研究者詳細

顔写真

ササキ　ケンゴ
佐々木　健吾
Kengo Sasaki
所属
病院　外科　移植・再建・内視鏡外科
職名
助教
学位

  • 博士（医学）（東北大学）

経歴 13

  • 2023年4月 ～ 継続中
    東北大学病院　総合外科　助教

  • 2022年4月 ～ 2023年3月
    東北大学　高度教養教育・学生支援機構　助教

  • 2020年4月 ～ 2022年3月
    宮城刑務所　法務技官

  • 2019年10月 ～ 2020年3月
    岩手県立磐井病院　外科　医長

  • 2018年9月 ～ 2019年9月
    東北大学病院 総合外科

  • 2017年4月 ～ 2018年8月
    国立成育医療研究センター　移植外科　医員

  • 2015年11月 ～ 2017年3月
    国立成育医療研究センター　移植外科　フェロー

  • 2015年5月 ～ 2015年10月
    国立成育医療研究センター　移植外科　臨床研究員

  • 2014年4月 ～ 2015年4月
    国立成育医療研究センター　移植外科　レジデント

  • 2013年4月 ～ 2014年3月
    国立成育医療研究センター　移植外科　医員

  • 2012年4月 ～ 2013年3月
    東北大学大学院医学系研究科 先進外科学分野

  • 2010年4月 ～ 2012年3月
    秋田厚生連 平鹿総合病院　外科

  • 2008年4月 ～ 2010年3月
    秋田厚生連 平鹿総合病院　初期研修医

︎全件表示 ︎最初の5件までを表示

学歴 2

  • 東北大学　大学院医学系研究科

    2012年4月 ～ 2020年3月

  • 東北大学　医学部　医学科

    2002年4月 ～ 2008年3月

受賞 3

  1. 第六回 ビデオ賞 肝胆膵領域

    2018年5月　手術手技研究会　下大静脈浸潤を伴う再発肝芽腫にたいする下大静脈合併切除術の有効性

  2. Poster Presentation Award

    2016年10月　Asian Transplantation Week 2016　Single center experience of liver transplantation for mitochondrial respiratory chain disorder

  3. 優秀演題賞

    2015年5月　日本肝移植研究会　有機酸代謝異常症（メチルマロン酸血症, プロピオン酸血症）における生体肝移植

論文 70

  1. First-in-human clinical study of an embryonic stem cell product for urea cycle disorders. 国際誌

    Akihiro Umezawa, Akinari Fukuda, Reiko Horikawa, Hajime Uchida, Shin Enosawa, Yoshie Oishi, Naoko Nakamura, Kengo Sasaki, Yusuke Yanagi, Seiichi Shimizu, Toshimasa Nakao, Tasuku Kodama, Seisuke Sakamoto, Itaru Hayakawa, Saeko Akiyama, Noriaki Saku, Shoko Miyata, Kenta Ite, Palaksha Kanive Javaregowda, Masashi Toyoda, Hidenori Nonaka, Kazuaki Nakamura, Yoshikazu Ito, Yasuyuki Fukuhara, Osamu Miyazaki, Shunsuke Nosaka, Kazuhiko Nakabayashi, Chizuko Haga, Takako Yoshioka, Akira Masuda, Takashi Ohkura, Mayu Yamazaki-Inoue, Masakazu Machida, Rie Abutani-Sakamoto, Shoko Miyajima, Hidenori Akutsu, Yoichi Matsubara, Takashi Igarashi, Mureo Kasahara

    Stem cell research & therapy　16　(1)　120-120　2025年3月6日

    DOI： 10.1186/s13287-025-04162-3 　

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    BACKGROUND: This study assesses the safety and efficacy of hepatocyte-like cell (HLC) infusion therapy derived from human embryonic stem cells as bridging therapy for neonatal-onset urea cycle disorders (UCD). The research includes both preclinical and clinical evaluations to determine the feasibility of HLC infusion as a therapeutic option for safer pediatric liver transplantation. METHODS: Preclinical studies were conducted to validate the safety, biodistribution, and ammonia metabolism capabilities of HLCs using SCID mice models of UCD and extensive animal studies. In the clinical trial, five neonates with UCD received HLC infusions, intending to maintain metabolic stability and exceed a target weight of over 6 kg, which is considered necessary for safer liver transplantation. RESULTS: Preclinical studies demonstrated that HLCs successfully engrafted in the liver without adverse migration or tumor formation and effectively elongated survival. Clinically, all five neonates exceeded the target weight of 6 kg while maintaining metabolic stability and successfully bridging to transplantation. Post-transplantation follow-up revealed stable growth, metabolic control, and no neurological complications. CONCLUSIONS: The combined preclinical and clinical findings support HLC infusion as a viable bridge therapy for neonates with UCD, providing metabolic support to achieve safer weight thresholds for transplantation. While promising, careful monitoring remains essential, particularly for potential complications such as thrombus formation. TRIAL REGISTRATION: jRCT, jRCT1090220412. Registered on 27 February 2019, https://jrct.niph.go.jp/en-latest-detail/jRCT1090220412 (originally registered in JMACCT (JMA-IIA00412)).

  2. Bile Leakage after Liver Transplantation Owing to Stricture of Afferent Jejunal Loop Caused by an Intussusception Valve after Biliary Atresia Surgery: A Case Report.

    Hironobu Ito, Ryusuke Saito, Masaki Sato, Kyohei Kasuda, Naruhito Takido, Hiroyuki Ogasawara, Yoshihiro Shono, Muneyuki Matsumura, Ryuji Okubo, Kengo Sasaki, Atsushi Fujio, Hironori Kudo, Kazuaki Tokodai, Motoshi Wada, Michiaki Unno, Takashi Kamei

    Surgical case reports　11　(1)　2025年

    DOI： 10.70352/scrj.cr.25-0209 　

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    INTRODUCTION: Biliary atresia (BA) is a progressive cholangiopathy in neonates that results in biliary cirrhosis and liver failure without early intervention. Hepatic portoenterostomy (Kasai operation) remains the standard treatment, significantly improving survival rates. However, postoperative cholangitis is a major determinant of prognosis. To prevent cholangitis, various surgical modifications, including anti-reflux procedures such as intussusception anti-reflux valves (IAV), have been introduced. Although IAV has been widely adopted, some reports suggest that long-term survivors may develop afferent jejunal limb stenosis, leading to complications such as cholangitis and intestinal obstruction. Herein, we report a case of afferent jejunal loop stricture caused by IAV, which became symptomatic after liver transplantation (LT). CASE PRESENTATION: A 34-year-old man with a history of BA underwent Kasai operation with IAV and spur valve at 77 days of age. Despite experiencing recurrent cholangitis in adulthood, he survived with his native liver until developing liver cirrhosis and porto-pulmonary hypertension, necessitating deceased donor LT. Preoperative imaging revealed portal vein obstruction and dilated collateral circulation. During LT, severe adhesions and afferent limb dilation were observed, requiring a 30 cm resection of the jejunal limb. Postoperatively, he developed cholangitis, and imaging on postoperative day 16 revealed an anastomotic leak with an intra-abdominal abscess. Retrospectively, CT image before LT demonstrated the dilatation of the afferent limb and the stricture due to IAV was highly suspected. Double-balloon endoscopy confirmed complete afferent limb obstruction due to IAV-related stenosis. Surgical reconstruction with resection of the obstructed Roux-en-Y limb and creation of a new hepatojejunal anastomosis was performed. The patient recovered well and was discharged on postoperative day 45 without further complications. CONCLUSIONS: This case highlights the possibility for late-onset afferent jejunal stricture due to IAV in BA patients undergoing LT. The narrowing likely results from long-term fibrotic changes after 34 years from BA operation. Given the increasing number of BA survivors receiving LT, awareness of IAV-related complications is crucial. In cases with suspected afferent limb stenosis, preoperative assessment and consideration of jejunal limb resection during LT may help prevent postoperative complications.

  3. Anterior Mediastinal Lymph Node Metastasis of Intrahepatic Cholangiocarcinoma: A Case Report and Literature Review. 国際誌

    Tomoaki Tabata, Ryusuke Saito, Takeki Taniguchi, Kyohei Kasuda, Naruhito Takido, Hiroyuki Ogasawara, Yoshihiro Shono, Muneyuki Matsumura, Kengo Sasaki, Atsushi Fujio, Kazuaki Tokodai, Takanori Morikawa, Michiaki Unno, Takashi Kamei

    Surgical case reports　11　(1)　2025年

    DOI： 10.70352/scrj.cr.24-0025 　

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    INTRODUCTION: Intrahepatic cholangiocarcinoma (ICC) is the second most common liver malignant tumor with a poor prognosis. Lymph node (LN) metastasis is found in 15% of ICC at the time of initial diagnosis. However, the LN metastasis to the anterior mediastinum is extremely rare. Herein, we report a case of anterior mediastinal LN metastasis of ICC. CASE PRESENTATION: The patient is a 74-year-old man who had surgery for cervical esophageal cancer. During follow-up, a low-density hepatic tumor and swollen LNs in the anterior mediastinum were detected. The tumor of the liver was diagnosed as ICC by needle biopsy. Excisional biopsy of the LN was performed and the diagnosis was metastasis of ICC. Because the prognosis of the patient with ICC Stage IVB is poor, the patient received 8 courses of chemotherapy. Although the new lesion appeared next to the main tumor, these tumors were located in the left liver. In addition, it was difficult for the patient to continue the chemotherapy due to the renal dysfunction. Hepatectomy with lymphadenectomy was performed. The patient survives without recurrence for 9 months after surgery. This is the first report of anterior mediastinal metastasis of ICC without any other organ involvement. CONCLUSIONS: Metastasis to the anterior mediastinum of hepatic tumor can be explained by the system that lymphatic fluid running under the capsule of the liver drains to the anterior mediastinal LNs through the coronary ligament. Metastasis of ICC to mediastinal LNs can occur when the tumor is located at the surface of the liver. Excisional biopsy is effective in determining the accurate disease stage and the treatment strategy.

  4. The TEG 6s Global Hemostasis System is Useful for Coagulation Management in Simultaneous Pancreas and Kidney Transplantation: The First Two Cases. 国際誌

    Muneyuki Matsumura, Kengo Sasaki, Kazuaki Tokodai, Atsushi Fujio, Hiroyuki Ogasawara, Yoshihiro Shono, Michiaki Unno, Takashi Kamei

    Transplantation proceedings　56　(9)　2021-2026　2024年11月

    DOI： 10.1016/j.transproceed.2024.10.017 　

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    INTRODUCTION: Hypercoagulability-related graft thrombosis is the leading cause of graft failure after simultaneous pancreas-kidney transplantation (SPK). Addressing this issue is crucial to improve the outcomes of SPK recipients. Thromboelastography (TEG) has been used to assess the coagulation profiles of SPK recipients. Recently, a new-generation TEG device, the TEG 6s Global Hemostasis System, was introduced. This device offers advantages over TEG 5000, including less frequent calibration requirements, ease of use, and reduced sensitivity to movement. We hypothesized that TEG 6s would enhance coagulation management in SPK. METHODS: We report two cases of Asian female SPK recipients in whom TEG 6s was used to assess coagulation status at six preset times during and after surgery. RESULTS: Preoperatively, both patients exhibited hypercoagulability on TEG 6s. Postoperative intravenous heparin was administered, and the dose was titrated based on the TEG 6s results. Vascular thrombosis was not observed in either patient. Detailed TEG 6s and standard laboratory test results are reported. This pilot study demonstrates that TEG 6s monitoring can effectively assess coagulation status in SPK recipients, aiding in optimal coagulation management and reducing the risk of thrombotic complications leading to graft loss. The TEG 6s facilitated real-time and accurate coagulation assessment, allowing for tailored anticoagulant therapy. CONCLUSIONS: This is the first observational study to use TEG 6s in SPK recipients, indicating its potential benefits in improving patient outcomes. Further studies with larger sample sizes are warranted to validate these findings and establish comprehensive guidelines for using TEG 6s in SPK procedures.

  5. Practical Coagulation Management in Liver Transplantation through Point-of-Care Analysis using the TEG 6s Global Hemostasis System in Japan.

    Muneyuki Matsumura, Kengo Sasaki, Kazuaki Tokodai, Koji Miyazawa, Atsushi Fujio, Hiroyuki Ogasawara, Michiaki Unno, Takashi Kamei

    The Tohoku journal of experimental medicine　2024年9月5日

    DOI： 10.1620/tjem.2024.J087 　

  6. Small Intestinal Adenocarcinoma Arising at the Anastomotic Site after Kasai Operation for Biliary Atresia: A Case Report and Literature Review.

    Yuki Ishikawa, Ryusuke Saito, Keigo Murakami, Atsushi Fujio, Koji Miyazawa, Kengo Sasaki, Muneyuki Matsumura, Hiroaki Mitsugashira, Kazuki Degawa, Yoshinobu Kobayashi, Ryo Muto, Kazuaki Tokodai, Toru Furukawa, Michiaki Unno, Takashi Kamei

    The Tohoku journal of experimental medicine　261　(4)　267-272　2023年12月16日

    DOI： 10.1620/tjem.2023.J080 　

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    Biliary atresia is an obliterative cholangiopathy of unknown etiology. Hepatic portoenterostomy, in which obliterated extrahepatic bile ducts are resected and bile flow is restored, known as Kasai operation, is performed within 3 months after birth. While this operation enhances long-term survival of patients, the occurrence of primary malignant hepatic tumors has been increasing. We report a case of small intestinal adenocarcinoma arising at the anastomotic site after Kasai operation. A 49-year-old man, who underwent Kasai operation for biliary atresia when he was 2 months old, experienced rapidly progressive jaundice and liver dysfunction. Deceased-donor liver transplantation was performed for liver failure. Macroscopically, there was a white-yellow tumor located at the anastomotic site of hepatic portoenterostomy of the resected liver. Pathological examination revealed a well-differentiated adenocarcinoma with some Paneth cells in the neoplastic lesion. Immunohistochemically, the tumor cells were negative for cytokeratin 7 (CK7) but positive for cytokeratin 20 (CK20) and a homeobox domain-containing transcription factor (CDX2). Mucin expression in tumor cells was negative for mucin 1 (MUC1) and mucin 6 (MUC6) and positive for mucin 2 (MUC2) and mucin 5AC (MUC5AC). The pathological diagnosis was small intestinal adenocarcinoma originating from the jejunum. The patient was discharged 48 days after the operation. The patient had not experienced recurrence at 10 months after the operation. This is the first report of small intestinal adenocarcinoma arising at the anastomotic site after Kasai operation for biliary atresia. Special care should be taken for the patients after Kasai operation with acute progressive jaundice and liver dysfunction because there is a possibility of malignancy in their native liver.

  7. Tumor-to-Tumor Metastasis of Medullary Thyroid Carcinoma to Paraganglioma in a Multiple Endocrine Neoplasia Type 2B Patient: A Case Report and Literature Review.

    Naruhito Takido, Ryusuke Saito, Kaoru Okada, Norifumi Kanai, Yoshihiro Shono, Hiroaki Mitsugashira, Muneyuki Matsumura, Kengo Sasaki, Koji Miyazawa, Atsushi Fujio, Kazuaki Tokodai, Keigo Murakami, Hironobu Sasano, Michiaki Unno, Takanori Ishida, Takashi Kamei

    The Tohoku journal of experimental medicine　261　(1)　75-81　2023年9月20日

    DOI： 10.1620/tjem.2023.J058 　

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    Tumor-to-tumor metastasis is a rare phenomenon in which primary tumor cells metastasize to other tumors. Herein, we report an extremely rare case of tumor-to-tumor metastasis of medullary thyroid carcinoma to a paraganglioma in a patient with multiple endocrine neoplasia type 2B. Based on genetic examination, a 36-year-old woman was diagnosed with multiple endocrine neoplasia type 2B when she was 24 years old. She had a history of total thyroidectomy for medullary thyroid carcinoma and bilateral adrenalectomy for pheochromocytomas, which were performed when she was 15 years and 29 years old, respectively. Follow-up computed tomography demonstrated a retroperitoneal tumor of 30 mm in diameter beside the left kidney and a liver tumor of 16 mm in diameter located in segment 6. The retroperitoneal and liver tumors were surgically resected and examined by a pathologist. Histological examination revealed the classic Zellballen pattern in the retroperitoneal tumor, rendering the diagnosis of a paraganglioma recurrence. Inside the tumor, a white nodule positive for carcinoembryonic antigen, weakly positive for calcitonin, and negative for tyrosine hydroxylase, was identified and diagnosed as a metastatic medullary thyroid carcinoma with high malignant potential. The liver lesion was diagnosed as a metastasis of the medullary thyroid carcinoma. This is the first report of tumor-to-tumor metastasis of medullary thyroid carcinoma to paraganglioma in a patient with multiple endocrine neoplasia type 2B twenty years after total thyroidectomy.

  8. Clinical Significance of the Mac-2 Binding Protein Glycosylated Isomer as a Surrogate Marker of Graft Fibrosis After Pediatric Liver Transplantation. 国際誌

    Hiroki Yamana, Kazuaki Tokodai, Atsushi Fujio, Toshiaki Kashiwadate, Koji Miyazawa, Kengo Sasaki, Muneyuki Matsumura, Hiroaki Mitsugashira, Michiaki Unno, Takashi Kamei

    Transplantation proceedings　2023年4月30日

    DOI： 10.1016/j.transproceed.2023.03.053 　

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    BACKGROUND: After pediatric liver transplantation, liver fibrosis may occur during long-term follow-up. Noninvasive markers for assessing this liver fibrosis are desired. Mac-2 binding protein glycosylated isomer (M2BPGi) has recently been reported as a useful biomarker for liver fibrosis. However, its usefulness in the pediatric population is yet to be established. This study investigated the clinical significance of M2BPGi levels as a surrogate marker of graft fibrosis after pediatric liver transplantation. METHODS: We retrospectively identified 96 patients who underwent pediatric liver transplantation at our institution between 1991 and 2015. The association between M2BPGi levels and other fibrosis markers was analyzed in 60 patients in whom fibrosis markers were measured. The association between fibrosis marker levels and graft fibrosis was assessed in 42 patients who underwent biopsies between 2016 and 2022. RESULTS: The M2BPGi levels were statistically correlated with the hyaluronic acid and type-IV collagen levels. None of the fibrosis markers were significantly associated with liver graft fibrosis, although the levels of these markers were slightly higher in patients with severe liver fibrosis than in those with mild fibrosis. CONCLUSIONS: The M2BPGi levels had a limited ability to assess liver graft fibrosis after pediatric liver transplantation, similar to other fibrosis markers. Further studies with larger cohorts are required to validate these findings externally.

  9. Postreperfusion Syndrome Presenting as Posttransplant Portal Hypertension due to Prolonged Elevation of Pulmonary Vascular Resistance and the Role of Nitroglycerin in Diagnosis and Treatment: A Case Report of Budd-Chiari Syndrome.

    Takahiro Kawaji, Hiroaki Toyama, Norifumi Yoshida, Shoichiro Moteki, Ayaka Sasaki, Kengo Sasaki, Atsushi Fujio, Kazuaki Tokodai, Shigehito Miyagi, Masanori Yamauchi

    The Tohoku journal of experimental medicine　2022年12月8日

    DOI： 10.1620/tjem.2022.J105 　

  10. Probable posttransplant lymphoproliferative disorder after pediatric living donor liver transplantation: Is a biopsy still needed? 国際誌

    Muneyuki Matsumura, Shigehito Miyagi, Kazuaki Tokodai, Toshiaki Kashiwadate, Atsushi Fujio, Koji Miyazawa, Kengo Sasaki, Yoshikatsu Saito, Norifumi Kanai, Michiaki Unno, Takashi Kamei

    Clinical case reports　10　(11)　e6454　2022年11月

    DOI： 10.1002/ccr3.6454 　

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    Posttransplant lymphoproliferative disorder (PTLD) is a complication of solid organ transplantation and is associated with Epstein-Barr virus (EBV). Recently, EBV-related PTLD was defined as probable PTLD or proven PTLD. Probable PTLD involves significant lymphadenopathy, hepatosplenomegaly, or other end-organ manifestations, without a histological diagnosis, together with significant EBV DNAemia. Proven PTLD is the detection of EBV-encoded proteins in a tissue specimen, together with symptoms and/or signs originating from the affected organ. Probable PTLD after pediatric liver transplantation has not been well documented. Therefore, here, we aimed to describe cases of five pediatric patients with probable PTLD after liver transplantation, who were successfully treated with preemptive immunosuppression reduction with or without rituximab. All five patients (age range, 1-4 years; two girls and three boys) had EBV DNAemia. Three patients developed probable PTLD within 12 months of transplantation. Further, three patients had a significantly high EBV viral load, but the other two patients with lymphadenopathy and end-organ manifestation had a relatively low EBV viral load. Early onset pediatric PTLD with significant EBV DNAemia is almost universally EBV-related. Biopsy was not performed in any patient due to the relative inaccessibility of the lesion and young age of the patients. If the patient's symptoms are too mild, if excisional biopsy is too difficult to perform, or if the patient is too sick to undergo an invasive procedure, initiating preemptive treatment without a histological diagnosis could be the treatment option.

