleukin (IL)-2 receptors in the serum, IL-6 in the CSF and skin pricks, and angiotensin converting enzyme tests were all unremarkable. The patient was diagnosed with MOGAD after receiving an mRNA SARS-CoV-2 vaccination. After two courses of intravenous methylprednisolone treatment, the patient's symptoms improved and her cerebellar peduncle lesion shrunk slightly without gadolinium enhancement. To date, there have only been two cases of monophasic MOGAD following SARS-CoV-2 vaccination, including both the ChAdOx1 nCOV-19 and mRNA-1273 vaccines, and the prognosis is generally similar to other typical MOGAD cases. Although the appearance of MOG antibodies is relatively rare in post-COVID-19–vaccine demyelinating diseases, MOGAD should be considered in patients with central nervous system (CNS) demyelinating diseases after receiving a SARS-CoV-2 vaccine.
RGMa signal in Macrophages Induces Neutrophil-related Astrocytopathy in NMO. International-journal

Shosuke Iwamoto, Takahide Itokazu, Atsushi Sasaki, Hirotoshi Kataoka, Shinji Tanaka, Takeshi Hirata, Keiko Miwa, Toshihiko Suenaga, Yoshiki Takai, Tatsuro Misu, Kazuo Fujihara, Toshihide Yamashita

Annals of neurology　2022/02/15

DOI： 10.1002/ana.26327 　

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OBJECTIVE: Repulsive guidance molecule-a (RGMa) is a glycosylphosphatidylinositol-linked glycoprotein which has multiple functions including axon growth inhibition and immune regulation. However, its role in the pathophysiology of neuromyelitis optica (NMO) is poorly understood. Perivascular astrocytopathy, which is induced by the leakage of aquaporin-4 (AQP4)-specific IgG into the central nervous system parenchyma, is a key feature of NMO pathology. We investigated the RGMa involvement in the pathology of NMO astrocytopathy, and tested a therapeutic potential of humanized anti-RGMa monoclonal antibody (RGMa-mAb). METHODS: Using a clinically relevant NMO rat model, we evaluated the therapeutic effect of a RGMa-mAb by behavioral testing, immunohistochemistry, and gene expression assay. We further performed in vitro experiments to address the RGMa-signaling in macrophages. RESULTS: In both NMO rats and an NMO-autopsied sample, RGMa was expressed by the spared neurons and astrocytes, whereas its receptor neogenin was expressed by infiltrating macrophages. AQP4-IgG-induced astrocytopathy and clinical exacerbation in NMO rats were ameliorated by RGMa-mAb treatment. RGMa-mAb treatment significantly suppressed neutrophil infiltration, and decreased the expression of neutrophil chemoattractants. Interestingly, neogenin-expressing macrophages accumulated in the lesion expressed CXCL2, a strong neutrophil chemoattractant, and further analysis revealed that RGMa directly regulated CXCL2 expression in macrophages. Finally, we found that our NMO rats developed neuropathic pain, and RGMa-mAb treatment effectively ameliorated the severity of neuropathic pain. INTERPRETATION: RGMa signaling in infiltrated macrophages is a critical driver of neutrophil-related astrocytopathy in NMO lesions, and RGMa-mAb may provide an efficient therapeutic strategy for NMO-associated neuropathic pain and motor deficits in patients with NMO. This article is protected by copyright. All rights reserved.
Case Report: Vertebro-vertebral arteriovenous fistula showing symptoms mimicking ALS: Diagnostic imaging supports accurate differentiation between ALS and mimicking conditions. International-journal

Hinako Kirikae, Ryuhei Harada, Tatsuhiko Hosaka, Tatsuro Misu, Daisuke Ando, Hitoshi Warita, Toshiki Endo, Shinya Sonobe, Kuniyasu Niizuma, Masashi Aoki

F1000Research　11　546-546　2022

DOI： 10.12688/f1000research.121554.3 　

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We report a rare case of a vertebro-vertebral arteriovenous fistula (VVAVF) manifesting as amyotrophic lateral sclerosis (ALS). A 76-year-old female patient presented with progressive weakness, muscle atrophy, fasciculation, and preserved deep tendon reflexes in the right upper limb. Electrophysiological testing showed lower motor neuron dysfunction. The patient was suspected to have ALS, but cervical magnetic resonance imaging (MRI) revealed enlarged blood vessels in the spinal canal, which compressed the cervical spinal cord and nerve roots. Angiography showed a shunt from the right vertebral artery to the right intervertebral vein and the vertebral venous plexus; therefore, the patient was diagnosed with VVAVF. Transarterial embolization was performed to obliterate the shunt, and weakness in the patient's right upper limb subsequently improved. It is worth considering VVAVF as a differential diagnosis of ALS-like diseases.
Relapse activity in the chronic phase of anti-myelin-oligodendrocyte glycoprotein antibody-associated disease. International-journal

Tetsuya Akaishi, Tatsuro Misu, Kazuo Fujihara, Toshiyuki Takahashi, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Juichi Fujimori, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima

Journal of neurology　269　(6)　3136-3146　2021/11/25

DOI： 10.1007/s00415-021-10914-x 　

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OBJECTIVE: The patterns of relapse and relapse-prevention strategies for anti-myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are not completely investigated. We compared the patterns of relapse in later stages of MOGAD with those of anti-aquaporin-4 antibody (AQP4-Ab)-positive neuromyelitis optica spectrum disorder (NMOSD). METHODS: In this observational, comparative cohort study, 66 patients with MOGAD and 90 with AQP4-Ab-positive NMOSD were enrolled. We compared the patterns of relapse and annualized relapse rates (ARRs) in the first 10 years from disease onset, stratified by relapse-prevention treatments. RESULTS: Approximately 50% of the patients with MOGAD experienced relapses in the first 10 years. Among those not undergoing relapse-prevention treatments, ARRs in the first 5 years were slightly lower in MOGAD patients than in AQP4-Ab-positive NMOSD patients (MOGAD vs. AQP4-Ab NMOSD: 0.19 vs. 0.30; p = 0.0753). After 5 years, the ARR decreased in MOGAD patients (MOGAD vs. AQP4-Ab NMOSD: 0.05 vs. 0.34; p = 0.0001), with a 72% reduction from the first 5 years (p = 0.0090). Eight (61.5%) of the 13 MOGAD patients with more than 10-year follow-up from disease onset showed relapse 10 years after onset. Clustering in the timing and phenotype of attacks was observed in both disease patients. The effectiveness of long-term low-dose oral PSL for relapse prevention in patients with MOGAD has not been determined. CONCLUSIONS: The relapse risk in patients with MOGAD is generally lower than that in patients with AQP4-Ab-positive NMOSD, especially 5 years after onset. Meanwhile, relapses later than 10 years from onset are not rare in both diseases.
White blood cell count profiles in multiple sclerosis during attacks before the initiation of acute and chronic treatments. International-journal

Tetsuya Akaishi, Tatsuro Misu, Kazuo Fujihara, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Toshiyuki Takahashi, Hiroshi Kuroda, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima, Atsushi Hozawa

Scientific reports　11　(1)　22357-22357　2021/11/16

DOI： 10.1038/s41598-021-01942-8 　

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Multiple sclerosis (MS) is a major demyelinating disease of the central nervous system; however, its exact mechanism is unknown. This study aimed to elucidate the profile of white blood cells (WBCs) in the acute phase of an MS attack. Sixty-four patients with MS at the time of diagnosis and 2492 age- and sex-adjusted healthy controls (HCs) were enrolled. Data regarding the blood cell counts were compared between the groups. The total WBC (p < 0.0001), monocyte (p < 0.0001), basophil (p = 0.0027), and neutrophil (p < 0.0001) counts were higher in the MS group than in the HC group, whereas the lymphocyte and eosinophil counts did not differ. Adjustments for the smoking status and body mass index yielded the same results. The total and differential WBC counts of the patients with MS did not correlate with the counts of T2 hyperintense brain lesions or the levels of neurological disturbance. In summary, patients with MS showed elevated counts of total WBCs, monocytes, basophils, and neutrophils at the time of diagnosis. However, the clinical relevance of these biomarkers in the context of the development and progression of MS remains unclear.
リツキシマブが奏効した妊娠初期抗NMDA受容体脳炎の1例

保坂龍彦, 安藤大祐, 松本勇貴, 小野紘彦, 金子仁彦, 高井良樹, 菅野直人, 三須建郎, 青木正志

神経治療学　38　(6)　S277-S277　2021/10
Publisher: (一社)日本神経治療学会
ISSN： 0916-8443

eISSN： 2189-7824
Five-year visual outcomes after optic neuritis in anti-MOG antibody-associated disease. International-journal

Tetsuya Akaishi, Noriko Himori, Takayuki Takeshita, Tatsuro Misu, Toshiyuki Takahashi, Yoshiki Takai, Shuhei Nishiyama, Juichi Fujimori, Tadashi Ishii, Masashi Aoki, Kazuo Fujihara, Toru Nakazawa, Ichiro Nakashima

Multiple sclerosis and related disorders　56　103222-103222　2021/08/24

DOI： 10.1016/j.msard.2021.103222 　

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INTRODUCTION: Optic neuritis (ON) is a major phenotype of clinical attack related to demyelinating neurological diseases of the central nervous system, including multiple sclerosis (MS), anti-aquaporin-4 (AQP4) antibody-positive neuromyelitis optica spectrum disorder (NMOSD), and anti-myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). As the concept of MOGAD is relatively new, the long-term visual outcomes after ON in MOGAD remains unclear. METHODS: To elucidate the long-term visual prognosis after ON in MOGAD, patients with MOGAD whose visual acuity were regularly followed for more than 5 years from the onset of ON were enrolled. Best-corrected visual acuity (BCVA) at nadir in the acute phase and at 1 and 5 years from onset was evaluated. The data from patients with MOGAD were compared with those from patients with MS or anti-AQP4-positive NMOSD. RESULTS: Twenty-three patients (31 ON-involved eyes) with MOGAD, 20 patients (24 ON-involved eyes) with MS, and 22 patients (24 ON-involved eyes) with anti-AQP4-positive NMOSD were evaluated. All BCVA at nadir, 1 year, and 5 years from the onset of ON were much worse in anti-AQP4-positive NMOSD than in MS (p = 0.0024) and MOGAD (p = 0.0014) patients. In MOGAD and anti-AQP4-positive NMOSD, the serum disease-specific antibody titer was not associated with the subsequent visual prognosis. Visual acuity had almost fully recovered spontaneously or shortly after initiating acute treatment in 22 of the 23 patients with MOGAD-ON. The administration of high-dose intravenous steroid therapy further facilitated early recovery of visual acuity. Meanwhile, a small fraction of patients with extensive optic nerve lesions involving the chiasma irreversibly experienced severe visual impairment despite appropriate acute treatment. CONCLUSION: Although a small fraction of patients with MOGAD who presented with extensive optic nerve lesions experienced irreversible severe visual impairment, the long-term visual outcomes after 5 years from ON in patients with MOGAD were generally as good as that in patients with MS and much better than that in patients with anti-AQP4-positive NMOSD.
Optimal management of neuromyelitis optica spectrum disorder with aquaporin-4 antibody by oral prednisolone maintenance therapy

Yoshiki Takai, Hiroshi Kuroda, Tatsuro Misu, Tetsuya Akaishi, Ichiro Nakashima, Toshiyuki Takahashi, Shuhei Nishiyama, Kazuo Fujihara, Masashi Aoki

Multiple Sclerosis and Related Disorders　49　102750-102750　2021/04
Publisher: Elsevier BV
DOI： 10.1016/j.msard.2021.102750 　

ISSN： 2211-0348
Early Treatment Initiation With Oral Prednisolone for Relapse Prevention Alleviates Depression and Fatigue in Aquaporin-4–Positive Neuromyelitis optica Spectrum Disorder

Tetsuya Akaishi, Toshiyuki Takahashi, Kazuo Fujihara, Tatsuro Misu, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Michiaki Abe, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima

Frontiers in Neurology　12　2021/02/22

DOI： 10.3389/fneur.2021.608149 　

eISSN： 1664-2295
Optic neuritis after ocular trauma in anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder

Tetsuya Akaishi, Noriko Himori, Takayuki Takeshita, Kazuo Fujihara, Tatsuro Misu, Toshiyuki Takahashi, Juichi Fujimori, Tadashi Ishii, Masashi Aoki, Toru Nakazawa, Ichiro Nakashima

BRAIN AND BEHAVIOR　11　(5)　2021/02

DOI： 10.1002/brb3.2083 　

ISSN： 2162-3279
Progression pattern of neurological disability with respect to clinical attacks in anti-MOG antibody-associated disorders

Tetsuya Akaishi, Tatsuro Misu, Toshiyuki Takahashi, Yoshiki Takai, Shuhei Nishiyama, Juichi Fujimori, Tadashi Ishii, Masashi Aoki, Kazuo Fujihara, Ichiro Nakashima

Journal of Neuroimmunology　351　577467-577467　2021/02
Publisher: Elsevier BV
DOI： 10.1016/j.jneuroim.2020.577467 　

ISSN： 0165-5728
Impact of comorbid Sjögren syndrome in anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorders

Tetsuya Akaishi, Toshiyuki Takahashi, Kazuo Fujihara, Tatsuro Misu, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Michiaki Abe, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima

Journal of Neurology　2021/01/08
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s00415-020-10377-6 　

ISSN： 0340-5354

eISSN： 1432-1459
CH50 as a putative biomarker of eculizumab treatment in neuromyelitis optica spectrum disorder

Chihiro Namatame, Tatsuro Misu, Yoshiki Takai, Shuhei Nishiyama, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki

Heliyon　7　(1)　e05899-e05899　2021/01
Publisher: Elsevier BV
DOI： 10.1016/j.heliyon.2021.e05899 　

ISSN： 2405-8440
Seasonal variation of onset in patients with anti-aquaporin-4 antibodies and anti-myelin oligodendrocyte glycoprotein antibody. International-journal

Tetsuya Akaishi, Juichi Fujimori, Toshiyuki Takahashi, Tatsuro Misu, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Ryo Ogawa, Michiaki Abe, Tadashi Ishii, Masashi Aoki, Kazuo Fujihara, Ichiro Nakashima

Journal of neuroimmunology　349　577431-577431　2020/12/15

DOI： 10.1016/j.jneuroim.2020.577431 　

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This study aimed to determine the seasonal impact on the clinical onset of inflammatory neurological diseases of the central nervous system by analyzing the onset month with information on clinical manifestations in Japanese patients. As a result, patients with anti-aquaporin-4 antibodies (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (NMOSD) showed spring-summer predominance of the clinical onset. Conversely, patients with anti-myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease showed autumn-winter predominance of the clinical onset. Both seasonal variations were irrespective of the clinical manifestation. Environmental factors with seasonal variation influence the development of neurological conditions related to AQP4-IgG and MOG-IgG.
Myelin oligodendrocyte glycoprotein-IgG-positive, steroid-responsive combined central and peripheral demyelination with recurrent peripheral neuropathy. International-journal

Takaaki Nakamura, Kimihiko Kaneko, Genya Watanabe, Shogo Harashima, Emiko Kawasaki, Kenichi Tsukita, Toshiyuki Takahashi, Ichiro Nakashima, Tatsuro Misu, Yasushi Suzuki

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology　42　(3)　1135-1138　2020/10/19

DOI： 10.1007/s10072-020-04822-7 　

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Myelin oligodendrocyte glycoprotein (MOG)-IgG detected by the cell-based assay is associated with demyelinating diseases of the central nervous system, such as optic neuritis, myelitis, and acute disseminated encephalomyelitis, but rarely with peripheral neuropathy. Here, we describe the case of a 32-year-old MOG-IgG+ woman who developed central and peripheral demyelinating lesions. In contrast to previous similar cases, she uniquely presented with repeated subsequent relapses in the peripheral nerve, mimicking chronic inflammatory demyelinating polyneuropathy. Possible pathogenic implications of MOG-IgG in combined central and peripheral nervous system diseases are considered.
Rapid Administration of High-Dose Intravenous Methylprednisolone Improves Visual Outcomes After Optic Neuritis in Patients With AQP4-IgG-Positive NMOSD

Tetsuya Akaishi, Takayuki Takeshita, Noriko Himori, Toshiyuki Takahashi, Tatsuro Misu, Ryo Ogawa, Kimihiko Kaneko, Juichi Fujimori, Michiaki Abe, Tadashi Ishii, Kazuo Fujihara, Masashi Aoki, Toru Nakazawa, Ichiro Nakashima

FRONTIERS IN NEUROLOGY　11　2020/09

DOI： 10.3389/fneur.2020.00932 　

ISSN： 1664-2295
Progressive patterns of neurological disability in multiple sclerosis and neuromyelitis optica spectrum disorders. International-journal Peer-reviewed

Tetsuya Akaishi, Toshiyuki Takahashi, Tatsuro Misu, Michiaki Abe, Tadashi Ishii, Juichi Fujimori, Masashi Aoki, Kazuo Fujihara, Ichiro Nakashima

Scientific reports　10　(1)　13890-13890　2020/08/17

DOI： 10.1038/s41598-020-70919-w 　

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The progressive patterns of neurological disability in multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) and the significance of clinical relapses to the progressions of neurological disability in these diseases have not been fully elucidated. In this study, to elucidate the impact of relapses to the progression of accumulated neurological disability and to identify the factors to affect the progression of neurological disability in MS and NMOSD, we followed 62 consecutive MS patients and 33 consecutive NMOSD patients for more than 5 years with the clinical symptoms, relapse occurrence, and Expanded Disability Status Scale (EDSS) in the chronic phase. All enrolled MS patients were confirmed to be negative for serum anti-myelin oligodendrocyte glycoprotein antibody. As a result, patients with NMOSD showed significantly severer neurological disability at 5 years from onset than MS patients. Progression in EDSS score was almost exclusively seen after clinical attacks in NMOSD, whereas progression could be observed apart from relapses in MS. Neurological disability did not change without attacks in NMOSD, whereas it sometimes spontaneously improved or deteriorated apart from relapses in MS (p < 0.001). In patients with MS, those with responsible lesions primarily in spinal cord were more likely to show such spontaneous improvement. In conclusion, clinical deterioration in NMOSD patients is irreversible and almost exclusively takes place at the timing of clinical attacks with stepwise accumulation of neurological disability. Meanwhile, changes in EDSS score can be seen apart from relapses in MS patients. Neurological disability in MS patients is partly reversible, and the patients with disease modifying drugs sometimes present spontaneous improvement of the neurological disability.
Impact of intrathecal IgG synthesis on neurological disability in patients with multiple sclerosis. International-journal Peer-reviewed

Tetsuya Akaishi, Toshiyuki Takahashi, Kazuo Fujihara, Tatsuro Misu, Shuhei Nishiyama, Yoshiki Takai, Juichi Fujimori, Michiaki Abe, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima

Multiple sclerosis and related disorders　45　102382-102382　2020/07/07

DOI： 10.1016/j.msard.2020.102382 　

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BACKGROUND: The association between routine laboratory findings, including cerebrospinal fluid biomarkers, and neurological outcomes in patients with multiple sclerosis (MS) has not been fully elucidated. In this study, we evaluated blood and cerebrospinal fluid (CSF) analysis results at diagnosis and before treatment in patients with MS and assessed their correlations with neurological outcomes. MATERIALS AND METHODS: In this study, 38 consecutive patients with MS (36 with relapsing-remitting MS and 2 with primary progressive MS) were recruited. Before treatment, all patients underwent routine CSF analysis at the time of diagnosis, including evaluation of albumin and immunoglobulin G (IgG) levels. The association between laboratory data and neurological outcomes was comprehensively evaluated. Subsequent neurological outcome was assessed by using the Expanded Disability Status Scale (EDSS) score at 1 year and 5 years after diagnosis and relapse frequency in the first year and in the first 5 years. RESULTS: The IgG level in the CSF (rho = 0.46, p = 0.004), oligoclonal band count (rho = 0.61, p = 0.006), ratio of IgG and total protein in CSF (rho = 0.59, p < 0.0001), and ratio of IgG and albumin in CSF (rho = 0.67, p < 0.0001) showed moderate to strong correlations with the subsequent EDSS score 1 year after diagnosis. These variables still showed significant correlations with EDSS 5 years later. Albumin and lactate dehydrogenase levels in CSF did not correlate with the subsequent EDSS score. Relapse frequency did not correlate with any of the studied serum and CSF biomarkers. CONCLUSION: IgG levels in CSF at MS diagnosis are significantly correlated with the level of neurological disability independent of the relapse frequency. Markers of intrathecal IgG synthesis, such as the IgG index, are useful in estimating the present and subsequent clinical severity in patients with MS.
Risk factors of attacks in neuromyelitis optica spectrum disorders. International-journal Peer-reviewed

Tetsuya Akaishi, Toshiyuki Takahashi, Kazuo Fujihara, Tatsuro Misu, Michiaki Abe, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima

Journal of neuroimmunology　343　577236-577236　2020/06/15

DOI： 10.1016/j.jneuroim.2020.577236 　

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Predisposing factors before the onset of neuromyelitis optica spectrum disorders (NMOSD) have not been systematically evaluated by now. We investigated the detailed pre-onset history in consecutive NMOSD patients. Thirteen of the enrolled 53 NMOSD patients (24.5%) had accompanying autoimmune diseases, such as Sjögren's syndrome. History of malignancy was seen in 8 of the 53 patients (15.1%). Recent history of non-neurological clinical episodes, such as systemic allergic reaction, systemic infection, surgical operation, or traumatic injury, was seen in 23 of the 53 patients (43.4%). NMOSD patients are likely to have pre-onset history of other autoimmune diseases, malignancy, or recent non-neurological systemic conditions, which may predispose or trigger the onset of NMOSD.
Treatment of MOG-IgG-associated disorder with rituximab: An international study of 121 patients. International-journal Peer-reviewed

Daniel H Whittam, Alvaro Cobo-Calvo, A Sebastian Lopez-Chiriboga, Santiago Pardo, Matthew Gornall, Silvia Cicconi, Alexander Brandt, Klaus Berek, Thomas Berger, Ilijas Jelcic, Grace Gombolay, Luana Micheli Oliveira, Dagoberto Callegaro, Kimihiko Kaneko, Tatsuro Misu, Marco Capobianco, Emily Gibbons, Venkatraman Karthikeayan, Bruno Brochet, Bertrand Audoin, Guillaume Mathey, David Laplaud, Eric Thouvenot, Mikaël Cohen, Ayman Tourbah, Elisabeth Maillart, Jonathan Ciron, Romain Deschamps, Damien Biotti, Kevin Rostasy, Rinze Neuteboom, Cheryl Hemingway, Rob Forsyth, Marcelo Matiello, Stewart Webb, David Hunt, Katy Murray, Yael Hacohen, Ming Lim, M Isabel Leite, Jacqueline Palace, Tom Solomon, Andreas Lutterotti, Kazuo Fujihara, Ichiro Nakashima, Jeffrey L Bennett, Lekha Pandit, Tanuja Chitnis, Brian G Weinshenker, Brigitte Wildemann, Douglas Kazutoshi Sato, Su-Hyun Kim, Saif Huda, Ho Jin Kim, Markus Reindl, Michael Levy, Sven Jarius, Silvia Tenembaum, Friedemann Paul, Sean Pittock, Romain Marignier, Anu Jacob

Multiple sclerosis and related disorders　44　102251-102251　2020/06/02

DOI： 10.1016/j.msard.2020.102251 　

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OBJECTIVE: To assess the effect of anti-CD20 B-cell depletion with rituximab (RTX) on relapse rates in myelin oligodendrocyte glycoprotein antibody-associated disorder (MOGAD). METHODS: Retrospective review of RTX-treated MOGAD patients from 29 centres in 13 countries. The primary outcome measure was change in relapse rate after starting rituximab (Poisson regression model). RESULTS: Data on 121 patients were analysed, including 30 (24.8%) children. Twenty/121 (16.5%) were treated after one attack, of whom 14/20 (70.0%) remained relapse-free after median (IQR) 11.2 (6.3-14.1) months. The remainder (101/121, 83.5%) were treated after two or more attacks, of whom 53/101 (52.5%) remained relapse-free after median 12.1 (6.3-24.9) months. In this 'relapsing group', relapse rate declined by 37% (95%CI=19-52%, p<0.001) overall, 63% (95%CI=35-79%, p = 0.001) when RTX was used first line (n = 47), and 26% (95%CI=2-44%, p = 0.038) when used after other steroid-sparing immunotherapies (n = 54). Predicted 1-year and 2-year relapse-free survival was 79% and 55% for first-line RTX therapy, and 38% and 18% for second-/third-line therapy. Circulating CD19+B-cells were suppressed to <1% of total circulating lymphocyte population at the time of 45/57 (78.9%) relapses. CONCLUSION: RTX reduced relapse rates in MOGAD. However, many patients continued to relapse despite apparent B-cell depletion. Prospective controlled studies are needed to validate these results.
Induction of aquaporin 4-reactive antibodies in Lewis rats immunized with aquaporin 4 mimotopes

Irina Tsymala, Magdalini Nigritinou, Bleranda Zeka, Rouven Schulz, Felix Niederschick, Mia Matković, Isabel J. Bauer, Michael Szalay, Kathrin Schanda, Magdalena Lerch, Tatsuro Misu, Kazuo Fujihara, Jeffrey L. Bennett, Charlotte Dahle, Florence Pache, Paulus Rommer, Fritz Leutmezer, Zsolt Illes, Maria Isabel Leite, Jacqueline Palace, Petra Scholze, Markus Reindl, Hans Lassmann, Monika Bradl

Acta Neuropathologica Communications　8　(1)　2020/04/15
Publisher: BioMed Central Ltd.
DOI： 10.1186/s40478-020-00920-x 　

ISSN： 2051-5960
Serum AQP4-IgG level is associated with the phenotype of the first attack in neuromyelitis optica spectrum disorders. International-journal Peer-reviewed

Tetsuya Akaishi, Toshiyuki Takahashi, Noriko Himori, Kazuo Fujihara, Tatsuro Misu, Michiaki Abe, Tadashi Ishii, Toru Nakazawa, Masashi Aoki, Ichiro Nakashima

Journal of neuroimmunology　340　577168-577168　2020/03/15

DOI： 10.1016/j.jneuroim.2020.577168 　

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We aimed in this study to elucidate the impact of serum AQP4-IgG titer before starting treatments to the clinical manifestation of neuromyelitis optica spectrum disorders (NMOSD). Serum titer at the onset, measured using live cell-based assay method, did not correlate to the subsequent relapse rate or neurological prognosis. Patients with optic neuritis as the first attack showed significantly higher serum titer than patients with acute myelitis or area postrema syndrome, although the titer did not correlate to the visual prognosis. The result implies that the pathological mechanism of optic neuritis and acute myelitis could be different in NMOSD.
Myelin oligodendrocyte glycoprotein immunoglobulin G-associated disease

Kimihiko Kaneko, Toshiyuki Takahashi, Tatsuro Misu, Ichiro Nakashima, Kazuo Fujihara

Clinical and Experimental Neuroimmunology　11　(1)　28-33　2020/03/01
Publisher: Wiley-Blackwell
DOI： 10.1111/cen3.12578 　

ISSN： 1759-1961
Rapid Administration of High-Dose Intravenous Methylprednisolone Improves Visual Outcomes After Optic Neuritis in Patients With AQP4-IgG-Positive NMOSD. International-journal

Tetsuya Akaishi, Takayuki Takeshita, Noriko Himori, Toshiyuki Takahashi, Tatsuro Misu, Ryo Ogawa, Kimihiko Kaneko, Juichi Fujimori, Michiaki Abe, Tadashi Ishii, Kazuo Fujihara, Masashi Aoki, Toru Nakazawa, Ichiro Nakashima

Frontiers in neurology　11　932-932　2020

DOI： 10.3389/fneur.2020.00932 　

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Objective: The purpose of this study was to elucidate the rapid impact of high-dose intravenous methylprednisolone pulse therapy (1,000 mg/day for 3 days) on the eventual visual prognosis in patients with serum anti-aquaporin-4 immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (NMOSDs) who had an attack of optic neuritis (ON). Methods: Data from 32 consecutive NMOSD patients (1 male and 31 female) with at least one ON attack, involving a total of 36 ON-involved eyes, were evaluated. The following variables at ON onset were evaluated: sex, age at the first ON episode, visual acuity at nadir, visual acuity after 1 year, duration from ON onset to treatment for an acute ON attack, cycles of high-dose intravenous methylprednisolone pulse therapy for the ON attack, and cycles of plasmapheresis for the ON attack. Among the 36 ON-involved eyes, 27 eyes were studied using orbital MRI with a short-T1 inversion recovery sequence and gadolinium-enhanced fat-suppressed T1 imaging before starting treatment in the acute phase. Results: In univariate analyses, a shorter duration from ON onset to the initiation of high-dose intravenous methylprednisolone pulse therapy favorably affected the eventual visual prognosis 1 year later (Spearman's rho = 0.50, p = 0.0018). The lesion length on orbital MRI was also correlated with the eventual visual prognosis (rho = 0.68, p < 0.0001). Meanwhile, the days to steroid pulse therapy and lesion length on orbital MRI did not show a significant correlation. These findings suggest that the rapidness of steroid pulse therapy administration affects the eventual visual prognosis independent of the severity of ON. In multivariate analysis, a shorter time from ON onset to the start of acute treatment (p = 0.0004) and a younger age at onset (p = 0.0071) were significantly associated with better visual outcomes. Conclusions: Rapid initiation of high-dose intravenous methylprednisolone pulse therapy is essential to preserve the eventual visual acuity in patients with serum AQP4-IgG-positive NMOSD. Once clinicians suspect acute ON with serum AQP4-IgG, swift administration of steroid pulse therapy before confirming the positivity of serum AQP4-IgG would be beneficial for preserving visual function.
Number of MRI T1-hypointensity corrected by T2/FLAIR lesion volume indicates clinical severity in patients with multiple sclerosis. International-journal Peer-reviewed

