TOHOKU UNIVERSITY Researchers - Yoshitaka Masutani

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Yoshitaka Masutani

Section

Graduate School of Medicine

Job title

Professor

Degree

博士（医学）（東京大学）
博士（工学）（東京大学）
修士（工学）（東京大学）

researchmap

https://researchmap.jp/y-masutani

J-GLOBAL ID

200901056442366407

Research History 8

2022/09 - Present

Tohoku University　School of Medicine　professor
2014/04 - 2022/08

Hiroshima City University　Graduate School of Information Sciences
2001/12 - 2014/03

The University of Tokyo　Faculty of Medicine University Hospital, Department of Radiology
2000/10 - 2001/12

The University of Tokyo　Graduate School of Frontier Sciences
1998/10 - 2000/09

米国シカゴ大学　大学病院　常任研究員
1997/09 - 1998/09

ドイツハンブルク大学　エッペンドルフ病院医用数学・情報処理研究所　ポスドク研究員
1994/04 - 1997/03

JSPS Research Fellowship for Young Scientist (DC1)
1992/09 - 1993/05

Technical Research Centre of Finland　Hospital Technology Laboratory　visiting researcher

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Education 3

The University of Tokyo　The Graduate School of Engineering　Division of Precision Machinery Engineering Doctor Course

1994/04 - 1997/03
The University of Tokyo　The Graduate School of Engineering　Division of Precision Machinery Master Course

1991/04 - 1994/03
The University of Tokyo　The Faculty of Engineering　Department of Precision Machinery Engineering

1987/04 - 1991/03

Professional Memberships 9

日本応用数理学会
日本コンピュータ外科学会
ISMRM
IEEE
日本医学放射線学会
日本生体医工学会
電子情報通信学会
日本磁気共鳴医学会
日本医用画像工学会

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Awards 11

Distinguished Achievement Award

2022/08　The Japanese Society of Medical Imaging Technology
Scientific Encouragement Award (Conference President's Award)

2021/09　Japanese Society for Magnetic Resonance in Medicine
田中栄一記念賞（MIT誌論文賞）

2014　日本医用画像工学会　遠隔読影環境における多施設連携型CAD開発、実運用、および継続的性能改善.
Magnetic Resonance in Medical Sciences Best Paper Award

2014　Japanese Society for Magnetic Resonance in Medicine　Fast and robust estimation of diffusional kurtosis imaging (DKI) parameters by general closed-form expressions and their extensions.
Summa Cum Laude

2007　American Society of Neuroradiology　Diffusion abnormality in alzheimer disease: tract-specific analysis
第44回エルウィン・フォン・ベルツ賞2等賞

2007　ベーリンガーインゲルハイム社　中枢神経系MRIにおける拡散テンソル解析の基礎と臨床応用：解析ソフトウエアの開発から臨床応用までのトランスレーショナルリサーチ
Certificate of merit

2004/12　Radiological Society of North America (RSNA)　Diffusion tensor tractography of brain tumors: three-dimemensional visualization and implementation to intraoperative navigation system
Certificate of merit

2002/12　Radiological Society of North America (RSNA)　Evaluation of the crossing fiber trajectory through the corpus callosum using diffusion tensor tractography
大会奨励賞

2002　日本医用画像工学会　MR拡散テンソル画像のTractographyにおける拡散異方性に基づくTracking方向決定法の改善
MIT誌論文賞

2002　日本医用画像工学会　MR拡散テンソル画像の解析による脳白質神経線維追跡：追跡の信頼性を考慮した選択的Tractography
Cum Laude

2000/12　Radiological Society of North America (RSNA)　Detection of colonic polyps in CT colonography based on geometric features

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Papers 197

Modeling Liver Fibrosis Progression in Patients With Viral Hepatitis Using the Machine Learning Tool Subtype and Stage Inference (SuStaIn). International-journal

Akiyoshi Suzuki, Katsuhiro Sano, Yuya Saito, Peter Wijeratne, Kotaro Yamamoto, Shohei Fujita, Jun Woo, Nobuo Tomizawa, Koji Kamagata, Hiroshi Imamura, Shuichiro Shiina, Akio Saiura, Kenichi Ikejima, Ryohei Kuwatsuru, Yoshitaka Masutani, Daniel Alexander, Shigeki Aoki

Cureus　17　(2)　e78744　2025/02

DOI： 10.7759/cureus.78744 　

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Background and aim The natural progression of liver fibrosis and its association with biomarker changes have not been fully established in the literature. This study aimed to investigate liver fibrosis progression in patients with hepatitis B virus (HBV) and hepatitis C virus (HCV) infection using a novel machine learning tool called 'Subtype and Stage Inference (SuStaIn).' SuStaIn can identify disease progression patterns and subgroups from cross-sectional biomarker data. Methods This single-center retrospective study included 168 consecutive patients (mean age, 67.0 years ± 13.2; 91 male), comprising 29 with HBV, 50 with HCV, and 89 controls. All patients underwent gadoxetic acid-enhanced magnetic resonance imaging between January 2019 and December 2019. Imaging biomarkers measured were quantitative liver-spleen contrast ratio (Q-LSC), contrast index of liver-muscle signal intensity (CEI), and right liver lobe to the total liver volume ratio (RV/TV), while the serum biomarkers were fibrosis-4 index (FIB-4) and aspartate aminotransferase to platelet ratio index (APRI). SuStaIn was applied using z-scored biomarkers derived from each biomarker relative to the control group. Results The most likely ordering of the biomarker conversion in liver fibrosis progression was determined to be APRI, FIB-4, CEI, Q-LSC, and RV/TV. This sequence was observed to be consistent in all patients infected with either HBV or HCV, regardless of the virus type. Conclusions Using SuStaIn, new insights into liver fibrosis progression in patients infected with either HBV or HCV were achieved: abnormalities in serum biomarkers occurred first, followed by a decrease in hepatic uptake of gadoxetic acid, ultimately resulting in right lobe atrophy.
Recent Advances in Parameter Inference for Diffusion MRI Signal Models.

Yoshitaka Masutani

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine　21　(1)　132-147　2022/03/01

DOI： 10.2463/mrms.rev.2021-0005 　

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In this paper, fundamentals and recent progress for obtaining biological features quantitatively by using diffusion MRI are reviewed. First, a brief description of diffusion MRI history, application, and development was presented. Then, well-known parametric models including diffusion tensor imaging (DTI), diffusional kurtosis imaging (DKI), and neurite orientation dispersion diffusion imaging (NODDI) are introduced with several classifications in various viewpoints with other modeling schemes. In addition, this review covers mathematical generalization and examples of methodologies for the model parameter inference from conventional fitting to recent machine learning approaches, which is called Q-space learning (QSL). Finally, future perspectives on diffusion MRI parameter inference are discussed with the aspects of imaging modeling and simulation.
Advantages of Using Both Voxel- and Surface-based Morphometry in Cortical Morphology Analysis: A Review of Various Applications.

Masami Goto, Osamu Abe, Akifumi Hagiwara, Shohei Fujita, Koji Kamagata, Masaaki Hori, Shigeki Aoki, Takahiro Osada, Seiki Konishi, Yoshitaka Masutani, Hajime Sakamoto, Yasuaki Sakano, Shinsuke Kyogoku, Hiroyuki Daida

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine　21　(1)　41-57　2022/03/01

DOI： 10.2463/mrms.rev.2021-0096 　

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Surface-based morphometry (SBM) is extremely useful for estimating the indices of cortical morphology, such as volume, thickness, area, and gyrification, whereas voxel-based morphometry (VBM) is a typical method of gray matter (GM) volumetry that includes cortex measurement. In cases where SBM is used to estimate cortical morphology, it remains controversial as to whether VBM should be used in addition to estimate GM volume. Therefore, this review has two main goals. First, we summarize the differences between the two methods regarding preprocessing, statistical analysis, and reliability. Second, we review studies that estimate cortical morphological changes using VBM and/or SBM and discuss whether using VBM in conjunction with SBM produces additional values. We found cases in which detection of morphological change in either VBM or SBM was superior, and others that showed equivalent performance between the two methods. Therefore, we concluded that using VBM and SBM together can help researchers and clinicians obtain a better understanding of normal neurobiological processes of the brain. Moreover, the use of both methods may improve the accuracy of the detection of morphological changes when comparing the data of patients and controls.In addition, we introduce two other recent methods as future directions for estimating cortical morphological changes: a multi-modal parcellation method using structural and functional images, and a synthetic segmentation method using multi-contrast images (such as T1- and proton density-weighted images).
Temporal Progression Patterns of Brain Atrophy in Corticobasal Syndrome and Progressive Supranuclear Palsy Revealed by Subtype and Stage Inference (SuStaIn). International-journal

Yuya Saito, Koji Kamagata, Peter A Wijeratne, Christina Andica, Wataru Uchida, Kaito Takabayashi, Shohei Fujita, Toshiaki Akashi, Akihiko Wada, Keigo Shimoji, Masaaki Hori, Yoshitaka Masutani, Daniel C Alexander, Shigeki Aoki

Frontiers in neurology　13　814768-814768　2022

DOI： 10.3389/fneur.2022.814768 　

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Differentiating corticobasal degeneration presenting with corticobasal syndrome (CBD-CBS) from progressive supranuclear palsy with Richardson's syndrome (PSP-RS), particularly in early stages, is often challenging because the neurodegenerative conditions closely overlap in terms of clinical presentation and pathology. Although volumetry using brain magnetic resonance imaging (MRI) has been studied in patients with CBS and PSP-RS, studies assessing the progression of brain atrophy are limited. Therefore, we aimed to reveal the difference in the temporal progression patterns of brain atrophy between patients with CBS and those with PSP-RS purely based on cross-sectional data using Subtype and Stage Inference (SuStaIn)-a novel, unsupervised machine learning technique that integrates clustering and disease progression modeling. We applied SuStaIn to the cross-sectional regional brain volumes of 25 patients with CBS, 39 patients with typical PSP-RS, and 50 healthy controls to estimate the two disease subtypes and trajectories of CBS and PSP-RS, which have distinct atrophy patterns. The progression model and classification accuracy of CBS and PSP-RS were compared with those of previous studies to evaluate the performance of SuStaIn. SuStaIn identified distinct temporal progression patterns of brain atrophy for CBS and PSP-RS, which were largely consistent with previous evidence, with high reproducibility (99.7%) under cross-validation. We classified these diseases with high accuracy (0.875) and sensitivity (0.680 and 1.000, respectively) based on cross-sectional structural brain MRI data; the accuracy was higher than that reported in previous studies. Moreover, SuStaIn stage correctly reflected disease severity without the label of disease stage, such as disease duration. Furthermore, SuStaIn also showed the genialized performance of differentiation and reflection for CBS and PSP-RS. Thus, SuStaIn has potential for improving our understanding of disease mechanisms, accurately stratifying patients, and providing prognoses for patients with CBS and PSP-RS.
Prospective Study of Spatial Distribution of Missed Lung Nodules by Readers in CT Lung Screening Using Computer-assisted Detection. International-journal Peer-reviewed

Soichiro Miki, Yukihiro Nomura, Naoto Hayashi, Shouhei Hanaoka, Eriko Maeda, Takeharu Yoshikawa, Yoshitaka Masutani, Osamu Abe

Academic radiology　28　(5)　647-654　2020/04/15

DOI： 10.1016/j.acra.2020.03.015 　

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PURPOSE: To evaluate the spatial patterns of missed lung nodules in a real-life routine screening environment. MATERIALS AND METHODS: In a screening institute, 4,822 consecutive adults underwent chest CT, and each image set was independently interpreted by two radiologists in three steps: (1) independently interpreted without computer-assisted detection (CAD) software, (2) independently referred to the CAD results, (3) determined by the consensus of the two radiologists. The locations of nodules and the detection performance data were semi-automatically collected using a CAD server integrated into the reporting system. Fisher's exact test was employed for evaluating findings in different lung divisions. Probability maps were drawn to illustrate the spatial distribution of radiologists' missed nodules. RESULTS: Radiologists significantly tended to miss lung nodules in the bilateral hilar divisions (p < 0.01). Some radiologists had their own spatial pattern of missed lung nodules. CONCLUSION: Radiologists tend to miss lung nodules present in the hilar regions significantly more often than in the rest of the lung.
Novel platform for development, training, and validation of computer-assisted detection/diagnosis software. International-journal Peer-reviewed

Yukihiro Nomura, Soichiro Miki, Naoto Hayashi, Shouhei Hanaoka, Issei Sato, Takeharu Yoshikawa, Yoshitaka Masutani, Osamu Abe

International journal of computer assisted radiology and surgery　15　(4)　661-672　2020/04

DOI： 10.1007/s11548-020-02132-z 　

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PURPOSE: To build a novel, open-source, purely web-based platform system to address problems in the development and clinical use of computer-assisted detection/diagnosis (CAD) software. The new platform system will replace the existing system for the development and validation of CAD software, Clinical Infrastructure for Radiologic Computation of United Solutions (CIRCUS). METHODS: In our new system, the two top-level applications visible to users are the web-based image database (CIRCUS DB; database) and the Docker plug-in-based CAD execution platform (CIRCUS CS; clinical server). These applications are built on top of a shared application programming interface server, a three-dimensional image viewer component, and an image repository. RESULTS: We successfully installed our new system into a Linux server at two clinical sites. A total of 1954 cases were registered in CIRCUS DB. We have been utilizing CIRCUS CS with four Docker-based CAD plug-ins. CONCLUSIONS: We have successfully built a new version of the CIRCUS system. Our platform was successfully implemented at two clinical sites, and we plan to publish it as an open-source software project.
Pilot study of eruption forecasting with muography using convolutional neural network. International-journal Peer-reviewed

Yukihiro Nomura, Mitsutaka Nemoto, Naoto Hayashi, Shouhei Hanaoka, Masaki Murata, Takeharu Yoshikawa, Yoshitaka Masutani, Eriko Maeda, Osamu Abe, Hiroyuki K M Tanaka

Scientific reports　10　(1)　5272-5272　2020/03/24

DOI： 10.1038/s41598-020-62342-y 　

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Muography is a novel method of visualizing the internal structures of active volcanoes by using high-energy near-horizontally arriving cosmic muons. The purpose of this study is to show the feasibility of muography to forecast the eruption event with the aid of the convolutional neural network (CNN). In this study, seven daily consecutive muographic images were fed into the CNN to compute the probability of eruptions on the eighth day, and our CNN model was trained by hyperparameter tuning with the Bayesian optimization algorithm. By using the data acquired in Sakurajima volcano, Japan, as an example, the forecasting performance achieved a value of 0.726 for the area under the receiver operating characteristic curve, showing the reasonable correlation between the muographic images and eruption events. Our result suggests that muography has the potential for eruption forecasting of volcanoes.
Managing computer-assisted detection system based on transfer learning with negative transfer inhibition Peer-reviewed

Issei Sato, Soichiro Miki, Yukihiro Nomura, Naoto Hayashi, Yoshitaka Masutani, Shouhei Hanaoka, Osamu Abe

Proceedings of the ACM SIGKDD International Conference on Knowledge Discovery and Data Mining　695-704　2018/07/19

DOI： 10.1145/3219819.3219868 　
Cone-beam CT reconstruction for non-periodic organ motion using time-ordered chain graph model

Masahiro Nakano, Akihiro Haga, Jun'ichi Kotoku, Taiki Magome, Yoshitaka Masutani, Shouhei Hanaoka, Satoshi Kida, Keiichi Nakagawa

RADIATION ONCOLOGY　12　2017/09

DOI： 10.1186/s13014-017-0879-8 　

eISSN： 1748-717X
Understanding Medical Images Based on Computational Anatomy Models Peer-reviewed

Shouhei Hanaoka, Naoki Kamiya, Yoshinobu Sato, Kensaku Mori, Hiroshi Fukuda, Yasuyuki Taki, Kazunori Sato, Kai Wu, Yoshitaka Masutani, Takeshi Hara, Chisako Muramatsu, Akinobu Shimizu, Mikio Matsuhiro, Yoshiki Kawata, Noboru Niki, Daisuke Fukuoka, Tomoko Matsubara, Hidenobu Suzuki, Ryo Haraguchi, Toshizo Katsuda, Takayuki Kitasaka

Computational Anatomy Based on Whole Body Imaging: Basic Principles of Computer-Assisted Diagnosis and Therapy　151-284　2017/06/14
Publisher: Springer Japan
DOI： 10.1007/978-4-431-55976-4_3 　
Alterations of the optic pathway between unilateral and bilateral optic nerve damage in multiple sclerosis as revealed by the combined use of advanced diffusion kurtosis imaging and visual evoked potentials. International-journal

Mariko Yoshida Takemura, Masaaki Hori, Kazumasa Yokoyama, Nozomi Hamasaki, Michimasa Suzuki, Koji Kamagata, Kouhei Kamiya, Yuriko Suzuki, Shinsuke Kyogoku, Yoshitaka Masutani, Nobutaka Hattori, Shigeki Aoki

Magnetic resonance imaging　39　24-30　2017/06

DOI： 10.1016/j.mri.2016.04.011 　

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OBJECTIVES: We investigated changes in the optic tract and optic radiation in patients with multiple sclerosis (MS) by comparing unilateral and bilateral optic nerve damage assessed based on visual evoked potentials (VEPs) using advanced diffusion MR metrics. METHODS: In 21 MS patients, diffusion MRI was performed. Maps of fractional anisotropy, apparent diffusion coefficient (ADC), and mean kurtosis (MK) were computed. On the basis of the P100 latency in VEPs, the MS patients were divided into three groups: bilateral (n=7), unilateral (n=7), and no abnormality (n=7). Their optic tracts and optic radiations were analyzed with diffusion MRI-based fiber tracking. We also investigated the correlations between diffusion parameters and VEPs (n=21). RESULTS: In the optic tract, the diffusion changes in each of the three groups showed step-like changes. The diffusion changes in the optic radiations of the unilateral group were similar to those in the normal VEP group. Only the bilateral group showed significantly higher ADC and lower MK relative to the other two groups (P<0.05, Steel-Dwass multiple-comparison test). A significant positive correlation between VEP latency and ADC and a significant negative correlation between VEP latency and MK were observed (P<0.01, Spearman's correction). CONCLUSIONS: We first evaluated the relationship between VEPs and DKI and concluded that the lateral geniculate nucleus may compensate for unilateral damage in the pre-geniculate optic pathway via neural plasticity.
Automatic detection of vertebral number abnormalities in body CT images Peer-reviewed

Shouhei Hanaoka, Yoshiyasu Nakano, Mitsutaka Nemoto, Yukihiro Nomura, Tomomi Takenaga, Soichiro Miki, Takeharu Yoshikawa, Naoto Hayashi, Yoshitaka Masutani, Akinobu Shimizu

INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY　12　(5)　719-732　2017/06

DOI： 10.1007/s11548-016-1516-y 　

ISSN： 1861-6410

eISSN： 1861-6429
Landmark-guided diffeomorphic demons algorithm and its application to automatic segmentation of the whole spine and pelvis in CT images Peer-reviewed

Shouhei Hanaoka, Yoshitaka Masutani, Mitsutaka Nemoto, Yukihiro Nomura, Soichiro Miki, Takeharu Yoshikawa, Naoto Hayashi, Kuni Ohtomo, Akinobu Shimizu

INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY　12　(3)　413-430　2017/03

DOI： 10.1007/s11548-016-1507-z 　

ISSN： 1861-6410

eISSN： 1861-6429
Automatic detection of over 100 anatomical landmarks in medical CT images: A framework with independent detectors and combinatorial optimization Peer-reviewed

Shouhei Hanaoka, Akinobu Shimizu, Mitsutaka Nemoto, Yukihiro Nomura, Soichiro Miki, Takeharu Yoshikawa, Naoto Hayashi, Kuni Ohtomo, Yoshitaka Masutani

MEDICAL IMAGE ANALYSIS　35　192-214　2017/01

DOI： 10.1016/j.media.2016.04.001 　

ISSN： 1361-8415

eISSN： 1361-8423
Computer-Assisted Detection of Cerebral Aneurysms in MR Angiography in a Routine Image-Reading Environment: Effects on Diagnosis by Radiologists Peer-reviewed

S. Miki, N. Hayashi, Y. Masutani, Y. Nomura, T. Yoshikawa, S. Hanaoka, M. Nemoto, K. Ohtomo

AMERICAN JOURNAL OF NEURORADIOLOGY　37　(6)　1038-1043　2016/06

DOI： 10.3174/ajnr.A4671 　

ISSN： 0195-6108

eISSN： 1936-959X
Machine Learning for Computer-aided Diagnosis Invited

根本充貴, 増谷佳孝, 野村行弘, 花岡昇平, 三木聡一郎, 吉川健啓, 林直人, 大友邦

医学物理　36　(1)　29‐34-34　2016/05
Publisher: 一般社団法人日本医学物理学会
DOI： 10.11323/jjmp.36.1_29 　

ISSN： 1345-5354

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Machine learning algorithms are to analyze any dataset to extract data-driven model, prediction rule, or decision rule from the dataset. Various machine learning algorithms are now used to develop high-performance medical image processing systems such as computer-aided detection (CADe) system which detects clinically significant objects from medical images and computer-aided diagnosis (CADx) system which quantifies malignancy of manually or automatically detected clinical objects. In this paper, we introduce some applications of machine learning algorithms to the development of medical image processing system.
Time Course of Diffusion Kurtosis in Cerebral Infarctions of Transient Middle Cerebral Artery Occlusion Rat Model Peer-reviewed

Toshiaki Taoka, Masayuki Fujioka, Yuto Kashiwagi, Atsushi Obata, Takemi Rokugawa, Masaaki Hori, Yoshitaka Masutani, Shigeki Aoki, Shinji Naganawa, Kohji Abe

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　25　(3)　610-617　2016/03

DOI： 10.1016/j.jstrokecerebrovasdis.2015.11.028 　

ISSN： 1052-3057

eISSN： 1532-8511
Mathematical Foundations and Applications of Diffusion MRI Analysis

MASUTANI Yoshitaka

Medical Imaging and Information Sciences　33　(2)　22-27　2016
Publisher: MEDICAL IMAGING AND INFORMATION SCIENCES
DOI： 10.11318/mii.33.22 　

ISSN： 1880-4977

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In this paper, various signal models of diffusion MRI are introduced with mathematical foundations and applications to provide comprehensive review for researches of diffusion MRI analysis.
Step up MRI 2015 IV 臨床応用に向けた技術開発の現状と展望 3.大量の臨床画像データの活用における問題―4万例を超える臨床画像データの処理を行ったCADシステムの開発・運用経験から Invited

増谷佳孝, 野村行弘, 三木総一郎, 根本充貴, 花岡昇平, 吉川健啓, 林直人

Innervision　30　(9)　35-37　2015/08

ISSN： 0913-8919
逐次最適化散乱補正アルゴリズムを用いたkilo-voltage cone beam CTの画質改善 Peer-reviewed

木田智士, 増谷佳孝, 中野正寛, 今江禄一, 中川恵一, 芳賀昭弘

MEDICAL IMAGING TECHNOLOGY　33　(3)　133-141　2015/05
Publisher: 日本医用画像工学会
ISSN： 0288-450X
HoTPiG: A Novel Geometrical Feature for Vessel Morphometry and Its Application to Cerebral Aneurysm Detection

Shouhei Hanaoka, Yukihiro Nomura, Mitsutaka Nemoto, Soichiro Miki, Takeharu Yoshikawa, Naoto Hayashi, Kuni Ohtomo, Yoshitaka Masutani, Akinobu Shimizu

MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2015, PT II　9350　103-110　2015

DOI： 10.1007/978-3-319-24571-3_13 　

ISSN： 0302-9743

eISSN： 1611-3349
Report on MICCAI 2014

Kitasaka Takayuki, Nakagomi Keita, Otomaru Itaru, Oda Masahiro, Hirano Yasushi, Masutani Yoshitaka, Kim Hyoungseop

IEICE technical report.　114　(311)　49-54　2014/11/18
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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In this paper, the outline of each session of MICCAI 2014 main conference is introduced. A few interesting reports in the conference are also introduced and explained.
Reconstruction of the treatment area by use of sinogram in helical tomotherapy

Akihiro Haga, Keiichi Nakagawa, Calvin Maurer, Ken Ruchala, Edward Chao, Dylan Casey, Satoshi Kida, Dousatsu Sakata, Masahiro Nakano, Taiki Magome, Yoshitaka Masutani

RADIATION ONCOLOGY　9　2014/11

DOI： 10.1186/s13014-014-0252-0 　

eISSN： 1748-717X
Lung tumor motion reproducibility for five patients who received four-fraction VMAT stereotactic ablative body radiotherapy under constrained breathing conditions: a preliminary study. International-journal

Keiichi Nakagawa, Akihiro Haga, Katsutake Sasaki, Satoshi Kida, Yoshitaka Masutani, Hideomi Yamashita, Wataru Takahashi, Hiroshi Igaki, Akira Sakumi, Kuni Ohtomo, Kiyoshi Yoda

Journal of radiation research　55　(6)　1199-201　2014/11

DOI： 10.1093/jrr/rru055 　
Non-Gaussian Diffusion-Weighted Imaging for Assessing Diurnal Changes in Intervertebral Disc Microstructure Peer-reviewed

Masaki Katsura, Yuichi Suzuki, Junichi Hata, Masaaki Hori, Hiroki Sasaki, Hiroyuki Akai, Harushi Mori, Akira Kunimatsu, Yoshitaka Masutani, Shigeki Aoki, Kuni Ohtomo

JOURNAL OF MAGNETIC RESONANCE IMAGING　40　(5)　1208-1214　2014/11

DOI： 10.1002/jmri.24459 　

ISSN： 1053-1807

eISSN： 1522-2586
Performance improvement in computerized detection of cerebral aneurysms by retraining classifier using feedback data collected in routine reading environment. Peer-reviewed

Nomura Y, Masutani Y, Miki S, Nemoto M, Hanaoka S, Yoshikawa T, Hayashi N, Ohtomo K

Journal of Biomedical Graphics and Computing　4　(4)　12-21　2014/09

DOI： 10.5430/jbgc.v4n4p12 　

ISSN： 1925-4016
Corticospinal tract-sparing intensity-modulated radiotherapy treatment planning. International-journal

Hiroshi Igaki, Akira Sakumi, Akitake Mukasa, Kuniaki Saito, Akira Kunimatsu, Yoshitaka Masutani, Shunya Hanakita, Kenji Ino, Akihiro Haga, Keiichi Nakagawa, Kuni Ohtomo

Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology　19　(5)　310-6　2014/09

DOI： 10.1016/j.rpor.2014.01.002 　

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AIM: To establish intensity-modulated radiotherapy (IMRT) planning procedures that spare the corticospinal tract by integrating diffusion tensor tractography into the treatment planning software. BACKGROUND: Organs at risk are generally contoured according to the outline of the organ as demonstrated by CT or MRI. But a part of the organ with specific function is difficult to protect, because such functional part of the organ cannot be delineated on CT or conventional sequence of MRI. METHODS: Diagnostic and treatment planning images of glioblastoma patients who had been treated by conventional 3-dimensional conformal radiotherapy were used for re-planning of IMRT. Three-dimensional fiber maps of the corticospinal tracts were created from the diffusion tensors obtained from the patients before the surgery, and were blended with the anatomical MR images (i.e. gadolinium-enhanced T1-weighted images or T2-weighted images). DICOM-formatted blended images were transferred and fused to the planning CT images. Then, IMRT plans were attempted. RESULTS: The corticospinal tracts could be contoured as organs at risk (OARs), because the blended images contained both anatomical information and fiber-tract maps. Other OARs were contoured in a way similar to that of ordinary IMRT planning. Gross tumor volumes, clinical target volumes, planning target volumes, and other OARs were contoured on the treatment planning software, and IMRT plans were made. CONCLUSIONS: IMRT plans with diminished doses to the corticospinal tract were attained. This technique enabled us to spare specific neuron fibers as OARs which were formerly "invisible" and to reduce the probability of late morbidities.
Reduction of false positives at vessel bifurcations in computerized detection of lung nodules. Peer-reviewed

Nomura Y, Nemoto M, Masutani Y, Hanaoka S, Yoshikawa T, Miki S, Maeda E, Hayashi N, Yoshioka N, Ohtomo K

Journal of Biomedical Graphics and Computing　4　(3)　36-46　2014/07

DOI： 10.5430/jbgc.v4n3p36 　

ISSN： 1925-4016
画素識別器の再学習による頭部MRA画像の脳動脈瘤自動検出の性能改善 Peer-reviewed

野村行弘, 増谷佳孝, 根本充貴, 花岡昇平, 三木聡一郎, 吉川健啓, 林直人, 大友邦

MEDICAL IMAGING TECHNOLOGY　32　(Suppl.)　1-7　2014/07
Publisher: 日本医用画像工学会
ISSN： 0288-450X
Multiple sclerosis: Benefits of q-space imaging in evaluation of normal-appearing and periplaque white matter Peer-reviewed

Masaaki Hori, Mariko Yoshida, Kazumasa Yokoyama, Koji Kamagata, Fumitaka Kumagai, Issei Fukunaga, Kouhei Kamiya, Michimasa Suzuki, Yoshitaka Masutani, Nozomi Hamasaki, Yuriko Suzuki, Shinsuke Kyogoku, Nobutaka Hattori, Shigeki Aoki

MAGNETIC RESONANCE IMAGING　32　(6)　625-629　2014/07

DOI： 10.1016/j.mri.2014.02.024 　

ISSN： 0730-725X

eISSN： 1873-5894
Cervical spondylosis: Evaluation of microstructural changes in spinal cord white matter and gray matter by diffusional kurtosis imaging Peer-reviewed

Masaaki Hori, Satoshi Tsutsumi, Yukimasa Yasumoto, Masanori Ito, Michimasa Suzuki, Fumine S. Tanaka, Shinsuke Kyogoku, Masanobu Nakamura, Takashi Tabuchi, Issei Fukunaga, Yuriko Suzuki, Koji Kamagata, Yoshitaka Masutani, Shigeki Aoki

MAGNETIC RESONANCE IMAGING　32　(5)　428-432　2014/06

DOI： 10.1016/j.mri.2014.01.018 　

ISSN： 0730-725X

eISSN： 1873-5894
Development, Clinical Use, Continuous Performance Improvement of CAD Software Based on Multi-institutional Collaboration in Teleradiology Environment Peer-reviewed

NOMURA Yukihiro, MASUTANI Yoshitaka, MIKI Soichiro, HANAOKA Shouhei, NEMOTO Mitsutaka, YOSHIKAWA Takeharu, HAYASHI Naoto, OHTOMO Kuni

Medical Imaging Technology　32　(2)　98-108　2014/03
Publisher: 日本医用画像工学会
ISSN： 0288-450X

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The performance of computer-assisted detection (CAD) software depends on the quality and quantity of the dataset used for supervised learning. If the data characteristics differ in development and practical use, the performance of CAD software will be degraded. Therefore, it is necessary to continuously collect data for supervised learning in practical use, and to improve CAD software by retraining with the collected data. In this paper, we describe the development, clinical use, and continuous performance improvement of CAD software based on multi-institutional collaboration in teleradiology environment. We developed additional functions of the web-based CAD software processing and evaluation platform (CIRCUS CS) for implementing into teleradiology environment, and a multi-institutional study has been started since September 2011. We investigated the performance improvement of CAD software for each institution based on retraining through a simulation-based study. According to the results, the performance of CAD software for each institution was improved by retraining. These results suggest that the multi-institutional data collection has potential to accelerate development and clinical use of CAD software for various institutions.
Erratum：Development, Clinical Use, Continuous Performance Improvement of CAD Software Based on Multi-institutional Collaboration in Teleradiology Environment[MEDICAL IMAGING TECHNOLOGY No.32 Vol. 2 pp98-108]

NOMURA Yukihiro, MASUTANI Yoshitaka, MIKI Soichiro, HANAOKA Shouhei, NEMOTO Mitsutaka, YOSHIKAWA Takeharu, HAYASHI Naoto, OHTOMO Kuni

Medical Imaging Technology　32　(3)　235-235　2014
Publisher: The Japanese Society of Medical Imaging Technology
DOI： 10.11409/mit.32.235 　

ISSN： 0288-450X

eISSN： 2185-3193
Fast and Robust Estimation of Diffusional Kurtosis Imaging (DKI) Parameters by General Closed-form Expressions and their Extensions

MASUTANI Yoshitaka, AOKI Shigeki

MRMS　13　(2)　97-115　2014
Publisher: Japanese Society for Magnetic Resonance in Medicine
DOI： 10.2463/mrms.2013-0084 　

ISSN： 1347-3182

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Diffusional kurtosis imaging (DKI) for clinical imaging involves time-consuming computation and demonstrates low robustness. Standard estimation of DKI parameters is based on an extension of Stejskal-Tanner's signal model with squared b-value term and is a least-squares fitting problem. The use of numerical methods for computation requires time, and estimation of DKI parameters is noise sensitive and often produces noisy results, such as images with pepper noise.In this study, we propose general closed-form solutions for DKI parameters to avoid numerical computation for least-squares fitting, solutions that can be applied to diffusion weighted imaging (DWI) datasets with any number of b-values more than three. Solutions are obtained through stationary-point conditions of an objective function that are minimized for fitting. We use 3 techniques to extend the solutions to increase robustness—b-value-dependent weighting in fitting, removal of outliers, and addition of neighbor sampling. Based on synthetic datasets and clinical datasets that both consist of 6 b-value and 3 b-value datasets, we detail and compare the 3 methods including a method by Jensen et al. are compared and investigated in detail. The synthetic data consist of several combinations of DKI parameters and some Rician noise. In addition to visually assessing result images, we also performed quantitative evaluation using a range of estimated parameters, positive-definiteness of the objective function for fitting, and root-mean-square error including estimation bias from the true value (synthetic data only). Methods that added neighbor sampling outperformed others in terms of low errors and visual smoothness. Though the solution by our methodis to estimate DKI parameters in a single MPG direction, it can contribute to anisotropic analysis of diffusional kurtosis such as kurtosis tensor. More robust estimation is expected by combining techniques.
Development of automatic visceral fat volume calculation software for CT volume data. International-journal Peer-reviewed

Mitsutaka Nemoto, Tusufuhan Yeernuer, Yoshitaka Masutani, Yukihiro Nomura, Shouhei Hanaoka, Soichiro Miki, Takeharu Yoshikawa, Naoto Hayashi, Kuni Ohtomo

Journal of obesity　2014　495084-495084　2014

DOI： 10.1155/2014/495084 　

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OBJECTIVE: To develop automatic visceral fat volume calculation software for computed tomography (CT) volume data and to evaluate its feasibility. METHODS: A total of 24 sets of whole-body CT volume data and anthropometric measurements were obtained, with three sets for each of four BMI categories (under 20, 20 to 25, 25 to 30, and over 30) in both sexes. True visceral fat volumes were defined on the basis of manual segmentation of the whole-body CT volume data by an experienced radiologist. Software to automatically calculate visceral fat volumes was developed using a region segmentation technique based on morphological analysis with CT value threshold. Automatically calculated visceral fat volumes were evaluated in terms of the correlation coefficient with the true volumes and the error relative to the true volume. RESULTS: Automatic visceral fat volume calculation results of all 24 data sets were obtained successfully and the average calculation time was 252.7 seconds/case. The correlation coefficients between the true visceral fat volume and the automatically calculated visceral fat volume were over 0.999. CONCLUSIONS: The newly developed software is feasible for calculating visceral fat volumes in a reasonable time and was proved to have high accuracy.
Automatic Extraction of the Cingulum Bundle in Diffusion Tensor Tract-specific Analysis: Feasibility Study in Parkinson's Disease with and without Dementia

ITO Kenji, MASUTANI Yoshitaka, KAMAGATA Koji, YASMIN Hasina, SUZUKI Yuichi, INO Kenji, AOKI Shigeki, KUNIMATSU Akira, OHTOMO Kuni

MRMS　12　(3)　201-213　2013/09/01
Publisher: Japanese Society for Magnetic Resonance in Medicine
DOI： 10.2463/mrms.2012-0064 　

ISSN： 1347-3182

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Purpose: Tract-specific analysis (TSA) measures diffusion parameters along a specific fiber that has been extracted by fiber tracking using manual regions of interest (ROIs), but TSA is limited by its requirement for manual operation, poor reproducibility, and high time consumption. We aimed to develop a fully automated extraction method for the cingulum bundle (CB) and to apply the method to TSA in neurobehavioral disorders such as Parkinson's disease (PD). Materials and Methods: We introduce the voxel classification (VC) and auto diffusion tensor fiber-tracking (AFT) methods of extraction. The VC method directly extracts the CB, skipping the fiber-tracking step, whereas the AFT method uses fiber tracking from automatically selected ROIs. We compared the results of VC and AFT to those obtained by manual diffusion tensor fiber tracking (MFT) performed by 3 operators. We quantified the Jaccard similarity index among the 3 methods in data from 20 subjects (10 normal controls [NC] and 10 patients with Parkinson's disease dementia [PDD]). We used all 3 extraction methods (VC, AFT, and MFT) to calculate the fractional anisotropy (FA) values of the anterior and posterior CB for 15 NC subjects, 15 with PD, and 15 with PDD. Results: The Jaccard index between results of AFT and MFT, 0.72, was similar to the inter-operator Jaccard index of MFT. However, the Jaccard indices between VC and MFT and between VC and AFT were lower. Consequently, the VC method classified among 3 different groups (NC, PD, and PDD), whereas the others classified only 2 different groups (NC, PD or PDD). Conclusion: For TSA in Parkinson's disease, the VC method can be more useful than the AFT and MFT methods for extracting the CB. In addition, the results of patient data analysis suggest that a reduction of FA in the posterior CB may represent a useful biological index for monitoring PD and PDD.
複数画素サイズのデータを用いた画素識別処理による頭部MRA画像の脳動脈瘤自動検出 Peer-reviewed

野村行弘, 増谷佳孝, 根本充貴, 花岡昇平, 三木聡一郎, 吉川健啓, 林直人, 大友邦

MEDICAL IMAGING TECHNOLOGY　31　(Suppl.)　1-7　2013/08
Publisher: 日本医用画像工学会
ISSN： 0288-450X
自動検出された解剖学的ランドマークの位置調整手法に関する検討 Pictorial structureによるランドマークのモデル化とその適用 Peer-reviewed

