東北大学研究者紹介

研究者詳細

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タカハシ　ジユン

高橋　潤

Jun Takahashi

所属

大学院医学系研究科　医科学専攻　内科病態学講座（循環器内科学分野）

職名

准教授

学位

博士（医学）（東北大学）

researchmap

https://researchmap.jp/read0121339

J-GLOBAL ID

200901094722684373

研究分野 1

ライフサイエンス / 循環器内科学 /

論文 283

Characteristics and In-Hospital Outcomes of Patients With Myocardial Infarction With Non-Obstructive Coronary Arteries - Insights From the Real-World JAMIR Database.

Sho Onuma, Jun Takahashi, Takashi Shiroto, Shigeo Godo, Kiyotaka Hao, Satoshi Honda, Kensaku Nishihira, Sunao Kojima, Misa Takegami, Yasuhiko Sakata, Tomonori Itoh, Tetsu Watanabe, Masafumi Watanabe, Morimasa Takayama, Tetsuya Sumiyoshi, Kazuo Kimura, Satoshi Yasuda

Circulation journal : official journal of the Japanese Circulation Society　2024年10月9日

DOI： 10.1253/circj.CJ-24-0422 　

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BACKGROUND: Few studies have investigated the clinical characteristics and in-hospital outcomes of patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) using real-world databases in the coronary intervention era. METHODS AND RESULTS: We conducted a retrospective analysis of 22,236 patients (mean [±SD] age 68±13 years, 23.4% female) enrolled in the Japan Acute Myocardial Infarction Registry (JAMIR) between 2011 and 2016. Based on urgent coronary angiography findings, 286 (1.3%) patients were diagnosed as MINOCA, and the remaining 21,950 (98.7%) as MI with obstructive coronary artery disease (MI-CAD). MINOCA patients were characterized by younger age, fewer coronary risk factors, lower rate of ST-elevation myocardial infarction, lower Killip classification, and lower peak creatinine phosphokinase levels than MI-CAD patients. In-hospital all-cause mortality did not differ between the MINOCA and MI-CAD groups (5.2% vs. 5.7%, respectively; P=0.82). Comparing cause-specific mortality, non-cardiac mortality was higher in the MINOCA than MI-CAD group (4.2% vs. 1.6%; P<0.01). Importantly, non-cardiac death was more prevalent among elderly (≥65 years) than younger (<65 years) patients in the MI-CAD group, whereas this trend was not observed in the MINOCA group. CONCLUSIONS: Analysis of the real-world JAMIR database revealed a relatively high prevalence of non-cardiac death among MINOCA patients, underscoring the need for comprehensive management to improve disease prognosis, particularly in younger patients.
Clinical impact of atrial fibrillation progression in patients with heart failure with preserved ejection fraction: A report from the CHART-2 Study. 国際誌

Tomohiro Ito, Takashi Noda, Kotaro Nochioka, Takashi Shiroto, Nobuhiko Yamamoto, Hiroyuki Sato, Takahiko Chiba, Yuhi Hasebe, Makoto Nakano, Hiroyuki Takahama, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa, Satoshi Yasuda

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology　2024年8月16日

DOI： 10.1093/europace/euae218 　

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AIMS: Atrial fibrillation (AF) frequently coexists with heart failure with preserved ejection fraction (HFpEF), and clinical outcomes of patients with AF vary depending on its subtype. While AF progression, characterized by the transition from paroxysmal AF to persistent AF, is sometimes observed, the incidence and clinical impact of AF progression in patients with HFpEF remain to be explored. METHODS AND RESULTS: We enrolled patients with HFpEF and paroxysmal AF from the Chronic Heart Failure Analysis and Registry in the Tohoku District-2 (CHART-2) Study. AF progression was defined as the transition from paroxysmal AF to persistent AF. A total of 718 patients (median age: 72 years, 36% were female) were enrolled. For a median follow-up of 6.0 years (interquartile range: 3.0-10.2 years), AF progression occurred in 105 patients (14.6%), with a cumulative incidence of 16.7% at 10 years. In the multivariable Cox proportional hazards model, previous hospitalization for heart failure (hazard ratio [HR] 1.74, 95% confidence interval [CI] 1.16-2.60; P=0.007) and left atrial diameter (per 5-mm increase) (HR 1.37, 95% CI 1.20-1.55; P<0.001) were significantly associated with AF progression. Furthermore, AF progression was significantly linked to worsening heart failure (adjusted HR 1.68, 95% CI 1.18-2.40; P=0.004). Notably, 27 cases (26%) of worsening heart failure occurred within one year following AF progression. CONCLUSION: In patients with HFpEF, AF progression is significantly associated with adverse outcomes, particularly worsening heart failure. An increased risk is observed in the early phases following progression to persistent AF. REGISTRATION: ClinicalTrials.gov Identifier: NCT00418041.
Clinical outcomes of adjusted-dose versus standard-dose prasugrel in East Asian patients with acute myocardial infarction. 国際誌

Satoshi Honda, Sangyeub Lee, Kyung Hoon Cho, Misa Takegami, Kensaku Nishihira, Sunao Kojima, Yasuhide Asaumi, Mike Saji, Jun Yamashita, Kiyoshi Hibi, Jun Takahashi, Yasuhiko Sakata, Morimasa Takayama, Tetsuya Sumiyoshi, Hisao Ogawa, Kazuo Kimura, Doo Sun Sim, Hyun Kuk Kim, Weon Kim, Youngkeun Ahn, Myung Ho Jeong, Satoshi Yasuda

International journal of cardiology　132197-132197　2024年5月30日

DOI： 10.1016/j.ijcard.2024.132197 　

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BACKGROUND: The comparative efficacy and safety of adjusted- and standard-dose prasugrel in East Asian patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) remain unclear. This study aimed to comparatively assess the ischaemic and bleeding outcomes of adjusted-dose (maintenance dose: 3.75 mg) and standard-dose (maintenance dose: 10 mg) prasugrel in East Asian patients with AMI undergoing PCI. METHODS: From a combined dataset sourced from nationwide AMI registries in Japan and South Korea (n = 17,118), patients treated with either adjusted- or standard-dose prasugrel were identified. Patients who did not undergo emergent PCI, those on oral anticoagulants, and those meeting the criteria of contraindication of prasugrel in South Korea (age ≥ 75 years, body weight < 60 kg, or history of stroke) were excluded. Major adverse cardiovascular events (MACE) and Thrombolysis in Myocardial Infarction (TIMI) major bleeding events were compared between the adjusted-dose (n = 1160) and standard-dose (n = 1086) prasugrel groups. RESULTS: Within the propensity-matched cohort (n = 702 in each group), no significant difference was observed in the in-hospital MACE between the adjusted- and standard-dose prasugrel groups (1.85% vs. 2.71%, odds ratio [OR] 0.68, 95% confidence interval [CI] 0.33-1.38, p = 0.286). However, the incidence of in-hospital major bleeding was significantly lower in the adjusted-dose prasugrel group than in the standard-dose group (0.43% vs. 1.71%, OR 0.25, 95% CI 0.07-0.88, p = 0.031). The cumulative 12-month incidence of MACE was equivalent in both groups (4.70% vs. 4.70%, OR 1.00, 95% CI 0.61-1.64, p = 1.000). CONCLUSIONS: Among East Asian patients with AMI undergoing PCI, those administered adjusted-dose prasugrel exhibited a lower risk of in-hospital bleeding events than those administered standard-dose prasugrel, while maintaining a comparable 1-year incidence of MACE.
Prognostic impact of heart failure admission in survivors of acute myocardial infarction. 国際誌

Satoshi Takeuchi, Satoshi Honda, Kensaku Nishihira, Sunao Kojima, Misa Takegami, Yasuhide Asaumi, Mike Saji, Jun Yamashita, Kiyoshi Hibi, Jun Takahashi, Yasuhiko Sakata, Morimasa Takayama, Tetsuya Sumiyoshi, Hisao Ogawa, Kazuo Kimura, Satoshi Yasuda

ESC heart failure　2024年4月29日

DOI： 10.1002/ehf2.14790 　

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AIMS: The incidence and prognosis of symptomatic heart failure following acute myocardial infarction (AMI) in the primary percutaneous coronary intervention era have rarely been reported in the literature. This study aimed to (i) determine the incidence of heart failure admission among AMI survivors, (ii) compare 1 year outcomes between patients with heart failure admission and those without, and (iii) identify the independent risk factors associated with heart failure admission. METHODS AND RESULTS: The Japan Acute Myocardial Infarction Registry is a prospective multicentre registry from which data on consecutively enrolled patients with AMI from 50 institutions between 2015 and 2017 were obtained. Among the 3411 patients enrolled, 3226 who survived until discharge were included in this study. The primary endpoint was all-cause mortality. The secondary endpoints were major adverse cardiovascular events (defined as cardiovascular mortality, non-fatal myocardial infarction, or non-fatal cerebral infarction) and major bleeding events corresponding to Bleeding Academic Research Consortium Type 3 or 5. Clinical outcomes were compared between the patients who were and were not admitted for heart failure. Over a median follow-up of 12 months, 124 patients (3.8%) were admitted due to heart failure. Independent risk factors for heart failure admission included older age, female sex, Killip class ≥2 on admission, left ventricular ejection fraction <40%, estimated glomerular filtration rate ≤30 mL/min/1.73 m2, a history of malignancy, and non-use of angiotensin-converting enzyme inhibitors at discharge. The cumulative incidence of all-cause mortality was significantly higher in the heart failure admission group than in the no heart failure admission group (11.3% vs. 2.5%, P < 0.001). The rates of major adverse cardiovascular events (16.9% vs. 2.7%, P < 0.001) and major bleeding (6.5% vs. 1.6%, P < 0.001) were significantly higher in the heart failure admission group. Heart failure admission was associated with a higher risk of all-cause mortality, even after adjusting for potential confounders (adjusted hazard ratio: 2.41, 95% confidence interval: 1.33-4.39, P = 0.004). CONCLUSIONS: Utilizing real-world data of the contemporary percutaneous coronary intervention era from the Japan Acute Myocardial Infarction Registry database, this study demonstrates that the heart failure admission of AMI survivors was significantly associated with higher all-cause mortality rates.
Age-stratified profiles and outcomes of patients with heart failure with preserved ejection fraction. 国際誌

Shinsuke Yamanaka, Kotaro Nochioka, Hideka Hayashi, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Satoshi Yasuda, Hiroaki Shimokawa

ESC heart failure　2024年4月16日

DOI： 10.1002/ehf2.14798 　

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AIMS: This study aimed to elucidate age-stratified clinical profiles and outcomes in patients with heart failure (HF) with preserved left ventricular ejection fraction (LVEF) (HFpEF). METHODS AND RESULTS: The Chronic Heart Failure Registry and Analysis in the Tohoku District-2 (CHART-2) Study included 2824 consecutive HFpEF patients with LVEF ≥ 50% (mean age 69.0 ± 12.3 years; 67.7% male) with a median follow-up of 9.8 years. We stratified them into five age groups: ≤54 (N = 349, 12.4%), 55-64 (N = 529, 18.7%), 65-74 (N = 891, 31.6%), 75-84 (N = 853, 30.2%), and ≥85 years (N = 202, 7.2%), and we categorized these age groups into younger (≤64 years) and older (≥65 years) groups. We compared the clinical profiles and outcomes of HFpEF patients across age groups. Younger HFpEF groups exhibited a male predominance, elevated body mass index (BMI), and poorly controlled diabetes (haemoglobin A1c > 7.0%). Older HFpEF groups were more likely to be female with multiple comorbidities, including coronary artery disease, hypertension, renal impairment, and atrial fibrillation. The positive association between elevated BMI and HFpEF was more pronounced with lower classes of age from ≥85 to ≤54 years, especially in males. With higher classes of age from ≤54 to ≥85 years, mortality rates increased, and HF death became proportionally more prevalent (Ptrend < 0.001), whereas sudden cardiac death (SCD) exhibited the opposite trend (Ptrend = 0.002). Poorly controlled diabetes emerged as the only predictor of SCD in the younger groups (adjusted hazard ratio 4.26; 95% confidence interval 1.45-12.5; P = 0.008). Multiple comorbidities were significantly associated with an increased risk of HF-related mortality in the older groups. CONCLUSIONS: Younger HFpEF patients (≤64 years) exhibit a male predominance, elevated BMI, and poorly controlled diabetes, highlighting the importance of glycaemic control in reducing SCD risk. Older HFpEF patients (≥65 years) are more likely to be female, with multiple comorbidities linked to an increased risk of HF-related mortality. These findings underscore the need for physicians to recognize age-related, distinct HFpEF phenotypes for personalized patient management.
左室駆出率が保たれた心不全患者における心房細動進行の臨床的影響 CHART-2 Studyからの知見(Clinical Impact of Atrial Fibrillation Progression in Heart Failure Patients with Preserved Left Ventricular Ejection Fraction: Insights from CHART-2 Study)

Ito Tomohiro, Noda Takashi, Nochioka Kotaro, Shirato Takashi, Yamamoto Nobuhiko, Sato Hiroyuki, Chiba Takahiko, Hasebe Yuhi, Takahama Hiroyuki, Nakano Makoto, Takahashi Jun, Shimokawa Hiroaki, Yasuda Satoshi

日本循環器学会学術集会抄録集　88回　PE58-5　2024年3月
出版者・発行元： (一社)日本循環器学会
ステージA/Bの発症前無症候性心不全におけるBMIと10年後の転帰との関連 CHART-2 Studyからの知見(Association of Body Mass Index with Ten-Year Outcomes in Pre-Clinical Asymptomatic Stage A/B Heart Failure: Insights from the CHART-2 Study)

高濱博幸, 後岡広太郎, 宮田敏, 林秀華, 井上巧, 薄田海, 大山宗馬, 白戸崇, 高橋潤, 下川宏明, 安田聡

日本循環器学会学術集会抄録集　88回　PJ011-1　2024年3月
出版者・発行元： (一社)日本循環器学会
慢性心不全における再入院頻度と予後への影響 CHART-2試験からの知見(Rehospitalization Frequency and Prognostic Implications in Chronic Heart Failure: Insights from the CHART-2 Study)

井上巧, 後岡広太郎, 宮田敏, 白戸崇, 林秀華, 大山宗馬, 薄田海, 高濱博幸, 高橋潤, 下川宏明, 安田聡

日本循環器学会学術集会抄録集　88回　PJ099-3　2024年3月
出版者・発行元： (一社)日本循環器学会
Association of Body Mass Index with Ten-Year Outcomes in Pre-Clinical Asymptomatic Stage A/B Heart Failure: Insights from the CHART-2 Study(タイトル和訳中)

高濱博幸, 後岡広太郎, 宮田敏, 林秀華, 井上巧, 薄田海, 大山宗馬, 白戸崇, 高橋潤, 下川宏明, 安田聡

日本循環器学会学術集会抄録集　88回　PJ011-1　2024年3月
出版者・発行元： (一社)日本循環器学会
Rehospitalization Frequency and Prognostic Implications in Chronic Heart Failure: Insights from the CHART-2 Study(タイトル和訳中)

井上巧, 後岡広太郎, 宮田敏, 白戸崇, 林秀華, 大山宗馬, 薄田海, 高濱博幸, 高橋潤, 下川宏明, 安田聡

日本循環器学会学術集会抄録集　88回　PJ099-3　2024年3月
出版者・発行元： (一社)日本循環器学会
Underuse of heart failure medications and poor long-term prognosis in chronic heart failure patients with polypharmacy - A report from the CHART-2 study. 国際誌

Takahide Fujihashi, Kotaro Nochioka, Satoshi Yasuda, Yasuhiko Sakata, Hideka Hayashi, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

International journal of cardiology. Heart & vasculature　50　101345-101345　2024年2月

DOI： 10.1016/j.ijcha.2024.101345 　

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BACKGROUND: In patients with chronic heart failure (CHF), comorbidities are often managed with multiple medications, characterized by polypharmacy, leading to increased risk of potentially inappropriate medication and adverse effects. METHODS: We studied 4,876 consecutive patients with CHF (Stage C/D, age 69.0 ± 12.3 years) in the CHART-2 study to evaluate the association among polypharmacy, underuse of HF medications, and all-cause death. Polypharmacy was defined as the daily use of ≥ 8 medications for the survival classification and regression tree analysis. RESULTS: The average number of medications was 10 in the polypharmacy group and 5 in the non-polypharmacy group, respectively. Over a median of 8.3 (4.1-11.7) years, the incidence rate of all-cause death was significantly higher in the polypharmacy group (n = 2,108) than in the non-polypharmacy group (57.3 % vs. 40.6 %; adjusted hazard ratio [aHR] 1.34 (95 %CI, 1.22-1.48), P < 0.001), even in age < 55 years (26.6 % vs. 14.3 %; adjusted hazard ratio [aHR] 1.61 (95 %CI, 1.04-2.50), P = 0.033). In patients with polypharmacy, those without renin-angiotensin system inhibitors (RAS-I) and/or beta-blockers (N = 1,023) were associated with increased incidence of all-cause death as compared with those with both medications (aHR 1.18; 95 %CI 1.04-1.35, P = 0.012). CONCLUSIONS: Polypharmacy was associated with poor long-term prognosis, even in younger patients with CHF. Among 4,876 patients with CHF, 1023 (20.9%) with polypharmacy and underuse of RAS-I and/or beta-blocker were associated with increased risk of all-cause death.
Long-term prognostic significance of history of cancer and atrial fibrillation in coronary artery disease. 国際誌

Kotaro Nochioka, Takashi Shiroto, Hideka Hayashi, Takumi Inoue, Kazuma Oyama, Kai Susukita, Hiroyuki Takahama, Jun Takahashi, Hiroaki Shimokawa, Satoshi Yasuda

International journal of cardiology. Heart & vasculature　49　101277-101277　2023年12月

DOI： 10.1016/j.ijcha.2023.101277 　

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BACKGROUND: Limited data exist on the prognostic significance of a history of cancer and atrial fibrillation (AF) in patients with coronary artery disease (CAD). This study aimed to evaluate the associations among a history of cancer, AF, and long-term prognosis in patients with CAD. METHODS: We studied 3,233 patients with CAD (69 ± 11 years; women, 23%) in a multicenter hospital-based cohort study, the CHART-2 and related a history of cancer and AF to cardiovascular outcomes with a median follow-up of 10.8 years. RESULTS: Of the 3,233 patients enrolled, 10.7% and 11.2% had a history of cancer and AF, respectively, while 2.8% had both. Patients with AF and a history of cancer were characterized by older age, male sex, and higher BNP levels. Anticoagulant use with warfarin or direct oral anticoagulants increased from 43% at baseline to 56% at 10 years in patients with CAD with AF and no history of cancer and increased from 49% to 83% in those with both. Patients with CAD with both comorbidities had a higher risk of a composite outcome including stroke, thrombosis, and major bleeding (Hazard Ratio [HRadjusted], 2.26; 1.50-3.40, P < 0.001). Furthermore, patients with both comorbidities had a higher risk of all-cause death (1.55; 95% confidence interval [CI] 1.12-2.12, P = 0.007) including cancer death (2.62; 1.51-4.54, P = 0.001), and new-onset heart failure (HF) requiring hospitalization (2.47; 1.54-3.96, P < 0.001). CONCLUSIONS: These results demonstrate that CAD patients with a history of cancer and AF have an increased risk of composite outcomes, including stroke, systemic thrombosis, major bleeding, all-cause death, cancer-related death, and new-onset HF.
Percutaneous Coronary Intervention for ST-elevation Myocardial Infarction Complicated by Cardiogenic Shock in a Super-aging Society. 国際誌

Kensaku Nishihira, Satoshi Honda, Misa Takegami, Sunao Kojima, Jun Takahashi, Tomonori Itoh, Tetsu Watanabe, Jun Yamashita, Mike Saji, Kenichi Tsujita, Morimasa Takayama, Tetsuya Sumiyoshi, Kazuo Kimura, Satoshi Yasuda

European heart journal. Acute cardiovascular care　2023年9月19日

DOI： 10.1093/ehjacc/zuad113 　

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AIMS: ST-segment elevation myocardial infarction complicated by cardiogenic shock (STEMICS) is associated with substantial mortality. As life expectancy increases, percutaneous coronary intervention (PCI) is being performed more frequently, even in elderly patients with acute myocardial infarction (AMI). This study sought to investigate the characteristics and impact of PCI on in-hospital mortality in patients with STEMICS. METHODS AND RESULTS: The Japan AMI Registry (JAMIR) is a retrospective, nationwide, real-world database. Among 46,242 patients with AMI hospitalized in 2011-2016, 2,760 patients with STEMICS (median age, 72 years) were studied. We compared 2,396 (86.8%) patients who underwent PCI with 364 (13.2%) patients who did not. The percentage of mechanical circulatory support use in patients with STEMICS was 69.3% and in-hospital mortality was 34.6%. Compared with patients who did not undergo PCI, patients undergoing PCI were younger and had a higher rate of intra-aortic balloon pump use. A higher proportion were male or current smokers. In-hospital mortality was significantly lower in the PCI group than in the no-PCI group (31.3% vs. 56.0%, P < 0.001). PCI was independently associated with lower in-hospital mortality (adjusted odds ratio [OR], 0.508; 95% confidence interval [CI], 0.347-0.744). In 789 (28.6%) patients aged ≥80 years, PCI was associated with fewer in-hospital cardiac deaths (adjusted OR, 0.524; 95% CI, 0.281-0.975), but was not associated with in-hospital mortality (adjusted OR, 0.564; 95% CI, 0.300-1.050). CONCLUSION: In Japan, PCI was effective in reducing in-hospital cardiac death in elderly patients with STEMICS. Age alone should not preclude potentially beneficial invasive therapy.
Pathophysiology and diagnostic pathway of myocardial infarction with non-obstructive coronary arteries. 国際誌

Jun Takahashi, Sho Onuma, Kiyotaka Hao, Shigeo Godo, Takashi Shiroto, Satoshi Yasuda

Journal of cardiology　2023年7月29日

DOI： 10.1016/j.jjcc.2023.07.014 　

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Myocardial infarction with non-obstructive coronary arteries (MINOCA) is a heterogeneous and diverse disease entity, which accounts for about 6 % of all acute myocardial infarction (AMI) cases. In patients with chest pain and acute myocardial injury detected by a highly sensitive troponin assay, the absence of epicardial coronary stenosis of 50 % or greater on angiography leads to the working diagnosis of MINOCA. The updated JCS/CVIT/JCC 2023 Guideline described MINOCA as a new disease concept and recommended a multimodality approach to uncovering the underlying causes of MINOCA. Cardiac magnetic resonance (CMR) is useful in not only making a definite diagnosis of MINOCA, but also excluding non-ischemic causes that mimic AMI such as takotsubo cardiomyopathy and myocarditis. Meanwhile, intracoronary imaging, particularly optical coherence tomography (OCT), enables us to evaluate precisely intracoronary morphological alterations including plaque disruption and spontaneous coronary artery dissection which are not revealed by angiographic findings alone. Recent studies have shown that an initial workup with the combination of CMR and OCT could provide a definite diagnosis in a significant percentage of patients suspected of MINOCA. Consecutively, patients with inconclusive results of a series of CMR and OCT implementation are eligible for assessing the potential for coronary functional abnormalities or blood coagulopathy as another factor involved in the development of MINOCA. Although uncovering the pathogenesis of MINOCA might be essential for establishing an individualized treatment approach, significant knowledge gaps in terms of secondary prevention strategies for MINOCA focusing on the improvement of long-term prognosis remain to be overcome. In this review, we summarize our current understanding of MINOCA and highlight contemporary diagnostic approaches for patients with suspected MINOCA.
Disparity of Performance Measure by Door-to-Balloon Time Between a Rural and Urban Area for Management of Patients With ST-Segment Elevation Myocardial Infarction - Insights From the Nationwide Japan Acute Myocardial Infarction Registry.

Kento Fukui, Jun Takahashi, Kiyotaka Hao, Satoshi Honda, Kensaku Nishihira, Sunao Kojima, Misa Takegami, Yasuhiko Sakata, Tomonori Itoh, Tetsu Watanabe, Morimasa Takayama, Tetsuya Sumiyoshi, Kazuo Kimura, Satoshi Yasuda

Circulation journal : official journal of the Japanese Circulation Society　87　(5)　648-656　2023年4月25日

DOI： 10.1253/circj.CJ-22-0454 　

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BACKGROUND: Although a door-to-balloon (D2B) time ≤90 min is recognized as a key indicator of timely reperfusion for patients with ST-segment elevation myocardial infarction (STEMI), it is unclear whether regional disparities in the prognostic value of D2B remain in contemporary Japan.Methods and Results: We retrospectively analyzed 17,167 STEMI patients (mean [±SD] age 68±13 years, 77.6% male) undergoing primary percutaneous coronary intervention. With reference to the Japanese median population density of 1,147 people/km2, patients were divided into 2 groups: rural (n=6,908) and urban (n=10,259). Compared with the urban group, median D2B time was longer (70 vs. 62 min; P<0.001) and the rate of achieving a D2B time ≤90 min was lower (70.7% vs. 75.4%; P<0.001) in the rural group. In-hospital mortality was lower for patients with a D2B time ≤90 min than >90 min, regardless of residential area, whereas multivariable analysis identified prolonged D2B time as a predictor of in-hospital death only in the rural group (adjusted odds ratio 1.57; 95% confidence interval 1.18-2.09; P=0.002). Importantly, the rural-urban disparity in in-hospital mortality emerged most distinctively among patients with Killip Class IV and a D2B time >90 min. CONCLUSIONS: These data suggest that there is a substantial rural-urban gap in the prognostic significance of D2B time among STEMI patients, especially those with cardiogenic shock and a prolonged D2B time.
JCS/CVIT/JCC 2023 Guideline Focused Update on Diagnosis and Treatment of Vasospastic Angina (Coronary Spastic Angina) and Coronary Microvascular Dysfunction.

Seiji Hokimoto, Koichi Kaikita, Satoshi Yasuda, Kenichi Tsujita, Masaharu Ishihara, Tetsuya Matoba, Yasushi Matsuzawa, Yoshiaki Mitsutake, Yoshihide Mitani, Toyoaki Murohara, Takashi Noda, Koichi Node, Teruo Noguchi, Hiroshi Suzuki, Jun Takahashi, Yasuhiko Tanabe, Atsushi Tanaka, Nobuhiro Tanaka, Hiroki Teragawa, Takanori Yasu, Michihiro Yoshimura, Yasuhide Asaumi, Shigeo Godo, Hiroki Ikenaga, Takahiro Imanaka, Kohei Ishibashi, Masanobu Ishii, Takayuki Ishihara, Yunosuke Matsuura, Hiroyuki Miura, Yasuhiro Nakano, Takayuki Ogawa, Takashi Shiroto, Hirofumi Soejima, Ryu Takagi, Akihito Tanaka, Atsushi Tanaka, Akira Taruya, Etsuko Tsuda, Kohei Wakabayashi, Kensuke Yokoi, Toru Minamino, Yoshihisa Nakagawa, Shozo Sueda, Hiroaki Shimokawa, Hisao Ogawa

Circulation journal : official journal of the Japanese Circulation Society　87　(6)　879-936　2023年3月10日

DOI： 10.1253/circj.CJ-22-0779 　
Coronary Microvascular Spasm: Clinical Presentation and Diagnosis. 国際誌

Shigeo Godo, Jun Takahashi, Takashi Shiroto, Satoshi Yasuda, Hiroaki Shimokawa

European cardiology　18　e07　2023年

DOI： 10.15420/ecr.2022.50 　

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Professor Maseri pioneered the research and treatment of coronary vasomotion abnormalities represented by coronary vasospasm and coronary microvascular dysfunction (CMD). These mechanisms can cause myocardial ischaemia even in the absence of obstructive coronary artery disease, and have been appreciated as an important aetiology and therapeutic target with major clinical implications in patients with ischaemia with non-obstructive coronary artery disease (INOCA). Coronary microvascular spasm is one of the key mechanisms responsible for myocardial ischaemia in patients with INOCA. Comprehensive assessment of coronary vasomotor reactivity by invasive functional coronary angiography or interventional diagnostic procedure is recommended to identify the underlying mechanisms of myocardial ischaemia and to tailor the best treatment and management based on the endotype of INOCA. This review highlights the pioneering works of Professor Maseri and contemporary research on coronary vasospasm and CMD with reference to endothelial dysfunction, Rho-kinase activation and inflammation.
Mechanisms of Coronary Artery Spasm. 国際誌

Kensuke Nishimiya, Jun Takahashi, Kazuma Oyama, Yasuharu Matsumoto, Satoshi Yasuda, Hiroaki Shimokawa

European cardiology　18　e39　2023年

DOI： 10.15420/ecr.2022.55 　

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Recent clinical trials have highlighted that percutaneous coronary intervention in patients with stable angina provides limited additional benefits on top of optimal medical therapy. This has led to much more attention being paid to coronary vasomotion abnormalities regardless of obstructive or non-obstructive arterial segments. Coronary vasomotion is regulated by multiple mechanisms that include the endothelium, vascular smooth muscle cells (VSMCs), myocardial metabolic demand, autonomic nervous system and inflammation. Over the years, several animal models have been developed to explore the central mechanism of coronary artery spasm. This review summarises the landmark studies on the mechanisms of coronary vasospasm demonstrating the central role of Rho-kinase as a molecular switch of VSMC hypercontraction and the important role of coronary adventitial inflammation for Rho-kinase upregulation in VSMCs.
The influence of COVID-19 pandemic on management of acute myocardial infarction in Japan; Insight from the Miyagi AMI Registry Study. 国際誌

Kiyotaka Hao, Jun Takahashi, Koichi Sato, Akira Suda, Tomohiko Sindo, Shigeo Godo, Kensuke Nishimiya, Yoku Kikuchi, Takashi Shiroto, Satoshi Yasuda

International journal of cardiology. Heart & vasculature　43　101116-101116　2022年12月

DOI： 10.1016/j.ijcha.2022.101116 　

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Due to the coronavirus disease 2019 (COVID-19) pandemic, the first state of emergency had been declared from April 7 to May 25, 2020, in Japan. This pandemic might affect the management for patients with acute myocardial infarction (AMI). Method and Results: To evaluate the critical care and outcomes of AMI patients during the COVID-19 outbreak, we examined the patients with AMI hospitalized in 2020 (n = 1186) and those in 2017-2019 (n = 4877) using a database of the Miyagi AMI Registry Study. The door-to-device time under the emergency declaration became longer as compared with that of the same period in 2017-2019 [83(65-111) vs 74(54-108) min, p = 0.04]. Importantly, the time delay was noted in only patients with Killip class I on arrival, but not in those with Killip class II-IV. Meanwhile, there were no significant changes in the duration from the symptom onset to hospital arrival, the use rate of ambulance and the performance rate of primary percutaneous coronary intervention before and after the COVID-19 outbreak. Eventually, in-hospital mortality had not deteriorated under the state of emergency (6.7 vs 7.8 %, P = 0.69). Conclusion: The emergence of the COVID-19 outbreak seemed to affect AMI management and highlight understanding the barriers to cardiovascular critical care.
高齢者における循環器疾患に対する応用薬理慢性心不全患者における脳由来成長因子(BDNF)と脳灰白質量との関連慢性心不全における脳の構造・機能に関する縦断研究(B-HeFT2)

鈴木秀明, 松本泰治, 大田英揮, 杉村宏一郎, 後岡広太郎, 高橋潤, 宮田敏, 古川勝敏, 福本義弘, 瀧靖之, 下川宏明, 安田聡

応用薬理　102　(5-6)　123-123　2022年8月
出版者・発行元：応用薬理研究会
ISSN：0300-8533
バルーン拡張型TAVI弁留置時にkissing balloon inflationによって左冠動脈から大動脈に突出したステントの変形を回避し得た超高リスク大動脈弁狭窄症の一例

高橋亮吉, 西宮健介, 羽尾清貴, 菊地翼, 神戸茂雄, 勝田祐子, 進藤智彦, 白戸崇, 熊谷紀一郎, 高橋潤, 齋木佳克, 安田聡

日本心血管インターベンション治療学会抄録集　30回　[YIA48-8]　2022年7月
出版者・発行元： (一社)日本心血管インターベンション治療学会
Multimodal approach for isolated cardiac sarcoidosis. 国際誌

Shigeo Godo, Yuhi Hasebe, Jun Takahashi, Hiroaki Shimokawa, Satoshi Yasuda

European heart journal. Case reports　6　(7)　ytac291　2022年7月

DOI： 10.1093/ehjcr/ytac291 　
術前フレイルはTAVI後せん妄の最大の予測因子である TAVI半年後の機能予後との関連性

竹内雅史, 菊地翼, 羽尾清貴, 西宮健介, 高橋潤, 安田聡

日本心血管インターベンション治療学会抄録集　30回　[CO033]-[CO033]　2022年7月
出版者・発行元： (一社)日本心血管インターベンション治療学会
バルーン拡張型TAVI弁留置時にkissing balloon inflationによって左冠動脈から大動脈に突出したステントの変形を回避し得た超高リスク大動脈弁狭窄症の一例

高橋亮吉, 西宮健介, 羽尾清貴, 菊地翼, 神戸茂雄, 勝田祐子, 進藤智彦, 白戸崇, 熊谷紀一郎, 高橋潤, 齋木佳克, 安田聡

日本心血管インターベンション治療学会抄録集　30回　[YIA48-8]　2022年7月
出版者・発行元： (一社)日本心血管インターベンション治療学会
Impact of statins in patients with vasospastic angina: A multicenter registry study of the Japanese Coronary Spasm Association. 国際誌

Hiroyoshi Mori, Jun Takahashi, Koichi Sato, Satoshi Miyata, Yusuke Takagi, Ryusuke Tsunoda, Tetsuya Sumiyoshi, Motoyuki Matsui, Yasuhiko Tanabe, Shozo Sueda, Shin-Ichi Momomura, Koichi Kaikita, Satoshi Yasuda, Hisao Ogawa, Hiroaki Shimokawa, Hiroshi Suzuki

Journal of cardiology　80　(3)　226-231　2022年5月21日

DOI： 10.1016/j.jjcc.2022.03.009 　

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BACKGROUND: Statins are generally used for patients with coronary artery disease. However, the impact of statins in patients with vasospastic angina (VSA) is not fully understood. METHODS: In a multicenter registry study of the Japanese Coronary Spasm Association (n = 1429), patients with or without statins were compared. The primary endpoint was major adverse cardiac events (MACEs), defined as cardiac death, non-fatal myocardial infarction, unstable angina, heart failure, and appropriate implantable cardioverter defibrillator shock. Propensity score matching and a multivariable Cox proportional hazard model were used to adjust for selection bias in treatment and potential confounding factors. RESULTS: In the whole population, 469 patients received statins, while 960 patients did not receive statins. Patients with statins had a greater prevalence of comorbidities, including hypertension, diabetes, dyslipidemia, and smoking, in comparison to those without statins. The prevalence rates of previous myocardial infarction, significant organic stenosis, and medication use (including calcium channel blockers, angiotensin-converting enzyme inhibitor/angiotensin receptor blockers, and beta blockers) were greater in patients with statins than in those without statins. After propensity matching (n = 211 for both groups), a Kaplan-Meier curve analysis revealed that the incidence of MACE was comparable between patients with and without statins (p = 0.686). MACEs occurred in 6.0% of patients with statins and in 5.9% of those without statins (p = 0.98). CONCLUSION: In this multicenter registry study, statin therapy did not reduce clinical events in VSA patients.
Prognostic impact of a history of cancer and atrial fibrillation in antithrombotic therapy for chronic heart failure. 国際誌

Kotaro Nochioka, Satoshi Yasuda, Yasuhiko Sakata, Takashi Shiroto, Hideka Hayashi, Jun Takahashi, Hiroyuki Takahama, Satoshi Miyata, Hiroaki Shimokawa

ESC heart failure　2022年4月17日

DOI： 10.1002/ehf2.13941 　

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AIMS: This study aimed to examine the prognostic significance of a history of cancer and atrial fibrillation (AF) in antithrombotic therapy for patients with chronic heart failure (CHF). METHODS AND RESULTS: We enrolled consecutive 4876 CHF patients (69 ± 12 years; women, 31.9%) in our multicentre, hospital-based cohort study, the Chronic Heart Failure Analysis and Registry in the Tohoku District-2 (CHART-2), with a median follow-up of 8.7 years. Among them, 14% and 41% had a history of cancer and AF, respectively. AF patients with a history of cancer were older, more frequently men. History of cancer was not statistically associated with higher rate of composite of stroke, systemic thrombosis, and major bleeding defined by International Society on Thrombosis and Haemostasis [Fine-Gray sub-distribution hazard ratio (sHR) accounting for the competing risk of all-cause death, 0.91; 95% confidence interval (CI), 0.56-1.48; P = 0.715]. The patients with history of cancer and AF had a heightened risk for the composite of stroke, systemic thrombosis, and major bleeding (sHR, 1.64; 95% CI, 1.04-2.60; P = 0.033), especially in those aged >75 years (sHR, 2.14; 95% CI, 1.01-4.53; P = 0.046) and those with ischaemic heart disease (IHD; 2.48; 1.30-4.72; P = 0.006). Furthermore, 36% of AF patients with a history of cancer did not receive anticoagulant therapy. CONCLUSIONS: The CHF patients with history of cancer and AF had higher risk for stroke, systemic thrombosis, and major bleeding, especially in the elderly and those with IHD, but considerable number of the patients did not receive anticoagulant therapy, indicating the need for better optimal anticoagulation strategy.
Effect of Infarction-Related Artery Location on Clinical Outcome of Patients With Acute Myocardial Infarction in the Contemporary Era of Percutaneous Coronary Intervention - Subanalysis From the Prospective Japan Acute Myocardial Infarction Registry (JAMIR).

Seiji Koga, Satoshi Honda, Koji Maemura, Kensaku Nishihira, Sunao Kojima, Misa Takegami, Yasuhide Asaumi, Jun Yamashita, Mike Saji, Masami Kosuge, Jun Takahashi, Yasuhiko Sakata, Morimasa Takayama, Tetsuya Sumiyoshi, Hisao Ogawa, Kazuo Kimura, Satoshi Yasuda

Circulation journal : official journal of the Japanese Circulation Society　86　(4)　651-659　2022年3月25日

DOI： 10.1253/circj.CJ-21-0698 　

ISSN：1346-9843

eISSN：1347-4820
80歳以上と80歳未満の患者で比較した経カテーテル的大動脈弁置換術の長期死亡率(Comparison of Long-term Mortality of Transcatheter Aortic Valve Implantation between Patients Aged ≧80 Years and those <80 Years)

菊地翼, 高橋潤, 羽尾清貴, 西宮健介, 神戸茂雄, 勝田祐子, 須田彬, 進藤智彦, 白戸崇, 熊谷紀一郎, 齋木佳克, 安田聡

日本循環器学会学術集会抄録集　86回　PL10-2　2022年3月
出版者・発行元： (一社)日本循環器学会
急性心筋梗塞の現状と院内・院外の死亡率低下に向けた取り組み急性心筋梗塞後の心不全による再入院の頻度、リスクファクター、予後日本AMIレジストリ(JAMIR)からの知見(Frequency, Risk Factors and Prognosis of Heart Failure Readmission after Acute Myocardial Infarction: Insight from the Japan AMI Registry(JAMIR))

竹内智, 本田怜史, 西平賢作, 小島淳, 竹上未紗, 浅海泰栄, 佐地真育, 山下淳, 小菅雅美, 高橋潤, 坂田泰彦, 高山守正, 住吉徹哉, 小川久雄, 安田聡

日本循環器学会学術集会抄録集　86回　SY12-4　2022年3月
出版者・発行元： (一社)日本循環器学会
急性心筋梗塞の現状と院内・院外の死亡率低下に向けた取り組み(Frequency, Risk Factors and Prognosis of Heart Failure Readmission after Acute Myocardial Infarction: Insight from the Japan AMI Registry(JAMIR))

竹内智, 本田怜史, 西平賢作, 小島淳, 竹上未紗, 浅海泰栄, 佐地真育, 山下淳, 小菅雅美, 高橋潤, 坂田泰彦, 高山守正, 住吉徹哉, 小川久雄, 安田聡

日本循環器学会学術集会抄録集　86回　SY12-4　2022年3月
出版者・発行元： (一社)日本循環器学会
Isolated cardiac sarcoidosis associated with coronary vasomotion abnormalities: a case report. 国際誌

Shigeo Godo, Yuhi Hasebe, Jun Takahashi, Hiroaki Shimokawa, Satoshi Yasuda

European heart journal. Case reports　6　(2)　ytac083　2022年2月

DOI： 10.1093/ehjcr/ytac083 　

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BACKGROUND : Cardiac sarcoidosis is a chronic, inflammatory disease that can affect the heart and often results in heart failure and lethal arrhythmias. A multimodality imaging approach without endomyocardial biopsy allows for the diagnosis of isolated cardiac sarcoidosis. Coronary vasomotion abnormalities are highly prevalent in various cardiovascular and inflammatory diseases. It remains unknown whether active myocardial inflammation due to cardiac sarcoidosis is associated with coronary vasomotion abnormalities. CASE SUMMARY : A 68-year-old man without a past medical history experienced an out-of-hospital cardiac arrest due to ventricular fibrillation and was successfully resuscitated without neurologic sequelae. Coronary angiography showed normal coronary arteries; however, intracoronary acetylcholine provocation testing demonstrated both epicardial coronary and coronary microvascular spasm. He was diagnosed with isolated cardiac sarcoidosis by fulfilling the diagnostic criteria proposed by the Japanese Circulation Society 2016 diagnostic guidelines, including fatal ventricular arrhythmia, focal left ventricular wall asynergy, increased myocardial fluorodeoxyglucose uptake by positron emission tomography, and late gadolinium enhancement by cardiac magnetic resonance in the heart. He was treated with calcium-channel blocker for coronary artery spasm and prednisolone for cardiac sarcoidosis and underwent implantation of an implantable cardioverter-defibrillator for secondary prevention. Following the treatment, the severity of coronary artery spasm was reduced along with regression of the myocardial inflammation. DISCUSSION : Epicardial coronary artery and coronary microvascular spasm can be accompanied by active myocardial inflammation of isolated cardiac sarcoidosis, and the treatment with corticosteroid and calcium-channel blocker may be effective for relieving the severity of coronary artery spasm in association with regression of myocardial inflammation of the disease.
Prediction of the development of delirium after transcatheter aortic valve implantation using preoperative brain perfusion SPECT. 国際誌

Masashi Takeuchi, Hideaki Suzuki, Yasuharu Matsumoto, Yoku Kikuchi, Kentaro Takanami, Toshihiro Wagatsuma, Jun Sugisawa, Satoshi Tsuchiya, Kensuke Nishimiya, Kiyotaka Hao, Shigeo Godo, Tomohiko Shindo, Takashi Shiroto, Jun Takahashi, Kiichiro Kumagai, Masahiro Kohzuki, Kei Takase, Yoshikatsu Saiki, Satoshi Yasuda, Hiroaki Shimokawa

PloS one　17　(11)　e0276447　2022年

DOI： 10.1371/journal.pone.0276447 　

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OBJECTIVES: Delirium is an important prognostic factor in postoperative patients undergoing cardiovascular surgery and intervention, including transcatheter aortic valve implantation (TAVI). However, delirium after transcatheter aortic valve implantation (DAT) is difficult to predict and its pathophysiology is still unclear. We aimed to investigate whether preoperative cerebral blood flow (CBF) is associated with DAT and, if so, whether CBF measurement is useful for predicting DAT. METHODS: We evaluated CBF in 50 consecutive patients before TAVI (84.7±4.5 yrs., 36 females) using 99mTc ethyl cysteinate dimer single-photon emission computed tomography. Preoperative CBF of the DAT group (N = 12) was compared with that of the non-DAT group (N = 38) using whole brain voxel-wise analysis with SPM12 and region of interest-based analysis with the easy-Z score imaging system. Multivariable logistic regression analysis with the presence of DAT was used to create its prediction model. RESULTS: The whole brain analysis showed that preoperative CBF in the insula was lower in the DAT than in the non-DAT group (P<0.05, family-wise error correction). Decrease extent ratio in the insula of the DAT group (17.6±11.5%) was also greater relative to that of the non-DAT group (7.0±11.3%) in the region of interest-based analysis (P = 0.007). A model that included preoperative CBF in the insula and conventional indicators (frailty index, short physical performance battery and mini-mental state examination) showed the best predictive power for DAT (AUC 0.882). CONCLUSIONS: These results suggest that preoperative CBF in the insula is associated with DAT and may be useful for its prediction.
Usefulness of hybrid assessment for coronary functional abnormalities by non-invasive and invasive techniques. 国際誌

Jun Takahashi, Hiroaki Shimokawa, Satoshi Yasuda

International journal of cardiology　345　24-25　2021年12月15日

DOI： 10.1016/j.ijcard.2021.10.023 　
Endothelium in Coronary Macro- and Microvascular Diseases. 国際誌

Shigeo Godo, Jun Takahashi, Satoshi Yasuda, Hiroaki Shimokawa

Journal of cardiovascular pharmacology　2021年11月29日

DOI： 10.1097/FJC.0000000000001089 　

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ABSTRACT: The endothelium plays a pivotal role in the regulation of vascular tone by synthesizing and liberating endothelium-derived relaxing factors inclusive of vasodilator prostaglandins (e.g. prostacyclin), nitric oxide (NO), and endothelium-dependent hyperpolarization (EDH) factors in a distinct blood vessel-size dependent manner. Large conduit arteries are predominantly regulated by NO and small resistance arteries by EDH factors. Accumulating evidence over the past few decades has demonstrated that endothelial dysfunction and coronary vasomotion abnormalities play crucial roles in the pathogenesis of various cardiovascular diseases. Structural and functional alterations of the coronary microvasculature have been coined as coronary microvascular dysfunction (CMD), which is highly prevalent and associated with adverse clinical outcomes in many clinical settings. The major mechanisms of coronary vasomotion abnormalities include enhanced coronary vasoconstrictive reactivity at epicardial and microvascular levels, impaired endothelium-dependent and -independent coronary vasodilator capacities, and elevated coronary microvascular resistance caused by structural factors. Recent experimental and clinical research has highlighted CMD as the systemic small artery disease beyond the heart, emerging modulators of vascular functions, novel insight into the pathogenesis of cardiovascular diseases associated with CMD, and potential therapeutic interventions to CMD with major clinical implications. Herein, we will summarize the current knowledge on the endothelial modulation of vascular tone as well as the pathogenesis of coronary macro- and microvascular diseases from bench to bedside, with a special emphasis placed on the mechanisms and clinical implications of CMD.
Effect of Low Body Mass Index on the Clinical Outcomes of Japanese Patients With Acute Myocardial Infarction - Results From the Prospective Japan Acute Myocardial Infarction Registry (JAMIR).

Hiroaki Yokoyama, Hirofumi Tomita, Satoshi Honda, Kensaku Nishihira, Sunao Kojima, Misa Takegami, Yasuhide Asaumi, Jun Yamashita, Mike Saji, Masami Kosuge, Jun Takahashi, Yasuhiko Sakata, Morimasa Takayama, Tetsuya Sumiyoshi, Hisao Ogawa, Kazuo Kimura, Satoshi Yasuda

Circulation journal : official journal of the Japanese Circulation Society　86　(4)　632-639　2021年11月20日

DOI： 10.1253/circj.CJ-21-0705 　

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BACKGROUND: Acute myocardial infarction (AMI) patients with low body mass index (BMI) exhibit worse clinical outcomes than obese patients; however, to our knowledge, no prospective, nationwide study has assessed the effect of BMI on the clinical outcomes of AMI patients.Methods and Results:In this multi-center, prospective, nationwide Japanese trial, 2,373 AMI patients who underwent emergent percutaneous coronary intervention within 12 h of onset from the Japanese AMI Registry (JAMIR) were identified. Patients were divided into the following 4 groups based on their BMI at admission: Q1 group (BMI <18.5 kg/m2, n=133), Q2 group (18.5≤BMI<25.0 kg/m2, n=1,424), Q3 group (25.0≤BMI<30.0 kg/m2, n=672), and Q4 group (30.0 kg/m2≤BMI, n=144). The primary endpoint was all-cause death, and the secondary endpoint was a composite of cardiovascular death, non-fatal myocardial infarction (MI), and non-fatal stroke. The median follow-up period was 358 days. Q1 patients were older and had lower prevalence of coronary risk factors. Q1 patients also had higher all-cause mortality and higher incidence of secondary endpoints than normal-weight or obese AMI patients. Multivariate analysis showed that low BMI (Q1 group) was an independent predictor for primary endpoint. CONCLUSIONS: AMI patients with low BMI had fewer coronary risk factors but worse clinical outcomes than normal-weight or obese patients.
Measurement of myocardial lactate production for diagnosis of coronary microvascular spasm

Jun Takahashi, Akira Suda, Satoshi Yasuda, Hiroaki Shimokawa

Journal of Visualized Experiments　2021　(175)　2021年9月1日
出版者・発行元： Journal of Visualized Experiments
DOI： 10.3791/62558 　

ISSN：1940-087X
Characteristics and clinical outcomes of patients with de-escalation from prasugrel to clopidogrel after acute myocardial infarction - Insights from the prospective Japan Acute Myocardial Infarction Registry (JAMIR). 国際誌

Satoshi Honda, Kensaku Nishihira, Sunao Kojima, Misa Takegami, Yasuhide Asaumi, Makoto Suzuki, Masami Kosuge, Jun Takahashi, Yasuhiko Sakata, Morimasa Takayama, Tetsuya Sumiyoshi, Hisao Ogawa, Kazuo Kimura, Satoshi Yasuda

Journal of cardiology　78　(2)　99-106　2021年8月

DOI： 10.1016/j.jjcc.2021.03.001 　

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BACKGROUND: De-escalation of P2Y12 inhibitor may occur for various clinical reasons in patients with acute myocardial infarction (AMI). We aimed to assess the characteristics and outcomes of patients who underwent a de-escalation strategy in real-world clinical practice. METHODS AND RESULTS: We studied 2604 AMI patients initially treated with prasugrel using the Japan Acute Myocardial Infarction Registry (JAMIR) database. Of these, 110 (4%) were discharged on clopidogrel [de-escalation group; switching 4 days after admission (median)] and the remaining 2494 continued prasugrel at discharge (continuation group). The de-escalation group had higher incidence of heart failure or history of cerebrovascular disease, and were more likely to receive mechanical circulatory support, and oral anticoagulation than the continuation group. During mean follow-up of 309±133 days post-discharge, no significant differences were observed in ischemic events (2.2% vs. 2.8%, p = 0.74) or major bleeding (1.1% vs. 1.6%, p = 0.72) between the de-escalation and continuation groups. CONCLUSIONS: Although, patients with de-escalation from prasugrel to clopidogrel had higher bleeding risk profile than those continued on prasugrel, post discharge ischemic and bleeding events were similar between patients with and without de-escalation. De-escalation strategy may be an option for AMI patients with high risk for bleeding.
Clinical characteristics and prognosis of patients with microvascular angina: an international and prospective cohort study by the Coronary Vasomotor Disorders International Study (COVADIS) Group. 国際誌

Hiroaki Shimokawa, Akira Suda, Jun Takahashi, Colin Berry, Paolo G Camici, Filippo Crea, Javier Escaned, Tom Ford, Eric Yii, Juan Carlos Kaski, Takahiko Kiyooka, Puja K Mehta, Peter Ong, Yukio Ozaki, Carl Pepine, Ornella Rimoldi, Basmah Safdar, Udo Sechtem, Kenichi Tsujita, Satoshi Yasuda, John F Beltrame, C Noel Bairey Merz

European heart journal　42　(44)　4592-4600　2021年5月26日

DOI： 10.1093/eurheartj/ehab282 　

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AIMS: To provide multi-national, multi-ethnic data on the clinical characteristics and prognosis of patients with microvascular angina (MVA). METHODS AND RESULTS: The Coronary Vasomotor Disorders International Study Group proposed the diagnostic criteria for MVA. We prospectively evaluated the clinical characteristics of patients according to these criteria and their prognosis. The primary endpoint was the composite of major cardiovascular events (MACE), verified by institutional investigators, which included cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, and hospitalization due to heart failure or unstable angina. During the period from 1 July 2015 to 31 December 2018, 686 patients with MVA were registered from 14 institutes in 7 countries from 4 continents. Among them, 64% were female and the main ethnic groups were Caucasians (61%) and Asians (29%). During follow-up of a median of 398 days (IQR 365-744), 78 MACE occurred (6.4% in men vs. 8.6% in women, P = 0.19). Multivariable Cox proportional hazard analysis disclosed that hypertension and previous history of coronary artery disease (CAD), including acute coronary syndrome and stable angina pectoris, were independent predictors of MACE. There was no sex or ethnic difference in prognosis, although women had lower Seattle Angina Questionnaire scores than men (P < 0.05). CONCLUSIONS: This first international study provides novel evidence that MVA is an important health problem regardless of sex or ethnicity that a diagnosis of MVA portends a substantial risk for MACE associated with hypertension and previous history of CAD, and that women have a lower quality of life than men despite the comparable prognosis.
Impact of bleeding on mortality in patients with acute myocardial infarction complicated by cardiogenic shock. 国際誌

Kensaku Nishihira, Satoshi Honda, Misa Takegami, Sunao Kojima, Yasuhide Asaumi, Makoto Suzuki, Masami Kosuge, Jun Takahashi, Yasuhiko Sakata, Morimasa Takayama, Tetsuya Sumiyoshi, Hisao Ogawa, Kazuo Kimura, Satoshi Yasuda

European heart journal. Acute cardiovascular care　10　(4)　388-396　2021年5月25日

DOI： 10.1093/ehjacc/zuab014 　

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AIMS: Acute myocardial infarction complicated by cardiogenic shock (AMICS) is associated with substantial mortality, although there are limited data available on bleeding in this critical condition. This study sought to investigate the incidence and impact of major in-hospital bleeding on all-cause mortality in patients with AMICS who undergo percutaneous coronary intervention (PCI). METHODS AND RESULTS: Between 2015 and 2017, a total of 3411 patients hospitalized within 24 h after symptom onset were prospectively enrolled in the Japan Acute Myocardial Infarction Registry (JAMIR) and followed up for a median of 293 (interquartile range, 22-375) days. AMICS developed in 335 (9.8%) patients (mean age, 71.3 ± 13.6 years). Overall, the rate of major in-hospital bleeding (Bleeding Academic Research Consortium types 3 and 5) and in-hospital mortality was 14.6% and 28.7%, respectively. The majority of major in-hospital bleeding (73.5%) occurred within 48 h after PCI. Compared to patients without major in-hospital bleeding, those with it had higher rates of renal failure, left main coronary artery culprit lesion, and intra-aortic balloon pump or extracorporeal membrane oxygenation support, and had longer door-to-device time. The cumulative incidence of 1-year all-cause mortality was significantly higher in the major bleeding group compared to the non-major bleeding group (63.8% vs. 25.5%; log-rank P < 0.001). After adjusting for confounders, major in-hospital bleeding was independently associated with increased all-cause mortality (hazard ratio, 1.70; 95% confidence interval, 1.08-2.69). CONCLUSIONS: These findings of JAMIR indicate that major in-hospital bleeding is associated with all-cause mortality in patients with AMICS who undergo PCI.
Coronary Microvascular Dysfunction. 国際誌

Shigeo Godo, Akira Suda, Jun Takahashi, Satoshi Yasuda, Hiroaki Shimokawa

Arteriosclerosis, thrombosis, and vascular biology　41　(5)　1625-1637　2021年5月5日

DOI： 10.1161/ATVBAHA.121.316025 　

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[Figure: see text].
Beneficial effects of exercise training on physical performance in patients with vasospastic angina. 国際誌

