研究者詳細

顔写真

キム　ヒヨンギ
金　鉉基
Hyeon-Ki Kim
所属
大学院医学系研究科　障害科学専攻　機能医科学講座（運動学分野）
職名
准教授
学位

  • 博士（スポーツ科学） （早稲田大学）

経歴 14

  • 2025年2月 ～ 継続中
    東北大学　大学院医学系研究科　准教授

  • 2024年10月 ～ 継続中
    国立研究開発法人医薬基盤・健康・栄養研究所　身体活動研究センター　客員研究員

  • 2024年4月 ～ 継続中
    広島大学　大学院医系科学研究科 公衆衛生学　客員研究員

  • 2024年10月 ～ 2025年1月
    東北大学　大学院医工学研究科　特任講師

  • 2023年4月 ～ 2024年9月
    国立研究開発法人医薬基盤・健康・栄養研究所　身体活動研究部　特任研究員

  • 2022年4月 ～ 2023年3月
    Hungarian University of Sports Science　Research Center for Molecular Exercise Science　Postdoctoral Researcher

  • 2022年4月 ～ 2023年3月
    早稲田大学　時間栄養学研究所　招聘研究員

  • 2021年5月 ～ 2023年3月
    慶應義塾大学　体育研究所　研究員

  • 2020年4月 ～ 2022年3月
    明治大学　情報コミュニケーション学部　非常勤講師

  • 2019年4月 ～ 2022年3月
    早稲田大学　先進理工学部　講師

  • 2017年3月 ～ 2020年3月
    港湾職業能力開発短期大学　港湾流通科、物流情報科　非常勤講師

  • 2017年4月 ～ 2019年3月
    早稲田大学　重点領域研究機構　研究助手

  • 2016年4月 ～ 2017年3月
    独立行政法人日本学術振興会　特別研究員（PD）

  • 2015年4月 ～ 2016年3月
    独立行政法人日本学術振興会　特別研究員（DC2）

︎全件表示 ︎最初の5件までを表示

学歴 2

  • 早稲田大学　大学院スポーツ科学研究科 スポーツ科学専攻 博士後期課程

    2012年9月 ～ 2016年3月

  • 早稲田大学　大学院スポーツ科学研究科 スポーツ科学専攻 修士課程

    2010年4月 ～ 2012年3月

委員歴 2

  • 大韓ヒューマンムーブメント学会　編集委員

    2019年3月 ～ 継続中

  • 港区学校教育食育推進計画検討委員会　委員

    2018年11月 ～ 2022年3月

所属学協会 3

  • 大韓ヒューマンムーブメント学会

  • 日本時間栄養学会

  • 日本体力医学会

研究キーワード 5

  • 時間栄養学

  • 応用健康科学

  • 運動生理学

  • 身体活動

  • 時間運動学

研究分野 2

  • ライフサイエンス / スポーツ科学 /

  • ライフサイエンス / 栄養学、健康科学 /

受賞 5

  1. Editor’s Choice

    2024年5月　Metabolites　Relationship between Fasting and Postprandial Glucose Levels and the Gut Microbiota

  2. 2023年度 公益信託 タニタ健康体重基金

    2023年10月

  3. 韓国を輝かせる人々

    2021年7月　韓国国立生物科学研究情報センター

  4. 優秀論文賞

    2020年　日本臨床生理学会　Substrate Metabolism Responses to Equicaloric Exercise at the Maximal Fat Oxidation Intensity or High Intensity in Endurance-trained Men

  5. 優秀論文賞

    2014年　日本臨床生理学会　The difference of the influence between acute swimming and running on cardiac fatigue in young male

論文 49

  1. Intrinsic exercise capacity is associated with skeletal muscle clock gene and IGF-1 signaling in aged low- and high-running capacity rats 査読有り

    Hyeon-Ki Kim, Takuji Kawamura, Zoltan Bori, Lauren Gerard Koch, Steven Loyal Britton, Zsolt Radak

    Frontiers in Physiology　17　2026年6月9日

    出版者・発行元： Frontiers Media SA

    DOI： 10.3389/fphys.2026.1818866 　

    eISSN：1664-042X

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    Background Intrinsic exercise capacity is a strong predictor of health and longevity and is independently associated with aging- and disease-related outcomes. Although previous studies using low- and high-capacity runner (LCR and HCR) rats have demonstrated organ-specific patterns of epigenetic aging, the molecular mechanisms linking intrinsic aerobic capacity to skeletal muscle signaling remain incompletely understood. Objective This study investigated whether intrinsic exercise capacity is associated with alterations in skeletal muscle clock gene expression and insulin-like growth factor-1 (IGF-1)–related signaling pathways. Methods Female LCR and HCR rats (23–24 months old, 44th generation) underwent maximal oxygen uptake (VO 2 max) testing, followed by molecular analyses of plantaris and soleus muscles using quantitative PCR and Western blotting. Results VO 2 max was significantly higher in HCR rats. In skeletal muscle, LCR rats exhibited higher mRNA expression levels of Cry1, Bmal1, Igf1, and Igf1Ec measured at ZT2–ZT3, whereas expression of Cry2, Pdk4, and MuRF-1 did not differ between phenotypes. Despite increased Igf1 expression in LCR rats, the phosphorylated-to-total JAK2 ratio was reduced, while STAT5 phosphorylation was unchanged. Correlation analyses demonstrated significant negative associations between VO 2 max and Igf1 , Igf1Ec , Cry1 , and Bmal1 expression. Conclusion These findings indicate that low intrinsic exercise capacity is associated with coordinated alterations in skeletal muscle clock gene expression and IGF-1– related signaling, suggesting altered IGF-1–related signaling balance in aging skeletal muscle. These results provide mechanistic insight into how intrinsic aerobic capacity may influence muscle biology and health trajectories during aging.

  2. Hydration, water requirements, and energy balance from spring to summer in free-living older adults: a doubly labelled water study 査読有り

    Hyeon-Ki Kim, Yui Nakayama, Tsukasa Yoshida, Keiichi Yokoyama, Yuya Watanabe, Aya Itoi, Eiichi Yoshimura, Hinako Nanri, Rie Tsutsumi, Yumi Nakamura, Norifumi Tateishi, Rei Ono, Misaka Kimura, Hiroyuki Sagayama, Yosuke Yamada, Yasuko Yoshinaka, Mie Yoshimoto, Yoko Tanaka, Emi Yamagata, Naoyuki Ebine, Kazuko Ishikawa-Takata, Motoko Miyake, Taeko Masumoto, Yasuko Okayama, Miho Nishimura, Hajime Tamiya, Tomoki Nakaya, Minoru Yamada, Hidenori Arai, Mitsuyoshi Yoshida, Takeshi Kikutani, Date Heiwa

    Scientific Reports　2026年2月19日

    出版者・発行元： Springer Science and Business Media LLC

    DOI： 10.1038/s41598-026-38832-w 　

    eISSN：2045-2322

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    Abstract The escalating effects of climate change, particularly global warming, are posing an increasing burden on human health. Older adults are particularly susceptible to the impact of extreme heat. Adequate water intake is essential to prevent dehydration in hot environments. Therefore, it is important to understand water turnover (WT) and intake. WT of older adults in hot environments remains unknown. This study aimed at investigating the seasonal effects on WT, total energy expenditure (TEE), and physical activity using doubly labeled water (DLW) and a triaxial accelerometer. A total of 26 older Japanese adult males and females aged ≥ 65 years participated in the study. WT and TEE were measured using DLW in May and August 2012. The mean values of maximum, mean, and minimum temperatures and mean humidity of the measurement days were 24 °C, 19 °C, 14 °C, and 57% in May (spring) and 35 °C, 29 °C, 25 °C, and 66% in August (summer) 2012, respectively. The mean (standard deviation, SD) age of the participants was 73.7 (5.4) years. Total body water increased significantly from 31.1 (4.6) to 31.9 (5.2) kg (+ 0.8 kg, P  = 0.009) from May to August. TEE decreased significantly from 2271 (280) to 2123 (470) kcal/day (- 149 kcal/d, P  = 0.036), while WT increased significantly from 2.939 (0.625) to 3.579 (0.943) L/day (+ 0.640 L/d, P  < 0.001). WT increased by 640 mL/day during summer compared to that during spring, when the average temperature was 19 °C. Our findings indicate that WT increases during hot weather in older adults, reflecting seasonal adaptation.

