研究者詳細

顔写真

ナカセ　タイゼン
中瀬　泰然
Taizen Nakase
所属
加齢医学研究所　脳科学研究部門　臨床加齢医学研究分野
職名
准教授
学位

  • 医学博士 （京都府立医科大学）

e-Rad 研究者番号
60390928

学歴 4

  • ブリティッシュコロンビア大学　医学部　ライフサイエンス研究所

    2002年9月 ～ 2003年12月

  • ウエスタンオンタリオ大学　医学部

    2001年3月 ～ 2002年8月

  • 京都府立医科大学大学院　医学研究科　病態病理学

  • 京都府立医科大学　医学部

所属学協会 6

  • 日本老年医学会

  • 日本認知症学会

  • 日本内科学会

  • 日本神経病理学会

  • 日本脳卒中学会

  • 日本神経学会

︎全件表示 ︎最初の5件までを表示

研究キーワード 5

  • 認知症

  • 脳卒中

  • 神経病理学

  • 病態病理

  • Pathology and applied neurobiology

研究分野 2

  • ライフサイエンス / 神経内科学 / 脳血管障害

  • ライフサイエンス / 認知脳科学 / 認知症

受賞 1

  1. 日本神経病理学会賞

    2018年9月　日本神経病理学会

論文 98

  1. Circuit training intervention for cognitive function, gut microbiota, and aging control: study protocol for a longitudinal, open-label randomized controlled trial

    Keishi Soga, Michio Takahashi, Akari Uno, Takamitsu Sinada, Kentaro Oba, Keisei Kawashima, Yasuko Tatewaki, Taizen Nakase, Yasuyuki Taki

    Trials　26　(1)　2025年3月18日

    出版者・発行元： Springer Science and Business Media LLC

    DOI： 10.1186/s13063-025-08807-9 　

    eISSN：1745-6215

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    Abstract Background Long-term exercise is increasingly considered an effective strategy to counteract cognitive decline associated with aging. Previous studies have indicated that circuit training exercises integrating aerobic and resistance modalities positively affect cognitive function. Furthermore, a growing body of evidence suggests that long-term exercise alters the gut microbiota, leading to an optimal environment for cognitive enhancement. Recent empirical evidence suggests that exercise plays a significant role in modulating aging-control factors at the protein level. Although the interaction between exercise and cognitive function is multifaceted, most studies have only examined a direct pathway from exercise to cognitive function. Therefore, this study aims to elucidate the effects of long-term circuit training on cognitive function through a comprehensive analysis of factors such as gut microbiota and proteins related to aging control. Methods A total of fifty-one participants will be randomly assigned to either the circuit training or waitlist control group. The intervention group will participate in a circuit training program developed by Curves Japan Co., Ltd. two to three times weekly for 16 weeks. The control group will continue their usual daily routines without participating in any new active lifestyle program. The participants will undergo cognitive assessments at baseline and after the intervention. Fecal and blood samples for protein analysis will be collected before and after the intervention. The effect of exercise on cognition will be analyzed by comparing the measured outcomes before and after the intervention. The associations among these outcomes will be assessed using a linear mixed model and structural equation modeling approaches. Discussion This study aims to provide the first insights into the comprehensive effects of exercise on cognitive function from the perspectives of gut microbiota and aging control. The findings are expected to contribute to improving brain health and combating age-related cognitive decline. Furthermore, the findings may help establish new guidelines for future studies on the relationship between exercise and cognitive function.

  2. Blood Biomarkers Reflect Dementia Symptoms and Are Influenced by Cerebrovascular Lesions. 国際誌

    Taizen Nakase, Yasuko Tatewaki, Yumi Takano, Shuko Nomura, Hae Woon Baek, Yasuyuki Taki

    International journal of molecular sciences　26　(5)　2025年3月5日

    DOI： 10.3390/ijms26052325 　

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    Dementia blood biomarkers are becoming increasingly important. Various factors, such as ischemic lesions and inflammation, can influence the pathomechanism of dementia. We aimed to evaluate the effects of past stroke lesions on blood biomarkers (BMs). Following approval from the institutional ethics committee, patients who were admitted to the memory clinic and were consented to written documents were enrolled (n = 111, average [standard deviation] age: 74.5 [9.1] years-old). Brain magnetic resonance imaging, cognitive function, and neuropsychological symptoms were analyzed. The amyloid-β 42 (Aβ42)/Aβ40 ratio, phosphorylated tau181 (p-tau181), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and Aβ42/p-tau181 ratio were assessed as plasma BMs. The patients were diagnosed with Alzheimer's disease (n = 45), mild cognitive impairment (n = 56), depression (n = 8), and subjective cognitive impairment (n = 4). Bivariate analysis exhibited that all measured BM indicators were significantly associated with cognitive decline in patients without past stroke lesions. Whereas the patients with stroke lesions presented a significant association only between GFAP and cognitive decline (p = 0.0011). Multiple regression analysis showed that NfL significantly correlated with cognitive decline only in patients without stroke lesions (r = 0.4988, p = 0.0003) and with delusion only in those with stroke lesions (r = 0.5492, p = 0.0121). Past stroke lesions should be addressed in the assessment of the correlation between blood biomarkers and cognitive decline in dementia patients.

  3. 自記式問診票を通じた聴覚の自己評価とオージオグラムの比較検討

    冨田 尚希, 加藤 大雅, 佐藤 剛史, 内林 俊洋, 本蔵 陽平, 鈴木 淳, 中瀬 泰然, 瀧 靖之, 香取 幸夫

    日本老年医学会雑誌　61　(Suppl.)　181-181　2024年5月

    出版者・発行元： (一社)日本老年医学会

    ISSN：0300-9173

  4. Association between Gray and White Matter Lesions and Its Involvement in Clinical Symptoms of Alzheimer's-Type Dementia. 国際誌

    Taizen Nakase, Benjamin Thyreau, Yasuko Tatewaki, Naoki Tomita, Yumi Takano, Michiho Muranaka, Yasuyuki Taki

    Journal of clinical medicine　12　(24)　2023年12月12日

    DOI： 10.3390/jcm12247642 　

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    BACKGROUND: Not only gray matter lesions (GMLs) but also white matter lesions (WMLs) can play important roles in the pathology of Alzheimer's disease (AD). The progression of cognitive impairment (CI) and behavioral and psychological symptoms of dementia (BPSD) might be caused by a concerted effect of both GML and WML. OBJECTIVE: This study aimed to investigate the association between GML and WML and how they are involved in the symptoms of CI and BPSD in dementia patients by means of imaging technology. METHODS: Patients in our memory clinic, who were diagnosed with AD-type dementia or amnestic mild cognitive impairment (aMCI) and had undergone both single-photon emission computed tomography (SPECT) and brain MRI, were consecutively enrolled (n = 156; 61 males and 95 females; 79.8 ± 7.4 years old). Symptoms of CI and BPSD were obtained from patients' medical records. For the analysis of GMLs and WMLs, SPECT data and MRI T1-weighted images were used, respectively. This study followed the Declaration of Helsinki, and all procedures were approved by the institutional ethics committee. RESULTS: According to a multivariate analysis, disorientation and disturbed attention demonstrated a relationship between the precuneus and WMLs in both hemispheres. Hyperactivity in BPSD showed multiple correlations between GMLs on both sides of the frontal cortex and WMLs. Patients with aMCI presented more multiple correlations between GMLs and WMLs compared with those with AD-type dementia regarding dementia symptoms including BPSD. CONCLUSION: The interaction between GMLs and WMLs may vary depending on the symptoms of CI and BPSD. Hyperactivity in BPSD may be affected by the functional relationship between GMLs and WMLs in the left and right hemispheres. The correlation between GMLs and WMLs may be changing in AD-type dementia and aMCI.

  5. 白質病変の定量化による日本人大規模高齢者集団の食事パターンと認知症に関する研究

    陳 俐穎, 舘脇 康子, Thyreau Benjamin, 内田 和宏, 壹岐 ひかり, 中瀬 泰然, 中路 重之, 前田 哲也, 野口 もえ子[篠原], 三村 將, 中島 健二, 伊賀 淳一, 竹林 実, 二宮 利治, 瀧 靖之

    Dementia Japan　37　(4)　666-666　2023年10月

    出版者・発行元： (一社)日本認知症学会

    ISSN：1342-646X

  6. 臨床的アルツハイマー病疑い患者におけるアミロイドPETとSPECT・MMSEの関連性の検討

    山崎 真瞳子, 舘脇 康子, 中瀬 泰然, 村中 美千帆, 高野 由美, 冨田 尚希, 児玉 裕康, 瀧 靖之

    Dementia Japan　37　(4)　657-657　2023年10月

    出版者・発行元： (一社)日本認知症学会

    ISSN：1342-646X

  7. ポリファーマシーに関連した問題点の適正化が主要な診療となった5症例の検討

    冨田 尚希, 村中 美千帆, 舘脇 康子, 高野 由美, 山本 修三, 中瀬 泰然, 瀧 靖之

    日本老年医学会雑誌　60　(4)　457-457　2023年10月

    出版者・発行元： (一社)日本老年医学会

    ISSN：0300-9173

  8. アルツハイマー型認知症の臨床症状における大脳皮質および白質病変の関与についての検討

    中瀬 泰然, 舘脇 康子, 冨田 尚希, 村中 美千帆, 高野 由美, 山本 修三, 瀧 靖之

    日本内科学会雑誌　112　(臨増)　160-160　2023年2月

    出版者・発行元： (一社)日本内科学会

    ISSN：0021-5384

    eISSN：1883-2083

  9. Impact of atrial fibrillation on the cognitive decline in Alzheimer's disease. 国際誌 査読有り

    Taizen Nakase, Yasuko Tatewaki, Benjamin Thyreau, Hayato Odagiri, Naoki Tomita, Shuzo Yamamoto, Yumi Takano, Michiho Muranaka, Yasuyuki Taki

    Alzheimer's research & therapy　15　(1)　15-15　2023年1月13日

    DOI： 10.1186/s13195-023-01165-1 　

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    BACKGROUND: Atrial fibrillation (AF) is a strong risk factor for Alzheimer's disease (AD) independent of ischemic stroke. However, the clinicopathological impact of AF on the severity of AD has not been well elucidated. We aimed to investigate the clinical differences between dementia patients with AF and those without AF by means of imaging data. METHODS: Following approval from the institutional ethics committee, patients with newly diagnosed AD or amnestic mild cognitive impairment (aMCI) were retrospectively screened (n = 170, 79.5 ± 7.4 years old). Cognitive function was assessed using the Mini-Mental State Examination (MMSE). Based on the MRI data, the cerebral volume, cerebral microbleeds (CMBs), periventricular white matter lesions (WMLs), and deep WMLs were evaluated. The regional cerebral blood flow (rCBF) was measured using 123I-IMP SPECT. RESULTS: Of the patients, 14 (8.2%) and 156 (91.8%) had AF (AF group) and sinus rhythm (SR group), respectively. The AF group had significantly lower MMSE scores than the SR group (average [standard deviation (SD)]: 19.4 [4.4] and 22.0 [4.4], respectively; p = 0.0347). Cerebral volume and CMBs did not differ between the two groups. The periventricular WMLs, but not the deep WMLs, were significantly larger in the AF group than in the SR group (mean [SD] mL: 6.85 [3.78] and 4.37 [3.21], respectively; p = 0.0070). However, there was no significant difference in rCBF in the areas related to AD pathology between the two groups. CONCLUSION: AD and aMCI patients with AF showed worse cognitive decline along with larger periventricular WMLs compared to those with SR, although the reduction of rCBF was not different between patients with AF and SR. The white matter lesions may be a more important pathology than the impairment of cerebral blood flow in dementia patients with AF. A larger study is needed to confirm our findings in the future.

  10. Impact of hs-CRP concentration on brain structure alterations and cognitive trajectory in Alzheimer's disease. 国際誌

    Ye Zhang, Yasuko Tatewaki, Taizen Nakase, Yingxu Liu, Naoki Tomita, Benjamin Thyreau, Haixia Zheng, Michiho Muranaka, Yumi Takano, Tatsuo Nagasaka, Yasuyuki Taki

    Frontiers in aging neuroscience　15　1227325-1227325　2023年

    DOI： 10.3389/fnagi.2023.1227325 　

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    INTRODUCTION: Present study was to investigate hs-CRP concentration, brain structural alterations, and cognitive function in the context of AD [Subjective cognitive decline (SCD), mild cognitive impairment (MCI), and AD]. METHODS: We retrospectively included 313 patients (Mean age = 76.40 years, 59 SCD, 101 MCI, 153 AD) in a cross-sectional analysis and 91 patients (Mean age = 75.83 years, 12 SCD, 43 MCI, 36 AD) in a longitudinal analysis. Multivariable linear regression was conducted to investigate the relationship between hs-CRP concentration and brain structural alterations, and cognitive function, respectively. RESULTS: Hs-CRP was positively associated with gray matter volume in the left fusiform (β = 0.16, pFDR = 0.023) and the left parahippocampal gyrus (β = 0.16, pFDR = 0.029). Post hoc analysis revealed that these associations were mainly driven by patients with MCI and AD. The interaction of diagnosis and CRP was significantly associated with annual cognitive changes (β = 0.43, p = 0.008). Among these patients with AD, lower baseline CRP was correlated with greater future cognitive decline (r = -0.41, p = 0.013). CONCLUSION: Our study suggests that increased hs-CRP level may exert protective effect on brain structure alterations and future cognitive changes among patients already with cognitive impairment.

  11. Efficacy of a mixture of Ginkgo biloba, sesame, and turmeric on cognitive function in healthy adults: Study protocol for a randomized, double-blind, placebo-controlled trial. 国際誌 査読有り

    Taizen Nakase, Yasuko Tatewaki, Izumi Matsudaira, Kouki Kobayashi, Hikari Iki, Haruka Asaoka, Radiztia Ekayantri, Michiho Muranaka, Hiroyuki Murata, Tatsushi Mutoh, Yasuyuki Taki

    PloS one　18　(3)　e0280549　2023年

    DOI： 10.1371/journal.pone.0280549 　

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    BACKGROUND AND PURPOSE: Ginkgo biloba extract (GBE) reportedly ameliorates cognitive function in patients with chronic cerebrovascular insufficiency. However, its efficacy in healthy adults is ambiguous. It was reported that concentrations of terpene lactones, active components of GBE that are present in very low concentrations in the brain, were significantly increased following administration of a mixture of GBE, sesame seed, and turmeric (GBE/MST) in mice. This study aims to investigate the effectiveness of GBE/MST on the cognitive function of healthy adults by comparing it with that of GBE alone. METHODS: Altogether, 159 participants providing informed consent will be recruited from a population of healthy adults aged 20-64 years. Normal cognitive function at baseline will be confirmed using the Japanese version of the Montreal Cognitive Assessment battery. Participants will be randomly assigned in a double-blind manner to the GBE/MST, GBE, and placebo groups in a 1:1:1 ratio. The Wechsler Memory Scale, Trail Making Test, and Stroop Color and Word Test will be used to assess the memory and executive functions at baseline and at the endpoint (24 weeks). For biological assessment, resting state functional magnetic resonance imaging (rs-fMRI) will be performed simultaneously with the neuropsychological tests. DISCUSSION: This study aims to obtain data that can help compare the profile changes in memory and executive functions among participants consuming GBE/MST, GBE alone, and placebo for 24 weeks. Alterations in the default mode network will be evaluated by comparing the rs-fMRI findings between baseline and 24 weeks in the aforementioned groups. Our results may clarify the impact of GBE on cognitive function and the functional mechanism behind altered cognitive function induced by GBE components. TRIAL REGISTRATION: This study was registered in the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR; registration number: UMIN000043494). This information can be searched on the website of the International Clinical Trials Registry Platform Search Portal of the World Health Organization under the Japan Primary Registries Network.

