研究者詳細

顔写真

ヒラノ　アイ
平野　愛
Ai Hirano
所属
病院　感覚器・理学診療科　耳鼻咽喉科
職名
助教
学位

  • 博士（医学） （東北大学）

e-Rad 研究者番号
60596097

研究分野 1

  • ライフサイエンス / 耳鼻咽喉科学 / 音声障害、嚥下障害

論文 101

  1. Development of intraparotid lymph nodes with special reference to entrapment of the parotid acini in human fetuses.

    Ai Kawamoto-Hirano, Yohei Honkura, Ji Hyun Kim, Gen Murakami, Yukio Katori

    Auris Nasus Larynx　2026年12月

    DOI： 10.1016/j.anl.2026.09.008 　

  2. Distinct delayed development of the basisphenoid–ethmoid interface in human fetuses: a histological study using human fetuses

    Ai Hirano-Kawamoto, Masahito Yamamoto, Yohei Honkura, Gen Murakami, Shogo Hayashi, Yukio Katori

    Anatomy & Cell Biology　2026年6月30日

    DOI： 10.5115/acb.25.299 　

  3. Supportive fibrous tissues of the nasal epithelium with special reference to the site-dependent difference

    Motonobu Abe, Kei Kitamura, Kazuma Morita, Kenta Abe, Ai Hirano-Kawamoto, Gen Murakami, Shin-ichi Abe

    Anatomy & Cell Biology　2026年3月31日

    DOI： 10.5115/acb.25.252 　

  4. Association Between Oral and Pharyngeal Functions in Patients in Medical-Dental Cooperation at an Acute Hospital. 国際誌

    Ryo Tagaino, Kana Saijo, Naru Shiraishi, Takamasa Komiyama, Kuniyuki Izumita, Takuma Hisaoka, Ai Hirano, Jun Ota, Yukio Katori, Toru Ogawa, Keiichi Sasaki, Nobuhiro Yoda, Hiroshi Egusa, Shigeto Koyama

    Journal of oral rehabilitation　2026年3月8日

    DOI： 10.1111/joor.70176 　

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    BACKGROUND: Recent studies have focused on oral frailty and hypofunction, and their relationship with swallowing function and dysphagia. These play especially important roles in patients with dysphagia in medical-dental cooperation at acute hospitals. OBJECTIVE: This study aimed to assess oral frailty, in terms of nutritional intake by evaluating oral and swallowing functions simultaneously, in patients consulting at an acute hospital. METHODS: This cross-sectional study was conducted at the Center for Dysphagia of Tohoku University Hospital and involved a comprehensive survey of 183 patients. Their oral function and oral status were evaluated, which included factors such as poor oral hygiene, oral dryness, tongue-lip motor function, tongue pressure, and masticatory performance. Additionally, swallowing status was evaluated using various methods, including a questionnaire related to swallowing, Hyodo-Komagane score, modified water-swallowing, and repetitive saliva swallowing tests. This thorough approach ensured the validity and reliability of our findings. RESULTS: Approximately 60% of patients had head and neck tumours, degenerative diseases, and muscular diseases. Therefore, a high prevalence of oral hypofunction was observed. Furthermore, since 41.5% of patients had limited tongue movement, a characteristic correlation existed between the oral diadochokinesis and Hyodo-Komagane score. CONCLUSION: These results suggest that oral dryness score, oral diadochokinesis, and tongue pressure are associated with oral hypofunction and dysphagia. Additionally, patients with hypofunction and decreased tongue pressure may have hypopharyngeal residuals. The medical-dental cooperation in an acute hospital allows for the simultaneous assessment of oral and swallowing functions. This suggests a potential to contribute to the practice of safe oral intake and appropriate rehabilitation.

  5. Development of the occipitopetrosal junctions: A histological study using human fetuses

    Ai Hirano‐Kawamoto, Yohei Honkura, Chun‐Ai Li, Samuel Verdugo‐López, Gen Murakami, Jose Francisco Rodríguez‐Vázquez, Yukio Katori

    The Anatomical Record　2026年2月

    DOI： 10.1002/ar.25687 　

  6. A novel division of the nasalis muscle of face with special reference to the elastic fiber-mediated insertion: a cadaveric study. 国際誌

    Kei Kitamura, Ji Hyun Kim, Ai Hirano-Kawamoto, Yukio Katori, Gen Murakami, Shin-Ichi Abe, Hitoshi Yamamoto

    Surgical and radiologic anatomy : SRA　48　(1)　39-39　2026年1月13日

    DOI： 10.1007/s00276-025-03807-5 　

  7. Nationwide Survey on Recurrent Respiratory Papillomatosis in Japan: Analysis of Long-Term Patients. 国際誌

    Shigeyuki Murono, Tomotaka Kawase, Yusuke Watanabe, Rumi Ueha, Hiroumi Matsuzaki, Yuri Hirai, Kiyohito Hosokawa, Yoshikazu Kikuchi, Taizo Yokokawa, Ai Hirano, Hiroki Takeda, Yasushi Toh, Nobuhiko Oridate, Akihiro Shiotani, Yukio Katori

    The Laryngoscope　2025年12月16日

    DOI： 10.1002/lary.70314 　

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    OBJECTIVES: To investigate the long-term disease status, clinical course, laryngeal distribution, management, and postoperative recurrence of recurrent respiratory papillomatosis (RRP) diagnosed before the first nationwide survey in Japan. METHODS: As described in our previous report, we conducted a questionnaire-based survey targeting 782 institutions, asking about the presence of RRP patients during the survey period in 2018 and 2019. A detailed questionnaire was subsequently sent to the 196 institutions that reported having at least one patient, inquiring about age, sex, history of recent surgery, Derkay's score, surgical procedures, and postoperative recurrence. The present study analyzed data from patients who had been diagnosed prior to the beginning of the survey period. RESULTS: Data on 318 previously diagnosed patients were collected from 90 institutions. At their first follow-up visit during the survey period, 85 patients (26.7%) had a Derkay's anatomical score of 0. The true vocal folds were the most commonly affected laryngeal subsites. Of the 318 patients, 165 underwent surgery after the first follow-up visit, and recurrence occurred in 106 after this surgery. The 6- and 12-month additional surgery-free rates were 58.9% and 31.8%. These rates were significantly higher in patients who had undergone one or no surgery within a year prior to the first follow-up visit during the survey period than in those who had undergone two or more surgeries (p = 0.01). CONCLUSION: The present study revealed real-world data suggesting that the number of recent surgeries and Derkay's anatomical score may be associated with the clinical course of previously diagnosed RRP.

  8. A case of Inclusion Body Myositis with Isolated Dysphagia: An Earlier-stage Diagnosis Using a Surgical Specimen from Cricopharyngeal Myotomy.

    Kimihiko Kaneko, Rumiko Izumi, Naoki Suzuki, Jun Ohta, Ai Hirano-Kawamoto, Yukio Katori, Masashi Aoki

    Internal medicine (Tokyo, Japan)　2025年10月16日

    DOI： 10.2169/internalmedicine.6284-25 　

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    A 76-year-old man was admitted to our hospital with progressive dysphagia. His physical and neurological examination results were normal, except for dysphagia. Videofluoroscopy of swallowing demonstrated a cricopharyngeal bar, a highly specific finding for inclusion body myositis (IBM). A cricopharyngeal muscle specimen was obtained during cricopharyngeal myotomy to improve his symptoms. Muscle histopathology successfully led to the diagnosis of IBM. Dysphagia can occasionally precede limb weakness in IBM, and an early histopathological diagnosis using limb muscles is challenging. In such cases, a histopathological evaluation via myotomy may be useful for making an early diagnosis and facilitating appropriate treatment.

  9. Branched ends of Reichert’s cartilage in the ear: a histological study using human near-term fetuses

    Chun-Ai Li, Zhe-Wu Jin, Yohei Honkura, Ai Hirano-Kawamoto, Gen Murakami, Jose Francisco Rodríguez-Vázquez, Yukio Katori

    Anatomy & Cell Biology　2025年6月30日

    DOI： 10.5115/acb.24.220 　

  10. Origin, communication and course of the vagus nerve auricular branch with special references to the mastoid canaliculus for the nerve: A study using human fetus histological sections

    José Francisco Rodríguez-Vázquez, Samuel Verdugo-López, Ji Hyun Kim, Ai Hirano-Kawamoto, Gen Murakami, Masahito Yamamoto

    Annals of Anatomy - Anatomischer Anzeiger　259　152389-152389　2025年4月

    出版者・発行元： Elsevier BV

    DOI： 10.1016/j.aanat.2025.152389 　

    ISSN：0940-9602

  11. Risk factors of pneumonia after thoracic aortic surgery

    Akari Sawada, Jun Suzuki, Yusuke Suzuki, Ryoukichi Ikeda, Jun Ohta, Ai Hirano-Kawamoto, Yoshikatsu Saiki, Yukio Katori

    Auris Nasus Larynx　2025年4月

    DOI： 10.1016/j.anl.2025.02.002 　

  12. Association between the Hospital Anxiety and Depression Scale and Swallowing Function in Dysphagic Patients in Japan. 国際誌

    Takuma Hisaoka, Jun Suzuki, Ryoukichi Ikeda, Ai Hirano-Kawamoto, Jun Ohta, Yukio Katori

    Auris, nasus, larynx　52　(3)　222-228　2025年3月21日

    DOI： 10.1016/j.anl.2025.03.001 　

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    OBJECTIVE: Dysphagia affects 2.3 %-16 % of the general population and increases with age. It can lead to malnutrition, weight loss, aspiration pneumonia, and emotional symptoms such as anxiety and depression. Mental health disorders impact appetite and muscle mass, further worsening dysphagia. Additionally, cultural and economic factors influence anxiety and depression, which can either result from or contribute to dysphagia. Studies on the relationship between anxiety, depression, and swallowing function using FEES are limited in Asian populations. The Hospital Anxiety and Depression Scale (HADS) is a useful tool for assessing mood disorders. Therefore, in this study, we aimed to investigate the associations among anxiety, depression, and swallowing function in Japanese patients with dysphagia using HADS. METHODS: Data on age; sex; HADS; Eating Assessment Tool-10 (EAT-10); Functional Oral Intake Scale (FOIS); tongue pressure; Hyodo score, a scoring system for evaluating the swallowing function determined by flexible endoscopic evaluation of swallowing (FEES); and videofluoroscopic dysphagia scale (VDS), assessed by videofluoroscopic swallowing study, were collected and analyzed from medical records. Hyodo score consists of four parameters: (1) salivary pooling in the vallecula and piriform sinuses; (2) glottal closure reflex or cough reflex induced by touching the epiglottis or arytenoid; (3) swallowing reflex induced by colored water; and (4) extent of pharyngeal clearance after colored water is swallowed. The Mann-Whitney U test, Fisher's exact test, and multiple logistic regression analyses were used to estimate associations between HADS and swallowing function. RESULTS: No significant relationships were observed between the EAT-10, FOIS, and VDS with HADS scores. Patients with depression were associated with a significantly higher percentage of anorexia complaints (p = 0.047). Lower tongue pressure was observed in patients with depression than in patients without depression (p = 0.002). Patients with anxiety had better swallowing function, as assessed by the Hyodo score (p = 0.047). Fluid clearance, a component of the Hyodo score, was significantly better in patients with anxiety (p = 0.03) even after propensity score matching adjusted for the effects of age, sex, and fluid clearance. CONCLUSION: In patients with anxiety, swallowing function assessed by FEES was favorable, whereas a higher proportion of patients with depression reported decreased appetite, and lower tongue pressure. This discrepancy between subjective dysphagia and FEES findings suggests that patients with anxiety may underestimate their swallowing function.