Jun Sugisawa, Yasuharu Matsumoto, Masashi Takeuchi, Akira Suda, Satoshi Tsuchiya, Kazuma Ohyama, Kensuke Nishimiya, Mina Akizuki, Koichi Sato, Shoko Ohura, Hideki Ota, Shohei Ikeda, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Yasuhiko Sakata, Kei Takase, Masahiro Kohzuki, Hiroaki Shimokawa

International journal of cardiology　328　14-21　2021年4月1日

DOI： 10.1016/j.ijcard.2020.12.003 　

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AIMS: In vasospastic angina (VSA), coronary vasomotion abnormalities could develop not only in epicardial coronary arteries but also in coronary microvessels, where calcium channel blockers (CCBs) have limited efficacy. However, efficacy of exercise training for VSA remains to be elucidated. We thus aimed to examine whether vasodilator capacity of coronary microvessels is impaired in VSA patients, and if so, whether exercise exerts beneficial effects on the top of CCBs. METHODS: We performed 2 clinical protocols. In the protocol 1, we measured myocardial blood flow (MBF) using adenosine-stress dynamic computed tomography perfusion (CTP) in 38 consecutive VSA patients and 17 non-VSA controls. In the protocol 2, we conducted randomized controlled trial, where 20 VSA patients were randomly assigned to either 3-month exercise training group (Exercise group) or Non-Exercise group (n= 10 each). RESULTS: In the protocol 1, MBF on CTP was significantly decreased in the VSA group compared with the Non-VSA group (138 ± 6 vs 166 ± 10 ml/100 g/min, P = 0.02). In the protocol 2, exercise capacity was significantly increased in the Exercise group than in the Non-Exercise group (11.5 ± 0.5 to 15.4 ± 1.8 vs 12.6 ± 0.7 to 14.0 ± 0.8 ml/min/kg, P < 0.01). MBF was also significantly improved after 3 months only in the Exercise group (Exercise group, 145 ± 12 to 172 ± 8 ml/100 g/min, P < 0.04; Non-Exercise group, 143 ± 14 to 167 ± 8 ml/100 g/min, P = 0.11), although there were no significant between-group differences. CONCLUSIONS: These results provide the first evidence that, in VSA patients, exercise training on the top of CCBs treatment may be useful to improve physical performance, although its effect on MBF may be minimal.
Prognostic impacts of serum uric acid levels in patients with chronic heart failure: insights from the CHART-2 study. 国際誌

Takahide Fujihashi, Yasuhiko Sakata, Kotaro Nochioka, Masanobu Miura, Ruri Abe, Shintaro Kasahara, Masayuki Sato, Hajime Aoyanagi, Shinsuke Yamanaka, Hideka Hayashi, Takashi Shiroto, Koichiro Sugimura, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

ESC heart failure　8　(2)　1027-1038　2021年4月

DOI： 10.1002/ehf2.12765 　

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AIMS: Prognostic impacts of serum uric acid (UA) levels in patients with chronic heart failure (CHF) remain inconclusive, especially for the whole range of serum UA levels. METHODS AND RESULTS: In the Chronic Heart Failure Registry and Analysis in the Tohoku District-2 (CHART-2) study, we enrolled 4652 consecutive patients with CHF and classified them into four groups based on baseline serum UA levels by the Classification and Regression Tree: G1 (<3.8 mg/dL, N = 313), G2 (3.8-7.1 mg/dL, N = 3070), G3 (7.2-9.2 mg/dL, N = 1018), and G4 (>9.2 mg/dL, N = 251). Mean age was 71 ± 12, 69 ± 12, 68 ± 13, and 69 ± 15 years in G1, G2, G3, and G4, respectively (P < 0.001). During the median follow-up of 6.3 years, in G1, G2, G3, and G4, 111 (35%), 905 (29%), 370 (36%), and 139 (55%) patients died and 79 (25%), 729 (24%), 300 (29%), and 115 (46%) experienced heart failure hospitalization, respectively (both P < 0.001). G1 was characterized by a significantly high prevalence of women as compared with G2, G3, and G4 (59%, 32%, 24%, and 23%, respectively). Serum creatinine levels (0.8 ± 0.4, 0.9 ± 0.4, 1.2 ± 0.6, and 1.4 ± 0.8 mg/dL, respectively), prevalence of atrial fibrillation (34%, 39%, 45%, and 50%, respectively), and diuretics use (36%, 45%, 67%, and 89%, respectively) increased from G1, G2, G3 to G4 (all P < 0.001), while left ventricular ejection fraction decreased from G1, G2, G3 to G4 (59 ± 15, 58 ± 15, 54 ± 15, and 52 ± 17%, respectively, P < 0.001). Multivariable Cox proportional hazards models showed that, as compared with G2, both G1 and G4 had increased incidence of all-cause death [adjusted hazard ratio (aHR) 1.34, 95% confidence interval (CI) 1.08-1.67, P = 0.009; aHR 1.28, 95% CI 1.02-1.61, P = 0.037, respectively] and heart failure admission (aHR 1.39, 95% CI 1.09-1.78, P = 0.008 and aHR 1.35, 95% CI, 1.06-1.71, P = 0.014, respectively). This U-shaped relationship was evident in the elderly patients. Furthermore, abnormal transitions to either higher or lower levels of serum UA from G2 were associated with increased mortality (aHR 1.29, 95% CI 1.06-1.57, P = 0.012; aHR 1.57, 95% CI 1.12-2.20, P = 0.009). CONCLUSIONS: These results demonstrate that serum UA levels have the U-shaped prognostic effects and abnormal transitions to either higher or lower levels are associated with poor prognosis in the elderly patients with CHF.
Prognostic Links Between OCT-Delineated Coronary Morphologies and Coronary Functional Abnormalities in Patients With INOCA. 国際誌

Kensuke Nishimiya, Akira Suda, Kento Fukui, Kiyotaka Hao, Jun Takahashi, Yasuharu Matsumoto, Kiyoto Mitsuishi, Tasuku Watanabe, Kazuma Ohyama, Jun Sugisawa, Satoshi Tsuchiya, Koichi Satoh, Tomohiko Shindo, Shigeo Godo, Yoku Kikuchi, Takashi Shiroto, Satoshi Yasuda, Hiroaki Shimokawa

JACC. Cardiovascular interventions　14　(6)　606-618　2021年3月22日

DOI： 10.1016/j.jcin.2020.12.025 　

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OBJECTIVES: Whether there are prognostic links between coronary morphologies and coronary functional abnormalities was examined in ischemia and nonobstructive coronary artery disease (INOCA) patients. BACKGROUND: Although INOCA has attracted much attention, little is known about the prognostic impact of coronary morphologies in this disorder. METHODS: A total of 329 consecutive INOCA patients were enrolled and underwent spasm provocation testing combined with lactate sampling for diagnosis of epicardial and microvascular spasm (MVS). On the basis of the functional tests, the patients were classified into 4 groups: a control group without epicardial spasm or MVS (n = 32), MVS alone (n = 51), diffuse spasm in ≥2 coronary segments (n = 204), and focal spasm in 1 segment (n = 42). In this population, optical coherence tomography imaging of the left anterior descending coronary artery was performed for evaluation of adventitial vasa vasorum (AVV) and intraplaque neovessels (IPN). Index of microcirculatory resistance was also measured. RESULTS: MVS frequently coexisted with diffuse (70%) and focal spasm (68%) with a good correlation between AVV and index of microcirculatory resistance (R = 0.353; p = 0.022). For a median follow-up of 1,043 days, focal spasm showed the worst prognosis (log rank p = 0.005), for which IPN was a significant prognostic factor. By contrast, diffuse spasm showed the greatest AVV with an intermediate prognosis. The prognostic value of INOCA was significantly enhanced by adding AVV and IPN to the physiological indices (area under the curve = 0.88 vs. 0.76; p = 0.048). CONCLUSIONS: These results provide the first evidence that there are important prognostic links between coronary morphologies (evaluated by optical coherence tomography) and coronary functional abnormalities in patients with INOCA, indicating the importance of both evaluations in this population.
左室駆出率が保たれた若年心不全患者の臨床的特徴と転帰(Clinical Characteristics and Outcomes of Young Patients with Heart Failure with Preserved Ejection Fraction)

山中信介, 坂田泰彦, 後岡広太郎, 藤橋敬英, 林秀華, 白戸崇, 高橋潤, 宮田敏, 下川宏明, 安田聡

日本循環器学会学術集会抄録集　85回　OJ61-5　2021年3月
出版者・発行元： (一社)日本循環器学会
慢性心不全患者におけるポリファーマシーの予後的意義 CHART-2研究からの報告(Prognostic Impacts of Polypharmacy in Patients with Chronic Heart Failure: A Report from the CHART-2 Study)

藤橋敬英, 後岡広太郎, 坂田泰彦, 山中信介, 林秀華, 白戸崇, 高橋潤, 宮田敏, 下川宏明, 安田聡

日本循環器学会学術集会抄録集　85回　OJ63-5　2021年3月
出版者・発行元： (一社)日本循環器学会
Clinical Characteristics and Outcomes of Young Patients with Heart Failure with Preserved Ejection Fraction(和訳中)

山中信介, 坂田泰彦, 後岡広太郎, 藤橋敬英, 林秀華, 白戸崇, 高橋潤, 宮田敏, 下川宏明, 安田聡

日本循環器学会学術集会抄録集　85回　OJ61-5　2021年3月
出版者・発行元： (一社)日本循環器学会
Prognostic Impacts of Polypharmacy in Patients with Chronic Heart Failure: A Report from the CHART-2 Study(和訳中)

藤橋敬英, 後岡広太郎, 坂田泰彦, 山中信介, 林秀華, 白戸崇, 高橋潤, 宮田敏, 下川宏明, 安田聡

日本循環器学会学術集会抄録集　85回　OJ63-5　2021年3月
出版者・発行元： (一社)日本循環器学会
Assessment of coronary vasomotor responses to acetylcholine in German and Japanese patients with epicardial coronary spasm-more similarities than differences?

Akira Suda, Andreas Seitz, Yuji Odaka, Anastasios Athanasiadis, Giancarlo Pirozzolo, Koichi Sato, Kiyotaka Hao, Raffi Bekeredjian, Jun Takahashi, Udo Sechtem, Hiroaki Shimokawa, Peter Ong

Heart and vessels　36　(3)　337-344　2021年3月

DOI： 10.1007/s00380-020-01707-9 　

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Coronary spasm is an established cause for angina pectoris. Ethnic differences have been suggested among Asian compared to Caucasian patients regarding prevalence, gender distribution, and angiographic patterns of coronary spasm. The aim of this study was to compare contemporary German and Japanese patients with coronary spasm. Between 2011 and 2015, 149 patients with resting angina and unobstructed coronary arteries with acetylcholine-induced epicardial spasm were enrolled in Stuttgart, Germany (n = 69) and Sendai, Japan (n = 80). All patients underwent intracoronary acetylcholine testing according to a standardized protocol. Comprehensive analysis included type of spasm (focal/diffuse), dose of acetylcholine leading to spasm, and frequency of multivessel spasm. Patients in this study were 61 ± 11 years old, predominantly female (54%), and had normal left ventricular ejection fraction (73 ± 9%). Diffuse spasm was the most prevalent type of spasm (85%) whereas focal spasm was found in the remaining 15% of patients. 31% of patients had multivessel spasm. Comparing the German with the Japanese patients, distribution of spasm type (focal/diffuse, p = 0.19) and frequency of multivessel spasm (p = 0.22) were comparable. Moreover, when Japanese patients were compared with German patients and diffuse spasm with focal spasm patients, respectively, no significant differences were observed regarding the acetylcholine dose required to induce spasm (p = 0.078 and p = 0.46, respectively). In conclusion, diffuse epicardial coronary spasm is the most frequent finding among German and Japanese patients with resting angina, unobstructed coronary arteries, and epicardial spasm on acetylcholine testing. Japanese and German patients share several similarities including comparable types of spasm and frequency of multivessel spasm.
Pathophysiology and Diagnosis of Coronary Functional Abnormalities. 国際誌

Jun Takahashi, Akira Suda, Kensuke Nishimiya, Shigeo Godo, Satoshi Yasuda, Hiroaki Shimokawa

European cardiology　16　e30　2021年2月

DOI： 10.15420/ecr.2021.23 　

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Approximately one-half of patients undergoing diagnostic coronary angiography for angina have no significant coronary atherosclerotic stenosis. This clinical condition has recently been described as ischaemia with non-obstructive coronary arteries (INOCA). Coronary functional abnormalities are central to the pathogenesis of INOCA, including epicardial coronary spasm and coronary microvascular dysfunction composed of a variable combination of increased vasoconstrictive reactivity and/or reduced vasodilator function. During the last decade - in INOCA patients in particular - evidence for the prognostic impact of coronary functional abnormalities has accumulated and various non-invasive and invasive diagnostic techniques have enabled the evaluation of coronary vasomotor function in a comprehensive manner. In this review, the authors briefly summarise the recent advances in the understanding of pathophysiology and diagnosis of epicardial coronary artery spasm and coronary microvascular dysfunction.
Strategies for Percutaneous Coronary Intervention in Patients Undergoing Transcatheter Aortic Valve Implantation(和訳中)

菊地翼, 松本泰治, 土屋聡, 須田彬, 進藤智彦, 西宮健介, 神戸茂雄, 白戸崇, 高橋潤, 坂田泰彦, 下川宏明

日本心血管インターベンション治療学会抄録集　29回　1378-1378　2021年2月
出版者・発行元： (一社)日本心血管インターベンション治療学会
Role of Inflammation in Coronary Epicardial and Microvascular Dysfunction. 国際誌

Shigeo Godo, Jun Takahashi, Satoshi Yasuda, Hiroaki Shimokawa

European cardiology　16　e13　2021年2月

DOI： 10.15420/ecr.2020.47 　

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There is accumulating evidence highlighting a close relationship between inflammation and coronary microvascular dysfunction (CMD) in various experimental and clinical settings, with major clinical implications. Chronic low-grade vascular inflammation plays important roles in the underlying mechanisms behind CMD, especially in patients with coronary artery disease, obesity, heart failure with preserved ejection fraction and chronic inflammatory rheumatoid diseases. The central mechanisms of coronary vasomotion abnormalities comprise enhanced coronary vasoconstrictor reactivity, reduced endothelium-dependent and -independent coronary vasodilator capacity and increased coronary microvascular resistance, where inflammatory mediators and responses are substantially involved. How to modulate CMD to improve clinical outcomes of patients with the disorder and whether CMD management by targeting inflammatory responses can benefit patients remain challenging questions in need of further research. This review provides a concise overview of the current knowledge of the involvement of inflammation in the pathophysiology and molecular mechanisms of CMD from bench to bedside.
Prognostic Impacts of Comorbid Significant Coronary Stenosis and Coronary Artery Spasm in Patients With Stable Coronary Artery Disease. 国際誌

Kiyotaka Hao, Jun Takahashi, Yoku Kikuchi, Akira Suda, Koichi Sato, Jun Sugisawa, Satoshi Tsuchiya, Tomohiko Shindo, Kensuke Nishimiya, Shohei Ikeda, Ryuji Tsuburaya, Takashi Shiroto, Yasuharu Matsumoto, Satoshi Miyata, Yasuhiko Sakata, Satoshi Yasuda, Hiroaki Shimokawa

Journal of the American Heart Association　10　(2)　e017831　2021年1月16日

DOI： 10.1161/JAHA.120.017831 　

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BACKGROUND Stable coronary artery disease is caused by a variable combination of organic coronary stenosis and functional coronary abnormalities, such as coronary artery spasm. Thus, we examined the clinical importance of comorbid significant coronary stenosis and coronary spasm. METHODS AND RESULTS We enrolled 236 consecutive patients with suspected angina who underwent acetylcholine provocation testing for coronary spasm and fractional flow reserve (FFR) measurement. Among them, 175 patients were diagnosed as having vasospastic angina (VSA), whereas the remaining 61 had no VSA (non-VSA group). The patients with VSA were further divided into the following 3 groups based on angiography and FFR: no organic stenosis (≤50% luminal stenosis; VSA-alone group, n=110), insignificant stenosis of FFR>0.80 (high-FFR group, n=36), and significant stenosis of FFR≤0.80 (low-FFR group, n=29). The incidence of major adverse cardiovascular events, including cardiovascular death, nonfatal myocardial infarction, urgent percutaneous coronary intervention, and hospitalization attributed to unstable angina was evaluated. All patients with VSA received calcium channel blockers, and 28 patients (95%) in the low-FFR group underwent a planned percutaneous coronary intervention. During a median follow-up period of 656 days, although the incidence of major adverse cardiovascular events was low and comparable among non-VSA, VSA-alone, and high-FFR groups, the low-FFR group had an extremely poor prognosis (non-VSA group, 1.6%; VSA-alone group, 3.6%; high-FFR group, 5.6%; low-FFR group, 27.6%) (P<0.001). Importantly, all 8 patients with major adverse cardiovascular events in the low-FFR group were appropriately treated with percutaneous coronary intervention and calcium channel blockers. CONCLUSIONS These results indicate that patients with VSA with significant coronary stenosis represent a high-risk population despite current guideline-recommended therapies, suggesting the importance of routine coronary functional testing in this population.
Role of inflammation in coronary epicardial and microvascular dysfunction

Shigeo Godo, Jun Takahashi, Satoshi Yasuda, Hiroaki Shimokawa

European Cardiology Review　16　2021年
出版者・発行元： Radcliffe Medical Media
DOI： 10.15420/ECR.2020.47 　

ISSN：1758-3764 1758-3756
Low-intensity pulsed ultrasound therapy suppresses coronary adventitial inflammatory changes and hyperconstricting responses after coronary stent implantation in pigs in vivo. 国際誌

Tasuku Watanabe, Yasuharu Matsumoto, Kensuke Nishimiya, Tomohiko Shindo, Hirokazu Amamizu, Jun Sugisawa, Satoshi Tsuchiya, Koichi Sato, Susumu Morosawa, Kazuma Ohyama, Tomomi Watanabe-Asaka, Moyuru Hayashi, Yoshiko Kawai, Jun Takahashi, Satoshi Yasuda, Hiroaki Shimokawa

PloS one　16　(9)　e0257175　2021年

DOI： 10.1371/journal.pone.0257175 　

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BACKGROUNDS: We demonstrated that coronary adventitial inflammation plays important roles in the pathogenesis of drug-eluting stent (DES)-induced coronary hyperconstricting responses in pigs in vivo. However, no therapy is yet available to treat coronary adventitial inflammation. We thus developed the low-intensity pulsed ultrasound (LIPUS) therapy that ameliorates myocardial ischemia by enhancing angiogenesis. AIMS: We aimed to examine whether our LIPUS therapy suppresses DES-induced coronary hyperconstricting responses in pigs in vivo, and if so, what mechanisms are involved. METHODS: Sixteen normal male pigs were randomly assigned to the LIPUS or the sham therapy groups after DES implantation into the left anterior descending (LAD) coronary artery. In the LIPUS group, LIPUS (32 cycles, 193 mW/cm2) was applied to the heart at 3 different levels (segments proximal and distal to the stent edges and middle of the stent) for 20 min at each level for every other day for 2 weeks. The sham therapy group was treated in the same manner but without LIPUS. At 4 weeks after stent implantation, we performed coronary angiography, followed by immunohistological analysis. RESULTS: Coronary vasoconstricting responses to serotonin in LAD at DES edges were significantly suppressed in the LIPUS group compared with the sham group. Furthermore, lymph transport speed in vivo was significantly faster in the LIPUS group than in the sham group. Histological analysis at DES edges showed that inflammatory changes and Rho-kinase activity were significantly suppressed in the LIPUS group, associated with eNOS up-regulation and enhanced lymph-angiogenesis. CONCLUSIONS: These results suggest that our non-invasive LIPUS therapy is useful to treat coronary functional abnormalities caused by coronary adventitial inflammation, indicating its potential for the novel and safe therapeutic approach of coronary artery disease.
International prospective cohort study of microvascular angina - Rationale and design. 国際誌

Akira Suda, Jun Takahashi, John F Beltrame, Colin Berry, Paolo G Camici, Filippo Crea, Javier Escaned, Tom Ford, Juan Carlos Kaski, Takahiko Kiyooka, Puja K Metha, Peter Ong, Yukio Ozaki, Carl Pepine, Ornella Rimoldi, Basmah Safdar, Udo Sechtem, Kenichi Tsujita, Eric Yii, C Noel Bairey Merz, Hiroaki Shimokawa

International journal of cardiology. Heart & vasculature　31　100630-100630　2020年12月

DOI： 10.1016/j.ijcha.2020.100630 　

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Background: Patients with signs and symptoms of myocardial ischemia and non-obstructive coronary artery disease (CAD) frequently have coronary functional abnormalities, including coronary microvascular dysfunction. Those with the latter are grouped under the term "microvascular angina" (MVA). Although diagnostic criteria exist for MVA, as recently proposed by our COVADIS (COronary VAsomotor Disorders International Study) group and the condition has been increasingly recognized in clinical practice, the clinical characteristics and long-term prognosis of MVA patients in the current era remain to be fully elucidated. Aims: In the present study, we aimed to prospectively assess the clinical characteristics and long-term prognosis of MVA subjects in the current era in an international, multicenter, observational, and prospective registry study. Methods: A total of 15 medical centers across 7 countries (USA, UK, Germany, Spain, Italy, Australia, and Japan) enrolled subjects fulfilling the COVADIS diagnostic criteria for MVA as follows; (1) signs and/or symptoms of myocardial ischemia, (2) absence of obstructive CAD, and (3) objective evidence of myocardial ischemia and/or coronary microvascular dysfunction. The primary endpoint was the composite of major cardiovascular events (MACE), including cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, hospitalization due to heart failure or unstable angina. Between July 2015 and December 2018, a total of 706 subjects with MVA (M/F 256/450, 61.1 ± 11.8 [SD] yrs.) were registered. Subjects will be followed for at least 1 year. Summary: The present study will provide important information regarding the clinical characteristics, management, and long-term prognosis of MVA patients in the current era.
Prognostic impacts of dynamic cardiac structural changes in heart failure patients with preserved left ventricular ejection fraction. 国際誌査読有り

Shinsuke Yamanaka, Yasuhiko Sakata, Kotaro Nochioka, Masanobu Miura, Shintaro Kasahara, Masayuki Sato, Hajime Aoyanagi, Takahide Fujihashi, Hideka Hayashi, Takashi Shiroto, Koichiro Sugimura, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

European journal of heart failure　22　(12)　2258-2268　2020年12月

DOI： 10.1002/ejhf.1945 　

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AIMS: We aimed to examine temporal changes in left ventricular (LV) structures and their prognostic impacts in patients with heart failure (HF) and preserved ejection fraction (HFpEF). METHODS AND RESULTS: In the Chronic Heart Failure Analysis and Registry in the Tohoku District-2 (CHART-2) study (n = 10 219), we divided 2698 consecutive HFpEF patients (68.9 ± 12.2 years, 32.1% female) into three groups by LV hypertrophy (LVH) and enlargement (LVE) at baseline: (-)LVH/(-)LVE (n = 989), (+)LVH/(-)LVE (n = 1448), and (+)LVH/(+)LVE (n = 261). We examined temporal changes in LV structures and their prognostic impacts during a median 8.7-year follow-up. From (-)LVH/(-)LVE, (+)LVH/(-)LVE to (+)LVH/(+)LVE at baseline, the incidence of the primary outcome, a composite of cardiovascular death or HF admission, significantly increased. Among 1808 patients who underwent echocardiography at both baseline and 1 year, we noted substantial group transitions from baseline to 1 year; the transition rates from (-)LVH/(-)LVE to (+)LVH/(-)LVE, from (+)LVH/(-)LVE to (-)LVH/(-)LVE, from (+)LVH/(-)LVE to (+)LVH/(+)LVE, and from (+)LVH/(+)LVE to (+)LVH/(-)LVE were 27% (182/671), 22% (213/967), 6% (59/967), and 26% (44/170), respectively. In the univariable Cox proportional hazard model, patients who transitioned from (+)LVH/(-)LVE to (+)LVH/(+)LVE or remained in (+)LVH/(+)LVE had the worst subsequent prognosis [hazard ratio (HR) 4.65, 95% confidence interval (CI) 3.09-6.99, P < 0.001; HR 4.01, 95% CI 2.85-5.65, P < 0.001, respectively], as compared with those who remained in (-)LVH/(-)LVE. These results were unchanged after adjustment for the covariates including baseline LV ejection fraction (LVEF) and 1-year LVEF change. CONCLUSION: In HFpEF patients, LV structures dynamically change over time with significant prognostic impacts, where patients who develop LVE with LVH have the worst prognosis.
自己拡張型弁を留置された冠動脈疾患に対する経皮的冠動脈インターベンション

菊地翼, 松本泰治, 土屋聡, 進藤智彦, 神戸茂雄, 四宮健介, 白戸崇, 高橋潤, 下川宏明

脈管学　60　(Suppl.)　S131-S131　2020年10月
出版者・発行元： (一社)日本脈管学会
ISSN：0387-1126

eISSN：1880-8840
音波を用いた低侵襲治療の開発

進藤智彦, 高橋潤, 白戸崇, 菊地翼, 西宮健介, 神戸茂雄, 一條貞満, 中田貴史, 坂田泰彦, 金井浩, 安田聡, 下川宏明

脈管学　60　(Suppl.)　S85-S85　2020年10月
出版者・発行元： (一社)日本脈管学会
ISSN：0387-1126

eISSN：1880-8840
血管内イメージングの展望-Future 血管内OCTの最新知見と今後の展望

西宮健介, 松本泰治, 高橋潤, Tearney Guillermo, 下川宏明

脈管学　60　(Suppl.)　S90-S90　2020年10月
出版者・発行元： (一社)日本脈管学会
ISSN：0387-1126

eISSN：1880-8840
脈管機能異常の最前線非閉塞性冠動脈疾患患者における冠動脈機能異常の包括的評価

須田彬, 高橋潤, 菊地翼, 西宮健介, 進藤智彦, 神戸茂雄, 白戸崇, 渡辺翼, 福井健人, 坂田泰彦, 安田聡, 下川宏明

脈管学　60　(Suppl.)　S99-S99　2020年10月
出版者・発行元： (一社)日本脈管学会
ISSN：0387-1126

eISSN：1880-8840
生体吸収性ポリマーによる薬剤溶出性ステント留置後冠動脈過収縮反応の抑制効果光干渉断層撮影法(OCT)を用いた臨床的検討

光石清人, 西宮健介, 松本泰治, 渡辺翼, 土屋聡, 杉澤潤, 佐藤公一, 須田彬, 進藤智彦, 神戸茂雄, 池田尚平, 羽尾清貴, 菊地翼, 高橋潤, 下川宏明

脈管学　60　(Suppl.)　S127-S127　2020年10月
出版者・発行元： (一社)日本脈管学会
ISSN：0387-1126

eISSN：1880-8840
冠動脈閉塞を伴わない心筋梗塞(MINOCA)患者に関する検討宮城県AMI登録研究

羽尾清貴, 高橋潤, 佐藤公一, 須田彬, 進藤智彦, 神戸茂雄, 西宮健介, 菊地翼, 白戸崇, 坂田泰彦, 下川宏明

脈管学　60　(Suppl.)　S128-S128　2020年10月
出版者・発行元： (一社)日本脈管学会
ISSN：0387-1126

eISSN：1880-8840
非閉塞性冠動脈疾患患者における冠動脈機能異常の性差についての検討

須田彬, 高橋潤, 菊地翼, 進藤智彦, 神戸茂雄, 西宮健介, 渡辺翼, 白戸崇, 坂田泰彦, 下田宏明

脈管学　60　(Suppl.)　S128-S128　2020年10月
出版者・発行元： (一社)日本脈管学会
ISSN：0387-1126

eISSN：1880-8840
補助循環用ポンプカテーテルIMPELLAの使用経験と展望

神戸茂雄, 菊地翼, 高橋潤, 進藤智彦, 西宮健介, 白戸崇, 坂田泰彦, 齋木佳克, 下川宏明

脈管学　60　(Suppl.)　S130-S130　2020年10月
出版者・発行元： (一社)日本脈管学会
ISSN：0387-1126

eISSN：1880-8840
In-hospital morality associated with acute myocardial infarction was inversely related with the number of coronary risk factors in patients from a Japanese nation-wide real-world database. 国際誌

Hiroyoshi Mori, Hiroshi Suzuki, Kensaku Nishihira, Satoshi Honda, Sunao Kojima, Misa Takegami, Jun Takahashi, Tomonori Itoh, Tetsu Watanabe, Takashi Takenaka, Masaaki Ito, Morimasa Takayama, Kazuomi Kario, Tetsuya Sumiyoshi, Kazuo Kimura, Satoshi Yasuda

International Journal of Cardiology. Hypertension　6　100039-100039　2020年9月

DOI： 10.1016/j.ijchy.2020.100039 　

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Background: Hypertension, diabetes, dyslipidemia and smoking are established coronary risk factors for coronary heart disease in the general population. However, in Japanese patients with acute myocardial infarction (AMI), the impact of the number of coronary risk factors on in-hospital morality remains unclear. Methods: The Japan Acute Myocardial Infarction Registry (JAMIR) is a nationwide real-world database. We examined the association between the number of coronary risk factors and in-hospital mortality. Results: Data were obtained from total of 20462 AMI patients (mean age, 68.8 ± 13.3 years old; 15281 men, 5181 women). The prevalence of hypertension increased with advancing age, while the prevalence of smoking decreased with advancing age. The prevalence of diabetes and dyslipidemia were highest in middle age. A majority (76.9%) of the patients with AMI had at least 1 of these coronary risk factors. Overall, the number of coronary risk factor was relatively less in older subjects and women under 50 years old. Crude in-hospital mortality rates were 10.7%, 10.5%, 7.2%, 5.0% and 4.5% with 0, 1, 2, 3 and 4 risk factors, respectively. After adjusting for age and sex, there was an inverse association between the number of coronary risk factors and the in-hospital mortality (adjusted odds ratio [1.68; 95% confidence interval, 1.20-2.35] among individuals with 0 vs. 4 risk factors). Conclusion: In the present study of Japanese patients with AMI, who received modern medical treatment, in-hospital mortality was inversely related to the number of coronary risk factors. To investigate the underlying reasons for these findings, further studies are needed.
A case of recurrent takotsubo-like cardiomyopathy associated with pheochromocytoma exhibiting different patterns of left ventricular wall motion abnormality and coronary vasospasm: a case report. 国際誌

Koichi Sato, Jun Takahashi, Keiko Amano, Hiroaki Shimokawa

European heart journal. Case reports　4　(4)　1-5　2020年8月

DOI： 10.1093/ehjcr/ytaa138 　

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Background: Takotsubo-like cardiomyopathy associated with pheochromocytoma (Pheo-TTS) is a recognized but uncommon disorder. While Pheo-TTS might more often recur and the pattern of left ventricular (LV) wall motion abnormality is more diverse compared with primary TTS, it remains to be elucidated whether coronary functional abnormalities are also involved. Case summary: A 50-year-old woman was referred with a chief complaint of transient chest pain, dyspnoea, and paroxysmal thyroid swelling that usually developed after meals. In the past, she had been admitted to emergency rooms three times due to pulmonary oedema following the above attacks. Serial cardiac catheterizations showed normal coronary arteries and morphologically different types of LV dysfunction each time; apical LV ballooning at the first, basal LV ballooning at the second, and diffuse LV hypokinesis at the last admission. Acetylcholine (ACh) provocation testing for coronary vasospasm was negative at the second admission. During hospitalization in our department, abdominal ultrasonography for screening detected a right adrenal mass and the urinary normetanephrine level was increased. The adrenal tumour was urgently removed surgically and finally she was diagnosed as having norepinephrine-secreting pheochromocytoma. Acetylcholine testing was again performed just after the operation, showing both epicardial and microvascular coronary spasms. Since the operation, she has been free of symptoms. Importantly, ACh testing at 1-year follow-up showed that epicardial spasm was no longer noted, whereas coronary microvascular spasm persisted. Discussion: Adrenal pheochromocytoma could cause recurrent attacks of catecholamine surges with different patterns of LV dysfunction, where coronary vasospasm may also be involved along the coronary arteries.
The impact of antiplatelet therapy on patients with vasospastic angina: A multicenter registry study of the Japanese Coronary Spasm Association. 国際誌査読有り

Hiroyoshi Mori, Jun Takahashi, Koichi Sato, Satoshi Miyata, Yusuke Takagi, Ryusuke Tsunoda, Tetsuya Sumiyoshi, Motoyuki Matsui, Yasuhiko Tanabe, Shozo Sueda, Shinichi Momomura, Koichi Kaikita, Satoshi Yasuda, Hisao Ogawa, Hiroaki Shimokawa, Hiroshi Suzuki

International journal of cardiology. Heart & vasculature　29　100561-100561　2020年8月

DOI： 10.1016/j.ijcha.2020.100561 　

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Background: Antiplatelet therapy (APT) is generally used in patients with coronary artery disease. However, for patients with vasospastic angina (VSA), the impact of APT is not fully understood. Methods: In a multicenter registry study of the Japanese Coronary Spasm Association (n = 1429), patients with or without APT were compared. The primary endpoint was major adverse cardiac events (MACEs), defined as cardiac death, non-fatal myocardial infarction, unstable angina, heart failure and appropriate ICD (Implantable cardioverter defibrillator) shock. Propensity score matching and a multivariable cox proportional hazard model were used to adjust for selection bias for treatment and potential confounding factors. Results: In the whole population, 669 patients received APT, while 760 patients did not receive APT. Patients with APT had a greater prevalence of comorbidities, such as hypertension, diabetes, dyslipidemia and smoking, than those without APT. The prevalences of previous myocardial infarction, spontaneous ST changes, significant organic stenosis and medications including calcium channel blocker, nitrate, statin and angiotensin-converting enzyme inhibitor/angiotensin receptor blocker were greater in patients with APT than those without APT. After propensity matching (n = 335 for both groups), during the median follow-up period of 32 months, the incidence rate of MACE was comparable between the patients with and without APT (P = 0.24). MACEs occurred in 5.7% of patients with APT and in 3.6% of those without APT (P = 0.20). All-cause death occurred in 0.6% of patients with APT and 1.8% of those without APT (p = 0.16). Conclusion: In this multicenter registry study, anti-platelet therapy exerted no beneficial effects for VSA patients.
ステージBとステージC/D心不全における心臓突然死の発生率と予測因子 CHART-2 Studyからの洞察(Incidence and Predictors of Sudden Cardiac Death in Stage B vs. Stage C/D Heart Failure: Insights from the CHART-2 Study)

林秀華, 坂田泰彦, 後岡広太郎, 青柳肇, 山中信介, 藤橋敬英, 白戸崇, 杉村宏一郎, 高橋潤, 宮田敏, 下川宏明

日本循環器学会学術集会抄録集　84回　PJ31-6　2020年7月
出版者・発行元： (一社)日本循環器学会
ステージBとステージC/D心不全における心臓突然死の発生率と予測因子 CHART-2 Studyからの洞察(Incidence and Predictors of Sudden Cardiac Death in Stage B vs. Stage C/D Heart Failure: Insights from the CHART-2 Study)

林秀華, 坂田泰彦, 後岡広太郎, 青柳肇, 山中信介, 藤橋敬英, 白戸崇, 杉村宏一郎, 高橋潤, 宮田敏, 下川宏明

日本循環器学会学術集会抄録集　84回　PJ31-6　2020年7月
出版者・発行元： (一社)日本循環器学会
TAVIは重症大動脈弁狭窄症患者のBNP値の低下に伴う冠微小血管の拡張機能障害を改善する(TAVI Improves Impaired Vasodilator Capacity of Coronary Microvessels Associated with Decreased BNP Levels in Patients with Severe Aortic Stenosis)

土屋聡, 松本泰治, 杉澤潤, 佐藤公一, 須田彬, 進藤智彦, 神戸茂雄, 西宮健介, 竹内雅史, 菊地翼, 羽尾清貴, 高橋潤, 熊谷紀一郎, 齋木佳克, 下川宏明

日本循環器学会学術集会抄録集　84回　PJ18-8　2020年7月
出版者・発行元： (一社)日本循環器学会
Difference in the in-hospital prognosis between ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction with high Killip class: Data from the Japan Acute Myocardial Infarction Registry. 国際誌

Motoki Fukutomi, Kensaku Nishihira, Satoshi Honda, Sunao Kojima, Misa Takegami, Jun Takahashi, Tomonori Itoh, Tetsu Watanabe, Takashi Takenaka, Masaaki Ito, Morimasa Takayama, Kazuomi Kario, Tetsuya Sumiyoshi, Kazuo Kimura, Satoshi Yasuda

European heart journal. Acute cardiovascular care　2048872620926681-2048872620926681　2020年5月18日

DOI： 10.1177/2048872620926681 　

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BACKGROUND: ST-segment elevation myocardial infarction is known to be associated with worse short-term outcome than non-ST-segment elevation myocardial infarction. However, whether or not this trend holds true in patients with a high Killip class has been unclear. METHODS: We analyzed 3704 acute myocardial infarction patients with Killip II-IV class from the Japan Acute Myocardial Infarction Registry and compared the short-term outcomes between ST-segment elevation myocardial infarction (n = 2943) and non-ST-segment elevation myocardial infarction (n = 761). In addition, we also performed the same analysis in different age subgroups: <80 years and ≥80 years. RESULTS: In the overall population, there were no significant difference in the in-hospital mortality (20.0% vs 17.1%, p = 0.065) between ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction groups. Patients <80 years of age also showed no difference in the in-hospital mortality (15.7% vs 15.2%, p = 0.807) between ST-segment elevation myocardial infarction (n = 2001) and non-ST-segment elevation myocardial infarction (n = 453) groups, whereas among those ≥80 years of age, ST-segment elevation myocardial infarction (n = 942) was associated with significantly higher in-hospital mortality (29.3% vs 19.8%, p = 0.001) and in-hospital cardiac mortality (23.3% vs 15.0%, p = 0.002) than non-ST-segment elevation myocardial infarction (n = 308). After adjusting for covariates, ST-segment elevation myocardial infarction was a significant predictor for in-hospital mortality (odds ratio 2.117; 95% confidence interval, 1.204-3.722; p = 0.009) in patients ≥80 years of age. CONCLUSION: Among cases of acute myocardial infarction with a high Killip class, there was no marked difference in the short-term outcomes between ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction in younger patients, while ST-segment elevation myocardial infarction showed worse short-term outcomes in elderly patients than non-ST-segment elevation myocardial infarction. Future study identifying the prognostic factors for the specific anticipation intensive cares is needed in this high-risk group.
Difference in the in-hospital prognosis between ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction with high Killip class: Data from the Japan Acute Myocardial Infarction Registry. 国際誌

Motoki Fukutomi, Kensaku Nishihira, Satoshi Honda, Sunao Kojima, Misa Takegami, Jun Takahashi, Tomonori Itoh, Tetsu Watanabe, Takashi Takenaka, Masaaki Ito, Morimasa Takayama, Kazuomi Kario, Tetsuya Sumiyoshi, Kazuo Kimura, Satoshi Yasuda

European heart journal. Acute cardiovascular care　2020年5月18日

DOI： 10.1177/2048872620926681 　

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BACKGROUND: ST-segment elevation myocardial infarction is known to be associated with worse short-term outcome than non-ST-segment elevation myocardial infarction. However, whether or not this trend holds true in patients with a high Killip class has been unclear. METHODS: We analyzed 3704 acute myocardial infarction patients with Killip II-IV class from the Japan Acute Myocardial Infarction Registry and compared the short-term outcomes between ST-segment elevation myocardial infarction (n = 2943) and non-ST-segment elevation myocardial infarction (n = 761). In addition, we also performed the same analysis in different age subgroups: <80 years and ≥80 years. RESULTS: In the overall population, there were no significant difference in the in-hospital mortality (20.0% vs 17.1%, p = 0.065) between ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction groups. Patients <80 years of age also showed no difference in the in-hospital mortality (15.7% vs 15.2%, p = 0.807) between ST-segment elevation myocardial infarction (n = 2001) and non-ST-segment elevation myocardial infarction (n = 453) groups, whereas among those ≥80 years of age, ST-segment elevation myocardial infarction (n = 942) was associated with significantly higher in-hospital mortality (29.3% vs 19.8%, p = 0.001) and in-hospital cardiac mortality (23.3% vs 15.0%, p = 0.002) than non-ST-segment elevation myocardial infarction (n = 308). After adjusting for covariates, ST-segment elevation myocardial infarction was a significant predictor for in-hospital mortality (odds ratio 2.117; 95% confidence interval, 1.204-3.722; p = 0.009) in patients ≥80 years of age. CONCLUSION: Among cases of acute myocardial infarction with a high Killip class, there was no marked difference in the short-term outcomes between ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction in younger patients, while ST-segment elevation myocardial infarction showed worse short-term outcomes in elderly patients than non-ST-segment elevation myocardial infarction. Future study identifying the prognostic factors for the specific anticipation intensive cares is needed in this high-risk group.
Marked Impairment of Endothelium-Dependent Digital Vasodilatations in Patients With Microvascular Angina: Evidence for Systemic Small Artery Disease. 国際誌査読有り

Shoko Ohura-Kajitani, Takashi Shiroto, Shigeo Godo, Yosuke Ikumi, Akiyo Ito, Shuhei Tanaka, Koichi Sato, Jun Sugisawa, Satoshi Tsuchiya, Akira Suda, Tomohiko Shindo, Shohei Ikeda, Kiyotaka Hao, Yoku Kikuchi, Kotaro Nochioka, Yasuharu Matsumoto, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

Arteriosclerosis, thrombosis, and vascular biology　ATVBAHA119313704　2020年4月2日

DOI： 10.1161/ATVBAHA.119.313704 　

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OBJECTIVE: It remains to be elucidated whether and how endothelial functions are impaired in peripheral circulation of patients with coronary functional disorders, such as vasospastic angina (VSA) and microvascular angina (MVA). We simultaneously examined endothelial functions of peripheral conduit and resistance arteries in patients with coronary functional disorders, with a special reference to NO and endothelium-dependent hyperpolarization factors. Approach and Results: Based on the results of invasive coronary acetylcholine testing and coronary physiological measurements, we divided 43 patients into 3 groups; VSA, MVA, and VSA+MVA. Endothelium-dependent vasodilatations of the brachial artery and fingertip arterioles to intra-arterial infusion of bradykinin were simultaneously evaluated by ultrasonography and peripheral arterial tonometry, respectively. To assess NO and endothelium-dependent hyperpolarization factors, measurements were repeated after oral aspirin and intra-arterial infusion of NG-monomethyl-L-arginine. Additionally, endothelium-independent vasodilatations to sublingual nitroglycerin and plasma levels of biomarkers for endothelial functions were measured. Surprisingly, digital vasodilatations to bradykinin were almost absent in patients with MVA alone and those with VSA+MVA compared with those with VSA alone. Mechanistically, both NO- and endothelium-dependent hyperpolarization-mediated digital vasodilatations were markedly impaired in patients with MVA alone. In contrast, endothelium-independent vasodilatations to nitroglycerin were comparable among the 3 groups. Plasma levels of soluble VCAM (vascular cell adhesion molecule)-1 were significantly higher in patients with MVA alone compared with those with VSA alone. CONCLUSIONS: These results provide the first evidence that both NO- and endothelium-dependent hyperpolarization-mediated digital vasodilatations are markedly impaired in MVA patients, suggesting that MVA is a cardiac manifestation of the systemic small artery disease.
Clinical characteristics and prognostic factors in elderly patients with chronic heart failure -A report from the CHART-2 study. 国際誌査読有り

Masayuki Sato, Yasuhiko Sakata, Kenjiro Sato, Kotaro Nochioka, Masanobu Miura, Ruri Abe, Takuya Oikawa, Shintaro Kasahara, Hajime Aoyanagi, Shinsuke Yamanaka, Takahide Fujihashi, Hideka Hayashi, Takashi Shiroto, Koichiro Sugimura, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

International journal of cardiology. Heart & vasculature　27　100497-100497　2020年4月

DOI： 10.1016/j.ijcha.2020.100497 　

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Background: Since most of the randomized clinical trials for heart failure (HF) were designed to exclude elderly patients, limited data are available on their clinical characteristics, prognosis, and prognostic factors. Methods: We compared clinical characteristics, prognosis, and prognostic factors among Stage C/D HF patients in our CHART-2 Study (N = 4876, mean 69 years, women 32%, 6.3-year follow-up) by age (G1, ≤64 years, N = 1521; G2, 65-74 years, N = 1510; and G3, ≥75 years, N = 1845). Results: From G1 to G3, the prevalence of women, left ventricular ejection fraction (LVEF) and plasma levels of B-type natriuretic peptide (BNP) increased (all P < 0.001). Similarly, 5-year mortality increased (9.9, 17.3 to 39.9%, P < 0.001) along with a decrease in proportion of cardiovascular death and an increase in non-cardiovascular death in both sexes. While all-cause and cardiovascular mortality was comparable between the sexes, women had significantly lower incidence of non-cardiovascular death than men in G2 and G3, which was attributable to the higher incidence of cancer death and pneumonia death in men than in women. Although NYHA functional class III-IV, chronic kidney disease, cancer, LVEF, and BNP had significant impacts on all-cause death in all groups, their impacts were less evident in G3 as compared with G1. Conclusions: The elderly HF patients, as compared with younger HF patients, were characterized by more severe clinical background, increased proportion of non-cardiovascular death and worse prognosis with different impacts of prognostic factors across the age groups.
Temporal changes in left ventricular ejection fraction and their prognostic impacts in patients with Stage B heart failure. 国際誌査読有り

Hajime Aoyanagi, Kotaro Nochioka, Yasuhiko Sakata, Masanobu Miura, Takashi Shiroto, Ruri Abe, Shintaro Kasahara, Masayuki Sato, Takahide Fujihashi, Shinsuke Yamanaka, Hideka Hayashi, Koichiro Sugimura, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

International journal of cardiology　2020年2月15日

DOI： 10.1016/j.ijcard.2020.02.040 　

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BACKGROUND: We have recently demonstrated that left ventricular ejection fraction (LVEF) dynamically changes over time with prognostic impacts in Stage C/D patients, namely, those who have a current or past history of heart failure (HF). However, it is unknown whether this is also the case in asymptomatic Stage B patients, namely, those who have a risk of HF, but do not have a history of HF. METHODS: In our CHART-2 Study (N = 10,219), we enrolled 4005 Stage B patients and divided them into 3 groups by LVEF; preserved EF (pEF, LVEF ≥50%, N = 3526), mid-range EF (mrEF, LVEF 41-49%, N = 302), and reduced EF (rEF, LVEF ≤40%, N = 177). We examined the prognostic impacts of LVEF transitions among the 3 groups in comparison with 4477 patients with Stage C/D HF. RESULTS: Stage B were characterized by less severe clinical status and better prognosis compared with Stage C/D. Stage B in mrEF and rEF at baseline dynamically transitioned to other groups at 1-year, whereas those in pEF unchanged; at 1-year, mrEF transitioned to pEF/rEF by 50/16%, and rEF transitioned to pEF/mrEF by 25/31%, respectively, whereas pEF transitioned to mrEF/rEF by only 3.6/0.7%, respectively, which were consistent with findings in findings with Stage C/D. Although LVEF decrease was directly associated with all-cause mortality in both the Stage B and Stage C/D with pEF, factors related to LVEF changes were different between the 2 groups. CONCLUSIONS: In Stage B, LVEF dynamically changes with prognostic impacts as in Stage C/D, whereas different determination factors may be involved in the 2 stages. CLINICAL TRIAL REGISTRATION: Chronic Heart Failure Analysis and Registry in the Tohoku District (CHART)-2 (NCT00418041).
Risk of de-novo heart failure and competing risk in asymptomatic patients with structural heart diseases. 国際誌査読有り

Tsuyoshi Takada, Yasuhiko Sakata, Kotaro Nochioka, Masanobu Miura, Ruri Abe, Shintaro Kasahara, Masayuki Sato, Hajime Aoyanagi, Takahide Fujihashi, Shinsuke Yamanaka, Kota Suzuki, Takashi Shiroto, Koichiro Sugimura, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

International journal of cardiology　2020年2月6日

DOI： 10.1016/j.ijcard.2020.02.015 　

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AIMS: Asymptomatic patients with structural heart diseases are classified as a population at high risk for heart failure (HF) in Stage B. However, limited data are available regarding incidence and related factors of de-novo HF (DNHF) considering competing risk in this population. METHODS AND RESULTS: In 3362 Stage B patients (mean age 68 yrs, male 76%) from the CHART-2 Study (N = 10,219), we examined incidence of death and DNHF, defined as the first episode of either HF hospitalization or HF death, and factors related to DNHF. RESULTS: During the median 6.0-year follow-up, 627 deaths (31/1000 person-years) and 293 DNHF (15/1000 person-years) occurred. Among the 627 deaths, 212 (34%) and 325 (52%) were specified as cardiovascular and non-cardiovascular deaths, respectively. During the follow-up of 271 DNHF hospitalizations, we observed 124 deaths, including 65 (52%) cardiovascular and 47 (40%) non-cardiovascular deaths. The competing risk model showed that age, diabetes mellitus, stroke, atrial fibrillation, diastolic blood pressure, hemoglobin levels, estimated glomerular filtration ratio and left ventricular ejection fraction was significantly associated with DNHF. Bayesian structural equation modeling showed that many of these cardiac and non-cardiac variables contribute to DNHF by affecting each other, while diabetes mellitus was independently associated with DNHF. CONCLUSIONS: Stage B patients had a high incidence of DNHF as well as that of death due to both cardiovascular and non-cardiovascular causes. Thus, management of Stage B patients should include multidisciplinary approaches considering both cardiac and non-cardiac factors, in order to prevent DNHF as well as non-HF death as a competing risk. TRIAL REGISTRATION: clinicaltrials.gov identifier: NCT00418041.
Transcatheter aortic valve implantation improves cognitive function associated with increased cerebral blood flow in elderly patients with severe aortic stenosis. 国際誌査読有り

Satoshi Tsuchiya, Yasuharu Matsumoto, Hideaki Suzuki, Kentaro Takanami, Yoku Kikuchi, Jun Takahashi, Satoshi Miyata, Naoki Tomita, Kiichiro Kumagai, Yasuyuki Taki, Yoshikatsu Saiki, Hiroyuki Arai, Hiroaki Shimokawa

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology　2020年1月21日

DOI： 10.4244/EIJ-D-19-00489 　

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AIMS: The aim of this study was to examine the mechanisms of cognitive impairment and reversibility in elderly patients with severe aortic stenosis (AS) after transcatheter aortic valve implantation (TAVI) with a special reference to cerebral blood flow (CBF). METHODS AND RESULTS: We examined 15 elderly patients with severe AS (mean age 83.2±4.5 years, 12 female) who underwent TAVI. Before and 3 months after TAVI, we evaluated cognitive function with the Logical Memory II (LM II), cardiac output (CO) with echocardiography, and CBF with 99mTc single-photon emission computed tomography (SPECT). LM II score and CO were significantly increased after TAVI compared with baseline (P<0.01 for LM II, P<0.005 for CO). Notably, CBF in the local regions, including that in the right hippocampus, was significantly increased after TAVI (P<0.005 at each voxel). The patients with increased CO after TAVI also showed significantly increased CBF in the right hippocampus compared with those without it (P<0.01). Importantly, CBF in the right hippocampus were positively correlated with LM II scores (P<0.05). CONCLUSIONS: These results provide the first evidence that TAVI may improve cognitive functions associated with increased cerebral perfusion especially in the hippocampus in elderly patients with severe AS.
Clinical benefits and risks of antithrombotic therapy in patients with atrial fibrillation with comorbidities - A report from the CHART-2 Study. 国際誌査読有り

Takashi Shiroto, Yasuhiko Sakata, Kotaro Nochioka, Ruri Abe, Shintaro Kasahara, Masayuki Sato, Hajime Aoyanagi, Takahide Fujihashi, Shinsuke Yamanaka, Hideka Hayashi, Masanobu Miura, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

International journal of cardiology　299　160-168　2020年1月15日

DOI： 10.1016/j.ijcard.2019.09.022 　

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BACKGROUND: The benefits of antithrombotic therapy (ATT) for atrial fibrillation (AF) are occasionally offset by major bleeding complications. However, the clinical benefits and risks of ATT in AF patients, with special references to comorbidities, such as heart failure (HF), coronary artery disease (CAD), and the patterns of AF, remain to be fully elucidated. METHODS: A total of 3221 consecutive AF patients from our Chronic Heart Failure Analysis and Registry in the Tohoku District-2 (CHART-2) Study (N = 10,219) were divided into 4 groups based on ATT at enrollment; no-ATT, anticoagulant alone, antiplatelet alone, and both of them (AC&AP). Then, efficacy and safety outcomes including thromboembolic events, major bleeding, and mortality were evaluated among the 4 groups. RESULTS: Anticoagulant monotherapy was associated with reduced risk of ischemic stroke in patients with but not in those without HF, CAD, or non-paroxysmal AF. Although there was no significant difference in major bleeding among the 4 groups, a composite of thromboembolism and major bleeding occurred more frequently in the AC&AP group, even in combination with anticoagulants and single antiplatelet therapy, indicating that the combination therapy is more harmful than anticoagulant monotherapy for AF patients, especially for those with HF or CAD. Lastly, no-ATT group was associated with worse prognosis compared with other 3 groups. CONCLUSIONS: These results indicate that ATT is beneficial for AF patients particularly for those with HF, CAD, or non-paroxysmal AF and that among ATT, anticoagulant monotherapy may be most profitable for both clinical benefits and risks for AF patients.
Impacts of hippocampal blood flow on changes in left ventricular wall thickness in patients with chronic heart failure. 国際誌査読有り

Hideaki Suzuki, Yasuharu Matsumoto, Koichiro Sugimura, Jun Takahashi, Satoshi Miyata, Yoshihiro Fukumoto, Yasuyuki Taki, Hiroaki Shimokawa

International journal of cardiology　310　103-107　2020年1月10日

DOI： 10.1016/j.ijcard.2020.01.019 　

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BACKGROUND: Although depressive symptoms increased mortality and hospitalization in chronic heart failure (CHF) patients, the underlying mechanism remains unclear. The aim of this study was to investigate whether an alteration in hippocampal perfusion, which is the neural substrate of depressive symptoms, is associated with changes in cardiac structures and/or functions in CHF patients. METHODS: We used baseline data of 70 CHF patients (66.8 ± 8.9 yrs, 32.5% women), including cerebral blood flow (CBF) in the hippocampus, geriatric depression scale (GDS) scores and echocardiographic parameters, in the Brain Assessment and Investigation in Heart Failure Trial (B-HeFT) (UMIN000008584). Echocardiography was repeated at 3.1 ± 0.5 years after the baseline evaluation. We first tested voxel-wise regression model with hippocampal CBF as dependent variable and each of echocardiographic parameter change as independent variable, adjusted for age and sex. Structural equation modeling was used to test a mediation effect of cognitive test scores on associations between hippocampal perfusion and changes in cardiac structures and/or functions. RESULTS: Baseline anterior hippocampal CBF was negatively correlated with changes in left ventricular posterior wall thickness (PWT) (P < 0.05 with family-wise error corrections). An existence of depressive symptoms was positively correlated with the baseline anterior CBF and negatively with the PWT changes (P < 0.05, both). There were both direct effects of the baseline anterior hippocampal CBF on PWT thinning and effects mediated through the depressive symptoms (P < 0.05, both). CONCLUSIONS: This study provides the first evidence that the alteration in hippocampal perfusion may lead to changes in cardiac structures via increase in depressive symptoms in CHF patients.
冠動脈疾患における新規予後予測バイオマーカーAdipsinの発見補体系を介した心筋梗塞発症予測の新たな展開査読有り

大槻知広, 佐藤公雄, 清水亨, 池田尚平, 菊地順裕, 佐藤大樹, 黒澤亮, 野木正道, 砂村慎一郎, 矢尾板信裕, 大村淳一, 杉村宏一郎, 青木竜男, 建部俊介, 高橋潤, 宮田敏, 下川宏明

血管　43　(1)　36-36　2020年1月
出版者・発行元：日本心脈管作動物質学会
ISSN：0911-4637
Usefulness of intracoronary administration of fasudil, a selective Rho-kinase inhibitor, for PCI-related refractory myocardial ischemia. 国際誌査読有り

Yoku Kikuchi, Jun Takahashi, Kiyotaka Hao, Koichi Sato, Jun Sugisawa, Satoshi Tsuchiya, Akira Suda, Tomohiko Shindo, Shohei Ikeda, Takashi Shiroto, Yasuharu Matsumoto, Satoshi Miyata, Yasuhiko Sakata, Hiroaki Shimokawa

International journal of cardiology　297　8-13　2019年12月15日

DOI： 10.1016/j.ijcard.2019.09.057 　

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BACKGROUND: Intra-procedural myocardial ischemia as an iatrogenic complication still remains a critical issue in contemporary interventional cardiology. The aim of this study was to examine the usefulness of fasudil, a selective Rho-kinase inhibitor, for percutaneous coronary intervention (PCI)-related myocardial ischemia. METHODS: Among 448 PCI sessions performed between October 2015 and December 2017, we retrospectively examined 36 patients (69.0 ± 9.1 [SD] yrs., M/F 26/10) who underwent intracoronary administration of fasudil during a procedure to resolve myocardial ischemia that was resistant to intracoronary nitrate administration. RESULTS: The refractory myocardial ischemia was caused by distal embolization (69%), enhanced vasoconstriction at distal site of chronic total occlusion (11%), coronary spasm (11%), and coronary dissection (8%), most of which occurred immediately after balloon or stent dilatation. Intracoronary fasudil significantly improved corrected TIMI frame count (from 37 [30-56] to 24 [12-36]) and TIMI flow grade (from 2 [1-2.5] to 3 [2-3]) (both P < 0.001). Finally, 86% of all subjects successfully obtained TIMI flow grade 3 at the end of the procedure. Intracoronary fasudil tended to be more effective in patients with an attenuated plaque detected by intravascular ultrasound. Importantly, among the 19 elective cases, fasudil successfully prevented 17 patients from developing post-procedure myocardial infarction. Although fasudil-induced transient hypotension requiring a vasopressor was noted in 22% of the subjects, no other adverse effects were noted. CONCLUSIONS: These results indicate that fasudil is a useful and safe therapeutic option for PCI-related myocardial ischemia refractory intracoronary nitrate.
Identification of Adipsin as a Novel Prognostic Biomarker in Patients With Coronary Artery Disease. 国際誌査読有り

Tomohiro Ohtsuki, Kimio Satoh, Toru Shimizu, Shohei Ikeda, Nobuhiro Kikuchi, Taijyu Satoh, Ryo Kurosawa, Masamichi Nogi, Shinichiro Sunamura, Nobuhiro Yaoita, Junichi Omura, Tatsuo Aoki, Shunsuke Tatebe, Koichiro Sugimura, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

Journal of the American Heart Association　8　(23)　e013716　2019年12月3日

DOI： 10.1161/JAHA.119.013716 　

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Background Circulating proteins are exposed to vascular endothelial layer and influence their functions. Among them, adipsin is a member of the trypsin family of peptidases and is mainly secreted from adipocytes, monocytes, and macrophages, catalyzing the rate-limiting step of the alternative complement pathway. However, its pathophysiological role in cardiovascular disease remains to be elucidated. Here, we examined whether serum adipsin levels have a prognostic impact in patients with coronary artery disease. Methods and Results In 370 consecutive patients undergoing diagnostic coronary angiography, we performed a cytokine array analysis for screening serum levels of 50 cytokines/chemokines and growth factors. Among them, classification and regression analysis identified adipsin as the best biomarker for prediction of their long-term prognosis (median 71 months; interquartile range, 55-81 months). Kaplan-Meier curve showed that higher adipsin levels (≥400 ng/mL) were significantly associated with all-cause death (hazard ratio [HR], 4.2; 95% CI, 1.7-10.6 [P<0.001]) and rehospitalization (HR, 2.4; 95% CI, 1.7-3.5 [P<0.001]). Interestingly, higher high-sensitivity C-reactive protein levels (≥1 mg/L) were significantly correlated with all-cause death (HR, 3.2; 95% CI, 1.7-5.9 [P<0.001]) and rehospitalization (HR, 1.5, 95% CI, 1.1-1.9 [P<0.01]). Importantly, the combination of adipsin (≥400 ng/mL) and high-sensitivity C-reactive protein (≥1 mg/L) was more significantly associated with all-cause death (HR, 21.0; 95% CI, 2.9-154.1 [P<0.001]). Finally, the receiver operating characteristic curve demonstrated that serum adipsin levels predict the death caused by acute myocardial infarction in patients with coronary artery disease (C-statistic, 0.847). Conclusions These results indicate that adipsin is a novel biomarker that predicts all-cause death and rehospitalization in patients with coronary artery disease, demonstrating the novel aspects of the alternative complementary system in the pathogenesis of coronary artery disease.
Clinical Characteristics and In-Hospital Mortality According to Left Main and Non-Left Main Culprit Lesions - Report From the Japan Acute Myocardial Infarction Registry (JAMIR).