  12. Impact of constipation on progression of Alzheimer's disease: A retrospective study. 国際誌 査読有り

    Taizen Nakase, Yasuko Tatewaki, Benjamin Thyreau, Tatsushi Mutoh, Naoki Tomita, Shuzo Yamamoto, Yumi Takano, Michiho Muranaka, Yasuyuki Taki

    CNS neuroscience & therapeutics　28　(12)　1964-1973　2022年12月

    DOI： 10.1111/cns.13940 　

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    BACKGROUND AND PURPOSE: In terms of the gut-brain axis, constipation has been considered to be an important factor of neurodegenerative diseases, although the exact mechanism is still controversial. Herein, we aimed to investigate the contribution of constipation to the progression of dementia in a retrospective study. METHODS: Patients of Alzheimer's disease(AD) and amnestic mild cognitive impairment were consecutively screened between January 2015 and December 2020, and those of whom brain MRI and neuropsychological tests were performed twice were enrolled in this study. Participants were classified into with constipation (Cons[+], n = 20) and without constipation (Cons[-], n = 64) groups. Laboratory data at the first visit were used. Regression analysis was performed in MMSE, ADAS-Cog, and the volumes of hippocampus on MRI-MPRAGE images and deep white matter lesions (DWMLs) on MRI-FLAIR images obtained at two different time points. RESULTS: The main finding was that the Cons[+] group showed 2.7 times faster decline in cognitive impairment compared with the Cons[-] group, that is, the liner coefficients of ADAS-Cog were 2.3544 points/year in the Cons[+] and 0.8592 points/year in the Cons[-] groups. Ancillary, changes of DWMLs showed significant correlation with the time span (p < 0.01), and the liner coefficients of DWMLs were 24.48 ml/year in the Cons[+] and 14.83 ml/year in the Cons[-] group, although annual rate of hippocampal atrophy was not different between the two groups. Moreover, serum homocysteine level at baseline was significantly higher in the Cons[+] group than Cons[-] group (14.6 ± 6.4 and 11.5 ± 4.2 nmol/ml, respectively: p = 0.03). CONCLUSION: There is a significant correlation between constipation and faster progression of AD symptoms along with expansion of DWMLs.

  13. MRI画像を用いて測定した咬筋断面積と物忘れ患者の認知機能の相関に関する検討

    村中 美千帆, 舘脇 康子, Benjamin Thyreau, 阪本 真弥, 高野 由美, 山本 修三, 冨田 尚希, 中瀬 泰然, 瀧 靖之

    老年精神医学雑誌　33　(増刊II)　265-265　2022年11月

    出版者・発行元： (株)ワールドプランニング

    ISSN：0915-6305

  14. アルツハイマー型認知症周辺症状に対する各種治療薬の効果についての検討

    中瀬 泰然, 冨田 尚希, 舘脇 康子, 高野 由美, 村中 美千帆, 山本 修三, 瀧 靖之

    老年精神医学雑誌　33　(増刊II)　288-288　2022年11月

    出版者・発行元： (株)ワールドプランニング

    ISSN：0915-6305

  15. MRI画像を用いて測定した咬筋断面積と物忘れ患者の認知機能の相関に関する検討

    村中 美千帆, 舘脇 慶子, Benjamin Thyreau, 阪本 真弥, 高野 由美, 山本 修三, 冨田 尚希, 中瀬 泰然, 瀧 靖之

    Dementia Japan　36　(4)　761-761　2022年10月

    出版者・発行元： (一社)日本認知症学会

    ISSN：1342-646X

  16. アルツハイマー型認知症周辺症状に対する各種治療薬の効果についての検討

    中瀬 泰然, 冨田 尚希, 舘脇 康子, 高野 由美, 村中 美千帆, 山本 修三, 瀧 靖之

    Dementia Japan　36　(4)　771-771　2022年10月

    出版者・発行元： (一社)日本認知症学会

    ISSN：1342-646X

  17. Impact of Catheter Ablation on Brain Microstructure and Blood Flow Alterations for Cognitive Improvements in Patients with Atrial Fibrillation: A Pilot Longitudinal Study. 国際誌 査読有り

    Yasuko Tatewaki, Tatsushi Mutoh, Hirokazu Sato, Akiko Kobayashi, Tomoko Totsune, Benjamin Thyreau, Atsushi Sekiguchi, Taizen Nakase, Tetsuo Yagi, Yasuyuki Taki

    Journal of clinical medicine　11　(15)　2022年7月26日

    DOI： 10.3390/jcm11154346 　

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    Atrial fibrillation (AF) predisposes patients to develop cognitive decline and dementia. Clinical and epidemiological data propose that catheter ablation may provide further benefit to improve neurocognitive function in patients with AF, but the underlying mechanism is poorly available. Here, we conducted a pilot prospective study to investigate whether AF ablation can alter regional cerebral blood flow (rCBF) and brain microstructures, using multimodal magnetic resonance imaging (MRI) technique. Eight patients (63 ± 7 years) with persistent AF underwent arterial-spin labeling (ASL) perfusion, 3D T1-structural images and cognitive test batteries before and 6 months after intervention. ASL and structural MR images were spatially normalized, and the rCBF and cortical thickness of different brain areas were compared between pre- and 6-month post-treatment. Cognitive-psychological function was improved, and rCBF was significantly increased in the left posterior cingulate cortex (PCC) (p = 0.013), whereas decreased cortical thickness was found in the left posterior insular cortex (p = 0.023). Given that the PCC is a strategic site in the limbic system, while the insular cortex is known to play an important part in the central autonomic nervous system, our findings extend the hypothesis that autonomic system alterations are an important mechanism explaining the positive effect of AF ablation on cognitive function.

  18. Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer's disease. 国際誌 査読有り

    Ye Zhang, Yasuko Tatewaki, Yingxu Liu, Naoki Tomita, Tatsuo Nagasaka, Michiho Muranaka, Shuzo Yamamoto, Yumi Takano, Taizen Nakase, Tatsushi Mutoh, Yasuyuki Taki

    GeroScience　44　(3)　1563-1574　2022年6月

    DOI： 10.1007/s11357-022-00584-6 　

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    Both objective and perceived social isolations were associated with future cognitive decline and increase risk of Alzheimer's disease (AD). However, the impacts of perceived social isolation depending on different clinical stages of AD have not been elucidated. The aim of this study was to investigate the influence of perceived social isolation or loneliness on brain structure and future cognitive trajectories in patients who are living with or are at risk for AD. A total of 176 elderly patients (mean age of 78 years) who had complaint of memory problems (39 subjective cognitive decline [SCD], 53 mild cognitive impairment [MCI], 84 AD) underwent structural MRI and neuropsychological testing. Loneliness was measured by one binary item question "Do you often feel lonely?." Voxel-based morphometry was conducted to evaluate regional gray matter volume (rGMV) difference associated with loneliness in each group. To evaluate individual differences in cognitive trajectories based on loneliness, subgroup analysis was performed in 51 patients with AD (n = 23) and pre-dementia status (SCD-MCI, n = 28) using the longitudinal scores of Alzheimer's Disease Assessment Scale-cognitive component-Japanese version (ADAS-Jcog). Whole brain VBM analysis comparing lonely to non-lonely patients revealed loneliness was associated with decreased rGMV in bilateral thalamus in SCD patients and in the left middle occipital gyrus and the cerebellar vermal lobules I - V in MCI patients. Annual change of ADAS-Jcog in patients who reported loneliness was significantly greater comparing to these non-lonely in SCD-MCI group, but not in AD group. Our results indicate that perceived social isolation, or loneliness, might be a comorbid symptom of patients with SCD or MCI, which makes them more vulnerable to the neuropathology of future AD progression.

  19. アルツハイマー型認知症の進行に影響する心房細動についての検討

    中瀬 泰然, 舘脇 康子, Thyreau Benjamin, 武藤 達士, 冨田 尚希, 山本 修三, 高野 由美, 村中 美千帆, 瀧 靖之

    日本老年医学会雑誌　59　(Suppl.)　104-104　2022年5月

    出版者・発行元： (一社)日本老年医学会

    ISSN：0300-9173

  20. Alzheimer's Disease and Type 2 Diabetes Mellitus: The Use of MCT Oil and a Ketogenic Diet. 国際誌 査読有り

    Junpei Takeishi, Yasuko Tatewaki, Taizen Nakase, Yumi Takano, Naoki Tomita, Shuzo Yamamoto, Tatsushi Mutoh, Yasuyuki Taki

    International journal of molecular sciences　22　(22)　2021年11月15日

    DOI： 10.3390/ijms222212310 　

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    Recently, type 2 diabetes mellitus (T2DM) has been reported to be strongly associated with Alzheimer's disease (AD). This is partly due to insulin resistance in the brain. Insulin signaling and the number of insulin receptors may decline in the brain of T2DM patients, resulting in impaired synaptic formation, neuronal plasticity, and mitochondrial metabolism. In AD patients, hypometabolism of glucose in the brain is observed before the onset of symptoms. Amyloid-β accumulation, a main pathology of AD, also relates to impaired insulin action and glucose metabolism, although ketone metabolism is not affected. Therefore, the shift from glucose metabolism to ketone metabolism may be a reasonable pathway for neuronal protection. To promote ketone metabolism, medium-chain triglyceride (MCT) oil and a ketogenic diet could be introduced as an alternative source of energy in the brain of AD patients.

  21. アルツハイマー病の進行に関与する便秘の影響についての検討

    中瀬 泰然, 舘脇 康子, Thyreau Benjamin, 武藤 達士, 冨田 尚希, 山本 修三, 高野 由美, 村中 美千帆, 瀧 靖之

    Dementia Japan　35　(4)　614-614　2021年10月

    出版者・発行元： (一社)日本認知症学会

    ISSN：1342-646X

  22. 認知症病態に関わる心房細動の影響についての検討

    中瀬 泰然, 竹石 潤平, 舘脇 康子, Benjamin Thyreau, 武藤 達士, 冨田 尚希, 山本 修三, 高野 由美, 村中 美千帆, 瀧 靖之

    Dementia Japan　35　(4)　620-620　2021年10月

    出版者・発行元： (一社)日本認知症学会

    ISSN：1342-646X

  23. Cerebral microbleeds development after stroke thrombolysis: A secondary analysis of the THAWS randomized clinical trial. 国際誌 査読有り

    Kaori Miwa, Masatoshi Koga, Manabu Inoue, Sohei Yoshimura, Makoto Sasaki, Yusuke Yakushiji, Mayumi Fukuda-Doi, Yasushi Okada, Taizen Nakase, Masafumi Ihara, Yoshinari Nagakane, Shunya Takizawa, Koko Asakura, Junya Aoki, Kazumi Kimura, Haruko Yamamoto, Kazunori Toyoda

    International journal of stroke : official journal of the International Stroke Society　17　(6)　17474930211035023-17474930211035023　2021年8月3日

    DOI： 10.1177/17474930211035023 　

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    BACKGROUND AND AIM: We determined to investigate the incidence and clinical impact of new cerebral microbleeds after intravenous thrombolysis in patients with acute stroke. METHODS: The THAWS was a multicenter, randomized trial to study the efficacy and safety of intravenous thrombolysis with alteplase in patients with wake-up stroke or unknown onset stroke. Prescheduled T2*-weighted imaging assessed cerebral microbleeds at three time points: baseline, 22-36 h, and 7-14 days. Outcomes included new cerebral microbleeds development, modified Rankin Scale (mRS) ≥3 at 90 days, and change in the National Institutes of Health Stroke Scale (NIHSS) score from 24 h to 7 days. RESULTS: Of all 131 patients randomized in the THAWS trial, 113 patients (mean 74.3 ± 12.6 years, 50 female, 62 allocated to intravenous thrombolysis) were available for analysis. Overall, 46 (41%) had baseline cerebral microbleeds (15 strictly lobar cerebral microbleeds, 14 mixed cerebral microbleeds, and 17 deep cerebral microbleeds). New cerebral microbleeds only emerged in the intravenous thrombolysis group (seven patients, 11%) within a median of 28.3 h, and did not additionally increase within a median of 7.35 days. In adjusted models, number of cerebral microbleeds (relative risk (RR) 1.30, 95% confidence interval (CI): 1.17-1.44), mixed distribution (RR 19.2, 95% CI: 3.94-93.7), and cerebral microbleeds burden ≥5 (RR 44.9, 95% CI: 5.78-349.8) were associated with new cerebral microbleeds. New cerebral microbleeds were associated with an increase in NIHSS score (p = 0.023). Treatment with alteplase in patients with baseline ≥5 cerebral microbleeds resulted in a numerical shift toward worse outcomes on ordinal mRS (median [IQR]; 4 [3-4] vs. 0 [0-3]), compared with those with <5 cerebral microbleeds (common odds ratio 17.1, 95% CI: 0.76-382.8). The association of baseline ≥5 cerebral microbleeds with ordinal mRS score differed according to the treatment group (p interaction = 0.042). CONCLUSION: New cerebral microbleeds developed within 36 h in 11% of the patients after intravenous thrombolysis, and they were significantly associated with mixed-distribution and ≥5 cerebral microbleeds. New cerebral microbleeds development might impede neurological improvement. Furthermore, cerebral microbleeds burden might affect the effect of alteplase.