  13. Time-course changes in videofluoroscopic findings during developmental and aging stages in mice. 国際誌

    Hiyori Takahashi, Jun Suzuki, Ryoukichi Ikeda, Takuma Hisaoka, Yasutoshi Koshiba, Jun Ohta, Ai Hirano-Kawamoto, Yukio Katori

    Neuroreport　2025年1月22日

    DOI： 10.1097/WNR.0000000000002140 　

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    Videofluoroscopic swallow study methodology in mice has recently been established; however, details of developmental and age-related changes remain unclear. This study aimed to reveal the changes in swallowing associated with the entire lifespan of mice using the videofluoroscopic swallow study methodology. We tested six age groups of male C57BL/6J mice (4, 8, 16, 54, 77, and 104 weeks old; n = 5 for each group, respectively). The videofluoroscopic swallow study analyzed the bolus area, pharyngeal transit time, interswallow interval, lick-swallow ratio, and lick rate. Significant age differences were found in the bolus area and lick rate. The bolus area increased significantly as the mice grew older. There was a significant increase in the lick rate from 4 to 8 weeks (P < 0.001) and then a significant decrease from 8 to 104 weeks (P < 0.01). No significant difference was observed between the various stages in the lick-swallow ratio, interswallow interval, or pharyngeal transit time. There was a significant positive correlation between the body weight and bolus area. This study revealed the detailed changes in swallowing at each life stage from swallowing maturation to old age in the mice. Our research may serve as a guide for future studies on swallowing in humans.

  14. Development and growth of fasciae in and around the esophageal hiatus: a histological study using human fetuses

    Ai Hirano-Kawamoto, Yohei Honkura, Gen Murakami, Shin-ichi Abe, Jose Francisco Rodríguez-Vázquez, Yukio Katori

    Surgical and Radiologic Anatomy　2024年12月2日

    DOI： 10.1007/s00276-024-03517-4 　

  15. [ANL Secondary Publication] デュシェンヌ型筋ジストロフィー患者の肺炎発症予測に有効なベットサイドでの嚥下機能評価

    平野 愛, 池田 怜吉, 高橋 俊明, 谷口 さやか, 吉岡 勝, 田中 洋康, 大泉 英樹, 戸恒 智子, 大城 咲, 馬場 徹, 武田 篤, 小林 祐太, 太田 淳, 香取 幸夫

    日本耳鼻咽喉科頭頸部外科学会会報　127　(8)　960-961　2024年8月

    出版者・発行元： (一社)日本耳鼻咽喉科頭頸部外科学会

    ISSN：2436-5793

    eISSN：2436-5866

  16. Guidance of clinical management for patients with tonsillar focal disease

    Miki Takahara, Akira Doi, Ayako Inoshita, Junichiro Ohori, Masamitsu Kono, Ai Hirano, Takuya Kakuki, Kentaro Yamada, Hirofumi Akagi, Kenichi Takano, Seiichi Nakata, Yasuaki Harabuchi

    Auris Nasus Larynx　2024年8月

    DOI： 10.1016/j.anl.2024.05.010 　

  17. 抗inflammaging-抗加齢・炎症対策による健康寿命維持 小動物用嚥下透視装置を用いた嚥下研究 加齢・病態モデルを用いて

    鈴木 淳, 久岡 巧麻, 高橋 ひより, 小柴 康利, 太田 淳, 平野 愛, 池田 怜吉, 香取 幸夫

    日本耳鼻咽喉科免疫アレルギー感染症学会抄録集　4回　101-101　2024年3月

    出版者・発行元： 日本耳鼻咽喉科免疫アレルギー感染症学会

    eISSN：2435-7987

  18. 抗inflammaging-抗加齢・炎症対策による健康寿命維持 小動物用嚥下透視装置を用いた嚥下研究 加齢・病態モデルを用いて

    鈴木 淳, 久岡 巧麻, 高橋 ひより, 小柴 康利, 太田 淳, 平野 愛, 池田 怜吉, 香取 幸夫

    日本耳鼻咽喉科免疫アレルギー感染症学会抄録集　4回　101-101　2024年3月

    出版者・発行元： 日本耳鼻咽喉科免疫アレルギー感染症学会

    eISSN：2435-7987

  19. Characteristic findings in the human fetus vestibule: A human temporal bone study

    Yohei Honkura, Yukio Katori, Ai Hirano-Kawamoto, Tetsuaki Kawase, Jose Francisco Rodríguez-Vázquez, Gen Murakami, Hiroshi Abe

    Auris Nasus Larynx　2024年2月

    DOI： 10.1016/j.anl.2023.05.004 　

  20. 多職種・多部門が連携した誤嚥・窒息事故防止のための取り組み

    田畑 雅央, 平野 愛, 太田 淳, 白石 成, 土肥 千秋, 香取 幸夫

    医療の質・安全学会誌　18　(Suppl.)　364-364　2023年11月

    出版者・発行元： (一社)医療の質・安全学会

    ISSN：1881-3658

    eISSN：1882-3254

  21. 反回神経麻痺ゼロを目指したベストアプローチ 声は良くなります 片側性反回神経麻痺患者の音声改善手術

    香取 幸夫, 平野 愛, 佐藤 剛史

    日本胸部外科学会定期学術集会　76回　CDPD1-1　2023年10月

    出版者・発行元： (一社)日本胸部外科学会

  22. Nasal capsule ossification: A histological study using human foetuses to find an association between the foetus and adult morphologies of the nasal wall. 国際誌 国際共著 査読有り

    Masahito Yamamoto, Shogo Hayashi, Yohei Honkura, Ai Hirano-Kawamoto, Yukio Katori, Gen Murakami, José Francisco Rodríguez-Vázquez, Shinichi Abe

    Journal of anatomy　243　(3)　517-533　2023年9月

    DOI： 10.1111/joa.13867 　

    ISSN：0021-8782

    eISSN：1469-7580

  23. 嚥下医学ベーシックサイエンス 食道運動を支配する腸管神経叢について

    平野 愛, 香取 幸夫

    嚥下医学　12　(2)　172-176　2023年9月

    出版者・発行元： 日本嚥下医学会

    ISSN：2186-3199

  24. Long-term voice evaluation after arytenoid adduction surgery in patients with unilateral vocal fold paralysis. 国際誌

    Kenichi Watanabe, Ai Hirano, Yuta Kobayashi, Takeshi Sato, Yohei Honkura, Yukio Katori

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery　2023年8月16日

    DOI： 10.1007/s00405-023-08165-9 　

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    PURPOSE: Laryngeal framework surgery, including medialization laryngoplasty and arytenoid adduction (AA), is expected to have a lasting or permanent effect in patients with unilateral vocal fold paralysis (UVFP); however, there are few reports about the long-term outcomes of AA. This study aimed to evaluate the long-term postoperative effects of AA surgery and examine its stability and reliability. METHODS: This study collected the voice handicap index (VHI) questionnaire from patients with UVFP who underwent AA more than 2 years previously. The VHI values preoperatively and 3 months postoperatively (early postoperative evaluation) were retrospectively calculated, and VHI values more than 2 years after surgery (late postoperative evaluation) were collected by mailing a sheet to the patients and asking to fill and return it. Possible influenced subscales such as age, sex, causes of UVFP, affected side, and surgeons were also analyzed. RESULTS: A total of 77 patients with UVFP who underwent AA had significantly lower early and late postoperative evaluations than preoperative evaluations. In 38 patients with no missing values, there were no significant differences between early and late postoperative evaluations, measured at a median of approximately 5 years. There were also no significant differences between early and late postoperative evaluations in any of the subscale groups. CONCLUSION: Patients with UVFP who underwent AA surgery achieved stable voice improvement in the long term after surgery.

  25. The Transition of Pediatric Tracheobronchial Foreign Body Cases in the Past 36 Years: A Retrospective Single-Center Study in Japan. 査読有り

    Hiyori Takahashi, Jun Suzuki, Ryoukichi Ikeda, Tetsuya Oishi, Jun Ohta, Ai Hirano-Kawamoto, Yukio Katori

    The Tohoku journal of experimental medicine　2023年8月3日

    DOI： 10.1620/tjem.2023.J062 　

  26. Transient connection between the vestibular aqueduct and utricle: a study using sagittal sections of human embryonic heads. 国際誌

    Yohei Honkura, Yukio Katori, Ai Hirano-Kawamoto, Tetsuaki Kawase, Jose Francisco Rodríguez-Vázquez, Gen Murakami, Hiroshi Abe

    Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft　250　152113-152113　2023年6月8日

    DOI： 10.1016/j.aanat.2023.152113 　

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    BACKGROUND: The aqeductus vestibuli (aqueduct) is believed to connect to the saccule in embryos and adults. However, in embryos, the saccule and utricle are known to communicate widely to provide a common endolymph space "atrium". METHODS: Using sagittal histological sections from five embryos (crown-rump length or CRL, 14-21mm), nine early fetuses (CRL 24-35mm) and 12 midterm and near-term fetuses (CRL 82-272mm), we revisited the development and growth of the human ear aqueduct. RESULTS: The atrium took on a thick tube-like appearance as an antero-inferior continuation of the aqueduct, but soon divided into multiple gulfs. Most of the gulfs corresponded to the ampullae of semicircular ducts, while one gulf at the antero-medio-inferior corner corresponded to the future saccule. Notably, in eight of the 14 embryos and early fetuses, the aqueduct ended at the utricle near the primitive ampulla of the anterior (superior) or posterior semicircular duct. Conversely, an embryo of CRL 21mm was the smallest specimen in which the aqueduct joined the gulf-like saccule. At midterm and near-term, the growing perilymph space separated the aqueduct from the utricle and appeared to push the aqueduct toward the saccule. A topographical change occurred between the embryonic superiorly located utricle and the inferiorly-located saccule to create the antero-posterior arrangement in adults. CONCLUSIONS: Consequently, the vestibular end of the aqueduct was most likely to migrate anteriorly from the utricle to the saccule at 6-8 weeks possibly due to differential growth of the endothelium. Previous reconstructions of the embryonic aqueduct might be biased by the adult morphology.

  27. [Secondary Publication] 本邦の嚥下障害患者における,咽喉頭感覚評価法に関するアンケート調査

    神林 友紀, 加藤 健吾, 池田 怜吉, 鈴木 淳, 本藏 陽平, 平野 愛, 太田 淳, 加賀谷 斉, 井上 誠, 兵頭 政光, 大森 孝一, 末廣 篤, 岡崎 達馬, 出江 紳一, 小山 重人, 佐々木 啓一, 熊井 良彦, 二藤 隆春, 栗山 進一, 小川 武則, 香取 幸夫

    日本耳鼻咽喉科頭頸部外科学会会報　126　(3)　243-244　2023年3月

    出版者・発行元： (一社)日本耳鼻咽喉科頭頸部外科学会

    ISSN：2436-5793

    eISSN：2436-5866

  28. [Secondary Publication] 本邦の嚥下障害患者における,咽喉頭感覚評価法に関するアンケート調査

    神林 友紀, 加藤 健吾, 池田 怜吉, 鈴木 淳, 本藏 陽平, 平野 愛, 太田 淳, 加賀谷 斉, 井上 誠, 兵頭 政光, 大森 孝一, 末廣 篤, 岡崎 達馬, 出江 紳一, 小山 重人, 佐々木 啓一, 熊井 良彦, 二藤 隆春, 栗山 進一, 小川 武則, 香取 幸夫

    日本耳鼻咽喉科頭頸部外科学会会報　126　(3)　243-244　2023年3月

    出版者・発行元： (一社)日本耳鼻咽喉科頭頸部外科学会

    ISSN：2436-5793

    eISSN：2436-5866

  29. Videofluoroscopic Dysphagia Scale as an Additional Indicator of Gastrostomy in Patients with Amyotrophic Lateral Sclerosis with Dysphagia. 査読有り

    Tomomi Shijo, Ryoukichi Ikeda, Naoki Suzuki, Jun Ohta, Jun Suzuki, Ai Hirano-Kawamoto, Kengo Kato, Kensuke Ikeda, Rumiko Izumi, Shio Mitsuzawa, Hitoshi Warita, Masaaki Kato, Masashi Aoki, Yukio Katori

    The Tohoku journal of experimental medicine　259　(4)　293-300　2023年1月26日

    DOI： 10.1620/tjem.2023.J005 　

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    Pseudobulbar palsy and bulbar palsy cause dysphagia in patients with amyotrophic lateral sclerosis (ALS). Dysphagia in patients with ALS not only increases the risk of aspiration and pneumonia but also leads to malnutrition and weight loss, which are poor prognostic factors. Gastrostomy is the preferred route of feeding and nutritional support in patients with dysphagia. However, there are no established standards to determine the ideal timing of gastrostomy for patients with ALS. Therefore, we used the videofluoroscopic dysphagia scale (VDS), which objectively quantifies swallowing function, in videofluoroscopic swallowing study (VFSS) to investigate whether this scale at diagnosis can be a useful predictor for the timing of gastrostomy. We retrospectively evaluated 22 patients with ALS who were diagnosed at our hospital. We assessed the VDS scores in all patients within 3 months of diagnosis. A decline in the ALS functional rating scale revised (ALSFRS-R) scores was used as an indicator of disease progression. As a result, we found that the VDS score of the pharyngeal phase and the total VDS score were significantly correlated with the ΔALSFRS-R scores. These scores were also associated with the existing indicators for the timing of gastrostomy, i.e., decreased body weight and percent-predicted forced vital capacity. We demonstrated the noninferiority of the VDS scores relative to the existing indicators. In addition, the VDS score of the pharyngeal phase was significantly correlated with the time from diagnosis to gastrostomy. The VDS score could estimate the timing of gastrostomy in patients with ALS with dysphagia at diagnosis.