Kensaku Nishihira, Sunao Kojima, Misa Takegami, Satoshi Honda, Yoko M Nakao, Jun Takahashi, Tomonori Itoh, Tetsu Watanabe, Morimasa Takayama, Hiroaki Shimokawa, Tetsuya Sumiyoshi, Kazuo Kimura, Satoshi Yasuda

Circulation reports　1　(12)　601-609　2019年11月29日

DOI： 10.1253/circrep.CR-19-0056 　

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Background: Acute coronary syndrome (ACS) due to an unprotected left main coronary artery (LMCA) lesion is a critical condition, but there are limited data available on in-hospital outcomes of percutaneous coronary intervention (PCI). Methods and Results: The Japan Acute Myocardial Infarction Registry is a nationwide, real-world database. The clinical data on 13,548 ACS patients hospitalized between January 2011 and December 2013 were retrospectively collected from 10 representative regional ACS registry groups. We compared the 404 patients (3.0%) with LMCA ACS with the remaining 13,144 patients with non-LMCA ACS. The LMCA group was characterized by older age, lower rate of ST-segment elevation myocardial infarction, and higher rate of advanced Killip class. In-hospital mortality was significantly higher in patients with LMCA ACS than in those with non-LMCA ACS (23.3% vs. 5.5%, respectively; P<0.001). Primary PCI for non-LMCA lesions was associated with lower in-hospital mortality (OR, 0.48; 95% CI: 0.34-0.66), but that for LMCA lesions was not (OR, 2.89; 95% CI: 1.13-7.40). Longer door-to-balloon time was associated with Killip class ≥2 and higher in-hospital mortality in the non-LMCA group but not in the LMCA group. Conclusions: Primary PCI in patients with LMCA ACS is still challenging; therefore, effective strategies are needed.
Coronary Functional Abnormalities in Patients With Angina and Nonobstructive Coronary Artery Disease. 国際誌査読有り

Akira Suda, Jun Takahashi, Kiyotaka Hao, Yoku Kikuchi, Tomohiko Shindo, Shohei Ikeda, Koichi Sato, Jun Sugisawa, Yasuharu Matsumoto, Satoshi Miyata, Yasuhiko Sakata, Hiroaki Shimokawa

Journal of the American College of Cardiology　74　(19)　2350-2360　2019年11月12日

DOI： 10.1016/j.jacc.2019.08.1056 　

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BACKGROUND: Approximately one-half of patients undergoing diagnostic coronary angiography for angina have no significant coronary stenosis, in whom coronary functional abnormalities could be involved. OBJECTIVES: This study examined the significance of coronary functional abnormalities in a comprehensive manner for both epicardial and microvascular coronary arteries in patients with angina and nonobstructive coronary artery disease (CAD). METHODS: This study prospectively enrolled 187 consecutive patients (male/female 113/74, 63.2 ± 12.3 years), who underwent acetylcholine provocation test for coronary spasm and measurement of index of microcirculatory resistance (IMR) to evaluate coronary microvascular function, and followed them for a median of 893 days. RESULTS: Of all subjects, acetylcholine test identified 128 patients with vasospastic angina (VSA) (68%), and cardiac events occurred in 10 patients (5.3%) during the follow-up. Multivariable analysis revealed that IMR correlated with the incidence of cardiac events (hazard ratio: 1.05; 95% confidence interval: 1.02 to 1.09; p = 0.002) and receiver-operating characteristics (ROC) curve analysis identified IMR of 18.0 as the optimal cut-off value. Among the 4 groups based on the cut-off value of IMR and the presence of VSA, the Kaplan-Meier survival analysis showed a significantly worse prognosis in the group with high IMR (≥18.0) and VSA compared with other groups (log rank, p = 0.002). Importantly, intracoronary administration of fasudil, a Rho-kinase inhibitor, significantly ameliorated IMR in the VSA patients with increased IMR (p < 0.0001). CONCLUSIONS: These results indicate that in patients with angina and nonobstructive CAD, coexistence of epicardial coronary spasm and increased microvascular resistance is associated with worse prognosis, for which Rho-kinase activation may be involved.
Temporal trends in the prevalence and outcomes of geriatric patients with acute myocardial infarction in Japan-A report from the Miyagi AMI Registry Study. 国際誌査読有り

Koichi Sato, Jun Takahashi, Kiyotaka Hao, Satoshi Miyata, Akira Suda, Tomohiko Shindo, Shohei Ikeda, Yoku Kikuchi, Takashi Shiroto, Yasuharu Matsumoto, Yasuhiko Sakata, Hiroaki Shimokawa

Journal of cardiology　75　(5)　465-472　2019年11月12日

DOI： 10.1016/j.jjcc.2019.10.006 　

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BACKGROUND: Along with the global aging, the number of geriatric patients with acute myocardial infarction (AMI) has been increasing. However, temporal trends in the prevalence and outcomes of geriatric patients with AMI, with a special reference to heart failure (HF) on admission, remain to be elucidated. METHODS: The Miyagi AMI Registry is a prospective, multicenter, and observational study. This registry was established in 1979 and has been continued for 40 years. We examined a total of 6,596 AMI patients aged ≥70 years (male/female 4,141/2,455) registered in this registry from 2005 to 2016 and divided them into 3 groups according to age [70-79 (n = 3,485), 80-89 (n = 2,601), and ≥90 years (n = 510)]. RESULTS: Of those, 17.6% had HF (Killip class ≥ II) on admission, for which age, female sex, diabetes, and previous MI were identified as independent predictors. Importantly, the prevalence of HF on admission significantly increased in all ages during the study period (all p for trend <0.01). Despite the presence of HF on admission, primary percutaneous coronary intervention (PCI) was performed in about 70% of patients aged in their 80 s and about half of those aged ≥90 years. In each group, performance rate of primary PCI also progressively increased (all p < 0.05) irrespective of concomitant HF. However, in-hospital mortality remained unchanged. Multivariable analysis demonstrated that, even for patients with HF on admission, primary PCI was associated with improved in-hospital mortality in the younger 2 groups [adjusted odds ratios (ORs), 95% confidence intervals (CI) 0.58 (0.36-0.93) for 70s, 0.64 (0.43-0.95) for 80s, and 0.99 (0.44-2.21) for ≥90s], whereas PCI was ineffective to reduce long-term hospitalization ≥30 days in all groups [adjusted ORs (95%CI) 0.90 (0.52-1.54), 0.66 (0.38-1.14), and 0.38 (0.07-2.10)]. CONCLUSIONS: These results demonstrate that increasing prevalence of HF on admission and increasing performance of primary PCI counteract each other with resultant unchanged in-hospital outcomes in geriatric AMI patients in Japan.
Association between temporal changes in C-reactive protein levels and prognosis in patients with previous myocardial infarction - A report from the CHART-2 Study. 国際誌査読有り

Takuya Oikawa, Yasuhiko Sakata, Kotaro Nochioka, Masanobu Miura, Ruri Abe, Shintaro Kasahara, Masayuki Sato, Hajime Aoyanagi, Chiharu Saga, Yasuko Ikeno, Takashi Shiroto, Koichiro Sugimura, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

International journal of cardiology　293　17-24　2019年10月15日

DOI： 10.1016/j.ijcard.2019.07.022 　

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BACKGROUND: Several studies have reported that C-reactive protein (CRP), an inflammatory biomarker, predicts cardiovascular events independently of low-density lipoprotein cholesterol levels. However, no study examined whether temporal changes in CRP levels are associated with clinical events in patients with previous myocardial infarction (MI). METHODS AND RESULTS: We examined 2184 consecutive patients with previous MI and CRP data at baseline in the Chronic Heart Failure Registry and Analysis in the Tohoku district-2 (CHART-2) Study. During the median 6.4 years follow-up, 592 all-cause, 245 cardiovascular, and 273 non-cardiovascular deaths occurred. Patients with CRP ≥ 2.0 mg/L at baseline had significantly increased incidence of all-cause (hazard ratio (HR) 1.68, P < 0.001) and non-cardiovascular death (HR 1.86, P < 0.001), compared with those with CRP < 2.0 mg/L. Temporal changes in CRP levels were associated with prognosis; among patients with CRP ≥ 2.0 mg/L at baseline, those with CRP ≥ 2.0 mg/L at 1-year had significantly increased incidence of all-cause (HR 2.12, P < 0.001), cardiovascular (HR 2.31, P < 0.001), and non-cardiovascular death (HR 2.29, P < 0.001). Among patients with CRP < 2.0 mg/L at baseline, those with CRP ≥ 2.0 mg/L at 1-year had significantly increased incidence of all-cause (HR 1.76, P < 0.001) and cardiovascular death (HR 2.10, P = 0.001). These results remained significant after adjusted with the inverse probability of treatment weighted models using propensity sore. Furthermore, as compared with patients with CRP < 2.0 mg/L at both baseline and 1-year, those with CRP ≥ 2.0 mg/L at both baseline and 1-year had increased incidence of all-cause, cardiovascular, and non-cardiovascular death. CONCLUSIONS: These results provide the evidence that temporal increases in CRP levels are associated with increased clinical events in patients with previous MI.
経カテーテル的大動脈弁置換術後に認知機能が改善した超高齢重症大動脈弁狭窄症の1例

土屋聡, 松本泰治, 鈴木秀明, 菊地翼, 高橋潤, 熊谷紀一郎, 冨田尚希, 瀧靖之, 荒井啓行, 下川宏明

日本老年医学会雑誌　56　(4)　547-548　2019年10月
出版者・発行元： (一社)日本老年医学会
ISSN：0300-9173
非閉塞性冠動脈疾患における冠動脈機能異常の包括的評価査読有り

須田彬, 高橋潤, 羽尾清貴, 菊地翼, 進藤智彦, 佐藤公一, 杉澤潤, 松本泰治, 宮田敏, 坂田泰彦, 下川宏明

脈管学　59　(Suppl.)　S168-S169　2019年10月
出版者・発行元： (一社)日本脈管学会
ISSN：0387-1126

eISSN：1880-8840
Impaired glucose tolerance and albuminuria in patients with chronic heart failure: a subanalysis of the SUPPORT trial. 国際誌査読有り

Nochioka K, Sakata Y, Miura M, Shiroto T, Takahashi J, Saga C, Ikeno Y, Shiba N, Shinozaki T, Sugi M, Nakagawa M, Komaru T, Kato A, Nozaki E, Iwabuchi K, Hiramoto T, Inoue K, Ohe M, Tamaki K, Tsuji I, Shimokawa H

ESC heart failure　6　(6)　1252-1261　2019年10月

DOI： 10.1002/ehf2.12516 　
Clinical characteristics and long-term prognosis of contemporary patients with vasospastic angina: Ethnic differences detected in an international comparative study

Koichi Sato, Jun Takahashi, Yuji Odaka, Akira Suda, Shozo Sueda, Hiroki Teragawa, Katsuhisa Ishii, Takahiko Kiyooka, Atsushi Hirayama, Tetsuya Sumiyoshi, Yasuhiko Tanabe, Kazuo Kimura, Koichi Kaikita, Peter Ong, Udo Sechtem, Paolo G. Camici, Juan Carlos Kaski, Filippo Crea, John F. Beltrame, Hiroaki Shimokawa, Japanese Coronary Spasm Association

International Journal of Cardiology　291　13-18　2019年9月15日
出版者・発行元： Elsevier Ireland Ltd
DOI： 10.1016/j.ijcard.2019.02.038 　

ISSN：1874-1754 0167-5273
PCI関連心筋虚血に対する新たな治療法としての選択的Rho-kinase阻害薬ファスジルの冠動脈内投与

菊地翼, 高橋潤, 佐藤公一, 杉澤潤, 土屋聡, 須田彬, 進藤智彦, 神戸茂雄, 西宮健介, 白戸崇, 松本泰治, 坂田泰彦, 下川宏明

日本心血管インターベンション治療学会抄録集　28回　[MO90-004]　2019年9月
出版者・発行元： (一社)日本心血管インターベンション治療学会
高齢大動脈弁狭窄症患者に対する経カテーテル大動脈弁置換術は認知機能を改善する脳血流改善の意義

土屋聡, 松本泰治, 鈴木秀明, 杉澤潤, 須田彰, 佐藤公一, 進藤智彦, 池田尚平, 菊地翼, 西宮健介, 羽尾清貴, 高橋潤, 斎木佳克, 下川宏明

日本心血管インターベンション治療学会抄録集　28回　[MO164-004]　2019年9月
出版者・発行元： (一社)日本心血管インターベンション治療学会
PCI時代における冠動脈機能異常の重要性胸痛を有する非閉塞性冠動脈疾患患者における冠動脈機能異常に関する包括的評価

須田彬, 高橋潤, 羽尾清貴, 菊地翼, 進藤智彦, 池田尚平, 佐藤公一, 杉澤潤, 松本泰治, 宮田敏, 坂田泰彦, 下川宏明

日本心血管インターベンション治療学会抄録集　28回　[S28-2]　2019年9月
出版者・発行元： (一社)日本心血管インターベンション治療学会
レジストリー研究をACS診療に活かす実臨床における急性心筋梗塞後の抗血小板療法および虚血、出血イベント多施設急性心筋梗塞レジストリ(JAMIR)からの知見

本田怜史, 西平賢作, 竹上美沙, 小島淳, 浅海泰栄, 鈴木誠, 小菅雅美, 高橋潤, 坂田泰彦, 高山守正, 住吉徹哉, 小川久雄, 木村一雄, 安田聡

日本心臓病学会学術集会抄録　67回　SS-3　2019年9月
出版者・発行元： (一社)日本心臓病学会
本邦におけるAMIの実態と現状-レジストリーデータの重要性を考える- JAMIRからみるAMIの現状

小島淳, 本田怜史, 竹上未紗, 西平賢作, 浅海泰栄, 鈴木誠, 小菅雅美, 高橋潤, 坂田泰彦, 高山守正, 住吉徹哉, 小川久雄, 木村一雄, 安田聡

日本心血管インターベンション治療学会抄録集　28回　[S40-4]　2019年9月
出版者・発行元： (一社)日本心血管インターベンション治療学会
わが国の心不全高リスク患者(Stage B)における左室駆出率と予後との関連に関する検討 CHART-2研究からの知見査読有り

青柳肇, 坂田泰彦, 後岡広太郎, 白戸崇, 藤橋敬英, 山中信介, 林秀華, 杉村宏一郎, 高橋潤, 宮田敏, 下川宏明

日本心臓病学会学術集会抄録　67回　P-129　2019年9月
出版者・発行元： (一社)日本心臓病学会
Increased risk of cancer death in patients with chronic heart failure with a special reference to inflammation-A report from the CHART-2 Study. 国際誌査読有り

Oikawa T, Sakata Y, Nochioka K, Miura M, Abe R, Kasahara S, Sato M, Aoyanagi H, Shiroto T, Sugimura K, Takahashi J, Miyata S, Shimokawa H, CHART, Investigators

International journal of cardiology　290　106-112　2019年9月1日

DOI： 10.1016/j.ijcard.2019.04.078 　

ISSN：0167-5273
Disappearance of Angiodysplasia Following Transcatheter Aortic Valve Implantation in a Patient with Heyde's Syndrome: A Case Report and Review of the Literature. 査読有り

Tsuchiya S, Matsumoto Y, Doman T, Fujiya T, Sugisawa J, Suda A, Sato K, Ikeda S, Shindo T, Kikuchi Y, Hao K, Takahashi J, Hatta W, Koike T, Masamune A, Saiki Y, Horiuchi H, Shimokawa H

J Atheroscler Thromb　2019年8月
Contemporary Antiplatelet Therapy and Clinical Outcomes of Japanese Patients With Acute Myocardial Infarction - Results From the Prospective Japan Acute Myocardial Infarction Registry (JAMIR). 査読有り

Yasuda S, Honda S, Takegami M, Nishihira K, Kojima S, Asaumi Y, Suzuki M, Kosuge M, Takahashi J, Sakata Y, Takayama M, Sumiyoshi T, Ogawa H, Kimura K, JAMIR Investigators

Circulation journal : official journal of the Japanese Circulation Society　83　(8)　1633-1643　2019年7月

DOI： 10.1253/circj.CJ-19-0145 　

ISSN：1346-9843

eISSN：1347-4820
The 3A3B score: The simple risk score for heart failure with preserved ejection fraction - A report from the CHART-2 Study. 国際誌査読有り

Kasahara S, Sakata Y, Nochioka K, Tay WT, Claggett BL, Abe R, Oikawa T, Sato M, Aoyanagi H, Miura M, Shiroto T, Takahashi J, Sugimura K, Teng TK, Miyata S, Shimokawa H

International journal of cardiology　284　42-49　2019年6月1日

DOI： 10.1016/j.ijcard.2018.10.076 　

ISSN：0167-5273
高齢者の重症大動脈弁狭窄症患者に対する経カテーテル大動脈弁置換術は脳血流量と認知機能を改善する

土屋聡, 松本泰治, 鈴木秀明, 竹内雅史, 菊地翼, 高橋潤, 冨田尚希, 瀧靖之, 荒井啓行, 下川宏明

日本老年医学会雑誌　56　(Suppl.)　144-144　2019年5月
出版者・発行元： (一社)日本老年医学会
ISSN：0300-9173
Gender differences in prognostic relevance of self-care behaviors on mortality and hospitalization in patients with heart failure - A report from the CHART-2 Study. 国際誌査読有り

Abe R, Sakata Y, Nochioka K, Miura M, Oikawa T, Kasahara S, Sato M, Aoyanagi H, Shiroto T, Sugimura K, Takahashi J, Miyata S, Shimokawa H, CHART, Investigators

Journal of cardiology　73　(5)　370-378　2019年5月

DOI： 10.1016/j.jjcc.2018.11.006 　

ISSN：0914-5087
Elevated Serum Non-HDL (High-Density Lipoprotein) Cholesterol and Triglyceride Levels as Residual Risks for Myocardial Infarction Recurrence Under Statin Treatment. 国際誌査読有り

Suzuki K, Oikawa T, Nochioka K, Miura M, Kasahara S, Sato M, Aoyanagi H, Shiroto T, Takahashi J, Miyata S, Sakata Y, Shimokawa H

Arteriosclerosis, thrombosis, and vascular biology　39　(5)　934-944　2019年5月

DOI： 10.1161/ATVBAHA.119.312336 　

ISSN：1079-5642
Conversion formula from B-type natriuretic peptide to N-terminal proBNP values in patients with cardiovascular diseases. 国際誌査読有り

Kasahara S, Sakata Y, Nochioka K, Miura M, Abe R, Sato M, Aoyanagi H, Fujihashi T, Yamanaka S, Shiroto T, Sugimura K, Takahashi J, Miyata S, Shimokawa H

International journal of cardiology　280　184-189　2019年4月1日

DOI： 10.1016/j.ijcard.2018.12.069 　

ISSN：0167-5273
急性心筋梗塞を有する日本人患者における抗血小板療法および臨床転帰日本の急性心筋梗塞レジストリ(JAMIR)(Antiplatelet Therapy and Clinical Outcomes of Japanese Patients with Acute Myocardial Infarction: Japan Acute Myocardial Infarction Registry(JAMIR))

安田聡, 本田怜史, 西平賢作, 小島淳, 竹上未紗, 浅海泰栄, 鈴木誠, 小菅雅美, 高橋潤, 坂田泰彦, 高山守正, 住吉徹哉, 小川久雄, 木村一雄

日本循環器学会学術集会抄録集　83回　LBCS4-1　2019年3月
出版者・発行元： (一社)日本循環器学会
レジストリーによる脳卒中と循環器疾患の診療実態大規模コホート試験において脳卒中と抗血栓療法が予後に与える影響 CHART-2試験からの実臨床データ(Prognostic Impacts of Stroke and Antithrombotic Therapies in a Large-scale Cohort Study: Real-world Data from the CHART-2 Study) 査読有り

白戸崇, 坂田泰彦, 後岡広太郎, 三浦正暢, 阿部瑠璃, 笠原信太郎, 佐藤雅之, 青柳肇, 山中信介, 藤橋敬英, 高橋潤, 宮田敏, 下川宏明

日本循環器学会学術集会抄録集　83回　SY26-5　2019年3月
出版者・発行元： (一社)日本循環器学会
左室駆出率の保たれた心不全患者に対する簡便で有用なリスクスコアとしての3A3Bスコア(3A3B Score as a Simple and Useful Risk Score for Patients with Heart Failure with Preserved Left Ventricular Ejection Fraction) 査読有り

笠原信太郎, 坂田泰彦, 後岡広太郎, Tay Wan Ting, Claggett Brian Lee, 阿部瑠璃, 佐藤雅之, 青柳肇, 藤橋敬英, 山中信介, 三浦正暢, 白戸崇, 高橋潤, 杉村宏一郎, Teng Tiew-Hwa Katherine, 宮田敏, 下川宏明

日本循環器学会学術集会抄録集　83回　OJ03-6　2019年3月
出版者・発行元： (一社)日本循環器学会
将来の心不全症状増悪に関連する脳領域(Brain Areas Associated with Future Exacerbation of Heart Failure Symptoms) 査読有り

鈴木秀明, 松本泰治, 杉村宏一郎, 高橋潤, 宮田敏, 福本義弘, 瀧靖之, 下川宏明

日本循環器学会学術集会抄録集　83回　OJ04-6　2019年3月
出版者・発行元： (一社)日本循環器学会
心不全リスクのある患者における左室駆出率の推移の影響 CHART-2研究からの報告(Impact of Transition of Left Ventricular Ejection Fraction in Patients at Risk of Heart Failure: Report from the CHART-2 Study) 査読有り

青柳肇, 坂田泰彦, 後岡広太郎, 三浦正暢, 笠原信太郎, 佐藤雅之, 藤橋敬英, 山中信介, 白戸崇, 杉村宏一郎, 高橋潤, 宮田敏, 下川宏明

日本循環器学会学術集会抄録集　83回　PJ073-5　2019年3月
出版者・発行元： (一社)日本循環器学会
Prognostic impact of residual stenosis after percutaneous coronary intervention in patients with ischemic heart failure - A report from the CHART-2 study. 国際誌査読有り

Kiyotaka Hao, Jun Takahashi, Yasuhiko Sakata, Satoshi Miyata, Takashi Shiroto, Kotaro Nochioka, Masanobu Miura, Takuya Oikawa, Ruri Abe, Masayuki Sato, Shintaro Kasahara, Hajime Aoyanagi, Hiroaki Shimokawa

International journal of cardiology　278　22-27　2019年3月1日

DOI： 10.1016/j.ijcard.2018.10.062 　

ISSN：0167-5273

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BACKGROUND: Complete revascularization with PCI is not always achieved in patients with ischemic HF. Therefore, this study aimed to elucidate the prognostic impact of residual coronary stenosis (RS) after percutaneous coronary intervention (PCI) in patients with ischemic heart failure (HF). METHODS: We analyzed a total of 1307 patients with symptomatic HF and a history of PCI registered in our Chronic Heart Failure Analysis and Registry in the Tohoku District-2 (CHART-2) Study. RS that was defined as the presence of ≥70% luminal stenosis in major coronary arteries at the last coronary angiography. RESULTS: Among the study population, 851 patients (65.1%) had RS. During a median follow-up period of 3.2 years, patients with RS had higher all-cause mortality than those without it even after propensity score matching (21.9 vs. 11.6%, log-rank P = 0.027). Multivariable Cox hazard analysis also showed the negative impact of RS on all-cause death in ischemic HF patients [hazard ratio (HR):1.62, 95% confidence interval (CI): 1.07-2.46, P = 0.024]. Importantly, when divided all subjects into three subgroups by left ventricular ejection fraction (LVEF) [LVEF < 40% (HFrEF), LVEF 40-49% (HFmrEF), and LVEF ≥ 50% (HFpEF)], inverse probability of treatment weighted method provided a similar result that RS after PCI was an independent risk factor for death in the HFpEF [HR(95%CI); 1.94(1.22-3.09), P < 0.01] and HFmrEF [4.47(1.13-14.98), P < 0.01] groups, but not in the HFrEF group [1.20(0.59-2.43), P = 0.62]. CONCLUSIONS: These results indicate that RS after PCI could aggravate long-term prognosis of ischemic HF patients with moderate- to well-preserved EF, but not those with reduced EF.
Rationale, Design, and Baseline Characteristics of the Prospective Japan Acute Myocardial Infarction Registry (JAMIR). 国際誌査読有り

Honda S, Nishihira K, Kojima S, Takegami M, Asaumi Y, Suzuki M, Kosuge M, Takahashi J, Sakata Y, Takayama M, Sumiyoshi T, Ogawa H, Kimura K, Yasuda S, JAMIR investigators

Cardiovascular drugs and therapy　33　(1)　97-103　2019年2月

DOI： 10.1007/s10557-018-6839-1 　

ISSN：0920-3206
A multicenter trial of extracorporeal cardiac shock wave therapy for refractory angina pectoris: report of the highly advanced medical treatment in Japan. 査読有り

Yoku Kikuchi, Kenta Ito, Tomohiko Shindo, Kiyotaka Hao, Takashi Shiroto, Yasuharu Matsumoto, Jun Takahashi, Takao Matsubara, Akira Yamada, Yukio Ozaki, Michiaki Hiroe, Kazuo Misumi, Hideki Ota, Kentaro Takanami, Tomomichi Hiraide, Kei Takase, Fumiya Tanji, Yasutake Tomata, Ichiro Tsuji, Hiroaki Shimokawa

Heart and vessels　34　(1)　104-113　2019年1月

DOI： 10.1007/s00380-018-1215-4 　

ISSN：0910-8327

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We have previously demonstrated that cardiac shock wave therapy (CSWT) effectively improves myocardial ischemia through coronary neovascularization both in a porcine model of chronic myocardial ischemia and in patients with refractory angina pectoris (AP). In this study, we further addressed the efficacy and safety of CSWT in a single-arm multicenter study approved as a highly advanced medical treatment by the Japanese Ministry of Health, Labour and Welfare. Fifty patients with refractory AP [mean age 70.9 ± 12.6 (SD) years, M/F 38/12] without the indications of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) were enrolled in 4 institutes in Japan. Ischemic myocardial regions in the left ventricle (LV) were identified by drug-induced stress myocardial perfusion imaging (MPI). Shock waves (200 shots/spot at 0.09 mJ/mm2) were applied to 40-60 spots in the ischemic myocardium 3 times in the first week. The patients were followed up for 3 months thereafter. Forty-one patients underwent CSWT and completed the follow-up at 3 months. CSWT markedly improved weekly nitroglycerin use [from 3.5 (IQR 2 to 6) to 0 (IQR 0 to 1)] and the symptoms [Canadian Cardiovascular Society functional class score, from 2 (IQR 2 to 3) to 1 (IQR 1 to 2)] (both P < 0.001). CSWT also significantly improved 6-min walking distance (from 384 ± 91 to 435 ± 122 m, P < 0.05). There were no significant changes in LV ejection fraction evaluated by echocardiography and LV stroke volume evaluated by cardiac magnetic resonance imaging (from 56.3 ± 14.7 to 58.8 ± 12.8%, P = 0.10, and from 52.3 ± 17.4 to 55.6 ± 15.7 mL, P = 0.15, respectively). Percent myocardium ischemia assessed by drug-induced stress MPI tended to be improved only in the treated segments (from 16.0 ± 11.1 to 12.1 ± 16.2%, P = 0.06), although no change was noted in the whole LV. No procedural complications or adverse effects related to the CSWT were noted. These results of the multicenter trial further indicate that CSWT is a useful and safe non-invasive strategy for patients with refractory AP with no options of PCI or CABG.
Comparable prognostic impact of BNP levels among HFpEF, Borderline HFpEF and HFrEF: a report from the CHART-2 Study. 査読有り

Shintaro Kasahara, Yasuhiko Sakata, Kotaro Nochioka, Takeshi Yamauchi, Takeo Onose, Kanako Tsuji, Ruri Abe, Takuya Oikawa, Masayuki Sato, Hajime Aoyanagi, Masanobu Miura, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

Heart and vessels　33　(9)　997-1007　2018年9月

DOI： 10.1007/s00380-018-1150-4 　

ISSN：0910-8327

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We aimed to compare the usefulness of plasma levels of B-type natriuretic peptide (BNP) for long-term risk stratification among patients with heart failure (HF) with preserved left ventricular ejection fraction (LVEF) (HFpEF), borderline HFpEF, and HF with reduced LVEF (HFrEF) in the same HF cohort. In the CHART-2 Study (N = 10,219), we categorized 4301 consecutive Stage C/D HF patients (mean age 68.7 years, female 32.4%) into 3 groups: HFpEF (LVEF ≥ 50%, N = 2893), borderline HFpEF (LVEF 40-50%, N = 666), and HFrEF (LVEF ≤ 40%, N = 742). During the median 6.3-year follow-up, all-cause deaths occurred in 887 HFpEF, 330 borderline HFpEF, and 330 HFrEF patients. Although median BNP levels increased from HFpEF, borderline HFpEF to HFrEF (85.3, 126 and 208 pg/ml, respectively, P < 0.001), the relationship between log2 BNP levels and the mortality risk was comparable among the 3 groups. As compared with patients with BNP < 30 pg/ml, those with 30-99, 100-299 and ≥ 300 pg/ml had comparably increasing mortality risk among the 3 groups (hazard ratio 2.5, 4.7 and 7.8 in HFpEF, 2.1, 4.2 and 7.0 in borderline HFpEF, and 3.0, 4.7 and 9.5 in HFrEF, respectively, all P < 0.001). BNP levels have comparable prognostic impact among HFpEF, borderline HFpEF, and HFrEF patients.
Nationwide real-world database of 20,462 patients enrolled in the Japanese Acute Myocardial Infarction Registry (JAMIR): Impact of emergency coronary intervention in a super-aging population 査読有り

Sunao Kojima, Kensaku Nishihira, Misa Takegami, Yoko M. Nakao, Satoshi Honda, Jun Takahashi, Morimasa Takayama, Hiroaki Shimokawa, Tetsuya Sumiyoshi, Hisao Ogawa, Kazuo Kimura, Satoshi Yasuda, JAMIR Investigators

IJC Heart and Vasculature　20　1-6　2018年9月1日
出版者・発行元： Elsevier Ireland Ltd
DOI： 10.1016/j.ijcha.2018.06.003 　

ISSN：2352-9067
PCI関連心筋虚血に対する選択的Rho-kinase阻害薬ファスジルの冠動脈内投与の有効性

菊地翼, 高橋潤, 佐藤公一, 杉澤潤, 土屋聡, 須田彬, 進藤智彦, 池田尚平, 羽尾清貴, 白戸崇, 松本泰治, 坂田泰彦, 下川宏明

日本心血管インターベンション治療学会抄録集　27回　MO005-MO005　2018年8月
出版者・発行元： (一社)日本心血管インターベンション治療学会
心不全患者における冠動脈インターベンション後の残存狭窄が予後に及ぼす影響査読有り

羽尾清貴, 高橋潤, 坂田泰彦, 宮田敏, 白戸崇, 後岡広太郎, 三浦正暢, 下川宏明

日本心血管インターベンション治療学会抄録集　27回　MO066-MO066　2018年8月
出版者・発行元： (一社)日本心血管インターベンション治療学会
Low-energy cardiac shockwave therapy to suppress left ventricular remodeling in patients with acute myocardial infarction: a first-in-human study. 国際誌査読有り

Yuta Kagaya, Kenta Ito, Jun Takahashi, Yasuharu Matsumoto, Takashi Shiroto, Ryuji Tsuburaya, Yoku Kikuchi, Kiyotaka Hao, Kensuke Nishimiya, Tomohiko Shindo, Tsuyoshi Ogata, Ryo Kurosawa, Kumiko Eguchi, Yuto Monma, Sadamitsu Ichijo, Kazuaki Hatanaka, Satoshi Miyata, Hiroaki Shimokawa

Coronary artery disease　29　(4)　294-300　2018年6月

DOI： 10.1097/MCA.0000000000000577 　

ISSN：0954-6928

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OBJECTIVE: Although primary percutaneous coronary intervention (PCI) substantially reduces the mortality of patients with acute myocardial infarction (AMI), left ventricular (LV) remodeling after AMI still remains an important issue in cardiovascular medicine. We have previously demonstrated that low-energy cardiac shockwave (SW) therapy ameliorates LV remodeling after AMI in pigs. In this first-in-human study, we examined the feasibility and the effects of the SW therapy on LV remodeling after AMI in humans. PATIENTS AND METHODS: Seventeen patients with AMI who successfully underwent primary PCI (peak-creatine kinase<4000 U/l) were treated with the SW therapy. Low-energy shock waves were applied to the ischemic border zone around the infarcted area at 2, 4, and 6 days since AMI. Next, we compared these patients with historical AMI controls by propensity score matching (N=25). RESULTS: There were no procedure-related complications or adverse effects. At 6 and 12 months after AMI, LV function as assessed by MRI showed no signs of deleterious LV remodeling. When we compared the SW-treated group with the historical AMI controls at 6 months after AMI, LV ejection fraction was significantly higher in the SW-treated group (N=7) than in the historical control group (N=25) by echocardiography (66±7 vs. 58±12%, P<0.05). LV end-diastolic dimension also tended to be smaller in the SW than in the control group (47.5±4.6 vs. 50.0±5.9 mm, P=0.29). CONCLUSION: These results suggest that low-energy extracorporeal cardiac SW therapy is feasible and may ameliorate postmyocardial infarction LV remodeling in patients with AMI as an adjunctive therapy to primary PCI.
Reply: New Aspects of Vasospastic Angina: Coronary Adventitial and Perivascular Adipose Tissue Inflammation. 国際誌査読有り

Ohyama K, Matsumoto Y, Takahashi J, Takanami K, Shimokawa H

Journal of the American College of Cardiology　71　(23)　2709-2710　2018年6月

DOI： 10.1016/j.jacc.2018.03.510 　

ISSN：0735-1097
High-Dose Versus Low-Dose Pitavastatin in Japanese Patients With Stable Coronary Artery Disease (REAL-CAD): A Randomized Superiority Trial. 国際誌査読有り

Isao Taguchi, Satoshi Iimuro, Hiroshi Iwata, Hiroaki Takashima, Mitsuru Abe, Eisuke Amiya, Takanori Ogawa, Yukio Ozaki, Ichiro Sakuma, Yoshihisa Nakagawa, Kiyoshi Hibi, Takafumi Hiro, Yoshihiro Fukumoto, Seiji Hokimoto, Katsumi Miyauchi, Tsutomu Yamazaki, Hiroshi Ito, Yutaka Otsuji, Kazuo Kimura, Jun Takahashi, Atsushi Hirayama, Hiroyoshi Yokoi, Kazuo Kitagawa, Takao Urabe, Yasushi Okada, Yasuo Terayama, Kazunori Toyoda, Takehiko Nagao, Masayasu Matsumoto, Yasuo Ohashi, Tetsuji Kaneko, Retsu Fujita, Hiroshi Ohtsu, Hisao Ogawa, Hiroyuki Daida, Hiroaki Shimokawa, Yasushi Saito, Takeshi Kimura, Teruo Inoue, Masunori Matsuzaki, Ryozo Nagai

Circulation　137　(19)　1997-2009　2018年5月8日

DOI： 10.1161/CIRCULATIONAHA.117.032615 　

ISSN：0009-7322

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BACKGROUND: Current guidelines call for high-intensity statin therapy in patients with cardiovascular disease on the basis of several previous "more versus less statins" trials. However, no clear evidence for more versus less statins has been established in an Asian population. METHODS: In this prospective, multicenter, randomized, open-label, blinded end point study, 13 054 Japanese patients with stable coronary artery disease who achieved low-density lipoprotein cholesterol (LDL-C) <120 mg/dL during a run-in period (pitavastatin 1 mg/d) were randomized in a 1-to-1 fashion to high-dose (pitavastatin 4 mg/d; n=6526) or low-dose (pitavastatin 1 mg/d; n=6528) statin therapy. The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal ischemic stroke, or unstable angina requiring emergency hospitalization. The secondary composite end point was a composite of the primary end point and clinically indicated coronary revascularization excluding target-lesion revascularization at sites of prior percutaneous coronary intervention. RESULTS: The mean age of the study population was 68 years, and 83% were male. The mean LDL-C level before enrollment was 93 mg/dL with 91% of patients taking statins. The baseline LDL-C level after the run-in period on pitavastatin 1 mg/d was 87.7 and 88.1 mg/dL in the high-dose and low-dose groups, respectively. During the entire course of follow-up, LDL-C in the high-dose group was lower by 14.7 mg/dL than in the low-dose group (P<0.001). With a median follow-up of 3.9 years, high-dose as compared with low-dose pitavastatin significantly reduced the risk of the primary end point (266 patients [4.3%] and 334 patients [5.4%]; hazard ratio, 0.81; 95% confidence interval, 0.69-0.95; P=0.01) and the risk of the secondary composite end point (489 patients [7.9%] and 600 patients [9.7%]; hazard ratio, 0.83; 95% confidence interval, 0.73-0.93; P=0.002). High-dose pitavastatin also significantly reduced the risks of several other secondary end points such as all-cause death, myocardial infarction, and clinically indicated coronary revascularization. The results for the primary and the secondary composite end points were consistent across several prespecified subgroups, including the low (<95 mg/dL) baseline LDL-C subgroup. Serious adverse event rates were low in both groups. CONCLUSIONS: High-dose (4 mg/d) compared with low-dose (1 mg/d) pitavastatin therapy significantly reduced cardiovascular events in Japanese patients with stable coronary artery disease. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01042730.
Structural brain abnormalities and cardiac dysfunction in patients with chronic heart failure. 国際誌査読有り

Hideaki Suzuki, Yasuharu Matsumoto, Hideki Ota, Koichiro Sugimura, Jun Takahashi, Kenta Ito, Satoshi Miyata, Yoshihiro Fukumoto, Yasuyuki Taki, Hiroaki Shimokawa

European journal of heart failure　20　(5)　936-938　2018年5月

DOI： 10.1002/ejhf.1104 　

ISSN：1388-9842
Prognostic impacts of Rho-kinase activity in circulating leucocytes in patients with vasospastic angina. 国際誌査読有り

Taro Nihei, Jun Takahashi, Kiyotaka Hao, Yoku Kikuchi, Yuji Odaka, Ryuji Tsuburaya, Kensuke Nishimiya, Yasuharu Matsumoto, Kenta Ito, Satoshi Miyata, Yasuhiko Sakata, Hiroaki Shimokawa

European heart journal　39　(11)　952-959　2018年3月14日

DOI： 10.1093/eurheartj/ehx657 　

ISSN：0195-668X

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Aims: Rho-kinase activity in circulating leucocytes is a useful biomarker for diagnosis and disease activity assessment of vasospastic angina (VSA). The present study aimed to examine the long-term prognostic impact of Rho-kinase activity in circulating leucocytes in VSA patients. Methods and results: We prospectively enrolled 174 consecutive patients with VSA and 50 non-VSA patients, in whom we measured Rho-kinase activity in circulating leucocytes, and they were followed for a median of 16 months. The primary endpoint was cardiac events including cardiac death, non-fatal myocardial infarction, and hospitalization for unstable angina. During the follow-up period, cardiac events occurred in 10 VSA patients (5.7%) but in none of the non-VSA patients. When we divided VSA patients into two groups by a median value of their Rho-kinase activity, the Kaplan-Meier survival analysis showed a significantly worse prognosis in VSA patients with high Rho-kinase activity compared with those with low activity or non-VSA patients (log-rank; P < 0.05, respectively). Receiver-operating characteristic curve analysis showed that Rho-kinase activity value of 1.24 was the best cut-off level to predict cardiac events in VSA patients, and multivariable analysis showed that a value above the cut-off point had the largest hazard ratio to predict poor outcome in VSA patients [hazard ratio (95% confidence interval) 11.19 (1.41-88.95); P = 0.022]. Importantly, combination of the Japanese Coronary Spasm Association risk score and Rho-kinase activity significantly improved the prognostic impact in VSA patients as compared with either alone. Conclusion: Rho-kinase activity in circulating leucocytes is useful for prognostic stratification of VSA patients.
Prognostic Impact of Statin Intensity in Heart Failure Patients With Ischemic Heart Disease: A Report From the CHART-2 (Chronic Heart Failure Registry and Analysis in the Tohoku District 2) Study. 国際誌査読有り

Takuya Oikawa, Yasuhiko Sakata, Kotaro Nochioka, Masanobu Miura, Kanako Tsuji, Takeo Onose, Ruri Abe, Shintaro Kasahara, Masayuki Sato, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

Journal of the American Heart Association　7　(6)　2018年3月14日

DOI： 10.1161/JAHA.117.007524 　

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BACKGROUND: The beneficial prognostic impact of statins has been established in patients with ischemic heart disease but not in those with heart failure (HF). In addition, it is still unclear whether patients benefit from statins regardless of low-density lipoprotein cholesterol levels. METHODS AND RESULTS: We examined 2444 consecutive stage C or D HF patients with ischemic heart disease registered in CHART-2 (Chronic Heart Failure Registry and Analysis in the Tohoku District 2), a multicenter, prospective, observational cohort study in Japan. Patients were divided into 3 groups according to the Japanese standard doses of statins and statin-intensity categories defined by the 2013 American College of Cardiology and American Heart Association guidelines: higher (moderate-high)-intensity (n=868), lower (low)-intensity (n=526), and no statin (n=1050). The median follow-up period was 6.4 years (13929 person-years). Analysis with the inverse probability of treatment weighted using a propensity score for multiple treatment revealed that both the higher-intesity group (hazard ratio [HR]: 0.68; P<0.001) and the lower-intensity group (HR: 0.82; P<0.001) had significantly lower incidence of the primary end point-a composite of all-cause death and HF admission-compared with the no statin group. The higher-intensity statin group had significantly lower incidence of the primary end point (HR: 0.82; P<0.001), all-cause death (HR: 0.83; P<0.001), and HF admission (HR: 0.78; P<0.001) than the lower-intensity statin group. Moreover, the use of statins, either higher- or lower-intensity, was associated with reduced incidence of the primary end point, regardless of low-density lipoprotein cholesterol levels. CONCLUSIONS: These results suggest that statin use, particularly the use of higher-intensity statins, has a beneficial prognostic impact in HF patients with ischemic heart disease, regardless of low-density lipoprotein cholesterol levels. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00418041.
多様化する医療に向けて臨床研究の方向性を再考する地域レジストリを統合して確立した日本急性心筋梗塞レジストリ(JAMIR)の全国規模の実地臨床データベース(Nationwide Real-World Database of the Japanese Acute Myocardial Infarction Registry(JAMIR) Established by Integration of the Regional Registries)

小島淳, 西平賢作, 竹上未紗, 中尾葉子, 本田怜史, 高橋潤, 高山守正, 住吉徹哉, 木村一雄, 小川久雄, 安田聡

日本循環器学会学術集会抄録集　82回　SY09-1　2018年3月
出版者・発行元： (一社)日本循環器学会
慢性心不全患者において耐糖能障害が微量アルブミン尿との関連で予後に及ぼす影響 SUPPORT試験のサブ解析(Prognostic Impact of Impaired Glucose Tolerance in Relation with Microalbuminuria in Patients with Chronic Heart Failure: The SUPPORT Trial Subanalysis) 査読有り

後岡広太郎, 坂田泰彦, 白戸崇, 及川卓也, 阿部瑠璃, 笠原信太郎, 佐藤雅之, 青柳肇, 高橋潤, 宮田敏, 下川宏明

日本循環器学会学術集会抄録集　82回　LBCS2-2　2018年3月
出版者・発行元： (一社)日本循環器学会
B-type natriuretic peptide値とN-terminal Pro BNP値間の換算式の開発(Development of a Conversion Formula between B-type Natriuretic Peptide and N-terminal Pro BNP Levels) 査読有り

笠原信太郎, 坂田泰彦, 後岡広太郎, 阿部瑠璃, 及川卓也, 佐藤雅之, 青柳肇, 三浦正暢, 白戸崇, 高橋潤, 宮田敏, 下川宏明

日本循環器学会学術集会抄録集　82回　OJ03-2　2018年3月
出版者・発行元： (一社)日本循環器学会
心不全リスクのある患者における左室駆出率推移の影響 CHART-2 Studyからの報告(Impact of Transition of Left Ventricular Ejection Fraction in Patients at Risk for Heart Failure: Report from the CHART-2 Study) 査読有り

青柳肇, 坂田泰彦, 後岡広太郎, 白戸崇, 及川卓也, 阿部瑠璃, 笠原信太郎, 佐藤雅之, 高橋潤, 宮田敏, 下川宏明

日本循環器学会学術集会抄録集　82回　OJ20-3　2018年3月
出版者・発行元： (一社)日本循環器学会
慢性心不全患者の健康意識と予後に関する性差 CHART-2試験からの報告(Sex Differences in Health Consciousness and Prognosis of Patients with Chronic Heart Failure: A Report from the CHART-2 Study) 査読有り

阿部瑠璃, 坂田泰彦, 後岡広太郎, 及川卓也, 笠原信太郎, 佐藤雅之, 青柳肇, 三浦正暢, 白戸崇, 高橋潤, 宮田敏, 下川宏明

日本循環器学会学術集会抄録集　82回　PJ002-1　2018年3月
出版者・発行元： (一社)日本循環器学会
心筋梗塞患者の二次予防におけるトリグリセリドレベルの予後への影響 CHART-2研究からの報告(Prognostic Impact of Triglycerides Levels in the Secondary Prevention of Patients with Myocardial Infarction: A Report from the CHART-2 Study) 査読有り

及川卓也, 坂田泰彦, 後岡広太郎, 三浦正暢, 阿部瑠璃, 笠原信太郎, 佐藤雅之, 青柳肇, 白戸崇, 高橋潤, 宮田敏, 下川宏明

日本循環器学会学術集会抄録集　82回　PJ074-2　2018年3月
出版者・発行元： (一社)日本循環器学会
Coronary Adventitial and Perivascular Adipose Tissue Inflammation in Patients With Vasospastic Angina. 国際誌査読有り

Ohyama K, Matsumoto Y, Takanami K, Ota H, Nishimiya K, Sugisawa J, Tsuchiya S, Amamizu H, Uzuka H, Suda A, Shindo T, Kikuchi Y, Hao K, Tsuburaya R, Takahashi J, Miyata S, Sakata Y, Takase K, Shimokawa H

Journal of the American College of Cardiology　71　(4)　414-425　2018年1月30日

DOI： 10.1016/j.jacc.2017.11.046 　

ISSN：0735-1097
Absence of adventitial vasa vasorum formation at the coronary segment with myocardial bridge - An optical coherence tomography study 査読有り

Kensuke Nishimiya, Yasuharu Matsumoto, Hongxin Wang, Zhonglie Piao, Kazuma Ohyama, Hironori Uzuka, Kiyotaka Hao, Ryuji Tsuburaya, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa

INTERNATIONAL JOURNAL OF CARDIOLOGY　250　275-277　2018年1月

DOI： 10.1016/j.ijcard.2017.09.211 　

ISSN：0167-5273

eISSN：1874-1754
European Society of Cardiology (ESC) Annual Congress Report From Barcelona 2017 査読有り

Kimio Satoh, Jun Takahashi, Yasuharu Matsumoto, Shunsuke Tatebe, Tatsuo Aoki, Yoku Kikuchi, Kiyotaka Hao, Kazuma Ohyama, Masamichi Nogi, Akira Suda, Shintaro Kasahara, Koichi Sato, Sadamitsu Ichijo, Hiroaki Shimokawa

CIRCULATION JOURNAL　81　(12)　1758-1763　2017年12月

DOI： 10.1253/circj.CJ-17-1103 　

ISSN：1346-9843

eISSN：1347-4820
Characterization of heart failure patients with mid-range left ventricular ejection fraction-a report from the CHART-2 Study. 国際誌査読有り

Kanako Tsuji, Yasuhiko Sakata, Kotaro Nochioka, Masanobu Miura, Takeshi Yamauchi, Takeo Onose, Ruri Abe, Takuya Oikawa, Shintaro Kasahara, Masayuki Sato, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

European journal of heart failure　19　(10)　1258-1269　2017年10月

DOI： 10.1002/ejhf.807 　

ISSN：1388-9842

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BACKGROUND: The new category of heart failure (HF), HF with mid-range left ventricular ejection fraction (LVEF) (HFmrEF), has recently been proposed. However, the clinical features of HFmrEF, with reference to HF with preserved LVEF (HFpEF) and HF with reduced LVEF (HFrEF) in the same HF cohort, remain to be fully examined. METHODS AND RESULTS: In the Chronic Heart Failure Analysis and Registry in the Tohoku District-2 Study, we examined 3480 consecutive HF patients with echocardiography data consisting of 2154 HFpEF (LVEF ≥50%), 596 HFmrEF (LVEF 40-49%) and 730 HFrEF (LVEF <40%). While clinical characteristics and prognostic factors of HFmrEF were intermediate between HFpEF and HFrEF, prognosis of HFmrEF resembled HFpEF and the prognostic impact of cardiovascular medications in HFmrEF resembled that of HFrEF. Analysis of LVEF transition among the three groups revealed that HFmrEF and HFrEF dynamically transitioned to other categories, especially within 1 year, whereas HFpEF did not; HFmrEF at registration transitioned to HFpEF and HFrEF by 44% and 16% at 1 year, and 45% and 21% at 3 years, respectively. Landmark analysis demonstrated that, regardless of HF stages at registration, HFmrEF patients at 1 year had mortality comparable to that of HFpEF patients, which was better than HFrEF patients, but HFmrEF patients at registration had increased mortality when transitioned to HFrEF at 1 year. CONCLUSIONS: These results indicate that clinical characteristics of HFmrEF are intermediate between HFpEF and HFrEF and that HFmrEF dynamically transitions to HFpEF or HFrEF, especially within 1 year, suggesting that HFmrEF represents a transitional status or an overlap zone between HFpEF and HFrEF, rather than an independent entity of HF.
Renal Denervation Suppresses Coronary Hyperconstricting Responses After Drug-Eluting Stent Implantation in Pigs In Vivo Through the Kidney-Brain-Heart Axis. 国際誌査読有り

