研究者詳細

顔写真

ヒラノ　マサハル
平野　雅春
Masaharu Hirano
所属
大学院医学系研究科　超早期画像診断共同研究講座
職名
准教授
学位

  • 博士（医学）（東京医科大学）

e-Rad 研究者番号
10317886

所属学協会 6

  • 日本磁気共鳴医学会

  • 日本医学放射線学会

  • 日本内科学会

  • 心血管画像動態学会

  • 日本循環器学会

  • 日本心臓病学会

︎全件表示 ︎最初の5件までを表示

研究分野 1

  • ライフサイエンス / 循環器内科学 / 循環器画像診断

論文 39

  1. Effects of β‒blocker administration on cardiac function: a coronary computed tomography angiography study. 国際誌

    Reiji Kokubo, Masaharu Hirano, Yu Tajima, Daisuke Yunaiyama, Kazuhiro Saito

    Current medical imaging　2022年5月18日

    DOI： 10.2174/1573405618666220518104929 　

    詳細を見る 詳細を閉じる

    BACKGROUND: β-blockers are widely used for lowering heart rate (HR) during coronary computed tomography angiography (CCTA); however, they should be used with caution for patients with heart failure as they may have a negative inotropic effect. OBJECTIVE: To clarify the effects of β-blockers (oral and intravenous injection) on cardiac function using CCTA. METHODS: A total of 244 patients (men: women = 166: 78; mean age, 64.4 years old) suspected of having ischemic cardiac disease and had undergone echocardiography within 3 months before and after CCTA were included in the study. Systematic errors in ejection fraction (EF) were corrected for, by calculating ΔEF from the EF difference between echocardiography and CCTA in patients not using β-blockers. Univariate and multivariate analyses were performed for factors affecting ∆EF. In addition, HR between, before, and during CCTA were compared by Wilcoxon's test. RESULTS: Temporary oral or intravenous administration of β-blockers at the CCTA had no significant effects on EF (p = 0.70), whereas HR was significantly decreased (p < 0.001). However, regular administration of β-blockers increase the EF on CCTA. CONCLUSION: The administration of β-blockers immediately before CCTA affects HR but not EF. Premedication with β-blockers can be safely used for patients who undergo CCTA, and CCTA is useful for EF evaluation, independent of the use of β-blockers.

  2. Effect of Landiolol Hydrochloride on Hemodynamics in a Histamine-Induced Shock Model

    Hirano, M., Okamura, T., Nagano, T., Nonaka, S., Shiroya, T.

    Drugs in R and D　21　(3)　2021年

    DOI： 10.1007/s40268-021-00354-3 　

    ISSN：1179-6901 1174-5886

  3. Coronary arterial spasm detected by coronary computed tomography angiography and confirmed by intravascular ultrasound

    Nakayama, M., Hirano, M., Goto, S., Watanabe, A., Uchiyama, T.

    Radiology Case Reports　13　(1)　2018年

    DOI： 10.1016/j.radcr.2017.09.002 　

    ISSN：1930-0433

  4. Coronary plaque characteristics in computed tomography and 2-year outcomes: The PREDICT study

    Yamamoto, H., Kihara, Y., Kitagawa, T., Ohashi, N., Kunita, E., Iwanaga, Y., Kobuke, K., Miyazaki, S., Kawasaki, T., Fujimoto, S., Daida, H., Fujii, T., Sato, A., Okimoto, T., Kuribayashi, S., Utsunomiya, H., Senoo, A., Matsunaga, E., Takamura, K., Kinoshita, R., Hayashi, Y., Himeno, H., Kondo, T., Fujimoto, S., Yamashina, A., Hirano, M., Ando, K., Yamaji, K., Inoue, N., Dote, K., Kato, M., Sasaki, S., Kawamura, M., Oshima, K., Hirayama, A., Yoda, S., Yoshino, H., Ishiguro, H., Doi, O., Fukuda, S., Shimada, K., Nao, T., Tanabe, K., Mochizuki, T., Kurata, A., Morishita, H., Matsumoto, N., Ohta, H.