  30. Postoperative Swallowing Function in Patients with Deep Neck Infection. 国際誌 査読有り

    Shohei Ashizawa, Takuma Hisaoka, Ryoukichi Ikeda, Rina Kamihata, Jun Suzuki, Ai Hirano-Kawamoto, Jun Ohta, Yukio Katori

    Biomedicine hub　8　(1)　72-78　2023年

    出版者・発行元： S. Karger AG

    DOI： 10.1159/000533526 　

    eISSN：2296-6870

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    INTRODUCTION: Early detection of dysphagia risk, initiating rehabilitation, and resumption of appropriate diet based on swallowing function is important during deep neck infection (DNI) control. This study aimed to evaluate the extent of cervical abscess development, particularly in the deep neck space, and its relationship to postoperative swallowing function. METHODS: A retrospective chart review was performed for all DNI cases treated between April 2015 and April 2021. Deep neck spaces were divided into categories based on computed tomography findings. Functional Oral Intake Scale (FOIS) scores of 4 or higher was defined as normal or slight swallowing disorder and 3 or lower as dysphagia. RESULTS: Seventeen cases were included in the analysis. Based on FOIS, 14 cases were classified into the dysphagia group at 2 weeks after surgery, 11 cases at 4 weeks, and 8 cases at 8 weeks. There was no significant difference between the location of the abscess and dysphagia at 2 weeks after surgery. Patients with anterior cervical space abscess significantly increased dysphagia 4 weeks (p = 0.018) and 8 weeks (p = 0.036) after surgery. CONCLUSION: Abscess formation in the anterior cervical space may be associated with prolonged dysphagia after treatment due to inflammation and scarring of the muscles associated with swallowing.

  31. 特集 重症化に注意! 口腔･咽頭･喉頭の急性感染症 深頸部感染症 深頸部感染症の合併症とその対応 嚥下障害

    平野 愛, 太田 淳

    JOHNS　38　(11)　1499-1502　2022年11月1日

    出版者・発行元： 東京医学社

    DOI： 10.24479/ohns.0000000381 　

    ISSN：0910-6820

  32. Bedside evaluation of swallowing function to predict aspiration pneumonia in Duchenne muscular dystrophy. 国際誌

    Ai Kawamoto-Hirano, Ryoukichi Ikeda, Toshiaki Takahashi, Sayaka Taniguchi, Masaru Yoshioka, Hiroyasu Tanaka, Hideki Oizumi, Tomoko Totsune, Saki Oshiro, Toru Baba, Atsushi Takeda, Yuta Kobayashi, Jun Ohta, Yukio Katori

    Auris, nasus, larynx　50　(2)　247-253　2022年8月13日

    DOI： 10.1016/j.anl.2022.07.006 　

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    OBJECTIVE: Aspiration pneumonia is one of the leading causes of death in patients with muscular dystrophy; therefore, it is important to predict its occurrence in the clincal setting. We aimed to examine the usefulness of repeated saliva swallowing test (RSST), modified water swallowing test (MWST), and flexible endoscopic evaluation of swallowing (FEES) for evaluating the Hyodo score at the bedside, to predict the risk of aspiration pneumonia in patients with Duchenne muscular dystrophy (DMD). METHODS: In this retrospective cohort study involving 43 patients, we evaluated the swallowing function using the RSST, MWST, and FEES, and predicted the likelihood of aspiration pneumonia within 2 years after the assessment. The Hyodo score, a scoring system for evaluating the swallowing function determined by the FEES, was used. RESULTS: Pneumonia was observed in 14 patients (32.6%). The RSST was not significantly useful for predicting the onset of pneumonia. The MWST was reported to have a cutoff value of < 4 points. Significantly more patients in the pneumonia group had an MWST score of < 4 points. The results revealed that the occurrence of pneumonia could be predicted based on a Hyodo cutoff score of ≥ 6. Significantly more patients in the pneumonia group had an MWST score of < 4 or a Hyodo score of ≥ 6. CONCLUSIONS: Combining MWST and FEES is useful for evaluating the bedside swallowing function and predicting the onset of pneumonia.

  33. The characteristics of dysphagia and the incidence of pneumonia in Myotonic dystrophy type 1 patients especially concerning swallowing function evaluated by endoscopy. 国際誌 査読有り

    Tomonori Kambayashi, Ai Hirano-Kawamoto, Toshiaki Takahashi, Sayaka Taniguchi, Masaru Yoshioka, Hiroyasu Tanaka, Hideki Oizumi, Tomoko Totsune, Saki Oshiro, Toru Baba, Atsushi Takeda, Takuma Hisaoka, Jun Ohta, Ryoukichi Ikeda, Jun Suzuki, Kengo Kato, Yukio Katori

    Auris, nasus, larynx　49　(6)　1003-1008　2022年4月12日

    DOI： 10.1016/j.anl.2022.04.003 　

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    OBJECTIVE: The objectives of the study were to clarify the characteristics of dysphagia and the incidence of pneumonia in Myotonic dystrophy type 1 (DM1) patients, and to investigate the relationship between the development of pneumonia and the DM1 patient's background, especially concerning swallowing function evaluated by endoscopy. METHODS: The subjects were 88 DM1 patients who underwent swallowing function evaluation. The severity of disease in DM1patients was assessed based on the muscular impairment rating scale (MIRS), and the number of CTG repeats. Patients were divided into two groups; those who developed aspiration pneumonia within two years after swallowing assessment and those who did not develop aspiration pneumonia. Swallowing function was assessed using the food intake level scale (FILS), repetitive saliva swallowing test (RSST), the modified water swallowing test (MWST), and the Hyodo score. RESULTS: Onset of pneumonia within two years of assessment was observed in 22 cases (25%). Age, FILS, and Hyodo score were significantly different between pneumonia and non-pneumonia groups. There was a significant difference in swallowing function tests such as FILS, RSST, and Hyodo score between males and females. The Hyodo score cutoff value for predicting pneumonia within two years was determined by ROC analysis. A cutoff value of 6 was found to have a sensitivity of 0.545 and a specificity of 0.833 (area under the curve=0.722). CONCLUSION: It is important to evaluate the swallowing function of DM1 patients by endoscopy to prevent aspiration pneumonia. In addition, male patients are more likely to deteriorate in swallowing function and should be carefully monitored.

  34. Patulous Eustachian Tube Patients With Oculopharyngeal Muscular Dystrophy. 国際誌

    Kento Ishigakii, Ryoukichi Ikeda, Jun Suzuki, Ai Hirano-Kawamoto, Jun Ohta, Kengo Kato, Rumiko Izumi, Naoki Suzuki, Masashi Aoki, Tetsuaki Kawase, Yukio Katori

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology　43　(4)　e442-e445　2022年4月1日

    DOI： 10.1097/MAO.0000000000003494 　

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    OBJECTIVES: To describe cases of patulous Eustachian tube (PET) or patent ET conditions in oculopharyngeal muscular dystrophy (OPMD). PATIENTS: Four cases of PET or patent ET conditions with OPMD. MAIN OUTCOME MEASURES: Clinical case records, objective ET function tests (tubo-tympano-aerodynamic graphy and sonotubometry), and swallowing function (videoendoscopic examination and Food Intake Level Scale) were analyzed. RESULTS: Two cases of definite PET, one case of possible PET, and one case lacking aural symptoms with findings of patent ET. All patients have ptosis, and three cases have dysphagia. Body mass index indicated that three cases were underweight. Magnetic resonance imaging in case 4 showed atrophy and fat replacement of palatine and masticatory muscles. CONCLUSIONS: It is important to consider PET or patent ET conditions when OPMD patients describe aural symptoms.

  35. 喉頭枠組み手術を行う片側性声帯麻痺患者の発話検査

    香取 幸夫, 佐藤 剛史, 平野 愛, 本藏 陽平, 渡邊 健一

    日本気管食道科学会会報　73　(2)　s10-s10　2022年4月

    出版者・発行元： (NPO)日本気管食道科学会

    ISSN：0029-0645

    eISSN：1880-6848

  36. 当科で経験した小児気管・気管支異物の過去36年の推移について

    高橋 ひより, 鈴木 淳, 池田 怜吉, 太田 淳, 平野 愛, 大石 哲也, 香取 幸夫

    日本耳鼻咽喉科頭頸部外科学会会報　125　(4)　771-771　2022年4月

    出版者・発行元： (一社)日本耳鼻咽喉科頭頸部外科学会

    ISSN：2436-5793

    eISSN：2436-5866

  37. 嚥下障害に対するチーム医療 急性期病院(医育機関)における活動

    香取 幸夫, 太田 淳, 平野 愛

    日本気管食道科学会会報　73　(2)　129-129　2022年4月

    出版者・発行元： (NPO)日本気管食道科学会

    ISSN：0029-0645

    eISSN：1880-6848

  38. 喉頭枠組み手術を行う片側性声帯麻痺患者の発話検査

    香取 幸夫, 佐藤 剛史, 平野 愛, 本藏 陽平, 渡邊 健一

    日本気管食道科学会会報　73　(2)　s10-s10　2022年4月

    出版者・発行元： (NPO)日本気管食道科学会

    ISSN：0029-0645

    eISSN：1880-6848

  39. 筋ジストロフィー患者の病型による嚥下内視鏡検査、舌圧測定結果と肺炎発症率の違いについて

    平野 愛, 神林 友紀, 池田 怜吉, 太田 淳, 香取 幸夫

    日本気管食道科学会会報　73　(2)　s21-s21　2022年4月

    出版者・発行元： (NPO)日本気管食道科学会

    ISSN：0029-0645

    eISSN：1880-6848

  40. Long-term outcomes after surgery to prevent aspiration for patients with amyotrophic lateral sclerosis. 国際誌

    Temma Soga, Naoki Suzuki, Kengo Kato, Ai Kawamoto-Hirano, Yuko Kawauchi, Rumiko Izumi, Masaya Toyoshima, Shio Mitsuzawa, Tomomi Shijo, Kensuke Ikeda, Hitoshi Warita, Yukio Katori, Masashi Aoki, Masaaki Kato

    BMC neurology　22　(1)　94-94　2022年3月16日

    DOI： 10.1186/s12883-022-02619-z 　

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    BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons selectively. In particular, weakness in respiratory and swallowing muscles occasionally causes aspiration pneumonia and choking, which can be lethal. Surgery to prevent aspiration, which separates the trachea and esophagus, can reduce the associated risks. Central-part laryngectomy (CPL) is a relatively minimally invasive surgery to prevent aspiration. No studies have been conducted on the long-term outcomes of surgery to prevent aspiration in patients with ALS. This case series aimed to determine the long-term outcomes of surgery to prevent aspiration and the use of a continuous low-pressure aspirator in patients with ALS by evaluating the frequency of intratracheal sputum suctions performed per day, intra- and postoperative complications, oral intake data, and satisfaction of patients and their primary caregiver to predict improvement in patients' quality of life (QOL). METHODS: We report a case series of six patients with ALS who underwent CPL along with tracheostomy to prevent aspiration between January 2015 and November 2018. We evaluated their pre- and postoperative status and administered questionnaires at the time of last admission to the patients and their primary caregivers. RESULTS: The mean follow-up period after CPL was 33.5 months. Aerophagia was a common postoperative complication. The use of a continuous low-pressure aspirator resulted in reduced frequency of intratracheal sputum suctions. All cases avoided aspiration pneumonia. Oral intake was continued for 2-4 years after the tracheostomy and CPL. The satisfaction levels of the patient and primary caregiver were high. CONCLUSION: Our case series suggests that the use of a continuous low-pressure aspirator in patients undergoing CPL improves oral intake and reduces the frequency of intratracheal sputum suctions, which improves the QOL of patients with ALS and their families and caregivers. CPL and continuous low-pressure aspiration should be considered as a management option for ALS with significant bulbar and respiratory muscle weakness/dysfunction.