Hironori Uzuka, Yasuharu Matsumoto, Kensuke Nishimiya, Kazuma Ohyama, Hideaki Suzuki, Hirokazu Amamizu, Susumu Morosawa, Michinori Hirano, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Takashi Shiroto, Kenta Ito, Jun Takahashi, Koji Fukuda, Satoshi Miyata, Yoshihito Funaki, Hatsue Ishibashi-Ueda, Satoshi Yasuda, Hiroaki Shimokawa

Arteriosclerosis, thrombosis, and vascular biology　37　(10)　1869-1880　2017年10月

DOI： 10.1161/ATVBAHA.117.309777 　

ISSN：1079-5642

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OBJECTIVE: Drug-eluting stent-induced coronary hyperconstricting responses remain an important issue. The adventitia harbors a variety of components that potently modulate vascular tone, including sympathetic nerve fibers (SNF) and vasa vasorum. Catheter-based renal denervation (RDN) inhibits sympathetic nerve activity. We, thus, examined whether RDN suppresses drug-eluting stent-induced coronary hyperconstricting responses, and if so, what mechanisms are involved. APPROACH AND RESULTS: Protocol 1: pigs implanted with everolimus-eluting stents into the left coronary arteries underwent coronary angiography at 1 month after implantation for assessment of coronary vasomotion and adventitial SNF formation. Drug-eluting stent-induced coronary hyperconstricting responses were significantly enhanced associated with enhanced coronary adventitial SNF and vasa vasorum formation. Protocol 2: pigs implanted with everolimus-eluting stents were randomly assigned to the RDN or sham group. The RDN group underwent renal ablation. At 1 month, RDN significantly caused marked damage of the SNF at the renal arteries without any stenosis, thrombus, or dissections. Notably, RDN significantly upregulated the expression of α2-adrenergic receptor-binding sites in the nucleus tractus solitarius, attenuated muscle sympathetic nerve activity, and decreased systolic blood pressure and plasma renin activity. In addition, RDN attenuated coronary hyperconstricting responses to intracoronary serotonin at the proximal and distal stent edges associated with decreases in SNF and vasa vasorum formation, inflammatory cell infiltration, and Rho-kinase expression/activation. Furthermore, there were significant positive correlations between SNF and vasa vasorum and between SNF and coronary vasoconstricting responses. CONCLUSIONS: These results provide the first evidence that RDN ameliorates drug-eluting stent-induced coronary hyperconstricting responses in pigs in vivo through the kidney-brain-heart axis.
Long-term prognostic impact of the Great East Japan Earthquake in patients with cardiovascular disease - Report from the CHART-2 Study. 国際誌査読有り

Satoshi Miyata, Yasuhiko Sakata, Masanobu Miura, Takeshi Yamauchi, Takeo Onose, Kanako Tsuji, Ruri Abe, Takuya Oikawa, Shintaro Kasahara, Masayuki Sato, Kotaro Nochioka, Takashi Shiroto, Jun Takahashi, Hiroaki Shimokawa

Journal of cardiology　70　(3)　286-296　2017年9月

DOI： 10.1016/j.jjcc.2016.10.018 　

ISSN：0914-5087

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BACKGROUND: We and others have previously reported that the Great East Japan Earthquake (GEJE) caused a significant but transient increase in cardiovascular diseases and deaths in the disaster area. However, it remains to be examined whether the GEJE had a long-term prognostic influence in large-scale cohort studies. This point is important when analyzing the data before and after the GEJE in the cohort studies in the disaster area. METHODS: We examined 8676 patients registered in our Chronic Heart Failure Analysis and Registry in the Tohoku District-2 (CHART-2) Study (N=10,219) between 2006 and 2010 and were alive after March 10, 2011. RESULTS: There were 48 GEJE-related deaths, causing a sharp and transient increase in all-cause death within a month after the GEJE. However, after excluding the GEJE-related deaths, the cubic polynomial spline smoothing showed no significant increase in all-cause death, heart failure admission, non-fetal acute myocardial infarction, or non-fetal stroke during the median 3-year follow-up after the GEJE. The extrapolation curves beyond the GEJE, which were obtained by the parametric survival models based on the survival data censored on the GEJE, were not significantly different from the Kaplan-Meier curves estimating the survival functions of deaths and cardiac events during the total follow-up period without considering the impacts of the GEJE. Furthermore, the multivariate Cox proportional hazard model applied to the matched cohort of the baseline data and the data after the GEJE showed no significant differences in the impacts of prognostic factors on all-cause mortality before and after the GEJE. CONCLUSIONS: These results indicate that the GEJE had no significant long-term prognostic impact after the earthquake in cardiovascular patients in the disaster area.
Association of Coronary Perivascular Adipose Tissue Inflammation and Drug-Eluting Stent-Induced Coronary Hyperconstricting Responses in Pigs: 18F-Fluorodeoxyglucose Positron Emission Tomography Imaging Study. 国際誌査読有り

Kazuma Ohyama, Yasuharu Matsumoto, Hirokazu Amamizu, Hironori Uzuka, Kensuke Nishimiya, Susumu Morosawa, Michinori Hirano, Hiroshi Watabe, Yoshihito Funaki, Satoshi Miyata, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa

Arteriosclerosis, thrombosis, and vascular biology　37　(9)　1757-1764　2017年9月

DOI： 10.1161/ATVBAHA.117.309843 　

ISSN：1079-5642

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OBJECTIVE: Although coronary perivascular adipose tissue (PVAT) may play important roles as a source of inflammation, the association of coronary PVAT inflammation and coronary hyperconstricting responses remains to be examined. We addressed this important issue in a porcine model of coronary hyperconstricting responses after drug-eluting stent implantation with 18F-fluorodeoxyglucose (18F-FDG) positron emission tomographic imaging. APPROACH AND RESULTS: An everolimus-eluting stent (EES) was randomly implanted in pigs into the left anterior descending or the left circumflex coronary artery while nonstented coronary artery was used as a control. After 1 month, coronary vasoconstricting responses to intracoronary serotonin (10 and 100 μg/kg) were examined by coronary angiography in vivo, followed by in vivo and ex vivo 18F-FDG positron emission tomographic/computed tomographic imaging. Coronary vasoconstricting responses to serotonin were significantly enhanced at the EES edges compared with the control site (P<0.01; n=40). Notably, in vivo and ex vivo 18F-FDG positron emission tomographic/computed tomographic imaging and autoradiography showed enhanced 18F-FDG uptake and its accumulation in PVAT at the EES edges compared with the control site, respectively (both P<0.05). Furthermore, histological and reverse transcription polymerase chain reaction analysis showed that inflammatory changes of coronary PVAT were significantly enhanced at the EES edges compared with the control site (all P<0.01). Importantly, Rho-kinase expressions (ROCK1/ROCK2) and Rho-kinase activity (phosphorylated myosin phosphatase target subunit-1) at the EES edges were significantly enhanced compared with the control site. CONCLUSIONS: These results indicate for the first time that inflammatory changes of coronary PVAT are associated with drug-eluting stent-induced coronary hyperconstricting responses in pigs in vivo and that 18F-FDG positron emission tomographic imaging is useful for assessment of coronary PVAT inflammation.
Sex differences in post-traumatic stress disorder in cardiovascular patients after the Great East Japan Earthquake: a report from the CHART-2 Study. 国際誌査読有り

Takeo Onose, Yasuhiko Sakata, Kotaro Nochioka, Masanobu Miura, Takeshi Yamauchi, Kanako Tsuji, Ruri Abe, Takuya Oikawa, Shintaro Kasahara, Masayuki Sato, Takashi Shiroto, Satoshi Miyata, Jun Takahashi, Hiroaki Shimokawa

European heart journal. Quality of care & clinical outcomes　3　(3)　224-233　2017年7月1日

DOI： 10.1093/ehjqcco/qcx009 　

ISSN：2058-5225

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Aims: The temporal changes and sex differences in post-traumatic stress disorder (PTSD) after natural disasters remain unclear. Therefore, we examined the prevalence, prognostic impacts, and determinant factors of PTSD after the Great East Japan Earthquake (GEJE) of 11 March 2011 in cardiovascular (CV) patients registered in the Chronic Heart Failure Analysis and Registry in the Tohoku District (CHART)-2 Study (n = 10 219), with a special reference to sex. Methods and results: By self-completion questionnaires of the Japanese-language version of the Impact of Event Scale-Revised (IES-R-J), the prevalence of PTSD, defined as IES-R-J score ≥25, was 14.8, 15.7, 7.4, and 7.5% in 2011, 2012, 2013, and 2014, respectively. The PTSD rate was higher in women than in men in all years (all P < 0.01). During a median 3.5-year follow-up period, the patients with PTSD in 2011 more frequently experienced a composite of all-cause death and hospitalization for acute myocardial infarction, stroke, and heart failure than those without PTSD [adjusted hazard ratio (aHR) 1.27, P < 0.01]. Importantly, the prognostic impacts of PTSD on all-cause death (aHR 2.10 vs. 0.87, P for interaction = 0.03) and CV death (aHR 3.43 vs. 0.90, P for interaction = 0.02) were significant in women but not in men. While insomnia medication was a prominent determinant factor of PTSD in both sexes during 2011-14, economic poverty was significantly associated with PTSD only in men. Conclusion: After the GEJE, marked sex differences existed in the prevalence, prognostic impacts, and determinant factors of PTSD, suggesting the importance of sex-sepcific mental stress care in disaster medicine.
Reduced brain-derived neurotrophic factor is associated with cognitive dysfunction in patients with chronic heart failure. 査読有り

Hideaki Suzuki, Yasuharu Matsumoto, Hideki Ota, Koichiro Sugimura, Jun Takahashi, Kenta Ito, Satoshi Miyata, Hiroyuki Arai, Yasuyuki Taki, Katsutoshi Furukawa, Yoshihiro Fukumoto, Hiroaki Shimokawa

Geriatrics & gerontology international　17　(5)　852-854　2017年5月

DOI： 10.1111/ggi.12959 　

ISSN：1444-1586
Prognostic Impacts of Plasma Levels of Cyclophilin A in Patients With Coronary Artery Disease. 国際誌査読有り

Tomohiro Ohtsuki, Kimio Satoh, Junichi Omura, Nobuhiro Kikuchi, Taijyu Satoh, Ryo Kurosawa, Masamichi Nogi, Shinichiro Sunamura, Nobuhiro Yaoita, Tatsuo Aoki, Shunsuke Tatebe, Koichiro Sugimura, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

Arteriosclerosis, thrombosis, and vascular biology　37　(4)　685-693　2017年4月

DOI： 10.1161/ATVBAHA.116.308986 　

ISSN：1079-5642

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OBJECTIVE: Cyclophilin A (CyPA) is secreted from vascular smooth muscle cells, inflammatory cells, and activated platelets in response to oxidative stress. We have recently demonstrated that plasma CyPA level is a novel biomarker for diagnosing coronary artery disease. However, it remains to be elucidated whether plasma CyPA levels also have a prognostic impact in such patients. APPROACH AND RESULTS: In 511 consecutive patients undergoing diagnostic coronary angiography, we measured the plasma levels of CyPA, high-sensitivity C-reactive protein (hsCRP), and brain natriuretic peptide and evaluated their prognostic impacts during the follow-up (42 months, interquartile range: 25-55 months). Higher CyPA levels (≥12 ng/mL) were significantly associated with all-cause death, rehospitalization, and coronary revascularization. Higher hsCRP levels (≥1 mg/L) were also significantly correlated with the primary end point and all-cause death, but not with rehospitalization or coronary revascularization. Similarly, higher brain natriuretic peptide levels (≥100 pg/mL) were significantly associated with all-cause death and rehospitalization, but not with coronary revascularization. Importantly, the combination of CyPA (≥12 ng/mL) and hsCRP (≥1 mg/L) was more significantly associated with all-cause death (hazard ratio, 21.2; 95% confidence interval, 4.9-92.3,; P<0.001) than CyPA (≥12 ng/mL) or hsCRP (≥1 mg/L) alone. CONCLUSIONS: The results indicate that plasma CyPA levels can be used to predict all-cause death, rehospitalization, and coronary revascularization in patients with coronary artery disease and that when combined with other biomarkers (hsCRP and brain natriuretic peptide levels), the CyPA levels have further enhanced prognostic impacts in those patients.
Age-Specific Trends in the Incidence and In-Hospital Mortality of Acute Myocardial Infarction Over 30 Years in Japan - Report From the Miyagi AMI Registry Study. 査読有り

Yuanji Cui, Kiyotaka Hao, Jun Takahashi, Satoshi Miyata, Tomohiko Shindo, Kensuke Nishimiya, Yoku Kikuchi, Ryuji Tsuburaya, Yasuharu Matsumoto, Kenta Ito, Yasuhiko Sakata, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　81　(4)　520-528　2017年3月24日

DOI： 10.1253/circj.CJ-16-0799 　

ISSN：1346-9843

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BACKGROUND: We are now facing rapid population aging in Japan, which will affect the actual situation of cardiovascular diseases. However, age-specific trends in the incidence and mortality of acute myocardial infarction (AMI) in Japan remain to be elucidated.Methods and Results:We enrolled a total of 27,220 AMI patients (male/female 19,818/7,402) in our Miyagi AMI Registry during the past 30 years. We divided them into 4 age groups (≤59, 60-69, 70-79 and ≥80 years) and examined the temporal trends in the incidence and in-hospital mortality of AMI during 3 decades (1985-1994, 1995-2004 and 2005-2014). Throughout the entire period, the incidence of AMI steadily increased in the younger group (≤59 years in both sexes), while in the elderly groups (≥70 years in both sexes), the incidence significantly decreased during the last decade (all P<0.01). In-hospital cardiac mortality significantly decreased during the first 2 decades in elderly groups of both sexes (all P<0.01), whereas no further improvement was noted in the last decade irrespective of age or sex, despite improved critical care of AMI. CONCLUSIONS: These results provide the novel findings that the incidence of AMI has been increasing in younger populations and decreasing in the elderly, and that improvement in the in-hospital mortality of AMI may have reached a plateau in all age groups in Japan.
Japanese Acute Myocardial Infarction Registry(JAMIR)に登録された患者20126例の全国臨床現場データベース(Nationwide Real World Database of 20,126 Patients Enrolled in the Japanese Acute Myocardial Infarction Registry(JAMIR))

小島淳, 西平賢作, 竹上未紗, 中尾葉子, 本田怜史, 高橋潤, 高山守正, 木村一雄, 住吉徹哉, 安田聡

日本循環器学会学術集会抄録集　81回　LBCS5-1　2017年3月
出版者・発行元： (一社)日本循環器学会
観察研究における臨床ビッグデータの活用法 CHART-2研究からの教訓(How can We Utilize Clinical Big Data in an Observational Study? Lessons from the CHART-2 Study) 査読有り

白戸崇, 坂田泰彦, 山内毅, 小野瀬剛生, 辻薫菜子, 阿部瑠璃, 及川卓也, 笠原信太郎, 佐藤雅之, 三浦正暢, 後岡広太郎, 高橋潤, 宮田敏, 下川宏明

日本循環器学会学術集会抄録集　81回　PL08-5　2017年3月
出版者・発行元： (一社)日本循環器学会
HFpEF、境界型HFpEFおよびHFrEF患者に対するB型ナトリウム利尿ペプチドによる予後的リスク分類 CHART-2研究からの報告(Prognostic Risk Stratification with B-type Natriuretic Peptide for HFpEF, Borderline HFpEF and HFrEF Patients: A Report from the CHART-2 Study) 査読有り

笠原信太郎, 坂田泰彦, 後岡広太郎, 辻薫菜子, 小野瀬剛生, 阿部瑠璃, 及川卓也, 佐藤雅之, 白戸崇, 高橋潤, 宮田敏, 下川宏明

日本循環器学会学術集会抄録集　81回　OJ-014　2017年3月
出版者・発行元： (一社)日本循環器学会
虚血性心不全患者におけるstatin療法の強度と予後 CHART-2試験からの報告(Intensity of Statin Therapy and Prognosis in Patients with Ischemic Heart Failure: A Report from the CHART-2 Study) 査読有り

及川卓也, 坂田泰彦, 後岡広太郎, 辻薫菜子, 小野瀬剛生, 阿部瑠璃, 笠原信太郎, 佐藤雅之, 白戸崇, 高橋潤, 宮田敏, 下川宏明

日本循環器学会学術集会抄録集　81回　OJ-079　2017年3月
出版者・発行元： (一社)日本循環器学会
微小血管性狭心症患者におけるnitrate投与後も持続する心筋虚血(Sustained Myocardial Ischemia in Patients with Microvascular Angina Even after Nitrate Administration) 査読有り

小鷹悠二, 高橋潤, 羽尾清貴, 菊地翼, 須田彬, 小松真恭, 松本泰治, 伊藤健太, 宮田敏, 坂田泰彦, 下川宏明

日本循環器学会学術集会抄録集　81回　OJ-091　2017年3月
出版者・発行元： (一社)日本循環器学会
心血管疾患患者における抗血栓療法の経時的傾向 CHART-2研究からの報告(Temporal Trend in Antithrombotic Therapies in Patients with Cardiovascular Diseases: Report from the CHART-2 Study) 査読有り

白戸崇, 坂田泰彦, 後岡広太郎, 山内毅, 小野瀬剛生, 辻薫菜子, 阿部瑠璃, 及川卓也, 笠原信太郎, 佐藤雅之, 三浦正暢, 高橋潤, 宮田敏, 下川宏明

日本循環器学会学術集会抄録集　81回　LBCSP2-2　2017年3月
出版者・発行元： (一社)日本循環器学会
心不全患者における健康意識と死亡率との関連性 CHART-2試験からの報告(Association between Health Consciousness and Mortality in Patients with Heart Failure: A Report from the CHART-2 Study) 査読有り

阿部瑠璃, 坂田泰彦, 後岡広太郎, 小野瀬剛生, 辻薫菜子, 及川卓也, 笠原信太郎, 佐藤雅之, 三浦正暢, 白戸崇, 高橋潤, 宮田敏, 下川宏明

日本循環器学会学術集会抄録集　81回　PJ-219　2017年3月
出版者・発行元： (一社)日本循環器学会
Mid-range駆出率を示す心不全患者の臨床的特徴 CHART-2試験からの報告(Clinical Characteristics of Heart Failure Patients with Mid-range Ejection Fraction: A Report from the CHART-2 Study) 査読有り

辻薫菜子, 坂田泰彦, 後岡広太郎, 三浦正暢, 小野瀬剛生, 阿部瑠璃, 及川卓也, 笠原信太郎, 佐藤雅之, 白戸崇, 高橋潤, 宮田敏, 下川宏明

日本循環器学会学術集会抄録集　81回　PJ-278　2017年3月
出版者・発行元： (一社)日本循環器学会
日本の高齢急性心筋梗塞患者における救急治療の経時的な傾向と転帰(Temporal Trends in Emergency Care and Outcomes of Geriatric Patients with Acute Myocardial Infarction in Japan) 査読有り

崔元吉, 羽尾清貴, 高橋潤, 宮田敏, 進藤智彦, 菊地翼, 松本泰治, 伊藤健太, 坂田泰彦, 下川宏明

日本循環器学会学術集会抄録集　81回　PJ-290　2017年3月
出版者・発行元： (一社)日本循環器学会
血管攣縮性狭心症を有する院外心停止後生存者の長期予後更新情報(Long-term Prognosis of Out-of-hospital Cardiac Arrest Survivors with Vasospastic Angina: An Update) 査読有り

小松真恭, 高橋潤, 羽尾清貴, 菊地翼, 小鷹悠二, 須田彬, 松本泰治, 坂田泰彦, 宮田敏, 下川宏明

日本循環器学会学術集会抄録集　81回　PJ-673　2017年3月
出版者・発行元： (一社)日本循環器学会
Plasma concentration of serotonin is a novel biomarker for coronary microvascular dysfunction in patients with suspected angina and unobstructive coronary arteries. 国際誌査読有り

Yuji Odaka, Jun Takahashi, Ryuji Tsuburaya, Kensuke Nishimiya, Kiyotaka Hao, Yasuharu Matsumoto, Kenta Ito, Yasuhiko Sakata, Satoshi Miyata, Daisuke Manita, Yuji Hirowatari, Hiroaki Shimokawa

European heart journal　38　(7)　489-496　2017年2月14日

DOI： 10.1093/eurheartj/ehw448 　

ISSN：0195-668X

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Aims: Although the importance of coronary microvascular dysfunction (CMD) has been emerging, reliable biomarkers for CMD remain to be developed. We examined the potential usefulness of plasma concentration of serotonin to diagnose CMD in patients with suspected angina and unobstructive coronary arteries. Methods and results: We enrolled 198 consecutive patients (M/F 116/82, 60.2 ± 13.3 years old) who underwent acetylcholine provocation test and measured plasma serotonin concentration. Coronary microvascular dysfunction was defined as myocardial lactate production without or prior to the occurrence of epicardial coronary spasm during acetylcholine provocation test. Although no statistical difference in plasma concentration of serotonin [median (inter-quartile range) nmol/L] was noted between the vasospastic angina (VSA) and non-VSA groups [6.8 (3.8, 10.9) vs. 5.1 (3.7, 8.4), P = 0.135], it was significantly higher in patients with CMD compared with those without it [7.7 (4.5, 14.2) vs. 5.6 (3.7, 9.3), P = 0.008]. Among the four groups classified according to the presence or absence of VSA and CMD, serotonin concentration was highest in the VSA with CMD group. Importantly, there was a positive correlation between plasma serotonin concentration and baseline thrombolysis in myocardial infarction frame count (P = 0.001), a marker of coronary vascular resistance. The classification and regression trees analysis showed that plasma serotonin concentration of 9.55 nmol/L was the first discriminator to stratify the risk for the presence of CMD. In multivariable analysis, serotonin concentration greater than the cut-off value had the largest odds ratio in the prediction of CMD [odds ratio (95% confidence interval) 2.63 (1.28-5.49), P = 0.009]. Conclusions: Plasma concentration of serotonin may be a novel biomarker for CMD in patients with angina and unobstructive coronary arteries.
Prognostic Impact of Atrial Fibrillation and New Risk Score of Its Onset in Patients at High Risk of Heart Failure - A Report From the CHART-2 Study. 査読有り

Takeshi Yamauchi, Yasuhiko Sakata, Masanobu Miura, Takeo Onose, Kanako Tsuji, Ruri Abe, Takuya Oikawa, Shintaro Kasahara, Masayuki Sato, Kotaro Nochioka, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　81　(2)　185-194　2017年1月25日

DOI： 10.1253/circj.CJ-16-0759 　

ISSN：1346-9843

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BACKGROUND: The prognostic impact of atrial fibrillation (AF) among patients at high risk for heart failure (HF) remains unclear. In addition, there is no risk estimation model for AF development in these patients.Methods and Results:The present study included 5,382 consecutive patients at high risk of HF enrolled in the CHART-2 Study (n=10,219). At enrollment, 1,217 (22.6%) had AF, and were characterized, as compared with non-AF patients, by higher age, lower estimated glomerular filtration rate, higher B-type natriuretic peptide (BNP) level and lower left ventricular ejection fraction. A total of 116 non-AF patients (2.8%) newly developed AF (new AF) during the median 3.1-year follow-up. AF at enrollment was associated with worse prognosis for both all-cause death and HF hospitalization (adjusted hazard ratio (aHR) 1.31, P=0.027 and aHR 1.74, P=0.001, for all-cause death and HF hospitalization, respectively) and new AF was associated with HF hospitalization (aHR 4.54, P<0.001). We developed a risk score with higher age, smoking, pulse pressure, lower eGFR, higher BNP, aortic valvular regurgitation, LV hypertrophy, and left atrial and ventricular dilatation on echocardiography, which effectively stratified the risk of AF development with excellent accuracy (AUC 0.76). CONCLUSIONS: These results indicated that AF is associated with worse prognosis in patients at high risk of HF, and our new risk score may be useful to identify patients at high risk for AF onset.
東日本大震災と心血管病査読有り

青木竜男, 中野誠, 二瓶太郎, 羽尾清貴, 小野瀬剛生, 杉村宏一郎, 高橋潤, 福田浩二, 宮田敏, 坂田泰彦, 下川宏明

日本冠疾患学会雑誌　(Suppl.)　173-173　2016年12月
出版者・発行元： (NPO)日本冠疾患学会
ISSN：1341-7703

eISSN：2187-1949
Focal Vasa Vasorum Formation in Patients With Focal Coronary Vasospasm - An Optical Frequency Domain Imaging Study 査読有り

Kensuke Nishimiya, Yasuharu Matsumoto, Hironori Uzuka, Kazuma Ohyama, Kiyotaka Hao, Ryuji Tsuburaya, Takashi Shiroto, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa

CIRCULATION JOURNAL　80　(10)　2252-+　2016年10月

DOI： 10.1253/circj.CJ-16-0580 　

ISSN：1346-9843

eISSN：1347-4820
Influence of Left Ventricular Ejection Fraction on the Effects of Supplemental Use of Angiotensin Receptor Blocker Olmesartan in Hypertensive Patients With Heart Failure. 査読有り

Masanobu Miura, Yasuhiko Sakata, Satoshi Miyata, Nobuyuki Shiba, Jun Takahashi, Kotaro Nochioka, Tsuyoshi Takada, Chiharu Saga, Tsuyoshi Shinozaki, Masafumi Sugi, Makoto Nakagawa, Nobuyo Sekiguchi, Tatsuya Komaru, Atsushi Kato, Mitsumasa Fukuchi, Eiji Nozaki, Tetsuya Hiramoto, Kanichi Inoue, Toshikazu Goto, Masatoshi Ohe, Kenji Tamaki, Setsuro Ibayashi, Nobumasa Ishide, Yukio Maruyama, Ichiro Tsuji, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　80　(10)　2155-64　2016年9月23日

DOI： 10.1253/circj.CJ-16-0577 　

ISSN：1346-9843

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BACKGROUND: There is no robust evidence of pharmacological interventions to improve mortality in heart failure (HF) patients with preserved left ventricular ejection fraction (LVEF) (HFpEF). In this subanalysis study of the SUPPORT Trial, we addressed the influence of LVEF on the effects of olmesartan in HF. METHODS AND RESULTS: Among 1,147 patients enrolled in the SUPPORT Trial, we examined 429 patients with reduced LVEF (HFrEF, LVEF <50%) and 709 with HFpEF (LVEF ≥50%). During a median follow-up of 4.4 years, 21.9% and 12.5% patients died in the HFrEF and HFpEF groups, respectively. In HFrEF patients, the addition of olmesartan to the combination of angiotensin-converting enzyme inhibitor (ACEI) and β-blocker (BB) was associated with increased incidence of death (hazard ratio (HR) 2.26, P=0.002) and worsening renal function (HR 2.01, P=0.01), whereas its addition to ACEI or BB alone was not. In contrast, in HFpEF patients, the addition of olmesartan to BB alone was significantly associated with reduced mortality (HR 0.32, P=0.03), whereas with ACEIs alone or in combination with BB and ACEI was not. The linear mixed-effect model showed that in HFpEF, the urinary albumin/creatinine ratio was unaltered when BB were combined with olmesartan, but significantly increased when not combined with olmesartan (P=0.01). CONCLUSIONS: LVEF substantially influences the effects of additive use of olmesartan, with beneficial effects noted when combined with BB in hypertensive HFpEF patients. (Circ J 2016; 80: 2155-2164).
Beneficial effects of long-acting nifedipine on coronary vasomotion abnormalities after drug-eluting stent implantation: The NOVEL study. 国際誌査読有り

Ryuji Tsuburaya, Jun Takahashi, Akihiro Nakamura, Eiji Nozaki, Masafumi Sugi, Yoshito Yamamoto, Tetsuya Hiramoto, Satoru Horiguchi, Kanichi Inoue, Toshikazu Goto, Atsushi Kato, Tsuyoshi Shinozaki, Eiko Ishida, Satoshi Miyata, Satoshi Yasuda, Hiroaki Shimokawa

European heart journal　37　(35)　2713-21　2016年9月14日

DOI： 10.1093/eurheartj/ehw256 　

ISSN：0195-668X

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AIMS: It is widely known that drug-eluting stents (DES) induce coronary vasomotion abnormalities. We have previously demonstrated that chronic treatment with long-acting nifedipine suppresses coronary hyperconstricting responses induced by the first-generation DES (e.g. sirolimus- and pacritaxel-eluting stents) through inhibition of vascular inflammation in pigs. To examine whether this is also the case with the second-generation DES (everolimus-eluting stents, EES) in humans, the most widely used DES in the world, we conducted a prospective, randomized, multicentre trial, termed as the NOVEL Study. METHODS AND RESULTS: We evaluated 100 patients with stable angina pectoris who underwent scheduled implantation of EES in the left coronary arteries. They were randomly assigned to receive either conventional treatments alone or additionally long-acting nifedipine (10-60 mg/day) (n = 50 each). After 8-10 months, 37 patients in the control and 38 in the nifedipine group were examined for coronary vasoreactivity to intracoronary acetylcholine (ACh) by quantitative coronary angiography after 48-h withdrawal of nifedipine. Coronary vasoconstricting responses to ACh were significantly enhanced at the distal edge of EES compared with non-stented vessel (P = 0.0001) and were significantly suppressed in the nifedipine group compared with the control group (P = 0.0044). Furthermore, the inflammatory profiles were also improved only in the nifedipine group, which evaluated by serum levels of high-sensitivity CRP (P = 0.0001) and adiponectin (P = 0.0039). CONCLUSIONS: These results indicate that DES-induced coronary vasomotion abnormalities still remain an important clinical issue even with the second-generation DES, for which long-acting nifedipine exerts beneficial effects associated with its anti-inflammatory effects. TRIAL REGISTRATION: This study is registered at the UMIN Clinical Trial Registry (UMIN-CTR; ID=UMIN000015147).
第二次東北慢性心不全登録(CHART-2)研究の現状と展望査読有り

坂田泰彦, 三浦正暢, 但木壯一郎, 山内毅, 小野瀬剛生, 辻薫菜子, 阿部瑠璃, 及川卓也, 笠原信太郎, 高橋潤, 宮田敏, 下川宏明

日本心臓病学会学術集会抄録　64回　SS5-2　2016年9月
出版者・発行元： (一社)日本心臓病学会
東日本大震災から学んだこと査読有り

青木竜男, 中野誠, 二瓶太郎, 羽尾清貴, 小野瀬剛生, 杉村宏一郎, 高橋潤, 福田浩二, 宮田敏, 坂田泰彦, 下川宏明

日本心臓病学会学術集会抄録　64回　SS9-2　2016年9月
出版者・発行元： (一社)日本心臓病学会
心血管疾患患者における東日本大震災後の心的外傷後ストレス障害の経時変化と予後に及ぼす影響 CHART-2研究からの報告査読有り

小野瀬剛生, 坂田泰彦, 山内毅, 辻薫菜子, 及川卓也, 笠原信太郎, 高橋潤, 宮田敏, 下川宏明

日本心臓病学会学術集会抄録　64回　O-060　2016年9月
出版者・発行元： (一社)日本心臓病学会
HFpEF患者におけるBNP値と予後との関連はHFrEF患者と同等である査読有り

笠原信太郎, 坂田泰彦, 山内毅, 小野瀬剛生, 辻薫菜子, 阿部瑠璃, 及川卓也, 佐藤雅之, 高橋潤, 宮田敏, 下川宏明

日本心臓病学会学術集会抄録　64回　O-253　2016年9月
出版者・発行元： (一社)日本心臓病学会
心不全患者における東日本大震災後の心的外傷後ストレス障害が予後に及ぼす影響 CHART-2研究からの報告査読有り

小野瀬剛生, 坂田泰彦, 山内毅, 辻薫菜子, 及川卓也, 笠原信太郎, 高橋潤, 宮田敏, 下川宏明

日本心臓病学会学術集会抄録　64回　O-254　2016年9月
出版者・発行元： (一社)日本心臓病学会
慢性心不全患者の予後における左室駆出率と貧血の連関の影響の検討 CHART-2研究からの報告査読有り

山内毅, 坂田泰彦, 高田剛, 宮田敏, 三浦正暢, 但木壯一郎, 小野瀬剛生, 辻薫菜子, 阿部瑠璃, 及川卓也, 笠原信太郎, 後岡広太郎, 高橋潤, 下川宏明

日本心臓病学会学術集会抄録　64回　O-255　2016年9月
出版者・発行元： (一社)日本心臓病学会
慢性心不全患者における新しい予後予測リスクスコア査読有り

笠原信太郎, 坂田泰彦, 但木壯一郎, 山内毅, 小野瀬剛生, 辻薫菜子, 阿部瑠璃, 及川卓也, 高橋潤, 宮田敏, 下川宏明

日本心臓病学会学術集会抄録　64回　P-146　2016年9月
出版者・発行元： (一社)日本心臓病学会
心不全ハイリスク症例における心房細動の予後への影響と発症予測リスクスコアの検討 CHART-2研究からの報告査読有り

山内毅, 坂田泰彦, 白戸崇, 小野瀬剛生, 辻薫菜子, 阿部瑠璃, 及川卓也, 笠原信太郎, 佐藤雅之, 後岡広太郎, 高橋潤, 宮田敏, 下川宏明

日本心臓病学会学術集会抄録　64回　P-147　2016年9月
出版者・発行元： (一社)日本心臓病学会
スタチンの薬剤強度が心筋梗塞患者の予後に及ぼす影響の検討 CHART-2研究からの報告査読有り

及川卓也, 坂田泰彦, 三浦正暢, 但木壯一郎, 山内毅, 小野瀬剛生, 辻薫菜子, 笠原信太郎, 高橋潤, 宮田敏, 下川宏明

日本心臓病学会学術集会抄録　64回　P-148　2016年9月
出版者・発行元： (一社)日本心臓病学会
Usefulness of Testing for Coronary Artery Spasm and Programmed Ventricular Stimulation in Survivors of Out-of-Hospital Cardiac Arrest. 国際誌査読有り

Masayasu Komatsu, Jun Takahashi, Koji Fukuda, Yusuke Takagi, Takashi Shiroto, Makoto Nakano, Masateru Kondo, Ryuji Tsuburaya, Kiyotaka Hao, Kensuke Nishimiya, Taro Nihei, Yasuharu Matsumoto, Kenta Ito, Yasuhiko Sakata, Satoshi Miyata, Hiroaki Shimokawa

Circulation. Arrhythmia and electrophysiology　9　(9)　2016年9月

DOI： 10.1161/CIRCEP.115.003798 　

ISSN：1941-3149

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BACKGROUND: Optimal therapy for patients resuscitated from out-of-hospital cardiac arrest (OHCA) who are not found to have structural heart disease remains to be established, especially regarding the use of implantable cardioverter-defibrillators. Coronary artery spasm (CAS) and lethal ventricular arrhythmias are important causes of OHCA. METHODS AND RESULTS: In 47 consecutive OHCA survivors without structural heart disease who had fully recovered (M/F 44/3, 43±13 years.), we performed dual induction tests, including acetylcholine provocation test first followed by programmed ventricular stimulation after 1 to 2 weeks. Patients with CAS were treated with calcium channel blocker-based antianginal medications; implantable cardioverter-defibrillators were implanted in all patients. The results of the dual induction tests defined 4 groups: CAS alone (n=7), inducible ventricular arrhythmias alone (n=13), both positive (n=24), and both negative (n=3). During a median follow-up period of 38 months, ventricular fibrillation recurred in all groups except the both-negative group. Of the 16 patients with a type I Brugada ECG, 2 had CAS alone, 8 had ventricular arrhythmias alone, and 6 had both positive. No ventricular fibrillation episodes were observed in the CAS-alone patients who did not also have Brugada syndrome. Kaplan-Meier analysis showed that the CAS-alone group was at lower risk for OHCA recurrence as compared with the Brugada syndrome group (log-rank test; P=0.036). CONCLUSIONS: Among OHCA survivors without structural heart disease, provokable CAS and ventricular arrhythmias are common and can be seen in Brugada syndrome. CAS alone without Brugada syndrome who are treated for CAS may be a lower-risk group.
Overview of the 80th Annual Scientific Meeting of the Japanese Circulation Society - The Past, Present and Future of Cardiovascular Medicine in Japan - The 5th Anniversary of the Great East Japan Earthquake 査読有り

Jun Takahashi, Kimio Satoh, Koji Fukuda, Koichiro Sugimura, Yasuharu Matsumoto, Ryuji Tsuburaya, Tatsuo Aoki, Kensuke Nishimiya, Kenta Ito, Yasuhiko Sakata, Hiroaki Shimokawa

CIRCULATION JOURNAL　80　(8)　1689-1694　2016年8月

DOI： 10.1253/circj.CJ-16-0644 　

ISSN：1346-9843

eISSN：1347-4820
Hippocampal Blood Flow Abnormality Associated With Depressive Symptoms and Cognitive Impairment in Patients With Chronic Heart Failure. 査読有り

Hideaki Suzuki, Yasuharu Matsumoto, Hideki Ota, Koichiro Sugimura, Jun Takahashi, Kenta Ito, Satoshi Miyata, Katsutoshi Furukawa, Hiroyuki Arai, Yoshihiro Fukumoto, Yasuyuki Taki, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　80　(8)　1773-80　2016年7月25日

DOI： 10.1253/circj.CJ-16-0367 　

ISSN：1346-9843

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BACKGROUND: Depressive symptoms and memory impairment are prevalent in patients with chronic heart failure (CHF). Although the mechanisms remain to be elucidated, the hippocampus (an important brain area for emotion and memory) may be a possible neural substrate for these symptoms. METHODS AND RESULTS: We prospectively enrolled 40 Stage C patients, who had past or current CHF symptoms, and as controls 40 Stage B patients, who had structural heart disease but had never had CHF symptoms, in Brain Assessment and Investigation in Heart Failure Trial (B-HeFT) (UMIN000008584). As the primary index, we measured cerebral blood flow (CBF) in the 4 anterior-posterior segments of the hippocampus, using brain MRI analysis. Depressive symptoms, immediate memory (IM) and delayed memory (DM) were assessed using Geriatric Depression Scale (GDS), and Wechsler Memory Scale-revised (WMS-R), respectively. Hippocampus CBF in the most posterior segment was significantly lower in Stage C than in Stage B group (P=0.029 adjusted for Holm's method). Multiple regression analysis identified significant association between hippocampus CBF and GDS or DM score in Stage C group (all P<0.05). GDS score was significantly higher, and IM and DM scores were lower in Stage C patients with hippocampus CBF below the median than those with hippocampus CBF above the median (all P<0.05). CONCLUSIONS: Hippocampus abnormalities are associated with depressive symptoms and cognitive impairment in CHF patients. (Circ J 2016; 80: 1773-1780).
Increased Coronary Perivascular Adipose Tissue Volume in Patients With Vasospastic Angina 査読有り

Kazuma Ohyama, Yasuharu Matsumoto, Kensuke Nishimiya, Kiyotaka Hao, Ryuji Tsuburaya, Hideki Ota, Hirokazu Amamizu, Hironori Uzuka, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa

CIRCULATION JOURNAL　80　(7)　1653-+　2016年7月

DOI： 10.1253/circj.CJ-16-0213 　

ISSN：1346-9843

eISSN：1347-4820
There Is Much to Be Gained by Discarding Preconceived Notions 査読有り

Jun Takahashi

CIRCULATION JOURNAL　80　(7)　1532-1533　2016年7月

DOI： 10.1253/circj.CJ-16-0533 　

ISSN：1346-9843

eISSN：1347-4820
Prognostic Impact of Loop Diuretics in Patients With Chronic Heart Failure - Effects of Addition of Renin-Angiotensin-Aldosterone System Inhibitors and β-Blockers. 査読有り

Miura M, Sugimura K, Sakata Y, Miyata S, Tadaki S, Yamauchi T, Onose T, Tsuji K, Abe R, Oikawa T, Kasahara S, Nochioka K, Takahashi J, Shimokawa H, CHART, Investigators

Circulation journal : official journal of the Japanese Circulation Society　80　(6)　1396-403　2016年5月25日

DOI： 10.1253/circj.CJ-16-0216 　

ISSN：1346-9843
Enhanced Adventitial Vasa Vasorum Formation in Patients With Vasospastic Angina: Assessment With OFDI. 国際誌査読有り

Kensuke Nishimiya, Yasuharu Matsumoto, Jun Takahashi, Hironori Uzuka, Hongxin Wang, Ryuji Tsuburaya, Kiyotaka Hao, Kazuma Ohyama, Yuji Odaka, Satoshi Miyata, Kenta Ito, Hiroaki Shimokawa

Journal of the American College of Cardiology　67　(5)　598-600　2016年2月9日

DOI： 10.1016/j.jacc.2015.11.031 　

ISSN：0735-1097
震災と心血管病東日本大震災に関する検討から

青木竜男, 杉村宏一郎, 中野誠, 羽尾清貴, 二瓶太郎, 小野瀬剛生, 高橋潤, 福田浩二, 坂田泰彦, 下川宏明

Japanese Journal of Disaster Medicine　20　(3)　444-444　2016年2月
出版者・発行元： (一社)日本災害医学会
ISSN：2189-4035
Beneficial Effects of a Novel Bioabsorbable Polymer Coating on Enhanced Coronary Vasoconstricting Responses After Drug-Eluting Stent Implantation in Pigs in Vivo 査読有り

Kensuke Nishimiya, Yasuharu Matsumoto, Hironori Uzuka, Tsuyoshi Ogata, Michinori Hirano, Tomohiko Shindo, Yuhi Hasebe, Ryuji Tsuburaya, Takashi Shiroto, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa

JACC-CARDIOVASCULAR INTERVENTIONS　9　(3)　281-291　2016年2月

DOI： 10.1016/j.jcin.2015.09.041 　

ISSN：1936-8798

eISSN：1876-7605
虚血性心筋症の外科治療成績

川本俊輔, 高橋誠, 小田克彦, 熊谷紀一郎, 熊谷紀一郎, 秋山正年, 安達理, 増田信也, 藤原英記, 吉岡一朗, 河津聡, 片平晋太郎, 神田桂輔, 鈴木智之, 細山勝寛, 正木直樹, 高原真吾, 坂爪公, 渡邊晃佑, 齋木佳克, 齋木佳克

日本冠疾患学会雑誌　22　(2)　87-92　2016年
出版者・発行元： (NPO)日本冠疾患学会
DOI： 10.7793/jcoron.22.15-00026 　

ISSN：1341-7703

eISSN：2187-1949
サイクロフィリンAによる冠動脈疾患の長期予後予測査読有り

大槻知広, 佐藤公雄, 杉村宏一郎, 青木竜男, 建部俊介, 二瓶太郎, 高橋潤, 宮田敏, 下川宏明

血管　39　(1)　32-32　2016年1月
出版者・発行元：日本心脈管作動物質学会
ISSN：0911-4637
Prognostic Impact of New-Onset Atrial Fibrillation in Patients With Chronic Heart Failure - A Report From the CHART-2 Study. 査読有り

Takeshi Yamauchi, Yasuhiko Sakata, Masanobu Miura, Soichiro Tadaki, Ryoichi Ushigome, Kenjiro Sato, Takeo Onose, Kanako Tsuji, Ruri Abe, Takuya Oikawa, Shintaro Kasahara, Kotaro Nochioka, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　80　(1)　157-67　2016年

DOI： 10.1253/circj.CJ-15-0783 　

ISSN：1346-9843

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BACKGROUND: The prognostic impact of new-onset atrial fibrillation (AF) is not fully elucidated. METHODS AND RESULTS: We examined 4,818 consecutive stage C/D chronic heart failure (CHF) patients in the Chronic Heart Failure Analysis and Registry in the Tohoku District-2 (CHART-2) Study (n=10,219). At enrollment, 1,859 (38.6%) of them had AF. Compared with the 2,953 patients without AF, AF patients were characterized by higher age (71 vs. 68 years), lower estimated glomerular filtration rate (58.9 vs. 61.9 ml/min/1.73 m(2)), higher brain natriuretic peptide (152 vs. 74.5 pg/ml), similar left ventricular ejection fraction (56.8 vs. 56.5%), and a similar prescription rate of β-blockers (48.1 vs. 50.6%) and renin-angiotensin system (RAS) inhibitors (72.9 vs. 71.6%). Among the patients without AF at enrollment, 106 (3.6%) developed new AF during the median 3.2-year follow-up, which was associated with increased mortality (adjusted hazard ratio, 1.72; P=0.013). In contrast, neither paroxysmal nor chronic AF at enrollment was associated with increased mortality. The mortality rate was significantly high in the first year after the onset of new AF. On inverse probability of treatment weighting analysis using propensity score, RAS inhibitors and statins were associated with reduced incidence of new AF, and diuretics were associated with increase of new AF. CONCLUSIONS: Onset of new AF, but not a history of AF, is associated with increased mortality in CHF patients, especially in the first year.
Epic mitral生体弁の術後早期成績とその血行動態

神田桂輔, 古手川輝騎, 河津聡, 高橋悟朗, 吉岡一朗, 藤原英記, 安達理, 秋山正年, 熊谷紀一郎, 川本俊輔, 齋木佳克

胸部外科　68　(12)　961-966　2015年11月
出版者・発行元： (株)南江堂
ISSN：0021-5252

eISSN：2432-9436
心臓リハビリテーションからフレイルを考える経カテーテル大動脈弁留置術における心臓リハビリの役割フレイル(Frailty)の認識と呼吸・運動機能管理の重要性

松本泰治, 竹内雅史, 高橋潤, 杉村宏一郎, 三浦正暢, 上月正博, 下川宏明

日本心臓病学会学術集会抄録　63回　996-996　2015年9月
出版者・発行元： (一社)日本心臓病学会
我が国における高齢者心不全の臨床的特徴と予後規定因子第二次東北慢性心不全登録(CHART-2)研究からの報告査読有り

佐藤謙二郎, 坂田泰彦, 宮田敏, 三浦正暢, 牛込亮一, 但木壯一郎, 小野瀬剛生, 辻薫菜子, 山内毅, 阿部瑠璃, 後岡広太郎, 高橋潤, 下川宏明

日本心臓病学会学術集会抄録　63回　117-117　2015年9月
出版者・発行元： (一社)日本心臓病学会
新たなエビデンスに基づく震災時循環器疾患の予防と管理急性期から慢性期へ心血管疾患患者における東日本大震災後の心的外傷後ストレス障害とその予後に及ぼす影響 CHART-2研究からの報告査読有り

小野瀬剛生, 坂田泰彦, 後岡広太郎, 宮田敏, 三浦正暢, 但木壯一郎, 牛込亮一, 山内毅, 佐藤謙二郎, 辻薫菜子, 阿部瑠璃, 高橋潤, 下川宏明

日本心臓病学会学術集会抄録　63回　372-372　2015年9月
出版者・発行元： (一社)日本心臓病学会
心不全増悪をもたらす非心臓因子(脳、肺) 慢性心不全患者の予後に対する貧血の影響の検討 CHART-2研究からの報告査読有り

山内毅, 坂田泰彦, 高田剛, 宮田敏, 三浦正暢, 但木壮一郎, 牛込亮一, 佐藤謙二郎, 小野瀬剛生, 辻薫菜子, 阿部瑠璃, 後岡広太郎, 高橋潤, 下川宏明

日本心臓病学会学術集会抄録　63回　449-449　2015年9月
出版者・発行元： (一社)日本心臓病学会
疫学研究を循環器疾患予防に活かす我が国における慢性心不全大規模観察研究 CHART-2研究査読有り

坂田泰彦, 三浦正暢, 但木壮一郎, 牛込亮一, 佐藤謙二郎, 山内毅, 小野瀬剛生, 辻薫菜子, 阿部瑠璃, 後岡広太郎, 高橋潤, 宮田敏, 下川宏明

日本心臓病学会学術集会抄録　63回　457-457　2015年9月
出版者・発行元： (一社)日本心臓病学会
我が国の症候性慢性心不全診療の変遷と性差 CHART研究からの報告査読有り

牛込亮一, 坂田泰彦, 宮田敏, 三浦正暢, 但木壯一郎, 佐藤謙二郎, 山内毅, 小野瀬剛生, 辻薫菜子, 及川卓也, 笠原信太郎, 後岡広太郎, 高橋潤, 下川宏明

日本心臓病学会学術集会抄録　63回　545-545　2015年9月
出版者・発行元： (一社)日本心臓病学会
心疾患患者における糖尿病の管理虚血性/非虚血性心不全における糖尿病の予後への影響腎症の観点からの考察査読有り

三浦正暢, 坂田泰彦, 宮田敏, 但木壮一郎, 牛込亮一, 山内毅, 佐藤謙二郎, 小野瀬剛生, 辻薫菜子, 阿部瑠璃, 後岡広太郎, 高橋潤, 下川宏明

日本心臓病学会学術集会抄録　63回　1078-1078　2015年9月
出版者・発行元： (一社)日本心臓病学会
Association of Adventitial Vasa Vasorum and Inflammation With Coronary Hyperconstriction After Drug-Eluting Stent Implantation in Pigs In Vivo 査読有り

Kensuke Nishimiya, Yasuharu Matsumoto, Tomohiko Shindo, Kenichiro Hanawa, Yuhi Hasebe, Ryuji Tsuburaya, Takashi Shiroto, Jun Takahashi, Kenta Ito, Hatsue Ishibashi-Ueda, Satoshi Yasuda, Hiroaki Shimokawa

CIRCULATION JOURNAL　79　(8)　1787-U401　2015年8月

DOI： 10.1253/circj.CJ-15-0149 　

ISSN：1346-9843

eISSN：1347-4820
Clinical impacts of additive use of olmesartan in hypertensive patients with chronic heart failure: the supplemental benefit of an angiotensin receptor blocker in hypertensive patients with stable heart failure using olmesartan (SUPPORT) trial. 国際誌査読有り

Yasuhiko Sakata, Nobuyuki Shiba, Jun Takahashi, Satoshi Miyata, Kotaro Nochioka, Masanobu Miura, Tsuyoshi Takada, Chiharu Saga, Tsuyoshi Shinozaki, Masafumi Sugi, Makoto Nakagawa, Nobuyo Sekiguchi, Tatsuya Komaru, Atsushi Kato, Mitsumasa Fukuchi, Eiji Nozaki, Tetsuya Hiramoto, Kanichi Inoue, Toshikazu Goto, Masatoshi Ohe, Kenji Tamaki, Setsuro Ibayashi, Nobumasa Ishide, Yukio Maruyama, Ichiro Tsuji, Hiroaki Shimokawa

European heart journal　36　(15)　915-23　2015年4月14日

DOI： 10.1093/eurheartj/ehu504 　

ISSN：0195-668X

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We examined whether an additive treatment with an angiotensin receptor blocker, olmesartan, reduces the mortality and morbidity in hypertensive patients with chronic heart failure (CHF) treated with angiotensin-converting enzyme (ACE) inhibitors, β-blockers, or both. In this prospective, randomized, open-label, blinded endpoint study, a total of 1147 hypertensive patients with symptomatic CHF (mean age 66 years, 75% male) were randomized to the addition of olmesartan (n = 578) to baseline therapy vs. control (n = 569). The primary endpoint was a composite of all-cause death, non-fatal acute myocardial infarction, non-fatal stroke, and hospitalization for worsening heart failure. During a median follow-up of 4.4 years, the primary endpoint occurred in 192 patients (33.2%) in the olmesartan group and in 166 patients (29.2%) in the control group [hazard ratio (HR) 1.18; 95% confidence interval (CI), 0.96-1.46, P = 0.112], while renal dysfunction developed more frequently in the olmesartan group (16.8 vs. 10.7%, HR 1.64; 95% CI 1.19-2.26, P = 0.003). Subgroup analysis revealed that addition of olmesartan to combination of ACE inhibitors and β-blockers was associated with increased incidence of the primary endpoint (38.1 vs. 28.2%, HR 1.47; 95% CI 1.11-1.95, P = 0.006), all-cause death (19.4 vs. 13.5%, HR 1.50; 95% CI 1.01-2.23, P = 0.046), and renal dysfunction (21.1 vs. 12.5%, HR 1.85; 95% CI 1.24-2.76, P = 0.003). Additive use of olmesartan did not improve clinical outcomes but worsened renal function in hypertensive CHF patients treated with evidence-based medications. Particularly, the triple combination therapy with olmesartan, ACE inhibitors and β-blockers was associated with increased adverse cardiac events. This study is registered at clinicaltrials.gov-NCT00417222.
Prognostic impact of chronic nitrate therapy in patients with vasospastic angina: multicentre registry study of the Japanese coronary spasm association. 国際誌査読有り

Jun Takahashi, Taro Nihei, Yusuke Takagi, Satoshi Miyata, Yuji Odaka, Ryusuke Tsunoda, Atsushi Seki, Tetsuya Sumiyoshi, Motoyuki Matsui, Toshikazu Goto, Yasuhiko Tanabe, Shozo Sueda, Shin-ichi Momomura, Satoshi Yasuda, Hisao Ogawa, Hiroaki Shimokawa

European heart journal　36　(4)　228-37　2015年1月21日

DOI： 10.1093/eurheartj/ehu313 　

ISSN：0195-668X

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AIMS: Although nitrates are widely used as a concomitant therapy with calcium channel blockers (CCBs) for vasospastic angina (VSA), their prognostic contribution remains unclear. The present study aimed to examine the prognostic impact of chronic nitrate therapy in patients with VSA. METHODS AND RESULTS: A total of 1429 VSA patients (median 66 years; male/female, 1090/339) were enrolled. The primary endpoint was defined as major adverse cardiac events (MACE). The propensity score matching and multivariable Cox proportional hazard model were used to adjust for selection bias for treatment and potential confounding factors. Among the study patients, 695 (49%) were treated with nitrates, including conventional nitrates [e.g. nitroglycerin (GTN), isosorbide mono- and dinitrate] in 551 and nicorandil in 306. Calcium channel blockers were used in >90% of patients. During the median follow-up period of 32 months, 85 patients (5.9%) reached the primary endpoint. Propensity score-matched analysis demonstrated that the cumulative incidence of MACE was comparable between the patients with and those without nitrates [11 vs. 8% at 5 years; hazard ratio (HR): 1.28; 95% confidence interval (CI): 0.72-2.28, P = 0.40]. Although nicorandil itself had a neutral prognostic effect on VSA (HR: 0.80; 95% CI: 0.28-2.27, P = 0.67), multivariable Cox model revealed the potential harm of concomitant use of conventional nitrates and nicorandil (HR: 2.14; 95% CI: 1.02-4.47; P = 0.044), particularly when GTN and nicorandil were simultaneously administered. CONCLUSIONS: Chronic nitrate therapy did not improve the long-term prognosis of VSA patients when combined with CCBs. Furthermore, the VSA patients with multiple nitrates would have increased risk for cardiac events.
宮城県心筋梗塞対策協議会

高橋潤, 下川宏明

日本冠疾患学会雑誌　21　(2)　127-131　2015年
出版者・発行元： The Japanese Coronary Association
DOI： 10.7793/jcoron.21.014 　

ISSN：1341-7703
胸部大動脈瘤術後の大動脈径変化へのカンデサルタンによる影響:CAPTAIN study中間報告

片平晋太郎, 熊谷紀一郎, 佐々木康ノ輔, 鈴木満里奈, 川本俊輔, 齋木佳克, 大田英揮, 高瀬圭, 菅原由美, 辻一郎, 永谷公一, 長嶺進, 三浦誠, 高橋悟朗, 篠崎滋

日本心臓血管外科学会雑誌　44　(Supplement)　341-341　2015年
出版者・発行元： (NPO)日本心臓血管外科学会
ISSN：0285-1474

eISSN：1883-4108
Prognostic impact of statin use in patients with heart failure and preserved ejection fraction. 査読有り