    Journal of Cardiovascular Computed Tomography　12　(5)　2018年

    DOI： 10.1016/j.jcct.2018.07.001 　

    ISSN：1876-861X 1934-5925

  5. Detection of left ventricular regional dysfunction and myocardial abnormalities using complementary cardiac magnetic resonance imaging in patients with systemic sclerosis without cardiac symptoms: A pilot study

    Kobayashi, Y., Kobayashi, H., Giles, J.T., Yokoe, I., Hirano, M., Nakajima, Y., Takei, M.

    Internal Medicine　55　(3)　2016年

    DOI： 10.2169/internalmedicine.55.4441 　

    ISSN：1349-7235 0918-2918

  6. Radiation-dose-lowering effects of landiolol hydrochloride in coronary angiography using computed tomography (DELIGHT): A prospective multicenter study

    Kido, T., Mochizuki, T., Hirano, M., Yamada, Y., Tanaka, R., Kanzaki, S., Higashi, M., Jinzaki, M., Yoshioka, K., Kuribayashi, S.

    Circulation Journal　80　(5)　2016年

    DOI： 10.1253/circj.CJ-15-0962 　

    ISSN：1347-4820 1346-9843

  7. Association of tocilizumab treatment with changes in measures of regional left ventricular function in rheumatoid arthritis, as assessed by cardiac magnetic resonance imaging

    Kobayashi, Y., Kobayashi, H., Giles, J.T., Hirano, M., Nakajima, Y., Takei, M.

    International Journal of Rheumatic Diseases　19　(11)　2016年

    DOI： 10.1111/1756-185X.12632 　

    ISSN：1756-185X 1756-1841

  8. A randomized, double-blind, placebo-controlled, phase III study of the short-acting β1-adrenergic receptor blocker Landiolol hydrochloride for coronary computed tomography angiography in Japanese patients with suspected ischemic cardiac disease

    Hirano, M., Yamashina, A., Hara, K., Ikari, Y., Jinzaki, M., Iino, M., Yamaguchi, T., Tanimoto, M., Kuribayashi, S.

    Clinical Drug Investigation　34　(1)　2014年

    DOI： 10.1007/s40261-013-0149-y 　

    ISSN：1179-1918 1173-2563

  9. Rationale and design of the PREDICT (Plaque Registration and Evaluation Detected In Computed Tomography) registry

    Yamamoto, H., Awai, K., Kuribayashi, S., Kihara, Y., Ohashi, N., Utsunomiya, H., Miyazaki, S., Kobuke, K., Kawasaki, T., Daida, H., Matsunaga, E., Kinoshita, R., Fujii, T., Tomohiro, Y., Kunita, E., Sato, A., Hayashi, Y., Okimoto, T., Himeno, H., Yano, H., Kondo, T., Fujimoto, S., Yamashina, A., Hirano, M., Yokoi, Y., Yamaji, K., Inoue, N., Dote, K., Kato, M., Sasaki, S., Kawamura, M., Yoshino, H., Ishiguro, H., Ikeda, S., Hirayama, A., Fujii, N., Matsumoto, N., Doi, O., Fukuda, S., Shimada, K., Miura, T., Nawa, T., Tanabe, K., Mochizuki, T., Kurata, A., Morishita, H., Sato, Y., Ohta, H.

    Journal of Cardiovascular Computed Tomography　8　(2)　2014年

    DOI： 10.1016/j.jcct.2013.12.004 　

    ISSN：1876-861X 1934-5925

  10. A Multicenter, Open-Label Study of an Intravenous Short-Acting β1-Adrenergic Receptor Antagonist Landiolol Hydrochloride for Coronary Computed Tomography Angiography by 16-Slice Multi-Detector Computed Tomography in Japanese Patients with Suspected Ischemic Cardiac Disease

    Hirano, M., Yamashina, A., Hara, K., Ikari, Y., Jinzaki, M., Iino, M., Yamaguchi, T., Tanimoto, M., Kuribayashi, S.

