Bronchiectasis in Japanese patients with chronic obstructive pulmonary disease: A prospective cohort study. 国際誌

Seiichi Kobayashi, Mitsuhiro Yamada, Masatsugu Ishida, Manabu Ono, Hikari Satoh, Masakazu Hanagama, Masaru Yanai

Respiratory investigation　63　(5)　942-948　2025年9月

DOI： 10.1016/j.resinv.2025.07.016 　

A real-world clustering analysis reveals heterogeneous response patterns to biologic therapy in severe asthma

Shuichiro Matsumoto, Yosuke Kamide, Naoya Fujino, Mitsuhiro Yamada, Yoshinao Ono, Seiichi Kobayashi, Teruyuki Sato, Kiyoshi Sekiya, Takuto Endo, Tsutomu Tamada, Tomohiro Ichikawa, Hiroyuki Aizawa, Hirohito Sano, Yorihiko Kyogoku, Takuya Saito, Shuichi Konno, Manami Suzuki, Koji Okutomo, Masami Taniguchi, Hisatoshi Sugiura

Exploration of Asthma & Allergy　3　2025年8月18日

DOI： 10.37349/eaa.2025.100990 　

eISSN：2837-5076

Supersulfide controls intestinal inflammation by suppressing CD4+ T cell proliferation

Shunichi Tayama, Yuya Kitamura, Kyoga Hiraide, Hibiki Suzuki, Jing Li, Ziying Yang, Ryoji Mitsuwaka, Akihisa Kawajiri, Kosuke Sato, Feng Gao, Taku Nakai, Yuko Okuyama, Tadahisa Numakura, Mitsuhiro Yamada, Tomoaki Ida, Masanobu Morita, Takeshi Kawabe, Takaaki Akaike, Naoto Ishii

Frontiers in Immunology　16　2025年4月15日

DOI： 10.3389/fimmu.2025.1506580 　

eISSN：1664-3224

Histological and genetic features and therapeutic responses of lung cancers explored via the global analysis of their metabolome profile. 国際誌

Daisuke Narita, Eiji Hishinuma, Risa Ebina-Shibuya, Eisaku Miyauchi, Naomi Matsukawa, Ikuko N Motoike, Kengo Kinoshita, Seizo Koshiba, Yoko Tsukita, Hirotsugu Notsuda, Nozomu Kimura, Ryota Saito, Koji Murakami, Naoya Fujino, Tomohiro Ichikawa, Mitsuhiro Yamada, Tsutomu Tamada, Hisatoshi Sugiura

Lung cancer (Amsterdam, Netherlands)　200　108082-108082　2025年1月8日

DOI： 10.1016/j.lungcan.2025.108082 　

Blood DNA virome associates with autoimmune diseases and COVID-19

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Nature Genetics　57　(1)　2025年

DOI： 10.1038/s41588-024-02022-z 　

ISSN：1061-4036 1546-1718

Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Bhak, Y., Raptis, V., He, Y., Nakanishi, T., Macdonald-Dunlop, E., Sagiya, Y., Morisaki, T., Matsuda, K., Okada, Y., Fukunaga, K., Kanai, T., Ogawa, S., Miyano, S., Imoto, S., Kimura, A., Kitagawa, Y., Koike, R., Ishii, M., Tokunaga, K., Hasegawa, N., Sato, T., Kumanogoh, A., Fukui, Y., Ai, M., Katayama, K., Ueno, T., Nannya, Y., Omae, Y., Egi, M., Makino, S., Hirouchi, T., Oshio, T., Nakano, C., Kodaka, N., Matsuse, H., Watanabe, H., Seike, M., Saito, Y., Fujita, K., Kashiwada, T., Tanaka, T., Ono, A., Utsugi, M., Ishii, T., Tominaga, Y., Kamimaki, I., Kuramochi, M., Takahashi, M., Hayashi, S., Maeno, T., Yatomi, M., Yamashita, T., Imamura, T., Kanai, M., Kishi, H., Fujii, K., Takahashi, H., Iwagoe, H., Shinoki, M., Hashino, T., Yamada, Y., Sato, Y., Minemura, H., Nikaido, T., Tanino, Y., Shibata, Y., Kimura, T., Ohta, S., Tanaka, A., Sagara, H., Sato, M., Igarashi, A., Inoue, S., Watanabe, M., Ohira, Y., Endo, M., Shimada, H., Miyagawa, K., Umeda, A., Motegi, M., Ooshima, N., Nagai, 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Scientific Reports　15　(1)　2025年

DOI： 10.1038/s41598-025-10031-z 　

ISSN：2045-2322

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

Edahiro, R., Sato, G., Naito, T., Shirai, Y., Saiki, R., Sonehara, K., Tomofuji, Y., Yamamoto, K., Namba, S., Sasa, N., Nagao, G., Wang, Q.S., Takahashi, Y., Hasegawa, T., Kishikawa, T., Suzuki, K., Liu, Y.-C., Motooka, D., Takuwa, A., Tanaka, H., Azekawa, S., Okada, Y., Kanai, T., Ogawa, S., Kitagawa, Y., Ishii, M., Tokunaga, K., Hasegawa, N., Sato, T., Kumanogoh, A., Ai, M., Katayama, K., Takano, T., Ueno, T., Nannya, Y., Omae, Y., Egi, M., Makino, S., Hirouchi, T., Oshio, T., Nakano, C., Kodaka, N., Matsuse, H., Watanabe, H., Seike, M., Saito, Y., Fujita, K., Kashiwada, T., Tanaka, T., Ono, A., Utsugi, M., Ishii, T., Tominaga, Y., Kamimaki, I., Kuramochi, M., Takahashi, M., Hayashi, S., Maeno, T., Yatomi, M., Yamashita, T., Imamura, T., Kanai, M., Kishi, H., Fujii, K., Takahashi, H., Iwagoe, H., Shinoki, M., Hashino, T., Yamada, Y., Sato, Y., Minemura, H., Nikaido, T., Tanino, Y., Shibata, Y., Kimura, T., Ohta, S., Tanaka, A., Sagara, H., Sato, M., Igarashi, A., Inoue, S., Watanabe, 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Nature Genetics　57　(8)　2025年

DOI： 10.1038/s41588-025-02266-3 　

ISSN：1061-4036 1546-1718

Human Lung Cell Separation Strategies for Translational Research

Naoya Fujino, Mitsuhiro Yamada, Takuya Saito, Shuichi Konno, Hisatoshi Sugiura

American Journal of Respiratory Cell and Molecular Biology　71　(5)　621-622　2024年11月

DOI： 10.1165/rcmb.2024-0338LE 　

ISSN：1044-1549

eISSN：1535-4989

Characterization of IL-6R-expressing monocytes in the lung of patients with chronic obstructive pulmonary disease. 国際誌

Yoshinao Ono, Naoya Fujino, Takuya Saito, Shuichiro Matsumoto, Shuichi Konno, Takuto Endo, Manami Suzuki, Mitsuhiro Yamada, Yoshinori Okada, Hisatoshi Sugiura

Respiratory investigation　62　(5)　856-866　2024年9月

DOI： 10.1016/j.resinv.2024.07.013 　

Endothelium-Derived Extracellular Vesicles Expressing Intercellular Adhesion Molecules Reflect Endothelial Permeability and Sepsis Severity. 国際誌

Yusuke Takei, Mitsuhiro Yamada, Koji Saito, Yoshinobu Kameyama, Takanori Aihara, Yudai Iwasaki, Toru Murakami, Yu Kaiho, Akira Ohkoshi, Daisuke Konno, Takuya Shiga, Kazuhiro Takahashi, Saori Ikumi, Hiroaki Toyama, Yutaka Ejima, Masanori Yamauchi

Anesthesia and analgesia　139　(2)　385-396　2024年8月1日

DOI： 10.1213/ANE.0000000000006988 　

Fractional exhaled nitric oxide distribution and its relevant factors in the general adult population and its healthy subpopulation. 国際誌

Mitsuhiro Yamada, Masato Takase, Kumi Nakaya, Tomohiro Nakamura, Mana Kogure, Naoki Nakaya, Naoya Fujino, Tsutomu Tamada, Chikashi Iwasaki, Manami Suzuki, Shuichiro Matsumoto, Nobuo Fuse, Akira Uruno, Kazuki Kumada, Soichi Ogishima, Shinichi Kuriyama, Masakazu Ichinose, Hisatoshi Sugiura, Atsushi Hozawa

The journal of allergy and clinical immunology. Global　3　(3)　100253-100253　2024年8月

DOI： 10.1016/j.jacig.2024.100253 　

Identification of Siglec-1-negative alveolar macrophages with proinflammatory phenotypes in chronic obstructive pulmonary disease. 国際誌

Takuya Saito, Naoya Fujino, Yorihiko Kyogoku, Mitsuhiro Yamada, Koji Okutomo, Yoshinao Ono, Shuichi Konno, Takuto Endo, Koji Itakura, Shuichiro Matsumoto, Hirohito Sano, Hiroyuki Aizawa, Tadahisa Numakura, Katsuhiro Onodera, Yoshinori Okada, Tracy Hussell, Masakazu Ichinose, Hisatoshi Sugiura

American journal of physiology. Lung cellular and molecular physiology　326　(6)　L672-L686　2024年6月1日

DOI： 10.1152/ajplung.00303.2023 　

Glutathione supersulphide regulates T-cell receptor signalling

Yusaku Sasaki, Tadahisa Numakura, Mitsuhiro Yamada, Hisatoshi Sugiura, Tetsuro Matsunaga, Tomoaki Ida, Masanobu Morita, Ayumi Suzuki, Shuichiro Matsumoto, Madoka Kawaguchi, Takeshi Kawabe, Shunichi Tayama, Yuko Okuyama, Tsuyoshi Takata, Kenji Inaba, Satoshi Watanabe, Manami Suzuki, Hirohito Sano, Yorihiko Kyogoku, Rie Tanaka, Ayumi Mitsune, Tomohiro Ichikawa, Naoya Fujino, Tsutomu Tamada, Naoto Ishii, Masakazu Ichinose, Takaaki Akaike, Hozumi Motohashi

2024年5月2日

DOI： 10.1101/2024.04.30.591985 　

Peripheral blood biomarkers associated with combination of immune checkpoint blockade plus chemotherapy in NSCLC. 国際誌

Nozomu Kimura, Yoko Tsukita, Risa Ebina-Shibuya, Eisaku Miyauchi, Mitsuhiro Yamada, Daisuke Narita, Ryota Saito, Chihiro Inoue, Naoya Fujino, Tomohiro Ichikawa, Tsutomu Tamada, Hisatoshi Sugiura

Cancer biomarkers : section A of Disease markers　2024年3月20日

DOI： 10.3233/CBM-230301 　

Acquisition of Amikacin Resistance during Amikacin Liposome Inhalation Suspension Add-on Therapy for Mycobacterium avium Complex-Pulmonary Disease. 国際誌

Hirohito Sano, Naoya Fujino, Tadahisa Numakura, Mitsuhiro Yamada, Naoki Tode, Hisatoshi Sugiura

Annals of the American Thoracic Society　2024年1月29日

DOI： 10.1513/AnnalsATS.202305-454RL 　

Treatment with systemic corticosteroid versus placebo for exacerbations of COPD: A systematic review and meta-analysis: Meta-analysis of systemic corticosteroid treatment for COPD exacerbations

Koarai, A., Yamada, M., Ichikawa, T., Fujino, N., Sugiura, H.

Respiratory Investigation　62　(3)　2024年

DOI： 10.1016/j.resinv.2024.03.009 　

ISSN：2212-5345 2212-5353

The dorsal muscle group area at the T12 vertebral level as a risk factor for tolerability of nintedanib in patients with idiopathic pulmonary fibrosis or other progressive fibrosing interstitial lung diseases

Ono, M., Kobayashi, S., Masakazu, H., Ishida, M., Sato, H., Okutomo, K., Shirai, Y., Takahashi, K., Yamada, M., Fujino, N., Yamanda, S., Yanai, M.