  41. つながる:咽頭から食道へ-UES/食道の生理・評価・応用- 咽頭と食道の関連 嚥下に関わる「構造の連続性」と「運動の相違」

    香取 幸夫, 平野 愛

    日本摂食・嚥下リハビリテーション学会雑誌　25　(3)　S32-S32　2021年12月

    出版者・発行元： (一社)日本摂食嚥下リハビリテーション学会

    ISSN：1343-8441

    eISSN：2434-2254

  42. 小動物用嚥下造影装置を用いた亜鉛欠乏モデルマウスの嚥下機能解析

    小柴 康利, 戸塚 大幾, 平野 愛, 香取 幸夫

    日本摂食・嚥下リハビリテーション学会雑誌　25　(3)　S84-S84　2021年12月

    出版者・発行元： (一社)日本摂食嚥下リハビリテーション学会

    ISSN：1343-8441

    eISSN：2434-2254

  43. 嚥下内視鏡検査による筋ジストロフィー患者の肺炎発症のリスク評価

    神林 友紀, 平野 愛, 太田 淳, 大村 悠, 由利 博美, 高橋 俊明, 武田 篤, 香取 幸夫

    日本摂食・嚥下リハビリテーション学会雑誌　25　(3)　S105-S105　2021年12月

    出版者・発行元： (一社)日本摂食嚥下リハビリテーション学会

    ISSN：1343-8441

    eISSN：2434-2254

  44. 片側性声帯麻痺患者の喉頭枠組み術前後での発話音声機能を評価するための音読課題と評価指標に関する検討

    佐藤 剛史, 苅安 誠, 渡邊 健一, 本蔵 陽平, 平野 愛, 鹿島 和孝, 香取 幸夫

    音声言語医学　62　(4)　305-313　2021年10月

    出版者・発行元： 日本音声言語医学会

    ISSN：0030-2813

    eISSN：1884-3646

  45. 片側性声帯麻痺患者に対しての発話評価の意義 文章音読課題による休止区間の頻度と時間的解析での術前後比較

    佐藤 剛史, 苅安 誠, 本蔵 陽平, 平野 愛, 鹿島 和孝, 渡邊 健一, 香取 幸夫

    言語聴覚研究　18　(3)　170-170　2021年9月

    出版者・発行元： (一社)日本言語聴覚士協会

    ISSN：1349-5828

  46. 多系統萎縮症における嚥下スクリーニング検査の有用性について

    平野 愛, 大村 悠, 馬場 徹, 武田 篤, 香取 幸夫

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集　15回　108-108　2021年7月

    出版者・発行元： Movement Disorder Society of Japan (MDSJ)

  47. Changes in tongue pressure and dysphagia at oral cancer patients by palatal augmentation prosthesis

    Kuniyuki, I., Hisaoka, T., Ikeda, R., Suzuki, J., Sato, N., Tagaino, R., Kambayashi, T., Hirano-Kawamoto, A., Ohta, J., Ohkoshi, A., Ishii, R., Shitraishi, N., Kato, K., Koyama, S., Sasaki, K., Katori, Y.

    Cancer Reports　2021年

    DOI： 10.1002/cnr2.1516 　

    ISSN：2573-8348

  48. Questionnaire survey on pharyngolaryngeal sensation evaluation regarding dysphagia in Japan

    Kambayashi, T., Kato, K., Ikeda, R., Suzuki, J., Honkura, Y., Hirano-Kawamoto, A., Ohta, J., Kagaya, H., Inoue, M., Hyodo, M., Omori, K., Suehiro, A., Okazaki, T., Izumi, S.-I., Koyama, S., Sasaki, K., Kumai, Y., Nito, T., Kuriyama, S., Ogawa, T., Katori, Y.

    Auris Nasus Larynx　48　(4)　2021年

    DOI： 10.1016/j.anl.2021.01.022 　

    ISSN：1879-1476 0385-8146

  49. Questionnaire survey on nurses and speech therapists regarding dysphagia rehabilitation in Japan

    Kato, K., Ikeda, R., Suzuki, J., Hirano-Kawamoto, A., Kamakura, Y., Fujiu-Kurachi, M., Hyodo, M., Izumi, S.-I., Koyama, S., Sasaki, K., Nakajima, J., Karaho, T., Kimura, Y., Kumai, Y., Fujimoto, Y., Nito, T., Oku, Y., Kurosawa, H., Kuriyama, S., Katori, Y.

    Auris Nasus Larynx　48　(2)　2021年

    DOI： 10.1016/j.anl.2020.08.004 　

    ISSN：1879-1476 0385-8146

  50. Characteristics of aspiration pneumonia patients in acute care hospitals: A multicenter, retrospective survey in Northern Japan

    Suzuki, J., Ikeda, R., Kato, K., Kakuta, R., Kobayashi, Y., Ohkoshi, A., Ishii, R., Hirano-Kawamoto, A., Ohta, J., Kawata, R., Kanbayashi, T., Hatano, M., Shishido, T., Miyakura, Y., Ishigaki, K., Yamauchi, Y., Nakazumi, M., Endo, T., Tozuka, H., Kitaya, S., Numano, Y., Koizumi, S., Saito, Y., Unuma, M., Hashimoto, K., Ishida, E., Kikuchi, T., Kudo, T., Watanabe, K., Ogura, M., Tateda, M., Sasaki, T., Ohta, N., Okazaki, T., Katori, Y.

    PLoS ONE　16　(7 July)　2021年

    DOI： 10.1371/journal.pone.0254261 　

    ISSN：1932-6203

  51. Oral reading task with selected indices to evaluate speaking voice function in patients with unilateral vocal fold paralysis before and after surgical interventions

    Takeshi Sato, Makoto Kariyasu, Kenichi Watanabe, Yohei Honkura, Ai Hirano, Kazutaka Kashima, Yukio Katori

    Japan Journal of Logopedics and Phoniatrics　62　(4)　305-313　2021年

    出版者・発行元： Japan Society of Logopedics and Phoniatrics

    DOI： 10.5112/JJLP.62.305 　

    ISSN：0030-2813

  52. 摂食・嚥下センター外来における医科歯科連携と5年間の治療実績

    池田 怜吉, 平野 愛, 香取 幸夫

    耳鼻咽喉科臨床 補冊　(補冊155)　112-112　2020年12月

    出版者・発行元： 耳鼻咽喉科臨床学会

    ISSN：0912-1870

    eISSN：2185-1557

  53. 頭頸部癌化学放射線治療前後の嚥下評価方法の検証 嚥下内視鏡・造影検査の経時比較

    石井 亮, 加藤 健吾, 大越 明, 佐藤 剛史, 平野 愛, 小川 武則, 香取 幸夫

    口腔・咽頭科　33　(3)　175-175　2020年8月

    出版者・発行元： 日本口腔・咽頭科学会

    ISSN：0917-5105

    eISSN：1884-4316

  54. Characteristics of the Voice Handicap Index for Patients With Unilateral Vocal Fold Paralysis Who Underwent Arytenoid Adduction. 国際誌 査読有り

    Kenichi Watanabe, Takeshi Sato, Yohei Honkura, Ai Kawamoto-Hirano, Kazutaka Kashima, Yukio Katori

    Journal of voice : official journal of the Voice Foundation　34　(4)　649.e1-649.e6　2020年7月

    DOI： 10.1016/j.jvoice.2018.12.012 　

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    PURPOSE: This study was performed to evaluate the characteristics of the Voice Handicap Index (VHI), a self-assessment measure, for patients with unilateral vocal fold paralysis (UVFP) who underwent arytenoid adduction (AA), in comparison with postoperative vocal function examinations. METHODS: A retrospective chart review was conducted for patients who underwent AA at Tohoku University Hospital during the period between 2014 and 2017. VHI was compared before and after surgery; moreover, correlations were assessed between the VHI and other voice measurements, including perceptual assessment of voice, as well as aerodynamic and acoustic measures. Factors involved in the VHI score were explored by multivariate analysis. RESULTS: Forty-three UVFP patients (28 males, age 32-81 years; 15 females, age 34-80 years) were enrolled in the study; the average age of all patients was 61.5 years (32-81 years). Among the enrolled patients, 33 (76.7%) left and 10 (23.3%) right vocal folds were impaired. After surgery, nearly all of the patients exhibited significantly improved VHI score; each of the three subscales (functional, physical, and emotional) was also improved. The postoperative VHI correlated mildly with several values of the other voice measurements, with the exception of the mean flow rate. Multivariate analysis showed that the sole variable associated with postoperative VHI score was preoperative VHI. CONCLUSIONS: The postoperative VHI likely reflects improvement in the voices of the patients with UVFP. Although there were weak correlations with other voice measures, postoperative VHI is a relatively independent measurement parameter for patients with UVFP who underwent AA.

  55. Simultaneous evaluation of symptoms, swallowing functions, and patient-reported swallowing difficulties and their correlations with ingestion status during definitive chemoradiotherapy for oropharyngeal and hypopharyngeal cancer. 国際誌 査読有り

    Ryo Ishii, Kengo Kato, Akira Ohkoshi, Takeshi Sato, Ai Hirano, Takenori Ogawa, Yukio Katori

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer　29　(2)　955-964　2020年6月16日

    DOI： 10.1007/s00520-020-05570-2 　

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    PURPOSE: To clarify the correlations among symptoms, swallowing functions, and ingestion status and to validate a method of swallowing evaluation during chemoradiotherapy (CRT) for head and neck cancer. METHODS: Oropharyngeal and hypopharyngeal cancer patients who were to receive definitive CRT as initial treatment were included in this prospective, single-center, observational study. The Functional Oral Intake Scale (FOIS) for ingestion status and grades of symptoms (dryness, dysgeusia, mucositis, and the analgesic ladder); the Yale Pharyngeal Residue Severity Rating Scale on fiberoptic endoscopic evaluation of swallowing (FEES) and the Penetration-Aspiration Scale (PAS) on videofluoroscopic (VF) evaluation for swallowing functions; and the 10-item Eating Assessment Tool (EAT-10) questionnaire were assessed at 5 time points unless the participant refused. The FEES and VF evaluation findings at each point were also compared. RESULTS: There were 38 participants. Dysgeusia, mucositis, and pain grade, as well as the FOIS score, were the worst at 70 Gy and then improved after treatment. The improvements of pharyngeal residue and the PAS after treatment were limited. The EAT-10 and the pain ladder were highly correlated with the FOIS changes at many time points. The VF evaluation rate dropped after 40 Gy, whereas the FEES rate remained high. There were good correlations between pharyngeal residue and the PAS at 0 Gy, 70 Gy, and 3 months. CONCLUSION: The EAT-10 and pain reflected the FOIS score changes well, while two swallowing evaluations did not. To avoid aspiration, VF evaluation may not be necessary during CRT because of high correlations with pharyngeal residue on FEES.