    Drugs in R and D　14　(3)　2014年

    DOI： 10.1007/s40268-014-0056-6 　

    ISSN：1179-6901 1174-5886

  11. Left ventricular regional dysfunction using cardiac magnetic resonance imaging in rheumatoid arthritis patients without cardiac symptoms: Comparison between methotrexate and biologics treatment groups

    Kobayashi, Y., Kobayashi, H., Hirano, M., Giles, J.T.

    Journal of Rheumatology　41　(7)　2014年

    DOI： 10.3899/jrheum.121363 　

    ISSN：1499-2752 0315-162X

  12. Prediction of severe cardiac involvement by fundus lesion in sarcoidosis

    Umazume, A., Kezuka, T., Okunuki, Y., Ooshita, M., Usui, Y., Hirano, M., Yamashina, A., Goto, H.

    Japanese Journal of Ophthalmology　58　(1)　2014年

    DOI： 10.1007/s10384-013-0288-y 　

    ISSN：0021-5155 1613-2246

  13. Cost minimization analysis of beta-blocker at the time of CT imaging for suspected of coronary heart disease in Japan

    Igarashi, A., Fujito, K., Hirano, M., Fukuda, T.

    Journal of Medical Economics　17　(2)　2014年

    DOI： 10.3111/13696998.2013.877021 　

    ISSN：1369-6998 1941-837X

  14. A randomized, double-blind, placebo-controlled, phase II dose-finding study of the short acting β1-blocker, landiolol hydrochloride, in patients with suspected ischemic cardiac disease

    Jinzaki, M., Hirano, M., Hara, K., Suzuki, T., Yamashina, A., Ikari, Y., Iino, M., Yamaguchi, T., Kuribayashi, S.

    International Journal of Cardiovascular Imaging　29　(1 SUPPL.)　2013年

    DOI： 10.1007/s10554-013-0253-3 　

    ISSN：1569-5794 1573-0743

  15. Dose-Finding study of landiolol hydrochloride: A short-acting Β1-Blocker for controlling heart rate during coronary computed-Tomography angiography in japan

    Hirano, M., Hara, K., Ikari, Y., Jinzaki, M., Iino, M., Hamada, C., Kuribayashi, S.

    Advances in Therapy　30　(9)　2013年

    DOI： 10.1007/s12325-013-0053-0 　

    ISSN：0741-238X 1865-8652

  16. Three-dimensional T2-weighted imaging using the dark blood method for detecting pulmonary embolisms: Comparison with computed tomography angiography

    Ishiyama, M., Matsusako, M., Oikado, K., Nishi, Y., Ohi, K., Hirano, M., Saida, Y.

    Japanese Journal of Radiology　29　(9)　2011年

    DOI： 10.1007/s11604-011-0609-3 　

    ISSN：1867-1071 1867-108X

  17. Severe vasospastic angina with ventricular fibrillation suggested by iodine-123 beta-methyl-p-iodophenyl-pentadecanoic acid in a young woman

    Ohtaki, Y., Chikamori, T., Tanaka, H., Igarashi, Y., Hirano, M., Yamada, M., Hida, S., Yamashina, A.

    Annals of Nuclear Medicine　25　(1)　2011年

    DOI： 10.1007/s12149-010-0423-5 　

    ISSN：0914-7187

  18. [Noninvasive diagnostic imaging technique for arteriosclerotic lesion].

    Yamada, M., Hirano, M., Yoshida, M., Yamashina, A.

    Nippon rinsho. Japanese journal of clinical medicine　69　(1)　2011年

    ISSN：0047-1852

  19. Cardiac cell damage in hypertrophic cardiomyopathy evaluated by beta-methylbranched fatty acid analogue, iodine-123-15-(p-iodophenyl)-3-(R,S)- methylpentadecanoic acid (BMIPP) myocardial fatty-acid imaging and late gadolinium-enhanced contrast magnetic resonance imaging: Usefulness of combining the two techniques

    Kawade, M., Teraoka, K., Hirano, M., Igarashi, Y., Yamada, M., Chikamori, T., Takazawa, K., Yamashina, A.

    Journal of Tokyo Medical University　69　(1)　2011年

    ISSN：0040-8905

  20. [Bone and calcium update; diagnosis and therapy of bone metabolism disease update. Clinical assessment of atherosclerosis in aorta].

