研究者詳細

顔写真

オオタ　シヨウコ
太田　祥子
Shoko Ota
所属
病院　感覚器・理学診療科　高次脳機能障害科
職名
助教
学位

  • 博士（障害科学）

e-Rad 研究者番号
70963833

論文 32

  1. Posterior Disconnection Syndrome in Early-Stage Adult-Onset Cerebral Adrenoleukodystrophy

    Kazuto Katsuse, Takashi Matsukawa, Yumiko Nakamura, Kazuo Kakinuma, Shoko Ota, Ryo Hara, Saki Nakashima, Kaoru Ito, Yutaro Nakamori, Toshiyuki Kakumoto, Masashi Hamada, Shigenori Kanno, Kyoko Suzuki, Tatsushi Toda

    Annals of Clinical and Translational Neurology　2026年

    出版者・発行元： Wiley

    ISSN：2328-9503

    eISSN：2328-9503

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    ABSTRACT Adult‐onset cerebral adrenoleukodystrophy is potentially treatable but often difficult to recognize before advanced cerebral involvement. Herein, we describe three men with early‐stage disease who initially presented with subtle visual complaints rather than subcortical dementia. Targeted neuropsychological testing revealed higher‐order visual dysfunction and posterior interhemispheric disconnection signs, including visual‐field‐dependent reading or naming deficits and dichotic listening abnormalities. Diffusion tensor imaging showed preferential involvement of posterior callosal and visual stream‐related white‐matter pathways. These findings define a posterior disconnection phenotype of adult‐onset cerebral adrenoleukodystrophy and provide a clinically useful framework for early recognition and timely therapeutic consideration of this treatable leukodystrophy.

  2. Anomic primary progressive aphasia with kanji-predominant dyslexia and dysgraphia

    Shoko Ota, Kazuo Kakinuma, Kazuto Katsuse, Nobuko Kawakami, Ayumi Morita, Ai Kawamura, Nanayo Ogawa, Chifumi Iseki, Shigenori Kanno, Minoru Matsuda, Kyoko Suzuki

    Cortex　2026年

    出版者・発行元： Elsevier BV

    ISSN：0010-9452

  3. Environmental sound processing in primary progressive aphasia: behavioral deficits and their neural correlates

    Nobuko Kawakami, Shoko Ota, Nanayo Ogawa, Kazuo Kakinuma, Kazuto Katsuse, Shiho Matsubara, Keisuke Morihara, Erena Kobayashi, Ai Kawamura, Hana Kikuchi, Chifumi Iseki, Kentaro Takanami, Shigenori Kanno, Kyoko Suzuki

    Brain and Cognition　2026年

    出版者・発行元： Elsevier BV

    ISSN：0278-2626

  4. Eating behaviour profiles across the frontotemporal dementia spectrum

    Yuki Sato, Hitomi Hayashi, Kazuo Kakinuma, Chifumi Iseki, Shoko Ota, Kazuto Katsuse, Shiho Matsubara, Nobuko Kawakami, Shigenori Kanno, Keisuke Morihara, Yoshiyuki Nishio, Kyoko Suzuki

    Journal of Neuropsychology　2026年

    出版者・発行元： Wiley

    ISSN：1748-6645

    eISSN：1748-6653

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    Abstract Altered eating behaviours are a hallmark of behavioural variant frontotemporal dementia (bvFTD) but are less well characterised in progressive nonfluent aphasia (PNFA) and semantic dementia (SD). We investigated the frequency and onset of eating behaviour changes across the three subtypes. We retrospectively reviewed the data of 58 patients (14 bvFTD, 30 PNFA and 14 SD). The presence and onset of eating changes were assessed using the Neuropsychiatric Inventory and medical records. Eating behaviours were categorised into overeating, reduced food intake and food preference change. Primary outcomes were prevalence and incidence rates from the initial disease symptoms. A time‐to‐event analysis was used to compare the cumulative incidence of eating behaviour changes; cumulative incidence curves were estimated using the Kaplan–Meier method; and group differences were assessed using the log‐rank test. Although the prevalence of eating changes was the highest in bvFTD (85.7%), followed by PNFA (63.3%) and SD (57.1%), the differences were not statistically significant ( p  = .220). Incidence also did not differ significantly ( p  = .054). However, overeating was significantly more frequent in the bvFTD group than in the PNFA and SD groups ( p  = .011). Changes in appetite and eating behaviour are common across the frontotemporal dementia spectrum and are not limited to bvFTD. Although the overall prevalence is similar across subtypes, overeating is specifically observed in bvFTD, whereas reduced food intake and food preference changes occur non‐specifically.

  5. Clinical profile of idiopathic normal pressure hydrocephalus with reduced myocardial sympathetic nerve function

    Shiho Matsubara, Shigenori Kanno, Toru Baba, Yoshiyuki Nishio, Chifumi Iseki, Nobuko Kawakami, Kazuo Kakinuma, Hayato Odagiri, Shoko Ota, Keiko Endo, Kentaro Takanami, Shin-ichiro Osawa, Tomohiro Kawaguchi, Hidenori Endo, Kyoko Suzuki

    Parkinsonism & Related Disorders　2026年

    出版者・発行元： Elsevier BV

    ISSN：1353-8020

  6. 単音および短い単語のひらがな書字障害を呈した非流暢性 / 失文法型原発性進行性失語の1例

    川上暢子, 勝瀬一登, 森原啓介, 森田亜由美, 太田祥子, 川村藍, 柿沼一雄, 伊関千書, 菅野重範, 鈴木匡子

    高次脳機能研究　45　(4)　228-236　2025年12月

    出版者・発行元：

    DOI： 10.2496/hbfr.45.228 　

    ISSN：1348-4818

    eISSN：1880-6554

  7. Assessment of memory lateralization by posterior cerebral artery selective anesthesia and postoperative verbal memory decline

    Hana Kikuchi, Kazuo Kakinuma, Shin-Ichiro Osawa, Shoko Ota, Kazuto Katsuse, Kazushi Ukishiro, Kazutaka Jin, Shiho Sato, Shunji Mugikura, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

    Journal of Neurosurgery　2025年12月

    出版者・発行元： Journal of Neurosurgery Publishing Group (JNSPG)