Medicine United States　103　(28)　2024年

DOI： 10.1097/MD.0000000000038920 　

ISSN：0025-7974 1536-5964

Gastrointestinal symptoms in COVID-19 and disease severity: a Japanese registry-based retrospective cohort study

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Journal of Gastroenterology　59　(3)　2024年

DOI： 10.1007/s00535-023-02071-x 　

ISSN：0944-1174 1435-5922

CYP27A1-27-hydroxycholesterol axis in the respiratory system contributes to house dust mite-induced allergic airway inflammation. 国際誌

Tatsunori Ito, Tomohiro Ichikawa, Mitsuhiro Yamada, Yuichiro Hashimoto, Naoya Fujino, Tadahisa Numakura, Yusaku Sasaki, Ayumi Suzuki, Katsuya Takita, Hirohito Sano, Yorihiko Kyogoku, Takuya Saito, Akira Koarai, Tsutomu Tamada, Hisatoshi Sugiura

Allergology international : official journal of the Japanese Society of Allergology　2023年8月20日

DOI： 10.1016/j.alit.2023.08.005 　

Supersulphides provide airway protection in viral and chronic lung diseases. 国際誌 査読有り

Tetsuro Matsunaga, Hirohito Sano, Katsuya Takita, Masanobu Morita, Shun Yamanaka, Tomohiro Ichikawa, Tadahisa Numakura, Tomoaki Ida, Minkyung Jung, Seiryo Ogata, Sunghyeon Yoon, Naoya Fujino, Yorihiko Kyogoku, Yusaku Sasaki, Akira Koarai, Tsutomu Tamada, Atsuhiko Toyama, Takakazu Nakabayashi, Lisa Kageyama, Shigeru Kyuwa, Kenji Inaba, Satoshi Watanabe, Péter Nagy, Tomohiro Sawa, Hiroyuki Oshiumi, Masakazu Ichinose, Mitsuhiro Yamada, Hisatoshi Sugiura, Fan-Yan Wei, Hozumi Motohashi, Takaaki Akaike

Nature communications　14　(1)　4476-4476　2023年7月25日

DOI： 10.1038/s41467-023-40182-4 　

Associations between birth weight and lung function in a Japanese adult population: The tohoku medical megabank community-based cohort study. 国際誌

Takashi Ohe, Mitsuhiro Yamada, Atsushi Hozawa, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Nobuo Fuse, Shinichi Kuriyama, Ayumi Mitsune, Ayumi Suzuki, Shuichiro Matsumoto, Tetsuya Hatakeyama, Chikashi Iwasaki, Manami Suzuki, Naoya Fujino, Tadahisa Numakura, Tomohiro Ichikawa, Akira Koarai, Tsutomu Tamada, Masayuki Yamamoto, Masakazu Ichinose, Hisatoshi Sugiura

Respiratory investigation　61　(5)　588-600　2023年7月8日

DOI： 10.1016/j.resinv.2023.06.004 　

Circulating Extracellular Vesicle Levels in Patients with Coronavirus Disease 2019 Coagulopathy: A Prospective Cohort Study. 国際誌

Yudai Iwasaki, Yusuke Takei, Mitsuhiro Yamada, Shigekazu Sugino, Koji Saito, Tetsuji Aoyagi, Kengo Oshima, Hajime Kanamori, Hiroaki Baba, Kentarou Takei, Koichi Tokuda, Eichi N Kodama, Tetsuro Kamo, Tadashi Kamio, Takehiko Kasai, Satoru Ogawa, Masanori Yamauchi

Journal of clinical medicine　12　(10)　2023年5月14日

DOI： 10.3390/jcm12103460 　

Combined fat mass and fat-free mass indices and lung function among Japanese population: The Tohoku Medical Megabank Community-based Cohort Study.

Masato Takase, Mitsuhiro Yamada, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

Journal of epidemiology　2023年4月8日

DOI： 10.2188/jea.JE20220355 　

Real-world efficacy of anti-IL-5 treatment in patients with allergic bronchopulmonary aspergillosis. 国際誌

Katsuyoshi Tomomatsu, Hirotaka Yasuba, Takashi Ishiguro, Shiro Imokawa, Johsuke Hara, Seiko Soeda, Norihiro Harada, Naomi Tsurikisawa, Naohiro Oda, Shigeki Katoh, Takanori Numata, Yasuteru Sugino, Mitsuhiro Yamada, Mitsuhiro Kamimura, Takeshi Terashima, Naoki Okada, Jun Tanaka, Tsuyoshi Oguma, Koichiro Asano

Scientific reports　13　(1)　5468-5468　2023年4月4日

DOI： 10.1038/s41598-023-32246-8 　

Association between lung function and hypertension and home hypertension in a Japanese population: the Tohoku Medical Megabank Community-Based Cohort Study. 国際誌 査読有り

Masato Takase, Mitsuhiro Yamada, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