  24. Japanese and Non-Japanese Patients with Transient Ischemic Attack or Minor Stroke: A Five-Year Risk Analysis of Stroke and Vascular Events. 査読有り

    Shinichiro Uchiyama, Takao Hoshino, Hugo Charles, Kenji Kamiyama, Taizen Nakase, Kazuo Kitagawa, Kazuo Minematsu, Kenichi Todo, Yasushi Okada, Jyoji Nakagawara, Ken Nagata, Hiroshi Yamagami, Takenori Yamaguchi, Pierre Amarenco

    Journal of atherosclerosis and thrombosis　2020年9月17日

    DOI： 10.5551/jat.58552 　

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    AIMS: We have previously reported 5-year follow-up data on the TIAregistry.org, an international prospective cohort in patients with transient ischemic attack (TIA) or minor stroke. We conducted a Japanese subgroup analysis because outcomes and predictors might differ according to ethnicities and regions. In this study, we compared the baseline and 5-year follow-up data of Japanese and non-Japanese patients with TIA or minor stroke. METHODS: Patients with TIA or minor ischemic stroke within 7 days after the onset were classified into two groups based on ethnicity, Japanese (n=345) and non-Japanese (n=3502); further, 5-year event rates were compared between the two groups. We also determined predictors of 5-year stroke for both groups. RESULTS: Vascular death and death from any cause were identified to be less prevalent, unlike stroke and intracranial hemorrhage, which was determined to be more prevalent in Japanese than in non-Japanese patients. Five-year rate of stroke was significantly higher in Japanese patients. Cumulative stroke and major cardiovascular event rates did not decline but instead linearly increased from 1 to 5 years in both groups. Baseline risk factors for 5-year stroke were as follows: age, diabetes, history of stroke or TIA, and congestive heart failure in Japanese patients. Independent predictors of 5-year stroke were large artery atherosclerosis, congestive heart failure, diabetes, and age in Japanese patients. CONCLUSIONS: Recurrent stroke and intracranial hemorrhage were determined to be more prevalent at 5 years after TIA or minor stroke in Japanese patients than in non-Japanese patients. Strategies to mitigate the long-term risks of stroke, aside from adherence to current guidelines, should take Japanese-patient-specific residual risks into account.

  25. Thrombolysis With Alteplase at 0.6 mg/kg for Stroke With Unknown Time of Onset: A Randomized Controlled Trial. 国際誌 査読有り

    Masatoshi Koga, Haruko Yamamoto, Manabu Inoue, Koko Asakura, Junya Aoki, Toshimitsu Hamasaki, Takao Kanzawa, Rei Kondo, Masafumi Ohtaki, Ryo Itabashi, Kenji Kamiyama, Toru Iwama, Taizen Nakase, Yusuke Yakushiji, Shuichi Igarashi, Yoshinari Nagakane, Shunya Takizawa, Yasushi Okada, Ryosuke Doijiri, Akira Tsujino, Yasuhiro Ito, Hideyuki Ohnishi, Takeshi Inoue, Yasushi Takagi, Yasuhiro Hasegawa, Yoshiaki Shiokawa, Nobuyuki Sakai, Masato Osaki, Yoshikazu Uesaka, Shinichi Yoshimura, Takao Urabe, Toshihiro Ueda, Masafumi Ihara, Takanari Kitazono, Makoto Sasaki, Akira Oita, Sohei Yoshimura, Mayumi Fukuda-Doi, Kaori Miwa, Kazumi Kimura, Kazuo Minematsu, Kazunori Toyoda

    Stroke　51　(5)　1530-1538　2020年5月

    DOI： 10.1161/STROKEAHA.119.028127 　

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    Background and Purpose- We assessed whether lower-dose alteplase at 0.6 mg/kg is efficacious and safe for acute fluid-attenuated inversion recovery-negative stroke with unknown time of onset. Methods- This was an investigator-initiated, multicenter, randomized, open-label, blinded-end point trial. Patients met the standard indication criteria for intravenous thrombolysis other than a time last-known-well >4.5 hours (eg, wake-up stroke). Patients were randomly assigned (1:1) to receive alteplase at 0.6 mg/kg or standard medical treatment if magnetic resonance imaging showed acute ischemic lesion on diffusion-weighted imaging and no marked corresponding hyperintensity on fluid-attenuated inversion recovery. The primary outcome was a favorable outcome (90-day modified Rankin Scale score of 0-1). Results- Following the early stop and positive results of the WAKE-UP trial (Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke), this trial was prematurely terminated with 131 of the anticipated 300 patients (55 women; mean age, 74.4±12.2 years). Favorable outcome was comparable between the alteplase group (32/68, 47.1%) and the control group (28/58, 48.3%; relative risk [RR], 0.97 [95% CI, 0.68-1.41]; P=0.892). Symptomatic intracranial hemorrhage within 22 to 36 hours occurred in 1/71 and 0/60 (RR, infinity [95% CI, 0.06 to infinity]; P>0.999), respectively. Death at 90 days occurred in 2/71 and 2/60 (RR, 0.85 [95% CI, 0.06-12.58]; P>0.999), respectively. Conclusions- No difference in favorable outcome was seen between alteplase and control groups among patients with ischemic stroke with unknown time of onset. The safety of alteplase at 0.6 mg/kg was comparable to that of standard treatment. Early study termination precludes any definitive conclusions. Registration- URL: https://www.clinicaltrials.gov; Unique identifier: NCT02002325.

  26. Japanese Versus Non-Japanese Patients with Transient Ischemic Attack or Minor Stroke: Subanalysis of TIA registry.org. 国際誌 査読有り

    Shinichiro Uchiyama, Takao Hoshino, Leila Sissani, Monteiro Tavares Linsay, Kenji Kamiyama, Taizen Nakase, Kazuo Kitagawa, Kazuo Minematsu, Kenichi Todo, Yasushi Okada, Jyoji Nakagawara, Ken Nagata, Hiroshi Yamagami, Takenori Yamaguchi, Pierre Amarenco

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association　28　(8)　2232-2241　2019年8月

    DOI： 10.1016/j.jstrokecerebrovasdis.2019.05.005 　

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    BACKGROUND: TIAregistry.org is an international cohort of patients with transient ischemic attack (TIA) or minor stroke within 7 days before enrollment in the registry. Main analyses of 1-year follow-up data have been reported.5 We conducted subanalysis on the baseline and 1-year follow-up data of Japanese patients. METHODS: The patients were classified into 2 groups based on Japanese ethnicity, Japanese (345) and non-Japanese (3238), and their baseline data and 1-year event rates were compared. We also determined risk factors and predictors of 1-year stroke. RESULTS: Current smoking, regular alcohol drinking, intracranial arterial stenosis, and small vessel occlusion; and hypertension, dyslipidemia, coronary artery disease, and extracranial arterial stenosis were more and less common among Japanese patients, respectively. Stroke risk was higher and TIA risk was lower at 1-year follow-up among Japanese patients. The baseline risk factors for recurrent stroke were diabetes, alcohol drinking, and large artery atherosclerosis. Independent predictors of 1-year stroke risk were prior congestive heart failure and alcohol consumption. CONCLUSIONS: The two populations of patients featured differences in risk factors, stroke subtypes, and outcome events. Predictors of recurrent stroke among Japanese patients included congestive heart failure and regular alcohol drinking. Strategies to attenuate residual risk of stroke aside from adherence to current guidelines should take our Japanese-patient specific findings into account.

  27. Secular Trends in the Background of Intracerebral Hemorrhage from 2010 to 2015. 国際誌 査読有り

    Taizen Nakase, Junta Moroi, Tatsuya Ishikawa

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association　28　(1)　26-30　2019年1月

    DOI： 10.1016/j.jstrokecerebrovasdis.2018.09.010 　

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    OBJECTIVE: Direct oral anticoagulants (DOACs) were recently introduced for the clinical use in stroke prevention, and they are reported to show a lower risk of intracerebral hemorrhage (ICH) compared to warfarin. We were interested to know whether there is any change in clinical backgrounds of ICH patients to date. METHODS: From 2010 to 2015, ICH patients admitted to our hospital were consecutively screened (n = 658). Hematoma size was assessed by brain computed tomography images on admission. Outcome was measured by the modified Rankin Scale, and favorable outcome was defined as modified Rankin Scale 0-2. Biennial trends were compared in 3 periods, P1: 2010-2011, P2: 2012-2013, and P3: 2014-2015. RESULTS: The percentage of ICH patients taking antithrombotics had been slightly decreasing (P = .245: [P1] 33.0%, [P2] 27.4%, and [P3] 26.2%). The frequency of patients taking antiplatelets had significantly decreased (P = .001: [P1] 50.7%, [P2] 44.3%, and [P3] 22.8%), and those taking DOACs had significantly increased (P = .001: [P1] 1.4%, [P2] 4.9%, and [P3] 19.3%). Frequency of favorable outcomes in patients taking antithrombotics was slightly increased in P3 compared to P1 and P2 (23.3%, 21.1%, and 21.3%, respectively). There was no significant difference in hematoma size between patients taking warfarin and DOACs. CONCLUSIONS: Number of ICH patients taking antithrombotics has been slightly decreasing and the percentage taking DOACs among ICH has been increasing for 6 years.

  28. Outcome of Secondary Stroke Prevention in Patients Taking Non-Vitamin K Antagonist Oral Anticoagulants. 国際誌 査読有り

    Taizen Nakase, Junta Moroi, Tatsuya Ishikawa

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association　27　(5)　1174-1177　2018年5月

    DOI： 10.1016/j.jstrokecerebrovasdis.2017.11.032 　

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    BACKGROUND: Since non-vitamin K antagonist oral anticoagulants (NOACs) were released for clinical use, many studies have investigated its effectiveness in stroke prevention. In this study, to determine whether or not there is a difference in outcome in secondary stroke prevention between warfarin and NOACs, patients with embolic stroke with newly prescribed anticoagulants were prospectively analyzed. METHODS: Patients with acute ischemic stroke, who newly started anticoagulant therapy, were consecutively asked to participate in this study. Enrolled patients (76.3 ± 11.0 years old) were classified into warfarin (n = 48), dabigatran (n = 73), rivaroxaban (n = 49), and apixaban (n = 65). The outcome in 1 year was prospectively investigated at outpatient clinic or telephone interview. Recurrence of stroke and death was considered as the critical incidence. RESULTS: The prevalence of risk factors was not different among all medicines. Patients with dabigatran showed significantly younger onset age (P < .001: 72.2 years old) and milder neurologic deficits than patients on other medicines (P < .001). Cumulative incident rates were 7.1%, 15.3%, 19.0%, and 29.7% for dabigatran, apixaban, rivaroxaban, and warfarin, respectively. Dabigatran showed relatively better outcome compared with warfarin (P = .069) and rivaroxaban (P = .055). All patients on NOACs presented lower cumulative stroke recurrence compared with warfarin. CONCLUSION: Even in the situation of secondary stroke prevention, noninferiority of NOACs to warfarin might be demonstrated.

  29. Anti-inflammatory and antiplatelet effects of non-vitamin K antagonist oral anticoagulants in acute phase of ischemic stroke patients. 国際誌 査読有り

    Taizen Nakase, Junta Moroi, Tatsuya Ishikawa

    Clinical and translational medicine　7　(1)　2-2　2018年1月12日

    DOI： 10.1186/s40169-017-0179-9 　

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    BACKGROUND: Recently, non-vitamin K antagonist oral anticoagulants such as direct thrombin and direct factor Xa inhibitors have been prescribed for prevention of embolic stroke. While in Japan, argatroban, also a direct thrombin inhibitor, is available for the treatment of atherothrombotic stroke patients. This study aimed to explore whether there is any differences between direct thrombin and direct factor Xa inhibitors regarding the inhibiting effect against thrombogenesis in the clinical setting of acute ischemic stroke. METHODS: Acute ischemic stroke patients newly prescribed anti-thrombotic agents were consecutively screened, and 44 patients with single medicine were enrolled (median 72.0 years-old). Blood samples were obtained at 1 and 2 weeks after the medication started. The extent of anticoagulation activity, inflammatory markers and platelet aggregation were assessed. Patients with antiplatelets were used as control. RESULTS: Prescribed antithrombotics were dabigatran (group D: n = 12), apixaban (group A: n = 14) and antiplatelet agents (group P: n = 18). Prevalence of stroke risks and anticoagulation activity were not different between groups D and A. The alteration of inflammatory markers in a week in the group A showed similar trend to those in the group P. The group D presented relatively lower amount of high-sensitive C-reactive protein and higher amount of pentraxin-3 compared with groups A and P. While 88.9% of group P patients showed decreased platelet aggregation activity with adenosine diphosphate, 55.6% of group D and 40.0% of group A presented the inhibition of platelet aggregation activity. CONCLUSIONS: Even in acute ischemic stroke patients, both apixaban and dabigatran equally showed the anticoagulation activity. The reduction of inflammatory response might be prominent in apixaban, whereas the inhibition of platelet aggregation activity might be evident in dabigatran.

  30. Clinical features of patients who died within 24 h after admission to a stroke care center. 国際誌 査読有り

    Masahiro Sasaki, Hiroshi Okudera, Taizen Nakase, Akifumi Suzuki

    The Journal of international medical research　45　(6)　1848-1860　2017年12月

    DOI： 10.1177/0300060516666754 　

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    Objective In Japan, stroke care is provided through medical cooperation and standardized treatment. However, various factors affect mortality in the hyperacute phase. The present study investigated factors associated with death within 24 h after admission for acute stroke. Methods Among 2335 patients admitted within 24 h after stroke onset from 1 January 2007 to 31 December 2012, a total of 139 deaths occurred. Forty-eight deaths occurred within 24 h after admission. We retrospectively examined the clinical features of these 48 patients. Results The overall mortality rate was 6.0%. When the initial 72-h period was divided into ≤24 h (Period I), >24 to 48 h (Period II), and >48 to 72 h (Period III), deaths were significantly more frequent in Period I than in the other two periods. The frequency of intracerebral haemorrhage (ICH) was also significantly higher in Period I than in the other two periods. Factors significantly associated with death from ICH were systolic blood pressure, hematoma volume, and surgery. Conclusion The mortality rate was low among patients with stroke transported to the authors' medical center within 24 h of onset. Blood pressure management and the timing of determining indications for surgery are important factors in acute haemorrhagic stroke care.

  31. Effects With and Without Clopidogrel Loading Treatment for Acute Ischemic Cerebrovascular Disease Patients: A Retrospective Cohort Study. 国際誌 査読有り

    Yasuko Ikeda-Sakai, Masahiro Sasaki, Taizen Nakase

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association　26　(12)　2901-2908　2017年12月

    DOI： 10.1016/j.jstrokecerebrovasdis.2017.07.010 　

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    OBJECTIVES: We investigated the effectiveness of clopidogrel loading (CL) treatment compared with usual clopidogrel non-loading (NL) treatment for acute ischemic cerebrovascular disease. METHODS: We screened consecutive 1072 patients with ischemic cerebrovascular disease within 48 hours of symptom onset admitted to our hospital. Eligible patients were divided into the CL group (300 mg on day 1, followed by 50-75 mg once daily) and NL group (50-75 mg once daily). The incidence proportion of neurologic deterioration during hospitalization was compared between the 2 groups using logistic regression analysis. RESULTS: A total of 224 patients, 39 in CL group and 185 in NL group, were enrolled. The frequency of neurologic deterioration did not significantly differ between the 2 groups (risk ratio [95% confidence interval]: 1.47 [.88-2.46]). On the preset subgroup analysis according to stroke subtype, the frequency of neurologic deterioration in CL group was significantly higher in branch atheromatous disease (risk ratio: 2.44 [1.67-3.55]) and was not different statistically in transient ischemic attack (risk ratio: 0). The analysis adjusted by several confounders showed that the incidence proportion of neurologic deterioration was not significantly different in large artery atherosclerosis (adjusted odds ratio: 1.06 [.23-4.84]) as crude analysis. The incidence proportion of adverse events was not significantly different between the 2 groups. CONCLUSIONS: The effect of CL therapy differed by stroke subtypes in preventing neurologic deterioration. CL therapy appeared to be ineffective in branch atheromatous disease. Therefore, the choice of CL therapy should carefully be made according to stroke subtypes.