    ISSN：0022-3085

    eISSN：1933-0693

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    OBJECTIVE The Wada test, an intracarotid amobarbital procedure, is the gold standard for preoperative evaluation of postoperative memory decline in patients with drug-resistant epilepsy. However, it has certain limitations including false negatives due to insufficient hippocampal inhibition and false positives due to extrahippocampal disorders such as aphasia. This study examined the utility of posterior cerebral artery (PCA) selective anesthesia for functional evaluation (SAFE) as an alternative approach to avoid aphasia and assessed its predictive value for postoperative verbal memory decline. METHODS The authors conducted a single-center retrospective study of patients with drug-resistant epilepsy between May 2018 and December 2023, who subsequently underwent PCA SAFE before anterior temporal lobe resection. The SAFE protocol includes comparable memory tasks before and immediately after anesthetic infusion. Preinfusion assessments established baseline memory function, whereas postinfusion assessments evaluated brain function under selective anesthesia. Patients were required to memorize 8 words, 8 pictures, and 5 figures. After the anesthetic effects subsided, recognition tasks were performed for all presented stimuli. The memory score was calculated by subtracting the number of recognized items encoded under anesthesia from the baseline. Word recognition represented verbal memory, whereas figure recognition represented visual memory. A memory score ≥ 2 points on the side of the epileptic focus or no difference between left and right PCA SAFE was classified as a high risk of postoperative memory decline. A decline of ≥ 15 points in postoperative memory scores on the Wechsler Memory Scale–Revised was defined as significant memory decline. RESULTS The authors included 11 patients (focus side: left in 8 patients and right in 3 patients). Five patients were classified as having a high risk and 6 as having a low risk for verbal memory decline. All 5 high-risk patients revealed significant postoperative verbal memory decline, whereas 5 of the 6 low-risk patients did not. The sensitivity was 83.3%, and the specificity was 100%. No patients had a significant decline in postoperative visual memory. CONCLUSIONS PCA SAFE was shown to predict postoperative verbal memory decline with high accuracy. This study highlights the utility of PCA SAFE in reducing aphasic interference in verbal memory, leading to a more accurate evaluation of surgical candidacy in patients with drug-resistant epilepsy.

  8. Lecanemab for posterior cortical atrophy: Two contrasting cases

    Kazuto Katsuse, Kazuo Kakinuma, Yoshiki Niimi, Chifumi Iseki, Nobuko Kawakami, Shoko Ota, Ai Kawamura, Nanayo Ogawa, Satoka Yano, Toshiyuki Kakumoto, Hidemasa Takao, Masashi Hamada, Shigenori Kanno, Tatsushi Toda, Kyoko Suzuki

    The Clinical Neuropsychologist　2025年11月

    出版者・発行元： Informa UK Limited

    ISSN：1385-4046

    eISSN：1744-4144

  9. Dysgraphia in Japanese patients with primary progressive aphasia

    Shoko Ota, Maki Suzuki, Akihiro Takasaki, Nobuko Kawakami, Keisuke Morihara, Kazuo Kakinuma, Shiho Matsubara, Kazuto Katsuse, Chifumi Iseki, Shigenori Kanno, Manabu Ikeda, Kyoko Suzuki

    Brain and Language　2025年10月

    出版者・発行元： Elsevier BV

    ISSN：0093-934X

  10. White matter lesions associated with the reemergence of grasp reflexes in patients with idiopathic normal pressure hydrocephalus

    Junyan Liu, Shigenori Kanno, Chifumi Iseki, Nobuko Kawakami, Kazuo Kakinuma, Kazuto Katsuse, Shiho Matsubara, Shoko Ota, Keiko Endo, Kentaro Takanami, Shin-ichiro Osawa, Tomohiro Kawaguchi, Hidenori Endo, Shunji Mugikura, Kyoko Suzuki

    Fluids and Barriers of the CNS　22　(1)　2025年10月

    出版者・発行元： Springer Science and Business Media LLC

    eISSN：2045-8118

  11. Retrospective interviews reveal unawareness of weakness following reversible hemispheric suppression: An exploratory study using selective anesthesia for functional evaluation

    Hiroaki Hosokawa, Kazuo Kakinuma, Shin-Ichiro Osawa, Hana Kikuchi, Kazuto Katsuse, Shoko Ota, Erena Kobayashi, Nobuko Kawakami, Marie Oyafuso, Kazushi Ukishiro, Kazutaka Jin, Makoto Ishida, Kuniyasu Niizuma, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

    Cortex　2025年9月

  12. Spatiotemporal dynamics of reading Kana (syllabograms) and Kanji (morphograms)

    Kazuto Katsuse, Kazuo Kakinuma, Shin-Ichiro Osawa, Shoko Ota, Hana Kikuchi, Ai Kawamura, Kazushi Ukishiro, Kazuyo Tanji, Nobuko Kawakami, Chifumi Iseki, Shigenori Kanno, Yuichiro Shirota, Masashi Hamada, Tatsushi Toda, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

    Neuroimage　2025年8月

  13. Visualization of functional and effective connectivity underlying auditory descriptive naming

    Yu Kitazawa, Kazuki Sakakura, Hiroshi Uda, Naoto Kuroda, Riyo Ueda, Ethan Firestone, Min-Hee Lee, Jeong-Won Jeong, Masaki Sonoda, Shin-Ichiro Osawa, Kazushi Ukishiro, Makoto Ishida, Kazuo Kakinuma, Shoko Ota, Yutaro Takayama, Keiya Iijima, Toshimune Kambara, Hidenori Endo, Kyoko Suzuki, Nobukazu Nakasato, Masaki Iwasaki, Eishi Asano

    Clin Neurophysiol　2025年7月

  14. Impact of aphasia on verbal memory: insights from the Selective Anesthesia for Functional Evaluation

    Hana Kikuchi, Shin-Ichiro Osawa, Kazuo Kakinuma, Shoko Ota, Kazuto Katsuse, Kazushi Ukishiro, Kazutaka Jin, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

    J Neurosurg　2025年6月

  15. Case of Pure Agraphia in Kana and Romaji Without Sensorimotor Deficits After a Small Infarct of the Posterior Limb of the Internal Capsule

    Kazuto Katsuse, Akatsuki Kubota, Kazuo Kakinuma, Shoko Ota, Shigenori Kanno, Toshiyuki Kakumoto, Yuichiro Shirota, Masashi Hamada, Tatsushi Toda, Kyoko Suzuki

    Neurology　104　(7)　2025年4月8日

    出版者・発行元： Ovid Technologies (Wolters Kluwer Health)

    DOI： 10.1212/wnl.0000000000210254 　

    ISSN：0028-3878

    eISSN：1526-632X

  16. Distinct cerebral perfusion patterns and linguistic profiles in Alzheimer’s disease-related primary progressive aphasia

    Kazuto Katsuse, Kazuo Kakinuma, Nobuko Kawakami, Shoko Ota, Nanayo Ogawa, Ai Kawamura, Chifumi Iseki, Masashi Hamada, Tatsushi Toda, Minoru Matsuda, Shigenori Kanno, Kyoko Suzuki