  11. A New Strategy of Liver Transplantation for Locally Advanced Unresectable Perihilar Cholangiocarcinoma Using Living Grafts With Simultaneous Resection of Recipients' Hepatic Artery and Portal Vein Without Neoadjuvant Radiation: A Case Report. 国際誌

    Shigehito Miyagi, Atsushi Fujio, Kei Nakagawa, Kazuaki Tokodai, Toshiaki Kashiwadate, Koji Miyazawa, Kengo Sasaki, Muneyuki Matsumura, Hiroyasu Nishimaki, Taizo Hibi, Takashi Kamei, Michiaki Unno

    Transplantation proceedings　2022年7月6日

    DOI： 10.1016/j.transproceed.2022.03.054 　

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    BACKGROUND: Perihilar cholangiocarcinoma (pCCA) is often unresectable, because it includes crucial blood vessels in portal area. The prognosis of locally advanced unresectable cholangiocarcinomas is extremely poor. Recently, there have been several reports of the prognosis improving drastically with transplantation and combined chemoradiation therapy. However, liver transplantation for pCCA has 2 big problems. The first is that pCCA is located at a lethal position and its progress is sometimes rapid; therefore, the optimal timing of transplantation is sometimes lost. The second is vascular complications associated with neoadjuvant radiation, especially in living donor liver transplantation (LDLT). To overcome these problems, we performed conversion surgery using LDLT with simultaneous resection of the hepatic artery and portal vein, instead of neoadjuvant radiation. Herein, we report our experience of interposition reconstruction. METHODS: A 31-year-old man with primary sclerosing cholangitis (PSC) was diagnosed with locally advanced unresectable pCCA. The patient underwent radical chemotherapy (gemcitabine/cisplatin/S-1) and avoided radiation because of PSC. After 6 months, positron emission tomography-computed tomography revealed no lymph node metastasis. There was no time to wait. We immediately performed LDLT with simultaneous resection of hepatic artery and portal vein, and microsurgical reconstruction using auto-vessel grafts. RESULTS: The recipient recovered and was discharged 31 days posttransplant. His liver function improved, and he has had no recurrence after LDLT. CONCLUSION: LDLT with neoadjuvant radiation is associated with high risk of vascular complications. In some cases, conversion surgery after radical chemotherapy using good timing LDLT without radiation may increase chances of transplantation for locally advanced pCCA.

  12. Long-term survival of an adult patient with undifferentiated embryonal sarcoma of the liver with multidisciplinary treatment: a case report and literature review. 国際誌

    Yukiko Kumata Endo, Atsushi Fujio, Keigo Murakami, Kengo Sasaki, Koji Miyazawa, Toshiaki Kashiwadate, Kazuaki Tokodai, Shigehito Miyagi, Fumiyoshi Fujishima, Michiaki Unno, Takashi Kamei

    Surgical case reports　8　(1)　85-85　2022年5月5日

    DOI： 10.1186/s40792-022-01436-3 　

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    BACKGROUND: Undifferentiated embryonal sarcoma of the liver (UESL) primarily occurs in children; it is rarely seen in adults and appears to have a poor prognosis. However, in recent years, some cases indicated that long-term survival was possible due to a combination of multiple surgeries, chemotherapy, and liver transplantation. CASE PRESENTATION: A 33-year-old female patient presented with a complaint of epigastric pain, for which she underwent a medical examination. Computed tomography (CT) and magnetic resonance imaging showed a cystic tumor in the right hepatic lobe, approximately 10 cm in size. During observation, the abdominal pain worsened, and a contrast-enhanced CT revealed that the tumor's peripheral solid components increased in size and volume, suggesting a malignant tumor threatening hepatic rupture. Subsequently, transcatheter arterial embolization of the anterior and posterior segmental branches of the hepatic artery was performed, followed by right trisectionectomy. Histopathological and immunohistochemical examinations of the lesion revealed UESL. Two months after the surgery, we initiated sarcoma-directed chemotherapy with doxorubicin because of multiple metastases to the liver. After initiating the chemotherapy, she received another regimen using gemcitabine/docetaxel, eribulin, trabectedin, ifosfamide/mesna, pazopanib, and cisplatin. During the chemotherapy, she underwent palliative surgery twice due to the progressive disease. She lived for 49 months after the initial operation. CONCLUSIONS: Improved long-term survival was achieved in an adult patient with UESL after multidisciplinary therapy, involving a combination of three surgical procedures and several chemotherapies.

  13. Adult Living Donor Liver Transplantation for the Carryover Patients After Kasai Operation Who Have a History of Multiple Laparotomies. 国際誌

    Shigehito Miyagi, Kengo Sasaki, Kazuaki Tokodai, Atsushi Fujio, Toshiaki Kashiwadate, Koji Miyazawa, Muneyuki Matsumura, Takashi Kamei, Michiaki Unno

    Transplantation proceedings　54　(2)　430-434　2022年3月

    DOI： 10.1016/j.transproceed.2021.09.073 　

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    OBJECTIVE: Approximately 50 years have passed since the Kasai operation announcement for biliary atresia. In adult liver failure cases, the so-called "the carryover cases after Kasai operation" have increased. These patients often underwent polysurgery. In such cases, adult living-donor liver transplantation (LDLT) is occasionally difficult. Many complications have been reported to be caused by severe cholangitis, hepatic portal regional inflammation, and adhesion. We investigated the complications of adult LDLT in post-Kasai biliary atresia cases with polysurgery. METHODS: Between 1991 and 2021, we performed 205 LDLT cases. We investigated the outcome of adult LDLT for post-Kasai biliary atresia cases (transplanted over 16 years old) (n = 20) and the risk factors for complications after LDLT. RESULTS: On 5 years overall survival, there were no significant differences between "adult LDLT for post-Kasai" group and the others (81.8% vs 81.2%). Adult LDLT for post-Kasai was not found to be a risk factor for complications. However, polysurgery before LDLT was an independent risk factor for biliary stenosis and portal stenosis, as identified in our univariate and multivariate analysis. We analyzed the relationship between biliary stenosis and the frequency of laparotomies using a receiver operating characteristic curve. The analysis showed that the cutoff point (maximum point of sensitivity plus specificity) was more than 3 times that of laparotomies before LDLT. CONCLUSIONS: In our study, adult LDLT for post-Kasai cases was not a risk factor for any complications. However, polysurgery before LDLT has been identified as a risk factor for biliary stenosis and portal vein stenosis.

  14. Optimal Conditions for Oxygenated Subnormothermic Machine Perfusion for Liver Grafts Using a Novel Perfusion Device. 国際誌

    Hiroyasu Nishimaki, Shigehito Miyagi, Toshiaki Kashiwadate, Kazuaki Tokodai, Atsushi Fujio, Koji Miyazawa, Kengo Sasaki, Takashi Kamei, Michiaki Unno

    Transplantation proceedings　54　(2)　217-224　2022年3月

    DOI： 10.1016/j.transproceed.2021.12.025 　

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    BACKGROUND: Liver transplantation from donors after cardiac death (DCD) resolves donor shortages. PURPOSE: We investigated the optimal time for subnormothermic oxygenated perfusion in DCD liver transplantation. METHODS: Ten F1 pigs (body weight: 27-32 kg) were allocated to 2 groups: the heart beating group (n = 6), from which livers were retrieved while the heart was beating, and the donation after cardiac death (DCD) group (n = 4), in which liver retrieval was performed on pigs under apnea-induced cardiac arrest for 20 minutes. In both groups, the livers were kept in cold storage for 2 hours after retrieval and perfused with a subnormothermic oxygenated Krebs-Henseleit buffer for 120 minutes. We used a novel perfusion device, which can set maximum perfusion pressures of arteries and portal vein, developed by Asahikawa Medical University and Chuo Seiko Co. Bile production, liver enzymes, and inflammatory cytokines were measured and the sinusoidal space, using tissue specimens taken from liver grafts, was measured at 30, 60, 90, and 120 minutes after the start of perfusion. RESULTS: Bile production peaked at 90 minutes. Significantly higher levels of liver enzymes and inflammatory cytokines were found in the DCD group (P < .05). The release of liver enzymes peaked at 60 minutes and that of inflammatory cytokines peaked at 90 minutes. The hepatic sinusoidal space was wide at 90 minutes and narrowed after 120 minutes. CONCLUSIONS: The results suggest that subnormothermic oxygenation perfusion may maintain optimal graft condition until around 90 minutes and perfusion for more than 120 minutes may be counterproductive.

  15. Cholesterol Granuloma of the Liver Mimicking Malignant Tumor: A Case Report.

    Yuki Ishikawa, Atsushi Fujio, Kazuaki Tokodai, Toshiaki Kashiwadate, Koji Miyazawa, Kengo Sasaki, Muneyuki Matsumura, Yoshikatsu Saitoh, Mio Tsuruoka, Jun Inoue, Shigehito Miyagi, Fumiyoshi Fujishima, Michiaki Unno, Takashi Kamei

    The Tohoku journal of experimental medicine　256　(3)　235-240　2022年3月

    DOI： 10.1620/tjem.256.235 　

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    Cholesterol granuloma is a benign, tumor-like lesion with an accumulation of cholesterol crystals in the tissue and is a consequence of a chronic inflammatory reaction. It commonly occurs in the middle ear but rarely in the liver. There is only one previous case report of cholesterol granuloma of the liver, which was caused by cholesterol hepatolithiasis. We report a case of cholesterol granuloma of the liver in a patient with no intrahepatic cholesterol stones; it was difficult to rule out malignant liver tumor preoperatively. The patient was a 79-year-old woman in whom a lesion in the liver was detected on abdominal ultrasonography. She was referred to our hospital for detailed examination and treatment. Abdominal contrast-enhanced computed tomography showed a 20 mm lesion with ring enhancement in the lateral segment of the liver during the arterial and delayed phases. Since a malignant tumor could not be ruled out radiologically, laparoscopic lateral segment hepatectomy was performed for definitive diagnosis and treatment. The resection specimen showed a yellowish-white lesion measuring 15 mm in diameter. Pathological examination showed a granulomatous lesion with cholesterol crystals surrounded by foreign body giant cells. The lesion was diagnosed as cholesterol granuloma of the liver. The postoperative course was good, and the patient was discharged on postoperative day 5. She was healthy, and no recurrence of the cholesterol granuloma was detected at the 5-month follow-up. This is the first case report of cholesterol granuloma of the liver mimicking a malignant liver tumor in a patient with no intrahepatic cholesterol stones.

  16. (Cast2021) Oxygenated Hypothermic Machine Perfusion of Kidney Transplantation from Donors After Cardiac Death Due to Long-Term Low Blood Pressure and Hypoxia: The First Case Report of a Clinical Trial Using a New Japanese Perfusion System. 国際誌

    Shigehito Miyagi, Toshiaki Kashiwadate, Hiroyasu Nishimaki, Kazuaki Tokodai, Atsushi Fujio, Koji Miyazawa, Kengo Sasaki, Muneyuku Matsumura, Michiaki Unno, Takashi Kamei, Naoto Matsuno

    Transplantation proceedings　2022年1月11日

    DOI： 10.1016/j.transproceed.2021.09.075 　

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    BACKGROUND: Machine perfusion of marginal kidney grafts obtained from donors after cardiac death (DCD) has become a standard therapy worldwide. However, the use of grafts from DCD due to long-term low blood pressure is associated with a high incidence of primary graft nonfunction. Furthermore, the importance of oxygenation in machine perfusion remains unclear. We report the first case of a clinical trial of a kidney transplant obtained from a DCD using a Japanese oxygenated hypothermic perfusion system (CMX-08W, Chuo Seiko Co Ltd, Asahikawa, Japan). PATIENTS AND METHODS: The donor was a 61-year-old man with amyotrophic lateral sclerosis. His SpO2 decreased to 80% to 90%, his blood pressure remained consistently low for 4 hours and 30 minutes, and he suffered a cardiac arrest. Subsequently, we carried him to the operating room. The warm ischemic time was 12 minutes, and the cold ischemic time was 418 minutes. The recipient was a 58-year-old man who had been undergoing hemodialysis for 26 years. He was diagnosed with nephrosclerosis and multiple renal cysts. Oxygenated hypothermic machine perfusion was used on the kidney transplant obtained from the DCD. RESULTS: The recipient gradually recovered and was withdrawn from hemodialysis therapy 14 days post transplantation. His renal function improved, and he was discharged on postoperative day 36. Currently, his renal function remains good (phosphocreatine, 1.7). CONCLUSIONS: Oxygenated machine perfusion is used to preserve organs and determine if an organ is suitable for transplantation. This may provide the possibility of perfusion preservation and expand the criteria for cardiac arrest-associated renal transplantation.

  17. Usefulness of Thiel-Embalmed Cadavers for Training in Organ Procurement. 国際誌

    Hiroaki Mitsugashira, Kazuaki Tokodai, Wataru Nakanishi, Atsushi Fujio, Toshiaki Kashiwadate, Koji Miyazawa, Kengo Sasaki, Shigehito Miyagi, Yuji Owada, Michiaki Unno, Takashi Kamei

    Transplantation proceedings　54　(2)　230-232　2022年1月11日

    DOI： 10.1016/j.transproceed.2021.10.026 　

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    BACKGROUND: The number of brain-dead donors has been increasing; however, the opportunity for young surgeons to experience deceased donor surgeries is extremely limited, especially in many Asian countries including Japan. Deceased donor surgeries require unique surgical skills and knowledge; however, it is difficult to provide on-the-job guidance and education. Therefore, cadaver training is meaningful and suitable for the training of deceased donor surgeries. Thiel's embalming method (TEM) provides natural coloration, flexibility, and tissue plasticity, and is widely used for cadaver surgical training. In this study, we evaluated the usefulness of Thiel's embalmed cadaver training for organ procurement surgery. MATERIAL AND METHODS: Each trainee performed hepatectomy, pancreatectomy, and nephrectomy using conventional open techniques. Faculty experts of transplantation surgery and organ procurement took attendees through surgical steps. After the procedure, all participants were asked to complete a voluntary, anonymous survey, consisting of a 10-point satisfaction scale, to evaluate their perceptions of the training. RESULTS: A total of 33 gastrointestinal surgeons participated in the training program for procuring the liver, pancreas, and kidneys. In the questionnaire administered to the participants, the evaluation was generally satisfactory, with an average of 9.1 points on the 10-point scales. Some participants expressed that Thiel-embalmed cadavers are more suitable for training on organ procurement compared with animals used in wet-lab training. CONCLUSION: We conclude that organ procurement training in human cadavers preserved by TEM is useful and suitable for practicing deceased donor organ procurement, especially in countries where deceased donors are not common, as in Japan.

  18. Doppler ultrasonography is a useful tool for the diagnosis of hemodynamics in congestive graft injury due to heart failure after liver transplantation: A case report 国際誌

    Kengo Sasaki, Kazuaki Tokodai, Atsushi Fujio, Shigehito Miyagi, Michiaki Unno, Takashi Kamei

    International Journal of Surgery Case Reports　88　106569-106569　2021年11月

    出版者・発行元： Elsevier BV

    DOI： 10.1016/j.ijscr.2021.106569 　

    ISSN：2210-2612

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    INTRODUCTION: Patients with end-stage liver disease often have cardiac dysfunction, which can be worsened by hemodynamic instability in liver transplantation, causing congestive graft injury. PRESENTATION OF CASE: A 28-year-old male with Wilson's disease underwent liver transplantation. The patient's history included cirrhotic cardiomyopathy and a preoperative ejection fraction of 37% on echocardiography. After liver transplantation, massive transfusion and acute renal failure led to increased central venous pressure. Doppler ultrasonography (US) showed an increase in positive components of the hepatic vein triphasic wave, followed by pulsatile changes in the portal vein waveforms and an eventual to-and-fro pattern. Laboratory data showed severe elevations of hepatocellular transaminase levels. Based on Doppler US findings, we determined liver damage was due to passive congestion caused by heart failure. Immediate initiation of continuous hemodiafiltration (CHDF) and intra-aortic balloon pumping (IABP) led to the patient's recovery from severe heart failure and graft injury. DISCUSSION: In our case, changes in the hepatic and portal vein waveforms and marked elevation of hepatocellular transaminases implied exacerbation of heart failure caused by hepatic congestion and injury. Worsening heart failure, in turn, led to progressive liver damage as the result of hepatic passive congestion. The patient's condition was successfully managed with early initiation of CHDF and IABP. CONCLUSION: Doppler US can help diagnose congestive graft injury due to heart failure in liver transplant patients and should be performed during post-transplant management of patients with cardiac dysfunction.

  19. Novel technique for recanalization of severe hepaticojejunal obstruction using a transseptal needle in a pediatric liver transplant recipient. 国際誌

    Kengo Sasaki, Hideki Ota, Shigehito Miyagi, Kazuaki Tokodai, Atsushi Fujio, Toshiaki Kashiwadate, Koji Miyazawa, Muneyuki Matsumura, Yoshikatsu Saitoh, Norifumi Kanai, Hiroyasu Nishimaki, Kei Takase, Michiaki Unno, Takashi Kamei

    Pediatric transplantation　26　(2)　e14160　2021年10月11日

    DOI： 10.1111/petr.14160 　

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    BACKGROUND: Endoscopic and PTB interventions are common nonsurgical interventions for biliary anastomotic strictures that occur after liver transplantation. When these nonsurgical interventions fail, surgical re-anastomosis is considered; however, this is quite invasive and can cause additional injury that may lead to graft loss. We report a case in which conventional nonsurgical interventions failed, but a new method that involve the use of a transseptal needle-a device to create a transseptal left-heart access during cardiac catheter interventions-was successfully used in recanalization of the hepaticojejunal anastomotic obstruction. CASE: A 21-year-old man, who had received living-donor liver transplantation for biliary atresia at the age of 23 months presented with recurrent cholangitis and liver dysfunction due to a biliary anastomotic stricture of the hepaticojejunostomy. Therapeutic interventions for biliary stricture, including the PTB approach, double-balloon enteroscopic approach, and rendezvous approach failed. We then performed needle puncture of the anastomotic obstruction using a transseptal needle and succeeded in recanalizing the complete anastomotic obstruction. To perform the procedures safely, we evaluated the organ and needle positions using biplane fluoroscopy and placed a balloon in the afferent jejunal limb as a target for puncture. The 12 Fr catheter via the biliary route was removed 7 months after the procedure, without using a catheter, there was no recurrent stricture or cholangitis for 26 months. CONCLUSION: Using a transseptal needle to manage hepaticojejunal anastomotic obstruction can reduce the number of patients who need surgical re-anastomosis.

  20. Living donor liver transplantation for Budd‒Chiari syndrome with right posterior segment graft and patch plasty using the superficial femoral vein: a case report. 国際誌

    Norikazu Une, Kazuaki Tokodai, Norifumi Kanai, Yoshikatsu Saitoh, Mineto Ohta, Kengo Sasaki, Koji Miyazawa, Toshiaki Kashiwadate, Atsushi Fujio, Wataru Nakanishi, Shigehito Miyagi, Michiaki Unno, Takashi Kamei

    Surgical case reports　7　(1)　136-136　2021年6月4日

    DOI： 10.1186/s40792-021-01224-5 　

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    BACKGROUND: In living donor liver transplantation (LDLT) for patients with Budd‒Chiari syndrome (BCS), there are several concerns about reconstruction of the inferior vena cava (IVC) and hepatic veins. Herein, we report the case of a patient with BCS who underwent LDLT with right posterior segment graft (RPSG) and patch plasty for reconstruction of the hepatic venous outflow, using the patient's own superficial femoral vein (SFV). CASE PRESENTATION: A 19-year-old man, who was diagnosed with primary BCS, underwent LDLT. His main hepatic veins were totally obstructed, and membranous stenosis was seen in the IVC. The LDLT donor was his mother; however, liver volumetric analysis showed that only her RPSG was appropriate. In the recipient surgery, 16 cm of the left SFV was harvested and was cut longitudinally and opened. The right hepatic vein (RHV) of the RPSG was anastomosed to the sidewall of the SFV graft. After explantation of native diseased liver was completed, the stenotic and thickened wall of the IVC was widely resected, and a large anastomotic orifice was created. Patch cavoplasty was performed with the RHV‒SFV graft patch. After portal reperfusion started, hepatic venous outflow was satisfactory, and there was no venous graft congestion. Both his postoperative course and his long-term course after discharge were uneventful. CONCLUSIONS: In LDLT for BCS patients, ingenuity is required for the reconstruction of venous outflow. The SFV patch can be safely harvested from liver transplant recipients and is suitable for venous reconstruction. In addition, RPSG is an alternative type of liver graft for LDLT if a conventional right- or left-lobe graft cannot be used.

  21. Laparoscopic liver cyst fenestration with real-time indocyanine green fluorescence-guided surgery: a case report. 国際誌

    Norikazu Une, Atsushi Fujio, Hiroaki Mitsugashira, Norifumi Kanai, Yoshikatsu Saitoh, Mineto Ohta, Kengo Sasaki, Koji Miyazawa, Toshiaki Kashiwadate, Wataru Nakanishi, Kazuaki Tokodai, Shigehito Miyagi, Michiaki Unno, Takashi Kamei

    Journal of surgical case reports　2021　(5)　rjab196　2021年5月

    DOI： 10.1093/jscr/rjab196 　

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    Laparoscopic fenestration (LF) has recently been considered a standard procedure for nonparasitic symptomatic liver cysts. Here, we report a case of LF that was safely performed using real-time indocyanine green (ICG) fluorescence-guided surgery. A 74-year-old woman presented with right upper abdominal pain and poor dietary intake. The patient was diagnosed with symptomatic liver cysts and underwent LF. One hour before surgery, ICG (2.5 mg) was intravenously administered to the patient. ICG fluorescence imaging clearly showed the biliary ducts and distinguished the cysts from the liver parenchyma. We could resect only the cyst walls as wide as possible under the guidance of both white light and fluorescence imaging. There were no signs of postoperative symptom recurrence. Detection of ICG fluorescence in the liver parenchyma is as important as ICG cholangiography for fenestration. Laparoscopic liver cyst fenestration with real-time ICG fluorescence-guided surgery is safe and can be used as a standard procedure.