  3. Prevalence of Frailty in Community-Dwelling Adults Aged 18–99 Years: Design and Demographics of the Osaka-Settsu Prospective Cohort Study for Health, Nutrition and Well-being (Preprint) 査読有り

    Mikako Yasuoka, Hyeon-Ki Kim, Tsukasa Yoshida, Kan Oishi, Chiharu Iwasaka, Takashi Nakagata, Yui Nakayama, Hinako Nanri, Eiichi Yoshimura, Yoichi Hatamoto, Yuka Hamada, Nobuaki Moriyama, Mai Matsumoto, Ikuko Kashino, Miwa Yamaguchi, Nobuyo Tsuboyama-Kasaoka, Moeka Harada, Mieko Nakamura, Haruka Shibata, Heiwa Date, Misaka Kimura, Ken Sugimoto, Motohiko Miyachi, Tomoki Nakaya, Yuri Miyamoto, Ryota Akagi, Haruhisa Fukuda, Shigeru Inoue, Mitsuyoshi Yoshida, Takeshi Kikutani, Masafumi Ihara, Kazuki Fukuma, Hiroshi Murayama, Yoshinori Fujiwara, Shosuke Satake, Hidenori Arai, Haruki Momma, Yosuke Yamada, Rei Ono, Hidemi Takimoto

    2025年12月30日

    DOI： 10.2196/preprints.90538 　

  4. Association of physical activity and hydration markers with cellular health in older adults: A doubly labeled water study 査読有り

    Kan Oishi, Tsukasa Yoshida, Hyeon-Ki Kim, Keiichi Yokoyama, Yuya Watanabe, Yui Nakayama, Misaka Kimura, Kojiro Ishii, Rei Ono, Yosuke Yamada

    Experimental Gerontology　112859-112859　2025年8月

    出版者・発行元： Elsevier BV

    DOI： 10.1016/j.exger.2025.112859 　

    ISSN：0531-5565

  5. 運動習慣で層別化した体格とフレイルの関連 摂津スタディ

    吉田 司, 安岡 実佳子, 金 鉉基, 澤田 奈緒美, 南里 妃名子, 岩坂 知治, 中潟 崇, 郡山 さくら, 山田 陽介, 小野 玲

    日本老年医学会雑誌　62　(Suppl.)　204-204　2025年5月

    出版者・発行元： (一社)日本老年医学会

    ISSN：0300-9173

  6. Morning physical activity may be more beneficial for blood lipids than afternoon physical activity in older adults: a cross-sectional study 査読有り

    Hyeon-Ki Kim, Yuga Kimura, Masaki Takahashi, Takashi Nakaoka, Yosuke Yamada, Rei Ono, Shigenobu Shibata

    European Journal of Applied Physiology　2024年6月14日

    出版者・発行元： Springer Science and Business Media LLC

    DOI： 10.1007/s00421-024-05526-y 　

    ISSN：1439-6319

    eISSN：1439-6327

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    Abstract Background The effect of differences in daily physical activity patterns on blood lipids has not been determined. This study examines the effects of the differences in free-living daily physical activity patterns (amount and intensity) on blood lipid levels in older adults. Methods This cross-sectional study included 51 older participants (71.8 ± 0.6 years, men = 8, women = 43). A triaxial accelerometer was used to assess physical activity patterns. The time from awakening to bedtime for each participant was used for group classification based on the amount (number of steps) and intensity (moderate-to-vigorous physical activity, MVPA) of physical activity. The morning step group (M Step) was defined as those who took more steps in the morning, and the afternoon step group (A Step) was defined as those who took more steps in the afternoon. The same method was used for MVPA (morning MVPA: M MVPA; afternoon MVPA: A MVPA). Blood samples were collected at the start of the study to determine blood lipid levels. Results Number of steps taken showed a trend toward lower low-density lipoprotein cholesterol (LDL-C) levels in the M Step group compared with the A Step group. The LDL/high-density lipoprotein (HDL) ratio was significantly lower in the M Step group than the A Step group (p < 0.05). The M MVPA group also had higher HDL-C levels and significantly lower LDL/HDL ratios than the A MVPA group (p < 0.05). Conclusions These results suggest that compared with afternoon physical activity, daily morning physical activity (amount and intensity) is more effective in improving blood lipid levels.

  7. Predictors of Water Turnover in Older Adults: A Doubly Labeled Water- and Triaxial Accelerometer-Based Study 査読有り

    Hyeon-Ki Kim, Hiroyuki Sagayama, Tsukasa Yoshida, Kan Oishi, Yui Nakayama, Misaka Kimura, Rei Ono, Yosuke Yamada

    The Journal of Nutrition　154　(6)　1750-1757　2024年4月

    出版者・発行元： Elsevier BV

    DOI： 10.1016/j.tjnut.2024.04.023 　

    ISSN：0022-3166

  8. Relationship between changes in muscle stiffness after a comfortable massage and the massage pressure 査読有り

    Takayuki Inami, Shota Yamaguchi, Hyeon-Ki Kim, Hirofumi Miyagawa, Mitsuyoshi Murayama

    Journal of Bodywork and Movement Therapies　2024年3月

    出版者・発行元： Elsevier BV

    DOI： 10.1016/j.jbmt.2024.03.025 　

    ISSN：1360-8592

  9. Association between disruption of circadian activity rhythms and obesity 査読有り

    Hyeon-Ki Kim, Yosuke Yamada, Yu Tahara, Masaki Takahashi, Rei Ono, Shigenobu Shibata

    Chronobiology International　1-11　2023年11月22日

    出版者・発行元： Informa UK Limited

    DOI： 10.1080/07420528.2023.2285314 　

    ISSN：0742-0528

    eISSN：1525-6073

  10. Association between circadian clock gene expressions and meal timing in young and older adults. 国際誌 査読有り

    Masaki Takahashi, Mayuko Fukazawa, Yu Tahara, Hyeon-Ki Kim, Kumpei Tanisawa, Tomoko Ito, Takashi Nakaoka, Mitsuru Higuchi, Shigenobu Shibata

    Chronobiology international　1-9　2023年9月18日

    DOI： 10.1080/07420528.2023.2256855 　

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    Ageing is associated with a decline in circadian clock systems, which correlates with the development of ageing-associated diseases. Chrononutrition is a field of chronobiology that examines the relationship between the timing of meal/nutrition and circadian clock systems. Although there is growing evidence regarding the role of chrononutrition in the prevention of lifestyle and ageing-related diseases, the optimal timing of meal intake to regulate the circadian clock in humans remains unknown. In this study, we investigated the relationship between clock gene expression and meal timing in young and older adults. In this cross-sectional study, we enrolled 51 healthy young men and 35 healthy older men (age, mean±standard deviation: 24 ± 4 and 70 ± 4 y, respectively). Under daily living conditions, beard follicle cells were collected at 4-h intervals over a 24-h period to evaluate clock gene expression. Participants were asked to record the timing of habitual sleep and wake-up, breakfast, lunch, and dinner. From these data, we calculated "From bedtime to breakfast time," "From wake up to first meal time," and "From dinner to bed time." NR1D1 and PER3 expressions in older adults at 06:00 h were significantly higher than those in young adults (P = 0.001). There were significant differences in the peak time for NR1D2 (P = 0.003) and PER3 (P = 0.049) expression between young and older adults. "From bedtime to breakfast time" was significantly longer in older adults than in young adults. In contrast, "From dinner to bed time" was significantly shorter in older adults than in young adults. Moreover, higher rhythmicity of NR1D1 correlated with longer "From bedtime to breakfast time" (r =  -0.470, P = 0.002) and shorter "From wake up to first meal time" in young adults (r = 0.302, P = 0.032). Higher rhythmicity of PER3 correlated with longer "From bedtime to breakfast time" in older adults (r =  -0.342, P = 0.045). These results suggest that the peak time of clock gene expression in older adults may be phase-advanced compared to that in young adults. In addition, a longer fasting duration from bedtime to breakfast in both young and older adults and earlier intake of meals after waking up in young adults may correlate with robust clock gene expression rhythms.