    Neurological Sciences　2025年3月24日

    出版者・発行元： Springer Science and Business Media LLC

    DOI： 10.1007/s10072-025-08100-2 　

    ISSN：1590-1874

    eISSN：1590-3478

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    Abstract Alzheimer’s disease (AD)-related primary progressive aphasia (PPA) exhibits considerable heterogeneity in clinical presentation and neuroimaging patterns. No studies have quantitatively assessed cerebral perfusion patterns or systematically evaluated the internal heterogeneity of linguistic and neuroimaging features in this population. This study aimed to investigate cerebral hypoperfusion patterns and elucidate their correlation with diverse linguistic features in patients with AD-related PPA using a data-driven approach. Eleven patients with AD-related PPA and 34 with non-AD-related PPA were categorized based on cerebrospinal fluid biomarkers, and their single-photon emission computed tomography (SPECT) data were analyzed. Cerebral hypoperfusion was assessed across 56 regions of interest (ROIs) covering the entire cerebral hemisphere. Sparse principal component (sPC) analysis was performed on the AD-related PPA group to identify distinct patterns of cerebral perfusion reduction and correlate these components with clinical assessments of linguistic abilities. AD-derived sPCs were identified, reflecting hypoperfusion patterns in the left temporoparietal, frontal, and temporal pole regions, corresponding to regions typically associated with logopenic, nonfluent, and semantic variants. In both AD-PPA and non-AD-PPA, the sPC corresponding to the anterior temporal region was associated with semantic comprehension deficits, whereas that corresponding to the frontal region was linked to nonfluent speech and Kana writing impairment. sPC-based hierarchical clustering revealed clusters corresponding to logopenic, nonfluent, and semantic variants, with the anomic subtype distinguished from logopenic PPA. AD-positive cases were distributed across these clusters, emphasizing AD-PPA heterogeneity. These findings suggested that AD-related PPA heterogeneity is reflected in distinct cerebral perfusion patterns, which correlate with varying linguistic deficits.

  17. Verbal Memory Localized in Non-language-dominant Hemisphere: Atypical Lateralization Revealed by Material-specific Memory Evaluation Using Super-selective Wada Test.

    Hana Kikuchi, Shin-Ichiro Osawa, Kazuo Kakinuma, Shoko Ota, Kazuto Katsuse, Kazushi Ukishiro, Kazutaka Jin, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

    NMC case report journal　12　65-71　2025年

    DOI： 10.2176/jns-nmc.2024-0217 　

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    Hippocampectomy is effective for drug-resistant mesial temporal lobe epilepsy with hippocampal sclerosis. However, multiple studies have reported high risks associated with hippocampectomy in patients with mesial temporal lobe epilepsy without hippocampal sclerosis on magnetic resonance imaging and in those with preserved memory function. Verbal memory and language functions are believed to coexist in the same hemisphere. We present a case of left mesial temporal lobe epilepsy with atypical memory function lateralization revealed by super-selective infusion of propofol to the intracranial artery (super-selective Wada test). A 24-year-old right-handed man with drug-resistant focal impaired awareness seizures was diagnosed with left mesial temporal lobe epilepsy without hippocampal sclerosis, but he showed preserved verbal intelligence quotient and memory, suggesting a high risk of severe memory decline after hippocampectomy. We performed super-selective Wada test to the posterior cerebral artery to assess the lateralization of verbal and visual memory separately, and to the middle cerebral artery to assess language function. The results revealed right-sided dominance for both verbal and visual memory, although the language was left-dominant. Hippocampectomy was performed and resulted in freedom from seizures. Memory assessments 1 year postoperatively showed no decline in all subtests. In patients with drug-resistant epilepsy exhibiting atypical neuropsychological profiles, the memory-dominant, and language-dominant hemispheres may not align; detailed evaluations of function lateralization are necessary for tailored treatment.

  18. The utility of customised tissue probability maps and templates for patients with idiopathic normal pressure hydrocephalus: a computational anatomy toolbox (CAT12) study. 国際誌

    Shigenori Kanno, Junyan Liu, Ai Kawamura, Shoko Ota, Nobuko Kawakami, Chifumi Iseki, Kazuo Kakinuma, Shiho Matsubara, Kazuto Katsuse, Kazushi Sato, Takashi Takeuchi, Yoshitaka Tanaka, Hiroyasu Kodama, Tatsuo Nagasaka, Masahiro Sai, Hayato Odagiri, Mioko Saito, Kentaro Takanami, Shunji Mugikura, Kyoko Suzuki

    Fluids and barriers of the CNS　21　(1)　108-108　2024年12月30日

    DOI： 10.1186/s12987-024-00611-y 　

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    BACKGROUND: Disproportionately enlarged subarachnoid space hydrocephalus (DESH) is one of the neuroradiological characteristics of idiopathic normal pressure hydrocephalus (iNPH), which makes statistical analyses of brain images difficult. This study aimed to develop and validate methods of accurate brain segmentation and spatial normalisation in patients with DESH by using the Computational Anatomy Toolbox (CAT12). METHODS: Two hundred ninety-eight iNPH patients with DESH and 25 healthy controls (HCs) who underwent cranial MRI were enrolled in this study. We selected the structural images of 169 patients to create customised tissue probability maps and diffeomorphic anatomical registration through exponentiated Lie algebra (DARTEL) templates for patients with DESH (DESH-TPM and DESH-Template). The structural images of 38 other patients were used to evaluate the validity of the DESH-TPM and DESH-Template. DESH-TPM and DESH-Template were created using the 114 well-segmented images after the segmentation processing of CAT12. In the validation study, we compared the accuracy of brain segmentation and spatial normalisation among three conditions: customised condition, applying DESH-TPM and DESH-Template to CAT12 and patient images; standard condition, applying the default setting of CAT12 to patient images; and reference condition, applying the default setting of CAT12 to HC images. RESULTS: In the validation study, we identified three error types during segmentation. (1) The proportions of misidentifying the dura and/or extradural structures as brain structures in the customised, standard, and reference conditions were 10.5%, 44.7%, and 13.6%, respectively; (2) the failure rates of white matter hypointensity (WMH) cancellation in the customised, standard, and reference conditions were 18.4%, 44.7%, and 0%, respectively; and (3) the proportions of cerebrospinal fluid (CSF)-image deficits in the customised, standard, and reference conditions were 97.4%, 84.2%, and 28%, respectively. The spatial normalisation accuracy of grey and white matter images in the customised condition was the highest among the three conditions, especially in terms of superior convexity. CONCLUSIONS: Applying the combination of the DESH-TPM and DESH-Template to CAT12 could improve the accuracy of grey and white matter segmentation and spatial normalisation in patients with DESH. However, this combination could not improve the CSF segmentation accuracy. Another approach is needed to overcome this challenge.

