研究者詳細

顔写真

オノダ　ヨシト
小野田　祥人
Yoshito Onoda
所属
病院　外科　整形外科
職名
助教
学位

  • 医学博士 （東北大学）

論文 59

  1. Extent of intramedullary short tau inversion recovery signal change predicts traumatic cervical spinal cord injury outcomes in surgically treated older adults: a multicenter study in Japan. 国際誌

    Takashi Takizawa, Shota Ikegami, Masashi Uehara, Hiroki Oba, Noriaki Yokogawa, Takeshi Sasagawa, Hiroaki Nakashima, Naoki Segi, Sadayuki Ito, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Kota Watanabe, Satoshi Nori, Kazuki Takeda, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Hidetomi Terai, Koji Tamai, Akiyoshi Kuroda, Gen Inoue, Takashi Yurube, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Shiro Imagama, Satoshi Kato

    Asian spine journal　2026年7月9日

    DOI： 10.31616/asj.2025.0748 　

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    STUDY DESIGN: A retrospective multicenter study. PURPOSE: To determine whether the extent of intramedullary hyperintensity on initial fat-suppressed short tau inversion recovery (STIR) magnetic resonance imaging (MRI) predicts neurological outcomes in elderly patients with traumatic cervical spinal cord injury (CSCI) undergoing surgery. OVERVIEW OF LITERATURE: Prognostic stratification in elderly patients with CSCI remains challenging because neurological recovery varies widely. Studies focusing exclusively on surgical populations evaluating imaging predictors-particularly STIR signal changes-are limited. METHODS: We retrospectively reviewed patients aged ≥65 years with traumatic CSCI treated at 33 institutions. All patients underwent surgery. Based on initial STIR MRI findings, patients were categorized as H0 (no intramedullary signal change), H1 (single-level change), or H2 (multilevel change). Neurological status was evaluated using the American Spinal Injury Association Impairment Scale (AIS) at injury and final follow-up. A good outcome was defined as AIS grade D/E at follow-up without deterioration or improvement of ≥1 AIS grade. A poor outcome was defined as AIS grade C or worse without improvement. After excluding cases with missing data, inverse probability of treatment weighting (IPTW) was applied for multivariate adjustment in 622 patients (H0=132, H1=350, H2=140). RESULTS: Good outcomes were observed in 92% of H0, 80% of H1, and 68% of H2. Compared with H0, both H1 and H2 were independently associated with higher odds of poor outcomes (IPTW-adjusted odds ratio: 2.4 for H1 vs. H0 and 3.2 for H2 vs. H0). CONCLUSIONS: In surgically treated elderly patients with traumatic CSCI, the presence of intramedullary STIR hyperintensity at presentation-particularly across multiple levels-was strongly associated with poorer neurological recovery. The extent of STIR signal change may aid initial risk stratification and clinical decision-making.

  2. Clinical Features and Surgical Management for Spinal Plexiform Schwannomas: Three Case Series and Literature Review.

    Taishi Murakami, Takahiro Onoki, Ko Hashimoto, Yoshito Onoda, Kohei Takahashi, Kenichiro Yahata, Keisuke Ishikawa, Yuki Sato, Junya Kusakabe, Tomonori Kawaharada, Toshimi Aizawa

    The Tohoku journal of experimental medicine　2026年4月9日

    DOI： 10.1620/tjem.2026.J026 　

  3. Impact of delayed diagnosis on surgical management and neurological outcomes in elderly patients with cervical spinal cord injury without radiographic evidence of trauma: a multicenter registry study. 国際誌

    Tomohiro Yamada, Yu Yamato, Tomohiko Hasegawa, Yukihiro Matsuyama, Noriaki Yokogawa, Takeshi Sasagawa, Hiroaki Nakashima, Naoki Segi, Sadayuki Ito, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Kota Watanabe, Satoshi Nori, Kazuki Takeda, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Hidetomi Terai, Koji Tamai, Akiyoshi Kuroda, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Shiro Imagama, Satoshi Kato

    Spinal cord　64　(4)　324-330　2026年4月

    DOI： 10.1038/s41393-026-01185-2 　

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    STUDY DESIGN: Multicenter retrospective cohort study. OBJECTIVES: To investigate the impact of delayed diagnosis on treatment decisions and neurological outcomes in elderly patients with cervical spinal cord injury (CSCI) without radiographic evidence of trauma (SCIWORET). SETTING: Nationwide multicenter registry of the Japan Association of Spine Surgeons with Ambition (JASA). METHODS: Data from patients aged ≥65 years with traumatic cervical SCIWORET treated between 2010 and 2020 were reviewed. Delayed diagnosis was defined as a diagnosis of CSCI made more than 24 hours after injury, either because of (1) physician delay (missed diagnosis despite presentation) or (2) patient delay (injury-to-hospital arrival > 24 hours). Clinical characteristics, radiological findings, treatment strategies, and neurological outcomes (American Spinal Injury Association Impairment Scale, AIS) were compared between early and delayed diagnosis groups. RESULTS: Among 613 elderly patients with SCIWORET, 81 (12.8%) experienced delayed diagnosis. These patients were significantly older (p = 0.048), more frequently dependent for ambulation (p < 0.001), and commonly injured by ground-level falls (p < 0.01). Initial AIS grades and radiological findings were comparable between groups. However, patients with delayed diagnosis underwent more frequent surgical intervention at admission (p < 0.001) and more frequent conversion from conservative to surgical management due to neurological deterioration (p < 0.001). Final AIS grades did not differ significantly between groups. CONCLUSIONS: Delayed diagnosis of SCIWORET in elderly patients is associated with increased surgical intervention without improved neurological recovery. Early recognition and timely MRI assessment may help reduce potentially avoidable surgery.

  4. β2-microglobulin amyloid deposition and the RAGE-related inflammation pathway in ligamentum flavum thickening among patients undergoing hemodialysis: a comparative cross-sectional study from Japan. 国際誌

    Keisuke Ishikawa, Yutaka Yabe, Yoshito Onoda, Takahiro Onoki, Kohei Takahashi, Ko Hashimoto, Toshimi Aizawa

    Asian spine journal　2026年3月17日

    DOI： 10.31616/asj.2025.0595 　

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    STUDY DESIGN: A comparative cross-sectional study using histological, biochemical, and molecular analyses of ligamentum flavum (LF). PURPOSE: To investigate whether LF hypertrophy in hemodialysis (HD) patients is associated with β2-microglobulin (B2M) amyloid and advanced glycation end-product (AGE) deposition, along with the receptor for AGE (RAGE)-related inflammatory activation. OVERVIEW OF LITERATURE: Lumbar spinal canal stenosis (LSCS) is common in HD patients. Although B2M amyloid is a hallmark of dialysisrelated amyloidosis, the role of the AGE-RAGE axis in LF pathology remains unclear. METHODS: LF tissues from 33 patients with LSCS (HD, n=16; non-HD, n=17) were analyzed. Amyloid deposition was evaluated using direct fast scarlet (DFS) staining and B2M immunohistochemistry. Pentosidine and carboxymethyl-lysine (CML) levels were quantified by high-performance liquid chromatography in subsets (n=6 per group). Expression of RAGE-related inflammatory genes was measured using quantitative reverse transcription-polymerase chain reaction. Comparisons were made between the HD and non-HD groups, paired comparisons of DFS-stained areas on the dorsal and ventral sides of LF were performed within the HD group. RESULTS: B2M amyloid deposition was observed exclusively in LF of HD group and predoninated dorsally (29.7%±8.6% vs. 11.9%±6.9%, p=0.001). Pentosidine levels were significantly higher in HD group than in non-HD group (28.5±10.6 μg/g vs. 16.1±4.2 μg/g, p=0.009), whereas CML levels didn't differ. On the dorsal side of LF, all examined RAGE-related inflammatory genes except toll-like receptor 4 was significantly upregulated in HD group; ventral expression showed no group differences. Immunohistochemical analysis demonstrated localized expression of RAGE, high-mobility group box 1, and nuclear factor-kappa B surrounding amyloid deposits. CONCLUSIONS: LF in HD patients exhibits B2M amyloid and AGE accumulation with upregulation of RAGE-related inflammatory genes and proteins, especially on the dorsal side. LF hypertrophy in dialysis-related LSCS appears to represent an inflammatory-amyloid phenotype, indicating the AGE-B2M-RAGE pathway as a potential therapeutic target.

  5. A deep learning-based prediction model for prognosis of cervical spine injury: a Japanese multicenter survey. 国際誌

    Sadayuki Ito, Hiroaki Nakashima, Naoki Segi, Noriaki Yokogawa, Takeshi Sasagawa, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Kota Watanabe, Satoshi Nori, Kazuki Takeda, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Hidetomi Terai, Koji Tamai, Akiyoshi Kuroda, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Masahiro Oda, Seiji Okada, Shiro Imagama, Satoshi Kato

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society　34　(9)　3714-3723　2025年9月

    DOI： 10.1007/s00586-025-08708-0 　

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    PURPOSE: Cervical spine injuries in the elderly (defined as individuals aged 65 years and older) are increasing, often resulting from falls and minor trauma. Prognosis varies widely, influenced by multiple factors. This study aimed to develop a deep-learning-based predictive model for post-injury outcomes. METHODS: This study analyzed a nationwide dataset from the Japan Association of Spine Surgeons with Ambition, comprising 1512 elderly patients (aged 65 years and older) with cervical spine injuries from 2010 to 2020. Deep learning predictive models were constructed for residence, mobility, and the American Spinal Injury Association Impairment Scale (AIS). The model's performance was compared with that of a traditional statistical analysis. RESULTS: The deep-learning model predicted the residence and AIS outcomes with varying accuracies. The highest accuracy was observed in predicting residence one year post-injury. The model also identified that the AIS score at discharge was significantly predicted by upper extremity trauma, mobility, and elbow extension strength. The deep learning model highlighted factors, such as upper extremity trauma, that were not considered significant in the traditional statistical analysis. CONCLUSION: Our deep learning-based model offers a novel method for predicting outcomes following cervical spine injuries in the elderly population. The model is highly accurate and provides additional insights into potential prognostic factors. Such models can improve patient care and individualize future interventions.

  6. Spontaneous Dural Tear Caused by Grade-I Isthmus Spondylolisthesis: A Case Report. 国際誌

    Takahiro Onoki, Kohei Takahashi, Ko Hashimoto, Yoshito Onoda, Kenichiro Yahata, Ryo Fujita, Keisuke Ishikawa, Junya Kusakabe, Mishio Chiba, Toshimi Aizawa

    JBJS case connector　15　(3)　2025年7月1日

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    CASE: A 47-year-old woman presented with severe left-sided sciatica and urinary retention. Computed tomography myelography revealed spondylolysis of the second lumbar vertebra with cerebrospinal fluid leakage. The patient underwent surgery; the 2 cauda equina filaments that had prolapsed from the dural tube were repositioned, along with the repair of the dura mater, followed by instrumented lumbar fusion. Postoperatively, the patient's leg pain was completely relieved; however, her urinary retention persisted. CONCLUSION: Computed tomography myelography is important for the early diagnosis and detailed preoperative assessment of spontaneous dural tears, which are caused by osteophytes that form in areas of spondylosis.

  7. Is Intraoperative Blood Loss Volume in Elderly Cervical Spine Injury Surgery Greater in Patients with Ankylosis? A Multicenter Survey.

    Masashi Uehara, Shota Ikegami, Takashi Takizawa, Hiroki Oba, Noriaki Yokogawa, Takeshi Sasagawa, Hiroaki Nakashima, Naoki Segi, Sadayuki Ito, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Kota Watanabe, Satoshi Nori, Kazuki Takeda, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Hidetomi Terai, Koji Tamai, Akiyoshi Kuroda, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Shiro Imagama, Satoshi Kato

    Spine surgery and related research　8　(6)　575-582　2024年11月27日

    DOI： 10.22603/ssrr.2023-0118 　

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    INTRODUCTION: Preoperative estimations of blood loss are important when planning surgery for cervical spine injuries in older adults. The association between ankylosis and blood loss in perioperative management is of particular interest. This multicenter database review aimed to evaluate the impact of ankylosis on surgical blood loss volume in elderly patients with cervical spine injury. METHODS: The case histories of 1512 patients with cervical spine injury at among 33 institutions were reviewed. After the exclusion of patients without surgery or whose blood loss or ankylosis status was unclear, 793 participants were available for analysis. Differences in blood loss volume were compared between the Ankylosis (+) group with ankylosis at the cervical level and the Ankylosis (-) group without by the inverse probability of treatment weighting (IPTW) method using a propensity score. RESULTS: Of the 779 patients (mean age: 75.0±6.3 years) eligible for IPTW calculation, 257 (32.4%) had ankylosis at the cervical level. The mean blood loss volume was higher in Ankylosis (+) patients than in Ankylosis (-) patients (P<0.001). This difference did not reach statistical significance when weighted by background factors, with mean blood loss of 244 mL and 188 mL, respectively, after adjustment. CONCLUSIONS: This study revealed that ankylosis was significantly associated with increased blood loss volume when unadjusted by surgical time. Elderly patients with cervical spine injury accompanied by ankylosis appear predisposed to higher bleeding and severe hemorrhage, both as a result of the condition and their particular demographic characteristics.