  11. Associations between cardiorespiratory fitness and lifestyle‐related factors with DNA methylation‐based ageing clocks in older men: WASEDA'S Health Study 査読有り

    Takuji Kawamura, Zsolt Radak, Hiroki Tabata, Hiroshi Akiyama, Nobuhiro Nakamura, Ryoko Kawakami, Tomoko Ito, Chiyoko Usui, Matyas Jokai, Ferenc Torma, Hyeon‐Ki Kim, Motohiko Miyachi, Suguru Torii, Katsuhiko Suzuki, Kaori Ishii, Shizuo Sakamoto, Koichiro Oka, Mitsuru Higuchi, Isao Muraoka, Kristen M. McGreevy, Steve Horvath, Kumpei Tanisawa

    Aging Cell　2023年8月16日

    出版者・発行元： Wiley

    DOI： 10.1111/acel.13960 　

    ISSN：1474-9718

    eISSN：1474-9726

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    Abstract DNA methylation‐based age estimators (DNAm ageing clocks) are currently one of the most promising biomarkers for predicting biological age. However, the relationships between cardiorespiratory fitness (CRF), measured directly by expiratory gas analysis, and DNAm ageing clocks are largely unknown. We investigated the relationships between CRF and the age‐adjusted value from the residuals of the regression of DNAm ageing clock to chronological age (DNAmAgeAcceleration: DNAmAgeAccel) and attempted to determine the relative contribution of CRF to DNAmAgeAccel in the presence of other lifestyle factors. DNA samples from 144 Japanese men aged 65–72 years were used to appraise first‐ (i.e., DNAmHorvath and DNAmHannum) and second‐ (i.e., DNAmPhenoAge, DNAmGrimAge, and DNAmFitAge) generation DNAm ageing clocks. Various surveys and measurements were conducted, including physical fitness, body composition, blood biochemical parameters, nutrient intake, smoking, alcohol consumption, disease status, sleep status, and chronotype. Both oxygen uptake at ventilatory threshold (VO2/kg at VT) and peak oxygen uptake (VO2/kg at Peak) showed a significant negative correlation with GrimAgeAccel, even after adjustments for chronological age and smoking and drinking status. Notably, VO2/kg at VT and VO2/kg at Peak above the reference value were also associated with delayed GrimAgeAccel. Multiple regression analysis showed that calf circumference, serum triglyceride, carbohydrate intake, and smoking status, rather than CRF, contributed more to GrimAgeAccel and FitAgeAccel. In conclusion, although the contribution of CRF to GrimAgeAccel and FitAgeAccel is relatively low compared to lifestyle‐related factors such as smoking, the results suggest that the maintenance of CRF is associated with delayed biological ageing in older men.

  12. Localized-bioelectrical impedance vector analysis on mechanical property changes after muscle injury and damage 査読有り

    Takayuki INAMI, Shota YAMAGUCHI, Hyeon-Ki KIM, Mitsuyoshi MURAYAMA

    The Journal of Sports Medicine and Physical Fitness　63　(3)　2023年3月

    出版者・発行元： Edizioni Minerva Medica

    DOI： 10.23736/s0022-4707.22.14416-6 　

    ISSN：0022-4707

    eISSN：1827-1928

  13. Effects of the timing of acute mulberry leaf extract intake on postprandial glucose metabolism in healthy adults: a randomised, placebo-controlled, double-blind study 国際誌 査読有り

    Masaki Takahashi, Yui Mineshita, Jumpei Yamagami, Chunyi Wang, Kyoko Fujihira, Yu Tahara, Hyeon-Ki Kim, Takashi Nakaoka, Shigenobu Shibata

    European Journal of Clinical Nutrition　77　(4)　468-473　2023年1月17日

    出版者・発行元： Springer Science and Business Media LLC

    DOI： 10.1038/s41430-023-01259-x 　

    ISSN：0954-3007

    eISSN：1476-5640

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    Abstract Background/Objectives Glucose tolerance is controlled by the internal clock and is worse in the evening. From a chrononutrition perspective, diabetes prevention requires evaluating the antidiabetic effects of the timing of functional ingredients and nutrient intake. The purpose of this study was to investigate the timing effects of acute mulberry leaf extract (MLE) intake on postprandial glucose levels in young adults. Subjects/Methods Twelve young adults underwent four trials. Blood samples were collected in a fasting state and at 30, 60, 120, and 180 min after eating a mixed meal. The study had a randomised, placebo-controlled, double-blind trial design involving: (1) morning placebo trial (08:00 h; MP trial), (2) evening placebo trial (18:00 h; EP trial), (3) morning MLE trial (08:00 h; MM trial), and (4) evening MLE trial (18:00 h; EM trial). Results The incremental area under the blood glucose curve (iAUC) in the EM trials was significantly lower than that in the EP trials (P = 0.010). The postprandial glucose concentrations 120 min after the meal were significantly lower in the EM trials than those in the EP trials (P = 0.006). The postprandial insulin concentrations at 120 min were significantly lower in the MM trials than those in the MP trials (P = 0.034). Moreover, the postprandial insulin concentrations 180 min after the meal were significantly lower in the EM trials than those in the EP trials (P = 0.034). Conclusions MLE intake in the evening, but not in the morning, was effective in improving glucose tolerance. Trial registration Clinical trial reference: UMIN 000045301; website of trial registry: https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000051340.

  14. Chrono-exercise: Time-of-day-dependent physiological responses to exercise 査読有り

    Hyeon-Ki Kim, Zsolt Radak, Masaki Takahashi, Takayuki Inami, Shigenobu Shibata

    Sports Medicine and Health Science　2022年11月30日

    出版者・発行元： Elsevier BV

    DOI： 10.1016/j.smhs.2022.11.003 　

    ISSN：2666-3376

  15. Effect of lunch with different calorie and nutrient balances on dinner-induced postprandial glucose variability 査読有り

    Mai Kuwahara, Hyeon-Ki Kim, Akiko Furutani, Yui Mineshita, Takashi Nakaoka, Shigenobu Shibata

    Nutrition & Metabolism　19　(1)　2022年9月24日

    出版者・発行元： Springer Science and Business Media LLC

    DOI： 10.1186/s12986-022-00704-1 　

    ISSN：1743-7075

    eISSN：1743-7075

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    Abstract Aim This study aimed to examine the effect of lunches with different caloric contents (Study 1) and nutrient balances (Study 2) on dinner-induced postprandial glucose fluctuation. Methods Energy trial (Study 1): Thirteen healthy young participants (n = 10 men, n = 3 women) were investigated to determine the effects of different caloric intakes at lunch on glucose level variability. The study was comprised of four trials (no lunch, low lunch, standard lunch, and high-energy lunch). Energy balance trial (Study 2): Fourteen healthy young adults (n = 8 men, n = 6 women) were investigated to determine the effect of different nutrient balances during lunch on glucose level variability. The study consisted of four trials (standard, protein-rich, fat-rich, and carbohydrate-rich). In studies 1 and 2, each trial was spaced at least 24 full hours apart, and breakfast and dinner were tested as meals. The mealtimes for each trial were then aligned. Continuous glucose monitoring was used to assess the blood glucose fluctuations. Results Study 1: The no-lunch (95% CI 95.5–149.7) and low-energy lunch (95% CI 90.8–143.1) trials had significantly higher values in the incremental area under the curve (iAUC) of postprandial blood glucose at dinner compared to the standard (95% CI 55.4–90.0) and high-energy lunch (95% CI 29.3–54.6) trials (P = 0.006, P = 0.001 vs. none), (P = 0.004, P = 0.001 vs. low-energy trial). Study 2: A significantly higher postprandial blood glucose iAUC for dinner was found in the fat-rich trial (95% CI 58.5–114.0) than that in the protein-rich (95% CI 25.6–63.9) and standard (95% CI 25.6–112.4) trials, (P = 0.006, P = 0.035 vs. fat-rich trial). Conclusions Our findings indicate that skipping lunch and low-calorie or high-lipid intake increased postprandial blood glucose levels after dinner.