  19. Oral applause sign in progressive supranuclear palsy. 国際誌

    Kazuto Katsuse, Kazuo Kakinuma, Nobuko Kawakami, Shoko Ota, Ai Kawamura, Nanayo Ogawa, Chifumi Iseki, Masashi Hamada, Tatsushi Toda, Shigenori Kanno, Minoru Matsuda, Kyoko Suzuki

    Cortex　2024年12月27日

    DOI： 10.1016/j.cortex.2024.11.021 　

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    The applause sign (AS) is a recognized phenomenon observed in progressive supranuclear palsy (PSP) and other neurological conditions where individuals produce over three claps following a request to clap only thrice after a demonstration. In this study, we introduced a novel linguistic phenomenon termed the oral applause sign (OAS) associated with the AS. The OAS is characterized by increased repetition counts of Japanese repetitive onomatopoeic words, such as uttering "pata-pata-pata" instead of the expected "pata-pata." We identified this phenomenon in a patient with PSP exhibiting the AS and mild apraxia of speech. In addition, we developed the three-"pata" test, instructing the patient to say "pata" only thrice after demonstration without any semantic context, and reproduced the phenomenon of the additional increase of "pata" verbalization. The core feature of OAS is an inability to limit the count when repeating a small number of syllables continuously, similar to the inability to stop clapping. The shared features between the OAS and AS suggest potential overlapping mechanisms involving the dysfunction of the frontal lobe and subcortical structures and possibly, apraxia of speech. Considering that the OAS is triggered purely by repetition and unlikely to be affected by semantic content, it might be observable in Japanese and other languages. Longitudinal studies with larger cohorts across various neurodegenerative diseases and languages may elucidate the underlying mechanisms of the OAS and confirm its specificity to PSP, thus improving the generalizability and clinical relevance of the findings.

  20. 超選択的Wadaテストで言語優位半球と言語性記銘力の側方性不一致が示された側頭葉てんかんの1例

    柿沼一雄, 大沢伸一郎, 菊地花, 太田祥子, 勝瀬一登, 土屋真理夫, 浮城一司, 神一敬, 遠藤英徳, 中里信和, 鈴木匡子

    神経心理学　40　(3)　231-241　2024年9月

  21. A decade with anomic primary progressive aphasia

    Shoko Ota, Kazuo Kakinuma, Wataru Narita, Yoshiyuki Nishio, Nobuko Kawakami, Ayane Tamagake, Shigenori Kanno, Minoru Matsuda, Kyoko Suzuki

    eNeurologicalSci　35　100508-100508　2024年6月

    出版者・発行元： Elsevier BV

    DOI： 10.1016/j.ensci.2024.100508 　

    ISSN：2405-6502

  22. The grasp reflex in patients with idiopathic normal pressure hydrocephalus. 国際誌

    Junyan Liu, Shigenori Kanno, Chifumi Iseki, Nobuko Kawakami, Kazuo Kakinuma, Kazuto Katsuse, Shiho Matsubara, Shoko Ota, Keiko Endo, Kentaro Takanami, Shin-Ichiro Osawa, Tomohiro Kawaguchi, Hidenori Endo, Shunji Mugikura, Kyoko Suzuki

    Journal of neurology　2024年4月8日

    DOI： 10.1007/s00415-024-12341-0 　

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    OBJECTIVE: To investigate the prevalence and intensity of grasp reflexes and to examine changes in these reflexes after shunt surgery in patients with idiopathic normal pressure hydrocephalus (iNPH). METHODS: We enrolled 147 patients with probable iNPH. A standard procedure was used to determine the presence of grasp reflexes, and the intensity of these reflexes was assessed using a four-category classification. Clinical rating scales and their correlation with grasp reflexes were also evaluated. Grasp reflexes were reassessed in 72 patients 1 year after surgery. RESULTS: We found that approximately 50.3% of patients with iNPH exhibited a positive grasp reflex. Among these patients, 69% exhibited bilateral positivity, while the remaining patients showed unilateral positivity. Furthermore, the intensity of the grasp reflex was significantly correlated with the severity of gait and with cognitive, urinary, motor, and behavioural symptoms. Surgical interventions led to a reduction (41.7%) or maintenance (30.6%) of the reflex intensity in 72.3% of iNPH patients. The changes in reflex intensity showed significant positive correlations with changes in the number of steps of the Timed Up and Go test and Trail Making Test-A scores but not with changes in total scores on the iNPH Grading Scale. CONCLUSION: This retrospective study identified grasp reflexes as a highly prevalent phenomenon in patients with iNPH. These reflexes can assist in evaluating the severity of various symptoms, including cognitive, gait, urinary, motor and emotional symptoms.

  23. 発症早期から発話量低下と反響言語が顕著であった原発性非流暢性失語の1例

    小川 七世, 三田 晃裕, 鳥居 良太, 太田 祥子, 稲富 雄一郎, 森原 啓介, 山下 史匡, 菅野 重範, 鈴木 匡子

    臨床神経心理　34　17-25　2023年12月

    出版者・発行元： 東北神経心理懇話会

    ISSN：1344-0292

    eISSN：2758-0156

  24. Auditory phonological identification impairment in primary progressive aphasia

    Nobuko Kawakami, Shigenori Kanno, Shoko Ota, Keisuke Morihara, Nanayo Ogawa, Kyoko Suzuki

    Cortex　168　130-142　2023年

    出版者・発行元： Elsevier BV

    DOI： 10.1016/j.cortex.2023.08.007 　

    ISSN：0010-9452

  25. Baccofacial apraxia in primary progressive aphasia 国際誌

    Morihara K, Ota S, Kakinuma K, Kawakami N, Higashiyama Y, Kanno S, Tanaka F, Suzuki K

    Cortex　158　61-70　2023年

    DOI： 10.1016/j.cortex.2022.10.010 　

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    Buccofacial apraxia (BFA) is associated with nonfluent/agrammatic variant primary progressive aphasia (nfvPPA) as well as with the severity of apraxia of speech (AOS), a core symptom of nfvPPA. However, an association with agrammatism has not been established. The aim of this study was to examine the association between BFA and agrammatism in nfvPPA and to determine differences in atrophic regions in primary progressive aphasia (PPA) with and without BFA. Seventy-four patients with PPA were recruited, including 34, 15, 10, and 15 patients with nfvPPA, semantic variant PPA, logopenic variant PPA, and unclassified PPA, respectively. All patients underwent language examination and BFA evaluations. Voxel-based morphometry (VBM) was performed to determine whether atrophy of a specific lesion correlated with the presence of BFA. BFA was observed in 20 and 3 patients with nfvPPA and unclassified PPA, respectively. In a comparison of patients with nfvPPA with and without BFA, the BFA group showed significantly worse spontaneous speech and writing in the Western Aphasia Battery. The agrammatism ratio or the ratio of agrammatic errors to the total number of particles was higher in the BFA group; however, the severity of prosodic and phonetic components of AOS did not differ between the two groups. VBM showed that the severity of BFA correlated with atrophy of the opercular and triangular areas of the inferior frontal gyrus to a part of the left middle frontal gyrus. BFA has a different anatomical basis from AOS in patients with nfvPPA and that BFA is characterized by more anterior degeneration compared to that of AOS.