Journal of hypertension　41　(3)　443-52　2023年1月4日

DOI： 10.1097/HJH.0000000000003356 　

A second update on mapping the human genetic architecture of COVID-19

Kanai, M., Andrews, S.J., Cordioli, M., Stevens, C., Neale, B.M., Daly, M., Ganna, A., Pathak, G.A., Iwasaki, A., Karjalainen, J., Mehtonen, J., Pirinen, M., Chwialkowska, K., Trankiem, A., Balaconis, M.K., Veerapen, K., Wolford, B.N., Ahmad, H.F., Andrews, S., von Hohenstaufen, Puoti, K.A., Boer, C., Boua, P.R., Butler-Laporte, G., Cadilla, C.L., Chwialkowska, K., Colombo, F., Douillard, V., Dueker, N., Dutta, A.K., El-Sherbiny, Y.M., Eltoukhy, M.M., Esmaeeli, S., Faucon, A., Fave, M.-J., Cadenas, I.F., Francescatto, M., Francioli, L., Franke, L., Fuentes, M., Dur{\'a}n, R.G., Cabrero, D.G., Harry, E.N., Jansen, P., Szentp{\'e}teri, J.L., Kaja, E., Kanai, M., Kirk, C., Kousathanas, A., Krieger, J.E., Patel, S.K., Lema?on, A., Limou, S., Li{\'o}, P., Marouli, E., Marttila, M.M., Medina-G{\'o}mez, C., Michaeli, Y., Migeotte, I., Mondal, S., Moreno-Estrada, A., Moya, L., Nakanishi, T., Nasir, J., Pasko, D., Pearson, N.M., Pereira, A.C., Priest, J., Prijatelj, V., Prokic, I., Teumer, A., V{\'a}rnai, R., Romero-G{\'o}mez, M., Roos, C., Rosenfeld, J., Ruolin, L., Schulte, E.C., Schurmann, C., Sedaghati-khayat, B., Shaheen, D., Shivanathan, I., Sipeky, C., Sirui, Z., Striano, P., Tanigawa, Y., Remesal, A.U., Vadgama, N., Vallerga, C.L., van der Laan, S., Verdugo, R.A., Wang, Q.S., Wei, Z., Zainulabid, U.A., Z{\'a}rate, R.N., Auton, A., Shelton, J.F., Shastri, A.J., Weldon, C.H., Filshtein-Sonmez, T., Coker, D., Symons, A., Aslibekyan, S., O?Connell, J., Ye, C., Hatoum, A.S., Agrawal, A., Bogdan, R., Colbert, S.M.C., Thompson, W.K., Fan, C.C., Johnson, E.C., Niazyan, L., Davidyants, M., Arakelyan, A., Avetyan, D., Bekbossynova, M., Tauekelova, A., Tuleutayev, M., Sailybayeva, A., Ramankulov, Y., Zholdybayeva, E., Dzharmukhanov, J., Kassymbek, K., Tsechoeva, T., Turebayeva, G., Smagulova, Z., Muratov, T., Khamitov, S., Kwong, A.S.F., Timpson, N.J., Niemi, M.E.K., Rahmouni, S., Guntz, J., Beguin, Y., Cordioli, M., Pigazzini, S., Nkambule, L., Georges, M., Moutschen, M., Misset, B., Darcis, G., Gofflot, S., Bouysran, Y., Busson, A., Peyrassol, X., Wilkin, F., Pichon, B., Smits, G., Vandernoot, I., Goffard, J.-C., Tiembe, N., Morrison, D.R., Afilalo, J., Mooser, V., Richards, J.B., Rousseau, S., Durand, M., Butler-Laporte, G., Forgetta, V., Laurent, L., Afrasiabi, Z., Bouab, M., Tselios, C., Xue, X., Afilalo, M., Oliveira, M., St-Cyr, J., Boisclair, A., Ragoussis, J., Auld, D., Kaufmann, D.E., Lathrop, G.M., Bourque, G., D{\'e}cary, S., Falcone, E.L., Montpetit, A., Pich{\'e}, A., Renoux, C., Tremblay, K., Tse, S.M., Zawati, M.H., Davis, L.K., Cox, N.J., Below, J.E., Sealock, J.M., Faucon, A.B., Shuey, M.M., Polikowsky, H.G., Petty, L.E., Shaw, D.M., Chen, H.-H., Zhu, W., Schmidt, A., Ludwig, K., Maj, C., Rolker, S., Balla, D., Behzad, P., N{\"o}then, M.M., Fazaal, J., Keitel, V., Keitel, V., Jensen, B.-E.O., Feldt, T., Marx, N., Dreher, M., Pink, I., Cornberg, M., Illig, T., Lehmann, C., Schommers, P., Rybniker, J., Augustin, M., Knopp, L., Kurth, I., Eggermann, T., Volland, S., Berger, M.M., Brenner, T., Hinney, A., Witzke, O., Konik, M.J., Bals, R., Herr, C., Ludwig, N., Walter, J., Latz, E., Schmidt, S.V., Brooks, J.D., Bull, S., Elliott, L.T., Gagnon, F., Greenwood, C.M.T., Hung, R.J., Lawless, J.F., Paterson, A.D., Sun, L., Rauh, M., Briollais, L., Gingras, A.-C., Bombard, Y., Pugh, T.J., Simpson, J., Goneau, L.W., Halevy, A.R., Maslove, D.M., Borgundvaag, B., Devine, L., Bearss, E., Richardson, D., Arnoldo, S., Friedman, S.M., Taher, A., Stern, S., Dagher, M., Vasilevska-Ristovska, J., Biggs, C.M., Mickiewicz, B., Strug, L.J., Scherer, S.W., Aziz, N., Jones, S.J.M., Knoppers, B.M., Lathrop, M., Turvey, S.E., Yeung, R.S.M., Allen, U., Cheung, A.M., Herridge, M.S., Hunt, M., Lerner-Ellis, J., Taher, J., Parekh, R.S., Hiraki, L.T., Cowan, J., Ducharme, F.M., Ostrowski, M., Bernier, F.P., Kellner, J., Garg, E., Yoo, S., Vlasschaert, C., Frangione, E., Chung, M., Noor, A., Greenfeld, E., Colwill, K., Clausen, M., Chao, G., Yue, F.Y., Fritzler, M., Whitney, J., Thiruvahindrapuram, B., Garant, J.-M., Abraham, R., Davis, A., Campigotto, A., Papenburg, J., Niranjan, K., Betschel, S., Sadarangani, M., Barton-Forbes, M., Hanley, M., Fung, C.Y.J., Lapadula, E., MacDonald, G., Puopolo, M., Kaushik, D., Nirmalanathan, K., Wong, I., Khan, Z., Zarei, N., Michalowska, M., Modi, B.P., Persia, P., Estacio, A., Buchholz, M., Cheatley, P.L., Lorenti, M., Aman, N.F., Matveev, V., Budylowski, P., Upton, J., Morris, S., Boyd, T., Chowdhary, S., Casalino, S., Morgan, G., Mighton, C., McGeer, A., Mazzulli, T., McLeod, S.L., Binnie, A., Faghfoury, H., Chertkow, H., Racher, H., Serbanescu, M.A., Pavenski, K., Esser, M., Thompson, G., Herbrick, J.-A., Gignoux, C.R., Wicks, S.J., Crooks, K., Barnes, K.C., Daya, M., Shortt, J., Rafaels, N., Chavan, S., Ganna, A., Schulze, T.G., Schulte, E.C., Heilbronner, U., Papiol, S., Corbetta, A., Wendtner, C.M., Spinner, C.D., Erber, J., Schneider, J., Winter, C., Wiltfang, J., Budde, M., Senner, F., Kalman, J.L., Protzer, U., Mueller, N.S., Mousas, A., Liontos, A., Christaki, E., Milionis, H., Tsilidis, K., Asimakopoulos, A., Kanellopoulou, A., Markozannes, G., Biros, D., Milionis, O., Tsourlos, S., Athanasiou, L., Kolios, N.-G., Pappa, C., Papathanasiou, A., Pargana, E., Nasiou, M., Kosmidou, M., Rapti, I., Ntotsikas, E., Chaliasos, K., Ntzani, E., Evangelou, E., Gartzonika, K., Georgiou, I., Tzoulaki, I., Ellinghaus, D., Degenhardt, F., C{\'a}ceres, M., Juzenas, S., Lenz, T.L., Albillos, A., Juli{\`a}, A., Prati, D., Sollig?rd, E., Garcia, F., Tran, F., Hanses, F., Baselli, G., Zoller, H., Holter, J.C., Fern{\'a}ndez, J., Barretina, J., Valenti, L., Bujanda, L., Romero-G{\'o}mez, M., Buti, M., D?Amato, M., Banales, J.M., Rosenstiel, P., Koehler, P., Invernizzi, P., de Cid, R., Asselta, R., Schreiber, S., Duga, S., Hehr, U., Franke, A., Maya-Miles, D., Hov, J.R., Karlsen, T.H., Folseraas, T., Teles, A., Tanck, A., Gassner, C., Azuure, C., Wacker, E.M., Uellendahl-Werth, F., Hemmrich-Stanisak, G., ElAbd, H., K, a}ssens, J., Arora, J., Lerga-Jaso, J., Wienbrandt, L., R{\"u}hlemann, M.C., Wendorff, M., Figuera Basso, M.E., Vadla, M.S., Wittig, M., Braun, N., Lenning, O.B., O}zer, O., Myhre, R., Raychaudhuri, S., Wesse, T., Albrecht, W., Yi, X., Ortiz, A.B., de Salazar, A., Chercoles, A.G., Palom, A., Ruiz, A., Garcia-Fernandez, A.-E., Blanco-Grau, A., Mantovani, A., Holten, A.R., Bandera, A., Cherubini, A., Protti, A., Aghemo, A., Gerussi, A., Ramirez, A., Nebel, A., Barreira, A., Lleo, A., Kildal, A.B., Biondi, A., Caballero-Garralda, A., Gori, A., Gl{\"u}ck, A., Lind, A., Nolla, A.C., Latiano, A., Fracanzani, A.L., Peschuck, A., Cavallero, A., Dyrhol-Riise, A.M., Ruello, A., Muscatello, A., Voza, A., Rando-Segura, A., Solier, A., Cortes, B., Mateos, B., Nafria-Jimenez, B., Schaefer, B., Bellinghausen, C., Ferrando, C., de la Horra, C., Quereda, C., Scollo, C., Lange, C., Hu, C., Paccapelo, C., Angelini, C., Cappadona, C., Bianco, C., Cea, C., Sancho, C., Hoff, D.A.L., Galimberti, D., Haschka, D., Jim{\'e}nez, D., Pesta{\~n}a, D., Toapanta, D., Mu{\~n}iz-Diaz, E., Azzolini, E., Sandoval, E., Binatti, E., Scarpini, E., Casalone, E., Urrechaga, E., Paraboschi, E.M., Pontali, E., Reverter, E., Calder{\'o}n, E.J., Navas, E., Contro, E., Arana-Arri, E., Aziz, F., S{\'a}nchez, F.G., Ceriotti, F., Martinelli-Boneschi, F., Peyvandi, F., Blasi, F., Malvestiti, F., Medrano, F.J., Mesonero, F., Rodriguez-Frias, F., M{\"u}ller, F., Bellani, G., Pesenti, A., Zanella, A., Grasselli, G., Pezzoli, G., Costantino, G., Albano, G., Cardamone, G., Bellelli, G., Citerio, G., Foti, G., Lamorte, G., Matullo, G., Kurihara, H., Neb, H., My, I., Hern{\'a}ndez, I., de Rojas, I., Galv{\'a}n-Femenia, I., Afset, J.E., Heyckendorf, J., Dam?s, J.K., Ampuero, J., Mart{\'i}n, J., Erdmann, J., Badia, J.R., Dopazo, J., Bergan, J., Quero, J.H., Goikoetxea, J., Delgado, J., Guerrero, J.M., Risnes, K., Banasik, K., M{\"u}ller, K.E., Gaede, K.I., Garcia-Etxebarria, K., Tonby, K., Heggelund, L., Bettini, L.R., Sumoy, L., Terranova, L., Gustad, L.T., Garbarino, L., Santoro, L., T{\'e}llez, L., Roade, L., Ostadreza, M., Intxausti, M., Kogevinas, M., Riveiro-Barciela, M., Schaefer, M., Guti{\'e}rrez-Stampa, M.A., Carrabba, M., Valsecchi, M.G., Hernandez-Tejero, M., d Vehreschild, M.J.G.T., Manunta, M., Acosta-Herrera, M., D?Angi{\`o}, M., Baldini, M., Cazzaniga, M., Marqui{\'e}, M., Castoldi, M., Cecconi, M., Tomasi, M., Boada, M., Joannidis, M., Mazzocco, M., Ciccarelli, M., Rodr{\'i}guez, i}a, M., Bocciolone, M., Miozzo, M., Ayo, N.I., Blay, N., Chueca, N., Montano, N., Mart{\'i}nez, N., Cornely, O.A., Palmieri, O., Faverio, P., Preatoni, P., Bonfanti, P., Omodei, P., Tentorio, P., Castro, P., Rodrigues, P.M., Izquierdo-Sanchez, L., Espa{\~n}a, P.P., Hoffmann, P., Bacher, P., de Pablo, R., Ferrer, R., Gualtierotti, R., Gallego-Dur{\'a}n, R., Nieto, R., Carpani, R., Morilla, R., Badalamenti, S., Haider, S., Ciesek, S., Bombace, S., Marsal, S., Klein, S., Pelusi, S., Wilfling, S., Goerg, S., Bosari, S., Brunak, S., Heilmann-Heimbach, S., Aliberti, S., Dudman, S., Zheng, T., Bahmer, T., Pumarola, T., Cejudo, T.G., Rimoldi, V., Monzani, V., Skogen, V., Friaza, V., Andrade, V., Moreno, V., Peter, W., Grimsrud, M.M., May, S., Khodamoradi, Y., Virginia, M.-R.A., Dorador, C., Fuentes-Guajardo, M., Silva, A.X., Espinosa-Parrilla, Y., Verdugo, R.A., Y{\'a, n}ez, C.E., Retamales-Ortega, R.M., Saez Hidalgo, J.M., Tobar-Calfucoy, E.A., Carvajal-Silva, L., Mart{\'i}nez, M.F., Cerpa, L.C., Christian, M.A., Cappelli, C., and, Valenzuela-Jorquera, H., Zapata-Contreras, D., Zu{\~n}iga-Pacheco, P., Nova-Lamperti, E.A., Sanhueza, S.A., Donoso, G., Bocchieri, P., Kochifas, P., Qui{\~n}ones, L.A., Banasik, K., Pedersen, O.B., Geller, F., Westergaard, D., Sequeros, C.B., Nissen, J., Nielsen, S.D., Feldt-Rasmussen, U., Bliddal, S., Gr?nb?k, K., Ullum, H., Ostrowski, S.R., Feenstra, B., Shahin, D., Sobh, A., Shoma, A., Corbetta, A., Nkambul, L., Elhadidy, T.A., Abd Elghafar, M.S., El-Jawhari, J.J., Mohamed, A.A.S., Elnagdy, M.H., Samir, A., Abdel-Aziz, M., Khafaga, W.T., El-Lawaty, W.M., Torky, M.S., El-Shanshory, M.R., Elzeiny, A., Rashad, A., Mansour, T.A., Yassen, A.M., Hegazy, M.A.F., Okasha, K., Eid, M.A., Hanteera, M.S., Medina-Gomez, C., Ikram, M.A., Uitterlinden, A.G., Ripatti, S., Jermy, B., Ruotsalainen, S., Kristiansson, K., Koskelainen, S., Perola, M., Donner, K., Kivinen, K., Palotie, A., Kaunisto, M., Julienne, H., Aschard, H., Deleuze, J.-F., Debette, S., Tregouet, D.-A., Abel, L., Henches, L., Lefloch, E., Claire, D.-R., Sakuntabhai, A., Bourgeron, T., Olaso, R., Daian, D.B., Pellegrin, I., Casanova, J.-L., Cobat, A., Jouanguy, E., Zhang, Q., Ghosn, J., Mentr{\'e}, F., Laou{\'e}nan, C., Tubiana, S., Chirouze, C., Quintana-Murci, L., Patin, E., Duffy, D., Boland, A., de Cid, R., Barretina, J., Carreras, A., Moreno, V., Kogevinas, M., Galv{\'a}n-Femen{\'i}a, I., Blay, N., Farr{\'e}, X., Sumoy, L., Cort{\'e}s, B., Mercader, J.M., Guindo-Martinez, M., Torrents, D., Garcia-Aymerich, J., Casta{\~n}o-Vinyals, G., Doba{\~n}o, C., van Heel, D.A., Hunt, K.A., Trembath, R.C., Jacobs, B.M., Huang, Q.Q., Martin, H.C., Mason, D., Trivedi, B., Wright, J., Munisamy, M., van Heel, D.A., Hunt, K.A., Finer, S., Griffiths, C.J., McCarthy, M.I., Rosenberger, C., Lee, J.E., Chang, D., Hammer, C., Hunkapiller, J., Mahajan, A., Pendergrass, R., Sucheston-Campbell, L., Yaspan, B., Lee, H.S., Shin, E., Jang, H.Y., Kim, S., Kym, S., Kim, Y.-S., Jeong, H., Kwon, K.T., Kim, S.-W., Kim, J.Y., Jang, Y.R., Kim, H., Lee, J., Lee, J.E., Lee, S., Choe, K.-W., Kang, Y.M., Jee, S.H., Jung, K.J., Park, H.-Y., Kim, B.-J., Kim, Y.J., Hwang, M.Y., Yoon, K., Pairo-Castineira, E., Rawlik, K., Caulfield, M.J., Baillie, J.K., Griffiths, F., Bretherick, A.D., Stuckey, A., Odhams, C.A., Walker, S., Russell, C.D., Malinauskas, T., Wu, Y., Shen, X., Elliott, K.S., Morrice, K., Keating, S., Wang, B., Rhodes, D., Klaric, L., Zechner, M., Parkinson, N., Fawkes, A., Murphy, L., Vitart, V., Wilson, J.F., Yang, J., Scott, R.H., Moutsianas, L., Law, A., Begg, C., Hendry, S.C., Hinds, C., Horby, P., Knight, J., Ling, L., Maslove, D., McAuley, D., Millar, J., Montgomery, H., Nichol, A., Openshaw, P.J.M., Pereira, A.C., Ponting, C.P., Rowan, K., Semple, M.G., Shankar-Hari, M., Summers, C., Walsh, T., Pan, J., Grau, N., Jones, T.O., Lim, R., Marotti, M., Whitton, C., Bociek, A., Campos, S., Arbane, G., Ostermann, M., Cha, M., DAmato, F., Kosifidou, E., Lorah, S., Morera, K., Brady, L., Hugill, K., Henning, J., Bonner, S., Headlam, E., Jones, J., List, A., Morley, J., Welford, A., Kamangu, B., Ratnakumar, A., Shoremekun, A., Alldis, Z., Astin-Chamberlain, R., Bibi, F., Biddle, J., Blow, S., Bolton, M., Borra, C., Bowles, R., Burton, M., Choudhury, Y., Cox, A., Easthope, A., Ebano, P., Fotiadis, S., Gurasashvili, J., Halls, R., Hartridge, P., Kallon, D., Kassam, J., Lancoma-Malcolm, I., Matharu, M., May, P., Mitchelmore, O., Newman, T., Patel, M., Pheby, J., Pinzuti, I., Prime, Z., Prysyazhna, O., Shiel, J., Taylor, M., Tierney, C., Zongo, O., Wood, S., Zak, A., Collier, D., Mundy, M., Thompson, C., Pritchard, L., Gellamucho, M., Cartlidge, D., Bandla, N., Bailey, L., Davies, M., Delaney, J., Scott, L., Abdelrazik, M., Alasdair, F., Carter, D., Elhassan, M., Ganesan, A., Jenkins, S., Lamond, Z., Purohit, D., Rohit, K., Saleem, M., Wall, A., Xavier, K., Bakthavatsalam, D., Gehad, K., Gnanapragasam, P., Jain, K., Jain, S., Malik, A., Pappachan, N., Moreno-Cuesta, J., Haldeos, A., Vincent, R., Oziegb, M., Cavazza, A., Cockrell, M., Corcoran, E., Depante, M., Finney, C., Jerome, E., Knighton, A., Nayak, M., Pappa, E., Saha, R., Saha, S., Dodd, A., O?Reilly, K., McPhail, M., Clarey, E., Noble, H., Smith, J., Coghlan, P., Brett, S., Gordon, A., Templeton, M., Antcliffe, D., Banach, D., Darnell, S., Fernandez, Z., Jepson, E., Mohammed, A., Rojo, R., Arias, S.S., Gurung, A.T., Wong, J., Fernandez-Roman, J., Hamilton, D.O., Johnson, E., Johnston, B., Martinez, M.L., Mulla, S., Waite, A.A.C., Williams, K., Waugh, V., Welters, I., Emblem, J., Norris, M., Shaw, D., Bashyal, A., Beer, S., Hutton, P., McKechnie, S., Davidson, N., Mathew, S., Readion, G., Ryu, J., Wilson, J., Agrawal, S., Elston, K., Jones, M., Meaney, E., Polgarova, P., Elbehery, M., Daubney, E., Ng, A., Marshall, J., Pathan, N., Stroud, K., White, D., Andrew, A., Ashraf, S., Clark, A., Dent, M., Langley, M., Peters, C., Ryan, L., Sampson, J., Wei, S., Baddeley, A., Meredith, M., Morris, L., Gibbons, A., McLoughlin, L., Delgado, C.C., Clark, V., Dawson, D., Ding, L., Durrant, G., Ezeobu, O., Harrison, A., Hurt, W.J., Kanu, R., Kinch, A., Leaver, S., Lisboa, A., Mathew, J., Patel, K., Saluzzio, R.P., Rawlins, J., Samakomva, T., Shah, N., Sicat, C., Texeira, J., Queiroz, J.G.D., Gloria, E.F.D., Maccacari, E., Yun, N., Manna, S., Farnell-Ward, S., Maizcordoba, M., Thanasi, M., Ali, H.H., Hastings, J., Grauslyte, L., Hussain, M., Ruge, B., King, S., Pogreban, T., Rosaroso, L., Smith, H., Phull, M.-K., Adams, N., Franke, G., George, A., Salciute, E., Wong, J., Dunne, K., Flower, L., Sharland, E., Sra, S., Andrew, G., Callaghan, M., Barclay, L., Marshall, L., Amamio, M., Birch, S., Briton, K., Clark, S., Doverman, K., Hope, D., Mcculloch, C., Simpson, S., Singleton, J., Fernandez, R., Allen, M., Baptista, D., Crowe, R., Fox, J., Khera, J., Loveridge, A., McKenley, I., Morino, E., Naranjo, A., O?Connor, D., Simms, R., Sollesta, K., Swain, A., Venkatesh, H., Herdman-Grant, R., Joseph, A., Nown, A., Rose, S., Pogson, D., Boxall, H., Brimfield, L., Claridge, H., Daly, Z., George, S., Gribbin, A., Cheema, Y., Cutler, S., Richards, O., Roynon-Reed, A., Cherian, S., Heron, A.E., Williams, G., Szakmany, T., Waters, A., Collins, K., Dunhill, J., Jones, F., Morris, R., Ship, L., Cardwell, A., Ali, S., Bhatterjee, R., Bolton, R., Chukkambotla, S., Coleman, D., Dalziel, J., Dykes, J., Fine, C., Gay, B., Goddard, W., Goodchild, D., Harling, R., 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Nature　621　(7977)　2023年