  16. Late-afternoon endurance exercise is more effective than morning endurance exercise at improving 24-h glucose and blood lipid levels 査読有り

    Hyeon-Ki Kim, Shota Furuhashi, Masaki Takahashi, Hanako Chijiki, Takuya Nanba, Takayuki Inami, Zsolt Radak, Shizuo Sakamoto, Shigenobu Shibata

    Frontiers in Endocrinology　13　2022年7月19日

    出版者・発行元： Frontiers Media SA

    DOI： 10.3389/fendo.2022.957239 　

    ISSN：1664-2392

    eISSN：1664-2392

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    Background Glucose and lipid tolerance reportedly exhibit diurnal variations, being lower in the evening than in the morning. Therefore, the effects of exercise on glucose and blood lipid levels at different times of the day may differ. This study aimed to investigate the effects of short-term endurance exercise intervention in the morning versus late afternoon on 24-h blood glucose variability and blood lipid levels. Methods Twelve healthy young men participated in a randomized crossover trial. The participants were assigned to morning (09:00–11:00) or late afternoon (16:00–18:00) endurance exercise for a week, consisting of supervised exercise sessions on Mondays, Wednesdays, and Fridays. In the morning and evening trials, the participants walked for 60 min on a treadmill at approximately 60% of maximal oxygen uptake (VO2max). Following a 2-week wash-out period, the participants performed the exercise training regimen at another time point. Continuous glucose monitoring was used to evaluate blood glucose fluctuations during each 24-h trial period. Blood samples were collected before and after each intervention to examine blood lipid and hormonal responses. Results Examination of the area under the curve (AUC) of the glucose level changes for 24 h after the late afternoon versus morning exercise intervention revealed significantly lower values for the former versus the latter (P < 0.01). The AUC of glucose level changes after each meal was also lower after the late afternoon versus morning intervention, and significantly lower values were observed in the late afternoon versus morning trial for breakfast and dinner (P < 0.05, P < 0.01). In addition, a significant decrease in triglycerides (TG) and TG/high-density lipoprotein cholesterol (HDL-C) was noted after versus before the late afternoon intervention (P < 0.05). Conclusions These results suggest that late afternoon endurance exercise is more effective than morning endurance exercise at improving 24-h glucose and triglyceride levels.

  17. Relationship between Fasting and Postprandial Glucose Levels and the Gut Microbiota 査読有り

    Yui Mineshita, Hiroyuki Sasaki, Hyeon-Ki Kim, Shigenobu Shibata

    Metabolites　12　(7)　669　2022年7月

    DOI： 10.3390/metabo12070669 　

    ISSN：2218-1989

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    <jats:p>Postprandial hyperglycemia increases the risk of mortality among patients with type 2 diabetes and cardiovascular diseases. Additionally, the gut microbiota and type 2 diabetes and cardio-vascular disease are known to be correlated. Currently, fasting blood glucose is the primary in-dex for the clinical diagnosis of diabetes; however, postprandial blood glucose is associated with the risk of developing type 2 diabetes and cardiovascular disease and mortality. Therefore, the dynamic change in blood glucose levels under free-living conditions is considered an important and better marker than fasting glucose levels to study the relationship between glucose levels and microbiota. Here, we investigated the relationship between fasting and postprandial glucose levels and microbiota under free-living conditions for one week in older adults. In addition, in order to clarify the relationship between blood glucose level and intestinal bacteria, postprandial 4-h AUC was calculated and the correlation with gut bacteria was investigated. As a result of the present study, we observed many of the most significant correlations between the gut bacteria and the peak glucose levels after dinner and the 4-h AUC after dinner. Together, these findings suggest that the individual pattern of microbiota may help to predict post-dinner hyperglycemia and the risk of abnormal glucose metabolism, such as diabetes.</jats:p>

  18. 女性高齢者における身体活動の増加が血中脂質および血圧に及ぼす影響 査読有り

    金 鉉基, 田端宏樹, 小西真幸, 坂本静男

    日本臨床スポーツ医学会誌　30　(1)　148-156　2022年1月

  19. Supplementation of Protein at Breakfast Rather Than at Dinner and Lunch Is Effective on Skeletal Muscle Mass in Older Adults 国際誌 査読有り

    Hyeon-Ki Kim, Hanako Chijiki, Mayuko Fukazawa, Jin Okubo, Mamiho Ozaki, Takuya Nanba, Seiichirou Higashi, Miho Shioyama, Masaki Takahashi, Takashi Nakaoka, Shigenobu Shibata

    Frontiers in Nutrition　8　797004-797004　2021年12月21日

    出版者・発行元： Frontiers Media SA

    DOI： 10.3389/fnut.2021.797004 　

    eISSN：2296-861X

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    <bold>Background:</bold> The effects of different intake patterns of meal protein on muscle mass have not been clarified. We cross-sectionally and longitudinally examined the effect of different timing of protein intake on sarcopenia-related factors in older adults. <bold>Methods:</bold> This cross-sectional study 1 included 219 (male, <italic>n</italic> = 69, female, <italic>n</italic> = 150) elderly subjects aged ≥65 years. Subjects who consumed more protein at breakfast than at dinner were grouped into the morning group (MG, <italic>n</italic> = 76; male, <italic>n</italic> = 26; female, <italic>n</italic> = 50), and those who consumed more protein at dinner than at breakfast were grouped into the evening group (EG, <italic>n</italic> = 143; male, <italic>n</italic> = 43; female, <italic>n</italic> = 100). In cross-sectional study 2-1 (female, <italic>n</italic> = 125), the subjects were classified into four groups according to the number of meals with sufficient protein intake. In cross-sectional studies 2-2 (female, <italic>n</italic> = 125) and 2-3 (female, <italic>n</italic> = 27), the subjects were classified into eight groups and three groups according to whether they had consumed sufficient protein at three meals; sarcopenia-related factors were compared. The intervention study was a placebo-controlled, double-blind, randomized controlled trial that included 40 elderly women with low daily breakfast protein intake. The subjects were divided into four groups: morning protein and placebo intake groups and evening protein and placebo intake groups. Each group consumed the test food (containing 10 g milk protein) or placebo in the morning or evening for 12 weeks. Blood indices and physical function were assessed before and after the intervention. <bold>Results:</bold> Comparing all subjects, MG showed significantly higher handgrip strength than did EG (<italic>P</italic> &amp;lt; 0.05). The higher ratio of morning protein intake relative to the total protein intake, the better the muscle mass (<italic>r</italic> = 0.452, <italic>P</italic> &amp;lt; 0.05) and handgrip strength (<italic>r</italic> = 0.383, <italic>P</italic> &amp;lt; 0.05). The intervention study showed an increase in muscle mass with the intake of milk protein in the morning rather than in the evening (<italic>P</italic> &amp;lt; 0.05). <bold>Conclusions:</bold> Protein intake at breakfast might have relatively stronger effects on skeletal muscle mass than at lunch and dinner.

  20. Attending a Sports Club Can Help Prevent Visual Impairment Caused by Cram School in Elementary School Children in Japan 国際誌 査読有り

    Yui Mineshita, Hyeon-Ki Kim, Takae Shinto, Mai Kuwahara, Shigenobu Shibata

    International Journal of Environmental Research and Public Health　18　(23)　12440-12440　2021年11月26日

    出版者・発行元： MDPI AG

    DOI： 10.3390/ijerph182312440 　

    eISSN：1660-4601

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    Longer durations for near-work activities, such as studying, worsen eyesight. In contrast, outdoor exercise is effective in reducing the risk of developing myopia. Despite these findings, however, the interaction between studying and exercise in eyesight has not been quantitatively evaluated. Moreover, since there is a culture of attending lessons in Japan, it is important to investigate the relationship between elementary school activities, such as cram schools or sports clubs, and vision. Therefore, in this study, we examined whether attending cram schools and/or sports clubs is associated with the use of glasses among elementary school students. We conducted a survey among 7419 elementary school students in Tokyo, Japan using a food education questionnaire. A logistic regression analysis was used to evaluate the relationship between wearing glasses, an objective variable, and attending sports clubs and cram schools. Sex and school year were considered confounding factors. The results of this study showed that students who attended only sports clubs were more likely to be categorized into the “not wearing glasses” group (p = 0.03, OR = 1.45), whereas those who attended only cram schools were more likely to be categorized into the “wearing glasses” group (p = 0.008, OR = 0.67). In addition, students who attended both cram schools and sports clubs were more likely to be categorized into the “not wearing glasses” group than those who only attended cram schools (p = 0.28, OR = 0.85). Our findings indicate that attending not only cram schools but also sports clubs may prevent deterioration of eyesight. Parents and health care providers need to take these findings into account in order to prevent visual impairment in children.