Kotaro Nochioka, Yasuhiko Sakata, Satoshi Miyata, Masanobu Miura, Tsuyoshi Takada, Soichiro Tadaki, Ryoichi Ushigome, Takeshi Yamauchi, Jun Takahashi, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　79　(3)　574-82　2015年

DOI： 10.1253/circj.CJ-14-0865 　

ISSN：1346-9843

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BACKGROUND: The effectiveness of statins remains to be examined in patients with heart failure (HF) with preserved ejection fraction (EF). METHODS AND RESULTS: Among 4,544 consecutive HF patients registered in the Chronic Heart Failure Registry and Analysis in the Tohoku district-2 (CHART-2) between 2006 and 2010, 3,124 had EF ≥50% (HFpEF; mean age 69 years; male 65%) and 1,420 had EF <50% (HF with reduced EF (HFrEF); mean age 67 years; male 75%). The median follow-up was 3.4 years. The 3-year mortality in HFpEF patients was lower in patients receiving statins [8.7% vs. 14.5%, adjusted hazard ratio (HR) 0.74; 95% confidence interval (CI), 0.58-0.94; P<0.001], which was confirmed in the propensity score-matched cohort (HR, 0.72; 95% CI, 0.49-0.99; P=0.044). The inverse probability of treatment weighted further confirmed that statin use was associated with reduced incidence of all-cause death (HR, 0.71; 95% CI, 0.62-0.82, P<0.001) and noncardiovascular death (HR, 0.53; 95% CI, 0.43-0.66, P<0.001), specifically reduction of sudden death (HR, 0.59; 95% CI, 0.36-0.98, P=0.041) and infection death (HR, 0.53; 95% CI, 0.35-0.77, P=0.001) in HFpEF. In the HFrEF cohort, statin use was not associated with mortality (HR, 0.87; 95% CI, 0.73-1.04, P=0.12), suggesting a lack of statin benefit in HFrEF patients. CONCLUSIONS: These results suggest that statin use is associated with improved mortality rates in HFpEF patients, mainly attributable to reductions in sudden death and noncardiovascular death.
Predictors and prognostic impact of post-traumatic stress disorder after the great East Japan earthquake in patients with cardiovascular disease. 査読有り

Takeo Onose, Kotaro Nochioka, Yasuhiko Sakata, Masanobu Miura, Soichiro Tadaki, Ryoichi Ushigome, Takeshi Yamauchi, Kenjiro Sato, Kanako Tsuji, Ruri Abe, Satoshi Miyata, Jun Takahashi, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　79　(3)　664-7　2015年

DOI： 10.1253/circj.CJ-14-1403 　

ISSN：1346-9843

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BACKGROUND: We examined the prevalence, predictors and prognostic impact of post-traumatic stress disorder (PTSD) after the Great East Japan Earthquake in patients with cardiovascular disease (CVD) in the CHART-2 study. METHODS AND RESULTS: The prevalence of PTSD was 14.7% at 6 months after the Earthquake. Female sex, experiencing the Tsunami, property loss, poverty, and insomnia medication use were associated with PTSD. The patients with PTSD more frequently experienced a composite of death, acute myocardial infarction, stroke and heart failure (18.5% vs. 15.0%, P=0.035). CONCLUSIONS: PTSD was frequent in CVD patients after the Earthquake and had an adverse prognostic impact.
Improved Long-Term Prognosis of Dilated Cardiomyopathy With Implementation of Evidenced-Based Medication - Report From the CHART Studies - . 査読有り

Ryoichi Ushigome, Yasuhiko Sakata, Kotaro Nochioka, Satoshi Miyata, Masanobu Miura, Soichiro Tadaki, Takeshi Yamauchi, Kenjiro Sato, Takeo Onose, Kanako Tsuji, Ruri Abe, Jun Takahashi, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　79　(6)　1332-41　2015年

DOI： 10.1253/circj.CJ-14-0939 　

ISSN：1346-9843

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BACKGROUND: Recent trends in the clinical characteristics, management and prognosis of dilated cardiomyopathy (DCM) remain to be examined in Japan. METHODS AND RESULTS: We compared 306 and 710 DCM patients in the Chronic Heart Failure Analysis and Registry in the Tohoku District (CHART)-1 (2000-2005, n=1,278) and the CHART-2 (2006-present, n=10,219) Studies, respectively. Between the 2 groups of DCM patients, there were no significant differences in baseline characteristics. The prevalence of hypertension, dyslipidemia and diabetes mellitus were all significantly increased from the CHART-1 to the CHART-2 Study. The use of β-blockers and aldosterone antagonists was significantly increased, while that of loop diuretics and digitalis was significantly decreased in the CHART-2 Study. The 3-year mortality rate was significantly improved from 14% in the CHART-1 to 9% in the CHART-2 Study (adjusted HR, 0.60; 95% CI: 0.49-0.81; P=0.001). In particular, 3-year incidence of cardiovascular death was significantly decreased (adjusted HR, 0.26; 95% CI: 0.14-0.50, P<0.001), while that of HF admission was not (adjusted HR, 0.90; 95% CI: 0.59-1.37, P=0.632). The prognostic improvement was noted in patients with BNP <220 pg/ml, LVEF>40%, β-blocker use and aldosterone antagonist use. CONCLUSIONS: Long-term prognosis of DCM patients has been improved, along with the implementation of evidence-based medication in Japan.
Accuracy of optical frequency domain imaging for evaluation of coronary adventitial vasa vasorum formation after stent implantation in pigs and humans - a validation study - . 査読有り

Kensuke Nishimiya, Yasuharu Matsumoto, Hironori Uzuka, Kazuma Oyama, Atsushi Tanaka, Akira Taruya, Tsuyoshi Ogata, Michinori Hirano, Tomohiko Shindo, Kenichiro Hanawa, Yuhi Hasebe, Kiyotaka Hao, Ryuji Tsuburaya, Jun Takahashi, Satoshi Miyata, Kenta Ito, Takashi Akasaka, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　79　(6)　1323-31　2015年

DOI： 10.1253/circj.CJ-15-0078 　

ISSN：1346-9843

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BACKGROUND: Coronary adventitia harbors a wide variety of components, such as inflammatory cells and vasa vasorum (VV). Adventitial VV initiates the development of coronary artery diseases as an outside-in supply route of inflammation. We have recently demonstrated that drug-eluting stent implantation causes the enhancement of VV formation, with extending to the stent edges in the porcine coronary arteries, and also that optical frequency domain imaging (OFDI) is capable of visualizing VV in humans in vivo. However, it remains to be fully validated whether OFDI enables the precise measurement of VV formation in pigs and humans. METHODS AND RESULTS: In the pig protocol, a total of 6 bare-metal stents and 12 drug-eluting stents were implanted into the coronary arteries, and at 1 month, the stented coronary arteries were imaged by OFDI ex vivo. OFDI data including the measurement of VV area at the stent edge portions were compared with histological data. There was a significant positive correlation between VV area on OFDI and that on histology (R=0.91, P<0.01). In the human protocol, OFDI enabled the measurement of the VV area at the stent edges after coronary stent implantation in vivo. CONCLUSIONS: These results provide the first direct evidence that OFDI enables the precise measurement of the VV area in coronary arteries after stent implantation in pigs and humans.
Comprehensive Risk Stratification of Japanese Patients With Aortic Stenosis--A Proposal of a New Risk Score From the CHART-2 Study. 査読有り

Kenjiro Sato, Yasuhiko Sakata, Masanobu Miura, Soichiro Tadaki, Ryoichi Ushigome, Takeshi Yamauchi, Takeo Onose, Kanako Tsuji, Ruri Abe, Kotaro Nochioka, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　79　(7)　1631-8　2015年

DOI： 10.1253/circj.CJ-15-0062 　

ISSN：1346-9843

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BACKGROUND: The risk of patients with aortic stenosis (AS) should be stratified not only by AS severity but also by comorbidities. METHODS AND RESULTS: We aimed to develop a risk score for mortality in 412 patients with AS (pressure gradient ≥30 mmHg, mean age 74.9 years, male 52.4%) in the CHART-2 Study (n=10,219). During a 3-year follow-up, 73 (17.7%) patients died. Crude 3-year mortality of patients in New York Heart Association (NYHA) classes I, II, and III/IV was 9.5%, 16.5%, and 49.7%, respectively (P<0.001). Stepwise Cox regression analysis showed that the combination of 7 factors was the best model to predict the mortality of AS patients, who were scored according to their hazard ratios, including NYHA class III-IV (score 6), male sex (3), serum albumin level ≤4 g/dl (2), aortic peak flow ≥4.5 m/s (2), age ≥75 years (2), chronic kidney disease (2), and anemia (1). Receiver-operating characteristic analysis showed excellent association between the sum of the scores and 3-year mortality (area under the curve, 0.78). The multivariate Cox proportional hazard model demonstrated that the present risk score also well stratified the mortality risk. CONCLUSIONS: The present study demonstrates that, in addition to the classical prognostic factors related to symptoms and AS severity, various comorbidities are associated with mortality. Thus, the present comprehensive risk score may be useful for risk stratification of AS patients.
Prognostic Impact of Diabetes Mellitus in Chronic Heart Failure According to Presence of Ischemic Heart Disease – With Special Reference to Nephropathy. 査読有り

Miura M, Sakata Y, Miyata S, Nochioka K, Takada T, Tadaki S, Ushigome R, Yamauchi T, Sato K, Onose T, Tsuji K, Abe R, Takahashi J, Shimokawa H, CHART, Investigators

Circulation journal : official journal of the Japanese Circulation Society　79　(8)　1764-72　2015年

DOI： 10.1253/circj.CJ-15-0096 　

ISSN：1346-9843
Prognostic Impact of Anemia in Patients With Chronic Heart Failure- With Special Reference to Clinical Background: Report From the CHART-2 Study. 査読有り

Takeshi Yamauchi, Yasuhiko Sakata, Tsuyoshi Takada, Kotaro Nochioka, Masanobu Miura, Soichiro Tadaki, Ryoichi Ushigome, Kenjiro Sato, Takeo Onose, Kanako Tsuji, Ruri Abe, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　79　(9)　1984-93　2015年

DOI： 10.1253/circj.CJ-15-0174 　

ISSN：1346-9843

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BACKGROUND: We aimed to elucidate the prognostic impact of anemia with special reference to the clinical background of patients with chronic heart failure (CHF). METHODS AND RESULTS: We examined 4,646 consecutive patients with Stage C/D CHF registered in the Chronic Heart Failure Analysis and Registry in the Tohoku District-2 (CHART-2) Study (n=10,219). Among them, 1,627 (35%) had anemia and were characterized by higher age (74 vs. 66 years), lower estimated glomerular filtration rate (52.8 vs. 66.1 ml/min/1.73 m(2)) and higher B-type natriuretic peptide levels (154.5 vs. 81.8 pg/ml) (all P<0.001) but comparable left ventricular ejection fraction (LVEF; 57.5 vs. 56.7%). Anemic patients were more frequently treated with diuretics (55.1 vs. 42.3%) but less often treated with β-blockers (45.4 vs. 51.1%) (both P<0.001). During a median follow-up of 3.8 years, 371 and 272 patients died with and without anemia, respectively (22.8 vs. 9.0%, adjusted hazard ratio 1.40; 95% confidence interval 1.15-1.71, P=0.001). Subgroup analysis revealed that the prognostic impact of anemia was comparable in terms of age, sex, renal function and double product, but differed by LVEF level and CHF etiology (both, P for interaction <0.001). In particular, a difference in the prognostic impact of LVEF level was noted in patients with ischemic heart disease. CONCLUSIONS: These results indicate that the prognostic impact of anemia is evident in CHF patients with preserved EF and it differs by CHF etiology.
Clinical Characteristics of Patients With Acute Myocardial Infarction Who Did Not Undergo Primary Percutaneous Coronary Intervention- Report From the MIYAGI-AMI Registry Study. 査読有り

Kiyotaka Hao, Jun Takahashi, Kenta Ito, Satoshi Miyata, Taro Nihei, Kensuke Nishimiya, Ryuji Tsuburaya, Yasuharu Matsumoto, Yasuhiko Sakata, Satoshi Yasuda, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　79　(9)　2009-16　2015年

DOI： 10.1253/circj.CJ-15-0440 　

ISSN：1346-9843

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BACKGROUND: In the current era of primary percutaneous coronary intervention (PCI), some patients with acute myocardial infarction (AMI) still do not undergo primary PCI. METHODS AND RESULTS: To examine the clinical characteristics of AMI patients who did not undergo primary PCI, we analyzed patients enrolled between 2002 and 2010 in the MIYAGI-AMI Registry Study, in which all AMI patients in the Miyagi prefecture have been prospectively registered. Among a total of 8,640 patients, 1,879 (21.7%) did not undergo primary PCI and their in-hospital mortality was significantly worse compared with those who did (21.4% vs. 6.4%, P<0.01). Multivariate analysis demonstrated that female sex was significantly associated with non-performance of primary PCI [odds ratio (95% confidence interval): 1.40 (1.22-1.61), P<0.001], along with age [1.01 (1.01-1.02), P<0.001] and heart failure on admission [2.69 (2.29-3.16), P<0.001]. When dividing by age, the non-performance rate of primary PCI in females showed a U-shaped prevalence, whereas it simply increased with aging in males. Importantly, female patients aged <80 years had a significantly higher non-performance rate of primary PCI compared with male patients, regardless of the severity of AMI. CONCLUSIONS: These results indicate that in the current PCI era, various factors, including aging, heart failure on admission and sex differences, are associated with non-performance of primary PCI, which remain to be resolved in order to further improve critical care of AMI.
Temporal trends in clinical characteristics, management and prognosis of patients with symptomatic heart failure in Japan -- report from the CHART Studies. 査読有り

Ryoichi Ushigome, Yasuhiko Sakata, Kotaro Nochioka, Satoshi Miyata, Masanobu Miura, Soichiro Tadaki, Takeshi Yamauchi, Kenjiro Sato, Takeo Onose, Kanako Tsuji, Ruri Abe, Takuya Oikawa, Shintaro Kasahara, Jun Takahashi, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　79　(11)　2396-407　2015年

DOI： 10.1253/circj.CJ-15-0514 　

ISSN：1346-9843

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BACKGROUND: Temporal trends in clinical characteristics, management and prognosis of patients with symptomatic heart failure (HF) remain to be elucidated in Japan. METHODS AND RESULTS: From the Chronic Heart Failure Analysis and Registry in the Tohoku District-1 (CHART-1; 2000-2005, n=1,278) and CHART-2 (2006-present, n=10,219) Studies, we enrolled 1,006 and 3,676 consecutive symptomatic stage C/D HF patients, respectively. As compared with the patients in the CHART-1 Study, those in the CHART-2 Study had similar age and sex prevalence, and were characterized by lower brain natriuretic peptide, higher prevalence of preserved left ventricular ejection fraction (LVEF) and higher prevalence of hypertension, diabetes mellitus and ischemic heart disease (IHD), particularly IHD with LVEF ≥50%. From CHART-1 to CHART-2, use of renin-angiotensin system inhibitors, β-blockers and aldosterone antagonists was significantly increased, while that of loop diuretics and digitalis was decreased. Three-year incidences of all-cause death (24 vs. 15%; adjusted hazard ratio [adjHR], 0.73; P<0.001), cardiovascular death (17 vs. 7%; adjHR, 0.38; P<0.001) and hospitalization for HF (30 vs. 17%; adjHR, 0.51; P<0.001) were all significantly decreased from CHART-1 to CHART-2. In the CHART-2 Study, use of β-blockers was associated with improved prognosis in patients with LVEF <50%, while that of statins was associated with improved prognosis in those with LVEF ≥50%. CONCLUSIONS: Along with implementation of evidence-based medications, the prognosis of HF patients has been improved in Japan. ( TRIAL REGISTRATION: clinicaltrials.gov identifier: NCT00418041)
Factors influencing the occurrence of cardiopulmonary arrest in the Great East Japan Earthquake disaster. 国際誌査読有り

Kiyotaka Hao, Jun Takahashi, Tatsuo Aoki, Satoshi Miyata, Kenta Ito, Yasuhiko Sakata, Hiroaki Shimokawa

International journal of cardiology　177　(2)　569-72　2014年12月15日

DOI： 10.1016/j.ijcard.2014.08.127 　

ISSN：0167-5273
Prognostic Impact of Subclinical Microalbuminuria in Patients With Chronic Heart Failure. 査読有り

Masanobu Miura, Yasuhiko Sakata, Satoshi Miyata, Kotaro Nochioka, Tsuyoshi Takada, Soichiro Tadaki, Ryoichi Ushigome, Takeshi Yamauchi, Jun Takahashi, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　2014年10月30日

DOI： 10.1253/circj.CJ-14-0787 　

ISSN：1346-9843

eISSN：1347-4820

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Background:Microalbuminuria, traditionally defined as urinary albumin/creatinine ratio (UACR) ≥30 mg/g, is a risk factor for mortality even in patients with preserved glomerular filtration rate (GFR). The prognostic impact of subclinical microalbuminuria, however, remains unknown in patients with chronic heart failure (CHF).Methods and Results:In the Chronic Heart Failure Analysis and Registry in the Tohoku District 2 Study, we enrolled 2,039 consecutive symptomatic CHF patients (median age, 67.4 years; 68.9% male) after excluding those on hemodialysis. On classification and regression tree analysis, UACR=10.2 mg/g and 27.4 mg/g were identified as the first and second discriminating points to stratify the risk for composite of death, acute myocardial infarction, HF admission and stroke, therefore subclinical microalbuminuria was defined as UACR ≥10.2 and <27.4 mg/g. There were 506 composite endpoints (24.8%) during the median follow-up of 2.69 years. On Kaplan-Meier analysis and multivariate Cox modeling, subclinical microalbuminuria was significantly associated with increased composite endpoints with hazard ratios of 1.90 (P<0.001) and 2.29 (P<0.001) in patients with preserved (>60 ml·min-1·1.73 m-2, n=1,129) or mildly reduced eGFR (30-59.9 ml·min-1·1.73 m-2, n=789), respectively. In patients with severely reduced GFR (eGFR <30 ml·min-1·1.73 m-2, n=121), >80% had microalbuminuria or macroalbuminuria, and only 9.1% were free from any composite endpoints.Conclusions:Subclinical microalbuminuria was associated with increased risk of cardiovascular events in CHF patients with mildly reduced or preserved renal function.
In Vivo Visualization of Adventitial Vasa Vasorum of the Human Coronary Artery on Optical Frequency Domain Imaging - Validation Study 査読有り

Kensuke Nishimiya, Yasuharu Matsumoto, Jun Takahashi, Hironori Uzuka, Yuji Odaka, Taro Nihei, Kiyotaka Hao, Ryuji Tsuburaya, Kenta Ito, Hiroaki Shimokawa

CIRCULATION JOURNAL　78　(10)　2516-2518　2014年10月

DOI： 10.1253/circj.CJ-14-0485 　

ISSN：1346-9843

eISSN：1347-4820
日本の臨床研究の現状と展望東北慢性心不全登録(CHART-2)研究の現状と展望査読有り

坂田泰彦, 宮田敏, 後岡広太郎, 三浦正暢, 但木壮一郎, 牛込亮一, 山内毅, 高橋潤, 下川宏明

日本心臓病学会学術集会抄録　62回　SS-4　2014年9月
出版者・発行元： (一社)日本心臓病学会
心不全患者に対する多面的アプローチ症例背景を考慮した心不全へのアプローチ CHART-2研究の知見から査読有り

坂田泰彦, 宮田敏, 後岡広太郎, 三浦正暢, 高田剛史, 但木壮一郎, 牛込亮一, 山内毅, 高橋潤, 下川宏明

日本心臓病学会学術集会抄録　62回　S12-1　2014年9月
出版者・発行元： (一社)日本心臓病学会
慢性疾患・生活習慣病を合併した心疾患患者の管理虚血性/非虚血性心不全における糖尿病の予後に及ぼす影響に関する検討 CHART-2研究からの報告査読有り

三浦正暢, 坂田泰彦, 宮田敏, 後岡広太郎, 高田剛史, 但木壮一郎, 牛込亮一, 山内毅, 高橋潤, 下川宏明

日本心臓病学会学術集会抄録　62回　S17-1　2014年9月
出版者・発行元： (一社)日本心臓病学会
Development of non-invasive regenerative therapy for cardiovascular diseases: Low-energy extracorporeal shock wave therapy 査読有り

Kenta Ito, Tomohiko Shindo, Tsuyoshi Ogata, Kazuaki Hatanaka, Fukashi Serizawa, Keiichiro Kawamura, Jun Takahashi, Yasuharu Matsumoto, Ryuji Tsuburaya, Kiyotaka Hao, Kensuke Nishimiya, Taro Nihei, Yuji Odaka, Kenichiro Hanawa, Yuhi Hasebe, Hironori Uzuka, Michinori Hirano, Hitoshi Goto, Hiroaki Shimokawa

Transactions of Japanese Society for Medical and Biological Engineering　52　68-O-69　2014年8月17日
出版者・発行元： Japan Soc. of Med. Electronics and Biol. Engineering
DOI： 10.11239/jsmbe.52.O-68 　

ISSN：1347-443X 1881-4379

eISSN：1347-443X
Impact of the Adjusted Dosing Regimen of Prasugrel for Japanese Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention 査読有り

Jun Takahashi

CIRCULATION JOURNAL　78　(7)　1577-1578　2014年7月

DOI： 10.1253/circj.CJ-14-0572 　

ISSN：1346-9843

eISSN：1347-4820
REVIEW & PREVIEW 大災害と心血管病査読有り

高橋潤, 下川, 宏

Medicina　51　(6)　1159-1163　2014年6月
Impact of elevated heart rate on clinical outcomes in patients with heart failure with reduced and preserved ejection fraction: a report from the CHART-2 Study. 国際誌査読有り

Tsuyoshi Takada, Yasuhiko Sakata, Satoshi Miyata, Jun Takahashi, Kotaro Nochioka, Masanobu Miura, Soichiro Tadaki, Hiroaki Shimokawa

European journal of heart failure　16　(3)　309-16　2014年3月

DOI： 10.1002/ejhf.22 　

ISSN：1388-9842

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AIMS: It is still controversial whether elevated baseline heart rate (HR) is associated with higher mortality in patients with heart failure (HF) with preserved ejection fraction (HFpEF). We compared the impacts of baseline HR on mortality in patients with HFpEF and those with HF with reduced ejection fraction (HFrEF). METHODS AND RESULTS: We enrolled consecutive 2688 patients in Stage C or D HF with sinus rhythm from our Chronic Heart Failure Analysis and Registry in the Tohoku District 2 (CHART-2) Study (n = 10 219). The prognostic impact of HR increase was compared between the two groups, defined as left ventricular ejection fraction of < 50% (HFrEF) and > 50% (HFpEF). Cox regression analysis revealed that elevated baseline HR was associated with increased all-cause mortality in both groups [hazard ratio for the highest tertile (HH) 1.77 in HFrEF, P = 0.008; HH1.82 in HFpEF, P = 0.001]. However, as for mode of death, elevated HR was associated with cardiovascular (CV) death in HFpEF (HH 2.17, P = 0.012), but the association was modest in HFrEF (HH1.49, P = 0.14): in particular, impact on HF death was different between HFpEF (HH 3.79, P = 0.020) and HFrEF (HH 1.07, P = 0.864). In contrast, the prognostic impact of baseline HR on non-CV death was noted only in patients with HFrEF. β-Blocker therapy was associated with reduced HF mortality in HFrEF (hazard ratio 0.49, P = 0.038) but not in HFpEF (hazard ratio 0.64, P = 0.321). CONCLUSIONS: Elevated HR was associated with increased CV death in HFpEF compared with HFrEF, although its impact on all-cause mortality was comparable between the two groups.
Evidence for Brain Activation in Patients With Takotsubo Cardiomyopathy 査読有り

Hideaki Suzuki, Yasuharu Matsumoto, Tomohiro Kaneta, Koichiro Sugimura, Jun Takahashi, Yoshihiro Fukumoto, Shoki Takahashi, Hiroaki Shimokawa

CIRCULATION JOURNAL　78　(1)　256-258　2014年1月

DOI： 10.1253/circj.CJ-13-1276 　

ISSN：1346-9843

eISSN：1347-4820
Gender differences in clinical characteristics, treatment and long-term outcome in patients with stage C/D heart failure in Japan. Report from the CHART-2 study. 査読有り

Yasuhiko Sakata, Satoshi Miyata, Kotaro Nochioka, Masanobu Miura, Tsuyoshi Takada, Soichiro Tadaki, Jun Takahashi, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　78　(2)　428-35　2014年

DOI： 10.1253/circj.CJ-13-1009 　

ISSN：1346-9843

eISSN：1347-4820

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BACKGROUND: The gender differences in patients with chronic heart failure (CHF) remain to be fully elucidated in the Japanese population. METHODS AND RESULTS: We examined gender differences in clinical characteristics, treatment and long-term outcome in 4,736 consecutive CHF patients in stage C/D (mean age, 69 years) out of 10,219 patients registered in the CHF Registry, named CHART-2 Study (NCT 00418041). Compared with male patients (68%, n=3,234), female patients (32%, n=1,502) were 3.8 years older and had lower prevalence of ischemic heart disease, diabetes, smoking, myocardial infarction and cancer. At baseline, women had higher prevalence of preserved left ventricular function but had higher NYHA functional class and increased brain natriuretic peptide level. In women, aspirin, β-blockers and statins were less frequently used and diuretics were more frequently used. Crude mortality rate was similar between the genders during the median 3.1-year follow-up (52.4/1,000 and 47.3/1,000 person-years for women and men, respectively, P=0.225). On multivariate Cox regression analysis, women had a reduced risk of mortality (adjusted HR, 0.791; 95% CI: 0.640-0.979, P=0.031). CONCLUSIONS: Substantial gender differences exist in stage C/D CHF patients in real-world practice in Japan. Although female CHF patients had better survival than male patients after adjustment for baseline differences, crude mortality rate was similar between the genders, possibly reflecting relatively severer clinical manifestations in women.
Emergency care of acute myocardial infarction and the great East Japan earthquake disaster. 査読有り

Kiyotaka Hao, Jun Takahashi, Kenta Ito, Satoshi Miyata, Yasuhiko Sakata, Taro Nihei, Ryuji Tsuburaya, Takashi Shiroto, Yoshitaka Ito, Yasuharu Matsumoto, Masaharu Nakayama, Satoshi Yasuda, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　78　(3)　634-43　2014年

DOI： 10.1253/circj.CJ-13-1286 　

ISSN：1346-9843

eISSN：1347-4820

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BACKGROUND: Although emergency care of acute myocardial infarction (AMI) could theoretically be improved through improved patient delay, this notion remains to be confirmed. Additionally, the influence of large earthquakes on the emergency care of AMI cases remains to be elucidated. The Great East Japan Earthquake (March 11, 2011) has enabled us to address these issues. METHODS AND RESULTS: We analyzed the data from 2008 to 2011 (n=3,937) in the Miyagi AMI Registry Study. In-hospital mortality was significantly lower in 2011 as compared with the previous 3 years (7.3% vs. 10.5%, P<0.05). This improvement was noted especially during the first 2 months after the Earthquake, associated with shorter elapsing time from onset to admission (120 vs. 240min, P<0.001) and higher performance rate of primary percutaneous coronary intervention (PCI) (86.8% vs. 76.2%, P<0.01). Importantly, after the Earthquake, patients with early admission (≤3h from onset) was significantly increased (59.1% vs. 47.0%, P<0.05) and their prognosis became better (7.9% vs. 11.4%, P=0.02), associated with a lower prevalence of heart failure on admission (6.9% vs. 16.2%, P=0.02) and higher performance rate of primary PCI (89.1% vs. 76.4%, P<0.01). CONCLUSIONS: Emergency care of AMI improved soon after the Great East Japan Earthquake compared with ordinary times by the contribution of earlier admission from onset and higher performance rate of primary PCI. (Circ J 2014; 78: 634-643).
Circadian variation of Rho-kinase activity in circulating leukocytes of patients with vasospastic angina. 査読有り

Taro Nihei, Jun Takahashi, Ryuji Tsuburaya, Yoshitaka Ito, Takashi Shiroto, Kiyotaka Hao, Yusuke Takagi, Yasuharu Matsumoto, Masaharu Nakayama, Satoshi Miyata, Yasuhiko Sakata, Kenta Ito, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　78　(5)　1183-90　2014年

DOI： 10.1253/circj.CJ-13-1458 　

ISSN：1346-9843

eISSN：1347-4820

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BACKGROUND: Vasospastic angina (VSA) is known to exhibit circadian variation with an early morning peak. We examined whether Rho-kinase activity in circulating leukocytes, which is a useful biomarker for disease activity assessment of VSA, exhibits circadian variation in patients with VSA. METHODS AND RESULTS: In consecutive 31 VSA patients (M/F 23/8, 57±13 [SD] years) and 18 non-VSA patients (M/F 8/10, 57±14 years), we measured Rho-kinase activity in circulating leukocytes at 6:00, 12:00 and 21:00. We also examined the relationship between the Rho-kinase activity and coronary vasomotor responses during provocation test. Rho-kinase activity was significantly higher in VSA patients than in non-VSA patients at 6:00 (1.17±0.17 vs. 0.92±0.22, P<0.001), and showed a significant circadian variation with a peak at 6:00 (1.00±0.15 at 21:00, 1.17±0.17 at 6:00 and 1.12±0.22 at 12:00, P<0.001) in VSA patients, whereas no such variation was noted in non-VSA patients. Importantly, Rho-kinase activity at spasm provocation test was significantly correlated with basal coronary tone defined by vasodilating responses to intracoronary nitrate (r=0.40, P<0.05) and coronary vasoconstricting responses to acetylcholine (r=0.44, P<0.05) in VSA patients. Furthermore, their Rho-kinase activity at 6:00 was positively correlated with nocturnal parasympathetic activity as evaluated by heart rate variability in Holter monitoring (r=0.48, P<0.05). CONCLUSIONS: Rho-kinase activity exhibits distinct circadian variation associated with alterations in coronary vasomotor responses and autonomic activity in VSA patients.
Prevalence, predictors and prognosis of patients with heart failure requiring nursing care. 査読有り

Masanobu Miura, Yasuhiko Sakata, Kotaro Nochioka, Tsuyoshi Takada, Soichiro Tadaki, Ryoichi Ushigome, Takeshi Yamauchi, Jun Takahashi, Satoshi Miyata, Nobuyuki Shiba, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　78　(9)　2276-83　2014年

DOI： 10.1253/circj.CJ-14-0387 　

ISSN：1346-9843

eISSN：1347-4820

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BACKGROUND: Although the need for nursing care (NC) in heart failure (HF) patients is recognized, detailed information on the current status in Japan is lacking. METHODS AND RESULTS: In the CHART-2 Study, we obtained information on daily life, physical ability, nutrition and mental status for 4,174 patients (mean age, 67.1±10.8 years; 73.3% male) out of 10,219 patients. We examined the prevalence, baseline characteristics and clinical outcomes of stage B and C/D HF patients requiring NC. The prevalence of HF requiring NC was significantly higher in stage C/D (38.6%) than in stage B (30.4%; P<0.001). Among the reasons for requiring NC, physical dysfunction was most prevalent in both stage B (20.6%) and C/D (29.0%). Compared with the non-NC group, the NC group was characterized by higher age, higher prevalence of female gender and cerebrovascular disease, and increased plasma brain natriuretic peptide regardless of HF stage. During a median follow-up of 12.7 months after the survey, the NC group had a significantly higher mortality compared with the non-NC group (9.6% vs. 3.6%, P<0.001). On multivariate logistic analysis depressive mental status (hazard ratio [HR], 3.61; P<0.001) and dementia (HR, 2.70; P<0.001) were significantly associated with NC need. CONCLUSIONS: In HF patients, NC need is considerably high and is associated with increased mortality regardless of HF stage in Japan.
Prognostic impact of subclinical microalbuminuria in patients with chronic heart failure. 査読有り

Masanobu Miura, Yasuhiko Sakata, Satoshi Miyata, Kotaro Nochioka, Tsuyoshi Takada, Soichiro Tadaki, Ryoichi Ushigome, Takeshi Yamauchi, Jun Takahashi, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　78　(12)　2890-8　2014年

DOI： 10.1253/circj.CJ-14-0787 　

ISSN：1346-9843

eISSN：1347-4820

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BACKGROUND: Microalbuminuria, traditionally defined as urinary albumin/creatinine ratio (UACR) ≥30 mg/g, is a risk factor for mortality even in patients with preserved glomerular filtration rate (GFR). The prognostic impact of subclinical microalbuminuria, however, remains unknown in patients with chronic heart failure (CHF). METHODS AND RESULTS: In the Chronic Heart Failure Analysis and Registry in the Tohoku District 2 Study, we enrolled 2,039 consecutive symptomatic CHF patients (median age, 67.4 years; 68.9% male) after excluding those on hemodialysis. On classification and regression tree analysis, UACR=10.2 mg/g and 27.4 mg/g were identified as the first and second discriminating points to stratify the risk for composite of death, acute myocardial infarction, HF admission and stroke, therefore subclinical microalbuminuria was defined as UACR ≥10.2 and <27.4 mg/g. There were 506 composite endpoints (24.8%) during the median follow-up of 2.69 years. On Kaplan-Meier analysis and multivariate Cox modeling, subclinical microalbuminuria was significantly associated with increased composite endpoints with hazard ratios of 1.90 (P<0.001) and 2.29 (P<0.001) in patients with preserved (>60 ml·min(-1)·1.73 m(-2), n=1,129) or mildly reduced eGFR (30-59.9 ml·min(-1)·1.73 m(-2), n=789), respectively. In patients with severely reduced GFR (eGFR <30 ml·min(-1)·1.73 m(-2), n=121), >80% had microalbuminuria or macroalbuminuria, and only 9.1% were free from any composite endpoints. CONCLUSIONS: Subclinical microalbuminuria was associated with increased risk of cardiovascular events in CHF patients with mildly reduced or preserved renal function.
Rho-Kinase Activation in Patients With Heart Failure 査読有り

Zhulanqiqige, Yoshihiro Fukumoto, Koichiro Sugimura, Yutaka Miura, Shunsuke Tatebe, Saori Yamamoto, Tatsuo Aoki, Kotaro Nochioka, Suvd Nergui, Nobuhiro Yaoita, Kimio Satoh, Masateru Kondo, Makoto Nakano, Yuji Wakayama, Koji Fukuda, Taro Nihei, Yoku Kikuchi, Jun Takahashi, Hiroaki Shimokawa

CIRCULATION JOURNAL　77　(10)　2542-2550　2013年10月

DOI： 10.1253/circj.CJ-13-0397 　

ISSN：1346-9843

eISSN：1347-4820
Prognostic stratification of patients with vasospastic angina: a comprehensive clinical risk score developed by the Japanese Coronary Spasm Association. 国際誌査読有り

Yusuke Takagi, Jun Takahashi, Satoshi Yasuda, Satoshi Miyata, Ryusuke Tsunoda, Yasuhiro Ogata, Atsushi Seki, Tetsuya Sumiyoshi, Motoyuki Matsui, Toshikazu Goto, Yasuhiko Tanabe, Shozo Sueda, Toshiaki Sato, Satoshi Ogawa, Norifumi Kubo, Shin-Ichi Momomura, Hisao Ogawa, Hiroaki Shimokawa

Journal of the American College of Cardiology　62　(13)　1144-53　2013年9月24日

DOI： 10.1016/j.jacc.2013.07.018 　

ISSN：0735-1097

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OBJECTIVES: The present study aimed to develop a comprehensive clinical risk score for vasospastic angina (VSA) patients. BACKGROUND: Previous studies demonstrated various prognostic factors of future adverse events in VSA patients. However, to apply these prognostic factors in clinical practice, the assessment of their accumulation in individual patients is important. METHODS: The patient database of the multicenter registry study by the Japanese Coronary Spasm Association (JCSA) (n = 1,429; median 66 years; median follow-up 32 months) was utilized for score derivation. RESULTS: Multivariable Cox proportional hazard model selected 7 predictors of major adverse cardiac events (MACE). The integer score was assigned to each predictors proportional to their respective adjusted hazard ratio; history of out-of-hospital cardiac arrest (4 points), smoking, angina at rest alone, organic coronary stenosis, multivessel spasm (2 points each), ST-segment elevation during angina, and beta-blocker use (1 point each). According to the total score in individual patients, 3 risk strata were defined; low (score 0 to 2, n = 598), intermediate (score 3 to 5, n = 639) and high (score 6 or more, n = 192). The incidences of MACE in the low-, intermediate-, and high-risk patients were 2.5%, 7.0%, and 13.0%, respectively (p < 0.001). The Cox model for MACE between the 3 risk strata also showed prognostic utility of the scoring system in various clinical subgroups. The average prediction rate of the scoring system in the internal training and validation sets were 86.6% and 86.5%, respectively. CONCLUSIONS: We developed a novel scoring system, the JCSA risk score, which may provide the comprehensive risk assessment and prognostic stratification for VSA patients.
糖尿病患者の心疾患治療のevidence 糖代謝異常を有する虚血性心不全症例の予後予測における尿蛋白評価の意義査読有り

三浦正暢, 坂田泰彦, 後岡広太郎, 高田剛史, 但木壮一郎, 宮田敏, 高橋潤, 下川宏明

日本心臓病学会誌　8　(Suppl.I)　147-147　2013年9月
出版者・発行元： (一社)日本心臓病学会
ISSN：1882-4501
心不全における収縮不全と拡張不全のトピックス収縮能の低下した心不全と左室収縮能の保持された心不全患者における心拍数の予後に及ぼす影響の比較査読有り

高田剛史, 坂田泰彦, 宮田敏, 高橋潤, 後岡広太郎, 三浦正暢, 但木壮一郎, 下川宏明

日本心臓病学会誌　8　(Suppl.I)　171-171　2013年9月
出版者・発行元： (一社)日本心臓病学会
ISSN：1882-4501
急性心筋梗塞の救急医療と東日本大震災(Emergency Care of Acute Myocardial Infarction and the Great East Japan Earthquake Disaster) 査読有り

羽尾清貴, 高橋潤, 伊藤健太, 宮田敏, 坂田泰彦, 二瓶太郎, 圓谷隆治, 白戸崇, 伊藤愛剛, 松本泰治, 中山雅晴, 安田聡, 下川宏明

日本心臓病学会誌　8　(Suppl.I)　243-243　2013年9月
出版者・発行元： (一社)日本心臓病学会
ISSN：1882-4501
Interactions between the heart and the brain in heart failure patients assessed by magnetic resonance imaging - interim results from Brain assessment and investigation in Heart Failure Trial (B-HeFT) 査読有り

H. Suzuki, Y. Matsumoto, H. Ota, Y. Kotozaki, J. Takahashi, K. Ito, Y. Fukumoto, R. Kawashima, Y. Taki, H. Shimokawa

European Heart Journal　34　(suppl 1)　P2732-P2732　2013年8月2日
出版者・発行元： Oxford University Press (OUP)
DOI： 10.1093/eurheartj/eht309.p2732 　

ISSN：0195-668X

eISSN：1522-9645
A case report of very late stent thrombosis with peri-stent coronary artery aneurysm and stent-related coronary vasospasm 査読有り

Morihiko Takeda, Nobuyuki Shiba, Jun Takahashi, Hiroaki Shimokawa

Cardiovascular Intervention and Therapeutics　28　(3)　272-278　2013年7月

DOI： 10.1007/s12928-012-0155-7 　

ISSN：1868-4300 1868-4297
Gender Differences in the Clinical Characteristics and Outcomes of Patients With Vasospastic Angina - A Report From the Japanese Coronary Spasm Association 査読有り

Akiko Kawana, Jun Takahashi, Yusuke Takagi, Satoshi Yasuda, Yasuhiko Sakata, Ryusuke Tsunoda, Yasuhiro Ogata, Atsushi Seki, Tetsuya Sumiyoshi, Motoyuki Matsui, Toshikazu Goto, Yasuhiko Tanabe, Shozo Sueda, Norifumi Kubo, Shin-ichi Momomura, Hisao Ogawa, Hiroaki Shimokawa

CIRCULATION JOURNAL　77　(5)　1267-1274　2013年5月

DOI： 10.1253/circj.CJ-12-1486 　

ISSN：1346-9843
体外循環時ヘパリン抵抗性に対するアンチトロンビンIII製剤使用の検討

河津聡, 神田桂輔, 鈴木智之, 片平晋太郎, 高橋悟朗, 増田信也, 齋木佳克, 安達理, 秋山正年, 熊谷紀一郎, 本吉直孝, 川本俊輔

日本心臓血管外科学会雑誌　42　(Supplement)　481-481　2013年
出版者・発行元： (NPO)日本心臓血管外科学会
ISSN：0285-1474

eISSN：1883-4108
植込み型補助人工心臓保険償還1年後の実績と今後の課題

秋山正年, 片平晋太郎, 河津聡, 高橋悟朗, 秋場美紀, 草刈亜紀子, 清水裕也, 中畑仁志, 松浦健, 本吉直孝, 川本俊輔, 福田浩二, 福本義弘, 山家智之, 下川宏明, 齋木佳克

移植　48　(1)　63-63　2013年
出版者・発行元： (一社)日本移植学会
ISSN：0578-7947

eISSN：2188-0034
植込み型補助人工心臓(LVAD)を装着した重症心不全への心臓リハビリテーションの効果

鈴木文歌, 伊藤修, 森信芳, 高橋珠緒, 坂田佳子, 長坂誠, 海老原覚, 仲富千瑞, 南島大輔, 新國悦弘, 秋山正年, 川本俊輔, 齋木佳克, 上月正博

運動器リハビリテーション　24　(1)　65-71　2013年
出版者・発行元：日本運動器科学会
ISSN：2187-8420
収縮性心膜炎に対する心膜切除範囲が血行動態に与える影響

秋山正年, 河津聡, 増田信也, 高橋悟朗, 熊谷紀一郎, 安達理, 本吉直孝, 川本俊輔, 齋木佳克

日本心臓血管外科学会雑誌　42　(Supplement)　493-493　2013年
出版者・発行元： (NPO)日本心臓血管外科学会
ISSN：0285-1474

eISSN：1883-4108
選択的肋間動脈冷却血液灌流(D-HIAP)を用いた胸腹部大動脈瘤手術における対麻痺予防対策

伊藤校輝, 鈴木佑輔, 佐藤充, 河津聡, 高橋悟朗, 安達理, 秋山正年, 熊谷紀一郎, 本吉直孝, 川本俊輔, 齋木佳克

日本血管外科学会雑誌　22　(2)　216-216　2013年
出版者・発行元： (NPO)日本血管外科学会
ISSN：0918-6778

eISSN：1881-767X
活動期大動脈弁感染性心内膜炎,人工弁感染における基部置換術の検討

増田信也, 片平晋太郎, 松尾諭志, 伊藤校輝, 早津幸弘, 鈴木佑輔, 河津聡, 高橋悟朗, 齋藤武志, 安達理, 秋山正年, 熊谷紀一郎, 本吉直孝, 川本俊輔, 齋木佳克

日本心臓血管外科学会雑誌　42　(Supplement)　209-209　2013年
出版者・発行元： (NPO)日本心臓血管外科学会
DOI： 10.4326/jjcvs.42.S209 　

ISSN：0285-1474

eISSN：1883-4108
Clinical implications of provocation tests for coronary artery spasm: safety, arrhythmic complications, and prognostic impact: Multicentre Registry Study of the Japanese Coronary Spasm Association 査読有り

Yusuke Takagi, Satoshi Yasuda, Jun Takahashi, Ryusuke Tsunoda, Yasuhiro Ogata, Atsushi Seki, Tetsuya Sumiyoshi, Motoyuki Matsui, Toshikazu Goto, Yasuhiko Tanabe, Shozo Sueda, Toshiaki Sato, Satoshi Ogawa, Norifumi Kubo, Shin-ichi Momomura, Hisao Ogawa, Hiroaki Shimokawa

EUROPEAN HEART JOURNAL　34　(4)　258-267　2013年1月

DOI： 10.1093/eurheartj/ehs199 　

ISSN：0195-668X
Plasma cyclophilin a is a novel biomarker for coronary artery disease 査読有り

Kimio Satoh, Yoshihiro Fukumoto, Koichiro Sugimura, Yutaka Miura, Tatsuo Aoki, Kotaro Nochioka, Shunsuke Tatebe, Saori Miyamichi-Yamamoto, Toru Shimizu, Shizuka Osaki, Yusuke Takagi, Ryuji Tsuburaya, Yoshitaka Ito, Yasuharu Matsumoto, Masaharu Nakayama, Morihiko Takeda, Jun Takahashi, Kenta Ito, Satoshi Yasuda, Hiroaki Shimokawa

Circulation Journal　77　(2)　447-455　2013年

DOI： 10.1253/circj.CJ-12-0805 　

ISSN：1346-9843 1347-4820
Effect of the Great East Japan Earthquake on cardiovascular diseases--report from the 10 hospitals in the disaster area. 査読有り

Tatsuo Aoki, Jun Takahashi, Yoshihiro Fukumoto, Satoshi Yasuda, Kenta Ito, Satoshi Miyata, Tsuyoshi Shinozaki, Kanichi Inoue, Tetsuo Yagi, Tatsuya Komaru, Yoshiaki Katahira, Atsushi Obata, Tetsuya Hiramoto, Hiroyasu Sukegawa, Kazunori Ogata, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　77　(2)　490-3　2013年

DOI： 10.1253/circj.CJ-12-1594 　

ISSN：1346-9843

eISSN：1347-4820

詳細を見る詳細を閉じる

BACKGROUND: We reported an increased occurrence of cardiovascular diseases (CVDs) after the Great East Japan Earthquake by examining ambulance records, but it had to be confirmed by cardiologists. METHODS AND RESULTS: We enrolled patients admitted to the cardiology department of the 10 hospitals in the disaster area from 4 weeks prior to 15 weeks after March 11 in the years 2008-2011 (n=14,078). The weekly occurrence of several CVDs, including heart failure (HF), pulmonary thromboembolism (PTE) and infectious endocarditis (IE), was sharply and significantly increased after the Earthquake. CONCLUSIONS: The Disaster caused significantly increases in the occurrence of HF, PTE and IE.
Prognostic impact of blood urea nitrogen changes during hospitalization in patients with acute heart failure syndrome. 査読有り

Masanobu Miura, Yasuhiko Sakata, Kotaro Nochioka, Jun Takahashi, Tsuyoshi Takada, Satoshi Miyata, Tetsuya Hiramoto, Kan-ichi Inoue, Kenji Tamaki, Nobuyuki Shiba, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　77　(5)　1221-8　2013年

DOI： 10.1253/circj.CJ-12-1390 　

ISSN：1346-9843

eISSN：1347-4820

詳細を見る詳細を閉じる

BACKGROUND: Elevated blood urea nitrogen (BUN) observed in patients hospitalized for acute heart failure syndrome (AHFS) may represent increased neurohumoral activation. The purpose of this study was to examine the prognostic impact of BUN changes during hospitalization on the long-term prognosis of AHFS patients. METHODS AND RESULTS: The Tohoku Acute Heart Failure Registry (n=497) is a multicenter retrospective cohort study enrolling AHFS patients who were admitted in 2007. The 337 survivors (mean age, 76 years; 52% male) were divided into 3 groups according to tertiles of BUN change during hospitalization: Decreased (D-BUN, ΔBUN (BUN level at discharge-BUN level at hospitalization)≤-1.63 mg/dl, n=112); Unchanged (U-BUN, ΔBUN-1.64 to 5.73 mg/dl, n=113); Increased (I-BUN, ΔBUN>5.73 mg/dl, n=112). The D-BUN group had higher prevalence of lowest glomerular filtration rate during hospitalization, whereas the I-BUN group had higher systolic blood pressure. During a median follow-up period of 2.3 years after discharge, the Kaplan-Meier curve showed that D-BUN and I-BUN had worse prognosis compared with U-BUN. Multivariable logistic model showed that all-cause death was more frequent in I-BUN (hazard ratio, 2.94; 95% confidence interval, 1.51-5.73; P<0.001). Subgroup analysis revealed that BUN increase during hospitalization was associated with all-cause death, regardless of renal function. CONCLUSIONS: AHFS patients with a BUN increase during hospitalization have worse long-term prognosis, independent of renal function.
Prognostic impact of nutritional status in asymptomatic patients with cardiac diseases: a report from the CHART-2 Study. 査読有り

Kotaro Nochioka, Yasuhiko Sakata, Jun Takahashi, Satoshi Miyata, Masanobu Miura, Tsuyoshi Takada, Yoshihiro Fukumoto, Nobuyuki Shiba, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　77　(9)　2318-26　2013年

DOI： 10.1253/circj.CJ-13-0127 　

ISSN：1346-9843

eISSN：1347-4820

詳細を見る詳細を閉じる

BACKGROUND: The prognostic impact of nutritional status is poorly understood in asymptomatic patients with structural and/or functional heart diseases, classified as stage B in the ESC/AHA/ACC chronic heart failure (HF) guidelines. METHODS AND RESULTS: We evaluated the impact of nutrition, using the controlling nutritional status (CONUT) score, calculated by the serum albumin and total cholesterol levels,and lymphocyte number, in 3,421 stage B patients from the Chronic Heart Failure Analysis and Registry in the Tohoku District-2 Study (mean age: 66.9±12.7 years, male: 71.6%). During a median follow-up of 2.89 years, 224 patients died from cardiovascular (45%, n=102) and noncardiovascular (55%, n=123) causes and 139 experienced hospitalization for HF. Survival at 3 years in patients with CONUT 0-1 (reference, n=2,121), 2 (n=693) and ≥3 (n=607) was 95.5, 92.3, and 73.2%, respectively (P<0.001). The adjusted Cox hazard analyses revealed that the CONUT score was significantly associated with increased incidence of all-cause death (hazard ratio 1.27 per point increase; 95% confidence interval, 1.16-1.39, P<0.001). Subgroup analysis showed that per point increase in the CONUT score was significantly associated with a 17% increase in HF hospitalization in patients ≥70 years old (P=0.049), but not in those aged <70 years. CONCLUSIONS: In the current stage B patients, poor nutritional status was associated with increased incidence of death for the overall population and of HF hospitalization for the elderly proportion.
Usefulness of combined risk stratification with heart rate and systolic blood pressure in the management of chronic heart failure. A report from the CHART-2 study. 査読有り

Masanobu Miura, Yasuhiko Sakata, Satoshi Miyata, Kotaro Nochioka, Tsuyoshi Takada, Soichiro Tadaki, Jun Takahashi, Nobuyuki Shiba, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　77　(12)　2954-62　2013年

DOI： 10.1253/circj.CJ-13-0725 　

ISSN：1346-9843

eISSN：1347-4820

詳細を見る詳細を閉じる

BACKGROUND: The appropriate target ranges of heart rate (HR) and systolic blood pressure (SBP) for the management of chronic heart failure (CHF) patients remain to be elucidated in a large-scale cohort study. METHODS AND RESULTS: We examined 3,029 consecutive CHF patients with sinus rhythm (SR) (mean age, 67.9 years) registered in the Chronic Heart Failure Analysis and Registry in the Tohoku District-2 Study (CHART-2; NCT00418041). There were 357 deaths (11.8%) during the median follow-up of 3.1 years. We first performed the classification and regression tree analysis for mortality, identifying SBP <89 mmHg, HR >70 beats/min and SBP <115 mmHg as the primary, secondary and tertiary discriminators, respectively. According to these, we divided the patients into low- (n=1,131), middle- (n=1,624) and high-risk (n=274) groups with mortality risk <10%, 10-20% and >20%, respectively. The low-risk group was characterized by SBP >115 mmHg and HR <70 beats/min and the high-risk group by SBP <89 mmHg regardless of HR values or SBP 89-115 mmHg and HR >76 beats/min. Multivariate Cox regression analysis revealed that the hazard ratio of all-cause death for low-, middle- and high-risk groups was 1.00 (reference), 1.48 (95% confidence interval (CI): 1.10-1.99, P=0.009) and 2.44 (95% CI 1.66-3.58, P<0.001), respectively. Subgroup analysis revealed that age ≥70 years, diabetes, or reduced left ventricular function had higher hazard ratios in the high-risk group. CONCLUSIONS: The results demonstrate the usefulness of combined risk stratification of HR and SBP in CHF patients with SR.
Enhanced Rho-Kinase Activity in Patients With Vasospastic Angina After the Great East Japan Earthquake 査読有り

Taro Nihei, Jun Takahashi, Yoku Kikuchi, Yusuke Takagi, Kiyotaka Hao, Ryuji Tsuburaya, Takashi Shiroto, Yoshitaka Ito, Yasuharu Matsumoto, Masaharu Nakayama, Kenta Ito, Satoshi Yasuda, Hiroaki Shimokawa

CIRCULATION JOURNAL　76　(12)　2892-2894　2012年12月

DOI： 10.1253/circj.CJ-12-1238 　

ISSN：1346-9843
Involvement of Rho-Kinase Activation in the Pathogenesis of Coronary Hyperconstricting Responses Induced by Drug-Eluting Stents in Patients With Coronary Artery Disease 査読有り

Kentaro Aizawa, Satoshi Yasuda, Jun Takahashi, Toru Takii, Yoku Kikuchi, Ryuji Tsuburaya, Yoshitaka Ito, Kenta Ito, Masaharu Nakayama, Morihiko Takeda, Hiroaki Shimokawa

CIRCULATION JOURNAL　76　(11)　2552-2560　2012年11月

DOI： 10.1253/circj.CJ-12-0662 　

ISSN：1346-9843

eISSN：1347-4820
The Great East Japan Earthquake Disaster and cardiovascular diseases. 国際誌査読有り

Tatsuo Aoki, Yoshihiro Fukumoto, Satoshi Yasuda, Yasuhiko Sakata, Kenta Ito, Jun Takahashi, Satoshi Miyata, Ichiro Tsuji, Hiroaki Shimokawa

European heart journal　33　(22)　2796-803　2012年11月

DOI： 10.1093/eurheartj/ehs288 　

ISSN：0195-668X

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AIMS: While previous studies reported a short-term increase in individual cardiovascular disease (CVD) after great earthquakes, mid-term occurrences of all types of CVDs after great earthquakes are unknown. We addressed this important issue in our experience with the Great East Japan Earthquake (11 March 2011). METHODS AND RESULTS: We retrospectively examined the impact of the Earthquake on the occurrences of CVDs and pneumonia by comparing the ambulance records made by doctors in our Miyagi Prefecture, the centre of the disaster area, during the periods of 2008-11 (n = 124,152). The weekly occurrences of CVDs, including heart failure (HF), acute coronary syndrome (ACS), stroke, cardiopulmonary arrest (CPA), and pneumonia were all significantly increased after the Earthquake compared with the previous 3 years. The occurrences of ACS and CPA showed the rapid increase followed by a sharp decline, whereas those of HF and pneumonia showed a prolonged increase for more than 6 weeks and those of stroke and CPA showed a second peak after the largest aftershock (7 April 2011). Furthermore, the occurrence of CPA was increased in the first 24 h after the Earthquake, followed by other diseases later on. These increases were independent of age, sex, or residence area (seacoast vs. inland). CONCLUSION: These results indicate that the occurrences of all types of CVDs and pneumonia were increased in somewhat different time courses after the Earthquake, including the first observation of the marked and prolonged increase in HF, emphasizing the importance of intensive medical management of all types of CVDs after great earthquakes.
東日本大震災と心臓血管疾患(The Great East Japan Earthquake Disaster and Cardiovascular Diseases)

青木竜男, 福本義弘, 安田聡, 伊藤健太, 高橋潤, 辻一郎, 下川宏明

日本心臓病学会誌　7　(Suppl.I)　245-245　2012年8月
出版者・発行元： (一社)日本心臓病学会
ISSN：1882-4501
血漿サイクロフィリンAの冠動脈疾患診断における有用性