    Shiina, K., Tomiyama, H., Yamada, M., Hirano, M., Yoshida, M., Yamashina, A.

    Clinical calcium　21　(12)　2011年

    ISSN：0917-5857

  21. Cardiac magnetic resonance imaging abnormalities in patients with systemic lupus erythematosus: A preliminary report

    Kobayashi, H., Giles, J.T., Arinuma, Y., Yokoe, I., Hirano, M., Kobayashi, Y.

    Modern Rheumatology　20　(3)　2010年

    DOI： 10.1007/s10165-009-0268-8 　

    ISSN：1439-7609 1439-7595

  22. Assessment of myocardial abnormalities in rheumatoid arthritis using a comprehensive cardiac magnetic resonance approach: A pilot study

    Kobayashi, Y., Giles, J.T., Hirano, M., Yokoe, I., Nakajima, Y., Bathon, J.M., Lima, J.A.C., Kobayashi, H.

    Arthritis Research and Therapy　12　(5)　2010年

    DOI： 10.1186/ar3131 　

    ISSN：1478-6354 1478-6362

  23. Cardiac magnetic resonance imaging with pharmacological stress perfusion and delayed enhancement in asymptomatic patients with systemic sclerosis

    Kobayashi, H., Yokoe, I., Hirano, M., Nakamura, T., Nakajima, Y., Fontaine, K.R., Giles, J.T., Kobayashi, Y.

    Journal of Rheumatology　36　(1)　2009年

    DOI： 10.3899/jrheum.080377 　

    ISSN：0315-162X

  24. Frequency and distribution of late gadolinium enhancement in magnetic resonance imaging of patients with apical hypertrophic cardiomyopathy and patients with asymmetrical hypertrophic cardiomyopathy: A comparative study

    Yamada, M., Teraoka, K., Kawade, M., Hirano, M., Yamashina, A.

    International Journal of Cardiovascular Imaging　25　(SUPPL. 1)　2009年

    DOI： 10.1007/s10554-008-9406-1 　

    ISSN：1569-5794

  25. Diagnostic accuracy of stress myocardial perfusion MRI and late gadolinium-enhanced MRI for detecting flow-limiting coronary artery disease: A multicenter study

    Kitagawa, K., Sakuma, H., Nagata, M., Okuda, S., Hirano, M., Tanimoto, A., Matsusako, M., Lima, J.A.C., Kuribayashi, S., Takeda, K.

    European Radiology　18　(12)　2008年

    DOI： 10.1007/s00330-008-1097-4 　

    ISSN：0938-7994

  26. Feasiblity study of multidetector-row computed tomography (MDCT) for detection of the optimum coronary venous system in cardiac resynchronization therapy

    Ono, H., Hirano, M., Goseki, Y., Morisaki, M., Kawade, M., Yamada, M., Ishiyama, T., Kobayashi, H., Teraoka, K., Yamashina, A.

    Journal of Tokyo Medical University　64　(2)　2006年

    ISSN：0040-8905

  27. Delayed contrast enhancement in a patient with perimyocarditis on contrast-enhanced cardiac MRI: Case report

    Teraoka, K., Hirano, M., Yannbe, M., Ohtaki, Y., Abe, T.O., Yamashina, A.

    International Journal of Cardiovascular Imaging　21　(2-3)　2005年

    DOI： 10.1007/s10554-004-4016-z 　

    ISSN：1569-5794

  28. Images in cardiovascular medicine. No delayed enhancement on contrast magnetic resonance imaging with Takotsubo cardiomyopathy.

    Teraoka, K., Kiuchi, S., Takada, N., Hirano, M., Yamashina, A.

    Circulation　111　(16)　2005年

    ISSN：1524-4539

  29. Erratum: Delayed contrast enhancement of MRI in hypertrophic cardiomyopathy (Magnetic Resonance Imaging (2004) 22 (155-161))

    Teraoka, K., Hirano, M., Ookubo, H., Sasaki, K., Katsuyama, H., Amino, M., Abe, Y., Yamashina, A.