DOI： 10.1038/s41586-023-06355-3 　

ISSN：1476-4687 0028-0836

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Ryuya Edahiro, Yuya Shirai, Yusuke Takeshima, Shuhei Sakakibara, Yuta Yamaguchi, Teruaki Murakami, Takayoshi Morita, Yasuhiro Kato, Yu Chen Liu, Daisuke Motooka, Yoko Naito, Ayako Takuwa, Fuminori Sugihara, Kentaro Tanaka, James B. Wing, Kyuto Sonehara, Yoshihiko Tomofuji, Qingbo S. Wang, Takanori Hasegawa, Ryunosuke Saiki, Takayoshi Hyugaji, Eigo Shimizu, Kotoe Katayama, Masahiro Kanai, Tatsuhiko Naito, Noah Sasa, Kenichi Yamamoto, Kazuhisa Takahashi, Norihiro Harada, Toshio Naito, Makoto Hiki, Yasushi Matsushita, Haruhi Takagi, Masako Ichikawa, Ai Nakamura, Sonoko Harada, Yuuki Sandhu, Hiroki Kabata, Katsunori Masaki, Hirofumi Kamata, Shinnosuke Ikemura, Shotaro Chubachi, Satoshi Okamori, Hideki Terai, Atsuho Morita, Takanori Asakura, Junichi Sasaki, Hiroshi Morisaki, Yoshifumi Uwamino, Kosaku Nanki, Sho Uchida, Shunsuke Uno, Tomoyasu Nishimura, Takashi Ishiguro, Taisuke Isono, Shun Shibata, Yuma Matsui, Chiaki Hosoda, Kenji Takano, Takashi Nishida, Yoichi Kobayashi, Yotaro Takaku, Noboru Takayanagi, Soichiro Ueda, Ai Tada, Masayoshi Miyawaki, Masaomi Yamamoto, Eriko Yoshida, Reina Hayashi, Tomoki Nagasaka, Sawako Arai, Yutaro Kaneko, Kana Sasaki, Etsuko Tagaya, Masatoshi Kawana, Ken Arimura, Kunihiko Takahashi, Tatsuhiko Anzai, Satoshi Ito, Akifumi Endo, Yuji Uchimura, Yasunari Miyazaki, Takayuki Honda, Tomoya Tateishi, Shuji Tohda, Naoya Ichimura, Kazunari Sonobe, Chihiro Tani Sassa, Jun Nakajima, Yasushi Nakano, Yukiko Nakajima, Ryusuke Anan, Ryosuke Arai, Yuko Kurihara, Yuko Harada, Kazumi Nishio, Tetsuya Ueda, Masanori Azuma, Ryuichi Saito, Toshikatsu Sado

Nature Genetics　55　(5)　753-767　2023年

DOI： 10.1038/s41588-023-01375-1 　

ISSN：1061-4036

eISSN：1546-1718

The Association of Lung Function and Carotid Intima-Media Thickness in a Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study. 査読有り

Masato Takase, Mitsuhiro Yamada, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

Journal of atherosclerosis and thrombosis　2022年11月4日

DOI： 10.5551/jat.63826 　

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force. 国際誌

Qingbo S Wang, Ryuya Edahiro, Ho Namkoong, Takanori Hasegawa, Yuya Shirai, Kyuto Sonehara, Hiromu Tanaka, Ho Lee, Ryunosuke Saiki, Takayoshi Hyugaji, Eigo Shimizu, Kotoe Katayama, Masahiro Kanai, Tatsuhiko Naito, Noah Sasa, Kenichi Yamamoto, Yasuhiro Kato, Takayoshi Morita, Kazuhisa Takahashi, Norihiro Harada, Toshio Naito, Makoto Hiki, Yasushi Matsushita, Haruhi Takagi, Masako Ichikawa, Ai Nakamura, Sonoko Harada, Yuuki Sandhu, Hiroki Kabata, Katsunori Masaki, Hirofumi Kamata, Shinnosuke Ikemura, Shotaro Chubachi, Satoshi Okamori, Hideki Terai, Atsuho Morita, Takanori Asakura, Junichi Sasaki, Hiroshi Morisaki, Yoshifumi Uwamino, Kosaku Nanki, Sho Uchida, Shunsuke Uno, Tomoyasu Nishimura, Takashri Ishiguro, Taisuke Isono, Shun Shibata, Yuma Matsui, Chiaki Hosoda, Kenji Takano, Takashi Nishida, Yoichi Kobayashi, Yotaro Takaku, Noboru Takayanagi, Soichiro Ueda, Ai Tada, Masayoshi Miyawaki, Masaomi Yamamoto, Eriko Yoshida, Reina Hayashi, Tomoki Nagasaka, Sawako Arai, Yutaro Kaneko, Kana 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Hirohisa Horinouchi, Fumitake Saito, Keiko Mitamura, Masao Hagihara, Junichi Ochi, Tomoyuki Uchida, Rie Baba, Daisuke Arai, Takayuki Ogura, Hidenori Takahashi, Shigehiro Hagiwara, Genta Nagao, Shunichiro Konishi, Ichiro Nakachi, Koji Murakami, Mitsuhiro Yamada, Hisatoshi Sugiura, Hirohito Sano, Shuichiro Matsumoto, Nozomu Kimura, Yoshinao Ono, Hiroaki Baba, Yusuke Suzuki, Sohei Nakayama, Keita Masuzawa, Shinichi Namba, Takayuki Shiroyama, Yoshimi Noda, Takayuki Niitsu, Yuichi Adachi, Takatoshi Enomoto, Saori Amiya, Reina Hara, Yuta Yamaguchi, Teruaki Murakami, Tomoki Kuge, Kinnosuke Matsumoto, Yuji Yamamoto, Makoto Yamamoto, Midori Yoneda, Kazunori Tomono, Kazuto Kato, Haruhiko Hirata, Yoshito Takeda, Hidefumi Koh, Tadashi Manabe, Yohei Funatsu, Fumimaro Ito, Takahiro Fukui, Keisuke Shinozuka, Sumiko Kohashi, Masatoshi Miyazaki, Tomohisa Shoko, Mitsuaki Kojima, Tomohiro Adachi, Motonao Ishikawa, Kenichiro Takahashi, Takashi Inoue, Toshiyuki Hirano, Keigo Kobayashi, Hatsuyo Takaoka, 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Ohira, Masafumi Watanabe, Sumito Inoue, Akira Igarashi, Masamichi Sato, Hironori Sagara, Akihiko Tanaka, Shin Ohta, Tomoyuki Kimura, Yoko Shibata, Yoshinori Tanino, Takefumi Nikaido, Hiroyuki Minemura, Yuki Sato, Yuichiro Yamada, Takuya Hashino, Masato Shinoki, Hajime Iwagoe, Hiroshi Takahashi, Kazuhiko Fujii, Hiroto Kishi, Masayuki Kanai, Tomonori Imamura, Tatsuya Yamashita, Masakiyo Yatomi, Toshitaka Maeno, Shinichi Hayashi, Mai Takahashi, Mizuki Kuramochi, Isamu Kamimaki, Yoshiteru Tominaga, Tomoo Ishii, Mitsuyoshi Utsugi, Akihiro Ono, Toru Tanaka, Takeru Kashiwada, Kazue Fujita, Yoshinobu Saito, Masahiro Seike, Hiroko Watanabe, Hiroto Matsuse, Norio Kodaka, Chihiro Nakano, Takeshi Oshio, Takatomo Hirouchi, Shohei Makino, Moritoki Egi, Yosuke Omae, Yasuhito Nannya, Takafumi Ueno, Tomomi Takano, Kazuhiko Katayama, Masumi Ai, Atsushi Kumanogoh, Toshiro Sato, Naoki Hasegawa, Katsushi Tokunaga, Makoto Ishii, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga, Yukinori Okada

Nature communications　13　(1)　4830-4830　2022年8月22日

DOI： 10.1038/s41467-022-32276-2 　

DOCK2 is involved in the host genetics and biology of severe COVID-19. 国際誌

Ho Namkoong, Ryuya Edahiro, Tomomi Takano, Hiroshi Nishihara, Yuya Shirai, Kyuto Sonehara, Hiromu Tanaka, Shuhei Azekawa, Yohei Mikami, Ho Lee, Takanori Hasegawa, Koji Okudela, Daisuke Okuzaki, Daisuke Motooka, Masahiro Kanai, Tatsuhiko Naito, Kenichi Yamamoto, Qingbo S Wang, Ryunosuke Saiki, Rino Ishihara, Yuta Matsubara, Junko Hamamoto, Hiroyuki Hayashi, Yukihiro Yoshimura, Natsuo Tachikawa, Emmy Yanagita, Takayoshi Hyugaji, Eigo Shimizu, Kotoe Katayama, Yasuhiro Kato, Takayoshi Morita, Kazuhisa Takahashi, Norihiro Harada, Toshio Naito, Makoto Hiki, Yasushi Matsushita, Haruhi Takagi, Ryousuke Aoki, Ai Nakamura, Sonoko Harada, Hitoshi Sasano, Hiroki Kabata, Katsunori Masaki, Hirofumi Kamata, Shinnosuke Ikemura, Shotaro Chubachi, Satoshi Okamori, Hideki Terai, Atsuho Morita, Takanori Asakura, Junichi Sasaki, Hiroshi Morisaki, Yoshifumi Uwamino, Kosaku Nanki, Sho Uchida, Shunsuke Uno, Tomoyasu Nishimura, Takashi Ishiguro, Taisuke Isono, Shun Shibata, Yuma Matsui, Chiaki Hosoda, Kenji 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Nature　609　(7928)　754-760　2022年8月8日

DOI： 10.1038/s41586-022-05163-5 　

Decreased expression of airway epithelial Axl is associated with eosinophilic inflammation in severe asthma. 国際誌 査読有り

Koji Itakura, Naoya Fujino, Yosuke Kamide, Ikuo Saito, Mitsuhiro Yamada, Koji Okutomo, Yoko Tsukita, Takuya Saito, Tomohiro Ichikawa, Tadahisa Numakura, Yorihiko Kyogoku, Hiroyuki Aizawa, Yoshinao Ono, Shuichiro Matsumoto, Tracy Hussell, Masami Taniguchi, Masakazu Ichinose, Hisatoshi Sugiura

Allergology international : official journal of the Japanese Society of Allergology　71　(3)　383-394　2022年7月

DOI： 10.1016/j.alit.2022.02.010 　

Clinical manifestations of hospitalized influenza patients without risk factors: A prospective multicenter cohort study in Japan via internet surveillance. 国際誌 査読有り

Tadashi Ishida, Masafumi Seki, Kazunori Oishi, Kazuhiro Tateda, Jiro Fujita, Jun-Ichi Kadota, Akihiko Kawana, Koichi Izumikawa, Toshiaki Kikuchi, Norio Ohmagari, Mitsuhiro Yamada, Takaya Maruyama, Takahiro Takazono, Makoto Miki, Yoshitsugu Miyazaki, Yoshitaka Yamazaki, Hiroshi Kakeya, Kenji Ogawa, Hideaki Nagai, Akira Watanabe