佐藤公雄, 福本義弘, 杉村宏一郎, 三浦裕, 後岡広太郎, 青木竜男, 建部俊介, 山本沙織, 高木祐介, 圓谷隆治, 伊藤愛剛, 松本泰治, 中山雅晴, 高橋潤, 伊藤健太, 下川宏明

日本心臓病学会誌　7　(Suppl.I)　358-358　2012年8月
出版者・発行元： (一社)日本心臓病学会
ISSN：1882-4501
日本発臨床研究の紹介と反省点を語る CHART-2研究日本人の心血管病診療エビデンス構築のための10,219例の前向き登録観察研究査読有り

後岡広太郎, 三浦正暢, 柴信行, 高田剛史, 宮田敏, 高橋潤, 福本義弘, 坂田泰彦, 下川宏明

日本内科学会雑誌　101　(6)　1715-1719　2012年6月
出版者・発行元： (一社)日本内科学会
ISSN：0021-5384

eISSN：1883-2083
Urbanization, Life Style Changes and the Incidence/In-Hospital Mortality of Acute Myocardial Infarction in Japan - Report From the MIYAGI-AMI Registry Study 査読有り

Kiyotaka Hao, Satoshi Yasuda, Tori Takii, Yoshitaka Ito, Jun Takahashi, Kenta Ito, Masaharu Nakayama, Nobuyuki Shiba, Yoshihiro Fukumoto, Hiroaki Shimokawa

CIRCULATION JOURNAL　76　(5)　1136-1144　2012年5月

DOI： 10.1253/circj.CJ-11-1233 　

ISSN：1346-9843

eISSN：1347-4820
Urinary albumin excretion in heart failure with preserved ejection fraction: an interim analysis of the CHART 2 study 査読有り

Masanobu Miura, Nobuyuki Shiba, Kotaro Nochioka, Tsuyoshi Takada, Jun Takahashi, Haruka Kohno, Hiroaki Shimokawa

EUROPEAN JOURNAL OF HEART FAILURE　14　(4)　367-376　2012年4月

DOI： 10.1093/eurjhf/hfs001 　

ISSN：1388-9842
Long-term treatment with nifedipine suppresses coronary hyperconstricting responses and inflammatory changes induced by paclitaxel-eluting stent in pigs in vivo: possible involvement of Rho-kinase pathway 査読有り

Ryuji Tsuburaya, Satoshi Yasuda, Takashi Shiroto, Yoshitaka Ito, Jun Yi Gao, Kentaro Aizawa, Yoku Kikuchi, Kenta Ito, Jun Takahashi, Hatsue Ishibashi-Ueda, Hiroaki Shimokawa

EUROPEAN HEART JOURNAL　33　(6)　791-799　2012年3月

DOI： 10.1093/eurheartj/ehr145 　

ISSN：0195-668X
当科における人工心臓挿入部のスキンケア

片平晋太郎, 秋山正年, 本吉直孝, 高橋悟朗, 神田桂輔, 川本俊輔, 齋木佳克

人工臓器(日本人工臓器学会)　41　(2)　S-47　2012年
出版者・発行元： (一社)日本人工臓器学会
ISSN：0300-0818

eISSN：1883-6097
術前ヘパリン起因性血小板減少症を併発した拡張型心筋症患者に対して植込み型左心補助人工心臓を装着した1例

秋山正年, 神田桂輔, 片平晋太郎, 高橋悟朗, 本吉直孝, 川本俊輔, 齋木佳克

人工臓器(日本人工臓器学会)　41　(2)　S-147　2012年
出版者・発行元： (一社)日本人工臓器学会
ISSN：0300-0818

eISSN：1883-6097
植え込み型補助人工心臓承認後の重症心不全治療戦略についての検討

秋山正年, 片平晋太郎, 河津聡, 高橋悟朗, 秋場美紀, 本吉直孝, 川本俊輔, 齋木佳克

人工臓器(日本人工臓器学会)　41　(2)　S-33　2012年
出版者・発行元： (一社)日本人工臓器学会
ISSN：0300-0818

eISSN：1883-6097
Enhanced Rho-Kinase Activity in Circulating Neutrophils of Patients With Vasospastic Angina A Possible Biomarker for Diagnosis and Disease Activity Assessment 査読有り

Yoku Kikuchi, Satoshi Yasuda, Kentaro Aizawa, Ryuji Tsuburaya, Yoshitaka Ito, Morihiko Takeda, Masaharu Nakayama, Kenta Ito, Jun Takahashi, Hiroaki Shimokawa

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY　58　(12)　1231-1237　2011年9月

DOI： 10.1016/j.jacc.2011.05.046 　

ISSN：0735-1097

eISSN：1558-3597
Optical Coherence Tomographyを用いた攣縮を生じる冠動脈の微細構造の解析局所性冠攣縮とびまん性冠攣縮の差異

武田守彦, 高橋潤, 伊藤健太, 中山雅晴, 安田聡, 下川宏明

日本心臓病学会誌　6　(Suppl.I)　470-470　2011年8月
出版者・発行元： (一社)日本心臓病学会
ISSN：1882-4501
急性心筋梗塞後心破裂を合併し救命後、慢性期左室仮性瘤形成のため再手術を要した症例査読有り

大橋潤子, 松本泰治, 高橋潤, 武田守彦, 伊藤健太, 中山雅晴, 伊藤愛剛, 圓谷隆治, 高木祐介, 安田聡, 北向修, 川本俊輔, 齋木佳克, 下川宏明

日本心臓病学会誌　6　(Suppl.I)　455-455　2011年8月
出版者・発行元： (一社)日本心臓病学会
ISSN：1882-4501
院外心停止の成因における冠攣縮と心室細動の重要性

高本祐介, 安田聡, 高橋潤, 武田守彦, 中山雅晴, 伊藤健太, 広瀬尚徳, 若山裕司, 福田浩二, 下川宏明

心臓　42　(Suppl.2)　172-172　2010年8月
出版者・発行元： (公財)日本心臓財団
ISSN：0586-4488

eISSN：2186-3016
器質的心疾患のない院外心停止の病態と予後冠攣縮と心室細動の二重誘発試験の重要性

高木祐介, 安田聡, 高橋潤, 武田守彦, 中山雅晴, 伊藤健太, 若山裕司, 福田浩二, 下川宏明

日本心臓病学会誌　5　(Suppl.I)　219-219　2010年8月
出版者・発行元： (一社)日本心臓病学会
ISSN：1882-4501
腹部大動脈瘤患者における術前冠動脈造影及び冠血行再建術の有用性

武田守彦, 高橋潤, 伊藤健太, 中山雅晴, 安田聡, 下川宏明

日本心臓病学会誌　5　(Suppl.I)　325-325　2010年8月
出版者・発行元： (一社)日本心臓病学会
ISSN：1882-4501
Trends in Acute Myocardial Infarction Incidence and Mortality Over 30 Years in Japan: 査読有り

Takii T, Yasuda S, Takahashi J, Ito K, Shiba N, Shirato K, Shimokawa H

Circ J　74　(1)　93-100　2010年4月

DOI： 10.1253/circj.CJ-09-0619 　
冠攣縮誘発試験時にBrugada様心電図変化を呈した冠攣縮性狭心症の1例査読有り

眞野唯, 武田守彦, 近藤正輝, 中山雅晴, 伊藤健太, 高橋潤, 福田浩二, 安田聡, 加賀谷豊, 下川宏明

心臓　42　(3)　360-364　2010年3月
出版者・発行元： (公財)日本心臓財団
DOI： 10.11281/shinzo.42.360 　

ISSN：0586-4488

eISSN：2186-3016
Double-Blind and Placebo-Controlled Study of the Effectiveness and Safety of Extracorporeal Cardiac Shock Wave Therapy for Severe Angina Pectoris 査読有り

Yoku Kikuchi, Kenta Ito, Yoshitaka Ito, Takashi Shiroto, Ryuji Tsuburaya, Kentaro Aizawa, Kiyotaka Hao, Yoshihiro Fukumoto, Jun Takahashi, Morihiko Takeda, Masaharu Nakayama, Satoshi Yasuda, Shinichi Kuriyama, Ichiro Tsuji, Hiroaki Shimokawa

CIRCULATION JOURNAL　74　(3)　589-591　2010年3月

DOI： 10.1253/circj.CJ-09-1028 　

ISSN：1346-9843
Double-Blind and Placebo-Controlled Study of the Effectiveness and Safety of Extracorporeal Cardiac Shock Wave Therapy for Severe Angina Pectoris 査読有り

Yoku Kikuchi, Kenta Ito, Yoshitaka Ito, Takashi Shiroto, Ryuji Tsuburaya, Kentaro Aizawa, Kiyotaka Hao, Yoshihiro Fukumoto, Jun Takahashi, Morihiko Takeda, Masaharu Nakayama, Satoshi Yasuda, Shinichi Kuriyama, Ichiro Tsuji, Hiroaki Shimokawa

CIRCULATION JOURNAL　74　(3)　589-591　2010年3月

DOI： 10.1253/circj.CJ-09-1028 　

ISSN：1346-9843
心臓血管外科領域における凍結保存ホモグラフト移植手術の検討

川本俊輔, 齋木佳克, 小田克彦, 赤坂純逸, 本吉直孝, 熊谷紀一郎, 秋山正年, 齋藤武志, 高橋悟朗, 渋谷拓見, 佐藤真一, 井口篤志, 田林晄一, 本村昇

日本心臓血管外科学会雑誌　39　(Suppl.)　320-320　2010年1月
出版者・発行元： (NPO)日本心臓血管外科学会
ISSN：0285-1474

eISSN：1883-4108
Trends in Acute Myocardial Infarction Incidence and Mortality Over 30 Years in Japan: Report From the MIYAGI-AMI Registry Study 査読有り

Toru Takii, Satoshi Yasuda, Jun Takahashi, Kenta Ito, Nobuyuki Shiba, Kunio Shirato, Hiroaki Shimokawa

CIRCULATION JOURNAL　74　(1)　93-100　2010年1月

DOI： 10.1253/circj.CJ-09-0619 　

ISSN：1346-9843

eISSN：1347-4820
Role of Rho-Kinase in the Pathogenesis of Coronary Hyperconstricting Responses Induced by Drug-Eluting Stents in Pigs In Vivo 査読有り

Takashi Shiroto, Satoshi Yasuda, Ryuji Tsuburaya, Yoshitaka Ito, Jun Takahashi, Kenta Ito, Hatsue Ishibashi-Ueda, Hiroaki Shimokawa

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY　54　(24)　2321-2329　2009年12月

DOI： 10.1016/j.jacc.2009.07.045 　

ISSN：0735-1097

eISSN：1558-3597
Role of Rho-Kinase in the Pathogenesis of Coronary Hyperconstricting Responses Induced by Drug-Eluting Stents in Pigs In Vivo 査読有り

Takashi Shiroto, Satoshi Yasuda, Ryuji Tsuburaya, Yoshitaka Ito, Jun Takahashi, Kenta Ito, Hatsue Ishibashi-Ueda, Hiroaki Shimokawa

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY　54　(24)　2321-2329　2009年12月

DOI： 10.1016/j.jacc.2009.07.045 　

ISSN：0735-1097

eISSN：1558-3597
宮城県における急性心筋梗塞発症30年間の変遷 MIYAGI-AMI研究から

瀧井暢, 高橋潤, 安田聡, 高木祐介, 伊藤愛剛, 中山雅晴, 武田守彦, 伊藤健太, 下川宏明

日本心臓病学会誌　4　(Suppl.I)　205-205　2009年8月
出版者・発行元： (一社)日本心臓病学会
ISSN：1882-4501
多枝攣縮に伴う多様な心電図変化と特異なMRI所見を伴った急性心筋梗塞症例

佐藤直実, 高橋潤, 瀧井暢, 武田守彦, 中山雅晴, 伊藤健太, 高木祐介, 安田聡, 下川宏明

日本心臓病学会誌　4　(Suppl.I)　381-381　2009年8月
出版者・発行元： (一社)日本心臓病学会
ISSN：1882-4501
Importance of Dual Induction Tests for Coronary Vasospasm and Ventricular Fibrillation in Patients Surviving Out-of-Hospital Cardiac Arrest 査読有り

Yusuke Takagi, Satoshi Yasuda, Jun Takahashi, Morihiko Takeda, Masaharu Nakayama, Kenta Ito, Masanori Hirose, Yuji Wakayama, Koji Fukuda, Hiroaki Shimokawa

CIRCULATION JOURNAL　73　(4)　767-769　2009年4月

DOI： 10.1253/circj.CJ-09-0061 　

ISSN：1346-9843
埋め込み型LVASによる在宅管理

秋山正年, 齋木佳克, 赤坂純逸, 高橋吾朗, 秋場美紀, 清水裕也, 中畑仁志, 井口篤志, 田林晄一

人工臓器(日本人工臓器学会)　38　(2)　S-24　2009年
出版者・発行元： (一社)日本人工臓器学会
ISSN：0300-0818

eISSN：1883-6097
LVAD装着後右心不全発症についての検討

秋山正年, 井口篤志, 齋木佳克, 小田克彦, 赤坂純逸, 川本俊輔, 本吉直孝, 熊谷紀一郎, 高橋悟朗, 渋谷拓見, 佐藤真一, 佐藤敦彦, 加賀谷智明, 田林晄一

人工臓器(日本人工臓器学会)　38　(2)　S-87　2009年
出版者・発行元： (一社)日本人工臓器学会
ISSN：0300-0818

eISSN：1883-6097
ドレナージカテーテル搭載型脊髄虚血モニタリング用超音波センサ

柳田秀彰, 松永忠雄, 齋木佳克, 長井裕, 本吉直孝, 高橋悟朗, 佐藤敦彦, 江刺正喜, 芳賀洋一

生体医工学　47　(4)　374-374　2009年
出版者・発行元： (公社)日本生体医工学会
ISSN：1347-443X

eISSN：1881-4379
胸部大動脈瘤手術における,術前腎機能と術後腎不全率,病院死亡率の関係

赤坂純逸, 齋木佳克, 小田克彦, 川本俊輔, 本吉直孝, 秋山正年, 高橋悟朗, 渋谷拓見, 佐藤真一, 加賀谷智明, 佐藤敦彦, 佐藤充, 井口篤志, 田林晄一

日本心臓血管外科学会雑誌　38　(Supplement)　283-283　2009年
出版者・発行元： (NPO)日本心臓血管外科学会
ISSN：0285-1474

eISSN：1883-4108
胸部大動脈疾患に対するステント内挿術の治療成績の検討

川本俊輔, 赤坂純逸, 齋木佳克, 小田克彦, 本吉直孝, 秋山正年, 高橋悟朗, 渋谷拓見, 佐藤真一, 井口篤志, 田林晄一

日本心臓血管外科学会雑誌　38　(Supplement)　201-201　2009年
出版者・発行元： (NPO)日本心臓血管外科学会
ISSN：0285-1474

eISSN：1883-4108
Emerging Problems of Heart Failure Practice in Japanese Women - Lessons From the CHART Study 査読有り

Nobuyuki Shiba, Kotaro Nochioka, Haruka Kohno, Mika Matsuki, Jun Takahashi, Tomohiro Tada, Yutaka Kagaya, Hiroaki Shiniokawa

CIRCULATION JOURNAL　72　(12)　2009-2014　2008年12月

DOI： 10.1253/circj.CJ-07-1000 　

ISSN：1346-9843
重症貧血に伴い不安定狭心症を呈した1例

川口典彦, 越田亮司, 高橋潤, 中山雅晴, 武田守彦, 伊藤健太, 安田聡, 加賀谷豊, 下川宏明

Circulation Journal　72　(Suppl.III)　1053-1053　2008年10月
出版者・発行元： (一社)日本循環器学会
ISSN：1346-9843

eISSN：1347-4820
冠動脈バイパス術後のelectrical stormにPCPSが有効であった1例

瀧井暢, 伊藤健太, 高橋潤, 越田亮司, 中山雅晴, 武田守彦, 多田智洋, 安田聡, 下川宏明, 小田克彦, 鎌田誠, 本吉直孝, 渋谷拓見, 田林晄一

Circulation Journal　72　(Suppl.III)　1053-1053　2008年10月
出版者・発行元： (一社)日本循環器学会
ISSN：1346-9843

eISSN：1347-4820
院外心停止に冠攣縮の関与が疑われた1例心臓査読有り

安田聡, 高橋潤, 下川宏明

Ｓｕｐｐｌ　40　132-137　2008年4月

DOI： 10.11281/shinzo1969.40.Supplement3_132 　
Prognostic importance of chronic kidney disease in Japanese patients with chronic heart failure - Implications of the CHART study 査読有り

Nobuyuki Shiba, Mika Matsuki, Jun Takahashi, Tomohiro Tada, Jun Watanabe, Hiroaki Shimokawa

CIRCULATION JOURNAL　72　(2)　173-178　2008年2月

DOI： 10.1253/circj.72.173 　

ISSN：1346-9843
Depressed contractile reserve and impaired calcium handling of cardiac myocytes from chronically unloaded hearts are ameliorated with the administration of physiological treatment dose of T3 in rats 査読有り

Y. Minatoya, K. Ito, Y. Kagaya, Y. Asaumi, M. Takeda, M. Nakayama, J. Takahashi, A. Iguchi, K. Shirato, H. Shimokawa

ACTA PHYSIOLOGICA　189　(3)　221-231　2007年3月

DOI： 10.1111/j.1748-1716.2006.01636.x 　

ISSN：1748-1708
微量の甲状腺ホルモン療法は、慢性減負荷環境における心機能およびカルシウム調節機能の低下を抑制する

湊谷豊, 伊藤健太, 加賀谷豊, 浅海泰栄, 中山雅晴, 高橋潤, 矢作浩一, 武田守彦, 井口篤志, 白土邦男, 下川宏明

Circulation Journal　70　(Suppl.III)　1135-1135　2006年10月
出版者・発行元： (一社)日本循環器学会
ISSN：1346-9843

eISSN：1347-4820
長時間CPR後、開胸下PCPS装着にて救命できた劇症型心筋炎の1症例

矢作浩一, 岩渕薫, 高橋克明, 福田浩二, 深堀耕平, 高橋潤, 下川宏明, 白土邦男, 齋木佳克, 赤坂純逸, 井口篤志, 田林晄一

Circulation Journal　70　(Suppl.III)　1134-1134　2006年10月
出版者・発行元： (一社)日本循環器学会
ISSN：1346-9843

eISSN：1347-4820
Reduced inotropic effect of Nifekalant in failing hearts in rats 査読有り

Hideaki Endo, Masahito Miura, Masanori Hirose, Jun Takahashi, Makoto Nakano, Yuji Wakayama, Yoshinao Sugai, Yutaka Kagaya, Jun Watanabe, Kunio Shirato, Hiroaki Shimokawa

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS　318　(3)　1102-1107　2006年9月

DOI： 10.1124/jpet.106.102780 　

ISSN：0022-3565
Differential regulation of diacylglycerol kinase isozymes in cardiac hypertrophy 査読有り

H Yahagi, M Takeda, Y Asaumi, K Okumura, R Takahashi, J Takahashi, J Ohta, H Tada, Y Minatoya, M Sakuma, J Watanabe, K Goto, K Shirato, Y Kagaya

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　332　(1)　101-108　2005年6月

DOI： 10.1016/j.bbrc.2005.04.094 　

ISSN：0006-291X
Deficit of CD38/cyclic ADP-ribose is differentially compensated in hearts by gender 査読有り

J Takahashi, Y Kagaya, Kato, I, J Ohta, S Isoyama, M Miura, Y Sugai, M Hirose, Y Wakayama, M Ninomiya, J Watanabe, S Takasawa, H Okamoto, K Shirato

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　312　(2)　434-440　2003年12月

DOI： 10.1016/j.bbrc.2003.10.143 　

ISSN：0006-291X

eISSN：1090-2104
致命的な壊死性筋膜炎を合併した甲状腺クリーゼによる心不全の1例

高橋潤, 岩渕薫, 武田守彦, 大谷宏紀, 出町順, 若山裕司, 杉江正, 白土邦男

Circulation Journal　67　(Suppl.III)　902-902　2003年10月
出版者・発行元： (一社)日本循環器学会
ISSN：1346-9843

eISSN：1347-4820
Should increasing the dose or adding an AT(1) receptor blocker follow a relatively low dose of ACE inhibitor initiated in acute myocardial infarction? 査読有り

T Sugie, Y Kagaya, M Takeda, H Yahagi, C Takahashi, J Takahashi, M Ninomiya, J Watanabe, R Ichinohasama, F Tezuka, K Shirato

CARDIOVASCULAR RESEARCH　58　(3)　611-620　2003年6月

DOI： 10.1016/S0008-6363(03)00318-3 　

ISSN：0008-6363
アンジオテンシン変換酵素阻害薬単独とアンジオテンシン受容体拮抗薬併用のいずれがラット梗塞後心室リモデリング抑制に優れているか?

杉江正, 加賀谷豊, 高橋務子, 武田守彦, 菅井義尚, 高橋潤, 白土邦男, 一迫玲, 手塚文明

Japanese Circulation Journal　65　(Suppl.III)　705-705　2001年10月
出版者・発行元： (一社)日本循環器学会
ISSN：0047-1828

eISSN：1347-4839
Gene expression and in situ localization of diacylglycerol kinase isozymes in normal and infarcted rat hearts - Effects of captopril treatment 査読有り

M Takeda, Y Kagaya, J Takahashi, T Sugie, J Ohta, J Watanabe, K Shirato, H Kondo, K Goto

CIRCULATION RESEARCH　89　(3)　265-272　2001年8月

ISSN：0009-7330

︎全件表示 ︎最初の5件までを表示

MISC 289

重症STEMI患者に対する適切な補助循環の使用選択により植え込み型LVADへのbridgeに成功した一例

吉町文子, 進藤智彦, 神戸茂雄, 西宮健介, 羽尾清貴, 白戸崇, 高橋潤, 安田聡, 細山勝寛, 鈴木祐輔, 片平晋太郎, 齋木佳克

東北医学雑誌　136　(2)　77-80　2024年12月
出版者・発行元：東北医学会
ISSN： 0040-8700
HFpEF患者における致死性不整脈リスク因子の同定

伊藤知宏, 野田崇, 後岡広太郎, 佐藤宏行, 白戸崇, 中野誠, 高濱博幸, 高橋潤, 下川宏明, 安田聡

日本心臓病学会学術集会(Web)　72nd　2024年
高齢者における循環器疾患に対する応用薬理慢性心不全患者における脳由来成長因子(BDNF)と脳灰白質量との関連慢性心不全における脳の構造・機能に関する縦断研究(B-HeFT2)

鈴木秀明, 松本泰治, 大田英揮, 杉村宏一郎, 後岡広太郎, 高橋潤, 宮田敏, 古川勝敏, 福本義弘, 瀧靖之, 下川宏明, 安田聡

応用薬理　102　(5-6)　123-123　2022年8月
出版者・発行元：応用薬理研究会
ISSN： 0300-8533
Comparison of Long-term Mortality of Transcatheter Aortic Valve Implantation between Patients Aged ≧80 Years and those <80 Years(和訳中)

菊地翼, 高橋潤, 羽尾清貴, 西宮健介, 神戸茂雄, 勝田祐子, 須田彬, 進藤智彦, 白戸崇, 熊谷紀一郎, 齋木佳克, 安田聡

日本循環器学会学術集会抄録集　86回　PL10-2　2022年3月
出版者・発行元： (一社)日本循環器学会
AIによる心不全のフェノマッピング:CHART-2研究より

後岡広太郎, 安田聡, 植田琢也, 白戸崇, 高橋潤, 宮田敏, 宮田敏, 下川宏明, 下川宏明

日本心不全学会学術集会プログラム・抄録集　26th　2022年
急性心筋梗塞後の心不全再入院の頻度,危険因子および予後:日本AMIレジストリ(JAMIR)からの洞察【JST・京大機械翻訳】|||

竹内智, 本田怜史, 西平賢作, 小島淳, 竹上未紗, 浅海泰栄, 佐地真育, 山下淳, 小菅雅美, 高橋潤, 坂田泰彦, 高山守正, 住吉徹哉, 小川久雄, 安田聡

日本循環器学会学術集会(Web)　86th　2022年
冠微小血管機能障害の臨床的重要性

神戸茂雄, 須田彬, 大浦翔子, 進藤智彦, 西宮健介, 菊地翼, 白戸崇, 高橋潤, 下川宏明, 下川宏明, 安田聡

日本酸化ストレス学会学術集会プログラム・抄録集　74th (CD-ROM)　2021年
TAVIは重症大動脈弁狭窄症患者のBNP値の低下に伴う冠微小血管の拡張機能障害を改善する(TAVI Improves Impaired Vasodilator Capacity of Coronary Microvessels Associated with Decreased BNP Levels in Patients with Severe Aortic Stenosis)

土屋聡, 松本泰治, 杉澤潤, 佐藤公一, 須田彬, 進藤智彦, 神戸茂雄, 西宮健介, 竹内雅史, 菊地翼, 羽尾清貴, 高橋潤, 熊谷紀一郎, 齋木佳克, 下川宏明

日本循環器学会学術集会抄録集　84回　PJ18-8　2020年7月
出版者・発行元： (一社)日本循環器学会
重症大動脈弁狭窄症に対する経カテーテル弁置換術はBNPと左室肥大の軽減に相関して冠血流予備能を改善する

土屋聡, 松本泰治, 大田英揮, 菊池翼, 杉澤潤, 佐藤公一, 須田彬, 進藤智彦, 神戸茂雄, 西宮健介, 鈴木祐輔, 高橋潤, 熊谷紀一郎, 斎木佳克, 高瀬圭, 下川宏明

日本心血管画像動態学会プログラム・抄録集　30th　2020年
自己拡張型弁を留置された冠動脈疾患に対する経皮的冠動脈インターベンション

菊地翼, 松本泰治, 土屋聡, 進藤智彦, 神戸茂雄, 西宮健介, 白戸崇, 高橋潤, 下川宏明

脈管学(Web)　60　(supplement)　2020年

ISSN： 1880-8840
非閉塞性冠動脈疾患患者における冠動脈機能異常の包括的評価

須田彬, 高橋潤, 菊地翼, 西宮健介, 進藤智彦, 神戸茂雄, 白戸崇, 渡辺翼, 福井健人, 坂田泰彦, 安田聡, 下川宏明

脈管学(Web)　60　(supplement)　2020年

ISSN： 1880-8840
冠動脈閉塞を伴わない心筋梗塞(MINOCA)患者に関する検討-宮城県AMI登録研究-

羽尾清貴, 高橋潤, 佐藤公一, 須田彬, 進藤智彦, 神戸茂雄, 西宮健介, 菊地翼, 白戸崇, 坂田泰彦, 下川宏明

脈管学(Web)　60　(supplement)　2020年

ISSN： 1880-8840
非閉塞性冠動脈疾患患者における冠動脈機能異常の性差についての検討

須田彬, 高橋潤, 菊地翼, 進藤智彦, 神戸茂雄, 西宮健介, 渡辺翼, 白戸崇, 坂田泰彦, 下川宏明, 下川宏明

脈管学(Web)　60　(supplement)　2020年

ISSN： 1880-8840
音波を用いた低侵襲治療の開発

進藤智彦, 高橋潤, 白戸崇, 菊地翼, 西宮健介, 神戸茂雄, 一條貞満, 中田貴史, 坂田泰彦, 金井浩, 安田聡, 下川宏明

脈管学(Web)　60　(supplement)　2020年

ISSN： 1880-8840
補助循環用ポンプカテーテルIMPELLAの使用経験と展望

神戸茂雄, 菊地翼, 高橋潤, 進藤智彦, 西宮健介, 白戸崇, 坂田泰彦, 齋木佳克, 下川宏明

脈管学(Web)　60　(supplement)　2020年

ISSN： 1880-8840
冠動脈疾患における新規予後予測バイオマーカーAdipsinの発見補体系を介した心筋梗塞発症予測の新たな展開

大槻知広, 佐藤公雄, 清水亨, 池田尚平, 菊地順裕, 佐藤大樹, 黒澤亮, 野木正道, 砂村慎一郎, 矢尾板信裕, 大村淳一, 杉村宏一郎, 青木竜男, 建部俊介, 高橋潤, 宮田敏, 下川宏明

血管　43　(1)　36-36　2020年1月
出版者・発行元：日本心脈管作動物質学会
ISSN： 0911-4637
Clinical Benefits of Antithrombotic Therapy in Patients With Atrial Fibrillation Comorbid With Heart Failure and Coronary Artery Disease - A Report From the Chart-2 Study -

Takashi Shiroto, Yasuhiko Sakata, Kotaro Nochioka, Ruri Abe, Shintaro Kasahara, Masayuki Sato, Hajime Aoyanagi, Takahide Fujihashi, Shinsuke Yamanaka, Hideka Hayashi, Masanobu Miura, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

CIRCULATION　140　2019年11月

ISSN： 0009-7322

eISSN： 1524-4539
Exercise Training Ameliorates Vasodilator Capacity of Coronary Microvessels in Patients With Vasospastic Angina -A New Therapeutic Approach for the Coronary Functional Disorder

Jun Sugisawa, Yasuharu Matsumoto, Akira Suda, Satoshi Tsuchiya, Kazuma Ohyama, Masashi Takeuchi, Kensuke Nishimiya, Mina Akizuki, Koichi Sato, Shoko Kajitani, Hideki Ota, Shohei Ikeda, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Yasuhiko Sakata, Kei Takase, Masahiro Kohzuki, Hiroaki Shimokawa

CIRCULATION　140　2019年11月

ISSN： 0009-7322

eISSN： 1524-4539
Prognostic Impacts of Dynamic Left Ventricular Structural Changes in Heart Failure Patients With Preserved Ejection Fraction -A Report From the CHART-2 Study-

Shinsuke Yamanaka, Yasuhiko Sakata, Kotaro Nochioka, Masanobu Miura, Shintaro Kasahara, Masayuki Sato, Hajime Aoyanagi, Takahide Fujihashi, Hideka Hayashi, Takashi Shiroto, Koichiro Sugimura, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

CIRCULATION　140　2019年11月

ISSN： 0009-7322

eISSN： 1524-4539
冠攣縮性狭心症患者における冠血流予備能と運動耐容能の関連

杉澤潤, 松本泰治, 羽尾清貴, 竹内雅史, 秋月三奈, 須田彬, 左藤公一, 土屋聡, 梶谷翔子, 進藤智彦, 菊地翼, 白戸崇, 高橋潤, 上月正博, 下川宏明

日本心臓病学会学術集会抄録　67回　O-063　2019年9月
出版者・発行元： (一社)日本心臓病学会
再開胸手術が困難とされたBentall手術後の左右冠動脈口と人工血管吻合部の高度狭窄にPCIを施行した大動脈炎症候群の一例

池田尚平, 高橋潤, 菊地翼, 須田彬, 進藤智彦, 羽尾清貴, 松本泰治, 吉岡一朗, 齋木佳克, 下川宏明

日本心血管インターベンション治療学会抄録集　28回　[MO61-004]　2019年9月
出版者・発行元： (一社)日本心血管インターベンション治療学会
PCI時代における冠動脈機能異常の重要性胸痛を有する非閉塞性冠動脈疾患患者における冠動脈機能異常に関する包括的評価

須田彬, 高橋潤, 羽尾清貴, 菊地翼, 進藤智彦, 池田尚平, 佐藤公一, 杉澤潤, 松本泰治, 宮田敏, 坂田泰彦, 下川宏明

日本心血管インターベンション治療学会抄録集　28回　[S28-2]　2019年9月
出版者・発行元： (一社)日本心血管インターベンション治療学会
再開胸手術が困難とされたBentall手術後の左右冠動脈口と人工血管吻合部の高度狭窄にPCIを施行した大動脈炎症候群の一例

池田尚平, 高橋潤, 菊地翼, 須田彬, 進藤智彦, 羽尾清貴, 松本泰治, 吉岡一朗, 齋木佳克, 下川宏明

日本心血管インターベンション治療学会抄録集　28回　[MO61-004]　2019年9月
出版者・発行元： (一社)日本心血管インターベンション治療学会
高齢大動脈弁狭窄症におけるTAVI術後せん妄はフレイル患者に多く半年後の低身体機能を予測する

竹内雅史, 松本泰治, 土屋聡, 杉澤潤, 羽尾清貴, 菊地翼, 高橋潤, 宮田敏, 上月正博, 齋木佳克, 下川宏明

日本循環器学会学術集会抄録集　83回　CP14-1　2019年3月
出版者・発行元： (一社)日本循環器学会
高齢大動脈弁狭窄症におけるTAVI術後せん妄はフレイル患者に多く半年後の低身体機能を予測する

竹内雅史, 松本泰治, 土屋聡, 杉澤潤, 羽尾清貴, 菊地翼, 高橋潤, 宮田敏, 上月正博, 齋木佳克, 下川宏明

日本循環器学会学術集会抄録集　83回　CP14-1　2019年3月
出版者・発行元： (一社)日本循環器学会
非ST上昇型心筋梗塞における性差の検討-宮城AMI登録研究からの報告-

佐藤公一, 高橋潤, 羽尾清貴, 須田彬, 進藤智彦, 菊地翼, 松本泰治, 宮田徹, 坂田泰彦, 下川宏明, 下川宏明

日本性差医学・医療学会学術集会プログラム・抄録集　12th　2019年
非閉塞性冠動脈疾患における冠動脈機能異常の包括的評価

須田彬, 高橋潤, 羽尾清貴, 菊地翼, 進藤智彦, 佐藤公一, 杉澤潤, 松本泰治, 宮田敏, 坂田泰彦, 下川宏明

脈管学(Web)　59　(supplement)　2019年

ISSN： 1880-8840
The Simple Risk Model for Heart Failure With Preserved Ejection Fraction-A Report From the CHART-2 Study

Shintaro Kasahara, Yasuhiko Sakata, Kotaro Nochioka, Ruri Abe, Masayuki Sato, Hajime Aoyanagi, Takahide Fujihashi, Shinsuke Yamanaka, Masanobu Miura, Takashi Shiroto, Jun Takahashi, Koichiro Sugimura, Satoshi Miyata, Hiroaki Shimokawa

CIRCULATION　138　2018年11月

ISSN： 0009-7322

eISSN： 1524-4539
Benefit and Risk of Antithrombotic Therapy in Patients With Atrial Fibrillation -A Report From the CHART-2 Study

Takashi Shiroto, Yasuhiko Sakata, Kotaro Nochioka, Ruri Abe, Takuya Oikawa, Shintaro Kasahara, Masayuki Sato, Hajime Aoyanagi, Shinsuke Yamanaka, Takahide Fujihashi, Masanobu Miura, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

CIRCULATION　138　2018年11月

ISSN： 0009-7322

eISSN： 1524-4539
Prognostic Impacts of Impaired Coronary Vasodilator Function and Enhanced Vasoconstriction Responses in Patients With Angina and Unobstructive Coronary Arteries

Akira Suda, Jun Takahashi, Kiyotaka Hao, Yoku Kikuchi, Tomohiko Shindo, Shohei Ikeda, Koichi Sato, Jun Sugisawa, Yasuharu Matsumoto, Satoshi Miyata, Yasuhiko Sakata, Hiroaki Shimokawa

CIRCULATION　138　2018年11月

ISSN： 0009-7322

eISSN： 1524-4539
Elevated Serum Triglyceride Level as a Significant Residual Risk for Acute Myocardial Infraction in Patients With Stable Ischemic Heart Disease Under Statin Treatment-A Report From the CHART-2 Study

Kota Suzuki, Takuya Oikawa, Kotaro Nochioka, Masanobu Miura, Ruri Abe, Shintaro Kasahara, Masayuki Sato, Hajime Aoyanagi, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Yasuhiko Sakata, Hiroaki Shimokawa

CIRCULATION　138　2018年11月

ISSN： 0009-7322

eISSN： 1524-4539
2014年版災害時循環器疾患の予防・管理に関するガイドライン

高橋潤, 下川宏明

救急医学　42　(10)　1289‐1294　2018年9月20日

ISSN： 0385-8162
Development of Useful Conversion Equation between B-type Natriuretic Peptide and N-terminal pro BNP Levels

Shintaro Kasahara, Yasuhiko Sakata, Kotaro Nochioka, Ruri Abe, Masayuki Sato, Hajime Aoyanagi, Masanobu Miura, Takashi Shiroto, Jun Takahashi, Koichiro Sugimura, Satoshi Miyata, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　24　(8)　S23-S23　2018年8月

DOI： 10.1016/j.cardfail.2018.07.068 　

ISSN： 1071-9164

eISSN： 1532-8414
冠血管反応の制御における心臓リンパ管の重要性―薬剤溶出性ステント留置後のブタモデルを用いた検討―

天水宏和, 松本泰治, 諸沢薦, 大山宗馬, 宇塚裕紀, 平野道基, 杉澤潤, 土屋聡, 佐藤公一, 須田彬, 進藤智彦, 池田尚平, 西宮健介, 菊地翼, 羽尾清貴, 白戸崇, 高橋潤, 林もゆる, 河合佳子, 下川宏明

リンパ学　41　(Supplement)　28　2018年5月7日

ISSN： 0910-4186
重度の大動脈弁狭窄を有する高齢患者におけるTAVI後の認知機能改善のエビデンス心臓-脳相互作用の関与(Evidence for Improved Cognitive Functions after TAVI in Elderly Patients with Severe Aortic Stenosis: Involvement of the Heart-Brain Interaction)

土屋聡, 松本泰治, 杉澤潤, 菊地翼, 高橋潤, 川本俊輔, 熊谷紀一郎, 齋木佳克, 下川宏明

日本循環器学会学術集会抄録集　82回　PJ042-3　2018年3月
出版者・発行元： (一社)日本循環器学会
重度の大動脈狭窄を有する高齢患者におけるTAVI後の認知機能改善のエビデンス心臓-脳相互作用の関与(Evidence for Improved Cognitive Functions after TAVI in Elderly Patients with Severe Aortic Stenosis: Involvement of the Heart-Brain Interaction)

土屋聡, 松本泰治, 杉澤潤, 菊地翼, 高橋潤, 川本俊輔, 熊谷紀一郎, 齋木佳克, 下川宏明

日本循環器学会学術集会抄録集　82回　PJ042-3　2018年3月
出版者・発行元： (一社)日本循環器学会
冠動脈過収縮反応における心臓リンパ管の重要性―ブタ動物モデルを用いた検討―

天水宏和, 松本泰治, 諸沢薦, 大山宗馬, 宇塚裕紀, 平野道基, 杉澤潤, 土屋聡, 佐藤公一, 須田彬, 進藤智彦, 池田尚平, 西宮健介, 菊地翼, 羽尾清貴, 白戸崇, 高橋潤, 下川宏明

血管　41　(1)　36　2018年1月31日

ISSN： 0911-4637
胸痛を伴う運動誘発性左脚ブロックの一例

進藤智彦, 高橋潤, 松本泰治, 白戸崇, 菊地翼, 羽尾清貴, 池田尚平, 須田彬, 杉澤潤, 土屋聡, 梶谷翔子, 佐藤公一, 下川宏明

日本循環器学会東北地方会(Web)　166th　2018年
急性心筋梗塞後に偽性仮性心室瘤と中隔穿孔を合併し,慢性期にパッチ閉鎖術と左室形成術を施行した一例

菊地翼, 佐藤公一, 杉澤潤, 土屋聡, 進藤智彦, 池田尚平, 羽尾清貴, 白戸崇, 松本泰治, 高橋潤, 下川宏明, 川本俊輔, 鈴木祐輔, 秋山正年, 齋木佳克, 伊藤愛剛, 井上寛一

日本循環器学会東北地方会(Web)　166th　2018年
東日本大震災が循環器疾患に及ぼした影響と性差

高橋潤

日本性差医学・医療学会学術集会プログラム・抄録集　11th　61　2018年
高齢心不全患者の臨床的特徴と予後規定因子における性差―CHART‐2研究からの報告―

佐藤雅之, 坂田泰彦, 及川卓也, 阿部瑠璃, 笠原信太郎, 後岡広太郎, 白戸崇, 高橋潤, 宮田敏, 下川宏明, 下川宏明

日本性差医学・医療学会学術集会プログラム・抄録集　11th　112　2018年
冠攣縮性狭心症患者における冠血流予備能と運動耐容能の関連

杉澤潤, 松本泰治, 羽尾清貴, 須田彬, 竹内雅史, 土屋聡, 佐藤公一, 進藤智彦, 池田尚平, 菊地翼, 高橋潤, 下川宏明

日本臨床運動療法学会雑誌　20　(1)　69　2018年
非閉塞性冠動脈を伴う心筋梗塞(MINOCA)患者の臨床像―宮城県AMI登録研究―

羽尾清貴, 高橋潤, 佐藤公一, 進藤智彦, 池田尚平, 菊地翼, 松本泰治, 宮田敏, 坂田泰彦, 下川宏明, 下川宏明

日本性差医学・医療学会学術集会プログラム・抄録集　11th　111　2018年
心不全発症高リスク患者における左室駆出率の経時的変化の性差

青柳肇, 坂田泰彦, 後岡広太郎, 白戸崇, 及川卓也, 阿部瑠璃, 笠原信太郎, 高橋潤, 宮田敏, 下川宏明, 下川宏明

日本性差医学・医療学会学術集会プログラム・抄録集　11th　105　2018年
BNPとNT‐proBNPの相関における性差

笠原信太郎, 坂田泰彦, 後岡広太郎, 阿部瑠璃, 及川卓也, 佐藤雅之, 白戸崇, 高橋潤, 宮田敏, 下川宏明, 下川宏明

日本性差医学・医療学会学術集会プログラム・抄録集　11th　113　2018年
高齢急性心筋梗塞患者におけるプライマリー冠動脈インターベンション治療効果の性差に関する検討

佐藤公一, 高橋潤, 羽尾清貴, 進藤智彦, 池田尚平, 菊地翼, 松本泰治, 宮田敏, 坂田泰彦, 下川宏明, 下川宏明

日本性差医学・医療学会学術集会プログラム・抄録集　11th　104　2018年
循環器治療薬 8 冠拡張薬

高橋潤, 下川宏明

レジデント　10　(6)　64‐71　2017年12月1日
Temporal Trends in Emergency Care and Outcomes of Geriatric Patients With Acute Myocardial Infarction in Japan -A Report From the Miyagi AMI Registry Study

Koichi Sato, Jun Takahashi, Yuanji Cui, Kiyotaka Hao, Satoshi Miyata, Yasuhiko Sakata, Hiroaki Shimokawa

CIRCULATION　136　2017年11月

ISSN： 0009-7322

eISSN： 1524-4539
Evidence for Enhanced Inflammation of Coronary Adventitia and Perivascular Adipose Tissue With Altered Disease Activity in Vasospastic Angina Patients -A Multi-modality Imaging Study

Kazuma Ohyama, Yasuharu Matsumoto, Kentaro Takanami, Hideki Ota, Kensuke Nishimiya, Jun Sugisawa, Satoshi Tsuchiya, Hirokazu Amamizu, Hironori Uzuka, Akira Suda, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Jun Takahashi, Yasuhiko Sakata, Hiroaki Shimokawa

CIRCULATION　136　2017年11月

ISSN： 0009-7322

eISSN： 1524-4539
Sex Differences in Coronary Microvascular Dysfunction in Patients With Vasospastic Angina

Akira Suda, Jun Takahashi, Kiyotaka Hao, Yoku Kikuchi, Tomohiko Shindo, Yasuharu Matsumoto, Yasuhiko Sakata, Hiroaki Shimokawa

CIRCULATION　136　2017年11月

ISSN： 0009-7322

eISSN： 1524-4539
A Simple Risk Score to Predict Mortality for Patients With Heart Failure With Preserved Ejection Fraction - A Report From the CHART-2 Study-

Shintaro Kasahara, Yasuhiko Sakata, Kotaro Nochioka, Ruri Abe, Takuya Oikawa, Masayuki Sato, Hajime Aoyanagi, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

CIRCULATION　136　2017年11月

ISSN： 0009-7322

eISSN： 1524-4539
A Simple Risk Score to Predict Mortality for Patients With Heart Failure With Preserved Ejection Fraction - A Report From the CHART-2 Study

Shintaro Kasahara, Yasuhiko Sakata, Kotaro Nochioka, Ruri Abe, Takuya Oikawa, Masayuki Sato, Hajime Aoyanagi, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

CIRCULATION　136　2017年11月

ISSN： 0009-7322

eISSN： 1524-4539
Microalbuminuria, Impaired Glucose Tolerance, and Their Prognostic Implications in Patients With Chronic Heart Failure: Insights From the SUPPlemental Benefit of an Angiotensin Receptor Blocker in Hypertensive Patients With Stable Heart Failure Using OlmesaRTan (SUPPORT) Trial

Kotaro Nochioka, Yasuhiko Sakata, Takuya Oikawa, Ruri Abe, Shintaro Kasahara, Masayuki Sato, Hajime Aoyanagi, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

CIRCULATION　136　2017年11月

ISSN： 0009-7322

eISSN： 1524-4539
Increased Risk of Cancer Death in Patients With Chronic Heart Failure -A Report From the CHART-2 Study-

Takuya Oikawa, Yasuhiko Sakata, Kotaro Nochioka, Masanobu Miura, Ruri Abe, Shintaro Kasahara, Masayuki Sato, Hajime Aoyanagi, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

CIRCULATION　136　2017年11月

ISSN： 0009-7322

eISSN： 1524-4539
Prognosis and Prognostic Factors of Elderly Patients With Chronic Heart Failure: A Report From the CHART 2 Study

Masayuki Sato, Yasuhiko Sakata, Takuya Oikawa, Ruri Abe, Shintaro Kasahara, Hajime Aoyanagi, Masanobu Miura, Kotaro Nochioka, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

CIRCULATION　136　2017年11月

ISSN： 0009-7322

eISSN： 1524-4539
Prognostic Impacts of Antithrombotic Therapies in Patients With Atrial Fibrillation -Report From the CHART-2 Study-

Takashi Shiroto, Yasuhiko Sakata, Kotaro Nochioka, Ruri Abe, Takuya Oikawa, Shintaro Kasahara, Masayuki Sato, Hajime Aoyanagi, Masanobu Miura, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

CIRCULATION　136　2017年11月

ISSN： 0009-7322

eISSN： 1524-4539
動脈・静脈の疾患(臓器別)虚血性心疾患内科治療

高橋潤, 下川宏明

日本臨床　75　566‐570　2017年7月20日

ISSN： 0047-1852
¹⁸F‐FDG PETを用いた冠動脈周囲脂肪組織の炎症性変化の検討―薬剤溶出性ステント留置後のブタ冠動脈過収縮モデルを用いて―

大山宗馬, 松本泰治, 天水宏和, 宇塚裕紀, 西宮健介, 諸沢薦, 平野道基, 渡部浩司, 渡部浩司, 船木善仁, 高橋潤, 伊藤健太, 下川弘明

心臓核医学　19　(2)　15　2017年6月2日

ISSN： 1346-2733
Comparable prognostic impacts of plasma B-type natriuretic peptide levels among patients with heart failure with preserved, mid-range and reduced left ventricular ejection fraction

S. Kasahara, Y. Sakata, K. Nochioka, K. Tsuji, R. Abe, T. Oikawa, M. Sato, T. Shiroto, J. Takahashi, S. Miyata, H. Shimokawa

EUROPEAN JOURNAL OF HEART FAILURE　19　475-475　2017年5月

ISSN： 1388-9842

eISSN： 1879-0844
80歳以上の心筋梗塞症例に対する冠動脈インターベンションの治療成績:JAMIR解析結果から

西平賢作, 小島淳, 高山守正, 竹上未紗, 中尾葉子, 本田怜史, 高橋潤, 住吉徹哉, 木村一雄, 安田聡

日本心血管脳卒中学会学術集会プログラム・抄録集　4th　88　2017年4月24日
経カテーテル大動脈弁留置術に対する継続的なフレイルガイドのリハビリテーションは、術後回復レベルを予測し、在宅期のQOLとフレイルを改善する

竹内雅史, 松本泰治, 川本俊輔, 高橋潤, 青木竜男, 杉村宏一郎, 宮田敏, 上月正博, 荒井啓行, 齋木佳克, 下川宏明

日本循環器学会学術集会抄録集　81回　CP-236　2017年3月
出版者・発行元： (一社)日本循環器学会
臨床的背景に基づいた初発心房細動の予測モデルの確立 CHART-2および久山研究からの見識(Establishment of Predictive Models of New-onset Atrial Fibrillation Based on Clinical Background: Insights from the CHART-2 and the Hisayama Studies)

坂田泰彦, 山内毅, 後岡広太郎, 白戸崇, 小野瀬剛生, 辻薫菜子, 阿部瑠璃, 及川卓也, 笠原信太郎, 佐藤雅之, 三浦正暢, 高橋潤, 宮田敏, 二宮利治, 下川宏明

日本循環器学会学術集会抄録集　81回　LBCS4-1　2017年3月
出版者・発行元： (一社)日本循環器学会
耐糖能障害を呈する慢性心不全における微量アルブミン尿と予後との関連薬物介入研究SUPPORT試験からの知見

後岡広太郎, 坂田泰彦, 宮田敏, 三浦正暢, 白戸崇, 高橋潤, 柴信行, 下川宏明

日本内科学会雑誌　106　(Suppl.)　165-165　2017年2月
出版者・発行元： (一社)日本内科学会
ISSN： 0021-5384

eISSN： 1883-2083
性差医学・医療の進歩と臨床展開 Vol.1 わが国における性差医療の現状

高橋潤, 下川宏明

医学のあゆみ　260　(2)　177‐182　2017年1月14日

ISSN： 0039-2359
当院における植込み型左心補助人工心臓50例の成績

秋山正年, 河津聡, 吉岡一朗, 安達理, 熊谷紀一郎, 高橋潤, 杉村宏一郎, 青木竜男, 川本俊輔, 下川宏明, 齋木佳克

日本循環器学会東北地方会(Web)　164th　2017年
急性心不全発症を契機に発見された巨大左室内血栓の1例

杉澤潤, 菊地翼, 土屋聡, 佐藤公一, 照井洋輔, 青柳肇, 進藤智彦, 池田尚平, 羽尾清貴, 白戸崇, 松本泰治, 高橋潤, 坂田泰彦, 河津聡, 川本俊輔, 齋木佳克, 下川宏明

日本循環器学会東北地方会(Web)　165th　2017年
Valsalva洞径から検討した経カテーテル的大動脈弁置換術(TAVI)deviceの選択-当院における経験-

土屋聡, 松本泰治, 菊地翼, 杉澤潤, 羽尾清貴, 高橋潤, 川本俊輔, 熊谷紀一郎, 齋木佳克, 下川宏明

日本循環器学会東北地方会(Web)　164th　2017年
TAVIによりvWF高分子量多量体欠損の改善と毛細血管拡張症の消退を認めたHeyde症候群の一例

土屋聡, 松本泰治, 菊地翼, 杉澤潤, 進藤智彦, 池田尚平, 羽尾清貴, 高橋潤, 川本俊輔, 熊谷紀一郎, 堀内久徳, 齋木佳克, 下川宏明

日本循環器学会東北地方会(Web)　165th　2017年
TAVI術前と慢性期における高齢者フレイル評価:TAVI術後せん妄の予測とフレイルガイド病診連携の重要性

竹内雅史, 竹内雅史, 松本泰治, 川本俊輔, 土屋聡, 高橋潤, 宮田敏, 上月正博, 荒井啓行, 齋木佳克, 下川宏明

日本心不全学会学術集会プログラム・抄録集　21st　387　2017年
冠循環機能異常における性差

高橋潤, 須田彬, 下川宏明

日本性差医学・医療学会学術集会プログラム・抄録集　10th　56　2017年
Prognostic Impact of and Risk Score for the Onset of Atrial Fibrillation in Patients at High Risk for Heart Failure -A Report From the CHART-2 Study

Takeshi Yamauchi, Yasuhiko Sakata, Masanobu Miura, Takeo Onose, Kanako Tsuji, Ruri Abe, Takuya Oikawa, Shintaro Kasahara, Kotaro Nochioka, Jun Takahashi, Takashi Shiroto, Satoshi Miyata, Hiroaki Shimokawa

CIRCULATION　134　2016年11月

ISSN： 0009-7322

eISSN： 1524-4539
Prognostic Impact of and Risk Score for the Onset of Atrial Fibrillation in Patients at High Risk for Heart Failure -A Report From the CHART-2 Study

Takeshi Yamauchi, Yasuhiko Sakata, Masanobu Miura, Takeo Onose, Kanako Tsuji, Ruri Abe, Takuya Oikawa, Shintaro Kasahara, Kotaro Nochioka, Jun Takahashi, Takashi Shiroto, Satoshi Miyata, Hiroaki Shimokawa

CIRCULATION　134　2016年11月

ISSN： 0009-7322

eISSN： 1524-4539
Evidence for Involvement of Inflammatory Changes of Perivascular Adipose Tissue in the Pathogenesis of Coronary Hyperconstricting Responses Induced by Drug-Eluting Stent in Pigs in vivo - Impact of Fluorodeoxyglucose Positron Emission Tomography Imaging

Kazuma Ohyama, Yasuharu Matsumoto, Hirokazu Amamizu, Hironori Uzuka, Kensuke Nishimiya, Susumu Morosawa, Michinori Hirano, Hiroshi Watabe, Yoshihito Funaki, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa

CIRCULATION　134　2016年11月

ISSN： 0009-7322

eISSN： 1524-4539
Usefulness of Dual Induction Tests for Coronary Artery Spasm and Lethal Ventricular Arrhythmias in Patients Surviving Out-of-Hospital Cardiac Arrest

Masayasu Komatsu, Jun Takahashi, Makoto Nakano, Masateru Kondo, Ryuji Tsuburaya, Kiyotaka Hao, Kensuke Nishimiya, Taro Nihei, Yasuharu Matsumoto, Kenta Ito, Koji Fukuda, Hiroaki Shimokawa

CIRCULATION　134　2016年11月

ISSN： 0009-7322

eISSN： 1524-4539
Comparable Prognostic Impacts of B-type Natriuretic Peptide Levels bBetween Heart Failure With Reduced and Preserved Ejection Fraction - a Report From the CHART-2 Study

Shintaro Kasahara, Yasuhiko Sakata, Takeshi Yamauchi, Takeo Onose, Kanako Tsuji, Ruri Abe, Takuya Oikawa, Masayuki Sato, Kotaro Nochioka, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

CIRCULATION　134　2016年11月

ISSN： 0009-7322

eISSN： 1524-4539
Evidence for Involvement of Inflammatory Changes of Perivascular Adipose Tissue in the Pathogenesis of Coronary Hyperconstricting Responses Induced by Drug-Eluting Stent in Pigs in vivo -Impact of Fluorodeoxyglucose Positron Emission Tomography Imaging

Kazuma Ohyama, Yasuharu Matsumoto, Hirokazu Amamizu, Hironori Uzuka, Kensuke Nishimiya, Susumu Morosawa, Michinori Hirano, Hiroshi Watabe, Yoshihito Funaki, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa

CIRCULATION　134　2016年11月

ISSN： 0009-7322

eISSN： 1524-4539
Comparable Prognostic Impacts of B-type Natriuretic Peptide Levels bBetween Heart Failure With Reduced and Preserved Ejection Fraction -a Report From the CHART-2 Study

Shintaro Kasahara, Yasuhiko Sakata, Takeshi Yamauchi, Takeo Onose, Kanako Tsuji, Ruri Abe, Takuya Oikawa, Masayuki Sato, Kotaro Nochioka, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