  26. プロソディー型原発性進行性発語失行の1例―apraxia of speech rating scale-3（ASRS-3）を用いた発語失行の評価―

    小川七世, 太田祥子, 長谷川康博, 八鍬央子, 菅野重範, 鈴木匡子

    言語聴覚研究　19　(4)　348-355　2022年12月

    出版者・発行元： 株式会社医学書院

    DOI： 10.11477/mf.6001200399 　

    ISSN：1349-5828

  27. Dyslexia and dysgraphia of primary progressive aphasia in Chinese: A systematic review

    Liu J, Ota S, Kawakami N, Kanno S, Suzuki K

    Front Neurol　13　1025660　2022年12月

  28. Determination of language areas in patients with epilepsy using the super-selective Wada test. 国際誌

    Kazuo Kakinuma, Shin-Ichiro Osawa, Hiroaki Hosokawa, Marie Oyafuso, Shoko Ota, Erena Kobayashi, Nobuko Kawakami, Kazushi Ukishiro, Kazutaka Jin, Makoto Ishida, Takafumi Sato, Mika Sakamoto, Kuniyasu Niizuma, Teiji Tominaga, Nobukazu Nakasato, Kyoko Suzuki

    IBRO neuroscience reports　13　156-163　2022年12月

    DOI： 10.1016/j.ibneur.2022.08.002 　

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    The Wada test is the gold standard for determining language-dominant hemisphere. However, the precise determination of language areas in each patient requires more invasive methods, such as electrocortical stimulation. Some studies have reported the use of anesthetic injection into selective cerebral arteries to predict postoperative function. To assess the function of the anterior and posterior language areas separately, we developed an advanced test named the "super-selective Wada test" (ssWada). The ssWada procedure is as follows: an endovascular neurosurgeon identifies the arterial branches of the middle cerebral artery (MCA) perfusing the anterior language area of the inferior frontal gyrus and the posterior language area of the posterior part of the superior temporal gyrus using angiography. Behavioral neurologists assess language symptoms before and after propofol administration using a microcatheter tip in the selected arterial branch. From 30 serial patients with epilepsy who underwent ssWada test at Tohoku University Hospital, we retrospectively reviewed patients in whom multiple areas in the bilateral MCA region was examined. Eight cases were identified in this study. All eight cases had been considered for resection of the area overlapping the classical language area. Three of the eight cases were left-dominant, and the within-hemisphere distribution was also considered typical. One case was determined to be left-dominant but atypical in the intra-hemispheric functional distribution. Two cases were right-dominant, and the intra-hemispheric functional distribution was considered a mirror image of the typical pattern. The remaining two cases were considered atypical, not only in terms of bilateral language function, but also in terms of anterior-posterior functional distribution. This case series demonstrates the potential utility of ssWada in revealing separate function of the anterior and posterior language areas. The ssWada allows simulation of local surgical brain resection and detailed investigation of language function, which potentially contributes to planning the resection area. Although indications for ssWada are quite limited, it could play a complementary role to noninvasive testing because it provides information related to resection using a different approach.

  29. 音の連結不良が顕著で音の歪みのない原発性進行性発語失行の1例

    小川七世, 太田祥子, 寺尾心一, 鈴木匡子

    神経心理学　37　(3)　212-218　2021年9月

  30. Echolalia in patients with primary progressive aphasia 国際誌

    Shoko Ota, Shigenori Kanno, Ayumi Morita, Wataru Narita, Nobuko Kawakami, Kazuo Kakinuma, Yumiko Saito, Erena Kobayashi, Toru Baba, Osamu Iizuka, Yoshiyuki Nishio, Minoru Matsuda, Hayato Odagiri, Keiko Endo, Kentaro Takanami, Etsuro Mori, Kyoko Suzuki

    European Journal of Neurology　28　(4)　1113-1122　2021年4月

    出版者・発行元： Wiley

    DOI： 10.1111/ene.14673 　

    ISSN：1351-5101

    eISSN：1468-1331

    詳細を見る 詳細を閉じる

    OBJECTIVE: This study aimed to examine echolalia and its related symptoms and brain lesions in primary progressive aphasia (PPA). METHODS: Forty-five patients with PPA were included: 19 nonfluent/agrammatic variant PPA (nfvPPA), 5 semantic variant PPA, 7 logopenic variant PPA, and 14 unclassified PPA patients. We detected echolalia in unstructured conversations. An evaluation of language function and the presence of parkinsonism, grasp reflex, imitation behaviour, and disinhibition were assessed. We also measured regional cerebral blood flow (rCBF) using single-photon emission computed tomography. RESULTS: Echolalia was observed in 12 nfvPPA and 2 unclassified PPA patients. All patients showed mitigated echolalia. We compared nfvPPA patients with echolalia (echolalia group) to those without echolalia (non-echolalia group). The median age of the echolalia group was significantly lower than that of the non-echolalia group, and the echolalia group showed a significantly worse auditory comprehension performance than the non-echolalia group. In contrast, the performance of repetition tasks was not different between the two groups. The prevalence of imitation behaviour in the echolalia group was significantly higher than that in the non-echolalia group. The rCBFs in the bilateral pre-supplementary motor area and bilateral middle cingulate cortex in the echolalia group were significantly lower than those in the non-echolalia group. CONCLUSIONS: These findings suggest that echolalia is characteristic of nfvPPA patients with impaired comprehension. Reduced inhibition of the medial frontal cortex with release activity of the anterior perisylvian area account for the emergence of echolalia.

  31. Sentence composition ability in two patients with non-fluent/agrammatic variant primary progressive aphasia

    Hiroyuki Watanabe, Minoru Matsuda, Shoko Ota, Toru Baba, Osamu Iizuka, Etsuro Mori

    Psychogeriatrics　18　(3)　231-234　2018年5月

    出版者・発行元： Wiley

    DOI： 10.1111/psyg.12311 　

    ISSN：1346-3500

  32. 進行性の語聾とforeign accent syndromeを呈した1例

    太田祥子, 松田実, 馬場徹, 遠藤佳子, 飯塚統, 森悦朗

    神経心理学　32　(4)　361-369　2016年12月

    出版者・発行元： 日本神経心理学会

    DOI： 10.20584/neuropsychology.32.4_361 　

    詳細を見る 詳細を閉じる

    <p>語聾とforeign accent syndromeを呈した神経変性疾患1例を報告した．症例は70歳の右利き女性．主訴は「ことばが聞き取りにくい」「呂律が回らない」であった．純音聴力は保たれていたが，語音聴力の低下が認められた．自発話は，時に音の誤りや助詞の省略・誤用が認められ，また外国人のような話し方に聞こえた．知的機能は保たれ，明らかな失語症は認められなかった．発話分析の結果，プロソディの異常が顕著で，アクセントの異常や音節の分離が示された．右優位にシルビウス裂の開大と前頭側頭葉の萎縮及び血流低下を認めており，右半球主体の両側性病変に由来すると考えられた．語聾と発話障害を呈する神経変性疾患の一群が存在することが示唆された．</p>