根本充貴, 増谷佳孝, 花岡昇平, 野村行弘, 三木聡一郎, 吉川健啓, 林直人, 大友邦

MEDICAL IMAGING TECHNOLOGY　31　(Suppl.)　1-10　2013/08
Publisher: 日本医用画像工学会
ISSN： 0288-450X
cross validation法による変数選択アルゴリズムを用いたランドマーク局所アピアランスモデルの関心領域形状および画素値ウィンドウの最適化 Peer-reviewed

花岡昇平, 増谷佳孝, 根本充貴, 野村行弘, 三木聡一郎, 吉川健啓, 林直人, 大友邦

MEDICAL IMAGING TECHNOLOGY　31　(Suppl.)　1-10　2013/08
Publisher: 日本医用画像工学会
ISSN： 0288-450X
Microstructural changes of the corticospinal tract in idiopathic normal pressure hydrocephalus: a comparison of diffusion tensor and diffusional kurtosis imaging Peer-reviewed

Atsushi Nakanishi, Issei Fukunaga, Masaaki Hori, Yoshitaka Masutani, Hattori Takaaki, Masakazu Miyajima, Shigeki Aoki

NEURORADIOLOGY　55　(8)　971-976　2013/08

DOI： 10.1007/s00234-013-1201-6 　

ISSN： 0028-3940
Verification of Planning Target Volume Settings in Volumetric Modulated Arc Therapy for Stereotactic Body Radiation Therapy by Using In-Treatment 4-Dimensional Cone Beam Computed Tomography

Wataru Takahashi, Hideomi Yamashita, Satoshi Kida, Yoshitaka Masutani, Akira Sakumi, Kuni Ohtomo, Keiichi Nakagawa, Akihiro Haga

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS　86　(3)　426-431　2013/07

DOI： 10.1016/j.ijrobp.2013.02.019 　

ISSN： 0360-3016

eISSN： 1879-355X
Effects of diffusional kurtosis imaging parameters on diffusion quantification. Peer-reviewed

Issei Fukunaga, Masaaki Hori, Yoshitaka Masutani, Nozomi Hamasaki, Shuji Sato, Yuriko Suzuki, Fumitaka Kumagai, Masatsugu Kosuge, Haruyoshi Hoshito, Koji Kamagata, Keigo Shimoji, Atsushi Nakanishi, Shigeki Aoki, Atsushi Senoo

Radiological physics and technology　6　(2)　343-8　2013/07

DOI： 10.1007/s12194-013-0206-5 　

ISSN： 1865-0333

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Diffusional kurtosis imaging (DKI) is a new technique based on non-Gaussian water diffusion analysis. However, the original DKI protocol (six b values and 30 motion-probing gradient (MPG) directions) requires more than 10 min of scanning time, which is too long for daily clinical use. We aimed to find suitable b value, MPG direction, and diffusion time settings for faster DKI. Four normal healthy subjects participated in the study. All DKI data sets were acquired on a clinical 3T-MRI scanner (Philips Medical Systems) with use of three protocols of 0-7500 s/mm(2) b values, 6-32 MPG directions, and 23-80 ms diffusion time. There was a remarkable difference in the standard deviation (SD) of the mean DK values in the number of MPG directions. The mean DK values were significantly higher in the posterior limb of the internal capsule (p = 0.003, r = 0.924) and thalamus (p = 0.005, r = 0.903), whereas the mean DK values of the cerebrospinal fluid (CSF) (p = 0.001, r = -0.976) were significantly lower when we used a longer diffusion time. Our results indicate that the SD of the mean DK values was higher in 15 MPG directions than in 20 MPG directions and more. Because the mean DK values of the CSF were significantly lower when we used longer diffusion times, we expect longer diffusion times to be useful for DKI. We propose the following imaging parameters for clinical use: 0, 1000, and 2000 s/mm(2) b values; 20 MPG directions; Δ/δ 45.3/13.3 ms.
SU‐E‐J‐122: Time‐Ordered Four Dimensional Cone‐Beam CT

M. Nakano, S. Kida, Y. Masutani, T. Shiraki, K. Shiraishi, K. Yamamoto, K. Nakagawa, A. Haga

Medical Physics　40　(6)　178　2013/06

DOI： 10.1118/1.4814334 　

ISSN： 0094-2405
Performance Improvement in Anatomical Landmark Detection by a New Parameter Optimization Technique : Parameterization of Labeling Criterion for a Training Samples and Use of Novel Evaluation Function

NEMOTO Mitsutaka, MASUTANI Yoshitaka, HANAOKA Shouhei, NOMURA Yukihiro, MIKI Soichiro, YOSHIKAWA Takeharu, HAYASHI Naoto, OHTOMO Kuni

The IEICE transactions on information and systems (Japanese edetion)　96　(4)　853-865　2013/04
Publisher: 一般社団法人電子情報通信学会
ISSN： 1880-4535

eISSN： 1881-0225
SU‐C‐141‐06: Registration Accuracy with Four‐Dimensional Cone‐Beam CT for Lung Cancer Treatment Peer-reviewed

A. Haga, J. Kotoku, S. Kida, Y. Masutani, H. Yamashita, W. Takahashi, T. Imae, K. Nakagawa

Medical Physics　40　(6)　92-93　2013

DOI： 10.1118/1.4813966 　

ISSN： 0094-2405
SU‐E‐I‐14: Improvement of Four Dimensional Cone Beam CT Image Quality with Iterative Reconstruction Peer-reviewed

S. Kida, M. Nakano, Y. Masutani, K. Nakagawa, A. Haga

Medical Physics　40　(6)　128-128　2013

DOI： 10.1118/1.4814122 　

ISSN： 0094-2405
4D registration and 4D verification of lung tumor position for stereotactic volumetric modulated arc therapy using respiratory-correlated cone-beam CT Peer-reviewed

Keiichi Nakagawa, Akihiro Haga, Satoshi Kida, Yoshitaka Masutani, Hideomi Yamashita, Wataru Takahashi, Akira Sakumi, Naoya Saotome, Takashi Shiraki, Kuni Ohtomo, Yoshio Iwai, Kiyoshi Yoda

Journal of Radiation Research　54　(1)　152-156　2013/01

DOI： 10.1093/jrr/rrs058 　

ISSN： 0449-3060 1349-9157
A multiple anatomical landmark detection system for body CT images

Shouhei Hanaoka, Yoshitaka Masutani, Mitsutaka Nemoto, Yukihiro Nomura, Soichiro Miki, Takeharu Yoshikawa, Naoto Hayashi, Kuni Ohtomo

2013 FIRST INTERNATIONAL SYMPOSIUM ON COMPUTING AND NETWORKING (CANDAR)　308-311　2013

DOI： 10.1109/CANDAR.2013.54 　
Post-processing of anatomical landmark detection Distance error reduction by pictorial structure matching-based method

Mitsutaka Nemoto, Yoshitaka Masutani, Syouhei Hanaoka, Yukihiro Nomura, Kuni Ohtomo, Soichiro Miki, Takeharu Yoshikawa, Naoto Hayashi

2013 FIRST INTERNATIONAL SYMPOSIUM ON COMPUTING AND NETWORKING (CANDAR)　316-319　2013

DOI： 10.1109/CANDAR.2013.56 　
Variational method for computing average images of biological organs Peer-reviewed

Shun Inagaki, Atsushi Imiya, Hidekata Hontani, Shouhei Hanaoka, Yoshitaka Masutani

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)　7893　440-451　2013

DOI： 10.1007/978-3-642-38267-3_37 　

ISSN： 0302-9743 1611-3349
Diffusional kurtosis imaging of normal-appearing white matter in multiple sclerosis: preliminary clinical experience Peer-reviewed

Mariko Yoshida, Masaaki Hori, Kazumasa Yokoyama, Issa Fukunaga, Michimasa Suzuki, Koji Kamagata, Keigo Shimoji, Atsushi Nakanishi, Nobutaka Hattori, Yoshitaka Masutani, Shigeki Aoki

JAPANESE JOURNAL OF RADIOLOGY　31　(1)　50-55　2013/01

DOI： 10.1007/s11604-012-0147-7 　

ISSN： 1867-1071
Mathematical Models for Anatomical Landmarks and Point Distribution Representation of Anatomical Objects for Medical Image Understanding

MASUTANI Yoshitaka, HONTANI Hidekata, IMIYA Atsushi

Med Imag Tech　31　(5)　263-269　2013
Publisher: The Japanese Society of Medical Imaging Technology
DOI： 10.11409/mit.31.263 　

ISSN： 0288-450X

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One of the important purposes of the new discipline "Computational Anatomy" is robust computational understanding of clinical images. For the purpose, various models including shape models for anatomical objects are intensively and extensively studied so far. In this short paper, we introduce three related topics from our research results, which are (1) uncertainty quantification of anatomical landmarks, (2) non-rigid ICP (iterative closest point) with statistical shape model and outlier consideration, and (3) variational methods for computation of shape average for a 2D point distribution model and a grey-valued image-based shape representation. In each topic, preliminary results are shown by using clinical data sets to prove the clinical feasibility of the proposed models.
Experimental system for measurement of radiologists' performance by visual search task

Eriko Maeda, Takeharu Yoshikawa, Ryoichi Nakashima, Kazufumi Kobayashi, Kazuhiko Yokosawa, Naoto Hayashi, Yoshitaka Masutani, Naoki Yoshioka, Masaaki Akahane, Kuni Ohtomo

SPRINGERPLUS　2　2013

DOI： 10.1186/2193-1801-2-607 　

ISSN： 2193-1801
New diffusion metrics for spondylotic myelopathy at an early clinical stage Peer-reviewed

Masaaki Hori, Issei Fukunaga, Yoshitaka Masutani, Atsushi Nakanishi, Keigo Shimoji, Koji Kamagata, Koichi Asahi, Nozomi Hamasaki, Yuriko Suzuki, Shigeki Aoki

EUROPEAN RADIOLOGY　22　(8)　1797-1802　2012/08

DOI： 10.1007/s00330-012-2410-9 　

ISSN： 0938-7994
ランドマーク検出器における最適ROI形状の推定 Kullback-Leibler divergenceを用いたROI形状決定アルゴリズム Peer-reviewed

花岡昇平, 増谷佳孝, 根本充貴, 野村行弘, 三木聡一郎, 吉川健啓, 林直人, 大友邦

MEDICAL IMAGING TECHNOLOGY　30　(Suppl.)　1-10　2012/08
Publisher: 日本医用画像工学会
ISSN： 0288-450X
4D digitally reconstructed radiography for verifying a lung tumor position during volumetric modulated arc therapy

Keiichi Nakagawa, Satoshi Kida, Akihiro Haga, Yoshitaka Masutani, Hideomi Yamashita, Tsuyoshi Onoe, Toshikazu Imae, Kenichiro Tanaka, Kuni Ohtomo, Kiyoshi Yoda

JOURNAL OF RADIATION RESEARCH　53　(4)　628-632　2012/07

DOI： 10.1093/jrr/rrs013 　

ISSN： 0449-3060
In-treatment 4D cone-beam CT with image-based respiratory phase recognition. Peer-reviewed

Satoshi Kida, Yoshitaka Masutani, Hideomi Yamashita, Toshikazu Imae, Taeko Matsuura, Naoya Saotome, Kuni Ohtomo, Keiichi Nakagawa, Akihiro Haga

Radiological physics and technology　5　(2)　138-47　2012/07

DOI： 10.1007/s12194-012-0146-5 　

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The use of respiration-correlated cone-beam computed tomography (4D-CBCT) appears to be crucial for implementing precise radiation therapy of lung cancer patients. The reconstruction of 4D-CBCT images requires a respiratory phase. In this paper, we propose a novel method based on an image-based phase recognition technique using normalized cross correlation (NCC). We constructed the respiratory phase by searching for a region in an adjacent projection that achieves the maximum correlation with a region in a reference projection along the cranio-caudal direction. The data on 12 lung cancer patients acquired just prior to treatment and on 3 lung cancer patients acquired during volumetric modulated arc therapy treatment were analyzed in the search for the effective area of cone-beam projection images for performing NCC with 12 combinations of registration area and segment size. The evaluation was done by a "recognition rate" defined as the ratio of the number of peak inhales detected with our method to that detected by eye (manual tracking). The average recognition rate of peak inhale with the most efficient area in the present method was 96.4%. The present method was feasible even when the diaphragm was outside the field of view. With the most efficient area, we reconstructed in-treatment 4D-CBCT by dividing the breathing signal into four phase bins; peak exhale, peak inhale, and two intermediate phases. With in-treatment 4D-CBCT images, it was possible to identify the tumor position and the tumor size in moments of inspiration and expiration, in contrast to in-treatment CBCT reconstructed with all projections.
Integration of corticospinal tractography reduces motor complications after radiosurgery. International-journal

Tomoyuki Koga, Masahiro Shin, Keisuke Maruyama, Kyousuke Kamada, Takahiro Ota, Daisuke Itoh, Naoto Kunii, Kenji Ino, Shigeki Aoki, Yoshitaka Masutani, Hiroshi Igaki, Tsuyoshi Onoe, Nobuhito Saito

International journal of radiation oncology, biology, physics　83　(1)　129-33　2012/05/01

DOI： 10.1016/j.ijrobp.2011.05.036 　

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PURPOSE: To evaluate whether the use of diffusion-tensor tractography (DTT) of the corticospinal tract could reduce motor complications after stereotactic radiosurgery (SRS). METHODS AND MATERIALS: Patients with arteriovenous malformation (AVM) in the deep frontal lobe, deep parietal lobe, basal ganglia, and thalamus who had undergone radiosurgery since 2000 and were followed up for more than 3 years were studied. DTT of the corticospinal tract had been integrated into treatment planning of SRS since 2004, and the maximum dose received by the corticospinal tract was attempted to be less than 20 Gy. Treatment outcomes before (28 patients, Group A) and after (24 patients, Group B) the introduction of this technique were compared. RESULTS: There were no statistical differences between the two groups (Group A vs. Group B) in patients' age (34 years vs. 33 years, p = 0.76), percentage of patients with hemorrhagic events before treatment (50% vs. 29%, p = 0.12), or percentage of AVM involving the basal ganglia and thalamus (36% vs. 46%, p = 0.46). Obliteration rates were 69% and 76% at 4 years in Groups A and B, respectively (p = 0.68), which were not significantly different. Motor complications were observed in 5 patients in Group A (17.9%) but only in 1 patient in Group B (4.2%), which was significantly less frequent (p = 0.021). CONCLUSION: Integrating DTT of the corticospinal tract into treatment planning contributed to reduction of motor complications without compromising the obliteration rate for AVM adjacent to the corticospinal tract.
Tract-specific analysis of white matter integrity disruption in schizophrenia Peer-reviewed

Natsuko Kunimatsu, Shigeki Aoki, Akira Kunimatsu, Osamu Abe, Haruyasu Yamada, Yoshitaka Masutani, Kiyoto Kasai, Hidenori Yamasue, Kuni Ohtomo

Psychiatry Research - Neuroimaging　201　(2)　136-143　2012/02/28

DOI： 10.1016/j.pscychresns.2011.07.010 　

ISSN： 0925-4927

eISSN： 1872-7506
CIRCUS+ 遠隔読影環境のための統合的診断支援およびCAD開発プラットフォーム Peer-reviewed

増谷佳孝, 野村行弘, 三木聡一郎, 臼井敦, 大野孝, 原真, 松尾義朋, 吉川健啓, 林直人, 大友邦

日本医学放射線学会学術集会抄録集　71回　S391-S391　2012/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
臨床における統合的CAD開発環境の構築(第五報) ジョブ分散処理に対応したCADサーバ Peer-reviewed

野村行弘, 林直人, 増谷佳孝, 三木聡一郎, 花岡昇平, 根本充貴, 吉川健啓, 大友邦

日本医学放射線学会学術集会抄録集　71回　S391-S391　2012/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
OUTCOMES OF DIFFUSION TENSOR TRACTOGRAPHY-INTEGRATED STEREOTACTIC RADIOSURGERY Peer-reviewed

Tomoyuki Koga, Keisuke Maruyama, Kyousuke Kamada, Takahiro Ota, Masahiro Shin, Daisuke Itoh, Naoto Kunii, Kenji Ino, Atsuro Terahara, Shigeki Aoki, Yoshitaka Masutani, Nobuhito Saito

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS　82　(2)　799-802　2012/02

DOI： 10.1016/j.ijrobp.2010.11.046 　

ISSN： 0360-3016
Alignment and Morphing for the Boundary Curves of Anatomical Organs Peer-reviewed

Keiko Morita, Atsushi Imiya, Tomoya Sakai, Hidetaka Hontan, Yoshitaka Masutani

STRUCTURAL, SYNTACTIC, AND STATISTICAL PATTERN RECOGNITION　7626　458-466　2012

DOI： 10.1007/978-3-642-34166-3_50 　

ISSN： 0302-9743
SU‐E‐J‐203: Determination of PTV Margin for Lung Tumor Using In‐Treatment 4D CBCT

A. Haga, K. Nakagawa, H. Yamashita, W. Takahashi, A. Sakumi, Y. Masutani, S. Kida, N. Saotome, S. Itoh, T. Shiraki, K. Ohtomo

Medical Physics　39　(6)　3699　2012

DOI： 10.1118/1.4735043 　

ISSN： 0094-2405
SU‐E‐J‐33: Geometric Agreement Check for Imaging System with Radiation Beam by KV and MV‐CBCT

N. Saotome, S. Kida, A. Haga, Y. Masutani, K. Ohtomo, K. Nakagawa

Medical Physics　39　(6)　3659　2012

DOI： 10.1118/1.4734866 　

ISSN： 0094-2405
Automatic Categorization of Anatomical Landmark-Local Appearances Based on Diffeomorphic Demons and Spectral Clustering for Constructing Detector Ensembles

Shouhei Hanaoka, Yoshitaka Masutani, Mitsutaka Nemoto, Yukihiro Nomura, Takeharu Yoshikawa, Naoto Hayashi, Kuni Ohtomo

MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2012, PT II　7511　106-113　2012

ISSN： 0302-9743

eISSN： 1611-3349
Appearance Similarity Flow for Quantification of Anatomical Landmark Uncertainty in Medical Images

Yoshitaka Masutani, Mitsutaka Nemoto, Shohei Hanaoka, Naoto Hayashi, Kuni Ohtomo

ADVANCES IN VISUAL COMPUTING, ISVC 2012, PT I　7431　12-21　2012

ISSN： 0302-9743

eISSN： 1611-3349
A new diffusion metric, diffusion kurtosis imaging, used in the serial examination of a patient with stroke. Peer-reviewed

Hori M, Aoki S, Fukunaga I, Suzuki Y, Masutani Y

Acta radiologica short reports　1　(1)　2012

DOI： 10.1258/arsr.2011.110024 　
[Clinical application of diffusion MR imaging of the brain]. Peer-reviewed

Aoki S, Hori M, Masutani Y, Abe O, Kamagata K, Hattori T

Rinsho shinkeigaku = Clinical neurology　51　(11)　955-955　2011/11
Publisher: 11
DOI： 10.5692/clinicalneurol.51.955 　

ISSN： 0009-918X
4D-CBCT reconstruction using MV portal imaging during volumetric modulated arc therapy

Satoshi Kida, Naoya Saotome, Yoshitaka Masutani, Hideomi Yamashita, Kuni Ohtomo, Keiichi Nakagawa, Akira Sakumi, Akihiro Haga

RADIOTHERAPY AND ONCOLOGY　100　(3)　380-385　2011/09

DOI： 10.1016/j.radonc.2011.08.047 　

ISSN： 0167-8140

eISSN： 1879-0887
Integrated Lymphography Using Fluorescence Imaging and Magnetic Resonance Imaging in Intact Mice International-journal Peer-reviewed

Yusuke Inoue, Yoshitaka Masutani, Shigeru Kiryu, Tomoyuki Haishi, Kohki Yoshikawa, Makoto Watanabe, Morio Shimada, Kuni Ohtomo

MOLECULAR IMAGING　10　(5)　317-326　2011/09

DOI： 10.2310/7290.2010.00049 　

ISSN： 1535-3508
Distortion correction in whole-body imaging of live mice using a 1-Tesla compact magnetic resonance imaging system Peer-reviewed

Shigeru Kiryu, Yusuke Inoue, Yoshitaka Masutani, Tomoyuki Haishi, Kohki Yoshikawa, Makoto Watanabe, Kuni Ohtomo

JAPANESE JOURNAL OF RADIOLOGY　29　(5)　353-360　2011/06

DOI： 10.1007/s11604-010-0553-7 　

ISSN： 1867-1071

eISSN： 1867-108X
臨床使用に即した新しいCAD検出性能指標に基づく病変候補提示法の調整に関する研究 Peer-reviewed

三木聡一郎, 野村行弘, 林直人, 増谷佳孝, 吉川健啓, 根本充貴, 花岡昇平, 大友邦

日本医学放射線学会学術集会抄録集　70回　S221-S221　2011/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
CTによる臍レベル内臓脂肪面積と腹囲の測定における測定の位置ずれに対する計測値の頑強性 Peer-reviewed

エルヌル・トスフハン, 根本充貴, 林直人, 野村行弘, 増谷佳孝, 吉川健啓, 三木聡一郎, 花岡昇平, 伊藤賢司, 大友邦

日本医学放射線学会学術集会抄録集　70回　S347-S347　2011/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
臨床における統合的CAD開発環境の構築(第四報) 読影医とCADの協調的パフォーマンス向上 Peer-reviewed

野村行弘, 林直人, 増谷佳孝, 吉川健啓, 根本充貴, 花岡昇平, 三木聡一郎, 大友邦

日本医学放射線学会学術集会抄録集　70回　S379-S379　2011/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
Cone Beam Computed Tomography Data Acquisition during VMAT Delivery with Subsequent Respiratory Phase Sorting Based on Projection Image Cross-correlation

NAKAGAWA Keiichi, KIDA Satoshi, HAGA Akihiro, MASUTANI Yoshitaka, YAMASHITA Hideomi, IMAE Toshikazu, TANAKA Kenichiro, OHTOMO Kuni, IWAI Yoshio, YODA Kiyoshi

Journal of Radiation Research　52　(1)　112-113　2011/01/16
Publisher: Journal of Radiation Research Editorial Committee
DOI： 10.1269/jrr.10170 　

ISSN： 0449-3060
SU‐E‐T‐530: Projection Image Correction for 4D VMAT‐CT

N. Saotome, S. Kida, T. Onoe, K. Sasaki, T. Imae, K. Tanaka, A. Sakumi, Y. Masutani, A. Haga, K. Nakagawa

Medical Physics　38　(6)　3611　2011

DOI： 10.1118/1.3612492 　

ISSN： 0094-2405
CTデータにおける内臓脂肪体積と臍レベル内臓脂肪面積の自動計測の精度 Peer-reviewed

エルヌル・ストフハン, 根本充貴, 野村行弘, 増谷佳孝, 花岡昇平, 伊藤賢司, 大友邦, 林直人, 吉川健啓, 宇野漢成

Japanese Journal of Radiology　29　(Suppl.I)　25-25　2011/01
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
3-D Graph Cut Segmentation with Riemannian Metrics to Avoid the Shrinking Problem

Shouhei Hanaoka, Karl Fritscher, Martin Welk, Mitsutaka Nemoto, Yoshitaka Masutani, Naoto Hayashi, Kuni Ohtomo, Rainer Schubert

MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION, MICCAI 2011, PT III　6893　554-+　2011

ISSN： 0302-9743

eISSN： 1611-3349
Whole vertebral bone segmentation method with a statistical intensity-shape model based approach Peer-reviewed

Shouhei Hanaoka, Karl Fritscher, Benedikt Schuler, Yoshitaka Masutani, Naoto Hayashi, Kuni Ohtomo, Rainer Schubert

MEDICAL IMAGING 2011: IMAGE PROCESSING　7962　2011

DOI： 10.1117/12.878151 　

ISSN： 0277-786X
Mathematical Foundations and Applications of Landmarks and Semi-Landmarks in Computational Anatomy

MASUTANI Yoshitaka, HONTANI Hidekata, IMIYA Atsushi

Medical Imaging Technology　29　(3)　104-110　2011
Publisher: The Japanese Society of Medical Imaging Technology
DOI： 10.11409/mit.29.104 　

ISSN： 2185-3193

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One of the purposes of the emerging discipline, Computational Anatomy, is construction of Computational Anatomy Model, which is a set of computational and statistical expressions of anatomical knowledge including organ shapes and structures and plays a key role in medical image understanding. In addition, the model is finally mapped to new patient data for supporting diagnosis and therapy in clinical processes. That is, the mathematical problems on computational anatomy oriented to clinical applications lead to the subjects; how to express anatomical knowledge for medical image understanding and how to map them to new data. In this paper, we briefly review literature and discuss the subjects and also present our research results focusing on landmarks as a minimum unit for anatomical knowledge, model-image registration by using semi-landmarks and variational shape average of planar polygons for organ shapes.
A unified framework for concurrent detection of anatomical landmarks for medical image understanding. Peer-reviewed

Mitsutaka Nemoto, Yoshitaka Masutani, Shouhei Hanaoka, Yukihiro Nomura, Takeharu Yoshikawa, Naoto Hayashi, Naoki Yoshioka, Kuni Ohtomo

Medical Imaging 2011: Image Processing　79623　2011
Publisher: SPIE
DOI： 10.1117/12.878327 　
Age-related changes in regional brain volume evaluated by atlas-based method International-journal Peer-reviewed

Gonoi Wataru, Abe Osamu, Yamasue Hidenori, Yamada Haruyasu, Masutani Yoshitaka, Takao Hidemasa, Kasai Kiyoto, Aoki Shigeki, Ohtomo Kuni

NEURORADIOLOGY　52　(10)　865-873　2010/10

DOI： 10.1007/s00234-009-0641-5 　

ISSN： 0028-3940
Diffusion tensor tract-specific analysis of the uncinate fasciculus in patients with amyotrophic lateral sclerosis Peer-reviewed

Kanako Sato, Shigeki Aoki, Nobue K. Iwata, Yoshitaka Masutani, Takeyuki Watadani, Yasuhiro Nakata, Mariko Yoshida, Yasuo Terao, Osamu Abe, Kuni Ohtomo, Shoji Tsuji

NEURORADIOLOGY　52　(8)　729-733　2010/08

DOI： 10.1007/s00234-010-0653-1 　

ISSN： 0028-3940
体幹部CT像上の解剖学的ランドマーク自動検出法に関する初期検討 Peer-reviewed

根本充貴, 野村行弘, 花岡昇平, 増谷佳孝, 吉川健啓, 林直人, 吉岡直紀, 大友邦

MEDICAL IMAGING TECHNOLOGY　28　(Suppl.)　1-10　2010/07
Publisher: 日本医用画像工学会
ISSN： 0288-450X
肺野領域の過小抽出を考慮した胸壁付着結節検出に関する初期的検討 Peer-reviewed

野村行弘, 根本充貴, 増谷佳孝, 花岡昇平, 吉川健啓, 林直人, 吉岡直紀, 大友邦

MEDICAL IMAGING TECHNOLOGY　28　(Suppl.)　1-7　2010/07
Publisher: 日本医用画像工学会
ISSN： 0288-450X
CADソフトウェアの臨床応用/評価/追加学習を目的としたWebベースのCAD実行環境処理結果およびフィードバックに基づく解析機能の実装 Peer-reviewed

野村行弘, 林直人, 増谷佳孝, 吉川健啓, 根本充貴, 花岡昇平, 三木聡一郎, 前田恵理子, 大友邦

MEDICAL IMAGING TECHNOLOGY　28　(Suppl.)　1-7　2010/07
Publisher: 日本医用画像工学会
ISSN： 0288-450X
Sex dimorphism in gray/white matter volume and diffusion tensor during normal aging International-journal Peer-reviewed

Abe Osamu, Yamasue Hidenori, Yamada Haruyasu, Masutani Yoshitaka, Kabasawa Hiroyuki, Sasaki Hiroki, Takei Kunio, Suga Motomu, Kasai Kiyoto, Aoki Shigeki, Ohtomo Kuni

NMR IN BIOMEDICINE　23　(5)　446-458　2010/06

DOI： 10.1002/nbm.1479 　

ISSN： 0952-3480
Integrated Imaging Approach to Tumor Model Mice Using Bioluminescence Imaging and Magnetic Resonance Imaging International-journal Peer-reviewed

Yusuke Inoue, Yoshitaka Masutani, Shigeru Kiryu, Tomoyuki Haishi, Makoto Watanabe, Arinobu Tojo, Kuni Ohtomo

MOLECULAR IMAGING　9　(3)　163-172　2010/05

DOI： 10.2310/7290.2010.00013 　

ISSN： 1535-3508

eISSN： 1536-0121
臨床における統合的CAD開発環境の構築(第三報) Peer-reviewed

野村行弘, 林直人, 増谷佳孝, 吉川健啓, 根本充貴, 花岡昇平, 前田恵理子, 大友邦

日本医学放射線学会学術集会抄録集　69回　S377-S377　2010/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
自動計測によるCT内臓脂肪体積を基準とした内臓脂肪指標の評価 Peer-reviewed

エルヌル・トスフハン, 根本充貴, 野村行弘, 増谷佳孝, 花岡昇平, 伊藤賢司, 林直人, 宇野漢成, 吉川健啓, 大友邦

日本医学放射線学会学術集会抄録集　69回　S204-S204　2010/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
Voxel-based analyses of gray/white matter volume and diffusion tensor data in major depression Peer-reviewed

Osamu Abe, Hidenori Yamasue, Kiyoto Kasai, Haruyasu Yamada, Shigeki Aoki, Hideyuki Inoue, Kunio Takei, Motomu Suga, Koji Matsuo, Tadafumi Kato, Yoshitaka Masutani, Kuni Ohtomo

Psychiatry Research - Neuroimaging　181　(1)　64-70　2010/01/30

DOI： 10.1016/j.pscychresns.2009.07.007 　

ISSN： 0925-4927
Voxel-based analyses of gray/white matter volume and diffusion tensor data in major depression. Peer-reviewed

Abe O, Yamasue H, Kasai K, Yamada H, Aoki S, Inoue H, Takei K, Suga M, Matsuo K, Kato T, Masutani Y, Ohtomo K

Psychiatry research　181　64-70　2010/01/03
Publisher: 1
DOI： 10.1016/j.pscychresns.2009.07.007 　

ISSN： 0165-1781
SU‐GG‐I‐25: CBCT Reconstruction during VMAT Delivery Using Elekta Synergy System Peer-reviewed

S. Kida, T. Matsuura, A. Haga, Y. Masutani, S. Itoh, N. Saotome, A. Sakumi, J. Kotoku, K. Tanaka, K. Nakagawa

Medical Physics　37　(6)　3107　2010

DOI： 10.1118/1.3468058 　

ISSN： 0094-2405
Preliminary Study on Appearance-Based Detection of Anatomical Point Landmarks in Body Trunk CT Images

Mitsutaka Nemoto, Yukihiro Nomura, Shohei Hanaoka, Yoshitaka Masutani, Takeharu Yoshikawa, Naoto Hayashi, Naoki Yoshioka, Kuni Ohtomo

MACHINE LEARNING IN MEDICAL IMAGING　6357　174-181　2010

ISSN： 0302-9743

eISSN： 1611-3349
CIRCUS: an MDA Platform for Clinical Image Analysis in Hospitals. Peer-reviewed

Yukihiro Nomura, Naoto Hayashi, Yoshitaka Masutani, Takeharu Yoshikawa, Mitsutaka Nemoto, Shohei Hanaoka, Soichiro Miki, Eriko Maeda, Kuni Ohtomo

Trans. Mass-Data Analysis of Images and Signals　2　(1)　112-127　2010
Automated segmentation method for spinal column based on a dual elliptic column model and its application for virtual spinal straightening. International-journal Peer-reviewed

Shouhei Hanaoka, Yukihiro Nomura, Mitsutaka Nemoto, Yoshitaka Masutani, Eriko Maeda, Takeharu Yoshikawa, Naoto Hayashi, Naoki Yoshioka, Kuni Ohtomo

Journal of computer assisted tomography　34　(1)　156-62　2010/01

DOI： 10.1097/RCT.0b013e3181b12242 　

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Segmentation of vertebral bones in computed tomographic data is important as a first stage of image-based radiological tasks. However, it is a challenging problem to segment an affected spine correctly. In this study, we propose a new method of segmentation of thoracic and lumbar vertebral bodies from thin-slice computed tomographic images. Especially, we focus on a deformable model-based segmentation scheme to confirm the feasibility in clinical data sets with various bone diseases, such as bone metastases and scoliosis. As an application of this algorithm, virtual straightening of the thoracolumbar spine is also performed. Results on a database of 16 patients indicate the applicability of our method to spines affected by scoliosis and multiple bone metastases.
Motion-robust diffusion tensor acquisition at routine 3T magnetic resonance imaging Peer-reviewed

Hasina Yasmin, Hiroyuki Kabasawa, Shigeki Aoki, Osamu Abe, Yoshitaka Masutani, Naoto Hayashi, Kuni Ohtomo

JAPANESE JOURNAL OF RADIOLOGY　28　(1)　27-33　2010/01

DOI： 10.1007/s11604-009-0378-4 　

ISSN： 1867-108X
Cylindrical SUV Distribution Model for Detecting Skin Lesions in Body Trunk FDG-PET/CT Images Peer-reviewed

NEMOTO Mitsutaka, NOMURA Yukihiro, MASUTANI Yoshitaka, HANAOKA Shouhei, YOSHIKAWA Takeharu, HAYASHI Naoto, YOSHIOKA Naoki, OHTOMO Kuni

Medical Imaging Technology　28　(1)　42-52　2010/01
Publisher: 日本医用画像工学会
ISSN： 0288-450X
Motion-robust diffusion tensor acquisition at routine 3T magnetic resonance imaging. Peer-reviewed

Hasina Yasmin, Hiroyuki Kabasawa, Shigeki Aoki, Osamu Abe, Yoshitaka Masutani, Naoto Hayashi, Kuni Ohtomo

Japanese journal of radiology　28　(1)　27-33　2010/01

DOI： 10.1007/s11604-009-0378-4 　

ISSN： 1867-1071

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PURPOSE: We compared different acquisition and reconstruction methods in phantom and human studies in the clinical setting to validate our hypothesis that optimizing the k-space acquisition and reconstruction method could decrease motion artifacts. MATERIALS AND METHODS: Diffusion tensor images of a water phantom were obtained with three table displacement magnitudes: 1 mm, 2 mm, and 3 mm. Images were reconstructed using homodyne and zero-fill reconstruction. Overscanning in 8- and 16-k(y) lines was tested. We performed visual assessment of the artifacts using reconstructed coronal images and analyzed them with Wilcoxon signed-ranks test both for phantom and human studies. Also, fractional anisotropy (FA) changes between acquisition methods were compared. RESULTS: Artifacts due to smaller displacement (1 and 2 mm) were significantly reduced in 16-k(y) overscan with zero filling. The Wilcoxon signed-ranks test showed significant differences (P < 0.031 for reconstruction methods and P < 0.016 for overscanning methods). FA changes were statistically significant (P < 0.037; Student's t-test). The Wilcoxon signed-ranks test showed significant reductions (P < 0.005) in the human study. CONCLUSION: Motion-induced artifacts can be reduced by optimizing acquisition and reconstruction methods. The techniques described in this study offer an effective method for robust estimation of diffusion tensor in the presence of motion-related artifactual data points.
Tract-specific analysis of white matter pathways in healthy subjects: a pilot study using diffusion tensor MRI. Peer-reviewed

Yasmin H, Aoki S, Abe O, Nakata Y, Hayashi N, Masutani Y, Goto M, Ohtomo K

Neuroradiology　51　(12)　831-840　2009/12

DOI： 10.1007/s00234-009-0580-1 　

ISSN： 0028-3940
The motor-evoked potential threshold evaluated by tractography and electrical stimulation. International-journal

Kyousuke Kamada, Tomoki Todo, Takahiro Ota, Kenji Ino, Yoshitaka Masutani, Shigeki Aoki, Fumiya Takeuchi, Kensuke Kawai, Nobuhito Saito

Journal of neurosurgery　111　(4)　785-95　2009/10

DOI： 10.3171/2008.9.JNS08414 　

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OBJECT: To validate the corticospinal tract (CST) illustrated by diffusion tensor imaging, the authors used tractography-integrated neuronavigation and direct fiber stimulation with monopolar electric currents. METHODS: Forty patients with brain lesions adjacent to the CST were studied. During the operation, the motor responses (motor evoked potential [MEP]) elicited at the hand by the cortical stimulation to the hand motor area were continuously monitored, maintaining the consistent stimulus intensity (mean 15.1 +/- 2.21 mA). During lesion resection, direct fiber stimulation was applied to elicit MEP (referred to as fiber MEP) to identify the CST functionally. The threshold intensity for the fiber MEP was determined by searching for the best stimulus point and changing the stimulus intensity. The minimum distance between the resection border and illustrated CST was measured on postoperative isotropic images. RESULTS: Direct fiber stimulation demonstrated that tractography accurately reflected anatomical CST functioning. There were strong correlations between stimulus intensity for the fiber MEP and the distance between the CST and the stimulus points. The results indicate that the minimum stimulus intensity of 20, 15, 10, and 5 mA had stimulus points approximately 16, 13.2, 9.6, and 4.8 mm from the CST, respectively. The convergent calculation formulated 1.8 mA as the electrical threshold of the CST for the fiber MEP, which was much smaller than that of the hand motor area. CONCLUSIONS: The investigators found that diffusion tensor imaging-based tractography is a reliable way to map the white matter connections in the entire brain in clinical and basic neuroscience applications. By combining these techniques, investigating the cortical-subcortical connections in the human CNS could contribute to elucidating the neural networks of the human brain and shed light on higher brain functions.
Arcuate fasciculus tractography integrated into Gamma Knife surgery Clinical article Peer-reviewed

Keisuke Maruyama, Tomoyuki Koga, Kyousuke Kamada, Takahiro Ota, Daisuke Itoh, Kenji Ino, Hiroshi Igaki, Shigeki Aoki, Yoshitaka Masutani, Masahiro Shin, Nobuhito Saito