  22. Bleeding from jejunal varices formed at the Roux-en-Y jejunum site caused by the compression of the left renal vein after living donor liver transplantation with renoportal anastomosis. 国際誌

    Wataru Nakanishi, Shigehito Miyagi, Kazuaki Tokodai, Atsushi Fujio, Toshiaki Kashiwadate, Kengo Sasaki, Yoshihiro Shono, Mineto Ohta, Yoshikatsu Saitoh, Michiaki Unno, Takashi Kamei

    Surgical case reports　7　(1)　43-43　2021年2月6日

    DOI： 10.1186/s40792-021-01129-3 　

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    BACKGROUND: Renoportal anastomosis is an option for the portal vein reconstruction of a liver transplantation with grade 4 portal vein thrombosis and a splenorenal shunt. Here, we report the case of gastrointestinal bleeding who underwent living donor liver transplantation (LDLT) with renoportal anastomosis. CASE PRESENTATION: Six-year-old female patient who underwent LDLT with renoportal anastomosis at 1 year of age had severe anemia with normal liver function during the follow-up period. The varices at the Roux-en-Y jejunum were considered the source of bleeding, and the compression of the left renal vein, which is known as a cause of Nutcracker syndrome, seemed to induce venous hypertension through the splenorenal shunt, which might induce the formation of the varices. She underwent percutaneous transhepatic sclerotherapy of the varices, and the anemia improved at her last follow-up, 6 months after sclerotherapy. This is the first reported case of Roux-en-Y jejunal varices bleeding related to the compression of the left renal vein after LDLT was performed with renoportal anastomosis. CONCLUSIONS: Although renoportal anastomosis should be cautiously performed when there are no options for severe portal vein thrombosis, the status of the left renal vein and new collateral formation should be observed carefully during the follow-up period in pediatric cases of renoportal anastomosis.

  23. Human Pluripotent Stem Cell-Derived Organoids as a Model of Intestinal Xenobiotic Metabolism

    Kengo Sasaki, Makoto Inoue, Masakazu Machida, Tomoyuki Kawasaki, Satoru Tsuruta, Hajime Uchida, Seisuke Sakamoto, Mureo Kasahara, Akihiro Umezawa, Hidenori Akutsu

    StemJournal　3　(1)　1-10　2021年1月18日

    出版者・発行元： IOS Press

    DOI： 10.3233/stj-200001 　

    ISSN：2468-8290

    eISSN：2468-8304

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    Background: The human intestine is the site of absorption and first-pass metabolism for oral intake. Assessment of absorption, distribution, metabolism, excretion, and toxicity (ADMET) of xenobiotics has transformed the understanding of in vivo pharmacology. However, these processes are difficult torecapitulate in vitro. Objective: We have developed a simple protocol for the generation of mature functional intestinal organoids from human pluripotent stem cells (hPSCs)under xenogeneic-free conditions. We sought to characterize transcription level in drug transporters and metabolism and evaluate CYP3A4 catalytic function of the organoids. Methods: Human pluripotent stem cell-derived intestinal organoids were generated and evaluated the expression of drug transporters and metabolizing enzymes. We examined the induction of CYP3A4 and ABCB1 gene expression in the organoids. Furthermore, we analyzed the CYP3A4 enzyme activity of the organoids by the p450-Glo CYP3A4 assay kit with luciferin isopropyl acetal. Results: Stem cell-derived intestinal organoids had an outward polarized intestinal epithelial layer and showed similar expression levels of drug transporters and metabolism genes as the adult healthy intestine. They also exhibited CYP3A4 enzymatic function in vitro. Conclusion: This model provides a novel platform for pharmacological testing and can enhance human ADMET studies in drug development.

  24. Effect of enhanced recovery after surgery protocol on recovery after open hepatectomy: a randomized clinical trial. 国際誌

    Wataru Nakanishi, Shigehito Miyagi, Kazuaki Tokodai, Atsushi Fujio, Kengo Sasaki, Yoshihiro Shono, Michiaki Unno, Takashi Kamei

    Annals of surgical treatment and research　99　(6)　320-328　2020年12月

    DOI： 10.4174/astr.2020.99.6.320 　

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    Purpose: Enhanced recovery after surgery (ERAS) is beneficial to patients undergoing digestive surgery. However, its efficacy in patients undergoing open hepatectomy remains unclear. Methods: Consecutive patients scheduled for open hepatectomy were randomly assigned to undergo either ERAS or conventional postoperative management. The primary endpoint was the amount of time that elapsed before patients were considered medically fit for discharge (MFD) and length of hospital stay (LOHS). Secondary endpoints included morbidity, mortality, the time to first flatus, defecation, first walk, and freedom from infusion. Perioperative serum nutritional markers, insulin resistance, respiratory quotient (RQ), and resting energy expenditure (REE) were also assessed. Results: Between August 2014 and March 2017, 57 patients were randomized into 2 groups; ERAS group (n = 29) and conventional management (n = 28). The median MFD was not significantly different between the ERAS and conventional management groups (6.5 vs. 7 days; P = 0.381). Recovery from gastrointestinal paresis was significantly quicker in the ERAS group (1.8 vs. 2.4 days; P = 0.004). There were no significant differences in serum markers, insulin resistance, RQ, and REE. Conclusion: This trial did not demonstrate greater efficacy of the ERAS protocol following open hepatectomy in terms of the MFD and LOHS. However, the ERAS protocol was associated with better recovery from postoperative gastrointestinal paresis, suggesting that it is useful for patients undergoing open hepatectomy.

  25. Risks of Living Donor Liver Transplantation Using Small-For-Size Grafts

    Shigehito Miyagi, Yoshihiro Shono, Kazuaki Tokodai, Wataru Nakanishi, Ryuichi Nishimura, Atsushi Fujio, Kengo Sasaki, Yuki Miyazaki, Yuta Kakizaki, Hideaki Sasajima, Takashi Kamei, Michiaki Unno

    Transplantation Proceedings　52　(6)　1825-1828　2020年7月

    出版者・発行元： Elsevier BV

    DOI： 10.1016/j.transproceed.2020.01.136 　

    ISSN：0041-1345

  26. ABO-incompatible liver transplantation for children under 2 years of age: A case report and a single-center review. 国際誌 査読有り

    Soichi Narumoto, Seisuke Sakamoto, Kengo Sasaki, Yoshihiro Hirata, Akinari Fukuda, Toru Uchiyama, Rie Irie, Takako Yoshioka, Mureo Kasahara

    Pediatric transplantation　23　(1)　e13308　2019年2月

    DOI： 10.1111/petr.13308 　

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    Desensitization with RTX has been broadly introduced in adult LT across the ABO blood type barrier. For pediatric LT, the prophylactic use of RTX has not been standardized, especially for children under 2 years of age. A 20-month-old girl with BA underwent living donor LT from her ABO-I mother. On POD 6, she developed combined T cell-mediated and AMRs. Steroid bolus injection was immediately introduced, followed by antibody-depleting therapy with PE and IVIG. Based on a peripheral blood lymphocyte analysis by fluorescence-activated cell sorting, ATG and RTX were introduced for refractory rejection. Although she recovered from the combined rejections, IHBCs were inevitable as a consequence. We recommend extending the desensitization protocol to cover children under 2 years of age in order to prevent life-threatening complications.

  27. Mild to Moderate Intrapulmonary Shunting in Pediatric Liver Transplantation: Is Screening Necessary? 国際誌

    V P Mali, A Fukuda, T Shigeta, H Uchida, H Kanazawa, Y Hirata, T Rahayatri, B Chiaki, K Sasaki, M Kitamura, S Sakamoto, M Kasahara

    Transplantation proceedings　50　(10)　3496-3500　2018年12月

    DOI： 10.1016/j.transproceed.2018.05.025 　

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    BACKGROUND: Despite reported associations between intrapulmonary vascular shunting (IPVS) and morbidity and mortality in pediatric liver transplantation (LT), there are no guidelines for screening. OBJECTIVE: To investigate IPVS before and after pediatric LT. METHODS: Retrospective records review of all pediatric LT (n = 370) from 2005 to 2015 at a single institute in Japan. All children with cirrhosis and clinical suspicion of IPVS without cardiac or pulmonary conditions were included. 99mTechnetium labelled macroaggregated albumin (99mTcMAA) scans were performed before and after LT. The severity of IPVS was graded using shunt ratios. RESULTS: Twenty-four children fulfilled inclusion criteria and underwent Tc99MAA scans. All revealed mild (<20%) to moderate (20%-40%) grades of IPVS. Following LT, the mean shunt ratio regressed from 20.69 ± 6.26% to 15.1 ± 3.4% (P = .06). The median (range) follow-up was 17 (4-85) months. Mortality was zero. The incidence of portal vein thrombosis (4.2%) biliary strictures (12.5%) and graft loss (4.1%) in the study group was not statistically significant compared to the remainder of the 370 transplants (3.2%, 9.4% and 3%, respectively). Sub-group analysis revealed hepatopulmonary syndrome (HPS) in 2 out of 24 children. The mean shunt ratios before and after LT were 39.2 ± 0.77% and 16.2 ± 8.5%, respectively (P = .08). There was 1 complication (intra-abdominal abscess). CONCLUSIONS: HPS is less likely in mild to moderate IPVS. LT may achieve comparable results when performed in the presence of mild to moderate IPVS.

  28. 【小児の機能性消化管疾患-機能性の嘔吐・腹痛・下痢・便秘】慢性特発性偽性腸閉塞(CIIP)に対する小腸移植の現状

    武田 昌寛, 阪本 靖介, 福田 晃也, 佐々木 健吾, 内田 孟, 平田 義弘, 笠原 群生

    小児内科　50　(12)　2032-2034　2018年12月

    出版者・発行元： (株)東京医学社

    ISSN：0385-6305

  29. Surgical treatment strategy for advanced hepatoblastoma: Resection versus transplantation. 国際誌 査読有り

    Hajime Uchida, Seisuke Sakamoto, Kengo Sasaki, Masahiro Takeda, Yoshihiro Hirata, Akinari Fukuda, Tomoro Hishiki, Rie Irie, Atsuko Nakazawa, Osamu Miyazaki, Shunsuke Nosaka, Mureo Kasahara

    Pediatric blood & cancer　65　(12)　e27383　2018年12月

    DOI： 10.1002/pbc.27383 　

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    BACKGROUND: Excellent outcomes of the extreme procedure of liver resection (LR) for advanced hepatoblastoma (HB) have been achieved in recent reports. However, liver transplantation (LT) remains the only surgical treatment for patients with unresectable HB. The aim of this study was to evaluate our retrospective data for cases of advanced HB necessitating surgical intervention and analyze the prognostic factors of recurrence by comparing patients with tumors resected by LR and LT. PATIENTS AND METHODS: We retrospectively reviewed 24 children with PRETEXT II/III/IV tumors that required consideration for LT between August 2011 and September 2016. RESULT: The staging at the time of the diagnosis was PRETEXT II/III/IV in 1/13/10 patients, respectively, while the preoperative staging after neoadjuvant chemotherapy was POSTTEXT II/III/IV in 5/17/2 patients. Among those 24 patients, complete resection of the primary tumor was achieved with LT in 12 patients and LR in 12 patients. A high serum level of alpha-fetoprotein (AFP) at the time of surgery, no significant decrease in the rate of change of AFP, and low tumor shrinkage rate were related to the risk of tumor recurrence, and patients with tumors resected by LR with those risks had a higher recurrence rate than those without them. The overall survival was higher in patients with tumors resected by LT (100%) than in patients with tumors resected by LR. CONCLUSION: Patients with advanced HB with a poor response to chemotherapy should definitively be prioritized for primary LT, given the possibility of vascular invasion and microscopic residual tumor.

  30. Novel technique for pediatric living donor liver transplantation in patients with portal vein obstruction: The "pullout technique". 国際誌 査読有り

    Mureo Kasahara, Kengo Sasaki, Hajime Uchida, Yoshihiro Hirata, Masahiro Takeda, Akinari Fukuda, Seisuke Sakamoto

    Pediatric transplantation　22　(8)　e13297　2018年12月

    DOI： 10.1111/petr.13297 　

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    PV hypoplasia may increase the risk of posttransplant complications, especially when it extends to near the SMV and SpV junction. We described our experience of 10 pediatric cases of PV hypoplasia/thrombus in which the pullout technique was required for PV reconstruction. There were five male and five female patients. The median age was 9 months, and the median weight was 8.1 kg. The indications for the pullout technique were PV hypoplasia in seven patients and PV thrombus in 3. The inflow sites of the enlarged LGV were as follows: the main PV trunk (n = 2), the SMV and SpV junction (n = 4), and the SpV (n = 4). The posterior face of the pancreas was tunneled along the PV, and the PV was returned to its original position with or without the use of an interposed vein graft. The pullout technique created a good operative field, which allowed for the complete removal of the hypoplastic PV or thrombectomy with the safe use of various interposed vein grafts.

  31. 【小児医療における診断・治療の進歩2018】治療技術 肝移植による代謝性疾患の治療

    佐々木 健吾, 阪本 靖介, 笠原 群生

    小児科　59　(12)　1801-1808　2018年11月

    出版者・発行元： 金原出版(株)

    ISSN：0037-4121

  32. 国立成育医療研究センターにおける肝移植500例の成績

    笠原 群生, 内田 孟, 佐々木 健吾, 平田 義弘, 武田 昌寛, 上遠野 雅美, 久保田 智美, 中里 弥生, 福田 晃也, 阪本 靖介

    移植　53　(2-3)　197-208　2018年11月

    出版者・発行元： (一社)日本移植学会

    ISSN：0578-7947

    eISSN：2188-0034

  33. Impact of graft thickness reduction of left lateral segment on outcomes following pediatric living donor liver transplantation. 国際誌 査読有り

    Toshihiro Kitajima, Seisuke Sakamoto, Kengo Sasaki, Soichi Narumoto, Kourosh Kazemi, Yoshihiro Hirata, Akinari Fukuda, Rumi Imai, Osamu Miyazaki, Rie Irie, Satoshi Teramukai, Shinji Uemoto, Mureo Kasahara

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons　18　(9)　2208-2219　2018年9月

    DOI： 10.1111/ajt.14875 　

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    Reducing graft thickness is essential to prevent large-for-size graft problems in pediatric living donor liver transplantation (LDLT). However, long-term outcomes of LDLT using reduced-thickness left lateral segment (LLS) grafts are unclear. In 89 patients who underwent LDLT using reduced LLS grafts between 2005 and 2017, short-term and long-term outcomes were compared between a nonanatomically reduced LLS (NAR-LLS) graft group and a reduced-thickness LLS graft group. Estimated blood loss was lower and abdominal skin closure was less needed in the recipient operation in the reduced-thickness LLS graft group. Postoperatively, portal vein (PV) flow was significantly decreased in the NAR-LLS graft group, and there was shorter intensive care unit (ICU) stay and fewer postoperative complications, especially bacteremia, in the reduced-thickness LLS graft group. Graft survival at 1 and 3 years after LDLT using reduced-thickness LLS grafts was 95.2% and 92.4%, respectively, which was significantly better than for NAR-LLS grafts. Multivariate analysis revealed that fulminant liver failure, hepatofugal PV flow before LDLT, and NAR-LLS graft were associated with poor graft survival. In conclusion, LDLT using reduced-thickness LLS grafts is a safe and feasible option with better short- and long-term outcomes in comparison with NAR-LLS grafts.

  34. Histological changes of the intestinal mucosa in complications following a living donor liver transplantation for progressive familial intrahepatic cholestasis type 1. 国際誌 査読有り

    Marini Stephanie, Rie Irie, Kengo Sasaki, Yoshihiro Hirata, Soichi Narumoto, Akinari Fukuda, Seisuke Sakamoto, Katsuhiro Arai, Takako Yoshioka, Mureo Kasahara

    Pathology international　68　(9)　536-537　2018年9月

    DOI： 10.1111/pin.12686 　

  35. A novel technique for collateral interruption to maximize portal venous flow in pediatric liver transplantation. 国際誌 査読有り

    Seisuke Sakamoto, Kengo Sasaki, Toshihiro Kitajima, Yoshihiro Hirata, Soichi Narumoto, Kourosh Kazemi, Akinari Fukuda, Osamu Miyazaki, Shunsuke Nosaka, Mureo Kasahara

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society　24　(7)　969-973　2018年7月

    DOI： 10.1002/lt.25016 　

  36. 【胆道・膵疾患術後の晩期障害】小児肝移植後の晩期門脈関連合併症に対する経皮的カテーテル治療について

    平田 義弘, 阪本 靖介, 佐々木 健吾, 福田 晃也, 宮嵜 治, 野坂 俊介, 笠原 群生

    胆と膵　39　(5)　427-434　2018年5月

    出版者・発行元： 医学図書出版(株)

    ISSN：0388-9408

  37. Modified triangular hepatic vein reconstruction for preventing hepatic venous outflow obstruction in pediatric living donor liver transplantation using left lateral segment grafts. 国際誌 査読有り

    Akinari Fukuda, Seisuke Sakamoto, Kengo Sasaki, Soichi Narumoto, Toshihiro Kitajima, Yoshihiro Hirata, Tomoro Hishiki, Mureo Kasahara

    Pediatric transplantation　22　(3)　e13167　2018年5月

    DOI： 10.1111/petr.13167 　

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    HVOO can be a critical complication in pediatric LDLT. The aim of this study was to evaluate a modified triangular technique of hepatic vein reconstruction for preventing HVOO in pediatric LDLT. A total of 298 pediatric LDLTs were performed using a left lateral segment graft by 2 methods for reconstruction of the hepatic vein. In 177 recipients, slit-shaped anastomosis was indicated with partial clamp of the IVC. A total of 121 recipients subjected to the modified triangular anastomosis with total clamp of the IVC. We compared the incidence of hepatic vein anastomotic complications between these 2 methods. Nine of the 177 cases (5.3%) treated with the conventional technique were diagnosed with outflow obstruction. All 9 cases underwent hepatic vein reconstruction with the slit-shaped hepatic vein anastomosis. In contrast, there were no cases of outflow obstruction in the 121 cases treated with the modified triangular anastomosis. The modified triangular technique of hepatic vein reconstruction with total clamping of the IVC was useful for preventing HVOO in pediatric LDLT.

  38. Ex vivo reduction of thickness in the left lateral section to tailor the graft size in infantile split deceased donor liver transplantation. 国際誌 査読有り

    Seisuke Sakamoto, Kengo Sasaki, Hajime Uchida, Toshihiro Kitajima, Soichi Narumoto, Yoshihiro Hirata, Tomoro Hishiki, Akinari Fukuda, Mureo Kasahara

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society　24　(3)　428-431　2018年3月

    DOI： 10.1002/lt.24976 　

  39. A severely cholestatic liver graft can be successfully used in deceased donor liver transplantation. 国際誌 査読有り

    Seisuke Sakamoto, Kengo Sasaki, Hajime Uchida, Soichi Narumoto, Toshihiro Kitajima, Rie Irie, Akinari Fukuda, Takako Yoshioka, Mureo Kasahara

    Hepatology research : the official journal of the Japan Society of Hepatology　48　(3)　E367-E371　2018年2月

    DOI： 10.1111/hepr.12968 　

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    The shortage of deceased organs is still a serious issue in Japan. A proactive approach to using liver grafts from extended criteria donors (ECDs) may be one way of expanding the donor pool; however, if it is recklessly attempted, a recipient receiving such a marginal graft can be at risk of mortality due to primary non-function or delayed graft function. We herein report the successful outcome of a recipient receiving a severely cholestatic graft that was considered transplantable because it lacked features characteristic of a long duration of "cholestasis" according to the precise interpretation of a donor biopsy. Plasma exchange was intentionally introduced to prevent toxic insult by hyperbilirubinemia immediately after transplant. Despite transient acute kidney injury immediately after transplant, the patient's renal impairment was well managed with a renal-sparing immunosuppressive regimen consisting of basiliximab and mycophenolate mofetil. Although the use of liver grafts from ECDs still needs to be discussed, especially regarding graft selection and allocation policies, efforts not to discard valuable grafts should be undertaken in our country.

  40. Necrotizing enterocolitis in the setting of milk allergy after pediatric living donor liver transplantation. 国際誌 査読有り

    Soichi Narumoto, Seisuke Sakamoto, Hajime Uchida, Kengo Sasaki, Takanobu Shigeta, Akinari Fukuda, Shunsuke Nosaka, Rie Irie, Takako Yoshioka, Mureo Kasahara

    Pediatric transplantation　22　(1)　2018年2月

    DOI： 10.1111/petr.13096 　

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    NEC is an idiopathic intestinal mucosal injury that may progress to transmural bowel necrosis without mesenteric ischemia. NEC usually affects 7- to 10-day-old neonates following enteral feeding. A 10-month-old girl with no history of laparotomy underwent LDLT for acute liver failure. After starting enteral feeding on postoperative day 5, she developed abdominal distention. Diffuse PVG and PI were detected by radiologic modalities. Exploratory laparotomy revealed patchy necrosis of the intestine without perforation. The microscopic findings of a resected specimen revealed transmural coagulative necrosis with multiple small thromboses compatible with neonatal NEC features, and eosinophil infiltration was also observed. Subsequently, after the resumption of enteral feeding with cow's milk, she developed severe diarrhea, the symptoms of which were eliminated after the administration of cow's milk was stopped. These clinical and pathological findings support the speculation that NEC might have been induced by a CMA. Food allergies, which can be induced by immunosuppressive agents, should be considered as a potential cause of NEC in the setting of pediatric liver transplantation.