︎全件表示 ︎最初の5件までを表示

MISC 60

  1. 『覚醒下手術と神経心理学』選択的脳領域麻酔による機能マッピング

    大沢 伸一郎, 鈴木 匡子, 柿沼 一雄, 菊地 花, 浮城 一司, 石田 誠, 勝瀬 一登, 太田 祥子, 金森 政之, 下田 由輝, 新妻 邦泰, 神 一敬, 遠藤 英徳

    日本神経心理学会総会プログラム・予稿集　50回　88-88　2026年7月

    出版者・発行元： 日本神経心理学会

  2. 数字優位の純粋失読を呈した左後頭頭頂葉切除後の一例

    太田祥子, 勝瀬一登, 伊関千書, 森山さや香, 下田由輝, 金森政之, 柿沼一雄, 川上暢子, 菅野重範, 遠藤英徳, 松田実, 鈴木匡子

    神経心理学　41　(4)　235-235　2025年12月

  3. 難聴・視覚障害と認知症 認知症疾患における聴覚障害 原発性進行性失語を中心に

    川上 暢子, 太田 祥子, 柿沼 一雄, 伊関 千書, 菅野 重範

    Dementia Japan　39　(4)　572-572　2025年10月

  4. 自発話の障害が目立つ進行性核上性麻痺の一例

    太田祥子, 川上暢子, 森田亜由美, 柿沼一雄, 勝瀬一登, 小川七世, 菅野重範, 伊関千書, 松田実, 鈴木匡子

    言語聴覚研究　22　(3)　287-287　2025年9月

  5. 認知症に対する言語リハビリテーション

    太田祥子, 鈴木匡子

    Clinical Rehabilitation　34　(9)　924-928　2025年8月

  6. 1桁の掛け算に選択的な計算障害を示す原発性進行性失語症の症例

    勝瀬一登, 柿沼一雄, 森原啓介, 川上暢子, 菊地花, 川村藍, 太田祥子, 小川七世, 伊関千書, 菅野重範, 戸田達史, 鈴木匡子

    高次脳機能研究　45　(1)　24-25　2025年3月

  7. nfvPPAを用いた日本語および英語話者におけるAOSおよび失文法の脳イメージングプロファイル[Encore Presentation]【JST機械翻訳】

    HIGASHIYAMA Yuichi, HIGASHIYAMA Yuichi, LANDIN-ROMERO Ramon, MORIHARA Keisuke, OTA Shoko, KAWAKAMI Nobuko, ITO Takeshi, DOI Hiroshi, SUZUKI Kyoko, BALLARD Kirrie, PIGUET Olivier, TANAKA Fumiaki

    日本神経学会学術大会プログラム・抄録集　66th　2025年

  8. 選択的脳領域麻酔による新規機能マッピング法の確立

    大沢伸一郎, 鈴木匡子, 柿沼一雄, 菊地花, 浮城一司, 石田誠, 勝瀬一登, 太田祥子, 下田由輝, 新妻邦泰, 新妻邦泰, 新妻邦泰, 神一敬, 遠藤英徳

    臨床神経生理学(Web)　53　(5)　2025年

    ISSN： 2188-031X

  9. 選択的脳領域麻酔による新規脳機能マッピング法の確立

    大沢伸一郎, 鈴木匡子, 柿沼一雄, 菊地花, 浮城一司, 石田誠, 勝瀬一登, 太田祥子, 下田由輝, 金森政之, 新妻邦泰, 新妻邦泰, 新妻邦泰, 松本康史, 松本康史, 神一敬, 遠藤英徳

    てんかん研究　43　(2)　2025年

    ISSN： 0912-0890

  10. 失語症病型を含む前頭側頭型認知症の食行動異常の分析

    佐藤優樹, 林瞳美, 伊関千書, 勝瀬一登, 柿沼一雄, 太田祥子, 川上暢子, 菅野重範, 鈴木匡子

    日本神経学会学術大会プログラム・抄録集　66th　2025年

  11. 発話拍手徴候(oral applause sign)を示した7例の臨床的特徴

    勝瀬一登, 勝瀬一登, 柿沼一雄, 川上暢子, 太田祥子, 川村藍, 小川七世, 伊関千書, 濱田雅, 戸田達史, 菅野重範, 鈴木匡子

    日本神経学会学術大会プログラム・抄録集　66th　2025年

  12. 血管内治療手技の応用による多面的脳機能リスク評価

    大沢伸一郎, 鈴木匡子, 柿沼一雄, 菊地花, 浮城一司, 石田誠, 勝瀬一登, 金森政之, 下田由輝, 二宮敦彦, 太田祥子, 新妻邦泰, 新妻邦泰, 新妻邦泰, 松本康史, 松本康史, 中里信和, 遠藤英徳

    日本てんかん外科学会プログラム・抄録集　48th　2025年

  13. 超選択的Wadaテストによって言語優位半球と言語性記憶の優位半球が異なることが明らかになった内側側頭葉てんかんの1症例

    菊地 花, 大沢 伸一郎, 柿沼 一雄, 太田 祥子, 勝瀬 一登, 浮城 一司, 神 一敬, 遠藤 英徳, 中里 信和, 鈴木 匡子

    てんかん研究　42　(3)　665-666　2025年1月

  14. 半盲視野に人物の複雑幻視を生じた左後頭葉梗塞の一例

    柿沼一雄, 勝瀬一登, 松原史歩, 菊地花, 斎藤治仁, 太田祥子, 川上暢子, 伊関千書, 菅野重範, 鈴木匡子

    神経心理学　40　(4)　345-345　2024年12月

  15. 右大脳半球への超選択的Wadaテストによる半側空間無視の評価法の開発

    勝瀬一登, 柿沼一雄, 大沢伸一郎, 浮城一司, 菊地花, 川村藍, 斎藤治仁, 太田祥子, 伊関千書, 菅野重範, 戸田達史, 遠藤英徳, 中里信和, 鈴木匡子