  32. An Autopsy Case of Early Onset Alzheimer's Disease with G378E Mutation in PSEN1 Showing Widespread Tau and A beta Pathologies 査読有り

    Hajime Miyata, Taizen Nakase, Takeshi Ikeuchi, Yasuji Yoshida

    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY　76　(6)　503-503　2017年6月

    ISSN：0022-3069

    eISSN：1554-6578

  33. Protective effects of connexins in atheromatous plaques in patients of carotid artery stenosis. 国際誌 査読有り

    Taizen Nakase, Tatsuya Ishikawa, Hajime Miyata

    Neuropathology : official journal of the Japanese Society of Neuropathology　37　(2)　97-104　2017年4月

    DOI： 10.1111/neup.12345 　

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    Fragility of atheromatous plaque in the internal carotid artery can be a risk of brain infarction. The activation of macrophages by oxidative stress and the vulnerability of vascular endothelial cells have been reported to participate in the fragility of atheromatous plaque. Therefore, from the view point of prevention of brain infarction, we investigated the pathological factors which may influence the stabilization of atheromatous plaque. Patients undertaking carotid endoarterectomy (CEA) were continuously screened. Then, 21 samples were obtained from the atheromatous plaques of CEA patients. The expression of connexin (Cx) which composes a gap junction, an intercellular communication organ, was immunohistochemicaly observed. The expression of CD36, an oxidized low-density lipoprotein receptor, was assessed as a marker of oxidative stress. As a result, asymptomatic plaques which were assumed the stable plaques expressed Cx43 along with CD36 expression. In contrast, in the symptomatic plaques, the expression of Cx43 was few and there was almost no coexpression with CD36. The distribution of Cx37 expression was not different between asymptomatic and symptomatic plaques. The expressions of CD36, Cx37 and Cx43 showed no relation to the previous treatment with statins. In conclusion, Cx43 might contribute to the stabilization of atheromatous plaque which is affected by oxidative stress.

  34. 進行性脳梗塞の病態とその治療について

    中瀬 泰然, 佐々木 正弘, 鈴木 明文

    秋田県医師会雑誌　67　(1)　7-13　2017年2月

    出版者・発行元： (一社)秋田県医師会

    ISSN：0286-7656

  35. Cerebral circulation in aging. 国際誌 査読有り

    Ken Nagata, Takashi Yamazaki, Daiki Takano, Tetsuya Maeda, Yumi Fujimaki, Taizen Nakase, Yuichi Sato

    Ageing research reviews　30　49-60　2016年9月

    DOI： 10.1016/j.arr.2016.06.001 　

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    Cerebral circulation is known to be protected by the regulatory function against the hypoperfusion that will affect the cognitive function as a result of brain ischemia and energy failure. The regulatory function includes cerebrovascular autoregulation, chemical control, metabolic control, and neurogenic control, and those compensatory mechanisms can be influenced by hypertension, atherosclerosis, cardiac diseases, cerebrovascular diseases and aging. On the other hand, large and/or small infarction, intracranial hemorrhage, subarachnoid hemorrhage, atherosclerosis, amylod angiopathy are also more directly associated with cognitive decline not only in those with vascular cognitive impairment or vascular dementia but also those with Alzheimer's disease.

  36. Outstanding Symptoms of Poststroke Depression during the Acute Phase of Stroke. 国際誌 査読有り

    Taizen Nakase, Maiko Tobisawa, Masahiro Sasaki, Akifumi Suzuki

    PloS one　11　(10)　e0163038　2016年

    DOI： 10.1371/journal.pone.0163038 　

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    Poststroke depression (PSD) is a critical complication which might lead to unfavorable outcomes. However, most cases of PSD in the acute phase, during the 2 or 3 weeks following a stroke, are neglected because of the variable comorbid conditions. In this study, aimed at revealing the outstanding symptoms of PSD during the acute phase, consecutive patients with intracranial hemorrhage (ICH) or brain infarction (BI) were asked to fill out a depression questionnaire (Quick Inventory of Depressive Symptomatology Self-Report: QIDS-SR) at 1 week and 1 month following stroke onset. Patients with disturbed consciousness or aphasia were excluded from this study. Forty-nine ICH patients and 222 BI patients completed the QIDS-SR at 1 week and 27 of ICH and 62 of BI at 1 month. The PSD rate was 67% and 46% at 1 week in ICH and BI, respectively. Although sleep disturbance was the most frequent symptom of PSD, psychomotor agitation and appetite disturbance were the most distinguishing symptoms in ICH at 1 week and fatigue at 1 month. On the other hand, most of the depressive symptoms addressed in QIDS-SR were observed in PSD of BI patients both at 1 week and 1 month. In conclusion, while sleep disturbance was a frequent but non-specific symptom, appetite disturbance and fatigue might be critical symptoms to suggest PSD during the acute phase of stroke.

  37. Eicosapentaenoic Acid as long-term secondary prevention after ischemic stroke. 国際誌 査読有り

    Taizen Nakase, Masahiro Sasaki, Akifumi Suzuki

    Clinical and translational medicine　4　(1)　62-62　2015年12月

    DOI： 10.1186/s40169-015-0062-5 　

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    BACKGROUND: It is sometimes difficult to choose anti-thrombotic agents for secondary prevention in stroke patients at high bleeding risk. Recently, Eicosapentaenoic Acid (EPA) was reported to reduce the recurrence of stroke in hypercholesterolemic patients without increasing hemorrhagic risk. In this study, we investigated the features of recurrent stroke patients during EPA medication as secondary stroke prevention. METHODS: Following the approval of the ethical committee, stroke patients in the outpatient clinic were consecutively screened and patients who continuously take EPA were enrolled in this study (n = 71, average age 69.7 yo). Blood sample data was adopted from the latest visit or the admission at the stroke recurrence. According to the previous stroke history, all patients were classified into the hemorrhagic stroke (HS) group (n = 10) and the ischemic stroke, including asymptomatic infarction, (IS) group (n = 61). RESULT: Any stroke recurrence was not observed in the HS group. Whereas, ischemic stroke recurrence was observed in 6 patients in the IS group, although there was no hemorrhagic stroke recurrence. Recurrent stroke patients showed the higher serum level of cholesterol or the renal dysfunction. The stroke subtype of patients were 2 embolic strokes, 3 atherothrombotic infarctions (two were compromised with renal failure and one had insufficient amount of EPA) and one lacunar infarction (who showed high triglyceride level). CONCLUSION: Hemorrhagic stroke was not occurred in our observation of EPA prescribed patients. The clinical features of recurrent stroke patients were the existing complications of dyslipidemia and renal dysfunction.

  38. The Impact of Diagnosing Branch Atheromatous Disease for Predicting Prognosis. 国際誌 査読有り

    Taizen Nakase, Yasumasa Yamamoto, Makoto Takagi

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association　24　(10)　2423-8　2015年10月

    DOI： 10.1016/j.jstrokecerebrovasdis.2015.06.044 　

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    BACKGROUND: We had reported that, in the acute phase of the brain penetrating artery infarction, patients with branch atheromatous disease (BAD) tended to be worsened compared with the lacunar infarction (LI). Because no prospective study has been reported, we composed a multicenter study (Japan Branch Atheromatous Disease [J-BAD] Registry) in which patients of penetrating artery infarction were prospectively enrolled for exploring the clinical features of BAD. METHODS: From the associated 9 hospitals, acute ischemic stroke patients were asked to be enrolled in the J-BAD Registry and classified into the lenticulostriate arterial (LSA) infarction (n = 124) and the pontine penetrating arterial (PPA) infarction (n = 42) groups. The clinical courses and the repeated magnetic resonance imaging findings were investigated. RESULTS: Neurologic worsening was observed at a significantly higher rate in BAD compared with the LI patients in both the LSA and PPA groups (P < .01, 45.1% versus 22.6% and 46.7% versus 0%, respectively). In the LSA group, the enlargement of the ischemic lesion was significantly more frequent in BAD compared with the LI patients (P < .01, 66.2% and 34.0%, respectively). There was a significant relation between the enlargement of the lesion and the worsening of neurologic deficits (P < .001). Moreover, the clinical features, which predict the lesion enlargement, were BAD and older age. CONCLUSIONS: LSA infarction of BAD diagnosis or older age patients might show an increase of lesion size and a tendency of neurologic worsening. It could be important to discriminate BAD from other ischemic stroke subtypes, in regard to the prediction of prognosis.

  39. Do the antithrombotic therapy at the time of intracerebral hemorrhage influence clinical outcome? analysis between the difference of antiplatelet and anticoagulant agents and clinical course. 国際誌 査読有り

    Takeshi Okada, Taizen Nakase, Masahiro Sasaki, Tatsuya Ishikawa

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association　23　(7)　1781-8　2014年8月

    DOI： 10.1016/j.jstrokecerebrovasdis.2014.04.036 　

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    BACKGROUND: It is controversial whether taking antiplatelet agents (APs) or anticoagulant agents (ACs) could influence clinical outcome after intracerebral hemorrhage (ICH). METHODS: We retrospectively investigated 557 ICH patients between September 2008 and August 2013. We reviewed patients' characteristics, hematoma volume, deterioration (hematoma expansion, surgical hematoma evacuation, or death), and clinical outcome in modified Rankin Scale. RESULTS: A total of 397 were classified as neither AP nor AC ("Nothing"), 81 as single AP (44 as aspirin [ASA], 22 as clopidogrel or ticlopidine [CLP/TIC], 7 as cilostazol, 8 as dual antiplatelet therapy), 43 as single AC (40 as warfarin, 2 as rivaroxaban, 1 as dabigatran), and 36 as both AP and AC (AP + AC). The clinical outcome was worse in APs than in "Nothing" (P = .021). Among APs, CLP/TIC showed poorer clinical outcome than ASA (P = .020). Deterioration was observed more frequently in AC than in "Nothing" (P < .001) and the clinical outcome was also worse in AC than in "Nothing" (P < .001). AP + AC use resulted in deterioration more frequently than "Nothing" (P < .001) and in poorer outcome than in "Nothing" (P < .001). CONCLUSIONS: The use of antithrombotic agents could be associated with the deterioration after admission and the poor clinical outcome. CLP/TIC use may affect the poor outcome compared with ASA use.

  40. The effect of acute medication with cilostazol, an anti-platelet drug, on the outcome of small vessel brain infarction. 国際誌 査読有り

    Taizen Nakase, Masahiro Sasaki, Akifumi Suzuki

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association　23　(6)　1409-15　2014年7月

    DOI： 10.1016/j.jstrokecerebrovasdis.2013.11.023 　

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    Our objective was to investigate the effect of cilostazol in acute therapy for small vessel stroke patients. The neurologic deficits in some patients of small vessel brain infarction will progress even if a patient takes immediate medical treatments including aspirin or other antiplatelet drugs. In Japan, cilostazol, presenting not only the antiplatelet effect but also the arteriole dilation, is used for treatment of ischemic stroke. In this study, acute stroke patients with small vessel occlusion were treated with cilostazol instead of aspirin in the conventional medication after 2010. Therefore, patients between April 2007 and March 2009 were classified into the conventional group (group-con, n=220), and patients between April 2010 and March 2012 were classified into the cilostazol group (group-cilo, n=230). Enrolled patients were classified into lacunar infarction (LI) and branch atheromatous disease. Progressing stroke was defined as the increase of National Institutes of Health Stroke Scale score of 2 or more within 48 hours. The clinical outcome was assessed by the modified Rankin Scale (mRS) score at 1 month. As the result, the significant reduction in progressing stroke was dominant in the LI of brainstem (P=.01). The length of hospital stay was significantly shorter in the group-cilo compared with the group-con (18.6 and 21.2 days, P=.03). Moreover, mRS score at 1 month was significantly lower in the group-cilo than the group-con (1.9 and 2.3, P=.03). In conclusion, cilostazol reduced the risk of early neurologic deterioration of patients with small vessel brain infarction. It is eagerly desired to conduct a large randomized control trial.

  41. Progressing small vessel pontine infarction includes different etiologies. 国際誌 査読有り

    Taizen Nakase, Masahiro Sasaki, Yasuko Ikeda, Akifumi Suzuki

    Annals of clinical and translational neurology　1　(2)　75-9　2014年2月

    DOI： 10.1002/acn3.25 　

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    BACKGROUND: The aim of this study was to investigate the clinical features of progressing stroke of pontine infarction as small vessel disease. METHODS: Enrolled 38 acute pontine infarctions were confirmed by magnetic resonance imaging and magnetic resonance angiography at the first and seventh days. Ten patients (26.3%) presented progression (NIH Stroke Scale ≥2 increase within 72 h). RESULTS: Progressing patients showed no relation to the size and the distribution of lesion. Expansion of ischemic lesion showed correlation with basilar artery atherosclerosis. Stable lesion related to delayed worsening. CONCLUSION: These findings suggest that progressing stroke may be caused by not only the worsening of blood flow of ischemic lesion but also delayed neuronal death.