  41. Organoids recapitulate organs? 国際誌 査読有り

    Tohru Sugawara, Kengo Sasaki, Hidenori Akutsu

    Stem cell investigation　5　3-3　2018年

    DOI： 10.21037/sci.2018.01.02 　

  42. Optimizing hepatic venous outflow reconstruction for hepatic vein stenosis with indwelling stent in living donor liver retransplantation. 国際誌 査読有り

    Takanobu Shigeta, Seisuke Sakamoto, Kengo Sasaki, Hajime Uchida, Soichi Narumoto, Akinari Fukuda, Mureo Kasahara

    Pediatric transplantation　21　(8)　2017年12月

    DOI： 10.1111/petr.13044 　

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    The patient was a boy of 7 years and 5 months of age, who underwent LDLT for acute liver failure at 10 months of age. HV stent placement was performed 8 months after LDLT because of intractable HV stenosis. At 7 years of age, his liver function deteriorated due to chronic rejection. The patient therefore underwent living donor liver retransplantation from his father. The HV was transected with the stent in situ. The IVC was resected due to stenosis. The pericardial cavity was opened and detached around the IVC to elongate the IVC. The divided ends of the IVC were joined by suturing to the posterior wall of the IVC. A new triangular orifice was made by adding an incision on the anterior wall of the IVC. The graft HV was then anastomosed to the new orifice with continuous sutures in the posterior wall and interrupted sutures in the anterior wall using 5-0 non-absorbable sutures. Doppler ultrasound showed a triphasic waveform. We successfully performed HV reconstruction without a vascular graft. This is a feasible procedure for overcoming HV stenosis in LDLT patients with an indwelling stent.

  43. Sequential analysis of variable markers for predicting outcomes in pediatric patients with acute liver failure. 国際誌 査読有り

    Hajime Uchida, Seisuke Sakamoto, Akinari Fukuda, Kengo Sasaki, Takanobu Shigeta, Shunsuke Nosaka, Masaya Kubota, Atsuko Nakazawa, Satoshi Nakagawa, Mureo Kasahara

    Hepatology research : the official journal of the Japan Society of Hepatology　47　(12)　1241-1251　2017年11月

    DOI： 10.1111/hepr.12859 　

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    AIM: Our aim was to analyze serial changes in the predictive variables and a scoring system retrospectively adapted to evaluate outcomes in pediatric patients with acute liver failure (ALF). METHODS: We retrospectively collected data on 65 patients with ALF. The 65 patients were divided into two groups according to the need for liver transplantation (LT) as follows: LT group (n = 54) and non-LT group (n = 11). The early determination scoring system of the indications for LT proposed by the Intractable Hepato-Biliary Diseases Study Group of Japan (JIHBDSG) was used in our study. The area under the receiver operating characteristic curve (AUROC) was calculated for the JIHBDSG score between the LT group and non-LT group at the time of diagnosis (day 0) and day 3, and day 5 after the diagnosis. RESULTS: A JIHBDSG score of >3 at day 5 was found to identify the patients requiring LT with 83.7% sensitivity, 81.8% specificity, and 83.3% diagnostic accuracy. Based on a comparison of AUROC values, the JIHBDSG score on day 5 (AUROC 0.91) was higher than that on day 0 (AUROC 0.75) and day 3 (AUROC 0.84). CONCLUSION: We showed that a serial analysis of the JIHBDSG score might be useful for predicting outcomes of ALF in pediatric patients who fulfilled the criteria of LT indication in our center. However, further studies are needed to validate our results.

  44. Living donor liver transplantation for post-Kasai biliary atresia: Analysis of pretransplant predictors of outcomes in infants. 国際誌 査読有り

    Toshihiro Kitajima, Seisuke Sakamoto, Kengo Sasaki, Hajime Uchida, Soichi Narumoto, Akinari Fukuda, Satoshi Teramukai, Shinji Uemoto, Mureo Kasahara

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society　23　(9)　1199-1209　2017年9月

    DOI： 10.1002/lt.24796 　

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    After decades of dramatic surgical innovations in pediatric living donor liver transplantation (LDLT), LDLT for biliary atresia (BA) still poses various challenges. This study reviewed our experience with LDLT for children with post-Kasai BA and evaluated outcomes and prognostic factors. From 2005 to 2016, 168 post-Kasai BA LDLT patients were enrolled and divided into 3 groups by age. Patient characteristics and perioperative data were compared. Predictors of morbidity and mortality following LDLT were analyzed in 93 infants. Outcome was relatively worse in infants than older children, with overall survival at 1 and 5 years of 94.5% and 93.2%, respectively, and graft survival at 1 and 5 years of 91.1% each. Incidence of vascular complications was not significantly higher in infants. High Pediatric End-Stage Liver Disease (PELD) score (odds ratio [OR], 3.72; 95% confidence interval [CI], 1.30-10.67; P = 0.02) and portal vein (PV) hypoplasia (OR, 3.23; 95% CI, 1.10-9.52; P = 0.03) were independent risk factors for morbidity. Low weight-for-age z score (hazard ratio, 5.76; 95% CI, 1.05-31.47; P = 0.03) was identified as a significant risk factor for mortality after LDLT, but not age or absolute body weight (BW). Infants with BW deficit had a significantly smaller PV diameter (P = 0.005), greater blood loss (P = 0.001), and higher incidence of postoperative bacteremia (P = 0.01). In conclusion, high PELD score and PV hypoplasia were independent risk factors for morbidity, and BW deficit was associated with poor survival in infants with post-Kasai BA after LDLT. However, LDLT in these infants at the earliest possible time after referral is a feasible option with excellent patient survival in an experienced center. Liver Transplantation 23 1199-1209 2017 AASLD.

  45. Living donor liver transplantation during the first 3 months of life. 国際誌 査読有り

    Mureo Kasahara, Seisuke Sakamoto, Kengo Sasaki, Hajime Uchida, Toshihiro Kitajima, Takanobu Shigeta, Soichi Narumoto, Yoshihiro Hirata, Akinari Fukuda

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society　23　(8)　1051-1057　2017年8月

    DOI： 10.1002/lt.24743 　

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    Living donor liver transplantation (LDLT) is now an established technique for treating children with end-stage liver disease. Few data exist about liver transplantation (LT) for exclusively young infants, especially infants of <3 months of age. We report our single-center experience with 12 patients in which LDLT was performed during the first 3 months of life and compare the results with those of older infants who underwent LT. All of the patients were treated at the National Center of Child Health and Development, Tokyo, Japan. Between November 2005 to November 2016, 436 children underwent LT. Twelve of these patients underwent LT in the first 3 months of life (median age, 41 days; median weight, 4.0 kg). The indications for transplantation were fulminant hepatic failure (n = 11) and metabolic liver disease (n = 1). All the patients received the left lateral segment (LLS) in situ to mitigate the problem of graft-to-recipient size discrepancy. A reduced LLS graft was used in 11 patients and a segment 2 monosegment graft was used in 1 patient. We compared the results with those of infants who were 4-6 months of age (n = 67) and 7-12 months of age (n = 110) who were treated in the same study period. There were significant differences in the Pediatric End-Stage Liver Disease score and the conversion rate of tacrolimus to cyclosporine in younger infants. Furthermore, the incidence of biliary complications, bloodstream infection, and cytomegalovirus infection tended to be higher, whereas the incidence of acute cellular rejection tended to be lower in younger infants. The overall cumulative 10-year patient and graft survival rates in recipients of <3 months of age were both 90.9%. LDLT during the first 3 months of life appears to be a feasible option with excellent patient and graft survival. Liver Transplantation 23 1051-1057 2017 AASLD.

  46. Liver Transplantation for Mitochondrial Respiratory Chain Disorder: A Single-Center Experience and Excellent Marker of Differential Diagnosis 査読有り

    K. Sasaki, S. Sakamoto, H. Uchida, S. Narumoto, T. Shigeta, A. Fukuda, R. Ito, R. Irie, T. Yoshioka, K. Murayama, M. Kasahara

    TRANSPLANTATION PROCEEDINGS　49　(5)　1097-1102　2017年6月

    DOI： 10.1016/j.transproceed.2017.03.065 　

    ISSN：0041-1345

    eISSN：1873-2623

  47. Successful resumption of peritoneal dialysis following living donor liver transplantation in children with end-stage renal disease. 国際誌 査読有り

    Hiroyuki Kanazawa, Akinari Fukuda, Mai Sato, Shingo Ishimori, Kengo Sasaki, Hajime Uchida, Takanobu Shigeta, Vidyadhar Padmakar Mali, Seisuke Sakamoto, Kenji Ishikura, Mureo Kasahara

    Pediatric transplantation　21　(3)　2017年5月

    DOI： 10.1111/petr.12897 　

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    Children with ESRD in need of RRT are commonly managed by PD due to difficulty with vascular access for HD and the relatively large extracorporeal blood volume required. Major abdominal surgery may result in injury to the peritoneum and consequent adhesion, thereby resulting in a reduction in the anatomical capacity and transport capability across the peritoneal membrane. Here, we report successful resumption of PD after LDLT in two pediatric patients. The causes of ESRD were PH1 and juvenile nephronophthisis, respectively. Both patients were managed by PD prior to LDLT. PD was converted to HD starting three days before LDLT and was continued postoperatively until resumption of PD on days 13 and 28, respectively. The PD weekly Kt/V urea was maintained before and after LDLT. The patients continued to do well on PD without complications. Meticulous intra-operative techniques during LDLT allow postoperative PD resumption by preservation of peritoneal integrity with effective transport capability and without added risk of peritonitis.

  48. Hyperammonemia in ornithine transcarbamylase-deficient recipients following living donor liver transplantation from heterozygous carrier donors. 国際誌 査読有り

    Tri Hening Rahayatri, Hajime Uchida, Kengo Sasaki, Takanobu Shigeta, Yoshihiro Hirata, Hiroyuki Kanazawa, Vidyadhar Mali, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara

    Pediatric transplantation　21　(1)　2017年2月

    DOI： 10.1111/petr.12848 　

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    Ornithine transcarbamylase deficiency (OTCD) is a urea cycle disorder of X-linked inheritance, affecting the detoxification of excess nitrogen and leading to hyperammonemia (hyper-NH3 ). Living donor liver transplantation (LDLT) has been applied for the treatment of OTCD. This case series retrospectively reviewed two OTCD patients who experienced hyper-NH3 following LDLT. The first case was a 5-year-old girl who had onset of OTCD at 2 years of age. Ornithine transcarbamylase (OTC) enzyme activity was 62% for the donor and 15% for the recipient. The patient suffered from recurrence of hyper-NH3 within 2 months following LDLT. The second case was a 5-year-old girl who had onset of OTCD at 3 years of age. OTC enzyme activity was 42.6% for the donor and 9.7% for the recipient. The patient suffered hyper-NH3 for 12 days starting on the date of surgery. Both of the patients transiently required continuous veno-venous hemodialysis; however, they are currently doing well without intensive medical treatment. The use of asymptomatic OTCD heterozygous donors in LDLT has been accepted with careful examination. However, an OTCD heterozygous carrier donor should be avoided if there is another donor candidate, due to the potentially fatal condition of hyper-NH3 following LDLT.

  49. A xenogeneic-free system generating functional human gut organoids from pluripotent stem cells. 国際誌 査読有り

    Hajime Uchida, Masakazu Machida, Takumi Miura, Tomoyuki Kawasaki, Takuya Okazaki, Kengo Sasaki, Seisuke Sakamoto, Noriaki Ohuchi, Mureo Kasahara, Akihiro Umezawa, Hidenori Akutsu

    JCI insight　2　(1)　e86492　2017年1月12日

    DOI： 10.1172/jci.insight.86492 　

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    Functional intestines are composed of cell types from all 3 primary germ layers and are generated through a highly orchestrated and serial developmental process. Directed differentiation of human pluripotent stem cells (hPSCs) has been shown to yield gut-specific cell types; however, these structures do not reproduce critical functional interactions between cell types of different germ layers. Here, we developed a simple protocol for the generation of mature functional intestinal organoids from hPSCs under xenogeneic-free conditions. The stem cell-derived gut organoids produced here were found to contain distinct types of intestinal cells, including enterocytes, goblet cells, Paneth cells, and enteroendocrine cells, that were derived from all 3 germ layers; moreover, they demonstrated intestinal functions, including peptide absorption, and showed innervated bowel movements in response to stimulation with histamine and anticholinergic drugs. Importantly, the gut organoids obtained using this xenogeneic-free system could be stably maintained in culture for prolonged periods and were successfully engrafted in vivo. Our xenogeneic-free approach for generating gut organoids from hPSCs provides a platform for studying human intestinal diseases and for pharmacological testing.

  50. Total internal biliary diversion during liver transplantation for type 1 progressive familial intrahepatic cholestasis: a novel approach 査読有り

    V. P. Mali, A. Fukuda, T. Shigeta, H. Uchida, Y. Hirata, T. H. Rahayatri, H. Kanazawa, K. Sasaki, J. de Ville de Goyet, M. Kasahara

    Pediatric Transplantation　20　(7)　981-986　2016年11月1日

    出版者・発行元： Blackwell Publishing Inc.

    DOI： 10.1111/petr.12782 　

    ISSN：1399-3046 1397-3142

  51. Benefit of early inflow exclusion during living donor liver transplantation for unresectable hepatoblastoma. 国際誌 査読有り

    Hajime Uchida, Akinari Fukuda, Kengo Sasaki, Yoshihiro Hirata, Takanobu Shigeta, Hiroyuki Kanazawa, Atsuko Nakazawa, Osamu Miyazaki, Shunsuke Nosaka, Vidyadhar Padmakar Mali, Seisuke Sakamoto, Mureo Kasahara

    Journal of pediatric surgery　51　(11)　1807-1811　2016年11月

    DOI： 10.1016/j.jpedsurg.2016.04.021 　

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    BACKGROUND: Hepatoblastoma (HB) is a highly malignant primary liver tumor in children. Although liver transplantation (LT) is an effective treatment for unresectable HB with good long-term outcomes, post-transplant survival is mainly affected by recurrence, despite adjuvant chemotherapy. Novel strategies are needed to improve the outcomes in patients undergoing LT for unresectable HB. PATIENTS AND METHODS: Twelve children received LT for unresectable HB. In 9 patients, we applied early exclusion of hepatic inflow (hepatic artery and portal vein) and creation of a temporary portocaval shunt during LT. RESULT: There were differences in the duration of and the blood loss during operation as compared with previously reports. The estimated glomerular filtration rate was well preserved at 3, 6, and 12months and the latest follow-up after LT, and the recurrence-free survival was 88.9%. CONCLUSION: Early inflow control during LT for unresectable HB may benefit recurrence-free survival by minimizing blood loss and tumor dissemination, preserving renal function and allowing early adjuvant chemotherapy.

  52. Living donor domino liver transplantation using a maple syrup urine disease donor: A case series of three children - The first report from Japan. 国際誌 査読有り

    Masatoshi Matsunami, Akinari Fukuda, Kengo Sasaki, Hajime Uchida, Takanobu Shigeta, Yoshihiro Hirata, Hiroyuki Kanazawa, Reiko Horikawa, Atsuko Nakazawa, Tatsuya Suzuki, Koichi Mizuta, Mureo Kasahara

    Pediatric transplantation　20　(5)　633-9　2016年8月

    DOI： 10.1111/petr.12681 　

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    As the priority of LD-Domino LT is the safety of the first recipient, limitations and technical difficulties in the second recipient often occur. The most technically challenging part of LD-Domino LT is the reconstruction of the vessels. For the reconstruction of HVs, the native HVs were exteriorized as far as possible using a CUSA because longer extensive HVs are essential for facilitating the reconstruction. At the back table, the HVs of the domino graft were sutured together, and the single cuff of the HVs was anastomosed to the IVC by joining the orifices. The HAs, the presence of insufficient length, and multiple vessels in the whole liver rendered the reconstruction more difficult. We determined the dividing sites of the vessels according to the preoperative 3D-CT findings obtained in two institutions. This is the first case series using grafts in DLT obtained from LDLT for patients with MSUD between two institutions. In conclusion, LD-Domino LT is a safe and feasible therapeutic option to expand the donor pool by technical refinement in the reconstruction of the second recipient. Further studies with a greater accumulation of patients and a longer follow-up will be necessary to establish LD-Domino LT using an MSUD donor.

  53. Reno- and splenoportal anastomosis for a retransplant patient with situs inversus 査読有り

    Hajime Uchida, Akinari Fukuda, Kengo Sasaki, Takanobu Shigeta, Yoshihiro Hirata, Hiroyuki Kanazawa, Vidyadhar Padmakar Mali, Osamu Miyazaki, Shunsuke Nosaka, Seisuke Sakamoto, Kasahara Mureo

    PEDIATRIC TRANSPLANTATION　20　(4)　594-596　2016年6月

    DOI： 10.1111/petr.12703 　

    ISSN：1397-3142

    eISSN：1399-3046

  54. Chemotherapy-induced B-cell depletion in hepatoblastoma patients undergoing ABO-incompatible living donor liver transplantation. 国際誌 査読有り

    Hiroyuki Kanazawa, Akinari Fukuda, Vidyadhar Padmakar Mali, Tri Hening Rahayatri, Yoshihiro Hirata, Kengo Sasaki, Hajime Uchida, Takanobu Shigeta, Seisuke Sakamoto, Kimikazu Matsumoto, Mureo Kasahara

    Pediatric transplantation　20　(3)　401-7　2016年5月

    DOI： 10.1111/petr.12675 　

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    LT from ABO-I donors requires preconditioning regimens to prevent postoperative catastrophic AMR. NAC for HBL is known to cause myelosuppression leading to a reduction in the number and function of lymphocytes. We investigated this chemotherapy-induced myelosuppression in HBL patients listed for LT from ABO-I donors with reference to the kinetics of B, T cells, and anti-ABO blood type isoagglutinin titers. Between 2005 and 2015, of the 319 patients who underwent LDLT at our institute, 12 were indicated for unresectable HBL. Three patients with unresectable HBL who underwent LDLT from ABO-I donors are included in this study. Immunosuppression consisted of a standard regime of tacrolimus and low-dose steroids as in ABO compatible/identical LDLT. No additional preoperative therapies for B-cell depletion were used. Absolute lymphocyte counts, lymphocyte subsets (including CD20+ B cells, CD3+CD4+ T cells and CD3+CD8+ T cells), and anti-ABO blood type isoagglutinin titers were measured before LDLT and postoperatively. The median age at diagnosis was 19 months (range, 3-31 months). The median follow-up was seven months (range, 6-15 months). The median interval from the last NAC to LDLT was 33 days (range, 25-52 days). The median interval from LDLT to adjuvant chemotherapy was 28 days (range, 22-36 days). The counts of CD20+ B cells before LDLT were depleted to median 5 cells/mm(3) (range, 0-6 cells/mm(3)). There was a transient rebound in the CD20+ B cell counts on day seven (maximum of 82 cells/mm(3)) followed by a decline starting at 14 days after LDLT that was sustained for the duration of adjuvant chemotherapy. Anti-ABO blood type isoagglutinin titers were lowered to between 1:1 and 1:16 before LDLT and remained low for the duration of follow-up in this study. All of the three patients remained in good health without either acute cellular or AMR after LDLT. The B-cell depletion that occurs after cisplatin-based chemotherapy for HBL may help accomplish safe ABO-I LDLT in children without the use of additional conditioning regimens for prevention of AMR.

  55. 有機酸代謝異常症(メチルマロン酸血症、プロピオン酸血症)における生体肝移植

    佐々木 健吾, 福田 晃也, 松波 昌寿, 内田 孟, 重田 孝信, 金澤 寛之, 中澤 温子, 堀川 玲子, 笠原 群生

    移植　50　(4-5)　529-529　2015年10月

    出版者・発行元： (一社)日本移植学会

    ISSN：0578-7947

    eISSN：2188-0034

  56. Donor double common bile duct in living donor liver transplantation. 国際誌 査読有り

    Hajime Uchida, Akinari Fukuda, Kengo Sasaki, Mikiko Miyasaka, Osamu Miyazaki, Shunsuke Nosaka, Mureo Kasahara

    Transplant international : official journal of the European Society for Organ Transplantation　28　(10)　1233-4　2015年10月

    DOI： 10.1111/tri.12619 　

  57. A central approach to splenorenal shunt in pediatric living donor liver transplantation. 国際誌 査読有り

    Hajime Uchida, Akinari Fukuda, Matsunami Masatoshi, Kengo Sasaki, Takanobu Shigeta, Hiroyuki Kanazawa, Atsuko Nakazawa, Osamu Miyazaki, Shunsuke Nosaka, Seisuke Sakamoto, Mureo Kasahara

    Pediatric transplantation　19　(6)　E142-5　2015年9月

    DOI： 10.1111/petr.12543 　

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    The management of LSRS is a crucial problem to ensure a sufficient PV flow during pediatric LT. Although several techniques have been indicated to solve this problem, a more appropriate approach to LSRS is still needed in pediatric LT. We herein present a modified surgical approach to the ligation of LSRS via the left side of the IVC for a nine-month-old boy with severe portal hypertension and a history of Kasai portoenterostomy. LSRS was identified and exposed through the left side of the IVC and the dorsal surface of the pancreas from the superior side of the body of the pancreas. The post-operative course was uneventful with an excellent PV flow. The central approach for the ligation of LSRS is worth considering as an alternative procedure for a patient with collateral vessels and a history of multiple laparotomies.