  8. Comparative Analysis of Characteristics of Lower- and Mid-Cervical Spine Injuries in the Elderly.

    Naoki Segi, Hiroaki Nakashima, Sadayuki Ito, Jun Ouchida, Noriaki Yokogawa, Takeshi Sasagawa, Takeo Furuya, Atsushi Yunde, Toru Funayama, Fumihiko Eto, Kota Watanabe, Satoshi Nori, Shota Ikegami, Masashi Uehara, Ko Hashimoto, Yoshito Onoda, Hideaki Nakajima, Hidenori Suzuki, Yasuaki Imajo, Tomohiro Yamada, Tomohiko Hasegawa, Kenichi Kawaguchi, Yohei Haruta, Yoshinori Terashima, Ryosuke Hirota, Hitoshi Tonomura, Munehiro Sakata, Yoichi Iizuka, Hiroshi Uei, Nobuyuki Suzuki, Koji Akeda, Hiroyuki Tominaga, Shoji Seki, Yasushi Oshima, Takashi Kaito, Bungo Otsuki, Kazuo Nakanishi, Kenichiro Kakutani, Haruki Funao, Toshitaka Yoshii, Daisuke Sakai, Tetsuro Ohba, Masashi Miyazaki, Hidetomi Terai, Gen Inoue, Seiji Okada, Shiro Imagama, Satoshi Kato

    Spine surgery and related research　8　(6)　560-567　2024年11月27日

    DOI： 10.22603/ssrr.2024-0030 　

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    INTRODUCTION: Elderly patients have a higher frequency of upper cervical fractures caused by minor trauma; nevertheless, the clinical differences between mid- and lower-cervical (C6-C7) injuries are unclear. The aim of this study was to compare the epidemiology of lower- and mid-cervical injuries in the elderly. METHODS: This multicenter, retrospective study included 451 patients aged 65 years or older who had mid- or lower-cervical fractures/dislocations. Patients' demographic and treatment data were examined and compared based on mid- and lower-cervical injuries. RESULTS: There were 139 patients (31%) with lower-cervical injuries and 312 (69%) with mid-cervical injuries. High-energy trauma (60% vs. 47%, p=0.025) and dislocation (55% vs. 45%, p=0.054) were significantly experienced more often by elderly patients with lower-cervical injuries than by patients with mid-cervical injuries. Although the incidence of key muscle weakness at the C5 to T1 levels were all significantly lower in patients with lower-cervical injuries than those with mid-cervical injuries, impairments at C5 occurred in 49% of them, and at C6, in 65%. No significant differences were found in the rates of death, pneumonia, or tracheostomy requirements, and no significant differences existed in ambulation or ASIA impairment scale grade for patients after 6 months of treatment. CONCLUSIONS: Elderly patients with lower-cervical fractures/dislocations were injured by high-energy trauma significantly more often than patients with mid-cervical injuries. Furthermore, half of the patients with lower-cervical injuries had mid-cervical level neurological deficits with a relatively high rate of respiratory complications.

  9. Low Nutrition before Injury Is a Risk Factor for Dysphagia in Older Patients with Cervical Spinal Cord Injury: Based on a Multicenter Data of 707 Patients.

    Naoki Segi, Hiroaki Nakashima, Sadayuki Ito, Jun Ouchida, Noriaki Yokogawa, Takeshi Sasagawa, Toru Funayama, Fumihiko Eto, Kota Watanabe, Satoshi Nori, Takeo Furuya, Atsushi Yunde, Yoshinori Terashima, Ryosuke Hirota, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Kenichi Kawaguchi, Yohei Haruta, Ko Hashimoto, Yoshito Onoda, Kazuo Nakanishi, Kosuke Misaki, Shota Ikegami, Masashi Uehara, Hidenori Suzuki, Yasuaki Imajo, Hiroshi Uei, Hirokatsu Sawada, Hidetomi Terai, Koji Tamai, Akiyoshi Kuroda, Gen Inoue, Nobuyuki Suzuki, Kenji Kato, Koji Akeda, Norihiko Takegami, Yoichi Iizuka, Yasushi Oshima, Hitoshi Tonomura, Katsuhito Kiyasu, Haruki Funao, Toshitaka Yoshii, Masayuki Ishihara, Takashi Kaito, Shoji Seki, Kenichiro Kakutani, Hiroyuki Tominaga, Tetsuro Ohba, Daisuke Sakai, Bungo Otsuki, Masashi Miyazaki, Seiji Okada, Shiro Imagama, Satoshi Kato

    Spine surgery and related research　8　(5)　473-479　2024年9月27日

    DOI： 10.22603/ssrr.2023-0227 　

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    INTRODUCTION: For older adults, dysphagia is a serious problem that can occur after spinal cord injury (SCI), but its risk factors are unclear. This study aimed to identify risk factors for dysphagia in elderly patients (≥65 years) with cervical SCI. METHODS: This multicenter study included 707 patients with cervical SCI (mean age 75.3 years). Univariate and multivariate analyses were conducted for patient characteristics and geriatric nutritional risk index (GNRI). RESULTS: Dysphagia occurred in 69 patients (9.8%). The significant factors were as follows: male sex (odds ratio [OR] 3.43), GNRI <92 (1.83), dementia (2.94), fracture (3.40), complete paralysis (3.61), anterior surgery (3.74), and tracheostomy (17.06). Age was not identified as a risk factor. CONCLUSIONS: Low GNRI before injury was one of the independent risk factors for dysphagia after geriatric cervical SCI. GNRI represents the comprehensive nutritional status of the elderly and reflects feeding function and its recovery capacity.

  10. 非定型大腿骨転子下骨折に対し外反骨切りを併用し髄内釘固定を行った1例

    石津 敦玄, 菅谷 岳広, 小暮 敦史, 小野田 祥人, 相澤 俊峰

    東北整形災害外科学会雑誌　67　(1)　95-98　2024年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN：1348-8694

  11. Neurological recovery rate and predictive factors of incomplete AIS grade C spinal cord injury in the older aged population. 国際誌

    Koji Tamai, Hidetomi Terai, Hiroaki Nakamura, Noriaki Yokogawa, Takeshi Sasagawa, Hiroaki Nakashima, Naoki Segi, Sadayuki Ito, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Kota Watanabe, Junichi Yamane, Kazuki Takeda, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Akiyoshi Kuroda, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Shiro Imagama, Satoshi Kato

    Spinal cord　62　(4)　149-155　2024年4月

    DOI： 10.1038/s41393-024-00963-0 　

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    STUDY DESIGN: Retrospective cohort study. OBJECTIVES: To define the prognosis and predictive factors for neurological improvement in older patients with incomplete spinal cord injury (SCI) of American Spinal Injury Association Impairment Scale grade C (AIS-C). SETTINGS: Multi-institutions in Japan. METHODS: We included patients aged ≥65 years with traumatic SCI of AIS-C who were treated conservatively or surgically with >3 follow-up months. To identify factors related to neurological improvement, patients were divided into three groups according to their neurological status at the final follow-up, with univariate among-group comparisons of demographics, radiographic, and therapeutic factors. Significant variables were included in the multivariate logistic regression analysis. RESULTS: Overall, 296 older patients with SCI of AIS-C on admission were identified (average age: 75.2 years, average follow-up: 18.7 months). Among them, 190 (64.2%) patients improved to AIS-D and 21 (7.1%) patients improved to AIS-E at final follow-up. There were significant among-group differences in age (p = 0.026), body mass index (p = 0.007), status of pre-traumatic activities of daily living (ADL) (p = 0.037), and serum albumin concentrations (p = 0.011). Logistic regression analysis showed no significant differences in variables in the stratified group of patients who improved to AIS-D. Meanwhile, serum albumin was a significant variable in patients who improved to AIS-E (p = 0.026; OR: 6.20, pre-traumatic ADL was omitted due to data skewness). CONCLUSIONS: Most older patients with incomplete AIS-C SCI demonstrated at least 1 grade of neurological improvement. However, <10% of patients achieved complete recovery. Key predictors of complete recovery were high serum albumin levels on admission and independent pre-traumatic ADL. SPONSORSHIP: No funding was received for this study.

  12. Impact of malnutrition on mortality and neurological recovery of older patients with spinal cord injury. 国際誌

    Koji Tamai, Hidetomi Terai, Hiroaki Nakamura, Noriaki Yokogawa, Takeshi Sasagawa, Hiroaki Nakashima, Naoki Segi, Sadayuki Ito, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Kota Watanabe, Junichi Yamane, Kazuki Takeda, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Akiyoshi Kuroda, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Shiro Imagama, Satoshi Kato

    Scientific reports　14　(1)　5853-5853　2024年3月11日

    DOI： 10.1038/s41598-024-56527-y 　

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    This retrospective cohort study established malnutrition's impact on mortality and neurological recovery of older patients with cervical spinal cord injury (SCI). It included patients aged ≥ 65 years with traumatic cervical SCI treated conservatively or surgically. The Geriatric Nutritional Risk Index was calculated to assess nutritional-related risk. Overall, 789 patients (mean follow-up: 20.1 months) were examined and 47 had major nutritional-related risks on admission. One-year mortality rate, median survival time, neurological recovery, and activities of daily living (ADL) at 1 year post-injury were compared between patients with major nutrition-related risk and matched controls selected using 1:2 propensity score matching to adjust for age, pre-traumatic neurological impairment, and activity. In the Kaplan-Meier analysis, the median survival times were 44.9 and 76.5 months for patients with major nutrition-related risk and matched controls, respectively (p = 0.015). Matched controls had more individuals with a neurological improvement of American Spinal Injury Association Impairment Scale ≥ 1 grade (p = 0.039) and independence in ADL at 1 year post-injury than patients with major nutrition-related risk (p < 0.05). In conclusion, 6% of older patients with cervical SCI had major nutrition-related risks; they showed a significantly higher 1 year mortality rate, shorter survival time, poorer neurological improvement, and lower ADL at 1 year post-injury than matched controls.

  13. Influence of the timing of surgery for cervical spinal cord injury without bone injury in the elderly: A retrospective multicenter study.

    Satoshi Nori, Kota Watanabe, Kazuki Takeda, Junichi Yamane, Hitoshi Kono, Noriaki Yokogawa, Takeshi Sasagawa, Kei Ando, Hiroaki Nakashima, Naoki Segi, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Hidetomi Terai, Koji Tamai, Eiki Shirasawa, Gen Inoue, Katsuhito Kiyasu, Yoichi Iizuka, Eiji Takasawa, Haruki Funao, Takashi Kaito, Toshitaka Yoshii, Masayuki Ishihara, Seiji Okada, Shiro Imagama, Satoshi Kato

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　29　(2)　480-485　2024年3月

    DOI： 10.1016/j.jos.2023.01.004 　

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    BACKGROUND: Although previous studies have demonstrated the advantages of early surgery for traumatic spinal cord injury (SCI), the appropriate surgical timing for cervical SCIs (CSCIs) without bone injury remains controversial. Here, we investigated the influence of relatively early surgery within 48 h of injury on the neurological recovery of elderly patients with CSCI and no bone injury. METHODS: In this retrospective multicenter study, we reviewed data from 159 consecutive patients aged ≥65 years with CSCI without bone injury who underwent surgery in participating centers between 2010 and 2020. Patients were followed up for at least 6 months following CSCI. We divided patients into relatively early (≤48 h after CSCI, n = 24) and late surgery (>48 h after CSCI, n = 135) groups, and baseline characteristics and neurological outcomes were compared between them. Multivariate analysis was performed to identify factors associated with neurological recovery. RESULTS: The relatively early surgery group demonstrated a lower prevalence of cardiac disease, poorer baseline American Spinal Injury Association (ASIA) impairment scale grade, and lower baseline ASIA motor score (AMS) than those of the late surgery group (P < 0.030, P < 0.001, and P < 0.001, respectively). Although the AMS was lower in the relatively early surgery group at 6 months following injury (P = 0.001), greater improvement in this score from baseline to 6-months post injury was observed (P = 0.010). Multiple linear regression analysis revealed that relatively early surgery did not affect postoperative improvement in AMS, rather, lower baseline AMS was associated with better AMS improvement (P < 0.001). Delirium (P = 0.006), pneumonia (P = 0.030), and diabetes mellitus (P = 0.039) negatively influenced postoperative improvement. CONCLUSIONS: Although further validation by future studies is required, relatively early surgery did not show a positive influence on neurological recovery after CSCI without bone injury in the elderly.