  56. 声帯麻痺症例の検討

    長谷川 航世, 渡邊 健一, 本藏 陽平, 鹿島 和孝, 平野 愛, 佐藤 剛史, 香取 幸夫

    喉頭　31　(2)　163-167　2019年12月

    出版者・発行元： 日本喉頭科学会

    ISSN：0915-6127

    eISSN：2185-4696

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    当院で経験した声帯麻痺168例を検討した。その結果、平均年齢は62.0歳で、男性104例、女性64例であった。患側は左107例、右37例、両側24例であった。原因は腫瘍性が65例と最多で、心臓大血管性44例、特発性21例、挿管性16例の順であった。経過観察中に32例(19.0%)で声帯麻痺の回復がみられ、回復に要した期間は平均3.6ヵ月であった。原因別では挿管性で麻痺の回復率が高かった。片側声帯麻痺の回復を認めなかった61例中37例で音声改善手術が行われたが、術式は披裂軟骨内転術+甲状軟骨形成術1型が36例、甲状軟骨形成術1型が1例であった。音声治療は12例で行われ、それぞれ6例が麻痺回復し、6例が麻痺回復せず、うち2例に音声改善手術が施行されていた。

  57. 【私はこうしている-口腔咽喉頭頸部手術編】嚥下障害の手術 誤嚥防止術 狭域の喉頭摘出術

    加藤 健吾, 平野 愛, 香取 幸夫

    JOHNS　35　(9)　1365-1368　2019年9月

    出版者・発行元： (株)東京医学社

    ISSN：0910-6820

  58. 【嚥下障害と誤嚥性肺炎】嚥下障害に対する対応 嚥下障害の手術治療

    香取 幸夫, 加藤 健吾, 平野 愛

    Clinical Neuroscience　37　(5)　586-589　2019年5月

    出版者・発行元： (株)中外医学社

    ISSN：0289-0585

  59. 輪状軟骨後板を温存した喉頭中央部切除術変法の長期予後の検討

    加藤 健吾, 平野 愛, 香取 幸夫

    日本耳鼻咽喉科学会会報　122　(4)　669-669　2019年4月

    出版者・発行元： (一社)日本耳鼻咽喉科学会

    ISSN：0030-6622

    eISSN：1883-0854

  60. 新しい誤嚥防止手術 輪状軟骨を温存した喉頭中央部切除術変法

    加藤 健吾, 平野 愛, 香取 幸夫

    日本気管食道科学会会報　70　(2)　s5-s5　2019年4月

    出版者・発行元： (NPO)日本気管食道科学会

    ISSN：0029-0645

    eISSN：1880-6848

  61. 早期喉頭癌に対し行われた経口的腫瘍切除術の治療成績

    舘田 豊, 渡邊 健一, 清水 佑一, 橋本 光, 白倉 真之, 太田 淳, 平野 愛, 本藏 陽平, 鈴木 淳, 小川 武則, 香取 幸夫

    日本耳鼻咽喉科学会会報　122　(4)　707-707　2019年4月

    出版者・発行元： (一社)日本耳鼻咽喉科学会

    ISSN：0030-6622

    eISSN：1883-0854

  62. ゴアテックスを使用した甲状軟骨形成術1型の術後合併症

    渡邊 健一, 平野 愛, 本藏 陽平, 鹿島 和孝, 白倉 真之, 香取 幸夫

    日本気管食道科学会会報　70　(2)　s31-s31　2019年4月

    出版者・発行元： (NPO)日本気管食道科学会

    ISSN：0029-0645

    eISSN：1880-6848

  63. 症例をどうみるか 咬筋内に発生した静脈性血管瘤の1例

    平野 愛, 渡邊 健一, 香取 幸夫

    JOHNS　35　(1)　119-122　2019年1月

    出版者・発行元： (株)東京医学社

    ISSN：0910-6820

    詳細を見る 詳細を閉じる

    37歳女。右頬部腫瘤を主訴とした。頸部MRIにて右咬筋内に径20×10mmの境界明瞭な腫瘤影を認めた。T2強調画像では高信号な腫瘤内部に低信号の箇所を含み、T1強調画像では筋と等信号な箇所を主体とし、一部高信号な箇所を含んでいた。保存的に経過観察後、腫瘤の増大傾向を認め、手術を行い、腫瘤病変の周囲を剥離し、摘出した。病理学的検査では内腔を器質化した血栓を伴う拡張した静脈を認め、その近傍には変性した血液とEM染色で緑色に染色された膠原線維の同心円状の堆積からなる充実性腫瘤が認められた。以上より、器質化した血栓をともなう静脈性血管瘤と診断した。術後は良好で、合併症は認めず、術後4日目に退院し、術後3ヵ月の時点で再発は認めなかった。

  64. Complications of using Gore-Tex in medialization laryngoplasty: case series and literature review. 国際誌 査読有り

    Kenichi Watanabe, Ai Hirano, Yohei Honkura, Kazutaka Kashima, Masayuki Shirakura, Yukio Katori

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery　276　(1)　255-261　2019年1月

    DOI： 10.1007/s00405-018-5204-0 　

    詳細を見る 詳細を閉じる

    PURPOSE: This study was performed to evaluate the incidence and contributing factors of complications associated with medialization laryngoplasty using Gore-Tex in patients with unilateral vocal fold paralysis. METHODS: A retrospective chart review was conducted for all patients who underwent medialization laryngoplasty using Gore-Tex at Tohoku University Hospital between January 2014 and April 2018. A search of series and case reports in PubMed was performed to determine the incidence of complications following medialization laryngoplasty using Gore-Tex. RESULTS: Sixty-eight patient charts were reviewed. Two patients (2.9%) had complications (infection and extrusion into the airway) related to the Gore-Tex implant after surgery. In the 555 medialization laryngoplasty cases reported in both our current data and eight additional articles, there were 11 complications related to the Gore-Tex implant (2.0%). The most common event was extrusion into the lumen, which occurred in six cases (1.1%), followed by persistent inflammation with the granulation formation (0.5%). There were 12 cases of Gore-Tex extrusion (one male, six female, and five of unknown gender). The interval to onset ranged from 1 month to 10 years (median, 49 months). CONCLUSIONS: Our findings serve as a reminder that complications can occur with Gore-Tex implants following medialization laryngoplasty in patients with unilateral vocal fold paralysis, even in the long-term. We suggest that the use of excessively large implants in women and occurrence of postoperative hematoma followed by infection are factors that may cause complications. Nevertheless, Gore-Tex has been proven to be a relatively safe and reliable material for medialization laryngoplasty.

  65. 気管食道吻合術後に声帯発声を認めた一例

    戸塚 大幾, 加藤 健吾, 佐藤 剛史, 北谷 栞, 平野 愛, 香取 幸夫

    日本摂食・嚥下リハビリテーション学会雑誌　22　(3)　S128-S128　2018年12月

    出版者・発行元： (一社)日本摂食嚥下リハビリテーション学会

    ISSN：1343-8441

    eISSN：2434-2254

  66. 当院における摂食嚥下機能評価の取り組みについて

    逸見 朋隆, 小倉 正樹, 山崎 宗治, 舘田 豊, 平野 愛, 香取 幸夫

    仙台市立病院医学雑誌　38　9-13　2018年10月

    出版者・発行元： 仙台市立病院

    ISSN：0388-8878

  67. 嚥下障害への対応Up to Date 頭頸部癌治療にともなう嚥下障害への治療戦略

    石井 亮, 加藤 健吾, 平野 愛, 佐藤 剛史, 大越 明, 小川 武則, 松浦 一登, 香取 幸夫

    口腔・咽頭科　31　(3)　238-238　2018年8月

    出版者・発行元： 日本口腔・咽頭科学会

    ISSN：0917-5105

    eISSN：1884-4316

  68. 耳鼻咽喉科診療up to date 嚥下障害の治療 診療科連携、手術、誤嚥の検出と防止への取り組み

    香取 幸夫, 加藤 健吾, 平野 愛

    耳鼻咽喉科臨床 補冊　(補冊153)　50-50　2018年6月

    出版者・発行元： 耳鼻咽喉科臨床学会

    ISSN：0912-1870

    eISSN：2185-1557

  69. Poor oral intake causes enteral nutrition dependency after concomitant chemoradiotherapy for pharyngeal cancers. 国際誌 査読有り

    Ryo Ishii, Kengo Kato, Takenori Ogawa, Takeshi Sato, Ayako Nakanome, Akira Ohkoshi, Ai Kawamoto-Hirano, Masayuki Shirakura, Hiroshi Hidaka, Yukio Katori

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery　275　(6)　1607-1611　2018年6月

    DOI： 10.1007/s00405-018-4963-y 　

    詳細を見る 詳細を閉じる

    PURPOSE: To identify precipitating factors responsible for enteral nutrition (EN) dependency after concomitant chemoradiotherapy (CCRT) of head and neck cancers and to examine their statistical correlations. METHODS: Factors related to feeding condition, nutritional status, disease, and treatment of 26 oropharyngeal and hypopharyngeal cancer patients who received definitive CCRT were retrospectively investigated by examining their medical records. The days of no oral intake (NOI) during hospitalization and the months using enteral nutrition after CCRT were counted as representing the feeding condition, and the changes in body weight (BW) were examined as reflecting nutritional status. The factors related to EN dependency after CCRT were analyzed. RESULTS: Long duration of total NOI (≥ 30 days) and maximum NOI ≥ 14 days were significant predictors of EN dependency. Decreased BW (≥ 7.5 kg) was the next predictor identified, but it was not significant. Multivariate analysis showed that the total duration of NOI was more correlated with EN dependency than changes in BW. CONCLUSIONS: A long duration of NOI was more strongly related to EN dependency than nutritional factors.

  70. 当院における摂食嚥下機能評価の取り組みについて

    逸見 朋隆, 小倉 正樹, 山崎 宗治, 舘田 豊, 平野 愛, 香取 幸夫

    音声言語医学　59　(1)　58-58　2018年1月

    出版者・発行元： 日本音声言語医学会

    ISSN：0030-2813

    eISSN：1884-3646

  71. 喉頭形成術がもたらす音声障害患者の心理的側面およびQOLへの効果

    平野 愛, 渡邊 健一, 佐藤 剛史, 本蔵 陽平, 香取 幸夫

    音声言語医学　59　(1)　52-52　2018年1月

    出版者・発行元： 日本音声言語医学会

    ISSN：0030-2813

    eISSN：1884-3646

  72. 食道における腸管神経の分布 高齢者のご遺体を用いた免疫組織化学的研究

    香取 幸夫, 本蔵 陽平, 平野 愛

    嚥下医学　6　(2)　261-261　2017年9月

    出版者・発行元： 日本嚥下医学会

    ISSN：2186-3199

  73. 誤嚥防止を目的とする狭域の喉頭摘出術 喉頭中央部切除術

    香取 幸夫, 平野 愛, 加藤 健吾

    嚥下医学　6　(2)　261-262　2017年9月

    出版者・発行元： 日本嚥下医学会

    ISSN：2186-3199

  74. 頭頸部癌化学放射線療法中の経口摂取中止および嚥下機能の胃瘻依存への影響

    石井 亮, 加藤 健吾, 佐藤 剛史, 大石 哲也, 本藏 陽平, 白倉 真之, 小林 祐太, 原 陽介, 平野 愛, 鹿島 和孝, 香取 幸夫

    嚥下医学　6　(2)　248-249　2017年9月

    出版者・発行元： 日本嚥下医学会

    ISSN：2186-3199

  75. 頭頸部癌根治的化学放射線療法における舌根-咽頭後壁間距離の変化と絶食期間、照射後嚥下障害との関係

    加藤 健吾, 石井 亮, 佐藤 剛史, 大石 哲也, 本藏 陽平, 原 陽介, 白倉 真之, 小林 祐太, 鹿島 和孝, 平野 愛, 香取 幸夫

    嚥下医学　6　(2)　249-249　2017年9月

    出版者・発行元： 日本嚥下医学会

    ISSN：2186-3199

  76. 深頸部膿瘍排膿術後に嚥下機能回復が遅延する因子に関する検討(第2報)

    日高 浩史, 小澤 大樹, 平野 愛, 渡邊 健一, 香取 幸夫

    日本耳鼻咽喉科学会会報　120　(4)　581-581　2017年4月

    出版者・発行元： (一社)日本耳鼻咽喉科学会

    ISSN：0030-6622

    eISSN：1883-0854

  77. 誤嚥防止術としての喉頭中央部分切除術の有効性の検証

    加藤 健吾, 平野 愛, 逸見 朋隆, 渡邉 幸二郎, 小倉 正樹, 本藏 陽平, 石井 亮, 大石 哲也, 香取 幸夫

    日本耳鼻咽喉科学会会報　120　(4)　608-608　2017年4月

    出版者・発行元： (一社)日本耳鼻咽喉科学会

    ISSN：0030-6622

    eISSN：1883-0854

  78. Enteric neurons of the esophagus: an immunohistochemical study using donated elderly cadavers

    Hirano-Kawamoto, A., Honkura, Y., Kobayashi, Y., Murakami, G., Abe, S.-I., Katori, Y.