CIRCULATION　134　2016年11月

ISSN： 0009-7322

eISSN： 1524-4539
冠動脈インターベンション最近の知見―非心臓手術前のPCI適応に関して―

高橋潤

日本手術看護学会誌　12　(2)　118　2016年9月30日

ISSN： 1880-4780
Prognostic Impact of Residual Coronary Stenosis in Patients With Ischemic Heart Failure After Percutaneous Coronary Intervention

Kiyotaka Hao, Jun Takahashi, Satoshi Miyata, Yasuhiko Sakata, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　22　(9)　S156-S156　2016年9月

DOI： 10.1016/j.cardfail.2016.07.026 　

ISSN： 1071-9164

eISSN： 1532-8414
Clinical Features of Patients with Heart Failure with Preserved Ejection Fraction-A Report from the CHART-2 Study-

Kanako Tsuji, Yasuhiko Sakata, Masanobu Miura, Satoshi Miyata, Kotaro Nochioka, Takeshi Yamauchi, Take Onose, Takashi Shiroto, Jun Takahashi, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　22　(9)　S165-S165　2016年9月

DOI： 10.1016/j.cardfail.2016.07.075 　

ISSN： 1071-9164

eISSN： 1532-8414
Influence of Stalin Intensity on Prognostic Impacts in Patients with Ischemic Heart Failure-A Report From the CHART-2 Study-

Takuya Oikawa, Yasuhiko Sakata, Takeshi Yamauchi, Kanako Tsuji, Takeo Onose, Shintaro Kasahara, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　22　(9)　S172-S172　2016年9月

DOI： 10.1016/j.cardfail.2016.07.108 　

ISSN： 1071-9164

eISSN： 1532-8414
Prognostic risk stratification with plasma B-type natriuretic peptide levels in patients with chronic heart failure - a report from the CHART-2 Study

S. Kasahara, Y. Sakata, M. Miura, S. Tadaki, K. Tsuji, T. Yamauchi, R. Abe, T. Oikawa, J. Takahashi, S. Miyata, H. Shimokawa

EUROPEAN HEART JOURNAL　37　1326-1327　2016年8月

ISSN： 0195-668X

eISSN： 1522-9645
Prognostic impact of residual coronary stenosis in patients with ischemic heart failure after percutaneous coronary intervention a report from the CHART-2 study

K. Hao, J. Takahashi, Y. Sakata, S. Miyata, M. Miura, H. Shimokawa

EUROPEAN HEART JOURNAL　37　320-320　2016年8月

ISSN： 0195-668X

eISSN： 1522-9645
Renal denervation suppresses coronary hyperconstricting responses after DES implantation in pigs in vivo - evidence for the kidney-brain-heart interactions

H. Uzuka, Y. Matsumoto, K. Ohyama, K. Nishimiya, H. Amamizu, S. Morosawa, M. Hirano, K. Hao, R. Tsuburaya, K. Ito, J. Takahashi, Y. Funaki, H. Watabe, H. Shimokawa

EUROPEAN HEART JOURNAL　37　1003-1004　2016年8月

ISSN： 0195-668X

eISSN： 1522-9645
Differences in Clinical Characteristics and Prognosis between Heart Failure with Preserved Ejection Fraction and That with Reduced Ejection Fraction -Insights From the CHART-2 Study

Kanako Tsuji, Yasuhiko Sakata, Masanobu Miura, Satoshi Miyata, Kotaro Nochioka, Soichiro Tadaki, Takeshi Yamauchi, Take Onose, Ruri Abe, Takuya Oikawa, Shintaro Kasahara, Jun Takahashi, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　22　(8)　S64-S64　2016年8月

DOI： 10.1016/j.cardfail.2016.06.203 　

ISSN： 1071-9164

eISSN： 1532-8414
Evidence for involvement of inflammatory changes of perivascular adipose tissue in the pathogenesis of DES-induced hyperconstricting responses in pigs in vivo - impact of 18F-FDG PET imaging

K. Ohyama, Y. Matsumoto, H. Amamizu, H. Uzuka, K. Nishimiya, S. Morosawa, M. Hirano, H. Watabe, Y. Funaki, J. Takahashi, K. Ito, H. Shimokawa

EUROPEAN HEART JOURNAL　37　786-786　2016年8月

ISSN： 0195-668X

eISSN： 1522-9645
急性心筋梗塞発症率及び院内死亡率の経年変化に関する検討 Miyagi AMI Registry Study(1985-2014)からの報告

崔元吉, 羽尾清貴, 高橋潤, 伊藤健太, 宮田敏, 西宮健介, 圓谷隆治, 松本泰治, 坂田泰彦, 下川宏明

日本内科学会雑誌　105　(Suppl.)　157-157　2016年2月
出版者・発行元： (一社)日本内科学会
ISSN： 0021-5384

eISSN： 1883-2083
経カテーテル大動脈弁留置術における心臓リハビリテーション-理学療法士の立場から「フレイル」を認識し対応する重要性-

竹内雅史, 竹内雅史, 松本泰治, 森信芳, 高橋潤, 杉村宏一郎, 三浦正暢, 川本俊輔, 熊谷紀一郎, 上月正博, 上月正博, 齋木佳克, 下川宏明

日本心臓病学会学術集会(Web)　64th　2016年
低心機能を伴った重症大動脈弁狭窄症に人工心肺サポート下でTAVIを施行した2例

土屋聡, 松本泰治, 高橋潤, 杉村宏一郎, 菊地翼, 羽尾清貴, 進藤智彦, 須田彬, 杉澤潤, 熊谷紀一郎, 川本俊輔, 齋木佳克, 下川宏明

日本循環器学会東北地方会(Web)　163rd　2016年
血漿中Adipsin濃度による冠動脈疾患の長期予後予測

大槻知広, 佐藤公雄, 杉村宏一郎, 青木竜男, 建部俊介, 三浦正暢, 山本沙織, 矢尾板信裕, 鈴木秀明, 佐藤遥, 神津克也, 二瓶太郎, 高橋潤, 宮田敏, 下川宏明

日本心臓病学会学術集会(Web)　64th　ROMBUNNO.O‐085 (WEB ONLY)-085　2016年
出版者・発行元： (一社)日本心臓病学会
血漿中Cyclophilin Aによる冠動脈疾患の長期予後予測

大槻知広, 佐藤公雄, 杉村宏一郎, 青木竜男, 建部俊介, 三浦正暢, 山本沙織, 矢尾板信裕, 鈴木秀明, 佐藤遥, 神津克也, 二瓶太郎, 高橋潤, 宮田敏, 下川宏明

日本心臓病学会学術集会(Web)　64th　ROMBUNNO.O‐084 (WEB ONLY)-084　2016年
出版者・発行元： (一社)日本心臓病学会
心室細動で発症し冠攣縮性狭心症と肺高血圧症を合併した好酸球性多発血管炎性肉芽腫症(EGPA)の1例

紺野亮, 建部俊介, 杉村宏一郎, 青木竜男, 山本沙織, 矢尾板信裕, 佐藤遥, 神津克也, 羽尾清貴, 高橋潤, 中野誠, 福田浩二, 白井剛志, 杉浦久敏, 中嶋壮太, 石井智徳, 下川宏明

日本循環器学会東北地方会(Web)　163rd　TOHOKU163,4 (WEB ONLY)　2016年
心サルコイドーシスに冠攣縮性狭心症を合併した2症例

崔元吉, 羽尾清貴, 西宮健介, 圓谷隆治, 松本泰治, 高橋潤, 伊藤健太, 下川宏明

日本循環器学会東北地方会(Web)　162nd　TOHOKU162,28 (WEB ONLY)　2016年
Hybrid手術室において集約的加療を要した「たこつぼ型心筋症」の一例

須田彬, 西宮健介, 圓谷隆治, 羽尾清貴, 松本泰治, 高橋潤, 伊藤健太, 佐藤英昭, 森川孝則, 海野倫明, 下川宏明

日本循環器学会東北地方会(Web)　162nd　TOHOKU162,12 (WEB ONLY)　2016年
血漿セロトニン濃度は冠微小血管障害を反映する

小鷹悠二, 高橋潤, 圓谷隆治, 羽尾清貴, 西宮健介, 須田彬, 小松真恭, 松本泰治, 伊藤健太, 下川宏明

日本循環器学会東北地方会(Web)　162nd　TOHOKU162,9 (WEB ONLY)　2016年
冠微小血管障害と血漿セロトニン濃度

小鷹悠二, 高橋潤, 圓谷隆治, 羽尾清貴, 西宮健介, 須田彬, 小松真恭, 松本泰治, 伊藤健太, 下川宏明

日本心臓病学会学術集会(Web)　64th　ROMBUNNO.S8‐5 (WEB ONLY)　2016年
Increased Coronary Perivascular Adipose Tissue Volume on Cardiac Computed Tomography in Patients With Vasospastic Angina-Possible Correlation With Adventitial Vasa Vasorum Formation

Kazuma Ohyama, Yasuharu Matsumoto, Hirokazu Amamizu, Hironori Uzuka, Kensuke Nishimiya, Kiyotaka Hao, Ryuji Tsuburaya, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa

CIRCULATION　132　2015年11月

ISSN： 0009-7322

eISSN： 1524-4539
Temporal Trends in Incidence and Mortality of Acute Myocardial Infarction for 30 Years in Japan -A Report From the Miyagi AMI Registry Study

Yuanji Cui, Kiyotaka Hao, Jun Takahashi, Satoshi Miyata, Ryuji Tsuburaya, Yasuharu Matsumoto, Kenta Ito, Yasuhiko Sakata, Hiroaki Shimokawa

CIRCULATION　132　2015年11月

ISSN： 0009-7322

eISSN： 1524-4539
Clinical Characteristics of Patients With Acute Myocardial Infarction Who Did Not Receive Primary Percutaneous Coronary Intervention in Japan -Report From the Miyagi-AMI Registry Study

Kiyotaka Hao, Jun Takahashi, Kenta Ito, Yuanji Cui, Satoshi Miyata, Kensuke Nishimiya, Ryuji Tsuburaya, Yasuharu Matsumoto, Yasuhiko Sakata, Satoshi Yasuda, Hiroaki Shimokawa

CIRCULATION　132　2015年11月

ISSN： 0009-7322

eISSN： 1524-4539
Association of Enhanced Adventitial Vasa Vasorum Formation With Atherosclerotic Changes in the Human Coronary Arteries Adjacent to Myocardial Bridging -An Optical Frequency Domain Imaging Study

Hongxin Wang, Yasuharu Matsumoto, Kensuke Nishimiya, Jun Takahashi, Hironori Uzuka, Kiyotaka Hao, Ryuji Tsuburaya, Hirokazu Amamizu, Kazuma Ohyama, Masayasu Komatsu, Yuji Odaka, Kenta Ito, Hiroaki Shimokawa

CIRCULATION　132　2015年11月

ISSN： 0009-7322

eISSN： 1524-4539
Beneficial Effects of Long-acting Nifedipine on Coronary Vasomotion Abnormalities After Drug-Eluting Stent Implantation -The NOVEL Study

Ryuji Tsuburaya, Jun Takahashi, Akihiro Nakamura, Eiji Nozaki, Masafumi Sugi, Yoshito Yamamoto, Tetsuya Hiramoto, Satoru Horiguchi, Kanichi Inoue, Toshikazu Goto, Atsushi Kato, Tsuyoshi Shinozaki, Hiroaki Shimokawa

CIRCULATION　132　2015年11月

ISSN： 0009-7322

eISSN： 1524-4539
Involvement of Enhanced Inflammatory Changes in the Perivascular Adipose Tissue in the Pathogenesis of Coronary Hyperconstricting Responses After Drug-Eluting Stent Implantation in Pigs in vivo

Kazuma Ohyama, Yasuharu Matsumoto, Hirokazu Amamizu, Hironori Uzuka, Kensuke Nishimiya, Michinori Hirano, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa

CIRCULATION　132　2015年11月

ISSN： 0009-7322

eISSN： 1524-4539
Takotsubo Cardiomyopathy in a Case of Recurrent Pheochromocytoma

Ryuzaburo Kochi, Tatsuo Aoki, Koichiro Sugimura, Shunsuke Tatebe, Masanobu Miura, Nobuhiro Yaoita, Jun Takahashi, Yasuharu Matsumoto, Kimio Satou, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　21　(10)　S169-S170　2015年10月

ISSN： 1071-9164

eISSN： 1532-8414
The Supplemental Benefit of an Angiotensin Receptor Blocker in Hypertensive Patients with Stable Heart Failure Using Olmesartan (SUPPORT) Trial

Masanobu Miura, Yasuhiko Sakata, Satoshi Miyata, Soichiro Tadaki, Ryoichi Ushigome, Takeshi Yamauchi, Kenjiro Sato, Kotaro Nochioka, Jun Takahashi, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　21　(10)　S159-S159　2015年10月

DOI： 10.1016/j.cardfail.2015.08.086 　

ISSN： 1071-9164

eISSN： 1532-8414
Evidence for Brain Activation in Patients with Takotsubo Cardiomyopathy A New Finding of Cardio-Cerebral Connection

Hideaki Suzuki, Yasuharu Matsumoto, Kouichirou Sugimura, Jun Takahashi, Yoshihiro Fukumoto, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　21　(10)　S169-S169　2015年10月

ISSN： 1071-9164

eISSN： 1532-8414
冠微小循環障害と血中セロトニンの関連の検討

小鷹悠二, 高橋潤, 須田彬, 小松真恭, 西宮健介, 羽尾清貴, 円谷隆治, 松本泰治, 伊藤健太, 下川宏明

脈管学　55　(Suppl.)　S137-S137　2015年10月
出版者・発行元： (一社)日本脈管学会
ISSN： 0387-1126
Impact of long-acting nifedipine on coronary vascular function after drug-eluting stent implantation - The NOVEL study

R. Tsuburaya, J. Takahashi, E. Nozaki, M. Sugi, T. Hiramoto, S. Horiguchi, K. Inoue, T. Goto, A. Kato, H. Shimokawa

EUROPEAN HEART JOURNAL　36　1059-1060　2015年8月

ISSN： 0195-668X

eISSN： 1522-9645
Plasma levels of serotonin as a novel biomarker for coronary microvascular dysfunction in patient with vasospastic angina

Y. Odaka, J. Takahashi, R. Tuburaya, K. Nishimiya, K. Hao, Y. Matsumoto, Y. Hirowatari, H. Shimokawa

EUROPEAN HEART JOURNAL　36　295-295　2015年8月

ISSN： 0195-668X

eISSN： 1522-9645
Clinical Profiles and Prognostic Factors in the Elderly Patients with Heart Failure in Japan - A Report from the CHART-2 Study

Kenjiro Sato, Yasuhiko Sakata, Satoshi Miyata, Masanobu Miura, Soichiro Tadaki, Ryoichi Ushigome, Takeshi Yamauhi, Takeo Onose, Kanako Tsuji, Ruri Abe, Kotaro Nochioka, Jun Takahashi, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　21　(8)　S53-S53　2015年8月

DOI： 10.1016/j.cardfail.2015.06.175 　

ISSN： 1071-9164

eISSN： 1532-8414
Prognostic Impacts and Temporal Changes of Post-Traumatic Stress Disorder after the Great East Japan Earthquake in Patients with Heart Failure - A Report from the CHART-2 Study

Takeo Onose, Yasuhiko Sakata, Masanobu Miura, Soichiro Tadaki, Ryoichi Ushigome, Takeshi Yamauchi, Kenjiro Sato, Kanako Tsuji, Ruri Abe, Kotaro Nochioka, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　21　(8)　S53-S53　2015年8月

DOI： 10.1016/j.cardfail.2015.06.174 　

ISSN： 1071-9164

eISSN： 1532-8414
Enhanced inflammatory changes in the perivascular adipose tissue and coronary hyperconstricting responses after drug-eluting stent implantation in pigs in vivo

K. Ohyama, Y. Matsumoto, H. Uzuka, K. Nishimiya, M. Hirano, M. Kumagai, J. Takahashi, K. Ito, H. Shimokawa

EUROPEAN HEART JOURNAL　36　130-130　2015年8月

ISSN： 0195-668X

eISSN： 1522-9645
冠動脈攣縮の成因における外膜の役割

西宮健介, 松本泰治, 宇塚裕紀, 大山宗馬, 進藤智彦, 平野道基, 小鷹悠二, 羽尾清貴, 圓谷隆治, 高橋潤, 伊藤健太, 下川宏明

日本動脈硬化学会総会・学術集会プログラム・抄録集(Web)　47th　131 (WEB ONLY)　2015年6月25日
3.心臓病学研究の進歩(循環器学2014年の進歩)

高橋潤, 坂田泰彦, 松本泰治, 下川宏明

循環器専門医 : 日本循環器学会専門医誌　23　(1)　91-96　2015年3月25日
出版者・発行元：社団法人日本循環器学会
ISSN： 0918-9599
Airflow Limitation Is More Prevalent In Patients With Coronary Atherosclerosis Compared With General Population

T. Komaru, H. Kato, C. Takahashi, K. -Y. Saji, M. Miura

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　191　2015年

ISSN： 1073-449X

eISSN： 1535-4970
シンポジウム低出力体外衝撃波治療と心臓リハビリテーション

伊藤健太, 松本泰治, 高橋潤, 下川宏明

心臓リハビリテーション = Official journal of the Japanese Association of Cardiac Rehabilitation : 日本心臓リハビリテーション学会誌　20　(2)　323-325　2015年
出版者・発行元：日本心臓リハビリテーション学会 ; [1996]-
当院補助人工心臓センター開設までの経緯から振り返る重症心不全治療チーム体制の構築

秋山正年, 片平晋太郎, 河津聡, 藤原英記, 川本俊輔, 杉村宏一郎, 福田浩二, 高橋潤, 下川宏明, 齋木佳克

人工臓器(日本人工臓器学会)　44　(2)　2015年

ISSN： 0300-0818
拡張相肥大型心筋症に対する機械的補助循環治療の治療戦略の検討

秋山正年, 片平晋太郎, 河津聡, 渡邊晃佑, 高原真吾, 藤原英記, 安達理, 熊谷紀一郎, 川本俊輔, 青木竜男, 福田浩二, 高橋潤, 杉村宏一郎, 下川宏明, 齋木佳克

日本循環器学会東北地方会(Web)　160th　2015年
酸化ストレス分泌蛋白サイクロフィリンAは冠動脈疾患の長期予後を予測する

大槻知広, 佐藤公雄, 杉村宏一郎, 青木竜男, 建部俊介, 二瓶太郎, 高橋潤, 宮田敏, 下川宏明

日本酸化ストレス学会学術集会プログラム・抄録集　68th　2015年
たこつぼ型心筋症様の収縮障害を来たした褐色細胞腫の一例

古知龍三郎, 青木竜男, 杉村宏一郎, 建部俊介, 三浦正暢, 矢尾板信裕, 佐藤遥, 高橋潤, 松本泰治, 羽尾清貴, 佐藤公雄, 下川宏明

日本循環器学会東北地方会(Web)　160th　TOHOKU160,28 (WEB ONLY)　2015年
血漿中サイクロフィリンAによる冠動脈疾患の長期予後予測

大槻知広, 佐藤公雄, 杉村宏一郎, 青木竜男, 建部俊介, 三浦正暢, 山本沙織, 矢尾板信裕, 鈴木秀明, 佐藤遥, 神津克也, 二瓶太郎, 高橋潤, 宮田敏, 下川宏明

日本心臓病学会学術集会(Web)　63rd　ROMBUNNO.O‐163 (WEB ONLY)-797　2015年
出版者・発行元： (一社)日本心臓病学会
急性心筋梗塞発症率と院内死亡率の経年変化における性差の検討―MIYAGI‐AMI Registry Studyからの報告―

羽尾清貴, 高橋潤, 伊藤健太, 崔元吉, 宮田敏, 西宮健介, 圓谷隆治, 松本泰治, 坂田泰彦, 下川宏明

日本性差医学・医療学会学術集会プログラム・抄録集　8th　65　2015年
閉塞性肥大型心筋症にたこつぼ型心筋症を併発した肺移植症例

西宮健介, 羽尾清貴, 圓谷隆治, 松本泰治, 高橋潤, 伊藤健太, 渡邊龍秋, 星川康, 岡田克典, 下川宏明

日本循環器学会東北地方会(Web)　160th　TOHOKU160,62 (WEB ONLY)　2015年
乳酸アシドーシスを合併した非ST上昇型心筋梗塞の一例

圓谷隆治, 高橋潤, 西宮健介, 羽尾清貴, 松本泰治, 伊藤健太, 下川宏明

日本循環器学会東北地方会(Web)　160th　TOHOKU160,52 (WEB ONLY)　2015年
外傷性くも膜下出血と急性心筋梗塞を合併した一例

須田彬, 高橋潤, 神戸茂雄, 宮川乃理子, 西宮健介, 羽尾清貴, 圓谷隆治, 松本泰治, 久志本成樹, 下川宏明

日本循環器学会東北地方会(Web)　161st　TOHOKU161,53 (WEB ONLY)　2015年
心疾患におけるストレス・うつとの関わり:たこつぼ心筋症・心不全患者からの知見

松本泰治, 鈴木秀明, 西宮健介, 高橋潤, 杉村宏一郎, 古川勝敏, 荒井啓行, 下川宏明

日本循環器心身医学会抄録集　72nd　29　2015年
非心臓手術中に発症した薬剤溶出ステント留置後亜急性ステント血栓症の一例

深澤恭之朗, 圓谷隆治, 高橋潤, 須田彬, 西宮健介, 羽尾清貴, 松本泰治, 伊藤健太, 下川宏明

日本循環器学会東北地方会(Web)　161st　TOHOKU161,59 (WEB ONLY)　2015年
急性心筋梗塞発症率及び院内死亡率の年代別経年変化の検討―Miyagi AMI Registry Studyからの報告

崔元吉, 羽尾清貴, 高橋潤, 伊藤健太, 宮田敏, 西宮健介, 圓谷隆治, 松本泰治, 坂田泰彦, 下川宏明

日本心臓病学会学術集会(Web)　63rd　ROMBUNNO.P‐247 (WEB ONLY)　2015年
急性心筋梗塞の発症率と院内死亡率の近年における経年変化―MIYAGI‐AMI Registry Studyからの報告―

羽尾清貴, 高橋潤, 伊藤健太, 宮田敏, 崔元吉, 西宮健介, 圓谷隆治, 松本泰治, 坂田泰彦, 下川宏明

日本心臓病学会学術集会(Web)　63rd　ROMBUNNO.S2‐8 (WEB ONLY)　2015年
急性心筋梗塞後の左室リモデリングに対する低出力体外衝撃波治療の効果

加賀谷裕太, 伊藤健太, 高橋潤, 松本泰治, 圓谷隆治, 羽尾清貴, 西宮健介, 進藤智彦, 尾形剛, 黒澤亮, 江口久美子, 畠中和明, 宮田敏, 下川宏明

日本循環器学会東北地方会(Web)　161st　TOHOKU161,54 (WEB ONLY)　2015年
Fabry病に冠攣縮性狭心症を合併した一例

羽尾清貴, 西宮健介, 山本沙織, 圓谷隆治, 松本泰治, 杉村宏一郎, 高橋潤, 伊藤健太, 下川宏明

日本循環器学会東北地方会(Web)　161st　TOHOKU161,57 (WEB ONLY)　2015年
冠動脈攣縮における冠動脈イメージングの重要性

西宮健介, 松本泰治, 宇塚裕紀, 大山宗馬, 進藤智彦, 平野道基, 小鷹悠二, 羽尾清貴, 圓谷隆治, 高橋潤, 伊藤健太, 下川宏明

日本心臓病学会学術集会(Web)　63rd　ROMBUNNO.S1‐5 (WEB ONLY)　2015年
冠微小循環障害と血中セロトニンの関連の検討

小鷹悠二, 高橋潤, 須田彬, 小松真恭, 西宮健介, 羽尾清貴, 円谷隆治, 松本泰治, 伊藤健太, 下川宏明

脈管学(Web)　55　(supplement)　S137(J‐STAGE)　2015年

ISSN： 1880-8840
Impact of Additive Use of Olmesartan in Patients With Chronic Heart Failure: The Supplemental Benefit of an Angiotensin Receptor Blocker in Hypertensive Patients With Stable Heart Failure Using Olmesartan (SUPPORT) Trial

Yasuhiko Sakata, Nobuyuki Shiba, Jun Takahashi, Satoshi Miyata, Kotaro Nochioka, Masanobu Miura, Tsuyoshi Takada, Hiroaki Shimokawa

CIRCULATION　130　(23)　2116-2116　2014年12月

ISSN： 0009-7322

eISSN： 1524-4539
Enhanced Adventitial Vasa Vasorum Formation in Patients With Vasospastic Angina -Assessment With Optical Frequency Domain Imaging-

Kensuke Nishimiya, Yasuharu Matsumoto, Jun Takahashi, Takeshi Kato, Kazuma Oyama, Uzuka Hironori, Yuji Odaka, Taro Nihei, Kiyotaka Hao, Ryuji Tsuburaya, Kenta Ito, Hiroaki Shimokawa

CIRCULATION　130　2014年11月

ISSN： 0009-7322

eISSN： 1524-4539
Factors Influencing the Occurrence of Cardiopulmonary Arrest in the Great East Japan Earthquake Disaster

Kiyotaka Hao, Jun Takahashi, Tatsuo Aoki, Satoshi Miyata, Taro Nihei, Shunsuke Nishimiya, Ryuji Tsuburaya, Yasuharu Matsumoto, Kenta Ito, Yasuhiko Sakata, Hiroaki Shimokawa

CIRCULATION　130　2014年11月

ISSN： 0009-7322

eISSN： 1524-4539
Prognostic Impact of Rho-kinase Activity in Circulating Leukocytes of Patients with Vasospastic Angina

Taro Nihei, Jun Takahashi, Ryuji Tsuburaya, Kiyotaka Hao, Yuji Odaka, Kensuke Nishimiya, Yasuharu Matsumoto, Kenta Ito, Hiroaki Shimokawa

CIRCULATION　130　2014年11月

ISSN： 0009-7322

eISSN： 1524-4539
Sex Differences in Clinical Characteristics and Outcomes of Patients with Heart Failure with Preserved Ejection Fraction -A Report from the CHART-2 Study

Kanako Tsuji, Yasuhiko Sakata, Masanobu Miura, Satoshi Miyata, Kotaro Nochioka, Soichiro Tadaki, Ryoichi Ushigome, Takeshi Yamauchi, Kenjiro Sato, Takeo Onose, Run Abe, Jun Takahashi, Hiroaki Shimokawa

CIRCULATION　130　2014年11月

ISSN： 0009-7322

eISSN： 1524-4539
冠攣縮性狭心症の診断と治療に関するガイドライン(2013年改訂版) (視野が広がるミニ特集心臓病治療に欠かせないガイドライン : 2012~2013年改訂版ケアに生かす改訂ポイントはここ!(前編))

高橋潤, 下川宏明

Heart nursing　27　(10)　1090-1095　2014年10月
出版者・発行元：メディカ出版
ISSN： 0914-2819
The Chronic Heart Failure Analysis and Registry in the Tohoku District (CHART) Study

Yaushiko Sakata, Kotaro Nochioka, Masanobu Miura, Soichiro Tadaki, Ryoichi Ushigome, Takeshi Yamauchi, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　20　(10)　S137-S137　2014年10月

DOI： 10.1016/j.cardfail.2014.07.028 　

ISSN： 1071-9164

eISSN： 1532-8414
Prognostic Impacts of Aldosterone Antagonists in Patients with Heart Failure with Preserved Ejection Fraction-A Report from the CHART-2 Study

Masanobu Miura, Yasuhiko Sakata, Satoshi Miyata, Kotaro Nochioka, Tsuyoshi Takada, Soichiro Tadaki, Ryoichi Ushigome, Takeshi Yamauchi, Jun Takahashi, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　20　(10)　S170-S170　2014年10月

DOI： 10.1016/j.cardfail.2014.07.220 　

ISSN： 1071-9164

eISSN： 1532-8414
低出力体外衝撃波治療心血管疾患に対する新しい非侵襲性血管新生療法

伊藤健太, 高橋潤, 松本泰治, 圓谷隆治, 羽尾清貴, 西宮健介, 二瓶太郎, 下川宏明

脈管学　54　(Suppl.)　S149-S149　2014年10月
出版者・発行元： (一社)日本脈管学会
ISSN： 0387-1126
重度腎機能障害例における冠動脈インターベンション後の腎機能悪化に対する予防的血液透析の効果に関する検討

圓谷隆治, 高橋潤, 二瓶太郎, 西宮健介, 羽尾清貴, 白戸崇, 松本泰治, 伊藤健太, 下川宏明

日本心臓病学会学術集会抄録(CD-ROM)　62nd　ROMBUNNO.O-145　2014年9月2日
Optical Frequency Domain Imaging(OFDI)による冠動脈外膜Vasa Vasorumの生体内画像評価

西宮健介, 松本泰治, 宇塚裕紀, 進藤智彦, 長谷部雄飛, 二瓶太郎, 羽尾清貴, 圓谷隆治, 高橋潤, 伊藤健太, 下川宏明

日本心臓病学会学術集会抄録(CD-ROM)　62nd　ROMBUNNO.O-058　2014年9月2日
冠微小血管攣縮と血中セロトニンの関連の検討

小鷹悠二, 円谷隆治, 高橋潤, 二瓶太郎, 西宮健介, 羽尾清貴, 松本泰治, 伊藤健太, 廣渡祐史, 下川宏明

日本心臓病学会学術集会抄録(CD-ROM)　62nd　ROMBUNNO.O-271　2014年9月2日
冠動脈攣縮に関する画像研究の新知見

西宮健介, 松本泰治, 宇塚裕紀, 尾形剛, 小鷹悠二, 平野道基, 進藤智彦, 長谷部雄飛, 二瓶太郎, 羽尾清貴, 圓谷隆治, 高橋潤, 伊藤健太, 下川宏明

日本心臓病学会学術集会抄録(CD-ROM)　62nd　ROMBUNNO.S16-1　2014年9月2日
急性心筋梗塞患者における冠動脈インターベンション未施行例の特徴―宮城県心筋梗塞対策協議会からの報告―

羽尾清貴, 高橋潤, 伊藤健太, 宮田敏, 坂田泰彦, 二瓶太郎, 西宮健介, 圓谷隆治, 松本泰治, 安田聡, 下川宏明

日本心臓病学会学術集会抄録(CD-ROM)　62nd　ROMBUNNO.O-378　2014年9月2日
冠攣縮性狭心症の病態における冠動脈外膜Vasa Vasorumの関与―光干渉断層画像(OFDI)を用いた臨床的検討―

西宮健介, 松本泰治, 高橋潤, 宇塚裕紀, 小鷹悠二, 二瓶太郎, 羽尾清貴, 圓谷隆治, 伊藤健太, 下川宏明

日本心臓病学会学術集会抄録(CD-ROM)　62nd　ROMBUNNO.O-059　2014年9月2日
薬剤溶出性ステント留置後にステント離断をきたし冠動脈瘤を形成した若年川崎病後遺症の一例

二瓶太郎, 高橋潤, 小鷹悠二, 西宮健介, 羽尾清貴, 圓谷隆二, 松本泰治, 伊藤健太, 坂田泰彦, 下川宏明

日本心臓病学会学術集会抄録(CD-ROM)　62nd　ROMBUNNO.O-021　2014年9月2日
冠攣縮性狭心症の長期予後予測におけるRhoキナーゼ活性の有用性

二瓶太郎, 高橋潤, 小鷹悠二, 西宮健介, 羽尾清貴, 圓谷隆二, 松本泰治, 伊藤健太, 坂田泰彦, 下川宏明

日本心臓病学会学術集会抄録(CD-ROM)　62nd　ROMBUNNO.O-269　2014年9月2日
東日本大震災後に認められた心肺停止症例の増加に関係する因子の検討

羽尾清貴, 高橋潤, 青木竜男, 宮田敏, 二瓶太郎, 西宮健介, 圓谷隆治, 松本泰治, 伊藤健太, 坂田泰彦, 下川宏明

日本心臓病学会学術集会抄録(CD-ROM)　62nd　ROMBUNNO.O-137-137　2014年9月2日
出版者・発行元： (一社)日本心臓病学会
Predictors for the transition to de novo heart failure in stage B asymptomatic patients - A report from the CHART-2 Study -

T. Takada, Y. Sakata, S. Miyata, J. Takahashi, K. Nochioka, M. Miura, S. Tadaki, R. Ushigome, T. Yamauchi, H. Shimokawa

EUROPEAN HEART JOURNAL　35　1029-1030　2014年9月

ISSN： 0195-668X

eISSN： 1522-9645
川崎病性冠動脈瘤患者の遠隔期予後

木村正人, 鈴木大, 小野頼母, 川合英一郎, 大軒健彦, 高橋怜, 呉繁夫, 高橋潤, 川本俊輔

日本小児科学会雑誌　118　(9)　1415-1415　2014年9月
出版者・発行元： (公社)日本小児科学会
ISSN： 0001-6543
Comparison of the prognostic impact of diabetes mellitus between ischemic and non-ischemic heart failure -a report from the chart-2 study-

M. Miura, Y. Sakata, S. Miyata, K. Nochioka, T. Takada, R. Tadaki, R. Ushigome, T. Yamauchi, J. Takahashi, H. Shimokawa

EUROPEAN HEART JOURNAL　35　335-335　2014年9月

ISSN： 0195-668X

eISSN： 1522-9645
Possible involvement of adventitial sympathetic nerve in the coronary hyperconstricting responses after drug-eluting stent implantation in pigs in vivo

H. Uzuka, Y. Matsumoto, K. Nishimiya, T. Shindo, K. Hanawa, Y. Hasebe, R. Tsuburaya, J. Takahashi, H. Shimokawa

EUROPEAN HEART JOURNAL　35　806-806　2014年9月

ISSN： 0195-668X

eISSN： 1522-9645
Decreased cerebral blood flow and BDNF levels are associated with depression and memory impairment in patients with heart failure -Brain Assessment and Investigation in Heart Failure Trial (B-HeFT)-

H. Suzuki, Y. Matsumoto, H. Ota, K. Sugimura, J. Takahashi, K. Ito, Y. Fukumoto, R. Kawashima, Y. Taki, H. Shimokawa

EUROPEAN HEART JOURNAL　35　13-13　2014年9月

ISSN： 0195-668X

eISSN： 1522-9645
Usefulness of optical frequency domain imaging for vasa vasorum visualization in stented coronary arteries in pigs and humans

K. Nishimiya, Y. Matsumoto, H. Uzuka, T. Shindo, Y. Hasebe, K. Hao, R. Tsuburaya, J. Takahashi, K. Ito, H. Shimokawa

EUROPEAN HEART JOURNAL　35　1144-1144　2014年9月

ISSN： 0195-668X

eISSN： 1522-9645
Enhanced adventitial vasa vasorum formation in patients with vasospastic angina - Assessment with optical frequency domain imaging-

K. Nishimiya, Y. Matsumoto, J. Takahashi, T. Kato, Y. Odaka, T. Nihei, K. Hao, R. Tsuburaya, K. Ito, H. Shimokawa

EUROPEAN HEART JOURNAL　35　342-342　2014年9月

ISSN： 0195-668X

eISSN： 1522-9645
Prognostic impact of rho-kinase activity in circulating leukocytes of patients with vasospastic sangina

T. Nihei, J. Takahashi, R. Tsuburaya, K. Hao, Y. Odaka, K. Nishimiya, Y. Matsumoto, K. Ito, H. Shimokawa

EUROPEAN HEART JOURNAL　35　1198-1198　2014年9月

ISSN： 0195-668X

eISSN： 1522-9645
Recent Trends in Clinical Characteristics, Management and Prognosis of Patients with Dilated Cardiomyopathy in Japan-A Report from the CHART Studies

Ryoichi Ushigome, Yasuhiko Sakata, Kotaro Nochioka, Satoshi Miyata, Masanobu Miura, Soichiro Tadaki, Takeshi Yamauchi, Jun Takahashi, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　20　(8)　S45-S45　2014年8月

DOI： 10.1016/j.cardfail.2014.06.126 　

ISSN： 1071-9164

eISSN： 1532-8414
Morbidity Of Chronic Obstructive Pulmonary Disease And Poor Lung Function May Promote The Occurrence Of Acute Coronary Syndrome In Patients With Organic Coronary Stenosis

T. Komaru, H. Kato, C. Takahashi, A. Tashiro, K. -Y. Saji, M. Miura

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　189　2014年

ISSN： 1073-449X

eISSN： 1535-4970
周術期リハビリテーション介入が必要であったTAVIの一例~術前の『Frailty』評価の意義~

竹内雅史, 松本泰治, 川本俊輔, 熊谷紀一郎, 杉村宏一郎, 三浦正暢, 高橋潤, 柿花隆昭, 矢口春木, 和地泰彦, 仲冨千瑞, 佐藤房郎, 吾妻俊弘, 森信芳, 伊藤修, 伊藤健太, 上月正博, 齋木佳克, 下川宏明

日本循環器学会東北地方会(Web)　159th　2014年
胃癌を合併した症候性重症大動脈弁狭窄症に対する経カテーテル大動脈弁留置術の一例

松本泰治, 高橋潤, 杉村宏一郎, 三浦正暢, 山本沙織, 川本俊輔, 熊谷紀一郎, 吾妻俊弘, 山口辰寛, 篠崎毅, 齋木佳克, 下川宏明

日本循環器学会東北地方会(Web)　159th　2014年
経カテーテル大動脈弁留置術後に完全房室ブロックを呈した一症例

佐藤遥, 松本泰治, 杉村宏一郎, 矢尾板信裕, 山本沙織, 建部俊介, 三浦正暢, 青木竜男, 後岡広太郎, 高橋潤, 熊谷紀一郎, 川本俊輔, 吾妻俊弘, 小山二郎, 井上寛一, 齋木佳克, 下川宏明

日本循環器学会東北地方会(Web)　159th　TOHOKU159,75 (WEB ONLY)　2014年
冠攣縮性狭心症の鑑別が有用であった冠動脈インターベンションによる完全血行再建後の1例

羽尾清貴, 高橋潤, 二瓶太郎, 西宮健介, 圓谷隆治, 松本泰治, 伊藤健太, 坂田泰彦, 下川宏明

日本循環器学会東北地方会(Web)　158th　TOHOKU158,62 (WEB ONLY)　2014年
冠動脈ステント破損が冠動脈瘤形成に関与した若年川崎病後遺症の一例

二瓶太郎, 高橋潤, 圓谷隆治, 羽尾清貴, 西宮健介, 小鷹悠二, 松本泰治, 伊藤健太, 坂田泰彦, 下川宏明

日本循環器学会東北地方会(Web)　158th　TOHOKU158,63 (WEB ONLY)　2014年
薬剤負荷心筋血流シンチにて陽性所見を呈した冠攣縮性狭心症の一例

山内悠平, 圓谷隆治, 二瓶太郎, 西宮健介, 羽尾清貴, 松本泰治, 高橋潤, 伊藤健太, 坂田泰彦, 下川宏明

日本循環器学会東北地方会(Web)　158th　TOHOKU158,64 (WEB ONLY)　2014年
ステロイド補充開始後に冠攣縮性狭心症発作を認めたACTH単独欠損症の一例

小松真恭, 西宮健介, 高橋潤, 圓谷隆治, 二瓶太郎, 羽尾清貴, 松本泰治, 伊藤健太, 坂田泰彦, 下川宏明

日本循環器学会東北地方会(Web)　159th　TOHOKU159,48 (WEB ONLY)　2014年
低出力体外衝撃波治療:心血管疾患に対する新しい非侵襲性血管新生療法

伊藤健太, 高橋潤, 松本泰治, 圓谷隆治, 羽尾清貴, 西宮健介, 二瓶太郎, 下川宏明

脈管学(Web)　54　(Supplement)　S149(J-STAGE)　2014年

ISSN： 1880-8840
冠攣縮性狭心症を合併した肥大型心筋症の一例

金沙織, 羽尾清貴, 大山宗馬, 高橋潤, 西宮健介, 圓谷隆治, 松本泰治, 伊藤健太, 坂田泰彦, 下川宏明

日本循環器学会東北地方会(Web)　159th　TOHOKU159,49 (WEB ONLY)　2014年
全身性エリテマトーテスによる冠動脈拡張により生じた急性冠症候群の一例

中嶋優太, 圓谷隆治, 西宮健介, 羽尾清貴, 松本泰治, 高橋潤, 伊藤健太, 下川宏明

日本循環器学会東北地方会(Web)　159th　TOHOKU159,56 (WEB ONLY)　2014年
Important Role of Adventitial Vasa Vasorum in the Pathogensis of Coronary Hyperconstricting Responses After Drug-Eluting Stent Implantation in Pigs in Vivo

Kensuke Nishimiya, Yasuharu Matsumoto, Jun Takahashi, Tomohiko Shindo, Kenichiro Hanawa, Yuhi Hasebe, Ryuji Tsuburaya, Takashi Shiroto, Kenta Ito, Hatsue Ishibashi-Ueda, Satoshi Yasuda, Hiroaki Shimokawa

CIRCULATION　128　(22)　2013年11月

ISSN： 0009-7322

eISSN： 1524-4539
Subclinical Microalbuminuria is Associated With Poor Prognosis in Patients With Chronic Heart Failure With Preserved Renal Function-A Report From the CHART-2 Study

Masanobu Miura, Yasuhiko Sakata, Satoshi Miyata, Kotaro Nochioka, Tsuyoshi Takada, Soichiro Tadaki, Jun Takahashi, Hiroaki Shimokawa

CIRCULATION　128　(22)　2013年11月

ISSN： 0009-7322

eISSN： 1524-4539
Statin Use is Associated With Reduced Mortality in Patients With Heart Failure With Preserved Ejection Fraction -A Report From the CHART-2 Study

Kotaro Nochioka, Yasuhiko Sakata, Satoshi Miyata, Jun Takahashi, Masanobu Miura, Tsuyoshi Takada, Soichiro Tadaki, Ryouichi Ushigome, Hiroaki Shimokawa

CIRCULATION　128　(22)　2013年11月

ISSN： 0009-7322

eISSN： 1524-4539
Prognostic Impact of Coronary Revascularization Therapy in Patients With Ischemic Heart Failure

Jun Takahashi, Yasuhiko Sakata, Kotaro Nochioka, Masanobu Miura, Tsuyoshi Takada, Satoshi Miyata, Hiroaki Shimokawa

CIRCULATION　128　(22)　2013年11月

ISSN： 0009-7322

eISSN： 1524-4539
Emergency Care of Acute Myocardial Infarction during the Great East Japan Earthquake Disaster-Report from the Miyagi AMI Registry Study-

Kiyotaka Hao, Jun Takahashi, Satoshi Miyata, Yasuharu Sakata, Ryuji Tsuburaya, Takashi Shiroto, Yasuharu Matsumoto, Kenta Ito, Satoshi Yasuda, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　19　(10)　S154-S154　2013年10月

DOI： 10.1016/j.cardfail.2013.08.239 　

ISSN： 1071-9164

eISSN： 1532-8414
Prognostic Impact of Urine Protein in Diabetic Patients with Ischemic Heart Failure-A Report from the CHART-2 Study-

Masanobu Miura, Yasuhiko Sakata, Satoshi Miyata, Kotaro Nochioka, Tsuyoshi Takada, Soichiro Tadaki, Jun Takahashi, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　19　(10)　S136-S136　2013年10月

DOI： 10.1016/j.cardfail.2013.08.182 　

ISSN： 1071-9164

eISSN： 1532-8414
Circulating DPP4 Activity Predicts Systolic Left-ventricular Dysfunction in Heart Failure Patients.

Kotaro Nochioka, Yasuhiko Sakata, Satoshi Miyata, Jun Takahashi, Masanobu Miura, Tsuyoshi Takada, Soichiro Tadaki, Ryouichi Ushigome, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　19　(10)　S132-S132　2013年10月

DOI： 10.1016/j.cardfail.2013.08.146 　

ISSN： 1071-9164

eISSN： 1532-8414
Different Impact of Anemia in Chronic Heart Failure with Preserved vs. Reduced Ejection Fraction -A Report from the CHART-2 Study-

Tsuyoshi Takada, Yasuhiko Sakata, Satoshi Miyata, Jun Takahashi, Kotaro Nochioka, Masanobu Miura, Souichiro Tadaki, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　19　(10)　S134-S134　2013年10月

DOI： 10.1016/j.cardfail.2013.08.156 　

ISSN： 1071-9164

eISSN： 1532-8414
Interactions between the Heart and the Brain in Heart Failure Patients Assessed by MRI -Interim Results from the B-HeFT Study-

Hideaki Suzuki, Yasuharu Matsumoto, Jun Takahashi, Ryuji Tsuburaya, Koichiro Sugimura, Kenta Ito, Yoshihiro Fukumoto, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　19　(10)　S132-S132　2013年10月

ISSN： 1071-9164

eISSN： 1532-8414
Longitudinal Study of Post-Traumatic Stress Disorder after the Great East Japan Earthquake Disaster in Cardiovascular Disease Patients - The CHART-2 Study

Kotaro Nochioka, Yasuhiko Sakata, Satoshi Miyata, Jun Takahashi, Masanobu Miura, Tsuyoshi Takada, Soichiro Tadaki, Ryouichi Ushigome, Tsuyoshi Yamauchi, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　19　(10)　S105-S105　2013年10月

DOI： 10.1016/j.cardfail.2013.08.012 　

ISSN： 1071-9164

eISSN： 1532-8414
Factors influencing transition to symptomatic heart failure in Stage-B asymptomatic patients -A report from the CHART-2 study

T. Takada, Y. Sakata, S. Miyata, J. Takahashi, K. Nochioka, M. Miura, S. Tadaki, H. Shimokawa

EUROPEAN HEART JOURNAL　34　778-778　2013年8月

ISSN： 0195-668X

eISSN： 1522-9645
Different impact of elevated heart rate on cardiovascular events between heart failure with reduced ejection fraction and preserved ejection fraction - a report from the CHART-2 study

T. Takada, Y. Sakata, S. Miyata, J. Takahashi, K. Nochioka, M. Miura, S. Tadaki, H. Shimokawa

EUROPEAN HEART JOURNAL　34　349-349　2013年8月

ISSN： 0195-668X

eISSN： 1522-9645
Essential role of polymer-coating in the pathogenesis of coronary hyperconstricting responses after drug-eluting stent implantation in pigs in vivo

K. Nishimiya, Y. Matsumoto, J. Takahashi, T. Shindo, K. Hanawa, Y. Hasebe, R. Tsuburaya, T. Shiroto, K. Ito, H. Shimokawa

EUROPEAN HEART JOURNAL　34　223-223　2013年8月

ISSN： 0195-668X

eISSN： 1522-9645
Circadian variation of rho-kinase activity associated with enhanced coronary reactivity in patients with vasospastic angina

T. Nihei, J. Takahashi, Y. Kikuchi, R. Tsuburaya, T. Shiroto, Y. Ito, Y. Matsumoto, M. Nakayama, K. Ito, H. Shimokawa

EUROPEAN HEART JOURNAL　34　724-724　2013年8月

ISSN： 0195-668X

eISSN： 1522-9645
Mortality risk stratification according to combined heart rate and systolic blood pressure in patients with chronic heart failure -a report from the chart-2 study

M. Miura, Y. Sakata, S. Miyata, K. Nochioka, T. Takada, S. Tadaki, J. Takahashi, N. Shiba, H. Shimokawa

EUROPEAN HEART JOURNAL　34　295-295　2013年8月

ISSN： 0195-668X

eISSN： 1522-9645
Prognostic impact of subclinical microalbuminuria in patients with chronic heart failure

M. Miura, Y. Sakata, S. Miyata, K. Nochioka, T. Takada, S. Tadaki, J. Takahashi, N. Shiba, H. Shimokawa

EUROPEAN HEART JOURNAL　34　288-288　2013年8月

ISSN： 0195-668X

eISSN： 1522-9645
Impact of adventitial vasa vasorum in the pathogenesis of coronary vasomotor dysfunction after drug-eluting stents implantation in pigs in vivo

K. Nishimiya, Y. Matsumoto, J. Takahashi, R. Tsuburaya, T. Shiroto, K. Ito, H. Ishibashi-Ueda, S. Yasuda, H. Shimokawa

EUROPEAN HEART JOURNAL　34　319-320　2013年8月

ISSN： 0195-668X

eISSN： 1522-9645
急性冠症候群の疫学 (特集急性冠症候群の臨床)

下川宏明, 高橋潤, 羽尾清貴

日本医師会雑誌　141　(12)　2626-2630　2013年3月
出版者・発行元：日本医師会
ISSN： 0021-4493
心筋梗塞の長期予後と再発防止 (特集虚血性心疾患)

高橋潤, 下川宏明

診断と治療　101　(1)　143-148　2013年1月
出版者・発行元：診断と治療社
ISSN： 0370-999X
拡張型心筋症急性増悪に対しBridge to decisionを行った2症例の経験

片平晋太郎, 秋山正年, 本吉直孝, 川本俊輔, 齋木佳克, 三浦正暢, 後岡広太郎, 三浦裕, 杉村宏一郎, 福本義弘, 高橋潤, 福田浩二, 下川宏明

日本循環器学会東北地方会(Web)　156th　2013年
腸管虚血を併発した劇症型心筋炎2症例

片平晋太郎, 秋山正年, 細山勝寛, 河津聡, 熊谷紀一郎, 本吉直孝, 川本俊輔, 齋木佳克, 三浦正暢, 後岡広太郎, 杉村宏一郎, 高橋潤, 福田浩二, 下川宏明

日本循環器学会東北地方会(Web)　157th　2013年
サイクロフィリンAによる心血管病促進機構とバイオマーカーとしての可能性

佐藤公雄, 福本義弘, 杉村宏一郎, 後岡広太郎, 青木竜男, 建部俊介, 山本沙織, 高木祐介, 圓谷隆治, 伊藤愛剛, 中山雅晴, 武田守彦, 高橋潤, 伊藤健太, 安田聡, 下川宏明

日本NO学会学術集会プログラム抄録集　13th　2013年
低体温療法中に心機能低下をきたし,経皮的人工心肺による管理を要した一例

有竹秀美, 鈴木秀明, 大村拓, 工藤大介, 入野田崇, 円谷隆治, 白戸崇, 松本泰治, 高橋潤, 伊藤健太, 加賀谷豊, 久志本成樹, 下川宏明

日本循環器学会東北地方会(Web)　157th　TOHOKU157,79 (WEB ONLY)　2013年
Beneficial Effects of a Single Prophylactic Hemodialysis on Renal Function Worsening after Percutaneous Coronary Intervention in Patients with Severe CKD

Ryuji Tsuburaya, Jun Takahashi, Yusuke Takagi, Yoshitaka Ito, Yasuharu Matsumoto, Kenta Ito, Masaharu Nakayama, Hiroaki Shimokawa

CIRCULATION　126　(21)　2012年11月

ISSN： 0009-7322

eISSN： 1524-4539
Enhanced Rho-kinase Activity in Circulating Neutrophils of Patients with Vasospastic Angina after the Great East Japan Earthquake

Taro Nihei, Jun Takahashi, Yoku Kikuchi, Kiyotaka Hao, Yusuke Takagi, Ryuji Tsuburaya, Takashi Shiroto, Yoshitaka Ito, Yasuharu Matsumoto, Masaharu Nakayama, Kenta Ito, Satoshi Yasuda, Hiroaki Shimokawa

CIRCULATION　126　(21)　2012年11月

ISSN： 0009-7322

eISSN： 1524-4539
Risk Stratification with Control Status of Systolic Blood Pressure and Heart Rate in Patients with Chronic Heart Failure An Interim Analysis of the CHART-2 Study

Masanobu Miura, Yasuhiko Sakata, Kotaro Nochioka, Tsuyoshi Takada, Satoshi Miyata, Jun Takahashi, Nobuyuki Shiba, Hiroaki Shimokawa

CIRCULATION　126　(21)　2012年11月

ISSN： 0009-7322

eISSN： 1524-4539
Increased Heart Rate as a Significant Prognostic Factor in Patients with Heart Failure with Preserved Ejection Fraction -A Report from the CHART-2 Study-

Tsuyoshi Takada, Yasuhiko Sakata, Satoshi Miyata, Jun Takahashi, Kotaro Nochioka, Masanobu Miura, Hiroaki Shimokawa

CIRCULATION　126　(21)　2012年11月

ISSN： 0009-7322

eISSN： 1524-4539
Factors Influencing the Development of De Novo Heart Failure in Stage-B Asymptomatic Patients-A Report From the CHART-2 Study-

Tsuyoshi Takada, Yasuhiko Sakata, Satoshi Miyata, Jun Takahashi, Kotaro Nochioka, Masanobu Miura, Hiroaki Shimokawa

CIRCULATION　126　(21)　2012年11月

ISSN： 0009-7322

eISSN： 1524-4539
Prognostic Impact of Long-acting Nitrate Therapy in Patients with Vasospastic Angina -A Report from the Japanese Coronary Spasm Association-

Yusuke Takagi, Jun Takahashi, Satoshi Yasuda, Ryusuke Tsunoda, Yasuhiro Ogata, Atsushi Seki, Tetsuya Sumiyoshi, Motoyuki Matsui, Toshikazu Goto, Yasuhiko Tanabe, Shozo Sueda, Toshiaki Sato, Satoshi Ogawa, Norifumi Kubo, Shin-ichi Momomura, Hisao Ogawa, Hiroaki Shimokawa

CIRCULATION　126　(21)　2012年11月

ISSN： 0009-7322

eISSN： 1524-4539
Factors Influencing the Higher In-Hospital Mortality of Female Patients with Acute Myocardial Infarction

Yoshitaka Ito, Jun Takahashi, Kiyotaka Hao, Yusuke Takagi, Ryuji Tsuburaya, Takashi Shiroto, Yasuharu Matsumoto, Masaharu Nakayama, Kenta Ito, Satoshi Yasuda, Hiroaki Shimokawa

CIRCULATION　126　(21)　2012年11月

ISSN： 0009-7322

eISSN： 1524-4539
Increased Incidence of Heart Failure in the East Japan Earthquake

Tatsuo Aoki, Yoshihiro Fukumoto, Satoshi Yasuda, Yasuhiko Sakata, Kenta Ito, Jun Takahashi, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　18　(10)　S123-S124　2012年10月

ISSN： 1071-9164
Prevalence of Post-Traumatic Stress Disorder after the Great East Japan Earthquake in Patients with Cardiovascular Diseases -The CHART-2 Study-

Kotaro Nochioka, Yasuhiko Sakata, Jun Takahashi, Masanobu Miura, Tsuyoshi Takada, Yoshihiro Fukumoto, Satoshi Miyata, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　18　(10)　S154-S154　2012年10月

DOI： 10.1016/j.cardfail.2012.08.154 　

ISSN： 1071-9164
Influence of Coexisting Heart Failure on Non-performance of Primary Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction

Kiyotaka Hao, Jun Takahashi, Ryuji Tsuburaya, Takashi Shiroto, Yoshitaka Ito, Yasuharu Matsumoto, Masaharu Nakayama, Kenta Ito, Satoshi Yasuda, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　18　(10)　S163-S163　2012年10月

ISSN： 1071-9164
Stratification of the Mortality Risk According to Heart Rate and Systolic Blood Pressure in Heart Failure Patients

Masanobu Miura, Yasuhiko Sakata, Kotaro Nochioka, Tsuyoshi Takada, Satoshi Miyata, Jun Takahashi, Nobuyuki Shiba, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　18　(10)　S165-S166　2012年10月