  14. Early Versus Delayed Surgery for Elderly Traumatic Cervical Spinal Injury: A Nationwide Multicenter Study in Japan. 国際誌

    Naoki Segi, Hiroaki Nakashima, Sadayuki Ito, Noriaki Yokogawa, Takeshi Sasagawa, Kota Watanabe, Satoshi Nori, Toru Funayama, Fumihiko Eto, Hideaki Nakajima, Yoshinori Terashima, Ryosuke Hirota, Ko Hashimoto, Yoshito Onoda, Takeo Furuya, Atsushi Yunde, Shota Ikegami, Masashi Uehara, Hidenori Suzuki, Yasuaki Imajo, Hiroshi Uei, Hirokatsu Sawada, Kenichi Kawaguchi, Kazuo Nakanishi, Nobuyuki Suzuki, Yasushi Oshima, Tomohiko Hasegawa, Yoichi Iizuka, Hitoshi Tonomura, Hidetomi Terai, Koji Akeda, Shoji Seki, Masayuki Ishihara, Gen Inoue, Haruki Funao, Toshitaka Yoshii, Takashi Kaito, Katsuhito Kiyasu, Hiroyuki Tominaga, Kenichiro Kakutani, Daisuke Sakai, Tetsuro Ohba, Bungo Otsuki, Masashi Miyazaki, Kenta Murotani, Seiji Okada, Shiro Imagama, Satoshi Kato

    Global spine journal　21925682241227430-21925682241227430　2024年1月16日

    DOI： 10.1177/21925682241227430 　

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    STUDY DESIGN: Retrospective multicenter study. OBJECTIVES: The effectiveness of early surgery for cervical spinal injury (CSI) has been demonstrated. However, whether early surgery improves outcomes in the elderly remains unclear. This study investigated whether early surgery for CSI in elderly affects complication rates and neurological outcomes. METHODS: This retrospective multicenter study included 462 patients. We included patients with traumatic acute cervical spinal cord injury aged ≥65 years who were treated surgically, whereas patients with American Spinal Injury Association (ASIA) Impairment Scale E, those with unknown operative procedures, and those waiting for surgery for >1 month were excluded. The minimum follow-up period was 6 months. Sixty-five patients (early group, 14.1%) underwent surgical treatment within 24 hours, whereas the remaining 397 patients (85.9%) underwent surgery on a standby basis (delayed group). The propensity score-matched cohorts of 63 cases were compared. RESULTS: Patients in the early group were significantly younger, had significantly more subaxial dislocations (and fractures), tetraplegia, significantly lower ASIA motor scores, and ambulatory abilities 6 months after injury. However, no significant differences in the rate of complications, ambulatory abilities, or ASIA Impairment Scale scores 6 months after injury were observed between the matched cohorts. At 6 months after injury, 61% of the patients in the early group (25% unsupported and 36% supported) and 53% of the patients in the delayed group (34% unsupported and 19% supported) were ambulatory. CONCLUSIONS: Early surgery is possible for CSI in elderly patients as the matched cohort reveals no significant difference in complication rates and neurological or ambulatory recovery between the early and delayed surgery groups.

  15. Prognostic impact of respiratory dysfunction in elderly patients with cervical spinal cord injury and/or fractures: a multicenter survey. 国際誌

    Ryosuke Hirota, Yoshinori Terashima, Hirofumi Ohnishi, Toshihiko Yamashita, Noriaki Yokogawa, Takeshi Sasagawa, Hiroaki Nakashima, Naoki Segi, Sadayuki Ito, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Kota Watanabe, Satoshi Nori, Kazuki Takeda, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Hidetomi Terai, Koji Tamai, Akiyoshi Kuroda, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Shiro Imagama, Satoshi Kato

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society　32　(10)　3522-3532　2023年10月

    DOI： 10.1007/s00586-023-07828-9 　

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    PURPOSE: To investigate the impact of early post-injury respiratory dysfunction for neurological and ambulatory ability recovery in patients with cervical spinal cord injury (SCI) and/or fractures. METHODS: We included 1,353 elderly patients with SCI and/or fractures from 78 institutions in Japan. Patients who required early tracheostomy and ventilator management and those who developed respiratory complications were included in the respiratory dysfunction group, which was further classified into mild and severe respiratory groups based on respiratory weaning management. Patient characteristics, laboratory data, neurological impairment scale scores, complications at injury, and surgical treatment were evaluated. We performed a propensity score-matched analysis to compare neurological outcomes and mobility between groups. RESULTS: Overall, 104 patients (7.8%) had impaired respiratory function. In propensity score-matched analysis, the respiratory dysfunction group had a lower home discharge and ambulation rates (p = 0.018, p = 0.001, respectively), and higher rate of severe paralysis (p < 0.001) at discharge. At the final follow-up, the respiratory dysfunction group had a lower ambulation rate (p = 0.004) and higher rate of severe paralysis (p < 0.001). Twenty-six patients with severe disability required respiratory management for up to 6 months post-injury and died of respiratory complications. The mild and severe respiratory dysfunction groups had a high percentage of severe paraplegic cases with low ambulatory ability; there was no significant difference between them. The severe respiratory dysfunction group tended to have a poorer prognosis. CONCLUSION: Respiratory dysfunction in elderly patients with SCI and/or cervical fracture in the early post-injury period reflects the severity of the condition and may be a useful prognostic predictor.

  16. Prognosis of Cervical Diffuse Idiopathic Skeletal Hyperostosis-Related Spine Injuries in Elderly Patients: Analyses of Both Fracture and Spinal Cord Injury Without Fracture. 国際誌

    Naoki Segi, Hiroaki Nakashima, Masaaki Machino, Sadayuki Ito, Noriaki Yokogawa, Takeshi Sasagawa, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Kota Watanabe, Satoshi Nori, Kazuki Takeda, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Hidetomi Terai, Koji Tamai, Eiki Shirasawa, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Haruki Funao, Yasushi Oshima, Toshitaka Yoshii, Takashi Kaito, Daisuke Sakai, Tetsuro Ohba, Shoji Seki, Bungo Otsuki, Masayuki Ishihara, Masashi Miyazaki, Seiji Okada, Shiro Imagama, Satoshi Kato

    Global spine journal　21925682231186757-21925682231186757　2023年7月3日

    DOI： 10.1177/21925682231186757 　

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    STUDY DESIGN: Retrospective multicenter study. OBJECTIVE: The purpose of this study was to compare the prognosis of elderly patients with injuries related to cervical diffuse idiopathic skeletal hyperostosis (cDISH) to matched control for each group, with and without fractures. METHODS: The current multicenter study was a retrospective analysis of 140 patients aged 65 years or older with cDISH-related cervical spine injuries; 106 fractures and 34 spinal cord injuries without fracture were identified. Propensity score-matched cohorts from 1363 patients without cDISH were generated and compared. Logistic regression analysis was performed to determine the risk of early mortality for patients with cDISH-related injury. RESULTS: Patients with cDISH-related injuries with fracture did not differ significantly in the incidence of each complication and ambulation or severity of paralysis compared to matched controls. In patients with cDISH-related injury without fracture, those who were nonambulatory at discharge comprised 55% vs 34% of controls, indicating significantly poorer ambulation in those with cDISH-related injuries (P = .023). There was no significant difference in the incidence of complications and ambulation or paralysis severity at 6 months as compared with controls. Fourteen patients died within 3 months. Logistic regression analysis identified complete paralysis (odds ratio [OR] 36.99) and age (OR 1.24) as significant risk factors for mortality. CONCLUSIONS: The current study showed no significant differences in the incidence of complications, ambulation outcomes between patients with cDISH-related injury with fracture and matched controls, and that the ambulation at discharge for patients with cDISH-related injury without fractures were significantly inferior to those of matched controls.

  17. Delirium Risk Score in Elderly Patients with Cervical Spinal Cord Injury and/or Cervical Fracture. 国際誌

    Koji Tamai, Hidetomi Terai, Hiroaki Nakamura, Noriaki Yokogawa, Takeshi Sasagawa, Hiroaki Nakashima, Naoki Segi, Sadayuki Ito, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Kota Watanabe, Junichi Yamane, Kazuki Takeda, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Akiyoshi Kuroda, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Shiro Imagama, Satoshi Kato

    Journal of clinical medicine　12　(6)　2023年3月20日

    DOI： 10.3390/jcm12062387 　

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    The number of elderly patients with cervical trauma is increasing. Such patients are considered to be at high risk for delirium, which is an acute neuropsychological disorder that reduces the patient's capacity to interact with their environment due to impairments in cognition. This study aimed to establish a risk score that predicts delirium in elderly patients with cervical SCI and/or cervical fracture regardless of treatment type. This retrospective cohort study included 1512 patients aged ≥65 years with cervical SCI and/or cervical fracture. The risk factors for delirium according to treatment type (surgical or conservative) were calculated using multivariate logistic regression. A delirium risk score was established as the simple arithmetic sum of points assigned to variables that were significant in the multivariate analyses. Based on the statistical results, the delirium risk score was defined using six factors: old age (≥80 years), hypoalbuminemia, cervical fracture, major organ injury, dependence on pre-injury mobility, and comorbid diabetes. The score's area under the curve for the prediction of delirium was 0.66 (p < 0.001). Although the current scoring system must be validated with an independent dataset, the system remains beneficial because it can be used after screening examinations upon hospitalization and before deciding the treatment strategy.

  18. Effects of Dementia on Outcomes after Cervical Spine Injuries in Elderly Patients: Evaluation of 1512 Cases in a Nationwide Multicenter Study in Japan. 国際誌

    Yohei Yamada, Noriaki Yokogawa, Satoshi Kato, Takeshi Sasagawa, Hiroyuki Tsuchiya, Hiroaki Nakashima, Naoki Segi, Sadayuki Ito, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Junichi Yamane, Satoshi Nori, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Hidetomi Terai, Koji Tamai, Akiyoshi Kuroda, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Shiro Imagama, Kota Watanabe

    Journal of clinical medicine　12　(5)　2023年2月27日

    DOI： 10.3390/jcm12051867 　

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    We aimed to retrospectively investigate the demographic characteristics and short-term outcomes of traumatic cervical spine injuries in patients with dementia. We enrolled 1512 patients aged ≥ 65 years with traumatic cervical injuries registered in a multicenter study database. Patients were divided into two groups according to the presence of dementia, and 95 patients (6.3%) had dementia. Univariate analysis revealed that the dementia group comprised patients who were older and predominantly female and had lower body mass index, higher modified 5-item frailty index (mFI-5), lower pre-injury activities of daily living (ADLs), and a larger number of comorbidities than patients without dementia. Furthermore, 61 patient pairs were selected through propensity score matching with adjustments for age, sex, pre-injury ADLs, American Spinal Injury Association Impairment Scale score at the time of injury, and the administration of surgical treatment. In the univariate analysis of the matched groups, patients with dementia had significantly lower ADLs at 6 months and a higher incidence of dysphagia up to 6 months than patients without dementia. Kaplan-Meier analysis revealed that patients with dementia had a higher mortality than those without dementia until the last follow-up. Dementia was associated with poor ADLs and higher mortality rates after traumatic cervical spine injuries in elderly patients.

  19. Characteristics of the cervical spine and cervical cord injuries in older adults with cervical ossification of the posterior longitudinal ligament. 国際誌

    Shun Okuwaki, Toru Funayama, Masao Koda, Fumihiko Eto, Akihiro Yamaji, Noriaki Yokogawa, Takeshi Sasagawa, Kei Ando, Hiroaki Nakashima, Naoki Segi, Kota Watanabe, Satoshi Nori, Kazuki Takeda, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Hidetomi Terai, Koji Tamai, Eiki Shirasawa, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Shiro Imagama, Satoshi Kato

    Scientific reports　13　(1)　2689-2689　2023年2月15日

    DOI： 10.1038/s41598-023-29877-2 　

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    Although the incidence of cervical spinal cord injury (CSCI) with ossification of the posterior longitudinal ligament (OPLL) has increased in older adults, its etiology and neurological outcomes remain unknown. We identified OPLL characteristics and determined whether they influence neurological severity and improvement of CSCI in older patients. This multicenter retrospective cohort study identified 1512 patients aged ≥ 65 years diagnosed with CSCI on admission during 2010-2020. We analyzed CSCI etiology in OPLL patients. We performed propensity score-adjusted analyses to compare neurological outcomes between patients with and without OPLL. Cases were matched based on variables influencing neurological prognosis. The primary neurological outcome was rated according to the American Spine Injury Association (ASIA) impairment scale (AIS) and ASIA motor score (AMS). In 332 OPLL patients, the male-to-female ratio was approximately 4:1. Half of all patients displayed low-energy trauma-induced injury and one-third had CSCI without a bony injury. Propensity score matching created 279 pairs. There was no significant difference in the AIS grade and AMS between patients with and without OPLL during hospitalization, 6 months, and 12 months following injury. OPLL patients tended to exhibit worse neurological findings during injury; nevertheless, OPLL was not associated with poor neurological improvement in older CSCI patients.

  20. Risk Factors for Early Mortality in Older Patients with Traumatic Cervical Spine Injuries-A Multicenter Retrospective Study of 1512 Cases. 国際誌

    Motoya Kobayashi, Noriaki Yokogawa, Satoshi Kato, Takeshi Sasagawa, Hiroyuki Tsuchiya, Hiroaki Nakashima, Naoki Segi, Sadayuki Ito, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Junichi Yamane, Satoshi Nori, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Hidetomi Terai, Koji Tamai, Akiyoshi Kuroda, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Shiro Imagama, Kota Watanabe

    Journal of clinical medicine　12　(2)　2023年1月16日

    DOI： 10.3390/jcm12020708 　

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    For older patients with decreased reserve function, traumatic cervical spine injuries frequently lead to early mortality. However, the prognostic factors for early mortality remain unclear. This study included patients aged ≥65 years and hospitalized for treatment of traumatic cervical spine injuries in 78 hospitals between 2010 and 2020. Early mortality was defined as death within 90 days after injury. We evaluated the relationship between early mortality and the following factors: age, sex, body mass index, history of drinking and smoking, injury mechanisms, presence of a cervical spine fracture and dislocation, cervical ossification of the posterior longitudinal ligament, diffuse idiopathic skeletal hyperostosis, American Spinal Injury Association Impairment Scale, concomitant injury, pre-existing comorbidities, steroid administration, and treatment plan. Overall, 1512 patients (mean age, 75.8 ± 6.9 years) were included in the study. The early mortality rate was 4.0%. Multivariate analysis identified older age (OR = 1.1, p < 0.001), male sex (OR = 3.7, p = 0.009), cervical spine fracture (OR = 4.2, p < 0.001), complete motor paralysis (OR = 8.4, p < 0.001), and chronic kidney disease (OR = 5.3, p < 0.001) as risk factors for early mortality. Older age, male sex, cervical spine fracture, complete motor paralysis, and chronic kidney disease are prognostic factors for early mortality in older patients with traumatic cervical spine injuries.