  21. Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock 国際誌 査読有り

    Shinya Aoyama, Hyeon-Ki Kim, Rina Hirooka, Mizuho Tanaka, Takeru Shimoda, Hanako Chijiki, Shuichi Kojima, Keisuke Sasaki, Kengo Takahashi, Saneyuki Makino, Miku Takizawa, Masaki Takahashi, Yu Tahara, Shigeki Shimba, Kazuyuki Shinohara, Shigenobu Shibata

    Cell Reports　36　(1)　109336-109336　2021年7月

    出版者・発行元： Elsevier BV

    DOI： 10.1016/j.celrep.2021.109336 　

    ISSN：2211-1247

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    The meal distribution of proteins throughout the day is usually skewed. However, its physiological implications and the effects of better protein distribution on muscle volume are largely unknown. Here, using the two-meals-per-day feeding model, we find that protein intake at the early active phase promotes overloading-induced muscle hypertrophy, in a manner dependent on the local muscle clock. Mice fed branched-chain amino acid (BCAA)-supplemented diets at the early active phase demonstrate skeletal muscle hypertrophy. However, distribution-dependent effects are not observed in ClockΔ19 or muscle-specific Bmal1 knockout mice. Additionally, we examined the relationship between the distribution of proteins in meals and muscle functions, such as skeletal muscle index and grip strength in humans. Higher muscle functions were observed in subjects who ingested dietary proteins mainly at breakfast than at dinner. These data suggest that protein intake at breakfast may be better for the maintenance of skeletal muscle mass.

  22. 朝のスケトウダラの速筋タンパクの摂取が高齢者の骨格筋量および筋力に及ぼす影響 査読有り

    金 鉉基、難波拓哉、千々木華子、深澤真由子、大久保仁、尾﨑真実帆、内田健志、加藤綾華、田中紀雄、鳴海誠、中岡隆志、柴田重信

    薬理と治療　49　(5)　747-756　2021年5月

  23. Screen Time Duration and Timing: Effects on Obesity, Physical Activity, Dry Eyes, and Learning Ability in Elementary School Children 国際誌 査読有り

    Yui Mineshita, Hyeon-Ki Kim, Hanako Chijiki, Takuya Nanba, Takae Shinto, Shota Furuhashi, Satoshi Oneda, Mai Kuwahara, Anzu Suwama, Shigenobu Shibata

    BMC public health　21　(1)　422-422　2021年2月

    出版者・発行元： Research Square

    DOI： 10.21203/rs.3.rs-80923/v1 　

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    <title>Abstract</title> <bold>Background: </bold>As internet use becomes more widespread, the screen time (ST) of elementary school students increases yearly. It is known that longer durations of ST can affect obesity, physical activity, dry eye disease, and learning ability. However, the effects of ST just before bedtime have not been clarified. Therefore, we examined ST duration and timing effects on elementary school children. <bold>Methods: </bold>We conducted a survey of 7,419 elementary school students in Tokyo, Japan using a questionnaire on food education. ST duration and timing (just before bedtime) served as the explanatory variables, and the relationship between obesity, physical activity, dry eyes, and learning ability was analyzed using logistic regression analysis. Gender, school year, height, and weight were considered confounding factors. First, we examined whether ST duration and timing were related to each objective variable, using a univariate model to examine all variables. Thereafter, we performed multivariate logistic regression analyses for all variables showing a significant difference in the univariate models.<bold>Results:</bold> The results showed that the relationship between the ST duration and obesity, physical activity, and learning ability was statistically significant. The relationship between ST timing and obesity, dry eyes, and learning ability was also statistically significant. Therefore, ST timing has a greater effect on dry eyes, and ST duration has a greater effect on academic performance. <bold>Conclusion: </bold>Our findings indicate that ST in school children is related to obesity, physical activity, dry eyes, and learning ability, and they suggest that not only the duration but also the timing of ST is important.

  24. Ingestion of Helianthus tuberosus at Breakfast Rather Than at Dinner is More Effective for Suppressing Glucose Levels and Improving the Intestinal Microbiota in Older Adults 国際誌 査読有り

    Hyeon-Ki Kim, Hanako Chijiki, Takuya Nanba, Mamiho Ozaki, Hiroyuki Sasaki, Masaki Takahashi, Shigenobu Shibata

    NUTRIENTS　12　(10)　2020年10月

    DOI： 10.3390/nu12103035 　

    eISSN：2072-6643

  25. Effect of the Intake of a Snack Containing Dietary Fiber on Postprandial Glucose Levels 国際誌 査読有り

    Hyeon-Ki Kim, Takuya Nanba, Mamiho Ozaki, Hanako Chijiki, Masaki Takahashi, Mayuko Fukazawa, Jin Okubo, Shigenobu Shibata

    FOODS　9　(10)　2020年10月

    DOI： 10.3390/foods9101500 　

    eISSN：2304-8158

  26. Consumption of Biscuits with a Beverage of Mulberry or Barley Leaves in the Afternoon Prevents Dinner-Induced High, but Not Low, Increases in Blood Glucose among Young Adults 国際誌 査読有り

    Mai Kuwahara, Hyeon-Ki Kim, Mamiho Ozaki, Takuya Nanba, Hanako Chijiki, Mayuko Fukazawa, Jin Okubo, Yui Mineshita, Masaki Takahashi, Shigenobu Shibata

    NUTRIENTS　12　(6)　2020年6月

    DOI： 10.3390/nu12061580 　

    eISSN：2072-6643

  27. Effects of Timing of Acute and Consecutive Catechin Ingestion on Postprandial Glucose Metabolism in Mice and Humans 国際誌 査読有り

    Masaki Takahashi, Mamiho Ozaki, Miku Tsubosaka, Hyeon-Ki Kim, Hiroyuki Sasaki, Yuji Matsui, Masanobu Hibi, Noriko Osaki, Masashi Miyashita, Shigenobu Shibata

    NUTRIENTS　12　(2)　2020年2月

    DOI： 10.3390/nu12020565 　

    eISSN：2072-6643

  28. When and How Should Chinese Pregnant Women Exercise? A Longitudinal Study in China 国際誌 査読有り

    Mi Xiang, Masayuki Konishi, Huanhuan Hu, Mio Nishimaki, Hyeon-Ki Kim, Hiroki Tabata, Hisao Shimizu, Yue Fang, Xueyuan Li, Jiawei Xu, Zhiruo Zhang, Huigang Liang, Takashi Arao, Shizuo Sakamoto

    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH　17　(1)　2020年1月

    DOI： 10.3390/ijerph17010180 　

    eISSN：1660-4601

  29. Substrate Metabolism Responses to Equicaloric Exercise at the Maximal Fat Oxidation Intensity or High Intensity in Endurance-trained Men 査読有り

    Hiroki TABATA, Hyeon-ki KIM, Masayuki KONISHI, Naoya ENDO, Shizuo SAKAMOTO

    Journal of Clinical Physiology　49　(5)　191-200　2019年12月

    DOI： 10.34363/jocp.49.5_191 　

    ISSN：0286-7052 2435-1695

  30. Physical activity and dietary intake among Chinese pregnant women: an observational study 国際誌 査読有り

    Mi Xiang, Jing Zhang, Huigang Liang, Zhiruo Zhang, Masayuki Konishi, Huanhuan Hu, Mio Nishimaki, Hyeon-Ki Kim, Hiroki Tabata, Hisao Shimizu, Takashi Arao, Shizuo Sakamoto