Tetsuya Akaishi, Toshiyuki Takahashi, Kazuo Fujihara, Tatsuro Misu, Shunji Mugikura, Michiaki Abe, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima

PloS one　15　(4)　e0231225　2020

DOI： 10.1371/journal.pone.0231225 　

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INTRODUCTION: Progressive brain atrophy, development of T1-hypointense areas, and T2-fluid-attenuated inversion recovery (FLAIR)-hyperintense lesion formation in multiple sclerosis (MS) are popular volumetric data that are often utilized as clinical outcomes. However, the exact clinical interpretation of these volumetric data has not yet been fully established. METHODS: We enrolled 42 consecutive patients with MS who fulfilled the revised McDonald criteria of 2010. They were followed-up for more than 3 years from onset, and cross-sectional brain volumetry was performed. Patients with no brain lesions were excluded in advance from this study. For the brain volumetric data, we evaluated several parameters including age-adjusted gray-matter volume atrophy, age-adjusted white-matter volume atrophy, and T2-FLAIR lesion volume. The numbers of T1-hypointense and T2-FLAIR-hyperintense areas were also measured along the same timeline. The clinical data pertaining to disease duration, expanded disability status scale (EDSS), and MS severity score (MSSS) at the timing of volumetry were collected. RESULTS: Among the 42 patients with MS and brain lesions, the number of T1-hypointensity (rho = 0.51, p<0.001), gray-matter atrophy (rho = 0.40, p<0.01) and white-matter atrophy (rho = 0.49, p<0.001) correlated with the EDSS. T1-hypointensity count divided by FLAIR lesion volume correlated with the MSSS (rho = 0.60, p<0.001). Meanwhile, counts or volumes of FLAIR-hyperintense lesions were associated only with the times of past relapses, and did not correlate with present neurological disability level or ongoing disease activity. These findings were consistent regardless of the presence of spinal cord lesions. CONCLUSION: Numbers of T1-hypointensities and brain atrophy equally indicated the current neurological disability in MS. The number of T1-hypointensities divided by FLAIR lesion volume represented the clinical severity. The size or number of FLAIR lesions reflected earlier relapses but was not a good indicator of neurological disability or clinical severity.
T-cell Lymphoma Presenting Neutrophilic Inflammation in the Cerebrospinal Fluid: A Case Report. Peer-reviewed

Nakamura T, Takai Y, Kaneko K, Kuroda H, Misu T, Asanuma K, Saito R, Aoki M

Internal medicine (Tokyo, Japan)　2019/10

DOI： 10.2169/internalmedicine.3093-19 　

ISSN： 0918-2918
Two Japanese cases of anti-MOG antibody-associated encephalitis that mimicked neuro-Behçet's disease. Peer-reviewed

Fujimori J, Takahashi T, Matsumoto Y, Fujihara K, Takai Y, Misu T, Nakashima I

Journal of neuroimmunology　334　577002　2019/09

DOI： 10.1016/j.jneuroim.2019.577002 　

ISSN： 0165-5728
A case of neuralgic amyotrophy presented Vernet syndrome and suprascapular nerve palsy Peer-reviewed

Iino Akira, Sugeno Naoto, Namatame Chihiro, Nishiyama Ayumi, Kuroda Hiroshi, Misu Tatsuro, Aoki Masashi

NEUROLOGY AND CLINICAL NEUROSCIENCE　7　(3)　127-128　2019/05

DOI： 10.1111/ncn3.12264 　

ISSN： 2049-4173
Debate on the treatment of multiple sclerosis: Experience from an intractable multiple sclerosis case with rebound syndrome after fingolimod cessation

Hiroshi Kuroda, Shuhei Nishiyama, Yuki Matsumoto, Tatsuro Misu, Kazuo Fujihara, Masashi Aoki

Clinical and Experimental Neuroimmunology　10　(S1)　59-62　2019/03

DOI： 10.1111/cen3.12504 　

eISSN： 1759-1961
Transient Pulmonary Interstitial Lesions in Aquaporin-4-positive Neuromyelitis Optica Spectrum Disorder. Peer-reviewed

Asato Y, Kamitani T, Ootsuka K, Kuramochi M, Nakanishi K, Shimada T, Takahashi T, Misu T, Aoki M, Fujihara K, Kawabata Y

Internal medicine (Tokyo, Japan)　57　(20)　2981-2986　2018/10

DOI： 10.2169/internalmedicine.0580-17 　

ISSN： 0918-2918
The pathological features of MOG antibody-positive cerebral cortical encephalitis as a new spectrum associated with MOG antibodies: A case report. International-journal Peer-reviewed

Ikeda T, Yamada K, Ogawa R, Takai Y, Kaneko K, Misu T, Kamimoto K, Matsukawa N, Yoshida M

Journal of the neurological sciences　392　113-115　2018/09

DOI： 10.1016/j.jns.2018.06.028 　

ISSN： 0022-510X
Myelin oligodendrocyte glycoprotein immunoglobulin G-associated disease: An overview

Kazuo Fujihara, Kazuo Fujihara, Kazuo Fujihara, Douglas K. Sato, Douglas K. Sato, Ichiro Nakashima, Ichiro Nakashima, Toshiyuki Takahashi, Toshiyuki Takahashi, Kimihiko Kaneko, Ryo Ogawa, Tetsuya Akaishi, Yuki Matsumoto, Yoshiki Takai, Shuhei Nishiyama, Hiroshi Kuroda, Tatsuro Misu, Tatsuro Misu, Masashi Aoki

Clinical and Experimental Neuroimmunology　9　48-55　2018/03/01

DOI： 10.1111/cen3.12434 　
Impact of the Great East Japan Earthquake in 2011 on MS and NMOSD: a study in Sendai, Japan Peer-reviewed

Kanamori, Yoko, Nakashima, Ichiro, Takai, Yoshiki, Misu, Tatsuro, Kuroda, Hiroshi, Nishiyama, Shuhei, Takahashi, Toshiyuki, Sato, Shigeru, Fujimori, Juichi, Higuchi, Jun, Itoyama, Yasuto, Aoki, Masashi, Fujihara, Kazuo

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY　88　(4)　362-+　2017/04

DOI： 10.1136/jnnp-2016-313890 　

ISSN： 0022-3050

eISSN： 1468-330X
Elevated Cerebrospinal Fluid-CRMP5 As A Biomarker of Damage to Astrocyte Foot Process and Growth Corn in AQP4-Igg-Seropositve NMOSD Peer-reviewed

Shuhei Nishiyama, Tatsuro Misu, Ichiro Nakashima, Toshiyuki Takahashi, Kazuo Fujihara, Masashi Aoki

MULTIPLE SCLEROSIS JOURNAL　23　(2)　319-320　2017/02

ISSN： 1352-4585

eISSN： 1477-0970
Pregnancy-related relapse risk factors in women with anti-AQP4 antibody positivity and neuromyelitis optica spectrum disorder Peer-reviewed

Yuko Shimizu, Kazuo Fujihara, Takashi Ohashi, Ichiro Nakashima, Kazumasa Yokoyama, Ryotaro Ikeguch, Toshiyuki Takahashi, Tatsuro Misu, Satoru Shimizu, Masashi Aoki, Kazuo Kitagawa

MULTIPLE SCLEROSIS JOURNAL　22　(11)　1413-1420　2016/10

DOI： 10.1177/1352458515583376 　

ISSN： 1352-4585

eISSN： 1477-0970
Aquaporin 4-specific T cells and NMO-IgG cause primary retinal damage in experimental NMO/SD Peer-reviewed

Bleranda Zeka, Maria Hastermann, Nathalie Kaufmann, Kathrin Schanda, Marko Pende, Tatsuro Misu, Paulus Rommer, Kazuo Fujihara, Ichiro Nakashima, Charlotte Dahle, Fritz Leutmezer, Markus Reindl, Hans Lassmann, Monika Bradl

ACTA NEUROPATHOLOGICA COMMUNICATIONS　4　(1)　82　2016/08

DOI： 10.1186/s40478-016-0355-y 　

ISSN： 2051-5960
MRI and retinal abnormalities in isolated optic neuritis with myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies: a comparative study Peer-reviewed

Tetsuya Akaishi, Douglas Kazutoshi Sato, Ichiro Nakashima, Takayuki Takeshita, Toshiyuki Takahashi, Hiroshi Doi, Kazuhiro Kurosawa, Kimihiko Kaneko, Hiroshi Kuroda, Shuhei Nishiyama, Tatsuro Misu, Toru Nakazawa, Kazuo Fujihara, Masashi Aoki

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY　87　(4)　446-+　2016/04

DOI： 10.1136/jnnp-2014-310206 　

ISSN： 0022-3050

eISSN： 1468-330X
Lesion length of optic neuritis impacts visual prognosis in neuromyelitis optica Peer-reviewed

Tetsuya Akaishi, Ichiro Nakashima, Takayuki Takeshita, Shunji Mugikura, Douglas Kazutoshi Sato, Toshiyuki Takahashi, Shuhei Nishiyama, Kazuhiro Kurosawa, Tatsuro Misu, Toru Nakazawa, Masashi Aoki, Kazuo Fujihara

JOURNAL OF NEUROIMMUNOLOGY　293　28-33　2016/04

DOI： 10.1016/j.jneuroim.2016.02.004 　

ISSN： 0165-5728

eISSN： 1872-8421
High avidity chimeric monoclonal antibodies against the extracellular domains of human aquaporin-4 competing with the neuromyelitis optica autoantibody, NMO-IgG Peer-reviewed

Kaori Miyazaki-Komine, Yoshiki Takai, Ping Huang, Osamu Kusano-Arai, Hiroko Iwanari, Tatsuro Misu, Katsushi Koda, Katsuyuki Mitomo, Toshiko Sakihama, Yoshiaki Toyama, Kazuo Fujihara, Takao Hamakubo, Masato Yasui, Yoichiro Abe

BRITISH JOURNAL OF PHARMACOLOGY　173　(1)　103-114　2016/01

DOI： 10.1111/bph.13340 　

ISSN： 0007-1188

eISSN： 1476-5381
Leukoencephalopathy resolution after atypical mycobacterial treatment: a case report Peer-reviewed

Marcos C. B. Oliveira, Douglas Kazutoshi Sato, Herval R. Soares-Neto, Leandro T. Lucato, Dagoberto Callegaro, Ricardo Nitrini, Raphael S. S. Medeiros, Tatsuro Misu, Kazuo Fujihara, Luiz H. Castro

BMC NEUROLOGY　15　159　2015/09

DOI： 10.1186/s12883-015-0415-0 　

ISSN： 1471-2377
Acute callosal disconnection syndrome as an initial manifestation of neuromyelitis optica spectrum disorders Peer-reviewed

Kobayashi Junpei, Kuroda Hiroshi, Ezura Michinori, Sugeno Naoto, Shibui Aya, Takahashi Toshiyuki, Misu Tatsuro, Fujihara Kazuo, Mori Etsuro, Aoki Masashi

NEUROLOGY AND CLINICAL NEUROSCIENCE　3　(4)　137-139　2015/07

DOI： 10.1111/ncn3.164 　

ISSN： 2049-4173
MOG cell-based assay detects non-MS patients with inflammatory neurologic disease Peer-reviewed

Patrick Waters, Mark Woodhall, Kevin C. O'Connor, Markus Reindl, Bethan Lang, Douglas K. Sato, MacIej Jurynczyk, George Tackley, Joao Rocha, Toshiyuki Takahashi, Tatsuro Misu, Ichiro Nakashima, Jacqueline Palace, Kazuo Fujihara, M. Isabel Leite, Angela Vincent

Neurology: Neuroimmunology and NeuroInflammation　2　(3)　e89　2015/06/01
Publisher: Lippincott Williams and Wilkins
DOI： 10.1212/NXI.0000000000000089 　

ISSN： 2332-7812
Depressive state and chronic fatigue in multiple sclerosis and neuromyelitis optica Peer-reviewed

Tetsuya Akaishi, Ichiro Nakashima, Tatsuro Misu, Kazuo Fujihara, Masashi Aoki

JOURNAL OF NEUROIMMUNOLOGY　283　70-73　2015/06

DOI： 10.1016/j.jneuroim.2015.05.007 　

ISSN： 0165-5728

eISSN： 1872-8421
Multiple sclerosis in Japan appears to be a milder disease compared to the UK Peer-reviewed

L. Piccolo, G. Kumar, I. Nakashima, T. Misu, Y. Kong, B. Wakerley, S. Ryan, A. Cavey, K. Fujihara, Jacqueline Palace

JOURNAL OF NEUROLOGY　262　(4)　831-836　2015/04

DOI： 10.1007/s00415-015-7637-3 　

ISSN： 0340-5354

eISSN： 1432-1459
Severe demyelination but no astrocytopathy in clinically definite neuromyelitis optica with anti-myelin-oligodendrocyte glycoprotein antibody Peer-reviewed

Kensuke Ikeda, Naoki Kiyota, Hiroshi Kuroda, Douglas Kazutoshi Sato, Shuhei Nishiyama, Toshiyuki Takahashi, Tatsuro Misu, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki

MULTIPLE SCLEROSIS JOURNAL　21　(5)　656-659　2015/04

DOI： 10.1177/1352458514551455 　

ISSN： 1352-4585

eISSN： 1477-0970
AQP4 in biopsied demyelinating lesions as a diagnostic clue to NMOSD and MS Final answer? Peer-reviewed

Kazuo Fujihara, Tatsuro Misu

NEUROLOGY　84　(2)　110-111　2015/01

DOI： 10.1212/WNL.0000000000001135 　

ISSN： 0028-3878

eISSN： 1526-632X
Clinical values of FDG PET in polymyositis and dermatomyositis syndromes: imaging of skeletal muscle inflammation Peer-reviewed

Maki Tateyama, Kazuo Fujihara, Tatsuro Misu, Akira Arai, Tomohiro Kaneta, Masashi Aoki

BMJ OPEN　5　(1)　e006763　2015

DOI： 10.1136/bmjopen-2014-006763 　

ISSN： 2044-6055
[Clinical characteristics of four patients with temporal lobe epilepsy associated with elevated anti-GAD antibodies]. Peer-reviewed

Tetsuya Akaishi, Kazutaka Jin, Kazuhiro Kato, Hisashi Itabashi, Tatsuro Misu, Maki Tateyama, Masaki Iwasaki, Masashi Aoki, Nobukazu Nakasato

Rinsho shinkeigaku = Clinical neurology　55　(11)　804-9　2015

DOI： 10.5692/clinicalneurol.cn-000740 　

ISSN： 0009-918X

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Anti-glutamic acid decarboxylase (GAD) antibodies are known to be associated with insulin-dependent diabetes mellitus (IDDM), stiff-person syndrome, and other neurological symptoms including temporal lobe epilepsy (TLE), known as autoimmune epilepsy. We treated four patients with TLE who had elevated titers of serum anti-GAD antibody (anti-GAD-Ab), higher than 100 U/ml. Three of the four patients started to have epileptic seizures in their 5th or 6th decade. Characteristic symptoms suggesting encephalitis or encephalopathy were absent at onset of these symptoms, which led to delayed diagnosis. All four patients developed two or three of cerebellar ataxia, neuropsychological impairment, and IDDM, by several years or decades after onset of TLE, even after seizure freedom in two patients. These abnormalities were indicators for suspecting the involvement of anti-GAD-Ab in the pathogenesis. Anti-GAD-Ab levels in the cerebrospinal fluid (CSF) were measured, which detected elevated CSF/serum anti-GAD-Ab ratio (≥ 1.0), suggesting intrathecal anti-GAD-Ab synthesis, in three of the four patients. The TLE symptoms were somewhat prolonged, but three of the four patients eventually achieved seizure freedom after immunotherapies with combinations of two or three anti-epileptic drugs. Serum anti-GAD Ab is recommended to be measured in patients with middle-aged onset TLE. Moreover, immune-modulating therapies including steroid pulse and intravenous immunoglobulin therapies could have ameliorated neurological complications, even in the chronic phase.
Audiological evidence of therapeutic effect of steroid treatment in neuromyelitis optica with hearing loss Peer-reviewed

Yoshitaka Takanashi, Tatsuro Misu, Kazuha Oda, Hiromitsu Miyazaki, Izumi Yahata, Hiroshi Hidaka, Kazuo Fujihara, Tetsuaki Kawase, Toshimitsu Kobayashi, Yukio Katori

JOURNAL OF CLINICAL NEUROSCIENCE　21　(12)　2249-2251　2014/12

DOI： 10.1016/j.jocn.2014.04.019 　

ISSN： 0967-5868

eISSN： 1532-2653
PREGNANCY OUTCOME IN AQUAPORIN-4 POSITIVE NEUROMYELITIS OPTICA SPECTRUM DISORDER: A MULTI-CENTER RETROSPECTIVE COHORT STUDY Peer-reviewed

Nour Matthew, Coutinho Esther, Nakashima Ichiro, Sousa Filipa, Woodhall Mark, Revis John, Santos Ernestina, George Jithin, Kitley Joana, Misu T, Silva A. M, Vincent Angela, Palace Jacqueline, Waters Paddy, Fujihara K, Leite Maria

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY　85　(10)　2014/10

DOI： 10.1136/jnnp-2014-309236.165 　

ISSN： 0022-3050
A Case Series of Longitudinally Extended Transverse Myelitis with Increased Polymorphonuclear Leukocytes in CSF Peer-reviewed

Hiroshi Kuroda, Toshiyuki Takahashi, Douglas Kazutoshi Sato, Ayumi Nishiyama, Emiko Miura, Shuhei Nishiyama, Naoto Sugeno, Tatsuro Misu, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki

MULTIPLE SCLEROSIS JOURNAL　20　(7)　953-953　2014/06

ISSN： 1352-4585

eISSN： 1477-0970
Anti-MOG Antibodies in Japanese Patients with Neuromyelitis Optica Spectrum Disorders Peer-reviewed

Sato Douglas Kazutoshi, Nakashima Ichiro, Takahashi Toshiyuki, Misu Tatsuro, Kuroda Hiroshi, Nishiyama Shuhei, Waters Patrick, Fujihara Kazuo

MULTIPLE SCLEROSIS JOURNAL　20　(7)　943　2014/06

ISSN： 1352-4585
Aquaporin-4 antibody-positive myelitis initially biopsied for suspected spinal cord tumors: Diagnostic considerations Peer-reviewed

Douglas Kazutoshi Sato, Tatsuro Misu, Cristiane Franklin Rocha, Dagoberto Callegaro, Ichiro Nakashima, Masashi Aoki, Kazuo Fujihara, Marco Aurelio Lana-Peixoto

MULTIPLE SCLEROSIS JOURNAL　20　(5)　621-626　2014/04

DOI： 10.1177/1352458513505350 　

ISSN： 1352-4585

eISSN： 1477-0970
Changes in Th17 and regulatory T cells after fingolimod initiation to treat multiple sclerosis Peer-reviewed

Douglas Kazutoshi Sato, Ichiro Nakashima, Amit Bar-Or, Tatsuro Misu, Chihiro Suzuki, Shuhei Nishiyama, Hiroshi Kuroda, Kazuo Fujihara, Masashi Aoki

JOURNAL OF NEUROIMMUNOLOGY　268　(1-2)　95-98　2014/03

DOI： 10.1016/j.jneuroim.2014.01.008 　

ISSN： 0165-5728

eISSN： 1872-8421
Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders Peer-reviewed

Douglas Kazutoshi Sato, Dagoberto Callegaro, Marco Aurelio Lana-Peixoto, Patrick J. Waters, Frederico M. de Haidar Jorge, Toshiyuki Takahashi, Ichiro Nakashima, Samira Luisa Apostolos-Pereira, Natalia Talim, Renata Faria Simm, Angelina Maria Martins Lino, Tatsuro Misu, Maria Isabel Leite, Masashi Aoki, Kazuo Fujihara

NEUROLOGY　82　(6)　474-481　2014/02

DOI： 10.1212/WNL.0000000000000101 　

ISSN： 0028-3878

eISSN： 1526-632X
Intrastriatal injection of interleukin-1 beta triggers the formation of neuromyelitis optica-like lesions in NMO-IgG seropositive rats Peer-reviewed

Maja Kitic, Sonja Hochmeister, Isabella Wimmer, Jan Bauer, Tatsuro Misu, Simone Mader, Markus Reindl, Kazuo Fujihara, Hans Lassmann, Monika Bradl

Acta Neuropathologica Communications　2　(1)　5　2014/01/27
Publisher: BioMed Central Ltd.
DOI： 10.1186/2051-5960-1-5 　

ISSN： 2051-5960
T cell-activation in neuromyelitis optica lesions plays a role in their formation Peer-reviewed

Maria Pohl, Naoto Kawakami, Maja Kitic, Jan Bauer, Rui Martins, Marie-Therese Fischer, Joana Machado-Santos, Simone Mader, Joachim W. Ellwart, Tatsuro Misu, Kazuo Fujihara, Hartmut Wekerle, Markus Reindl, Hans Lassmann, Monika Bradl

Acta Neuropathologica Communications　2　(1)　85　2014/01/27
Publisher: BioMed Central Ltd.
DOI： 10.1186/2051-5960-1-85 　

ISSN： 2051-5960
An autopsy case involving a 12-year history of amyotrophic lateral sclerosis with CIDP-like polyneuropathy. Peer-reviewed

Tetsuya Akaishi, Maki Tateyama, Kazuhiro Kato, Emiko Miura, Rumiko Izumi, Kaoru Endo, Naoto Sugeno, Naoki Suzuki, Toru Baba, Tatsuro Misu, Akio Kikuchi, Takafumi Hasegawa, Sachiko Konosu-Fukaya, Fumiyoshi Fujishima, Hiroyoshi Suzuki, Ichiro Nakashima, Masashi Aoki

Internal medicine (Tokyo, Japan)　53　(12)　1371-5　2014

DOI： 10.2169/internalmedicine.53.0774 　

ISSN： 0918-2918

eISSN： 1349-7235

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Demyelinating polyneuropathy associated with amyotrophic lateral sclerosis (ALS) is quite rare. We herein present the case of a woman patient with a 12-year history of chronic inflammatory demyelinating polyneuropathy (CIDP)-like polyneuropathy who later developed bulbar palsy and respiratory failure. The autopsy findings revealed neuronal loss in the anterior horn and primary motor cortex with degeneration of the corticospinal tracts. Diffuse phosphorylated TAR DNA-binding protein of 43 kDa inclusions were observed in the anterior horn and cerebral cortices, including the temporal lobe. The final diagnosis was ALS with CIDP-like polyneuropathy. Compared with other reports of ALS with CIDP-like polyneuropathy, the present patient was younger and followed a relatively long clinical course, with no upper motor neuron signs.
A novel monoclonal antibody against the C-terminal region of aquaporin-4. Peer-reviewed

Ramadhanti J, Huang P, Kusano-Arai O, Iwanari H, Sakihama T, Misu T, Fujihara K, Hamakubo T, Yasui M, Abe Y

Monoclon. Antib. Immunodiagn. Immunother.　32　(4)　270-276　2013/08

DOI： 10.1089/mab.2013.0007 　
Hereditary neuropathy with liability to pressure palsy emerging after hypothyroidism. Peer-reviewed

Kimihiko Kaneko, Naoto Sugeno, Maki Tateyama, Tatsuro Misu, Naoki Suzuki, Masashi Aoki

Neurol. Clin. Neurosci.　1　(4)　160-161　2013/07
The Importance of Aquaporin-4 Antibody Assays in Patients beyond the Diagnostic Criteria for Neuromyelitis Optica Spectrum Disorders Peer-reviewed

Douglas Sato, Ichiro Nakashima, Toshiyuki Takahashi, Tatsuro Misu, Patrick Waters, Hiroshi Kuroda, Shuhei Nishiyama, Chihiro Suzuki, Yoshiki Takai, Yasuto Itoyama, Kazuo Fujihara, Masashi Aoki

NEUROLOGY　80　2013/02

DOI： 10.1177/1352458512472748 　

ISSN： 0028-3878

eISSN： 1526-632X
Increase of complement fragment C5a in cerebrospinal fluid during exacerbation of neuromyelitis optica Peer-reviewed

Hiroshi Kuroda, Kazuo Fujihara, Rina Takano, Yoshiki Takai, Toshiyuki Takahashi, Tatsuro Misu, Ichiro Nakashima, Shigeru Sato, Yasuto Itoyama, Masashi Aoki

JOURNAL OF NEUROIMMUNOLOGY　254　(1-2)　178-182　2013/01

DOI： 10.1016/j.jneuroim.2012.09.002 　

ISSN： 0165-5728

eISSN： 1872-8421
Neutralizing Antibodies Are Associated with a Reduction of Interferon-beta Efficacy during the Treatment of Japanese Multiple Sclerosis Patients Peer-reviewed

Douglas Kazutoshi Sato, Ichiro Nakashima, Toshiyuki Fukazawa, Yuko Shimizu, Yuji Tomizawa, Kazumasa Yokoyama, Tatsuro Misu, Paul I. Creeke, Rachel Farrell, Gavin Giovannoni, Yasuto Itoyama, Kazuo Fujihara, Masashi Aoki

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　228　(2)　85-92　2012/10

DOI： 10.1620/tjem.228.85 　

ISSN： 0040-8727

eISSN： 1349-3329
Two cases of elderly-onset hereditary neuropathy with liability to pressure palsy manifesting bilateral peroneal nerve palsies. International-journal Peer-reviewed

Norihiko Kawaguchi, Naoki Suzuki, Maki Tateyama, Yoshiki Takai, Tatsuro Misu, Ichiro Nakashima, Yasuto Itoyama, Masashi Aoki

Case reports in neurology　4　(3)　149-55　2012/09

DOI： 10.1159/000342132 　

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Hereditary neuropathy with liability to pressure palsy (HNPP) is characterized by recurrent focal neuropathies, which usually become symptomatic in the second or third decade of life. However, clinical phenotypic heterogeneity among patients with HNPP has recently been reported. Certain patients show polyneuropathy-type diffuse nerve injuries, whereas others remain asymptomatic at older ages. We present two cases of elderly-onset bilateral peroneal nerve palsies with diffuse muscle weakness in the lower limbs and glove-and-stocking type sensory disturbance. Both patients were diagnosed with HNPP by genetic analyses that detected deletions of chromosome 17p11.2 in peripheral myelin protein 22 genes. Their clinical courses suggested that the Japanese sitting style termed 'seiza', a way of sitting on the floor with the lower legs crossed under the thighs, was a precipitating factor for the bilateral peroneal nerve palsies.
A case of recurrent encephalomyelitis associated with eosinophilia in CSF Peer-reviewed

Jun Suzuki, Naoto Sugeno, Shuhei Nishiyama, Kimihiko Kaneko, Tatsuro Misu, Maki Tateyama, Toshiki Endo, Masashi Aoki

Clinical Neurology　52　(8)　571-575　2012/08

DOI： 10.5692/clinicalneurol.52.571 　

ISSN： 0009-918X
Neuromyelitis optica should be classified as an astrocytopathic disease rather than a demyelinating disease

Kazuo Fujihara, Tatsuro Misu, Ichiro Nakashima, Toshiyuki Takahashi, Monika Bradl, Hans Lassmann, Rina Takano, Shuhei Nishiyama, Yoshiki Takai, Chihiro Suzuki, Douglas Sato, Hiroshi Kuroda, Masashi Nakamura, Juichi Fujimori, Koichi Narikawa, Shigeru Sato, Yasuto Itoyama, Masashi Aoki

Clinical and Experimental Neuroimmunology　3　(2)　58-73　2012/05

DOI： 10.1111/j.1759-1961.2012.00030.x 　

eISSN： 1759-1961
Pathological study of subacute autoimmune encephalopathy with anti-AQP4 antibodies in a pregnant woman Peer-reviewed

Hiroaki Yaguchi, Ichiro Yabe, Yoshiki Takai, Tatsuro Misu, Masaaki Matsushima, Toshiyuki Takahashi, Kanako C. Kubota, Sachiko Akimoto, Kazuo Fujihara, Hidenao Sasaki

MULTIPLE SCLEROSIS JOURNAL　18　(5)　683-687　2012/05

DOI： 10.1177/1352458511422928 　

ISSN： 1352-4585
Pathological study of subacute autoimmune encephalopathy with anti-AQP4 antibodies in a pregnant woman Peer-reviewed

Hiroaki Yaguchi, Ichiro Yabe, Yoshiki Takai, Tatsuro Misu, Masaaki Matsushima, Toshiyuki Takahashi, Kanako C. Kubota, Sachiko Akimoto, Kazuo Fujihara, Hidenao Sasaki

MULTIPLE SCLEROSIS JOURNAL　18　(5)　683-687　2012/05

DOI： 10.1177/1352458511422928 　

ISSN： 1352-4585
The Effect of NMO-IgG and Complement Against Primary Human Astrocytes in Culture Peer-reviewed

Nishiyama Shuhei, Misu Tatsuro, Sugeno Naoto, Takahashi Toshiyuki, Nakashima Ichiro, Itoyama Yasuto, Aoki Masashi, Fujihara Kazuo

NEUROLOGY　78　2012/04

ISSN： 0028-3878
Recurrent hypogeusia in a patient with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) Peer-reviewed