  21. Epidemiology of Cervical Fracture/Cervical Spinal Cord Injury and Changes in Surgical Treatment Modalities in Elderly Individuals During a 10-year Period: A Nationwide Multicenter Study in Japan. 国際誌

    Naoki Segi, Hiroaki Nakashima, Masaaki Machino, Sadayuki Ito, Noriaki Yokogawa, Takeshi Sasagawa, Toru Funayama, Fumihiko Eto, Kota Watanabe, Satoshi Nori, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiko Hasegawa, Tomohiro Yamada, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Hidetomi Terai, Koji Tamai, Gen Inoue, Eiki Shirasawa, Kenichiro Kakutani, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Haruki Funao, Yasushi Oshima, Toshitaka Yoshii, Takashi Kaito, Daisuke Sakai, Tetsuro Ohba, Shoji Seki, Bungo Otsuki, Masayuki Ishihara, Masashi Miyazaki, Seiji Okada, Shiro Imagama, Satoshi Kato

    Global spine journal　21925682231151643-21925682231151643　2023年1月13日

    DOI： 10.1177/21925682231151643 　

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    STUDY DESIGN: Retrospective multicenter study. OBJECTIVES: To investigate changes over a 10-years period in the profile of cervical spine and spinal cord injuries among the elderly in Japan. METHODS: The current multicenter study was a retrospective analysis of inpatients aged ≥65 years, suffering cervical fracture (CF) and/or cervical spinal cord injury (CSCI). We analyzed 1413 patients' epidemiology (from 2010 to 2019). Moreover, 727 patients who underwent surgical treatment were analyzed in 2 groups: the early (2010-2014) and late period (2015-2019). RESULTS: Both the number of patients and number of surgical patients showed a significant increasing trend (P < .001), while the mean age, the distribution of injury levels and paralysis severity, and the proportion of surgical indications remained the same. The number of surgical patients doubled from 228 to 499 from the early to late periods. Posterior surgery was the most common approach (90.4%), instrumentation surgery with screws increased significantly, and the range of fusion was significantly longer in the late period (2.1 vs 2.7 levels, P = .001). Significantly worsening neurological symptoms were recorded in the late period (1.3% vs 5.8%, P = .006), with C5 palsy being the major one. Otherwise, perioperative, major, and other complications, including mortality, did not differ significantly in incidence. CONCLUSIONS: Both the number of elderly CF and/or CSCI patients and number of patients undergoing surgery increased dramatically over the decade without any change in profile. Instrumentation surgeries with screws increased, without an increase in systemic complications.

  22. 肘外側尺側側副靱帯の尺骨付着部損傷により術後に後外側不安定性が残存したterrible triad injuryの一例

    小暮 敦史, 菅谷 岳広, 小野田 祥人, 相澤 俊峰

    日本肘関節学会雑誌　30　(2)　166-170　2023年

    出版者・発行元： 日本肘関節学会

    ISSN：1349-7324

    eISSN：2434-2262

  23. A modified minimally invasive surgery for thoracic pyogenic spondylitis: Percutaneous pedicle screw fixation in combination with a vertebral debridement in a separate posterolateral approach—A case report

    Yuki Sato, Ko Hashimoto, Michiharu Matsuda, Takahiro Onoki, Masayuki Kamimura, Kohei Takahashi, Yoshito Onoda, Daisuke Chiba, Yu Mori, Haruo Kanno, Nobuyuki Yamamoto, Toshimi Aizawa

    Clinical Case Reports　10　(12)　2022年12月

    出版者・発行元： Wiley

    DOI： 10.1002/ccr3.6710 　

    ISSN：2050-0904

    eISSN：2050-0904

  24. Differences in clinical characteristics of cervical spine injuries in older adults by external causes: a multicenter study of 1512 cases. 国際誌

    Noriaki Yokogawa, Satoshi Kato, Takeshi Sasagawa, Hiroyuki Hayashi, Hiroyuki Tsuchiya, Kei Ando, Hiroaki Nakashima, Naoki Segi, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Satoshi Nori, Junichi Yamane, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Hidetomi Terai, Koji Tamai, Eiki Shirasawa, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Shiro Imagama, Kota Watanabe

    Scientific reports　12　(1)　15867-15867　2022年9月23日

    DOI： 10.1038/s41598-022-19789-y 　

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    Although traumatic cervical spine injuries in older adults are commonly caused by minor traumas, such as ground-level falls, their prognosis is often unfavorable. Studies examining the clinical characteristics of cervical spine injuries in older adults according to the external cause of injury are lacking. This study included 1512 patients of ≥ 65 years of age with traumatic cervical spine injuries registered in a Japanese nationwide multicenter database. The relationship between the external causes and clinical characteristics, as well as factors causing unfavorable outcomes at the ground-level falls, were retrospectively reviewed and examined. When fall-induced cervical spine injuries were categorized and compared based on fall height, the patients' backgrounds and injury statuses differed significantly. Of note, patients injured from ground-level falls tended to have poorer pre-injury health conditions, such as medical comorbidities and frailty, compared with those who fell from higher heights. For ground-level falls, the mortality, walking independence, and home-discharge rates at 6 months post-injury were 9%, 67%, and 80%, respectively, with preexisting medical comorbidities and frailty associated with unfavorable outcomes, independent of age or severity of neurological impairment at the time of injury.

  25. A multicenter study of 1-year mortality and walking capacity after spinal fusion surgery for cervical fracture in elderly patients. 国際誌

    Takeshi Sasagawa, Noriaki Yokogawa, Hiroyuki Hayashi, Hiroyuki Tsuchiya, Kei Ando, Hiroaki Nakashima, Naoki Segi, Kota Watanabe, Satoshi Nori, Kazuki Takeda, Takeo Furuya, Atsushi Yunde, Shota Ikegami, Masashi Uehara, Hidenori Suzuki, Yasuaki Imajo, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Ko Hashimoto, Yoshito Onoda, Kenichiro Kakutani, Yuji Kakiuchi, Nobuyuki Suzuki, Kenji Kato, Yoshinori Terashima, Ryosuke Hirota, Tomohiro Yamada, Tomohiko Hasegawa, Kenichi Kawaguchi, Yohei Haruta, Shoji Seki, Hitoshi Tonomura, Munehiro Sakata, Hiroshi Uei, Hirokatsu Sawada, Hiroyuki Tominaga, Hiroto Tokumoto, Takashi Kaito, Yoichi Iizuka, Eiji Takasawa, Yasushi Oshima, Hidetomi Terai, Koji Tamai, Bungo Otsuki, Masashi Miyazaki, Hideaki Nakajima, Kazuo Nakanishi, Kosuke Misaki, Gen Inoue, Katsuhito Kiyasu, Koji Akeda, Norihiko Takegami, Toshitaka Yoshii, Masayuki Ishihara, Seiji Okada, Yasuchika Aoki, Katsumi Harimaya, Hideki Murakami, Ken Ishii, Seiji Ohtori, Shiro Imagama, Satoshi Kato

    BMC musculoskeletal disorders　23　(1)　798-798　2022年8月20日

    DOI： 10.1186/s12891-022-05752-5 　

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    BACKGROUND: The 1-year mortality and functional prognoses of patients who received surgery for cervical trauma in the elderly remains unclear. The aim of this study is to investigate the rates of, and factors associated with mortality and the deterioration in walking capacity occurring 1 year after spinal fusion surgery for cervical fractures in patients 65 years of age or older. METHODS: Three hundred thirteen patients aged 65 years or more with a traumatic cervical fracture who received spinal fusion surgery were enrolled. The patients were divided into a survival group and a mortality group, or a maintained walking capacity group and a deteriorated walking capacity group. We compared patients' backgrounds, trauma, and surgical parameters between the two groups. To identify factors associated with mortality or a deteriorated walking capacity 1 year postoperatively, a multivariate logistic regression analysis was conducted. RESULTS: One year postoperatively, the rate of mortality was 8%. A higher Charlson comorbidity index (CCI) score, a more severe the American Spinal Cord Injury Association impairment scale (AIS), and longer surgical time were identified as independent factors associated with an increase in 1-year mortality. The rate of deterioration in walking capacity between pre-trauma and 1 year postoperatively was 33%. A more severe AIS, lower albumin (Alb) and hemoglobin (Hb) values, and a larger number of fused segments were identified as independent factors associated with the increased risk of deteriorated walking capacity 1 year postoperatively. CONCLUSIONS: The 1-year rate of mortality after spinal fusion surgery for cervical fracture in patients 65 years of age or older was 8%, and its associated factors were a higher CCI score, a more severe AIS, and a longer surgical time. The rate of deterioration in walking capacity was 33%, and its associated factors were a more severe AIS, lower Alb, lower Hb values, and a larger number of fused segments.

  26. Factors Affecting the Waiting Time from Injury to Surgery in Elderly Patients with a Cervical Spine Injury: A Japanese Multicenter Survey. 国際誌

    Masashi Uehara, Shota Ikegami, Takashi Takizawa, Hiroki Oba, Noriaki Yokogawa, Takeshi Sasagawa, Kei Ando, Hiroaki Nakashima, Naoki Segi, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Kota Watanabe, Satoshi Nori, Kazuki Takeda, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Hidetomi Terai, Koji Tamai, Eiki Shirasawa, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Shiro Imagama, Satoshi Kato

    World neurosurgery　166　e815-e822　2022年8月2日

    DOI： 10.1016/j.wneu.2022.07.104 　

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    OBJECTIVE: The management of cervical spine injuries in the elderly is often complicated by the presence of multiple medical comorbidities, and it is not uncommon for preoperative testing to reveal other conditions that require the postponement of surgery. However, the factors that affect the waiting time from injury to surgery have not been clarified. The purpose of this multicenter database study was to analyze the clinical features and identify the factors affecting the number of days waited between injury and surgery in elderly patients with a cervical spine injury. METHODS: We retrospectively reviewed the case histories of 1512 Japanese patients with a cervical spinal injury, who were seen at 33 institutions. After excluding patients who were not initially receiving a surgery for cervical spinal injury, 694 patients were ultimately analyzed. Based on a multivariate mixed model, we determined the factors related to the number of days from injury to surgery. RESULTS: The mean time from injury to surgery was 12.3 days. Multivariate analysis revealed delays of 10.7 days for a renal disorder, 7.3 days for anticoagulant use, and 15.2 days for non-surgical thoracolumbar fracture as factors prolonging wait time. In contrast, a C3 or lower spine injury was significantly associated with a shortening of 9.5 days to surgery. CONCLUSIONS: This multicenter database study identified several factors influencing the time between injury and cervical spine surgery in elderly patients. While renal impairment, anticoagulant use, and non-surgical thoracolumbar fracture may increase the number of days to surgery, trauma to C3 or lower may expedite surgical treatment.

  27. Does surgery improve neurological outcomes in older individuals with cervical spinal cord injury without bone injury? A multicenter study. 国際誌

    Satoshi Nori, Kota Watanabe, Kazuki Takeda, Junichi Yamane, Hitoshi Kono, Noriaki Yokogawa, Takeshi Sasagawa, Kei Ando, Hiroaki Nakashima, Naoki Segi, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Hidetomi Terai, Koji Tamai, Eiki Shirasawa, Gen Inoue, Katsuhito Kiyasu, Yoichi Iizuka, Eiji Takasawa, Haruki Funao, Takashi Kaito, Toshitaka Yoshii, Masayuki Ishihara, Seiji Okada, Shiro Imagama, Satoshi Kato

    Spinal cord　60　(10)　895-902　2022年6月11日

    DOI： 10.1038/s41393-022-00818-6 　

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    STUDY DESIGN: Retrospective multicenter study. OBJECTIVES: To investigate the neurological outcomes of older individuals treated with surgery versus conservative treatment for cervical spinal cord injury (CSCI) without bone injury. SETTING: Thirty-three medical institutions in Japan. METHODS: This study included 317 consecutive persons aged ≥65 years with CSCI without bone injury in participating institutes between 2010 and 2020. The participants were followed up for at least 6 months after the injury. Individuals were divided into surgery (n = 114) and conservative treatment (n = 203) groups. To compare neurological outcomes and complications between the groups, propensity score matching of the baseline factors (characteristics, comorbidities, and neurological function) was performed. RESULTS: After propensity score matching, the surgery and conservative treatment groups comprised 89 individuals each. Surgery was performed at a median of 9.0 (3-17) days after CSCI. Baseline factors were comparable between groups, and the standardized difference in the covariates in the matched cohort was <10%. The American Spinal Injury Association (ASIA) impairment scale grade and ASIA motor score (AMS) 6 months after injury and changes in the AMS from baseline to 6 months after injury were not significantly different between groups (P = 0.63, P = 0.24, and P = 0.75, respectively). Few participants who underwent surgery demonstrated perioperative complications such as dural tear (1.1%), surgical site infection (2.2%), and C5 palsy (5.6%). CONCLUSION: Conservative treatment is suggested to be a more favorable option for older individuals with CSCI without bone injuries, but this finding requires further validation.