    BMC PREGNANCY AND CHILDBIRTH　19　(1)　295-295　2019年8月

    DOI： 10.1186/s12884-019-2452-y 　

    eISSN：1471-2393

  31. 朝もしくは夕の菊芋摂取が血糖値の日内リズムおよび腸内細菌叢に及ぼす影響

    千々木 華子, 金 鉉基, 佐々木 裕之, 深澤 真由子, 大久保 仁, 尾崎 真実帆, 難波 拓哉, 呂 怡錦, 中岡 隆志, 柴田 重信

    日本栄養・食糧学会大会講演要旨集　73回　229-229　2019年4月

    出版者・発行元： (公社)日本栄養・食糧学会

  32. Effects of increased daily physical activity on mental health and depression biomarkers in postmenopausal women. 査読有り

    Masaki Takahashi, Pei Jean Lim, Miku Tsubosaka, Hyeon-Ki Kim, Masashi Miyashita, Katsuhiko Suzuki, Eng Lee Tan, Shigenobu Shibata

    Journal of physical therapy science　31　(4)　408-413　2019年4月

    出版者・発行元： Society of Physical Therapy Science

    DOI： 10.1589/jpts.31.408 　

    ISSN：0915-5287

    eISSN：2187-5626

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    [Purpose] Little is known about the effectiveness of daily physical activity on depression biomarkers in older adults. This study aimed to investigate the effects of increased daily physical activity for 8 weeks on depression biomarkers in postmenopausal women. [Participants and Methods] Thirty-eight postmenopausal females were randomly assigned into a control or an active group and were asked to wear a uniaxial accelerometer for 8 weeks. Blood samples were obtained at baseline and at the end of the intervention. During the intervention, the active group was asked to increase their physical activity level above their usual lifestyle whereas those in the control group maintained their daily lifestyle. [Results] After the 8-week intervention, the step counts of the participants in the active group increased. The serum concentration of the brain-derived neurotrophic factor and serotonin increased significantly in the active group, but not in the control group, as compared with baseline values. The serum concentration of derivatives of reactive oxygen metabolites and biological antioxidant potential did not change after the intervention in either group. [Conclusion] These findings may suggest that promotion of daily physical activity in postmenopausal women has a positive impact on depression without any change in oxidative stress.

  33. Effects of Meal Timing on Postprandial Glucose Metabolism and Blood Metabolites in Healthy Adults 国際誌 査読有り

    Masaki Takahashi, Mamiho Ozaki, Moon-Il Kang, Hiroyuki Sasaki, Mayuko Fukazawa, Tamao Iwakami, Pei Jean Lim, Hyeon-Ki Kim, Shinya Aoyama, Shigenobu Shibata

    NUTRIENTS　10　(11)　2018年11月

    DOI： 10.3390/nu10111763 　

    eISSN：2072-6643

  34. Effects of Chios mastic gum and exercise on physical characteristics, blood lipid markers, insulin resistance, and hepatic function in healthy Japanese men 国際誌 査読有り

    Tomoko Fukazawa, Ilias Smyrnioudis, Masayuki Konishi, Masaki Takahashi, Hyeon Ki Kim, Mio Nishimaki, Mi Xiang, Shizuo Sakamoto

    FOOD SCIENCE AND BIOTECHNOLOGY　27　(3)　773-780　2018年6月

    DOI： 10.1007/s10068-018-0307-3 　

    ISSN：1226-7708

    eISSN：2092-6456

  35. Mild decrease in skin temperature reduces the heart rate during moderate exercise 査読有り

    Konishi M, Tabata H, Ando K, Kim H-K, Nishimaki M, Xiang M, Sakamoto S

    Journal of Sport Science　2017　(5)　305-312　2017年7月

  36. P-56 Maximal fat max oxidation and fatmax are not associated with endurance performance in trained runners 査読有り

    Hiroki Tabata, Hyeon-Ki Kim, Masayuki Konishi, Mio Nishimaki, Mi Xiang, Shizuo Sakamoto

    British Journal of Sports Medicine　50　(Suppl 1)　A62.2-A63　2016年11月

    出版者・発行元： BMJ

    DOI： 10.1136/bjsports-2016-097120.109 　

    ISSN：0306-3674

    eISSN：1473-0480

  37. Reliability and Validity of a Chinese-Translated Version of a Pregnancy Physical Activity Questionnaire 国際誌 査読有り

    Mi Xiang, Massayuki Konishi, Huanhuan Hu, Masaki Takahashi, Wenbi Fan, Mio Nishimaki, Karina Ando, Hyeon-Ki Kim, Hiroki Tabata, Takashi Arao, Shizuo Sakamoto

    MATERNAL AND CHILD HEALTH JOURNAL　20　(9)　1940-1947　2016年9月

    DOI： 10.1007/s10995-016-2008-y 　

    ISSN：1092-7875

    eISSN：1573-6628

  38. Effects of Different Intensities of Endurance Exercise in Morning and Evening on the Lipid Metabolism Response 国際誌 査読有り

    Hyeon-Ki Kim, Karina Ando, Hiroki Tabata, Masayuki Konishi, Masaki Takahashi, Mio Nishimaki, Mi Xiang, Shizuo Sakamoto

    JOURNAL OF SPORTS SCIENCE AND MEDICINE　15　(3)　467-476　2016年9月

    ISSN：1303-2968

  39. 中等度強度の持久性運動が唾液中の生化学成分および歯周病原細菌に与える影響 査読有り

    清水 寿男, 田端 宏樹, 金 鉉基, 西牧 未央, 安藤 加里菜, 項 密, 小西 真幸, 坂本 静男

    スポーツ歯学　20　(1)　1-6　2016年8月

    出版者・発行元： (一社)日本スポーツ歯科医学会

    ISSN：1344-140X

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    中等度強度の持久性運動が唾液中の生化学成分や歯周病原細菌に及ぼす影響について検討したので報告する。27〜52歳で週2回以上の運動習慣をもつ健常男性12名を対象とした。身体測定および運動負荷試験、臨床診査、細菌検査、生化学検査を実施した。検討の結果、中等度強度の持久性運動を行った結果、唾液中の歯周病原細菌と生化学成分が有意に減少していた。このことから、運動が唾液中の歯周病原細菌と生化学成分、それに関連して引き起こされる歯周病態に何らかの変化を及ぼす可能性が示唆された。今後、重度歯周炎患者を対象として、唾液中の遊離ヘモグロビン、血清IgG抗体価や他の歯周病原細菌を調べ、運動と歯周病態との関係性をさらに詳しく検討する必要があると思われる。

  40. Diurnal variation in the diving bradycardia response in young men 国際誌 査読有り

    Masayuki Konishi, Hiroshi Kawano, Mi Xiang, Hyeon-Ki Kim, Karina Ando, Hiroki Tabata, Mio Nishimaki, Shizuo Sakamoto

    CLINICAL AUTONOMIC RESEARCH　26　(2)　135-140　2016年4月

    DOI： 10.1007/s10286-016-0342-1 　

    ISSN：0959-9851

    eISSN：1619-1560

  41. Effects of Acute Endurance Exercise Performed in the Morning and Evening on Inflammatory Cytokine and Metabolic Hormone Responses 国際誌 査読有り

    Hyeon-Ki Kim, Masayuki Konishi, Masaki Takahashi, Hiroki Tabata, Naoya Endo, Shigeharu Numao, Sun-Kyoung Lee, Young-Hak Kim, Katsuhiko Suzuki, Shizuo Sakamoto

    PLOS ONE　10　(9)　e0137567　2015年9月

    DOI： 10.1371/journal.pone.0137567 　

    ISSN：1932-6203

  42. Comparative study between western and asian pharmaceutical plants: The efficacy of the Greek mastic and the Japanese ume 査読有り

    Tomoko Fukazawa, Hias Smyrnioudis, Masayuki Konishi, Masaki Takahashi, Hyeon-Ki Kim, Shigeharu Numao, Shizuo Sakamoto

    Journal of the History of Hellenic Medicine　43　31-38　2014年12月

  43. Acute ingestion of catechin-rich green tea improves postprandial glucose status and increases serum thioredoxin concentrations in postmenopausal women 国際誌 査読有り

    Masaki Takahashi, Masashi Miyashita, Katsuhiko Suzuki, Seong-ryu Bae, Hyeon-Ki Kim, Takuya Wakisaka, Yuji Matsui, Masao Takeshita, Koichi Yasunaga