Norihiko Kawaguchi, Naoto Sugeno, Kaoru Endo, Emiko Miura, Tatsuro Misu, Ichiro Nakashima, Yasuto Itoyama

JOURNAL OF CLINICAL NEUROSCIENCE　19　(4)　604-605　2012/04

DOI： 10.1016/j.jocn.2011.06.027 　

ISSN： 0967-5868
Therapeutic Efficacy of Interferon beta-1b in Japanese Patients with Optic-Spinal Multiple Sclerosis Peer-reviewed

Yuko Shimizu, Kazuo Fujihara, Sachiko Kubo, Toshiyuki Takahashi, Tatsuro Misu, Ichiro Nakashima, Kazumasa Yokoyama, Yasuto Itoyamas, Shinichiro Uchiyama

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　223　(3)　211-214　2011/03

DOI： 10.1620/tjem.223.211 　

ISSN： 0040-8727

eISSN： 1349-3329
Astrocyte lesion and secondary demyelination: The lesson from neuromyelitis optica Peer-reviewed

Tatsuro Misu, Hans Lassmann, Yoshiki Takai, Shuhei Nishiyama, Toshiyuki Takahashi, Ichiro Nakashima, Masashi Aoki, Yasuto Itoyama, Kazuo Fujihara

NEUROSCIENCE RESEARCH　71　E53-E54　2011

DOI： 10.1016/j.neures.2011.07.227 　

ISSN： 0168-0102
The effect of complement of different species against human primary astrocyte Peer-reviewed

Nishiyama Shuhei, Misu Tatsuro, Nuriya Mutsuo, Takahashi Toshiyuki, Nakashima Ichiro, Yasui Masato, Fujihara Kazuo, Itoyama Yasuto

NEUROSCIENCE RESEARCH　71　E365　2011

DOI： 10.1016/j.neures.2011.07.1603 　

ISSN： 0168-0102
Epitope analysis of cerebrospinal fluid IgG in Japanese multiple sclerosis patients using phage display method. International-journal Peer-reviewed

Juichi Fujimori, Ichiro Nakashima, Kazuo Fujihara, Tatsuro Misu, Shigeru Sato, Yasuto Itoyama

Multiple sclerosis international　2011　353417-353417　2011

DOI： 10.1155/2011/353417 　

ISSN： 2090-2654

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To investigate the antigen recognized by cerebrospinal fluid (CSF) high affinity IgG in patients with multiple sclerosis (MS), the phage display method was applied to the CSF from 15 MS and 10 control patients. Peptide sequences recognized by MS and control CSF IgG were individual specific, and no common motif was found. Peptide sequences frequently showed homology to various kinds of amino acid sequences of ubiquitous viruses such as epstein barr virus (EBV) and herpes simplex virus (HSV), although the frequency was not specific to MS patients. MS CSF IgG may recognize various types of ubiquitous viral antigen and may be increased by a bystander response.
CSF proteomic pattern analysis of multiple sclerosis and its related disorders Peer-reviewed

Komori Mika, Matsuyama Yumiko, Nirasawa Takashi, Thiele Herbert, Becker Michael, Alexandrov Theodore, Tanaka Masami, Saida Takahiko, Misu Tatsuro, Fujihara Kazuo, Tomimoto Hidekazu, Ito Hidefumi, Takahashi Ryosuke, Tashiro Kei, Ikegawa Masaya, Kondo Takayuki

JOURNAL OF NEUROIMMUNOLOGY　228　(1-2)　49-49　2010/11

ISSN： 0165-5728
Characteristic brain magnetic resonance imaging abnormalities in central nervous system aquaporin-4 autoimmunity Peer-reviewed

Woojun Kim, Min Su Park, Sang Hyun Lee, Su-Hyun Kim, In Ja Jung, Toshiyuki Takahashi, Tatsuro Misu, Kazuo Fujihara, Ho Jin Kim

MULTIPLE SCLEROSIS JOURNAL　16　(10)　1229-1236　2010/10

DOI： 10.1177/1352458510376640 　

ISSN： 1352-4585
Inflammation induced by innate immunity in the central nervous system leads to primary astrocyte dysfunction followed by demyelination Peer-reviewed

Rakhi Sharma, Marie-Therese Fischer, Jan Bauer, Paul A. Felts, Kenneth J. Smith, Tatsuro Misu, Kazuo Fujihara, Monika Bradl, Hans Lassmann

ACTA NEUROPATHOLOGICA　120　(2)　223-236　2010/08

DOI： 10.1007/s00401-010-0704-z 　

ISSN： 0001-6322
多発性硬化症と視神経脊髄炎における髄液ミエリン塩基性蛋白(MBP) Peer-reviewed

清水優子, 藤原一男, 久保幸子, 三須建郎, 富澤雄二, 横山和正, 高橋利幸, 服部信孝, 糸山泰人, 内山真一郎

医学と薬学　64　(2)　281-286　2010/08
Publisher:
ISSN： 0389-3898
Neuromyelitis optica preceded by hyperCKemia episode. Peer-reviewed

Suzuki N, Takahashi T, Aoki M, Misu T, Konohana S, Okumura T, Takahashi H, Kameya S, Yamaki K, Kumagai T, Fujihara K, Itoyama Y

Neurology　74　(19)　1543-1545　2010/05

DOI： 10.1212/WNL.0b013e3181dd445b 　
Effects of Aquaporin4 Antibody in Primary Human Astrocytes in Culture: A Living Cell Imaging Analysis Peer-reviewed

Nishiyama Shuhei, Misu Tatsuro, Takano Rina, Takahashi Toshiyuki, Nakashima Ichiro, Fujihara Kazuo, Itoyama Yasuto

NEUROLOGY　74　(9)　A165　2010/03/02

ISSN： 0028-3878
Painful Tonic Spasm in Neuromyelitis Optica Peer-reviewed

Yoshiki Takai, Ichiro Nakashima, Tatsuro Misu, Kazuo Fujihara, Yasuto Itoyama

NEUROLOGY　74　(9)　A168-A169　2010/03

ISSN： 0028-3878
Dorsal-roots enhancement and Wallerian degeneration of dorsal cord in the patient of acute sensory ataxic neuropathy. International-journal Peer-reviewed

Kaoru Endo, Naoki Suzuki, Tatsuro Misu, Masashi Aoki, Yasuto Itoyama

Journal of neurology　256　(10)　1765-6　2009/10

DOI： 10.1007/s00415-009-5186-3 　

ISSN： 0340-5354
Occurrence of acute large and edematous callosal lesions in neuromyelitis optica Peer-reviewed

M. Nakamura, T. Misu, K. Fujihara, I. Miyazawa, I. Nakashima, T. Takahashi, S. Watanabe, Y. Itoyama

MULTIPLE SCLEROSIS　15　(6)　695-700　2009/06

DOI： 10.1177/1352458509103301 　

ISSN： 1352-4585
CCR7+myeloid dendritic cells together with CCR7+T cells and CCR7+macrophages invade CCL19+nonnecrotic muscle fibers in inclusion body myositis Peer-reviewed

Maki Tateyama, Kazuo Fujihara, Tatsuro Misu, Yasuto Itoyama

JOURNAL OF THE NEUROLOGICAL SCIENCES　279　(1-2)　47-52　2009/04

DOI： 10.1016/j.jns.2008.12.024 　

ISSN： 0022-510X
Plasma Exchange for Neuromyelitis Optica with Anti-Aquaporin-4 Antibody Peer-reviewed

Nakashima Ichiro, Takahashi Toshiyuki, Nishiyama Shuhei, Kasahara Sayuko, Suzuki Chihiro, Misu Tatsuro, Itoyama Yasuto, Fujihara Kazuo

NEUROLOGY　72　(11)　A187　2009/03/17

ISSN： 0028-3878
Narcolepsy as an initial manifestation of neuromyelitis optica with antiaquaporin-4 antibody Peer-reviewed

Toru Baba, Ichiro Nakashima, Takashi Kanbayashi, Masatoshi Konno, Toshiyuki Takahashi, Kazuo Fujihara, Tatsuro Misu, Atsushi Takeda, Yusei Shiga, Hiromasa Ogawa, Yasuto Itoyama

JOURNAL OF NEUROLOGY　256　(2)　287-288　2009/02

DOI： 10.1007/s00415-009-0139-4 　

ISSN： 0340-5354
PROCALCITONIN MIGHT HELP IN DISCRIMINATION BETWEEN MENINGEAL NEURO-BEHCET DISEASE AND BACTERIAL MENINGITIS Peer-reviewed

N. Suzuki, H. Mizuno, M. Nezu, Y. Takai, T. Misu, H. Kuroda, M. Aoki, I. Nakashima, Y. Itoyama

NEUROLOGY　72　(8)　762-763　2009/02

DOI： 10.1212/01.wnl.0000343046.88848.76 　

ISSN： 0028-3878
Pathology of neuromyelitis optica Peer-reviewed

Tatsuro Misu

Clinical Neurology　49　(11)　896-899　2009

DOI： 10.5692/clinicalneurol.49.896 　

ISSN： 0009-918X
Intractable hiccup and nausea in neuromyelitis optica with anti-aquaporin-4 antibody: a herald of acute exacerbations Peer-reviewed

T. Takahashi, I. Miyazawa, T. Misu, R. Takano, I. Nakashima, K. Fujihara, M. Tobita, Y. Itoyama

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY　79　(9)　1075-1078　2008/09

DOI： 10.1136/jnnp.2008.145391 　

ISSN： 0022-3050
A prominent elevation of glial fibrillary acidic protein in the cerebrospinal fluid during relapse in neuromyelitis optica Peer-reviewed

Rina Takano, Tatsuro Misu, Toshiyuki Takahashi, Masahiro Izumiyama, Kazuo Fujihara, Yasuto Itoyama

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　215　(1)　55-59　2008/05

DOI： 10.1620/tjem.215.55 　

ISSN： 0040-8727

eISSN： 1349-3329
Development of extensive brain lesions following interferon beta therapy in relapsing neuromyelitis optica and longitudinally extensive myelitis Peer-reviewed

Yuko Shimizu, Kazumasa Yokoyama, Tatsuro Misu, Toshiyuki Takahashi, Kazuo Fujihara, Seiji Kikuchi, Yasuto Itoyama, Makoto Iwata

JOURNAL OF NEUROLOGY　255　(2)　305-307　2008/02

DOI： 10.1007/s00415-007-0730-5 　

ISSN： 0340-5354
Preferential spinal central gray matter involvement in neuromyelitis optica - An MRI study Peer-reviewed

M. Nakamura, I. Miyazawa, K. Fujihara, I. Nakashima, T. Misu, S. Watanabe, T. Takahashi, Y. Itoyama

JOURNAL OF NEUROLOGY　255　(2)　163-170　2008/02

DOI： 10.1007/s00415-008-0545-z 　

ISSN： 0340-5354

eISSN： 1432-1459
Development of extensive brain lesions following interferon beta therapy in relapsing neuromyelitis optica and longitudinally extensive myelitis Peer-reviewed

Yuko Shimizu, Kazumasa Yokoyama, Tatsuro Misu, Toshiyuki Takahashi, Kazuo Fujihara, Seiji Kikuchi, Yasuto Itoyama, Makoto Iwata

JOURNAL OF NEUROLOGY　255　(2)　305-307　2008/02

DOI： 10.1007/s00415-007-0730-5 　

ISSN： 0340-5354
Modulation of dendritic cell development by immunoglobulin G in control subjects and multiple sclerosis patients Peer-reviewed

K. Ohkuma, T. Sasaki, S. Kamei, S. Okuda, H. Nakano, T. Hamamoto, K. Fujihara, I. Nakashima, T. Misu, Y. Itoyama

CLINICAL AND EXPERIMENTAL IMMUNOLOGY　150　(3)　397-406　2007/12

DOI： 10.1111/j.1365-2249.2007.03496.x 　

ISSN： 0009-9104
Successful treatment of a hypothalamic lesion in neuromyelitis optica by plasma exchange Peer-reviewed

Shohei Watanabe, Ichiro Nakashima, Isabelle Miyazawa, Tatsuro Misu, Yusei Shiga, Yoichi Nakagawa, Kazuo Fujihara, Yasuto Itoyama

JOURNAL OF NEUROLOGY　254　(5)　670-671　2007/05

DOI： 10.1007/s00415-006-0329-2 　

ISSN： 0340-5354
Loss of aquaporin-4 in active perivascular lesions in neuromyelitis optica Peer-reviewed

Misu Tatsuro, Fujihara Kazuo, Kakita Akiyoshi, Konno Hidehiko, Nakamura Masashi, Watanabe Shohei, Takahashi Toshiaki, Nakashima Ichiro, Takahashi Hitoshi, Itoyama Yasuto

NEUROLOGY　68　(12)　A196　2007/03/20

ISSN： 0028-3878
Therapeutic efficacy of plasma exchange in NMO-IgG-positive patients with neuromyelitis optica Peer-reviewed

S. Watanabe, I. Nakashima, T. Misu, I. Miyazawo, Y. Shiga, K. Fujihara, Y. Itoyama

MULTIPLE SCLEROSIS　13　(1)　128-132　2007/01

DOI： 10.1177/1352458506071174 　

ISSN： 1352-4585
Muscle cramp-fasciculation syndromeで発症した運動ニューロン疾患の2例 Peer-reviewed

竪山真規, 三須建郎, 小野寺好明, 志賀裕正, 糸山泰人

末梢神経　17　(2)　206-208　2006/12
Publisher:
ISSN： 0917-6772
Expression of CCR7 and its ligands CCL19/CCL21 in muscles of polymyositis Peer-reviewed

Maki Tateyama, Kazuo Fujihara, Tatsuro Misu, Juan Feng, Yoshiaki Onodera, Yasuto Itoyama

Journal of the Neurological Sciences　249　(2)　158-165　2006/11/15

DOI： 10.1016/j.jns.2006.06.021 　

ISSN： 0022-510X
Expression of CCR7 and its ligands CCL19/CCL21 in muscles of polymyositis Peer-reviewed

Maki Tateyama, Kazuo Fujihara, Tatsuro Misu, Juan Feng, Yoshiaki Onodera, Yasuto Itoyama

JOURNAL OF THE NEUROLOGICAL SCIENCES　249　(2)　158-165　2006/11

DOI： 10.1016/j.jns.2006.06.021 　

ISSN： 0022-510X
Clinical and MRI features of Japanese patients with multiple sclerosis positive for NMO-IgG Peer-reviewed

I. Nakashima, K. Fujihara, I. Miyazawa, T. Misu, K. Narikawa, M. Nakamura, S. Watanabe, T. Takahashi, S. Nishiyama, Y. Shiga, S. Sato, B. G. Weinshenker, Y. Itoyama

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY　77　(9)　1073-1075　2006/09

DOI： 10.1136/jnnp.2005.080390 　

ISSN： 0022-3050
Relevance of callosal and periventricular MRI lesions to oligoclonal bands in multiple sclerosis Peer-reviewed

Nakashima, I, K Fujihara, H Miyazawa, T Misu, J Fujimori, S Sato, Y Itoyama

ACTA NEUROLOGICA SCANDINAVICA　113　(2)　125-131　2006/02

DOI： 10.1111/j.1600-0404.2005.00552.x 　

ISSN： 0001-6314
Soluble CD26 and CD30 levels in CSF and sera of patients with relapsing neuromyelitis optica Peer-reviewed

K Narikawa, T Misu, K Fujihara, Nakashima, I, S Sato, Y Itoyama

JOURNAL OF NEUROLOGY　253　(1)　111-113　2006/01

DOI： 10.1007/s00415-005-0901-1 　

ISSN： 0340-5354
Relapsing focal myositis - The localization detected by gallium citrate Ga 67 scintigraphy Peer-reviewed

T Misu, M Tateyama, Nakashima, I, Y Shiga, K Fujihara, Y Itoyama

ARCHIVES OF NEUROLOGY　62　(12)　1930-1931　2005/12

DOI： 10.1001/archneur.62.12.1930 　

ISSN： 0003-9942
CSF-chemokines in HTLV-I-associated myelopathy: CXCL10 up-regulation and therapeutic effect of interferon-alpha Peer-reviewed

K Narikawa, K Fujihara, T Misu, J Feng, J Fujimori, Nakashima, I, Miyazawa, I, H Saito, S Sato, Y Itoyama

JOURNAL OF NEUROIMMUNOLOGY　159　(1-2)　177-182　2005/02

DOI： 10.1016/j.jneuroim.2004.10.011 　

ISSN： 0165-5728
Chemokine profile in the cerebrospinal fluid and serum of Vogt-Koyanagi-Harada disease Peer-reviewed

Miyazawa, I, T Abe, K Narikawa, J Feng, T Misu, Nakashima, I, J Fujimori, M Tamai, K Fujihara, Y Itoyama

JOURNAL OF NEUROIMMUNOLOGY　158　(1-2)　240-244　2005/01

DOI： 10.1016/j.jneuroim.2004.07.014 　

ISSN： 0165-5728
Th1/Th2 balance and HTLV-I proviral load in HAM/TSP patients treated with interferon-alpha Peer-reviewed

J Feng, T Misu, K Fujihara, N Misawa, Y Koyanagi, Y Shiga, A Takeda, S Sato, S Takase, T Kohnosu, H Saito, Y Itoyama

JOURNAL OF NEUROIMMUNOLOGY　151　(1-2)　189-194　2004/06

DOI： 10.1016/j.neuroim.2004.02.007 　

ISSN： 0165-5728
CSF chemokine levels in relapsing neuromyelitis optica and multiple sclerosis Peer-reviewed

K Narikawa, T Misu, K Fujihara, Nakashima, I, S Sato, Y Itoyama

JOURNAL OF NEUROIMMUNOLOGY　149　(1-2)　182-186　2004/04

DOI： 10.1016/j.jneuroim.2003.12.010 　

ISSN： 0165-5728
Absence of IgG1 response in the cerebrospinal fluid of relapsing neuromyelitis optica Peer-reviewed

Nakashima, I, K Fujihara, J Fujimori, K Narikawa, T Misu, Y Itoyama

NEUROLOGY　62　(1)　144-146　2004/01

ISSN： 0028-3878
Interferon-alpha significantly reduces cerebrospinal fluid CD4 cell subsets in HAM/TSP. International-journal Peer-reviewed

Juan Feng, Tatsuro Misu, Kazuo Fujihara, Hiroshi Saito, Toshiaki Takahashi, Takeshi Kohnosu, Yusei Shiga, Atsushi Takeda, Shigeru Sato, Sadao Takase, Yasuto Itoyama

Journal of neuroimmunology　141　(1-2)　170-3　2003/08

DOI： 10.1016/S0165-5728(03)00219-4 　

ISSN： 0165-5728

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We, for the first time, analyzed T cell and natural killer (NK) cell subsets in the cerebrospinal fluid (CSF) in nine patients with human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) treated with interferon-alpha (IFN-alpha). The CD4/CD8 ratio in CSF was significantly lower after the therapy, which is mainly attributable to the significant reduction in CD4+ cells, especially CD25+CD4 and CD45RO+CD4 cell subsets. Meanwhile, NK, natural T and NKT cell subsets in the CSF remained unchanged. There was no CSF lymphocyte subset significantly associated with the clinical efficacy of IFN-alpha in this small-scale study, and more patients should be analyzed to ascertain the link.
A comparative study of Japanese multiple sclerosis patients with and without oligoclonal IgG bands Peer-reviewed

Nakashima, I, K Fujihara, T Misu, J Fujimori, S Sato, S Takase, Y Itoyama

MULTIPLE SCLEROSIS　8　(6)　459-462　2002/12

DOI： 10.1191/1352458502ms831oa 　

ISSN： 1352-4585
Significant correlation between IL-10 levels and IgG indices in the cerebrospinal fluid of patients with multiple sclerosis Peer-reviewed

Nakashima, I, K Fujihara, T Misu, N Okita, S Takase, Y Itoyama

JOURNAL OF NEUROIMMUNOLOGY　111　(1-2)　64-67　2000/11

DOI： 10.1016/S0165-5728(00)00389-1 　

ISSN： 0165-5728
A case of Wernicke-Korsakoff syndrome with dramatic improvement in consciousness immediately after intravenous infusion of thiamine Peer-reviewed

Akio Kikuchi, Keiji Chida, Tatsurou Misu, Naoshi Okita, Hiroshi Nomura, Hidehiko Konno, Sadao Takase, Atsushi Takeda, Yasuto Itoyama

Brain and Nerve　52　(1)　59-63　2000

ISSN： 0006-8969
A case of spontaneous intracranial hypotension with a remarkable leakage and collection of CSF Peer-reviewed

Tatsuro Misu, Toshiaki Takahashi, Shigeru Sato, Maki Tateyama, Hiroyuki Kato, Yasuto Itoyama

Clinical Neurology　39　(9)　948-952　1999/09

ISSN： 0009-918X
乳癌をともなったHTLV-1キャリアに発症した辺縁系脳炎の1例 Peer-reviewed

菊池昭夫, 千田圭二, 三須建郎, 沖田直, 高瀬貞夫, 永田哲也, 酒井宏一郎, 糸山泰人

臨床神経学　39　(5)　555-559　1999/05

ISSN： 0009-918X
[A case of limbic encephalitis associated with breast cancer developed in an HTLV-1 carrier] Peer-reviewed

Kikuchi A, Chida K, Misu T, Okita N, Takase S, Nagata T, Sakai K, Itoyama Y

Rinsho Shinkeigaku　39　(5)　555-559　1999/05

ISSN： 0009-918X

Show all ︎Show first 5

Misc. 432

Analysis of CSF complement profile in myelin oligodendrocyte glycoprotein associated disease.

金子仁彦, 黒田宙, 黒田宙, 小野紘彦, 松本勇貴, 松本勇貴, 松本勇貴, 山崎直也, 山本尚輝, 梅澤周, 生田目知尋, 高井良樹, 高橋利幸, 藤盛寿一, 中島一郎, 藤原一男, 藤原一男, 三須建郎, 青木正志

補体　60　(1)　2023

ISSN： 2188-8205
Myelin oligodendrocyte glycoprotein抗体関連疾患の脳波所見の特徴

此松和俊, 此松和俊, 藤盛寿一, 金子仁彦, 神一敬, 三須建郎, 中島一郎, 中里信和, 青木正志

日本神経学会学術大会プログラム・抄録集　64th　2023
High prevalence of headache of cerebral cortical encephalitis in anti-myelin oligodendrocyte glycoprotein antibody

小川諒, 小川諒, 高橋利幸, 高橋利幸, 中村正史, 藤盛寿一, 三須建郎, 中島一郎, 青木正志

日本頭痛学会誌(Web)　49　(2)　2022

ISSN： 2436-1577
Cases of anti-aquaporin4 antibody-positive neuromyelitis optica spectrum disorder treated with eculizumab initiated immediately after acute treatment

金子仁彦, 浪岡靖弘, 大山綾音, 高井良樹, 檜森紀子, 中澤徹, 三須建郎, 青木正志

神経治療学(Web)　39　(4)　2022

ISSN： 2189-7824
【多発性硬化症と視神経脊髄炎update-基礎・臨床研究の最新知見-】脱髄性疾患の基礎update 視神経脊髄炎の疾患概念と分子病理

三須建郎

日本臨床　79　(10)　1476-1482　2021/10
Publisher: (株)日本臨床社
ISSN： 0047-1852
視神経脊髄炎におけるアストロサイトパチーに基づいた新たな病期分類の確立と経時変化の解析

高井良樹, 三須建郎, 鈴木博義, 高橋利幸, 藤原一男, 青木正志

神経免疫学　26　(1)　80-80　2021/10
Publisher: (一社)日本神経免疫学会
ISSN： 0918-936X
自己抗体関連視神経炎の診断と治療戦略

三須建郎

神経免疫学　26　(1)　87-87　2021/10
Publisher: (一社)日本神経免疫学会
ISSN： 0918-936X
抗MOG抗体関連疾患の特徴

三須建郎

神経免疫学　26　(1)　94-94　2021/10
Publisher: (一社)日本神経免疫学会
ISSN： 0918-936X
抗MOG抗体関連疾患における髄液中の抗MOG抗体測定の意義

松本勇貴, 金子仁彦, 三須建郎, 生田目知尋, 高井良樹, 黒田宙, 高橋利幸, 中島一郎, 藤原一男, 青木正志

神経免疫学　26　(1)　132-132　2021/10
Publisher: (一社)日本神経免疫学会
ISSN： 0918-936X
視神経脊髄炎急性期における抗補体療法の有用性

金子仁彦, 浪岡靖弘, 大山綾音, 高井良樹, 三須建郎, 青木正志

神経免疫学　26　(1)　149-149　2021/10
Publisher: (一社)日本神経免疫学会
ISSN： 0918-936X
妊娠初期に急性精神症状で発症した自己免疫性脳炎の一例

保坂龍彦, 安藤大祐, 高橋幹弘, 松本勇貴, 小野紘彦, 高井良樹, 菅野直人, 三須建郎, 青木正志

臨床神経学　61　(7)　507-507　2021/07
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
両側小脳病変を呈し、MELASが疑われた兄妹例

船山由希乃, 原田龍平, 鈴木直輝, 三須建郎, 青木正志

臨床神経学　61　(7)　509-509　2021/07
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
一側上肢に限局する筋力低下を呈した抗GalNAc-GD1a IgG抗体陽性運動ニューロパチーの2例

大友瑞貴, 池田謙輔, 四條友望, 高井良樹, 菅野直人, 割田仁, 三須建郎, 青木正志

臨床神経学　61　(7)　509-509　2021/07
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
【脳神経-もう一度眺めてみよう】機能と障害第II脳神経(視神経)optic nerve

三須建郎

Clinical Neuroscience　39　(5)　545-547　2021/05
Publisher: (株)中外医学社
ISSN： 0289-0585
【中枢神経の自己免疫性・炎症性疾患ハンドブック】(第2章)疾患各論視神経脊髄炎関連疾患(NMOSD)

三須建郎

BRAIN and NERVE: 神経研究の進歩　73　(5)　0475-0482　2021/05
Publisher: (株)医学書院
ISSN： 1881-6096

eISSN： 1344-8129
3種類のCBA法による抗MOG抗体測定の比較検討

高橋利幸, 高橋ゆかり, 三須建郎

医学と薬学　78　(3)　289-292　2021/02
Publisher: (株)自然科学社
ISSN： 0389-3898
【延髄とその周辺】最後野症候群

三須建郎

脳神経内科　94　(1)　157-165　2021/01
Publisher: (有)科学評論社
ISSN： 2434-3285
臨床的に多発性硬化症と診断される抗MOG抗体陽性患者の検討

生田目知尋, 三須建郎, 高橋利幸, 小川諒, 金子仁彦, 高井良樹, 西山修平, 中島一郎, 藤原一男, 青木正志

臨床神経学　60　(Suppl.)　S436-S436　2020/11
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
【神経免疫疾患の新知見】視神経脊髄炎の新知見再発予防治療の最近の進歩

小野紘彦, 三須建郎, 藤原一男

臨床免疫・アレルギー科　74　(4)　352-357　2020/10
Publisher: (有)科学評論社
ISSN： 1881-1930
免疫介在性中枢神経疾患の病態と動物モデルを用いた治療法開発 NMOSDとMOG抗体関連疾患の病理病態と治療

三須建郎

神経治療学　37　(6)　S132-S132　2020/10
Publisher: (一社)日本神経治療学会
ISSN： 0916-8443

eISSN： 2189-7824
MS/NMO治療の最新の動向

三須建郎

神経治療学　37　(6)　S187-S187　2020/10
Publisher: (一社)日本神経治療学会
ISSN： 0916-8443

eISSN： 2189-7824
NMOSDにおける補体の役割

三須建郎

神経免疫学　25　(1)　92-92　2020/10
Publisher: (一社)日本神経免疫学会
ISSN： 0918-936X
中枢病変を伴わない末梢神経障害における抗MOG抗体連続37例での検討

金子仁彦, 佐藤ダグラス, 高橋利幸, 高井良樹, 西山修平, 三須建郎, 中島一郎, 藤原一男, 青木正志

神経免疫学　25　(1)　151-151　2020/10
Publisher: (一社)日本神経免疫学会
ISSN： 0918-936X
臨床的に多発性硬化症と診断される抗MOG抗体陽性患者の検討

生田目知尋, 三須建郎, 高橋利幸, 小川諒, 金子仁彦, 高井良樹, 西山修平, 中島一郎, 藤原一男, 青木正志

神経免疫学　25　(1)　152-152　2020/10
Publisher: (一社)日本神経免疫学会
ISSN： 0918-936X
Endothelial damage in patients with neuromyelitis optica spectrum disorder with aquaporin-4 IgG

Hiroshi Kuroda, Yoshiki Takai, Shuhei Nishiyama, Toshiyuki Takahashi, Tatsuro Misu, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki

MULTIPLE SCLEROSIS JOURNAL　26　(9)　NP77-NP78　2020/08

ISSN： 1352-4585

eISSN： 1477-0970
Elevated cerebrospinal fluid-CRMP5 levels in acute phase of NMOSD with AQP4-IgG and the prognostic implication

Shuhei Nishiyama, Tatsuro Misu, Yoshiki Takai, Toshiyuki Takahashi, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki

MULTIPLE SCLEROSIS JOURNAL　26　(9)　NP77-NP77　2020/08

ISSN： 1352-4585

eISSN： 1477-0970
【脊椎脊髄疾患に対する分類・評価法】(第10章)脊髄変性・炎症多発性硬化症の診断基準

三須建郎

脊椎脊髄ジャーナル　33　(4)　504-508　2020/04
Publisher: (株)三輪書店
ISSN： 0914-4412
MOG抗体関連疾患での血液脳関門破綻メカニズムの解明