  28. 多発外傷・多発骨折に合併し初期評価で見落とされた膝関節靱帯損傷

    菅谷 岳広, 小暮 敦史, 小野田 祥人, 秋 貴史, 上村 雅之, 相澤 俊峰

    東北整形災害外科学会雑誌　65　(1)　192-193　2022年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN：1348-8694

  29. Prognostic Factors for Respiratory Dysfunction for Cervical Spinal Cord Injury and/or Cervical Fractures in Elderly Patients: A Multicenter Survey. 国際誌

    Ryosuke Hirota, Yoshinori Terashima, Hirofumi Ohnishi, Toshihiko Yamashita, Noriaki Yokogawa, Takeshi Sasagawa, Kei Ando, Hiroaki Nakashima, Naoki Segi, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Kota Watanabe, Junichi Yamane, Kazuki Takeda, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Hidetomi Terai, Koji Tamai, Eiki Shirasawa, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Shiro Imagama, Satoshi Kato

    Global spine journal　21925682221095470-21925682221095470　2022年5月26日

    DOI： 10.1177/21925682221095470 　

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    STUDY DESIGN: Retrospective Cohort Study. OBJECTIVE: The purpose of this study was to investigate the prognosis of respiratory function in elderly patients with cervical spinal cord injury (SCI) and to identify predictive factors. METHODS: We included 1353 cases of elderly cervical SCI patients collected from 78 institutions in Japan. Patients who required early tracheostomy and ventilator management and those who developed respiratory complications were defined as the respiratory disability group. Patients' background characteristics, injury mechanism, injury form, neurological disability, complications, and treatment methods were compared between the disability and non-disability groups. Multiple logistic regression analysis was used to examine the independent factors. Patients who required respiratory management for 6 months or longer after injury and those who died of respiratory complications were classified into the severe disability group and were compared with minor cases who were weaned off the respirator. RESULTS: A total of 104 patients (7.8%) had impaired respiratory function. Comparisons between the disabled and non-disabled groups and between the severe and mild injury groups yielded distinct trends. In multiple logistic regression analysis, age, blood glucose level, presence of ossification of posterior longitudinal ligament (OPLL), anterior vertebral hematoma, and critical paralysis were selected as independent risk factors. CONCLUSION: Age, OPLL, severe paralysis, anterior vertebral hematoma, hypoalbuminemia, and blood glucose level at the time of injury were independent factors for respiratory failure. Hyperglycemia may have a negative effect on respiratory function in this condition.

  30. Innovation of Surgical Techniques for Screw Fixation in Patients with Osteoporotic Spine. 国際誌

    Haruo Kanno, Yoshito Onoda, Ko Hashimoto, Toshimi Aizawa, Hiroshi Ozawa

    Journal of clinical medicine　11　(9)　2022年5月4日

    DOI： 10.3390/jcm11092577 　

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    Osteoporosis is a common disease in elderly populations and is a major public health problem worldwide. It is not uncommon for spine surgeons to perform spinal instrumented fusion surgeries for osteoporotic patients. However, in patients with severe osteoporosis, instrumented fusion may result in screw loosening, implant failure or nonunion because of a poor bone quality and decreased pedicle screw stability as well as increased graft subsidence risk. In addition, revision surgeries to correct failed instrumentation are becoming increasingly common in patients with osteoporosis. Therefore, techniques to enhance the fixation of pedicle screws are required in spinal surgeries for osteoporotic patients. To date, various instrumentation methods, such as a supplemental hook, sublaminar taping and sacral alar iliac screws, and modified screwing techniques have been available for reinforcing pedicle screw fixation. In addition, several materials, including polymethylmethacrylate and hydroxyapatite stick/granules, for insertion into prepared screw holes, can be used to enhance screw fixation. Many biomechanical tests support the effectiveness of these augmentation methods. We herein review the current therapeutic strategies for screw fixation and augmentation methods in the surgical treatment of patients with an osteoporotic spine.

  31. Reinforcement of Percutaneous Pedicle Screw Fixation with Hydroxyapatite Granules in Patients with Osteoporotic Spine: Biomechanical Performance and Clinical Outcomes. 国際誌

    Haruo Kanno, Yoshito Onoda, Ko Hashimoto, Toshimi Aizawa, Hiroshi Ozawa

    Medicina (Kaunas, Lithuania)　58　(5)　2022年4月23日

    DOI： 10.3390/medicina58050579 　

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    In percutaneous pedicle screw (PPS) fixation of the osteoporotic spine, rigid screw fixation obtaining strong stabilization is important for achieving successful treatment outcomes. However, in patients with severe osteoporosis, it is difficult to obtain PPS fixation with sufficient stability. PPS fixation has potential disadvantages with respect to maintaining secure stabilization in comparison to conventional pedicle screw fixation. In PPS fixation, bone grafting to achieve posterior spine fusion is generally not applicable and transverse connectors between the rods cannot be used to reinforce the fixation. Various augmentation methods, including additional hooks, sublaminar bands, and hydroxyapatite (HA) sticks, are available for conventional pedicle screw fixation. On the other hand, there has been no established augmentation method for PPS fixation. Recently, we developed a novel augmentation technique for PPS fixation using HA granules. This technique allows the percutaneous insertion of HA granules into the screw hole along the guidewire prior to insertion of the PPS. We have used this augmentation technique for PPS fixation in various spine surgeries in patients with osteoporosis. In our previous studies, biomechanical analyses demonstrated that PPS fixation was significantly enhanced by augmentation with HA granules in the osteoporotic lumbar spine. Furthermore, augmentation with HA granules was considered to decrease the incidence of screw loosening and implant failure following PPS fixation in patients with osteoporotic spine. In this article, we describe the surgical procedures of the augmentation method using HA granules and summarize our data from the biomechanical analysis of augmentation for PPS fixation. We also review the surgical outcomes of PPS fixation with augmentation using HA granules.

  32. 【骨・関節感染症の治療戦略】検査・診断 新しい手法による診断 プレセプシンの術後感染症診断における有用性

    小圷 知明, 小野田 祥人, 相澤 俊峰

    別冊整形外科　(81)　103-107　2022年4月

    出版者・発行元： (株)南江堂

    ISSN：0287-1645

    eISSN：2433-4316

  33. Factors Associated with Thickening of the Ligamentum Flavum on Magnetic Resonance Imaging in Patients with Lumbar Spinal Canal Stenosis. 国際誌

    Yutaka Yabe, Yoshihiro Hagiwara, Masahiro Tsuchiya, Yoshito Onoda, Shinichirou Yoshida, Takahiro Onoki, Keisuke Ishikawa, Daisuke Kurosawa, Eiichi Murakami

    Spine　47　(14)　1036-1041　2022年2月4日

    DOI： 10.1097/BRS.0000000000004341 　

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    STUDY DESIGN: Experimental study of LF thickness among patients with LSCS. OBJECTIVES: To elucidate the factors associated with thickening of the LF on magnetic resonance imaging (MRI). SUMMARY OF BACKGROUND DATA: Thickening of the LF is a major contributor to LSCS. This thickening is attributed to tissue hypertrophy or buckling of the ligament, and there may be several associated factors on MRI; however, these factors remain unclear. METHODS: We studied the LF in 56 patients (a total of 106 ligaments) with LSCS, who underwent decompressive surgery; among them, 23 were receiving haemodialysis. The Pearson correlation coefficient was used to assess relationships between the thickness of the LF on MRI and the thickness of the LF tissue, age, disc height, disc degeneration, and disc level. Patients were also categorised into 2 groups based on whether they were undergoing haemodialysis, and the relationships were assessed similarly. RESULTS: Among patients with LSCS, the thickness of the LF on MRI showed a significant positive linear relationship with the thickness of the LF tissue, and no association with disc height. Except for in those receiving haemodialysis, the thickness of the LF on MRI showed a significant positive relationship with age, disc degeneration, and disc level among patients with LSCS. CONCLUSION: In patients with LSCS, thickening of the LF on MRI appears to represent tissue hypertrophy. The association between the thickness of the LF on MRI and age, disc degeneration, and disc level may indicate simultaneous alterations of spine components along with aging that was cancelled by the effects of haemodialysis.

  34. 化膿性脊椎炎重症例に対する包括的治療戦略 敗血症診療ガイドラインの遵守と整形外科的治療介入

    小圷 知明, 小野田 祥人, 大柳 琢, 相澤 俊峰

    Journal of Spine Research　13　(2)　110-118　2022年2月

    出版者・発行元： (一社)日本脊椎脊髄病学会

    ISSN：1884-7137

    eISSN：2435-1563

  35. Is Blood Loss Greater in Elderly Patients under Antiplatelet or Anticoagulant Medication for Cervical Spine Injury Surgery? A Japanese Multicenter Survey.

    Masashi Uehara, Shota Ikegami, Takashi Takizawa, Hiroki Oba, Noriaki Yokogawa, Takeshi Sasagawa, Kei Ando, Hiroaki Nakashima, Naoki Segi, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Kota Watanabe, Satoshi Nori, Kazuki Takeda, Takeo Furuya, Sumihisa Orita, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Hidetomi Terai, Koji Tamai, Eiki Shirasawa, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Yasuchika Aoki, Katsumi Harimaya, Hideki Murakami, Ken Ishii, Seiji Ohtori, Shiro Imagama, Satoshi Kato

    Spine surgery and related research　6　(4)　366-372　2022年

    DOI： 10.22603/ssrr.2021-0183 　

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    Introduction: In elderly patients with cervical spinal cord injury, comorbidities such as cardiovascular and cerebrovascular diseases are common, with frequent administration of antiplatelet/anticoagulant (APAC) drugs. Such patients may bleed easily or unexpectedly during surgery despite prior withdrawal of APAC medication. Few reports have examined the precise relationship between intraoperative blood loss and history of APAC use regarding surgery for cervical spine injury in the elderly. The present multicenter database survey aimed to answer the question of whether the use of APAC drugs affected the amount of intraoperative blood loss in elderly patients with cervical spinal cord trauma. Methods: The case histories of 1512 patients with cervical spine injury at 33 institutes were retrospectively reviewed. After excluding cases without spinal surgery or known blood loss volume, 797 patients were enrolled. Blood volume loss was the outcome of interest. We calculated propensity scores using the inverse probability of treatment weighting (IPTW) method. As an alternative sensitivity analysis, linear mixed model analyses were conducted as well. Results: Of the 776 patients (mean age: 75.1±6.4 years) eligible for IPTW calculation, 157 (20.2%) were taking APAC medications before the injury. After weighting, mean estimated blood loss was 204 mL for non-APAC patients and 215 mL for APAC patients. APAC use in elderly patients was not significantly associated with surgical blood loss according to the IPTW method with propensity scoring or linear mixed model analyses. Thus, it appeared possible to perform surgery expecting comparable blood loss in APAC and non-APAC cases. Conclusions: This multicenter study revealed no significant increase in surgical blood loss in elderly patients with cervical trauma taking APAC drugs. Surgeons may be able to prioritize patient background, complications, and preexisting conditions over APAC use before injury when examining the surgical indications for cervical spine trauma in the elderly.