    BRITISH JOURNAL OF NUTRITION　112　(9)　1542-1550　2014年11月

    DOI： 10.1017/S0007114514002530 　

    ISSN：0007-1145

    eISSN：1475-2662

  44. 運動実施時間帯の違いが一過性持久性運動時における代謝関連指標ならびにホルモン応答に及ぼす影響 査読有り

    金 鉉基, 高橋 将記, 小西 真幸, 田端 宏樹, 遠藤 直哉, 沼尾 成晴, 鈴木 克彦, 坂本 静男

    日本臨床スポーツ医学会誌　22　(3)　497-505　2014年8月

    出版者・発行元： (一社)日本臨床スポーツ医学会

    ISSN：1346-4159

  45. The difference of the influence between acute swimming and running on cardiac fatigue in young male 査読有り

    Endo N, Konishi M, Kim HK, Takahashi M, Nishimaki M, Numao S, Sakamoto S

    Journal of Clinical Physiology　44　(2)　77-89　2014年

  46. Effects of Curcumin Supplementation on Exercise-Induced Oxidative Stress in Humans 査読有り

    M. Takahashi, K. Suzuki, H. Kim, Y. Otsuka, A. Imaizumi, M. Miyashita, S. Sakamoto

    International Journal of Sports Medicine　35　(06)　469-475　2013年10月28日

    出版者・発行元： Georg Thieme Verlag KG

    DOI： 10.1055/s-0033-1357185 　

    ISSN：0172-4622

    eISSN：1439-3964

  47. 韓国仁川市における児童の生活状況とその課題 査読有り

    李 珗京, 金 鉉基, 金 賢植

    食育学研究　7　(2)　82-117　2013年6月

    出版者・発行元： 日本食育学術会議事務局

    ISSN：1881-3291

  48. Effects of sleep deprivation on autonomic and endocrine functions throughout the day and on exercise tolerance in the evening

    Masayuki Konishi, Masaki Takahashi, Hyeon Ki Kim, Naoya Endo, Shigeharu Numao, Shun Takagi, Masashi Miyashita, Taishi Midorikawa, Katsuhiko Suzuki, Shizuo Sakamoto

    Japanese Journal of Physical Fitness and Sports Medicine　2013年

    DOI： 10.7600/jspfsm.62.69 　

    ISSN：0039-906X 1881-4751

  49. Exercise prescription for fat metabolism disorder : From the viewpoint of fat oxidation rate 査読有り

    Sakamoto Shizuo, Konishi Masayuki, Kim Hyeon Ki, ENDOH Naoya, TAKAHASHI Masaki, TAKAGI Syun, MIDORIKAWA Taishi

    The journal of physical fitness and sports medicine : JPFSM　1　(3)　499-504　2012年

    出版者・発行元： The Japanese Society of Physical Fitness and Sports Medicine

    DOI： 10.7600/jpfsm.1.499 　

    ISSN：2186-8131

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    There have been several reports on exercise prescriptions and the effects of exercise on various diseases, particularly for fat metabolism disorder. In recent years, notably from the latter half of the 1990s, studies on effective exercise prescriptions for fat metabolism disorder have taken into account the type of exercise content (type, intensity and duration per session) that has beneficial effects on fat metabolism disorder and the post-exercise recovery period. These studies have analysed the fat oxidation rate as a parameter for examining the beneficial effects of exercise on fat metabolism disorder. In this review, studies, undertaken in Japan and overseas, are introduced that are related to exercise and the fat oxidation rate.

︎全件表示 ︎最初の5件までを表示

MISC 18

  1. 水分摂取の重要性 ー水に関する科学を理解するー

    金 鉉基, 山田 陽介

    日本スポーツ栄養研究誌　18　4-11　2025年2月

  2. 時間運動学の基礎

    金 鉉基

    臨床スポーツ医学　41　(6)　566-570　2024年6月

  3. タンパク質の摂取パターンと骨格筋量

    金 鉉基

    臨床栄養　144　(4)　442-444　2024年5月

  4. タンパク質の摂取タイミングと筋機能

    金 鉉基

    日本時間栄養学会　3　(2)　3-11　2023年10月

  5. 高齢者における身体活動パターンの違いと血中脂質との関連

    金鉉基, 木村有我, 高橋将記, 中岡隆志, 山田陽介, 小野玲, 柴田重信, 柴田重信

    日本時間栄養学会学術大会(Web)　10th　2023年

  6. タンパク質の摂取パターンと身体機能

    金鉉基

    食と医療　(21)　2022年4月

  7. 生活習慣病の予防・改善のための時間運動学と栄養

    金 鉉基

    食と医療　(20)　58-65　2022年2月

  8. 時間栄養学と運動・スポーツパフォーマンス 招待有り

    高橋将記, 金 鉉基

    日本スポーツ栄養研究誌　15　13-19　2022年2月

  9. Chrono-nutrition for health promotion 査読有り

    Hyeon-Ki Kim

    Korean Journal of human movement　3　(1)　2021年4月

  10. 時間栄養学 査読有り

    金 鉉基, 柴田 重信

    体力科学　69　(5)　401-411　2020年10月

    出版者・発行元： (一社)日本体力医学会

    DOI： 10.7600/jspfsm.69.401 　

    ISSN： 0039-906X

    eISSN： 1881-4751

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    <p>In mammals, the circadian rhythms have been shown to regulate several physiological functions, including body temperature, sleep-wake behavior, physical activity, hormonal secretions, and metabolism. These processes are controlled by circadian clock genes, and abnormal circadian rhythms are associated with the development of obesity, diabetes, and lifestyle-related diseases. In addition, the timing of behaviors such as food intake, exercise, and stress influence circadian rhythms, including clock gene expression in peripheral tissues. Therefore, the interaction between nutrition and the circadian clock is so-called "chrono-nutrition" is poised to become an important research field of chronobiology. In this review, we review the effects of a timed-nutrition on circadian clocks and their timing-dependent effects on physiological functions.</p>

  11. 健康のための時間栄養学と時間運動学

    金 鉉基, 柴田 重信

    ソフト・ドリンク技術資料　191　(2)　2020年9月

  12. 運動と食事

    金 鉉基

    食と医療　(12)　60-67　2020年1月

  13. Chrono-exercise for health promotion 査読有り

    Hyeon-Ki Kim

    Korean Journal of human movement　1　(2)　1-12　2019年12月

  14. 【脳機能活性化や健康長寿の鍵となる機能性食品素材・農産物(後編)】時間生物学を利用した機能性食品開発 イヌリンのヒト試験を中心に

    金 鉉基, 柴田 重信

    生物工学会誌　97　(11)　657-660　2019年11月

    出版者・発行元： (公社)日本生物工学会

    ISSN： 0919-3758

  15. 食事・栄養の摂取タイミング : 体内時計作用栄養学の視点から (特集 食と体内時計)

    金 鉉基, 柴田 重信

    食品と科学　61　(1)　57-60　2019年1月

    出版者・発行元： 食品と科学社

    ISSN： 0037-4105

  16. 水泳とランニングにおける一過性長時間運動が脂質代謝に及ぼす影響

    遠藤 直哉, 小西 真幸, 金 鉉基, 西牧 未央, 沼尾 成晴, 坂本 静男

    日本臨床スポーツ医学会誌　23　(4)　S263-S263　2015年10月

    出版者・発行元： (一社)日本臨床スポーツ医学会

    ISSN： 1346-4159

  17. 水泳とランニングの漸増負荷運動中における運動強度による脂質酸化量の比較

    遠藤 直哉, 小西 真幸, 金 鉉基, 高橋 将記, 西牧 未央, 沼尾 成晴, 坂本 静男

    日本臨床スポーツ医学会誌　22　(4)　S151-S151　2014年10月

    出版者・発行元： (一社)日本臨床スポーツ医学会

    ISSN： 1346-4159

  18. 運動実施時間帯の違いが一過性持久性運動時における代謝関連指標ならびにホルモン応答に及ぼす影響

    金 鉉基, 高橋 将記, 沼尾 成晴, 遠藤 直哉, 小西 真幸, 鈴木 克彦, 坂本 静男

    体力科学　61　(6)　634-634　2012年12月

    出版者・発行元： (一社)日本体力医学会

    ISSN： 0039-906X

︎全件表示 ︎最初の5件までを表示

書籍等出版物 3

  1. The Skeletal Muscle: Plasticity, Degeneration and Epigenetics

    Springer International Publishing (Verlag)　2025年8月30日

    ISBN: 9783031883606

  2. 時間栄養学ー時計遺伝子、体内時計、食生活をつなぐ

    化学同人　2020年6月

  3. 菊芋 運動レシピでイキイキ!