  58. Successful living domino liver transplantation in a child with protein C deficiency. 国際誌 査読有り

    Masatoshi Matsunami, Akira Ishiguro, Akinari Fukuda, Kengo Sasaki, Hajime Uchida, Takanobu Shigeta, Hiroyuki Kanazawa, Seisuke Sakamoto, Motoki Ohta, Hisaya Nakadate, Reiko Horikawa, Atsuko Nakazawa, Mika Ishige, Koichi Mizuta, Mureo Kasahara

    Pediatric transplantation　19　(3)　E70-4　2015年5月

    DOI： 10.1111/petr.12446 　

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    PC is produced in the liver and inhibits blood coagulation by catalyzing active factors V and VIII. PC deficiency causes abnormal blood clotting that is difficult to regulate by anticoagulative treatments. Four reports of PC deficiency treated with LTx have been published; however, no report of DLT as a therapy for PC deficiency is available. We describe a case of a 23-month-old girl who received DLT for compound heterozygous PC deficiency. Her PC activity was below 5%. She developed intracranial lesion and frequent refractory purpura fulminans. Both her parents had heterozygous mutations of PC genes and were excluded as living donors. Furthermore, she was a low priority on the waiting list of deceased-donor transplantation. We performed living DLT using the liver from a patient with MSUD. Activated PC concentrate safely supported the perioperative period. After DLT, she maintained normal PC activities and BCAA levels. This is the first case of PC deficiency successfully treated by living DLT with MSUD. We propose that DLT using liver from patients with MSUD is a treatment option for PC deficiency.

  59. The degree of spleen stiffness measured on acoustic radiation force impulse elastography predicts the severity of portal hypertension in patients with biliary atresia after portoenterostomy. 国際誌 査読有り

    Hajime Uchida, Seisuke Sakamoto, Megumi Kobayashi, Takanobu Shigeta, Masatoshi Matsunami, Kengo Sasaki, Hiroyuki Kanazawa, Akinari Fukuda, Yutaka Kanamori, Mikiko Miyasaka, Shunsuke Nosaka, Naoki Kawagishi, Mureo Kasahara

    Journal of pediatric surgery　50　(4)　559-64　2015年4月

    DOI： 10.1016/j.jpedsurg.2014.12.026 　

    詳細を見る 詳細を閉じる

    BACKGROUND/PURPOSE: Acoustic radiation focus impulse (ARFI) elastography is a new method for assessing the degree of tissue stiffness. We herein evaluated the degree of spleen stiffness (SS) using ARFI elastography in patients with biliary atresia (BA) after Kasai portoenterostomy (KPE). METHODS: We retrospectively collected the liver stiffness (LS) and SS values on ARFI elastography from 43 patients undergoing KPE between September 2010 and November 2013. We analyzed the correlations between these values and variables related to the severity of liver dysfunction and portal hypertension (PHT). The data were expressed as the standard deviation score (z-score) relative to the previously reported normal values for the patient's age. RESULTS: The SS value was significantly associated with the spleen diameter and development of collateral vessels, in comparison to the LS value. Interestingly, there was a significant correlation between SS value and the portal vein (PV) diameter. Thirty patients (69.8%) consequently underwent LT; these patients showed higher SS values and smaller PV diameters than the patients monitored without LT. CONCLUSIONS: The degree of SS measured on ARFI elastography can be used to predict the severity of PHT in BA patients after KPE.

  60. Evaluation of the immune function assay in pediatric living donor liver transplantation. 国際誌 査読有り

    Akinari Fukuda, Ken-Ichi Imadome, Seisuke Sakamoto, Takanobu Shigeta, Hajime Uchida, Masatoshi Matsunami, Kengo Sasaki, Hiroyuki Kanazawa, Fuyuko Kawano, Atsuko Nakazawa, Shigeyoshi Fujiwara, Mureo Kasahara

    Pediatric transplantation　19　(2)　144-52　2015年3月

    DOI： 10.1111/petr.12402 　

    詳細を見る 詳細を閉じる

    The immune function (ImmuKnow) assay is a measure of cell-mediated immunity based on the peripheral CD4+ T cell ATP activity. The efficacy of ImmuKnow in pediatric LDLT is not well documented. The aim of this study was to assess the correlations between the ImmuKnow and the clinical status in pediatric LDLT recipients. A total of 716 blood samples were obtained from 60 pediatric LDLT recipients (one month to 16 yr of age). The recipient's status was classified as follows: stable, infection, or rejection. The ImmuKnow values in the pediatric LDLT recipients with a clinically stable status had a lower immune response (IQR 85-297 ATP ng/mL) than that previously reported in adults. Meanwhile, the ImmuKnow values of the stable patients were not correlated with age. Furthermore, a significant difference was found in the ImmuKnow values between the bacterial or fungal infection and stable groups, but not between the CMV or EBV infection and stable groups. The ImmuKnow levels in the pediatric LDLT were lower than those observed in the adult LDLT. The proposed reference value is between 85 and 297 ATP ng/mL in pediatric LDLT recipients. We conclude that the ImmuKnow assay could be helpful for monitoring pediatric LDLT recipients with bacterial or fungal infections.

  61. Two-step transplantation for primary hyperoxaluria: a winning strategy to prevent progression of systemic oxalosis in early onset renal insufficiency cases. 国際誌 査読有り

    Kengo Sasaki, Seisuke Sakamoto, Hajime Uchida, Takanobu Shigeta, Masatoshi Matsunami, Hiroyuki Kanazawa, Akinari Fukuda, Atsuko Nakazawa, Mai Sato, Shuichi Ito, Reiko Horikawa, Tadashi Yokoi, Noriyuki Azuma, Mureo Kasahara

    Pediatric transplantation　19　(1)　E1-6　2015年2月

    DOI： 10.1111/petr.12376 　

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    Several transplant strategies for PH1 have been proposed, and LT is performed to correct the metabolic defects. The patients with PH1 often suffer from ESRD and require simultaneous LKT, which leads to a long wait due to the shortage of suitable organ donors. Five patients with PH1 underwent LDLT at our institute. Three of the five patients were under dialysis before LDLT, while the other two patients were categorized as CKD stage 3. An isolated LDLT was successfully performed in all but our first case, who had complicated postoperative courses and consequently died due to sepsis after retransplantation. The renal function of the patients with CKD stage 3 was preserved after LDLT. On the other hand, our second case with ESRD underwent successful LDKT six months after LDLT, and our infant case is waiting for the subsequent KT without any post-LDLT complications after the early establishment of PD. In conclusion, a two-step transplant strategy may be needed as a life-saving option for patients with PH1 and may be possible even in small infants with systemic oxalosis. While waiting for a subsequent KT, an early resumption of PD should be considered from the perspective of the long-term requirement of RRT.

  62. 肝細胞移植の展望 ̶新生児期発症の尿素サイクル異常への移植経験から ̶

    重田 孝信, 絵野沢 伸, 松波 昌寿, 佐々木 健吾, 内田 孟, 金澤 寛之, 福田 晃也, 堀川 玲子, 野坂 俊介, 笠原 群生

    Organ Biology　22　(2)　171-175　2015年

    出版者・発行元： 一般社団法人 日本臓器保存生物医学会

    DOI： 10.11378/organbio.22.171 　

    ISSN：1340-5152

    詳細を見る 詳細を閉じる

    Hepatocyte transplantation (HT) is attractive option for urea cycle disorder and acute liver failure. HT has the benefit of non-invasive treatment, availability of hepatocyte isolated from marginal donors and cryopreserved hepatocytes at the time of need. On the other hand, the disadvantages of HT are injury of hepatocytes after thawing, difficulty of monitoring acute cellular rejection after HT, and limited donor source for HT. We experienced HT for neonatal ornithine transcarbamylase deficiency patient using hepatocytes from living donor for the fi rst case in the world. In our study, hepatocytes were isolated from the redundant liver of reduced left lateral segment graft from living donor. The quality of hepatocytes from living donor is better than that from deceased donor. The patient underwent living donor liver transplantation from his mother 5 months after HT.

  63. Technical refinement in living-donor liver transplantation for hepatoblastoma with main portal vein tumor thrombosis - a pullout technique. 国際誌 査読有り

    Hiroyuki Kanazawa, Seisuke Sakamoto, Masatoshi Matsunami, Kengo Sasaki, Hajime Uchida, Takanobu Shigeta, Akinari Fukuda, Kimikazu Matsumoto, Atsuko Nakazawa, Ryuhei Tanaka, Mureo Kasahara

    Pediatric transplantation　18　(8)　E266-9　2014年12月

    DOI： 10.1111/petr.12357 　

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    We present a case of a two-yr-old boy diagnosed with HBT with complete main PVTT. HBT was located in the bilateral lobe with PVTT involving the confluence of the SMV and the SpV. Cisplatin-based neoadjuvant chemotherapy was delivered; main tumor shrank and AFP levels decreased to below one hundredth. However, PVTT remained in the bilateral portal branches to the main trunk of PV. We describe the technical details of the portal venous tumor thrombectomy that was succeeded by a LDLT. The patient remained healthy 2.5 yr after LDLT, showing good patency of the PV with no evidence of recurrence of tumor.

  64. Basiliximab treatment for steroid-resistant rejection in pediatric patients following liver transplantation for acute liver failure. 国際誌 査読有り

    Takanobu Shigeta, Seisuke Sakamoto, Hajime Uchida, Kengo Sasaki, Ikumi Hamano, Hiroyuki Kanazawa, Akinari Fukuda, Toshinao Kawai, Masafumi Onodera, Atsuko Nakazawa, Mureo Kasahara

    Pediatric transplantation　18　(8)　860-7　2014年12月

    DOI： 10.1111/petr.12373 　

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    An IL-2 receptor antagonist, basiliximab, decreases the frequency of ACR in liver transplant (LT) recipients as induction therapy. The aim of this study was to evaluate the effectiveness of basiliximab against SRR as rescue therapy in pediatric LT patients with ALF. Forty pediatric ALF patients underwent LT between November 2005 and July 2013. Among them, seven patients suffering from SRR were enrolled in this study. The median age at LT was 10 months (6-12 months). SRR was defined as the occurrence of refractory rejection after more than two courses of steroid pulse therapy. Basiliximab was administered to all patients. The withdrawal of steroids without deterioration of the liver function was achieved in six patients treated with basiliximab therapy without patient mortality, although one patient developed graft loss and required retransplantation for veno-occlusive disease. The pathological examinations of liver biopsies in the patients suffering from SRR revealed severe centrilobular injuries, particularly fibrosis within one month after LT. We demonstrated the effectiveness and safety of rescue therapy consisting of basiliximab for SRR in pediatric LT recipients with ALF.

  65. Technical considerations of living donor hepatectomy of segment 2 grafts for infants. 国際誌 査読有り

    Seisuke Sakamoto, Hiroyuki Kanazawa, Takanobu Shigeta, Hajime Uchida, Kengo Sasaki, Ikumi Hamano, Akinari Fukuda, Shunsuke Nosaka, Hiroto Egawa, Mureo Kasahara

    Surgery　156　(5)　1232-7　2014年11月

    DOI： 10.1016/j.surg.2014.05.003 　

    詳細を見る 詳細を閉じる

    BACKGROUND: The selection of an adequate graft to mitigate the problems associated with a large-for-size graft is essential to ensure the success of liver transplantation for smaller children. Reduced left lateral segment (LLS) grafts have been introduced to overcome this issue. METHODS: Five infants underwent living donor liver transplantation (LDLT) with segment 2 grafts. In the preoperative assessment, the graft-to-recipient weight ratio (GRWR) and the ratio of the thickness of the donor LLS were used as a reference index for graft size matching, and a 3-dimensional (3D) computer-generated model of the donor liver was used for the analysis of the intrahepatic vasculature. During the donor operation, the relevant portal vein branches feeding to the reduced part of segment 3 were first exposed and divided, and then the parenchymal transection was performed. RESULTS: Segment 2 grafts were selected in 3 cases and reduced segment 2 grafts were selected in the other 2 cases. The graft reduction was achieved with 46.6 ± 8.2% of the actual LLS, and thus the GRWR was reduced from 5.33 ± 2.09% to 2.70 ± 0.82%. The actual graft thickness was reduced by approximately half after the graft reduction. Primary abdominal closure was performed in all of the recipients. No surgical complications occurred in any of the donors or recipients. CONCLUSION: A segment 2 graft could be a valuable option for graft type selection in LDLT for smaller children. Precise planning using a 3D computer-generated model of the donor liver and meticulous operative procedures are necessary to obtain a viable graft.

  66. Hepatic artery reconstruction preserving the pancreaticoduodenal arcade in pediatric liver transplantation with celiac axis compression syndrome: report of a case. 国際誌 査読有り

    Hajime Uchida, Seisuke Sakamoto, Masatoshi Matsunami, Kengo Sasaki, Takanobu Shigeta, Hiroyuki Kanazawa, Akinari Fukuda, Atsuko Nakazawa, Osamu Miyazaki, Shunsuke Nosaka, Mureo Kasahara

    Pediatric transplantation　18　(7)　E232-5　2014年11月

    DOI： 10.1111/petr.12329 　

    詳細を見る 詳細を閉じる

    CACS is rare, although it has been reported to be a potential risk factor for hepatic artery thrombosis following LT. We herein present the case of a 14-yr-old male with stenosis of the origin of the celiac trunk. Preoperative CT and color ultrasonography showed narrowing of the proximal celiac artery. The patient underwent DDLT with standard arterial reconstruction without dividing the gastroduodenal artery. His postoperative course was uneventful, with an excellent hepatic artery flow on Doppler ultrasonography. Applying a meticulous preoperative evaluation and the appropriate surgical technique is crucial in patients with CACS.

  67. Clinical Outcomes and Evaluation of the Quality of Life of Living Donors for Pediatric Liver Transplantation: A Single-Center Analysis of 100 Donors 査読有り

    A. Fukuda, S. Sakamoto, T. Shigeta, H. Uchida, I. Hamano, K. Sasaki, H. Kanazawa, D. L. Loh, N. Kakee, A. Nakazawa, M. Kasahara

    TRANSPLANTATION PROCEEDINGS　46　(5)　1371-1376　2014年6月

    DOI： 10.1016/j.transproceed.2013.12.054 　

    ISSN：0041-1345

    eISSN：1873-2623

  68. Central pontine myelinolysis following pediatric living donor liver transplantation: a case report and review of literature. 国際誌 査読有り

    Hajime Uchida, Seisuke Sakamoto, Kengo Sasaki, Ikumi Hamano, Takanobu Shigeta, Hiroyuki Kanazawa, Akinari Fukuda, Shunsuke Nosaka, Masaya Kubota, Mureo Kasahara

    Pediatric transplantation　18　(4)　E120-3　2014年6月

    DOI： 10.1111/petr.12255 　

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    CPM is one of the most serious neurological complications that can occur after OLT and is characterized by symmetrical demyelinization in the basis pontis. The etiology of CPM remains unclear, although the rapid correction of the serum sodium and CNI concentrations may be associated with the development of CPM. With recent advances in MRI technology, early diagnosis of CPM has become possible. Here, we present the case of a five-yr-old female who developed CNI-associated CPM after undergoing LDLT. A decreased level of consciousness and dysphasia was noted one wk after LDLT, and MRI revealed findings compatible with a diagnosis of CPM. The patient fully recovered from the neurological deficits related to CPM following the switch from the CNI to sirolimus. We propose MRI to be promptly considered for patients with abnormal neurological findings, together with the substitution of CNI with an mTOR inhibitor as a management regimen for CNI-related CPM.

  69. Impact of the current organ allocation system for deceased donor liver transplantation on the outcomes of pediatric recipients: a single center experience in Japan. 国際誌 査読有り

    Seisuke Sakamoto, Hajime Uchida, Ikumi Hamano, Takanobu Shigeta, Kengo Sasaki, Hiroyuki Kanazawa, Akinari Fukuda, Mureo Kasahara

    Pediatric surgery international　29　(11)　1109-14　2013年11月

    DOI： 10.1007/s00383-013-3381-x 　

    詳細を見る 詳細を閉じる

    PURPOSE: The aim of this study was to analyze the outcomes of children added to the waiting list for deceased donor liver transplantation (DDLT) and the results of DDLT in a single Japanese center. METHODS: Forty-seven children were listed on the organ allocation system for DDLT. The priority points related to the medical status of each patient were evaluated and stratified into four categories; 10, 8, 6, and 3 points. The clinical data were collected from the medical records, and the outcomes were analyzed. RESULTS: There were 10 priority points in 25 patients, 6 points in 13 and 3 points in 9. Ten recipients (21.3 %); 7 patients with 10 points and 3 patients with 6 points, underwent DDLT. Seven out of the 10 recipients received split/reduced liver grafts. The surgical complications consisted of biliary stricture, hepatic venous outflow obstruction, intraabdominal abscess and intraabdominal bleeding. Two recipients, who were critically-ill before DDLT, died due to sepsis. The one-year graft survival rate was 70.0 %, with a median follow-up period of 6.4 months. CONCLUSION: The initial experience with pediatric DDLT in our series was satisfactory. Split LT of deceased donor organs may have the potential to resolve the serious organ shortage in Japan.

  70. [Deceased donor liver transplantation receiving a liver from a child under six years old: an experience of organ retrieval from a pediatric donor in Japan]. 査読有り

    Ikumi Hamano, Seisuke Sakamoto, Akinari Fukuda, Hajime Uchida, Kengo Sasaki, Takanobu Shigeta, Hiroyuki Kanazawa, Atsuko Nakazawa, Mureo Kasahara, Yasuhiro Ogura, Shinji Uemoto

    Nihon Geka Gakkai zasshi　114　(6)　340-4　2013年11月

    ISSN：0301-4894

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    We report a first pediatric liver transplantation from a brain-dead donor under 6-year-old in Japan. A 9-month-old girl suffered from graft failure after living donor liver transplantation for biliary atresia. The deceased donor liver transplantation (DDLT) from under 6-year-old was performed. It was important to select appropriate surgical devices for the pediatric organ recovery based on the preoperative evaluation. Sufficient vessel grafts were procured because of difficult vascular reconstruction. She discharged on 172 days after DDLT. There have been few cases of pediatric organ donation in Japan. Therefore we should make careful preparation for both of donor and recipient.

︎全件表示 ︎最初の5件までを表示

MISC 148

  1. 当院における肝移植レシピエント、生体ドナー候補者の後方視的検討

    佐々木 健吾, 金井 哲史, 齋藤 純健, 松村 宗幸, 宮澤 恒持, 柏舘 俊明, 藤尾 淳, 戸子台 和哲, 宮城 重人, 亀井 尚, 海野 倫明

    移植　56　(総会臨時)　O2-1　2021年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  2. 移植後EBウイルス感染症 当院における生体肝移植後リンパ増殖性疾患 成人および小児症例の解析

    松村 宗幸, 宮城 重人, 戸子台 和哲, 柏舘 俊明, 藤尾 淳, 宮澤 恒持, 佐々木 健吾, 斎藤 純健, 金井 哲史, 海野 倫明, 亀井 尚

    移植　56　(総会臨時)　CWS2-4　2021年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  3. 移植外科医・コーディネーターの働き方改革(互助制度を視野に入れて) 東北大学における脳死臓器摘出互助化の推進と摘出手技教育プログラムの構築 肝膵腎小腸の摘出チームにおける試み

    宮澤 恒持, 宮城 重人, 戸子台 和哲, 柏舘 俊明, 藤尾 淳, 佐々木 健吾, 松村 宗幸, 齋藤 純健, 金井 哲史, 亀井 尚, 海野 倫明

    移植　56　(総会臨時)　CSY2-5　2021年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  4. 生体肝ドナーの安全性向上(腹腔鏡下手術の適応も含む) 当科の生体肝移植ドナーへの安全性と低侵襲性への取り組み

    藤尾 淳, 宮城 重人, 戸子台 和哲, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 斎藤 純健, 金井 哲史, 海野 倫明, 亀井 尚

    移植　56　(総会臨時)　SSY6-3　2021年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  5. 悪性腫瘍に対する生体肝移植-肝細胞癌に対する適応拡大、肝門部領域胆管癌、転移性肝癌 局所進行肝門部領域胆管癌に対する肝移植適応の検討

    宮城 重人, 戸子台 和哲, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 齋藤 純健, 金井 哲史, 亀井 尚, 海野 倫明

    移植　56　(総会臨時)　SWS5-1　2021年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  6. 当院における血液型不適合肝移植の現状

    柏舘 俊明, 宮城 重人, 戸子台 和哲, 藤尾 淳, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 齋藤 純健, 金井 哲史, 亀井 尚, 海野 倫明

    移植　56　(総会臨時)　P2-9　2021年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  7. 肝移植における慢性抗体関連拒絶の意義と治療介入の試み

    戸子台 和哲, 宮城 重人, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 齋藤 純健, 海野 倫明, 後藤 昌史, 亀井 尚

    移植　56　(総会臨時)　P2-10　2021年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  8. 生体移植における家族ケア 生体肝移植におけるドナーケア

    宮城 重人, 戸子台 和哲, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 亀井 尚, 海野 倫明

    移植　56　(総会臨時)　CWS7-4　2021年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  9. 肝移植後長期経過症例における血清Mac-2結合蛋白蛋白糖鎖修飾異性体濃度と移植肝線維化の関連に関する検討

    戸子台 和哲, 宮城 重人, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 亀井 尚, 海野 倫明

    肝臓　62　(Suppl.2)　A537-A537　2021年9月

    出版者・発行元： (一社)日本肝臓学会

    ISSN： 0451-4203

    eISSN： 1881-3593

  10. 本邦における膵臓移植・膵島移植の位置づけ 当院における膵臓移植・膵島移植の位置づけ

    宮城 重人, 後藤 昌史, 戸子台 和哲, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 亀井 尚, 海野 倫明

    膵臓　36　(3)　A269-A269　2021年8月

    出版者・発行元： (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  11. 多施設臨床研究国内第一例目となる、酸素化灌流保存装置を使用した心停止ドナー腎移植の報告