    Magnetic Resonance Imaging　22　(6)　901-901　2004年

    DOI： 10.1016/j.mri.2004.05.001 　

    ISSN：0730-725X

  30. Delayed contrast enhancement of MRI in hypertrophic cardiomyopathy

    Teraoka, K., Hirano, M., Ookubo, H., Sasaki, K., Katsuyama, H., Amino, M., Abe, Y., Yamashina, A.

    Magnetic Resonance Imaging　22　(2)　2004年

    DOI： 10.1016/j.mri.2003.08.009 　

    ISSN：0730-725X

  31. Kawasaki disease-associated coronary artery lesions with navigator echo-based - Respiratory-gated three dimensional coronary magnetic resonance angiography compared with echocardiography in young children

    Amino, M., Teraoka, K., Ookuboa, Y., Hirano, M., Sasaki, K., Katuyama, H., Kawashima, N., Kakizaki, D.

    Journal of Tokyo Medical University　62　(2)　2004年

    ISSN：0040-8905

  32. Assessment of the time course of stunned myocardium with cardiac magnetic resonance imaging: A case report

    Kiuchi, S., Teraoka, K., Hirano, M., Niwayama, M., Takahashi, E., Morishima, T., Uchiyama, T., Nagai, Y., Yamashina, A.

    Journal of Cardiology　44　(2)　2004年

    ISSN：0914-5087

  33. Hypertrophic cardiomyopathy with mid-ventricular obstruction complicated by apical aneurysm appearing as delayed contrast hyperenhancement on magnetic resonance imaging: Two case reports

    Teraoka, K., Hirano, M., Ogawa, T., Sasame, A., Yanagisawa, H., Namatame, Y., Shindo, N., Takei, Y., Sasaki, K., Katsuyama, H., Abe, K., Yamashina, A.

    Journal of Cardiology　42　(2)　2003年

    ISSN：0914-5087

  34. A 65-year-old man complaining of shortness of breath after open heart surgery

    Teraoka, K., Hirano, M., Tanaka, N., Akata, S., Yamashina, A.

    Journal of Cardiology　41　(5)　2003年

    ISSN：0914-5087

  35. A young man with frequent ventricular tachycardia

    Teraoka, K., Hirano, M., Ookubo, T., Abe, K., Yamashina, A.

    Journal of Cardiology　39　(4)　2002年

    ISSN：0914-5087

  36. Clinical study on the Adriamycin induced cardiomyopathy using the cardiac magnetic resonance imaging - Total dose and cardiac dysfunction

    Yamaguchi, K., Teraoka, K., Hirano, M.

    Journal of Tokyo Medical University　59　(3)　2001年

    ISSN：0040-8905

  37. Progressive cardiac dysfunction in adriamycin-induced cardiomyopathy rats

    Teraoka, K., Hirano, M., Yamaguchi, K., Yamashina, A.

    European Journal of Heart Failure　2　(4)　2000年

    DOI： 10.1016/S1388-9842(00)00111-2 　

    ISSN：1388-9842

  38. Erratum: Carvedilol improved the mortality and the reduction in cardiac function in rat models of adriamycin-induced cardiomyopathy (Journal of Cardiac Failure (1999) 5:1 (59))

    Hirano, M., Yamaguchi, K., Yamashina, A.

    Journal of Cardiac Failure　5　(4)　386-386　1999年

    ISSN：1071-9164

  39. Percent wall thickness evaluated by Gd-DTPA enhanced cine MRI as an indicator of local parietal movement in hypertrophic cardiomyopathy

    Hirano, M.

    Journal of Tokyo Medical University　56　(6)　1998年

    ISSN：0040-8905

︎全件表示 ︎最初の5件までを表示

MISC 1

  1. FIESTA法による負荷心筋パーフュージョンMRIの有意冠動脈狭窄診断能 多施設共同研究

    北川 覚也, 佐久間 肇, 奥田 茂男, 谷本 伸弘, 松迫 正樹, 平野 雅春, 野崎 敦

    日独医報　50　(3)　584-584　2005年9月

    出版者・発行元： バイエル薬品(株)

    ISSN： 0912-0351