JOURNAL OF NEUROSURGERY　111　(3)　520-526　2009/09

DOI： 10.3171/2008.4.17521 　

ISSN： 0022-3085

eISSN： 1933-0693
臨床における統合的CAD開発環境の構築フィードバック入力機能の実装 Peer-reviewed

野村行弘, 林直人, 増谷佳孝, 吉川健啓, 根本充貴, 花岡昇平, 前田恵理子, 大友邦

MEDICAL IMAGING TECHNOLOGY　27　(Suppl.)　1-8　2009/08
Publisher: 日本医用画像工学会
ISSN： 0288-450X
体幹部FDG-PET/CT像からの皮膚病変検出処理に関する検討円筒状標準SUVモデルを用いた皮膚病変の検出 Peer-reviewed

根本充貴, 野村行弘, 増谷佳孝, 花岡昇平, 吉川健啓, 林直人, 吉岡直紀, 大友邦

MEDICAL IMAGING TECHNOLOGY　27　(Suppl.)　1-10　2009/08
Publisher: 日本医用画像工学会
ISSN： 0288-450X
体幹部CT画像における椎体骨転移のコンピュータ支援画像診断の初期的検討 Peer-reviewed

花岡昇平, 野村行弘, 根本充貴, 増谷佳孝, 前田恵理子, 吉川健啓, 林直人, 吉岡直紀, 大友邦

MEDICAL IMAGING TECHNOLOGY　27　(Suppl.)　1-8　2009/08
Publisher: 日本医用画像工学会
ISSN： 0288-450X
局所構造解析による血管分岐の特徴抽出の初期的検討 Peer-reviewed

野村行弘, 増谷佳孝, 根本充貴, 花岡昇平, 吉川健啓, 林直人, 吉岡直紀, 大友邦

MEDICAL IMAGING TECHNOLOGY　27　(Suppl.)　1-7　2009/08
Publisher: 日本医用画像工学会
ISSN： 0288-450X
体幹部CT像上の内臓脂肪量自動計測手法の提案 Peer-reviewed

根本充貴, 野村行弘, 増谷佳孝, エルヌル・トスフハン, 花岡昇平, 吉川健啓, 林直人, 吉岡直紀, 大友邦

MEDICAL IMAGING TECHNOLOGY　27　(Suppl.)　1-8　2009/08
Publisher: 日本医用画像工学会
ISSN： 0288-450X
Formation of long-term memory representation in human temporal cortex related to pictorial paired associates. Peer-reviewed

Yamashita K, Hirose S, Kunimatsu A, Aoki S, Chikazoe J, Jimura K, Masutani Y, Abe O, Ohtomo K, Miyashita Y, Konishi S

The Journal of neuroscience : the official journal of the Society for Neuroscience　29　(33)　10335-10340　2009/08

DOI： 10.1523/JNEUROSCI.1328-09.2009 　

ISSN： 0270-6474
Diffusion abnormality in the posterior cingulum and hippocampal volume: correlation with disease progression in Alzheimer's disease Peer-reviewed

Yasuhiro Nakata, Noriko Sato, Kiyotaka Nemoto, Osamu Abe, Shoko Shikakura, Kunimasa Arima, Nobuo Furuta, Masatake Uno, Shigeo Hirai, Yoshitaka Masutani, Kuni Ohtomo, A. James Barkovich, Shigeki Aoki

MAGNETIC RESONANCE IMAGING　27　(3)　347-354　2009/04

DOI： 10.1016/j.mri.2008.07.013 　

ISSN： 0730-725X
Improvement in Performance of Computerized Detection Method for Lung Nodules With Use of Additional Classifier for Juxtapleural Nodules Peer-reviewed

NOMURA Yukihiro, NEMOTO Mitsutaka, MASUTANI Yoshitaka, ITO Haruhiko, MAEDA Eriko, HANAOKA Shouhei, YOSHIKAWA Takeharu, HAYASHI Naoto, YOSHIOKA Naoki, OHTOMO Kuni

Medical Imaging Technology　27　(2)　123-131　2009/03
Publisher: 日本医用画像工学会
ISSN： 0288-450X
臨床における統合的CAD開発環境の構築(第二報) Peer-reviewed

野村行弘, 増谷佳孝, 大友邦, 林直人, 吉川健啓, 前田恵理子, 津田寿実, 原真, 椛沢宏之, 野崎敦

日本医学放射線学会学術集会抄録集　68回　S407-S407　2009/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
側彎症、多発骨転移に対応した全脊椎の自動セグメンテーションおよびCPR作成 Peer-reviewed

花岡昇平, 野村行弘, 根本充貴, 増谷佳孝, 前田恵理子, 吉川健啓, 林直人, 吉岡直紀, 大友邦

日本医学放射線学会学術集会抄録集　68回　S326-S327　2009/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
Tract-specific analysis of the superior occipitofrontal fasciculus in schizophrenia Peer-reviewed

Natsuko Kunimatsu, Shigeki Aoki, Akira Kunimatsu, Mariko Yoshida, Osamu Abe, Haruyasu Yamada, Yoshitaka Masutani, Kiyoto Kasai, Hidenori Yamasue, Hiroshi Ohtsu, Kuni Ohtomo

Psychiatry Research - Neuroimaging　164　(3)　198-205　2008/12/30

DOI： 10.1016/j.pscychresns.2008.03.004 　

ISSN： 0925-4927
Tract-specific analysis of the superior occipitofrontal fasciculus in schizophrenia. International-journal Peer-reviewed

Natsuko Kunimatsu, Shigeki Aoki, Akira Kunimatsu, Mariko Yoshida, Osamu Abe, Haruyasu Yamada, Yoshitaka Masutani, Kiyoto Kasai, Hidenori Yamasue, Hiroshi Ohtsu, Kuni Ohtomo

Psychiatry research　164　(3)　198-205　2008/12/30
Publisher: 3
DOI： 10.1016/j.pscychresns.2008.03.004 　

ISSN： 0165-1781

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Diffusion tensor imaging has been highlighted as a non-invasive tool to explore neural connectivity in vivo. Several studies have suggested disorganization of the neural network (circuitry) including the thalamo-prefrontal connection in schizophrenia. Recent research using post-mortem brains showed that the superior occipitofrontal fasciculus (SOFF) fibers extended to the thalamus. We postulated that the SOFF has some relationship with the anatomical structural components of the thalamo-prefrontal circuitry. We quantitatively assessed the diffusion abnormalities of the SOFF using diffusion tensor tractography (DTT) in schizophrenia. Nineteen male patients with schizophrenia and 20 age-matched normal controls were studied. DTT of the SOFF (DTT-SOFF) was visualized using free software (dTV II/VOLUME-ONE), and we performed tract-specific measurement of the fractional anisotropy (FA), then calculated the apparent diffusion coefficient (ADC) of the DTT-SOFF. Tractography and tract-specific analysis of the SOFF were successfully performed in all subjects. All tracts appeared to be connecting the prefrontal area to the thalamus. The mean FA value of patients with schizophrenia [0.376 (S.D. 0.030)] was significantly lower than that of controls [0.432 (S.D. 0.032)], and the ADC value of patients with schizophrenia [0.771 (x10(-3) mm(2)/s) (S.D. 0.041)] was significantly higher than that of controls [0.726 (x10(-3) mm(2)/s) (S.D. 0.027)]. Our results suggest that the so-called SOFF may be a structural component connecting the prefrontal area to the thalamus and that it is deteriorated in schizophrenia.
Diffusion-tensor neuronal fiber tractography and manganese-enhanced MR imaging of primate visual pathway in the common marmoset: preliminary results. Peer-reviewed

Yamada M, Momoshima S, Masutani Y, Fujiyoshi K, Abe O, Nakamura M, Aoki S, Tamaoki N, Okano H

Radiology　249　(3)　855-864　2008/12

DOI： 10.1148/radiol.2493072141 　

ISSN： 0033-8419
Diffusion abnormality in posterior cingulate fiber tracts in Alzheimer's disease: tract-specific analysis. Peer-reviewed

Nakata Y, Sato N, Abe O, Shikakura S, Arima K, Furuta N, Uno M, Hirai S, Masutani Y, Ohtomo K, Aoki S

Radiation medicine　26　(8)　466-473　2008/10
Publisher: 8
DOI： 10.1007/s11604-008-0258-3 　

ISSN： 0288-2043
Diffusion abnormality in posterior cingulate fiber tracts in Alzheimer's disease: tract-specific analysis Peer-reviewed

Nakata Yasuhiro, Sato Noriko, Abe Osamu, Shikakura Shoko, Arima Kunimasa, Furuta Nobuo, Uno Masatake, Hirai Shigeo, Masutani Yoshitaka, Ohtomo Kuni, Aoki Shigeki

RADIATION MEDICINE　26　(8)　466-473　2008/10

DOI： 10.1007/s11604-008-0258-3 　

ISSN： 1862-5274
Diffusion tensor imaging of the brain: effects of distortion correction with correspondence to numbers of encoding directions Peer-reviewed

Yoshikawa Takeharu, Aoki Shigeki, Abe Osamu, Hayashi Naoto, Masutani Yoshitaka, Masumoto Tomohiko, Mori Harushi, Satake Yoshiroh, Ohtomo Kuni

RADIATION MEDICINE　26　(8)　481-487　2008/10

DOI： 10.1007/s11604-008-0262-7 　

ISSN： 1862-5274
体幹部PET/CT画像における皮膚病変領域自動検出法の開発に関する基礎的検討 Peer-reviewed

根本充貴, 野村行弘, 増谷佳孝, 花岡昇平, 吉川健啓, 林直人, 吉岡直紀, 大友邦

MEDICAL IMAGING TECHNOLOGY　26　(Suppl.)　B4-03　2008/08
Publisher: 日本医用画像工学会
ISSN： 0288-450X
側彎に対応した全脊椎の自動CTセグメンテーション Peer-reviewed

花岡昇平, 野村行弘, 根本充貴, 増谷佳孝, 前田恵理子, 吉川健啓, 林直人, 吉岡直紀, 大友邦

MEDICAL IMAGING TECHNOLOGY　26　(Suppl.)　B5-06　2008/08
Publisher: 日本医用画像工学会
ISSN： 0288-450X
胸壁付着結節に対応した識別器の追加による肺結節自動検出システムの改良 Peer-reviewed

野村行弘, 根本充貴, 増谷佳孝, 伊藤治彦, 前田恵理子, 花岡昇平, 吉川健啓, 林直人, 吉岡直紀, 大友邦

MEDICAL IMAGING TECHNOLOGY　26　(Suppl.)　C1-04　2008/08
Publisher: 日本医用画像工学会
ISSN： 0288-450X
A Variational Method for Geometric Regularization of Vascular Segmentation in Medical Images. Peer-reviewed

Ali Gooya, Hongen Liao, Kiyoshi Matsumiya, Ken Masamune, Yoshitaka Masutani, Takeyoshi Dohi

IEEE Trans. Image Processing　17　(8)　1295-1312　2008/08

DOI： 10.1109/TIP.2008.925378 　

ISSN： 1057-7149
Tolerance of pyramidal tract to gamma knife radiosurgery based on diffusion-tensor tractography Peer-reviewed

Keisuke Maruyama, Kyousuke Kamada, Takahmo Ota, Tomoyuk Koga, Daisuke Itoh, Kenji Ino, Shigeki Aoki, Masao Tago, Yoshitaka Masutani, Masahiro Shin, Nobuhito Saito

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS　70　(5)　1330-1335　2008/04

DOI： 10.1016/j.ijrobp.2007.08.010 　

ISSN： 0360-3016
Diffusion abnormalities of the uncinate fasciculus in Alzheimer's disease: diffusion tensor tract-specific analysis using a new method to measure the core of the tract Peer-reviewed

Hasina Yasmin, Yasuhiro Nakata, Shigeki Aoki, Osamu Abe, Noriko Sato, Kiyotaka Nemoto, Kunimasa Arima, Nobuo Furuta, Masatake Uno, Shigeo Hirai, Yoshitaka Masutani, Kuni Ohtomo

NEURORADIOLOGY　50　(4)　293-299　2008/04

DOI： 10.1007/s00234-007-0353-7 　

ISSN： 0028-3940
フリーハンド3次元超音波画像の複数回走査における信頼度を利用した画像合成 Peer-reviewed

野村行弘, 吉川健啓, 林直人, 増谷佳孝, 前田恵理子, 大友邦

日本医学放射線学会学術集会抄録集　67回　S350-S350　2008/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
院内CAD研究開発のための統合環境に関する研究システム設計から試験運用までの初期経験 Peer-reviewed

林直人, 増谷佳孝, 吉川健啓, 前田恵理子, 野村行弘, 野崎敦, 椛沢宏之, 原真, 津田寿実

日本医学放射線学会学術集会抄録集　67回　S370-S370　2008/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
Precise Diffusion Anisotropy Measurement Using Diffusion Tensor MRI

KABASAWA Hiroyuki, MASUTANI Yoshitaka, ABE Osamu, AOKI Shigeki, OHTOMO Kuni

Medical Imaging Technology　26　(3)　162-162　2008
Publisher: The Japanese Society of Medical Imaging Technology
DOI： 10.11409/mit.26.162 　

ISSN： 0288-450X
Quantitative diffusion tensor analysis using multiple tensor ellipsoids model and tensor field interpolation at fiber crossing. International-journal Peer-reviewed

Hiroyuki Kabasawa, Yoshitaka Masutani, Osamu Abe, Shigeki Aoki, Kuni Ohtomo

Academic radiology　15　(1)　84-92　2008/01

DOI： 10.1016/j.acra.2007.07.004 　

ISSN： 1076-6332

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RATIONALE AND OBJECTIVES: In regions of intravoxel fiber crossing, the single-tensor model does not provide accurate results. The previously published models could resolve this issue but needed a long scan time and long computational time. This article aims to present the new model, which uses interpolated diffusion tensor orientations and requires the estimation of fewer parameters than the previously published model, where all parameters for the two diffusion ellipsoids have to be estimated. MATERIALS AND METHODS: Fiber orientation information was reconstructed by using the radial basis function-based interpolation technique from tensor information in given seed regions of interest. Synthetic phantom data were generated, and the proposed method was compared with the conventional two-ellipsoid method. Data from one normal volunteer were analyzed to determine the effectiveness of the proposed method. The number of parameters to be estimated could be reduced by using the estimated fiber orientation information so that diffusion parameter calculation at fiber crossing becomes robust. RESULTS: The human study showed that fractional anisotropy (FA) values estimated by the proposed method (FA = 0.67 for the corpus callosum, 0.65 for the corticospinal tract) were significantly higher than that estimated by the standard single-tensor-based method (FA = 0.35), and the estimated FA value showed good agreement with the FA value in the adjacent fiber bundle. CONCLUSION: The proposed radial basis function-based technique could reconstruct diffusion properties at the fiber-crossing volume from sparse sampling of high angular diffusion weighted images.
Aging in the CNS: Comparison of gray/white matter volume and diffusion tensor data International-journal Peer-reviewed

Abe Osamu, Yamasue Hidenori, Aoki Shigeki, Suga Motomu, Yamada Haruyasu, Kasai Kiyoto, Masutani Yoshitaka, Kato Nobuyuki, Kato Nobumasa, Ohtomo Kuni

NEUROBIOLOGY OF AGING　29　(1)　102-116　2008/01

DOI： 10.1016/j.neurobiolaging.2006.09.003 　

ISSN： 0197-4580

eISSN： 1558-1497
Utilization of diffusion tensor tractography in combination with spatial normalization to assess involvement of the corticospinal tract in capsular/pericapsular stroke: Feasibility and clinical implications Peer-reviewed

Akira Kunimatsu, Daisuke Itoh, Yasuhiro Nakata, Natsuko Kunimatsu, Shigeki Aoki, Yoshitaka Masutani, Osamu Abe, Mariko Yoshida, Manabu Minami, Kuni Ohtomo

JOURNAL OF MAGNETIC RESONANCE IMAGING　26　(6)　1399-1404　2007/12

DOI： 10.1002/jmri.20945 　

ISSN： 1053-1807
3T PROPELLER diffusion tensor fiber tractography: a feasibility study for cranial nerve fiber tracking. Peer-reviewed

Hiroyuki Kabasawa, Yoshitaka Masutani, Shigeki Aoki, Osamu Abe, Tomohiko Masumoto, Naoto Hayashi, Kuni Ohtomo

Radiation medicine　25　(9)　462-6　2007/11

DOI： 10.1007/s11604-007-0169-8 　

ISSN： 0288-2043

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PURPOSE: The aim of this study was to evaluate the usefulness of periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER)-based diffusion tensor fiber tractography (DTT) at 3T to visualize infratentorial small fiber structures that cannot be visualized adequately using a conventional single shot echo planar imaging (ssEPI)-based pulse sequence. MATERIALS AND METHODS: Four healthy male volunteers were examined in this study. Diffusion tensor images were acquired on a 3T clinical magnetic resonance scanner using PROPELLER and echo planar imaging sequences in six motion-probing gradient orientations. Fiber tracking results for the trigeminal and auditory nerves were compared quantitatively. RESULTS: The trigeminal nerve tract was successfully reconstructed using both acquisition methods (100%). Among these reconstructed tracts, 62.5% of the tracts on PROPELLER-DTT and 25% on ssEPI-DTT were followed to branches beyond the trigeminal ganglion. The reconstructed auditory nerve tract could be identified on PROPELER-DTT (62.5%), whereas no tract or only a short tract was obtained on ssEPI-DTT (37.5%). CONCLUSION: 3T PROPELLER-DTT is useful for visualizing infratentorial small neurofiber structures.
Optic radiation tractography integrated into simulated treatment planning for Gamma Knife surgery. International-journal

Keisuke Maruyama, Kyousuke Kamada, Masahiro Shin, Daisuke Itoh, Yoshitaka Masutani, Kenji Ino, Masao Tago, Nobuhito Saito

Journal of neurosurgery　107　(4)　721-6　2007/10

ISSN： 0022-3085

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OBJECT: No definitive method of preventing visual field deficits after stereotactic radiosurgery for lesions near the optic radiation (OR) has been available so far. The authors report the results of integrating OR tractography based on diffusion tensor (DT) magnetic resonance imaging into simulated treatment planning for Gamma Knife surgery (GKS). METHODS: Data from imaging studies performed in 10 patients who underwent GKS for treatment of arteriovenous malformations (AVMs) located adjacent to the OR were used for the simulated treatment planning. Diffusion tensor images performed without the patient's head being secured by a stereotactic frame were used for DT tractography, and the OR was visualized by means of software developed by the authors. Data from stereotactic 3D imaging studies performed after frame fixation were coregistered with the data from DT tractography. The combined images were transferred to a GKS treatment-planning workstation. Delivered doses and distances between the treated lesions and the OR were analyzed and correlated with posttreatment neurological changes. RESULTS: In patients presenting with migraine with visual aura or occipital lobe epilepsy, the OR was located within 11 mm from AVMs. In a patient who developed new quadrantanopia after GKS, the OR had received 32 Gy. A maximum dose to the OR of less than 12 Gy did not cause new visual field deficits. A maximum dose to the OR of 8 Gy or more was significantly related to neurological change (p < 0.05), including visual field deficits and development or improvement of migraine. CONCLUSIONS: Integration of OR tractography into GKS represents a promising tool for preventing GKS-induced visual disturbances and headaches. Single-session irradiation at a dose of 8 Gy or more was associated with neurological change.
Diffusion tensor tractography for dose-planning of radiotherapy

青木茂樹, 増谷佳孝, 椛澤宏之, 丸山啓介, 鎌田恭輔, 井野賢司

臨床放射線　52　(8)　992-995　2007/08
Publisher:
ISSN： 0009-9252
Functional identification of the primary motor area by corticospinal tractography. International-journal

Kamada Kyousuke, Sawamura Yutaka, Takeuchi Fumiya, Kawaguchi Hideaki, Kuriki Shinya, Todo Tomoki, Morita Akio, Masutani Yoshitaka, Aoki Shigeki, Kirino Takaaki

Neurosurgery　61　(1 Suppl)　166-76; discussion 176-7　2007/07

DOI： 10.1227/01.neu.0000279213.23010.cb 　

ISSN： 1524-4040

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For quick and stable identification of the primary motor area (PMA), diffusion tensor imaging (DTI) data were acquired and corticospinal tractography was mathematically visualized.Data sets of DTI, anatomic magnetic resonance imaging, and functional magnetic resonance imaging with finger-tapping tasks were acquired during the same investigation in 30 patients with a brain lesion affecting the motor system. Off-line processing of DTI data was performed to visualize the corticospinal tract, placing a seed area in the cerebral peduncle of the midbrain, where the corticospinal tract is densely concentrated. Somatosensory evoked magnetic fields and intraoperative cortical somatosensory evoked potentials were recorded with electrical stimulation of the median nerve to confirm the results of the corticospinal tractography.Functional magnetic resonance imaging and somatosensory evoked magnetic fields failed to identify the PMA in eight patients (16.7%) and one patient (3.8%) investigated, respectively, because of cortical dysfunctions caused by brain lesions. DTI data were acquired within 3 minutes without patient tasks. Using the appropriate seed area and fractional anisotropy, corticospi
X線CT像における高精度気管支領域抽出のための信号値/サイズ分布の計測と解析 Peer-reviewed

渡邉雄一, 増谷佳孝, 野村行弘, 吉川健啓, 林直人, 吉川宏起, 佐藤昌憲, 大友邦

MEDICAL IMAGING TECHNOLOGY　25　(Suppl.)　B1-2　2007/07
Publisher: 日本医用画像工学会
ISSN： 0288-450X
表面情報による誤検出削減処理を用いた曲率に基づく肺結節の自動検出 Peer-reviewed

野村行弘, 伊藤治彦, 前田恵理子, 増谷佳孝, 吉川健啓, 林直人, 大友邦

MEDICAL IMAGING TECHNOLOGY　25　(Suppl.)　B1-4　2007/07
Publisher: 日本医用画像工学会
ISSN： 0288-450X
Shape based automated detection of pulmonary nodules with surface feature based false positive reduction Peer-reviewed

Yukihiro Nomura, Haruhiko Itoh, Eriko Maeda, Yoshitaka Masutani, Takeharu Yoshikawa, Naoto Hayashi, Kuni Ohtomo

INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY　2　S355-S357　2007/06

ISSN： 1861-6410

eISSN： 1861-6429
A Hybrid Tensor Field Interpolation Approach for White Matter Fiber Tract Modeling Peer-reviewed

Y. Masutani, S. Aoki, Z. Liu, O. Abe, K. Ohtomo

INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY　2　S22-S24　2007/06

ISSN： 1861-6410

eISSN： 1861-6429
A rod matrix compensator for small-field intensity modulated radiation therapy: A preliminary phantom study Peer-reviewed

Keiichi Nakagawa, Kiyoshi Yoda, Yoshitaka Masutani, Katsutake Sasaki, Kuni Ohtomo

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING　54　(5)　943-946　2007/05

DOI： 10.1109/TBME.2007.893490 　

ISSN： 0018-9294
Magnetic resonance diffusion tractography in the brain - Its application and limitation Peer-reviewed

Shigeki Aoki, Yoshitaka Masutani, Osamu Abe

Brain and Nerve　59　(5)　467-476　2007/05

ISSN： 0006-8969
[Magnetic resonance diffusion tractography in the brain--its application and limitation]. Peer-reviewed

Aoki S, Masutani Y, Abe O

Brain and nerve = Shinkei kenkyu no shinpo　59　(5)　467-476　2007/05

ISSN： 1881-6096
Primary face motor area as the motor representation of articulation. Peer-reviewed

Terao Y, Ugawa Y, Yamamoto T, Sakurai Y, Masumoto T, Abe O, Masutani Y, Aoki S, Tsuji S

Journal of neurology　254　(4)　442-447　2007/04

DOI： 10.1007/s00415-006-0385-7 　

ISSN： 0340-5354
Visualization of the frontotemporal language fibers by tractography combined with functional magnetic resonance imaging and magnetoencephalography Peer-reviewed

Kyousuke Kamada, Tomoki Todo, Yoshitaka Masutani, Shigeki Aoki, Kenji Ino, Akio Morita, Nobuhito Saito

JOURNAL OF NEUROSURGERY　106　(1)　90-98　2007/01

DOI： 10.3171/jns.2007.106.1.90 　

ISSN： 0022-3085
Flexible ex vivo phantoms for validation of diffusion tensor tractography on a clinical scanner. Peer-reviewed

Makoto Watanabe, Shigeki Aoki, Yoshitaka Masutani, Osamu Abe, Naoto Hayashi, Tomohiko Masumoto, Harushi Mori, Hiroyuki Kabasawa, Kuni Ohtomo

Radiation medicine　24　(9)　605-9　2006/11

DOI： 10.1007/s11604-006-0076-4 　

ISSN： 0288-2043

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PURPOSE: The aim of this study was to develop ex vivo diffusion tensor (DT) flexible phantoms. MATERIALS AND METHODS: Materials were bundles of textile threads of cotton, monofilament nylon, rayon, and polyester bunched with spiral wrapping bands and immersed in water. DT images were acquired on a 1.5-Tesla clinical magnetic resonance scanner using echo planar imaging sequences with 15 motion probing gradient directions. DT tractography with seeding and a line-tracking method was carried out by software originally developed on a PC-based workstation. RESULTS: We observed relatively high fractional anisotropy on the polyester phantom and were able to reconstruct tractography. Straight tracts along the bundle were displayed when it was arranged linearly. It was easy to bend arcuately or bifurcate at one end; and tracts followed the course of the bundle, whether it was curved or branched and had good agreement with direct visual observation. Tractography with the other fibers was unsuccessful. CONCLUSION: The polyester phantom revealed a diffusion anisotropic structure according to its shape and would be utilizable repeatedly under the same conditions, differently from living central neuronal system. It would be useful to validate DT sequences and to optimize an algorithm or parameters of DT tractography software. Additionally, the flexibility of the phantom would enable us to model human axonal projections.
[Diffusion tensor tractography of stroke: three dimensional relationship, quantitative analysis using FA and probability mapping of the pyramidal tract]. Peer-reviewed

Shigeki Aoki, Osamu Abe, Yoshitaka Masutani, Hiroyuki Kabasawa, Akira Kunimatsu

Nihon rinsho. Japanese journal of clinical medicine　64 Suppl 7　350-4　2006/10/28

ISSN： 0047-1852
Precise diffusion anisotropy measurement at crossing fiber from sparsely sampled diffusion MRI data set by using RBF based tensor field reconstruction Peer-reviewed

Hiroyuki Kabasawa, Yoshitaka Masutani, Osamu Abe, Shigeki Aoki, Kuni Ohtomo

International Journal of Computer Assisted Radiology and Surgery　1　(SUPPL. 7)　475-476　2006/06

ISSN： 1861-6410

eISSN： 1861-6429
Statistical modeling of white matter fiber tract based on diffusion MRI and its application for automated tractography Peer-reviewed

Y. Masutani, S. Aoki, O. Abe, K. Ohtomo

International Journal of Computer Assisted Radiology and Surgery　1　(SUPPL. 7)　467-468　2006/06

ISSN： 1861-6410

eISSN： 1861-6429
Liver CT image processing: A short introduction of the technical elements Peer-reviewed

Y. Masutani, K. Uozumi, Masaaki Akahane, Kuni Ohtomo

EUROPEAN JOURNAL OF RADIOLOGY　58　(2)　246-251　2006/05

DOI： 10.1016/j.ejrad.2005.11.044 　

ISSN： 0720-048X
Voxel-based diffusion tensor analysis reveals aberrant anterior cingulum integrity in posttraumatic stress disorder due to terrorism. International-journal Peer-reviewed

Abe O, Yamasue H, Kasai K, Yamada H, Aoki S, Iwanami A, Ohtani T, Masutani Y, Kato N, Ohtomo K

Psychiatry research　146　(3)　231-242　2006/04/03
Publisher: 3
DOI： 10.1016/j.pscychresns.2006.01.004 　

ISSN： 0165-1781

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Recent functional neuroimaging work has suggested that interregional functional connectivity between the anterior cingulate cortex (ACC), other limbic, and prefrontal regions may be involved in the pathophysiology of posttraumatic stress disorder (PTSD). However, less attention has been paid to the white matter network. Voxel-based analysis enables an exploration of morphological or functional changes throughout the entire brain. Here we undertook the first application of this technology to diffusion tensor data in patients with PTSD. Participants were 9 victims of the Tokyo subway sarin attack with PTSD and 16 matched victims of the same traumatic event without PTSD. The voxel-based analysis showed a significant fractional anisotropy increase in the left anterior cingulum, subjacent to the left ACC gray matter where we previously found a volume decrement, in PTSD subjects. Moreover, the severity was positively, but not significantly associated with the fractional anisotropy of the left anterior cingulum in the victims with PTSD, using the region of interest defined in the native space with the inverse normalization technique. The present study demonstrated further evidence of abnormalities of both the ACC, a structure that is pivotally involved in attention, emotional regulation, and fear conditioning, and of subjacent white matter in the pathology of PTSD.
Voxel-based diffusion tensor analysis reveals aberrant anterior cingulum integrity in posttraumatic stress disorder due to terrorism Peer-reviewed

Osamu Abe, Hidenori Yamasue, Kiyoto Kasai, Haruyasu Yamada, Shigeki Aoki, Akira Iwanami, Toshiyuki Ohtani, Yoshitaka Masutani, Nobumasa Kato, Kuni Ohtomo

Psychiatry Research - Neuroimaging　146　(3)　231-242　2006/04

DOI： 10.1016/j.pscychresns.2006.01.004 　

ISSN： 0925-4927
A neurosurgery navigation system with capability of intraoperative fiber tracking: Feasibility study Peer-reviewed

M. Watanabe, Y. Masutani, S. Aoki, K. Kamada, O. Abe, N. Hayashi, H. Mori, K. Ohtomo

International Journal of Computer Assisted Radiology and Surgery　1　(7)　487　2006
Publisher: Springer Verlag
DOI： 10.1007/s11548-006-0034-8 　

ISSN： 1861-6429 1861-6410
Model-based tractography based on statistical atlas of MR-DTI Peer-reviewed

Yoshitaka Masutani, Shigeki Aoki, Osamu Abe, Kuni Ohtomo

2006 3RD IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: MACRO TO NANO, VOLS 1-3　89-+　2006

ISSN： 1945-7928
[In-vitro phantoms for estimating diffusion tensor tractography]. Peer-reviewed

Makoto Watanabe, Yoshitaka Masutani, Shigeki Aoki, Harushi Mori, Osamu Abe, Naoto Hayashi, Tomohiko Masumoto, Haruyasu Yamada, Takeharu Yoshikawa, Hiroyuki Kabasawa, Kuni Ohtomo

Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica　65　(4)　449-51　2005/10

ISSN： 0048-0428

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No literature has reported on in-vitro diffusion tensor tractography, although it is a useful method to visualize neuronal fiber projections in the living human brain. We applied this technique to phantoms of asparagus stems and bundled polyester yarn, and obtained tractography with high-quality images. On the asparagus stem phantom, straight tracts along the axis were displayed. On the polyester phantom, these tracts followed the course of the bundle whether it was straight or curved. These phantoms are useful for in-vitro evaluation of diffusion tensor tractography.
Functional monitoring for visual pathway using real-time visual evoked potentials and optic-radiation tractography Peer-reviewed

K Kamada, T Todo, A Morita, Y Masutani, S Aoki, K Ino, K Kawai, T Kirino

NEUROSURGERY　57　(1)　121-126　2005/07

DOI： 10.1227/01.NEU.0000163526.60240.B6 　

ISSN： 0148-396X
Quantitative evaluation of the pyramidal tract segmented by diffusion tensor tractography: feasibility study in patients with amyotrophic lateral sclerosis. Peer-reviewed

Aoki S, Iwata NK, Masutani Y, Yoshida M, Abe O, Ugawa Y, Masumoto T, Mori H, Hayashi N, Kabasawa H, Kwak S, Takahashi S, Tsuji S, Ohtomo K

Radiation medicine　23　(3)　195-199　2005/05

ISSN： 0288-2043
Integration of three-dimensional corticospinal tractography into treatment planning for gamma knife surgery Peer-reviewed

K Maruyama, K Kamada, M Shin, D Itoh, S Aoki, Y Masutani, M Tago, T Kirino

JOURNAL OF NEUROSURGERY　102　(4)　673-677　2005/04

DOI： 10.3171/jns.2005.102.4.0673 　

ISSN： 0022-3085
Combined use of tractography-integrated functional neuronavigation and direct fiber stimulation Peer-reviewed

K Kamada, T Todo, Y Masutani, S Aoki, K Ino, T Takano, T Kirino, N Kawahara, A Morita

JOURNAL OF NEUROSURGERY　102　(4)　664-672　2005/04

DOI： 10.3171/jns.2005.102.4.0664 　

ISSN： 0022-3085
Corticospinal tract and corticobulbar tract dysfunction in ALS: combined study using transcranial magnetic stimulation and diffusion tensor tractography Peer-reviewed

Nobue K. Iwata, Shigeki Aoki, Yoshitaka Masutani, Mariko Yoshida, Shingo Okabe, Noritoshi Arai, Yasuo Terao, Shin Kwak, Shoji Tsuji, Yoshikazu Ugawa

International Congress Series　1278　181-184　2005/03

DOI： 10.1016/j.ics.2004.11.101 　

ISSN： 0531-5131
Partially uncrossed pyramidal tracts shown by tractography in horizontal gaze palsy and scoliosis Peer-reviewed

H Mori, T Fijishiro, N Hayashi, Y Masutani, S Aoki, K Ohtomo, M Aihara, M Wakakura

AMERICAN JOURNAL OF ROENTGENOLOGY　184　(3)　S4-S6　2005/03

ISSN： 0361-803X
Functional identification of the primary motor area by corticospinal tractography Peer-reviewed

Kyousuke Kamada, Yutaka Sawamura, Fumiya Takeuchi, Hideaki Kawaguchi, Shinya Kuriki, Tomoki Todo, Akio Morita, Yoshitaka Masutani, Shigeki Aoki, Takaaki Kirino

Neurosurgery　56　(1)　S-98-S-108　2005/01

DOI： 10.1227/01.NEU.0000144311.88383.EF 　

ISSN： 0148-396X
White matter fiber tract modeling based on reconstruction of fiber orientation vector field in DT-MRI Peer-reviewed

Y Masutani, S Aoki, O Abe, K Ino, K Ohtomo

CARS 2005: COMPUTER ASSISTED RADIOLOGY AND SURGERY　1281　1289-1289　2005

DOI： 10.1016/j.ics.2005.03.284 　

ISSN： 0531-5131
Diffusion tensor tractography of gliomatosis cerebri - Fiber tracking through the tumor Peer-reviewed

H Akai, H Mori, S Aoki, Y Masutani, N Kawahara, J Shibahara, K Ohtomo

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY　29　(1)　127-129　2005/01

ISSN： 0363-8715
Erratum: Diffusion property following functional hemispherectomy in hemimegalencephaly (Acta Radiologica (2004) 45 (778-781))

H. Mori, S. Aoki, O. Abe, N. Hayashi, Y. Masutani, K. Ohtomo, S. Oya, A. Morita

Acta Radiologica　45　779　2004/12/01

DOI： 10.1109/AFGR.2004.1301629 　

ISSN： 0284-1851
Diffusion property following functional hemispherectomy in hemimegalencephaly

H Mori, S Aoki, O Abe, N Hayashi, Y Masutani, K Ohtomo, S Oya, A Morita

ACTA RADIOLOGICA　45　(7)　778-781　2004/11

DOI： 10.1080/02841850410001303 　

ISSN： 0284-1851
[Principles of diffusion-weighted MR imaging and application to clinical neurology]. Peer-reviewed

Okubo T, Aoki S, Abe O, Masutani Y, Ohtomo K, Hori M, Ishigame K, Araki T

Rinsho shinkeigaku = Clinical neurology　44　(11)　954-956　2004/11
Publisher: 11
ISSN： 0009-918X
Amyotrophic lateral sclerosis: diffusion tensor tractography and voxel-based analysis International-journal Peer-reviewed

Abe O, Yamada H, Masutani Y, Aoki S, Kunimatsu A, Yamasue H, Fukuda R, Kasai K, Hayashi N, Masumoto T, Mori H, Soma T, Ohtomo K

NMR IN BIOMEDICINE　17　(6)　411-416　2004/10

DOI： 10.1002/nbm.907 　

ISSN： 0952-3480
Periodically rotated overlapping parallel lines with enhanced reconstruction-based diffusion tensor imaging. Comparison with echo planar imaging-based diffusion tensor imaging. Peer-reviewed

Abe O, Mori H, Aoki S, Kunimatsu A, Hayashi N, Masumoto T, Yamada H, Masutani Y, Kabasawa H, Ohtomo K

Journal of computer assisted tomography　28　(5)　654-660　2004/09

DOI： 10.1097/01.rct.0000138008.85349.28 　

ISSN： 0363-8715
Topography of the human corpus callosum using diffusion tensor tractography Peer-reviewed

Abe O, Masutani Y, Aoki S, Yamasue H, Yamada H, Kasai K, Mori H, Hayashi N, Masumoto T, Ohtomo K

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY　28　(4)　533-539　2004/07

DOI： 10.1097/00004728-200407000-00016 　

ISSN： 0363-8715
The optimal trackability threshold of fractional anisotropy for diffusion tensor tractography of the corticospinal tract. Peer-reviewed

Kunimatsu A, Aoki S, Masutani Y, Abe O, Hayashi N, Mori H, Masumoto T, Ohtomo K

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine　3　(1)　11-17　2004/04/01
Publisher: 1
DOI： 10.2463/mrms.3.11 　