  42. 急性期虚血性脳血管障害患者へのクロピドグレルローディング治療

    池田 靖子, 中瀬 泰然, 佐々木 正弘, 吉岡 正太郎

    臨床神経学　53　(12)　1474-1474　2013年12月

    出版者・発行元： (一社)日本神経学会

    ISSN：0009-918X

    eISSN：1882-0654

  43. 脳出血発症後早期に認知障害を引き起こす要因についての検討

    中瀬 泰然, 佐々木 正弘, 吉岡 正太郎, 池田 靖子, 鈴木 明文

    臨床神経学　53　(12)　1549-1549　2013年12月

    出版者・発行元： (一社)日本神経学会

    ISSN：0009-918X

    eISSN：1882-0654

  44. The lower safety level of blood pressure evaluated by 123I-IMP single-photon emission computed tomography in acute cerebral infarction patients 査読有り

    Taizen Nakase, Shotaroh Yoshioka, Masahiro Sasaki, Akifumi Suzuki

    Clinical Practice　10　(4)　535-543　2013年7月

    DOI： 10.2217/cpr.13.28 　

    ISSN：2044-9038 2044-9046

  45. Risk of cognitive impairment in acute phase of intracerebral haemorrhage. 国際誌 査読有り

    Taizen Nakase, Masahiro Sasaki, Shotaroh Yoshioka, Yasuko Ikeda, Akifumi Suzuki

    International journal of stroke : official journal of the International Stroke Society　8　(4)　E15　2013年6月

    DOI： 10.1111/ijs.12104 　

  46. Clinical evaluation of lacunar infarction and branch atheromatous disease. 国際誌 査読有り

    Taizen Nakase, Shotaroh Yoshioka, Masahiro Sasaki, Akifumi Suzuki

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association　22　(4)　406-12　2013年5月

    DOI： 10.1016/j.jstrokecerebrovasdis.2011.10.005 　

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    Patients with branch atheromatous disease (BAD) are more likely to experience neurologic deficits compared with those with lacunar infarction (LI), although both disorders are forms of intracranial deep brain infarction. We clinically evaluated patients with BAD (n = 42) and LI (n = 57) to investigate why patients with BAD tend to experience progressing stroke. Patients presenting to our hospital with acute ischemic stroke between April 2008 and March 2009 were screened. LI was defined as an intracerebral lesion <15 mm in diameter and fewer than 3 slices or a lesion within the pontine parenchyma. BAD was defined as an intracerebral lesion of ≥ 15 mm in diameter and more than 3 slices or a lesion extending to the surface of the pontine base observed on diffusion-weighted magnetic resonance imaging. Progressing stroke was defined as a >2-point increase in the National Institutes of Health Stroke Scale within 48 hours of stroke onset. Progressing stroke was significantly more prevalent in the BAD group compared with the LI group (38.1% vs 12.3%). Diabetes mellitus with a high low-density lipoprotein level was significantly prevalent in patients with progressing BAD. When BAD in the cerebrum and BAD in the pons were analyzed separately, a low-density lipoprotein level >140 mg/dL was the most prevalent risk factor for progressing BAD in the cerebrum, and patient age was the strongest risk factor for progressing BAD in the pons. Vascular lesions asvsessed by magnetic resonance angiography were significantly abundant in both progressing LI and BAD. Our findings suggest that BAD may have a poorer prognosis than LI. Poorly controlled diabetes and hyperlipidemia could lead to atherosclerosis of the branch artery, resulting in worsening of BAD.

  47. 脳卒中後の肺塞栓症

    岡田 健, 中瀬 泰然, 佐々木 正弘, 吉岡 正太郎, 鈴木 明文

    脳卒中　35　(1)　5-11　2013年

    出版者・発行元： 一般社団法人 日本脳卒中学会

    DOI： 10.3995/jstroke.35.5 　 10.2169/internalmedicine.3285-19_references_DOI_UXXfTf9559yxfRXaPCt2D2KTrDc 　

    ISSN：0912-0726

    eISSN：1883-1923

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    要旨：急性期脳卒中患者で肺塞栓症(PE)と診断された27例を対象とし，その臨床的特徴を検討した．原疾患は脳梗塞12例(0.25%)，脳出血12例(0.94%)，くも膜下出血(SAH)3例(0.59%)であり，死亡はそれぞれ3例(25%)，3例(25%)，1例(33%)であった．入院時NIHSSの中央値(四分位置)は脳梗塞で13.0(10.0～21.5)，脳出血で17.5(16.0～23.3)とばらつきが多いが比較的高値であった．PE発症の中央値は8日から13.5日であった．発症時神経学的にはSAHは運動麻痺を認めていなかったが，脳出血，脳梗塞ではいずれも麻痺の強い症例に多く，日常生活動作レベルはベッド上が77.8%であった．過去の報告と比べてPEの発症率はほぼ横ばいであった．PEは抗血栓療法を行いにくい脳出血の方が高頻度であった．死亡率は依然高値であり，麻痺の重度な症例は入院後早期からの予防対策を考える必要がある．

  48. 超急性期血栓溶解療法における炎症反応の変化について 通常治療との比較検討

    中瀬 泰然, 吉岡 正太郎, 池田 靖子, 佐々木 正弘, 鈴木 明文

    臨床神経学　52　(12)　1422-1422　2012年12月

    出版者・発行元： (一社)日本神経学会

    ISSN：0009-918X

    eISSN：1882-0654

  49. 退院時mRS 0の虚血性脳卒中患者の臨床的特徴

    池田 靖子, 吉岡 正太郎, 佐々木 正弘, 中瀬 泰然

    臨床神経学　52　(12)　1571-1571　2012年12月

    出版者・発行元： (一社)日本神経学会

    ISSN：0009-918X

    eISSN：1882-0654

  50. 超急性期血栓溶解療法におけるエダラボンの効果についての検討

    中瀬 泰然, 吉岡 正太郎, 佐々木 正弘, 池田 靖子, 鈴木 明文

    東北脳血管障害研究会学術集会記録集　34回　84-95　2012年12月

    出版者・発行元： サノフィ(株)仙台オフィス

    ISSN：1880-9278

  51. Cerebrovascular lesions in elderly Japanese patients with Alzheimer's disease. 国際誌 査読有り

    Ken Nagata, Daiki Takano, Takashi Yamazaki, Tetsuya Maeda, Yuichi Satoh, Taizen Nakase, Yasuko Ikeda

    Journal of the neurological sciences　322　(1-2)　87-91　2012年11月15日

    DOI： 10.1016/j.jns.2012.07.001 　

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    OBJECTIVE: Cerebrovascular lesions (CVLs) are known to play important roles in the pathophysiology underlying Alzheimer's disease (AD), especially in elderly AD cases. The present study was conducted to elucidate the relationship between the CVLs and vascular risk factors (VRFs) in elderly Japanese patients with AD. SUBJECTS AND METHODS: The CVLs such as lacunar infarcts, old microbleeds (OMBs), white matter lesions (WMLs), and occlusive vascular lesions on MRI were analyzed in relation to the risk factors in 120 Japanese patients with probable AD. Their mean age was 75.6 years. The subjects were divided into two age groups: young-old group (YOG) consisting of 55 cases being younger than 75 years and old-old group (OOG) consisting of 65 cases being 75 years or older. RESULTS: In overall analysis, 10 cases (8.3%) showed brain atrophy without CVLs on MRI, 46 cases (38.3%) showed WMLs in addition to the brain atrophy, 61 cases (50.8%) showed lacunar lesions, and 3 cases (2.5%) were diagnosed as having a superficial siderosis. Lacunar infarcts and OMBs were more frequently observed in OOG than in YOG, and were also more frequently observed in those with 2 or more VRFs than those with less than 2 VRFs (p<0.05). The WMLs were more pronounced in OOG, and in those with more VRFs. CONCLUSION: The CVLs including lacunes, WMLs, and OMBs were present more than 90% of elderly Japanese patients with AD. As the severity of CVLs was associated with VRFs and age, VRFs may modify clinical presentation of elderly AD patients.

  52. 【アルツハイマー病のNMDAアンタゴニストによる薬物療法】NMDA受容体拮抗薬メマンチンの薬理作用とアルツハイマー病における臨床効果

    長田 乾, 高野 大樹, 山崎 貴史, 前田 哲也, 佐藤 雄一, 池田 靖子, 中瀬 泰然

    脳21　15　(4)　474,407-486,407　2012年10月

    出版者・発行元： (株)金芳堂

    ISSN：1344-0128

  53. 【新しいアルツハイマー型認知症治療薬の使用経験】メマンチンの使用経験 アルツハイマー病におけるメマンチンの臨床効果

    長田 乾, 高野 大樹, 山崎 貴史, 前田 哲也, 佐藤 雄一, 池田 靖子, 中瀬 泰然

    老年精神医学雑誌　23　(9)　1074-1078　2012年9月

    出版者・発行元： (株)ワールドプランニング

    ISSN：0915-6305

  54. 【脳卒中診療のトピックス】脳内出血治療の現状と展望

    吉岡 正太郎, 鈴木 明文, 石川 達哉, 中瀬 泰然

    救急医学　36　(8)　950-954　2012年8月

    出版者・発行元： (株)へるす出版

    ISSN：0385-8162

  55. Clinical features of recurrent stroke after intracerebral hemorrhage. 国際誌 査読有り

    Taizen Nakase, Shotaroh Yoshioka, Masahiro Sasaki, Akifumi Suzuki

    Neurology international　4　(2)　e10　2012年6月14日

    DOI： 10.4081/ni.2012.e10 　

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    There have been many reports about the prognosis and risk factors of stroke recurrence following brain infarction (BI). However, little is known about the stroke recurrence after primary intracerebral hemorrhage (PICH). Therefore, we explored the recurrent stroke patients after initial PICH retrospectively, to reveal the critical factors of stroke recurrence. Acute BI (n=4013) and acute PICH patients (n=1067) admitted to the hospital between April 2000 and March 2009 were consecutively screened. PICH patients with a history of ICH and BI patients with a history of ICH were then classified into the ICH-ICH group (n=64, age 70.8±9.5 years) and ICH-BI group (n=52, age 72.8±9.7years), respectively. ICH lesions were categorized into ganglionic and lober types according to the brain magnetic resonance imaging. Subtypes of BI were classified into cardioembolism, large-artery atherosclerosis, small-artery occlusion and others. There was no difference in incidence of risk factors between ICH-ICH and ICH-BI groups. Distribution of initial PICH lesions was significantly abundant in the lobar type in the ICH-ICH group (P<0.01) and in ganglionic type in the ICH-BI group (P<0.02). Age of onset was significantly older in recurrent lobar ICH compared with recurrent ganglionic ICH (P<0.01: 73.6±10.0 and 59.1±9.0 years, respectively). In conclusion, ganglionic ICH patients may have a chance of recurrent stroke in both brain infarction and ganglionic ICH, suggesting the participation of atherosclerosis in intracranial arteries. Lobar ICH patients were older and prone to recurrent lobar ICH, suggesting the participation of cerebral amyloid angiopathy as a risk of stroke recurrence.

  56. 【心房細動の脳梗塞予防-心と脳からの新たなる展開】心原性脳塞栓の病態と予防戦略

    長田 乾, 高野 大樹, 前田 哲也, 山崎 貴史, 中瀬 泰然, 池田 靖子, 佐藤 雄一

    成人病と生活習慣病　42　(5)　501-507　2012年5月

    出版者・発行元： (株)東京医学社

    ISSN：1347-0418

  57. 脳梗塞急性期における安全な血圧レベルは? SPECTによる脳血流量の評価から

    中瀬 泰然, 吉岡 正太郎, 佐々木 正弘, 鈴木 明文

    臨床神経学　51　(12)　1321-1321　2011年12月

    出版者・発行元： (一社)日本神経学会

    ISSN：0009-918X

    eISSN：1882-0654

  58. Musical anhedonia: selective loss of emotional experience in listening to music. 国際誌 査読有り

    Masayuki Satoh, Taizen Nakase, Ken Nagata, Hidekazu Tomimoto

    Neurocase　17　(5)　410-7　2011年10月

    DOI： 10.1080/13554794.2010.532139 　

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    Recent case studies have suggested that emotion perception and emotional experience of music have independent cognitive processing. We report a patient who showed selective impairment of emotional experience only in listening to music, that is musical anhednia. A 71-year-old right-handed man developed an infarction in the right parietal lobe. He found himself unable to experience emotion in listening to music, even to which he had listened pleasantly before the illness. In neuropsychological assessments, his intellectual, memory, and constructional abilities were normal. Speech audiometry and recognition of environmental sounds were within normal limits. Neuromusicological assessments revealed no abnormality in the perception of elementary components of music, expression and emotion perception of music. Brain MRI identified the infarct lesion in the right inferior parietal lobule. These findings suggest that emotional experience of music could be selectively impaired without any disturbance of other musical, neuropsychological abilities. The right parietal lobe might participate in emotional experience in listening to music.

  59. 薬物療法

    長田 乾, 高野 大樹, 山崎 貴史, 前田 哲也, 佐藤 雄一, 中瀬 泰然

    日本内科学会雑誌　100　(8)　2134-2145　2011年8月10日

    出版者・発行元： The Japanese Society of Internal Medicine

    DOI： 10.2169/naika.100.2134 　

    ISSN：0021-5384

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    アミロイド仮説に基づいた認知症の根本治療薬は，開発中止が相次ぎ，未だ臨床に供するまでには至っていない．認知症の中核症状の治療は，我が国では長年にわたりドネペジルが唯一の治療薬であったが，ガランタミン，メマンチン，リバスチグミンが漸く承認され，治療の選択肢が拡大した．周辺症状（BPSD）の治療には，抗精神病薬には保険適応がなく副作用の面からも制約があり，抑肝散やバルプロ酸の臨床治験が行われている．<br>

  60. Free radical scavenger, edaravone, reduces the lesion size of lacunar infarction in human brain ischemic stroke. 国際誌 査読有り

    Taizen Nakase, Shotaroh Yoshioka, Akifumi Suzuki

    BMC neurology　11　39-39　2011年3月30日

    DOI： 10.1186/1471-2377-11-39 　

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    BACKGROUND: Although free radicals have been reported to play a role in the expansion of ischemic brain lesions, the effect of free radical scavengers is still under debate. In this study, the temporal profile of ischemic stroke lesion sizes was assessed for more than one year to evaluate the effect of edaravone which might reduce ischemic damage. METHODS: We sequentially enrolled acute ischemic stroke patients, who admitted between April 2003 and March 2004, into the edaravone(-) group (n = 83) and, who admitted between April 2004 and March 2005, into the edaravone(+) group (n = 93). Because, edaravone has been used as the standard treatment after April 2004 in our hospital. To assess the temporal profile of the stroke lesion size, the ratio of the area [T2-weighted magnetic resonance images (T2WI)/iffusion-weighted magnetic resonance images (DWI)] were calculated. Observations on T2WI were continued beyond one year, and observational times were classified into subacute (1-2 months after the onset), early chronic (3-6 month), late chronic (7-12 months) and old (≥13 months) stages. Neurological deficits were assessed by the National Institutes of Health Stroke Scale upon admission and at discharge and by the modified Rankin Scale at 1 year following stroke onset. RESULTS: Stroke lesion size was significantly attenuated in the edaravone(+) group compared with the edaravone(-) group in the period of early and late chronic observational stages. However, this reduction in lesion size was significant within a year and only for the small-vessel occlusion stroke patients treated with edaravone. Moreover, patients with small-vessel occlusion strokes that were treated with edaravone showed significant neurological improvement during their hospital stay, although there were no significant differences in outcome one year after the stroke. CONCLUSION: Edaravone treatment reduced the volume of the infarct and improved neurological deficits during the subacute period, especially in the small-vessel occlusion strokes.