    Surgical and Radiologic Anatomy　39　(5)　2017年

    DOI： 10.1007/s00276-016-1799-2 　

    ISSN：1279-8517 0930-1038

  79. 音声障害症例に関するHADSを用いた心理的評価に影響する要因についての検討

    佐藤 剛史, 渡邊 健一, 本蔵 陽平, 太田 淳, 平野 愛, 小林 祐太, 香取 幸夫

    音声言語医学　58　(1)　74-74　2017年1月

    出版者・発行元： 日本音声言語医学会

    ISSN：0030-2813

    eISSN：1884-3646

  80. 声帯萎縮症における吸入ステロイド薬使用例の検討

    渡邊 健一, 本蔵 陽平, 平野 愛, 太田 淳, 小林 祐太, 佐藤 剛史, 香取 幸夫

    音声言語医学　58　(1)　87-88　2017年1月

    出版者・発行元： 日本音声言語医学会

    ISSN：0030-2813

    eISSN：1884-3646

  81. Nasolacrimal duct opening to the inferior nasal meatus in human fetuses. 査読有り

    Yohei Honkura, Yoshitaka Takanashi, Ai Kawamoto-Hirano, Hiroshi Abe, Hajime Osanai, Gen Murakami, Yukio Katori

    Okajimas folia anatomica Japonica　94　(3)　101-108　2017年

    DOI： 10.2535/ofaj.94.101 　

    詳細を見る 詳細を閉じる

    The purpose of this study is to describe the Hasner's membrane which is the main factor of congenital nasolacrimal duct obstruction. Hasner's membrane at the nasal end of the fetal nasolacrimal duct (NLD) is considered to rupture at and after birth. However, topographical anatomy around the membrane as well as a mechanism of rupture seems to be still obscure. We observed frontal or sagittal sections of 20 late-stage fetuses (28-33 weeks) and found the on-going rupture in 2 specimens. The present sections demonstrated that 1) the nasal dilation was not a simple ball-like structure but extended posteriorly and laterally; 2) dilation of the NLD consistently involved the lacrimal sac; 3) Hasner's membrane and ductal mucosal layer contained no macrophages and no or few arteries and nerves. The posterior extension of the NLD end ranged from 1-2 mm, while the lateral extension 3-5 mm although a site of the thinnest membrane varied in location between specimens. Moreover, the thickest NLD due to dilation was in the slightly orbital or upper side of the nasal end. Therefore, before surgical treatment of Hasner's membrane, evaluation using medical images seems to be necessary. Since the nasal epithelium on Hasner's membrane was most likely to destroy earlier than the NLD mucosal lining, observations of the membrane from the nasal cavity seemed helpful for diagnosis at which site would be broken and when.

  82. 深頸部膿瘍・降下性縦隔炎罹患後の重度嚥下障害 頸部のマッサージと舌骨・喉頭の他動運動が著効を奏した1例

    佐藤 豊展, 加藤 健吾, 平野 愛, 近藤 健男, 柴本 勇, 香取 幸夫, 出江 紳一

    日本摂食・嚥下リハビリテーション学会雑誌　20　(3)　156-162　2016年12月

    出版者・発行元： (一社)日本摂食嚥下リハビリテーション学会

    ISSN：1343-8441

    eISSN：2434-2254

  83. Submucosal Elastic Laminae of the Middle and Lower Pharynx: A Histological Study Using Elderly Cadaveric Specimens. 国際誌 査読有り

    Ai Kawamoto-Hirano, Yohei Honkura, Masahito Yamamoto, Shin-Ichi Abe, Gen Murakami, Yukio Katori

    Dysphagia　31　(5)　635-43　2016年10月

    DOI： 10.1007/s00455-016-9721-y 　

    詳細を見る 詳細を閉じる

    Although the pharyngeal wall is well known to have high elasticity, the distribution of submucosal elastic fibers has not been described. Observations of histological sections of the mid and lower pharyngeal walls from 15 elderly donated cadavers were made. We found two distinct submucosal tissue layers with a high content of elastic fibers (tentatively termed the "submucosal elastic laminae"). The inferolateral elastic lamina was restricted to the level from the upper part of the arytenoid to the lower end of the inferior cornu of the thyroid cartilage. It originated from the pharyngeal submucosa, extended laterally along the inner aspect of the thyropharyngeal muscle, and inserted into the posterior margin of the thyroid cartilage including the cornu. The posteromedial lamina extended along the supero-inferior axis from a level above the greater horn of the hyoid bone to reach the muscularis mucosae of the cervical esophagus. The inferolateral and posteromedial laminae were connected at levels below the cricoarytenoid joint. Individual variations were evident in their thicknesses (ranging from almost absent to 0.3 mm) as well as the extent of connection between them. In association with striated muscle function, the inferolateral lamina seemed to suspend the lower pharyngeal mucosa, while the posteromedial lamina seemed to provide mucosal fold forcing smoothly peristaltic conveyance of a bolus during swallowing.

  84. 音声障害患者における心理的要因の関連についての検討

    佐藤 剛史, 渡邊 健一, 高梨 芳崇, 本蔵 陽平, 平野 愛, 太田 淳, 川瀬 哲明, 香取 幸夫

    言語聴覚研究　13　(3)　147-147　2016年9月

    出版者・発行元： (一社)日本言語聴覚士協会

    ISSN：1349-5828

  85. Cricothyroid Articulation in Elderly Japanese With Special Reference to Morphology of the Synovial and Capsular Tissues. 国際誌 査読有り

    Ai Kawamoto, Yohei Honkura, Ryoji Suzuki, Hiroshi Abe, Shin-Ichi Abe, Gen Murakami, Yukio Katori

    Journal of voice : official journal of the Voice Foundation　30　(5)　538-48　2016年9月

    DOI： 10.1016/j.jvoice.2015.07.011 　

    詳細を見る 詳細を閉じる

    OBJECTIVE: The present study aimed to clarify individual variations in the cricothyroid joint (CT joint). METHODS: Using 30 specimens of the CT joint obtained from elderly donated cadavers, we examined the composite fibers of the capsular ligament as well as the morphology of the synovial tissue. RESULTS: The capsular ligament consistently contained abundant thick elastic fiber bundles on the anterior side of the joint (anterior band) and an elastic fiber-made mesh on the posterior side (posterior mesh). The synovial membrane, lined by synovial macrophages, was usually restricted to the recesses in the medial or inferior end of the joint cavity. Without the synovial lining, elastic fibers of the capsular ligament were subsequently detached, dispersed, and exposed to the joint cavity. We also observed a folded and thickened synovial membrane and a hypertrophic protrusion of the capsular ligament. In six specimens, the joint cavity was obliterated by debris of synovial folds and elastic fiber-rich tissues continuous with the usual capsular ligament. Notably, with the exception of two specimens, we did not find lymphocyte infiltration in the degenerative synovial tissue. DISCUSSION: We considered the CT joint degeneration to be a specific, silent form of osteoarthritis from the absence of lymphocyte infiltration. For high-pitched phonation, the elderly CT joint seemed to maintain its anterior gliding and rotation with the aid of elastic fiber-rich tissues compensating for the loss of congruity between the joint cartilage surfaces. Conversely, however, high-pitched phonation may accelerate obliteration of the joint.

  86. The cricothyroid joint in elderly Japanese individuals. 査読有り

    Masamitu Serikawa, Masahito Yamamoto, Ai Kawamoto, Yukio Katori, Hideaki Kinoshita, Satoru Matsunaga, Shin-Ichi Abe

    Anatomical science international　91　(3)　250-7　2016年6月

    DOI： 10.1007/s12565-015-0294-x 　

    詳細を見る 詳細を閉じる

    Using 15 cricothyroid joint (CT joint) specimens obtained from donated cadavers of elderly individuals, we examined the morphologies of the ceratocricoid ligaments as well as the synovial tissue. The ligaments consistently contained abundant elastic fibers: the fibers tended to be straight on the anterior side in contrast to a mesh-like arrangement on the posterior side. Thick and/or long synovial folds were often evident in the CT joint. The synovial tissue usually contained CD68-positive macrophages, but the positive cells were often restricted to certain parts of the tissue. Factor VIII-positive capillaries were present but few in number, and CD3- or IgM-positive lymphocytes were absent in the synovial tissue. Degenerative changes in the joint cartilage, such as roughness or thinning, were often present, but no cartilage defects were evident. Therefore, in contrast to the small, non-weight-bearing joints of the musculoskeletal system, we considered the degeneration of the CT joint to be a specific, silent form of osteoarthritis. For high-pitched phonation and ossification of the laryngeal cartilage, the CT joint in elderly individuals seemed to maintain its anterior gliding and rotation with the aid of elastic fiber-rich tissues compensating for the loss of congruity between the joint cartilage surfaces.

  87. 小児深頸部膿瘍における成人例の違いに関する検討

    日高 浩史, 小澤 大樹, 平野 愛, 野村 有理, 野口 直哉, 角田 梨紗子, 矢野 寿一, 香取 幸夫

    小児耳鼻咽喉科　37　(2)　151-151　2016年5月

    出版者・発行元： 日本小児耳鼻咽喉科学会

    ISSN：0919-5858

    eISSN：2186-5957

  88. 咽頭癌化学放射線療法における絶食期間および胃瘻離脱困難の検討

    石井 亮, 白倉 真之, 平野 愛, 鹿島 和孝, 東 賢二郎, 大越 明, 中目 亜矢子, 嵯峨井 俊, 加藤 健吾, 小川 武則, 香取 幸夫

    頭頸部癌　42　(2)　183-183　2016年5月

    出版者・発行元： (一社)日本頭頸部癌学会

    ISSN：1349-5747

    eISSN：1881-8382

  89. 気管食道科から次世代リーダーを育成する ご遺体を用いた頭頸部手術手技研修と研究

    香取 幸夫, 小川 武則, 本蔵 陽平, 平野 愛

    日本気管食道科学会会報　67　(2)　90-92　2016年4月

    出版者・発行元： (NPO)日本気管食道科学会

    ISSN：0029-0645

    eISSN：1880-6848

  90. 筋ジストロフィー患者に対する嚥下スクリーニング検査の有用性の検討

    平野 愛, 渡邊 健一, 香取 幸夫

    日本気管食道科学会会報　67　(2)　s73-s73　2016年4月

    出版者・発行元： (NPO)日本気管食道科学会

    ISSN：0029-0645

    eISSN：1880-6848

  91. 壊死性降下性縦隔炎に対する排膿術後の嚥下障害併発に関する検討

    日高 浩史, 小澤 大樹, 平野 愛, 角田 梨紗子, 菅野 景子, 嵯峨井 俊, 渡邊 健一, 香取 幸夫

    日本耳鼻咽喉科学会会報　119　(4)　570-570　2016年4月

    出版者・発行元： (一社)日本耳鼻咽喉科学会

    ISSN：0030-6622

    eISSN：1883-0854

  92. 口腔・咽頭癌治療症例に対する簡易嚥下誘発検査

    香取 幸夫, 加藤 健吾, 渡邊 健一, 石井 亮, 平野 愛, 荒川 一弥, 太田 淳, 中目 亜矢子, 小川 武則

    日本気管食道科学会会報　67　(2)　s2-s2　2016年4月

    出版者・発行元： (NPO)日本気管食道科学会

    ISSN：0029-0645

    eISSN：1880-6848

  93. Cricoarytenoid Articulation in Elderly Japanese With Special Reference to Morphology of the Synovial Tissue. 国際誌 査読有り