ISSN： 1347-3182 1880-2206

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Purpose: In order to ensure that three-dimensional diffusion tensor tractography (3D-DTT) of the corticospinal tract (CST), is performed accurately and efficiently, we set out to find the optimal lower threshold of fractional anisotropy (FA) below which tract elongation is terminated (trackability threshold). Methods: Thirteen patients with acute or early subacute ischemic stroke causing motor deficits were enrolled in this study. We performed 3D-DTT of the CST with diffusion tensor MR (magnetic resonance) imaging. We segmented the CST and established a cross-section of the CST in a transaxial plane as a region of interest. Thus, we selectively measured the FA values of the right and left corticospinal tracts at the level of the cerebral peduncle, the posterior limb of the internal capsule, and the centrum semiovale. The FA values of the CST were also measured on the affected side at the level where the clinically relevant infarction was present in isotropic diffusion-weighted imaging. Results: 3D-DTT allowed us to selectively measure the FA values of the CST. Among the 267 regions of interest we measured, the minimum FA value was 0.22. The FA values of the CST were smaller and more variable in the centrum semiovale than in the other regions. The mean minus twice the standard deviation of the FA values of the CST in the centrum semiovale was calculated at 0.22 on the normal unaffected side and 0.16 on the affected side. Conclusion: An FA value of about 0.20 was found to be the optimal trackability threshold.
Visualization of central nervous system nerve communications using diffusion tensor imaging

H. Mori, Y. Masutani, O. Abe, S. Aoki, N. Hayashi, T. Masumoto, T. Yoshikawa, H. Yamada, K. Ohtomo

Rivista di Neuroradiologia　17　135-144　2004/01/01

DOI： 10.1177/197140090401700201 　

ISSN： 1120-9976
Three-dimensional white matter tractography by diffusion tensor imaging in ischaemic stroke involving the corticospinal tract

A Kunimatsu, S Aoki, Y Masutani, O Abe, H Mori, K Ohtomo

NEURORADIOLOGY　45　(8)　532-535　2003/08

DOI： 10.1007/s00234-003-0974-4 　

ISSN： 0028-3940
MR diffusion tensor imaging: recent advance and new techniques for diffusion tensor visualization Peer-reviewed

Y Masutani, S Aoki, O Abe, N Hayashi, K Otomo

EUROPEAN JOURNAL OF RADIOLOGY　46　(1)　53-66　2003/04

DOI： 10.1016/S0720-048X(02)00328-5 　

ISSN： 0720-048X
典型的な片側大脳萎縮を来たしたgerminoma-脳生検におけるfibertracking(tractography)の有用性が確認された1例

高橋美和子, 森墾, 増谷佳孝, 青木茂樹, 阿部修, 林直人, 増本智彦, 吉川健啓, 國松聡, 山田晴耕, 渡辺慎, 大友邦, 飯島明, 森田明夫

日本医学放射線学会雑誌　63　(4)　183-183　2003/03
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
Analysis of the white matter fibers by Diffusion tensor tractography : preliminary clinical experience

AOKI Shigeki, MASUTANI Yoshitaka, ABE Osamu, KUNIMATSU Satoshi, MORI Harushi, YAMADA Haruyasu, INO Kenji

Jap J Med VR　2　(1)　35-42　2003
Publisher: Japanese Society for Medical Virtual Reality
DOI： 10.7876/jmvr.2.35 　

ISSN： 1347-9342

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Diffusion of the water molecule in the brain is restricted by the white matter fibers. Tensor analysis of the proper diffusion-weighted data set provides quantitative analysis of the white matter diffusion anisotropy as well as fiber tracking (tractography) of the white matter. Preliminary clinical experience of diffusion tensor tractography was assessed.
EPI distortion correction for MR-DTI by using texture memory on graphics hardware Peer-reviewed

Y Masutani, T Yoshikawa, S Aoki, K Ohtomo, A Sherbondy, S Napel

CARS 2003: COMPUTER ASSISTED RADIOLOGY AND SURGERY, PROCEEDINGS　1256　1315-1315　2003

DOI： 10.1016/S0531-5131(03)00286-3 　

ISSN： 0531-5131
[Simple visualization of the corticospinal pathway using tractography: one-ROI and two-ROI methods]. Peer-reviewed

Harushi Mori, Yoshitaka Masutani, Shigeki Aoki, Osamu Abe, Naoto Hayashi, Tomohiko Masumoto, Haruyasu Yamada, Takeharu Yoshikawa, Akira Kunimatsu, Kuni Ohtomo, Hiroyuki Kabasawa

Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica　63　(1)　51-3　2003/01
Publisher: 1
ISSN： 0048-0428

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Diffusion tensor imaging (DTI), a magnetic resonance (MR) technique to analyze diffusion anisotropy of the brain, is able to demonstrate subtle white matter anatomy. Tractography is expected to be a unique, non-invasive tool to provide more pertinent insights into brain structure and orientation not accessible by conventional MRI. In this report, preliminary experiences of visualization of the corticospinal tract using tractography are described. DTI of the brain was performed in 5 normal volunteers using single-shot echo-planar imaging, then tractography was generated by our original software. We determined that the two-region-of-interest (ROI) method is superior to the one-ROI method.
Evaluation of the crossing fiber trajectory through the corpus callosum using diffusion tensor tractography Peer-reviewed

Abe O, Masutani Y, Yamasue H, Aoki S, Yamada H, Ohtomo K

RADIOLOGY　225　281　2002/11

DOI： 10.1097/00004728-200407000-00016 　

ISSN： 0033-8419
PROPELLER MRIがvariant Creutzfeldt-Jakob病の否定に役立った1例

森墾, 林直人, 青木茂樹, 増谷佳孝, 阿部修, 増本智彦, 吉川健啓, 國松聡, 山田晴耕, 齊藤公章, 佐竹芳朗, 渡辺靖志, 後藤政実, 大友邦, 平川美菜子, 宇川義一, 椛沢宏之, 塚元鉄二, 平田直樹

日本医学放射線学会雑誌　62　(10)　558-558　2002/09
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
[Evaluation of PROPELLER MR imaging: preliminary experiences]. Peer-reviewed

Harushi Mori, Shigeki Aoki, Osamu Abe, Yoshitaka Masutani, Tomohiko Masumoto, Naoto Hayashi, Takeharu Yoshikawa, Yasushi Watanabe, Yoshirou Satake, Kuni Ohtomo, Hiroyuki Kabasawa

Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica　62　(6)　287-9　2002/05

ISSN： 0048-0428

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Periodically Rotated Overlapping ParallEL Lines with Enhanced Reconstruction (PROPELLER) MR imaging (MRI) has a unique ability to correct motion artifacts and is expected to be useful in diffusion-weighted MRI. This article describes preliminary experiences with PROPELLER MRI. PROPELLER uses a radial scan variation of the fast spin-echo sequence and it shows much less spatial deterioration than the echo-planar imaging sequence. To determine the optimal parameters of this technique, we calculated the signal intensities of phantoms and brains in various settings. PROPELLER MR examinations were also performed in 66 patients for clinical use. PROPELLER MRI appears to be a promising and useful technique.
A case of restless patient successfully performed by PROPELLER MRI; a promising and useful technique for motion correction

Harushi Mori, N. Hayashi, S. Aoki, O. Abe, Y. Masutani, K. Ohtomo, M. Hirakawa, Y. Ugawa

Japanese Journal of Clinical Radiology　47　(11)　1629-1632　2002/01/01

ISSN： 0009-9252
Three-dimensional slice image overlay system with accurate depth perception for surgery Peer-reviewed

K Masamune, Y Masutani, S Nakajima, Sakuma, I, T Dohi, H Iseki, K Takakura

MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2000　1935　395-402　2000

DOI： 10.1007/978-3-540-40899-4_40 　

ISSN： 0302-9743
Augmented reality visualization system for intravascular neurosurgery Peer-reviewed

Yoshitaka Masutani, Takeyoshi Dohi, Fumitaka Yamane, Hiroshi Iseki, Kintomo Takakura

Computer Aided Surgery　3　(5)　239-247　1998
Publisher: John Wiley and Sons Inc.
DOI： 10.1002/(SICI)1097-0150(1998)3:5<239::AID-IGS3>3.3.CO;2-2 　

ISSN： 1092-9088
Interactive virtualized display system for intravascular neurosurgery

Yoshitaka Masutani, Takeyoshi Dohi, Fumitaka Yamane, Hiroshi Iseki, Kintomo Takakura

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)　1205　427-435　1997
Publisher: Springer Verlag
DOI： 10.1007/bfb0029265 　

ISSN： 1611-3349 0302-9743
Volumegraph (Overlaid three-dimensional image-guided navigation) - Clinical application of augmented reality in neurosurgery Peer-reviewed

H Iseki, Y Masutani, M Iwahara, T Tanikawa, Y Muragaki, T Taira, T Dohi, K Takakura

STEREOTACTIC AND FUNCTIONAL NEUROSURGERY　68　(1-4)　18-24　1997

ISSN： 1011-6125
Three-dimensional image-guided navigation with overlaid three-dimensional image (volumegraph) and volumetric ultrasonogram (V-US) Peer-reviewed

H Iseki, N Hata, Y Masutani, M Iwahara, T Ono, H Kataoka, K Masamune, T Dohi, K Takakura

COMPUTER-ASSISTED NEUROSURGERY　123-130　1997
3D position visualization of catheter tip for intravascular neurosurgery using 3D structural description of vasculature Peer-reviewed

Y Masutani, C Furukawa, M Sonderegger, K Masamune, M Suzuki, T Dohi, F Yamane, H Iseki, K Takakura

CAR '96: COMPUTER ASSISTED RADIOLOGY　1124　821-826　1996

ISSN： 0531-5131
Preoperative simulation of neurosurgical operations using three dimensional optical solid model: Laser lithography plastic replica Peer-reviewed

T Taira, H Iseki, K Masamune, E Kobayashi, Y Masutani, M Suzuki, T Dohi, K Takakura

CAR '96: COMPUTER ASSISTED RADIOLOGY　1124　1059-1059　1996

ISSN： 0531-5131
Vision based registration of medical manipulator for stereotactic neurosurgery Peer-reviewed

K Masamune, Y Masutani, S Hayashida, M Suzuki, T Dohi, H Iseki, K Takakura

CAR '96: COMPUTER ASSISTED RADIOLOGY　1124　1050-1050　1996

ISSN： 0531-5131
Development of an endoscope manipulator system for laparoscopic surgery Peer-reviewed

Y Koseki, K Masamune, H Kataoka, Y Masutani, M Suzuki, T Dohi, D Hashimoto

CAR '96: COMPUTER ASSISTED RADIOLOGY　1124　1049-1049　1996

ISSN： 0531-5131
Region-growing based feature extraction algorithm for tree-like objects Peer-reviewed

Y Masutani, K Masamune, T Dohi

VISUALIZATION IN BIOMEDICAL COMPUTING　1131　161-171　1996

DOI： 10.1007/BFb0046951 　

ISSN： 0302-9743
Quantitative vascular shape analysis for 3D MR-angiography using mathematical morphology

Yoshitaka Masutani, Tsuyoshi Kurihara, Makoto Suzuki, Takeyoshi Dohi

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)　905　449-454　1995
Publisher: Springer Verlag
DOI： 10.1007/978-3-540-49197-2_58 　

ISSN： 1611-3349 0302-9743
Development of an MRI-compatible needle insertion manipulator for stereotactic neurosurgery Peer-reviewed

Ken Masamune, Etsuko Kobayashi, Yoshitaka Masutani, Makoto Suzuki, Takeyoshi Dohi, Hiroshi Iseki, Kintomo Takakura

Computer Aided Surgery　1　(4)　242-248　1995
Publisher: Informa Healthcare
DOI： 10.3109/10929089509106330 　

ISSN： 1092-9088
Development of an MRI‐compatible needle insertion manipulator for stereotactic neurosurgery Peer-reviewed

Ken Masamune, Etsuko Kobayashi, Yoshitaka Masutani, Makoto Suzuki, Takeyoshi Dohi, Hiroshi Iseki, Kintomo Takakura

Journal of Image Guided Surgery　1　(4)　242-248　1995

DOI： 10.1002/(SICI)1522-712X(1995)1:4<242::AID-IGS7>3.0.CO;2-A 　

ISSN： 1522-712X 1078-7844
Computer Aided Surgery (CAS) System for Stereotactic Neurosurgery. Peer-reviewed

Yoshitaka Masutani, Ken Masamune, Makoto Suzuki, Takeyoshi Dohi, Hiroshi Iseki, Kintomo Takakura

Computer Vision, Virtual Reality and Robotics in Medicine, First International Conference, CVRMed'95, Nice, France, April 3-6, 1995, Proceedings　247-251　1995
Publisher: Springer
DOI： 10.1007/978-3-540-49197-2_29 　
Study on high speed vessel model reconstruction from MRI:Study on high speed vessel model reconstruction from MRI

MASUTANI Yoshitaka, SUZUKI Makoto, OIITA Yuji, HORIUCHI Takashi, DOHI Takeyoshi

Journal of Life Support Engineering　4　(3)　116-123　1992
Publisher: THE SOCIETY OF LIFE SUPPORT ENGINEERING
DOI： 10.5136/lifesupport1986.4.3_116 　

ISSN： 0912-1595

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A lot of data are required to reconstruct3D vessel model for therapentic and diagnoitic purposes such as surgery simulation, surgical planning and computer aided surgery system . In this study, new methods for reconstruction were developped to reduce data volume and cumbersome procedure. Concerning the vessel model reconstruction, the positions and the radi of vascular sections are extracted on MR-Images, and relations of connection between the sections were generated. A vessel model was represented by spheres and truncated cones. Feasibility study were carried out using MR-Images derived from two phantoms and four human volunteers.
対話型血管モデリングシステムの研究

増谷佳孝, 土肥健純

エル・エス・ティ学会誌　3　(4)　144-145　1991
Publisher: THE SOCIETY OF LIFE SUPPORT ENGINEERING
DOI： 10.5136/lifesupport1986.3.144 　

ISSN： 0912-1595

Show all ︎Show first 5

Misc. 388

Latest Research Trends 2023: neurobrain area and diffusion MRI

増谷佳孝, 一関雄輝

電子情報通信学会技術研究報告(Web)　123　(411(MI2023 30-89))　2024

ISSN： 2432-6380
Report on MICCAI 2022

伊東隼人, 小田昌宏, 小田昌宏, SHEN Chen, WANG Cheng, 三浦幹太, 佐藤淳哉, 大竹義人, 備瀬竜馬, 古川亮, 本谷秀堅, 増谷佳孝, 森健策, 森健策, 森健策, 森健策

電子情報通信学会技術研究報告(Web)　122　(417(MI2022 72-130))　2023

ISSN： 2432-6380
HCP data processing by hybrid approach for parameter inference in free water imaging model of diffusion MRI-comparison of diffusion tensor computation methods for datasets without b0 image-

増谷佳孝, 山崎奎吾, 内田航, 鎌形康司, 佐々木公, 青木茂樹

電子情報通信学会技術研究報告(Web)　123　(96(MI2023 7-13))　2023

ISSN： 2432-6380
Development and Spread of Diffusion MRI Analysis Software

増谷佳孝, 青木茂樹, 阿部修, 堀正明, 大友邦

Medical Imaging Technology (Web)　41　(3)　2023

ISSN： 2185-3193
Comparison of Two Approaches for Diffusional Kurtosis Inference : Synthetic Q-space Learning and DWI Denoising [Presidential Award Proceedings]

佐々木公, 岩部ななせ, 増谷佳孝

日本磁気共鳴医学会雑誌　42　(2)　2022

ISSN： 0914-9457
Evaluation of Diffusional Kurtosis Inference Using Synthetic q-space Learning and Bias Correction

佐々木公, 増谷佳孝, 木下佳祐, 野中春輝, 廣川裕

日本放射線技術学会雑誌　78　(6)　2022

ISSN： 0369-4305
Quantitative Evaluation of Least-Squares Fitting Biases for Improvement of Diffusional Kurtosis Inference by Synthetic Q-space Learning

佐々木公, 増谷佳孝

医用画像情報学会雑誌(Web)　39　(3)　2022

ISSN： 1880-4977
Comparison of PCA and NMF in construction of 2.5D SSM for meniscus

縄手就矢, 増谷佳孝, 北村直幸

日本医用画像工学会大会予稿集(CD-ROM)　40th　2021

ISSN： 0288-450X
Development of Intuitive Medical Image Display System with Multi-Touch LCD

増谷佳孝, 出羽貴之, 藤川拓馬, 見澤勇太

日本医用画像工学会大会予稿集(CD-ROM)　39th　2020

ISSN： 0288-450X
Report on MICCAI 2019

小田昌宏, 伊東隼人, 宮内翔子, 諸岡健一, 松崎博貴, 花岡昇平, 古川亮, 増谷佳孝, 森健策, 森健策

電子情報通信学会技術研究報告　119　(399(MI2019 65-123)(Web))　2020

ISSN： 0913-5685
新たなwebベースの統合的CAD開発プラットフォームの構築

野村行弘, 三木聡一郎, 林直人, 花岡昇平, 吉川健啓, 増谷佳孝, 阿部修

電子情報通信学会技術研究報告　118　(412(MI2018 59-115)(Web))　2019

ISSN： 0913-5685
Diffusion MRI (1): Overview and Signal Models

増谷佳孝

Medical Imaging Technology (Web)　37　(2)　2019

ISSN： 2185-3193
Diffusion MR Imaging and Signal Models for Biological Structure Inference

増谷佳孝

計測と制御　58　(7)　2019

ISSN： 0453-4662
Step up MRI 2019 最新技術の研究開発・臨床応用から展望するMRIの未来 II MRIの最新技術と未来展望-基礎編 3.拡散MRIにおけるディープラーニングの活用-信号値モデルのパラメータ推定を中心に

増谷佳孝, 佐々木公

Innervision　34　(9)　2019

ISSN： 0913-8919
拡散テンソルトラクトグラフィへの応用のためのフィザルムソルバの拡張

増谷佳孝

日本応用数理学会年会講演予稿集(CD-ROM)　2019　2019

ISSN： 1345-3378
Generalizing Demons Algorithm and Its Application

増谷佳孝, 石田善喜

Medical Imaging Technology (Web)　37　(4)　2019

ISSN： 2185-3193
生成型Q空間学習による拡散MRイメージング

増谷佳孝

日本医用画像工学会大会予稿集(CD-ROM)　38th　2019

ISSN： 0288-450X
拡散尖度撮像法のパラメタ推定のための生成型Q空間学習における最適雑音量の自動決定に向けて

内濱良介, 河野智奈美, 佐々木公, 佐々木公, 増谷佳孝

日本医用画像工学会大会予稿集(CD-ROM)　38th　2019

ISSN： 0288-450X
Report on MICCAI 2017

大竹義人, 伊藤康一, 小田昌宏, 備瀬竜馬, 諸岡健一, ZHOU Xiangrong, 斉藤篤, 清水昭伸, 増谷佳孝, 佐藤嘉伸, 森健策

電子情報通信学会技術研究報告　117　(518(MI2017 63-106))　2018

ISSN： 0913-5685
画像電子技術の医療分野における応用(3)拡散MRIの発展と近年の動向

増谷佳孝

画像電子学会誌(CD-ROM)　47　(2)　2018

ISSN： 2186-716X
Deep Regressionによる拡散MRIの各種モデルパラメタ推定~生成型学習データの分布が及ぼす影響について~

増谷佳孝, 佐々木公, 佐々木公

電子情報通信学会技術研究報告　118　(150(MI2018 21-31)(Web))　2018

ISSN： 0913-5685
Demonsアルゴリズムの一般化とその応用

増谷佳孝, 石田善喜

日本医用画像工学会大会予稿集(CD-ROM)　37th　2018

ISSN： 0288-450X
医工連携と教育研究:広島における取り組み

増谷佳孝

日本生体医工学会大会プログラム・抄録集(Web)　57th　2018
Deep Regression Neural Networkによる拡散MRIの信号値モデルパラメタの推定:合成データのみによる学習における学習パラメタの効果

増谷佳孝, 佐々木公

日本医学放射線学会秋季臨床大会抄録集　54th　2018

ISSN： 0048-0428
Comparing Methods for Fiber-Radial Signal Decay Reconstruction by Q-Space Data Interpolation and Line Integral in Diffusion MRI

増谷佳孝, 佐々木公, 佐々木公

電子情報通信学会技術研究報告　117　(117)　23-26　2017/07/06
Publisher: 電子情報通信学会
ISSN： 0913-5685
Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's disease cases

Naganawa Shinji, Kishimoto Toshifumi, Yasuno Fumihiko, Matsuoka Kiwamu, Nakane Toshiki, Kawai Hisashi, Masutani Yoshitaka, Taoka Toshiaki

Japanese Journal of Radiology　35　(4)　172-178　2017/04
Publisher: Springer
ISSN： 1867-1071
Report on MICCAI 2016

小田昌宏, 宮内翔子, 諸岡健一, 周向栄, 増谷佳孝, 中口俊哉, 井宮淳, 森健策

電子情報通信学会技術研究報告 = IEICE technical report : 信学技報　116　(393)　185-190　2017/01/18
Publisher: 電子情報通信学会
ISSN： 0913-5685
加振下の変形挙動に着目したフレッシュコンクリートの粘性の評価

西村和朗, 増谷直輝, 加藤佳孝

セメント技術大会講演要旨(CD-ROM)　71st　2017
Glymphatic system評価に向けて:DTI analysis along Perivascular Space(DTI-ALPS)でのAlzheimer病例の検討

田岡俊昭, 増谷佳孝, 川井恒, 中根俊樹, 長縄慎二

日本神経放射線学会プログラム・抄録集　46th　2017
造影CT画像における点群入力に基づく腸間膜の3次元形状推定と再構成について

増谷佳孝, 阿原一志, 鈴木宗村, 植田琢也

電子情報通信学会技術研究報告　117　(117(MI2017 25-36))　2017

ISSN： 0913-5685
逐次選択法を用いた特徴量の決定に基づく肺結節自動検出

青山正人, 片山玄汰, 藤原久志, 増谷佳孝

日本医用画像工学会大会予稿集(CD-ROM)　36th　2017

ISSN： 0288-450X
オンライン転移学習を用いた脳動脈瘤検出ソフトウェアの性能改善

野村行弘, 佐藤一誠, 佐藤一誠, 花岡昇平, 三木聡一郎, 吉川健啓, 林直人, 阿部修, 増谷佳孝

電子情報通信学会技術研究報告　117　(220(MI2017 37-46))　2017

ISSN： 0913-5685
Time to check CAD results

S. Miki, N. Hayashi, Y. Nomura, Y. Masutani

American Journal of Neuroradiology　37　(12)　E81　2016/12/01
Publisher: American Society of Neuroradiology
DOI： 10.3174/ajnr.A4941 　

ISSN： 1936-959X 0195-6108
Four-Dimensional Cone-Beam CT Iterative Reconstruction with Time-Ordered Chain Graph Model for Non-Periodic Organ Motion and Deformation

M. Nakano, A. Haga, J. Kotoku, T. Magome, Y. Masutani, S. Hanaoka, K. Nakagawa

MEDICAL PHYSICS　43　(6)　3702-3702　2016/06

DOI： 10.1118/1.4957236 　

ISSN： 0094-2405

eISSN： 2473-4209
拡散MRIのQ空間データにおける補間および線積分に基づく線維方向およびその垂直方向の拡散尖度の計算方法

増谷佳孝, 佐々木公, 佐々木公

電子情報通信学会技術研究報告　116　(298(MI2016 62-70))　2016

ISSN： 0913-5685
MRI measurement of water diffusion in living body and its application for inferring anatomical structures

増谷佳孝

電子情報通信学会技術研究報告　116　(344(SIS2016 28-41))　2016

ISSN： 0913-5685
拡散MRI解析の基礎

増谷佳孝

医学物理 Supplement　36　(2)　2016

ISSN： 1345-5362
UTH CAD Challenge2015プロジェクト現況報告

野村行弘, 増谷佳孝, 工藤俊介, 中口俊哉, 澤田好秀, 北村凱平, 青山正人, 花岡昇平, 中尾貴祐, 三木聡一郎, 根本充貴, 吉川健啓, 林直人

日本医用画像工学会大会予稿集(CD-ROM)　35th　2016

ISSN： 0288-450X
Tracking left ventricle in cardiac 4D CT images.-comparison between DP matching and Demons algorithm-

松本尚, 青山正人, 増谷佳孝, 山本秀也, 木原康樹

電子情報通信学会技術研究報告　115　(301(MI2015 57-72))　15‐18　2015/11/04

ISSN： 0913-5685
腰痛症における椎間板変性のdiffusional kurotosis imaging解析

高野弘充, 青木茂樹, 米澤郁穂, 堀正明, 桂正樹, 増谷佳孝, 錦織瞭, 奥田貴俊, 嶋村之利, 吉川慶, 佐藤達哉, 金子和夫

日本整形外科学会雑誌　89　(8)　S1618-S1618　2015/09
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
Evolution of Computer vision and Evolution of Medical Image Recognition and Understanding : Panel discussion

本谷秀堅, 増谷佳孝, 佐藤嘉伸, 清水昭伸, 森健策

電子情報通信学会技術研究報告　115　(139)　27-32　2015/07/14
Publisher: 電子情報通信学会
ISSN： 0913-5685
骨盤領域に対するtime-ordered 4次元コーンビームCT再構成(Time-ordered Four Dimensional Cone-beam CT Reconstruction for Pelvic Region)

Nakano Masahiro, Kida Satoshi, Masutani Yoshitaka, Imae Toshikazu, Yamamoto Kentaro, Shiraishi Kenshiro, Nakagawa Keiichi, Haga Akihiro

日本放射線影響学会大会講演要旨集　58回　4-04　2015/05
Publisher: (一社)日本放射線影響学会
ISSN： 1347-8680
Total variation regularization of diffusion weighted images for reducing noise of diffusional kurtosis MRI

Nakamura Yuuki, Okada Hirokuni, Aoyama Masahito, Masutani Yoshitaka

IEICE technical report.　114　(482)　205-208　2015/03/02
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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Diffusional kurtosis imaging (DKI) is an MR imaging method for quantifying non-Gaussianity of water molecule based on a set of diffusion weighted images (DWI) of several magnitude of motion probing gradient. It is observed that noise in DWI causes pepper-like noise on subsequent kurtosis images by computation error. We aimed at reduction of the computation error by using total variation (TV) regularization of the set of DW. By using a synthetic data set and a clinical brain data set of a healthy volunteer, we confirmed the effect of TV regularization.
Interactive organ region segmentation method based on the input of the fuzzy boundary information

MATSUMOTO Takashi, TOMIOKA Yoshiki, AOYAMA Masahito, MASUTANI Yoshitaka

IEICE technical report.　114　(482)　233-236　2015/03/02
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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In this paper, we propose an interactive and semi-automated organ segmentation method for 3D medical images. First, fragments of organ boundary are drawn on arbitrary section images displayed in a touch panel device. Second, true boundary points and their normal are automatically estimated based on image features, and then interactive elimination of points of estimation error is performed. Finally, by using the boundary point coordinates and normal, the target shape is reconstructed as a volumetric image based on radial basis functions. In this study, we examined the method by using 5 CT datasets for liver segmentation, and obtained an average correspondence rate of 81.85% with gold standard volume obtained by manual input.
Imaging position recognition of CT images using deep learning for computational medical image understanding

Noshiro Fumiyasu, Aoyama Masahito, Masutani Yoshitaka

IEICE technical report.　114　(482)　143-146　2015/03/02
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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In this paper, we describe our method based on deep learning and majority voting for imaging position recognition, which can be the first step of computational medical image understanding. The problem is classification of 4 classes of positions; head, chest, abdomen, and pelvis for axial sections of X-ray CT images. To collect large quantities of various training data, we used keyword search on the internet. First, in our method, small patches randomly extracted from training data sets are used for training convolutional neural network. Next, small patches are extracted from test image in the similar way and individual classification results are obtained for the patches. Finally, majority voting is performed for obtaining the final classification result. In the experiment by using 724 training images and 361 test images, we obtained 94% of classification accuracy.
An interim report on UTH CAD Challenge 2014 : Preliminary study for training and temporal evaluation of CAD software in clinical environment

NOMURA Yukihiro, MASUTANI Yoshitaka, KUDO Shunsuke, UEHARA Takahiro, HIRANO Ryoji, NAKAGUCHI Toshiya, HANAOKA Shouhei, NEMOTO Mitsutaka, MIKI Soichiro, YOSHIKAWA Takeharu, HAYASHI Naoto, OHTOMO Kuni

IEICE technical report.　114　(482)　317-320　2015/03/02
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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Computer-assisted detection/diagnosis (CAD) software has been developed by many research groups, and commercial CAD software has also been released. However, most radiologists have not yet utilized CAD software in daily practice. Possible cause includes the difference of data characteristics, such as imaging hardware and imaging protocols, between in developmental and in practical environments. However, it is difficult for many research groups to have a dataset of significant quantity and quality in their research environment, because of the issue of the personal information protection. Hence, it is desired to build an in-hospital environment for supervised learning and evaluation of CAD software. We have implemented the collaborative research project for training and evaluation of CAD software in other institutions (UTH CAD Challenge) since August 2014. In this short report, we described overview of the project and reported interim results of UTH CAD Challenge 2014.
腰痛症における椎間板変性のDiffusional Kurtosis Imaging解析

高野弘充, 青木茂樹, 米澤郁穂, 堀正明, 桂正樹, 増谷佳孝, 錦織瞭, 奥田貴俊, 嶋村之利, 吉川慶, 佐藤達哉, 金子和夫

Journal of Spine Research　6　(3)　306-306　2015/03
Publisher: (一社)日本脊椎脊髄病学会
ISSN： 1884-7137

eISSN： 2435-1563
腰痛症における椎間板変性のdiffusional kurotosis imaging解析

高野弘充, 青木茂樹, 米澤郁穂, 堀正明, 桂正樹, 増谷佳孝, 錦織瞭, 奥田貴俊, 嶋村之利, 吉川慶, 金子和夫

日本整形外科学会雑誌　89　(3)　S637-S637　2015/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
計算機による医用画像理解を目的とした解剖学的構造物のモデリング

増谷佳孝

日本放射線技術学会総会学術大会予稿集　71st　2015

ISSN： 1884-7846
Improvement of Kilo-voltage Cone Beam CT Image Quality with Iterative Optimized Scatter Correction Algorithm

木田智士, 増谷佳孝, 中野正寛, 今江禄一, 中川恵一, 芳賀昭弘

Medical Imaging Technology (Web)　33　(3)　2015

ISSN： 2185-3193
読影疲労測定に有用な疲労指標の検索

吉川健啓, 林直人, 増谷佳孝, 赤羽正章, 吉岡直紀, 大友邦, 小森悠矢, 中島亮一, 横澤一彦, 前田恵理子, 前田恵理子

Japanese Journal of Radiology　33　(Supplement)　2015

ISSN： 1867-1071
Lung tumor motion reproducibility for five patients who received four-fraction VMAT stereotactic ablative body radiotherapy under constrained breathing conditions: a preliminary study

Keiichi Nakagawa, Akihiro Haga, Katsutake Sasaki, Satoshi Kida, Yoshitaka Masutani, Hideomi Yamashita, Wataru Takahashi, Hiroshi Igaki, Akira Sakumi, Kuni Ohtomo, Kiyoshi Yoda

JOURNAL OF RADIATION RESEARCH　55　(6)　1199-1201　2014/11

DOI： 10.1093/jrr/rru055 　

ISSN： 0449-3060

eISSN： 1349-9157
拡散MRIを用いた脳腫瘍におけるtissue characterizationの試み：各組織の拡散定量値のvoxel-by-voxel study

JAPANESE JOURNAL OF MAGNETIC RESONANCE IN MEDICINE　34　350-350　2014/09

ISSN： 0914-9457
多発性硬化症の視路におけるDiffusional kurtosis imagingを用いた拡散解析視覚誘発電位との検討

吉田茉莉子, 堀正明, 小菅正嗣, 横山和正, 神谷昂平, 鎌形康司, 鈴木通真, 鈴木由里子, 青木茂樹, 増谷佳孝, 服部信孝

日本磁気共鳴医学会雑誌　34　(1)　32-32　2014/02
Publisher: (一社)日本磁気共鳴医学会
ISSN： 0914-9457
Random-forest based spatial normalization using anatomical landmarks from CT images with unknown FOV

KIKUCHI Kazuma, OKADA Toshiyuki, HANAOKA Shohei, MASUTANI Yoshitaka, HORI Masatoshi, TOMIYAMA Noriyuki, SATO Yoshinobu

IEICE technical report.　113　(410)　169-173　2014/01/26
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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We have proposed the fully automated multi-organ segmentation using computational anatomy model from abdominal CT images. However, this method cannot apply to CT data with different field of view (FOV) due to the spatial normalization based on assumption that the FOV of CT image is upper abdomen. In this paper, we propose a method for spatial normalization using anatomical landmarks from CT images with unknown FOV. Given a number of anatomical landmarks, the parameters of the bounding box which determines the normalization space are estimated using random forest. The proposed method was evaluated by comparing the segmentation accuracy using spatial normalization with known FOV. The experimental results using 35 thoracoabdominal CT images showed that the performance of the proposed method was comparable to the segmentation using spatial normalization with known FOV.
撮像条件や解析手法の相違が各種拡散定量値に与える影響

堀正明, 鎌形康司, 吉田茉莉子, 鈴木通真, 増谷佳孝, 神谷昂平, 熊谷文孝, 朝日公一, 中西淳, 青木茂樹

日本神経放射線学会プログラム・抄録集　43rd　2014
医用画像に基づく計算解剖学の創成と診断・治療支援の高度化 VI 計算解剖学:ワーキンググループ(WG)からの報告-国際シンポジウムの報告も含めて

森健策, 清水昭伸, 増谷佳孝, 増谷佳孝, 佐藤嘉伸, 佐藤嘉伸

Innervision　29　(11)　2014

ISSN： 0913-8919
医用画像に基づく計算解剖学の創成と診断・治療支援の高度化 II 計算解剖学基礎:計画班からの報告 1.計算解剖学の基礎数理

増谷佳孝, 増谷佳孝, 本谷秀堅, 松添博, 井宮淳

Innervision　29　(11)　2014

ISSN： 0913-8919
Q ball imaging tractographyを用いた脳腫瘍手術

齊藤邦昭, 武笠晃丈, 鈴木雄一, 井野賢司, 大谷亮平, 高柳俊作, 田中將太, 國松聡, 増谷佳孝, 大友邦, 齊藤延人

日本脳腫瘍学会学術集会プログラム・抄録集　32nd　2014
Development, Clinical Use, Continuous Performance Improvement of CAD Software Based on Multi-institutional Collaboration in Teleradiology Environment

野村行弘, 増谷佳孝, 三木聡一郎, 花岡昇平, 根本充貴, 吉川健啓, 林直人, 大友邦

Medical Imaging Technology (Web)　32　(2)　2014

ISSN： 2185-3193
ラット脳梗塞モデルにおける拡散尖度の経時的変化

田岡俊昭, 藤岡政行, 柏木雄人, 小幡篤史, 六川武美, 阿部浩司, 堀正明, 増谷佳孝, 青木茂樹, 吉川公彦

日本神経放射線学会プログラム・抄録集　43rd　136　2014
Pilot study of anatomical landmark detection adapted to change of body posture

NEMOTO Mitsutaka, MASUTANI Yoshitaka, HANAOKA Shouhei, NOMURA Yukihiro, MIKI Soichiro, YOSHIKAWA Takeharu, HAYASHI Naoto, OHTOMO Kuni

IEICE technical report.　113　(219)　5-10　2013/09/13
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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We have been studying automatic detection method for multiple anatomical landmarks (LMs) from human torso CT. In the detection targets, some LMs which have the wide variation of local appearance depending on the change of body posture are included and are difficult to detect. For example, the local appearances of acromion, tip of the coracoid process, and inferior tip of scapula are changed depending on arm position. Our previous LM detection process was trained without consideration for the change of LM local appearance from the body posture, and did not have sufficient performance for those LMs. In this study, LM candidate (LMC) detection and LMC classification, both of which are trained with dataset from specific body postural CT data such as lowered arm posture and lifted arm posture, are proposed to improve the LMC detection / classification performances. Experimental results showed the proposed method had better detection and classification performance than the previous method.
Comparison of sparse non-directional graphical models on anatomical landmark distances by the Smoothly Clipped Absolute Deviation (SCAD) and the Graphical Lasso

Hanaoka Shouhei, Masutani Yoshitaka, Nemoto Mitsutaka, Nomura Yukihiro, Miki Soichiro, Yoshikawa Takeharu, Hayashi Naoto, Ohtomo Kuni

IEICE technical report.　113　(146)　7-12　2013/07/18
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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We have been developed an automatic detection system for anatomical landmarks in CT images. The system utilizes a multivariable Gaussian statistical model on inter-landmark distances which were estimated with Tikhonov or L1-norm regularization terms. The aim of this study is to introduce a novel SCAD regularization term to our landmark detection system. In the experimental result, the SCAD-based method showed almost the same result as L1 norm-based method. However, the former showed more robustness against parameter change than the latter method
On Uncertainty of Anatomical Landmarks and Their Detectability by using Appearance Models

MASUTANI Yoshitaka, NEMOTO Mitsutaka, HANAOKA Shohei, HAYASHI Naoto, OHTOMO Kuni

IEICE technical report.　113　(146)　13-16　2013/07/18
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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The anatomical landmarks are defined at local structures with salient features such as projections on bones or bifurcations of blood vessels, and play key roles in computational understanding of medical images. However, there exist uncertainty on landmark point definition due to local similarity of surrounding appearance. We have been working on the quantification of landmark uncertainty and validated with clinical data sets. In this study, we report on the experimental results for comparison of landmark uncertainty their detectability.
Clinical machine learning in action: CAD system design, development, tuning, and long-term experience Peer-reviewed

Yoshitaka Masutani, Mitsutaka Nemoto, Yukihiro Nomura, Naoto Hayashi

Image Processing: Concepts, Methodologies, Tools, and Applications　2-3　621-638　2013/05/31
Publisher: IGI Global
DOI： 10.4018/978-1-4666-3994-2.ch032 　
q Space Imaging and Diffusional Kurtosis Imaging: Basics and Clinical Applications

堀正明, 鎌形康司, 吉田茉莉子, 増谷佳孝, 鈴木由里子, 青木茂樹

画像診断　33　(7)　731-742　2013/05
Publisher: (株)学研メディカル秀潤社
DOI： 10.15105/J00235.2013245955 　