  36. Heterotopic ossification in a patient with paroxysmal sympathetic hyperactivity following multiple trauma complicated with vitamin D deficiency: a case report

    Takeaki Sato, Mayo Watanabe, Yoshito Onoda, Taku Oyanagi, Shigeki Kushimoto

    SURGICAL CASE REPORTS　6　(1)　2020年12月

    DOI： 10.1186/s40792-020-01031-4 　

    ISSN：2198-7793

  37. Joint hemorrhage accelerates cartilage degeneration in a rat immobilized knee model

    Yasuhito Sogi, Yutaka Yabe, Yoshihiro Hagiwara, Masahiro Tsuchiya, Yoshito Onoda, Takuya Sekiguchi, Nobuyuki Itaya, Shinichiro Yoshida, Toshihisa Yano, Kazuaki Suzuki, Takahiro Onoki, Eiji Itoi

    BMC MUSCULOSKELETAL DISORDERS　21　(1)　2020年11月

    DOI： 10.1186/s12891-020-03795-0 　

    eISSN：1471-2474

  38. 自然縮小した胸椎部砂時計腫の1例

    鈴木 学, 相澤 俊峰, 橋本 功, 菅野 晴夫, 小野田 祥人, 井樋 栄二

    東日本整形災害外科学会雑誌　32　(2)　198-201　2020年6月

    出版者・発行元： 東日本整形災害外科学会

    ISSN：1342-7784

    eISSN：2433-569X

  39. 内頸静脈穿刺手技により神経損傷が生じた1例

    芝崎 真人, 大野木 孝嘉, 小野田 祥人, 藤城 裕一, 樋口 和東, 中島 聡一, 山田 登, 本田 雅人

    東北整形災害外科学会雑誌　61　(1)　97-100　2018年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN：1348-8694

  40. 早期の集中的な歩行訓練が有効であった頸髄損傷不全麻痺例

    古西 幸夫, 竹山 大輔, 丹保 信人, 小野田 祥人

    竹田綜合病院医学雑誌　43　27-32　2017年11月

    出版者・発行元： (一財)竹田健康財団竹田綜合病院

    ISSN：1347-0183

  41. 初診時に脳梗塞が疑われた脊髄膿瘍の1例

    大野木 孝嘉, 小野田 祥人, 藤城 裕一, 樋口 和東, 中島 聡一, 山田 登, 本田 雅人

    竹田綜合病院医学雑誌　42　26-31　2016年12月

    出版者・発行元： (一財)竹田健康財団竹田綜合病院

    ISSN：1347-0183

  42. Joint haemorrhage partly accelerated immobilization-induced synovial adhesions and capsular shortening in rats

    Yoshito Onoda, Yoshihiro Hagiwara, Akira Ando, Takashi Watanabe, Eiichi Chimoto, Hideaki Suda, Yutaka Yabe, Yoshifumi Saijo, Eiji Itoi

    KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY　22　(11)　2874-2883　2014年11月

    DOI： 10.1007/s00167-013-2659-9 　

    ISSN：0942-2056

    eISSN：1433-7347

  43. Joint Immobilization Induced Hypoxic and Inflammatory Conditions in Rat Knee Joints

    Yutaka Yabe, Yoshihiro Hagiwara, Hideaki Suda, Akira Ando, Yoshito Onoda, Masahiro Tsuchiya, Kouki Hatori, Eiji Itoi

    CONNECTIVE TISSUE RESEARCH　54　(3)　210-217　2013年

    DOI： 10.3109/03008207.2013.786056 　

    ISSN：0300-8207

  44. Natural history of intradural-extramedullary spinal cord tumors

    Hiroshi Ozawa, Yoshito Onoda, Toshimi Aizawa, Takeshi Nakamura, Tomoaki Koakutsu, Eiji Itoi

    ACTA NEUROLOGICA BELGICA　112　(3)　265-270　2012年9月

    DOI： 10.1007/s13760-012-0048-7 　

    ISSN：0300-9009

  45. Remobilization Does Not Restore Immobilization-Induced Adhesion of Capsule and Restricted Joint Motion in Rat Knee Joints

    Akira Ando, Hideaki Suda, Yoshihiro Hagiwara, Yoshito Onoda, Eiichi Chimoto, Eiji Itoi

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　227　(1)　13-22　2012年5月

    DOI： 10.1620/tjem.227.13 　

    ISSN：0040-8727

    eISSN：1349-3329

  46. Chondrogenic, inflammatory and fibrotic process in pathology of idiopathic frozen shoulders 査読有り

    Y. Hagiwara, A. Ando, Y. Onoda, T. Takemura, T. Minowa, N. Hanagata, M. Tsuchiya, Y. Saijo, E. Itoi

    Osteoarthritis and Cartilage　20　S247　2012年4月

    出版者・発行元： Elsevier {BV}

    DOI： 10.1016/j.joca.2012.02.411 　

  47. Coexistence of fibrotic and chondrogenic process in the capsule of idiopathic frozen shoulders 査読有り

    Y. Hagiwara, A. Ando, Y. Onoda, T. Takemura, T. Minowa, N. Hanagata, M. Tsuchiya, T. Watanabe, E. Chimoto, H. Suda, N. Takahashi, H. Sugaya, Y. Saijo, E. Itoi

    Osteoarthritis and Cartilage　20　(3)　241-249　2012年3月

    出版者・発行元： Elsevier {BV}

    DOI： 10.1016/j.joca.2011.12.008 　

    ISSN：1063-4584

    eISSN：1522-9653

  48. 強直性脊椎骨増殖症に発生した頸椎骨折の2例

    小川 真司, 伊勢福 修司, 高橋 康平, 小野田 祥人, 馬場 一慈

    Journal of Spine Research　3　(1)　46-49　2012年1月

    出版者・発行元： (一社)日本脊椎脊髄病学会

    ISSN：1884-7137

    eISSN：2435-1563

  49. Comparison of articular cartilage images assessed by high-frequency ultrasound microscope and scanning acoustic microscope

    Yoshihiro Hagiwara, Yoshifumi Saijo, Akira Ando, Yoshito Onoda, Hideaki Suda, Eiichi Chimoto, Kouki Hatori, Eiji Itoi

    INTERNATIONAL ORTHOPAEDICS　36　(1)　185-190　2012年1月

    DOI： 10.1007/s00264-011-1263-1 　

    ISSN：0341-2695

    eISSN：1432-5195

  50. Reversibility of Immobilization-Induced Articular Cartilage Degeneration after Remobilization in Rat Knee Joints

    Akira Ando, Hideaki Suda, Yoshihiro Hagiwara, Yoshito Onoda, Eiichi Chimoto, Yoshifumi Saijo, Eiji Itoi

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　224　(2)　77-85　2011年6月

    DOI： 10.1620/tjem.224.77 　

    ISSN：0040-8727

    eISSN：1349-3329

  51. 中下位頸椎損傷に対する後方ワイヤーないしケーブル固定

    小川 真司, 高橋 康平, 小野田 祥人, 伊勢福 修司, 石橋 賢太郎

    整形・災害外科　53　(7)　857-863　2010年6月

    出版者・発行元： 金原出版(株)

    ISSN：0387-4095

  52. Distribution of Type A and B Synoviocytes in the Adhesive and Shortened Synovial Membrane during Immobilization of the Knee Joint in Rats

    Akira Ando, Yoshihiro Hagiwara, Yoshito Onoda, Kouki Hatori, Hideaki Suda, Eiichi Chimoto, Eiji Itoi

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　221　(2)　161-168　2010年6月

    DOI： 10.1620/tjem.221.161 　

    ISSN：0040-8727

    eISSN：1349-3329

  53. Expression Patterns of Collagen Types I and III in the Capsule of a Rat Knee Contracture Model

    Yoshihiro Hagiwara, Akira Ando, Yoshito Onoda, Hiroyuki Matsui, Eiichi Chimoto, Hideaki Suda, Eiji Itoi

    JOURNAL OF ORTHOPAEDIC RESEARCH　28　(3)　315-321　2010年3月

    DOI： 10.1002/jor.20997 　

    ISSN：0736-0266

  54. Expression of Collagen Types I and II on Articular Cartilage in a Rat Knee Contracture Model

    Yoshihiro Hagiwara, Akira Ando, Eiichi Chimoto, Masahiro Tsuchiya, Ichiro Takahashi, Yasuyuki Sasano, Yoshito Onoda, Hideaki Suda, Eiji Itoi

    CONNECTIVE TISSUE RESEARCH　51　(1)　22-30　2010年

    DOI： 10.3109/03008200902859406 　

    ISSN：0300-8207

    eISSN：1607-8438

  55. 骨粗鬆症性椎体圧潰に対する前方除圧固定術

    小川 真司, 岩井 和夫, 安藤 晃, 小野田 祥人, 高橋 康平

    東北整形災害外科学会雑誌　53　(1)　1-6　2009年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN：1348-8694

  56. Increased Expression of Metalloproteinase-8 and-13 on Articular Cartilage in a Rat Immobilized Knee Model

    Akira Ando, Yoshihiro Hagiwara, Masahiro Tsuchiya, Yoshito Onoda, Hideaki Suda, Eiichi Chimoto, Eiji Itoi

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　217　(4)　271-278　2009年4月

    DOI： 10.1620/tjem.217.271 　

    ISSN：0040-8727

    eISSN：1349-3329

  57. Ultrasonic intensity microscopy for imaging of living cells

    Yoshihiro Hagiwara, Yoshifumi Saijo, Akira Ando, Eiichi Chimoto, Hideaki Suda, Yoshito Onoda, Eiji Itoi

    ULTRASONICS　49　(3)　386-388　2009年3月

    DOI： 10.1016/j.ultras.2008.10.013 　

    ISSN：0041-624X

    eISSN：1874-9968

  58. Intra-articular injection of hyaluronan diminishes loss of chondrocytes in a rat immobilized-knee model

    Akira Ando, Yoshihiro Hagiwara, Eiichi Chimoto, Kouki Hatori, Yoshito Onoda, Eiji Itoi

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　215　(4)　321-331　2008年8月

    DOI： 10.1620/tjem.215.321 　

    ISSN：0040-8727

    eISSN：1349-3329

  59. 上腕骨近位端骨折における保存療法の経験 下垂位での早期運動療法の効果

    佐藤 絢子, 小野田 祥人, 馬目 芳具

    東北理学療法学　(19)　39-43　2007年3月

    出版者・発行元： 日本理学療法士協会-東北ブロック協議会

    ISSN：0915-2180

    eISSN：2189-5686

︎全件表示 ︎最初の5件までを表示

MISC 73

  1. Spinopelvic-hip harmonyとHRQOLの関連性の検討 PI-LLとの比較

    藤田 涼, 高橋 康平, 石川 圭佑, 大野木 孝嘉, 秋 貴史, 馬場 一慈, 八幡 健一郎, 小野田 祥人, 森 優, 橋本 功, 相澤 俊峰

    日本整形外科学会雑誌　100　(3)　S1283-S1283　2026年3月

    出版者・発行元： (公社)日本整形外科学会

    ISSN： 0021-5325

    eISSN： 2758-7479

  2. 頸髄損傷患者に対して、救急医による一貫した全身管理により、合併症を克服して最善の転帰を達成し得る

    勝田 賢, 小野田 祥人, 工藤 大介

    日本救急医学会雑誌　36　(11)　989-989　2025年11月

    出版者・発行元： (一社)日本救急医学会

    ISSN： 0915-924X

    eISSN： 1883-3772

  3. 胸椎後縦靱帯骨化症における術後麻痺増悪に関連する因子の検討 後方除圧固定術vs後方進入前方除圧術

    大野木 孝嘉, 高橋 康平, 日下部 詢弥, 橋本 功, 八幡 健一郎, 小野田 祥人, 佐藤 雄紀, 菅野 晴夫, 小澤 浩司, 相澤 俊峰

    東日本整形災害外科学会雑誌　37　(3)　305-305　2025年8月

    出版者・発行元： 東日本整形災害外科学会

    ISSN： 1342-7784

    eISSN： 2433-569X

  4. C4・C5に連続するfloating lateral mass骨折に対し後方固定術を行った一例

    村上 大史, 舘田 聡, 安倍 美加, 小出 将志, 萱場 祐樹, 高橋 諒, 亀田 敦也, 小野田 祥人

    東日本整形災害外科学会雑誌　37　(3)　358-358　2025年8月

    出版者・発行元： 東日本整形災害外科学会

    ISSN： 1342-7784

    eISSN： 2433-569X

  5. 外傷性頸髄損傷後に神経症状の悪化を認めSubacute Progressive Ascending Myelopathyと診断した一例

    亀山 恒, 小野田 祥人, 藤田 涼, 勝田 賢, 鈴木 晃輝, 工藤 大介

    東北救急医学会総会・学術集会プログラム・抄録集　39回　82-82　2025年8月

    出版者・発行元： 東北救急医学会

  6. 頸椎脱臼の治療 急性期手術を行わない施設において何をすべきか?

    小川 真司, 小圷 知明, 小野田 祥人, 関口 玲, 千葉 知規

    骨折　47　(Suppl.)　S179-S179　2025年6月

    出版者・発行元： (一社)日本整形外傷学会

    ISSN： 0287-2285

    eISSN： 2434-6055

  7. 骨粗鬆症患者における腰痛と脊柱・骨盤・下肢アライメントの相互関係の検討

    藤田 涼, 高橋 康平, 大野木 孝嘉, 八幡 健一郎, 小野田 祥人, 森 優, 橋本 功, 相澤 俊峰

    日本整形外科学会雑誌　99　(3)　S745-S745　2025年3月

    出版者・発行元： (公社)日本整形外科学会

    ISSN： 0021-5325

    eISSN： 2758-7479

  8. PFA-(PI-LL)は脊椎と股関節の矢状面アライメントを一元的に評価しうる Spinopelvic-hip mismatchという新しい指標の提案

    藤田 涼, 高橋 康平, 石川 圭佑, 大野木 孝嘉, 秋 貴史, 馬場 一慈, 八幡 健一郎, 小野田 祥人, 橋本 功, 相澤 俊峰

    日本整形外科学会雑誌　99　(3)　S1150-S1150　2025年3月

    出版者・発行元： (公社)日本整形外科学会

    ISSN： 0021-5325

    eISSN： 2758-7479

  9. 脊柱変形矯正術後の体幹前傾遺残に影響する因子の検討

    高橋 康平, 橋本 功, 八幡 健一郎, 大野木 孝嘉, 小野田 祥人, 中村 豪, 半田 恭一, 菅野 晴夫, 小澤 浩司, 田中 靖久, 相澤 俊峰

    日本整形外科学会雑誌　99　(3)　S1153-S1153　2025年3月

    出版者・発行元： (公社)日本整形外科学会

    ISSN： 0021-5325

    eISSN： 2758-7479

  10. 非定型大腿骨骨折の予防的髄内釘固定の際に外側皮質骨肥厚部の粉砕を行った3例

    安山 晃弘, 菅谷 岳広, 池田 起也, 宮坂 沙也加, 小野田 祥人, 久志本 成樹, 相澤 利峰

    骨折　46　(Suppl.)　S151-S151　2024年6月

    出版者・発行元： (一社)日本整形外傷学会

    ISSN： 0287-2285

    eISSN： 2434-6055

  11. 各県における外傷ユニット・センターのあり方/展望 宮城県における整形外傷ユニットの現状と展望

    小暮 敦史, 小野田 祥人, 菅谷 岳広, 大津 進, 関口 玲, 安部 美加, 舘田 聡, 小圷 知明, 齋藤 秀雄, 入江 太一, 伊勢福 修司, 千葉 知規, 相澤 俊峰