    宮城 重人, 柏舘 俊明, 西牧 宏泰, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 佐々木 健吾, 亀井 尚, 海野 倫明, 松野 直徒

    移植　56　(1)　69-74　2021年7月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  12. 肝門部領域胆管癌に対する肝移植-for vs against- 局所進行肝門部領域胆管癌に対する肝移植の意義

    宮城 重人, 戸子台 和哲, 中西 渉, 藤尾 淳, 柏舘 俊明, 佐々木 健吾, 益田 邦洋, 中川 圭, 森川 孝則, 大沼 忍, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　DB-1　2021年4月

    出版者・発行元： (一社)日本外科学会

  13. 当科での肝・膵移植における術前リツキシマブ脱感作療法の成績と課題

    柏舘 俊明, 宮城 重人, 戸子台 和哲, 中西 渉, 藤尾 淳, 佐々木 健吾, 西村 隆一, 小笠原 弘之, 大沼 忍, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　SF-5　2021年4月

    出版者・発行元： (一社)日本外科学会

  14. 当院における小児肝移植の現状と今後の課題

    佐々木 健吾, 宮城 重人, 戸子台 和哲, 中西 渉, 藤尾 淳, 柏舘 俊明, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　PS-5　2021年4月

    出版者・発行元： (一社)日本外科学会

  15. 東北地方における臓器提供増加にむけた取り組みと課題について 移植外科医の立場から

    藤尾 淳, 宮城 重人, 小笠原 弘之, 佐々木 健吾, 柏舘 俊明, 中西 渉, 西村 隆一, 戸子台 和哲, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　PS-7　2021年4月

    出版者・発行元： (一社)日本外科学会

  16. 脂肪肝合併肝移植ドナー候補に対する栄養療法

    中西 渉, 宮城 重人, 戸子台 和哲, 西村 隆一, 藤尾 淳, 佐々木 健吾, 宮崎 勇希, 笹嶋 秀憲, 海野 倫明, 亀井 尚

    学会誌JSPEN　2　(Suppl.1)　1344-1344　2020年11月

    出版者・発行元： (一社)日本臨床栄養代謝学会

    eISSN： 2434-4966

  17. 肝移植におけるdnDSAの危険因子と免疫抑制療法再強化によるDSA抑制効果の検証

    戸子台 和哲, 宮城 重人, 中西 渉, 藤尾 淳, 柏舘 俊明, 佐々木 健吾, 菖野 佳浩, 太田 嶺人, 小笠原 弘之, 後藤 昌史, 亀井 尚, 海野 倫明

    移植　55　(総会臨時)　240-240　2020年10月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  18. 高齢ドナー高齢レシピエントの肝移植術後経過における危険性の検討

    宮城 重人, 戸子台 和哲, 中西 渉, 藤尾 淳, 柏舘 俊明, 佐々木 健吾, 菖野 佳浩, 太田 嶺人, 亀井 尚, 海野 倫明

    移植　55　(総会臨時)　251-251　2020年10月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  19. 当科のアルコール関連肝不全における肝移植後経過に関する検討

    菖野 佳浩, 宮城 重人, 戸子台 和哲, 中西 渉, 藤尾 淳, 柏舘 俊明, 佐々木 健吾, 太田 嶺人, 海野 倫明, 亀井 尚

    移植　55　(総会臨時)　278-278　2020年10月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  20. 急性肝不全昏睡型の肝移植成績および予後不良因子の検討

    宮城 重人, 戸子台 和哲, 中西 渉, 藤尾 淳, 柏舘 俊明, 佐々木 健吾, 菖野 佳浩, 太田 嶺人, 亀井 尚, 海野 倫明

    移植　55　(総会臨時)　280-280　2020年10月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  21. Renoportal再建を施行した生体肝移植後挙上空腸静脈瘤から消化管出血を来した一例

    中西 渉, 宮城 重人, 戸子台 和哲, 藤尾 淳, 柏館 俊明, 佐々木 健吾, 菖野 佳浩, 太田 嶺人, 海野 倫明, 亀井 尚

    移植　55　(総会臨時)　346-346　2020年10月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  22. 小児肝移植症例における抗ドナーHLA抗体とグラフト線維化の関連

    柿崎 裕太, 戸子台 和哲, 福岡 健吾, 佐々木 健吾, 藤尾 淳, 西村 隆一, 中西 渉, 宮城 重人

    日本小児栄養消化器肝臓学会雑誌　33　(2)　141-141　2019年12月

    出版者・発行元： (一社)日本小児栄養消化器肝臓学会

    ISSN： 1346-9037

  23. 東北大学病院における小児肝移植の現状と今後の課題

    佐々木 健吾, 宮城 重人, 笹嶋 秀憲, 柿崎 裕太, 福岡 健吾, 藤尾 淳, 西村 隆一, 中西 渉, 戸子台 和哲, 亀井 尚, 海野 倫明

    日本小児栄養消化器肝臓学会雑誌　33　(2)　141-141　2019年12月

    出版者・発行元： (一社)日本小児栄養消化器肝臓学会

    ISSN： 1346-9037

  24. Bile acid amidation defects症例におけるグルクロン酸抱合型胆汁酸の動態について

    佐々木 健吾, 福田 晃也, 武田 昌寛, 内田 孟, 平田 義弘, 阪本 靖介, 入江 恵理, 義岡 孝子, 全 陽, 岩間 達, 乾 あやの, 藤澤 知雄, 笠原 群生

    日本小児栄養消化器肝臓学会雑誌　33　(2)　148-149　2019年12月

    出版者・発行元： (一社)日本小児栄養消化器肝臓学会

    ISSN： 1346-9037

  25. 小児肝移植症例における抗ドナーHLA抗体とグラフト線維化の関連

    柿崎 裕太, 戸子台 和哲, 福岡 健吾, 佐々木 健吾, 藤尾 淳, 西村 隆一, 中西 渉, 宮城 重人

    日本小児栄養消化器肝臓学会雑誌　33　(2)　141-141　2019年12月

    出版者・発行元： 日本小児栄養消化器肝臓学会

    ISSN： 1346-9037

  26. 東北大学病院における小児肝移植の現状と今後の課題

    佐々木 健吾, 宮城 重人, 笹嶋 秀憲, 柿崎 裕太, 福岡 健吾, 藤尾 淳, 西村 隆一, 中西 渉, 戸子台 和哲, 亀井 尚, 海野 倫明

    日本小児栄養消化器肝臓学会雑誌　33　(2)　141-141　2019年12月

    出版者・発行元： 日本小児栄養消化器肝臓学会

    ISSN： 1346-9037

  27. エキノコッカス症による多発腹腔内包虫嚢胞の1例

    西牧 宏泰, 中西 渉, 宮城 重人, 戸子台 和哲, 西村 隆一, 藤尾 淳, 佐々木 健吾, 内藤 剛, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　80　(増刊)　868-868　2019年10月

    出版者・発行元： 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  28. 血液型不適合肝臓移植の現状と課題 心停止ドナー肝グラフトの臓器再生の現状と展望

    宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 佐々木 健吾, 宮崎 勇希, 笹嶋 秀憲, 後藤 昌史, 亀井 尚, 海野 倫明

    移植　54　(総会臨時)　184-184　2019年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

  29. 肝移植後胆管空腸吻合部狭窄に対し、ブロッケンブロー針を用いて胆管空腸の瘻孔化に成功した一例

    佐々木 健吾, 宮城 重人, 笹嶋 秀憲, 宮崎 勇希, 藤尾 淳, 西村 隆一, 中西 渉, 戸子台 和哲, 大田 英揮, 高瀬 圭, 亀井 尚, 海野 倫明

    移植　54　(総会臨時)　200-200　2019年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

  30. 補体結合性ドナー特異的抗HLA抗体のグラフト肝への影響

    戸子台 和哲, 宮城 重人, 中西 渉, 西村 隆一, 藤尾 淳, 佐々木 健吾, 宮崎 勇希, 笹嶋 秀憲, 後藤 昌史, 海野 倫明, 亀井 尚

    移植　54　(総会臨時)　226-226　2019年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

  31. エコー上指摘された生体肝移植後早期門脈ガス像の臨床的意義

    中西 渉, 宮城 重人, 戸子台 和哲, 西村 隆一, 藤尾 淳, 佐々木 健吾, 宮崎 勇希, 笹嶋 秀憲, 内藤 剛, 海野 倫明, 後藤 昌史, 亀井 尚

    移植　54　(総会臨時)　290-290　2019年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

  32. 血液型不適合肝臓移植の現状と課題 心停止ドナー肝グラフトの臓器再生の現状と展望

    宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 佐々木 健吾, 宮崎 勇希, 笹嶋 秀憲, 後藤 昌史, 亀井 尚, 海野 倫明

    移植　54　(総会臨時)　184-184　2019年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  33. 肝移植後胆管空腸吻合部狭窄に対し、ブロッケンブロー針を用いて胆管空腸の瘻孔化に成功した一例

    佐々木 健吾, 宮城 重人, 笹嶋 秀憲, 宮崎 勇希, 藤尾 淳, 西村 隆一, 中西 渉, 戸子台 和哲, 大田 英揮, 高瀬 圭, 亀井 尚, 海野 倫明

    移植　54　(総会臨時)　200-200　2019年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  34. 補体結合性ドナー特異的抗HLA抗体のグラフト肝への影響

    戸子台 和哲, 宮城 重人, 中西 渉, 西村 隆一, 藤尾 淳, 佐々木 健吾, 宮崎 勇希, 笹嶋 秀憲, 後藤 昌史, 海野 倫明, 亀井 尚

    移植　54　(総会臨時)　226-226　2019年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  35. エコー上指摘された生体肝移植後早期門脈ガス像の臨床的意義

    中西 渉, 宮城 重人, 戸子台 和哲, 西村 隆一, 藤尾 淳, 佐々木 健吾, 宮崎 勇希, 笹嶋 秀憲, 内藤 剛, 海野 倫明, 後藤 昌史, 亀井 尚

    移植　54　(総会臨時)　290-290　2019年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  36. 高度心機能低下を有するWilson病患者に対し、肝移植後、大動脈内バルーンパンピングを使用し救命した一例

    佐々木 健吾, 宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 福岡 健吾, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　74回　P195-4　2019年7月

    出版者・発行元： (一社)日本消化器外科学会

  37. 腎機能障害を有する患者の周術期管理 Chronic kidney diseaseを伴う肝細胞癌患者に対する肝切除術 周術期合併症への影響

    西村 隆一, 宮城 重人, 戸子台 和哲, 中西 渉, 藤尾 淳, 佐々木 健吾, 福岡 健吾, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　74回　WS16-7　2019年7月

    出版者・発行元： (一社)日本消化器外科学会

  38. 小児生体肝移植術後の晩期門脈合併症に対する治療戦略

    藤尾 淳, 宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 佐々木 健吾, 福岡 健吾, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　74回　P198-6　2019年7月

    出版者・発行元： (一社)日本消化器外科学会

  39. 胆道閉鎖症葛西術後キャリーオーバー症例を含む、複数開腹歴のある症例に対する肝移植

    宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 福岡 健吾, 佐々木 健吾, 柿崎 裕太, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　74回　O22-2　2019年7月

    出版者・発行元： (一社)日本消化器外科学会

  40. 肝切除における術中出血が与える影響の栄養学的パラメータを用いた解析

    中西 渉, 宮城 重人, 戸子台 和哲, 西村 隆一, 藤尾 淳, 佐々木 健吾, 福岡 健吾, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　74回　P193-2　2019年7月

    出版者・発行元： (一社)日本消化器外科学会

  41. 高度心機能低下を有するWilson病患者に対し、肝移植後、大動脈内バルーンパンピングを使用し救命した一例

    佐々木 健吾, 宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 福岡 健吾, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　74回　P195-4　2019年7月

    出版者・発行元： (一社)日本消化器外科学会

  42. 腎機能障害を有する患者の周術期管理 Chronic kidney diseaseを伴う肝細胞癌患者に対する肝切除術 周術期合併症への影響

    西村 隆一, 宮城 重人, 戸子台 和哲, 中西 渉, 藤尾 淳, 佐々木 健吾, 福岡 健吾, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　74回　WS16-7　2019年7月

    出版者・発行元： (一社)日本消化器外科学会

  43. 小児生体肝移植術後の晩期門脈合併症に対する治療戦略

    藤尾 淳, 宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 佐々木 健吾, 福岡 健吾, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　74回　P198-6　2019年7月

    出版者・発行元： (一社)日本消化器外科学会

  44. 胆道閉鎖症葛西術後キャリーオーバー症例を含む、複数開腹歴のある症例に対する肝移植

    宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 福岡 健吾, 佐々木 健吾, 柿崎 裕太, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　74回　O22-2　2019年7月

    出版者・発行元： (一社)日本消化器外科学会

  45. 多職種介入によるNSTの現状と問題点

    中西 渉, 宮城 重人, 戸子台 和哲, 西村 隆一, 佐々木 健吾, 福岡 健吾, 熊田 博之, 石田 孝宣, 内藤 剛, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　119回　PS-012　2019年4月

    出版者・発行元： (一社)日本外科学会

  46. 当科における12歳未満の小児生体肝移植の成績について

    藤尾 淳, 宮城 重人, 中西 史, 戸子台 和哲, 中西 渉, 西村 隆一, 佐々木 健吾, 福岡 健吾, 熊田 博之, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　PS-088　2019年4月

    出版者・発行元： (一社)日本外科学会

  47. 肝・膵粘液性嚢胞腫瘍における卵巣様間質でのステロイドホルモン合成動態についての免疫組織化学的検討

    熊田 博之, 宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 佐々木 健吾, 福岡 健吾, 内藤 剛, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　119回　PS-177　2019年4月

    出版者・発行元： (一社)日本外科学会

  48. 甲状腺髄様癌が傍神経節腫に腫瘍内転移したMEN2Bの一例

    菖野 佳浩, 戸子台 和哲, 西村 隆一, 中西 渉, 藤尾 淳, 佐々木 健吾, 福岡 健吾, 柿崎 裕太, 宮城 重人, 亀井 尚, 石田 孝宣, 海野 倫明, 山崎 有人, 笹野 公伸

    日本内分泌学会雑誌　95　(1)　497-497　2019年4月

    出版者・発行元： (一社)日本内分泌学会

    ISSN： 0029-0661

  49. 進行肝門部胆管癌に対する動門脈合併切除の成績及び血管内皮保護を目的とした超音波モニタリング術後管理法の有用性

    宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 福岡 健吾, 熊田 博之, 佐々木 健吾, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 石田 孝宣, 力山 敏樹, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　SF-1:[P]　2019年4月

    出版者・発行元： (一社)日本外科学会

  50. 多職種介入によるNSTの現状と問題点

    中西 渉, 宮城 重人, 戸子台 和哲, 西村 隆一, 佐々木 健吾, 福岡 健吾, 熊田 博之, 石田 孝宣, 内藤 剛, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　119回　PS-1　2019年4月

    出版者・発行元： (一社)日本外科学会

  51. 当科における12歳未満の小児生体肝移植の成績について

    藤尾 淳, 宮城 重人, 中西 史, 戸子台 和哲, 中西 渉, 西村 隆一, 佐々木 健吾, 福岡 健吾, 熊田 博之, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　PS-6　2019年4月

    出版者・発行元： (一社)日本外科学会

  52. 肝・膵粘液性嚢胞腫瘍における卵巣様間質でのステロイドホルモン合成動態についての免疫組織化学的検討

    熊田 博之, 宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 佐々木 健吾, 福岡 健吾, 内藤 剛, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　119回　PS-1　2019年4月

    出版者・発行元： (一社)日本外科学会

  53. 甲状腺髄様癌が傍神経節腫に腫瘍内転移したMEN2Bの一例

    菖野 佳浩, 戸子台 和哲, 西村 隆一, 中西 渉, 藤尾 淳, 佐々木 健吾, 福岡 健吾, 柿崎 裕太, 宮城 重人, 亀井 尚, 石田 孝宣, 海野 倫明, 山崎 有人, 笹野 公伸

    日本内分泌学会雑誌　95　(1)　497-497　2019年4月

    出版者・発行元： (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  54. 慢性抗体関連型拒絶の病理像を呈しDPにのみDSAを認めた1例

    福岡 健吾, 戸子台 和哲, 宮城 重人, 中西 渉, 西村 隆一, 藤尾 淳, 佐々木 健吾, 柿崎 裕太, 海野 倫明, 亀井 尚

    日本臨床腎移植学会プログラム・抄録集　52回　254-254　2019年2月

    出版者・発行元： (一社)日本臨床腎移植学会

  55. 抗ドナー血液型抗体価4096倍のABO血液型不適合生体肝移植症例の経験 脱感作療法の重要性について

    齋藤 純健, 宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆, 佐々木 健吾, 福岡 健吾, 柿崎 裕太, 後藤 昌史, 亀井 尚, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　206回　84-84　2019年2月

    出版者・発行元： 日本消化器病学会-東北支部

  56. 膵腎同時移植後の血管合併症と対策

    宮城重人, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 佐々木健吾, 福岡健吾, 柿崎裕太, 笹嶋秀憲, 亀井尚, 海野倫明, 後藤昌史, 後藤昌史

    日本膵・膵島移植研究会プログラム・抄録集　46th　2019年

  57. 【PSC(2)】doublecortin domain-containing 2(DCDC2)遺伝子異常を検出したneonatal sclerosing cholangitisの1例

    佐々木 健吾, 福田 晃也, 武田 昌寛, 内田 孟, 平田 義弘, 阪本 靖介, 入江 恵理, 義岡 孝子, 全 陽, 岩間 達, 乾 あやの, 藤澤 知雄, 笠原 群生

    日本小児栄養消化器肝臓学会雑誌　32　(2)　152-152　2018年12月

    出版者・発行元： 日本小児栄養消化器肝臓学会

    ISSN： 1346-9037

  58. 偶発的に発見された低酸素血症から肝肺症候群と診断された一例

    川崎 健太, 西亦 繁雄, 呉 宗憲, 春日 晃子, 三浦 太郎, 堤 範音, 柏木 保代, 笠原 群生, 阪本 靖介, 福田 晃也, 平田 義弘, 佐々木 健吾, 河島 尚志

    日本小児栄養消化器肝臓学会雑誌　32　(2)　156-156　2018年12月

    出版者・発行元： 日本小児栄養消化器肝臓学会

    ISSN： 1346-9037

  59. ミニ腸におけるトランスポーターの発現と代謝機能

    佐々木 健吾, 町田 正和, 川崎 友之, 内田 孟, 阪本 靖介, 梅澤 明弘, 笠原 群生, 阿久津 英憲

    移植　53　(2-3)　229-229　2018年11月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  60. 小児移植後長期経過例の諸問題 小児肝移植後長期経過例の問題点

    笠原 群生, 上遠野 雅美, 久保田 智美, 福田 晃也, 平田 義弘, 佐々木 健吾, 内田 孟, 武田 昌寛, 阪本 靖介

    移植　53　(総会臨時)　285-285　2018年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  61. 小児生体肝移植においてドナー肝の脂肪変性が予後に与える影響

    入江 理恵, 中澤 温子, 武田 昌寛, 佐々木 健吾, 内田 孟, 平田 義弘, 福田 晃也, 阪本 靖介, 義岡 孝子, 笠原 群生

    移植　53　(総会臨時)　377-377　2018年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  62. 先天性心疾患を合併した胆道閉鎖症に対する生体肝移植の治療報告

    武田 昌寛, 佐々木 健吾, 内田 孟, 平田 義弘, 福田 晃也, 阪本 靖介, 笠原 群生

    移植　53　(総会臨時)　402-402　2018年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  63. 腎障害の有無による小児肝移植例の長期腎予後:471例の解析

    佐藤 舞, 石倉 健司, 武田 昌寛, 佐々木 健吾, 内田 孟, 平田 義弘, 福田 晃也, 阪本 靖介, 笠原 群生

    移植　53　(総会臨時)　403-403　2018年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  64. 小児肝移植術後5年以上経発症例の検討

    阪本 靖介, 福田 晃也, 入江 理恵, 内田 孟, 佐々木 健吾, 武田 昌寛, 平田 義弘, 義岡 孝子, 笠原 群生

    移植　53　(総会臨時)　404-404　2018年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  65. 小児肝移植におけるDonor specific anti-HLA antibody(DSA)の意義

    平田 義弘, 阪本 靖介, 武田 昌寛, 佐々木 健吾, 内田 孟, 福田 晃也, 笠原 群生

    移植　53　(総会臨時)　448-448　2018年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  66. 小児肝移植後の胆管狭窄 胆汁排泄シンチグラフィーを目安としたPTBD介入時期の検討

    平田 義弘, 阪本 靖介, 佐々木 健吾, 成本 壮一, 福田 晃也, 笠原 群生

    日本小児外科学会雑誌　54　(3)　737-737　2018年5月

    出版者・発行元： (NPO)日本小児外科学会

    ISSN： 0288-609X

    eISSN： 2187-4247

  67. 小児肝移植手術における門脈再建法とその工夫

    阪本 靖介, 北嶋 俊寛, 佐々木 健吾, 平田 義弘, 成本 壮一, 福田 晃也, 笠原 群生

    日本外科学会定期学術集会抄録集　118回　1241-1241　2018年4月

    出版者・発行元： (一社)日本外科学会

  68. 小児肝移植後の癒着性腸閉塞についての検討

    平田 義弘, 阪本 靖介, 佐々木 健吾, 成本 壮一, 福田 晃也, 笠原 群生

    日本腹部救急医学会雑誌　38　(2)　408-408　2018年2月

    出版者・発行元： (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  69. 門脈体循環シャントに対しAmplatzer Vascular Plugを用いて治療を行った10例の検討