ISSN： 0285-0524

eISSN： 2432-1281
【脊椎脊髄の解剖と疾患】 (第2章)知っておくと役立つ特殊検査 MRI 拡散画像

堀正明, 白神伸之, 増谷佳孝, 鎌形康司, 吉田茉莉子, 青木茂樹

脊椎脊髄ジャーナル　26　(4)　413-419　2013/04
Publisher: (株)三輪書店
ISSN： 0914-4412
脳脊髄における各種拡散計算値へのライス分布ノイズ除去フィルターの効果

堀正明, 鎌形康司, 吉田茉莉子, 下地啓五, 中西淳, 濱崎望, 佐藤秀二, 鈴木由里子, 増谷佳孝, 青木茂樹

日本医学放射線学会総会抄録集　72nd　S370-S370　2013/02/28
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
Variational Computation of Mean Shape

INAGAKI Shun, IMIYA Atsushi, HONTANI Hidekata, HANAOKA Shouhei, MASUTANI Yoshitaka

Technical report of IEICE. PRMU　112　(441)　143-148　2013/02/21
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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In this paper, we develop a variational method for the computation of average images of biological organs in three-dimensional Euclidean space. The average of three-dimensional biological organs is an essential feature to discriminate normal organs from abnormal organs. We combine the diffusion registration technique and optical flow computation for the computation of spatial deformation field between the averages and each input organ. We define the average as the shape which minimises the total deformation.
Diffusional Kurtosis Imagingを用いた特発性正常圧水頭症における術前後の白質微細構造の検討

中西淳, 福永一星, 堀正明, 増谷佳孝, 濱崎望, 佐藤秀二, 中島円, 宮嶋雅一, 新井一, 青木茂樹

日本医学放射線学会学術集会抄録集　72回　S256-S256　2013/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
急性期脳梗塞白質病変におけるDiffusion Tensor ImagingとDiffusional Kurtosis Imaging

斎藤史根, 福永一星, 朝日公一, 鈴木通真, 堀正明, 京極伸介, 磯野沙智子, 卜部貴夫, 増谷佳孝, 青木茂樹

日本医学放射線学会学術集会抄録集　72回　S257-S257　2013/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
A pilot study of lung voxel classification for auto-detecting ground glass opacity nodules in chest CT images

NEMOTO Mitsutaka, MASUTANI Yoshitaka, HANAOKA Shouhei, NOMURA Yukihiro, MIKI Soichiro, YOSHIKAWA Takeharu, HAYASHI Naoto, OHTOMO Kuni

IEICE technical report.　112　(411)　245-248　2013/01/24
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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In this study, we examine various voxel classification methods for auto-extracting ground glass opacity (GGO) nodule candidates. Classifiers evaluating experimentally are two types of one-class classifier (threshold functions of a Mahalanobis distance and a norm of residue by embedding in a manifold trained by Isomap), and two kinds of two-class classifier (a threshold function of Mahalanobis distance ratio and a classifier ensemble trained by AdaBoost). In addition to evaluate the classifiers individually, four cascade classifiers each of which are combination of an initial rejection by the one-class classifier and a following classification by the two-class classifier are also validated experimentally. The evaluation results show the cascade classifier has a potential for providing the voxel classification results to extract GGO nodule candidates with high performance.
Construction of probability model for radiologists' detection failures in a routine reading environment

NOMURA Yukihiro, MASUTANI Yoshitaka, NEMOTO Mitsutaka, HANAOKA Shouhei, MIKI Soichiro, YOSHIKAWA Takeharu, HAYASHI Naoto, OHTOMO Kuni

IEICE technical report.　112　(411)　305-310　2013/01/24
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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In order to realize CAD display interfaces based on radiologists' reading characteristics, it is important to construct probability model of reading characteristics in routine reading environment. In this short report, we constructed a probability model for radiologists' detection failures based on feedback data collected in screening lung CT in a routine reading environment integrated with CAD software by using kernel density estimation. Constructed model enabled radiologists to understand their own characteristics of image reading in more detail.
Improvement of 4D Cone-beam CT image quality via iterative reconstruction method

KIDA Satoshi, MASUTANI Yoshitaka, NAKANO Masahiro, IMAE Toshikazu, HAGA Akihiro

IEICE technical report.　112　(411)　73-75　2013/01/24
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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Cone-beam computed tomography (CBCT) is a major online imaging modality for image-guided radiotherapy (IGRT) and improvement of CBCT image quality can contribute to detect accurate localization of target and administrate treatment dose. However, image quality of CBCT is superior to Fan beam CT, and this image degradation limits the accuracy of localization of target and make dose calculation on the CBCT images difficult. Four-dimensional cone beam CT (4D-CBCT) is also well known as powerful modality for IGRT. Conventionally, it is reconstructed by sorting the X-ray projection images into each respiratory phase according to a breathing signal using the FDK algorithm. This usually leads to inadequate number of projections in each phase, resulting in low quality 4D-CBCT images with obvious streaking artifacts. We tried to improve the image quality for 4D CBCT using iterative reconstruction method (ML-convex) and compared with the images by FDK in SNR of the reconstructed images.
Construction of a sparse non-directional graphical model on anatomical landmark distances by the Graphical Lasso : Feasibility study for application to automatic landmark detection system

Hanaoka Shouhei, Masutam Yoshitaka, Nemoto Mitsutaka, Nomura Yukihiro, Miki Soichiro, Yoshikawa Takeharu, Hayashi Naoto, Ohtomo Kuni

IEICE technical report.　112　(411)　13-18　2013/01/24
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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We have been developed an automatic detection system for anatomical landmarks in CT images. The system utilizes a non-sparse multivariable Gaussian statistical model on inter-landmark distances. The aim of this study is to extend our previous method to sparse multivariable Gaussian model by GPGPU-implemented Graphical lasso method. The probabilistic distribution of inter-landmark distances was estimated as a multiple Gaussian distribution with a sparse precision matrix. Feasibility of improvement of the landmark detection accuracy with this novel inter-landmark distance model was evaluated.
Variational Mean of Biological Organs

INAGAKI Shun, IMIYA Atsushi, HONTANI Hidekata, HANAOKA Shouhei, MASUTANI Yoshitaka

IEICE technical report.　112　(411)　1-6　2013/01/24
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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In this paper, we develop a variational method for the computation of average images of biological organs in three-dimensional Euclidean space. The average of three-dimensional biological organs is an essential feature to discriminate normal organs from abnormal organs. We combine the diffusion registration technique and optical flow computation for the computation of spatial deformation field between the averages and each input organ. We define the average as the shape which minimises the total deformation.
Report on MICCAI 2012

Hirano Yasushi, Nakaguchi Toshiya, Hanaoka Shohei, Masutani Yoshitaka, Shimizu Akinobu, Kitasaka Takayuki, Oda Masahiro, Mon Kensaku, Sawada Yoshihide, Hontani Hidekata, Sato Yoshinobu, Furukawa Daisuke, Nakano Yuta

IEICE technical report.　112　(411)　323-328　2013/01/24
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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In this paper, the outline of each session of MICCAI 2012 main conference and several workshops in MICCAI 2012 are introduced. A few interesting reports in the conference are also introduced and explained
Anatomical landmark-based local deformation method for medical registration

森田景子, 井宮淳, 酒井智弥, 増谷佳孝, 本谷秀堅

電子情報通信学会技術研究報告　112　(411(MI2012 62-124))　161-166　2013/01/17

ISSN： 0913-5685
q-space解析におけるMPG印可時間,拡散時間との関連性

畑純一, 鈴木雄一, 國松聡, 佐々木弘喜, 増谷佳孝, 矢野敬一, 大友邦

日本放射線技術学会総会学術大会予稿集　69th　2013

ISSN： 1884-7846
拡散異方性可変線維ファントムを用いたQ-Space Imagingの初期検討

井野賢司, 増谷佳孝, 鈴木雄一, 伊藤賢司, 畑純一, 後藤政実, 矢野敬一

日本放射線技術学会総会学術大会予稿集　69th　2013

ISSN： 1884-7846
多発性硬化症のdiffusional kurtosis imaging:白質・灰白質のdouble inversion recovery併用による定量

吉田茉莉子, 堀正明, 横山和正, 福永一星, 京極伸介, 鈴木通真, 鎌形康司, 下地啓五, 中西淳, 鈴木由里子, 青木茂樹, 増谷佳孝

日本神経放射線学会プログラム・抄録集　42nd　2013
錐体路トラクトグラフィ併用皮質-白質モニタリングの有用性と限界-Diffusion tensor imagingとQ ball imagingの比較-

齊藤邦昭, 鈴木雄一, 井野賢司, 吉野正紀, 国松聡, 増谷佳孝, 大友邦, 田中將太, 武笠晃丈, 齊藤延人

日本脳腫瘍の外科学会プログラム・抄録集　18th　2013
Mathematical Models for Anatomical Landmarks and Point Distribution Representation of Anatomical Objects for Medical Image Understanding

増谷佳孝, 本谷秀堅, 井宮淳

Medical Imaging Technology (Web)　31　(5)　2013

ISSN： 2185-3193
臨床における統合的CAD開発環境の構築(第6報):再学習処理による施設毎のCAD性能改善

野村行弘, 増谷佳孝, 林直人, 三木聡一郎, 花岡昇平, 根本充貴, 吉川健啓, 大友邦

日本医学放射線学会総会抄録集　72nd　2013

ISSN： 0048-0428
Training strategy for performance improvement in computer-assisted detection of lesions based on multi-institutional study in teleradiology environment Peer-reviewed

Yukihiro Nomura, Yoshitaka Masutani, Soichiro Miki, Shouhei Hanaoka, Mitsutaka Nemoto, Takeharu Yoshikawa, Naoto Hayashi, Kuni Ohtomo

2013 FIRST INTERNATIONAL SYMPOSIUM ON COMPUTING AND NETWORKING (CANDAR)　320-322　2013

DOI： 10.1109/CANDAR.2013.57 　
Coarse-to-fine localization of anatomical landmarks in CT images based on multi-scale local appearance and rotation-invariant spatial landmark distribution model Peer-reviewed

Mitsutaka Nemoto, Yoshitaka Masutani, Shouhei Hanaoka, Yukihiro Nomura, Soichiro Miki, Takeharu Yoshikawa, Naoto Hayashi, Kuni Ohtomo

MEDICAL IMAGING 2013: IMAGE PROCESSING　8669　2013

DOI： 10.1117/12.2007134 　

ISSN： 0277-786X

eISSN： 1996-756X
Automatic detection method for anatomical landmarks on the soft tissue in enhanced abdominal CT volumes

Hanaoka Shouhei, Masutani Yoshitaka, Nomura Yukihiro, Nemoto Mitsutaka, Miki Soichiro, Yoshikawa Takeharu, Hayashi Naoto, Ohtomo Kuni

IEICE technical report.　112　(200)　7-12　2012/09/04
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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We have been developed an automatic detection system for anatomical landmarks in plain torso CT images. However, the system has a problem of low detection rate for soft-tissue landmarks. The aim of this study is to extend our previous method to contrast enhanced CT datasets. In our approach 17 soft-tissue landmarks are detected, together with several bone and lung landmarks simultaneously. The evaluation with 21 datasets showed a fair result of less than 70% of detection rate for 10 of 17 soft-tissue landmarks. Thus, we believe that our method is feasible to various soft-tissue landmarks in contrast enhanced, abdominal CT volumes.
【押さえておきたいMRIの基本とピットフォール】脊椎・脊髄の拡散強調像基本とピットフォール

堀正明, 白神伸之, 増谷佳孝, 福永一星, 鈴木由里子, 青木茂樹

脊椎脊髄ジャーナル　25　(9)　863-871　2012/09
Publisher: (株)三輪書店
ISSN： 0914-4412
Improvement of Cone-beam CT image quality and dose reduction via iterative reconstnuction method

KIDA Satoshi, HAGA Akihiro, MASUTANI Yoshitaka, SAOTOME Naoya, NAKANO Masahiro, SAKUMI Akira, YAMASHITA Hideomi, NAKAGAWA keiichi

IEICE technical report.　112　(200)　27-28　2012/08/28
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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Cone-beam computed tomography(CBCT) is a major online imaging modality for image-guided radiotherapy (IGRT)and improvement of CBCT image quality can contribute to detect accurate localization of target and administrate treatment dose. However,image quality of CBCT is superior to Fan beam CT, and this image degradation limits the accuracy of localization of target and make dose calculation on the CBCT images difficult. We attempted to improve the CBCT image quality and reduce exposed dose by acquiring CBCT with iterative reconstruction method.
Optimization for q-space Imaging in a Clinical Setting : Setting the q-value

HAMASAKI Nozomi, SATO Shuji, HORI Masaaki, FUKUNAGA Issei, KOSAKA Toru, ITO Kazunori, SUZUKI Yuriko, HOUSHITO Haruyoshi, MASUTANI Yoshitaka, AOKI Shigeki

32　(3)　85-93　2012/08/15
Publisher: (一社)日本磁気共鳴医学会
ISSN： 0914-9457
Preliminary study for undersampling non-lesion voxel in training of voxel-based calssification for lesion detection

NOMURA Yukihiro, NEMOTO Mitsutaka, MASUTANI Yoshitaka, HANAOKA Shouhei, MIKI Soichiro, YOSHIKAWA Takeharu, HAYASHI Naoto, OHTOMO Kumi

IEICE technical report.　112　(142)　59-64　2012/07/12
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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In voxel-based classification for lesion detection, training of a classifier is time-consuming since the number of training voxels is huge. Moreover, the number of non-lesion voxels is extremely larger than that of lesion voxels. So, it is important to reduce the number of non-lesion voxels for training. In this short report, we investigated relation between undersampling non-lesion voxels in training of voxel based classifier and detection accuracy by using cerebral aneurysm detection in MR angiograms. In the experimental study, it is desirable to train the classifier using all cases/voxels, but undersampling non-lesion voxels have potential to effective when time required for training is time-consuming or the number of training sample is excessive.
正常頸髄後索における各種拡散計算値の値は年齢,性別により変化するか?

堀正明, 青木茂樹, 福永一星, 鎌形康司, 下地啓五, 中西淳, 濱崎望, 佐藤秀二, 鈴木由里子, 増谷佳孝

日本医学放射線学会総会抄録集　71st　S362-S362　2012/02/29
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
多発性硬化症におけるDiffusional kurtosis imagingを用いた白質の定量解析

吉田茉莉子, 堀正明, 横山和正, 鎌形康司, 桑鶴良平, 笹井啓資, 青木茂樹, 増谷佳孝

日本医学放射線学会総会抄録集　71st　S195-S195　2012/02/29
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
Diffusion Kurtosis Imaging : Optimization of Parameters for Clinical Use

FUKUNAGA Issei, HORI Masaaki, MASUTANI Yoshitaka, HAMASAKI Nozomi, SATO Shuji, SUZUKI Yuriko, SHIMOJI Keigo, NAKANISHI Atsushi, AOKI Shigeki, SENOO Atsushi

日本磁気共鳴医学会雑誌　32　(1)　29-35　2012/02/15
Publisher: (一社)日本磁気共鳴医学会
ISSN： 0914-9457
q-space imagingによる、アルツハイマー病症例の鈎状束、および後部帯状束の解析

田岡俊昭, 坂本雅彦, 明石敏昭, 越智朋子, 和田敬, 堀正明, 青木茂樹, 増谷佳孝, 吉川公彦

日本医学放射線学会学術集会抄録集　71回　S195-S195　2012/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
Diffusional kurtosis imagingを用いた特発性正常圧水頭症の錐体路に関する検討

中西淳, 堀正明, 福永一星, 濱崎望, 増谷佳孝, 中島円, 宮嶋雅一, 新井一, 桑鶴良平, 青木茂樹

日本医学放射線学会学術集会抄録集　71回　S361-S361　2012/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
A pilot study of medical image texture analysis via manifold learning

NEMOTO Mitsutaka, MASUTANI Yoshitaka, HANAOKA Shouhei, NOMURA Yukihiro, YOSHIKAWA Takeharu, HAYASHI Naoto, OHTOMO Kuni

IEICE technical report.　111　(389)　355-358　2012/01/19
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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Manifold learning is a dimensionally reduction approach with a similarity between training sample in a feature space. There are various extensions of manifold learning and its application to medical image analysis is prosperous. In this study, we work on texture analysis of Ground Glass Opacity (GGO) in chest CT image as a primary study of texture analysis for medical images by manifold learning. Laplacian Eigenmap (LE) is used to non-linearly redact dimension of feature space constricting texture features calculated from a voxel, and usefulness to classification process of the obtained subspace is verified experimentally. Dimensionally reduction by LE is inspected through a distribution of projected training sample to the subspace and accuracy of classifying GGO and healthy lung tissues.
Simultaneous extraction of multiple organs using a combination of conditional statistical shape model and graph cuts

KAMIYAMA Junichi, TOMOSHIGE Sho, WATANABE Hidefumi, SHIMIZU Akinobu, KOBATAKE Hidefumi, NAWANO Shigeru, Nemoto Mitsutaka, HANAOKA Shohei, MASUTANI Yoshitaka

IEICE technical report.　111　(389)　299-304　2012/01/19
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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In the previous report, we proposed a multi-label graph-cuts based simultaneous segmentation algorithm for multiple organs which utilizes estimated shapes of organs. The performance of the shape estimation, however, is low in the case of gallbladder whose variation in shape and pose is large, resulting in poor performance of the graph-cuts based segmentation. This study proposes a conditional statistical shape model of an organ in which information correlated with the target organ is used as a condition. We aim to boost performance of shape estimation and organ segmentation by use of the proposed model. This paper presents results of applying the proposed model to simultaneous segmentation of neighboring four organs in a CT volume and report that the performance of the proposed model was superior to that of a conventional non-conditional model.
Accuracy improvement of the landmark detection system with a fast out-of-imaging-range LM position estimation algorithm

Hanaoka Shouhei, Masutani Yoshitaka, Nomura Yukihiro, Nemoto Mitsutaka, Miki Soichiro, Yoshikawa Takeharu, Hayashi Naoto, Ohtomo Kumi

IEICE technical report.　111　(389)　209-214　2012/01/19
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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We have been developed an automatic detection system for anatomical landmarks in torso CT images. However, the system has a problem of being instable given an image volume with relatively small imaging range. The aim of this study is to solve this problem by introducing a new fast algorithm for estimating the landmark point outside of the given imaging range. It enables the system to estimate an out-of-range landmark position candidate and to add it to the candidate list before each sampling. With this improvement, the system became more stable with volumes of small imaging range. The proposed algorithm was evaluated with clinical CT datasets.
MPG Reduction for Effective Diffusion MR Imaging Based on L1-norm Regularization

IWAMOTO Kazunari, HONTANI Hidekata, MASUTANI Yoshitaka

IEICE technical report.　111　(389)　35-40　2012/01/19
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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The high angular resolution diffusion imaging (HARDI) captures high angular-resolution 3D images of diffusion MR imaging by changing the direction of the motion probing gradient (MPG), along which the strength of water diffusion is mesured. The problem here is that the capturing process is time consuming when many MPGs are applied for making the angular resolution higher. In this article, we propose a method for decreasing the number of MPG directions with keeping the angular resolution higher. Limiting the target to pyramidal tracts, we obtain an optimal set of MPG directions that can realize high angular resolution with small number of the directions. For this purpose, we employ a spherical radial basis functions (SRBF) for interpolating the measurements and obtains the set of MPG directions by minimizing the residuals between the training measurements and the interpolated ones with sparseness regularization. The performance of the proposed method is demonstrated by simulation experiments and by clinical image ones.
Web-based CAD server for clinical use, evaluation, and incremental learning : Incremental learning of CAD software based on multicenter trial in teleradiology environment

NOMURA Yukihiro, MASUTANI Yoshitaka, HAYASHI Naoto, MIKI Soichiro, NEMOTO Mitsutaka, HANAOKA Shouhei, YOSHIKAWA Takeharu, OHTOMO Kuni

IEICE technical report.　111　(389)　23-28　2012/01/19
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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We have been building a web-based CAD server (CIRCUS CS) that enables radiologists to use CAD software and to give feedback in clinical environment. Collected feedback data enable us to improve performance of CAD software by incremental learning. The incremental learning in the clinical environment can play a key role in performance improvement when the modality data differ among hospitals or the modality is updated. In this short report, we investigated an incremental learning of CAD software based on multicenter trial in teleradiology environment. The simulation studies show that the performance indices were improved depending on the number of both additional TP cases and additional FP cases.
Comparison of Various Computation Methods in Diffusion Kurtosis Imaging and its Application to Atlas Construction

Masutani Yoshitaka, Aoki Shigeki

IEICE technical report.　111　(389)　41-46　2012/01/19
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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In diffusion kurtosis imaging (DKI) for quantifying the non-Gaussian motion of water molecule, several pairs of an imaging parameter; b value and measured signal; S(b) are used to approximate S(b) curve and DKI parameters such as diffusion kurtosis. Including our closed form expressions we have reported before, with which we can analytically obtain those parameters by least square fit, there exist several computing methods for DKI parameter computing. Those variations are characterized by number of used b values, S(0) estimation, outlier removal, etc., but no comparison was performed so far to clarify their advantages and disadvantages. In this report, we describe comparison results of 6 methods for DKI parameter determination by using rate of computation error, which is defined as deviation of a value range of a biophysical basis. In addition, we apply the best method among the six methods to construction of a diffusion MRI parameter atlas consists of statistics of diffusion anisotropy, diffusion coefficient, and diffusion kurtosis.
Improvement of Cone-beam CT image quality of radiation therapy

KIDA Satoshi, SAOTOME Naoya, HAGA Akihiro, MASUTANI Yoshitaka, NAKAGAWA Keiichi

IEICE technical report.　111　(389)　417-418　2012/01/12
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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Cone-beam computed tomography (CBCT) is a major online imaging modality for image-guided radiotherapy (IGRT) and improvement of CBCT image quality can contribute to detect accurate localization of target and administrate treatment dose. We calculate the scatter photon distribution using analytic model with Klein-Nishina formula and acquire scattered corrected reconstruction image.
Diffusional kurtosis imagingを用いた特発性正常圧水頭症の錐体路に関する検討

中西淳, 堀正明, 福永一星, 濱崎望, 増谷佳孝, 中島円, 宮嶋雅一, 新井一, 桑鶴良平, 青木茂樹

日本医学放射線学会総会抄録集　71st　2012

ISSN： 0048-0428
Diffusional kurtosis imagingを利用した特発性正常圧水頭症の錐体路に関する検討

中西淳, 堀正明, 下地啓五, 吉田茉莉子, 福永一星, 朝日公一, 増谷佳孝, 中島円, 宮嶋雅一, 新井一, 青木茂樹

日本神経放射線学会プログラム・抄録集　41st　2012
拡散異方性可変線維ファントム作成の試み

井野賢司, 増谷佳孝, 鈴木雄一, 伊藤賢司, 畑純一, 後藤政実, 矢野敬一

日本放射線技術学会総会学術大会予稿集　68th　2012

ISSN： 1884-7846
q-space解析における算出パラメータの差異評価

畑純一, 鈴木雄一, 國松聡, 佐々木弘喜, 増谷佳孝, 矢野敬一, 大友邦

日本放射線技術学会総会学術大会予稿集　68th　2012

ISSN： 1884-7846
Q-ball imaging tractographyとfMRIを併用した錐体路分離描出

鈴木雄一, 井野賢司, 後藤政実, 渡辺靖志, 矢野敬一, 大友邦, 増谷佳孝, 伊藤賢司, 國松聡, 赤羽正章, 丸山克也

日本放射線技術学会東京部会雑誌　(121)　2012

ISSN： 0916-9652
q-space imagingによる,アルツハイマー病症例の辺縁系回路のtract based解析

田岡俊昭, 坂本雅彦, 明石敏昭, 堀正明, 青木茂樹, 増谷佳孝, 打越将人, 木内邦明, 森川将行, 岸本年史, 吉川公彦

日本神経放射線学会プログラム・抄録集　41st　2012
拡散MRIの撮像時間短縮のための雑音を考慮したMPG削減

岩本和成, 本谷秀堅, 増谷佳孝

日本医用画像工学会大会予稿集(CD-ROM)　31st　2012

ISSN： 0288-450X
Q-ball imaging tractographyとfMRIを併用した錐体路分離描出

鈴木雄一, 増谷佳孝, 伊藤賢司, 井野賢司, 丸山克也, 後藤政実, 渡辺靖志, 國松聡, 國松聡, 赤羽正章, 赤羽正章, 矢野敬一, 大友邦, 大友邦

日本放射線技術学会東京部会雑誌　(122)　2012

ISSN： 0916-9652
放射線治療におけるCone-beam CTの画像改善

木田智士, 早乙女直也, 中野正寛, 芳賀昭弘, 増谷佳孝, 今江禄一, 作美明, 山下英臣, 中川恵一

医学物理 Supplement　32　(3)　2012

ISSN： 1345-5362
治療ビームを用いた画像再構成

芳賀昭弘, 橋本成世, 木田智士, 早乙女直也, 作美明, 伊藤さおり, 増谷佳孝, 今江禄一, 中川恵一

医学物理 Supplement　32　(3)　2012

ISSN： 1345-5362
Diffusion Tensor and Kurtosis Imagingを用いた特発性正常圧水頭症の検討

福永一星, 福永一星, 中西淳, 堀正明, 増谷佳孝, 濱崎望, 佐藤秀二, 服部高明, 中島円, 青木茂樹, 新井一, 宮嶋雅一, 妹尾淳史

日本正常圧水頭症学会プログラム・抄録集　13th (Web)　2012
類似度流による潜在的な解剖学的ランドマークの探索

増谷佳孝, 根本充貴, 花岡昇平, 林直人, 大友邦

日本医用画像工学会大会予稿集(CD-ROM)　31st　2012

ISSN： 0288-450X
Visualizing Non-Gaussian Diffusion: Clinical Application of q-Space Imaging and Diffusional Kurtosis Imaging of the Brain and Spine

Masaaki Hori, Issei Fukunaga, Yoshitaka Masutani, Toshiaki Taoka, Koji Kamagata, Yuriko Suzuki, Shigeki Aoki

MAGNETIC RESONANCE IN MEDICAL SCIENCES　11　(4)　221-233　2012

ISSN： 1347-3182
QSI/DKIの基礎と初期臨床応用

吉田茉莉子, 堀正明, 福永一星, 増谷佳孝, 中西淳, 下地啓五, 朝日公一, 鎌形康司, 横山和正, 鈴木通真, 濱崎望, 青木茂樹

日本神経放射線学会プログラム・抄録集　41st　110　2012
A pilot study of anatomical landmark detection from thick slice CT images

NEMOTO Mitsutaka, HANAOKA Shouhei, MASUTANI Yoshitaka, NOMURA Yukihiro, YOSHIKAWA Takeharu, HAYASHI Naoto, OHTOMO Kuni

IEICE technical report.　111　(331)　MI2011-71　2011/11/29
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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We have developed the automatically detection framework of anatomical landmarks (LMs) from a thin slice CT data. In the proposed framework, candidates of LM are detected from a whole body area by a PCA based appearance matching with a statistical appearance model of LM neighbor regions. However, thick slice CT images which only one direction (mainly a body axis direction) has extremely low resolution are also generally taken and read for diagnosis in clinical practices. It should be difficult to detect LM with high sensitivity from thick slice CT images by application to our previous detection method requiring the detailed spatial resolution of all three directions. In this study, a LM candidate detection method based on an axial-2D appearance matching which is newly proposed for detecting LMs from thick slice CT is statistically evaluated with virtual database of thick slice CT image.
Acceleration of boosting using GPU and speed evaluation of training by a huge amount of data

NEMOTO Mitsutaka, MASUTANI Yoshitaka, HANAOKA Shouhei, NOMURA Yukihiro, YOSHIKAWA Takeharu, HAYASHI Naoto, OHTOMO Kuni

IEICE technical report.　111　(331)　19-24　2011/11/29
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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Generally, use of a large quantity of learning data in a training of a classifier contributes to the performance enhancement of the classifier greatly. On the other hand, the increase of learning data causes increase of the learning time, and it is especially with a factor to drop speed of the study and the development. We attempted shortening of the learning time of AdaBoost which is one of the most favorite ensemble learning algorithms using parallel processing by GPU in this study. From an evaluation of the learning speed using a virtual learning data, the effectiveness of the parallel AdaBoost learning by GPU was described experimentally when the amount of learning data was in particular huge.
Statistical modeling of special landmark distribution : model building techniques for datasets with various imaging ranges

Hanaoka Shouhei, Masutani Yoshitaka, Nemoto Mitsutaka, Nomura Yukihiro, Miki Soichiro, Yoshikawa Takeharu, Hayashi Naoto, Ohtomo Kuni

IEICE technical report.　111　(331)　25-30　2011/11/29
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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In building a statistical shape model, each training dataset is implicitly required to have the enough imaging range which includes all organs of interest. However, this assumption may not be satisfied in modeling of the whole human body. In this study, we developed a novel method to build a special landmark distribution model from image datasets with partial and various imaging ranges. The EM algorithm was utilized to estimate the missing data in the given training datasets. The proposed algorithm was evaluated with 40 whole-torso CT datasets.
Connectivity Metric based on Local Appearance Similarity and Level-Set : toward quantitative evaluation of landmark uncertainty

Masutani Yoshitaka, HANAOKA Shouhei, Nemoto Mitsutaka, HAYASHI Naoto, OHTOMO Kuni

IEICE technical report.　111　(331)　55-60　2011/11/29
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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Anatomical landmarks play key roles in computational understanding of medical images, and are generally defined on a point with surrounding small regions of salient features, such as bone tip and soft tissue boundaries. When we detect such landmarks with appearance features, punctual determination is often hard depending on its surrounding image intensity structures. That is, there exists a kind of uncertainty for determination of landmarks with anisotropy. In this short paper, we first propose a measure for connectivity between two local appearances by using arrival time of level-set function controlled by the similarity among them, then utilize it for quantification of landmark uncertainty and its anisotropy. We performed several experiments by using synthetic data and clinical data.
Report on MICCAI 2011

NEMOTO Mitsutaka, MASUTANI Yoshitaka, SHIMIZU Akinobu, HONTANI Hidekata, HIRANO Yasushi, HANAOKA Shouhei, ODA Masahiro, XU Rui, FURUKAWA Daisuke, NAKANO Yuta, MORI Kensaku

IEICE technical report.　111　(331)　37-42　2011/11/22
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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In this paper, the outline of each session of MICC AI 2011 main conference and several workshops in MICCAI 2011 are introduced. A few interesting reports in the conference are also introduced and explained.
臨床と研究に役立つ最新のMRI学拡散MRIの臨床応用

青木茂樹, 堀正明, 増谷佳孝, 阿部修, 鎌形康司, 服部高明

臨床神経学　51　(11)　955-955　2011/11
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
Study of input voxel size on voxel-based classifier for lesion detection

NOMURA Yukihiro, NEMOTO Mitsutaka, MASUTANI Yoshitaka, HANAOKA Shouhei, MIKI Soichiro, YOSHIKAWA Takeharu, HAYASHI Naoto, OHTOMO Kuni

IEICE technical report　111　(199)　7-10　2011/08/30
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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To improve detection accuracy for small lesion, it is desirable that a resolution of original volume data should be as high as possible. However, resolution of clinical image is limited due to hardware limitation or size of imaging range. Volume upsampling by interpolation may be used instead of high resolution volume data. In this short report, we investigated relation between voxel size after interpolation and detection accuracy by using cerebral aneurysm detection in MR angiograms based on voxel based classifier. In the experimental study with 83 clinical cases, the results show that volume upsampling by interpolation have potential to improve detection accuracy for small lesion.
Improvement of vertebral segmentation accuracy by using anatomical landmark position information

HANAOKA Shouhei, MASUTANI Yoshitaka, NOMURA Yukihiro, NEMOTO Mitsutaka, MAEDA Eriko, YOSHIKAWA Takeharu, HAYASHI Naoto, OHTOMO Kumi

IEICE technical report　111　(199)　11-16　2011/08/30
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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A method to improve the segmentation accuracy of the vertebral body with use of information on anatomical landmark positions is presented. In this study, 5 landmark positions in each vertebra were utilized as a prior information. Based on them, a vertebral shape template was deformed in order to fit to the target vertebra. The segmentation was performed by a graph cut method in Riemannian space whose metrics were calculated from the template. In the evaluation, the improvement of segmentation accuracy in thoracic and lumbar vertebrae was shown.
Acquisition of respiratory signal during VMAT using Portal imaging

KIDA Satoshi, HAGA Akihiro, SAOTOME Naoya, MASUTANI Yoshitaka, YAMASHITA Hideomi, NAKAGAWA Keiichi

IEICE technical report　111　(199)　71-73　2011/08/30
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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Monitoring motion of the target during treatment is important for delivering accurate radiation therapy. Recently, CT reconstruction from portal images acquired during volumetric modulated arc therapy (VMAT) treatment, labeled as "VMAT-CT" has been investigated. In this study, we have developed in-house method for acquiring respiratory signal toward four dimensional (4D) version of VMAT CT.
An Analytic Solution for Diffusion Kurtosis Computation in Diffusion MR Imaging

MASUTANI Yoshitaka, AOKI Shigeki

IEICE technical report　111　(127)　11-16　2011/07/05
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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Diffusion kurtosis is a parameter to quantify the non-Gaussian motion of water molecule, and is expected as a new diagnostic measure for differentiating pathological tissues from normal ones. Two major problems in computing diffusion kurtosis in diffusion MR images are ; high computational cost, and low robustness for imaging noise. In this study, we develop an analytical method for the diffusion kurtosis computation based on simple calculus, and then regularize each diffusion weighted images in order to improve the computation robustness. Finally, some clinical experiments are also performed to prove the effectiveness and of our methods.
拡散MRIの臨床応用

青木茂樹, 堀正明, 増谷佳孝, 阿部修, 鎌形康司, 服部高明

日本神経学会学術大会プログラム・抄録集　52nd　2011
Q-ball imaging tractographyとfMRIを併用した錐体路分離描出

鈴木雄一, 増谷佳孝, 伊藤賢司, 井野賢司, 後藤政実, 矢野敬一, 大友邦

日本放射線技術学会東京部会雑誌　(120)　2011

ISSN： 0916-9652
Jump-Diffusionに基づく組み合わせ最適化によるHARDIにおけるMPG削減

岩本和成, 澤田好秀, 本谷秀堅, 増谷佳孝

日本医用画像工学会大会予稿集(CD-ROM)　30th　2011

ISSN： 0288-450X
画像診断の集合知的側面と臨床CAD環境

増谷佳孝

日本医学放射線学会総会抄録集　70th　2011

ISSN： 0048-0428
Improvement of automated detection for anatomical landmarks within medical images-Increasing detection performance for soft tissue related landmarks-

根本充貴, 増谷佳孝, 増谷佳孝, 花岡昇平, 野村行弘, 吉川健啓, 林直人, 吉岡直紀, 大友邦, 大友邦

電子情報通信学会技術研究報告　111　(47(IE2011 9-39))　2011

ISSN： 0913-5685
Report on MICCAI 2010

SHIMIZU Akinobu, KITASAKA Takayuki, MASUTANI Yoshitaka, NAKANO Yuta, ODA Masahiro, HONTANI Hidekata, NEMOTO Mitsutaka, MORI Kensaku

IEICE technical report　110　(280)　77-82　2010/11/08
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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This paper focuses on about 70 % of sessions in workshops and a main conference of MICCAI2010, and introduces the outline and a few interesting papers of each session.
A landmark set optimization algorithm from large lists of detected candidates of multiple landmarks <2nd report>-Set optimization of candidates detected from images with various examination range-

根本充貴, 花岡昇平, 増谷佳孝, 増谷佳孝, 野村行弘, 吉川健啓, 林直人, 吉岡直紀, 大友邦, 大友邦

電子情報通信学会技術研究報告　110　(280)　23-26　2010/11/08
Publisher: 社団法人電子情報通信学会
ISSN： 0913-5685
Web-based CAD server for clinical use, evaluation, and incremental learning : Preliminary study for incremental learning of CAD software based on clinical feedback

NOMURA Yukihiro, HAYASHI Naoto, MASUTANI Yoshitaka, YOSHIKAWA Takeharu, NEMOTO Mitsutaka, HANAOKA Shouhei, MIKI Soichiro, MAEDA Eriko, OHTOMO Kuni

IEICE technical report　110　(195)　31-36　2010/08/27
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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We have been building a web-based CAD server that enables radiologists to use CAD software and to give feedback in clinical environment. The platform has been utilized in our hospital for 20 months, and more than 2,500 cases of feedback data have been accumulated. In this short report, we investigated an incremental learning of CAD software based on clinical feedback by using CAD applications for detecting cerebral aneurysms in MR angiograms.
Study on anatomical landmark detection from CT image via three-dimensional SIFT

根本充貴, 野村行弘, 増谷佳孝, 増谷佳孝, 花岡昇平, 吉川健啓, 林直人, 吉岡直紀, 大友邦, 大友邦

電子情報通信学会技術研究報告　110　(195)　49-54　2010/08/27
Publisher: 社団法人電子情報通信学会
ISSN： 0913-5685
A landmark set optimization algorithm from large lists of detected candidates of muitiple landmarks

花岡昇平, 増谷佳孝, 増谷佳孝, 野村行弘, 根本充貴, 前田恵理子, 吉川健啓, 林直人, 吉岡直紀, 大友邦, 大友邦

電子情報通信学会技術研究報告　110　(195)　67-74　2010/08/27
Publisher: 社団法人電子情報通信学会
ISSN： 0913-5685
Tract-specific analysis for investigation of Alzheimer disease: a brief review

Yasuhiro Nakata, Shigeki Aoki, Noriko Sato, Hasina Yasmin, Yoshitaka Masutani, Kuni Ohtomo

JAPANESE JOURNAL OF RADIOLOGY　28　(7)　494-501　2010/08

DOI： 10.1007/s11604-010-0460-y 　

ISSN： 1867-108X
インビボ蛍光イメージングを用いたマウスリンパ流路の解析

井上優介, 桐生茂, 増谷佳孝, 渡辺慎, 拝師智之, 吉川宏起, 嶋田守男, 小柳津直樹, 大友邦

JSMI Report　3　(2)　153-153　2010/05
Publisher: 日本分子イメージング学会
ISSN： 1882-6490
グリオーマ手術におけるFunctional neuronavigationの有用性とその効果の実際

鎌田恭輔, 太田貴裕, 國井尚人, 青木茂樹, 増谷佳孝, 川合謙介, 斉藤延人

脳神経外科ジャーナル　19　(Supplement)　54　2010/04/20

ISSN： 0917-950X
The Project "Computational Anatomy", funded by MEXT Grant-in-Aid for Scientific Research on Innovative Areas : What is aimed at? What is expected?