    神経心理学　40　(4)　341-341　2024年12月

  16. Wadaテストにおける記憶スコアは言語機能領域への薬剤注入で低下しうる

    菊地 花, 大沢 伸一郎, 柿沼 一雄, 勝瀬 一登, 太田 祥子, 川村 藍, 劉 軍艶, 浮城 一司, 神 一敬, 遠藤 英徳, 中里 信和, 鈴木 匡子

    てんかん研究　42　(2)　522-522　2024年9月

  17. 超選択的Wadaテストによる脳領域別の言語機能推定

    柿沼 一雄, 大沢 伸一郎, 勝瀬 一登, 菊地 花, 太田 祥子, 川村 藍, 劉 軍艶, 浮城 一司, 神 一敬, 遠藤 英徳, 中里 信和, 鈴木 匡子

    てんかん研究　42　(2)　521-521　2024年9月

  18. 認知症の言語障害に対する治療・リハビリテーション

    太田祥子, 成田渉, 森田亜由美, 鈴木匡子

    老年精神医学雑誌　35　(9)　907-913　2024年9月

  19. 臨床神経心理士の未来：言語聴覚士の立場から

    太田祥子, 松田実, 鈴木匡子

    神経心理学　40　(3)　220-224　2024年9月

  20. 発語失行と構音障害

    太田祥子, 松田実, 鈴木匡子

    高次脳機能研究　44　(2)　156-160　2024年6月

  21. 超選択的Wadaテストにより非典型的側性化が明らかになった難治性てんかん患者の1例

    菊地花, 大沢伸一郎, 浮城一司, 柿沼一雄, 勝瀬一登, 太田祥子, 川村藍, 劉軍艶, 遠藤英徳, 中里信和, 鈴木匡子

    高次脳機能研究　44　(1)　79-79　2024年3月

  22. 超選択的Wadaテストで外側皮質言語機能と言語性記銘力の側方性不一致が示された側頭葉てんかんの一例

    柿沼一雄, 大沢伸一郎, 浮城一司, 土屋真理夫, 太田祥子, 遠藤英徳, 中里信和, 鈴木匡子

    高次脳機能研究　44　(1)　78-79　2024年3月

  23. 顕著な減弱型反響言語を特徴とする進行性非流暢性失語の2例

    佐々木文香, 小川七世, 太田祥子, 佐藤真実, 鈴木匡子, 寺尾心一

    高次脳機能研究　44　(1)　74-74　2024年3月

  24. 原発性進行性失語症における失文法の評価

    八鍬央子, 森原啓介, 川上暢子, 柿沼一雄, 松原史歩, 勝瀬一登, 勝瀬一登, 太田祥子, 小川七世, 川村藍, 菊地花, 菅野重範, 鈴木匡子

    高次脳機能研究　44　(1)　71-71　2024年3月

    ISSN： 1348-4818

  25. 運動感覚障害を伴わず，純粋失書・タイピング障害のみを示した左内包後脚梗塞の症例

    勝瀬 一登, 久保田 暁, 柿沼 一雄, 太田 祥子, 菅野 重範, 角元 利行, 代田 悠一郎, 濱田 雅, 戸田 達史, 鈴木 匡子

    高次脳機能研究　44　(1)　69-69　2024年3月

  26. Spatiotemporal neural dynamics in kanji vs. kana reading: An electroencephalography(ECoG) study

    臨床神経学　64　(Suppl.)　S237-S237　2024年

  27. 意図により悪化する着座障害を示した右頭頂後頭葉皮質下出血の一例

    勝瀬 一登, 柿沼 一雄, 森原 啓介, 松原 史歩, 川上 暢子, 川村 藍, 太田 祥子, 菅野 重範, 平山 和美, 鈴木 匡子

    臨床神経心理　34　27-27　2023年12月

  28. 原発性進行性失語における動詞呼称と名詞呼称の解離-脳血流低下部位との関連-

    勝瀬一登, 太田祥子, 柿沼一雄, 松原史歩, 川上暢子, 小川七世, 伊関千書, 戸田達史, 松田実, 菅野重範, 鈴木匡子

    神経心理学　39　(4)　317-317　2023年12月

  29. 原発性進行性失語における環境音認知および関連機能の検討

    川上暢子, 菅野重範, 太田祥子, 小川七世, 鈴木匡子

    Dementia Japan　37　(4)　2023年

    ISSN： 1342-646X

  30. アルツハイマー病理を背景とする原発性進行性失語の多様性評価と分類

    勝瀬一登, 柿沼一雄, 森原啓介, 松原史歩, 川上暢子, 小川七世, 太田祥子, 戸田達史, 松田実, 菅野重範, 鈴木匡子

    日本神経学会学術大会プログラム・抄録集　64th　2023年

  31. 原発性進行性失語の聴覚および聴覚的音韻処理機能障害と関連脳領域の検討

    川上暢子, 太田祥子, 森原啓介, 菅野重範, 鈴木匡子

    日本神経学会学術大会プログラム・抄録集　64th　2023年

  32. 発語失行と開鼻声を呈した進行性非流暢性失語の一例

    太田祥子, 川上暢子, 渡部聡, 松村邦也, 森田亜由美, 菅野重範, 森原啓介, 柿沼一雄, 松原史歩, 勝瀬一登, 松田実, 鈴木匡子

    言語聴覚研究　20　164-164　2023年

  33. 原発性進行性失語症における書字障害の検討 非流暢/失文法型と意味型との比較

    太田 祥子, 菅野 重範, 川上 暢子, 森原 啓介, 柿沼 一雄, 松原 史歩, 勝瀬 一登, 稲富 雄一郎, 鈴木 匡子

    高次脳機能研究　43　(1)　40-40　2023年

    出版者・発行元： (一社)日本高次脳機能障害学会

    ISSN： 1348-4818

    eISSN： 1880-6554

  34. 皮質電気刺激によって誘発されたキネトプシア:側頭葉てんかん症例における検討

    柿沼一雄, 大沢伸一郎, 浮城一司, 篠田元気, 細川大瑛, 親富祖まりえ, 太田祥子, 石田誠, 神一敬, 冨永悌二, 中里信和, 鈴木匡子

    日本神経化学会大会抄録集(Web)　65th　2022年

  35. 聴覚情報処理障害(APD)が疑われた成人2例の経験-APDは聴覚特異的な障害なのか?-

    菅野重範, 太田祥子, 親富祖まりえ, 佐々木志保, 川瀬哲明, 鈴木匡子

    臨床神経心理　33 (CD-ROM)　2022年

    ISSN： 1344-0292

  36. 長期に進行した失名辞失語を特徴とする前頭側頭葉変性症疑い例

    太田祥子, 成田渉, 西尾慶之, 松田実, 鈴木匡子

    臨床神経心理　32　23-23　2022年

  37. 原発性進行性失語症における口舌顔面失行の臨床学的特徴と責任病巣について

    森原啓介, 太田祥子, 柿沼一雄, 川上暢子, 東山雄一, 菅野重範, 田中章景, 鈴木匡子

    日本神経学会学術大会プログラム・抄録集　63rd　2022年

  38. 10年に渡り失語症を中心に緩徐に認知機能障害が進行したPPAの一例

    太田祥子, 柿沼一雄, 成田渉, 西尾慶之, 川上暢子, 玉懸綾音, 菅野重範, 森原啓介, 森原啓介, 松原史歩, 遠藤佳子, 松田実, 鈴木匡子

    神経心理学　38　(4)　287-287　2022年

  39. 言語症状に対する内観と失語型との対応－超選択的Wadaテストによる検討－

    柿沼一雄, 大沢伸一郎, 細川大瑛, 親富祖まりえ, 太田祥子, 浮城一司, 石田誠, 神一敬, 中里信和, 新妻邦泰, 冨永悌二, 鈴木匡子