    東北整形災害外科学会雑誌　67　(1)　128-128　2024年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 1348-8694

  12. 母趾MTP関節とIP関節の関節固定術を同時に行った重度足部外傷の一例

    小暮 敦史, 菅谷 岳広, 小野田 祥人, 相澤 俊峰

    東北整形災害外科学会雑誌　67　(1)　152-152　2024年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 1348-8694

  13. 非骨傷性頸髄損傷に対する超早期手術 非骨傷性頸髄損傷の治療 超急性期手術を必須化しない理由

    小川 真司, 小圷 知明, 千葉 知規, 関口 玲, 小野田 祥人

    骨折　45　(Suppl.)　S106-S106　2023年6月

    出版者・発行元： (一社)日本整形外傷学会

    ISSN： 0287-2285

    eISSN： 2434-6055

  14. 脊椎手術の低侵襲化と術中・術後の合併症予防 頸椎外傷治療における頸椎椎弓根スクリュー経皮的刺入法の精度とナビゲーションシステムの恩恵

    小川 真司, 小圷 知明, 衛藤 俊光, 千葉 知規, 関口 玲, 小野田 祥人

    東北整形災害外科学会雑誌　66　(1)　131-131　2023年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 1348-8694

  15. 非定型大腿骨転子下骨折に対し外反骨切りを併用し髄内釘固定を行った1例

    石津 敦玄, 菅谷 岳広, 小暮 敦史, 小野田 祥人, 相澤 俊峰

    東北整形災害外科学会雑誌　66　(1)　175-175　2023年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 1348-8694

  16. 重度感染・外傷に対する切断術と段階的断端形成術

    高橋 秀介, 菅谷 岳広, 小暮 敦史, 小野田 祥人, 相澤 俊峰

    東北整形災害外科学会雑誌　66　(1)　179-180　2023年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 1348-8694

  17. 腱移行を要した短母指伸筋損傷の一例

    小暮 敦史, 菅谷 岳広, 小野田 祥人, 相澤 俊峰

    日本手外科学会雑誌　39　(6)　1034-1035　2023年4月

    出版者・発行元： (一社)日本手外科学会

    ISSN： 2185-4092

    eISSN： 2188-1820

  18. 肘外側尺側側副靱帯の尺骨付着部損傷により術後に後外側不安定性が残存したterrible triad injuryの一例

    小暮 敦史, 菅谷 岳広, 小野田 祥人, 相澤 俊峰

    日本肘関節学会雑誌　30　(1)　S363-S363　2023年2月

    出版者・発行元： 日本肘関節学会

    ISSN： 1349-7324

    eISSN： 2434-2262

  19. 硬膜内髄外腫瘍における神経鞘腫と髄膜腫のMRI鑑別アルゴリズムの有効性

    村上 大史, 半田 恭一, 大野木 孝嘉, 鈴木 学, 高橋 康平, 小野田 祥人, 矢部 裕, 橋本 功, 小澤 浩司, 相澤 俊峰

    東北整形災害外科学会雑誌　65　(1)　258-258　2022年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 1348-8694

  20. 「若手外傷医による地域の外傷治療・教育の特徴と今後の課題」 宮城県における整形外傷教育の展望

    小暮 敦史, 菅谷 岳広, 小野田 祥人, 久志本 成樹, 相澤 俊峰

    東北整形災害外科学会雑誌　65　(1)　170-170　2022年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 1348-8694

  21. 保存治療中に転位が増大し手術加療を要した骨盤輪骨折lateral compression type 1の一例

    小暮 敦史, 菅谷 岳広, 小野田 祥人, 相澤 俊峰

    東北整形災害外科学会雑誌　65　(1)　235-235　2022年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 1348-8694

  22. 透析患者における黄色靱帯肥厚の病態解析

    石川 圭佑, 矢部 裕, 大野木 孝嘉, 小野田 祥人, 萩原 嘉廣, 相澤 俊峰

    日本整形外科学会雑誌　96　(2)　S317-S317　2022年3月

    出版者・発行元： (公社)日本整形外科学会

    ISSN： 0021-5325

    eISSN： 2758-7479

  23. 高齢者に発生する頸椎・頸髄損傷と肥満・るい痩の関係 JASA多施設共同研究による1412例の後ろ向き解析

    橋本 功, 小野田 祥人, 加藤 仁志, 安藤 圭, 安部 哲哉, 渡邉 航太, 古矢 丈雄, 中嶋 秀明, 長谷川 智彦, 寺島 嘉紀, 相澤 俊峰

    日本整形外科学会雑誌　96　(3)　S570-S570　2022年3月

    出版者・発行元： (公社)日本整形外科学会

    ISSN： 0021-5325

    eISSN： 2758-7479

  24. プレセプシンは術後創傷感染症早期診断に有用なマーカーである

    小圷 知明, 小野田 祥人, 小川 真司, 衛藤 俊光, 相澤 俊峰

    日本整形外科学会雑誌　96　(3)　S935-S935　2022年3月

    出版者・発行元： (公社)日本整形外科学会

    ISSN： 0021-5325

    eISSN： 2758-7479

  25. 急性期頸椎頸髄損傷の治療 超早期(受傷後8時間以内)、早期(8-24時間)、待機(24時間以降)の手術時期が麻痺の改善と合併症予防に及ぼす効果

    小川 真司, 小圷 知明, 衛藤 俊光, 千葉 知規, 関口 玲, 小野田 祥人

    Journal of Spine Research　13　(3)　258-258　2022年3月

    出版者・発行元： (一社)日本脊椎脊髄病学会

    ISSN： 1884-7137

    eISSN： 2435-1563

  26. プレセプシンは脊椎手術後創傷感染症早期診断に有用なマーカーである

    小圷 知明, 小野田 祥人, 小川 真司, 衛藤 俊光, 相澤 俊峰

    Journal of Spine Research　13　(3)　647-647　2022年3月

    出版者・発行元： (一社)日本脊椎脊髄病学会

    ISSN： 1884-7137

    eISSN： 2435-1563

  27. 突然の背部痛と下肢麻痺を認めた維持血液透析患者の1例

    千葉 祐貴, 藤倉 恵美, 福士 泰夫, 小野田 祥人, 久志本 成樹, 宮崎 真理子

    臨床透析　37　(7)　701-708　2021年7月

    出版者・発行元： (株)日本メディカルセンター

    ISSN： 0910-5808

    eISSN： 2433-247X

  28. 胸腰椎緊急手術器械セットによる術前待機時間の短縮化

    小野田 祥人, 久志本 成樹, 矢部 裕, 橋本 功, 相澤 俊峰, 井樋 栄二, 菅野 晴夫

    東北整形災害外科学会雑誌　64　(1)　189-189　2021年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 1348-8694

  29. 整形外科重度外傷へのアプローチと外傷医育成 整形外傷教育の現状と課題 一般外傷から重度外傷まで

    小暮 敦史, 小野田 祥人, 菅谷 岳広, 井樋 栄二

    東北整形災害外科学会雑誌　64　(1)　125-125　2021年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 1348-8694

  30. 胸椎後縦靱帯骨化症に対する後方進入前方除圧術(大塚変法)の手術成績とCTによる除圧の検証

    高橋 康平, 相澤 俊峰, 橋本 功, 小野田 祥人, 半田 恭一, 大野木 孝嘉, 菅野 晴夫, 小澤 浩司

    Journal of Spine Research　12　(3)　96-96　2021年3月

    出版者・発行元： (一社)日本脊椎脊髄病学会

    ISSN： 1884-7137

    eISSN： 2435-1563

  31. 硬膜内髄外腫瘍における神経鞘腫と髄膜腫のMRI鑑別アルゴリズムの有効性

    村上 大史, 相澤 俊峰, 半田 恭一, 大野木 孝嘉, 鈴木 学, 高橋 康平, 小野田 祥人, 橋本 功, 小澤 浩司, 井樋 栄二

    Journal of Spine Research　12　(3)　433-433　2021年3月

    出版者・発行元： (一社)日本脊椎脊髄病学会

    ISSN： 1884-7137

    eISSN： 2435-1563

  32. 診療ガイドラインに基づいた化膿性脊椎炎に対する治療戦略

    小圷 知明, 小野田 祥人, 相澤 俊峰, 千葉 知規, 小川 真司

    Journal of Spine Research　12　(3)　475-475　2021年3月

    出版者・発行元： (一社)日本脊椎脊髄病学会

    ISSN： 1884-7137

    eISSN： 2435-1563

  33. ビタミンD欠乏を伴ったParoxysmal sympathetic hyperactivity随伴異所性骨化を呈した1例

    渡邉 万葉, 佐藤 武揚, 松村 隆志, 小野田 祥人, 大柳 琢, 星 陽介, 久志本 成樹

    日本集中治療医学会雑誌　27　(Suppl.)　672-672　2020年9月

    出版者・発行元： (一社)日本集中治療医学会

    ISSN： 1340-7988

    eISSN： 1882-966X

  34. 化膿性脊椎炎重症例に対する包括的治療戦略 敗血症診療ガイドラインの遵守と整形外科的治療介入

    小圷 知明, 小野田 祥人, 大柳 琢, 相澤 俊峰, 井樋 栄二

    Journal of Spine Research　11　(3)　166-166　2020年3月

    出版者・発行元： (一社)日本脊椎脊髄病学会

    ISSN： 1884-7137

    eISSN： 2435-1563

  35. 胸椎後縦靱帯骨化症に対する後方進入前方除圧術の手術成績

    相澤 俊峰, 橋本 功, 菅野 晴夫, 半田 恭一, 小野田 祥人, 井樋 栄二, 小澤 浩司

    Journal of Spine Research　11　(3)　217-217　2020年3月

    出版者・発行元： (一社)日本脊椎脊髄病学会

    ISSN： 1884-7137

    eISSN： 2435-1563

  36. ラット膝関節不動化モデルにおける関節血腫は軟骨変性への影響

    曽木 靖仁, 萩原 嘉廣, 矢部 裕, 小野田 祥人, 関口 拓矢, 板谷 信行, 吉田 新一郎, 矢野 利尚, 鈴木 一瑛, 井樋 栄二

    日本整形外科学会雑誌　93　(8)　S1933-S1933　2019年9月

    出版者・発行元： (公社)日本整形外科学会

    ISSN： 0021-5325

    eISSN： 2758-7479

  37. ラット膝関節不動化モデルにおける関節血腫は軟骨変性への影響

    曽木 靖仁, 萩原 嘉廣, 矢部 裕, 小野田 祥人, 関口 拓矢, 板谷 信行, 吉田 新一郎, 矢野 利尚, 鈴木 一瑛, 井樋 栄二

    日本整形外科学会雑誌　93　(8)　S1933-S1933　2019年9月

    出版者・発行元： (公社)日本整形外科学会

    ISSN： 0021-5325

  38. 自然縮小傾向を示した胸椎部砂時計腫の1例

    鈴木 学, 相澤 俊峰, 橋本 功, 菅野 晴夫, 小野田 祥人, 衛藤 俊光, 半田 恭一, 大野木 孝嘉, 井樋 栄二

    東日本整形災害外科学会雑誌　31　(3)　371-371　2019年8月

    出版者・発行元： 東日本整形災害外科学会

    ISSN： 1342-7784

    eISSN： 2433-569X

  39. 不安定型骨盤輪骨折に対するDual-SAI screwsを用いた整復固定術 Extended tab screwによるreduction technique