KOBATAKE Hidefumi, MASUTANI Yoshitaka, SATO Yoshinobu, FUJITA Hiroshi, NIKI Noboru, MORI Kensaku, SHIMIZU Akinobu, KIDO Shoji, HASHIZUME Makoto, HANEISHI Hideaki, HASEGAWA Jun-ichi, SATO Tetsuo

IEICE technical report　109　(407)　205-210　2010/01/21
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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A five-year project entitled "Computational anatomy for computer-aided diagnosis and therapy: Frontiers of medical image sciences" has started in July, 2009, which is funded by MEXT Grant-in-Aid for Scientific Research on Innovative Areas. In this panel discussion, the panelists, including the investigators of the project and observers, will discuss what is aimed at and what is expected.
The effect of training with simple pointed lesion dataset on classification accuracy-Preliminary study for development of CAD software with incremental learning function on clinical application-

根本充貴, 野村行弘, 増谷佳孝, 増谷佳孝, 花岡昇平, 吉川健啓, 林直人, 吉岡直紀, 大友邦, 大友邦

電子情報通信学会技術研究報告　109　(407)　247-252　2010/01/21
Publisher: 社団法人電子情報通信学会
ISSN： 0913-5685
An experimental method for MPG decimation in HARDI

MASUTANI Yoshitaka, SUZUKI Yuichi, ITOH Kenji, ABE Osamu, AOKI Shigeki, OHTOMO Kuni

IEICE technical report　109　(407)　317-320　2010/01/21
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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In diffusion MR imaging, including High Angular Resolution Diffusion Imaging(HARDI), directions of motion probing gradient(MPG)are assigned in an isotropic distribution so that every tract structure is equally managed. However, if imaging target is limited, we can optimize MPG assignment in anisotropic manner, and consequently shorten imaging time by reducing total number of MPG directions without damaging diffusion profile depicting crossing fibers. In this abstract, we describe our practical method for anisotropic MPG reduction. By using clinical data of healthy volunteers, MPG assignment is optimized for specific tract structure, and feasibility of MPG decimation is shown.
MRIにおける信号値不均一・歪み補正の大脳皮質厚への影響:FreeSurferを用いた検討

阿部修, 高尾英正, 椛沢宏之, 後藤政美, 五ノ井渉, 佐々木弘喜, 森墾, 國松聡, 増谷佳孝, 大友邦

日本医学放射線学会総会抄録集　69th　2010

ISSN： 0048-0428
Report of MICCAI2009 : Investigation of research trends

SATO Yoshinobu, MASUTANI Yoshitaka, MORI Kensaku, HAYASHI Tatsuro, OTOMARU Itaru, YOKOTA Futoshi, KITASAKA Takayuki

IEICE technical report　109　(270)　47-54　2009/10
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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The MICCAI conference is one of the most prestigious conferences in the research field of medical image processing. In this paper, MICCAI2009, which was held in London from September 20 to 24, 2009, is reported. In addition to noteworthy papers presented at the main conference and satellite workshops, the purpose, philosophy, and future directions of the MICCAI conference are described.
拡散MRIに基づく確率的Tractographyにおける描出パラメータの局所調整による改善の一手法

伊藤賢司, 増谷佳孝, 青木茂樹, 阿部修, 大友邦

MEDICAL IMAGING TECHNOLOGY　27　(Suppl.)　1-8　2009/08
Publisher: 日本医用画像工学会
ISSN： 0288-450X
Building a web-based CAD process server for clinical use of CAD software

NOMURA Yukihiro, HAYASHI Naoto, MASUTANI Yoshitaka, YOSHIKAWA Takeharu, NEMOTO Mitsutaka, HANAOKA Shouhei, MAEDA Eriko, OHTOMO Kuni

IEICE technical report　109　(127)　13-18　2009/07/08
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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The development of computer-assisted detection (CAD) software involves a cycle such as algorithm development, software implementation, clinical use, refinement of the algorithm and the software based on feedback by clinical use, and further clinical use. The cycle accelerates development of CAD software. In this short report, we describe our web-based CAD process server and our first experience of its clinical application.
一般化円筒モデルに基づく脊椎椎体の海綿骨、皮質骨の分離と標準化骨濃度マップの作成(画像解析)

花岡昇平, 野村行弘, 根本充貴, 増谷佳孝, 前田恵理子, 吉川健啓, 林直人, 吉岡直紀, 大友邦

電子情報通信学会技術研究報告. MI, 医用画像　109　(127)　33-38　2009/07/08
Publisher: 社団法人電子情報通信学会
ISSN： 0913-5685

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医用CT画像における脊柱椎体の海綿骨抽出を目的として、椎体断面図形の2次元可変形モデルを作成した。モデル作成にはActive shape model(ASM)を用いた。輪郭点の選び方やモデルの自由度の異なるさまざまなモデルを作成し、実際の椎体断面図形に適用して、それぞれ評価を行った。評価の指標としてはoverlap index、ならびにモデルと実際の断面図形との最大距離を用いた。さらに作成したモデルを断面とする3次元の一般化円筒モデルを作成し、これにより個々の椎体の海綿骨のセグメンテーションが可能であることを確認した。
Study of learning for classifier ensemble to differentiate lesion voxels-Relation between initial weight for training sample data and classification accuracy of trained ensemble-

根本充貴, 野村行弘, 増谷佳孝, 増谷佳孝, 花岡昇平, 吉川健啓, 林直人, 吉岡直紀, 大友邦, 大友邦

電子情報通信学会技術研究報告　109　(127)　75-78　2009/07/08
Publisher: 社団法人電子情報通信学会
ISSN： 0913-5685
3テスラMRIにおける信号値不均一・歪み補正の脳実質容積への影響

阿部修, 高尾英正, 椛沢宏之, 後藤政美, 五ノ井渉, 佐々木弘喜, 森墾, 國松聡, 増谷佳孝, 大友邦

日本医学放射線学会総会抄録集　68th　2009

ISSN： 0048-0428
fMRIとDTTによるfrontotemporal language fibersの視覚化

井野賢司, 鈴木雄一, 後藤政実, 佐竹芳朗, 鎌田恭輔, 増谷佳孝, 美馬和男

日本放射線技術学会総会学術大会予稿集　65th　2009

ISSN： 1884-7846
脳神経領域における診断と治療の融合的支援システムの開発

増谷佳孝, 伊藤大輔, 鎌田恭輔, 青木茂樹, 青木茂樹, 阿部修, 大友邦

日本医用画像工学会大会予稿集(CD-ROM)　28th　2009

ISSN： 0288-450X
Three-dimensional corticospinal tractography 皮質脊髄路の拡散テンソルtractography-総論

青木茂樹, 増谷佳孝

月刊神経内科　70　(3)　2009

ISSN： 0386-9709
皮質-白質言語機能マッピング併用覚醒下手術による脳腫瘍摘出術

鎌田恭輔, 太田貴裕, 國井尚人, 増谷佳孝, 青木茂樹, 斉藤延人

日本Awake Surgery研究会プログラム・抄録集　7th　2009
拡散テンソルtractography

青木茂樹, 増谷佳孝, 阿部修

日本神経放射線学会プログラム・抄録集　38th　2009
Tractographyと白質刺激によるeloquent白質境界領域の同定

鎌田恭輔, 太田貴裕, 國井尚人, 青木茂樹, 増谷佳孝, 川合謙介, 斉藤延人

日本脳腫瘍の外科学会プログラム・抄録集　14th　2009
Neural correlates of long-term associative memory in human temporal cortex

Seiki Konishi, Ken-ichiro Yamashita, Satoshi Hirose, Akira Kunimatsu, Shigeki Aoki, Junichi Chikazoe, Koji Jimura, Yoshitaka Masutani, Osamu Abe, Kuni Ohtomo, Yasushi Miyashita

NEUROSCIENCE RESEARCH　65　S236-S236　2009

DOI： 10.1016/j.neures.2009.09.1331 　

ISSN： 0168-0102
Visualizing Anisotropic Structures in Brain Based on Diffusion Tensor Tractography

MASUTANI Yoshitaka

IEEJ Transactions on Sensors and Micromachines　128　(1)　20-22　2008/10/10
Publisher: The Institute of Electrical Engineers of Japan
DOI： 10.1541/ieejjournal.128.20 　

ISSN： 1340-5551 1881-4190

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This article has no abstract.
Radiosurgeryへの錐体路/視放線/弓状束tractography統合による合併症予防の達成

丸山啓介, 甲賀智之, 鎌田恭輔, 太田貴裕, 伊藤大輔, 井野賢司, 青木茂樹, 井垣浩, 増谷佳孝, 辛正廣, 斉藤延人

日本脳神経外科学会総会CD-ROM抄録集　67回　2J-02　2008/10
Publisher: (一社)日本脳神経外科学会
ISSN： 1347-9040
Diffusion tensor imaging of the brain: Effects of distortion correction with correspondence to numbers of encoding directions

Takeharu Yoshikawa, Shigeki Aoki, Osamu Abe, Naoto Hayashi, Yoshitaka Masutani, Tomohiko Masumoto, Harushi Mori, Yoshiroh Satake, Kuni Ohtomo

Radiation Medicine - Medical Imaging and Radiation Oncology　26　(8)　481-487　2008/10/01

DOI： 10.1007/s11604-008-0262-7 　

ISSN： 0288-2043
WS2-1 日本のTractography最新情報 : Tractographyと電気生理モニタリング融合によるeloquent networkの画像化(てんかんの最先端医療,ワークショップ2,第42回日本てんかん学会)

鎌田恭輔, 川合謙介, 太田貴裕, 増谷佳孝, 青木茂樹, 斉藤延人

てんかん研究　26　(2)　254-254　2008/09/30
Publisher: 日本てんかん学会
ISSN： 0912-0890
216 3T MRIにおけるPropeller法を用いた脳幹神経路DTIの改善(MR検査脳-計測,第36回日本放射線技術学会秋季学術大会)

井野賢司, 増谷佳孝, 椛沢宏之, 後藤政実, 佐竹芳朗, 飯田恭人, 青木茂樹, 美馬和男

日本放射線技術學會雜誌　64　(9)　1121-1121　2008/09/20
Publisher: 社団法人日本放射線技術学会
ISSN： 0369-4305
Silent white matter lesion in linear scleroderma en coup de sabre

Mio Sakai, Shigeki Aoki, Yusuke Inoue, Ryuichi Ashida, Haruyasu Yamada, Shigeru Kiryu, Sachiko Inano, Harushi Mori, Yoshitaka Masutani, Osamu Abe, Kuni Ohtomo, Hironobu Nakamura

Journal of Computer Assisted Tomography　32　822-824　2008/09/01

DOI： 10.1097/RCT.0b013e318153fd60 　

ISSN： 0363-8715
【3T MRIの臨床頭部の使えるシークエンス】頭部3T MRIにおけるボリュームデータ T1強調像、拡散強調像

青木茂樹, 伊藤賢司, 増谷佳孝, 渡辺靖志, 井野賢司, 後藤政実, 阿部修, 林直人

画像診断　28　(10)　1024-1031　2008/08
Publisher: (株)学研メディカル秀潤社
ISSN： 0285-0524
Diffusion tensor imaging

Japanese journal of molecular psychiatry　8　(3)　257-259　2008/07
Publisher: 先端医学社
ISSN： 1345-9082
Survey on Visualization and Analysis Techniques Based on Diffusion MRI for in-vivo Anisotropic Diffusion Structures

MASUTANI Yoshitaka, SATO Tetsuo, URAYAMA Shin-ichi, LE BIHAN Denis

The IEICE transactions on information and systems　91　(7)　1744-1756　2008/07/01
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 1880-4535
2等賞中枢神経系MRIにおける拡散テンソル解析の基礎と臨床応用:解析ソフトウエアの開発から臨床応用までのトランスレーショナルリサーチ (ベルツ賞 2007年度受賞論文抄録紹介)

青木茂樹, 増谷佳孝, 阿部修

日本医師会雑誌　136　(12)　2475-2478　2008/03
Publisher: 日本医師会
ISSN： 0021-4493
Baelz Prize: Diffusion tensor imaging of central nervous system: development of analysis software and clinical application

63　(2)　306-349　2008/02
Publisher: 最新医学社
ISSN： 0370-8241
Development of automatic skin lesion detection for body trunk FDG-PET/CT images

NEMOTO Mitsutaka, NOMURA Yukihiro, MASUTANI Yoshitaka, HANAOKA Shohei, YOSHIKAWA Takeharu, HAYASHI Naoto, YOSHIOKA Naoki, OHTOMO Kuni

IEICE technical report　108　(271)　43-46　2008/02
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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In this paper, we propose SUV features for the skin lesion detection of body-trunk FDG-PET/CT images. Our previous detection method was based on the maximum likelihood estimation method for each skin voxels. Lesion likelihood value and normal skin likelihood value were calculated at each voxels and extracted from some features which were correlated to the local intensity pattern of CT or FDG-PET image. In this study, we propose the SUV features calculated from FDG-PET image with the consideration for the standard skin SUV distribution as the features for calculating likelihoods. We report on the results of skin lesion detection experiments with proposed features.
Segmentation algorithm for the whole vertebrae applicable to the posterior segment

花岡昇平, 野村行弘, 根本充貴, 増谷佳孝, 増谷佳孝, 前田恵理子, 吉川健啓, 林直人, 吉岡直紀, 大友邦, 大友邦

電子情報通信学会技術研究報告　108　(271)　21-26　2008/02
Publisher: 社団法人電子情報通信学会
ISSN： 0913-5685
Preliminary study of computerized detection of ground-glass opacity nodules in chest CT images

NOMURA Yukihiro, NEMOTO Mitsutaka, MASUTANI Yoshitaka, ITO Haruhiko, HANAOKA Shouhei, MAEDA Eriko, YOSHIKAWA Takeharu, HAYASHI Naoto, YOSHIOKA Naoki, OHTOMO Kuni

IEICE technical report　108　(271)　17-20　2008/02
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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We have been developing a computerized detection method of lung nodules based on volumetric curvature, and our method employs surface feature-based false positive reduction based on Mahalanobis distance. In the preliminary study, it was revealed that some of ground-glass opacity (GGO) nodules with low-contrast resulted in false negative due to the binarization for detecting nodules and vessels. In this study, we investigated a local adaptive thresholding for detecting GGO nodules with low contrast.
Processing, Visualizing and Analyzing Diffusion MR Images : From Basics to Applications

MASUTANI Yoshitaka

IEICE technical report　107　(461)　431-434　2008/01/25
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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Diffusion magnetic resonance image (MRI) is based on quantitative measurement of water diffusion, and also describes diffusion anisotropy by means of multi-directional image acquisition. Recently, diffusion MRI is clinically widespread as a source modality for visualization and quantitative analysis of brain white matter fiber bundles. In addition to significance in clinical research and medical science, researchers in related fields such as biomedical engineering and applied mathematics are attracted by diffusion MRI because of its characteristics different to scalar images. In this tutorial, basics and practical aspects in clinical use of diffusion MRI are presented with recent research outputs.
Fundamental Studies for Shape Irregularity Quantification of Cerebral Aneurysm : Experimental Study for Image Resolution Dependency of Shape Features

MASUTANI Yoshitaka, WATANABE Yu-ichi, MASUMOTO Tomohiko, AOKI Shigeki, KAMADA Kyosuke, MORITA Akio, OHTOMO Kuni

IEICE technical report　107　(461)　143-146　2008/01/25
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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We have been studying on computerized detection and shape analysis of cerebral aneurysms, aiming at translational support for diagnosis and therapy in neurosurgical area. In this report, we show experimental results on vessel-aneurysm shape separation arid the dependency on image resolution of aneurysm shape irregularity features, which are important in assessing rupture risk and difficulty assessment in embolization.
Unified Approach for Enhanced Visualization for Temporal Change and Inter-Subject Variation in Signal Intensity and Morphology in Medical Images : Fundamental Studies on Methodology without Statistical Prior

MASUTANI Yoshitaka

IEICE technical report　107　(461)　139-142　2008/01/25
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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In this study, a new visualization technique for enhancement of temporal changes or individual difference from identical modality of medical images. The proposed method includes non-rigid image registration, and is aimed at visual augmentation of local deformation and local signal change based on various statistics including prior information. In this short report, experiments on a simple methodology is described and is discussed, which based on only extrapolation of image data series without prior information.
Thin slice DTIを用いた内耳神経,顔面神経におけるtractographyの描出能改善

井野賢司, 佐竹芳朗, 飯田恭人, 美馬和男, 青木茂樹, 増谷佳孝, 鎌田恭輔

日本放射線技術学会総会学術大会予稿集　64th　2008

ISSN： 1884-7846
三叉神経Diffusion tensor tractographyとMRA,FESTAの統合

井野賢司, 佐竹芳朗, 飯田恭人, 美馬和男, 青木茂樹, 増谷佳孝, 鎌田恭輔

日本放射線技術学会総会学術大会予稿集　64th　2008

ISSN： 1884-7846
3TMRIによる三次元heavy-T2強調/MR angiography融合画像を用いた脳神経/血管構造の画像化

鎌田恭輔, 金太一, 青木茂樹, 増谷佳孝, 黒田嘉宏, 大城理, 斉藤延人

日本生体医工学会大会プログラム・論文集(CD-ROM)　47th　2008
孤発性ALS古典型画像検査

青木茂樹, 阿部修, 増谷佳孝, 岩田信恵

Clinical Neuroscience　26　(3)　2008

ISSN： 0289-0585
X線CT像における高精度気管支領域抽出のためのCT値/MDS分布の計測と解析

渡邉雄一, 増谷佳孝, 林直人, 吉川宏起, 佐藤昌憲, 美馬和男, 大友邦

日本放射線技術学会総会学術大会予稿集　64th　2008

ISSN： 1884-7846
生理的加齢における脳内拡散能変化の男女差

阿部修, 山末英典, 山田晴耕, 青木茂樹, 笠井清登, 井上秀之, 武井邦夫, 菅心, 増谷佳孝, 大友邦

日本医学放射線学会総会抄録集　67th　2008

ISSN： 0048-0428
Voxel-based Analyses of Gray/White Matter Volume and Diffusion Tensor Data in Major Depression

阿部修, 山末英典, 山田晴耕, 青木茂樹, 笠井清登, 井上秀之, 武井郁夫, 菅心, 増谷佳孝, 大友邦

日本磁気共鳴医学会雑誌　28　(1)　2008

ISSN： 0914-9457
成人発症vanishing white matter disease

森墾, 青木茂樹, 松川敬志, 國島加奈子, 佐藤次郎, 加藤伸之, 阿部修, 増本智彦, 伊藤大輔, 増谷佳孝, 辻省次, 大友邦

日本神経放射線学会プログラム・抄録集　37th　2008
Curvature-Based Automated Detection of Pulmonary Nodules in CT Images with Surface Feature-Based False Positive Reduction

NOMURA Yukihiro, ITOH Haruhiko, MAEDA Eriko, MASUTANI Yoshitaka, YOSHIKAWA Takeharu, HAYASHI Naoto, OHTOMO Kuni

Medical Imaging Technology　25　(5)　381-388　2007/12
Publisher: The Japanese Society of Medical Imaging Technology
DOI： 10.11409/mit.25.381 　

ISSN： 0288-450X
SIMD-based computation of similarity measure and geometric transformation for fast image registration

増谷佳孝, 桐生茂, 花岡昇平, 野村行弘, 根本充貴, 林直人, 青木茂樹, 大友邦

電子情報通信学会技術研究報告　107　(326(MI2007 48-62))　7-12　2007/11/09
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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Image registration is one of the key technologies in medical imaging, and requires high computational cost. We implemented similarity measure computation and geometric deformation as principle elements in image registration, by using SIMD technology, and investigated the acceleration effect.
画像レジストレーションの高速化を目的としたSIMDによる類似度計算

増谷佳孝, 桐生茂, 花岡昇平, 野村行弘, 根本充貴, 林直人, 青木茂樹, 大友邦

コンピュータ支援画像診断学会大会・日本コンピュータ外科学会大会合同論文集　17th-16th　269-270　2007/11/02
Eloquent fiber tractographyとマルチ電気生理学モニタリングによる白質マッピングの検証と課題

鎌田恭輔, 川合謙介, 藤堂具紀, 太田貴裕, 増谷佳孝, 青木茂樹, 斉藤延人

日本脳神経外科学会総会CD-ROM抄録集　66回　1D-S04　2007/10
Publisher: (一社)日本脳神経外科学会
ISSN： 1347-9040
術中Diffusion Tensor Tractographyが可能なニューロナビゲーション装置の開発とその臨床応用

金太一, 鎌田恭輔, 太田貴裕, 増谷佳孝, 青木茂樹, 川合謙介, 藤堂具紀, 斉藤延人

日本脳神経外科学会総会CD-ROM抄録集　66回　2J-O27　2007/10
Publisher: (一社)日本脳神経外科学会
ISSN： 1347-9040
Measurement and Analysis of Morphologically Determined Size and Signal Intensity Distributions for High-Precision Segmentation of Bronchi in X-ray CT Images

WATANABE Yuichi, MASUTANI Yoshitaka, NOMURA Yukihiro, YOSHIKAWA Takeharu, HAYASHI Naoto, YOSHIKAWA Kouki, SATOH Masanori, OHTOMO Kuni

Medical Imaging Technology　25　(4)　219-226　2007/09/25
Publisher: The Japanese Society of Medical Imaging Technology
DOI： 10.11409/mit.25.219 　

ISSN： 0288-450X
Investigation of normalization coefficient for scale matching using Hessian matrix

NOMURA Yukihiro, MASUTANI Yoshitaka, HAYASHI Naoto, YOSHIKAWA Takeharu, OHTOMO Kuni

IEICE technical report　107　(133)　1-6　2007/07/04
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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Scale matching based on Hessian matrix is utilized standard deviation of a Gauss function to a coefficient power as a normalization. However, the optimal normalized factor depends on edge shape of the structutre, and so on. In this study, we investigated a relation between edge shape of the structutre and optimal normalized factor by numerical analysis, syntheric data and chest CT images. Moreover, we investigated a decision of the normalized factor in the case of unknown shape information of the structutre.
Functional identification of the primary motor area by corticospinal tractography (Reprinted from Neurosurgery, vol 56, pg 98-109, 2005)

Kyousuke Kamada, Yutaka Sawamura, Fumiya Takeuchi, Hideaki Kawaguchi, Shinya Kuriki, Tomoki Todo, Akio Morita, Yoshitaka Masutani, Shigeki Aoki, Takaaki Kirino

NEUROSURGERY　61　(1)　166-176　2007/07

ISSN： 0148-396X

eISSN： 1524-4040
【脳腫瘍の診断と治療グリオーマにおける画像診断の役割を中心に】 Fiber trackingの脳腫瘍手術ナビゲーションへの応用

鎌田恭輔, 青木茂樹, 増谷佳孝, 井野賢二, 藤堂具紀, 川合謙介, 太田貴裕, 斉藤延人

臨床放射線　52　(6)　759-765　2007/06
Publisher: 金原出版(株)
ISSN： 0009-9252
基礎・総論編画像診断の最新技術と応用拡散テンソル画像とはどのようなものですか。臨床的にどのように応用できますか。

大場洋, 青木茂樹, 阿部修, 増谷佳孝

小児内科　39　2007

ISSN： 0385-6305
上縦束の事前抽出に基づくDTT手法を用いた脳梗塞患者における錐体路描出

伊藤大輔, 青木茂樹, 増谷佳孝, 阿部修, 増本智彦, 森墾, 大友邦

日本医学放射線学会学術集会抄録集　66th　2007

ISSN： 0048-0428
脳腫瘍の診断と治療:グリオーマにおける画像診断の役割を中心に Fiber trackingと電気生理モニタリング融合型脳腫瘍手術ナビゲーション

鎌田恭輔, 青木茂樹, 増谷佳孝, 井野賢二, 藤堂具紀, 川合謙介, 太田貴裕, 斉藤延人

日本神経放射線学会プログラム・抄録集　36th　2007
Diffusion tensor tractographyにおける描出能評価を目的とした模擬ファントムの開発

井野賢司, 鈴木雄一, 佐竹芳郎, 美馬和男, 渡辺慎, 増谷佳孝, 青木茂樹

日本放射線技術学会総会学術大会予稿集　63rd　2007

ISSN： 1884-7846
Mild cognitive impairment(MCI:軽度認知障害)3T MRIによる認知症およびその類似疾患の診断

青木茂樹, 阿部修, 増谷佳孝, 後藤政実, 林直人

月刊神経内科　67　(6)　2007

ISSN： 0386-9709
PROPELLER法を用いた3T拡散テンソルトラクトグラフィーの基礎検討

椛沢宏之, 青木茂樹, 増谷佳孝, 阿部修, 増本智彦, 林直人, 大友邦

日本医学放射線学会学術集会抄録集　66th　2007

ISSN： 0048-0428
生理的加齢における脳内拡散能変化の男女差

阿部修, 山未英典, 青木茂樹, 菅心, 山田晴耕, 笠井清登, 増谷佳孝, 井上秀之, 佐竹芳朗, 大友邦

日本医学放射線学会学術集会抄録集　66th　2007

ISSN： 0048-0428
視放線Diffusion tensor tractographyのガンマナイフ治療への統合

井野賢司, 佐竹芳郎, 美馬和男, 丸山啓介, 鎌田恭輔, 増谷佳孝, 青木茂樹

日本放射線技術学会総会学術大会予稿集　63rd　2007

ISSN： 1884-7846
Step up MRI 2007 II ここまで見える3T MRI-解剖を超えて 1.3T MRIによる脳の解剖

青木茂樹, 阿部修, 増谷佳孝, 椛沢宏之, 渡辺靖志, 佐竹芳郎, 後藤政実, 美馬和男, 大友邦, 大友邦

Innervision　22　(9)　2007

ISSN： 0913-8919
DTTにおける描出能評価を目的とした模擬ファントムによるNEXとMPGの検討

鈴木雄一, 井野賢司, 佐竹芳朗, 飯田恭人, 美馬和男, 増谷佳孝, 大友邦

日本放射線技術学会総会学術大会予稿集　63rd　2007

ISSN： 1884-7846
Alzheimer病における後部帯状束の拡散テンソル指標と海馬の体積-重症度との相関についての検討

中田安浩, 佐藤典子, 根本清貴, 青木茂樹, 阿部修, 鹿倉頌子, 有馬邦正, 増谷佳孝, 大友邦

日本医学放射線学会学術集会抄録集　66th　2007

ISSN： 0048-0428
MRIで脳の機能を探る:臨床応用を中心に

青木茂樹, 阿部修, 増谷佳孝, 鎌田恭輔, 大友邦

日本医学会総会総会会誌　27th　2007
3T MRIの臨床中枢神経

青木茂樹, 阿部修, 増谷佳孝, 椛沢宏之, 後藤政実, 林直人

臨床画像　23　(11)　2007

ISSN： 0911-1069
技術交流の輪-3 非剛体レジストレーションの基礎

増谷佳孝, 増谷佳孝

CADM News Letter　(51)　2007

ISSN： 1341-9447
拡散テンソル画像による錐体路および視放線tractographyのガンマナイフへの統合

丸山啓介, 甲賀智之, 鎌田恭輔, 太田貴裕, 伊藤大輔, 井野賢司, 青木茂樹, 多湖正夫, 増谷佳孝, 辛正廣, 斉藤延人

日本脳神経外科学会総会抄録集(CD-ROM)　66th　2007

ISSN： 1347-9040
全身PET/CT像を用いたCADシステム構築における初期的検討

根本充貴, 増谷佳孝, 野村行弘, 吉川健啓, 林直人, 大友邦

コンピュータ支援画像診断学会大会・日本コンピュータ外科学会大会合同論文集　17th-16th　2007
胸部CT画像からの肺結節自動検出における表面情報を用いた偽陽性削減処理の改良

野村行弘, 根本充貴, 増谷佳孝, 増谷佳孝, 伊藤治彦, 前田恵理子, 吉川健啓, 林直人, 大友邦, 大友邦

コンピュータ支援画像診断学会大会・日本コンピュータ外科学会大会合同論文集　17th-16th　2007
楕円柱モデルを用いた体幹部CT画像の脊椎-脊柱管検出アルゴリズム

花岡昇平, 野村行弘, 根本充貴, 増谷佳孝, 増谷佳孝, 前田恵理子, 吉川健啓, 林直人, 吉岡直紀, 大友邦, 大友邦

コンピュータ支援画像診断学会大会・日本コンピュータ外科学会大会合同論文集　17th-16th　2007
Diffusion tentor tractography

青木茂樹, 増谷佳孝, 阿部修

神経研究の進歩　50　(6)　964-970　2006/12
Publisher: 医学書院
ISSN： 0001-8724
拡散テンソルトラクトグラフィによる脊髄小脳変性症の錐体路評価

岩田信恵, 青木茂樹, 後藤順, 増谷佳孝, 辻省次, 宇川義一

臨床神経学　46　(12)　1084-1084　2006/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X
フリーハンド3次元超音波の複数回走査における画像合成の一方法

野村行弘, 吉川健啓, 林直人, 増谷佳孝, 宇野漢成, 前田恵理子, 大友邦, 荒井修, 三竹毅

日本コンピュータ外科学会誌　8　(3)　202-203　2006/12
Publisher: (一社)日本コンピュータ外科学会
ISSN： 1344-9486

eISSN： 1884-5770
293 Tractographyのガンマナイフ治療への応用(MR検査フュージョン画像,一般研究発表,日本放射線技術学会第34回秋季学術大会)

井野賢司, 佐竹芳朗, 美馬和男, 丸山啓介, 鎌田恭輔, 増谷佳孝, 青木茂樹

日本放射線技術學會雜誌　62　(9)　1261-1261　2006/09/20
Publisher: 社団法人日本放射線技術学会
ISSN： 0369-4305
Corticospinal tracts by diffusion tensor tractography in patients with arteriovenous malformations

Daisuke Itoh, Shigeki Aoki, Keisuke Maruyama, Yoshitaka Masutani, Harushi Mori, Tomohiko Masumoto, Osamu Abe, Naoto Hayashi, Toshiyuki Okubo, Kuni Ohtomo

Journal of Computer Assisted Tomography　30　618-623　2006/07/01

DOI： 10.1097/00004728-200607000-00011 　

ISSN： 0363-8715
IEEE ISBI 2006

MASUTANI Yoshitaka

24　(3)　216-217　2006/05/25

ISSN： 0288-450X
Construction of Statistical Atlas for Brain White Matter Fiber Tract Embedding Diffusion Tensor Parameters and its Augmentation to HARD-MRI

MASUTANI Yoshitaka, AOKI Shigeki, ABE Osamu, OHTOMO Kuni

IEICE technical report　105　(580)　61-64　2006/01/21
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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The diffusion tensor tractography has limitations based on low objectivity by interactive ROI setting and fiber-crossing. For addressing such problems, we have been constructing a statistical atlas of white matter fiber tracts, in which probability density maps of tract structures are stored with diffusion tensor parameters on spatially normalized brain data. We augment the atlas with information of diffusion profiles of higher angular resolution obtained by HARD-MRI. In this abstract, we describe our statistical atlas, and the preliminary results.
Inter-Region Connectivity Assessment by using Level-Set Method based on DT-MRI and HARD-MRI

MASUTANI Yoshitaka, AOKI Shigeki, ABE Osamu, OHTOMO Kuni

IEICE technical report　105　(579)　21-24　2006/01/20
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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Several groups have reported studies on white matter connectivity based on information obtained from diffusion MRI. Among them, approaches based on level-set method are similar to diffusion simulation and are expected to be applied in clinical environment. We have been developing our original speed functions both for DT-MRI and HARD-MRI. In this abstract, we present comparison results of various speed functions with clinical data sets including normal and infarction cases.
MRIによる多方向拡散強調イメージングのための後処理およびその臨床応用について

増谷佳孝, 青木茂樹, 阿部修, 森墾, 渡谷岳行, 増本智彦, 大友邦

日本生体医工学会大会プログラム・論文集　45th　2006

ISSN： 1347-443X
脳血管障害総論 IX.画像機器・診断の進歩各論 MRI 拡散テンソルtractography

青木茂樹, 阿部修, 増谷佳孝, 椛沢宏之, 國松聡

日本臨床　64　2006

ISSN： 0047-1852
確率分布マップを用いたラクナ梗塞の症状推定の有用性についての検討

伊藤大輔, 青木茂樹, 増谷佳孝, 大久保敏之, 井上優介, 阿部修

日本医学放射線学会学術集会抄録集　65th　2006

ISSN： 0048-0428
拡散テンソルに基づくMRIの進歩拡散テンソルトラクトグラフィーについて

増谷佳孝, 増谷佳孝

月刊神経内科　65　(2)　2006

ISSN： 0386-9709
拡散テンソルtractographyを用いた錐体路各成分の白質マップ小梗塞における検討

青木茂樹, 伊藤大輔, 阿部修, 増谷佳孝, 岩田信恵, 野尻龍二, 橋本和大, 難波清隆

断層映像研究会雑誌　33　(1)　2006

ISSN： 0914-8663
皮質-白質機能neuronavigationと電気生理モニタリング融合によるeloquent brain functionの温存手術

鎌田恭輔, 藤堂具紀, 川合謙介, 太田貴裕, 川原信隆, 増谷佳孝, 青木茂樹, 斉藤延人

日本脳神経外科学会総会抄録集(CD-ROM)　65th　2006

ISSN： 1347-9040
生理的加齢性変化に鋭敏な指標は容積,拡散異方性,平均拡散能?