    高次脳機能研究　42　(1)　97-97　2022年

    出版者・発行元： (一社)日本高次脳機能障害学会

    ISSN： 1348-4818

    eISSN： 1880-6554

  40. 超選択的Wada Testにおける片麻痺に対する病態失認の検討

    細川大瑛, 大沢伸一郎, 柿沼一雄, 太田祥子, 親富祖まりえ, 浮城一司, 石田誠, 神一敬, 中里信和, 新妻邦泰, 冨永悌二, 鈴木匡子

    高次脳機能研究　42　(1)　71-72　2022年

    出版者・発行元： (一社)日本高次脳機能障害学会

    ISSN： 1348-4818

    eISSN： 1880-6554

  41. 左頭頂葉切除後に非典型的言語分布を呈した脳腫瘍例：超選択的Wada testによる検討

    柿沼一雄, 大沢伸一郎, 下田由輝, 金森政之, 浮城一司, 太田祥子, 親富祖まりえ, 川村藍, 冨永悌二, 中里信和, 鈴木匡子

    神経心理学　37　324-324　2021年

  42. 経過ともに反響言語が顕著となった進行性非流暢性失語の2症例

    太田祥子, 森田亜由美, 成田渉, 川上暢子, 小林絵礼奈, 菅野重範, 鈴木匡子

    神経心理学　37　334-334　2021年

  43. プロソディー型原発性進行性発語失行（prosodic-PPAOS）の2例

    小川七世, 太田祥子, 長谷川康博, 八鍬央子, 寺尾心一, 山下匡史, 鈴木匡子

    言語聴覚研究　18　160-160　2021年

  44. 進行性非流暢性失語における反響言語の検討

    太田祥子, 菅野重範, 森田亜由美, 成田渉, 川上暢子, 柿沼一雄, 齋藤裕美子, 小林絵礼奈, 遠藤佳子, 鈴木匡子

    臨床神経心理　31　37-37　2021年

  45. 発語失行を伴う進行性非流暢性失語の臨床的特徴と脳機能低下部位

    太田祥子, 菅野重範, 森田亜由美, 成田渉, 川上暢子, 小林絵礼奈, 柿沼一雄, 遠藤佳子, 鈴木匡子

    神経心理学　36　232-232　2020年

  46. Echolalia in primary progressive aphasia

    Ota S, Kanno S, Morita A, Narita W, Kawakami N, Kakinuma K, Saito Y, Kobayashi E, Endo K, Suzuki K

    J Int Neuropsychol Soc　26　2020年

  47. 音の歪みがなく，音の連結不良が顕著な進行性発語失行の1例

    小川七世, 太田祥子, 寺尾心一, 鈴木匡子

    高次脳機能研究　40　60-60　2020年

  48. 混合型超皮質性失語から超皮質性運動失語に移行した1症例：呼称障害の検討を中心に

    太田祥子, 松田実, 篠田淳男

    神経心理学　34　320-320　2018年

  49. 失構音のない進行性非流暢性失語の一例

    成田渉, 松田実, 西尾慶之, 髙橋(太田)祥子, 渡部宏幸, 飯塚統, 馬場徹, 石原哲郎, 庄司裕美子, 森悦朗

    高次脳機能研究　37　34-34　2017年

  50. 声や音楽により情動を伴わず涙を流す意味性認知症症例

    飯塚統, 松田実, 髙橋(太田)祥子, 西尾慶之, 森悦朗

    神経心理学　32　376-376　2016年

  51. 左中心前回で特殊音節に選択的な書字障害を呈した一例

    髙橋(太田)祥子, 松田実, 遠藤佳子, 森悦朗

    神経心理学　32　370-370　2016年

  52. 進行性非流暢性失語の2例における文の構成能力に関する検討

    渡部宏幸, 松田実, 太田祥子, 馬場徹, 飯塚統, 西尾慶之, 森悦朗

    神経心理学　31　280-280　2015年

  53. 脳梗塞により失語症を呈したことを契機としてアルツハイマー病の診断に至った1例

    飯塚統, 松田実, 太田祥子, 森悦朗

    神経心理学　31　302-302　2015年

  54. 左右で質の異なる‘alien hand’を認めたcorticobasal degeneration(CBD)の1例

    成田渉, 西尾慶之, 泉香苗, 太田祥子, 平山和美, 飯塚統, 馬場徹, 石原哲郎, 松田実, 森悦朗

    臨床神経心理　26　25-25　2015年

  55. 左前頭葉梗塞による超皮質性感覚失語の一例

    太田祥子, 松田実, 飯塚統, 遠藤佳子, 森悦朗

    高次脳機能研究　34　21-22　2014年

  56. 進行性の語聾とforeign accent syndromeを呈した一例

    太田祥子, 松田実, 馬場徹, 遠藤佳子, 佐藤豊展, 松村邦也, 佐々木志保, 飯塚統, 森悦朗

    神経心理学　30　298-298　2014年

  57. 左側頭葉の著明な葉性萎縮を呈しながらlogopenic progressive aphasia様の言語症状を呈した1例

    成田渉, 飯塚統, 太田祥子, 松田実, 森悦朗

    神経心理学　29　292-292　2013年

  58. 左中心後回，縁上回の梗塞後に顕著な仮名の書字障害を呈した一例

    太田祥子, 遠藤佳子, 森悦朗, 森信芳

    神経心理学　29　303-303　2013年

  59. 大脳皮質基底核変性症(CBD) 一例の左手の行為に関する検討：どうしても右手を手伝ってしまう

    太田祥子, 菅野重範, 遠藤佳子, 西尾慶之, 五味幸寛, 森悦朗

    高次脳機能研究　33　99-99　2012年

  60. 小脳出血により前頭葉症状を呈した症例

    太田祥子, 森悦子, 山口友美, 柳澤瑶貴, 上村和也, 吉田太郎

    茨城県総合リハビリテーションケア学会誌　17　40-40　2010年

︎全件表示 ︎最初の5件までを表示

共同研究・競争的資金等の研究課題 2

  1. 日本語プロソディ障害の特性と神経基盤の解明

    太田 祥子

    2025年4月 ～ 2028年3月

  2. 認知症者における発話障害の評価と介入法に関する研究

    太田 祥子

    提供機関：Japan Society for the Promotion of Science

    制度名：Grants-in-Aid for Scientific Research

    研究種目：Grant-in-Aid for Research Activity Start-up

    研究機関：Tohoku University

    2022年8月31日 ～ 2024年3月31日

    詳細を見る 詳細を閉じる

    非流暢／失文法型原発性進行性失語症患者における発話運動障害の特徴を明らかにするために、聴覚印象による評価および音響分析による評価を実施した。聴覚印象による評価では、音の歪みや分離などの有無を評価する上でApraxia of Speech Rating Scale-3日本語版が1つの指標となる可能性が示唆された。音響分析による評価では、発語失行あり群において健常高齢者群よりも音の渡りが変動しやすく、ピッチアクセントの変化が乏しいという結果が示された。音の歪みの指標については、明らかな有意差を認めなかった。音響分析における指標の有用性については、今後さらに症例数を増やして検討する必要がある。