清水文崇, 小川諒, 原佳那子, 門野ちひろ, 高橋利幸, 竹下幸男, 三須建郎, 佐野泰照, 前田敏彦, 中島一郎, 藤原一男, 神田隆

Neuroimmunology　25　(1)　2020

ISSN： 0918-936X
頭部外傷を契機に発症した抗MOG抗体関連脳脊髄炎の一例

佐藤一輝, 西山亜由美, 鈴木直輝, 張替宗介, 齋藤早紀, 池田謙輔, 西山修平, 三須建郎, 割田仁, 黒田宙, 青木正志

臨床神経学　59　(11)　760-760　2019/11
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
治療抵抗性の重症抗MOG抗体関連疾患に対するリツキシマブの使用経験

松本勇貴, 三須建郎, 高井良樹, 西山修平, 小野紘彦, 黒田宙, 割田仁, 青木正志, 黒澤和大, 清水洋, 藤原一男

神経治療学　36　(6)　S288-S288　2019/10
Publisher: (一社)日本神経治療学会
ISSN： 0916-8443

eISSN： 2189-7824
自己免疫性脳炎抗MOG抗体陽性患者におけるT細胞反応性に関する検討

小野紘彦, 三須建郎, 高井良樹, 西山修平, 黒田宙, 高橋利幸, 中島一郎, 藤原一男, 青木正志

神経免疫学　24　(1)　96-96　2019/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
MS/NMO 2 視神経脊髄炎中枢組織障害に対するIL-6の影響に関する病理学的検討

高井良樹, 三須建郎, 松本勇貴, 生田目知尋, 小野紘彦, 西山修平, 黒田宙, 藤原一男, 青木正志

神経免疫学　24　(1)　118-118　2019/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
抗MOG抗体関連疾患急性期治療後の経時的障害度と予後の検討

生田目知尋, 三須建郎, 西山修平, 高井良樹, 小野紘彦, 松本勇貴, 高橋利幸, 中島一郎, 藤原一男, 青木正志

神経免疫学　24　(1)　153-153　2019/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
急性脳炎・脳炎 NMDA型およびAMPA型抗グルタミン酸受容体抗体陽性脳炎における臨床・画像・病理の比較検討

金子仁彦, 三須建郎, 黒田宙, 加藤量広, 板倉裕子, 鈴木靖士, 鈴木博義, 藤盛寿一, 中島一郎, 藤原一男

神経免疫学　24　(1)　109-109　2019/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
臨床ケース神経ベーチェット病に類似した症候を呈した抗MOG抗体陽性脳炎の2例

藤盛寿一, 高橋利幸, 松本勇貴, 藤原一男, 高井良樹, 三須建郎, 中島一郎

神経免疫学　24　(1)　114-114　2019/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
髄膜脳炎にて発症し、生検し得た抗myelin oligodendrocyte glycoprotein(MOG)抗体関連疾患の1例

成毛哲思, 岩中行己男, 橋本智代, 岡田和将, 金子仁彦, 三須建郎, 足立弘明

臨床神経学　59　(8)　555-555　2019/08
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
肺癌術後に発症し、治療に難渋した傍腫瘍性NMOSDの1例

松原史歩, 西山修平, 中屋亮彦, 小野理佐子, 西山亜由美, 三須建郎, 割田仁, 黒田宙, 青木正志

臨床神経学　59　(7)　477-477　2019/07
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
骨髄異形成症候群の経過中に抗MOG抗体関連脳脊髄炎を発症した67歳女性

臼田真帆, 渡部理恵, 星研一, 石井亘, 羽生憲直, 矢彦沢裕之, 高橋利幸, 三須建郎, 佐藤俊一

臨床神経学　59　(5)　295-295　2019/05
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
The relevance of cerebrospinal fluid polymorphonuclear leukocytes in diagnosis of inflammatory CNS diseases

Hiroshi Kuroda, Kimihiko Kaneko, Ryo Ogawa, Yoshiki Takai, Shuhei Nishiyama, Toshiyuki Takahashi, Tatsuro Misu, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki

MULTIPLE SCLEROSIS JOURNAL　25　(3)　479-479　2019/03

ISSN： 1352-4585

eISSN： 1477-0970
Neuromyelitis optica spectrum and myelin oligodendrocyte glycoprotein antibody-related disseminated encephalomyelitis

Tatsuro Misu, Kazuo Fujihara

Clinical and Experimental Neuroimmunology　10　(1)　9-17　2019/02/01
Publisher: Wiley-Blackwell
DOI： 10.1111/cen3.12491 　

ISSN： 1759-1961
【炎症性脱髄性疾患update-臨床・病理から画像診断まで-】炎症性脱髄性疾患の臨床

三須建郎

画像診断　39　(3)　256-262　2019/02
Publisher: (株)学研メディカル秀潤社
ISSN： 0285-0524

eISSN： 2432-1281
【炎症性脱髄性疾患update-臨床・病理から画像診断まで-】炎症性脱髄性疾患の病理

三須建郎

画像診断　39　(3)　263-271　2019/02
Publisher: (株)学研メディカル秀潤社
ISSN： 0285-0524

eISSN： 2432-1281
The pathological features of MOG antibody-positive cerebral cortical encephalitis as a new spectrum associated with MOG antibodies

Toshimasa Ikeda, Kentaro Yamada, Tatsuro Misu, Ryo Ogawa, Yoshiki Takai, Maya Mimuro, Yasushi Iwasaki, Kaoru Kamimoto, Noriyuki Matsukawa, Mari Yoshida

BRAIN PATHOLOGY　29　15-15　2019/02

ISSN： 1015-6305

eISSN： 1750-3639
Perivenous inflammatory demyelination is the prominent pathology in myelin oligodendrocyte glycoprotein antibody-associated disease

Yoshiki Takai, Misu Tatsuro, Kaneko Kimihiko, Norio Chihara, Kouidhi Narikawa, Satoko Tsuchida, Hiroya Nishida, Takahashi Toshiyuki, Masashi Aoki, Fujihara Kazuo

BRAIN PATHOLOGY　29　13-13　2019/02

ISSN： 1015-6305

eISSN： 1750-3639
【視神経脊髄炎スペクトル障害(NMO-SD)】NMO-SDの疾患概念

三須建郎, 藤原一男

脳神経内科　90　(1)　1-6　2019/01
Publisher: (有)科学評論社
ISSN： 2434-3285
【視神経脊髄炎スペクトル障害(NMO-SD)】NMO-SDのMRI画像所見

小野紘彦, 三須建郎

脳神経内科　90　(1)　85-89　2019/01
Publisher: (有)科学評論社
ISSN： 2434-3285
【Glymphatic system-脳のゴミ処理とその異常】Glymphatic systemにおけるアクアポリンの役割 NMOとglymphatic system

三須建郎

Clinical Neuroscience　37　(1)　49-51　2019/01
Publisher: (株)中外医学社
ISSN： 0289-0585
診断に難渋した抗MOG抗体関連疾患の64歳女性例

門倉彩奈, 湯谷佐知子, 川村玲衣奈, 安田高志, 永田栄一郎, 瀧澤俊也, 高橋利幸, 三須建郎

臨床神経学　58　(12)　777-777　2018/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
【中枢神経系脱髄疾患の最前線-抗MOG抗体の関与を考える】抗MOG抗体関連疾患抗MOG抗体関連脳脊髄炎の病理学的特徴

三須建郎

Clinical Neuroscience　36　(11)　1330-1333　2018/11
Publisher: (株)中外医学社
ISSN： 0289-0585
抗MOG抗体関連疾患に対する血漿交換療法add-onの有効性に関する検討

生田目知尋, 西山修平, 三須建郎, 高井良樹, 黒田宙, 中島一郎, 藤原一男, 青木正志

神経治療学　35　(6)　S220-S220　2018/11
Publisher: (一社)日本神経治療学会
ISSN： 0916-8443

eISSN： 2189-7824
再発寛解型多発性硬化症に対してNatalizumabを使用した11例の検討

西山修平, 三須建郎, 高井良樹, 黒田宙, 中島一郎, 藤原一男, 青木正志

神経治療学　35　(6)　S221-S221　2018/11
Publisher: (一社)日本神経治療学会
ISSN： 0916-8443

eISSN： 2189-7824
異なる経過をたどり抗MOG抗体陽性であった中枢神経単純ヘルペス感染症の2例

金子仁彦, 佐藤ダグラス, 高橋利幸, 小川諒, 高井良樹, 西山修平, 三須建郎, 黒田宙, 佐藤亮介, 小林修, 田中覚, 田島孝士, 中島一郎, 藤原一男, 青木正志

NEUROINFECTION　23　(2)　221-221　2018/10
Publisher: 日本神経感染症学会
ISSN： 1348-2718

eISSN： 2435-2225
急性脳炎・脳症異なる臨床経過を呈した抗AMPA受容体抗体辺縁系脳炎3例の検討

中村尚子, 金子仁彦, 曽我天馬, 池之内初, 加藤量広, 渡辺源也, 突田健一, 西山修平, 三須達郎, 成川孝一

神経免疫学　23　(1)　96-96　2018/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
分子神経病理学の最新知見 MOG-related disseminated encephalomyelitisの臨床病理学的特徴

三須建郎

神経免疫学　23　(1)　52-52　2018/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
急性脳炎・脳症中枢神経系の単純ヘルペス感染の関与が疑われた抗MOG抗体陽性神経疾患の2例

金子仁彦, 佐藤ダグラス, 高橋利幸, 小川諒, 高井良樹, 西山修平, 三須建郎, 黒田宙, 佐藤亮介, 小林修

神経免疫学　23　(1)　95-95　2018/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
再発寛解型多発性硬化症に対するNatalizumabの使用経験11例での検討

西山修平, 三須建郎, 高井良樹, 黒田宙, 中島一郎, 藤原一男, 青木正志

神経免疫学　23　(1)　114-114　2018/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
抗MOG抗体陽性皮質脳炎の臨床病理像

池田知雅, 山田健太郎, 小川諒, 高井良樹, 金子仁彦, 三須建郎, 紙本薫, 松川則之, 吉田眞理

神経免疫学　23　(1)　116-116　2018/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
炎症性中枢神経疾患における髄液多形核白血球増多例の検討

黒田宙, 金子公彦, 小川諒, 高井良樹, 西山修平, 三須建郎, 中島一郎, 藤原一男, 青木正志

神経免疫学　23　(1)　126-126　2018/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
抗MOG抗体関連疾患に対する血漿交換療法add-onの有効性に関する検討

生田目知尋, 西山修平, 三須建郎, 高井良樹, 黒田宙, 中島一郎, 藤原一男, 青木正志

神経免疫学　23　(1)　131-131　2018/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
下位脳神経障害を伴った神経痛性筋萎縮症の1例

生田目知尋, 西山亜由美, 菅野直人, 黒田宙, 三須建郎, 青木正志

臨床神経学　58　(8)　536-536　2018/08
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
性格変化で発症した抗myelin oligodendrocyte glycoprotein抗体関連疾患の1例

伊藤萌, 大山宜孝, 冨樫勇人, 雪澤緑, 及川愛里, 岩本眞理, 蒲ひかり, 藤原祐, 渡辺好宏, 武下草生子, 金子仁彦, 高橋利幸, 三須建郎

小児科臨床　71　(6)　1064-1070　2018/06
Publisher: (株)日本小児医事出版社
ISSN： 0021-518X
Discrimination of Spinal Cord Sarcoidosis from Neuromyelitis Optica Spectrum Disorer or Spondylotic Myelopathy

Hiroshi Kuroda, Toshiyuki Takahashi, Douglas Kazutoshi Sato, Ryo Ogawa, Kimihiko Kaneko, Yoshiki Takai, Shuhei Nishiyama, Tatsuro Misu, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki

MULTIPLE SCLEROSIS JOURNAL　24　(3)　380-380　2018/03

ISSN： 1352-4585

eISSN： 1477-0970
Cerebrospilnal Fluid-Actin Related Protein 2/3 Complex Subunit 4 as an Astrocytic Foot Process Damage Marker of Aquaporin-4-Igg Positive Neuromyelitis Optica Spectrum Disorders

Shuhei Nishiyama, Tatsuro Misu, Ichiro Nakashima, Douglas Kazutoshi Sato, Kimihiko Kaneko, Ryo Ogawa, Hirohiko Ono, Kazuhiro Kurosawa, Yoshiki Takai, Toshiyuki Takahashi, Hiroshi Kuroda, Kazuo Fujihara, Masashi Aoki

MULTIPLE SCLEROSIS JOURNAL　24　(3)　380-380　2018/03

ISSN： 1352-4585

eISSN： 1477-0970
Fingolimod-Associated PML with Mild Immune Reconstitution Inflammatory Syndrome in Multiple Sclerosis

Shuhei Nishiyama, Tatsuro Misu, Yukiko Shishido-Hara, Kazuo Nakamichi, Masayuki Saijo, Yoshiki Takai, Kentarou Takei, Naoki Yamamoto, Hiroshi Kuroda, Ryuta Saito, Mika Watanabe, Teiji Tominaga, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki

MULTIPLE SCLEROSIS JOURNAL　24　(3)　381-382　2018/03

ISSN： 1352-4585

eISSN： 1477-0970
抗MOG抗体陽性の疾患群 MOG抗体関連疾患の病理学的特徴

三須建郎

Japanese Journal of Diagnostic Imaging　36　(1)　44-44　2018/02
Publisher: 日本画像医学会
ISSN： 2187-266X
【頸髄症のUp-to-date】 (Part1)症候学と診断多発性硬化症と視神経脊髄炎診断と治療の進歩

三須建郎

Bone Joint Nerve　8　(1)　35-41　2018/01
Publisher: (株)アークメディア
ISSN： 2186-1110
視神経脊髄炎関連疾患に対する経口ステロイド維持療法の最適化

高井良樹, 中島一郎, 三須建郎, 黒田宙, 西山修平, 高橋利幸, 藤原一男, 青木正志

神経治療学　34　(6)　S221-S221　2017/11
Publisher: (一社)日本神経治療学会
ISSN： 0916-8443

eISSN： 2189-7824
視神経脊髄炎関連疾患に対する経口ステロイド維持療法の最適化

高井良樹, 中島一郎, 三須建郎, 黒田宙, 西山修平, 高橋利幸, 藤原一男, 青木正志

神経治療学　34　(6)　S221-S221　2017/11
Publisher: 日本神経治療学会
ISSN： 0916-8443
Clinical, MRI and laboratory features of myelin oligodendrocyte glycoprotein (MOG)-antibody-associated neurologic disease: a study of 259 cases

K. Kaneko, D. K. Sato, T. Takahashi, R. Ogawa, T. Akaishi, Y. Takai, S. Nishiyama, T. Misu, H. Kuroda, I. Nakashima, K. Fujihara, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　23　100-100　2017/10

ISSN： 1352-4585

eISSN： 1477-0970
Cerebrospilnal fluid-Actin related protein 2/3 complex subunit 4 as an astrocytic foot process damage marker of aquaporin-4-IgG positive neuromyelitis optica spectrum disorders

S. Nishiyama, T. Misu, I. Nakashima, D. K. Sato, K. Kaneko, R. Ogawa, Y. Takai, T. Toshiyuki, H. Kuroda, K. Fujihara, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　23　585-585　2017/10

ISSN： 1352-4585

eISSN： 1477-0970
The staging of astrocytopathy in neuromyelitis optica spectrum disorders with aquaporin4-IgG

Y. Takai, T. Misu, H. Suzuki, R. Ogawa, K. Kaneko, S. Nishiyama, H. Kuroda, T. Takahashi, I. Nakashima, K. Fujihara, A. Masashi

MULTIPLE SCLEROSIS JOURNAL　23　27-28　2017/10

ISSN： 1352-4585

eISSN： 1477-0970
Autoimmune encephalitis in patients with anti-myelin oligodendrocyte glycoprotein-antibody

R. Ogawa, I. Nakashima, T. Takahashi, K. Kaneko, T. Akaishi, Y. Takai, D. K. Sato, S. Nishiyama, J. Fujimori, T. Misu, H. Kuroda, T. Ikeda, A. Uchibori, T. Ohashi, K. Fujihara, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　23　439-440　2017/10

ISSN： 1352-4585

eISSN： 1477-0970
抗MOG抗体陽性脱髄疾患の調査報告国内259例の抗MOG抗体陽性例の臨床的特徴

金子仁彦, 佐藤ダグラス, 高橋利幸, 赤石哲也, 小川諒, 高井良樹, 西山修平, 三須建郎, 中島一郎, 藤原一男, 青木正志

神経免疫学　22　(1)　87-87　2017/10
Publisher: 日本神経免疫学会
ISSN： 0918-936X
MS・NMO1 視神経脊髄炎関連疾患病変におけるアストロサイトパチーによる病期分類

高井良樹, 三須建郎, 鈴木博義, 高橋利幸, 西山修平, 黒田宙, 中島一郎, 藤原一男, 青木正志

神経免疫学　22　(1)　97-97　2017/10
Publisher: 日本神経免疫学会
ISSN： 0918-936X
急性脳炎・脳症抗MOG抗体陽性自己免疫性脳炎の検討

小川諒, 中島一郎, 高橋利幸, 金子仁彦, 高井良樹, 藤盛寿一, 三須建郎, 黒田宙, 藤原一男, 青木正志

神経免疫学　22　(1)　104-104　2017/10
Publisher: 日本神経免疫学会
ISSN： 0918-936X
Discrimination of spinal cord sarcoidosis from neuromyelitis optica spectrum disorder or spondylotic myelopathy

H. Kuroda, T. Takahashi, D. Sato, Y. Takai, S. Nishiyama, T. Misu, I. Nakashima, K. Fujihara, M. Aoki

EUROPEAN JOURNAL OF NEUROLOGY　24　113-113　2017/07

ISSN： 1351-5101

eISSN： 1468-1331
多核球優位の細胞増多を呈し、神経ベーチェット病との鑑別を要した悪性リンパ腫の一例

中村貴彬, 高井良樹, 黒田宙, 三須建郎, 青木正志

臨床神経学　57　(6)　353-353　2017/06
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
抗MOG抗体陽性脱髄疾患におけるIFNβの有効性

金子仁彦, 佐藤ダグラス, 小川諒, 赤石哲也, 高井良樹, 西山修平, 高橋利幸, 三須建郎, 黒田宙, 中島一郎, 藤原一男, 青木正志

脳と発達　49　(Suppl.)　S306-S306　2017/05
Publisher: (一社)日本小児神経学会
ISSN： 0029-0831
抗MOG抗体陽性脱髄疾患におけるIFNβの有効性

金子仁彦, 佐藤ダグラス, 小川諒, 赤石哲也, 高井良樹, 西山修平, 高橋利幸, 三須建郎, 黒田宙, 中島一郎, 藤原一男, 青木正志

脳と発達　49　(Suppl.)　S306-S306　2017/05
Publisher: (一社)日本小児神経学会
ISSN： 0029-0831

eISSN： 1884-7668
抗アクアポリン4抗体陽性視神経脊髄炎関連疾患患者の妊娠に関連した再発リスクの検討

清水優子, 藤原一男, 大橋高志, 中島一郎, 横山和正, 池口亮太郎, 高橋利幸, 三須建郎, 清水悟, 青木正志, 北川一夫

東京女子医科大学雑誌　87　(1)　43-44　2017/04/25
Publisher: 東京女子医科大学学会
ISSN： 0040-9022
抗アクアポリン4抗体陽性視神経脊髄炎関連疾患患者の妊娠に関連した再発リスクの検討

清水優子, 藤原一男, 大橋高志, 中島一郎, 横山和正, 池口亮太郎, 高橋利幸, 三須建郎, 清水悟, 青木正志, 北川一夫

東京女子医科大学雑誌　87　(1-2)　43-44　2017/04
Publisher: 東京女子医科大学学会
ISSN： 0040-9022
Cytokine/Chemokine Profile in MOG-Ab plus Disorder

K. Kaneko, D. K. Sato, R. Ogawa, T. Akaishi, Y. Takai, S. Nishiyama, T. Takahashi, T. Misu, H. Kuroda, S. Tanaka, Nakashima, I, K. Nomura, K. Fujihara, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　23　(2)　318-318　2017/02

ISSN： 1352-4585

eISSN： 1477-0970
Hypoxia-like Tissue Injury and Glial Response Contribute to the Development of Balo's Concentric Demyelination

Y. Takai, T. Misu, S. Nishiyama, H. Ono, H. Kuroda, I. Nakashima, R. Saito, M. Kanamori, S. Mugikura, M. Watanabe, M. Aoki, K. Fujihara

MULTIPLE SCLEROSIS JOURNAL　23　(2)　349-350　2017/02

ISSN： 1352-4585

eISSN： 1477-0970
多核球優位の細胞増多を呈し,神経ベーチェット病との鑑別を要した悪性リンパ腫の一例

中村貴彬, 高井良樹, 黒田宙, 三須建郎, 青木正志

臨床神経学(Web)　57　(6)　2017

ISSN： 1882-0654
エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立に関する研究抗MOG抗体陽性例における免疫病態解析

藤原一男, 藤原一男, 金子仁彦, 佐藤ダグラス, 佐藤ダグラス, 小川諒, 赤石哲也, 西山修平, 高井良樹, 三須建郎, 高橋利幸, 高橋利幸, 黒田宙, 中島一郎, 青木正志

エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立平成28年度総括・分担研究報告書(Web)　41‐42 (WEB ONLY)　2017
抗MOG抗体陽性例の髄液サイトカインの解析

金子仁彦, 佐藤ダグラス, 小川諒, 田中覚, 高井良樹, 西山修平, 三須建郎, 高橋利幸, 黒田宙, 中島一郎, 野村恭一, 藤原一男, 青木正志

神経治療学　33　(5)　S252-S252　2016/10
Publisher: 日本神経治療学会
ISSN： 0916-8443

eISSN： 2189-7824
Elevated cerebrospinal fluid-CRMP5 as a biomarker of damage to astrocyte foot process and growth corn in AQP4-IgG-seropositve NMOSD

S. Nishiyama, T. Misu, I. Nakashima, T. Takahashi, K. Fujihara, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　22　579-580　2016/09

ISSN： 1352-4585

eISSN： 1477-0970
Temporal changes of pathological features in NMO spectrum disorders with aquaporin4 antibody

Y. Takai, T. Misu, I. Nakashima, H. Kuroda, T. Takahashi, S. Nishiyama, K. Kaneko, T. Akaishi, R. Ogawa, K. Fujihara, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　22　156-157　2016/09

ISSN： 1352-4585

eISSN： 1477-0970
Pro-inflammatory cytokine elevation in MOG-Ab+, AQP4-Ab+ disorder and MS

K. Kaneko, D. K. Sato, R. Ogawa, T. Akaishi, Y. Takai, S. Nishiyama, T. Takahashi, T. Misu, H. Kuroda, S. Tanaka, I. Nakashima, K. Nomura, D. Callegaro, K. Fujihara, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　22　155-156　2016/09

ISSN： 1352-4585

eISSN： 1477-0970
Adult MOG-IgG-positive, benign, unilateral, cerebral cortical encephalitis with epileptic seizure

R. Ogawa, I. Nakashima, T. Takahashi, H. Ono, K. Kaneko, T. Akaishi, K. Kurosawa, Y. Takai, D. K. Sato, S. Nishiyama, T. Misu, K. Fujihara, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　22　711-711　2016/09

ISSN： 1352-4585

eISSN： 1477-0970
Severely exacerbated neuromyelitis optica rat model with extensive tissue damage including astrocytopathy and axonal damage by high affinity anti-aquaporin-4 monoclonal antibody

K. Kurosawa, T. Misu, Y. Takai, D. K. Sato, T. Takahashi, Y. Abe, H. Iwanari, R. Ogawa, I. Nakashima, K. Fujihara, T. Hamakubo, M. Yasui, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　22　160-161　2016/09

ISSN： 1352-4585

eISSN： 1477-0970
けいれんを伴う成人の抗MOG抗体陽性、良性、片側性、大脳皮質性脳炎

小川諒, 中島一郎, 高橋利幸, 金子仁彦, 高井良樹, 佐藤ダグラス, 三須建郎, 黒田宙, 藤原一男, 青木正志

神経免疫学　21　(1)　106-106　2016/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
Balo病における同心円状脱髄病巣形成に対する虚血性組織障害とグリア細胞の関与

高井良樹, 三須建郎, 西山修平, 黒田宙, 中島一郎, 斎藤竜太, 金森政之, 渡辺みか, 青木正志, 藤原一男

神経免疫学　21　(1)　121-121　2016/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
抗MOG抗体陽性脱髄疾患の多数の急性期髄液におけるサイトカインの解析

金子仁彦, 佐藤ダグラス, 小川諒, 高井良樹, 西山修平, 三須建郎, 高橋利幸, 黒田宙, 中島一郎, 藤原一男, 青木正志

神経免疫学　21　(1)　122-122　2016/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
フィンゴリモド内服中に進行性多巣性白質脳症を発症した多発性硬化症の1例

山本尚輝, 西山修平, 黒田宙, 三須建郎, 中島一郎, 藤原一男, 青木正志

神経免疫学　21　(1)　141-141　2016/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
タクロリムス投与中の水疱性類天疱瘡患者に生じた辺縁系脳炎の1例

佐藤遥太, 塚田全, 水芦政人, 芳賀貴裕, 相場節也, 三須建郎

日本皮膚科学会雑誌　126　(9)　1730-1730　2016/08
Publisher: (公社)日本皮膚科学会
ISSN： 0021-499X

eISSN： 1346-8146
自己抗体の存在が予後良好を示唆する? 抗MOG抗体陽性の炎症性中枢神経疾患の経過

福與なおみ, 萩野谷和裕, 中島一郎, 佐藤ダグラス, 高橋利幸, 三須達郎, 藤原一男, 菊池敦生, 曽木千純, 呉繁夫

日本小児科学会雑誌　120　(2)　335-335　2016/02
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
A Case Of Pulmonary Interstitial Lesions Developed In The Early-Stage Of Neuromyelitis Optica Spectrum Disorder

Y. Asato, T. Kamitani, M. Kuramochi, K. Nakanishi, T. Shimada, T. Misu, T. Takahashi, M. Aoki, K. Fujihara, Y. Kawabata

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　193　2016

ISSN： 1073-449X

eISSN： 1535-4970
エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立に関する研究抗MOG抗体陽性疾患は脱髄が主体の病態である

藤原一男, 藤原一男, 金子仁彦, 佐藤ダグラス, 佐藤ダグラス, 中島一郎, 西山修平, 田中覚, 黒澤和大, 赤石哲也, 黒田宙, 三須建郎, 三須建郎, 野村恭一, 青木正志

エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立に関する研究平成27年度総括・分担研究報告書　76‐77　2016
脊髄炎後の難治性体幹部痛に対し末梢神経刺激療法が有効であった1例

永松謙一, 安藤肇史, 仁村太郎, 三須建郎, 冨永悌二

臨床神経学　55　(12)　955-955　2015/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
階段状の症状増悪をきたした頸肋による胸郭出口症候群の1例

戸恒智子, 澁井彩, 高井良樹, 三須建郎, 黒田宙, 青木正志

臨床神経学　55　(12)　951-951　2015/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
ミトキサントロンが奏効し長期間観察できたMarburg型MSの1例

福留隆泰, 永石彰子, 中根俊成, 松尾秀徳, 浦崎栄一郎, 井関充及, 三須建郎

神経治療学　32　(5)　818-818　2015/09
Publisher: (一社)日本神経治療学会
ISSN： 0916-8443

eISSN： 2189-7824
Depressive state and chronic fatigue in neuromyelitis optica

I. Nakashima, T. Akaishi, T. Misu, K. Fujihara

MULTIPLE SCLEROSIS JOURNAL　21　607-608　2015/09

ISSN： 1352-4585

eISSN： 1477-0970
Cerebrospinal fluid lactic dehydrogenation enzyme levels in acute attacks of inflammatory demyelinating diseases

S. Nishiyama, T. Misu, Y. Takai, R. Takano, T. Takahashi, I. Nakashima, K. Fujihara, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　21　352-352　2015/09

ISSN： 1352-4585

eISSN： 1477-0970
Astrocyte injury and secondary demyelination induced by intracerebral injection of AQP4-IgG and complement in mouse brain

Y. Takai, T. Misu, Y. Abe, K. Kurosawa, T. Takahashi, H. Kuroda, I. Nakashima, S. Nishiyama, D. Sato, M. Yasui, K. Fujihara, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　21　426-426　2015/09

ISSN： 1352-4585

eISSN： 1477-0970
Astrocyte and myelin injury in neuroinflammatory disorders with myelin oligodendrocyte glycoprotein or aquaporin-4 antibody positive cerebrospinal fluid

K. Kaneko, D. K. Sato, I. Nakashima, S. Nishiyama, S. Tanaka, R. Marignier, J. W. Hyun, H. J. Kim, L. M. Oliveira, D. Callegaro, M. Reindl, T. Berger, T. Seifert-Held, A. Saiz, M. Sepulveda, S. Siritho, N. Prayoonwiwat, P. J. Waters, K. Kurosawa, T. Akaishi, H. Kuroda, T. Misu, K. Nomura, K. Fujihara, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　21　134-135　2015/09

ISSN： 1352-4585

eISSN： 1477-0970
Clinical phenotypes of pediatric and adult patients with anti-MOG antibodies