DOI： 10.1016/j.cardfail.2012.08.218 　

ISSN： 1071-9164
No Increase in the Incidence of Takotsubo Cardiomyopathy after the Great East Japan Earthquake

Kota Suzuki, Yasuharu Matsumoto, Jun Takahashi, Ryuji Tsuburaya, Yoshitaka Ito, Kouichirou Sugimura, Masaharu Nakayama, Kenta Ito, Yoshihiro Fukumoto, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　18　(10)　S163-S163　2012年10月

ISSN： 1071-9164
Etiology and Predictive Factors of De Novo Heart Failure in Stage-B Asymptomatic Patients -Insight front the CHART-2 Study-

Tsuyoshi Takada, Yasuhiko Sakata, Satoshi Miyata, Jun Takahashi, Kotaro Nochioka, Masanobu Miura, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　18　(10)　S149-S149　2012年10月

DOI： 10.1016/j.cardfail.2012.08.130 　

ISSN： 1071-9164
Cessation of Spironolactone Worsens Long-term Prognosis of Heart Failure Patients

Masaharu Nakayama, Jun Takahashi, Kenta Ito, Yasuharu Matsumoto, Yoshitaka Ito, Ryuji Tsuburaya, Takashi Shiroto, Yusuke Takagi, Kiyotaka Hao, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　18　(10)　S158-S158　2012年10月

ISSN： 1071-9164
Acute Heart Failure Caused by Biventricular Involvement of Takotsubo Cardiomyopathy

Ryuji Tsuburaya, Jun Takahashi, Yoshitaka Ito, Yusuke Takagi, Yasuharu Matsumoto, Masaharu Nakayama, Kenta Ito, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　18　(10)　S177-S177　2012年10月

ISSN： 1071-9164
Post-Traumatic Stress Disorder after the Fukushima Daiichi Nuclear Plant Disaster in Patients with Cardiovascular Diseases -The CHART-2 Study-

Kotaro Nochioka, Yasuhiko Sakata, Satoshi Miyata, Masanobu Miura, Tsuyoshi Takada, Jun Takahashi, Yoshihiro Fukumoto, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　18　(10)　S150-S150　2012年10月

DOI： 10.1016/j.cardfail.2012.08.135 　

ISSN： 1071-9164
Etiology of Hypertensive Heart Failure: Insight from the CHART-2 Study

Yasuhiko Sakata, Kotaro Nochioka, Masanobu Miura, Tsuyoshi Takada, Satoshi Miyata, Jun Takahashi, Yoshihiro Fukumoto, Nobuyuki Shiba, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　18　(10)　S128-S128　2012年10月

DOI： 10.1016/j.cardfail.2012.08.041 　

ISSN： 1071-9164
Clinical Presentations of Heart Failure in the Elderly: Insight from the CHART-2 Study

Yasuhiko Sakata, Kotaro Nochioka, Masanobu Miura, Tsuyoshi Takada, Satoshi Miyata, Jun Takahashi, Yoshihiro Fukumoto, Nobuyuki Shiba, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　18　(10)　S126-S126　2012年10月

DOI： 10.1016/j.cardfail.2012.08.027 　

ISSN： 1071-9164
Prognostic Impact of Increased Heart Rate on Heart Failure with Preserved Ejection Fraction

Tsuyoshi Takada, Yasuhiko Sakata, Satoshi Miyata, Jun Takahashi, Kotaro Nochioka, Masanobu Miura, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　18　(10)　S147-S147　2012年10月

DOI： 10.1016/j.cardfail.2012.08.121 　

ISSN： 1071-9164
Development of clinical risk score for predicting cardiac events in patients with vasospastic angina - a report from the multicenter registry study by the japanese coronary spasm association-

Y. Takagi, J. Takahashi, S. Yasuda, Y. Ogata, T. Sumiyoshi, T. Goto, Y. Tanabe, S. Sueda, H. Ogawa, H. Shimokawa

EUROPEAN HEART JOURNAL　33　959-960　2012年8月

ISSN： 0195-668X
New generation biolimus A9-eluting stent suppresses coronary hyperconstricting responses and inflammation through rho-kinase pathway inhibition in pigs -comparison with a Sirolimus-Eluting Stent

K. Nishimiya, Y. Matsumoto, J. Takahashi, R. Tsuburaya, Y. Ito, K. Ito, H. Ishibashi-Ueda, S. Yasuda, H. Shimokawa

EUROPEAN HEART JOURNAL　33　175-176　2012年8月

ISSN： 0195-668X
Prognostic impact of blood urea nitrogen increase during admission in patients with acute heart failure syndrome

M. Miura, N. Shiba, J. Takahashi, K. Nochioka, T. Takada, T. Hiramoto, K. Inoue, K. Tamaki, H. Shimokawa

EUROPEAN HEART JOURNAL　33　486-486　2012年8月

ISSN： 0195-668X
Heart rate control is important even in heart failure patients -an interim analysis of the CHART-2 study

M. Miura, N. Shiba, J. Takahashi, K. Nochioka, T. Takada, H. Shimokawa

EUROPEAN HEART JOURNAL　33　938-938　2012年8月

ISSN： 0195-668X
Lerische症候群を伴った虚血性心筋症に対する左室形成術の1例

吉岡一朗, 川本俊輔, 高橋潤, 下川宏明, 齋木佳克

日本循環器学会東北地方会(Web)　154th　2012年
新規酸化ストレスマーカーのサイクロフィリンAの冠動脈疾患診断における有用性

佐藤公雄, 福本義弘, 杉村宏一郎, 三浦裕, 後岡広太郎, 青木竜男, 建部俊介, 山本沙織, 高木祐介, 圓谷隆治, 伊藤愛剛, 中山雅晴, 高橋潤, 伊藤健太, 下川宏明

日本酸化ストレス学会学術集会プログラム・抄録集　65th　2012年
長時間作用型Ca拮抗薬ニフェジピンによる薬剤溶出性ステント植え込み後の血管保護効果 Rhoキナーゼ経路の関与 (血管)

圓谷隆治, 安田聡, 白戸崇, 相澤健太郎, 伊藤愛剛, 松本泰治, 高橋潤, 伊藤健太, 下川宏明

血管　35　(1)　45-45　2012年
心臓カテーテル検査後にアナフィラクトイド紫斑病を急性発症した1例

前田恵, 高橋潤, 伊藤愛剛, 円谷隆治, 松本泰治, 武田守彦, 中山雅晴, 伊藤健太, 安田聡, 下川宏明

心臓　44　(9)　1173-1179　2012年
出版者・発行元： (公財)日本心臓財団
DOI： 10.11281/shinzo.44.1173 　

ISSN： 0586-4488

eISSN： 2186-3016
Usefulness of Rho-Kinase Activity in Circulating Neutrophils for Disease Activity Assessment of Vasospastic Angina

Yoku Kikuchi, Kentaro Aizawa, Satoshi Yasuda, Ryuji Tsuburaya, Yoshitaka Ito, Morihiko Takeda, Masaharu Nakayama, Kenta Ito, Jun Takahashi, Hiroaki Shimokawa

CIRCULATION　124　(21)　2011年11月

ISSN： 0009-7322
Continuous Renal Replacement Therapy for the Treatment of Acute Decompensated Heart Failure and Cardio-Renal Syndrome

Jun Takahashi, Satoshi Yasuda, Nobuyuki Shiba, Hiroaki Shimokawa

CIRCULATION　124　(21)　2011年11月

ISSN： 0009-7322
Involvement of Rho-Kinase Activation in the Pathogenesis of Coronary Hyperconstricting Responses Induced by Drug-Eluting Stents in Patients with Coronary Artery Disease

Kentaro Aizawa, Satoshi Yasuda, Jun Takahashi, Toru Takii, Yoku Kikuchi, Ryuji Tsuburaya, Yoshitaka Ito, Kenta Ito, Masaharu Nakayama, Morihiko Takeda, Hiroaki Shimokawa

CIRCULATION　124　(21)　2011年11月

ISSN： 0009-7322
Changes in Prevalence and Risk Factors of Acute Myocardial Infarction in the Rural and Urban District in Japan -Report from MIYAGI-AMI Registry Study

Kiyotaka Hao, Satoshi Yasuda, Toru Takii, Yoshitaka Ito, Akiko Kawana, Jun Takahashi, Morihiko Takeda, Kenta Ito, Hiroaki Shimokawa

CIRCULATION　124　(21)　2011年11月

ISSN： 0009-7322
Rural and Urban Difference in the Incidence and In-Hospital Mortality of Acute Myocardial Infarction -Report from the MIYAGI-AMI Registry Study-

Yoshitaka Ito, Satoshi Yasuda, Toru Takii, Kiyotaka Hao, Jun Takahashi, Kenta Ito, Nobuyuki Shiba, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　17　(9)　S157-S158　2011年9月

ISSN： 1071-9164
Increased Incidence of Heart Failure in the Tohoku Earthquake Initial Report from the Tohoku University Hospital

Jun Takahashi, Satoshi Yasuda, Masaharu Nakayama, Yoshitaka Ito, Kenta Ito, Koji Fukuda, Yoshihiro Fukumoto, Nobuyuki Shiba, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　17　(9)　S169-S169　2011年9月

ISSN： 1071-9164
Rho-kinase activity in circulating neutrophils of patients with vasospastic angina - non-invasive method for diagnosis and disease activity assessment

Y. Kikuchi, K. Aizawa, S. Yasuda, R. Tsuburaya, Y. Ito, M. Takeda, M. Nakayama, K. Ito, J. Takahashi, H. Shimokawa

EUROPEAN HEART JOURNAL　32　255-256　2011年8月

ISSN： 0195-668X
Involvement of rho-kinase activation in the pathogenesis of coronary hyperconstricting responses by drug-eluting stents in patients with coronary artery disease

K. Aizawa, S. Yasuda, J. Takahashi, T. Takii, Y. Kikuchi, Y. Ito, K. Ito, M. Nakayama, M. Takeda, H. Shimokawa

EUROPEAN HEART JOURNAL　32　239-239　2011年8月

ISSN： 0195-668X
3T MRIにおける頸動脈複雑プラーク(AHA type VI)と冠動脈病変との関連についての検討

大田英揮, 及川美奈子, 武田守彦, 安田聡, 高橋潤, 伊藤愛剛, 福本義弘, 高瀬圭, 下川宏明, 高橋昭喜

日独医報　55　(3-4)　315-315　2011年2月
出版者・発行元：バイエル薬品(株)
ISSN： 0912-0351
急性心筋梗塞後にblow-out型心破裂を合併し救命後,慢性期左室仮性瘤形成のため再手術を要した症例

大橋潤子, 松本泰治, 高橋潤, 武田守彦, 伊藤健太, 中山雅晴, 伊藤愛剛, 圓谷隆治, 高木祐介, 二瓶太郎, 安田聡, 北向修, 尾形公彦, 川本俊輔, 齋木佳克, 下川宏明

日本循環器学会東北地方会(Web)　153rd　2011年
慢性透析患者の冠疾患に対する外科治療成績改善のための臨床的解析

川本俊輔, 増田信也, 早津幸弘, 高橋潤, 下川宏明, 齋木佳克

日本循環器学会東北地方会(Web)　153rd　2011年
MIYAGI-AMI Registry報告宮城県内の急性心筋梗塞患者院内死亡率に関する地域差・性差 (日本内科学会雑誌)

伊藤愛剛, 川名暁子, 安田聡, 瀧井暢, 高橋潤, 伊藤健太, 福本義弘, 柴信行, 下川宏明

日本内科学会雑誌　100　(Suppl.)　216-216　2011年
シロリムス溶出性ステント留置3年後に超遅発性ステント血栓症を発症し、さらにその2年半後に院外心停止をきたした1例

武田守彦, 高橋潤, 円谷隆治, 伊藤愛剛, 高木祐介, 中山雅晴, 伊藤健太, 安田聡, 下川宏明

心臓　43　(Suppl.2)　164-164　2011年
出版者・発行元： (公財)日本心臓財団
DOI： 10.11281/shinzo.43.S2_164 　

ISSN： 0586-4488

eISSN： 2186-3016
Enhanced Rho-kinase Activity in Circulating Neutrophils in Patients with Vasospastic Angina-Possible Usefulness for Diagnosis and Disease Activity Assessment-

Yoku Kikuchi, Kentaro Aizawa, Satoshi Yasuda, Ryuji Tsuburaya, Yoshitaka Ito, Masaharu Nakayama, Morihiko Takeda, Kenta Ito, Jun Takahashi, Hiroaki Shimokawa

CIRCULATION　122　(21)　2010年11月

ISSN： 0009-7322
Usefulness of Dual Induction Tests for Coronary Vasospasm and Ventricular Fibrillation for Individualized Treatment of Survivors from Out-of-Hospital Cardiac Arrest without Structural Heart Disease

Yusuke Takagi, Satoshi Yasuda, Jun Takahashi, Ryuji Tsuburaya, Yoshitaka Ito, Morihiko Takeda, Kenta Ito, Yuji Wakayama, Koji Fukuda, Masafumi Sugi, Hiroaki Shimokawa

CIRCULATION　122　(21)　2010年11月

ISSN： 0009-7322
Importance of dual induction tests for coronary vasospasm and ventricular fibrillation in the decision-making for the management of patients with out-of-hospital cardiac arrest

Y. Takagi, S. Yasuda, J. Takahashi, M. Takeda, M. Nakayama, K. Ito, M. Hirose, Y. Wakayama, K. Fukuda, H. Shimokawa

EUROPEAN HEART JOURNAL　31　841-841　2010年9月

ISSN： 0195-668X
Rho-kinase Pathway Plays an Important Role in the Pathogenesis of Coronary Hyperconstricting Responses Induced by Drug-Eluting Stents in Pigs in vivo

Takashi Shiroto, Satoshi Yasuda, Ryuji Tsuburaya, Yoshitaka Ito, Jun Takahashi, Kenta Ito, Hatsue Ishibashi-Ueda, Hiroaki Shimokawa

CIRCULATION　120　(18)　S917-S917　2009年11月

ISSN： 0009-7322
Undernutrition is an Important Prognostic Factor of Cardiac Death in Patients With Diastolic Heart Failure

Jun Takahashi, Nobuyuki Shiba, Kotaro Nochioka, Hiroaki Shimokawa

CIRCULATION　120　(18)　S728-S728　2009年11月

ISSN： 0009-7322
Emerging Roles of Coronary Vasospasm and Ventricular Fibrillation in the Pathogenesis of Out-of-Hospital Cardiac Arrest

Yusuke Takagi, Satoshi Yasuda, Jun Takahashi, Morihiko Takeda, Masaharu Nakayama, Kenta Ito, Masanori Hirose, Yuji Wakayama, Koji Fukuda, Hiroaki Shimokawa

CIRCULATION　120　(18)　S651-S652　2009年11月

ISSN： 0009-7322
Increasing Trend of the Incidence of Acute Myocardial Infarction Over 30 Years in Japan: Lessons From the MIYAGI-AMI Registry Study

Toru Takii, Satoshi Yasuda, Yoshitaka To, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa

CIRCULATION　120　(18)　S430-S430　2009年11月

ISSN： 0009-7322
Continuous Renal Replacement Therapy in Patients With Acute Decompensated Heart Failure and Cardiorenal Syndrome

Jun Takahashi, Satoshi Yasuda, Toshinobu Sato, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　15　(7)　S171-S171　2009年9月

ISSN： 1071-9164
Characteristics of Japanese Patients With Acute Heart Failure; Risks of In-hospital Mortality

Masanobu Miura, Nobuyuki Shiba, Kotaro Nochioka, Jun Takahashi, Masaharu Nakayama, Shunsuke Tatebe, Haruka Kohno, Shizuka Osaki, Yoshihiro Fukumoto, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　15　(7)　S154-S154　2009年9月

ISSN： 1071-9164
Long-term Use of Diuretics May Be Associated With Increased Cardiac Events in Patients With Chronic Heart Failure

Nobuyuki Shiba, Kotaro Nochioka, Haruka Kohno, Jun Takahashi, Masanobu Miura, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　15　(7)　S167-S167　2009年9月

ISSN： 1071-9164
不安定プラークの診断は可能だったか

高橋潤, 福本義弘

日本心臓病学会誌 =Journal of cardiology. Japanese edition　3　(3)　258-262　2009年5月15日
出版者・発行元：日本心臓病学会
ISSN： 1882-4501
最新・薬物治療の実際狭心症の薬物療法

高橋潤, 下川宏明

MD　6　(5)　22-26　2009年5月
出版者・発行元：クリニックマガジン
OJ-238 Penetration Rate of Standard Treatment in Japanese Patients with Chronic Heart Failure : Interim Analysis of the CHART-2 Study(OJ40,Preventive Medicine/Epidemiology/Education (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Nochioka Kotaro, Shiba Nobuyuki, Takahashi Jun, Hirose Masanori, Shimokawa Hiroaki

Circulation journal : official journal of the Japanese Circulation Society　73　346-346　2009年3月1日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
ROLE OF RHO-KINASE IN THE PATHOGENESIS OF CORONARY HYPERCONSTRICTING RESPONSES INDUCED BY PACLITAXEL-ELUTING STENT

Takashi Shiroto, Satoshi Yasuda, Ryuji Tsuburaya, Yoshitaka Ito, Jun Takahashi, Kenta Ito, Hatsue Ishibashi-Ueda, Hiroaki Shimokawa

JOURNAL OF VASCULAR RESEARCH　46　123-123　2009年

ISSN： 1018-1172
IMPORTANCE OF DUAL INDUCTION TESTS FOR CORONARY VASOSPASM AND VENTRICULAR FIBRILLATION IN PATIENTS SURVIVED FROM OUT-OF-HOSPITAL CARDIAC ARREST

Yusuke Takagi, Satoshi Yasuda, Jun Takahashi, Morihiko Takeda, Masaharu Nakayama, Kenta Ito, Masanori Hirose, Yuji Wakayama, Koji Fukuda, Hiroaki Shimokawa

JOURNAL OF VASCULAR RESEARCH　46　126-126　2009年

ISSN： 1018-1172
PCPS管理中にヘパリン起因性血小板減少症(HIT)の合併が疑われた一例

大橋潤子, 安田聡, 高橋潤, 武田守彦, 中山雅晴, 伊藤健太, 下川宏明

ICUとCCU　33　(4)　335-335　2009年
出版者・発行元：医学図書出版(株)
ISSN： 0389-1194
虚血性心疾患の薬物療法 (特集内科診療ガイドライン活用法) -- (循環器)

高橋潤, 下川宏明

内科　102　(6)　1115-1122　2008年12月
出版者・発行元：南江堂
ISSN： 0022-1961
16) PCIに合併した冠動脈穿孔に対する治療方針の決定に心臓MDCTが有効だった一例(第146回日本循環器学会東北地方会)

高橋潤, 安田聡, 越田亮司, 中山雅晴, 伊藤健太, 多田智洋, 加賀谷豊, 下川宏明

Circulation journal : official journal of the Japanese Circulation Society　72　1054-1054　2008年10月20日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
6) 非心臓手術前に低肺機能のためPCI・OPCABによるハイブリット完全冠血行再建を施行した1例(第145回日本循環器学会東北地方会)

高橋潤, 安田聡, 越田亮司, 中山雅晴, 伊藤健太, 國生泰範, 多田智洋, 加賀谷豊, 下川宏明

Circulation journal : official journal of the Japanese Circulation Society　72　1020-1020　2008年10月20日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
5) ヨードアレルギー症例に対するガドリニウム造影剤を用いた冠動脈造影(第145回日本循環器学会東北地方会)

伊藤健太, 安田聡, 高橋潤, 越田亮司, 中山雅晴, 國生泰範, 多田智洋, 加賀谷豊, 下川宏明

Circulation journal : official journal of the Japanese Circulation Society　72　1020-1020　2008年10月20日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
2) サイファー留置後にincomplete stent appositionを合併しlate stent thrombosisを来した2症例の経験(第145回日本循環器学会東北地方会)

鈴木秀明, 越田亮司, 伊藤健太, 中山雅晴, 多田智洋, 國生泰範, 高橋潤, 安田聡, 加賀谷豊, 下川宏明

Circulation journal : official journal of the Japanese Circulation Society　72　1020-1020　2008年10月20日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
49) 日本人におけるメタボリックシンドローム診断の至適ウエスト周囲径とは? : CHART-2研究からの中間報告(第145回日本循環器学会東北地方会)

多田智洋, 柴信行, 松木美香, 高橋潤, 下川宏明

Circulation journal : official journal of the Japanese Circulation Society　72　1025-1025　2008年10月20日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
Rho-kinase Pathway Plays an Important Role in the Pathogenesis of Coronary Hyperconstricting Responses Induced by Drug-Eluting Stent

Takashi Shiroto, Satoshi Yasuda, Ryuji Tsuburaya, Yoshitaka Ito, Hatsue Ishibashi-Ueda, Kento Ito, Jun Takahashi, Hiroaki Shimokawa

CIRCULATION　118　(18)　S893-S893　2008年10月

ISSN： 0009-7322
Underuse of renin-angiotensin system inhibitors is associated with poor prognosis of heart failure patients with chronic kidney disease

Kotaro Nochioka, Nobuyuki Shiba, Haruka Kohno, Jun Takahashi, Masanori Hirose, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　14　(7)　S159-S159　2008年9月

ISSN： 1071-9164
FRS-087 What is the Optimal Waist Circumference Cut-point to Diagnose Metabolic Syndrome in Japanse Population? : Interim Analysis from the CHART-2 Study(New Insights into Metabolic Syndrome(01)(H),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Tada Tomohiro, Shiba Nobuyuki, Matsuki Mika, Takahashi Jun, Shimokawa Hiroaki

Circulation journal : official journal of the Japanese Circulation Society　72　166-166　2008年3月1日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
9 Large Cohort Studies for the Establishment of Guidelines of Chronic Heart Failure in Japan(Symposium 18 (SY-18) (H) How can we Make the Best Use of Japanese Evidences for Future Guidelines,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Shiba Nobuyuki, Matsuki Mika, Takahashi Jun, Hirose Masanori, Fukumoto Yoshihiro, Kagaya Yutaka, Shimokawa Hiroaki

Circulation journal : official journal of the Japanese Circulation Society　72　62-62　2008年3月1日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
PE-545 Undernutrition is an Important Prognostic Factor of Cardiac Death in Patients with Diastolic Heart Failure(Heart failure, clinical(12)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Takahashi Jun, Shiba Nobuyuki, Tada Tomohiro, Matsuki Mika, Shimokawa Hiroaki

Circulation journal : official journal of the Japanese Circulation Society　72　496-496　2008年3月1日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
PE-004 Significance of Basal Coronary Artery Tone in Patients with Vasospastic Angina : Analysis by Using Quantitative Coronary Angiography(Angina pectoris, basic/clinical(03)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Takahashi Jun, Yasuda Satoshi, Koshida Ryoji, Ito Kenta, Nakayama Masaharu, Tada Tomohiro, Kokusho Yasunori, Shimokawa Hiroaki

Circulation journal : official journal of the Japanese Circulation Society　72　361-361　2008年3月1日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
OE-393 Importance of Dual Induction Test for Coronary Vasospasm and Ventricular Fibrillation in Patients Survived from Out-of-Hospital Cardiac Arrest(Emergency care/CPR(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Takahashi Jun, Yasuda Satoshi, Koshida Ryoji, Kokusho Yasunori, Tada Tomohiro, Nakayama Masaharu, Ito Kenta, Shimokawa Hiroaki

Circulation journal : official journal of the Japanese Circulation Society　72　279-279　2008年3月1日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
OE-125 What Is the Optimal Therapeutic Target of Hemoglobin Level in Patients with Chronic Heart Failure? : Lessons from the CHART Study(Heart failure, clinical(02)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Tada Tomohiro, Shiba Nobuyuki, Matsuki Mika, Takahashi Jun, Hirose Masanori, Shimokawa Hiroaki

Circulation journal : official journal of the Japanese Circulation Society　72　211-211　2008年3月1日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
OE-214 Long-Time Mortality of Japanese Patients with Diastolic Heart Failure(Heart failure, clinical(03)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Tada Tomohiro, Shiba Nobuyuki, Matsuki Mika, Takahashi Jun, Shimokawa Hiroaki

Circulation journal : official journal of the Japanese Circulation Society　72　234-234　2008年3月1日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
9)狭心症状を呈した左冠動脈再建術後20年以上経過したBland White Garland症候群の2例(第143回日本循環器学会東北地方会)

太田有夕美, 高橋潤, 多田博子, 越田亮司, 中山雅晴, 伊藤健太, 安田聡, 柴信行, 小丸達也, 加賀谷豊, 下川宏明

Circulation journal : official journal of the Japanese Circulation Society　71　926-926　2007年10月20日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
32)血行動態の悪化した若年者拡張型心筋症例に対してPDE阻害剤が著効した1症例(第143回日本循環器学会東北地方会)

浅海泰栄, 高橋潤, 越田亮司, 國生泰範, 中山雅晴, 伊藤健太, 多田博子, 安田聡, 柴信行, 下川宏明

Circulation journal : official journal of the Japanese Circulation Society　71　928-928　2007年10月20日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
14)血栓塞栓による急性心筋梗塞を発症した先天性心疾患根治術後の2例(第143回日本循環器学会東北地方会)

國生泰範, 高橋潤, 越田亮司, 中山雅晴, 伊藤健太, 浅海泰栄, 安田聡, 柴信行, 小丸達也, 加賀谷豊, 下川宏明

Circulation journal : official journal of the Japanese Circulation Society　71　926-926　2007年10月20日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
11)Bystander CPRにより救命され,治療抵抗性を呈した冠攣縮性狭心症の一例(第144回日本循環器学会東北地方会)

國生泰範, 高橋潤, 菅井義尚, 伊藤健太, 中山雅晴, 越田亮司, 浅海泰栄, 安田聡, 下川宏明

Circulation journal : official journal of the Japanese Circulation Society　71　983-983　2007年10月20日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
41)拡張不全症例において栄養状態が予後に及ぼす影響(第144回日本循環器学会東北地方会)

高橋潤, 柴信行, 多田智洋, 下川宏明

Circulation journal : official journal of the Japanese Circulation Society　71　986-986　2007年10月20日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
Undernutrition is an important prognostic factor of cardiac death in patients with diastolic heart failure

J. Takahashi, N. Shiba, T. Tada, M. Matsuki, H. Shimokawa

EUROPEAN HEART JOURNAL　28　521-521　2007年9月

ISSN： 0195-668X
CHART研究 (特集心不全予防--その最前線を探る) -- (心不全の疫学を探る--日本発の日本人のための心不全エビデンス)

柴信行, 高橋潤, 松木美香

内科　99　(3)　410-414　2007年
出版者・発行元：南江堂
ISSN： 0022-1961
47)拡張障害を伴う心不全患者における貧血と突然死(第141回日本循環器学会東北地方会)

多田智洋, 柴信行, 篠崎毅, 高橋潤, 渡辺淳, 白土邦男, 下川宏明

Circulation journal : official journal of the Japanese Circulation Society　70　1132-1132　2006年10月20日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
43)アンジオテンシン変換酵素阻害薬またはアンジオテンシン受容体拮抗薬は拡張不全の予後を改善する(第141回日本循環器学会東北地方会)

高橋潤, 篠崎毅, 柴信行, 多田智洋, 下川宏明

Circulation journal : official journal of the Japanese Circulation Society　70　1132-1132　2006年10月20日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
25)急性冠症候群様に発症した好酸球性心筋炎の一例(第142回日本循環器学会東北地方会)

湊谷豊, 高橋潤, 中山雅晴, 遠藤秀晃, 菅井義尚, 若山裕司, 柴信行, 下川宏明

Circulation journal : official journal of the Japanese Circulation Society　70　1180-1180　2006年10月20日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
17)当科におけるCypher Stentの使用成績と再狭窄例の検討(第142回日本循環器学会東北地方会)

圓谷隆治, 越田亮司, 中山雅晴, 多田博子, 伊藤健太, 高橋潤, 安田聡, 柴信行, 小丸達也, 加賀谷豊, 下川宏明

Circulation journal : official journal of the Japanese Circulation Society　70　1179-1179　2006年10月20日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
Immoderate reduction in blood pressure may be associated with reduced survival in non-hypertensive patients with chronic heart failure

Nobuyuki Shiba, Mika Matsuki, Jun Takahashi, Jun Watanabe, Yutaka Kagaya, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　12　(8)　S182-S182　2006年10月

ISSN： 1071-9164
Depressed contractile reserve and impaired calcium handling of cardiac myocytes from chronically unloaded heart are ameliorated with low dose of thyroid hormone in rats

Kenta Ito, Yutaka Minatoya, Yutaka Kagaya, Yasuhide Asaumi, Morihiko Takeda, Masaharu Nakayama, Jun Takahashi, Hirokazu Yahagi, Atsushi Iguchi, Kunio Shirato, Hiroaki Shimokawa

CIRCULATION　114　(18)　668-668　2006年10月

ISSN： 0009-7322
Undernutrition is a significant prognostic factor in patients with diastolic heart failure

Jun Takahashi, Nobuyuki Shiba, Tomohiro Tada, Mika Matsuki, Hiroaki Shimokawa

JOURNAL OF CARDIAC FAILURE　12　(8)　S181-S181　2006年10月

ISSN： 1071-9164
Beta-blocker is effective in reducing cardiovascular events in patients with chronic heart failure complicated by atrial fibrillation

N Shiba, T Tada, T Shinozaki, K Fukuda, J Takahashi, J Watanabe

JOURNAL OF CARDIAC FAILURE　11　(9)　S294-S294　2005年12月

ISSN： 1071-9164
Anemia predicts sudden death in heart failure patients with preserved systolic function

T Tada, N Shiba, T Shinozaki, J Takahashi, J Watanabe

JOURNAL OF CARDIAC FAILURE　11　(9)　S296-S296　2005年12月

ISSN： 1071-9164
FDG-PETが診断に有効であった心サルコイドーシスの2症例(第140回日本循環器学会東北地方会)

高橋潤, 渡辺淳, 篠崎毅, 柴信行, 福田浩二

Circulation journal : official journal of the Japanese Circulation Society　69　954-954　2005年10月20日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
心サルコイドーシス症における心不全はステロイド療法により改善するか?(第139回日本循環器学会東北地方会)

高橋潤, 篠崎毅, 渡辺淳, 柴信行, 福田浩二, 白土邦男

Circulation journal : official journal of the Japanese Circulation Society　69　898-898　2005年10月20日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
慢性心不全の予後予測因子についての研究 : BNPとpVO_2の関連(第139回日本循環器学会東北地方会)

柴信行, 渡辺淳, 福田浩二, 高橋潤, 古関義人, 白土邦男

Circulation journal : official journal of the Japanese Circulation Society　69　898-898　2005年10月20日
出版者・発行元：社団法人日本循環器学会
ISSN： 1346-9843
Anemia predicts sudden death in heart failure patients with preserved systolic function

T Tada, N Shiba, T Shinozaki, J Takahashi, J Watanabe

CIRCULATION　112　(17)　U516-U516　2005年10月

ISSN： 0009-7322
一次予防的に植え込んだ植え込み型除細動器(ICD)が初発の頻脈性心室性不整脈に対して的確に作動した閉塞性肥大型心筋症の若年男性の1例

清水亜希子, 篠崎毅, 遠藤秀晃, 佐藤公雄, 多田博子, 深堀耕平, 広瀬尚徳, 高橋孝典, 大友淳, 若山裕司, 沼口裕隆, 苅部明彦, 三浦昌人, 福地満正, 渡辺淳, 白土邦男

心臓　36　(Suppl.3)　29-34　2004年7月
出版者・発行元： (公財)日本心臓財団
DOI： 10.11281/shinzo1969.36.Supplement3_29 　

ISSN： 0586-4488

eISSN： 2186-3016
家族によるCPRにて救命し,ICD植え込み後も頻回の心室細動を認める特発性心室細動の1例

深堀耕平, 篠崎毅, 遠藤秀晃, 佐藤公雄, 多田博子, 広瀬尚徳, 高橋孝典, 大友淳, 熊谷浩司, 菅井義尚, 杉江正, 若山裕司, 苅部明彦, 沼口裕隆, 三浦昌人, 福地満正, 渡辺淳, 白土邦男

心臓　35　(Suppl.3)　32-36　2003年9月
出版者・発行元： (公財)日本心臓財団
DOI： 10.11281/shinzo1969.35.Supplement3_32 　

ISSN： 0586-4488

eISSN： 2186-3016
Deficiency of CD38-cyclic ADP-ribose signaling system elicits the upregulation of genes related to Ca2+ handling

J Takahashi, Y Kagaya, J Ohta, S Isoyama, M Miura, C Takahashi, Y Sugai, Kato, I, S Takasawa, H Okamoto, K Shirato

CIRCULATION　102　(18)　7-7　2000年10月

ISSN： 0009-7322
カテーテルによる血栓吸引術により救命し得た重症肺血栓塞栓症の2例

洞口淳, 加藤敦, 谷川俊了, 柴信行, 堀口聡, 杉村彰彦, 高橋潤, 金澤正晴, 白土邦男

日本内科学会雑誌　89　(10)　2186-2188　2000年
出版者・発行元： The Japanese Society of Internal Medicine
DOI： 10.2169/naika.89.2186 　

ISSN： 0021-5384 1883-2083

詳細を見る詳細を閉じる

症例1は77歳女性.胸部圧迫感,呼吸困難を主訴に来院.症例2は63歳女性.労作時の息切れを主訴に来院.両症例とも緊急心臓カテーテル検査を施行し両側肺動脈に造影欠損像を認め肺血栓塞栓症と診断.血栓溶解療法を開始したがショック状態となったためカテーテルを用いて血栓吸引術を施行,短時間でショックから離脱,安定した血行動態が得られた.重症肺血栓塞栓症に対しては血栓吸引療法が極めて有効であると考え報告した.
48)重症心不全を呈した甲状腺機能亢進症の一例

高橋潤, 加藤敦, 柴信行, 堀口聡, 杉村彰彦, 金澤正晴, 船越正行

Japanese circulation journal　63　(2)　700-700　1999年8月20日
出版者・発行元：社団法人日本循環器学会
ISSN： 0047-1828

︎全件表示 ︎最初の5件までを表示

講演・口頭発表等 38

Continuous Renal Replacement Therapy for the Treatment of Acute Decompensated Heart Failure and Cardio-Renal Syndrome 国際会議

Jun Takahashi, Satoshi Yasuda, Nobuyuki Shiba, Mariko Miyazaki and, Hiroaki Shimokawa

アメリカ心臓協会学術集会2011　2011年11月12日
ncreased Incidence of Heart Failure in the Tohoku Earthquake -Initial Report from the Tohoku University Hospital-

Jun Takahashi, Satoshi Yasuda, Masaharu Nakayama, Yoshitaka Ito, Kenta Ito, Koji Fukuda, Yoshihiro Fukumoto, Nobuyuki Shiba, Hiroaki Shimokawa

第15回日本心不全学会　2011年10月15日
冠動脈インターベンションの現状と問題点

高橋潤, 下川宏明

第3回Brain and Heart Forum　2010年9月30日
心腎症候群を合併した急性心不全症例における持続腎代替療法の検討

高橋潤, 安田聡, 柴信行, 中山昌明, 下川宏明

第58回日本心臓病学会学術集会　2010年9月17日
A hybrid strategy with percutaneous coil embolization and re-CABG for giant coronary aneurysm in a patient undergone Dor procedure

Jun Takahashi, Satoshi Yasuda, Morihiko Takeda, Yoshitaka Ito, Ryuji Tsuburaya, Yusuke Takagi, Katsuhiko Oda, Shunsuke Kawamoto, Kei Takase, Kouichi Tabayashi, Hiroaki Shimokawa

第19回日本心血管インターベンション治療学会　2010年8月22日
巨大冠動脈瘤に対し冠動脈バイパス術と冠動脈塞栓術によるハイブリット治療を施行した１例

円谷隆二, 高橋潤, 安田聡, 小田克彦, 川本俊輔, 高瀬圭, 武田守彦, 伊藤愛剛, 高木祐介, 中山雅晴, 伊藤健太, 下川宏明

第１５０回日本循環器学会東北地方会　2010年6月5日
悪性リンパ腫化学療法後に不安定化を繰り返した難治性冠攣縮性狭心症の1例

円谷隆治, 高橋潤, 安田聡, 伊藤愛剛, 高木祐介, 武田守彦, 中山雅晴, 伊藤健太, 竹内雅治, 下川宏明

第１５０回日本循環器学会東北地方会　2010年6月5日
OCTで冠動脈過収縮を観察し得た冠攣縮性不安定狭心症の1例

高橋潤, 武田守彦, 安田聡, 伊藤愛剛, 円谷隆二, 高木祐介, 中山雅晴, 伊藤健太, 下川宏明

第14回東北心血管イメージング研究会　2010年3月20日
SLEに合併した巨大冠動脈瘤に対し冠動脈バイパス術と冠動脈塞栓術によるハイブリット治療を施行した１例

高橋潤, 安田聡, 小田克彦, 川本俊輔, 高瀬圭, 武田守彦, 伊藤愛剛, 高木祐介, 中山雅晴, 伊藤健太, 下川宏明

第27回日本心血管インターベンション治療学会(CVIT)東北地方会　2010年1月23日
Undernutrition is an Important Prognostic Factor of Cardiac Death in Patients 国際会議

Jun Takahashi, Nobuyuki Shiba, Kotaro Nochioka, Hiroaki Shimokawa

第82回米国心臓協会学術集会　2009年11月14日
心腎症候群を合併した急性心不全症例における持続血液ろ過透析療法の効果

高橋潤, 安田聡, 佐藤寿伸, 下川宏明

第13回日本心不全学会総会　2009年10月30日
多枝攣縮に伴う多様な心電図変化と特異なMRI所見を伴った

佐藤直実, 高橋潤, 安田聡, 瀧井暢, 武田守彦, 中山雅晴, 伊藤健太, 高木祐介, 下川宏明

第57回日本心臓病学会総会　2009年9月18日
閉経前女性に認められた冠微小血管性狭心症の1例

宮道沙織, 高橋潤, 安田聡, 武田守彦, 中山雅晴, 伊藤健太, 伊藤愛剛, 瀧井暢, 高木祐介, 下川宏明

第148回日本循環器学会東北地方会　2009年6月6日
Co-existence of coronary vasospasm and ventricular fibrillation in patients survived from out-of-hospital cardiac arrest

Takahashi J, Yasuda S, Takagi Y, Nakayama M, Ito K, Takeda M, Hirose M, Wakayama Y, Fukuda K, Shimokawa H

第７３回日本循環器学会学術集会　2009年3月20日
多枝攣縮に伴う多様な心電図変化と特異なMRI所見を呈した急性心筋梗塞症例

山田友里恵, 高橋潤, 安田聡, 瀧井暢, 中野誠, 高橋貴久代, 武田守彦, 中山雅晴, 伊藤健太, 下川宏明

第１４７回日本循環器学会東北地方会　2009年2月14日
ヘパリン起因性血小板減少症・血栓症によると思われる急性心筋梗塞をPCI直前に発症した１例

山田友里恵, 高橋潤, 安田聡, 瀧井暢, 高木祐介, 武田守彦, 中山雅晴, 伊藤健太, 下川宏明

第１４７回日本循環器学会東北地方会　2009年2月14日
多枝攣縮に伴う多様な心電図変化と特異なMRI所見を伴った急性心筋梗塞症例

山田友里恵, 高橋潤, 安田聡, 瀧井暢, 中野誠, 高橋貴久代, 武田守彦, 中山雅晴, 伊藤健太, 下川宏明

第１８６回日本内科学会東北地方会　2008年9月20日
PCIに合併した冠動脈穿孔に対する治療方針の決定に心臓MDCTが有効であった１例

高橋潤, 安田聡, 越田亮司, 中山雅晴, 伊藤健太, 多田智洋, 加賀谷豊, 下川宏明

第１４６回日本循環器学会東北地方会　2008年6月7日
Importance of Dual Induction Test for Coronary Vasospasm and Ventricular Fibrillation in Patients Survived from Out-of-Hospital Cardiac Arrest

un Takahashi, Satoshi Yasuda, Ryoji Koshida, Yasunori Kokusyou, Tomohiro Tada, Masaharu Nakayama, Kenta Ito, Hiroaki Shimokawa

第72回日本循環器学会総会　2008年3月28日
Undernutrition is an Important Prognostic Factor of Cardiac Death in Patients with Diastolic Heart Failure

Jun Takahashi, Nobuyuki Shiba, Tomohiro Tada, Mika Matsuki, Hiroaki Shimokawa

第72回日本循環器学会総会　2008年3月28日
Significance of Basal Coronary Artery Tone in Patients with Vasospastic Angina: Analysis by Using Quantitative Coronary Angiography

Jun Takahashi, Satoshi Yasuda, Ryoji Koshida, Yasunori Kokusho, Tomohiro Tada, Masaharu Nakayama, Kenta Ito, Hiroaki Shimokawa

第72回日本循環器学会総会　2008年3月28日
非心臓手術前に低肺機能のためPCI・OPCABによるハイブリット完全冠血行再建を施行した1例

高橋潤, 安田聡, 越田亮司, 中山雅晴, 伊藤健太, 国生範泰, 多田智洋, 加賀谷豊, 下川宏明

第145回日本循環器学会東北地方会　2008年2月23日
Large lumen vesselに対して薬剤溶出性ステントは必要か？ —ベアメタルステントとの再狭窄予防効果に関する比較検討—

高橋潤, 安田聡, 下川宏明

第55回日本心臓病学会　2007年9月10日
Prognostic Impact of Angiotensin-Converting Enzyme Inhibitor and/or Angiotensin Receptor Blocker in Patients with Diastolic Heart Failure

Jun Takahashi, Nobuyuki Shiba, Tomohiro Tada, Hiroaki Shimokawa

第11回日本心不全学会　2007年9月9日
Undernutrition Is an Important Prognostic Factor of Cardiac Death in Patients with Diastolic Heart Failure 国際会議

Jun Takahashi, Nobuyuki Shiba, Tomohiro Tada, Mika Matsuki, Hiroaki Shimokawa

ESC Congress 2007　2007年9月2日
院外心停止に冠攣縮の関与が疑われた一例

高橋潤, 安田聡, 下川宏明

第2回冠攣縮研究会　2007年7月28日
拡張不全症例において栄養状態が予後に及ぼす影響

高橋潤, 柴信行, 多田智洋, 下川宏明

第144回日本循環器学会東北地方会　2007年6月9日
4.0mm ベアメタルステントと3.5mm 薬剤溶出性ステントの再狭窄予防効果の比較検討

高橋潤, 安田聡, 越田亮司, 中山雅晴, 多田博子, 伊藤健太, 下川宏明

第５５回日本循環器学会総会　2007年3月14日
狭心症状を呈した左冠動脈再建術後２０年以上経過したBland White Garland症候群の２例

太田有夕美, 高橋潤, 多田博子, 越田亮司, 中山雅晴, 伊藤健太, 安田聡, 柴信行, 小丸達也, 加賀谷豊, 下川宏明

第１４３回日本循環器学会東北地方会　2007年2月3日
4.0mmベアメタルステントと3.5mm薬剤溶出性ステントの再狭窄予防効果の比較検討

高橋潤, 安田聡, 越田亮司, 中山雅晴, 伊藤健太, 浅海泰栄, 國生泰範, 柴信行, 小丸達也, 加賀谷豊, 下川宏明

第２１回日本心血管インターベンション学会東北地方会　2007年1月27日
慢性心不全例におけるアンジオテンシン変換酵素阻害薬・アンジオテンシン受容体拮抗薬の予後改善効果 -CHART研究における検討-

高橋潤, 柴信行, 篠崎毅, 下川宏明

第54回日本心臓病学会　2006年9月25日
拡張不全症例におけるアンジオテンシン変換酵素阻害薬・アンジオテンシン受容体拮抗薬の予後改善効果

高橋潤, 篠崎, 毅柴, 信行, 多田, 智洋, 渡辺, 淳, 白土, 邦男, 下川宏明

第70回日本循環器学会総会　2006年3月24日
特徴的なIVUS像を呈し、2度のPCIを施行した冠動脈炎の一例

高橋潤, 越田亮司, 中山雅晴, 柴信行, 下川宏明

第10回東北IVUS研究会　2006年3月11日
サイファーステント留置後，亜急性期にステント内血栓を認め，慢性期に冠動脈瘤を形成した慢性完全閉塞性病変の1例

高橋潤, 柴, 信行, 越田, 亮司, 中山, 雅晴, 下川宏明

第178回内科学会東北地方会　2006年2月18日
アンジオテンシン変換酵素阻害薬・アンジオテンシン受容体拮抗薬は拡張不全の予後を改善する

高橋潤, 篠崎, 毅柴, 信行, 多田, 智洋, 下川宏明

第141回日本循環器学会東北地方会　2006年2月4日
ガイディングカテーテルにより生じた冠動脈解離に対してステント7本用いてbailoutした1例

高橋潤

心臓カテーテルカンファランス　2005年10月4日
心サルコイドーシス症による心不全はステロイド療法により改善するか？

高橋潤, 篠崎, 毅, 渡辺, 淳, 柴, 信行, 福田, 浩二, 白土邦男

第53回日本心臓病学会　2005年9月19日
CYPHER留置１週間後にステント内血栓を認めた１例

高橋潤, 岩渕, 薫柴, 信行, 越田, 亮司, 高橋, 克明, 伊藤, 健太, 中山, 雅晴, 国生, 泰範, 小丸, 達也, 加賀谷豊

インターベンション学会東北地方会　2005年7月23日

︎全件表示 ︎最初の5件までを表示

共同研究・競争的資金等の研究課題 11

左室収縮能が保たれた心不全におけるSGLT2阻害薬の冠微小血管機能に及ぼす効果

高橋潤

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2022年4月1日～ 2025年3月31日
Rho-kinase活性に着目した微小血管狭心症の新規治療法及び治療戦略の確立

白戸崇, 高橋潤, 佐藤公雄

2021年4月1日～ 2024年3月31日

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心表面冠動脈に動脈硬化による器質的狭窄あるいは冠動脈攣縮を認めないものの、狭心症症状を有する症例は微小血管狭心症と診断される。微小血管狭心症では硝酸薬が有効な症例は50％以下でカルシウム拮抗薬に治療抵抗性の症例がまれでなく、未だ有効な治療法が確立されていないことから、患者のQOL低下と医療費増大は循環器診療における課題である。微小血管狭心症の病態機序として冠微小循環障害が提唱されており、その病態機序はRho-kinase活性化を介した内皮機能障害、平滑筋過収縮の関与が想定されている。本基盤研究では、狭心症症状を有し待機的心臓カテーテル検査目的で東北大学病院に入院する研究対象者について、Rho-kinase経路の修飾候補薬であるスタチン、メトホルミンの投与前後で、Rho-kinase活性、冠微小血管障害の指標(CFR・IMR)、血中バイオマーカー、シアトル狭心症質問票による自覚症状の推移を収集し、それらの関連を多面的に検討することで、Rho-kinase活性に立脚した微小血管狭心症の新規治療戦略を確立することを目的としていた。令和3年度は、研究分担者である高橋潤が令和3年度よりAMED研究「非閉塞性冠動脈疾患患者における冠動脈機能の性差に関する研究開発」を開始したことで、研究対象者が重複することとなり、本基盤研究で実施を予定していたRho-kinase経路の修飾候補薬による介入は、AMED研究の追跡調査終了後まで困難な状況となった。したがって、令和３年度はAMED研究に登録された微小血管狭心症患者のデータを収集するとともに、2016年から2019年に東北大学病院において微小血管狭心症と診断された172名について、心臓カテーテル検査実施時のスタチン・メトホルミンの内服状況とCFR・IMRの値を収集した。
新世代冠動脈デバイスの血管機能に及ぼす効果及びその臨床における意義についての研究

圓谷隆治, 高橋潤, 下川宏明, 松本泰治, 羽尾清貴, 西宮健介, 宇塚裕紀, 大山宗馬, 天水宏和, 土屋聡, 菊地翼

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2016年4月1日～ 2019年3月31日

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本研究開始にあたり、当院の倫理委員会より非無作為の観察研究での条件付き承認となった。これにより当施設でステント留置後も胸痛がありアセチルコリン負荷試験を行った症例を対象に、後ろ向きに血管反応を解析し、ポリマー吸収性ステント(BP-DES)と非吸収性のステント(DP-DES)での比較を解析を行った。OCTの検討において、留置後の冠動脈過収縮反応に関与しているVasa vasorumの変化量は、BP-DES群はDP-DES群に比較して有意に大きかった。内腔や血管径を含む形態学的指標は2群で同等であった。また前向き無作為割り付け試験について審議を重ね2018年に承認され、現在患者登録中である。
難治性冠攣縮性狭心症患者における冠微小循環障害バイオマーカーに関する検討

高橋潤, 下川宏明, 小鷹悠二, 二瓶太郎

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2016年4月1日～ 2019年3月31日

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本研究の成果は以下の2点が挙げられる。一つ目はこれまで長期予後を判断する指標が確立されていなかった冠攣縮性狭心症においてのRhoキナーゼ活性が長期予後新規バイオマーカーであることを同定したことである。二つ目は強力な血管収縮作動作用と血小板凝集作用を有する血管作動物質として古くから知られているセロトニンの血漿内濃度が、治療抵抗性を示すことが報告されている微小血管型狭心症の診断バイオマーカーであることを世界に先駆けて明らかにしたことである。
医療の質向上と発症予測モデル開発のための包括的循環器疾患登録プラットフォーム構築

安田聡, 高山守正, 高橋潤, 住吉徹哉, 小川久雄, 松田晋哉, 荻野均, 飯原弘二, 小室一成, 下川宏明, 岡村智教, 宮本恵宏, 西村邦宏, 宍戸稔聡, 小島淳

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：National Cardiovascular Center Research Institute

2014年4月1日～ 2017年3月31日

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本研究では1) DPC(診断群分類包括評価)情報を用いた中核的循環器治療施設における疾患登録とQIによるQuality of Care研究、2) 日本の代表的地域レジストリを用いた疾患登録データベースによる循環器疾患の重篤度予測、3)米国NDCR(National Cardiovascular Data Registry)を手本としたIT化による半自動抽出システムの仕様開発、これらを基に包括的循環器疾患登録プラットフォームを整備した。
冠攣縮の日内変動におけるRhoキナーゼ活性の関与

高橋潤, 下川宏明

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2013年4月1日～ 2016年3月31日

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本研究の目的は冠攣縮性狭心症（VSA）患者における日内変動のメカニズムを明らかにすることである。冠攣縮誘発試験を施行した連続49例において白血球Rho-kinase活性を1日3回（12時、21時、6時）測定した。VSA群のRho-kinase活性は6時に最高値を示し、対照群より有意に高値であり、両群間のRho-kinase活性変動パターンは異なっていた。さらにVSA群の白血球Rho-kinase活性は冠動脈basal tone、収縮反応と正相関し、交感神経活性とは負の相関を認めた。以上から、Rho-kinase活性はVSA発作の日内変動を生み出す機序に関与する可能性が示唆された。
サイクロフィリンを基盤とする心血管病の成因解明と新しい診断・予防・治療法の開発

佐藤公雄, 高橋潤, 福本義弘

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Tohoku University

2012年4月1日～ 2016年3月31日

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心血管病発症における酸化ストレス分泌蛋白 Cyclophilin A (CyPA)の基礎的・臨床的有用性については、研究目的をほぼ達成できた。遺伝子改変動物を用いた基礎研究を継続し、CyPAが動脈硬化・大動脈瘤・心不全・肺高血圧症にとって重要な促進蛋白であることを証明した。また、基礎研究の成果を昇華させるべく、心血管病患者由来の組織や血清を用いた血清学的診断法の開発を行った。特に、冠動脈疾患や肺高血圧症患者の重症度に応じて、血漿中CyPA濃度が高くなることや、CyPA高値群は長期生命予後が著しく悪いことを証明した。助成期間内に計42演題の国際学会発表および計36本の英文論文発表を行った。
新型薬剤溶出性ステントの血管機能異常発現に与える効果についての検討

圓谷隆治, 下川宏明, 安田聡, 西宮健介, 松本泰治, 高橋潤

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Young Scientists (B)

研究機関：Tohoku University

2012年4月1日～ 2015年3月31日

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新世代薬剤溶出ステントであるエベロリムス溶出ステント(EES)及びバイオリムス溶出ステント(BES）留置後の血管機能について検討し、第1世代薬剤溶出ステントで認められた異常血管反応がでは改善するがEESにおいては改善が認められない事を明らかにした。この機序として、免疫組織学的検討によりDES留置後の炎症反応および冠動脈外膜のVasa vasorum（VV）の増生がBESにおいて抑制されていることを明らかにし、更に光干渉断層装置を用いて生体内でVVが評価可能であることをブタモデルおよび臨床研究にて明らかにした。
末梢血多核白血球Ｒｈｏキナーゼ測定：冠攣縮性狭心症の新たなバイオマーカーの開発

安田聡, 下川宏明, 高橋潤

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

2011年～ 2013年

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末梢血多核白血球でのRhoキナーゼ活性測定が、冠攣縮性狭心症(およびその関連疾患)の診断や活動性評価に有用であるかについて検討した。アセチルコリン誘発試験陽性群では、陰性群に比し有意にRhoキナーゼ活性が上昇していた。また、Rhoキナーゼ活性はストレス（東日本大震災前後の比較、PTSDスコアとの比較）とよく相関し、かつ冠攣縮性狭心症に特徴的な日内変動も認められた。以上より末梢血好中球Rhoキナーゼ活性は疾患活動性を反映したバイオマーカーとして今後更なる研究が期待される。
拡張不全型心不全の実態解明と効果的治療戦略の確立

高橋潤, 下川宏明

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2010年～ 2012年

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本研究では我々が行っている観察研究(CHART研究)のデータベースを用いて、ステージC/Dの拡張不全例とステージBの軽症慢性心不全例においてCONUTスコアによる栄養状態評価を行い、栄養状態が予後に及ぼす影響を検討した。その結果、ステージC/D拡張不全型心不全、ステージB軽症慢性心不全の両者において栄養不良状態は心臓死の独立規定因子であることが示された。慢性心不全は軽症の段階から栄養状態に留意することが重要であり、栄養状態の改善は拡張不全型心不全治療の新たなターゲットとなる可能性が示唆された。
肺高血圧症に対する骨髄由来前駆細胞を用いた新しい遺伝子細胞治療法に関する基礎研究

鈴木潤, 渡辺淳, 苅部明彦, 高橋潤, 鈴木潤

2004年～ 2005年

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肺高血圧症における骨髄由来細胞の肺動脈リモデリングへの寄与に関する検討を行った。骨髄置換によってキメラマウスを作成し、慢性的な低酸素(O_210%)下で肺高血圧を誘導した。X-gal染色及び蛍光免疫染色によって、骨髄由来の細胞が肺血管内皮及び平滑筋へ分化することを確認した。さらに、低酸素下ではFlk-1^+/c-kit^+細胞が末梢血中で著しく増加しており、このFlk-1^+/c-kit^+細胞をFACSで純粋に採取し低酸素下で培養すると、平滑筋系細胞へ分化することを確認した(論文投稿中)。さらに、関連研究としてエリスロポイエチン受容体(EpoR)欠損マウスを用いた実験を行った。本来、エリスロポイエチン(Epo)は造血因子であるが、最近では心筋や血管内皮にもその受容体(EpoR)が発現していることが報告され、心血管系組織の保護に役立つと考えられ始めている。そこで、肺血管内皮でのEpoRのシグナルを欠損させた特殊なマウスを作成し、肺高血圧症および肺血管リモデリングが進行しやすいことを確認した(Circulation 2006;113:1442-1450)。

︎全件表示 ︎最初の5件までを表示