研究者詳細

顔写真

フアン　ツー　チン
Huang Tzu Ting
Huang Tzu Ting
所属
大学院生命科学研究科　脳生命統御科学専攻　神経ネットワーク講座（神経行動分野）
職名
助教
学位

  • 博士（理学）（名古屋大学）

  • Ｍ．Ｓ．（National Taiwan University）

e-Rad 研究者番号
00909848

所属学協会 2

  • Genetics Society of America

  • 日本神経科学学会

論文 6

  1. Analyses of Genetic Regulation of the Nervous System in the Nematode Caenorhabditis elegans 国際誌

    Tzu-Ting Huang, Ikue Mori

    Methods in Molecular Biology　2024年4月18日

    DOI： 10.1007/978-1-0716-3810-1_26 　

    ISSN：1064-3745 1940-6029

  2. Analyses of Neural Circuits Governing Behavioral Plasticity in the Nematode Caenorhabditis elegans 国際誌

    Tzu-Ting Huang, Ikue Mori

    Methods in Molecular Biology　2024年4月18日

    DOI： 10.1007/978-1-0716-3810-1_27 　

    ISSN：1064-3745 1940-6029

  3. Age‐dependent changes in response property and morphology of a thermosensory neuron and thermotaxis behavior in Caenorhabditis elegans

    Tzu-Ting Huang, Hironori J. Matsuyama, Yuki Tsukada, Aakanksha Singhvi, Ru-Ting Syu, Yun Lu, Shai Shaham, Ikue Mori, Chun-Liang Pan

    Aging Cell　19　(5)　2020年4月

    出版者・発行元： Wiley

    DOI： 10.1111/acel.13146 　

    ISSN：1474-9718 1474-9726

  4. Longevity control by the nervous system: Sensory perception, stress response and beyond

    Chih-Ta Lin, Chun-Wei He, Tzu-Ting Huang, Chun-Liang Pan

    Translational Medicine of Aging　1　41-51　2017年10月

    出版者・発行元： Elsevier {BV}

    DOI： 10.1016/j.tma.2017.07.001 　

    ISSN：2468-5011

  5. A C. elegans Thermosensory Circuit Regulates Longevity through crh-1 /CREB-Dependent flp-6 Neuropeptide Signaling

    Yen-Chih Chen, Hung-Jhen Chen, Wei-Chin Tseng, Jiun-Min Hsu, Tzu-Ting Huang, Chun-Hao Chen, Chun-Liang Pan

    Developmental Cell　39　(2)　209-223　2016年10月

    出版者・発行元： Elsevier {BV}

    DOI： 10.1016/j.devcel.2016.08.021 　

    ISSN：1534-5807

  6. Injection of Human Cord Blood Cells With Hyaluronan Improves Postinfarction Cardiac Repair in Pigs

    Ming-Yao Chang, Tzu-Ting Huang, Chien-Hsi Chen, Bill Cheng, Shiaw-Min Hwang, Patrick C.H. Hsieh

    Stem Cells Translational Medicine　5　(1)　56-66　2016年1月

    出版者・発行元： Oxford University Press ({OUP})

    DOI： 10.5966/sctm.2015-0092 　

    ISSN：2157-6564 2157-6580

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    <jats:title>Abstract</jats:title> <jats:sec> <jats:title /> <jats:p>Recent clinical trials using autologous bone marrow or peripheral blood cells to treat myocardial infarction (MI) show controversial results, although the treatment has a good safety profile. These discrepancies are likely caused by factors such as aging, systemic inflammation, and cell processing procedures, all of which might impair the regenerative capability of the cells used. Here, we tested whether injection of human cord blood mononuclear cells (CB-MNCs) combined with hyaluronan (HA) hydrogel improves cell therapy efficacy in a pig MI model. A total of 34 minipigs were divided into 5 groups: sham operation (Sham), surgically induced-MI plus injection with normal saline (MI+NS), HA only (MI+HA), CB-MNC only (MI+CB-MNC), or CB-MNC combined with HA (MI+CB-MNC/HA). Two months after the surgery, injection of MI+CB-MNC/HA showed the highest left ventricle ejection fraction (51.32% ± 0.81%) compared with MI+NS (42.87% ± 0.97%, p &amp;lt; .001), MI+HA (44.2% ± 0.63%, p &amp;lt; .001), and MI+CB-MNC (46.17% ± 0.39%, p &amp;lt; .001) groups. The hemodynamics data showed that MI+CB-MNC/HA improved the systolic function (+dp/dt) and diastolic function (−dp/dt) as opposed to the other experimental groups, of which the CB-MNC alone group only modestly improved the systolic function (+dp/dt). In addition, CB-MNC alone or combined with HA injection significantly decreased the scar area and promoted angiogenesis in the infarcted region. Together, these results indicate that combined CB-MNC and HA treatment improves heart performance and may be a promising treatment for ischemic heart diseases.</jats:p> </jats:sec> <jats:sec> <jats:title>Significance</jats:title> <jats:p>This study using healthy human cord blood mononuclear cells (CB-MNCs) to treat myocardial infarction provides preclinical evidence that combined injection of hyaluronan and human CB-MNCs after myocardial infarction significantly increases cell retention in the peri-infarct area, improves cardiac performance, and prevents cardiac remodeling. Moreover, using healthy cells to replace dysfunctional autologous cells may constitute a better strategy to achieve heart repair and regeneration.</jats:p> </jats:sec>

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共同研究・競争的資金等の研究課題 2

  1. Neural mechanisms of long-term nutritive memory by the neuroendocrine system and dopamine neurons

    提供機関：Japan Society for the Promotion of Science

    制度名：Grants-in-Aid for Scientific Research

    研究種目：Grant-in-Aid for Early-Career Scientists

    研究機関：Tohoku University

    2025年4月 ～ 2028年3月

  2. Genetic and circuit control of decision-making and action-planning in associative learning

    Huang Tzu Ting

    提供機関：Japan Society for the Promotion of Science

    制度名：Grants-in-Aid for Scientific Research

    研究種目：Grant-in-Aid for Research Activity Start-up

    研究機関：Nagoya University

    2021年8月 ～ 2023年3月

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    How do animals select among various behavioral and environmental alternatives based on behavioral goals and experiences? From a screen for mutants defective in maintaining isothermal tracking behavior, we found mutants carrying null mutations in the G-protein coupled receptor kinase gene failed to maintain isothermal tracks at the cultivation temperature. grk-1 expresses broadly in the nervous systems, including the thermosensory neurons AFD, AWC, the interneurons AIY, and RIA. However, simultaneously expressing grk-1 in AFD, AWC, AIY, and RIA was insufficient to restore the isothermal tracking defect in the grk-1 null mutant. Subsequent analyses identify a glutamatergic interneuron is partially involved in maintaining isothermal tracking through grk-1 signaling. Our study provides genetic insights into the precise sensorimotor computation of goal-driven behaviors in a dynamic environment.