D. K. Sato, K. Kaneko, I. Nakashima, S. Tanaka, N. Fukuyo, L. M. Oliveira, L. Pandit, S. Siritho, P. J. Waters, T. Takahashi, H. Kuroda, S. Nishiyama, T. Akaishi, K. Kurosawa, T. Misu, N. Prayoonwiwat, K. Nomura, D. Callegaro, K. Fujihara, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　21　87-88　2015/09

ISSN： 1352-4585

eISSN： 1477-0970
抗AQP4モノクローナル抗体を用量段階的に投与したpassive IgG transfer NMO rat modelの病理組織学的検討

黒澤和大, 三須建郎, 阿部陽一郎, 高井良樹, 高橋利幸, 佐藤ダグラス, 中島一郎, 藤原一男, 安井正人, 青木正志

神経免疫学　20　(1)　123-123　2015/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
MS基礎 NMOモデルマウスにおけるアストロサイト障害に伴う二次性脱髄機序の解明

高井良樹, 三須建郎, 黒沢和大, 高橋利幸, 中島一郎, 黒田宙, 西山修平, 藤原一男, 青木正志

神経免疫学　20　(1)　96-96　2015/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
インターフェロンβ治療歴はFingolimodの有効性に影響を与えない

山口雄平, 西山修平, 黒田宙, 三須建郎, 中島一郎, 藤原一男, 青木正志

神経治療学　32　(5)　812-812　2015/09
Publisher: 日本神経治療学会
ISSN： 0916-8443

eISSN： 2189-7824
【免疫性神経疾患-基礎・臨床研究の最新知見-】免疫性中枢神経疾患視神経脊髄炎(NMO) 視神経脊髄炎の検査・診断・鑑別診断視神経脊髄炎の画像所見・髄液所見

三須建郎

日本臨床　73　(増刊7 免疫性神経疾患)　277-282　2015/09
Publisher: (株)日本臨床社
ISSN： 0047-1852
High avidity chimeric monoclonal antibodies against the extracellular domains of human aquaporin-4 competing with NMO-IgG

Kaori Miyazaki-Komine, Yoichiro Abe, Ping Huang, Yoshiki Takai, Osamu Arai, Hiroko Iwanari, Tatsuro Misu, Toshiko Sakihama, Yoshiaki Toyama, Kazuo Fujihara, Takao Hamakubo, Masato Yasui

JOURNAL OF PHARMACOLOGICAL SCIENCES　128　(3)　S247-S247　2015/07

ISSN： 1347-8613

eISSN： 1347-8648
【臨床現場での脳・脊髄連関】多発性硬化症,視神経脊髄炎

三須建郎

脊椎脊髄ジャーナル　28　(7)　623-628　2015/07
Publisher: (株)三輪書店
DOI： 10.11477/mf.5002200170 　

ISSN： 0914-4412
抗GAD抗体関連小脳失調症の経過中に1型糖尿病を発症した1例

金子礼, 突田壮平, 白井勇太, 宗像佑一郎, 黒澤聡子, 澤田正二郎, 今井淳太, 三須建郎, 山田哲也, 片桐秀樹

糖尿病　58　(5)　371-371　2015/05
Publisher: (一社)日本糖尿病学会
ISSN： 0021-437X

eISSN： 1881-588X
Cerebrospinal Fluid Aquaporin-4 Antibody Levels in Neuromyelitis Optica Attacks

D. K. Sato, D. Callegaro, F. M. H. Jorge, I. Nakashima, S. Nishiyama, T. Takahashi, R. F. Simm, S. L. Apostolos-Pereira, T. Misu, L. Steinman, M. Aoki, K. Fujihara

MULTIPLE SCLEROSIS JOURNAL　21　(6)　827-827　2015/05

ISSN： 1352-4585

eISSN： 1477-0970
Autoantibodies against MOG in Neuromyelitis Optica Spectrum Disorders

D. K. Sato, D. Callegaro, M. A. Lana-Peixoto, P. J. Waters, S. Tanaka, F. Jorge, T. Takahashi, T. Misu, S. L. Apostolos-Pereira, N. Talim, R. F. Simm, A. M. M. Lino, I. Nakashima, K. Nomura, M. Aoki, K. Fujihara

MULTIPLE SCLEROSIS JOURNAL　21　(6)　804-805　2015/05

ISSN： 1352-4585

eISSN： 1477-0970
Anti-NMDAR plus /anti-MOG plus recurrent ADEM

K. Kaneko, D. K. Sato, T. Misu, K. Kurosawa, I. Nakashima, K. Fujihara, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　21　(6)　836-836　2015/05

ISSN： 1352-4585

eISSN： 1477-0970
The Lesion Localization of Passive Transfer NMO-IgG Model in Lewis Rats

K. Kurosawa, T. Misu, T. Takahashi, D. Sato, S. Nishiyama, H. Kuroda, I. Nakashima, K. Fujihara, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　21　(6)　830-830　2015/05

ISSN： 1352-4585

eISSN： 1477-0970
NMO Immunopathology

Tatsuro Misu

MULTIPLE SCLEROSIS JOURNAL　21　(6)　802-802　2015/05

ISSN： 1352-4585

eISSN： 1477-0970
Clinical characteristics of four patients with temporal lobe epilepsy associated with elevated anti-GAD antibodies

赤石哲也, 赤石哲也, 神一敬, 加藤量広, 加藤量広, 板橋尚, 三須建郎, 竪山真規, 岩崎真樹, 青木正志, 中里信和

臨床神経学(Web)　55　(11)　2015

ISSN： 1882-0654
胸部の帯状絞扼感で発症した神経サルコイドーシスの1例

澁井彩, 小林潤平, 江面道典, 菅野直人, 黒田宙, 三須達郎, 青木正志

臨床神経学　55　(1)　62-62　2015/01
Publisher: (一社)日本神経学会
ISSN： 0009-918X
エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立に関する研究抗MOG抗体陽性症例の臨床,画像及び検査所見の特徴

藤原一男, サトウダグラスカズトシ, 中島一郎, 金子仁彦, 赤石哲也, 黒澤和大, 三須建郎, 高橋利幸, 黒田宙, 西山修平, 青木正志

エビデンスに基づいた神経免疫疾患の早期診断基準・重症度分類・治療アルゴリズムの確立に関する研究平成26年度総括・分担研究報告書　84‐85　2015
[Clinical characteristics of four patients with temporal lobe epilepsy associated with elevated anti-GAD antibodies].

Tetsuya Akaishi, Kazutaka Jin, Kazuhiro Kato, Hisashi Itabashi, Tatsuro Misu, Maki Tateyama, Masaki Iwasaki, Masashi Aoki, Nobukazu Nakasato

Rinsho shinkeigaku = Clinical neurology　55　(11)　804-9　2015
Publisher: (一社)日本神経学会
DOI： 10.5692/clinicalneurol.cn-000740 　

ISSN： 0009-918X
Case of autoantibodies against N-methyl-D-aspartate receptor+/antibodies against myelin-oligodendrocyte glycoprotein+ multiphasic acute disseminated encephalomyelitis (ADEM)

Kimihiko Kaneko, Douglas Kazutoshi Sato, Kazuhiro Kurosawa, Tatsuro Misu, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki

Clinical and Experimental Neuroimmunology　5　(1)　49-51　2014/12/01
Publisher: Wiley-Blackwell
DOI： 10.1111/cen3.12164 　

ISSN： 1759-1961
炎症性脱髄性疾患の診断予後における髄液中GFAP濃度有用性の多施設検討サブ解析結果

西山修平, 三須建郎, 清水優子, 横山和正, 景山卓, 高井良樹, 高野里奈, 高橋利幸, 藤盛寿一, 佐藤滋, 中島一郎, 糸山泰人, 藤原一男, 青木正志

臨床神経学　54　(Suppl.)　S151-S151　2014/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X
多発性硬化症におけるフィンゴリモド投与によるTh17および制御性T細胞の変化

中島一郎, 佐藤ダグラス, 三須建郎, 西山修平, 黒田宙, 青木正志, 藤原一男

臨床神経学　54　(Suppl.)　S57-S57　2014/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
抗アクアポリン4抗体と視神経脊髄炎

三須建郎, 藤原一男

検査と技術　42　(12)　1276-1279　2014/11
Publisher: (株)医学書院
DOI： 10.11477/mf.1543200003 　

ISSN： 0301-2611

eISSN： 1882-1375
【多発性硬化症と視神経脊髄炎】基礎研究の進歩視神経脊髄炎の動物モデル

三須建郎

日本臨床　72　(11)　1941-1948　2014/11
Publisher: (株)日本臨床社
ISSN： 0047-1852
【多発性硬化症のパラダイムシフト-病態から治療まで】診断鑑別診断

黒澤和大, 三須建郎, 佐藤ダグラス

Clinical Neuroscience　32　(11)　1243-1245　2014/11
Publisher: (株)中外医学社
ISSN： 0289-0585
患者血清NMO-IgGを用いたNMOモデルラット作成の試み

黒澤和大, 三須達郎, 高橋利幸, 中島一郎, 藤原一男, 青木正志

神経免疫学　19　(1)　151-151　2014/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
MS vs NMO(疾患を裏側から見る) NMOにおけるmyelinopathy

三須建郎

神経免疫学　19　(1)　70-70　2014/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
グリア細胞からみたMS/NMO

三須建郎

神経免疫学　19　(1)　103-103　2014/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
Marburg型多発性硬化症と診断した一例

福留隆泰, 成田智子, 権藤雄一郎, 永石彰子, 中根俊成, 松尾秀徳, 浦崎栄一郎, 井関充及, 三須建郎

神経免疫学　19　(1)　158-158　2014/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
The lesion localization of passive transfer NMO-IgG model in Lewis rats

K. Kurosawa, T. Misu, Y. Takahashi, D. Sato, S. Nishiyama, H. Kuroda, I. Nakashima, K. Fujihara, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　20　238-239　2014/09

ISSN： 1352-4585

eISSN： 1477-0970
Aquaporin-4 antibody-seropositive myelitis initially biopsied due to suspected spinal cord tumors: diagnostic considerations

T. Misu, D. Sato, C. Rocha, D. Callegaro, I. Nakashima, M. Aoki, K. Fujihara, M. A. Lana-Peixoto

MULTIPLE SCLEROSIS JOURNAL　20　170-170　2014/09

ISSN： 1352-4585

eISSN： 1477-0970
Subanalysis of a multicentric cross-sectional study of CSF-GFAP in the diagnosis of inflammatory demyelinating diseases

S. Nishiyama, T. Misu, Y. Shimizu, K. Yokoyama, T. Kageyama, Y. Takai, R. Takano, T. Takahashi, J. Fujimori, S. Sato, I. Nakashima, K. Fujihara, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　20　187-188　2014/09

ISSN： 1352-4585

eISSN： 1477-0970
Autoantibodies against MOG and aquaporin-4 identify distinct neuromyelitis optica spectrum disorders subgroups

D. K. Sato, D. Callegaro, M. A. Lana-Peixoto, P. J. Waters, S. Tanaka, F. M. H. Jorge, T. Takahashi, T. Misu, S. L. Apostolos-Pereira, N. Talim, R. F. Simm, I. Nakashima, K. Nomura, M. Aoki, K. Fujihara

MULTIPLE SCLEROSIS JOURNAL　20　24-25　2014/09

ISSN： 1352-4585

eISSN： 1477-0970
抗MOG抗体陽性視神経炎の臨床的特徴の解析

赤石哲也, 佐藤ダグラス, 中島一郎, 竹下孝之, 高橋利幸, 三須建郎, 中澤徹, 藤原一男, 青木正志

神経免疫学　19　(1)　112-112　2014/09
Publisher: 日本神経免疫学会
ISSN： 0918-936X
患者血清NMO-IgGを用いたNMOモデルラット作成の試み

黒澤和大, 三須達郎, 高橋利幸, 中島一郎, 藤原一男, 青木正志

NEUROINFECTION　19　(2)　215-215　2014/08
Publisher: 日本神経感染症学会
ISSN： 1348-2718
グリア細胞からみたMS/NMO

三須建郎

NEUROINFECTION　19　(2)　145-145　2014/08
Publisher: 日本神経感染症学会
ISSN： 1348-2718

eISSN： 2435-2225
Marburg型多発性硬化症と診断した一例

福留隆泰, 成田智子, 権藤雄一郎, 永石彰子, 中根俊成, 松尾秀徳, 浦崎栄一郎, 井関充及, 三須建郎

NEUROINFECTION　19　(2)　222-222　2014/08
Publisher: 日本神経感染症学会
ISSN： 1348-2718

eISSN： 2435-2225
自己抗体研究の新たな展開(第10回) 視神経脊髄炎抗アクアポリン4抗体

高井良樹, 三須建郎, 高橋利幸, 中島一郎, 藤原一男

分子リウマチ治療　7　(3)　112-115　2014/07
Publisher: (株)先端医学社
ISSN： 1882-9163
A Multicenter, Cross-Sectional Study of the Usefulness of CSF-GFAP in the Diagnosis and the Prognosis of Inflammatory CNS Diseases

S. Nishiyama, T. Misu, Y. Simizu, K. Yokoyama, T. Kageyama, Y. Takai, R. Takano, T. Takahashi, J. Fujimori, S. Sato, I. Nakashima, Y. Itoyama, K. Fujihara, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　20　(7)　911-911　2014/06

ISSN： 1352-4585

eISSN： 1477-0970
MRI Findings in Optic Neuritis: Neuromyelitis Optica Spectrum Disorder Versus Multiple Sclerosis

K. Kurosawa, T. Misu, S. Nishiyama, D. Sato, H. Kuroda, T. Takahashi, I. Nakashima, K. Fujihara, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　20　(7)　940-940　2014/06

ISSN： 1352-4585

eISSN： 1477-0970
Pathology of Neuromyelitis Optica: The Diversity of Astrocyte Lesions

Tatsuro Misu

MULTIPLE SCLEROSIS JOURNAL　20　(7)　906-906　2014/06

ISSN： 1352-4585

eISSN： 1477-0970
Impact Of The Great East Japan Earthquake In 2011 On MS And NMO: A Study In Sendai, Japan

K. Fujihara, Y. Kanamori, Nakashima, I, Y. Takai, D. K. Sato, T. Misu, S. Sato, J. Fujimori, J. Higuchi, H. Kuroda, Y. Itoyama, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　20　(7)　914-914　2014/06

ISSN： 1352-4585

eISSN： 1477-0970
A Case of Neuromyelitis Optica With Hearing Loss -audiological evidence of therapeutic effect

Y. Takanashi, T. Misu, K. Fujihara, T. Kawase

MULTIPLE SCLEROSIS JOURNAL　20　(7)　951-952　2014/06

ISSN： 1352-4585

eISSN： 1477-0970
The impact of neuromyelitis optica spectrum disorder on pregnancy outcome

M. M. Nour, E. Coutinho, I. Nakashima, F. Sousa, J. Revis, E. Santos, J. George, J. Kitley, T. Misu, M. Woodhall, A. M. Silva, A. Vincent, P. Waters, J. Palace, K. Fujihara, M. I. Leite

EUROPEAN JOURNAL OF NEUROLOGY　21　758-758　2014/05

ISSN： 1351-5101

eISSN： 1468-1331
The impact of neuromyelitis optica spectrum disorder on pregnancy outcome

M. M. Nour, E. Coutinho, I. Nakashima, F. Sousa, J. Revis, E. Santos, J. George, J. Kitley, T. Misu, M. Woodhall, A. M. Silva, A. Vincent, P. Waters, J. Palace, K. Fujihara, M. I. Leite

JOURNAL OF NEUROLOGY　261　S487-S487　2014/05

ISSN： 0340-5354

eISSN： 1432-1459
【脊椎脊髄の科学-基礎と臨床の進歩Review 2014】 (第8章)神経内科疾患多発性硬化症と視神経脊髄炎診断と治療の進歩

三須建郎, 藤原一男

脊椎脊髄ジャーナル　27　(4)　405-410　2014/04
Publisher: (株)三輪書店
ISSN： 0914-4412
検査からみる神経疾患髄液GFAPと視神経脊髄炎(NMO)

高野里菜, 三須建郎, 藤原一男

Clinical Neuroscience　32　(2)　224-226　2014/02
Publisher: (株)中外医学社
ISSN： 0289-0585
免疫性神経疾患に関する調査研究多発性硬化症/視神経脊髄炎臨床抗MOG抗体陽性の中枢神経炎症性脱髄疾患の臨床的特徴の解析

藤原一男, 中島一郎, 佐藤ダグラス, 福與なおみ, 高橋利幸, 三須建郎, 西山修平, 黒田宙, 青木正志

免疫性神経疾患に関する調査研究平成25年度総括・分担研究報告書　13-14　2014
抗GAD抗体陽性側頭葉てんかんの臨床的特徴

赤石哲也, 神一敬, 加藤量広, 板橋尚, 高木正仁, 三須建郎, 竪山真規, 岩崎真樹, 青木正志, 中里信和

臨床神経学　53　(12)　1471-1471　2013/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
炎症性脱髄性疾患の診断・予後における脳脊髄液中GFAP濃度有用性の多施設横断的検討

西山修平, 三須建郎, 清水優子, 横山和正, 景山卓, 高井良樹, 高野里菜, 高橋利幸, 藤盛寿一, 佐藤滋, 中島一郎, 糸山泰人, 藤原一男, 青木正志

臨床神経学　53　(12)　1461-1461　2013/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X
視神経脊髄炎におけるアストロサイトパチー病変とアクアポリン1の関係

三須建郎, 藤原一男, 高井良樹, 西山修平, 中島一郎, 今野秀彦, 糸山泰人, 青木正志

臨床神経学　53　(12)　1530-1530　2013/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
東日本大震災における多発性硬化症および視神経脊髄炎への影響に関するアンケート調査

中島一郎, 金森洋子, 高井良樹, 佐藤滋, 藤盛寿一, 樋口じゅん, 三須建郎, 黒田宙, 藤原一男, 青木正志

臨床神経学　53　(12)　1589-1589　2013/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X
MSの病理(第1回) Prototypic MS

三須建郎

MS Frontier: 多発性硬化症の先端情報誌　2　(2)　62-62　2013/11
Publisher: (株)メディカルレビュー社
ISSN： 2187-3062
炎症性脱髄性疾患の診断・予後における髄液中GFAP濃度有用性の多施設横断的検討

西山修平, 三須建郎, 清水優子, 横山和正, 景山卓, 高橋利幸, 佐藤滋, 中島一郎, 藤原一男, 青木正志

神経免疫学　18　(1)　90-90　2013/11
Publisher: 日本神経免疫学会
ISSN： 0918-936X
抗MOG抗体陽性の視神経脊髄炎スペクトラムの臨床的特徴

佐藤ダグラス, 中島一郎, 高橋利幸, 三須建郎, 黒田宙, 西山修平, 青木正志, 藤原一男

神経免疫学　18　(1)　113-113　2013/11
Publisher: 日本神経免疫学会
ISSN： 0918-936X
脊髄長大病変に髄液多形核白血球増多を伴う疾患群について

黒田宙, 高橋利幸, 佐藤ダグラス, 西山亜由美, 三浦永美子, 西山修平, 三須建郎, 中島一郎, 藤原一男, 青木正志

神経免疫学　18　(1)　113-113　2013/11
Publisher: 日本神経免疫学会
ISSN： 0918-936X
NMO Spectrum Disorderと多発性硬化症における視神経炎のMRI上の特徴

黒澤和大, 三須建郎, 西山修平, 佐藤ダグラス, 黒田宙, 高橋利幸, 中島一郎, 藤原一男, 青木正志

神経免疫学　18　(1)　149-149　2013/11
Publisher: 日本神経免疫学会
ISSN： 0918-936X
MRI findings in optic neuritis of patients with neuromyelitis optica (NMO)-spectrum disorder versus multiple sclerosis

K. Kurosawa, T. Misu, S. Nishiyama, D. Sato, H. Kuroda, T. Takahashi, I. Nakashima, K. Fujihara, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　19　(11)　173-173　2013/10

ISSN： 1352-4585

eISSN： 1477-0970
Diverse mechanisms of tissue injury in neuromyelitis optica

T. Misu, R. Hoeftberger, K. Fujihara, I. Wimmer, Y. Takai, S. Nishiyama, I. Nakashima, H. Konno, M. Bradl, F. Garzuly, Y. Itoyama, M. Aoki, H. Lassmann

MULTIPLE SCLEROSIS JOURNAL　19　(11)　128-128　2013/10

ISSN： 1352-4585

eISSN： 1477-0970
Multiple sclerosis patients in Japan appear to have less disability compared to the UK

G. Kumar, I. Nakashima, Y. Kanamori, T. Misu, Y. Kong, B. Wakerley, S. Ryan, K. Fujihara, J. Palace

MULTIPLE SCLEROSIS JOURNAL　19　(11)　341-341　2013/10

ISSN： 1352-4585

eISSN： 1477-0970
A case series of longitudinally-extended spinal cord lesion with increased polymorphonuclear leukocytes in CSF

H. Kuroda, T. Takahashi, D. Sato, A. Nishiyama, E. Miura, S. Nishiyama, N. Sugeno, T. Misu, I. Nakashima, K. Fujihara, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　19　(11)　316-317　2013/10

ISSN： 1352-4585

eISSN： 1477-0970
【多発性硬化症の新展開】 NMOの臨床と最新研究

三須建郎, 藤原一男

脳21　16　(4)　443-448　2013/10
Publisher: (株)金芳堂
ISSN： 1344-0128
視神経脊髄炎の1剖検例

桂永行, 小泉文人, 紺野加奈子, 山形宗久, 笹生俊一, 深浦彦彰, 三須建郎, 高井良樹

神経治療学　30　(5)　693-693　2013/09
Publisher: (一社)日本神経治療学会
ISSN： 0916-8443

eISSN： 2189-7824
視神経脊髄炎の1剖検例

金子仁彦, 小林理子, 石垣あや, 藤盛寿一, 村上一宏, 三須建郎, 永井真貴子, 今野秀彦, 遠藤実

臨床神経学　53　(9)　755-755　2013/09
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
妊娠中に発症した抗NMDA受容体抗体脳炎の1例

大嶋龍司, 菅野直人, 三須建郎, 中島一郎, 竪山真規, 青木正志

臨床神経学　53　(9)　755-755　2013/09
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
Saffoldウイルスの持続感染と神経病原性の可能性

大原義朗, 姫田敏樹, 大桑孝子, 村木靖, 西山修平, 高橋利幸, 藤盛寿一, 三須建郎, 中島一郎, 藤原一男, 糸山泰人, 青木正志, 石崎義人, 原寿郎, 中村龍文

NEUROINFECTION　18　(2)　153-153　2013/09
Publisher: 日本神経感染症学会
ISSN： 1348-2718
NMO急性期治療としてリツキシマブが有効であった1例

西山修平, 西山亜由美, 三須建郎, 中島一郎, 藤原一男, 青木正志

神経治療学　30　(5)　695-695　2013/09
Publisher: 日本神経治療学会
ISSN： 0916-8443

eISSN： 2189-7824
Diversity in the mechanism of astrocytopathy: Complement dependent and independent attacks against astrocyte foot processes

Tatsuro Misu

Clinical and Experimental Neuroimmunology　4　(2)　165-166　2013/08

DOI： 10.1111/cen3.12050 　

ISSN： 1759-1961
【アストロサイトをめぐる最近の話題】視神経脊髄炎(NMO)におけるアストロサイトの役割

西山修平, 三須建郎, 中島一郎, 藤原一男

神経内科　79　(2)　257-261　2013/08
Publisher: (有)科学評論社
ISSN： 0386-9709
視神経脊髄炎増悪時における髄液中C5a上昇

黒田宙, 高橋利幸, 高野里菜, 三須建郎, 中島一郎, 藤原一男, 青木正志

補体シンポジウム講演集　50　56-57　2013/07
Publisher: (一社)日本補体学会
ISSN： 2185-8470
視神経脊髄炎の免疫病態

三須建郎, 藤原一男

臨床免疫・アレルギー科　60　(1)　104-108　2013/07
Publisher: (有)科学評論社
ISSN： 1881-1930
CIDPを含めた末梢神経病変とALSの合併に関する検討

赤石哲也, 竪山真規, 加藤量広, 三浦永美子, 井泉瑠美子, 遠藤薫, 菅野直人, 鈴木直輝, 馬場徹, 三須建郎, 菊池昭夫, 長谷川隆文, 中島一郎, 青木正志

末梢神経　24　(1)　85-89　2013/06
Publisher: 日本末梢神経学会
ISSN： 0917-6772
【免疫性神経疾患-基礎・臨床研究の最新知見-】視神経脊髄炎(NMO) 視神経脊髄炎の病態メカニズム

三須建郎, 藤原一男

日本臨床　71　(5)　823-828　2013/05
Publisher: (株)日本臨床社
ISSN： 0047-1852
【神経内科検査のみかた-脳のイメージングを中心に】神経内科のトピックス多発性硬化症とNMOの違い

三須建郎, 藤原一男

Modern Physician　33　(5)　663-667　2013/05
Publisher: (株)新興医学出版社
ISSN： 0913-7963
【Antibody Update】 NMO関連疾患と抗AQP4抗体

高井良樹, 三須建郎, 高橋利幸, 中島一郎, 藤原一男

BRAIN and NERVE: 神経研究の進歩　65　(4)　333-343　2013/04
Publisher: (株)医学書院
ISSN： 1881-6096

eISSN： 1344-8129
[Pathogenesis of neuromyelitis optica].

Tatsuro Misu, Kazuo Fujihara

Nihon rinsho. Japanese journal of clinical medicine　71　(5)　823-828　2013

ISSN： 0047-1852
免疫性神経疾患に関する調査研究多発性硬化症/視神経脊髄炎調査東日本大震災における多発性硬化症および視神経脊髄炎への影響についてのアンケート調査

藤原一男, 中島一郎, 金森洋子, 高井良樹, サトウダグラス, 三須建郎, 佐藤滋, 藤盛寿一, 樋口じゅん, 黒田宙

免疫性神経疾患に関する調査研究平成24年度総括・分担研究報告書　2013
Interleukin-1 beta: A driver of the lesion formation in neuromyelitis optica?