    平田 義弘, 阪本 靖介, 佐々木 健吾, 成本 壮一, 福田 晃也, 宮嵜 治, 野坂 俊介, 笠原 群生

    日本小児科学会雑誌　122　(2)　251-251　2018年2月

    出版者・発行元： (公社)日本小児科学会

    ISSN： 0001-6543

  70. 肝移植を施行した薬剤起因性胆管消失症候群の1例

    本間 貴士, 佐々木 美香, 米沢 俊一, 伊藤 貴伸, 星 雄介, 角田 文彦, 虻川 大樹, 武山 淳二, 佐々木 健吾, 成本 壮一, 福田 晃也, 阪本 靖介, 笠原 群生, 入江 理恵, 義岡 孝子

    日本小児栄養消化器肝臓学会雑誌　31　(2)　100-100　2017年12月

    出版者・発行元： 日本小児栄養消化器肝臓学会

    ISSN： 1346-9037

  71. 当院における側副血行路処理の工夫(Cruise technique、Central approach)とその有効性

    佐々木 健吾, 阪本 靖介, 成本 壮一, 福田 晃也, 笠原 群生

    移植　52　(4-5)　432-432　2017年11月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  72. 2歳以下小児血液型不適合肝移植術後に発症した抗体関連拒絶反応

    成本 壮一, 阪本 靖介, 佐々木 健吾, 内田 孟, 福田 晃也, 笠原 群生

    移植　52　(4-5)　437-438　2017年11月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  73. オルニチントランスカルバミラーゼ欠損症に対する生体肝移植後急速に線維化が進行した1例

    入江 理恵, 中澤 温子, 佐々木 健吾, 内田 孟, 成本 壮一, 福田 晃也, 阪本 靖介, 義岡 孝子, 笠原 群生

    移植　52　(4-5)　468-468　2017年11月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  74. 小児肝移植患者における静注ganciclovirと経口valganciclovirのAUC同等性比較と有効性・安全性に関する検討

    齊藤 順平, 石原 里美, 内田 孟, 佐々木 健吾, 成本 壮一, 阪本 靖介, 福田 晃也, 笠原 群生, 石川 洋一

    移植　52　(4-5)　366-373　2017年11月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  75. LIVING DONOR LIVER TRANSPLANTATION DURING THE FIRST THREE MONTHS OF LIFE: CARVING THE LIVER FOR SMALL BABIES

    Mureo Kasahara, Seisuke Sakamoto, Akinari Fukuda, Kengo Sasaki, Soichi Narumoto

    TRANSPLANT INTERNATIONAL　30　158-158　2017年9月

    ISSN： 0934-0874

    eISSN： 1432-2277

  76. 消化器・肝臓領域における再生医療の可能性 多能性幹細胞の自己組織化によるミニ小腸作製とその応用

    阿久津 英憲, 内田 孟, 佐々木 健吾, 阪本 靖介, 梅澤 明弘, 笠原 群生

    日本小児栄養消化器肝臓学会雑誌　31　(Suppl.)　86-86　2017年9月

    出版者・発行元： 日本小児栄養消化器肝臓学会

    ISSN： 1346-9037

  77. ヒト多能性幹細胞を用いたミニ腸の作製

    内田 孟, 町田 正和, 川崎 友之, 佐々木 健吾, 阪本 靖介, 梅澤 明弘, 笠原 群生, 阿久津 英憲

    移植　52　(2-3)　287-287　2017年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  78. ヒト多能性幹細胞由来腸管オルガノイドの代謝機能評価

    佐々木 健吾, 町田 正和, 川崎 友之, 内田 孟, 阪本 靖介, 梅澤 明弘, 笠原 群生, 阿久津 英憲

    移植　52　(2-3)　288-288　2017年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  79. 粉砕して調製した院内製剤シロリムス希釈散の製剤学的安定性および臨床的有効性と安全性に関する検討

    齊藤 順平, 石原 里美, 詫間 梨恵, 成本 壮一, 佐々木 健吾, 阪本 靖介, 福田 晃也, 笠原 群生, 石川 洋一

    医学と薬学　74　(9)　1063-1069　2017年8月

    出版者・発行元： (株)自然科学社

    ISSN： 0389-3898

  80. 小児肝移植後グラフト不全のリスク因子となる病理組織学的変化の検討

    入江 理恵, 中澤 温子, 佐々木 健吾, 成本 壮一, 福田 晃也, 阪本 靖介, 義岡 孝子, 笠原 群生

    移植　52　(総会臨時)　325-325　2017年8月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  81. 当院における減量外側区域グラフト使用症例の検討

    北嶋 俊寛, 阪本 靖介, 佐々木 健吾, 成本 壮一, 福田 晃也, 笠原 群生

    移植　52　(総会臨時)　377-377　2017年8月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  82. 当院における肝芽腫に対する外科的治療戦略

    阪本 靖介, 内田 孟, 佐々木 健吾, 北嶋 俊寛, 成本 壮一, 福田 晃也, 笠原 群生

    移植　52　(総会臨時)　380-380　2017年8月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  83. 当院におけるマージナルグラフト使用症例の検討

    成本 壮一, 阪本 靖介, 佐々木 健吾, 福田 晃也, 笠原 群生

    移植　52　(総会臨時)　519-519　2017年8月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  84. 葛西手術後胆道閉鎖症に対する生体肝移植の適応・成績と移植後予後不良因子の検討

    北嶋 俊寛, 阪本 靖介, 佐々木 健吾, 内田 孟, 重田 孝信, 成本 壮一, 福田 晃也, 笠原 群生

    日本消化器外科学会総会　72回　PN13-3　2017年7月

    出版者・発行元： (一社)日本消化器外科学会

  85. 内臓逆位を伴った胆道閉鎖症葛西手術後症例に対する生体肝移植術

    阪本 靖介, 北嶋 俊寛, 内田 孟, 重田 孝信, 佐々木 健吾, 成本 壮一, 福田 晃也, 笠原 群生

    日本小児外科学会雑誌　53　(2)　342-342　2017年4月

    出版者・発行元： (NPO)日本小児外科学会

    ISSN： 0288-609X

    eISSN： 2187-4247

  86. 当院における葛西手術後胆道閉鎖症に対する生体肝移植の適応と成績

    北嶋 俊寛, 阪本 靖介, 佐々木 健吾, 内田 孟, 重田 孝信, 成本 壮一, 福田 晃也, 笠原 群生

    日本小児外科学会雑誌　53　(2)　342-342　2017年4月

    出版者・発行元： (NPO)日本小児外科学会

    ISSN： 0288-609X

    eISSN： 2187-4247

  87. γGTP値が正常である小児胆汁鬱滞性肝疾患症例に対する肝移植の経験

    重田 孝信, 佐々木 健吾, 内田 孟, 成本 壮一, 福田 晃也, 阪本 靖介, 伊藤 玲子, 笠原 群生

    日本小児栄養消化器肝臓学会雑誌　30　(2)　93-93　2016年12月

    出版者・発行元： 日本小児栄養消化器肝臓学会

    ISSN： 1346-9037

  88. 肝外門脈閉塞症に脾腎シャント造設術を施行した1例

    金澤 寛之, 福田 晃也, 佐々木 健吾, 内田 孟, 重田 孝信, 平田 義弘, 宮嵜 治, 野坂 俊介, 阪本 靖介, 笠原 群生

    日本小児外科学会雑誌　52　(6)　1270-1270　2016年10月

    出版者・発行元： (NPO)日本小児外科学会

    ISSN： 0288-609X

    eISSN： 2187-4247

  89. 当院における胆道閉鎖症に対する小児生体肝移植後、成長に関与する因子の検討

    重田 孝信, 阪本 靖介, 佐々木 健吾, 内田 孟, 成本 壮一, 福田 晃也, 笠原 群生

    移植　51　(総会臨時)　240-240　2016年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  90. 常染色体劣性多発性嚢胞腎の長期予後 肝移植と腎移植の戦略

    佐藤 舞, 石倉 健司, 小椋 雅夫, 亀井 宏一, 佐々木 健吾, 内田 孟, 重田 孝信, 成本 壮一, 福田 晃也, 阪本 靖介, 笠原 群生

    移植　51　(総会臨時)　249-249　2016年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  91. 当院での造血幹細胞移植後の慢性肝GVHDに対する生体肝移植経験

    内田 孟, 阪本 靖介, 佐々木 健吾, 成本 荘一, 重田 孝信, 福田 晃也, 笠原 群生

    移植　51　(総会臨時)　253-253　2016年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  92. 当院における小児肝移植術後中枢神経合併症の検討

    成本 壮一, 内田 孟, 阪本 靖介, 佐々木 健吾, 重田 孝信, 福田 晃也, 笠原 群生

    移植　51　(総会臨時)　263-263　2016年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  93. 小児生体肝移植後の移植後リンパ増殖性疾患の予防と治療に関する検討

    福田 晃也, 今留 謙一, 佐々木 健吾, 内田 孟, 成本 壮一, 重田 孝信, 入江 理恵, 義岡 孝子, 阪本 靖介, 笠原 群生

    移植　51　(総会臨時)　267-267　2016年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  94. ヒト多能性幹細胞を用いた全機能型腸管オルガノイドの作製

    内田 孟, 阿久津 英憲, 佐々木 健吾, 阪本 靖介, 梅澤 明弘, 笠原 群生

    移植　51　(2-3)　312-312　2016年8月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  95. Hyperammonemia in the Ornithine Transcarbamylase Deficiency Recipients Underwent Living Donor Liver Transplantation from Heterozygous Carrier Donor

    Tri Hening Rahayatri, Hajime Uchida, Kengo Sasaki, Takanobu Shigeta, Yoshihiro Hirata, Hiroyuki Kanazawa, Vidyadhar Mali, Akinari Fukuda, Mureo Kasahara

    TRANSPLANTATION　100　S231-S231　2016年5月

    ISSN： 0041-1337

    eISSN： 1534-6080

  96. 小児肝移植ドナープール拡大のための脳死分割肝移植・メープルシロップ尿症患児からの生体ドミノ肝移植の現状

    福田 晃也, 佐々木 健吾, 内田 孟, 重田 孝信, 金澤 寛之, 成本 壮一, 鈴木 達也, 水田 耕一, 堀川 玲子, 笠原 群生

    日本外科学会定期学術集会抄録集　116回　OP-4　2016年4月

    出版者・発行元： (一社)日本外科学会

  97. 小児脳死分割肝移植の治療成績

    福田 晃也, 松波 昌寿, 佐々木 健吾, 平田 義弘, 内田 孟, 重田 孝信, 金澤 寛之, 中澤 温子, 笠原 群生

    日本小児栄養消化器肝臓学会雑誌　29　(2)　134-134　2015年12月

    出版者・発行元： 日本小児栄養消化器肝臓学会

    ISSN： 1346-9037

  98. TWO CASES OF HEPATOCYTE TRANSPLANTATION FOR UREA CYCLE DISORDERS BY USING HEPATOCYTES ISOLATED FROM LIVING DONOR REDUCED GRAFTS.

    Takanobu Shigeta, Shin Enosawa, Yoshihiro Hirata, Kengo Sasaki, Hajime Uchida, Hiroyuki Kanazawa, Akinari Fukuda, Kazuaki Nakamura, Reiko Horikawa, Shunsuke Nosaka, Mureo Kasahara

    TRANSPLANTATION　99　(11)　S219-S219　2015年11月

    ISSN： 0041-1337

    eISSN： 1534-6080

  99. SINGLE CENTER EXPERIENCE OF ABO-INCOMPATIBLE PEDIATRIC LIVING DONOR LIVER TRANSPLANTATION

    Kengo Sasaki, Akinari Fukuda, Masatoshi Matsunami, Hajime Uchida, Takanobu Shigeta, Hiroyuki Kanazawa, Atsuko Nakazawa, Mureo Kasahara

    TRANSPLANT INTERNATIONAL　28　788-788　2015年11月

    ISSN： 0934-0874

    eISSN： 1432-2277

  100. Two cases of hepatocyte transplantation for urea cycle disorders by using hepatocytes isolated from living donor reduced grafts

    Takanobu Shigeta, Shin Enosawa, Yoshihiro Hirata, Kengo Sasaki, Hajime Uchida, Hiroyuki Kanazawa, Akinari Fukuda, Kazuaki Nakamura, Reiko Horikawa, Shunsuke Nosaka, Mureo Kasahara

    XENOTRANSPLANTATION　22　S131-S132　2015年11月

    ISSN： 0908-665X

    eISSN： 1399-3089

  101. THE EXCELLENT OUTCOMES IN LIVING DONOR LIVER TRANSPLANTATION FOR INFANTS WITH ACUTE LIVER FAILURE: A SINGLE CENTER EXPERIENCE

    Hajime Uchida, Akinari Fukuda, Kengo Sasaki, Masatoshi Matusnami, Takanobu Shigeta, Hiroyuki Kanazawa, Atsuko Nakazawa, Mureo Kasahara

    TRANSPLANT INTERNATIONAL　28　416-416　2015年11月

    ISSN： 0934-0874

    eISSN： 1432-2277

  102. ブタ小腸移植モデルにおける、水素含有保存液を用いた小腸グラフト保存の効果

    重田 孝信, 阪本 靖介, 黒川 亮介, 内田 孟, 佐々木 健吾, 中澤 温子, 梨井 康, 笠原 群生

    移植　50　(4-5)　444-444　2015年10月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  103. 小児分割肝移植の自施設における治療成績の検討

    福田 晃也, 松波 昌寿, 平田 義弘, 佐々木 健吾, 内田 孟, 重田 孝信, 金澤 寛之, 中澤 温子, 笠原 群生

    移植　50　(4-5)　490-490　2015年10月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  104. 門脈再建でpullout techniqueを適用した小児肝移植症例の検討

    金澤 寛之, 松波 昌寿, 佐々木 健吾, 内田 孟, 重田 孝信, 福田 晃也, 笠原 群生

    移植　50　(4-5)　510-510　2015年10月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  105. 胆道閉鎖症に対する肝移植における門脈間置グラフトの必要性予後因子の検討

    内田 孟, 福田 晃也, 佐々木 健吾, 松波 昌寿, 重田 孝信, 金澤 寛之, 笠原 群生

    移植　50　(4-5)　511-512　2015年10月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  106. ミトコンドリア ミトコンドリア呼吸鎖異常症の7例

    伊藤 玲子, 佐々木 健吾, 福田 晃也, 工藤 豊一郎, 松浪 昌寿, 内田 孟, 重田 孝信, 金澤 寛之, 中澤 温子, 堀川 玲子, 松井 陽, 村山 圭, 笠原 群生

    日本小児栄養消化器肝臓学会雑誌　29　(Suppl.)　75-75　2015年9月

    出版者・発行元： 日本小児栄養消化器肝臓学会

    ISSN： 1346-9037

  107. ドミノ肝移植の現状と今後の展望 メープルシロップ尿症患者からの小児生体ドミノ肝移植4例の経験

    福田 晃也, 佐々木 健吾, 内田 孟, 重田 孝信, 平田 義弘, 金澤 寛之, 堀川 玲子, 鈴木 達也, 水田 耕一, 笠原 群生

    移植　50　(総会臨時)　266-266　2015年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  108. 小児肝移植例の長期腎機能予後 314例の解析

    佐藤 舞, 石倉 健司, 松波 昌寿, 佐々木 健吾, 内田 孟, 重田 孝信, 金澤 寛之, 福田 晃也, 笠原 群生, 金子 徹治

    移植　50　(総会臨時)　313-313　2015年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  109. 当院におけるABO血液型不適合生体肝移植の治療成績

    佐々木 健吾, 福田 晃也, 内田 孟, 重田 孝信, 平田 義弘, 金澤 寛之, 笠原 群生

    移植　50　(総会臨時)　468-468　2015年9月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  110. 当院における小児ABO血液型不適合生体肝移植の治療成績

    佐々木 健吾, 松波 昌寿, 内田 孟, 重田 孝信, 金澤 寛之, 福田 晃也, 中澤 温子, 阪本 靖介, 笠原 群生

    移植　50　(2-3)　251-251　2015年8月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  111. 小児肝移植後のグラフト機能不全症例に対する再肝移植

    松波 昌寿, 福田 晃也, 佐々木 健吾, 内田 孟, 重田 孝信, 中澤 温子, 阪本 靖介, 笠原 群生

    移植　50　(2-3)　256-256　2015年8月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  112. 小児肝移植後におけるシロリムスの使用経験

    重田 孝信, 福田 晃也, 金澤 寛之, 内田 孟, 佐々木 健吾, 松波 昌寿, 阪本 靖介, 笠原 群生

    移植　50　(2-3)　266-266　2015年8月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  113. 小児肝細胞癌合併肝硬変症例に対するtemporaryportocavalshuntを用いた全肝摘出

    金澤 寛之, 福田 晃也, 佐々木 健吾, 重田 孝信, 内田 孟, 松波 昌寿, 浜野 郁美, 阪本 靖介, 笠原 群生

    移植　50　(2-3)　268-269　2015年8月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  114. S2モノセグメントグラフト乳児生体肝移植症例の検討

    内田 孟, 福田 晃也, 佐々木 健吾, 松波 昌寿, 金澤 寛之, 阪本 靖介, 野坂 俊介, 笠原 群生

    移植　50　(2-3)　281-281　2015年8月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  115. 細胞移植 肝細胞移植の展望 新生児期発症の尿素サイクル異常への移植経験から

    重田 孝信, 絵野沢 伸, 松波 昌寿, 佐々木 健吾, 内田 孟, 金澤 寛之, 福田 晃也, 堀川 玲子, 野坂 俊介, 笠原 群生

    Organ Biology　22　(2)　69-73　2015年7月

    出版者・発行元： (一社)日本臓器保存生物医学会

    ISSN： 1340-5152

    eISSN： 2188-0204

  116. Amplatzer Vascular Plugによる塞栓術が有効であった先天性肝外門脈体循環短絡2型の1例

    野坂 俊介, 宮嵜 治, 田島 廣之, 金澤 寛之, 佐々木 健吾, 福田 晃也, 小野 博, 賀藤 均, 笠原 群生

    IVR: Interventional Radiology　30　(2)　176-177　2015年6月

    出版者・発行元： (一社)日本インターベンショナルラジオロジー学会

    ISSN： 1340-4520

    eISSN： 2185-6451

  117. 切除不能肝芽腫に対する生体肝移植術における術中血行性播種低減のための工夫

    松波 昌寿, 佐々木 健吾, 内田 孟, 重田 孝信, 金澤 寛之, 福田 晃也, 中澤 温子, 笠原 群生

    日本小児外科学会雑誌　51　(3)　480-480　2015年5月

    出版者・発行元： (NPO)日本小児外科学会

    ISSN： 0288-609X

    eISSN： 2187-4247

  118. 困難例に対する肝移植手術の工夫と限界 基礎研究・移植再生 小児間における生体ドミノ肝移植 手術における問題点と工夫

    松波 昌寿, 佐々木 健吾, 内田 孟, 重田 孝信, 金澤 寛之, 福田 晃也, 水田 耕一, 笠原 群生

    日本外科学会定期学術集会抄録集　115回　PD-6　2015年4月

    出版者・発行元： (一社)日本外科学会

  119. 改正臓器移植法施行から5年 脳死移植は普及したのか? 基礎研究・移植再生 小児脳死肝移植は普及したのか?