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　28　(7)　853-858　2022年4月20日

DOI： 10.1016/j.jiac.2022.02.001 　

Sinobronchial Syndrome Patients with Suspected Non-Tuberculous Mycobacterium Infection Exacerbated by Exophiala dermatitidis Infection. 国際誌 査読有り

Yuji Watanabe, Hirohito Sano, Shuichi Konno, Yasuhiro Kamioka, Maya Hariu, Kazuki Takano, Mitsuhiro Yamada, Masafumi Seki

Infection and drug resistance　15　1135-1141　2022年

DOI： 10.2147/IDR.S359646 　

Increased LHX9 expression in alveolar epithelial type 2 cells of patients with chronic obstructive pulmonary disease. 国際誌 査読有り

Koji Okutomo, Naoya Fujino, Mitsuhiro Yamada, Takuya Saito, Yoshinao Ono, Yoshinori Okada, Masakazu Ichinose, Hisatoshi Sugiura

Respiratory investigation　60　(1)　119-128　2022年1月

DOI： 10.1016/j.resinv.2021.08.007 　

Triple versus LAMA/LABA combination therapy for Japanese patients with COPD: A systematic review and meta-analysis. 国際誌 査読有り

Akira Koarai, Mitsuhiro Yamada, Tomohiro Ichikawa, Naoya Fujino, Tomotaka Kawayama, Hisatoshi Sugiura

Respiratory investigation　60　(1)　90-98　2022年1月

DOI： 10.1016/j.resinv.2021.04.007 　

Mapping the human genetic architecture of COVID-19

Mari E.K. Niemi, Juha Karjalainen, Rachel G. Liao, Benjamin M. Neale, Mark Daly, Andrea Ganna, Gita A. Pathak, Shea J. Andrews, Masahiro Kanai, Kumar Veerapen, Israel Fernandez-Cadenas, Eva C. Schulte, Pasquale Striano, Minttu Marttila, Camelia Minica, Eirini Marouli, Mohd Anisul Karim, Frank R. Wendt, Jeanne Savage, Laura Sloofman, Guillaume Butler-Laporte, Han Na Kim, Stavroula Kanoni, Yukinori Okada, Jinyoung Byun, Younghun Han, Mohammed Jashim Uddin, George Davey Smith, Cristen J. Willer, Joseph D. Buxbaum, Juha Mehtonen, Hilary Finucane, Mattia Cordioli, Alicia R. Martin, Wei Zhou, Bogdan Pasaniuc, Hanna Julienne, Hugues Aschard, Huwenbo Shi, Loic Yengo, Renato Polimanti, Maya Ghoussaini, Jeremy Schwartzentruber, Ian Dunham, Karolina Chwialkowska, Margherita Francescatto, Amy Trankiem, Mary K. Balaconis, Lea Davis, Sulggi Lee, James Priest, Alessandra Renieri, Vijay G. Sankaran, David van Heel, Patrick Deelen, J. Brent Richards, Tomoko Nakanishi, Les Biesecker, V. Eric Kerchberger, J. Kenneth Baillie, Francesca Mari, Anna Bernasconi, Stefano Ceri, Arif Canakoglu, Brooke Wolford, Annika Faucon, Atanu Kumar Dutta, Claudia Schurmann, Emi Harry, Ewan Birney, Huy Nguyen, Jamal Nasir, Mari Kaunisto, Matthew Solomonson, Nicole Dueker, Nirmal Vadgama, Sophie Limou, Souad Rahmouni, Hamdi Mbarek, Dima Darwish, Md Mesbah Uddin, Raquel Albertos, Jordi Pérez-Tur, Ruolin Li, Lasse Folkersen, Ida Moltke, Nils Koelling, Alexander Teumer, Athanasios Kousathanas, Alicia Utrilla, Ricardo A. Verdugo, Ruth Zárate, Carolina Medina-Gómez, David Gómez-Cabrero, Elena Carnero-Montoro, Carmen L. Cadilla, Andrés Moreno-Estrada, Adriana Garmendia, Leire Moya, Bahar Sedaghati-Khayat

Nature　600　(7889)　472-477　2021年12月16日

DOI： 10.1038/s41586-021-03767-x 　

ISSN：0028-0836

eISSN：1476-4687

Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator. 国際誌 査読有り

Mitsuhiro Yamada, Ikuko N Motoike, Kaname Kojima, Nobuo Fuse, Atsushi Hozawa, Shinichi Kuriyama, Fumiki Katsuoka, Shu Tadaka, Matsuyuki Shirota, Miyuki Sakurai, Tomohiro Nakamura, Yohei Hamanaka, Kichiya Suzuki, Junichi Sugawara, Soichi Ogishima, Akira Uruno, Eiichi N Kodama, Naoya Fujino, Tadahisa Numakura, Tomohiro Ichikawa, Ayumi Mitsune, Takashi Ohe, Kengo Kinoshita, Masakazu Ichinose, Hisatoshi Sugiura, Masayuki Yamamoto

Communications biology　4　(1)　1288-1288　2021年11月15日

DOI： 10.1038/s42003-021-02813-8 　

eISSN：2399-3642

Upregulation of leukocyte immunoglobulin-like receptor B4 on interstitial macrophages in COPD; their possible protective role against emphysema formation. 国際誌 査読有り

Ayumi Mitsune, Mitsuhiro Yamada, Naoya Fujino, Tadahisa Numakura, Tomohiro Ichikawa, Ayumi Suzuki, Shuichiro Matsumoto, Yoshiya Mitsuhashi, Koji Itakura, Tomonori Makiguchi, Akira Koarai, Tsutomu Tamada, Shota Endo, Toshiyuki Takai, Yoshinori Okada, Satoshi Suzuki, Masakazu Ichinose, Hisatoshi Sugiura

Respiratory research　22　(1)　232-232　2021年8月23日

DOI： 10.1186/s12931-021-01828-3 　

Triple versus LAMA/LABA combination therapy for patients with COPD: a systematic review and meta-analysis

Akira Koarai, Mitsuhiro Yamada, Tomohiro Ichikawa, Naoya Fujino, Tomotaka Kawayama, Hisatoshi Sugiura

Respiratory research　22　(1)　183　2021年6月22日

DOI： 10.1186/s12931-021-01777-x 　

eISSN：1465-993X

Extracellular vesicles: Their emerging roles in the pathogenesis of respiratory diseases. 国際誌 査読有り

Mitsuhiro Yamada

Respiratory investigation　59　(3)　302-311　2021年5月

DOI： 10.1016/j.resinv.2021.02.006 　

PGC-1α regulates airway epithelial barrier dysfunction induced by house dust mite. 国際誌

Tsutomu Saito, Tomohiro Ichikawa, Tadahisa Numakura, Mitsuhiro Yamada, Akira Koarai, Naoya Fujino, Koji Murakami, Shun Yamanaka, Yusaku Sasaki, Yorihiko Kyogoku, Koji Itakura, Hirohito Sano, Katsuya Takita, Rie Tanaka, Tsutomu Tamada, Masakazu Ichinose, Hisatoshi Sugiura

Respiratory research　22　(1)　63-63　2021年2月19日

DOI： 10.1186/s12931-021-01663-6 　

Longitudinal Relationship Between Growth Differentiation Factor 11 and Physical Activity in Chronic Obstructive Pulmonary Disease. 国際誌

Rie Tanaka, Akira Koarai, Mitsuhiro Yamada, Naoya Fujino, Tomohiro Ichikawa, Tadahisa Numakura, Katsuhiro Onodera, Yorihiko Kyogoku, Tsutomu Tamada, Motohiko Miura, Yoshiaki Minakata, Masakazu Ichinose, Hisatoshi Sugiura

International journal of chronic obstructive pulmonary disease　16　999-1006　2021年

DOI： 10.2147/COPD.S301690 　

Clarithromycin decreases rhinovirus replication and cytokine production in nasal epithelial cells from subjects with bronchial asthma: effects on IL-6, IL-8 and IL-33 査読有り

Mutsuo Yamaya, Kazuhiro Nomura, Kazuya Arakawa, Mitsuru Sugawara, Xue Deng, Nadine Lusamba Kalonji, Hidekazu Nishimura, Mitsuhiro Yamada, Ryoichi Nagatomi, Tetsuaki Kawase

Archives of Pharmacal Research　43　(5)　526-539　2020年5月1日

DOI： 10.1007/s12272-017-0950-x 　

ISSN：0253-6269

eISSN：1976-3786

Treatment with LABA versus LAMA for stable COPD: A systematic review and meta-analysis 査読有り

Akira Koarai, Hisatoshi Sugiura, Mitsuhiro Yamada, Tomohiro Ichikawa, Naoya Fujino, Tomotaka Kawayama, Masakazu Ichinose

BMC Pulmonary Medicine　20　(1)　2020年4月

DOI： 10.1186/s12890-020-1152-8 　

eISSN：1471-2466

Decreased expression of a phagocytic receptor Siglec-1 on alveolar macrophages in chronic obstructive pulmonary disease 査読有り

Atsushi Tanno, Naoya Fujino, Mitsuhiro Yamada, Hisatoshi Sugiura, Taizou Hirano, Rie Tanaka, Hirohito Sano, Satoshi Suzuki, Yoshinori Okada, Masakazu Ichinose

Respiratory Research　21　(1)　2020年1月28日

DOI： 10.1186/s12931-020-1297-2 　

ISSN：1465-9921

eISSN：1465-993X

Clinical manifestations of adult patients requiring influenza-associated hospitalization: A prospective multicenter cohort study in Japan via internet surveillance

Tadashi Ishida, Masafumi Seki, Kazunori Oishi, Kazuhiro Tateda, Jiro Fujita, Jun ichi Kadota, Akihiko Kawana, Koichi Izumikawa, Toshiaki Kikuchi, Norio Ohmagari, Mitsuhiro Yamada, Takaya Maruyama, Takahiro Takazono, Makoto Miki, Yoshitsugu Miyazaki, Yoshitaka Yamazaki, Hiroshi Kakeya, Kenji Ogawa, Hideaki Nagai, Akira Watanabe

Journal of Infection and Chemotherapy　2020年

DOI： 10.1016/j.jiac.2020.10.021 　

ISSN：1341-321X

eISSN：1437-7780

The Roles of MicroRNAs and Extracellular Vesicles in the Pathogeneses of Idiopathic Pulmonary Fibrosis and Acute Respiratory Distress Syndrome. 査読有り

Mitsuhiro Yamada

The Tohoku journal of experimental medicine　251　(4)　313-326　2020年

DOI： 10.1620/tjem.251.313 　

Improving the viability of tissue-resident stem cells using an organ-preservation solution 査読有り

Takaya Suzuki, Chiharu Ota, Naoya Fujino, Yukiko Tando, Satoshi Suzuki, Mitsuhiro Yamada, Takashi Kondo, Yoshinori Okada, Hiroshi Kubo

FEBS Open Bio　9　(12)　2093-2104　2019年12月1日

DOI： 10.1002/2211-5463.12748 　

eISSN：2211-5463

Nitrosative stress in patients with asthma–chronic obstructive pulmonary disease overlap 査読有り

Yorihiko Kyogoku, Hisatoshi Sugiura, Tomohiro Ichikawa, Tadahisa Numakura, Akira Koarai, Mitsuhiro Yamada, Naoya Fujino, Yutaka Tojo, Katsuhiro Onodera, Rie Tanaka, Kei Sato, Hirohito Sano, Shun Yamanaka, Koji Itakura, Ayumi Mitsune, Tsutomu Tamada, Takaaki Akaike, Masakazu Ichinose

Journal of Allergy and Clinical Immunology　144　(4)　972-983　2019年10月

DOI： 10.1016/j.jaci.2019.04.023 　

ISSN：0091-6749

eISSN：1097-6825

Increase in circulating ACE-positive endothelial microparticles during acute lung injury 査読有り

Yusuke Takei, Mitsuhiro Yamada, Koji Saito, Yoshinobu Kameyama, Hisatoshi Sugiura, Tomonori Makiguchi, Naoya Fujino, Akira Koarai, Hiroaki Toyama, Kazutomo Saito, Yutaka Ejima, Yu Kawazoe, Daisuke Kudo, Shigeki Kushimoto, Masanori Yamauchi, Masakazu Ichinose

The European respiratory journal　54　(4)　2019年10月1日

DOI： 10.1183/13993003.01188-2018 　

ISSN：0903-1936

eISSN：1399-3003

Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases 査読有り

Naoya Fujino, Oliver J. Brand, David J. Morgan, Toshifumi Fujimori, Aleksander M. Grabiec, Christopher P. Jagger, Rose A. Maciewicz, Mitsuhiro Yamada, Koji Itakura, Hisatoshi Sugiura, Masakazu Ichinose, Tracy Hussell