    Ai Kawamoto-Hirano, Yohei Honkura, Shunichi Shibata, Shin-ichi Abe, Gen Murakami, Yukio Katori

    The Annals of otology, rhinology, and laryngology　125　(3)　219-27　2016年3月

    DOI： 10.1177/0003489415606450 　

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    OBJECTIVE: To clarify composite fibers and cells in the synovial tissues of the cricoarytenoid joint (CA joint). METHODS: Routine histology and immunohistrochemistry using sagittal or nearly sagittal sections obtained from 18 elderly cadaveric specimens. RESULTS: The CA joint capsule was thin and contained few elastic fibers. A limited supportive ligament, namely, a thickened fascia of the posterior cricoarytenoid muscles, was sometimes evident on the lateral aspect of the CA joint. However, even in the weaker medial aspect of the joint, no marked destruction of the synovial tissues was found. The CA joint always contained synovial folds--a short medial fold and long lateral folds--but these contained no or few macrophages, lymphocytes, and blood capillaries. In 2 exceptional specimens showing inflammatory cell infiltration in the submucosal tissue of the larynx, the macrophage-rich area extended toward the capsule and medial synovial fold. CONCLUSIONS: The lateral aspect of the CA joint was likely to be supported mechanically by the muscle-associated tissues. Strong support of the arytenoid by muscles might reduce the degree of CA joint injury with age. However, some patients with hoarseness due to mucosal inflammation of the larynx might have accompanying synovitis and subsequent cartilage injury in the CA joint.

  94. Macrophage infiltration into thyroid follicles: An immunohistochemical study using donated elderly cadavers

    Takayama, T., Hirano-Kawamoto, Ai, Yamamoto, M., Murakami, G., Katori, Y., Kitamura, K., Abe, S.-I.

    Okajimas Folia Anatomica Japonica　93　(3)　2016年

    DOI： 10.2535/ofaj.93.73 　

    ISSN：1881-1736 0030-154X

  95. 音声障害症例に関するHADSを用いた心理的評価の検討

    佐藤 剛史, 高梨 芳崇, 渡邊 健一, 本蔵 陽平, 平野 愛, 太田 淳, 川瀬 哲明, 香取 幸夫

    音声言語医学　57　(1)　103-104　2016年1月

    出版者・発行元： 日本音声言語医学会

    ISSN：0030-2813

    eISSN：1884-3646

  96. Morphological differences in innervation between mucous glands and serous glands: a quantitative histological study using the sublingual glands of elderly humans. 国際誌 査読有り

    Ai Kawamoto, Kei Kitamura, Masahito Yamamoto, Gen Murakami, Shin-ichi Abe, Yukio Katori

    Acta oto-laryngologica　135　(9)　942-9　2015年9月

    DOI： 10.3109/00016489.2015.1034878 　

    詳細を見る 詳細を閉じる

    CONCLUSION: In the sublingual gland, the serous lobule usually carried a higher density of NSE-positive nerve elements than the mucous lobule, whereas the mucous acinus in the mucous lobule was larger than the serous acinus in the serous lobule. OBJECTIVES: To demonstrate quantitative differences in nerve elements between the mucous and serous lobules of sublingual glands. METHODS: This study investigated using specimens from 14 donated cadavers (mean age = 78 years). Since immunohistochemistry for neuron-specific enolase (NSE) stains all nerves in addition to other mesenchymal cells possibly of nerve origin, the present quantitative evaluation was based on NSE-positive areas per visual field under a ×20 objective lens (0.6 × 0.45 mm when printed). RESULTS: In mucous lobules, the areas occupied by NSE-positive nerve elements ranged from 5798-16,541 μm(2) (mean ± SD = 9280 ± 2584 μm(2)). In contrast, the corresponding areas in serous lobules ranged from 7853-23,540 μm(2) (mean ± SD = 13,520 ± 4351 μm(2)). The difference in NSE-positive areas was statistically significant (p = 0.0022). However, the mucous acinus in the mucous lobule was 2-times larger than the serous acinus in the serous lobule (2474 ± 1477 μm(2) vs 1119 ± 632 μm(2)).

  97. Central-part laryngectomy is a useful and less invasive surgical procedure for resolution of intractable aspiration. 国際誌 査読有り

    Ai Kawamoto, Yukio Katori, Yohei Honkura, Risako Kakuta, Kenjiro Higashi, Masaki Ogura, Makiko Miyazaki, Kazuya Arakawa, Kazutaka Kashima, Yukinori Asada, Kazuto Matsuura

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery　271　(5)　1149-55　2014年5月

    DOI： 10.1007/s00405-013-2725-4 　

    詳細を見る 詳細を閉じる

    A novel narrow-field laryngectomy procedure known as central-part laryngectomy (CPL) for less invasive laryngeal diversion in patients with intractable aspiration is introduced. We conducted retrospective case reviews of 15 patients who underwent CPL. In this procedure, an area of the glottis including the mid-part of the thyroid cartilage and cricoid cartilage is removed to separate the digestive tract from the air way. The lateral part of the thyroid cartilage, the entire hypopharyngeal mucosa and epiglottis are preserved. The superior laryngeal vessels and nerve are not invaded. All fifteen patients were relieved of aspiration without major complications. In good accordance with cutting of the cricopharyngeal muscles and removal of the cricoid cartilage, postoperative videofluoroscopy demonstrated smooth passages of barium. Ten of 12 patients who had hoped to resume oral food intake became able to do so after CPL and two others also achieved partial oral deglutition. CPL is a useful procedure for treatment of intractable aspiration and offers considerable advantages over other laryngotracheal diversion procedures from the view point of oral food intake.

  98. Transsphenoidal meningocele: an anatomical study using human fetuses including report of a case. 国際誌 査読有り

    Yukio Katori, Ai Kawamoto, Kwang Ho Cho, Kiyoshi Ishii, Hiroshi Abe, Shinichi Abe, Jose Francisco Rodríguez-Vázquez, Gen Murakami, Tetsuaki Kawase

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery　270　(10)　2729-36　2013年9月

    DOI： 10.1007/s00405-013-2392-5 　

    詳細を見る 詳細を閉じる

    An asymptomatic transsphenoidal meningoencephalocele was discovered incidentally by fiber laryngoscopic examination in a 62-year-old man suffering from hoarseness due to dysplasia of the vocal cord epithelium. To provide a better understanding of the pathogenesis of this anomaly, we performed histologic observations of paraffin-embedded specimens of 42 human fetal heads at 12-16 weeks of gestation. At these stages, ossification had started in the clivus but the sphenoid sinus was not developed. In contrast to the very low incidence of the intra- or trans-sphenoidal remnant of Rathke's pouch after birth, we found (1) the typical mid-line cleft of the sphenoid body in two specimens (2/42 or 4.8 %) and (2) a duct-like, sellar inferior protrusion ending in the sphenoid body in 12 specimens (12/42 or 28.6 %). The cyst-like structure in the protrusion (two specimens) seemed to be composed of obstructed veins. The intra- and trans-sphenoidal anomalies were observed more frequently in specimens without ossification of the sphenoid body than in those with ossification. However, irrespective of ossification, a cyst-like remnant of the most upper part of Rathke's pouch was always seen between the anterior and posterior lobes of the developing pituitary gland. In addition, the bursa pharyngea was seen in four specimens and we confirmed that the notochord was attached to the bursa in each case. The consistent remnant of the intrasellar Rathke's pouch appeared to explain the high incidence of Rathke's cleft cyst in adults. The relatively high incidence of intrasphenoidal anomalies in fetuses (14/42) suggested that the intra- or trans-sphenoidal remnant of Rathke's pouch was physiologically closed by ossification of the sphenoid body.

  99. Osseous hamartoma arising from the eustachian tube. 国際誌 査読有り

    Ai Kawamoto, Yukio Katori, Yohei Honkura, Masaki Ogura, Takeshi Oshima, Toshimitsu Kobayashi

    Clinics and practice　3　(2)　e25　2013年8月2日

    DOI： 10.4081/cp.2013.e25 　

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    A fairly quite rare case of osseous tumor arising from the Eustachian tube (ET) is described. A 56-year-old man presented with a smooth bulky mass in the nasopharynx and secretory otitis media in the right ear. Computed tomography and magnetic resonance imaging indicated a solid tumor-like region occupying the nasopharynx with apparent extension to the right ET. Transnasal endoscopic surgery demonstrated that the tumor had originated from the ET, and the tumor was partially removed in the area where it had expanded into the nasopharynx. The pathological diagnosis was an osseous hamartoma consisting of bony tissue, fat cells and fibroblasts. To our knowledge, this is the first reported case of osseous hamartoma arising from the ET in the world literature. The patient presented symptoms of nasal obstruction and unilateral aural fullness. Reduction surgery and tympanostomy tube insertion were useful for accurate diagnosis and resolution of the symptoms.

  100. Isolated juvenile xanthogranuloma in the larynx of a three-year-old child. 査読有り

    Ai Kawamoto, Yukio Katori, Yohei Honkura, Keiko Ishii, Masaki Ogura, Hiroshi Naganuma, Rie Shibuya, Takahiro Suzuki, Toshimitsu Kobayashi

    The Tohoku journal of experimental medicine　230　(2)　123-7　2013年6月

    eISSN：1349-3329

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    Juvenile xanthogranuloma (JXG) is a benign manifestation of non-Langerhans cell histiocytosis characterized by yellowish cutaneous nodules. Its occurrence in the larynx is very rare, but laryngeal JXG may cause severe respiratory distress. We report a patient with isolated laryngeal JXG treated by laryngomicrosurgery, and this is the first report of JXG extending to vocal fold. A 3-year-old girl presented with hoarseness and inspiration stridor. A bulky tumor was found in right glottic to subglottic region. Subtotal resection of the tumor was carried out by laryngomicrosurgery, and airway distress was diminished after the operation. In pathological examination, the resected specimen showed proliferation of histiocytic cells and spindle cells with Touton giant cells that are characterized by polynuclei or wreath nuclei and are known to appear in JXG but not in LCH. Immunohistochemistry of histiocytic cell markers demonstrated positivity for CD68, lysozyme, alpha1-anti-chymotrypsin, factor XIIIa and vimentin, and negativity for CD1a and S-100, leading to diagnosis of JXG, but not LCH. The patient was thus expected with benign prognosis, and additional resection of the tumor including vocal fold was not indicated in the initial treatment. Six weeks later, the JXG recurred and a second procedure using CO₂ laser was needed. The tumor did not re-grow thereafter, and there was no residual voice handicap. Because of its favorable prognosis and tendency for spontaneous regression, JXG in the larynx needs to be considered carefully with regard to whether reduction surgery and/or tracheotomy are necessary, and thus precise diagnosis is required.