    2019年1月

講演・口頭発表等 9

  1. 朝の栄養摂取・身体活動と生理機能 招待有り

    金 鉉基

    第31回日本時間生物学会学術大会　2024年11月16日

  2. タンパク質の摂取タイミングとアスリートの体づくり 招待有り

    金 鉉基, 吉村英一

    第71回日本栄養改善学会学術総会　2024年9月8日

  3. 身体活動と代謝の最新研究からみる代謝性疾患の予防

    髙橋 将記, 金 鉉基

    第76回日本体力医学会　2021年9月17日

  4. 時間栄養学・時間運動学の体力科学への応用とメタボローム活用の可能性

    高橋将記, 金 鉉基, 柴田重信

    第74回日本体力医学会　2019年9月

  5. ヒトの体内時計と身体活動・運動パフォーマンスとの関連

    髙橋将記, 金 鉉基, 安藤加里菜

    第74回日本体力医学会大会　2019年9月

  6. Regulation of blood glucose level by the timing of Inulin intake.

    Hyeon-Ki Kim

    5th Core-to-Core International Symposium "3D Lab-Exchange Program"　2019年2月

  7. 体内時計を考慮した食・栄養学に関するヒト試験 招待有り

    金 鉉基

    「体内時計の調整で広がるヘルスケア領域」セミナー　2018年11月

  8. 時間生物学を利用した機能性食品開発～イヌリンのヒト試験を中心に

    金 鉉基

    BioJapan2018　2018年10月

  9. ヒトにおける朝食内容と健康 招待有り

    金 鉉基

    第5回時間栄養科学研究会　2018年8月

︎全件表示 ︎最初の5件までを表示

共同研究・競争的資金等の研究課題 5

  1. 概日活動リズムの乱れと肥満との関連

    金 鉉基

    2023年11月 ～ 2024年8月

  2. 異なる運動実施時間帯における持久性運動が糖代謝および体内リズム変動に及ぼす影響

    金 鉉基

    2020年4月 ～ 2023年3月

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    持久性運動は血糖値の改善に有効である。一方、耐糖能は日内変動を有することが報告されており、朝に比較して夕方に低下することが示されている。そのため、運動実施時間帯の違いにおける血糖値への影響は異なる可能性がある。そこで、本研究では朝または夕方の短期間持久性運動介入が24時間の血糖値変動に及ぼす影響について検討することを目的とした。 健康な若年男性12名（年齢：21.8 ± 0.2歳、BMI：21.3 ± 0.9 kg/m2）を対象に2つの異なる運動実施時間帯（朝試行[09:00~11:00]および夕方試行[16:00~18:00]）において最大酸素摂取量の60%の強度で60分間のトレッドミル運動を実施した。運動介入は１週間とし、週3回の持久性運動を行なった。各試行は2週間以上の間隔をあけ、無作為化交差比較試験で行った。各試行の24時間の血糖値変動を評価するため、持続血糖測定器（continuous glucose monitoring; CGM）を用いた。 夕方試行で朝試行に比べて運動介入後の24時間の血糖値変動を曲線下面積（area under the curve; AUC）にて検討した結果、朝試行に比較して夕方試行で有意に低い値が示された（P < 0.01）。また、各食後の血糖値変動のAUCにおいても朝試行に比べて夕方試行で低値を示し、朝食と夕食で朝試行に比較して夕方試行で有意な低値が示された（P < 0.05、P < 0.01）。 これらの結果から、夕方の持久性運動は朝の持久性運動に比べて24時間の血糖値改善に有効であることが示唆された。

  3. ライフステージ別の体内時計応用の健康科学研究

    柴田 重信, 金 鉉基, 高橋 将記, 駒田 陽子

    提供機関：Japan Society for the Promotion of Science

    制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)

    研究種目：Grant-in-Aid for Scientific Research (A)

    研究機関：Waseda University

    2019年4月1日 ～ 2022年3月31日

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    年代別つまりライフステージ別の体内時計の特徴をヒトとマウスで明らかにし、学童、成人、中高齢期に分けて時間軸の健康科学に資する時間栄養学、時間運動学、時間休養（睡眠）の重要性を調べた。学童・青年期の学習成績には食や睡眠リズムの規則性が重要であることを、成人の肥満には朝昼夕の食事比を均等化、夕食の炭水化物低下が有効であることを、高齢者の筋萎縮予防には、朝のたんぱく質摂取が大事であることを示した。

  4. 朝または夕の運動でHDL-C引き抜き能および時計遺伝子発現は変動するか

    金 鉉基

    提供機関：Japan Society for the Promotion of Science

    制度名：Grants-in-Aid for Scientific Research

    研究種目：Grant-in-Aid for Early-Career Scientists

    研究機関：Waseda University

    2018年4月1日 ～ 2020年3月31日

    詳細を見る 詳細を閉じる

    運動は心血管疾患や糖尿病のリスクを低減させることが示されている。近年、持続血糖測定器の開発により24時間の血糖値測定が可能となった。先行研究において血中インスリンや血糖値は日内変動を示すことから運動時間帯を考慮する必要がある。しかし、異なる運動実施時間帯における持久性運動が血糖値の日内リズムに及ぼす影響ついては不明な点が多い。そこで、本研究では異なる運動実施時間帯に着目し、持久性運動が血糖値の日内リズムに及ぼす影響について検討した。 健康な若年男性10名を対象とし、ランダムクロスオーバーで行っている。本研究は週3回運動を行う短期間介入を実施している。朝試行（8時～10時）または夕試行（16時～18時）において最大酸素摂取量の60%の強度で60分間の持久性運動をトレッドミルを用いて行った。朝試行と夕試行の間は2週間以上のWash-Out期間を設定している。各試行の介入前後に採血行い、インスリンやカテコラミンなどの血中ホルモンの分析を行っている。さらに、各試行の運動介入前に持続血糖測定器を装着してもらい、運動中および運動後の血糖値変動および日内リズムの分析を行っている。

  5. 運動実施時間帯の違いが代謝応答および血中アディポカインに及ぼす影響

    金 鉉基

    2015年4月24日 ～ 2017年3月31日

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    代謝応答に関連する内分泌系および神経系は日内変動を示す。そのため、異なる運動実施時間帯において代謝応答に違いが見られる可能性がある。しかしながら、朝と夕方の運動実施時間帯の相違が代謝関連指標および血中脂質に与える影響について不明な点が多い。 我々は運動実施時間帯の違い一過性持久性運動時における代謝関連指標および血中脂質に及ぼす影響を検討し、夕方の一過性持久性運動が朝の一過性持久性運動と比較して脂質代謝亢進に影響を与える血中ホルモンの分泌が高まり、夕方の運動後の脂質分解を亢進することを明らかにした。一方、肥満の予防・改善の観点から考えると、異なる運動実施時間帯に行う長期間の持久性運動が代謝関連指標および血中脂質に及ぼす影響について検討する必要がある。異なる運動実施時間帯における長期間の持久性運動が代謝関連指標および血中脂質への影響を解明することは、より的確かつ効果の高い運動処方を考える上で極めて重要であると考えられる。 そこで、我々は中年肥満男性31名（年齢47.5 ± 1.1歳、身長173 ± 0.8 cm、体重83.1 ± 1.6 kg、BMI 27.7 ± 0.4 kg/m2、体脂肪率26.7 ± 0.6 %、mean ± SE）を対象とし、3群【（朝運動群8名：8時～11時）、（夕方運動群12名：17時～20時）、（コントロール群11名：日常生活の維持）】に分けて朝と夕方の異なる運動実施時間帯における長期間の持久性運動が代謝応答に及ぼす影響について検討している。本研究は、介入前測定が終わったところであり、現在進行中である。