    笠原 群生, 福田 晃也, 金澤 寛之, 松波 昌寿, 重田 孝信, 佐々木 健吾, 内田 孟, 阪本 靖介

    日本外科学会定期学術集会抄録集　115回　SY-2　2015年4月

    出版者・発行元： (一社)日本外科学会

  120. 小児 切除不能肝芽腫に対する小児肝移植症例の検討

    金澤 寛之, 松波 昌寿, 佐々木 健吾, 内田 孟, 重田 孝信, 福田 晃也, 笠原 群生

    日本外科学会定期学術集会抄録集　115回　OP-2　2015年4月

    出版者・発行元： (一社)日本外科学会

  121. 知っておきたい稀な肝胆膵疾患 有機酸代謝異常症(メチルマロン酸血症、プロピオン酸血症)

    佐々木 健吾, 笠原 群生

    肝・胆・膵　70　(1)　159-168　2015年1月

    出版者・発行元： (株)アークメディア

    ISSN： 0389-4991

  122. 進行性家族性肝内胆汁うっ滞症(PFIC)2型4例に対する生体肝移植の経験

    松波 昌寿, 佐々木 健吾, 内田 孟, 重田 孝信, 金澤 寛之, 福田 晃也, 中澤 温子, 笠原 群生

    日本小児栄養消化器肝臓学会雑誌　28　(2)　140-140　2014年12月

    出版者・発行元： 日本小児栄養消化器肝臓学会

    ISSN： 1346-9037

  123. 細胞移植 肝細胞移植の展望 尿素回路異常新生児への移植例から

    重田 孝信, 絵野沢 伸, 松波 昌寿, 佐々木 健吾, 内田 孟, 金澤 寛之, 福田 晃也, 堀川 玲子, 野坂 俊介, 笠原 群生

    Organ Biology　21　(3)　54-54　2014年10月

    出版者・発行元： (一社)日本臓器保存生物医学会

    ISSN： 1340-5152

    eISSN： 2188-0204

  124. 劇症肝炎に対する肝移植 小児劇症肝不全に対する肝移植治療成績の検討

    内田 孟, 福田 晃也, 佐々木 健吾, 松波 昌寿, 重田 孝信, 金澤 寛之, 中澤 温子, 笠原 群生

    日本移植学会総会プログラム抄録集　50回　277-277　2014年8月

    出版者・発行元： (一社)日本移植学会

  125. 乳幼児胆道閉鎖症肝移植患者におけるWaterlow分類の有用性の検討

    重田 孝信, 福田 晃也, 金澤 寛之, 内田 孟, 佐々木 健吾, 松波 昌寿, 笠原 群生

    日本移植学会総会プログラム抄録集　50回　288-288　2014年8月

    出版者・発行元： (一社)日本移植学会

  126. 小児脳死肝移植数増加のための方策

    福田 晃也, 松波 昌寿, 佐々木 健吾, 内田 孟, 重田 孝信, 中澤 温子, 笠原 群生

    日本移植学会総会プログラム抄録集　50回　291-291　2014年8月

    出版者・発行元： (一社)日本移植学会

  127. ミトコンドリア呼吸鎖異常症を原因とする劇症肝不全に対し生体肝移植を行った2例

    佐々木 健吾, 松波 昌寿, 内田 孟, 重田 孝信, 金澤 寛之, 福田 晃也, 中澤 温子, 堀川 玲子, 村山 圭, 笠原 群生

    日本移植学会総会プログラム抄録集　50回　396-396　2014年8月

    出版者・発行元： (一社)日本移植学会

  128. 尿素サイクル異常症に対する肝細胞移植および肝移植の検討

    松波 昌寿, 佐々木 健吾, 内田 孟, 重田 孝信, 金澤 寛之, 福田 晃也, 中澤 温子, 堀川 玲子, 笠原 群生

    日本移植学会総会プログラム抄録集　50回　404-404　2014年8月

    出版者・発行元： (一社)日本移植学会

  129. The Outcomes of Living Donor Liver Transplantation Receiving Reduced Left Lateral Segmental Grafts

    S. Sakamoto, H. Kanazawa, H. Uchida, T. Shigeta, K. Sasaki, A. Fukuda, M. Kasahara

    TRANSPLANTATION　98　171-172　2014年7月

    ISSN： 0041-1337

    eISSN： 1534-6080

  130. The Outcomes of Living Donor Liver Transplantation Receiving Reduced Left Lateral Segmental Grafts.

    S. Sakamoto, H. Kanazawa, H. Uchida, T. Shigeta, K. Sasaki, A. Fukuda, M. Kasahara

    AMERICAN JOURNAL OF TRANSPLANTATION　14　171-172　2014年6月

    ISSN： 1600-6135

    eISSN： 1600-6143

  131. Acoustic Radiation Force Impulse as Auxiliary Diagnostic Method for the Indication of Liver Transplantation in Patients with Biliary Atresia.

    Hajime Uchida, Seisuke Sakamoto, Kengo Sasaki, Takanobu Shigeta, Mikiko Miyasaka, Shunsuke Nosaka, Mureo Kasahara

    LIVER TRANSPLANTATION　20　S283-S283　2014年6月

    ISSN： 1527-6465

    eISSN： 1527-6473

  132. 乳児急性肝不全における肝移植後ステロイド抵抗性拒絶反応に対するBasiliximabの使用経験

    重田 孝信, 阪本 靖介, 内田 孟, 佐々木 健吾, 浜野 郁美, 金澤 寛之, 福田 晃也, 中澤 温子, 笠原 群生

    移植　49　(1)　72-72　2014年5月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  133. 左葉系グラフトを用いた小児生体肝移植での術後胆管狭窄についての検討

    金澤 寛之, 阪本 靖介, 福田 晃也, 濱野 郁美, 内田 孟, 佐々木 健吾, 重田 孝信, 田中 秀明, 中澤 温子, 笠原 群生

    移植　49　(1)　113-113　2014年5月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  134. 肝細胞移植におけるcell source 超減量外側区域グラフト採取時の余剰肝を用いた細胞分離

    重田 孝信, 絵野沢 伸, 内田 孟, 佐々木 健吾, 浜野 郁美, 金澤 寛之, 福田 晃也, 阪本 靖介, 笠原 群生

    移植　49　(1)　123-123　2014年5月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  135. 6歳未満の小児ドナーからの全肝脳死移植の一例

    浜野 郁美, 阪本 靖介, 佐々木 健吾, 内田 孟, 重田 孝信, 金澤 寛之, 福田 晃也, 笠原 群生

    日本小児栄養消化器肝臓学会雑誌　28　(1)　24-24　2014年4月

    出版者・発行元： 日本小児栄養消化器肝臓学会

    ISSN： 1346-9037

  136. 2度の臓器搬送を要し冷阻血時間が長時間となった脳死肝移植の一例

    佐々木 健吾, 阪本 靖介, 内田 孟, 濱野 郁美, 重田 孝信, 金澤 寛之, 福田 晃也, 小林 めぐみ, 高原 武志, 新田 浩之, 若林 剛, 笠原 群生

    日本小児栄養消化器肝臓学会雑誌　28　(1)　25-25　2014年4月

    出版者・発行元： 日本小児栄養消化器肝臓学会

    ISSN： 1346-9037

  137. 先天性門脈体循環短絡症に対する新分類の提唱

    金澤 寛之, 阪本 靖介, 福田 晃也, 濱野 郁美, 佐々木 健吾, 内田 孟, 重田 孝信, 宮嵜 治, 野坂 俊介, 中澤 温子, 笠原 群生

    日本小児外科学会雑誌　50　(3)　609-609　2014年4月

    出版者・発行元： (NPO)日本小児外科学会

    ISSN： 0288-609X

    eISSN： 2187-4247

  138. PS-002-5 小児生体肝移植後Epstein-Barr virus感染に対するアシクロビル予防投与の必要性に関する検討(PS-002 肝 移植-2,ポスターセッション,第114回日本外科学会定期学術集会)

    福田 晃也, 阪本 靖介, 金澤 寛之, 重田 孝信, 濱野 郁美, 内田 孟, 佐々木 健吾, 今留 謙一, 中澤 温子, 笠原 群生

    日本外科学会雑誌　115　(2)　579-579　2014年3月5日

    出版者・発行元： 一般社団法人日本外科学会

    ISSN： 1880-1129

  139. SY-7-3 小児肝移植での過大グラフトによるサイズミスマッチ克服への工夫(SY-7 シンポジウム(7)肝移植におけるイノベーション,第114回日本外科学会定期学術集会)

    金澤 寛之, 阪本 靖介, 福田 晃也, 濱野 郁美, 佐々木 健吾, 重田 孝信, 内田 孟, 笠原 群生

    日本外科学会雑誌　115　(2)　135-135　2014年3月5日

    出版者・発行元： 一般社団法人日本外科学会

    ISSN： 1880-1129

  140. 肝移植におけるイノベーション 小児肝移植での過大グラフトによるサイズミスマッチ克服への工夫

    金澤 寛之, 阪本 靖介, 福田 晃也, 濱野 郁美, 佐々木 健吾, 重田 孝信, 内田 孟, 笠原 群生

    日本外科学会雑誌　115　(臨増2)　135-135　2014年3月

    出版者・発行元： (一社)日本外科学会

    ISSN： 0301-4894

  141. 小児生体肝移植後Epstein-Barr virus感染に対するアシクロビル予防投与の必要性に関する検討

    福田 晃也, 阪本 靖介, 金澤 寛之, 重田 孝信, 濱野 郁美, 内田 孟, 佐々木 健吾, 今留 謙一, 中澤 温子, 笠原 群生

    日本外科学会雑誌　115　(臨増2)　579-579　2014年3月

    出版者・発行元： (一社)日本外科学会

    ISSN： 0301-4894

  142. 6歳未満小児脳死ドナーからの全肝移植の経験

    浜野 郁美, 阪本 靖介, 福田 晃也, 内田 孟, 佐々木 健吾, 重田 孝信, 金澤 寛之, 中澤 温子, 笠原 群生, 小倉 靖弘, 上本 伸二

    日本外科学会雑誌　114　(6)　340-344　2013年11月

    出版者・発行元： (一社)日本外科学会

    ISSN： 0301-4894

  143. 移植後ウイルス感染症への対策 小児肝移植後EBウイルス感染症への対策

    福田 晃也, 今留 謙一, 阪本 靖介, 佐々木 健吾, 内田 孟, 濱野 郁美, 重田 孝信, 中澤 温子, 笠原 群生

    移植　48　(総会臨時)　213-213　2013年8月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  144. ABO不適合に対する肝移植の現状 短期成績/長期成績 小児ABO血液型不適合に対する生体肝移植の現状

    福田 晃也, 阪本 靖介, 佐々木 健吾, 内田 孟, 浜野 郁美, 重田 孝信, 金澤 寛之, 中澤 温子, 笠原 群生

    移植　48　(総会臨時)　236-236　2013年8月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  145. 原発性高蓚酸尿症1型に対し肝移植を施行した4例

    佐々木 健吾, 阪本 靖介, 内田 孟, 濱野 郁美, 金澤 寛之, 福田 晃也, 高山 達也, 笠原 群生

    移植　48　(総会臨時)　301-301　2013年8月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  146. 乳児胆道閉鎖症に対する生体肝移植における門脈再建の工夫

    重田 孝信, 阪本 靖介, 佐々木 健吾, 内田 孟, 浜野 郁美, 金澤 寛之, 福田 晃也, 笠原 群生

    移植　48　(総会臨時)　303-303　2013年8月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  147. 生体肝移植術を施行した巨大肝静脈血管奇形の一例

    浜野 郁美, 阪本 靖介, 佐々木 健吾, 内田 孟, 重田 孝信, 金澤 寛之, 福田 晃也, 中澤 温子, 笠原 群生

    移植　48　(総会臨時)　324-324　2013年8月

    出版者・発行元： (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  148. 肝移植のためのチーム作り 小児肝移植実施施設の現状と課題

    笠原 群生, 内田 孟, 濱野 郁美, 佐々木 健吾, 金沢 寛之, 福田 晃也, 阪本 靖介

    日本外科系連合学会誌　38　(3)　617-617　2013年5月

    出版者・発行元： 日本外科系連合学会

    ISSN： 0385-7883

    eISSN： 1882-9112

︎全件表示 ︎最初の5件までを表示

書籍等出版物 1

  1. 臓器移植抗体陽性診療ガイドライン

    日本移植学会臓器移植抗体陽性診療ガイドライン策定委員会

    メディカルレビュー社　2018年10月

    ISBN: 9784779221484

講演・口頭発表等 30

  1. 胆道閉鎖症患者における移植機会喪失の可能性とその回避方法

    佐々木健吾, 西牧宏泰, 宮崎勇希, 松村宗幸, 宮澤恒持, 柏舘俊明, 藤尾淳, 戸子台和哲, 宮城重人, 海野倫明, 亀井尚

    第122回日本外科学会定期学術集会　2022年4月16日

  2. 当院における肝移植レシピエント、生体ドナー候補者の後方視的検討

    佐々木健吾, 金井哲史, 齋藤純健, 松村宗幸, 宮澤恒持, 柏館俊明, 藤尾淳, 戸子台和哲, 宮城重人, 海野倫明, 亀井尚

    第57回日本移植学会総会　2021年9月19日

  3. 当院における小児肝移植の現状と今後の課題

    佐々木健吾, 宮城重人, 戸子台和哲, 中西渉, 藤尾淳, 柏舘俊明, 亀井尚, 海野倫明

    第121回日本外科学会定期学術集会　2021年4月8日

  4. 東北大学病院における小児肝移植の現状と今後の課題

    佐々木健吾, 太田嶺人, 菖野佳浩, 藤尾淳, 柏舘俊明, 中西渉, 戸子台和哲, 宮城重人, 亀井尚, 海野倫明

    第38回日本肝移植学会学術集会　2020年12月25日

  5. 肝移植後胆管空腸吻合部狭窄に対し，ブロッケンブロー針を用いて胆管空腸の瘻孔化に成功した一例

    佐々木健吾, 宮城重人, 笹嶋秀憲, 宮崎勇希, 藤尾淳, 西村隆一, 中西渉, 戸子台和哲, 大田英揮, 高瀬圭, 亀井尚, 海野倫明

    第55回日本移植学会総会　2019年10月10日

  6. 高度心機能低下を有するWilson病患者に対し，肝移植後，大動脈内バルーンパンピングを使用し救命した一例

    佐々木健吾, 宮城重人, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 福岡健吾, 内藤剛, 海野倫明, 亀井尚

    第74回日本消化器外科学会総会　2019年7月18日

  7. 東北大学病院における小児肝移植の現状と今後の課題

    佐々木健吾, 宮城重人, 笹嶋秀憲, 柿崎裕太, 福岡健吾, 藤尾淳, 西村隆一, 中西渉, 戸子台和哲, 亀井尚, 海野倫明

    第30回東北小児肝胆膵消化管研究会　2019年3月16日

  8. doublecortin domain-containing 2 (DCDC2)遺伝子異常を検出したneonatal sclerosing cholantitisの1例

    佐々木健吾, 福田晃也, 武田昌寛, 内田孟, 平田義弘, 阪本靖介, 入江恵理, 義岡孝子, 全陽, 岩間達, 乾あやの, 藤澤知雄, 笠原群生

    第35回日本小児肝臓研究会　2018年7月14日

  9. A novel technique to get sufficient portal vein flow in the pediatric living donor liver transplantation

    佐々木健吾, 阪本靖介, 武田昌寛, 平田義弘, 内田孟, 福田晃也, 笠原群生

    第30回日本肝胆膵外科学会学術集会　2018年6月8日

  10. 小児肝移植後の抗体関連拒絶反応の検討

    佐々木健吾, 武田昌寛, 平田義弘, 内田孟, 福田晃也, 阪本靖介, 入江理恵, 義岡孝子, 笠原群生

    第36回日本肝移植研究会　2018年5月25日

  11. 下大静脈浸潤を伴う再発肝芽腫に対する 下大静脈合併切除手術の有効性

    佐々木健吾

    第72回手術手技研究会　2018年5月12日

  12. ミニ腸におけるトランスポーターの発現と代謝機能

    佐々木健吾, 町田正和, 川崎友之, 内田孟, 阪本靖介, 梅澤明弘, 笠原群生, 阿久津英憲

    第30回日本小腸移植研究会　2018年2月10日

  13. 嚢胞性腎疾患のない嚢胞性肝疾患に対する肝移植後に進行性の高度腎障害を来した1例

    佐々木健吾

    第9回小児肝臓・肝移植セミナー　2017年9月30日

  14. 当院における側副血行路処理の工夫(Cruise technique, Central approach)とその有効性

    佐々木健吾, 阪本靖介, 成本壮一, 福田晃也, 笠原群生

    第35回日本肝移植研究会　2017年6月1日

  15. ヒト多能性幹細胞由来腸管オルガノイドの代謝機能評価

    佐々木健吾, 町田正和, 川崎友之, 内田孟, 阪本靖介, 梅澤明弘, 笠原群生, 阿久津英憲

    第29回日本小腸移植研究会　2017年3月4日

  16. Single center experience of liver transplantation for mitochondrial respiratory chain disorder

    Kengo Sasaki, Seisuke Sakamoto, Hajime Uchida, Soichi Narimoto, Takanobu Shigeta, Akinari Fukuda, Kei Murayama, Mureo Kasahara

    Asian Transplantation Week 2016　2016年10月29日

  17. 過蓚酸尿症・先天性肝線維症に対する肝移植・腎移植

    佐々木健吾

    第8回小児肝臓・肝移植セミナー　2016年9月10日

  18. 当院におけるミトコンドリア呼吸鎖異常症に対する肝移植

    佐々木健吾

    第34回日本肝移植研究会　2016年7月7日

  19. Successful Living Donor Domino Liver Transplantation for Biliary Artresia from a Maple Syrup Urine Disease Patient

    Kengo Sasaki, Akinari Fukuda, Hajime Uchida, Soichi Narimoto, Seisuke Sakamoto, Mureo Kasahara

    22nd Annual International Congress of the International Liver Transplant Society　2016年5月6日

  20. Successful living domino liver transplantation using liver from a maple syrup urine disease patient

    Kengo Sasaki, Akinari Fukuda, Hajime Uchida, Yoshihiro Hirata, Takanobu Shigeta, Hiroyuki Kanazawa, Seisuke Sakamoto, Mureo Kasahara

    the 25th Asian Pacific Association for the Study of the Liver　2016年2月23日

  21. 当院におけるABO血液型不適合生体肝移植の治療成績

    佐々木健吾, 福田晃也, 内田孟, 重田孝信, 平田義弘, 金澤寛之, 笠原群生

    第51回日本移植学会総会　2015年10月3日

  22. Single center experience of ABO-incompatible pediatric living donor liver transplantation

    Kengo Sasaki, Akinari Fukuda, Masatoshi Matsunami, Hajime Uchida, Takanobu Shigeta, Hiroyuki Kanazawa, Atsuko Nakazawa, Mureo Kasahara

    the European Society for Organ Transplantation Congress 2015　2015年9月13日

  23. 有機酸代謝異常症（メチルマロン酸血症・プロピオン酸血症）に対する肝移植

    佐々木健吾, 福田晃也, 松波昌寿, 内田孟, 重田隆信, 金澤寛之, 中澤温子, 堀川玲子, 笠原群生

    第33回日本肝移植研究会　2015年5月28日

  24. ミトコンドリア呼吸鎖異常症を原因とする劇症肝不全に対し生体肝移植を行った 2 例

    佐々木健吾, 福田晃也, 松浪昌寿, 内田孟, 重田孝信, 金澤寛之, 中澤温子, 堀川玲子, 笠原群生

    第47回武蔵野小児肝臓病懇話会　2014年12月2日

  25. ミトコンドリア呼吸鎖異常症を原因とする劇症肝不全に対し生体肝移植を行った2例

    佐々木健吾, 松波昌寿, 内田孟, 重田孝信, 金澤寛之, 福田晃也, 中澤温子, 堀川玲子, 村山圭, 笠原群生

    第50回日本移植学会　2014年9月11日

  26. 当院における小児ABO血液型不適合生体肝移植の治療成績

    佐々木健吾, 松波昌寿, 内田孟, 重田孝信, 金澤寛之, 福田晃也, 中澤温子, 阪本靖介, 笠原群生

    第32回日本肝移植研究会　2014年7月3日

  27. 原発性高蓚酸尿症1型に対し生体肝移植を施行した5例

    佐々木健吾, 濱野郁美, 内田孟, 重田孝信, 金澤寛之, 福田晃也, 阪本靖介, 中澤温子, 笠原群生, 松井陽

    第46回武蔵野小児肝臓病懇話会　2013年12月3日

  28. Living donor liver transplantation for primary hyperoxaluria type 1

    Kengo Sasaki, Seisuke Sakamoto, Hajime Uchida, Ikumi Hamano, Takanobu Shigeta, Hiroyuki Kanazawa, Akinari Fukuda, Tatsuya Takayama, Masao Nagata, Mureo Kasahara, Akira Mastui

    13th Asian Pan-Pacific Society for Pediatric Gastroenterology, Hepatology and Nutrition　2013年11月1日

  29. 原発性高蓚酸尿症1型に対し肝移植を施行した4例

    佐々木健吾, 阪本靖介, 福田晃也, 金澤寛之, 濱野郁美, 内田孟, 笠原群生

    第49回日本移植学会総会　2013年9月6日

  30. 2度の臓器搬送を要し冷阻血時間が長時間となった脳死肝移植の一例

    佐々木健吾, 阪本靖介, 内田孟, 濱野郁美, 重田孝信, 金澤寛之, 福田晃也, 小林めぐみ, 高原武志, 新田浩之, 若林剛, 笠原群生

    第30回日本小児肝臓病研究会　2013年7月13日

︎全件表示 ︎最初の5件までを表示

共同研究・競争的資金等の研究課題 1

  1. 新規腸疾患モデルの構築と難治性腸管吸収不全症の解明

    佐々木 健吾

    提供機関：Japan Society for the Promotion of Science

    制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    研究種目：Grant-in-Aid for Young Scientists (B)

    研究機関：National Center for Child Health and Development

    2016年4月 ～ 2019年3月

    詳細を見る 詳細を閉じる

    胆汁酸は小腸下部で再吸収され門脈を経由し肝臓へ運ばれ化学抱合を受けたのち再度小腸へ分泌される腸肝循環が行われる。腸管における脂肪吸収と腸管吸収機能不全との関連を分子レベルで解明していくため、単一遺伝子性疾患に着目し体外培養系の疾患モデル構築を行う。ヒト人工多能性（iPS）細胞技術を応用し、進行性家族性肝内胆汁うっ滞症1型（PFIC1）の疾患モデルを構築し腸管胆汁酸循環機構を分子レベルで解析する。PFIC1-iPS細胞から胆汁酸代謝関連遺伝子発現が備わった腸管組織を作製し疾患動態を解明する。本研究は、これまでに有用な疾患研究モデルがなかった難治性腸管吸収不全症にとって有用であり、同時に治療薬シーズ開発を効果的に行えるバイオモデル構築を目指す。PFIC1は膜タンパクであるATP8B1（ATPase, aminophospholipid transporter, class I, type 8B, member 1）遺伝子の異型接合性変異（常染色体劣性遺伝）により発症する。ATP8B1遺伝子の異常によりABCB11（ATP-binding cassette, sub-family B (MDR/TAP), member 1）やSLC10A2（solute carrier family 10 (sodium/bile acid cotransporter), member 2）など多くの胆汁酸トランスポーターの発現を2次的に低下させるが、その機序は全くわかっていない。小腸に発現している胆汁酸トランスポーターであるSLC10A2の発現も低下しており、吸収障害による下痢が生じる。代謝系酵素の発現とトランスポーターの発現解析を行い、特に、CYP3A4の酵素活性機能検証を行った結果、他のオルガノイドにはない酵素活性を示した。オルガノイド内腔でCYP3A4代謝産物の蓄積が確認できた。