  61. ラクナ梗塞とBranch Atheromatous Diseaseの臨床的特徴 症状進行性の有無からの検討

    中瀬 泰然, 吉岡 正太郎, 鈴木 明文

    臨床神経学　50　(12)　1240-1240　2010年12月

    出版者・発行元： (一社)日本神経学会

    ISSN：0009-918X

    eISSN：1882-0654

  62. 【脳内出血のすべて 2009】急性期管理 高血圧性脳出血において入院時の高血圧は急性期の不良の転帰と関連する

    吉岡 正太郎, 武藤 達士, 師井 淳太, 中瀬 泰然, 鈴木 明文, 石川 達哉

    The Mt. Fuji Workshop on CVD　28　31-34　2010年7月

    出版者・発行元： The Mt. Fuji Workshop on CVD事務局

    ISSN：0289-8438

  63. 脳卒中におけるクリティカルパス 脳卒中急性期治療におけるクリティカルパス

    鈴木 明文, 中瀬 泰然, 師井 淳太, 吉岡 正太郎, 武藤 達士, 泉 学, 高見 彰淑, 皆方 伸

    日本医療マネジメント学会雑誌　11　(Suppl.)　136-136　2010年6月

    出版者・発行元： (NPO)日本医療マネジメント学会

    ISSN：1881-2503

    eISSN：1884-6807

  64. Ischemia alters the expression of connexins in the aged human brain. 国際誌 査読有り

    Taizen Nakase, Tetsuya Maeda, Yasuji Yoshida, Ken Nagata

    Journal of biomedicine & biotechnology　2009　147946-147946　2009年

    DOI： 10.1155/2009/147946 　

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    Although the function of astrocytic gap junctions under ischemia is still under debate, increased expression of connexin 43 (Cx43) has been observed in ischemic brain lesions, suggesting that astrocytic gap junctions could provide neuronal protection against ischemic insult. Moreover, different connexin subtypes may play different roles in pathological conditions. We used immunohistochemical analysis to investigate alterations in the expression of connexin subtypes in human stroke brains. Seven samples, sectioned after brain embolic stroke, were used for the analysis. Data, evaluated semiquantitatively by computer-assisted densitometry, was compared between the intact hemisphere and ischemic lesions. The results showed that the coexpression of Cx32 and Cx45 with neuronal markers was significantly increased in ischemic lesions. Cx43 expression was significantly increased in the colocalization with astrocytes and relatively increased in the colocalization with neuronal marker in ischemic lesions. Therefore, Cx32, Cx43, and Cx45 may respond differently to ischemic insult in terms of neuroprotection.

  65. The impact of inflammation on the pathogenesis and prognosis of ischemic stroke 査読有り

    Taizen Nakase, Takashi Yamazaki, Naoko Ogura, Akifumi Suzuki, Ken Nagata

    JOURNAL OF THE NEUROLOGICAL SCIENCES　271　(1-2)　104-109　2008年8月

    DOI： 10.1016/j.jns.2008.03.020 　

    ISSN：0022-510X

  66. 両側視床梗塞の症状, 病因, 予後に対する臨床的検討

    中瀬 泰然, 小倉 直子, 前田 哲也, 山崎 貴史, 亀田 知明, 佐藤 雄一, 長田 乾

    脳卒中　30　(4)　557-561　2008年7月25日

    出版者・発行元： The Japan Stroke Society

    DOI： 10.3995/jstroke.30.557 　

    ISSN：0912-0726

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    目的：視床梗塞において臨床症状と血管支配を含めた解剖学的構築との関連については様々な報告がある．本研究では急性期両側視床梗塞を呈した連続症例を検討し，臨床像および予後規定因子について解析した．<br> 方法：2001年4月∼2005年3月に入院した脳梗塞症例のうち，入院時MRIおよびMRAにて病巣と血管病変を同定し得た両側視床梗塞9例を対象とした．予後は退院時mRSにて判定した．<br> 結果：予後良好例（mRS 0∼2）5例，不良例（mRS 4以上）4例であった．予後良好例で記銘力低下，失見当識，過眠傾向などの精神症状が認められ，予後不良例では四肢麻痺，動眼神経麻痺，球麻痺が認められた．予後不良例の特徴として，脳幹・小脳梗塞の合併，発症時高齢（72.0±15.3歳vs 58.2±11.9歳）と，脳底動脈閉塞が観察された．<br> 結論：高齢発症，脳底動脈閉塞の有無が予後規定因子となりうることが示唆された．<br>

  67. 両側視床梗塞の臨床像と予後

    中瀬 泰然, 鈴木 明文, 佐藤 雄一, 前田 哲也, 山崎 貴史, 小倉 直子, 亀田 知明, 長田 乾

    臨床神経学　47　(12)　1001-1001　2007年12月

    出版者・発行元： (一社)日本神経学会

    ISSN：0009-918X

    eISSN：1882-0654

  68. Angiotensinogen gene polymorphism as a risk factor for ischemic stroke 査読有り

    Taizen Nakase, Toshiki Mizuno, Sanae Harada, Kei Yamada, Tsunehiko Nishimura, Kotaro Ozasa, Yoshiyuki Watanabe, Ken Nagata

    Journal of Clinical Neuroscience　14　(10)　943-947　2007年10月

    DOI： 10.1016/j.jocn.2006.07.008 　

    ISSN：0967-5868

  69. Amplified expression of uncoupling proteins in human brain ischemic lesions 査読有り

    Taizen Nakase, Yasuji Yoshida, Ken Nagata

    NEUROPATHOLOGY　27　(5)　442-447　2007年10月

    DOI： 10.1111/j.1440-1789.2007.00815.x 　

    ISSN：0919-6544

  70. Clinical diagnosis of vascular dementia 査読有り

    Ken Nagata, Hirohiko Saito, Tomoyuki Ueno, Mika Sato, Taizen Nakase, Tetsuya Maeda, Yuichi Satoh, Hiromi Komatsu, Miyuki Suzuki, Yasushi Kondoh

    JOURNAL OF THE NEUROLOGICAL SCIENCES　257　(1-2)　44-48　2007年6月

    DOI： 10.1016/j.jns.2007.01.049 　

    ISSN：0022-510X

  71. 脳梗塞の病態に及ぼす炎症ストレスの影響

    中瀬 泰然, 山崎 貴史, 小倉 直子, 鈴木 明文, 長田 乾

    Pharma Medica　25　(4)　159-160　2007年4月

    出版者・発行元： (株)メディカルレビュー社

    ISSN：0289-5803

  72. rt-PA静注による急性期血栓溶解療法の問題点

    鈴木 明文, 吉岡 正太郎, 師井 淳太, 中瀬 泰然, 澤田 元史, 小倉 直子, 小林 紀方, 長田 乾, 佐藤 雄一, 前田 哲也

    脳卒中　29　(2)　253-253　2007年3月

    出版者・発行元： (一社)日本脳卒中学会

    ISSN：0912-0726

    eISSN：1883-1923

  73. 脳出血の発症および経過に対する血圧日内変動の影響

    中瀬 泰然, 亀田 知明, 山崎 貴史, 小倉 直子, 前田 哲也, 佐藤 雄一, 鈴木 明文, 長田 乾

    脳卒中　29　(2)　254-254　2007年3月

    出版者・発行元： (一社)日本脳卒中学会

    ISSN：0912-0726

    eISSN：1883-1923

  74. 延髄梗塞の病巣局在と画像診断

    山崎 貴史, 中瀬 泰然, 小倉 直子, 亀田 知明, 中村 洋佑, 前田 哲也, 佐藤 雄一, 齋藤 博彦, 鈴木 明文, 長田 乾

    脳卒中　29　(2)　352-352　2007年3月

    出版者・発行元： (一社)日本脳卒中学会

    ISSN：0912-0726

    eISSN：1883-1923

  75. 【急性期脳梗塞のガイドライン】rt-PA静注による急性期血栓溶解療法の問題点

    鈴木 明文, 師井 淳太, 中瀬 泰然, 吉岡 正太郎, 長田 乾, 佐藤 雄一, 前田 哲也, 澤田 元史, 小林 紀方, 小倉 直子, 泉 学

    脳と神経　58　(11)　931-936　2006年11月

    出版者・発行元： (株)医学書院

    ISSN：0006-8969

    eISSN：2185-405X

  76. [Subjects in the acute thrombolytic therapy by intravenous administration of rt-PA]. 査読有り

    Akifumi Suzuki, Junta Moroi, Taizen Nakase, Shoutaro Yoshioka, Ken Nagata, Yuuichi Sato, Tetsuya Maeda, Motoshi Sawada, Norikata Kobayashi, Naoko Ogura, Manabu Izumi

    No to shinkei = Brain and nerve　58　(11)　931-6　2006年11月

    ISSN：0006-8969

  77. Enhanced connexin 43 immunoreactivity in penumbral areas in the human brain following ischemia 査読有り

    Taizen Nakase, Yasuji Yoshida, Ken Nagata

    GLIA　54　(5)　369-375　2006年10月

    DOI： 10.1002/glia.20399 　

    ISSN：0894-1491

  78. [An epilepsy case presenting temporal aphonia and prosodic deficit with left hemiparesis]. 査読有り

    Taizen Nakase, Tetsuya Maeda, Akifumi Suzuki, Ken Nagata

    Rinsho shinkeigaku = Clinical neurology　46　(10)　718-21　2006年10月

    ISSN：0009-918X

    詳細を見る 詳細を閉じる

    A 53-year-old right-handed woman was admitted to a hospital with a seizure, exhibiting loss of consciousness and paroxysmal myoclonic movement. MRI showed no abnormalities of her brain. Electroencephalography revealed sporadic sharp and slow wave complexes, starting from the right central region. Cerebral perfusion SPECT revealed increased blood supply in the right hemisphere. She received diagnosis of epilepsy and was treated with phenytoin. After she regained her consciousness, she had no voice and presented with left hemiparesis which was interpreted to be Todd's palsy. She gradually recovered in using her voice, to full normalization of affective prosody in 11 days. The left hemiparesis recovered first in the upper and later in the lower extremities. Her symptoms could be interpreted to be vocal and prosodic disturbance, but not aphasia, because she could understand speach and communicate with writing. The lesions responsible for prosodic deficit are still controversial. The symptoms observed and the findings obtained may indicate that the deficiency of the affective prosody may be caused by the dysfunction of the medial surface of the non-dominant frontal lobe in this case.

  79. 【神経救急 意識障害は怖くない】超急性期脳梗塞治療の最前線

    中瀬 泰然, 鈴木 明文, 長田 乾

    内科　97　(5)　872-877　2006年5月

    出版者・発行元： (株)南江堂

    ISSN：0022-1961

    eISSN：2432-9452

  80. 超急性期脳梗塞に対するrt-PA投与認可を踏まえて 発症3時間以内のtPA静注による血栓溶解療法の転帰と問題点

    鈴木 明文, 師井 淳太, 佐藤 美佳, 上野 友之, 吉岡 正太郎, 中瀬 泰然, 澤田 元史, 泉 学, 小林 紀方, 長田 乾

    脳卒中　28　(1)　101-101　2006年3月

    出版者・発行元： (一社)日本脳卒中学会

    ISSN：0912-0726

    eISSN：1883-1923

  81. 穿通枝梗塞における運動麻痺悪化と治療法の有効性について

    小倉 直子, 鈴木 明文, 長田 乾, 佐藤 美佳, 師井 淳太, 中瀬 泰然, 吉岡 正太郎, 上野 友之, 斉藤 博彦, 澤田 元史

    脳卒中　28　(1)　117-117　2006年3月

    出版者・発行元： (一社)日本脳卒中学会

    ISSN：0912-0726

    eISSN：1883-1923

  82. 高血圧性被殻出血に対する定位的脳内血腫除去術

    師井 淳太, 鈴木 明文, 小林 紀方, 澤田 元史, 中瀬 泰然, 齋藤 博彦, 佐藤 美佳, 長田 乾

    脳卒中　28　(1)　136-136　2006年3月

    出版者・発行元： (一社)日本脳卒中学会

    ISSN：0912-0726

    eISSN：1883-1923

  83. 経過中に脳塞栓症を再発した椎骨動脈解離の1例

    中瀬 泰然, 鈴木 明文, 岡根 久美子, 長田 乾

    脳と神経　58　(3)　239-243　2006年3月

    出版者・発行元： (株)医学書院

    ISSN：0006-8969

    eISSN：2185-405X

  84. A case of vertebral artery dissection with recurrent brain embolism 査読有り

    Taizen Nakase, Akifumi Suzuki, Kumiko Okane, Ken Nagata

    Brain and Nerve　58　(3)　239-243　2006年3月

    ISSN：0006-8969

  85. Discrepancy between clinical and pathological diagnoses of CBD and PSP 査読有り

    Toshiki Mizuno, Kensuke Shiga, Yuriko Nakata, Junko Nagura, Taizen Nakase, Yoshihiro Ueda, Yoshiaki Takanashi, Kohji Urasaki, Yumiko Oyamada, Shinji Fushiki, Junji Nishikawa, Masahiro Yasuhara, Kenji Nakajima, Masanori Nakagawa

    Journal of Neurology　252　(6)　687-697　2005年6月

    DOI： 10.1007/s00415-005-0718-y 　

    ISSN：0340-5354

  86. tPAを用いた発症3時間以降の急性期血栓溶解療法 動注法と静注法の比較

    鈴木 明文, 師井 淳太, 佐藤 美佳, 長田 乾, 大楽 英明, 佐々木 正弘, 里見 淳一郎, 中瀬 泰然

    脳卒中　27　(1)　207-207　2005年4月

    出版者・発行元： (一社)日本脳卒中学会

    ISSN：0912-0726

    eISSN：1883-1923

  87. 初回症候性脳出血患者に認められるMicrobleedsの特徴について

    佐藤 美佳, 長田 乾, 鈴木 明文, 師井 淳太, 里見 淳一郎, 中瀬 泰然, 大楽 英明, 佐々木 正弘, 齋藤 博彦, 上野 友之

    脳卒中　27　(1)　216-216　2005年4月

    出版者・発行元： (一社)日本脳卒中学会

    ISSN：0912-0726

    eISSN：1883-1923

  88. 失声と失韻律を呈したてんかんの一症例

    中瀬 泰然, 前田 哲也, 佐藤 雄一, 佐藤 美佳, 斉藤 博彦, 上野 友之, 鈴木 明文, 長田 乾

    臨床神経学　45　(1)　70-70　2005年1月

    出版者・発行元： (一社)日本神経学会

    ISSN：0009-918X

    eISSN：1882-0654

  89. Ｍｉｃｒｏｂｌｅｅｄｓの有無による初回症候性脳出血患者の臨床的特徴

    佐藤 美佳, 長田 乾, 鈴木 明文, 師井 淳太, 佐々木 正弘, 中瀬 泰然, 大楽 英明

    脳卒中　27　(2)　299-303　2005年

    出版者・発行元： The Japan Stroke Society

    DOI： 10.3995/jstroke.27.299 　

    ISSN：0912-0726

    詳細を見る 詳細を閉じる

    初回症候性脳出血患者のMicrobleeds(MB)の有無で,臨床所見や画像所見の相違について検討した.174例中,MB陽性例は65.5%で,皮質・皮質下(39.6%)に最も多く認められた.MB陽性/陰性群の比較検討では,年齢,性差,高血圧,糖尿病,高脂血症,入院時血圧,入院時および退院時のJapan Stroke Scale,血腫量には有意差がなかった.MB陽性群では,抗血栓薬の内服,ラクナ梗塞数,Leuko-araiosis(LA)の重症度が有意に高値であった.ロジスティック解析では,LA重症度がオッズ比2.20でMBに対する独立した因子であった.今回の結果よりMBはラクナ梗塞,特にLAと関連が深いと考えられた.また,MB陽性群で抗血栓薬の内服が高率だったことから,抗血栓薬投与前にMBやLAを評価することで,抗血栓薬内服中の出血のリスクを軽減できる可能性が示唆された.