Maja Kitic, Sonja Hochmeister, Maria Pohl, Isabella Wimmer, Jan Bauer, Tatsuro Misu, Simone Mader, Markus Reindl, Kazuo Fujihara, Hans Lassmann, Monika Bradl

JOURNAL OF NEUROIMMUNOLOGY　253　(1-2)　143-143　2012/12

ISSN： 0165-5728
NMOにおける非中枢神経系病変

三須建郎, 高井良樹, 高橋利幸, 中島一郎, 糸山泰人, 藤原一男, 青木正志

臨床神経学　52　(12)　1454-1454　2012/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
多発性硬化症におけるインターフェロンβ中和抗体の陽性頻度と臨床的意義の解析

中島一郎, Sato Douglas, 深澤俊行, 清水優子, 富沢雄二, 横山和正, 三須建郎, 藤原一男, 青木正志

臨床神経学　52　(12)　1478-1478　2012/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
ヒトアストロサイト一次培養細胞に対する視神経脊髄炎患者IgG・補体の影響

西山修平, 三須建郎, 高橋利幸, 中島一郎, 糸山泰人, 青木正志, 藤原一男

臨床神経学　52　(12)　1481-1481　2012/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
腫瘍様炎症性脱髄性疾患におけるアストロサイト破壊性病巣

高井良樹, 三須建郎, 小林正樹, 渡邉みか, 中島一郎, 清水優子, 糸山泰人, 藤原一男, 青木正志

臨床神経学　52　(12)　1552-1552　2012/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
末梢血を対象としたMSにおけるSaffoldウイルス感染の解析

大原義朗, 姫田敏樹, 村木靖, 大桑孝子, 西山修平, 高橋利幸, 藤盛寿一, 三須建郎, 中島一郎, 藤原一男, 糸山泰人, 青木正志, 中村龍文

臨床神経学　52　(12)　1608-1608　2012/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X
12年近いCIDP様の末梢神経障害の経過中に球症状を呈し,呼吸不全で死亡した48歳女性

赤石哲也, 加藤量広, 三浦永美子, 井泉瑠美子, 遠藤薫, 菅野直人, 鈴木直輝, 馬場徹, 三須建郎, 菊池昭夫, 長谷川隆文, 黒田宙, 竪山真規, 中島一郎, 青木正志

末梢神経　23　(2)　235-236　2012/12/01
Publisher: 日本末梢神経学会
ISSN： 0917-6772
Neutralising antibodies against interferon-beta and their correlation with clinical and magnetic resonance imaging activity in Japanese multiple sclerosis patients

D. Sato, I. Nakashima, T. Fukazawa, Y. Shimizu, Y. Tomizawa, K. Yokoyama, T. Misu, Y. Itoyama, M. Aoki, K. Fujihara

MULTIPLE SCLEROSIS JOURNAL　18　471-471　2012/10

ISSN： 1352-4585

eISSN： 1477-0970
The effect of NMO-IgG and complement against primary human astrocytes in culture

S. Nishiyama, T. Misu, N. Sugeno, T. Takahashi, I. Nakashima, M. Aoki, K. Fujihara

MULTIPLE SCLEROSIS JOURNAL　18　295-296　2012/10

ISSN： 1352-4585

eISSN： 1477-0970
Saffold virus感染と神経疾患の関係

大原義朗, 姫田敏樹, 大桑孝子, 村木靖, 西山修平, 高橋利幸, 藤盛寿一, 三須建郎, 中島一郎, 藤原一男, 糸山泰人, 青木正志, 石崎義人, 原寿郎, 中村龍文

NEUROINFECTION　17　(2)　224-224　2012/10
Publisher: 日本神経感染症学会
ISSN： 1348-2718
【T細胞を標的とした自己免疫疾患の治療】多発性硬化症治療におけるフィンゴリモド

西山修平, 三須建郎, 中島一郎, 藤原一男

炎症と免疫　20　(6)　562-567　2012/10
Publisher: (株)先端医学社
ISSN： 0918-8371
PATHOLOGICAL FEATURES OF AQUAPORIN-4 AUTOIMMUNITY WITH CYTOTOXIC EDEMA: THE LESSON FROM NEUROMYELITIS OPTICA AND RELATED DISORDERS

T. Misu, Y. Takai, H. Lassmann, I. Nakashima, Y. Itoyama, M. Aoki, K. Fujihara

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH　36　46A-46A　2012/09

ISSN： 0145-6008
NMO ヒトアストロサイト一次培養細胞に対する視神経脊髄炎患者IgG・補体・補体防御因子の影響

西山修平, 三須建郎, 菅野直人, 高橋利幸, 中島一郎, 青木正志, 藤原一男

日本神経免疫学会学術集会抄録集　24回　56-56　2012/09
Publisher: 日本神経免疫学会
NMO急性期治療としてリツキシマブが有効であった1例

西山亜由美, 西山修平, 三須建郎, 中島一郎, 青木正志, 藤原一男

日本神経免疫学会学術集会抄録集　24回　108-108　2012/09
Publisher: 日本神経免疫学会
脊髄円錐・馬尾に病変を認めた抗アクアポリン4抗体陽性視神経脊髄炎の2症例

高井良樹, 三須建郎, 中島一郎, 高橋利幸, 鈴木靖士, 糸山泰人, 藤原一男, 青木正志

日本神経免疫学会学術集会抄録集　24回　127-127　2012/09
Publisher: 日本神経免疫学会
多発性硬化症治療におけるinterferonβ中和抗体の臨床的意義

中島一郎, 佐藤ダグラス, 深澤俊行, 清水優子, 富沢雄二, 横山和正, 三須建郎, 藤原一男, 青木正志

神経治療学　29　(5)　680-680　2012/09
Publisher: 日本神経治療学会
ISSN： 0916-8443

eISSN： 2189-7824
A case of recurrent encephalomyelitis associated with eosinophilia in CSF

Jun Suzuki, Naoto Sugeno, Shuhei Nishiyama, Kimihiko Kaneko, Tatsuro Misu, Maki Tateyama, Toshiki Endo, Masashi Aoki

Clinical Neurology　52　(8)　571-575　2012/08
Publisher: (一社)日本神経学会
DOI： 10.5692/clinicalneurol.52.571 　

ISSN： 0009-918X
遺伝性圧脆弱性ニューロパチーに甲状腺機能低下症を合併した一例

金子仁彦, 菅野直人, 三須建郎, 竪山真規, 鈴木直輝, 青木正志

臨床神経学　52　(7)　526　2012/07/01

ISSN： 0009-918X
【脊髄疾患の新しい話題】視神経脊髄炎における脊髄病変

高井良樹, 三須建郎, 高橋利幸, 中島一郎, 藤原一男

神経内科　77　(1)　49-57　2012/07
Publisher: (有)科学評論社
ISSN： 0386-9709
【NMO spectrumとAQP4の病態意義】 NMOにおけるAQP4の病態意義

高井良樹, 三須建郎, 高崎利幸, 中島一郎, 藤原一男

神経内科　76　(6)　543-548　2012/06
Publisher: (有)科学評論社
ISSN： 0386-9709
【NMO spectrumとAQP4の病態意義】 NMOの治療

西山修平, 三須建郎, 佐藤ダグラス, 中島一郎, 藤原一男

神経内科　76　(6)　564-568　2012/06
Publisher: (有)科学評論社
ISSN： 0386-9709
【神経疾患のバイオマーカー】視神経脊髄炎のバイオマーカー

三須建郎, 高橋利幸, 中島一郎, 藤原一男

BRAIN and NERVE: 神経研究の進歩　64　(5)　525-535　2012/05
Publisher: (株)医学書院
ISSN： 1881-6096

eISSN： 1344-8129
Aquaporin-4 antibody-positive Male Patients: A Study of 151 Cases from Japan

D. K. Sato, T. Takahashi, Nakashima, I, T. Misu, C. Kanaoka-Suzuki, Y. Kanamori, Y. Takai, S. Nishiyama, H. Kuroda, Y. Itoyama, K. Fujihara, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　18　(4)　527-527　2012/04

ISSN： 1352-4585
Evaluation of the Health-related Quality of Life in NMO

Y. Kanamori, Nakashima, I, Y. Takai, S. Nishiyama, H. Kuroda, T. Takahashi, C. Kanaoka-Suzuki, T. Misu, K. Fujihara, Y. Itoyama

MULTIPLE SCLEROSIS JOURNAL　18　(4)　539-539　2012/04

ISSN： 1352-4585
The Effect of NMO-IgG and Complement against Primary Human Astrocytes in Culture

S. Nishiyama, T. Misu, T. Takahashi, Nakashima, I, M. Aoki, K. Fujihara

MULTIPLE SCLEROSIS JOURNAL　18　(4)　540-541　2012/04

ISSN： 1352-4585
【圧迫性脊椎脊髄疾患と鑑別を要する神経・筋疾患】多発性硬化症と視神経脊髄炎診断と治療の進歩

三須建郎, 藤原一男

脊椎脊髄ジャーナル　25　(2)　99-106　2012/02
Publisher: (株)三輪書店
ISSN： 0914-4412
炎症性筋疾患の生検筋におけるFOXP3陽性細胞の検討

竪山真規, 三須建郎, 藤原一男

臨床神経学　51　(12)　1296-1296　2011/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
アストロサイトパチーと二次性脱髄に関する実験的・病理学的検証

三須建郎, Lassmann Hans, 高井良樹, 西山修平, 高橋利幸, 中島一郎, 藤原一男, 糸山泰人

臨床神経学　51　(12)　1207-1207　2011/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
視神経脊髄型多発性硬化症(OSMS)におけるInterferon-β(IFNβ)の治療効果

清水優子, 藤原一男, 久保幸子, 三須建郎, 高橋利幸, 中島一郎, 横山和正, 糸山泰人, 内山真一郎

臨床神経学　51　(12)　1284-1284　2011/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
視神経脊髄炎における痛みの評価とQOLに対する影響

中島一郎, 金森洋子, 高井良樹, 西山修平, 鈴木千尋, 三須建郎, 藤原一男, 糸山泰人

臨床神経学　51　(12)　1314-1314　2011/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
神経疾患とヒトカルジオウイルスSaffold Virusの関係

大原義朗, 姫田敏樹, 村木靖, 大桑孝子, 西山修平, 高橋利幸, 藤盛寿一, 三須建郎, 中島一郎, 藤原一男, 糸山泰人

臨床神経学　51　(12)　1373-1373　2011/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X
ヒトアストロサイト一次培養細胞に対する視神経脊髄炎患者IgG・補体の影響

西山修平, 三須建郎, 塗谷睦生, 高橋利幸, 中島一郎, 安井正人, 藤原一男, 糸山泰人

臨床神経学　51　(12)　1396-1396　2011/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
脊髄円錐・馬尾に病変を認めた抗アクアポリン4抗体陽性視神経脊髄炎の2症例

高井良樹, 三須建郎, 中島一郎, 高橋利幸, 小林篤史, 北本哲之, 藤原一男, 糸山泰人

臨床神経学　51　(12)　1449-1449　2011/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
【アストロサイト-その驚くべき多彩な機能】視神経脊髄炎(NMO)とアストロサイト

三須建郎

Clinical Neuroscience　29　(11)　1303-1307　2011/11
Publisher: (株)中外医学社
ISSN： 0289-0585
The effect of NMO-IgG and complement against primary human astrocytes in culture

S. Nishiyama, T. Misu, T. Takahashi, I. Nakashima, M. Aoki, K. Fujihara

MULTIPLE SCLEROSIS JOURNAL　17　S352-S352　2011/10

ISSN： 1352-4585

eISSN： 1477-0970
Two cases of lumbosacral myeloradiculitis with anti aquaporin-4 antibody

Y. Takai, T. Misu, I. Nakashima, M. Aoki, K. Fujihara

MULTIPLE SCLEROSIS JOURNAL　17　S237-S238　2011/10

ISSN： 1352-4585

eISSN： 1477-0970
Histopathological examination of astrocytopathy in tumefactive inflammatory diseases

T. Misu, Y. Takai, M. Watanabe, I. Nakashima, Y. Itoyama, M. Aoki, K. Fujihara

MULTIPLE SCLEROSIS JOURNAL　17　S289-S290　2011/10

ISSN： 1352-4585

eISSN： 1477-0970
Effects of immunosuppressants on in vitro production of anti-aquaporin-4 antibody from peripheral B cells of neuromyelitis optica

C. Kanaoka-Suzuki, I. Nakashima, T. Takahashi, T. Misu, K. Fujihara, M. Aoki

MULTIPLE SCLEROSIS JOURNAL　17　S203-S203　2011/10

ISSN： 1352-4585

eISSN： 1477-0970
神経疾患におけるSaffold virus感染の疫学的調査

大原義朗, 姫田敏樹, 大桑孝子, 村木靖, 西山修平, 高橋利幸, 藤盛寿一, 三須建郎, 中島一郎, 藤原一男, 糸山泰人, 石崎義人, 原寿郎

NEUROINFECTION　16　(2)　165-165　2011/10
Publisher: 日本神経感染症学会
ISSN： 1348-2718
【神経免疫の新展開】視神経脊髄炎(NMO)の病態と治療 (炎症と免疫)

鈴木千尋, 三須建郎, 佐藤ダグラス, 西山修平, 高橋利幸, 中島一郎, 糸山泰人, 藤原一男

炎症と免疫　19　(6)　564-569　2011/10
Publisher: (株)先端医学社
ISSN： 0918-8371
【神経免疫の新展開】視神経脊髄炎(NMO)の病態と治療

鈴木千尋, 三須建郎, 佐藤ダグラス, 西山修平, 高橋利幸, 中島一郎, 糸山泰人, 藤原一男

炎症と免疫　19　(6)　564-569　2011/10
Publisher: (株)先端医学社
ISSN： 0918-8371
NMO-2 腫瘍様炎症性脱髄性疾患におけるアストロサイト障害の検討

高井良樹, 三須建郎, 中島一郎, 渡邉みか, 青木正志, 藤原一男

日本神経免疫学会学術集会抄録集　23回　91-91　2011/09
Publisher: 日本神経免疫学会
ヒトアストロサイト一次培養細胞に対する視神経脊髄炎患者IgG・補体の影響

西山修平, 三須建郎, 高橋利幸, 中島一郎, 藤原一男, 青木正志

日本神経免疫学会学術集会抄録集　23回　114-114　2011/09
Publisher: 日本神経免疫学会
【神経内科疾患の新規治療】視神経脊髄炎(NMO)の治療 (神経内科)

佐藤ダグラス, 西山修平, 三須建郎, 中島一郎, 藤原一男

神経内科　74　(6)　545-549　2011/06
Publisher: (有)科学評論社
ISSN： 0386-9709
【神経内科疾患の新規治療】視神経脊髄炎(NMO)の治療

佐藤ダグラス, 西山修平, 三須建郎, 中島一郎, 藤原一男

神経内科　74　(6)　545-549　2011/06
Publisher: (有)科学評論社
ISSN： 0386-9709
【多発性硬化症と視神経脊髄炎】視神経脊髄炎の病態あらたな疾患概念"アストロサイトパチー" (医学のあゆみ)

三須建郎

医学のあゆみ　237　(4)　297-302　2011/04
【多発性硬化症と視神経脊髄炎】視神経脊髄炎の病態あらたな疾患概念"アストロサイトパチー"

三須建郎

医学のあゆみ　237　(4)　297-302　2011/04
Publisher: 医歯薬出版(株)
ISSN： 0039-2359
ヒトカルジオウイルスと免疫性神経疾患の関連<第一報>

大原義朗, 姫田敏樹, 大桑孝子, 村木靖, 西山修平, 高橋利幸, 藤盛寿一, 三須建郎, 中島一郎, 藤原一男, 糸山泰人

厚生労働省科学研究費補助金難治性疾患克服研究事業免疫性神経疾患に関する調査研究班平成22年度総括・分担報告書　105-106　2011
多施設における多発性硬化症および類縁神経疾患のCSFプロテオミクスパターン解析

小森美華, 松山由美子, 韮澤崇, 田中正美, 斎田孝彦, 三須建郎, 藤原一男, 冨本秀和, 伊東秀文, 高橋良輔, 田代啓, 池川雅哉, 近藤誉之

臨床神経学　50　(12)　1155-1155　2010/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
NMO-IgGによるヒトアストロサイト一次培養細胞の補体依存性・非依存性の変化

西山修平, 三須建郎, 塗谷睦生, 高野里菜, 高橋利幸, 中島一郎, 安井正人, 藤原一男, 糸山泰人

臨床神経学　50　(12)　1074-1074　2010/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
NMOのrituximab治療における抗AQP4抗体価の変動と血清BAFFの関連について

中島一郎, 高橋利幸, 鈴木千尋, Cree Bruce, Bar Or Amit, 三須建郎, 藤原一男, 糸山泰人

臨床神経学　50　(12)　1087-1087　2010/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
視神経脊髄炎における経口ステロイド剤の再発予防効果

高井良樹, 中島一郎, 高橋利幸, 三須建郎, 藤原一男, 糸山泰人

臨床神経学　50　(12)　1139-1139　2010/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
【MS(多発性硬化症)とNMO(視神経脊髄炎)】 NMOの病理・病態の特徴免疫介在性アストロサイトパチー (Brain Medical)

三須建郎, 藤原一男

Brain Medical　22　(4)　337-344　2010/12
Publisher: (株)メディカルレビュー社
ISSN： 0915-5759
【MS(多発性硬化症)とNMO(視神経脊髄炎)】 NMOの病理・病態の特徴免疫介在性アストロサイトパチー

三須建郎, 藤原一男

Brain Medical　22　(4)　337-344　2010/12
Publisher: (株)メディカルレビュー社
ISSN： 0915-5759
味覚障害を認めた慢性炎症性脱髄性多発根神経炎の1例

菅野直人, 川口典彦, 遠藤薫, 三須建郎, 中島一郎, 竪山真規, 糸山泰人

末梢神経　21　(2)　274-275　2010/12
Publisher: 日本末梢神経学会
ISSN： 0917-6772
Evaluation of characteristic features of pain in neuromyelitis optica and its impact on quality of life

Y. Kanamori, I. Nakashima, Y. Takai, S. Nishiyama, H. Kuroda, T. Takahashi, C. Suzuki, T. Misu, K. Fujihara, Y. Itoyama

MULTIPLE SCLEROSIS　16　(10)　1292-1292　2010/10

ISSN： 1352-4585
Effective protocol for NMO attack prevention by oral prednisolone

I. Nakashima, Y. Takai, T. Misu, T. Takahashi, Y. Fujihara, Itoyama

MULTIPLE SCLEROSIS　16　(10)　1294-1294　2010/10

ISSN： 1352-4585
【視神経脊髄炎(NMO) update】 NMOの病態機序をめぐる新たな展開 (BRAIN and NERVE: 神経研究の進歩)

三須建郎, 高橋利幸, 西山修平, 高野里菜, 中島一郎, 藤原一男, 糸山泰人

BRAIN and NERVE: 神経研究の進歩　62　(9)　921-931　2010/09
Publisher: (株)医学書院
ISSN： 1881-6096

eISSN： 1344-8129
【視神経脊髄炎(NMO) update】 NMOの病態機序をめぐる新たな展開

三須建郎, 高橋利幸, 西山修平, 高野里菜, 中島一郎, 藤原一男, 糸山泰人

BRAIN and NERVE: 神経研究の進歩　62　(9)　921-931　2010/09
Publisher: (株)医学書院
ISSN： 1881-6096

eISSN： 1344-8129
視床失語を呈したtumefactive demyelinating diseaseの1例

加藤量広, 菅野直人, 井泉瑠美子, 馬場徹, 高井良樹, 三須建郎, 鈴木直輝, 長谷川隆文, 中島一郎, 糸山泰人, 園田順彦, 隈部俊宏, 渡辺みか

臨床神経学　50　(8)　597-597　2010/08/01
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
【Neuromyelitis optica(NMO)】 NMOの病理学的特徴 (脊椎脊髄ジャーナル)

三須建郎, 藤原一男, 糸山泰人

脊椎脊髄ジャーナル　23　(8)　757-763　2010/08
Publisher: (株)三輪書店
ISSN： 0914-4412
【Neuromyelitis optica(NMO)】 NMOの病理学的特徴

三須建郎, 藤原一男, 糸山泰人

脊椎脊髄ジャーナル　23　(8)　757-763　2010/08
Publisher: (株)三輪書店
ISSN： 0914-4412
【広範囲血液・尿化学検査免疫学的検査[第7版] その数値をどう読むか】免疫学的検査自己抗体アクアポリン4(AQP4)抗体 (日本臨床)

三須建郎, 高橋利幸, 藤原一男

日本臨床　68　(増刊6 広範囲血液・尿化学検査免疫学的検査(3))　655-659　2010/06
Publisher: 日本臨床社
ISSN： 0047-1852
【広範囲血液・尿化学検査免疫学的検査[第7版] その数値をどう読むか】免疫学的検査自己抗体アクアポリン4(AQP4)抗体

三須建郎, 高橋利幸, 藤原一男

日本臨床　68　(増刊6 広範囲血液・尿化学検査免疫学的検査(3))　655-659　2010/06
Publisher: (株)日本臨床社
ISSN： 0047-1852
【免疫性神経疾患新たな治療戦略に向けて】代表的な中枢神経の自己免疫疾患 Neuromyelitis optica(NMO)の病態と病理 (内科)

高井良樹, 三須建郎, 藤原一男, 糸山泰人

内科　105　(5)　773-777　2010/05
【免疫性神経疾患新たな治療戦略に向けて】代表的な中枢神経の自己免疫疾患 Neuromyelitis optica(NMO)の病態と病理

高井良樹, 三須建郎, 藤原一男, 糸山泰人

内科　105　(5)　773-777　2010/05
Publisher: (株)南江堂
ISSN： 0022-1961
MS/NMO NMO患者における髄液中アストロサイトマーカーの検討

高野里菜, 三須建郎, 高橋利幸, 佐藤滋, 藤原一男, 糸山泰人

日本神経免疫学会学術集会抄録集　22回　39-39　2010/03
Publisher: 日本神経免疫学会
神経免疫実験モデル脱髄型EAEマウスを用いた視神経脊髄炎(NMO)の免疫学的検討

田川朝子, 荒浪利昌, 山村隆, 三須建郎, 藤原一男, 飛梅実, 佐多徹太郎

日本神経免疫学会学術集会抄録集　22回　65-65　2010/03
Publisher: 日本神経免疫学会
CIDPによる再発性味覚障害に対して免疫学的治療が奏功した一例

川口典彦, 菅野直人, 三浦永美子, 三須建郎, 中島一郎, 竪山真規, 糸山泰人

臨床神経学　50　(3)　203-203　2010/03
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
グリア細胞の神経免疫学視神経脊髄炎患者血清抽出IgGによるアストロサイト一次培養細胞への影響

西山修平, 三須建郎, 塗谷睦生, 高野里奈, 高橋利幸, 中島一郎, 安井正人, 藤原一男, 糸山泰人

日本神経免疫学会学術集会抄録集　22回　53-53　2010/03
Publisher: 日本神経免疫学会
MS/NMO 視神経脊髄炎における経口ステロイド剤の再発予防効果

高井良樹, 中島一郎, 高橋利幸, 三須建郎, 藤原一男, 糸山泰人

日本神経免疫学会学術集会抄録集　22回　56-56　2010/03
Publisher: 日本神経免疫学会
MS/NMO NMOのrituximab治療における抗AQP4抗体価の変動とBAFFの関連について

中島一郎, 高橋利幸, 鈴木千尋, クリー・ブルース, 三須建郎, 藤原一男, バーオール・アミット, 糸山泰人

日本神経免疫学会学術集会抄録集　22回　68-68　2010/03
Publisher: 日本神経免疫学会
MS/NMO Neuromyelitis optica患者髄液中の補体成分C5a上昇について

黒田宙, 高橋利幸, 高野里菜, 三須建郎, 中島一郎, 藤原一男, 糸山泰人

日本神経免疫学会学術集会抄録集　22回　67-67　2010/03
Publisher: 日本神経免疫学会
Neuromyelitis Optica(NMO) (Current Insights in Neurological Science)

高井良樹, 三須建郎, 藤原一男

Current Insights in Neurological Science　18　(1)　8-9　2010/03
Neuromyelitis Optica(NMO)

高井良樹, 三須建郎, 藤原一男

Current Insights in Neurological Science　18　(1)　8-9　2010/03
Publisher: (株)マッキャンヘルスケアワールドワイドジャパン
ISSN： 0918-9645
NMO患者における髄液中アストロサイトマーカーの検討

高野里菜, 三須建郎, 高橋利幸, 佐藤滋, 藤原一男, 糸山泰人

臨床神経学　49　(12)　1057-1057　2009/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
発症前長期にわたりAQP4抗体が陽性であったNMOの1例

西山修平, 伊藤孝, 三須建郎, 高橋利幸, 菊池昭夫, 鈴木直輝, 神一敬, 青木正志, 藤原一男, 糸山泰人

臨床神経学　49　(12)　1035-1035　2009/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
Neuromyelitis opticaにおける脳梁病変の特徴

中村正史, 三須建郎, 藤原一男, 中島一郎, 糸山泰人

臨床神経学　49　(12)　1109-1109　2009/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
NMOにおける単純血漿交換療法の検討

高橋利幸, 笠原砂由子, 宮澤イザベル, 高野里菜, 金森洋子, 西山修平, 鈴木千尋, 三須建郎, 中島一郎, 藤原一男, 糸山泰人

臨床神経学　49　(12)　1109-1109　2009/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
Pathology of NMO (臨床神経学)

三須建郎

臨床神経学　49　(11)　896-899　2009/11

DOI： 10.5692/clinicalneurol.49.896 　
Pathology of NMO

三須建郎

臨床神経学　49　(11)　896-899　2009/11
Publisher: (一社)日本神経学会
DOI： 10.5692/clinicalneurol.49.896 　

ISSN： 0009-918X

eISSN： 1882-0654
Therapy for Neuromyelitis Optica : Recent Evidence

NISHIYAMA Shuhei, MISU Tatsuro, NAKASHIMA Ichiro, TAKAHASHI Toshiyuki, NAKAMURA Masashi, SATO Shigeru, FUJIHARA Kazuo, ITOYAMA Yasuto

Journal of the eye　26　(10)　1323-1327　2009/10/30
Publisher: メディカル葵出版
ISSN： 0910-1810
【多発性硬化症・視神経脊髄炎と抗アクアポリン4抗体】視神経脊髄炎の病理学的特徴 (あたらしい眼科)

三須建郎, 藤原一男, 糸山泰人

あたらしい眼科　26　(10)　1307-1314　2009/10
Publisher: (株)メディカル葵出版
ISSN： 0910-1810
【多発性硬化症・視神経脊髄炎と抗アクアポリン4抗体】視神経脊髄炎の病理学的特徴

三須建郎, 藤原一男, 糸山泰人

あたらしい眼科　26　(10)　1307-1314　2009/10
Publisher: (株)メディカル葵出版
ISSN： 0910-1810
Increase of cerebrospinal fluid anaphylatoxin C5a in neuromyelitis optica

H. Kuroda, T. Takahashi, R. Takano, T. Misu, I. Nakashima, K. Fujihara, Y. Itoyama

MULTIPLE SCLEROSIS　15　(9)　S76-S76　2009/09

ISSN： 1352-4585
Changes of aquaporin4 antibody-treated primary human astrocytes in culture: a time-lapse microscopic analysis

S. Nishiyama, T. Misu, R. Takano, T. Takahashi, I. Nakashima, K. Fujihara, Y. Itoyama

MULTIPLE SCLEROSIS　15　(9)　S76-S77　2009/09

ISSN： 1352-4585
Therapeutic efficacy of interferon beta-1b in Japanese optic-spinal multiple sclerosis patients

Y. Shimizu, K. Fujihara, S. Kubo, T. Misu, I. Nakashima, K. Yokoyama, Y. Itoyama, S. Uchiyama

MULTIPLE SCLEROSIS　15　(9)　S258-S259　2009/09

ISSN： 1352-4585
【多発性硬化症病態解明と治療戦略の最前線(NMOを含めて)】多発性硬化症の病態と治療多発性硬化症の神経病理 (カレントテラピー)

三須建郎, 藤原一男, 糸山泰人

カレントテラピー　27　(9)　759-763　2009/09
Publisher: (株)ライフメディコム
ISSN： 0287-8445
【多発性硬化症病態解明と治療戦略の最前線(NMOを含めて)】多発性硬化症の病態と治療多発性硬化症の神経病理

三須建郎, 藤原一男, 糸山泰人

カレントテラピー　27　(9)　759-763　2009/09
Publisher: (株)ライフメディコム
ISSN： 0287-8445
両側外眼筋麻痺で発症した下垂体卒中の1例

高井良樹, 小林理子, 三須建郎, 中島一郎, 糸山泰人, 小川欣一

臨床神経学　49　(8)　502-502　2009/08
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
高齢で発症した遺伝性圧脆弱性ニューロパチーの2例

川口典彦, 鈴木直輝, 竪山真規, 高井良樹, 水野秀紀, 松田基弘, 三須建郎, 中島一郎, 糸山泰人

臨床神経学　49　(8)　504-504　2009/08/01
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
視神経脊髄炎とアストロサイトパチー髄液中GFAPの有用性 (東北医学雑誌)

三須建郎

東北医学雑誌　121　(1)　101-103　2009/06
臨床医のための神経病理 NMO(Neuromyelitis optica) (Clinical Neuroscience)

三須建郎, 藤原一男, 糸山泰人

Clinical Neuroscience　27　(6)　602-603　2009/06
Publisher: (株)中外医学社
ISSN： 0289-0585
臨床医のための神経病理 NMO(Neuromyelitis optica)

三須建郎, 藤原一男, 糸山泰人

Clinical Neuroscience　27　(6)　602-603　2009/06
Publisher: (株)中外医学社
ISSN： 0289-0585
視神経脊髄炎とアストロサイトパチー髄液中GFAPの有用性

三須建郎

東北医学雑誌　121　(1)　101-103　2009/06
Publisher: 東北医学会
ISSN： 0040-8700
NMO患者における髄液中アストロサイトマーカーの検討

高野里菜, 三須建郎, 高橋利幸, 佐藤滋, 藤原一男, 糸山泰人

神経免疫学　17　(1)　77-77　2009/03
Publisher: 日本神経免疫学会
ISSN： 0918-936X
NMOにおける単純血漿交換療法の検討

高橋利幸, 高野里菜, 宮澤イザベル, 西山修平, 鈴木千尋, 金森洋子, 三須建郎, 中島一郎, 藤原一男, 糸山泰人

神経免疫学　17　(1)　73-73　2009/03
Publisher: 日本神経免疫学会
ISSN： 0918-936X
Neuromyelitis opticaにおける脳梁病変の特徴

中村正史, 三須建郎, 藤原一男, 宮澤イザベル, 中島一郎, 高橋利幸, 渡部承平, 糸山泰人

神経免疫学　17　(1)　80-80　2009/03
Publisher: 日本神経免疫学会
ISSN： 0918-936X
発症前長期にわたりAQP4抗体が陽性であったNMOの1例

西山修平, 伊藤孝, 三須建郎, 高橋利幸, 菊池昭夫, 鈴木直輝, 神一敬, 青木正志, 藤原一男, 糸山泰人

Neuroimmunology　17　(1)　81　2009/03/01

ISSN： 0918-936X
注目される新しい病態・疾患概念と臨床検査神経疾患編視神経脊髄炎とアクアポリン4抗体多発性硬化症との相違 (臨床病理)

三須建郎, 高橋利幸, 中島一郎, 藤原一男, 糸山泰人

臨床病理　57　(3)　262-270　2009/03
Publisher: (一社)日本臨床検査医学会
ISSN： 0047-1860
注目される新しい病態・疾患概念と臨床検査神経疾患編視神経脊髄炎とアクアポリン4抗体多発性硬化症との相違

三須建郎, 高橋利幸, 中島一郎, 藤原一男, 糸山泰人

臨床病理　57　(3)　262-270　2009/03
Publisher: 日本臨床検査医学会
ISSN： 0047-1860
Aquaporin-4-antibody seroconversion occurs before the onset of neuromyelitis optica

S. Nishiyama, A. Kikuchi, N. Suzuki, K. Jin, M. Aoki, T. Takahashi, T. Misu, K. Fujihara, Y. Itoyama

MULTIPLE SCLEROSIS　15　(1)　145-145　2009/01

ISSN： 1352-4585
Marked increase of CSF GFAP in neuromyelitis optica-an astrocytic damage marker

Tatsuro Misu, Rina Takano, Kazuo Fujihara, Toshiyuki Takahashi, Shigeru Sato, Yasuto Itoyama

MULTIPLE SCLEROSIS　15　(1)　146-146　2009/01

ISSN： 1352-4585
発症前長期にわたりAQP4抗体が陽性であったNMOの1例

西山修平, 伊藤孝, 三須建郎, 高橋利幸, 菊池昭夫, 鈴木直輝, 神一敬, 青木正志, 藤原一男, 糸山泰人

日本神経学会総会プログラム・抄録集　50th　190　2009
抗アクアポリン4抗体陽性視神経脊髄炎症例における抗体価の経時的変化とその特徴

高野里菜, 高橋利幸, 三須建郎, 藤原一男, 糸山泰人

臨床神経学　48　(12)　1050-1050　2008/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
抗アクアポリン4抗体陽性多数例の臨床解析