Journal of Experimental Medicine　216　(9)　2184-2201　2019年9月1日

DOI： 10.1084/jem.20171978 　

ISSN：0022-1007

eISSN：1540-9538

Axl kinase drives immune checkpoint and chemokine signalling pathways in lung adenocarcinomas 査読有り

Yoko Tsukita, Naoya Fujino, Eisaku Miyauchi, Ryoko Saito, Fumiyoshi Fujishima, Koji Itakura, Yorihiko Kyogoku, Koji Okutomo, Mitsuhiro Yamada, Tatsuma Okazaki, Hisatoshi Sugiura, Akira Inoue, Yoshinori Okada, Masakazu Ichinose

Molecular Cancer　18　(1)　24　2019年2月11日

DOI： 10.1186/s12943-019-0953-y 　

eISSN：1476-4598

The cholinergic pathways in inflammation: A potential pharmacotherapeutic target for COPD 査読有り

Mitsuhiro Yamada, Masakazu Ichinose

Frontiers in Pharmacology　9　1426-1426　2018年12月

DOI： 10.3389/fphar.2018.01426 　

eISSN：1663-9812

Management of De Novo Mycobacterial Infection After Lung Transplantation Without Rifampicin: Case Series of a Single Institution 査読有り

H. Suzuki, Y. Matsuda, M. Noda, H. Oishi, T. Watanabe, T. Sado, M. Yamada, T. Tamada, Y. Okada

Transplantation Proceedings　50　(9)　2764-2767　2018年11月

DOI： 10.1016/j.transproceed.2018.03.058 　

ISSN：0041-1345

eISSN：1873-2623

Expression of cytochrome P450 mRNAs in Type II alveolar cells from subjects with chronic obstructive pulmonary disease 査読有り

Satoshi Kamata, Naoya Fujino, Mitsuhiro Yamada, Ken Grime, Satoshi Suzuki, Chiharu Ota, Yukiko Tando, Yoshinori Okada, Akira Sakurada, Masafumi Noda, Yasushi Matsuda, Hisatoshi Sugiura, Masakazu Ichinose

Pharmacology Research and Perspectives　6　(3)　2018年6月

DOI： 10.1002/prp2.405 　

eISSN：2052-1707

The cholinergic anti-inflammatory pathway: an innovative treatment strategy for respiratory diseases and their comorbidities 査読有り

Mitsuhiro Yamada, Masakazu Ichinose

Current Opinion in Pharmacology　40　18-25　2018年6月

DOI： 10.1016/j.coph.2017.12.003 　

ISSN：1471-4892

eISSN：1471-4973

Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease 査読有り

Rie Tanaka, Hisatoshi Sugiura, Mitsuhiro Yamada, Tomohiro Ichikawa, Akira Koarai, Naoya Fujino, Satoru Yanagisawa, Katsuhiro Onodera, Tadahisa Numakura, Kei Sato, Yorihiko Kyogoku, Hirohito Sano, Shun Yamanaka, Tatsuma Okazaki, Tsutomu Tamada, Motohiko Miura, Tsuneyuki Takahashi, Masakazu Ichinose

International Journal of COPD　13　1333-1342　2018年4月

DOI： 10.2147/COPD.S157035 　

ISSN：1176-9106

eISSN：1178-2005

Oxidative stress enhances the expression of IL-33 in human airway epithelial cells 査読有り

Hiroyuki Aizawa, Akira Koarai, Yutaka Shishikura, Satoru Yanagisawa, Mutsuo Yamaya, Hisatoshi Sugiura, Tadahisa Numakura, Mitsuhiro Yamada, Tomohiro Ichikawa, Naoya Fujino, Masafumi Noda, Yoshinori Okada, Masakazu Ichinose

Respiratory Research　19　(1)　2018年3月27日

DOI： 10.1186/s12931-018-0752-9 　

ISSN：1465-9921

eISSN：1465-993X

Correction: Oxidative stress enhances the expression of IL-33 in human airway epithelial cells. [Respir Res., 19, (2018) (52)] DOI: 10.1186/s12931-018-0752-9

Aizawa, H., Koarai, A., Shishikura, Y., Yanagisawa, S., Yamaya, M., Sugiura, H., Numakura, T., Yamada, M., Ichikawa, T., Fujino, N., Noda, M., Okada, Y., Ichinose, M.

Respiratory Research　19　(1)　2018年

DOI： 10.1186/s12931-018-0817-9 　

ISSN：1465-993X 1465-9921

Clinical characteristics and outcomes in Japanese patients with COPD according to the 2017 GOLD classification: The ishinomaki COPD network registry 査読有り

Seiichi Kobayashi, Masakazu Hanagama, Masatsugu Ishida, Hikari Sato, Manabu Ono, Shinsuke Yamanda, Mitsuhiro Yamada, Hiroyuki Aizawa, Masaru Yanai

International Journal of COPD　13　3947-3955　2018年

DOI： 10.2147/COPD.S182905 　

ISSN：1176-9106

eISSN：1178-2005

Production of reactive persulfide species in chronic obstructive pulmonary disease 査読有り

Tadahisa Numakura, Hisatoshi Sugiura, Takaaki Akaike, Tomoaki Ida, Shigemoto Fujii, Akira Koarai, Mitsuhiro Yamada, Katsuhiro Onodera, Yuichiro Hashimoto, Rie Tanaka, Kei Sato, Yutaka Shishikura, Taizou Hirano, Satoru Yanagisawa, Naoya Fujino, Tatsuma Okazaki, Tsutomu Tamada, Yasushi Hoshikawa, Yoshinori Okada, Masakazu Ichinose

Thorax　72　(12)　1074-1083　2017年12月1日

DOI： 10.1136/thoraxjnl-2016-209359 　

ISSN：0040-6376

eISSN：1468-3296

Chronic Cholestasis with Dilation of Intrahepatic Bile Duct Related to Administration of Ceritinib 査読有り

Taizou Hirano, Mitsuhiro Yamada, Masakazu Ichinose

Journal of Thoracic Oncology　12　(8)　e123-e125　2017年8月

DOI： 10.1016/j.jtho.2017.04.006 　

ISSN：1556-0864

eISSN：1556-1380

Invasive pulmonary mucormycosis: Rare presentation with pulmonary eosinophilia 査読有り

Taizou Hirano, Mitsuhiro Yamada, Kei Sato, Koji Murakami, Tokiwa Tamai, Yoshiya Mitsuhashi, Tsutomu Tamada, Hisatoshi Sugiura, Naomi Sato, Ryoko Saito, Junya Tominaga, Akira Watanabe, Masakazu Ichinose

BMC Pulmonary Medicine　17　(1)　2017年4月

DOI： 10.1186/s12890-017-0419-1 　

eISSN：1471-2466

Decrease in an anti-ageing factor, growth differentiation factor 11, in chronic obstructive pulmonary disease 査読有り

Katsuhiro Onodera, Hisatoshi Sugiura, Mitsuhiro Yamada, Akira Koarai, Naoya Fujino, Satoru Yanagisawa, Rie Tanaka, Tadahisa Numakura, Shinsaku Togo, Kei Sato, Yorihiko Kyogoku, Yuichiro Hashimoto, Tatsuma Okazaki, Tsutomu Tamada, Seiichi Kobayashi, Masaru Yanai, Motohiko Miura, Yasushi Hoshikawa, Yoshinori Okada, Satoshi Suzuki, Masakazu Ichinose

Thorax　72　(10)　893-904　2017年4月

DOI： 10.1136/thoraxjnl-2016-209352 　

ISSN：0040-6376

eISSN：1468-3296

Extracellular ATP is involved in dsRNA-induced MUC5AC production via P2Y2R in human airway epithelium 査読有り

Yutaka Shishikura, Akira Koarai, Hiroyuki Aizawa, Mutsuo Yamaya, Hisatoshi Sugiura, Mika Watanabe, Yuichiro Hashimoto, Tadahisa Numakura, Tomonori Makiguti, Kyoko Abe, Mituhiro Yamada, Toshiaki Kikuchi, Yasushi Hoshikawa, Yoshinori Okada, Masakazu Ichinose

Respiratory Research　17　(1)　2016年9月27日

DOI： 10.1186/s12931-016-0438-0 　

ISSN：1465-9921

eISSN：1465-993X

Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis 査読有り

Tomonori Makiguchi, Mitsuhiro Yamada, Yusuke Yoshioka, Hisatoshi Sugiura, Akira Koarai, Shigeki Chiba, Naoya Fujino, Yutaka Tojo, Chiharu Ota, Hiroshi Kubo, Seiichi Kobayashi, Masaru Yanai, Sanae Shimura, Takahiro Ochiya, Masakazu Ichinose

Respiratory Research　17　(1)　2016年9月5日

DOI： 10.1186/s12931-016-0427-3 　

ISSN：1465-9921

eISSN：1465-993X

27-Hydroxycholesterol accelerates cellular senescence in human lung resident cells 査読有り

Yuichiro Hashimoto, Hisatoshi Sugiura, Shinsaku Togo, Akira Koarai, Kyoko Abe, Mitsuhiro Yamada, Tomohiro Ichikawa, Takashi Kikuchi, Tadahisa Numakura, Katsuhiro Onodera, Rie Tanaka, Kei Sato, Satoru Yanagisawa, Tatsuma Okazaki, Tsutomu Tamada, Toshiaki Kikuchi, Yasushi Hoshikawa, Yoshinori Okada, Masakazu Ichinose

American Journal of Physiology - Lung Cellular and Molecular Physiology　310　(11)　L1028-L1041　2016年6月1日

DOI： 10.1152/ajplung.00351.2015 　

ISSN：1040-0605

eISSN：1522-1504

Two cases of endobronchial aspergilloma complicated with primary and metastatic lung cancer: A case report and literature review 査読有り

Taizou Hirano, Mitsuhiro Yamada, Ryotaro Igusa, Atsushi Tanno, Tadahisa Numakura, Kazuhiro Sakamoto, Toshiaki Kikuchi, Masakazu Ichinose

Respiratory Investigation　54　(3)　211-215　2016年5月1日

DOI： 10.1016/j.resinv.2015.12.005 　

ISSN：2212-5345

eISSN：2212-5353

Novel Monoclonal Antibody LpMab-17 Developed by CasMab Technology Distinguishes Human Podoplanin from Monkey Podoplanin 査読有り

Yukinari Kato, Satoshi Ogasawara, Hiroharu Oki, Ryusuke Honma, Michiaki Takagi, Yuki Fujii, Takuro Nakamura, Noriko Saidoh, Hazuki Kanno, Mitsuo Umetsu, Satoshi Kamata, Hiroshi Kubo, Mitsuhiro Yamada, Yoshihiko Sawa, Kei Ichi Morita, Hiroyuki Harada, Hiroyoshi Suzuki, Mika Kato Kaneko

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy　35　(2)　109-116　2016年4月

DOI： 10.1089/mab.2015.0077 　

eISSN：2167-9436

OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia 査読有り

Taizou Hirano, Toshiaki Kikuchi, Naoki Tode, Arif Santoso, Mitsuhiro Yamada, Yoshiya Mitsuhashi, Riyo Komatsu, Takeshi Kawabe, Takeshi Tanimoto, Naoto Ishii, Yuetsu Tanaka, Hidekazu Nishimura, Toshihiro Nukiwa, Akira Watanabe, Masakazu Ichinose

EMBO Molecular Medicine　8　(4)　422-436　2016年4月

DOI： 10.15252/emmm.201506154 　

ISSN：1757-4676

eISSN：1757-4684

Receptor for advanced glycation end products expressed on alveolar epithelial cells is the main target for hyperoxia-induced lung injury 査読有り

Chiharu Ota, Kota Ishizawa, Mitsuhiro Yamada, Yukiko Tando, Mei He, Toru Takahashi, Mutsuo Yamaya, Yasuhiko Yamamoto, Hiroshi Yamamoto, Shigeo Kure, Hiroshi Kubo

Respiratory Investigation　54　(2)　98-108　2016年3月1日

DOI： 10.1016/j.resinv.2015.08.009 　

ISSN：2212-5345

eISSN：2212-5353

Possible role of Krüppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease 査読有り

Kyoko Abe, Hisatoshi Sugiura, Yuichiro Hashimoto, Tomohiro Ichikawa, Akira Koarai, Mitsuhiro Yamada, Tadahisa Numakura, Katsuhiro Onodera, Rie Tanaka, Kei Sato, Satoru Yanagisawa, Tatsuma Okazaki, Tsutomu Tamada, Toshiaki Kikuchi, Masakazu Ichinose

Respiratory Research　17　(1)　2016年1月20日

DOI： 10.1186/s12931-016-0322-y 　

ISSN：1465-9921

eISSN：1465-993X

Inflammatory responses in the initiation of lung repair and regeneration: Their role in stimulating lung resident stem cells 査読有り