  90. Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes. 国際誌

    Taizen Nakase, Goran Söhl, Martin Theis, Klaus Willecke, Christian C G Naus

    The American journal of pathology　164　(6)　2067-75　2004年6月

    ISSN：0002-9440

    詳細を見る 詳細を閉じる

    Astrocytes secrete cytokines and neurotrophic factors to neurons, consistent with a neurosupportive role for astrocytes. However, in ischemic or metabolic insults, the function of astrocytic gap junctions composed mainly from connexin43 (Cx43) remains controversial. We have previously shown that heterozygous Cx43 null mice subjected to middle cerebral artery occlusion exhibited significantly enhanced stroke volume and apoptosis compared to wild-type mice. In this study, we used mice in which the human GFAP promoter-driven cre transgene deletes the floxed Cx43 gene in astrocytes, excluding the effects from reduced Cx43 expression in many other cell types as well as astrocytes. We induced focal brain ischemia in mice lacking Cx43 in astrocytes [Cre(+)] and control littermates [Cre(-)]. Cre(+) mice showed a significantly increased stroke volume and enhanced apoptosis, detected by terminal dUTP nick-end labeling and caspase-3 immunostaining, compared to Cre(-) mice. Inflammatory response assessed by the microglial marker CD11b was amplified in the penumbra of Cre(+) mice compared to that of Cre(-) mice. Our results suggest that astrocytic gap junctions could be important for the regulation of neuronal apoptosis and the inflammatory response after stroke. These findings support the view that astrocytes play a critical role in neuroprotection during ischemic insults.

  91. Gap junctions and neurological disorders of the central nervous system. 国際誌

    Taizen Nakase, Christian C G Naus

    Biochimica et biophysica acta　1662　(1-2)　149-58　2004年3月23日

    ISSN：0006-3002

    詳細を見る 詳細を閉じる

    Gap junctions are intercellular channels which directly connect the cytoplasm between neighboring cells. In the central nervous system (CNS) various kinds of cells are coupled by gap junctions, which play an important role in maintaining normal function. Neuronal gap junctions are involved in electrical coupling and may also contribute to the recovery of function after cell injury. Astrocytes are involved in the pathology of most neuronal disorders, including brain ischemia, Alzheimer's disease and epilepsy. In the pathology of brain tumors, gap junctions may be related to the degree of malignancy and metastasis. However, the role of connexins, gap junctions and hemichannels in the pathology of the diseases in the CNS is still ambiguous. Of increasing importance is the unraveling of the function of gap junctions in the neural cell network, involving neurons, astrocytes, microglia and oligodendrocytes. A better understanding of the role of gap junctions may contribute to the development of new therapeutic approaches to treating diseases of the CNS.

  92. Astrocytic gap junctions composed of connexin 43 reduce apoptotic neuronal damage in cerebral ischemia 査読有り

    Taizen Nakase, Shinji Fushiki, Christian C.G. Naus

    Stroke　34　(8)　1987-1993　2003年8月1日

    DOI： 10.1161/01.STR.0000079814.72027.34 　

    ISSN：0039-2499

  93. Neuroprotective role of astrocytic gap junctions in ischemic stroke 査読有り

    Taizen Nakase, Shinji Fushiki, Goran Söhl, Martin Theis, Klaus Willecke, Christian C.G. Naus

    Cell Communication and Adhesion　10　(4-6)　413-417　2003年7月

    ISSN：1541-9061

  94. A newly established neuronal ρ-0 cell line highly susceptible to oxidative stress accumulates iron and other metals: Relevance to the origin of metal ion deposits in brains with neurodegenerative disorders 査読有り

    Ryuichi Fukuyama, Akihiko Nakayama, Taizen Nakase, Hiroe Toba, Teruo Mukainaka, Hirofumi Sakaguchi, Takuya Saiwaki, Hiromu Sakurai, Mikio Wada, Shinji Fushiki

    Journal of Biological Chemistry　277　(44)　41455-41462　2002年11月1日

    DOI： 10.1074/jbc.M204176200 　

    ISSN：0021-9258

  95. 糖尿病と虚血性脳血管障害 糖尿病における梗塞巣の分布の特徴:糖尿病における梗塞巣の分布の特徴

    中瀬 泰然, 山本 康正, 大岩 海陽, 林 正道, 中島 健二

    脳卒中　22　(2)　335-342　2000年

    出版者・発行元： The Japan Stroke Society

    DOI： 10.3995/jstroke.22.335 　

    ISSN：0912-0726

    詳細を見る 詳細を閉じる

    糖尿病(DM)がどのような梗塞病変,脳血管病変に関連しているかを明らかにするため,心原性脳塞栓症を除く初発症候性虚血性脳疾患連続215例につき,各種危険因子とMRIによる症候性・無症候性脳梗塞巣の分布,脳血管撮影による血管病変との関連を検討した.DMで多く見られた梗塞型は脳幹梗塞橋底部に達するタイプ(branch atheromatous type:B型)であった(OR2.98,95%信頼区間1.41～6.29,p<0.01).脳幹梗塞深部小梗塞は高血圧(HT)と関連しDMとは関連しなかった.15mm以下の多発ラクナ梗塞は,基底核領域,視床領域ともHTと関連し,DMとは関連しなかった.DMと椎骨脳底動脈病変との関連は有意でなかった.DMとの明らかな関連は脳幹梗塞B型のみで,椎骨脳底動脈灌流領域の梗塞である脳幹深部小梗塞,視床梗塞,小脳梗塞とは有意に関連しなかった.

  96. 心臓・大血管手術待機症例における無症候性脳梗塞および脳血管病変と周術期リスク管理の検討

    牧野 雅弘, 永金 義成, 川越 知恵, 中瀬 泰然, 高安 奈津子, 中島 健二, 夜久 均, 北村 信夫, 塩貝 敏之

    脳卒中　22　(4)　570-575　2000年

    出版者・発行元： The Japan Stroke Society

    DOI： 10.3995/jstroke.22.570 　

    ISSN：0912-0726

    詳細を見る 詳細を閉じる

    Purpose and Method : In order to prevent stroke in perioperative period of cardiovascular surgery, we analyzed silent cerebrovascular factors. Seventy-seven patients with Coronary Artery Bypass Graft Surgery (CABG) and forty-three patients with other cardiac operations (non-CABG) were recruited and evaluated by MRI, MRA and cervical duplex ultra-sonography.<BR>Result : The frequency of the silent brain infarction in CABG group (49.4%) was not statistically significant from that in non-CABG group (41.9%). In both groups, almost all of lesions were lacunar infarctions locating in deep carebral white matter.<BR>Severe stenosis or occlusive lesions in intra and/or extracranial major arteries were more frequently found in CABG group than in non-CABG group (29.9% vs 11.6%, p=0.026). The intracranial vascular lesions rather than extracranial ones were more predominantly revealed in our series.<BR>Conclusion : To reduce the peri-and postoperative complications of patients underwent cardiovascular surgery, preoperative evaluation of stenotic vascular lesions in cervical and intracranial areas is very important.

  97. A Case of Medial Medullary Syndrome Detected by Diffusion weighted Magnetic Resonance Imaging 査読有り

    Tomomi Nakamura, Masahiro Makino, Toshihiko Ebisu, Taizen Nakase, Masahiro Umeda, Cyuzou Tanaka, Kenji Nakajima

    Brain and Nerve　51　(2)　145-148　1999年

    ISSN：0006-8969

  98. Clinical application of magnetoencephalography in a patient with corticobasal degeneration 査読有り

    Toshiki Mizuno, Yoshiaki Takanashi, Taizen Nakase, Masahiro Makino, Kazuhide Iwamoto, Kenji Nakajima, Seiichi Furuya, Shoji Naruse, Yoshio Imahori, Yoshikazu Yoshida

    Journal of Neuroimaging　9　(1)　45-47　1999年

    出版者・発行元： Lippincott Williams and Wilkins

    DOI： 10.1111/jon19999145 　

    ISSN：1051-2284

︎全件表示 ︎最初の5件までを表示

MISC 42

  1. 認知機能障害患者における難聴と脳構造の変化

    奈良林愛美, 舘脇康子, 大場健太郎, 白海雲, 野村脩子, 高野由美, 中瀬泰然, 永坂竜男, 瀧靖之, 瀧靖之

    Dementia Japan　38　(4)　2024年

    ISSN： 1342-646X

  2. 認知症患者における認知障害に対する心房細動の影響

    NAKASE Taizen, TATEWAKI Yasuko, TOMITA Naoki, ODAGIRI Hayato, TAKANO Yumi, MURANAK Michiho, TAKI Yasuyuki

    日本神経学会学術大会プログラム・抄録集　64th　2023年

  3. PERCEIVED SOCIAL ISOLATION IS CORRELATED WITH BRAIN STRUCTURE AND COGNITIVE TRAJECTORY IN ALZHEIMER'S DISEASE

    Ye Zhang, Yasuko Tatewaki, Yingxu Liu, Naoki Tomita, Yumi Takano, Taizen Nakase, Tatsushi Mutoh, Yasuyuki Taki

    INNOVATION IN AGING　6　772-773　2022年11月

    eISSN： 2399-5300

  4. コロナワクチン接種後に多臓器の障害が見られた高齢認知症の1例

    村中 美千帆, 冨田 尚希, 中瀬 泰然, 高野 由美, 山本 修三, 舘脇 康子, 武藤 達士, 瀧 靖之

    日本老年医学会雑誌　59　(4)　574-574　2022年10月

    出版者・発行元： (一社)日本老年医学会

    ISSN： 0300-9173

  5. 物忘れの自覚に関わる因子の検討

    張 よう, 冨田 尚希, 中瀬 泰然, 瀧 靖之

    日本老年医学会雑誌　59　(Suppl.)　133-133　2022年5月

    出版者・発行元： (一社)日本老年医学会

    ISSN： 0300-9173

  6. 老年科専門医育成の今後 老年科専門医が持つべき能力・理念

    冨田 尚希, 村中 美千帆, 高野 由美, 館脇 康子, 山本 修三, 中瀬 泰然, 武藤 達士, 瀧 靖之

    日本老年医学会雑誌　58　(Suppl.)　89-89　2021年5月

    出版者・発行元： (一社)日本老年医学会

    ISSN： 0300-9173

  7. 進行性脳梗塞を呈し緊急CASを施行した放射線治療後頸部頸動脈狭窄症の1例

    富樫 俊太郎, 高橋 佑介, 鈴木 隼人, 畠 愛子, 中瀬 泰然, 清水 宏明

    脳循環代謝　32　(1)　75-75　2020年11月

    出版者・発行元： (一社)日本脳循環代謝学会

    ISSN： 0915-9401

    eISSN： 2188-7519

  8. 認知症患者の脳卒中急性期におけるせん妄とその対処法についての検討

    中瀬 泰然, 畠 愛子, 高橋 和孝, 清水 宏明

    Dementia Japan　34　(4)　502-502　2020年10月

    出版者・発行元： (一社)日本認知症学会

    ISSN： 1342-646X

  9. 脳梗塞後認知機能障害に影響する急性期炎症反応の検討

    中瀬 泰然, 師井 淳太, 石川 達哉, 清水 宏明

    Dementia Japan　33　(4)　559-559　2019年10月

    出版者・発行元： (一社)日本認知症学会

    ISSN： 1342-646X

  10. 多様な症状を呈するGerstmann-Straeussler-Scheinker(GSS)病の一家系

    中瀬 泰然, 清水 宏明

    Dementia Japan　32　(3)　455-455　2018年9月

    出版者・発行元： (一社)日本認知症学会

    ISSN： 1342-646X

  11. 遺伝子異常を同定し得た家族性アルツハイマー病の新規家系

    中瀬 泰然, 長田 乾, 佐藤 雄一, 前田 哲也, 池内 健, 宮田 元

    Dementia Japan　31　(4)　605-605　2017年10月

    出版者・発行元： (一社)日本認知症学会

    ISSN： 1342-646X

  12. The Antiplatelet Activity of Direct Oral Anticoagulants in Acute Ischemic Stroke Patients

    Taizen Nakase, Akifumi Suzuki

    CIRCULATION　134　2016年11月

    ISSN： 0009-7322

    eISSN： 1524-4539

  13. The Clinical Features of Poststroke Depression at Acute Phase

    Taizen Nakase, Masahiro Sasaki

    ANNALS OF NEUROLOGY　78　S29-S30　2015年10月

    ISSN： 0364-5134

    eISSN： 1531-8249

  14. Inpatient Stroke Mortality Has Been Declining in Japan: Japanese Stroke Databank

    Daiki Takano, Yumi Fujimaki, Takashi Yamazaki, Taizen Nakase, Tetsuya Maeda, Yuichi Satoh, Ken Nagata, Shotai Kobayashi

    STROKE　46　2015年2月

    ISSN： 0039-2499

    eISSN： 1524-4628

  15. Serum Eiocosapentaenoic Acids Is Protective Against White Matter Lesions

    Daiki Takano, Takashi Yamazaki, Tetsuya Maeda, Yuichi Satoh, Yasuko Ikeda, Taizen Nakase, Ken Nagata