阿部修, 山末英典, 青木茂樹, 菅心, 山田晴耕, 笠井清登, 増谷佳孝, 加藤伸之, 加藤進昌, 大友邦

日本医学放射線学会学術集会抄録集　65th　2006

ISSN： 0048-0428
DT-MRIを用いた錐体路抽出における描出能向上の一手法:上縦束の事前抽出と交叉線維のテンソル推定

増谷佳孝, 青木茂樹, 阿部修, 大友邦

日本医用画像工学会大会予稿集(CD-ROM)　25th　2006

ISSN： 0288-450X
錐体路の拡散テンソルtractography描出能向上の一手法:上縦束の事前抽出と交叉線維のテンソル推定

青木茂樹, 増谷佳孝, 阿部修, 大友邦

断層映像研究会雑誌　33　(2)　2006

ISSN： 0914-8663
神経画像診断の新しい展開-CTとMR MRの応用 Diffusion tensor tractography

青木茂樹, 増谷佳孝, 阿部修

Clinical Neuroscience　24　(4)　2006

ISSN： 0289-0585
視放線tractographyのガンマナイフ治療への統合

大谷亮平, 丸山啓介, 鎌田恭輔, 増谷佳孝, 多湖正夫, 伊藤大輔, 井野賢治, 齊藤延人

日本脳神経外科学会総会抄録集(CD-ROM)　65th　2006

ISSN： 1347-9040
Building statistical atlas of white matter fiber tract based on vector/tensor field reconstruction in diffusion tensor MRI

Yoshitaka Masutani, Shigeki Aoki, Osamu Abe, Mariko Yoshida, Haruyasu Yamada, Harushi Mori, Kenji Ino, Kuni Ohtomo

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)　3804 LNCS　84-91　2005/12/01

DOI： 10.1007/11595755_11 　

ISSN： 0302-9743
Somatotopic organization of pyramidal tracts studied by diffusion tensor tractography registered by Statistical Parametric Mapping (SPM)

NK Iwata, S Aoki, Y Terao, O Abe, Y Masutani, S Tsuji, Y Ugawa

JOURNAL OF THE NEUROLOGICAL SCIENCES　238　S258-S258　2005/11

ISSN： 0022-510X
強度放射線治療(IMRT)の現状と課題 (特集2 放射線治療)

中川恵一, 増谷佳孝, 川上秀之

映像情報medical　37　(12)　1239-1243,1190　2005/11
Publisher: 産業開発機構
ISSN： 1346-1354
Quantitative Evaluation of the White Matter Tracts of the Limbic System Segmented by Diffusion Tensor Tractography with Schizophrenia : A Preliminary Study

AOKI Shigeki, YAMADA Haruyasu, ABE Osamu, YOSHIDA Mariko, YAMASUE Hidenori, KASAI Kiyoto, MASUTANI Yoshitaka, MORI Harushi, MASUMOTO Tomohiko, YOSHIKAWA Takeharu, HAYASHI Naoto, KABASAWA Hiroyuki, ITO Daisuke, INO Kenji, OHTOMO Kuni, KATO Nobumasa

日本磁気共鳴医学会雑誌　25　(1)　29-35　2005/11

ISSN： 0914-9457
MR Diffusion Tensor Analysis of Schizophrenic Brain Using Statistical Parametric Mapping

YAMADA Haruyasu, ABE Osamu, KASAI Kiyoto, YAMASUE Hidenori, AOKI Shigeki, YOSHIKAWA Takeharu, KUNIMATSU Akira, MORI Harushi, MASUMOTO Tomohiko, HAYASHI Naoto, OKUBO Toshiyuki, MASUTANI Yoshitaka, KABASAWA Hiroyuki, KATO Nobumasa, OHTOMO Kuni

25　(1)　39-41　2005/11

ISSN： 0914-9457
H-023 On Tensor Reorientation Accuracy in Non-Rigid Deformation of Diffusion Tensor MRI based on Radial Basis Functions

Masutani Yoshitaka, Watadani Takeyuki, Aoki Shigeki, Abe Osamu, Ohtomo Kuni

4　(2)　351-352　2005/08/22
Publisher: Forum on Information Technology
Recent Advances of Neuro-MR Imaging

青木茂樹, 増谷佳孝, 阿部修, 井野賢司, 森墾, 増本智彦, 吉川健啓, 渡辺慎, 渡辺靖志, 佐竹芳朗, 林直人, 大友邦, 堀正明, 石亀慶一, 熊谷博司, 荒木力

日獨医報　50　(1)　133-154　2005/04
Publisher: バイエル薬品(株)
ISSN： 0912-0351
D-16-5 Improvement of registration method for medical volume data

Tomita Naofumi, Simizu Akinobu, Kobatake Hidefumi, Masutani Yositaka

Proceedings of the IEICE General Conference　2005　(2)　307-307　2005/03/07
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 1349-1369
機能MRIを用いた言語関連脳領域の局在と皮質刺激による結果の検証

鎌田恭輔, 川合謙介, 増谷佳孝, 青木茂樹, 桐野高明

てんかん研究　23　(1)　44-45　2005/02
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890
拡散テンソル tractography の検証を目的としたファントムの作成

渡辺慎, 増谷佳孝, 青木茂樹, 森墾, 阿部修, 林直人, 増本智彦, 山田晴耕, 吉川健啓, 椛沢宏之, 大友邦

日本醫學放射線學會雜誌　65　(4)　449-451　2005/02
Publisher: 日本医学放射線学会
ISSN： 0048-0428
Quantitative Evaluation of the White Matter Tracts of the Limbic System Segmented by Diffusion Tensor Tractography with Schizophrenia: A Preliminary Study

青木茂樹, 山田晴耕, 阿部修, 吉田まり子, 山末英典, 笠井清登, 増谷佳孝, 森墾, 加藤進昌

日本磁気共鳴医学会雑誌　25　(1)　2005

ISSN： 0914-9457
錐体路tractographyのガンマナイフ治療への統合:運動合併症回避のための最新技術

丸山啓介, 鎌田恭輔, 辛正広, 青木茂樹, 増谷佳孝, 多湖正夫, 桐野高明

日本脳神経外科学会総会抄録集(CD-ROM)　64th　2005

ISSN： 1347-9040
Tractography統合型Neuronavigationと複合電気生理学モニタリングによるEloquent Fiber Mapping

鎌田恭輔, 藤堂具紀, 川合謙介, 森田明夫, 川原信隆, 増谷佳孝, 青木茂樹, 桐野高明

日本脳神経外科学会総会抄録集(CD-ROM)　64th　2005

ISSN： 1347-9040
動径基底関数を用いたベクトル場補間による拡散テンソルtractography

青木茂樹, 伊藤大輔, 増谷佳孝, 吉田茉莉子, 森墾, 阿部修, 増本智彦, 林直人, 大久保敏之, 山田晴耕, 中田安浩

日本神経放射線学会プログラム・抄録集　34th　2005
水平注視麻痺・進行側弯症における脳幹病変:臨床症状と画像の対比

森墾, 藤代貴志, 林直人, 青木茂樹, 阿部修, 増谷佳孝, 増本智彦, 山田晴耕, 吉川健啓, 渡辺慎, 大友邦

日本神経放射線学会プログラム・抄録集　34th　2005
内科医として知っておきたい画像診断法【画像診断の基礎知識と進歩】拡散テンソルtractgraphy

青木茂樹, 増谷佳孝, 阿部修

Medicina　42　(3)　2005

ISSN： 0025-7699
高次脳機能の局在とその相互連関拡散テンソルtractography

青木茂樹, 増谷佳孝, 阿部修, 山末英典, 笠井清登, 加藤進昌, 岩田信恵, 辻省次

Cognition and Dementia　4　(2)　2005

ISSN： 1346-8685
生理的加齢性変化:SPMを用いた拡散テンソル解析

阿部修, 山末英典, 山田晴耕, 菅心, 青木茂樹, 笠井清登, 増谷佳孝, 加藤進昌, 大友邦

日本医学放射線学会学術集会抄録集　64th　2005

ISSN： 0048-0428
汎用性を持たせたMRAによる脳動脈りゅう自動検出システム

増本智彦, 増谷佳孝, 林直人, 青木茂樹, 大友邦

日本放射線技術学会総会学術大会予稿集　61st　2005

ISSN： 1884-7846
dTV-II:拡散MRIによる白質線維モデリングのための統合された画像解析・可視化システム

増谷佳孝, 青木茂樹, 阿部修, 大友邦

日本放射線技術学会総会学術大会予稿集　61st　2005

ISSN： 1884-7846
対話的血管モデリングシステムの開発と血管解析への応用

二田孝靖, 増谷佳孝, 林直人, 井野賢司, 西田克次, 美馬和男, 大友邦

日本放射線技術学会総会学術大会予稿集　61st　2005

ISSN： 1884-7846
MRI最新活用マニュアルテクニカル生活習慣病を診断する MRAデータを用いたCADの現状-脳動脈りゅうの自動検出システムの開発

増本智彦, 増谷佳孝, 林直人

Digital Medicine　6　(1)　2005

ISSN： 1345-3351
動径基底関数を用いたベクトル場補間による拡散テンソルtractography

伊藤大輔, 青木茂樹, 井野賢次, 吉田まり子, 増谷佳孝

日本医学放射線学会学術集会抄録集　64th　2005

ISSN： 0048-0428
脳変性脱髄疾患のMRI診断:新しい疾患概念に基づいて変性疾患痴呆を主体とする疾患

大久保敏之, 山田晴耕, 森墾, 増本智彦, 増谷佳孝, 阿部修, 林直人, 青木茂樹, 大友邦

臨床画像　21　(3)　2005

ISSN： 0911-1069
拡散テンソル多軸計測による拡散計測の基礎検討

椛沢宏之, 阿部修, 増谷佳孝, 青木茂樹, 大友邦

日本医学放射線学会学術集会抄録集　64th　2005

ISSN： 0048-0428
汎用性を持たせたMRAによる脳動脈りゅう自動検出システム

増本智彦, 増谷佳孝, 林直人, 青木茂樹, 大友邦

日本医学放射線学会学術集会抄録集　64th　2005

ISSN： 0048-0428
拡散テンソルトラクトグラフィによる錐体路体部位局在の検討

岩田信恵, 青木茂樹, 寺尾安生, 阿部修, 増谷佳孝, 辻省次, 宇川義一

臨床神経生理学　33　(5)　2005

ISSN： 1345-7101
腕神経叢損傷患者におけるfMRI(第3報)

吉川健啓, 林直人, 田尻康人, 青木茂樹, 阿部修, 増谷佳孝, 増本智彦, 山田晴耕, 森墾

日本医学放射線学会学術集会抄録集　64th　2005

ISSN： 0048-0428
3D画像の臨床的有用性読影における3D画像の有用性

林直人, 井野賢司, 美馬和男, 大友邦, 増谷佳孝

Innervision　20　(5)　2005

ISSN： 0913-8919
dTV-II:拡散MRIによる白質線維モデリングのための統合された画像解析・可視化システム

増谷佳孝, 青木茂樹, 阿部修, 大友邦

日本医学放射線学会学術集会抄録集　64th　2005

ISSN： 0048-0428
神経線維の術中追跡可能な手術ナビゲーションシステム:ファントムを用いた基礎実験

渡辺慎, 増谷佳孝, 青木茂樹, 阿部修, 森墾, 林直人, 増本智彦, 山田晴耕, 大友邦

日本医学放射線学会学術集会抄録集　64th　2005

ISSN： 0048-0428
神経線維の術中追跡可能な手術ナビゲーションシステム:ファントムを用いた基礎実験

渡辺慎, 増谷佳孝, 青木茂樹, 阿部修, 森墾, 林直人, 増本智彦, 山田晴耕, 大友邦

日本放射線技術学会総会学術大会予稿集　61st　2005

ISSN： 1884-7846
有限要素法と可変形ボリュームレンダリングによる肝臓変形シミュレーションシステム

増谷佳孝, 石井宏一

画像ラボ　16　(2)　2005

ISSN： 0915-6755
Fundamentals of MR Diffusion-weighted Imaging

増谷佳孝, 増谷佳孝

日獨医報　50　(4)　2005

ISSN： 0912-0351
線維方向ベクトル場の補間に基づく新しい脳白質線維追跡手法

井野賢司, 増谷佳孝, 青木茂樹, 渡辺靖志, 佐竹芳朗, 美馬和男, 大友邦

日本放射線技術学会総会学術大会予稿集　61st　2005

ISSN： 1884-7846
Functional magnetic resonance imaging- and magnetoencephalography-based brain mapping for identifying language functions and its validation by electrocortical stimulation.

K Kamada, K Kawai, Y Masutani, S Aoki, T Kirino

EPILEPSIA　46　16-17　2005

ISSN： 0013-9580
Basic Principle of Diffusion-weighted Body Imaging

ABE Osamu, WATANABE Yasushi, AOKI Shigeki, MASUTANI Yoshitaka, OHTOMO Kuni

日本磁気共鳴医学会雑誌　25　(4)　198-209　2005/01

ISSN： 0914-9457
Intra-Operative Fiber Stimulation for Validation of Neuronavigation based on Diffusion Tensor Tractography and Development of Navigation System with Intra-Operative Fiber Tracking Function

KAMADA K., MASUTANI Y., AOKI S., MORITA A, KIRINO T

6　(3)　363-364　2004/12/30

ISSN： 1344-9486
Diffusion tensor tractography

AOKI Shigeki, MASUTANI Yoshitaka, KUNIMATSU Akira, ABE Osamu

脳卒中　26　(4)　561-566　2004/12/25

ISSN： 0912-0726
Diffusion property following functional hemispherectomy in hemimegalencephaly (vol 45, pg 778, 2004)

H Mori, S Aoki, O Abe, N Hayashi, Y Masutani, K Ohtomo, S Oya, A Morita

ACTA RADIOLOGICA　45　(8)　886-886　2004/12

DOI： 10.1080/02841850410009729 　

ISSN： 0284-1851
A New Fiber Tracking Method based on Vector Field Reconstruction Excepting Fiber Crossing Area in MR Diffusion Tensor Images

MASUTANI Yoshitaka, AOKI Shigeki, ABE Osamu, OHTOMO Kuni

Medical Imaging Technology　22　(5)　243-249　2004/12
Publisher: The Japanese Society of Medical Imaging Technology
DOI： 10.11409/mit.22.243 　

ISSN： 0288-450X
Accelerated Registration of Volume Data Based on Graphics Hardware : Comparison with Software Based Method

MATSUO Yoshie, SHIMIZU Akinobu, KOBATAKE Hidefumi, MASUTANI Yoshitaka

IEICE technical report.　103　(598)　71-76　2004/11
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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In this paper, an accelerated registration method based on graphics hardware was compared with the conventional software based system. We applied both of the systems to a pair of three dimensional CT image and PET image and evaluated accuracy of registration and computational cost. Several experiments followed by discussion were conducted so as to assess influence of number of slice images per axis and number of bit allocated for gray values used for registration.
Development of Surgical Simulator with High Quality Visualization Based on Finite Element Method, and Deformable Volume Rendering

INOUE Yusuke, MASUTANI Yoshitaka, ISHII Koichi, KUMAI Nori, KIMURA Fumihiko, SAKUMA Ichiro

The Transactions of the Institute of Electronics,Information and Communication Engineers.　87　(1)　271-280　2004/10/10
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0915-1923
Principles of diffusion-weighted MR imaging and application to clinical neurology

OKUBO Toshiyuki, AOKI Shigeki, ABE Osamu, MASUTANI Yoshitaka, OHTOMO Kuni, HORI Masaaki, ISHIGAME Keiichi, ARAKI Tsutomu

Rinsho Shinkeigaku　44　(11)　954-956　2004/10/10
Publisher: 日本神経学会
ISSN： 0009-918X
Optic radiation tractographyと皮質VEPモニタリング融合によるFunctional Neuronavigation

鎌田恭輔, 藤堂具紀, 川合謙介, 青木茂樹, 増谷佳孝, 森田明夫, 桐野高明

臨床神経生理学　32　(5)　566-566　2004/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101
拡散テンソル (特集 MRIの最新トピックス)

大久保敏之, 青木茂樹, 増谷佳孝

映像情報medical　36　(10)　1062-1068,1045〜1047　2004/09
Publisher: 産業開発機構
ISSN： 1346-1354
Extraction and Modeling of White Matter Fiber Tract based on Diffusion MR Image Analysis

Human interface　6　(3)　167-172　2004/08/25
Publisher: ヒュ-マンインタフェ-ス学会
ISSN： 1344-7254
新しい医療技術 MRIによる神経系のtractography

渡辺慎, 阿部修, 増谷佳孝

整形・災害外科　47　(9)　1089-1094　2004/08
Publisher: 金原出版
ISSN： 0387-4095
Isotropic and Anisotropic Measurement of Pattern Size based on Greyscale Morphology

MASUTANI Y.

Technical report of IEICE. PRMU　104　(89)　47-52　2004/05/21
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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In this abstract, methods biased on local pattern spectrum in greyscale morphology are proposed for measurement of pattern size, which can be in isotropic manner by using spherical structuring element and in anisotropic manner by using multi-directional linear structuring elements. Measured size defined here is an attribute based on local pattern spectrum at a pixel/voxel and is given for each. For the anisotropic manner, it is shown that pattern classification to blob, linear, and planar types is feasible by approximating directional pattern size profile as quadratic form of symmetric matrix, similar to a method based on eigen values of Hessian matrix. By using synthetic data and 3D medical image data, several experiments were performed in terms of size estimation and direction estimation. Based on comparison with other related methods, advantages and disadvantages are discussed.
Diffusion tensor tractography

青木茂樹, 増谷佳孝, 国松聡, 阿部修

脳卒中　26　(4)　2004

ISSN： 0912-0726
Diffusion Tensor Tractographyに基づくニューロナビゲーションの術中Fiber Stimulationによる検証および術中Fiber Tracking可能なナビゲーションシステムの開発

鎌田恭輔, 増谷佳孝, 青木茂樹, 森田明夫, 桐野高明

コンピュータ支援画像診断学会大会・日本コンピュータ外科学会大会合同論文集　14th-13th　2004
Automated liver segmentation in X-ray CT images and shape modeling based on boundary shape feature extraction and shape reconstruction by using radial basis function

増谷佳孝, 木村文彦, 佐久間一郎

コンピュータ支援画像診断学会論文誌(Web)　8　(1_2)　2004

ISSN： 1347-9245
腕神経叢損傷患者におけるfMRI(第1報)

吉川健啓, 林直人, 田尻康人, 青木茂樹, 阿部修, 増谷佳孝, 増本智彦, 国松聡, 森墾

日本医学放射線学会雑誌　64　(2)　2004

ISSN： 0048-0428
マルチスライスCTとMRIの臨床応用内科医に必要なCTとMRIの基礎知識 MRIの進歩

阿部修, 青木茂樹, 増谷佳孝, 林直人, 増本智彦, 山田晴耕, 森墾, 大友邦

診断と治療　92　(9)　2004

ISSN： 0370-999X
MR拡散テンソル画像解析用フリーソフト:diffusion TENSOR Visualizer

増谷佳孝, 青木茂樹, 阿部修, 大友邦

日本医学放射線学会雑誌　64　(2)　2004

ISSN： 0048-0428
標準脳とのレジストレーションを併用した半自動拡散テンソルトラクトグラフィーの有用性の検討

渡谷岳行, 青木茂樹, 増谷佳孝, 森墾, 吉田まり子, 山田晴耕, 岩田信恵, 阿部修, 林直人

日本磁気共鳴医学会雑誌　24　(Supplement(Sept))　2004

ISSN： 0914-9457
拡散テンソルトラクトグラフィによるALS患者の白質路評価

岩田信恵, 青木茂樹, 増谷佳孝, 宇川義一, 郭伸, 辻省次

日本神経学会総会プログラム・抄録集　45th　2004
腕神経叢損傷患者におけるfMRI(第2報)

吉川健啓, 林直人, 田尻康人, 青木茂樹, 阿部修, 増谷佳孝, 増木智彦, 佐竹芳朗, 渡辺靖志

日本磁気共鳴医学会雑誌　24　(Supplement(Sept))　2004

ISSN： 0914-9457
III MRI(ハード&ソフト)の最新技術動向 4.MRAを用いた脳動脈りゅうのコンピュータ支援診断(CAD)

増本智彦, 増谷佳孝, 林直人, 高野直樹, 松本和彦

Innervision　19　(9)　2004

ISSN： 0913-8919
MR拡散テンソル画像解析用フリーソフト:diffusion TENSOR Visualizer

増谷佳孝, 青木茂樹, 阿部修, 大友邦

日本放射線技術学会総会学術大会予稿集　60th　2004

ISSN： 1884-7846
術中モニタリングによるEloquent fiber tractographyの検証とその臨床応用

鎌田恭輔, 青木茂樹, 井野賢司, 森田明夫, 増谷佳孝, 桐野高明

日本磁気共鳴医学会雑誌　24　(Supplement(Sept))　2004

ISSN： 0914-9457
急性期脳梗塞の予後評価におけるdiffusion tensor tractographyの有用性の検討

中田安浩, 堀正明, 青木真一, 安達木綿子, 大久保敏之, 国松聡, 増谷佳孝, 荒木力

日本磁気共鳴医学会雑誌　24　(Supplement(Sept))　2004

ISSN： 0914-9457
拡散テンソル画像法の基礎と臨床-拡散テンソルMR画像法はこう使える-拡散テンソルtractography Tracking理論,ソフト実演

増谷佳孝

日本神経放射線学会プログラム・抄録集　33rd　2004
MRAデータを用いた脳動脈りゅうの自動検出システムの開発

増本智彦, 増谷佳孝, 林直人, 青木茂樹, 大友邦

日本放射線技術学会総会学術大会予稿集　60th　2004

ISSN： 1884-7846
頚動脈狭窄症における血管内腔辺縁周長の検討

国松聡, 増谷佳孝, 青木茂樹, 林直人, 阿部修, 増本智彦, 山田晴耕, 吉川健啓, 渡辺慎

日本医学放射線学会雑誌　64　(2)　2004

ISSN： 0048-0428
術中ナビゲーションを目的としたtractographyのレジストレーション

井野賢司, 佐竹芳朗, 美馬和男, 増谷佳孝, 青木茂樹, 大友邦, 鎌田恭輔

日本放射線技術学会総会学術大会予稿集　60th　2004

ISSN： 1884-7846
グラフィクスハードウェアを用いた3次元画像データの高速位置合わせ法-高次多項式に基づく変形の導入-

冨田直史, 松尾良恵, 清水昭伸, 小畑秀文, 増谷佳孝

日本ME学会大会論文集　43rd　2004
多方向拡散MRイメージングによる白質線維モデリングおよび統合された画像解析・可視化システム:-診断および放射線治療・外科手術への応用-

増谷佳孝, 青木茂樹, 阿部修, 林直人, 増本智彦, 大友邦

コンピュータ支援画像診断学会大会・日本コンピュータ外科学会大会合同論文集　14th-13th　2004
Magnetic resonance tractography of central nervous system

渡辺慎, 阿部修, 増谷佳孝, 山田晴耕, 青木茂樹, 大友邦

整形・災害外科　47　(9)　2004

ISSN： 0387-4095
脳脊髄液近傍TractographyにおけるFLAIR-DTIの有用性

佐竹芳朗, 渡辺靖志, 椛沢宏之, 井野賢司, 青木茂樹, 増谷佳孝, 阿部修, 増本智彦, 西田克次

日本磁気共鳴医学会雑誌　24　(Supplement(Sept))　2004

ISSN： 0914-9457
ALS早期診断のための新しい展開拡散テンソルMRIによる検討

阿部修, 青木茂樹, 増谷佳孝, 大友邦

月刊神経内科　60　(3)　2004

ISSN： 0386-9709
tractographyによる神経こう腫を通過する皮質脊髄路の描出

赤井宏行, 増谷佳孝, 森墾, 青木茂樹, 林直人, 阿部修, 増本智彦, 飯島明, 森田明夫

日本医学放射線学会雑誌　64　(7)　2004

ISSN： 0048-0428
High Angular Resolution Diffusion-weighted imagingの検討

椛沢宏之, 増谷佳孝, 阿部修, 青木茂樹, 大友邦, 渡辺靖志

日本磁気共鳴医学会雑誌　24　(Supplement(Sept))　2004

ISSN： 0914-9457
高異方性を示す拡散テンソルの主方向の補間ベクトル場に基づく脳白質線維追跡

増谷佳孝, 青木茂樹, 阿部修, 大友邦

日本医用画像工学会大会予稿集(CD-ROM)　23rd　2004

ISSN： 0288-450X
片側巨脳症に対する半球離断術前後の拡散画像

森懇, 増谷佳孝, 大宅宗一, 川合謙介, 青木茂樹, 林直人, 阿部修, 増本智彦, 国松聡

日本神経放射線学会プログラム・抄録集　33rd　2004
MRAデータを用いた脳動脈りゅうの自動検出システムの開発

増本智彦, 増谷佳孝, 林直人, 青木茂樹, 大友邦

日本医学放射線学会雑誌　64　(2)　2004

ISSN： 0048-0428
拡散テンソルトラクトグラフィによるALS患者の白質路評価

岩田信恵, 青木茂樹, 増谷佳孝, 宇川義一, 郭伸, 辻省次

臨床神経学　44　(12)　2004

ISSN： 0009-918X
筋萎縮性側索硬化症における全脳拡散異方性解析:SPMによる検討

阿部修, 青木茂樹, 山田晴耕, 国松聡, 林直人, 増本智彦, 森墾, 渡辺慎, 増谷佳孝

日本医学放射線学会雑誌　64　(2)　2004

ISSN： 0048-0428
ALS患者の拡散テンソル画像:tractography利用の半自動ROIによる検討

青木茂樹, 岩田信恵, 増谷佳孝, 阿部修, 宇川義一, 増本智彦, 森懇, 林直人, 辻省次

日本神経放射線学会プログラム・抄録集　33rd　2004
骨モデルマッチングによるMRI画像からの手骨位置姿勢同定

鴨島里実, 宮田なつき, 太田順, 持丸正明, 河内まき子, 増谷佳孝

精密工学会大会学術講演会講演論文集　2004　2004
心的外傷後ストレス障害における拡散テンソル解析-SPMを用いた検討

阿部修, 山末英典, 山田晴耕, 笠井清登, 青木茂樹, 林直人, 増谷佳孝, 福田倫明, 加藤進昌

日本磁気共鳴医学会雑誌　24　(Supplement(Sept))　2004

ISSN： 0914-9457
3D画像医学の臨床脳外科領域の診断と治療(脳腫よう)MR拡散テンソルイメージングによるFiber Tracking

増谷佳孝

日本臨床　62　(4)　2004

ISSN： 0047-1852
脳動静脈奇形患者のDiffusion Tensor Tractography

伊藤大輔, 青木茂樹, 増谷佳孝, 丸山圭介, 森墾, 増本智彦, 阿部修, 林直人

日本磁気共鳴医学会雑誌　24　(Supplement(Sept))　2004

ISSN： 0914-9457
線維方向ベクトル場の補間に基づく新しい脳白質線維追跡手法

井野賢司, 増谷佳孝, 青木茂樹, 阿倍修, 林直人, 佐竹芳朗, 美馬和男, 大友邦

日本磁気共鳴医学会雑誌　24　(Supplement(Sept))　2004

ISSN： 0914-9457
Tractography手法の検証を目的とした繊維ファントムの作成

渡辺慎, 増谷佳孝, 青木茂樹, 阿部修, 森墾, 林直人, 増本智彦, 井野賢司, 渡辺靖志

日本磁気共鳴医学会雑誌　24　(Supplement(Sept))　2004

ISSN： 0914-9457
感染症の画像診断:最近のトピックスプリオン病クロイツフェルト・ヤコブ病(変異型)など

森墾, 青木茂樹, 林直人, 阿部修, 増谷佳孝, 増本智彦, 山田晴耕, 国松聡, 吉川健啓

臨床画像　20　(5)　2004

ISSN： 0911-1069
拡散テンソルtractography (Routine Clinical MRI 2004 Book) -- (特集論文)

青木茂樹, 増谷佳孝, 阿部修

映像情報medical　35　(15)　11-14,64〜69　2003/12
Publisher: 産業開発機構
ISSN： 1346-1354
Feasibility of a curvature-based enhanced display system for detecting cerebral aneurysms in MR angiography

Naoto Hayashi, Yoshitaka Masutani, Tomohiko Masumoto, Harushi Mori, Akira Kunimatsu, Osamu Abe, Shigeki Aoki, Kuni Ohtomo, Naoki Takano, Kazuhiko Matsumoto

Magnetic Resonance in Medical Sciences　2　(1)　29-36　2003/12/01
Publisher: Japanese Society for Magnetic Resonance in Medicine
DOI： 10.2463/mrms.2.29 　

ISSN： 1347-3182
構音と顔面運動野

寺尾安生, 宇川義一, 山本知孝, 清水潤, 桜井靖久, 増本智彦, 阿部修, 増谷佳孝, 青木茂樹, 辻省次

臨床神経学　43　(12)　938-938　2003/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X
tractographyによる皮質脊髄路描出法の比較検討 : one-ROI法とtwo-Roi法

森墾, 増谷佳孝, 青木茂樹, 阿部修, 林直人, 増本智彦, 山田晴耕, 吉川健啓, 國松聡, 大友邦, 椛沢宏之

日本醫學放射線學會雜誌　63　(1)　51-53　2003/12

ISSN： 0048-0428
Configuration of Color and Opacity Function in Surgical Simulator based on Deformable Volume Rendering and FEM

MASUTANI Y., INOUE Y., ISHII K., KIMURA F., SAKUMA I.

IEICE technical report.　103　(319)　51-56　2003/09/19
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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For our surgical simulation system with fast deformable volume-rendering based on 3D texture, configuration method of color-opacity function of volume-rendering was investigated. By using radial basis function interpolation with several color-opacity control points, an interactive and easy to operate configuration method was developed for 2D color-opacity table based on dual phase X-ray CT angiography data. In addition, feasibility study was performed based on a clinical data set.
Synthetic Data Study for Validation of Improved Tracking Method based on Diffusion Anisotropy in MR-DTI White Matter Fiber Tracking

MASUTANI Y., WATANABE M., AOKI S., OHTOMO K., KABASAWA H.

IEICE technical report.　103　(319)　33-37　2003/09/19
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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For white matter fiber tracking based on MR diffusion tensor images, we already proposed a new method based on local diffusion anisotropy, which improves tracking performance at fiber crossing. In this study, we validated the method by using synthetic data in which several imaging parameters can be virtually controlled.
Diffusion tensor imaging in the central nervous system

30　(6)　64-67　2003/06
Publisher: エム・イー振興協会 ; 1975-
ISSN： 0910-7991
MR imaging of ischemic penumbra

Osamu Abe, Shigeki Aoki, Ichiro Shirouzu, Akira Kunimatsu, Naoto Hayashi, Tomohiko Masumoto, Harushi Mori, Haruyasu Yamada, Makoto Watanabe, Yoshitaka Masutani, Kuni Ohtomo

European Journal of Radiology　46　(1)　67-78　2003/04/01

DOI： 10.1016/S0720-048X(02)00329-7 　

ISSN： 0720-048X
【外科領域を中心とするロボティックシステムの開発】手術ロボティックシステム開発プロジェクト

佐久間一郎, 小林英津子, 辻隆之, 陳献, 久田俊明, 増谷佳孝, 木村文彦, 佐々木健, 板生清, 岡田昌史, 中村仁彦, 波多伸彦, 土肥健純

日本コンピュータ外科学会誌　4　(4)　331-338　2003/03
Publisher: (一社)日本コンピュータ外科学会
DOI： 10.5759/jscas1999.4.331 　

ISSN： 1344-9486
拡散テンソルtractography

青木茂樹, 増谷佳孝, 阿部修, 国松聡, 森墾, 山田晴耕, 井野賢司, 椛沢宏之

映像情報Medical　35　(15)　2003

ISSN： 1346-1354
錐体路及び錐体路近傍脳梗塞における錐体路拡散異方性の評価拡散テンソルtractographyを用いて

国松聡, 青木茂樹, 増谷佳孝, 阿部修, 林直人, 増本智彦, 森墾, 山田晴耕, 大友邦

日本医学放射線学会雑誌　63　(2)　2003

ISSN： 0048-0428
イラスト-クリニカルテクニック Diffusion tensor tractography

青木茂樹, 増谷佳孝, 阿部修, 国松聡, 森墾, 山田晴耕, 井野賢司, 森田明夫

Clinical Neuroscience　21　(9)　2003

ISSN： 0289-0585
MR-DTIにおけるfiber tractography

増谷佳孝

日本医学放射線学会雑誌　63　(5)　2003

ISSN： 0048-0428
画像最前線 DTI(拡散テンソル画像)による神経線維の走行の描出

増谷佳孝, 青木茂樹, 阿部修, 大友邦

脳神経外科速報　13　(5)　2003

ISSN： 0917-1495
拡散テンソルTractographyの小児疾患における有用性の検討

酒井美緒, 大場洋, 古井滋, 工富公子, 青木茂樹, 増谷佳孝, 阿部修

日本医学放射線学会雑誌　63　(2)　2003

ISSN： 0048-0428
Step up MRI 2003 III MRIの最新技術動向 3. 脳白質線維の可視化(トラクトグラフィ)手法

増谷佳孝

Innervision　18　(9)　2003

ISSN： 0913-8919
van der Knaap病のMRI所見と拡散テンソルtractography

工富公子, 大場洋, 古井滋, 酒井美緒, 青木茂樹, 増谷佳孝, 阿部修

日本医学放射線学会雑誌　63　(2)　2003

ISSN： 0048-0428
拡散テンソルTractographyの小児疾患における有用性の検討

大場洋, 仲本なつ恵, 藤井靖史, 藤田靖子, 疋田敏之, 金子衣野, 児玉浩子, 青木茂樹, 増谷佳孝

日本小児放射線学会雑誌　19　2003

ISSN： 0918-8487
PCワークステーションによるMR拡散テンソル解析・表示システム

増谷佳孝, 青木茂樹, 阿部修, 森墾, 増本智彦, 林直人, 大友邦, 椛沢宏之

日本医学放射線学会雑誌　63　(2)　2003

ISSN： 0048-0428
画像診断2003 到達点と将来展望 I 検査法の到達点と将来展望 3Dイメージングにおける表示技術とコンピュータ支援診断

増谷佳孝

Pharma Medica　21　(1)　2003

ISSN： 0289-5803
錐体路近傍脳腫ようの拡散テンソルtractography FA変化と臨床症状との相関

山田晴耕, 増谷佳孝, 青木茂樹, 阿部修, 国松聡, 森墾, 増本智彦, 林直人, 椛沢宏之

日本医学放射線学会雑誌　63　(2)　2003

ISSN： 0048-0428
脊髄神経根に増強効果を認めた筋萎縮性側索硬化症(ALS)の2例

岡本紘明, 森墾, 青木茂樹, 林直人, 阿部修, 増谷佳孝, 増本智彦, 平川美菜子, 宇川義一

日本神経放射線学会プログラム・抄録集　32nd　2003
これからの脳腫ようの画像診断拡散テンソル画像

山田晴耕, 阿部修, 増谷佳孝, 青木茂樹, 吉川健啓, 国松聡, 森墾, 増本智彦, 椛沢宏之

臨床画像　19　(10)　2003

ISSN： 0911-1069
MRAデータの3次元画像解析による脳動脈りゅうのコンヒュータ支援診断

増谷佳孝

日本医学放射線学会雑誌　63　(2)　2003

ISSN： 0048-0428
MDCTを用いた血管中心線/領域自動抽出による頚動脈狭窄の診断血管造影との比較

国松聡, 青木茂樹, 増谷佳孝, 林直人, 阿部修, 増本智彦, 森墾, 渡辺慎, 西蔭誠二

日本医学放射線学会雑誌　63　(2)　2003

ISSN： 0048-0428
診断論理と直感:画像診断における認知と解釈

南学, 増谷佳孝, 大友邦

日本医用画像工学会大会予稿集(CD-ROM)　22nd　2003

ISSN： 0288-450X
錐体路近傍梗塞の拡散テンソル3D tractography

青木茂樹, 国松聡, 増谷佳孝, 阿部修, 林直人, 森田明夫, 津本学

脳卒中　25　(1)　2003

ISSN： 0912-0726
Diffusion Tensor Tractography.

青木茂樹, 増谷佳孝, 阿部修, 国松聡, 森墾, 山田晴耕, 井野賢司

画像診断　23　(11)　2003

ISSN： 0285-0524
ファントムを用いたDTI tractographyの検証拡散異方性を考慮したtracking方向改善の試み

渡辺慎, 増谷佳孝, 青木茂樹, 阿部修, 森墾, 林直人, 増本智彦, 大友邦, 椛沢宏之

日本医学放射線学会雑誌　63　(2)　2003

ISSN： 0048-0428
Navigation manipulator for orthopedic surgery : 2^<nd> report : study of User-interface

MASAMUNE Ken, TANAKA Masashi, NAGANOU Hiroaki, SEICHI Atsushi, MASUTANI Yoshitaka, NAKAJIMA Susumu

Journal of Japan Society of Computer Aided Surgery : J.JSCAS　4　(3)　183-184　2002/12/30

ISSN： 1344-9486
Accelerated Registration of Medical Images Based on Graphics Hardware

MASUTANI Yoshitaka, FUJIMORI Tomoyuki, YOSHIKAWA Takaharu, SUZUKI Hiromasa, KIMURA Fumihiko

IPSJ SIG Notes　2002　(109)　65-70　2002/12/20
Publisher: Information Processing Society of Japan (IPSJ)
ISSN： 0919-6072

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As seen in the literatures, multi-modal medical image registration, such as MRI and X-ray CT, or time series of image data, is a time-consuming process. In this study, we propose a new method for 2D/3D medical image registration, which is based on graphics hardware for accelerated texture drawing, and discuss on the advantages and the disadvantages of the method. In the experiments, a data set of MR diffusion tensor image by the echo planar imaging technique is used for registration. On the basis of the results in the experiments under several parameters of similarity measure and drawing size, the influence of the registration parameters are studied.
拡張現実感を用いた手術支援用ナビゲーション断層画像表示システム

正宗賢, 松家大介, 石川達也, 杉浦円, 川俣貴一, 村垣善浩, 丸山隆志, 平井信行, 鈴川浩一, 堀智勝, 杉浦誠, 伊関洋, 増谷佳孝

日本コンピュータ外科学会誌　4　(3)　231-232　2002/12
Publisher: (一社)日本コンピュータ外科学会
ISSN： 1344-9486
MRIによる腫瘍イメージングの進歩:脳腫瘍を中心に (特集画像診断と放射線治療の統合化に向けて) -- (腫瘍イメージングの進歩)

青木茂樹, 増谷佳孝, 大友邦

映像情報medical　34　(14)　1322-1328,1302〜1303　2002/11
Publisher: 産業開発機構
ISSN： 1346-1354
Diffusion tensor, anisotropy-color-coded, 3D tractography in neuropediatrics

H Yamada, S Aoki, O Abe, Y Masutani, N Hayashi, K Ohtomo

RADIOLOGY　225　141-141　2002/11

ISSN： 0033-8419
Diffusion tensor imaging of cerebral infarction: Analysis of ADC and DTI scalar metrics (fractional anisotropy and eigenvalues)

T Yoshikawa, S Aoki, Y Masutani, O Abe, H Mori, K Ohtomo

RADIOLOGY　225　278-279　2002/11

ISSN： 0033-8419
Tractography of Brain White Matter Tracts Based on Analysis of MR Diffusion Tensor Data : Selective Tractography With Tracking Reliability

MASUTANI Yoshitaka, ABE Osamu, AOKI Shigeki, MORI Harushi, MASUMOTO Tomohiko, YOSHIKAWA Takeharu, OHTOMO Kuni, HAYASHI Naoto, KABASAWA Hiroyuki

Medical Imaging Technology　20　(5)　584-592　2002/09/25
Publisher: The Japanese Society of Medical Imaging Technology
DOI： 10.11409/mit.20.584 　

ISSN： 0288-450X
Image Analysis and Visualization in MR Diffusion Tensor Data ; Tractography Based on Diffusion Tensor Tracking, and Other Techniques

MASUTANI Yoshitaka

Journal of Japan Society of Computer Aided Surgery　4　(1)　5-12　2002/06/30
Publisher: 日本コンピュ-タ外科学会
ISSN： 1344-9486
MRI-Diffusion tensor imaging

29　(6)　72-75　2002/06
Publisher: エム・イー振興協会 ; 1975-
ISSN： 0910-7991
Evaluation of PROPELLER MR Imaging: Preliminary Experiences

Satake Yoshirou, Watanabe Yasushi, Yoshikawa Takeharu, Hayashi Naoto, Masumoto Tomohiko, Masutani Yoshitaka, Abe Osamu, Aoki Shigeki, Mori Harushi, Ohtomo Kuni, Kabasawa Hiroyuki

日本医学放射線学会雑誌　62　(6)　287-289　2002/05/25
Publisher: 日本医学放射線学会
ISSN： 0048-0428
脳梗塞のDiffusion Tensor Imaging FA,eigenvaluesによる分析

青木茂樹, 石亀慶一, 阿部修, 吉川健啓, 増谷佳孝, 林直人, 大友邦, 堀正明, 大久保敏之, 荒木力

脳卒中　24　(1)　152-152　2002/04
Publisher: (一社)日本脳卒中学会
ISSN： 0912-0726
グラフィックス・ハードウェアを用いた物体断面形状生成

藤森智行, 川地克明, 鈴木宏正, 増谷佳孝, 木村文彦

精密工学会大会学術講演会講演論文集　2002　(1)　263-263　2002/03/01
三次元医用画像における形状特徴の抽出とその肝臓形状モデリングへの応用〈第二報〉境界形状特徴点の識別とRadial Basis Functionによる形状再構成

増谷佳孝, 木村文彦, 佐久間一郎

コンピュータ支援画像診断学会大会・日本コンピュータ外科学会大会合同論文集　12th-11th　2002
PROPELLER MRI その原理と応用

森墾, 青木茂樹, 阿部修, 増谷佳孝, 増本智彦, 林直人, 吉川健啓, 大友邦, 椛沢宏之

映像情報Medical　34　(16)　2002

ISSN： 1346-1354
Improvement of tracking direction based on diffusion anisotropy in diffusion tensor MR imaging

増谷佳孝, 阿部修, 青木茂樹, 森墾, 増本智彦, 吉川健啓, 大友邦, 林直人, 椛沢宏之

Medical Imaging Technology　20　(4,Pt.2)　2002

ISSN： 0288-450X
境界情報を持つボクセルモデルの生成手法

玉置泰啓, 鈴木宏正, 藤森智行, 増谷佳孝, 木村文彦

精密工学会大会学術講演会講演論文集　2002　(2)　15-15　2002

DOI： 10.11522/pscjspe.2002A.0.19.0 　
グラフィックスハードウェアを用いたボリュームデータと半透明ポリゴンの混合表示

藤森智行, 川地克明, 鈴木宏正, 増谷佳孝, 木村文彦

精密工学会大会学術講演会講演論文集　2002　(2)　19-19　2002

DOI： 10.11522/pscjspe.2002A.0.24.0 　
Diffusion-weighted Imaging : Clinical Application

ABE Osamu, MASUTANI Yoshitaka, AOKI Shigeki, KUNIMATSU Akira, HAYASHI Naoto, MASUMOTO Tomohiko, MORI Harushi, YAMADA Haruyasu, YOSHIKAWA Takeharu, WATANABE Makoto, KABASAWA Hiroyuki, OHTOMO Kuni

日本磁気共鳴医学会雑誌　22　(4)　191-203　2002/01

ISSN： 0914-9457
Deformable Organ Modeling and Non-Rigid Registration for Surgical Support

MASUTANI Y., FURUSHIRO N., KIMURA F., SAKUMA I.