Mitsuhiro Yamada, Naoya Fujino, Masakazu Ichinose

Inflammation and Regeneration　36　(1)　15-15　2016年

DOI： 10.1186/s41232-016-0020-7 　

eISSN：1880-8190

Histone deacetylase inhibitor restores surfactant protein-C expression in alveolar-epithelial type II cells and attenuates bleomycin-induced pulmonary fibrosis in vivo 査読有り

Chiharu Ota, Mitsuhiro Yamada, Naoya Fujino, Hozumi Motohashi, Yukiko Tando, Yusuke Takei, Takaya Suzuki, Toru Takahashi, Satoshi Kamata, Tomonori Makiguchi, Mutsuo Yamaya, Hiroshi Kubo

Experimental Lung Research　41　(8)　422-434　2015年9月14日

DOI： 10.3109/01902148.2015.1060275 　

ISSN：0190-2148

eISSN：1521-0499

Mechanisms of interferon-γ production by neutrophils and its function during streptococcus pneumoniae pneumonia 査読有り

John C. Gomez, Mitsuhiro Yamada, Jessica R. Martin, Hong Dang, W. June Brickey, Wolfgang Bergmeier, Mary C. Dinauer, Claire M. Doerschuk

American Journal of Respiratory Cell and Molecular Biology　52　(3)　349-364　2015年3月1日

DOI： 10.1165/rcmb.2013-0316OC 　

ISSN：1044-1549

eISSN：1535-4989

The Role of Lysophosphatidic Acid on Airway Epithelial Cell Denudation in a Murine Heterotopic Tracheal Transplant Model 査読有り

Tando Y, Ota C, Yamada M, Kamata S, Yamaya M, Kano K, Okudaira S, Aoki J, Kubo H

Transplant Direct　1　(9)　e35　2015年

DOI： 10.1097/TXD.0000000000000542 　

Cutting edge of COPD therapy: Current pharmacological therapy and future direction 査読有り

Mitsuhiro Yamada, Masakazu Ichinose

COPD Research and Practice　1　(1)　2015年

DOI： 10.1186/s40749-015-0009-7 　

eISSN：2054-9040

c-Kit immunoexpression delineates a putative endothelial progenitor cell population in developing human lungs 査読有り

Takaya Suzuki, Satoshi Suzuki, Naoya Fujino, Chiharu Ota, Mitsuhiro Yamada, Takashi Suzuki, Mutsuo Yamaya, Takashi Kondo, Hiroshi Kubo

American Journal of Physiology - Lung Cellular and Molecular Physiology　306　(9)　L855-L865　2014年5月1日

DOI： 10.1152/ajplung.00211.2013 　

ISSN：1040-0605

eISSN：1522-1504

Annual FEV<inf>1</inf> changes and numbers of circulating endothelial microparticles in patients with COPD: A prospective study 査読有り

Toru Takahashi, Seiichi Kobayashi, Naoya Fujino, Takaya Suzuki, Chiharu Ota, Yukiko Tando, Mitsuhiro Yamada, Masaru Yanai, Mutsuo Yamaya, Shin Kurosawa, Masanori Yamauchi, Hiroshi Kubo

BMJ Open　4　(3)　2014年

DOI： 10.1136/bmjopen-2013-004571 　

eISSN：2044-6055

Plasma mitochondrial DNA levels in patients with trauma and severe sepsis: Time course and the association with clinical status 査読有り

Satoshi Yamanouchi, Daisuke Kudo, Mitsuhiro Yamada, Noriko Miyagawa, Hajime Furukawa, Shigeki Kushimoto

Journal of Critical Care　28　(6)　1027-1031　2013年12月

DOI： 10.1016/j.jcrc.2013.05.006 　

ISSN：0883-9441

eISSN：1557-8615

The increase of microRNA-21 during lung fibrosis and its contribution to epithelial-mesenchymal transition in pulmonary epithelial cells 査読有り

Mitsuhiro Yamada, Hiroshi Kubo, Chiharu Ota, Toru Takahashi, Yukiko Tando, Takaya Suzuki, Naoya Fujino, Tomonori Makiguchi, Kiyoshi Takagi, Takashi Suzuki, Masakazu Ichinose

Respiratory Research　14　(1)　2013年9月24日

DOI： 10.1186/1465-9921-14-95 　

ISSN：1465-9921

eISSN：1465-993X

Molecular Characteristics of Extended-Spectrum β-Lactamases in Clinical Isolates from Escherichia coli at a Japanese Tertiary Hospital 査読有り

Hisakazu Yano, Mina Uemura, Shiro Endo, Hajime Kanamori, Shinya Inomata, Risako Kakuta, Sadahiro Ichimura, Miho Ogawa, Masahiro Shimojima, Noriomi Ishibashi, Tetsuji Aoyagi, Masumitsu Hatta, Yoshiaki Gu, Mitsuhiro Yamada, Koichi Tokuda, Hiroyuki Kunishima, Miho Kitagawa, Yoichi Hirakata, Mitsuo Kaku

PLoS ONE　8　(5)　2013年5月15日

DOI： 10.1371/journal.pone.0064359 　

eISSN：1932-6203

Tuberculosis exposure among evacuees at a shelter after earthquake, Japan, 2011 査読有り

Hajime Kanamori, Noboru Aso, Satoko Tadano, Miyoko Saito, Hiroo Saito, Bine Uchiyama, Noriomi Ishibashi, Shinya Inomata, Shiro Endo, Tetsuji Aoyagi, Masumitsu Hatta, Mitsuhiro Yamada, Yoshiaki Gu, Koichi Tokuda, Hisakazu Yano, Hiroyuki Kunishima, Yoichi Hirakata, Takao Saijyo, Miho Kitagawa, Mitsuo Kaku

Emerging Infectious Diseases　19　(5)　799-801　2013年5月

DOI： 10.3201/eid1905.121137 　

ISSN：1080-6040

eISSN：1080-6059

Increased severity of 2009 pandemic influenza A virus subtype H1N1 infection in alveolar type II cells from patients with pulmonary fibrosis. 査読有り

Naoya Fujino, Hiroshi Kubo, Chiharu Ota, Takaya Suzuki, Toru Takahashi, Mitsuhiro Yamada, Satoshi Suzuki, Takashi Kondo, Ryouichi Nagatomi, Yukiko Tando, Mutsuo Yamaya

The Journal of infectious diseases　207　(4)　692-693　2013年2月15日

DOI： 10.1093/infdis/jis739 　

eISSN：1537-6613

Characteristics of infectious diseases in hospitalized patients during the early phase after the 2011 great east japan earthquake pneumonia as a signifi cant reason for hospital care 査読有り

Tetsuji Aoyagi, Mitsuhiro Yamada, Hiroyuki Kunishima, Koichi Tokuda, Hisakazu Yano, Noriomi Ishibashi, Masumitsu Hatta, Shiro Endo, Kazuaki Arai, Shinya Inomata, Yoshiaki Gu, Hajime Kanamori, Miho Kitagawa, Yoichi Hirakata, Mitsuo Kaku

Chest　143　(2)　349-356　2013年2月

DOI： 10.1378/chest.11-3298 　

ISSN：0012-3692

eISSN：1931-3543

Differences in the released endothelial microparticle subtypes between human pulmonary microvascular endothelial cells and aortic endothelial cells in vitro 査読有り

Toru Takahashi, Seiichi Kobayashi, Naoya Fujino, Takaya Suzuki, Chiharu Ota, Yukiko Tando, Mei He, Mitsuhiro Yamada, Shin Kurosawa, Mutsuo Yamaya, Hiroshi Kubo

Experimental Lung Research　39　(4-5)　155-161　2013年

DOI： 10.3109/01902148.2013.784932 　

ISSN：0190-2148

eISSN：1521-0499

Increased circulating endothelial microparticles in COPD patients: A potential biomarker for COPD exacerbation susceptibility 査読有り

Toru Takahashi, Seiichi Kobayashi, Naoya Fujino, Takaya Suzuki, Chiharu Ota, Mei He, Mitsuhiro Yamada, Satoshi Suzuki, Masaru Yanai, Shin Kurosawa, Mutsuo Yamaya, Hiroshi Kubo

Thorax　67　(12)　1067-1074　2012年12月

DOI： 10.1136/thoraxjnl-2011-201395 　

ISSN：0040-6376

eISSN：1468-3296

Imp-1-producing carbapenem-resistant acinetobacter ursingii from Japan 査読有り

Shiro Endo, Mina Sasano, Hisakazu Yano, Shinya Inomata, Noriomi Ishibashi, Tetsuji Aoyagi, Masumitsu Hatta, Yoshiaki Gu, Mitsuhiro Yamada, Koichi Tokuda, Miho Kitagawa, Hiroyuki Kunishima, Yoichi Hirakata, Mitsuo Kaku

Journal of Antimicrobial Chemotherapy　67　(10)　2533-2534　2012年10月

DOI： 10.1093/jac/dks249 　

ISSN：0305-7453

eISSN：1460-2091

Surgical stress increases circulating endothelial microparticles in the elderly 査読有り

T. Takahashi, H. Kubo, N. Fujino, T. Suzuki, C. Ota, M. Yamada, M. Yamaya, S. Suzuki, S. Kurosawa

Anaesthesia and Intensive Care　40　(5)　899-902　2012年9月

ISSN：0310-057X

eISSN：1448-0271

Analysis of gene expression profiles in alveolar epithelial type II-like cells differentiated from human alveolar epithelial progenitor cells 査読有り

Naoya Fujino, Chiharu Ota, Takaya Suzuki, Satoshi Suzuki, Ahmed E. Hegab, Mitsuhiro Yamada, Toru Takahashi, Mei He, Takashi Kondo, Hidemasa Kato, Mutsuo Yamaya, Hiroshi Kubo

Respiratory Investigation　50　(3)　110-116　2012年9月

DOI： 10.1016/j.resinv.2012.07.002 　

ISSN：2212-5345

High frequency of IMP-6 among clinical isolates of metallo-β- lactamase-producing Escherichia coli in Japan 査読有り

Hisakazu Yano, Miho Ogawa, Shiro Endo, Risako Kakuta, Hajime Kanamori, Shinya Inomata, Noriomi Ishibashi, Tetsuji Aoyagi, Masumitsu Hatta, Yoshiaki Gu, Mitsuhiro Yamada, Koichi Tokuda, Hiroyuki Kunishima, Miho Kitagawa, Yoichi Hirakata, Mitsuo Kaku

Antimicrobial Agents and Chemotherapy　56　(8)　4554-4555　2012年8月

DOI： 10.1128/AAC.00617-12 　

ISSN：0066-4804

eISSN：1098-6596

Molecular epidemiology of carbapenem-non-susceptible acinetobacter baumannii in Japan 査読有り

Shiro Endo, Hisakazu Yano, Yoichi Hirakata, Kazuaki Arai, Hajime Kanamori, Miho Ogawa, Masahiro Shimojima, Noriomi Ishibashi, Tetsuji Aoyagi, Masumitsu Hatta, Mitsuhiro Yamada, Koichi Tokuda, Miho Kitagawa, Hiroyuki Kunishima, Mitsuo Kaku

Journal of Antimicrobial Chemotherapy　67　(7)　1623-1626　2012年7月

DOI： 10.1093/jac/dks094 　

ISSN：0305-7453

eISSN：1460-2091

Molecular characteristics of extended-spectrum beta-lactamases and qnr determinants in Enterobacter species from Japan 査読有り

Hajime Kanamori, Hisakazu Yano, Yoichi Hirakata, Ayako Hirotani, Kazuaki Arai, Shiro Endo, Sadahiro Ichimura, Miho Ogawa, Masahiro Shimojima, Tetsuji Aoyagi, Masumitsu Hatta, Mitsuhiro Yamada, Yoshiaki Gu, Koichi Tokuda, Hiroyuki Kunishima, Miho Kitagawa, Mitsuo Kaku

PLoS ONE　7　(6)　2012年6月15日

DOI： 10.1371/journal.pone.0037967 　

eISSN：1932-6203

First carbapenem-resistant isolates of Acinetobacter soli in Japan 査読有り

Shiro Endo, Mina Sasano, Hisakazu Yano, Kazuaki Arai, Tetsuji Aoyagi, Masumitsu Hatta, Yoshiaki Gu, Mitsuhiro Yamada, Koichi Tokuda, Miho Ogawa, Masahiro Shimojima, Miho Kitagawa, Hiroyuki Kunishima, Yoichi Hirakata, Mitsuo Kaku

Antimicrobial Agents and Chemotherapy　56　(5)　2786-2787　2012年5月

DOI： 10.1128/AAC.00021-12 　

ISSN：0066-4804

eISSN：1098-6596

A novel method for isolating individual cellular components from the adult human distal lung 査読有り

Naoya Fujino, Hiroshi Kubo, Chiharu Ota, Takaya Suzuki, Satoshi Suzuki, Mitsuhiro Yamada, Toru Takahashi, Mei He, Takashi Suzuki, Takashi Kondo, Mutsuo Yamaya