    STROKE　44　(2)　2013年2月

    ISSN： 0039-2499

    eISSN： 1524-4628

  16. Investigating a Pitfall of the ABCD(2) Score of Transient Ischemic Attack Patients

    Taizen Nakase, Masahiro Sasaki

    CEREBROVASCULAR DISEASES　36　21-21　2013年

    ISSN： 1015-9770

    eISSN： 1421-9786

  17. Clinical Features and Subtypes of Minor Ischemic Stroke

    Taizen Nakase, Masahiro Sasaki

    CEREBROVASCULAR DISEASES　36　10-10　2013年

    ISSN： 1015-9770

    eISSN： 1421-9786

  18. 発症25日後に施行した免疫グロブリン大量静注療法が有効であったギラン・バレー症候群の一例

    高野 大樹, 山崎 貴史, 前田 哲也, 佐藤 雄一, 池田 靖子, 中瀬 泰然, 長田 乾, 馬場 正之

    末梢神経　23　(2)　361-361　2012年12月

    出版者・発行元： 日本末梢神経学会

    ISSN： 0917-6772

  19. 脳出血後の血圧日内変動パターンの変化についての24時間血圧計を用いた検討

    中瀬泰然, 亀田知明, 鈴木明文, 長田乾

    脳卒中　34　(4)　215-220 (J-STAGE)　2012年

    DOI： 10.3995/jstroke.34.215 　

    ISSN： 0912-0726

  20. Follow-Up Study of Incidence of Stroke in Brain Dock Examinees

    Masahiro Sasaki, Akifumi Suzuki, Taizen Nakase, Tatsuya Ishikawa

    CEREBROVASCULAR DISEASES　34　129-129　2012年

    ISSN： 1015-9770

  21. 脳卒中の地域住民への啓発活動と脳卒中病院前救護

    鈴木 明文, 中瀬 泰然, 吉岡 正太郎, 佐々木 正弘

    脳卒中　32　(6)　680-683　2010年11月25日

    ISSN： 0912-0726

  22. Mechanism for Dobutamine-Induced Hyperdynamic Transmission to the Relief of Focal Cerebral Ischemia Affected by Vasospasm after Subarachnoid Hemorrhage

    Tatsushi Mutoh, Tatsuya Ishikawa, Shotaro Yoshioka, Taizen Nakase, Akifumi Suzuki

    CIRCULATION　122　(21)　2010年11月

    ISSN： 0009-7322

  23. Extravascular Lung Water and Pulmonary Permeability Dynamics in Patients with Neurogenic Pulmonary Edema after Subarachnoid Hemorrhage

    Tatsushi Mutoh, Tatsuya Ishikawa, Taizen Nakase, Akifumi Suzuki, Nobuyuki Yasui

    NEUROLOGY　74　(9)　A130-A130　2010年3月

    ISSN： 0028-3878

  24. Impact of Early Goal-Directed Hemodynamic Optimization on Clinical Management and Outcome after Subarachnoid Hemorrhage: A Prospective Controlled Study

    Tatsushi Mutoh, Tatsuya Ishikawa, Taizen Nakase, Akifumi Suzuki, Nobuyuki Yasui

    NEUROLOGY　74　(9)　A130-A130　2010年3月

    ISSN： 0028-3878

  25. 進歩する脳梗塞医療

    中瀬 泰然

    秋田県医師会雑誌　60　(2)　60-65　2010年2月

    出版者・発行元： 秋田県医師会

    ISSN： 0286-7656

  26. ガイドライン解説 脳梗塞および一過性脳虚血発作患者の管理に関するガイドライン2008

    中瀬 泰然, 長田 乾

    International review of thrombosis　4　(4)　281-283　2009年12月

    出版者・発行元： メディカルレビュー社

    ISSN： 1880-8549

  27. PERFORMANCE OF THE REFINED FLOTRAC SYSTEM (3RD GENERATION DEVICE) FOR UNCALIBRATED CONTINUOUS CARDIAC OUTPUT MONITORING DURING HYPERDYNAMIC THERAPY OF CEREBRAL VASOSPASM AFTER SUBARACHNOID HEMORRHAGE

    Tatsushi Mutoh, Tatsuya Ishikawa, Taizen Nakase, Akifumi Suzuki, Nobuyuki Yasui

    CRITICAL CARE MEDICINE　37　(12)　A449-A449　2009年12月

    ISSN： 0090-3493

  28. IMPACT OF EARLY GOAL-DIRECTED HEMODYNAMIC OPTIMIZATION ON CLINICAL COURSE AND OUTCOME AFTER SUBARACHNOID HEMORRHAGE

    Tatsushi Mutoh, Tatsuya Ishikawa, Taizen Nakase, Akifumi Suzuki, Nobuyuki Yasui

    CRITICAL CARE MEDICINE　37　(12)　A449-A449　2009年12月

    ISSN： 0090-3493

  29. 脳保護薬 (特集 脳卒中--予防・治療の最前線) -- (診断と治療の最前線)

    中瀬 泰然, 長田 乾

    綜合臨床　58　(2)　266-269　2009年2月

    出版者・発行元： 永井書店

    ISSN： 0371-1900

  30. 延髄梗塞の臨床的検討

    山崎 貴史, 中瀬 泰然, 小倉 直子, 亀田 知明, 前田 哲也, 佐藤 雄一, 高野 大樹, 鈴木 明文, 長田 乾

    脳卒中　29　(4)　502-507　2007年7月25日

    ISSN： 0912-0726

  31. Medullary infarctions in 114 consecutive patients: Spatial and temporal features of MRI findings

    Takashi Yamazaki, Taizen Nakase, Naoko Ogura, Tomoaki Kameda, Yousuke Nakamura, Tetuya Maeda, Yuichi Satoh, Daiki Takano, Akifumi Suzuki, Ken Nagata

    NEUROLOGY　68　(12)　A66-A66　2007年3月

    ISSN： 0028-3878

  32. Ischemia alters the expression of connexins in human brain

    Taizen Nakase, Tetsuya Maeda, Yasuji Yoshida, Ken Nagata

    NEURON GLIA BIOLOGY　2　S157-S158　2007年

    ISSN： 1740-925X

  33. 発症3時間以内のrt-PA静注による血栓溶解療法の転帰と問題点

    鈴木 明文, 師井 淳太, 中瀬 泰然, 吉岡 正太郎, 長田 乾, 佐藤 雄一, 前田 哲也, 澤田 元史, 小林 紀方, 小倉 直子, 泉 学

    脳卒中　28　(4)　661-667　2006年12月25日

    ISSN： 0912-0726

  34. 脳梗塞急性期における炎症マーカーの測定 : 予後および経過の指標としての検討

    中瀬 泰然, 佐藤 美佳, 山崎 貴史, 小倉 直子, 鈴木 明文, 長田 乾

    脳卒中　28　(3)　360-366　2006年9月25日

    ISSN： 0912-0726

  35. Brain imaging in dementias

    Ken Nagata, Tomoaki Kameda, Yosuke Nakamura, Takashi Yamazaki, Naoko Ogura, Taizen Nakase, Tetsuya Maeda, Yuichi Satoh, Mika Sato, Yasushi Kondoh, Kazuhiro Takahashi, Hirohiko Saito

    NEUROPSYCHOBIOLOGY　54　(1)　22-23　2006年

    ISSN： 0302-282X

  36. Hemodyamic pathphysiology in vascular dementia

    Ken Nagata, Tetsitya Maeda, Haruhisa Kato, Yuichi Satoh, Taizen Nakase

    ANNALS OF NEUROLOGY　60　S9-S9　2006年

    ISSN： 0364-5134

  37. 脳梗塞危険因子としてのアンジオテンシン変換酵素遺伝子とアンジオテンシノーゲン遺伝子変異の検索 (第28回東北脳血管障害研究会)

    中瀬 泰然, 長田 乾, 水野 敏樹

    東北脳血管障害研究会学術集会記録集　28　31-36　2005年12月3日

    出版者・発行元： サノフィ・アベンティス仙台オフィス

    ISSN： 1880-9278

  38. 慢性期脳卒中患者における高感度CRP, インターロイキン6の上昇 : スタチン製剤の影響, 病型について

    佐藤 美佳, 長田 乾, 佐藤 雄一, 前田 哲也, 中瀬 泰然

    脳卒中　26　(3)　423-429　2004年9月25日

    ISSN： 0912-0726

  39. 脳血管障害慢性期例における基礎疾患の治療とその問題点

    ヴァンメディカルクリニカルファーマコテラピー　5　(1)　17　1999年

  40. Therapy and problem of risk factors in the chronic phose of stroke patients

    van medical Clinical Pharmacotherapy　5　(1)　17　1999年

  41. A lateralized reduction of NAA in a case of corticobasal degeneration (CBD): Application of proton magnetic resonance spectroscopy (1H-MRS)

    Taizen Nakase, Toshiki Mizuno, Yoshiaki Takanashi, Kenji Nakajima, Yoshio Imahori, Seiichi Furuya, Shoji Naruse

    Brain and Nerve　50　(5)　421-425　1998年5月

    ISSN： 0006-8969

  42. Proton magnetic resonance spectroscopy('H-MRS)によりNAAの低下を認めたcorticobasal degeneration(CBD)の1例

    医学書院脳と神経　50　(5)　421　1998年

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共同研究・競争的資金等の研究課題 10

  1. アストログリオーシスPETを用いた認知症の発症・進行リスク評価システムの開発

    田代 学, 川勝 忍, 古本 祥三, 坂田 宗之, 石井 賢二, 麦倉 俊司, 古川 勝敏, 渡部 浩司, 岡村 信行, 加藤 隆司, 中瀬 泰然, 菊池 昭夫, 小林 良太

    提供機関：Japan Society for the Promotion of Science

    制度名：Grants-in-Aid for Scientific Research

    研究種目：Grant-in-Aid for Scientific Research (A)

    研究機関：Tohoku University

    2025年4月1日 ～ 2029年3月31日

  2. 認知症におけるオートファジー障害の病態解明とPADREによる超早期画像診断法の開発

    瀧 靖之, 古本 祥三, 領家 梨恵, 米田 哲也, 岡村 信行, 舘脇 康子, 関根 弘樹, 中瀬 泰然

    2023年4月1日 ～ 2026年3月31日

  3. 認知症におけるオートファジー障害の病態解明とPADREによる超早期画像診断法の開発

    瀧 靖之, 古本 祥三, 領家 梨恵, 米田 哲也, 岡村 信行, 舘脇 康子, 関根 弘樹, 中瀬 泰然

    2023年4月1日 ～ 2026年3月31日

  4. 慢性脳低灌流を加えた新規認知症モデルの開発と内皮機能障害メカニズムの解明

    中瀬 泰然, 板東 良雄, 清水 宏明

    2021年4月1日 ～ 2024年3月31日

    詳細を見る 詳細を閉じる

    2021年度は新型コロナウイルス蔓延防止対策に伴い移動制限や診療業務の増加に伴い当該研究へのエフォートが不十分な状況であった。共同研究者との動物実験実施ができなかったため、web会議やメールなどにより情報交換を行った。当該動物実験についての動物実験倫理申請を行い、より安全でラットへの負担が少ない手術方法、実験方法を確認し、当該動物実験の承認を得た。 また本研究のテーマである血管内皮機能障害と神経細胞障害との関連について実臨床における状況を確認するべくデータ収集を行った。方法として、アルツハイマー型認知症患者を対象に、過去に2回以上の認知機能検査と頭部MRI検査、血液検査をおこなった症例を後ろ向きに検索した。大脳における慢性炎症、細小動脈障害の惹起因子としてホモシステインに注目した。その結果、1）便秘患者で便秘なし患者に比して血清ホモシステイン値が有意に高いこと、2）便秘患者では同じく便秘なしの患者に比較して大脳白質病変の拡大が有意に速いこと、3）便秘患者では便秘のない患者に対して認知機能悪化速度が有意に速いことを見出した。これらの結果から、便秘により生じたホモシステイン高値と白質病変の拡大および認知機能悪化が併存していることが明らかになった。炎症性血管内皮障害と白質病変との関連を示唆する所見と言え、そのメカニズムを解明するための当該動物実験の重要性を再確認できたといえる。このアルツハイマー型認知症患者を対象とした後ろ向き観察研究の結果については日本認知症学会学術集会で発表するとともに、現在論文投稿中である。

  5. 動脈硬化進展に関与するギャップ結合の病態メカニズ厶についての臨床病理学的解析

    中瀬 泰然

    提供機関：Japan Society for the Promotion of Science

    制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    研究種目：Grant-in-Aid for Scientific Research (C)

    2010年 ～ 2012年

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    頸動脈における動脈硬化巣の不安定化は脳梗塞の原因となる。この動脈硬化巣の不安定化には酸化ストレスによるマクロファージの活性化、血管内皮の脆弱化、動脈硬化巣そのものの血栓化などが関与している。そこで、脳梗塞予防の観点から、動脈硬化巣の安定化に影響を与える要因を検討した。本研究では、細胞間連絡器官であるギャップ結合の構成蛋白であるコネキシン(Cx)の発現に着目し、酸化ストレスを受けている細胞との関連を免疫組織学的に観察した。その結果、サブタイプのCx37は酸化ストレスに関連した動脈硬化巣の安定化に、Cx43は酸化ストレスとは独立した動脈硬化巣の安定化に寄与していることが推測された。

  6. 脳虚血病態に及ぼすアストロサイトギャップ結合機能のヒト剖検脳を用いた検討

    中瀬 泰然

    提供機関：Japan Society for the Promotion of Science

    制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    研究種目：Grant-in-Aid for Young Scientists (B)

    研究機関：Research institute for Brain and Blood Vesseis Akita

    2005年 ～ 2006年

    詳細を見る 詳細を閉じる

    平成17年度に引き続き、平成18年度も対象サンプルに対して、抗ニューロフィラメント(NF70)抗体、抗GFAP抗体、抗ミクログリア(CD68)抗体、抗コネキシン43抗体を用いた免疫組織染色を行った。さらに、各蛋白質発現量の発光強度測定による半定量的解析も行った。関心領域は、対象とした心原性脳塞栓および多発性脳梗塞の脳組織において、正常部位と梗塞巣周辺部位とに無作為に設定した。その結果、コネキシン43蛋白の発現量は、心原性脳塞栓では正常部位と梗塞巣周辺部位とで変化を認めず、多発性脳梗塞の虚血巣周辺部において正常部位と比較して有意な発現量の増加を認めた。また、正常部位においても心原性脳塞栓より多発性脳梗塞でコネキシン43蛋白の発現量が有意に増加していた。さらに、心原性脳塞栓の梗塞巣周辺部位では多発性脳梗塞に比べてミクログリア上でのコネキシン43蛋白発現量が増加していた。結論として、虚血ストレスに対してはアストロサイトとミクログリアともにコネキシン43蛋白の発現量を増加させ、神経保護的に作用していると考えられた。特に慢性期脳虚血巣においては正常部位でのアストロサイトもその発現量を増加させていたことから、アストロサイトのギャップ結合は虚血耐性に対しても重要な役割を果たしていると考えられた。 以上の結果は国際学術誌"GLIA"にて報告した。また、ヨーロッパ神経学会年次総会(FENS、ウィーン)にてポスター発表を行った。

  7. 自然発症高血圧ラットのCD36の神経系での作用の解析 競争的資金

  8. 自然発症高脂血症マウスに関する病態解析 競争的資金

  9. Analysis of the function of CD36 in the nourous system of Spontaneously hypertensive rat 競争的資金

  10. Pathological study of Spontaneously hyperlipidemic mouse 競争的資金

︎全件表示 ︎最初の5件までを表示