    小野田 祥人, 菅野 晴夫, 相澤 俊峰, 橋本 功, 大柳 琢, 久志本 成樹, 井樋 栄二

    東日本整形災害外科学会雑誌　31　(3)　435-435　2019年8月

    出版者・発行元： 東日本整形災害外科学会

    ISSN： 1342-7784

    eISSN： 2433-569X

  40. 脊椎・脊髄外科手術に関係した遠隔脳出血の発生頻度 11年間の前向き研究

    相澤 俊峰, 小澤 浩司, 菅野 晴夫, 橋本 功, 小野田 祥人, 松田 倫治, 井樋 栄二

    日本整形外科学会雑誌　93　(3)　S873-S873　2019年3月

    出版者・発行元： (公社)日本整形外科学会

    ISSN： 0021-5325

    eISSN： 2758-7479

  41. 除圧固定術後に麻痺が増悪した胸椎OPLLの検討

    相澤 俊峰, 衛藤 俊光, 菅野 晴夫, 小野田 祥人, 橋本 功, 半田 恭一, 小澤 浩司

    Journal of Spine Research　10　(3)　283-283　2019年3月

    出版者・発行元： (一社)日本脊椎脊髄病学会

    ISSN： 1884-7137

    eISSN： 2435-1563

  42. HA顆粒によるPPS固定の補強法 新鮮屍体脊椎を用いた生体力学的解析

    菅野 晴夫, 相澤 俊峰, 小野田 祥人, 松田 倫治, 井樋 栄二

    Journal of Spine Research　10　(3)　652-652　2019年3月

    出版者・発行元： (一社)日本脊椎脊髄病学会

    ISSN： 1884-7137

    eISSN： 2435-1563

  43. 当科における胸椎OPLLに対する手術成績の検討

    衛藤 俊光, 相澤 俊峰, 菅野 晴夫, 小野田 祥人, 松田 倫治, 半田 恭一, 鈴木 学, 大野木 孝嘉, 井樋 栄二

    Journal of Spine Research　10　(3)　689-689　2019年3月

    出版者・発行元： (一社)日本脊椎脊髄病学会

    ISSN： 1884-7137

    eISSN： 2435-1563

  44. 当科における胸椎OPLLに対する手術治療の検討

    衛藤 俊光, 相澤 俊峰, 菅野 晴夫, 小野田 祥人, 松田 倫治, 半田 恭一

    東日本整形災害外科学会雑誌　30　(3)　388-388　2018年8月

    出版者・発行元： 東日本整形災害外科学会

    ISSN： 1342-7784

    eISSN： 2433-569X

  45. 鎖骨骨幹部偽関節に対する治療

    安倍 美加, 伊勢福 修司, 小川 真司, 齊藤 秀雄, 千葉 知規, 小野田 祥人

    骨折　40　(Suppl.)　S362-S362　2018年7月

    出版者・発行元： (一社)日本整形外傷学会

    ISSN： 0287-2285

    eISSN： 2434-6055

  46. 頸椎損傷に対する受傷後24時間以内の早期手術の効果と限界

    小川 真司, 伊勢福 修司, 齊藤 秀雄, 安倍 美加, 千葉 知規, 小野田 祥人

    Journal of Spine Research　9　(3)　481-481　2018年3月

    出版者・発行元： (一社)日本脊椎脊髄病学会

    ISSN： 1884-7137

    eISSN： 2435-1563

  47. 整形外科外来リハビリテーションにおける地域連携の現状

    佐藤 守且, 星 杏奈, 野邉 翔平, 青山 多佳子, 須藤 美代子, 小野田 祥人

    竹田綜合病院医学雑誌　43　69-70　2017年11月

    出版者・発行元： (一財)竹田健康財団竹田綜合病院

    ISSN： 1347-0183

  48. Bosworth型足関節脱臼骨折の1例

    大野木 孝嘉, 園淵 和明, 小野田 祥人, 藤城 裕一, 樋口 和東, 中島 聡一, 山田 登, 本田 雅人

    東北整形災害外科学会雑誌　60　(1)　233-234　2017年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 1348-8694

  49. 内頸静脈穿刺手技により外傷性頸部神経根傷害が生じた1例

    芝崎 真人, 大野木 孝嘉, 小野田 祥人, 藤城 裕一, 樋口 和東, 中島 聡一, 山田 登, 本田 雅人

    東北整形災害外科学会雑誌　60　(1)　251-252　2017年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 1348-8694

  50. 鼡径部軟部腫瘍が疑われた異所性子宮内膜症の1例

    佐藤 俊一郎, 岩井 和夫, 鈴木 堅太郎, 小野田 祥人, 服部 弘之, 山田 登

    東北整形災害外科学会雑誌　58　(1)　183-183　2015年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 1348-8694

  51. JOINT HEMORRHAGE ACCELERATED JOINT CONTRACTURE IN IMMOBILIZED KNEE IN RATS

    Y. Onoda, Y. Hagiwara, A. Ando, E. Chimoto, H. Suda, K. Sonofuchi, E. Itoi

    OSTEOARTHRITIS AND CARTILAGE　20　S70-S71　2012年4月

    ISSN： 1063-4584

  52. IMMOBILIZATION INDUCED PROLONGED INFLAMMATORY CONDITIONS IN RAT KNEE CAPSULE

    A. Ando, H. Suda, Y. Hagiwara, Y. Onoda, E. Chimoto, E. Itoi

    OSTEOARTHRITIS AND CARTILAGE　20　S58-S58　2012年4月

    ISSN： 1063-4584

  53. COMPARISON OF NORMAL ARTICULAR CARTILAGE IMAGES ASSESSED BY HIGH FREQUENCY ULTRASOUND MICROSCOPE AND SCANNING ACOUSTIC MICROSCOPE

    Y. Hagiwara, Y. Saijo, A. Ando, Y. Onoda, H. Suda, E. Chimoto, K. Hatori, E. Itoi

    OSTEOARTHRITIS AND CARTILAGE　19　S183-S183　2011年9月

    ISSN： 1063-4584

    eISSN： 1522-9653

  54. INFLUENCE OF BLOOD INJECTION ON RANGE OF MOTION IN A RAT IMMOBILIZED KNEE

    Y. Onoda, Y. Hagiwara, E. Chimoto, A. Ando, H. Suda, K. Sonofuchi, E. Itoi

    OSTEOARTHRITIS AND CARTILAGE　19　S67-S68　2011年9月

    ISSN： 1063-4584

    eISSN： 1522-9653

  55. HYPOXIC CONDITIONS IN THE CAPSULE AFTER JOINT IMMOBILIZATION

    H. Suda, A. Ando, Y. Hagiwara, Y. Onoda, E. Chimoto, K. Sonofuchi, E. Itoi

    OSTEOARTHRITIS AND CARTILAGE　19　S68-S69　2011年9月

    ISSN： 1063-4584

    eISSN： 1522-9653

  56. EFFECT OF REMOBILIZATION ON IMMOBILIZATION-INDUCED JOINT CONTRACTURE IN RAT KNEE JOINTS

    A. Ando, H. Suda, Y. Hagiwara, Y. Onoda, E. Chimoto, E. Itoi

    OSTEOARTHRITIS AND CARTILAGE　19　S54-S55　2011年9月

    ISSN： 1063-4584

    eISSN： 1522-9653

  57. 強直性脊椎骨増殖症に発生した頸椎骨折の2例

    小川 真司, 高橋 康平, 伊勢福 修司, 小野田 祥人, 馬場 一慈

    東北整形災害外科学会雑誌　55　(1)　193-194　2011年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 1348-8694

  58. INCREASED CAPSULAR RESTRICTION AND STIFFNESS IN A RAT KNEE FLEXION CONTRACTURE MODEL

    Y. Onoda, Y. Hagiwara, E. Chimoto, A. Ando, H. Suda, Y. Saijyo, E. Itoi

    OSTEOARTHRITIS AND CARTILAGE　18　S210-S211　2010年10月

    ISSN： 1063-4584

  59. CAPSULAR CHANGES IN A RAT IMMOBILIZED KNEE MODEL

    Y. Hagiwara, A. Ando, Y. Onoda, E. Chimoto, K. Hatoii, H. Suda, E. Itoi

    OSTEOARTHRITIS AND CARTILAGE　18　S213-S214　2010年10月

    ISSN： 1063-4584

  60. REVERSIBILITY OF IMMOBILIZATION-INDUCED ARTICULAR CARTILAGE DEGENERATION AFTER REMOBILIZATION IN RAT KNEE JOINTS

    A. Ando, H. Suda, Y. Hagiwara, Y. Onoda, E. Chimoto, Y. Saijo, E. Itoi

    OSTEOARTHRITIS AND CARTILAGE　18　S92-S93　2010年10月

    ISSN： 1063-4584

  61. 中下位頸椎損傷に対する後方ワイヤーないしケーブル固定

    小川 真司, 小野田 祥人, 高橋 康平, 伊勢福 修司, 石橋 賢太郎

    東北整形災害外科学会雑誌　54　(1)　132-132　2010年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 1348-8694

  62. 超音波顕微鏡の培養細胞への応用

    萩原嘉廣, 西條芳文, 安藤晃, 千本英一, 小野田祥人, 須田英明, 井樋栄二

    日本整形外科学会雑誌　82　(8)　S1018-S1018　2008年8月25日

    出版者・発行元： (公社)日本整形外科学会

    ISSN： 0021-5325

    eISSN： 2758-7479

  63. ラット膝関節不動化モデルにおける軟骨変性の経時的変化

    安藤晃, 萩原嘉廣, 千本英一, 小野田祥人, 須田英明, 井樋栄二

    日本整形外科学会雑誌　82　(8)　S1206-S1206　2008年8月25日

    出版者・発行元： (公社)日本整形外科学会

    ISSN： 0021-5325

    eISSN： 2758-7479

  64. 大腿骨顆部冠状骨折5例の検討

    小野田 祥人, 岩井 和夫, 吉田 秀一, 小川 真司, 古田島 聡, 鈴木 和也, 高橋 康平

    骨折　29　(Suppl.)　S37-S37　2007年5月

    出版者・発行元： (一社)日本整形外傷学会

    ISSN： 0287-2285

    eISSN： 2434-6055

  65. 後外側回旋不安定を伴う肘関節脱臼新鮮例に対する靱帯修復術4例の検討

    安藤 晃, 岩井 和夫, 吉田 秀一, 小川 真司, 谷口 利江, 武田 宏史, 小野田 祥人

    東北整形災害外科学会雑誌　50　(1)　116-116　2006年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 1348-8694

  66. 半月板変性断裂に対する鏡視下半月板部分切除術の検討

    安藤 晃, 岩井 和夫, 吉田 秀一, 小川 真司, 谷口 利江, 武田 宏史, 小野田 祥人

    東北整形災害外科学会雑誌　50　(1)　118-118　2006年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 1348-8694

  67. TKA術後の慢性化膿性関節炎の一例 セメントスペーサーの利用法と二期的再置換のタイミングについて

    吉田 秀一, 武田 宏史, 小野田 祥人, 岩井 和夫, 小川 真司, 谷口 利江, 安藤 晃

    東北整形災害外科学会雑誌　50　(1)　120-120　2006年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 1348-8694

  68. 大腿骨頸部骨折に対するZweymueller型セメントレスステムのX線学的検討

    小野田 祥人, 吉田 秀一, 武田 宏史, 岩井 和夫, 谷口 利江, 小川 真司, 安藤 晃

    東北整形災害外科学会雑誌　50　(1)　126-126　2006年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 1348-8694

  69. 仙骨部の腫瘍性病変により下肢痛をきたした2例

    岡田 篤, 那須 孝邦, 安島 雄二, 小野田 祥人

    東北整形災害外科学会雑誌　49　(1)　147-147　2005年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 1348-8694

  70. 再発が疑われた術後肺血栓塞栓症の2例

    小野田 祥人, 那須 孝邦, 安島 雄二, 岡田 篤, 平 カヤノ

    東北整形災害外科学会雑誌　49　(1)　176-176　2005年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 1348-8694

  71. 踵骨骨折に対するプレート固定の治療成績

    安島 雄二, 那須 孝邦, 檜森 興, 小野田 祥人, 前田 慎吾

    東日本整形災害外科学会雑誌　16　(3)　371-371　2004年8月

    出版者・発行元： 東日本整形災害外科学会

    ISSN： 1342-7784

    eISSN： 2433-569X

  72. 両側大腿骨頸部骨折例の検討

    小野田 祥人, 那須 孝邦, 安島 雄二, 安倍 美加, 日下部 明, 前田 慎吾

    東北整形災害外科学会雑誌　48　(1)　103-103　2004年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 1348-8694

  73. 椎体圧迫骨折後遅発性に両側椎間孔障害をきたした1例

    安倍 美加, 那須 孝邦, 安島 雄二, 小野田 祥人, 日下部 明

    東北整形災害外科紀要　47　(1)　132-133　2003年6月

    出版者・発行元： 東北整形災害外科学会

    ISSN： 0040-8751

︎全件表示 ︎最初の5件までを表示

共同研究・競争的資金等の研究課題 1

  1. 微小還流を用いた筋・筋膜性疼痛の組織液採取と組成解析

    小野田 祥人

    提供機関：Japan Society for the Promotion of Science

    制度名：Grants-in-Aid for Scientific Research

    研究種目：Grant-in-Aid for Early-Career Scientists

    研究機関：Tohoku University

    2018年4月1日 ～ 2021年3月31日

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    筋・筋膜痛症候群（myofascial pain syndrome : MPS）は、様々な疼痛症状が慢性的に出現する慢性疼痛疾患である。いわゆる肩こりや腰痛も、MPSに関連した症状であることも多く、その発生頻度は高いが、病態は未だ不明な点が多く、有効な治療法は確立されていない。本研究は、筋・筋膜痛において、局所の代謝サイクルの変化が、痛みの原因とされる組織の酸性環境の構築へどのように影響しているのかを明らかにするものである。 本研究では、健常成人およびMPS患者を対象に、未承認機器である微小還流という技術を用いて行うため、特定臨床研究に該当する。倫理申請を行っており、倫理委員会の承認をまちつつ、動物を用いた予備実験を進めている。予備実験の結果では、過剰な収縮により痛みの生じた筋肉では、核酸代謝が亢進し、代謝産物である尿酸やキサンチンの上昇を確認している。一方で、痛みに関連するとされているATPは減少していることが分かった。ATPはエネルギー代謝に大きくかかわる物質でもあるため、過剰な筋収縮によって消費され、減少したものと推察された。これまで、筋肉痛の原因の一つとして報告されていたATPの減少傾向が確認され、間接的にではあるが、疼痛物質の発現量だけではなく、それ以外の因子が痛みの発現に関与している可能性が考えられた。尿酸の増加による環境の酸性化は、その因子の一つである可能性が高いと考えられた。