3　(3)　135-136　2001/12/30

ISSN： 1344-9486
術中の表面形状計測とその手術ナビゲーションへの応用計測範囲のレジストレーション誤差への影響の検討

古城直道, 増谷佳孝, 小林英津子, 佐久間一郎, 木村文彦, 辻隆之, 土肥健純, 稲田紘

日本コンピュータ外科学会誌　3　(3)　137-138　2001/12
Publisher: (一社)日本コンピュータ外科学会
ISSN： 1344-9486
Deformable Organ Modeling for Surgical Simulation and Navigation

MASUTANI Yoshitaka, KIMURA Fumihiko

IEICE technical report.　101　(239)　79-86　2001/07/20
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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A new representation technique of volumetric shape deformation, modally controlled free form deformation, was developed for surgical navigation and for non-rigid registration of a pre-operative patient liver model and intra-operative range data of partial liver surface. The technique is based on a free form deformation (FFD) and a modal representation of shape deformation. The FFD control points were moved in several artificial modes, such as rigid motion, bending, and twisting, which were represented by 21 parameters. Registration was performed by searching the optimal parameter set. Based on the consideration of the error factors, registration experiments were performed by using a patient model and synthesized range data to evaluate registration accuracy.
三次元医用画像における形状特徴の抽出とその肝臓形状モデリングへの応用 (第1報)

増谷佳孝

第11回CADM講演論文集, 2001　201-202　2001
Computer-Assisted Diagnosis in CT images based on Volumetric Image Analysis

MASUTANI Yoshitaka

2　(3)　93-93　2000/12/30

ISSN： 1344-9486
New operation support system by Volumegraph projecting functional localization of the brain.

村垣善浩, 伊関洋, 長尾建樹, 川崎浩遠, 高倉公明, 小野智也, 増谷佳孝, 土肥健純, 岩原誠

日本手術医学会誌　19　(2)　247-249　1998/05/31

ISSN： 1340-8593
Functional Navigation System-Functional mapを投影したVolumegraphによる脳手術支援システム

村垣善浩, 伊関洋, 小野智也, 増谷佳孝, 岩原誠, 長尾建樹, 川崎浩遠, 谷川達也, 土肥健純, 高倉公朋

日本脳神経外科学会総会抄録集　56回　209-209　1997/10
Publisher: (一社)日本脳神経外科学会
ISSN： 1347-9059
Development of Volumegraphscope for Overlayed Three-dimensional Image (Volumegraph) Navigation

ISEKI Hiroshi, MASUTANI Yoshitaka, IWAHARA Makoto, TAIRA Takaomi, KAWABATAKE Hiroko, TANIKAWA Tatsuya, KAWAMURA Hirotsune, DOHI Takeyoshi, TAKAKURA Kintomo

35　76-81　1997/09/30

ISSN： 1344-9699
Development of Three dimensional Medical Imaging System for Surgery.

土肥健純, 増谷佳孝, 正宗賢, 鈴木真

東京大学工学部総合試験所年報　56　(56)　61-65　1997/09
Publisher: 東京大学工学部総合試験所
ISSN： 0371-3067
Volumegraph

ISEKI H., MASUTANI Y., IWAHARA M., ONO T., MASAMUNE K., DOHI T., TAKAKURA K.

BME　11　(8)　3-8　1997/08/10

DOI： 10.11239/jsmbe1987.11.8_3 　

ISSN： 0913-7556 2185-5382
Extraction of brain sulcus images for brain surgical operation support.

野村知代, 片岡弘之, 増谷佳孝, 正宗賢, 鈴木真, 土肥健純, 伊関洋, 高倉公朋

精密工学会大会学術講演会講演論文集　1997　(1)　441-442　1997/03/01
Surgery using computers. Three-dimensional image navigation (Volumegraph).

伊関洋, 増谷佳孝, 岩原誠, 小野智也, 正宗賢, 土肥健純, 高倉公朋

BME　11　(8)　1997

ISSN： 0913-7556
6. Augmented Realityを応用した三次元画像合成観察による術中ナビゲーションの試み

岩原誠, 伊関洋, 高倉公朋, 増谷佳孝, 土肥健純

日本放射線技術學會雜誌　52　(9)　99-100　1996/09/20
Publisher: 社団法人日本放射線技術学会
ISSN： 0369-4305
Brain surgery operation support robot and integration of coordinate systems of preoperative medical image information.

林田真昌, 正宗賢, 増谷佳孝, 鈴木真, 土屋健純

精密工学会大会学術講演会講演論文集　1996　(1)　325-326　1996/03/01
Three-dimensional image(Volumegraph) navigation system.

伊関洋, 増谷佳孝, 岩原誠, 西由嗣, 小池秀雄, 平孝臣, 谷川達也, 河村弘庸, 高倉公朋

日本バーチャルリアリティ学会大会論文集　1　1996

ISSN： 1342-4564
Intraoperative navigation by volumegraph projection.

伊関洋, 増谷佳孝, 岩原誠, 西由嗣, 土肥健純, 高倉公朋

Clinical Neuroscience　14　(8)　1996

ISSN： 0289-0585
Computer section in neurosurgery region. Trial of stereoscopic display of organ using three-dimensional plotter technique and synthetic observation with subject.

岩原誠, 西由嗣, 鈴木直樹, 増谷佳孝, 土肥健純

中部大学総合工学研究所総合工学　8　1996

ISSN： 0915-3292
Three-dimensional image. Principles and clinical application. Cerebral nerve operation simulation.

伊関洋, 高倉公朋, 増谷佳孝, 土肥健純, 南部恭二郎

臨床放射線　41　(11)　1996

ISSN： 0009-9252
Medical science and virtual reality. Computer aided surgery(CAS).

伊関洋, 高倉公朋, 正宗賢, 増谷佳孝, 鈴木真, 土肥健純

日本機械学会通常総会講演会講演論文集　73rd　(Pt 1)　1996
Intraoperative Computer Aided Surgery System Using Note Type Workstation

MASAMUNE Ken, MASUTANI Yoshitaka, SUZUKI Makoto, DOHI Takeyoshi, ISEKI Hiroshi, TAKAKURA Kimitomo

Medical Imaging Technology　13　(3)　215-220　1995/05/25
Publisher: The Japanese Society of Medical Imaging Technology
DOI： 10.11409/mit.13.215 　

ISSN： 0288-450X
Development of Intravascular Neurosurgery Support System.

増谷佳孝, 鈴木真, 土肥健純, 山根文孝, 伊関洋, 小野由子, 小林直紀, 高倉公朋

コンピュータ支援画像診断学会大会・日本コンピュータ外科学会大会合同論文集　5th-4th　1995
Investigation for collection of data, design and production in cranioplasty with hydroxylapatite material.

川畠弘子, 伊関洋, 増谷佳孝, 波多伸彦, 平孝臣, 谷川達也, 小川哲朗, 吉田貴光, 杉本紀幸

コンピュータ支援画像診断学会大会・日本コンピュータ外科学会大会合同論文集　5th-4th　1995
Simulation of surgical approach to intracranial lesion using computer aided surgery tools(HyperCAS/NIH image) with hyperreslice.

佐藤裕之, 伊関洋, 増谷佳孝, 林基弘, 河村弘庸, 谷川達也, 高倉公朋, 土肥健純

コンピュータ支援画像診断学会大会・日本コンピュータ外科学会大会合同論文集　5th-4th　1995
Development of a Needle Insertion Manipulator for MRI guided neurosurgery.

小林英津子, 正宗賢, 増谷佳孝, 鈴木真, 土肥健純

日本ロボット学会学術講演会予稿集　13th　(2)　1995
Three-dimensional image guided navigation with function of augmented reality.

山根文孝, 伊関洋, 増谷佳孝, 岩原誠, 西由嗣, 河村弘庸, 谷川達也, 土肥健純, 高倉公朋

コンピュータ支援画像診断学会大会・日本コンピュータ外科学会大会合同論文集　5th-4th　1995
A Registration method of the catheter guided manipulator for neurosurgery using pre-operative medical image information.

正宗賢, 増谷佳孝, 小林英津子, 鈴木真, FURUKAWA C M, 伊関洋, 河村弘庸, 谷川達也, 高倉公朋

コンピュータ支援画像診断学会大会・日本コンピュータ外科学会大会合同論文集　5th-4th　1995
レーザースキャニングシステムによる眼科マイクロサージェリ

宮田和典, 岡本和年, 増谷佳孝, 土肥健純, 垣本映, 武藤一夫, 刑部安弘

医療情報学連合大会論文集　13th　1993

ISSN： 1347-8508

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Books and Other Publications 9

Multidisciplinary computational anatomy : toward integration of artificial intelligence with MCA-based medicine

Hashizume Makoto

Springer　2022

ISBN: 9789811643248
多元計算解剖学の基礎と臨床への応用

橋爪, 誠

誠文堂新光社　2018/03

ISBN: 9784416518243
Computational anatomy based on whole body imaging : basic principles of computer-assisted diagnosis and therapy

小畑, 秀文, 増谷, 佳孝

Springer　2017

ISBN: 9784431559740
これでわかる拡散MRI

青木, 茂樹, 阿部, 修, 増谷, 佳孝, 高原, 太郎

学研メディカル秀潤社　2013/09

ISBN: 9784780908749
医用画像工学ハンドブック

医用画像工学ハンドブック編集委員会, 日本医用画像工学会, 尾川, 浩一

日本医用画像工学会　2012/09

ISBN: 9784990666705
Machine learning in computer-aided diagnosis : medical imaging intelligence and analysis

Suzuki, Kenji

Medical Information Science Reference　2012

ISBN: 9781466600591
新版これでわかる拡散MRI

青木, 茂樹, 阿部, 修, 増谷, 佳孝

学研メディカル秀潤社　2005/10/01

ISBN: 4879622931
これでわかる拡散MRI

青木, 茂樹, 阿部, 修

秀潤社　2002/09/01

ISBN: 4879622559
外科手術のためのNIH Image

増谷, 佳孝ほか

中山書店　1996/04/01

ISBN: 4521008917

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Industrial Property Rights 9

構造推定装置、構造推定方法、および、プログラム

鈴木宗村, 増谷佳孝, 阿原一志, 植田琢也

特許第6571784号

Property Type: Patent
線維描出方法および線維描出装置

増谷佳孝, 阿部修, 青木茂樹, 椛沢宏之

特許第4823257号

Property Type: Patent
線維描出方法および線維描出装置

増谷佳孝, 阿部修, 青木茂樹, 椛沢宏之

特許第4248822号

Property Type: Patent
構造推定装置、構造推定方法、および、プログラム

鈴木宗村, 増谷佳孝, 阿原一志, 植田琢也

Property Type: Patent
コンピュータ支援の3次元病変検出方法

吉田広行, ダチマン、アブラハム, ナッピ、ジャンヌ, マセニーネイ、ピーター, ルビン、デイビッド, 増谷佳孝, ラン、リ

Property Type: Patent
法線を算出するための装置、方法およびプログラム

増谷佳孝

Property Type: Patent
線維描出方法および線維描出装置

増谷佳孝, 阿部修, 青木茂樹, 椛沢宏之

Property Type: Patent
線維描出方法および線維描出装置

増谷佳孝, 阿部修, 青木茂樹, 椛沢宏之

Property Type: Patent
線維描出方法および線維描出装置

増谷佳孝, 阿部修, 青木茂樹, 椛沢宏之

Property Type: Patent

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Research Projects 25

CTEPHを対象とした呼吸・循環の包括的評価を行う非造影one-stop shop MRIの開発

大田英揮, 矢尾板信裕, 増谷佳孝, 佐藤大樹, 一関雄輝

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2024/04/01 - 2028/03/31
Research on synthetic X-Q space learning for inference of quantitative features of biological tissues by diffusion MRI

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Hiroshima City University

2021/04/01 - 2024/03/31
Evaluation of glymphatic system in the human brain using diffusion MR images and application to Alzheimer's disease.

Taoka Toshiaki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Nagoya University

2017/04/01 - 2020/03/31

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In the current study, we hypothesized that diffusivity limited to the direction of perivascular space correlates with activity of the Glymphatic system. We developed a method called "diffusion tensor image analysis along the perivascular space (DTI-ALPS)" as a method to evaluate the movement of water molecules in deep white matter from diffusion tensor images. In this method, the diffusivity in the perivascular space in the white matter outside the lateral ventricle was evaluated using the ratio to the diffusivity in the orthogonal direction(ALPS index). In the evaluation of Alzheimer's disease cases, the ALPS index was significantly inversely correlated with the MMSE score. This suggests that the ALPS index may be an index that reflects the function of the Glymphatic system.
Creation of an international joint research base based on Multidisciplinary computational anatomy

Hashizume Makoto

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Institution: Kyushu University

2015/11/06 - 2019/03/31

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Under the established Steering Committee, four main groups for international activities were formed and the supports for international activities were provided. Based on this, we constructed an international network of international collaboration multidisciplinary computational anatomy, and promoted the training for young researchers and the international co-authorship publication to top journals in international level. In addition, the International Cooperation Committee was held, and major researchers from overseas were joined this committee as committee members. We have promoted international activities in cooperation with the searchers in China, Korea, the United States, the United Kingdom, Canada, Switzerland, and many other overseas facilities.
Mathematical Foundations of Multidisciplinary Computational Anatomy

Hontani Hidekata

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Institution: Nagoya Institute of Technology

2014/07/10 - 2019/03/31

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We would like to construct statistical models that help to understand human body by using medical images of many patients from variety of modalities. For this purpose, we studied the following topics and made results: (1) development of new imaging principle for the magnetic resonance(MR) and improvement of existing diffusion MR imaging methods, (2)mathematical foundation for measuring distances among images and registration methods of medical images that have variety of spatial resolutions and that are captured at different times, (3) methods that map organ regions based both on the shapes and the textures on the surfaces, (4) applications of high-order graph cut and deep neural networks for medical image analysis, and (5) information geometry for mathematical foundation, which helps to analyze the characteristics of statistical models constructed from small number of training data.
Multidisciplinary computational anatomy and its application to highly intelligent diagnosis and therapy

HASHIZUME MAKOTO

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Institution: Kyushu University

2014/07/10 - 2019/03/31

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The all groups were managed and operated by the coordination committee, and each WG in the coordination committee supported the organic cooperation of each group. The DB support WG has expanded the database obtained from the clinical planned research groups. The Academic Development Support WG created publication lists, the Fusion Support WG worked to translate the related materials into English, the External Affairs WG published the results on the web, and published the Newsletter. The Human Resources Development WG invited prominent researchers to hold a seminar. The Clinical Support WG has integrated and maintained the cooperative relationship of each group.
Creation of New Diagnostic Information based on multi-scale inference of bio-structures by using diffusion MRI

Masutani Yoshitaka, AOKI Shigeki, HORI Masaaki, Suzuki Yuichi, INO Kenji, NOMURA Yukihiro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Hiroshima City University

2014/04/01 - 2017/03/31

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In this project, several topics regarding diffusion MRI have been studied including inference of axon diameter or diffusional kurtosis along the radial orientation of fibers as local information of brain white matter fiber tracts, that is global information. Based on a novel approach of Q-space interpolation and reconstruction by using radial basis functions, methodology for extraction of multi-scale information (from global tract structure to local information such as axon diameter) was achieved. It did not reach to creation of completely new diagnostic information, but several successful results in this project implied that extension of this study would develop to such contribution to clinical information processing.
Development of four-dimensional CT acquisition and tumor detection system during volumetric modulated arc therapy.

NAKAGAWA Keiichi, DEMACHI Kazuyuki, MASUTANI Yoshitaka, SAKUMI Akira, HAGA Akihiro, NISHIO Teiji, SHIRAISHI Kenshiro, YAMASHITA Hideomi, IGAKI Hiroshi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: The University of Tokyo

2011/04/01 - 2014/03/31

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In this study, we have developed in-treatment kilo-voltage four-dimensional cone-beam CT (in-treatment kV 4D CBCT) acquisition during volumetric modulated arc therapy (VMAT) by use of the image-based phase recognition technique of projection images. With the in-treatment kV 4D CBCT, the respiratory motion of lung tumors has been quantitatively evaluated for the first time, and the margin applied in treatment planning has been retrospectively reanalyzed. In addition, the CBCT reconstruction using the portal images of VMAT beam and its four dimensional version (4D VMAT CBCT) have been developed. With the 4D VMAT CBCT, the tumor location and movement were visually observed. Combining 4D VMAT CBCT with in-treatment kV 4D CBCT, it is expected that the appropriate margin setting and the reduction of the extra-radiation dose for normal tissue are achieved.
Mathematical Foundations of Computational Anatomy

MASUTANI Yoshitaka, HONTANI Hidekata, IMIYA Atsushi, MATSUZOE Hiroshi, HAYASHI Naoto, OHTOMO Kuni

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Institution: The University of Tokyo

2009/07/23 - 2014/03/31

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For the goal of the project; robust computational understanding of clinical images, our researches covered mathematical methods for representation of the "Computational Anatomy Model" which statistically describes individual variations of the organ shapes, and clinical image understanding methods by using the model. The model was constructed as a set of structured points, that is, point distribution model with anatomical features. By using the clinical CT images in our database, various researches from mathematical foundation to clinical application have been performed. The studies covered (1) anatomical landmark detection initiating clinical image understanding, (2) robust image segmentation by a point distribution model with local appearance and with sparse representation, (3) spatio-temporal shape average definition by variational method, and (4) introducing deformed exponential families for treating statistical outliers such as anatomical abnormalities.
Computational Anatomy for Computer-aided Diagnosis and Therapy : Frontiers of Medical Image Sciences

KOBATAKE Hidefumi, MASUTANI Yoshitaka, SATO Yoshinobu, FUJITA Hiroshi, NIKI Noboru, MORI Kensaku, SHIMIZU Akinobu, KIDO Shoji, HASHIZUME Makoto, MEKADA Yoshito, IMIYA Atsushi, SUZUKI Naoki, NAWANO Shigeru, UENO Junji

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Institution: Tokyo University of Agriculture and Technology

2009/07/23 - 2014/03/31
Automated shape analysis of cerebral vessels from MR angiography images as a biomarker of atherosclerosis

MASUMOTO Tomohiko, MASUTANI Yoshitaka

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: University of Tsukuba

2010 - 2012

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The aim of this study is to develop a biomarker of atherosclerosis by computer-assisted shape analysis of cerebral arteries from MRA data.First, we analyzed pilot data of 10 cases using multiscale morphological approach. We defined a feature value that caused a significant difference between a control group and an atherosclerosis group, as “shape regularity index of vessel (SRIV)”.Second, 51 cases were selected as a validation data set and divided into three groups by visual evaluation of vessel wall (Grade 0: no irregularity, Grade 1: mild irregularity, Grade 2: severe irregularity). A significant difference was found in SRIV value between Grade 0 and 1, and between Grade 1 and 2.We concluded that SRIV value had a correlation with vessel wall irregularity evaluated visually, and this value would be an objective biomarker of atherosclerosis.
Development of Diagnostic and Therapeutic Support System based on Novel Brain Atlas with Morphological, Functional and Pathological Information

MASUTANI Yoshitaka, HAYASHI Naoto, SUZUKI Yuichi, ABE Osamu, KAMADA Kyousuke

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: The University of Tokyo

2009 - 2011

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In this study, we aimed at construction of an "integrated brain atlas" as a standard brain map consisting of morphological, functional and pathological information of brain, and its application to diagnosis and therapy. We developed various techniques and systems for MR imaging, image processing and display for diagnostic support, surgical navigation. As a result, we achieved an integrate atlas of multivariate map including biological diffusional information, and completed systems for diagnostic and therapeutic aid, and performed preliminary experiments.
Volumetric modulated arc therapy (VMAT) and in-VMAT cone beam CT

NAKAGAWA Keiichi, TERAHARA Atsuro, YAMASHITA Hideomi, SHIRAISHI Kenshiro, IGAKI Hiroshi, MASUTANI Yoshitaka, NISHIO Teiji, GOMI Tsutomu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: The University of Tokyo

2008 - 2010

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The authors established volumetric modulated arc therapy (VMAT) which is combined avoidance technique and dose-rate modulation. Three-dimensional tumor position during M was developed in-VMAT kilovoltage (kV) cone-beam CT (CBCT) to ensure treatment quality. Treatment time required for VMAT was about 2 min while 5~10min in conventional IMRT. The mean and standard deviation of displacements at the time of pre-treatment against the intreatment position of all the six days for the patient were 0.1±0.2mm, -0.3±0.4mm, -0.4±0.6mm in lateral, vertical, and longitudinal directions.
脳機能画像と皮質電位時間-周波数解析による言語・記憶機能検出と空間-時間変動分析

鎌田恭輔, 増谷佳孝, 竹内文也

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 特定領域研究

Institution: 東京大学

2008 - 2009

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言語・記憶機能マッピングの脳機能画像と実際のECoG計測結果、電気刺激による脳機能マッピングについて、患者の神経脱落症状に結びついた課題を確立した。認知ECoGの時間-周波数解析により、特定周波数帯域の同期(β、γ帯域等)、脱同期(β帯域等)に関する検討を行った。同時に加算波形、周波数変化に関する統計解析法も検討した。さらに有意な電位変化について相関係数、t検定などを応用していった。また、海馬近傍部の活動に着目して記憶機能との関連性を検討した。naming課題に用いた図形を用いて、記憶課題によるECoG計測を行い、同じ刺激を用いたnamingと記憶課題時の海馬活動の違いを解析した。過去にP300の起源に海馬が関係しているとの報告があるため、音刺激、視覚刺激によるP300の海馬近傍部ECoGを解析してみた。その結果刺激呈示後600msec付近で海馬近傍に統計学的に優位な陰性波を認めた。また、覚醒下手術においては切除領域における白質刺激部位とその刺激強度、tractography上の弓状線維との関係も検討した。弓状束tractographyを刺激したときには物品名称の障害が出現した。刺激部位が弓状束tractographyの2mm以内に近接したときには常に同様の症状が出現した。MEG、fMRI,皮質電気刺激、認知ECoGにより検出されたヒト高次脳機能とtractographyにより白質線維連絡を融合することで、ヒト脳機能ネットワークを解明することができる可能性を示唆できた。将来的には各活動部位のつながりを確認するために、活動部位1ヶ所を0.2msec3-5mAの電気刺激することにより皮質-皮質誘発電位(CCEP)を関連脳部位から導出する。
Visualization of brain network of language/memory-related functionsby electrical stimulation and electroencephalogram

KAMADA Kyousuke, MASUTANI Yoshitaka, TANEUCHI Fumiya

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: The University of Tokyo

2007 - 2008
Development of Fusional System for Diagnostic-Therapeutic Support in Brain-neuro Area

MASUTANI Yoshitaka, AOKI Shigeki, KAMADA Kyousuke, AOKI Shigeki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: The University of Tokyo

2007 - 2008
Mapping of the white matter tracts using diffusion tensor MRI : location of the pyramidal tract using normalization

AOKI Shigeki, ABE Osamu, MASUTANI Yoshitaka, KASAI Kiyoto

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: The University of Tokyo

2006 - 2008
An integrated imaging approach to tumor model animals using bioluminescence imaging and magnetic resonance imaging

INOUE Yusuke, TOJO Arinobu, YOSHIKAWA Kohki, MASUTANI Yoshitaka, TOJO Arinobu, YOSHIKAWA Kohki, MASUTANI Yoshitaka

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: The University of Tokyo

2006 - 2008
言語・記憶機能の画像化と脳皮質電位計測、電気刺激による検証

鎌田恭輔, 増谷佳孝, 竹内文也

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 特定領域研究

Institution: 東京大学

2006 - 2007

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【目的】脳磁図(MEG),機能MRI(fMRI)をはじめとする脳機能画像の飛躍的な進歩により、言語優位半球の同定が可能になった。しかし、機能画像の活動領域局在に関する検証は十分に行われていない。本検討では言語課題による機能画像と、慢性硬膜下電極による誘発皮質電位(ECoG)による脳機能マッピングとの比較・検討を行った。【方法】難治性てんかん患者26症例にてんかん焦点同定のために慢性硬膜下電極を留置した。全例Wada testにより言語優位半球を同定した。そのなかで言語機能が左、または右に強く偏位し、かつWAIS-Rによる平均IQが90以上の8症例ついて解析した。文字読み、記憶、語想起、P300課題をおこない、認知ECoG取得した。ECoGは加算平均解析を行った。【結果】機能MRIでは、主に片側の中、または下前頭回周辺に活動を認めた。脳磁図では優位半球側内紡錘回と、上側頭回後部にダイポールの集積を認めた。文字読み課題による加算ECoGは、全例で紡錘回後部に200-300msecの潜時で急峻な電位変化をみとめた。次に優位半球上下-中前頭回に300-400msecに活動、それに引き続いて上側頭回〜縁上回に400msec以降の遅い認知反応(77%)を検出した。刺激後600msec以降に再び前頭葉と側頭葉は同時に有意な電位変化を認めた。これらの活動部位を皮質電気刺激することにより言語関連機能障害を誘発した。電気刺激とECoG変化によるマッピングの結果が高く一致していた。一方語想起fMRIでは、これらのマッピング結果よりも広く前頭葉に活動を認めた。文字読みMEGでは側頭葉底部、上側頭回後部に活動を認め、電気刺激とECoG変化によるマッピング結果とほぼ一致していた。今後は前頭葉、側頭葉内の活動部位の詳細な検討と、ECoG活動を構成している周波数成分の解析を行っていく予定である。
Development of Microsurgery Robotic System and Digitalization of microsurgical tehnique

MORITA Akio, MITSUISHI Mamoru, ONOGI Yuzaou, SUGITA Naohiko, MASUTANI Yoshitaka

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: The University of Tokyo

2005 - 2007

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In this research, we developed and advanced microsurgical Robotic System and produced scientific analysis method of Microsurgical Skill by digitalized microsurgical techniques. First we created new offset type robotic manipulator, which would not interfere with visual system such as microscope or endoscope. Then this system was equipped with intermediate working part, which will make our system sterilizable. After sterilization of the system and continuous 2hour manipulation, the tip of the manipulator was proved to be sterile. Also, we created new master manipulator system, which involves Ginbaru System, and with this master manipulator robot, surgeon could control the robot by moving fingers and wrist. This is similar to the condition of microsurgical procedures. After creating such advanced robotic system, we now proceeding with various experiments. Using such system, surgical procedures were analyzed in scientific manner. First robotic procedure was analyzed. Ideal reduction rate for robotic surgery was believed to be around 20:1 or 40:1 in laparoscopic procedures, but in the field of microsurgery, this was 5:1 to 10:1. The difference is possibly due to difference of scale of routine surgery. Microsurgeons are not used to do massive movements in performing delicate procedures. Second, learning curve of micro procedures by robotic system by the beginners was assessed. Micro artificial vessel was sutured together using our robotic system by three engineer students, who never perform microsurgery. Their procedure time stabilized after several practice within one hour, and procedure was accurate. This proved robotic system allows rapid leering of microsurgical procedures. Next step was digitalization of microsurgical skills. The computer control signals were stored in 100Hz batches during robotic anastomosis of the micro vessels. By this method, we could display X, Y, Z movement distance in time log, velocity of the hand, accelerations, angle acceleration during each procedure. By this method we could analyze coordination of each hand, speed and acceleration during specific procedures and range of motion. Using this technique, we can analyze surgical technique in scientific way By storing master surgeons procedures and reproducing it in the force feedback master system, surgeons will be able to learn master surgeons hand speed and L-R coordination. Putting strain gauge on the forceps, we analyzed strength used during vessel anastomosis. Senior surgeon could control left hand very smoothly and strength in l was almost equal to R hand. But by the less experienced surgeons, strength on L was very high and continuously applied. This trend could be improved by practice. The strength applied to the tip of forceps was around 2N at most by experienced senior surgeons. This research proved microsurgical robotic sys tern improve surgical procedure in the future, and involving such medico- engineering method in analyzing microsurgical skill, will improved our future surgical education.
Target-tracking system in the stereotactic radiation therapy for body tumors

NAKAGAWA Keiichi, UESAKA Mitsuru, AOKI Yukimasa, TAGO Masao, MASUTANI Yoshitaka, ISHIKAWA Masatoshi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: The University of Tokyo

2005 - 2007

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(1) Four-dimensional lung cancer imaging has been successfully performed by using a multi-detector CT (2) Real-time fluoroscopic tumor imaging has been achieved by using a flat panel detector for MV x-ray. (3) A kilovolt x-ray CT imaging technique has been developed by using radiotherapy machine. (4) A respiratory curve has been derived from the patient diaphragm position obtained by kilovoltage x-ray imaging. (5) A technique for in-treatment kV cone beam CT imaging has been established. (6) A method for measuring patient set-up errors has been developed for stereotactic radiotherapy immediately before treatment, during treatment, and immediately after treatment. Clinical study has also been launched. (7) A real-time tumor tracking system has been developed by detecting the tumor position estimated from the patient diaphragm position using in-treatment kV x-ray imaging. (8) As for clinical application of large bore CT for radiotherapy. We have applied a 90 cm bore CT to radiotherapy practice. (9) A tumor tracking algorithm has been developed by increasing MW maximum leaf speed. (10) Intensity modulated arc therapy has been achieved by successfully controlling dose rate and gantry speed. (11) We have addressed a problem and proposed a solution to apply previously developed x-band linac to radiotherapy practice. (12) Real-time tumor tracking using robot arm-mounted linac has been studied from a robot engineering view. (13) We have designed a next-generation tracking system by combining a linac with a robot arm and a CT imager. (14) The target and risk organs have been localized immediately before treatment, during treatment and immediately after treatment by using built-in CT imaging unit. (15) We have discovered that commercially available drug serves as a radiosensitizer, and have revealed its radiobiological mechanism. (16) Total assessment and clinical application We have obtained significant treatment outcome by applying our results to clinical practice.
Validation of the motor/language functional localizations by functional neuroimaging and tractographyby-integrated neuronavigation

KAMADA Kyousuke, MASUTANI Yoshitaka, TAKEUCHI Fumiya

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: The University of Tokyo

2005 - 2006

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It is known that functional magnetic resonance imaging(fMRI) and magnetoencephalography(MEG) are sensitive to the frontal and temporal language function, respectively.. We, therefore, established combined utilization of fMRI and MEG to make reliable identification of the global language dominance in the pathological brain conditions. We investigated 117 patients with brain lesions whose language dominance was successfully confirmed by the Wada test. All patients were asked to generate verbs related to acoustically presented nouns(verb generation) for fMRI and to read 3-letter words for fMRI and MEG. fMRI typically showed prominent activations in the inferior and middle frontal gyri, whereas calculated dipoles on MEG typically clustered in the superior temporal region and the fusiform gyrus of the dominant hemisphere. A total of 87 patients were further analyzed using useful data from both the combined method and the Wada test. Remarkably, in the 87 patients, we observed a 100% match of the combination method results on the language dominance with the Wada test results, including the two cases that showed expressive and receptive language areas dissociated into bilateral hemispheres. In order to confirm localization of language-fMRI and -MEG, we used electrical cortical stimulation(ECS) with subdural electrodes in 13 patients with intractable epilepsy. ECS to the inferior frontal love including fMRI activation demonstrated speech arrest, while ECS to fusiform gyrus and superior temporal region caused dyslexia. The results demonstrate that this non-invasive and repeatable method is not only highly reliable in determining the language dominance, but can also locate the expressive and receptive language areas separately. The method may be a potent alternative to invasive procedures of the Wada test, and useful in treating patients with brain lesions.
HARD-MR画像および形態・機能の情報統合に基づく高精度脳白質神経束モデリング

増谷佳孝, 青木茂樹, 阿部修

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 特定領域研究

Institution: 東京大学

2005 - 2006

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高方向分解能を有するHARD-MRIのデータに基づき,様々な処理手法の開発,および臨床応用に関する研究を行った.具体的には,以下の3項目を中心に研究を行った. 【線維交叉の前駆知識に基づく新しい線維モデリング手法の開発】上縦束と錐体路の交叉関係を前駆知識とする新しい手法を提案し,有効性を示した.モデリング対象に沿って関心領域を設定する従来の方法は自由度が高く,どのような線維も描出可能となる反面,領域の設定数により操作が煩雑になり,限られたテンソルからの再構成テンソル場の使用による過度の平滑化効果を生じる場合があった.新手法では,テンソル場補間を交叉部である上縦束に限定することで上記の問題が抑制されており,臨床データの処理において実用性が高まった. 【テンソル場補間によるモデリングとHARD-MRIデータに基づくテンソル分離に関する検討】我々のモデリング手法とHARD-MRIのデータの併用による線維交叉部でのテンソル分離について,臨床で撮影可能な30方向程度で良好な結果が得られることが明らかになった.これにより,健常者の詳細データの蓄積のみならず,患者データによる病態評価,異常検出にも応用が可能となった. 【リーマン計量によるテンソル補間時の膨張効果低減に関する検討】テンソル場補間に関する基礎的検討では,対数ユークリッド法を用いることで,僅かながら膨張効果の低減があることが示唆された.また,膨張効果は拡散テンソルの第1固有値の低下,および第2,第3固有値の上昇という2つの要因によるものであるが,詳細な実験結果により,対数ユークリッド法の優位性は,後者の抑制に優れている点が明らかとなった.但し,現時点では,膨張効果の解消につながる根本的な解決には至っていないため,今後,新たな補間手法の開発が必要である. これら技術開発の他,診断・治療を問わず,様々な臨床応用を行い,論文発表を行った.
形態情報と機能情報の統合によるコンピュータ支援診断のための脳白質神経束モデリング

増谷佳孝, 青木茂樹, 阿部修

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 特定領域研究

Institution: 東京大学

2004 - 2004

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形態情報と機能情報を統合した脳白質神経束モデリング手法の開発および検証を目的として、当初の計画に従い、以下の3つの側面から研究を進めてきた。 (1)線維交叉を考慮した脳白室線維束の形態モデリング交叉部における線維追跡誤差の問題に対し、線維交叉部を除いた領域の拡散テンソルの主方向より形成されるベクトル場を動径基底関数にて補間し、交叉部における走行方向を推定することにより、交叉部を通過する線維の良好な描出が可能となる手法を開発した。この成果は、国際磁気共鳴医学会にて発表を行い、日本医用画像工学会誌にて掲載済みである。 (2)抽出された線維束の接続性評価のための数値指標の決定拡散テンソルの限られた情報から、全く新しい数値指標を得ることは困難であったが、一般的に使用されている異方性指標であるFA(Fractional Anisotropy)値が、診断上、重要かつ有効な指標であることを示した。具体的には、統合失調症患者群と健常者群の間で、特定の線維束構造においてFA値が有意に低下することを確認した。この成果は、日本磁気共鳴医学会誌に投稿中である。 (3)MR-DTIデータの収集健常者、患者データともに新規のMR-DTIデータ撮影、および過去に撮影された患者のMR-DTIデータの選定を行い、100例程度のデータが保存されている。この他、形態モデリングの結果を、脳外科手術や放射線治療に応用できることを示し、共同研究者である脳外科医とともに論文をJournal of Neurosurgery誌に投稿しており、2005年4月号に掲載予定である。また、診断の基礎となる、特定構造の可視化や解析に関する論文も投稿し、採録されている。
Basic study to establish the method to evaluate surface vascular lesions by utilization of optical coherence tomography.

HAYASHI Naoto, AKI Shigeki, MASUTANI Yoshitaka, MASUMOTO Tomohiko

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: The University of Tokyo

2002 - 2004

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This study was begun without means of obtaining the optic coherence tomography (OCT) system. The main supplier of OCT systems went under acquisition by another company. And at the same time, the OCT system was undergoing application for approval, which also prevented us from obtaining the OCT system. Though there was a major delay in the initiation of our research, we have managed to achieve the following results with the help from a research group in University of Osaka. We aimed to evaluate arteriosclerotic changes and diabetic changes of the surface arteries by a non-invasive method using OCT system. While the standard spatial resolution of OCT systems may be 10-20 micrometers, the maximum scanning distance is only one millimeter, so we selected the dorsal digital arteries as our measurement target since they are situated aright under the skin and easy to position under the OCT system. The experiment showed that the maximum scanning distance was insufficient even for the digital arteries and the localization of the arteries in the field of view was very difficult Consequently the depiction of the digital arteries was so poor that the optimization of the measurement process was not possible. To improve the scanning distance, we are now developing a new OCT system using 1.53-micrometer wave length laser and in-focus coherence gate detection optic system with the aid of a high-frequency ultrasound probe to localize the target in the field of view. And to minimize the effect of motion artifacts, we have tested a high-speed OCT system with an optic fiber PZT modulator in the low frequency inferometer. Our previous research have been mainly in the development of the hardware to measure surface arteries. We are now entering a new phase of our research to develop the software to apply the OCT system to clinical uses.

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