高橋利幸, 高野里菜, 三須建郎, 藤原一男, 糸山泰人

臨床神経学　48　(12)　1050-1050　2008/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
封入体筋炎におけるCCL19、CCL21/CCR7ケモカイン系の検討

竪山真規, 藤原一男, 三須建郎, 糸山泰人

臨床神経学　48　(12)　1174-1174　2008/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
視神経脊髄炎(NMO)におけるアストロサイト障害の関連

三須建郎, 藤原一男, 柿田明美, 高野里菜, 高橋利幸, 高橋均, 糸山泰人

臨床神経学　48　(12)　1217-1217　2008/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
健常者及び多発性硬化症患者における免疫グロブリンGの樹状細胞分化の修飾

藤原一男, 大隈浩一, 佐々木巧, 亀井慎太郎, 奥田祥士, 中野宏俊, 濱本高義, 中島一郎, 三須建郎, 糸山泰人

臨床神経学　48　(12)　1236-1236　2008/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
【抗アクアポリン4抗体関連神経疾患の病態】 NMOの診断と病態におけるアクアポリン4抗体の意義 (神経免疫学)

藤原一男, 三須建郎, 高橋利幸, 中島一郎, 中村正史, 佐藤滋, 糸山泰人

神経免疫学　16　(2)　155-159　2008/12
Publisher: 日本神経免疫学会
ISSN： 0918-936X
【抗アクアポリン4抗体関連神経疾患の病態】 NMOの診断と病態におけるアクアポリン4抗体の意義

藤原一男, 三須建郎, 高橋利幸, 中島一郎, 中村正史, 佐藤滋, 糸山泰人

神経免疫学　16　(2)　155-159　2008/12
Publisher: 日本神経免疫学会
ISSN： 0918-936X
新しい神経治療をめぐって多発性硬化症と視神経脊髄炎の治療Update (神経治療学)

藤原一男, 中島一郎, 三須建郎, 高橋利幸, 渡辺承平, 中村正史, 佐藤滋, 糸山泰人

神経治療学　25　(6)　701-706　2008/11
Publisher: (一社)日本神経治療学会
ISSN： 0916-8443

eISSN： 2189-7824
新しい神経治療をめぐって多発性硬化症と視神経脊髄炎の治療Update

藤原一男, 中島一郎, 三須建郎, 高橋利幸, 渡辺承平, 中村正史, 佐藤滋, 糸山泰人

神経治療学　25　(6)　701-706　2008/11
Publisher: 日本神経治療学会
ISSN： 0916-8443

eISSN： 2189-7824
病変が脳幹部に限局したNMOの一例

入野樹美, 佐藤滋, 望月るり子, 大沼歩, 野村宏, 藤盛寿一, 高橋利幸, 三須建朗, 藤原一男, 糸山泰人

臨床神経学　48　(10)　760-760　2008/10
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
大脳病変に伴う視神経炎で発症し、単純血漿交換を施行した1例

金岡千尋, 小林理子, 三須建郎, 菊池昭夫, 青木正志, 藤原一男, 糸山泰人, 相澤裕, 相馬龍子, 村田弥栄子, 城田祐子, 佐藤壽伸, 菅原克幸, 菅原由美, 加藤潔

日本アフェレシス学会雑誌　27　(3)　245-245　2008/10
Publisher: (一社)日本アフェレシス学会
ISSN： 1340-5888
脊髄炎と鑑別を要した脊髄梗塞の1例

今野昌俊, 佐藤滋, 望月るり子, 大沼歩, 野村宏, 遠藤俊毅, 近藤竜史, 井上敬, 高橋利幸, 三須建朗, 中島一郎, 藤原一男, 糸山泰人

臨床神経学　48　(10)　759-759　2008/10
Publisher: (一社)日本神経学会
ISSN： 0009-918X
口唇ヘルペス感染に伴って橋内三叉神経路病変を来した再発性脊髄炎の1例

上野聖平, 水野秀紀, 鈴木直輝, 田野大人, 三須建郎, 藤原一男, 中島一郎, 糸山泰人

臨床神経学　48　(10)　762-762　2008/10/01
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
【神経疾患と自己抗体】アクアポリン4抗体と視神経脊髄炎(NMO) (神経内科)

藤原一男, 三須建郎, 高橋利幸, 中島一郎, 糸山泰人

神経内科　69　(4)　367-371　2008/10
Publisher: (有)科学評論社
ISSN： 0386-9709
【神経疾患と自己抗体】アクアポリン4抗体と視神経脊髄炎(NMO)

藤原一男, 三須建郎, 高橋利幸, 中島一郎, 糸山泰人

神経内科　69　(4)　367-371　2008/10
Publisher: (有)科学評論社
ISSN： 0386-9709
Aquaporin-4-antibody seroconversion occurs before the onset of neuromyelitis optica

Shuhei Nishiyama, Akio Kikuchi, Naoki Suzuki, Kazutaka Jin, Masashi Aoki, Toshiyuki Takahashi, Tatsuro Misu, Kazuo Fujihara, Yasuto Itoyama

MULTIPLE SCLEROSIS　14　S237-S237　2008/09

ISSN： 1352-4585
Marked increase of cerebrospinal fluid glial fibrillary acidic protein in neuromyelitis optica: an astrocytic damage marker

Rina Takane, Tatsuro Misu, Kazuo Fujihara, Toshiyuki Takahashi, Shigeru Sato, Yasuto Itoyama

MULTIPLE SCLEROSIS　14　S289-S289　2008/09

ISSN： 1352-4585
【多発性硬化症最近のトピック】アクアポリンとNMO NMOとアクアポリン4抗体の病理学的意義アストロサイトに注目して (Clinical Neuroscience)

三須建郎, 藤原一男, 糸山泰人

Clinical Neuroscience　26　(7)　770-773　2008/07
【多発性硬化症最近のトピック】アクアポリンとNMO NMOとアクアポリン4抗体の病理学的意義アストロサイトに注目して

三須建郎, 藤原一男, 糸山泰人

Clinical Neuroscience　26　(7)　770-773　2008/07
Publisher: (株)中外医学社
ISSN： 0289-0585
視神経脊髄炎とアクアポリン4抗体アストログリア病との出会い (東北医学雑誌)

三須建郎

東北医学雑誌　120　(1)　58-61　2008/06
視神経脊髄炎とアクアポリン4抗体アストログリア病との出会い

三須建郎

東北医学雑誌　120　(1)　58-61　2008/06
Publisher: 東北医学会
ISSN： 0040-8700
視神経脊髄炎(NMO)とアクアポリン4抗体 (BRAIN and NERVE: 神経研究の進歩)

三須建郎, 藤原一男, 糸山泰人

BRAIN and NERVE: 神経研究の進歩　60　(5)　527-537　2008/05
視神経脊髄炎(NMO)とアクアポリン4抗体

三須建郎, 藤原一男, 糸山泰人

BRAIN and NERVE: 神経研究の進歩　60　(5)　527-537　2008/05
Publisher: (株)医学書院
ISSN： 1881-6096
抗アクアポリン4抗体関連神経疾患の病態機序 Neuromyelitis opticaの病巣におけるアストロサイト障害の検討

三須建郎, 藤原一男, 高野里菜, 高橋利幸, 柿田明美, 今野秀彦, 高橋均, 糸山泰人

神経免疫学　16　(1)　51-51　2008/04
Publisher: 日本神経免疫学会
ISSN： 0918-936X
Expression of CCL19,CCL21/CCR7 chemokine system in muscles of patients with inclusion body myositis

Maki Tateyama, Kazuo Fujihara, Tatsuro Misu, Yasuto Itoyama

NEUROLOGY　70　(11)　A303-A303　2008/03

ISSN： 0028-3878

eISSN： 1526-632X
Development of extensive brain lesions following interferon-beta therapy in relapsing neuromyelitis optica and longitudinally extensive myelitis with anti-aquaporin-4 antibody

Yuko Shimizu, Kazumasa Yokoyama, Tatsuro Misu, Kazuo Fujihara, Yoshiyuki Takahashi, Seiji Kikichi, Yasuto Itoyama, Makoto Iwata

NEUROLOGY　70　(11)　A268-A269　2008/03

ISSN： 0028-3878

eISSN： 1526-632X
脳幹病変を認め神経Behcet病が疑われた女性例の臨床的検討

西山修平, 菊池昭夫, 加藤量広, 三須建郎, 神一敬, 志賀裕正, 藤原一男, 糸山泰人

臨床神経学　48　(2)　147-147　2008/02
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
Pathological significance of Aquaporin 4 in neuromyelitis optica (Neuroimmunology)

Tatsuro Misu

Neuroimmunology　15　(2)　157-162　2008/02
封入体筋炎におけるCCR7/CCL19、CCL21ケモカイン系の検討

竪山真規, 藤原一男, 三須建郎, 小野寺好明, 糸山泰人

臨床神経学　47　(12)　1183-1183　2007/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
抗アクアポリン4抗体アッセイ系の確立およびNMO-IgGとの比較検討

高橋利幸, 藤原一男, 中島一郎, 三須建郎, 宮澤イザベル, 中村正史, 渡部承平, 糸山泰人

臨床神経学　47　(12)　1127-1127　2007/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
Neuromyelitis opticaの脊髄病巣におけるアクアポリン4の欠落

三須建郎, 藤原一男, 柿田明美, 今野秀彦, 中村正志, 渡辺承平, 高橋利幸, 中島一郎, 高橋均, 糸山泰人

臨床神経学　47　(12)　1127-1127　2007/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
アストロサイトの障害によって起こる視神経脊髄炎の研究アクアポリン4抗体の意義 (Proceedings of Clinical Electron Microscopy)

三須建郎

Proceedings of Clinical Electron Microscopy　27　15-19　2007/12
アストロサイトの障害によって起こる視神経脊髄炎の研究アクアポリン4抗体の意義

三須建郎

Proceedings of Clinical Electron Microscopy　27　15-19　2007/12
Publisher: 東北臨床超微形態懇話会世話人会
【アクアポリンと多発性硬化症】視神経脊髄炎におけるアクアポリン4の病理学的意義

三須建郎

神経免疫学　15　(2)　157-162　2007/11
Publisher: 日本神経免疫学会
ISSN： 0918-936X
地域医療を担う医師への生涯学習支援東北大学講習会2年間の結果より

溝口二郎, 小笠原博信, 木村秀樹, 金塚完, 三須建郎, 金村政輝, 伊藤恒敏, 本郷道夫

日本公衆衛生学会総会抄録集　66回　382-382　2007/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
Loss of aquaporin 4 and astroglial changes in lesions of neuromyelitis optica: distinction from multiple sclerosis

T. Misu, K. Fujihara, A. Kakita, H. Konno, M. Nakamura, S. Watanabe, T. Takahashi, I. Nakashima, H. Takahashi, Y. Itoyama

MULTIPLE SCLEROSIS　13　S143-S143　2007/10

ISSN： 1352-4585
インターネットを活用した医師生涯学習支援システムの構築(東北大学診断・治療情報コンテンツライブラリー)

溝口二郎, 金村政輝, 木村秀樹, 小笠原博信, 三須建郎, 金塚完, 本郷道夫, 伊藤恒敏

医学教育　38　(Suppl.)　99-99　2007/06
Publisher: (一社)日本医学教育学会
ISSN： 0386-9644
視神経脊髄炎における低用量連日プレドニゾロン投与の再発抑制効果

渡部承平, 三須建郎, 宮澤イザベル, 中島一郎, 志賀裕正, 藤原一男, 糸山泰人

神経免疫学　15　(1)　41-41　2007/04
Publisher: 日本神経免疫学会
ISSN： 0918-936X
抗アクアポリン4抗体とNMO-IgGの比較検討

高橋利幸, 中村正史, 三須建郎, 中島一郎, 藤原一男, 糸山泰人

神経免疫学　15　(1)　47-47　2007/04
Publisher: 日本神経免疫学会
ISSN： 0918-936X
視神経脊髄炎(NMO)の病理学的検討アクアポリン4、アストログリアを起因とする疾患群

三須建郎, 藤原一男, 柿田明美, 今野秀彦, 中村正志, 渡辺承平, 高橋利幸, 中島一郎, 高橋均, 糸山泰人

神経免疫学　15　(1)　48-48　2007/04
Publisher: 日本神経免疫学会
ISSN： 0918-936X
脊髄MRI軸位断でのNeuromyelitis opticaとmultiple sclerosisの画像所見の比較

中村正史, 宮澤イザベル, 藤原一男, 中島一郎, 三須建郎, 渡部承平, 高橋利幸, 糸山泰人

神経免疫学　15　(1)　96-96　2007/04
Publisher: 日本神経免疫学会
ISSN： 0918-936X
Two patients with lower motor neuron diseases following generalized muscle cramps and fasciculations

TATEYAMA Maki, MISU Tatsuro, ONODERA Yoshiaki, SHIGA Yusei, ITOYAMA Yasuto

17　(2)　206-208　2006/12/01

ISSN： 0917-6772
HAMにおけるインターフェロンα療法前後のNF-kB関連cDNAマイクロアレイ解析

藤原一男, 馮娟, 三須建郎, 糸山泰人

臨床神経学　46　(12)　1029-1029　2006/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
炎症性筋疾患の筋組織におけるCCR7/CCL19,CCL21系発現の検討

竪山真規, 藤原一男, 三須建郎, 小野寺好明, 糸山泰人

臨床神経学　46　(12)　1172-1172　2006/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
NMO-IgG陽性視神経脊髄型多発性硬化症患者6例における血漿交換療法の有効性

渡部承平, 中島一郎, 三須建郎, 宮沢イザベル, 志賀裕正, 藤原一男, 糸山泰人, 中川陽一

臨床神経学　46　(12)　1094-1094　2006/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
視神経脊髄型多発性硬化症の脊髄病巣における血管変化とAQP4の関連

三須建郎, 藤原一男, 柿田明美, 中島一郎, 高橋均, 糸山泰人

臨床神経学　46　(12)　1155-1155　2006/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
視神経脊髄型多発性硬化症における血漿交換療法の有効性の検討

渡部承平, 中島一郎, 三須建朗, 宮澤イザベル, 志賀裕正, 藤原一男, 糸山泰人, 菅原克幸, 菅原由美, 加藤潔, 佐藤寿伸

日本アフェレシス学会雑誌　25　(3)　252-252　2006/10
Publisher: (一社)日本アフェレシス学会
ISSN： 1340-5888
Brain MRI findings in Japanese MS patients with NMO-IgG

I. Nakashima, K. Fujihara, I. Miyazawa, T. Misu, Y. Itoyama

JOURNAL OF NEUROIMMUNOLOGY　178　217-217　2006/09

ISSN： 0165-5728
Long-term corticosteroid administration prevents relapse in neuromyelitis optica

S. Watanabe, T. Misu, K. Fujihara, I. Nakashima, I. Miyazawa, Y. Shiga, Y. Itoyama

MULTIPLE SCLEROSIS　12　S104-S104　2006/09

ISSN： 1352-4585
Large "cystic" cerebral lesions in multiple sclerosis patients after discontinuation of IFN beta-1b: A report of two cases

T. Takahashi, I. Nakashima, T. Misu, Y. Shiga, K. Fujihara, Y. Itoyama

JOURNAL OF NEUROIMMUNOLOGY　178　217-217　2006/09

ISSN： 0165-5728
Brain MRI findings in Japanese multiple sclerosis patients with NMO-IgG

M. Nakamura, I. Nakashima, K. Fujihara, I. Miyazawa, T. Misu, Y. Itoyama

MULTIPLE SCLEROSIS　12　S39-S39　2006/09

ISSN： 1352-4585
【多発性硬化症研究・治療の現状2006】視神経脊髄型多発性硬化症 (神経研究の進歩)

藤原一男, 中島一郎, 三須建郎, 宮澤イザベル, 藤盛寿一, 成川孝一, 中村正史, 高橋利幸, 渡部承平, 佐藤滋, 糸山泰人

神経研究の進歩　50　(4)　549-557　2006/08
Publisher: (株)医学書院
DOI： 10.11477/mf.1431100163 　

ISSN： 0001-8724

eISSN： 1882-1243
【多発性硬化症研究・治療の現状2006】視神経脊髄型多発性硬化症

藤原一男, 中島一郎, 三須建郎, 宮澤イザベル, 藤盛寿一, 成川孝一, 中村正史, 高橋利幸, 渡部承平, 佐藤滋, 糸山泰人

神経研究の進歩　50　(4)　549-557　2006/08
Publisher: (株)医学書院
DOI： 10.11477/mf.1431100163 　

ISSN： 0001-8724

eISSN： 1882-1243
視床下部病変による症候性ナルコレプシーにて発症した多発性硬化症の1例

馬場徹, 中島一郎, 志賀裕正, 今野昌俊, 三須建郎, 青木正志, 武田篤, 糸山泰人, 北室知巳, 小川浩正, 神林崇

臨床神経学　46　(5)　366-366　2006/05
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
IFNβ-1b中断後に無症候性巨大嚢胞状病変を生じた通常型多発性硬化症の2例

高橋利幸, 中島一郎, 三須建郎, 藤原一男, 糸山泰人

神経治療学　23　(3)　319-319　2006/05
Publisher: 日本神経治療学会
ISSN： 0916-8443

eISSN： 2189-7824
視神経脊髄型多発性硬化症における血漿交換療法の有効性の検討

渡部承平, 中島一郎, 三須建郎, 宮澤イザベル, 志賀裕正, 藤原一男, 糸山泰人

神経治療学　23　(3)　322-322　2006/05
Publisher: 日本神経治療学会
ISSN： 0916-8443

eISSN： 2189-7824
Clinical and MRI features of Japanese MS patients with NMO-IgG

Nakashima, I, K Fujihara, Miyazawa, I, T Misu, M Nakamura, S Watanabe, T Takahashi, BG Weinshenker, Y Itoyama

NEUROLOGY　66　(5)　307-307　2006/03

ISSN： 0028-3878
多発性硬化症の免疫応答抗体反応を中心に

藤原一男, 中島一郎, 三須建郎, 藤盛寿一, 成川孝一, 宮澤イザベル, 佐藤滋, 糸山泰人

神経免疫学　14　(1)　17-17　2006/03
Publisher: 日本神経免疫学会
ISSN： 0918-936X
免疫性神経疾患と自己抗体 NMO-IgG陽性多発性硬化症の臨床的・画像的特徴

中島一郎, 藤原一男, 宮沢イザベル, 中村正史, 三須建郎, 佐藤滋, 糸山泰人

神経免疫学　14　(1)　30-30　2006/03
Publisher: 日本神経免疫学会
ISSN： 0918-936X
IFNβ-1b中断後に無症候性巨大嚢胞状病変を生じた通常型多発性硬化症の2例

高橋利幸, 中島一郎, 三須建郎, 藤原一男, 糸山泰人

神経免疫学　14　(1)　120-120　2006/03
Publisher: 日本神経免疫学会
ISSN： 0918-936X
多発筋炎の筋組織におけるCCR7/CCL19,CCL21の発現

竪山真規, 藤原一男, 三須建郎, 小野寺好明, 糸山泰人

臨床神経学　45　(12)　1204-1204　2005/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
日本人視神経脊髄型多発性硬化症(OSMS)における免疫グロブリン・補体の沈着

三須建郎, 柿田明美, 藤原一男, 中島一郎, 高橋均, 糸山泰人

臨床神経学　45　(12)　1104-1104　2005/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
視神経脊髄型及び通常型多発性硬化症のCXCL8/IL-8濃度の比較解析

成川孝一, 藤原一男, 三須建郎, 宮澤イザベル, 中島一郎, 佐藤滋, 糸山泰人

臨床神経学　45　(12)　1104-1104　2005/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
【サイトカイン・ケモカインからみた多発性硬化症の病型と病態】サイトカイン,ケモカインからみた通常型多発性硬化症の免疫病態 (神経免疫学)

藤原一男, 三須建郎, 成川孝一, 中島一郎, 佐藤滋, 糸山泰人

神経免疫学　13　(2)　155-159　2005/11
Publisher: 日本神経免疫学会
ISSN： 0918-936X
【サイトカイン・ケモカインからみた多発性硬化症の病型と病態】サイトカイン,ケモカインからみた通常型多発性硬化症の免疫病態

藤原一男, 三須建郎, 成川孝一, 中島一郎, 佐藤滋, 糸山泰人

神経免疫学　13　(2)　155-159　2005/11
Publisher: 日本神経免疫学会
ISSN： 0918-936X
Clinical and MRI features of 14 Japanese MS patients with NMO-IgG

Nakashima, I, K Fujihara, Miyazawa, I, T Misu, M Nakamura, S Watanabe, VA Lennon, BG Weinshenker, Y Itoyama

MULTIPLE SCLEROSIS　11　S25-S25　2005/09

ISSN： 1352-4585
HTLV-1ミオパチーの一例

入野樹美, 三須建郎, 千葉真美, 田郷英昭, 志賀裕正, 竪山真規, 糸山泰人

臨床神経学　45　(6)　463-463　2005/06
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
血漿交換療法が奏効した視床下部病変を伴う視神経脊髄型多発性硬化症の1例

渡部承平, 中島一郎, 藤原一男, 宮澤イザベル, 三須建郎, 志賀裕正, 糸山泰人, 中川陽一

神経治療学　22　(3)　370-370　2005/05
Publisher: 日本神経治療学会
ISSN： 0916-8443

eISSN： 2189-7824
診断の指針治療の指針多発性硬化症の再発予防 (綜合臨床)

三須建郎, 藤原一男, 糸山泰人

綜合臨床　54　(4)　1415-1416　2005/04
Publisher: (株)永井書店
ISSN： 0371-1900
診断の指針治療の指針多発性硬化症の再発予防

三須建郎, 藤原一男, 糸山泰人

綜合臨床　54　(4)　1415-1416　2005/04
Publisher: (株)永井書店
ISSN： 0371-1900
CSF-chemokines in HTLV-1 associated myelopathy: CXCL10 upregulation and therapeutic effect of interferon-alpha

K Narikawa, K Fujihara, T Misu, J Feng, J Fujimori, Nakashima, I, Miyazawa, I, H Saito, S Sato, Y Itoyama

NEUROLOGY　64　(6)　A192-A192　2005/03

ISSN： 0028-3878
Expression of CCR7 and its ligand CCL19 are increased in muscles of polymyositis

M Tateyama, K Fujihara, T Misu, J Feng, Y Onodera, Y Itoyama

NEUROLOGY　64　(6)　A339-A339　2005/03

ISSN： 0028-3878
A comparative neuropathological analysis of Japanese cases of neuromyelitis optica and multiple sclerosis

T Misu, A Kakita, K Fujihara, Nakashima, I, H Takahashi, Y Itoyama

NEUROLOGY　64　(6)　A39-A39　2005/03

ISSN： 0028-3878
CSF- and serum-IL-8/CXCL-8 levels in relapsing neuromyelitis optica and multiple sclerosis

K Narikawa, K Fujihara, T Misu, Nakashima, I, S Sato, Y Itoyama

NEUROLOGY　64　(6)　A196-A197　2005/03

ISSN： 0028-3878
ケモカインからみた視神経脊髄型多発性硬化症の免疫病態

藤原一男, 成川孝一, 三須建郎, 中島一郎, 宮澤イザベル, 佐藤滋, 糸山泰人

神経免疫学　13　(1)　25-25　2005/03
Publisher: 日本神経免疫学会
ISSN： 0918-936X
OS-MSの病態視神経脊髄型及び通常型多発性硬化症剖検例の病理学的比較解析

三須建郎, 柿田明美, 藤原一男, 中島一郎, 高橋均, 糸山泰人

神経免疫学　13　(1)　67-67　2005/03
Publisher: 日本神経免疫学会
ISSN： 0918-936X
OS-MSの病態視神経脊髄型及び通常型多発性硬化症のCXCL8/IL-8濃度の比較解析

成川孝一, 藤原一男, 三須建郎, 宮澤イザベル, 中島一郎, 佐藤滋, 糸山泰人

神経免疫学　13　(1)　68-68　2005/03
Publisher: 日本神経免疫学会
ISSN： 0918-936X
HLA一致同胞間末梢血幹細胞移植後に,慢性GVHDによる全身の関節拘縮を伴う筋膜炎を合併した1例

内山徹, 杜緯, 笹原洋二, 吉成みやこ, 久間木悟, 土屋滋, 峯岸正好, 三須建郎

日本小児科学会雑誌　109　(3)　417-417　2005
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
多発筋炎の生検筋におけるCCR7,CCL19,CCL21の検討

竪山真規, 藤原一男, 三須建郎, 馮娟, 小野寺好明, 糸山泰人

臨床神経学　44　(12)　1078-1078　2004/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
日本人視神経脊髄型(OSMS)及び通常型多発性硬化症(CMS)の延髄・脊髄病変の比較解析

三須建郎, 藤原一男, 中島一郎, 柿田明美, 高橋均, 糸山泰人

臨床神経学　44　(12)　1059-1059　2004/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
視神経脊髄型及び通常型多発性硬化症における可溶性CD26及びCD30濃度の比較解析

成川孝一, 三須建郎, 藤原一男, 中島一郎, 糸山泰人

臨床神経学　44　(12)　1124-1124　2004/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
多発性硬化症及びHAMにおけるCD25high+CD4+制御性T細胞サブセットの解析

藤原一男, 馮娟, 三須建郎, 中島一郎, 佐藤滋, 糸山泰人

臨床神経学　44　(12)　1124-1124　2004/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
Vogt-Koyanagi-Harada病(VKH)における血清及び髄液ケモカイン濃度の検討

宮澤イザベル, 阿部俊明, 成川孝一, 馮娟, 三須建郎, 中島一郎, 藤盛寿一, 玉井信, 藤原一男, 糸山泰人

臨床神経学　44　(12)　1189-1189　2004/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X
【研修医のための多発性硬化症診かたと治療の進め方】多発性硬化症の診かた多発性硬化症の特殊型と類縁疾患の診断 Devic病(neuromyelitis optica) (Modern Physician)

宮澤イザベル, 藤原一男, 三須建郎, 中島一郎, 糸山泰人

Modern Physician　24　(12)　1866-1868　2004/12
Publisher: (株)新興医学出版社
ISSN： 0913-7963
Riluzole内服中に間質性肺炎を合併したALSの一例

加藤昌昭, 中島一郎, 三須建郎, 長谷川隆文, 志賀裕正, 糸山泰人

臨床神経学　44　(7)　482-482　2004/07
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
多発性硬化症と髄液オリゴクローナルバンド

中島一郎, 藤原一男, 藤盛寿一, 三須建郎, 糸山泰人

脳と神経　56　(6)　475-482　2004/06
Publisher: (株)医学書院
ISSN： 0006-8969
[Multiple sclerosis and oligoclonal IgG bands].