American Journal of Respiratory Cell and Molecular Biology　46　(4)　422-430　2012年4月

DOI： 10.1165/rcmb.2011-0172OC 　

ISSN：1044-1549

Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice 査読有り

Naoya Fujino, Hiroshi Kubo, Tomoko Suzuki, Mei He, Takaya Suzuki, Mitsuhiro Yamada, Toru Takahashi, Chiharu Ota, Mutsuo Yamaya

Experimental Lung Research　38　(1)　28-36　2012年2月

DOI： 10.3109/01902148.2011.633306 　

ISSN：0190-2148

eISSN：1521-0499

Post-tsunami outbreaks of influenza in evacuation centers in miyagi prefecture, Japan 査読有り

Masumitsu Hatta, Shiro Endo, Koichi Tokuda, Hiroyuki Kunishima, Kazuaki Arai, Hisakazu Yano, Noriomi Ishibashi, Tetsuji Aoyagi, Mitsuhiro Yamada, Shinya Inomata, Hajime Kanamori, Yoshiaki Gu, Miho Kitagawa, Yoichi Hirakata, Mitsuo Kaku

Clinical Infectious Diseases　54　(1)　E5-E7　2012年1月1日

DOI： 10.1093/cid/cir752 　

ISSN：1058-4838

eISSN：1537-6591

Gene expression profiles of alveolar type II cells of chronic obstructive pulmonary disease: A case-control study 査読有り

Naoya Fujino, Chiharu Ota, Toru Takahashi, Takaya Suzuki, Satoshi Suzuki, Mitsuhiro Yamada, Ryouichi Nagatomi, Takashi Kondo, Mutsuo Yamaya, Hiroshi Kubo

BMJ Open　2　(6)　2012年

DOI： 10.1136/bmjopen-2012-001553 　

eISSN：2044-6055

High prevalence of extended-spectrum β-lactamases and qnr determinants in citrobacter species from japan: Dissemination of CTX-M-2 査読有り

Hajime Kanamori, Hisakazu Yano, Yoichi Hirakata, Shiro Endo, Kazuaki Arai, Miho Ogawa, Masahiro Shimojima, Tetsuji Aoyagi, Masumitsu Hatta, Mitsuhiro Yamada, Katsushi Nishimaki, Miho Kitagawa, Hiroyuki Kunishima, Mitsuo Kaku

Journal of Antimicrobial Chemotherapy　66　(10)　2255-2262　2011年10月

DOI： 10.1093/jac/dkr283 　

ISSN：0305-7453

eISSN：1460-2091

The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury 査読有り

Mitsuhiro Yamada, Hiroshi Kubo, Seiichi Kobayashi, Kota Ishizawa, Mei He, Takaya Suzuki, Naoya Fujino, Hiroyuki Kunishima, Masamitsu Hatta, Katsushi Nishimaki, Tetsuji Aoyagi, Kouichi Tokuda, Miho Kitagawa, Hisakazu Yano, Hirokazu Tamamura, Nobutaka Fujii, Mitsuo Kaku

Cellular and Molecular Immunology　8　(4)　305-314　2011年7月

DOI： 10.1038/cmi.2011.8 　

ISSN：1672-7681

Interferon-γ production by neutrophils during bacterial pneumonia in mice 査読有り

Mitsuhiro Yamada, John C. Gomez, Pauline E. Chugh, Clifford A. Lowell, Mary C. Dinauer, Dirk P. Dittmer, Claire M. Doerschuk

American Journal of Respiratory and Critical Care Medicine　183　(10)　1391-1401　2011年5月15日

DOI： 10.1164/rccm.201004-0592OC 　

ISSN：1073-449X

eISSN：1535-4970

Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells 査読有り

Mei He, Hiroshi Kubo, Konosuke Morimoto, Naoya Fujino, Takaya Suzuki, Toru Takahasi, Mitsuhiro Yamada, Mutsuo Yamaya, Tomoyuki Maekawa, Yasuhiko Yamamoto, Hiroshi Yamamoto

EMBO Reports　12　(4)　358-364　2011年4月

DOI： 10.1038/embor.2011.28 　

ISSN：1469-221X

eISSN：1469-3178

Isolation of alveolar epithelial type II progenitor cells from adult human lungs 査読有り

Naoya Fujino, Hiroshi Kubo, Takaya Suzuki, Chiharu Ota, Ahmed E. Hegab, Mei He, Satoshi Suzuki, Takashi Suzuki, Mitsuhiro Yamada, Takashi Kondo, Hidemasa Kato, Mutsuo Yamaya

Laboratory Investigation　91　(3)　363-378　2011年3月

DOI： 10.1038/labinvest.2010.187 　

ISSN：0023-6837

eISSN：1530-0307

Emergence of fluoroquinolone-resistant Streptococcus pyogenes in Japan by a point mutation leading to a new amino acid substitution 査読有り

Kazuaki Arai, Yoichi Hirakata, Hisakazu Yano, Hajime Kanamori, Shiro Endo, Ayako Hirotani, Yuko Abe, Mitsuaki Nagasawa, Miho Kitagawa, Tetsuji Aoyagi, Masumitsu Hatta, Mitsuhiro Yamada, Katsushi Nishimaki, Yoko Takayama, Natsuo Yamamoto, Hiroyuki Kunishima, Mitsuo Kaku

Journal of Antimicrobial Chemotherapy　66　(3)　494-498　2011年3月

DOI： 10.1093/jac/dkq477 　

ISSN：0305-7453

eISSN：1460-2091

Endogenous secretory receptor for advanced glycation end products in non-small cell lung carcinoma 査読有り

Seiichi Kobayashi, Hiroshi Kubo, Takashi Suzuki, Kota Ishizawa, Mitsuhiro Yamada, Mei He, Yasuhiko Yamamoto, Hiroshi Yamamoto, Hironobu Sasano, Hidetada Sasaki, Satoshi Suzuki

American Journal of Respiratory and Critical Care Medicine　175　(2)　184-189　2007年

DOI： 10.1164/rccm.200602-212OC 　

ISSN：1073-449X

eISSN：1535-4970

Carbocisteine inhibits rhinovirus infection in human tracheal epithelial cells 査読有り

H. Yasuda, M. Yamaya, T. Sasaki, D. Inoue, K. Nakayama, M. Yamada, M. Asada, M. Yoshida, T. Suzuki, H. Nishimura, H. Sasaki

European Respiratory Journal　28　(1)　51-58　2006年7月

DOI： 10.1183/09031936.06.00058505 　

ISSN：0903-1936

Increased circulating endothelial progenitor cells in patients with bacterial pneumonia: Evidence that bone marrow derived cells contribute to lung repair 査読有り

M. Yamada, H. Kubo, K. Ishizawa, S. Kobayashi, M. Shinkawa, H. Sasaki

Thorax　60　(5)　410-413　2005年5月

DOI： 10.1136/thx.2004.034058 　

ISSN：0040-6376

The proton pump inhibitor lansoprazole inhibits rhinovirus infection in cultured human tracheal epithelial cells 査読有り

Takahiko Sasaki, Mutsuo Yamaya, Hiroyasu Yasuda, Daisuke Inoue, Mitsuhiro Yamada, Hiroshi Kubo, Hidekazu Nishimura, Hidetada Sasaki

European Journal of Pharmacology　509　(2-3)　201-210　2005年2月21日

DOI： 10.1016/j.ejphar.2004.12.042 　

ISSN：0014-2999

Acarbose attenuates hypoglycemia from dumping syndrome in an elderly man with gastrectomy [8] 査読有り

Mitsuhiro Yamada, Takashi Ohrui, Masanori Asada, Kota Ishizawa, Satoru Ebihara, Hiroyuki Arai, Hidetada Sasaki

Journal of the American Geriatrics Society　53　(2)　358-359　2005年2月

DOI： 10.1111/j.1532-5415.2005.53126_8.x 　

ISSN：0002-8614

eISSN：1532-5415

Hepatocyte growth factor induces angiogenesis in injured lungs through mobilizing endothelial progenitor cells 査読有り

Kota Ishizawa, Hiroshi Kubo, Mitsuhiro Yamada, Seiichi Kobayashi, Takashi Suzuki, Shinya Mizuno, Toshikazu Nakamura, Hidetada Sasaki

Biochemical and Biophysical Research Communications　324　(1)　276-280　2004年11月5日

DOI： 10.1016/j.bbrc.2004.09.049 　

ISSN：0006-291X

Interferon-γ: A key contributor to hyperoxia-induced lung injury in mice 査読有り

Mitsuhiro Yamada, Hiroshi Kubo, Seiichi Kobayashi, Kota Ishizawa, Hidetada Sasaki

American Journal of Physiology - Lung Cellular and Molecular Physiology　287　(5 31-5)　L1042-L1047　2004年11月

DOI： 10.1152/ajplung.00155.2004 　

ISSN：1040-0605

Survival rates between males and females 査読有り

T. Ohrui, M. Yamada, H. Kubo, H. Sasaki

Geriatrics and Gerontology International　4　(1)　68-70　2004年3月

DOI： 10.1111/j.1447-0594.2003.00104.x 　

ISSN：1444-1586

eISSN：1447-0594

Effect of gefitinib (ZD1839) on metastatic brain tumour [5] 査読有り

Hidenori Takahashi, Takashi Ohrui, Satoru Ebihara, Mitsuhiro Yamada, Hidetada Sasaki

Lung Cancer　43　(3)　371-372　2004年3月

DOI： 10.1016/j.lungcan.2003.09.017 　

ISSN：0169-5002

Bone Marrow-Derived Progenitor Cells Are Important for Lung Repair after Lipopolysaccharide-Induced Lung Injury 査読有り

Mitsuhiro Yamada, Hiroshi Kubo, Seiichi Kobayashi, Kota Ishizawa, Muneo Numasaki, Shinsaku Ueda, Takashi Suzuki, Hidetada Sasaki

Journal of Immunology　172　(2)　1266-1272　2004年1月15日

DOI： 10.4049/jimmunol.172.2.1266 　

ISSN：0022-1767

Bone marrow-derived cells contribute to lung regeneration after elastase-induced pulmonary emphysema 査読有り

Kota Ishizawa, Hiroshi Kubo, Mitsuhiro Yamada, Seiichi Kobayashi, Muneo Numasaki, Shinsaku Ueda, Takashi Suzuki, Hidetada Sasaki

FEBS Letters　556　(1-3)　249-252　2004年1月2日

DOI： 10.1016/S0014-5793(03)01399-1 　

ISSN：0014-5793

Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation 査読有り

Chikako Kanazawa, Eiji Morita, Mitsuhiro Yamada, Naoto Ishii, Shigeta Miura, Hironobu Asao, Tamostu Yoshimori, Kazuo Sugamura

Biochemical and Biophysical Research Communications　309　(4)　848-856　2003年10月3日

DOI： 10.1016/j.bbrc.2003.08.078 　

ISSN：0006-291X

Signal-transducing adaptor molecules STAM1 and STAM2 are required for T-cell development and survival 査読有り

Mitsuhiro Yamada, Naoto Ishii, Hironobu Asao, Kazuko Murata, Chieko Kanazawa, Hidetada Sasaki, Kazuo Sugamura

Molecular and Cellular Biology　22　(24)　8648-8658　2002年12月

DOI： 10.1128/MCB.22.24.8648-8658.2002 　

ISSN：0270-7306

Loss of hippocampal CA3 pyramidal neurons in mice lacking STAM1 査読有り

Mitsuhiro Yamada, Toshikazu Takeshita, Shigeto Miura, Kazuko Murata, Yutaka Kimura, Naoto Ishii, Masato Nose, Hiroyuki Sakagami, Hisatake Kondo, Fumi Tashiro, Jun Ichi Miyazaki, Hidetada Sasaki, Kazuo Sugamura

Molecular and Cellular Biology　21　(11)　3807-3819　2001年6月

DOI： 10.1128/MCB.21.11.3807-3819.2001 　

ISSN：0270-7306

Loss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice 査読有り

N. Ishii, Y. Owada, M. Yamada, S. Miura, K. Murata, H. Asao, H. Kondo, K. Sugamura

Molecular and Cellular Biology　21　(24)　8626-8637　2001年

DOI： 10.1128/MCB.21.24.8626-8637.2001 　

ISSN：0270-7306

STAM2, a new member of the STAM family, binding to the Janus kinases 査読有り

Kazuhiro Endo, Toshikazu Takeshita, Hirotake Kasai, Yoshiteru Sasaki, Nobuyuki Tanaka, Hironobu Asao, Kazu Kikuchi, Mitsuhiro Yamada, Min Chen, John J. O'Shea, Kazuo Sugamura

FEBS Letters　477　(1-2)　55-61　2000年7月14日

DOI： 10.1016/S0014-5793(00)01760-9 　

ISSN：0014-5793