  101. Acquired idiopathic laryngomalacia treated by laser supraglottic laryngoplasty. 査読有り

    Ai Kawamoto, Yukio Katori, Yohei Honkura, Masaki Ogura, Yoshitaka Takanashi, Toshimitsu Kobayashi

    The Tohoku journal of experimental medicine　230　(1)　43-7　2013年5月

    eISSN：1349-3329

    詳細を見る 詳細を閉じる

    Laryngomalacia is the most common cause of stridor in neonates and infants, where the soft cartilages and tissues surrounding the upper larynx collapse inward during respiration. On the other hand, acquired idiopathic laryngomalacia in adults is quite rare, but should be borne in mind for differential diagnosis of upper airway distress. Allergic factors may cause airway distress, but have not been highlighted previously as the background of laryngomalacia. In this report, we describe two patients with acquired idiopathic laryngomalacia with reference to allergic rhinitis and high serum levels of immunoglobulin E. The first patient was a 16-year-old female who presented with inspiratory stridor and dyspnea due to attachment between the epiglottis and bilateral arytenoids, and the second patient was an 18-year-old male who also presented with inspiratory stridor due to attachment between the epiglottis and posterior pharyngeal wall. The respiratory function of both patients was within the normal range but the inspiratory stridor interfered with daily life. Laryngomicrosurgery was performed in both patients using a CO2 laser to remove the arytenoid mucosa in the first patient, and to remove the tip of the epiglottis in the second. Both patients were followed up while receiving oral anti-allergic agents. Laser supraglottic laryngoplasty to remove the vibrating excess tissue was effective for resolving the symptoms. However, recurrence occurred three times in the first patient, and inferior turbinotomy to improve nasal respiration was useful for diminishing the symptoms.

︎全件表示 ︎最初の5件までを表示

MISC 20

  1. 嚥下障害を主徴とする封入体筋炎の2例

    鈴木 直輝, 金子 仁彦, 井泉 瑠美子, 太田 淳, 平野 愛, 青木 正志, 海老原 覚, 香取 幸夫

    日本摂食・嚥下リハビリテーション学会雑誌　29　(3)　S122-S122　2025年12月

    出版者・発行元： (一社)日本摂食嚥下リハビリテーション学会

    ISSN： 1343-8441

    eISSN： 2434-2254

  2. 嚥下障害を主徴とする封入体筋炎の2例

    鈴木 直輝, 金子 仁彦, 井泉 瑠美子, 太田 淳, 平野 愛, 青木 正志, 海老原 覚, 香取 幸夫

    日本摂食・嚥下リハビリテーション学会雑誌　29　(3)　S122-S122　2025年12月

    出版者・発行元： (一社)日本摂食嚥下リハビリテーション学会

    ISSN： 1343-8441

    eISSN： 2434-2254

  3. 輪状咽頭筋切開術の際の筋検体で診断し得た、嚥下障害のみを呈する封入体筋炎の1例

    金子 仁彦, 井泉 瑠美子, 鈴木 直輝, 太田 淳, 平野 愛, 香取 幸夫, 青木 正志

    日本筋学会学術集会プログラム・抄録集　11回　179-179　2025年8月

    出版者・発行元： (一社)日本筋学会

    ISSN： 2433-975X

  4. 放射線誘発粘膜炎による嚥下機能低下に対するキシロカイン口腔内投与の効果

    久岡巧麻, 鈴木淳, 池田怜吉, 太田淳, 平野愛, 香取幸夫

    日本嚥下医学会抄録(Web)　48th　2025年

  5. 誤嚥防止手術が慢性誤嚥による気管軟化症の改善に寄与したと考えられた一例

    太田淳, 平野愛, 香取幸夫

    日本喉頭科学会総会学術講演会プログラムおよび予稿集　36th　2024年

  6. 誤嚥防止手術-喉頭中央部切除術を中心に-

    平野愛, 太田淳, 加藤健吾, 香取幸夫

    日本耳鼻咽喉科頭頚部外科学会会報　127　(4)　2024年

    ISSN： 2436-5793

  7. 嚥下治療センター受診患者の不安と嚥下機能の関係

    久岡巧麻, 鈴木淳, 太田淳, 平野愛, 香取幸夫

    日本嚥下医学会抄録(Web)　47th　2024年

  8. 当院嚥下センターを受診した封入体筋炎の症例

    久岡巧麻, 平野愛, 太田淳, 香取幸夫

    日本嚥下医学会抄録(Web)　46th　2023年

  9. 嚥下障害の手術を極める!プロに学ぶコツとトラブルシューティング《誤嚥防止手術》喉頭中央部切除術

    平野愛, 太田淳

    耳鼻咽喉科・頭頚部外科　95　(12)　2023年

    ISSN： 0914-3491

  10. 舌圧と兵頭スコアを用いて嚥下障害の多職種間情報共有を行った抗NXP-2抗体陽性皮膚筋炎の一例

    太田淳, 平野愛, 久岡巧麻, 森山さや香, 香取幸夫

    日本摂食嚥下リハビリテーション学会学術大会抄録集(Web)　29th　2023年

  11. 甲状腺癌術後の重度嚥下障害に対し,多職種連携により経口摂取可能となった一例

    久岡巧麻, 平野愛, 太田淳, 香取幸夫

    日本摂食嚥下リハビリテーション学会学術大会抄録集(Web)　29th　2023年

  12. 耳鼻咽喉・頭頸部外科病棟における管理栄養士病棟配置の効果

    玉山咲紀, 石井亮, 布田美貴子, 平野愛, 太田淳, 香取幸夫, 香取幸夫

    日本摂食嚥下リハビリテーション学会学術大会抄録集(Web)　29th　2023年

  13. 【窒息ゼロを目指す】実践報告 東北大学病院(宮城県仙台市青葉区)誤嚥・窒息予防のための多職種・多部門の連携

    田畑 雅央, 平野 愛, 太田 淳, 白石 成, 土肥 千秋, 香取 幸夫

    患者安全推進ジャーナル　(70)　18-23　2022年12月

    出版者・発行元： (公財)日本医療機能評価機構

  14. 3D-VR画像による評価と経鼻中隔アプローチによる鼻内視鏡下摘出術が有用であった上咽頭異物の1例

    中山勇樹, 鈴木淳, 太田淳, 平野愛, 高橋ひより, 中角美穂, 大越明, 香取幸夫

    日本耳鼻咽喉科頭頚部外科学会会報　125　(4)　2022年

    ISSN： 2436-5793

  15. 多系統萎縮症における患者背景,嚥下スクリーニング検査の結果と嚥下障害の重症度に関する検討

    平野愛, 平野愛, 太田淳, 香取幸夫

    日本喉頭科学会総会学術講演会プログラムおよび予稿集　34th　2022年

  16. 舌癌術後の摂食・嚥下障害に対する歯科補綴学的介入の効果-手術内容別の考察-

    泉田一賢, 泉田一賢, 小山重人, 小山重人, 佐藤奈央子, 佐藤奈央子, 水戸武彦, 水戸武彦, 平野愛, 加藤健吾, 香取幸夫, 佐々木啓一

    日本嚥下医学会抄録(Web)　42nd　2019年

  17. 嚥下内視鏡検査における筋強直性ジストロフィー患者の嚥下障害の特徴と嚥下スクリーニング検査等の有効性の検討

    大村 悠, 平野 愛, 小林 祐太, 日指 志乃布, 由利 博美, 谷口 さやか, 高橋 俊明

    筋ジストロフィー医療研究　4　72-72　2017年10月

    出版者・発行元： 筋ジストロフィー医療研究会

    ISSN： 2433-1708

  18. Duchenne型筋ジストロフィー患者の嚥下機能評価

    平野愛, 小林祐太, 太田淳, 平野愛, 小林祐太, 太田淳, 大村悠, 由利博美, 武田篤, 香取幸夫

    日本摂食嚥下リハビリテーション学会学術大会抄録集(Web)　23rd　2017年

  19. 東北大学病院における医科歯科合同の摂食嚥下治療センター開設の取り組み

    鹿島 和孝, 加藤 健吾, 平野 愛, 太田 淳, 石井 亮, 渡邊 健一, 佐藤 剛史, 石河 理紗, 松井 裕之, 佐藤 奈央子, 松舘 芳樹, 古澤 義人, 伊藤 恵美, 細川 亮一, 小山 重人, 香取 幸夫, 上月 正博, 出江 紳一

    嚥下医学　5　(2)　299-299　2016年9月

    出版者・発行元： 日本嚥下医学会

    ISSN： 2186-3199

  20. Three cases of tuberculosis in the neck

    Ai Kawamoto, Masaki Ogura, Yukio Katori

    Practica Oto-Rhino-Laryngologica　106　(3)　273-277　2013年

    DOI： 10.5631/jibirin.106.273 　

    ISSN： 0032-6313

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共同研究・競争的資金等の研究課題 3

  1. ヒト嚥下筋の組織学的検討―多施設共同研究によるサルコペニアの嚥下障害の病態解明

    巨島 文子, 久保田 暁, 清水 潤, 藤本 保志, 杉山 庸一郎, 國枝 顕二郎, 平野 愛, 森 健一

    2023年4月1日 ～ 2026年3月31日

  2. 転写因子Nrf2の細胞保護・抗炎症作用に着目した、嚥下障害新規治療法の研究

    香取 幸夫, 井上 誠, 本藏 陽平, 池田 怜吉, 岡崎 達馬, 杉山 庸一郎, 白石 成, 平野 愛, 鈴木 淳

    提供機関：Japan Society for the Promotion of Science

    制度名：Grants-in-Aid for Scientific Research

    研究種目：Grant-in-Aid for Scientific Research (B)

    研究機関：Tohoku University

    2022年4月1日 ～ 2025年3月31日

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    小動物用嚥下透視装置の記録において前年度にフレームロスの問題が生じていたが、記録用ソフトウエアの臨床現場で用いているものに変更して適切にセッティングを進めたことで、1秒あたり30フレームでコマ落ちのない正確な記録を可能とした。この嚥下造影システムでC57BL6系列のマウスを用い、若年正常マウスにおける嚥下口腔期機能の指標（顎開閉距離、挺舌回数/嚥下回数）および嚥下咽頭期機能の指標（咽頭通過時間、食塊面積）について標準値を求めた。同系列の①亜鉛欠損食を与えたマウス、②酸化ストレスに脆弱性のある転写因子Nrfの遺伝子改変マウス、③アルコール接収（腹腔内投与）を負荷したマウス、ならびに④加齢モデルマウスについて嚥下造影検査を指向した。①、②、③のマウス群では 嚥下口腔期機能の低下を示唆する結果が得られた。一方で嚥下咽頭期の機能には正常例と比べて有意な差は現れていない。④については動物の長期飼育・実験中である。 鼻腔からリポポリサッカライドを投与する誤嚥モデルマウスを作成し、酸化ストレスに脆弱性のある転写因子Nrfをノックアウトした遺伝子改変マウスと野生型を用いて、体重増減ならびに嚥下関連筋（舌筋、顎二腹筋）、横隔膜、肺組織の評価を行った。Nrfをノックアウトしたマウスは体重の減少が著しく、組織では肺炎がより重度で、嚥下筋群や横隔膜の萎縮の程度が大きく、誤嚥性肺炎の重症度と嚥下関連筋の萎縮が相関することが示唆された。 人の嚥下機能の評価に、新たに超音波Bモード画像のスペクトルトラッキングによる嚥下運動解析法を検討し、体表から低侵襲で行える検査として有望であることを示した。 人において、酸化ストレスに脆弱性のある一塩基多型が嚥下機能の低下や誤嚥性肺炎の発症頻度や重症洞に関係するかどうかを検討する観察研究を多施設で進めるために研究計画の立案と研究倫理審査申請を進めた。

  3. 転写因子Nrf2の細胞保護・抗炎症作用に着目した、嚥下障害新規治療法の研究

    香取 幸夫, 井上 誠, 杉山 庸一郎, 鈴木 淳, 岡崎 達馬, 本藏 陽平, 白石 成, 平野 愛, 池田 怜吉

    提供機関：Japan Society for the Promotion of Science

    制度名：Grants-in-Aid for Scientific Research

    研究種目：Grant-in-Aid for Scientific Research (B)

    研究機関：Tohoku University

    2022年4月1日 ～ 2025年3月31日