Ichiro Nakashima, Kazuo Fujihara, Juichi Fujimori, Tatsuro Misu, Yasuto Itoyama

No to shinkei = Brain and nerve　56　(6)　475-82　2004/06

ISSN： 0006-8969
HAM及び多発性硬化症患者の髄液ケモカイン濃度の比較解析

成川孝一, 三須建郎, 藤原一男, 中島一郎, 糸山泰人

神経治療学　21　(3)　350-350　2004/05
Publisher: 日本神経治療学会
ISSN： 0916-8443

eISSN： 2189-7824
【安全なステロイド療法のために】ステロイド療法の実際神経筋疾患のステロイド療法 (臨牀と研究)

三須建郎, 藤原一男, 糸山泰人

臨牀と研究　81　(5)　773-776　2004/05
Publisher: 大道学館出版部
ISSN： 0021-4965
Cerebrospinal fluid chemokine levels in relapsing neuromyelitis optica and multiple sclerosis

K Narikawa, T Misu, K Fujihara, Nakashima, I, S Sato, Y Itoyama

NEUROLOGY　62　(7)　A380-A380　2004/04

ISSN： 0028-3878
Soluble CD26 and CD30 levels in CSF of patients with relapsing neuromyelitis optica

T Misu, K Fujihara, K Narikawa, Nakashima, I, S Sato, Y Itoyama

NEUROLOGY　62　(7)　A380-A381　2004/04

ISSN： 0028-3878
多発性硬化症及びHAMにおけるCD25high+CD4+制御性T細胞サブセットの解析

馮娟, 三須建郎, 藤原一男, 中島一郎, 佐藤滋, 糸山泰人

神経免疫学　12　(1)　39-39　2004/01
Publisher: 日本神経免疫学会
ISSN： 0918-936X
新規抗ウイルス薬プレコナリルが奏効した無ガンマグロブリン血症を伴った難治性エンテロウイルス髄膜脳炎の一例

三須建郎, 志賀裕正, 佐藤峰成, 加藤昌昭, 武田篤, 土屋滋, 糸山泰人

NEUROINFECTION　9　(2)　87-87　2004
Publisher: 日本神経感染症学会
ISSN： 1348-2718

eISSN： 2435-2225
視神経脊髄型及び通常型多発性硬化症における髄液および血清中の可溶性CD26及びCD30濃度の比較解析

成川孝一, 三須建郎, 藤原一男, 中島一郎, 糸山泰人

神経免疫学　12　(1)　33-33　2004/01
Publisher: 日本神経免疫学会
ISSN： 0918-936X
Vogt-Koyanagi-Harada病における血清および髄液のケモカインの検討

宮澤イザベル, 阿部俊明, 成川孝一, 馮娟, 三須建郎, 中島一郎, 藤盛寿一, 玉井信, 藤原一男, 糸山泰人

神経免疫学　12　(1)　38-38　2004/01
Publisher: 日本神経免疫学会
ISSN： 0918-936X
難治性吃逆と嘔吐を呈した多発性硬化症症例の検討

藤原一男, 三須建郎, 中島一郎, 佐藤滋, 高瀬卓夫, 糸山泰人

臨床神経学　43　(12)　970-970　2003/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
多発性硬化症患者におけるibudilast投与による免疫調整作用の解析

馮娟, 三須建郎, 藤原一男, 佐古田三郎, 中辻裕司, 深浦彦彰, 菊地誠志, 田代邦雄, 錫村明生, 石井直人, 菅村和夫, 中島一郎, 糸山泰人

臨床神経学　43　(12)　1030-1030　2003/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
多発性硬化症髄液中のIgG subclass profileの検討

中島一郎, 藤原一男, 藤盛寿一, 成川孝一, 三須建郎, 佐藤滋, 高瀬貞夫, 糸山泰人

臨床神経学　43　(12)　1033-1033　2003/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X
視神経脊髄型及び通常型多発性硬化症とHAM患者の髄液ケモカイン濃度の比較解析

成川孝一, 三須建郎, 藤原一男, 中島一郎, 馮娟, 糸山泰人

臨床神経学　43　(12)　1033-1033　2003/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
多発性硬化症の脳病巣におけるCCR7及びそのリガンド(CCL19,CCL21)の発現解析

三須建郎, 藤原一男, 小野寺宏, 中島一郎, 馮娟, 藤盛寿一, 佐藤滋, 高瀬貞夫, 義江修, 糸山泰人

臨床神経学　43　(12)　1051-1051　2003/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X
【多発性硬化症最新の基礎・臨床研究】臨床研究の進歩臨床免疫学ケモカイン・ケモカイン受容体の意義

三須建郎, 藤原一男, 糸山泰人

日本臨床　61　(8)　1422-1427　2003/08
Publisher: (株)日本臨床社
ISSN： 0047-1852
[Chemokines and chemokine receptors in multiple sclerosis] (Nippon Rinsho)

Misu Tatsuro, Fujihara Kazuo, Itoyama Yasuto

Nippon Rinsho　61　(8)　1422-1427　2003/08
HAM患者におけるinterferon-α療法前後T,NK,NT及びNKTサブセットの比較解析

馮娟, 三須建郎, 藤原一男, 齋藤博, 志賀裕正, 高瀬貞夫, 糸山泰人

神経治療学　20　(3)　279-279　2003/05
Publisher: (一社)日本神経治療学会
ISSN： 0916-8443

eISSN： 2189-7824
免疫療法の新しい展開多発性硬化症の病態,治療とケモカイン

藤原一男, 三須建郎, 中島一郎, 成川孝一, FENG J, 藤盛寿一, 佐藤滋, 高瀬貞夫, 糸山泰人

Neuroimmunology　11　(2)　2003

ISSN： 0918-936X
Analysis of disease type and immunological pathology of multiple sclerosis.

糸山泰人, 藤原一男, 中島一郎, 三須建郎, 藤盛寿一, 成川孝一, ひょうえん, 佐藤滋, 高瀬貞夫

免疫性神経疾患に関する調査研究平成14年度総括・分担研究報告書　2003
HAMにおけるインターフェロンα(IFNα)療法前後のHTLV-I Proviral DNA量

馮娟, 三須建郎, 藤原一男, 三沢尚子, 小柳義夫, 武田篤, 志賀裕正, 佐藤滋, 高瀬貞男, 鴻巣武, 齋藤博, 糸山泰人

臨床神経学　42　(12)　1316-1316　2002/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
多発性硬化症病巣におけるCCR7陽性抗原提示細胞及びcentral memoryT細胞の解析

三須建郎, 藤原一男, 小野寺宏, 中島一郎, 馮娟, 藤盛寿一, 佐藤滋, 高瀬貞夫, 義江修, 糸山泰人

臨床神経学　42　(12)　1219-1219　2002/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X
本邦の視神経脊髄型多発性硬化症の長期追跡例の検討

藤原一男, 三須建郎, 中島一郎, 宮澤イザベル, 佐藤滋, 高瀬貞夫, 糸山泰人

臨床神経学　42　(12)　1286-1286　2002/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
多発性硬化症のオリゴクローナルバンドと脳梁病変

中島一郎, 藤原一男, 三須建郎, 藤盛寿一, 糸山泰人, 宮澤英充, 佐藤滋, 高瀬貞夫

臨床神経学　42　(12)　1286-1286　2002/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X
日本における多発性硬化症の多様性とその病態視神経脊髄型MSと免疫病態

藤原一男, 中島一郎, 三須建郎, 藤盛寿一, 馮娟, 佐藤滋, 宮澤イザベル, 糸山泰人

臨床神経学　42　(11)　1195-1197　2002/11
Publisher: (一社)日本神経学会
ISSN： 0009-918X
[Pathogenesis of optic-spinal MS].

Kazuo Fujihara, Ichiro Nakashima, Tatsuro Misu, Juichi Fujimori, Juan Feng, Shigeru Sato, Isabelle Miyazawa, Yasuto Itoyama

Rinsho shinkeigaku = Clinical neurology　42　(11)　1195-7　2002/11

ISSN： 0009-918X

More details Close

We reviewed the clinical and immunological features of optic-spinal multiple sclerosis (OSMS), or relapsing neuromyelitis optica. OSMS has collected much attention as to whether it is a distinct entity from conventional MS (CMS). However, OSMS plus minor cerebral and brainstem/cerebellar involvement and the later conversion into CMS had been a diagnostic dilemma. To overcome such problems and delineate the features of OSMS, we analyzed 'Pure OSMS' with which patients had only relapsing optic neuritis and myelitis clinically and consistently normal brain MRI during 5 years or longer follow-ups. As a result, we found that this type of MS was characterized by a definite female preponderance and negative oligoclonal IgG bands (OB), although 'Pure OSMS' was heterogeneous with regards to the clinical severity and HLA class II alleles. Previously reported immunological data in OSMS include negative OB and no elevation of IL-10 or matrix metalloproteinase-9 in the cerebrospinal fluid (CSF) during relapses. In addition, we recently demonstrated that the CCR5+ Th1 cell subset in CSF during relapses, which significantly increased in CMS, remained low in OSMS. These unique clinical and immunological findings probably relate to fundamental differences in the pathogeneses of OSMS and CMS and deserve further characterization.
Immunological and virological effects of interferon-alpha therapy in HTLV-I-associated myelopathy/tropical spastic paraparesis

J Feng, T Misu, K Fujihara, N Misawa, Y Koyanagi, Y Shiga, S Sato, S Takase, T Konosu, H Saito, Y Itoyama

ANNALS OF NEUROLOGY　52　(3)　S72-S72　2002/09

ISSN： 0364-5134
3回の再発を繰り返したギラン・バレー症候群の1例

佐藤滋, 望月るり子, 大沼歩, 野村宏, 高瀬貞夫, 千田圭二, 成川孝一, 三須建郎, 藤原一男, 糸山泰人

臨床神経学　42　(7)　644-644　2002/07
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
CCR7-positive antigen presenting cells and central memory T cells in CNS of multiple sclerosis

T Misu, K Fujihara, H Onodera, Nakashima, I, F Juan, J Fujimori, S Sato, S Takase, O Yoshie, Y Itoyama

NEUROLOGY　58　(7)　A304-A304　2002/04

ISSN： 0028-3878
The association between oligoclonal IgG bands and corpus callosal lesions in Japanese multiple sclerosis patients

Nakashima, I, K Fujihara, T Misu, H Miyazawa, J Fujimori, S Sato, S Takase, Y Itoyama

NEUROLOGY　58　(7)　A71-A71　2002/04

ISSN： 0028-3878
【多発性硬化症】 Neuromyelitis optica(Devic病) 原典とその今日的意義 (神経内科)

藤原一男, 宮澤イザベル, 中島一郎, 三須建郎, 藤盛寿一

神経内科　56　(4)　306-311　2002/04
Publisher: (有)科学評論社
ISSN： 0386-9709
多発性硬化症の脱髄病巣におけるケモカイン及びその受容体の解析 CCR7陽性細胞との関連を中心に

三須建郎, 藤原一男, 小野寺宏, 中島一郎, 藤盛寿一, 佐藤滋, 高瀬貞夫, 義江修, 糸山泰人

Neuroimmunology　10　(1)　2002

ISSN： 0918-936X
GST pull down assayによる多発性硬化症のOligoclonal IgG Band吸着の試み

藤盛寿一, 中島一郎, 藤原一男, 佐々木義輝, 菅村和夫, 三須建郎, 佐藤滋, 山本雅裕, 糸山泰人

Neuroimmunology　10　(1)　2002

ISSN： 0918-936X
多発性硬化症病因・病態研究の進歩と新たな治療法

糸山泰人, 藤原一男, 中島一郎, 三須建郎, 藤盛寿一, 佐藤滋

脳と神経　54　(1)　5-21　2002/01
Publisher: (株)医学書院
DOI： 10.11477/mf.1406901886 　

ISSN： 0006-8969

eISSN： 2185-405X
Multiple sclerosis - Recent advances in pathogenesis and treatment

Yasuto Itoyama, Kazuo Fujihara, Ichiro Nakashima, Takeo Misu, Toshikazu Fujimori

Brain and Nerve　54　(1)　5-21　2002

ISSN： 0006-8969
多発性硬化症の中枢神経系におけるセントラルメモリー細胞の解析

三須建郎, 藤原一男, 小野寺宏, 義江修, 糸山泰人

日本免疫学会総会・学術集会記録　31　311-311　2001/12
Publisher: (NPO)日本免疫学会
ISSN： 0919-1984
HAM患者におけるIFN-α療法前後のリンパ球サブセット,ケモカイン受容体,細胞内サイトカインの比較解析

馮娟, 三須建郎, 藤原一男, 成川孝一, 浅野昌宏, 長谷川隆文, 古川勝敏, 武田篤, 志賀裕正, 佐藤滋

臨床神経学　41　(11)　902-902　2001/11
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
Neuromyelitis opticaの重症度及びステロイド療法に対する反応性の検討

三須建郎, 藤原一男, 中島一郎, 宮澤イザベル, 沖田直, 高瀬貞夫, 糸山泰人

神経治療学　18　(5〜6)　510-510　2001/11
Publisher: 日本神経治療学会
ISSN： 0916-8443

eISSN： 2189-7824
髄内三叉神経根に一致した特異な線状病変を呈する多発性硬化症症例の解析

藤原一男, 中島一郎, 深澤俊行, 佐藤滋, 小川達次, 三須建郎, 金原禎子, 濱田毅, 沖田直, 高瀬貞夫

臨床神経学　41　(11)　867-867　2001/11
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
多発性硬化症患者の末梢血及び髄液におけるNK,NKT,natural T細胞サブセットの検討

三須建郎, 藤原一男, 小野寺宏, 馮娟, 中島一郎, 佐藤滋, 高瀬貞男, 糸山泰人

臨床神経学　41　(11)　923-923　2001/11
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
多発性硬化症(MS)の経過中に変化するT細胞レセプター(TCR)・レパトアの分析

松本陽, 藤原一男, 三須建郎, 中島一郎, 糸山泰人, 佐藤滋

臨床神経学　41　(11)　923-923　2001/11
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
日本人多発性硬化症におけるオリゴクローナルバンド出現頻度

中島一郎, 藤原一男, 藤盛寿一, 三須建郎, 佐藤滋, 高瀬貞夫, 糸山泰人

臨床神経学　41　(11)　997-997　2001/11
Publisher: (一社)日本神経学会
ISSN： 0009-918X
多発性硬化症患者の髄液oligoclonal IgG認識エピトープとウイルスとのアミノ酸配列相同性に関する検討

藤盛寿一, 中島一郎, 藤原一男, 三須建郎, 佐藤滋, 高瀬貞夫, 山本雅裕, 山本直樹, 糸山泰人

臨床神経学　41　(11)　997-997　2001/11
Publisher: (一社)日本神経学会
ISSN： 0009-918X
【視神経脊髄型MS(視神経脊髄型多発性硬化症)】視神経脊髄型MSの疫学と臨床

中島一郎, 藤原一男, 三須建郎, 糸山泰人

脳と神経　53　(10)　911-917　2001/10
Publisher: (株)医学書院
ISSN： 0006-8969

eISSN： 2185-405X
多発性硬化症の治療 (Current Insights in Neurological Science)

糸山泰人, 藤原一男, 中島一郎, 三須建郎, 藤盛寿一, 佐藤滋

Current Insights in Neurological Science　9　(2)　2-4　2001/08
Publisher: (株)マッキャンヘルスケアワールドワイドジャパン
ISSN： 0918-9645
【脊髄 update】主な脊髄疾患の診療の進歩横断性脊髄炎 (Clinical Neuroscience)

三須建郎, 中島一郎, 藤原一男, 糸山泰人

Clinical Neuroscience　19　(7)　788-791　2001/07
Publisher: (株)中外医学社
ISSN： 0289-0585
Pure neuromyelitis optica: A clinical, MRI, and immunological study in 10 Japanese patients

T Misu, K Fujihara, Nakashima, I, Miyazawa, I, N Okita, S Takase, Y Itoyama

NEUROLOGY　56　(8)　A196-A196　2001/04

ISSN： 0028-3878
Clinical features of Japanese multiple sclerosis patients without oligoclonal IgG bands

Nakashima, I, K Fujihara, T Misu, J Fujimori, S Sato, S Takase, Y Itoyama

NEUROLOGY　56　(8)　A197-A197　2001/04

ISSN： 0028-3878
The epitope analysis of CSF oligoclonal IgG in Japanese MS patients by phage display method

J Fujimori, Nakashima, I, K Fujihara, T Misu, S Sato, S Takase, M Yamamoto, N Yamamoto, Y Itoyama

NEUROLOGY　56　(8)　A225-A225　2001/04

ISSN： 0028-3878
多発性硬化症患者の髄液oligoclonal IgG認識エピトープとウイルスとのアミノ酸配列相同性に関する検討

藤盛寿一, 中島一郎, 藤原一男, 三須建郎, 佐藤滋, 高瀬貞夫, 山本雅裕, 山本直樹, 糸山泰人

Neuroimmunology　9　(1)　2001

ISSN： 0918-936X
等電点電気泳動法とアガロースゲル電気泳動法による多発性硬化症のオリゴクローナルバンドの比較検討

中島一郎, 藤原一男, 三須建郎, 藤盛寿一, 佐藤滋, 高瀬貞夫, 糸山泰人

Neuroimmunology　9　(1)　2001

ISSN： 0918-936X
Epidemiology and clinical features of optic-spinal form multiple sclerosis in Japan

I. Nakashima, K. Fujihara, T. Misu, Y. Itoyama

Brain and Nerve　53　(10)　911-917　2001

ISSN： 0006-8969
多発性硬化症患者の末梢血及び髄液におけるリンパ球表面マーカーの検討

三須建郎, 小野寺宏, 藤原一男, 中島一郎, 糸山泰人

臨床神経学　40　(12)　1412-1412　2000/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
多発性硬化症患者の再発時の末梢血及び髄液におけるNK,NKT,natural T細胞の検討

三須建郎, 藤原一男, 小野寺宏, 糸山泰人

日本免疫学会総会・学術集会記録　30　308-308　2000/11
Publisher: (NPO)日本免疫学会
ISSN： 0919-1984
【免疫性神経疾患ここまで進んだ病態解明と治療】日本における多発性硬化症の特徴 (内科)

藤原一男, 中島一郎, 佐久間良, 三須建郎, 小野寺宏, 糸山泰人

内科　85　(4)　728-731　2000/04
Publisher: (株)南江堂
ISSN： 0022-1961

eISSN： 2432-9452
血漿交換とエンドキサンパルスの併用療法が有効であった血清IgM抗GM1抗体陽性下位運動ニューロン病の1例

山川一夫, 三須建郎, 藤森寿一, 千田圭二, 沖田直, 高瀬貞夫

臨床神経学　40　(1)　76-76　2000/01
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
サイアミン静注直後に劇的に覚醒レベルが改善したWernicke-Korsakoff症候群の1例

菊池昭夫, 千田圭二, 三須建郎, 沖田直, 野村宏, 今野秀彦, 高瀬貞夫, 武田篤, 糸山泰人

脳と神経　52　(1)　59-63　2000
Publisher: (株)医学書院
ISSN： 0006-8969

eISSN： 2185-405X
広範な硬膜外髄液貯留を認め髄液漏出部を確認できた原発性低髄液圧症候群の1例

三須建郎, 高橋俊明, 佐藤滋, 竪山真規, 加藤宏之, 糸山泰人

臨床神経学　39　(9)　948-952　1999/09
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
【自己免疫疾患診療の最新知識】多発性硬化症の最新の概念と治療 (臨床成人病)

三須建郎, 藤原一男, 中島一郎, 糸山泰人

臨床成人病　29　(7)　927-932　1999/07
Publisher: (株)東京医学社
ISSN： 0387-1231
心筋障害を主徴としたBecker型筋ジストロフィー症の1例

三須建郎, 小林和夫, 斎藤公男, 館山真規

臨床神経学　39　(6)　678-678　1999/06
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
髄液漏を証明し得た低髄液圧症候群の1例

三須建郎

臨床神経学　38　(4)　361-361　1998/04
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
両側び漫性大脳白質病変を呈した小児期発症の多発性硬化症の一例

三須建郎

臨床神経学　37　(11)　1047-1047　1997/11
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654

Show all ︎Show first 5

Presentations 34

神経・グリアネットワーク障害と神経疾患視神経脊髄炎関連疾患の自己免疫現象に見る神経・グリア連関 Invited

三須建郎

日本神経治療学会　2021/10/28
抗MOG抗体関連疾患の特徴 Invited

三須建郎

日本神経免疫学会　2021/10/21
Joint Meeting with the Japanese Society of Neuroimmunology Immunopathology of NMOSD Invited

Tatsuro Misu

2021/10/22
自己免疫性脳炎の基礎．シンポジウム自己免疫性脳炎と感染症． Invited

三須建郎

日本神経感染症学会　2021/10/01
Systemic autoimmunity vs CNS autoimmunity. Pathological perspective. Invited

Tatsuro Misu

Virtual BCTRIMS 2021 22nd annual meeting　2021/06/10
自己抗体関連疾患に見る腫瘍様脱髄病変の形成機序に関する考察ワークショップ２ Tumefactive demyelinating lesionsの病態について Invited

三須建郎

第62回日本神経病理学会総会　2021/05/29
臨床からみたＭＳとＮＭＯＳＤ Invited

三須建郎

日本神経治療学会　2020/10/30
NMOSDとMOG抗体関連疾患の病理病態と治療 Invited

三須建郎

日本神経治療学会　2020/10/29
MS/NMO治療の最新の動向 Invited

三須建郎

日本神経治療学会　2020/10/28
免疫介在性中枢神経疾患の病態と動物モデルを用いた治療法開発 NMOSDとMOG抗体関連疾患の病理病態と治療 Invited

三須建郎

日本神経治療学会　2020/10/29
NMOSDにおける補体の役割 Invited

三須建郎

日本神経免疫学会　2020/10/01
Molecular pathology of NMOSD. Session 4. Role of pathogenic antibodies. The example of MOG antibody associated IDD. The role of B-lymphocytes in multiple sclerosis. Invited

Tatsuro Misu

The 27th annual meeting of the European Charcot Foundation (Baveno, Itary)　2019/11/22
New insight into the pathogenesis of anti-MOG and other disseminated demyelinating diseases. International-presentation Invited

MISU Tatsuro

World Congress of Neurology　2017/09/16
NMO Immunopathology. International-presentation Invited

MISU Tatsuro

Pan-Asian Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS) 2014　2014/10/07
Pathology of NMO spectrum disorder. International-presentation Invited

MISU Tatsuro

15th Brazilian Committee of Treatment and Research in Multiple Sclerosis (BCTRIMS) 2014　2014/08/08
Pathology of Neuromyelitis optica. International-presentation Invited

MISU Tatsuro

World Congress of Neurology 2013 (Vienna, Austria)　2013/09/22
Pathological features of Aquaporin-4 autoimmunity with cytotoxic edema: the lesson from neuromyelitis optica and related disorders. International-presentation Invited

MISU Tatsuro

ISBRA World Congress　2012/09/10
Pathology of Neuromyelitis optica.

MISU Tatsuro

Sendai Conference 2012　2012/07/14
Spectrum of MS and NMO Part 1. From Pathological studies. Pathology of MS and NMO. International-presentation Invited

MISU Tatsuro

PACTRIMS 2009　2009/11/20
Immunopathology of MS and Implications for Classification: Differences in MS and NMO International-presentation

Tatsuro Misu, M

5th Pan Asian MS Forum Conference　2007/11/01
Loss of Aquaporin 4 in lesions of Neuromyelitis optica: distinction from multiple sclerosis International-presentation

Misu T, Fujihara K, Kakita A, Konno H, Nakamura M, Watanabe T, Takahashi T, Nakashima I, Takahashi H, Itoyama Y

23rd Congress of the European Comittee for Treatment and Research in Multiple Sclerosis　2007/10/11
視神経脊髄炎の病巣におけるアクアポリン４の欠落:多発性硬化症との相違アストロサイトの意義に注目して

三須建郎, 藤原一男, 柿田明美, 高橋均, 糸山泰人

正常圧水頭症と関連疾患の病因・病態と治療に関する研究（厚生労働科学難治性疾患克服研究事業(H17-難治-一般017）　2007/09/25
Loss of Aquaporin 4 in lesions of Neuromyelitis optica: distinction from multiple sclerosis

Misu T, Fujihara K, Kakita A, Konno H, Nakamura M, Watanabe T, Takahashi T, Nakashima I, Takahashi H, Itoyama Y

The 6th MS Workshop in Sapporo　2007/08/04
Loss of Aquaporin 4 in lesions of Neuromyelitis optica: distinction from multiple sclerosis International-presentation

Misu T, Fujihara K, Kakita A, Konno H, Nakamura M, Watanabe T, Takahashi T, Nakashima I, Takahashi H, Itoyama Y

第5回アクアポリン国際会議　2007/07/13
Loss of Aquaporin 4 in lesions of Neuromyelitis optica: distinction from multiple sclerosis

Tatsuro Misu, M

MSカンファレンス　2007/06/19
視神経脊髄炎の病巣におけるアクアポリン４の欠落:多発性硬化症との相違

三須建郎

東北臨床超微形態懇話会　2007/06/06
Loss of Aquaporin 4 in lesions of Neuromyelitis optica: distinction from multiple sclerosis International-presentation

Misu T, Fujihara K, Kakita A, Konno H, Nakamura M, Watanabe T, Takahashi T, Nakashima I, Takahashi H, Itoyama Y

59th Annual meeting of the American Academy of Neurology　2007/04/28
Loss of Aquaporin 4 in lesions of Neuromyelitis optica: distinction from multiple sclerosis

Misu T, Fujihara K, Kakita A, Konno H, Nakamura M, Watanabe T, Takahashi T, Nakashima I, Takahashi H, Itoyama Y

平成19年度生理学研究所研究会『グリア細胞による脳機能調節機構の解明新しいグリアの手がかりを求めて』　2007/04/26
視神経脊髄炎（NMO)の病理学的検討〜アクアポリン4、アストログリアを起因とする疾患群

三須建郎, 藤原一男, 柿田明美, 今野秀彦, 中村正史, 渡辺承平, 高橋利幸, 中島一郎, 高橋均, 糸山泰人

第19回日本神経免疫学会　2007/04/12
抗アクアポリン4抗体とNMO-IgGの比較検討

高橋利幸, 中村正史, 三須建郎, 中島一郎, 藤原一男, 糸山泰人

日本神経免疫学会　2007/04/12
Neuromyelitis opticaの脊髄病巣におけるアクアポリン４の欠落

三須建郎, 糸山泰人, 藤原一男, 中島一郎, 柿田明美, 高橋均

平成18年度厚生労働省神経免疫班会議　2007/01/24
Multiple sclerosis in Asia-Pacific - You believe a patient is a sub-optimal responder to treatment: what is your approach? International-presentation

Misu T, Carroll W

Pan Asian MS Forum　2006/11/03
Loss of Aquaporin 4 in Neuromyelitis optica International-presentation

Misu T

ECTRIMS　2006/09/26
NMOにおけるAquaporin4の発現〜症例報告

三須建郎

MSワークショップ　2006/08/05

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Research Projects 13

特発性正常圧水頭症の認知・精神・行動障害に関連する神経基盤の解明

菅野重範, 三須建郎

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2020/04/01 - 2024/03/31

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2021年度は，東北大学病院高次脳機能障害科に入院された特発性正常圧水頭症患者のうち10名から本研究の参加同意を得た．注意機能，遂行機能，記憶能力を中心に評価する神経心理検査，歩行検査，安静時機能的MRIの撮像，拡散テンソル画像の撮像，脳血流シンチと線条体シンチの撮像，アルツハイマー病に関連する髄液バイオマーカーの測定が全例において施行された．また，研究代表者が作成した特発性正常圧水頭症の3主徴（歩行障害，認知機能障害，排尿障害）の重症度を評価するアンケートが患者とその介護者の全例におてい施行され、3主徴に関する病態失認の重症度を全例で評価することができた。その一方、無為・無関心の評価に関しては、新型コロナウィルス感染の流行により、多くの研究参加者が日常生活での行動の制限を受けてしまったため、評価の継続を断念せざるを得なかった。昨年度の研究参加者を含めた安静時機能的MRI画像のデータを用いて、独立成分分析を施行した結果、研究代表者の先行研究において特発性正常圧水頭症における認知機能（特に注意機能と記憶能力）との強い関連が示されたDefault mode networkと，内受容性の情報に基づいてどの内的・外的情報に最も関心を向けるのかを制御しているとされているSalience network，意図した行為の実行に深く関連するものと推察される左右各々のexecutive networkを、昨年度と同様に全て検出することができた．また，拡散テンソル画像のデータを解析することにより，各患者における大脳白質の構造完全性を測定することもできた．2022年度も2020年度、2021年度と同様に，特発性正常圧水頭症患者から研究参加者を募り，上記のデータの収集を継続する予定である．
Cellular immunnogenesis in MOG antibody related encephalomyelitis

Misu Tatsuro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2019/04 - 2022/03

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In myelin oligodendrocyte glycoprotein (MOG) antibody associated disorders (MOGAD), it was revealed that the pathological features of MOGAD was the dominance of perivenous demyelinating lesions with infiltrations of CD4 positive T cells like acute disseminated encephalomyelitis (ADEM). It was also revealed that the mechanisms of humoral immunity in MOGAD were different from those in neuromyelitis optica spectrum disorders (NMOSD). For cellular immunity in MOGAD, we studied the existence of antigen-specific T cells in MOGAD, which was done by peripheral blood T mononuclear cells were cultured with overlapping peptides of MOG and identified by flowcytometry. We revealed some antigen-specific T cells in MOGAD. These data suggested that both the humoral and cellular immunity were important in the pathogenesis of MOGAD.
進行性多巣性白質脳症：ＪＣウイルス感染が誘導する組織反応と、宿主免疫応答の解明 Competitive

原由紀子

Offer Organization: 文部科学省

System: 科学研究費補助金基盤（C）分担

2018/04 - 2021/03
視神経脊髄炎免疫病態の解明と治療法の開発 Competitive

三須建郎

Offer Organization: 文部科学省

System: 科学研究費補助金基盤（C）

2015/04 - 2018/03
特発性炎症性筋疾患におけるリンフォイドネオジェンシスと自然免疫の分子病態解析 Competitive

竪山真規

Offer Organization: 文部科学省

System: 科学研究費補助金基盤（C）分担

2013/04 - 2016/03
HTLV-1関連脊髄症において新規に同定した病原性ヘルパーCD4+T細胞の解析 Competitive

山野嘉久

Offer Organization: 文部科学省

System: 科学研究費補助金基盤（C）分担

2013/04 - 2016/03
アストロサイト病変モデルにおける二次性脱髄機序の解明 Competitive

三須建郎

Offer Organization: 文部科学省

System: 科学研究費補助金基盤（C）

2012/04 - 2015/03
視神経脊髄炎の新たなアストロサイトパチーの疾患概念の確立と病態、治療に関する研究 Competitive

糸山泰人

Offer Organization: 文部科学省

System: 科学研究費補助金基盤（S）分担

2010/04 - 2015/03
視神経脊髄炎におけるアクアポリン4関連免疫病態の解明 Competitive

三須建郎

Offer Organization: 文部科学省

System: 科学研究費補助金若手（B）

2009/04 - 2011/03
(デビック病)におけるアクアポリン4関連分子及び細胞病態の解明 Competitive

藤原一男

Offer Organization: 文部科学省

System: 科学研究費補助金基盤（B）分担

2008/04 - 2010/03
視神経脊髄型多発性硬化症の病態解明と新たな疾患概念と治療法の確立 Competitive

糸山泰人

Offer Organization: 文部科学省

System: 科学研究費補助金基盤研究（A）分担

2007/04 - 2010/03
多発性硬化症の免疫病態におけるアクアポリン4抗体の意義に関する臨床・病理学的検討 Competitive

三須建郎

Offer Organization: 文部科学省

System: 科学研究費補助金若手（B）

2007/04 - 2009/03
多発性硬化症の中枢神経内における抗原認識機構の解析 Competitive

三須建郎

Offer Organization: 文部科学省

System: 科学研究費若手（B）

2005/04 - 2007/03

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