東北大学研究者紹介

研究者詳細

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エンドウ　ヒデノリ

遠藤　英徳

Hidenori Endo

所属

大学院医学系研究科　医科学専攻　神経・感覚器病態学講座（神経外科学分野）

職名

教授

学位

医博第2408号（東北大学）

researchmap

https://researchmap.jp/hideendo

J-GLOBAL ID

201901018444977010

e-Rad 研究者番号

40723458

ORCID

https://orcid.org/0000-0003-1472-6032

経歴 8

2023年4月～継続中

東北大学大学院医学系研究科神経外科学分野　教授
2022年1月～継続中

一般財団法人広南会広南病院　副院長兼脳神経外科部長
2021年4月～継続中

東北大学大学院医学系研究科連携講座先進脳血管外科学講座　教授
2021年1月～継続中

一般財団法人広南会広南病院　脳神経外科　部長
2020年1月～ 2020年12月

国立病院機構仙台医療センター　脳神経外科　医長
2018年5月～ 2019年12月

東北大学　脳神経外科　講師
2017年7月～ 2018年4月

東北大学　脳神経外科　助教
2015年6月～ 2017年6月

一般財団法人広南会広南病院　脳神経外科　部長

︎全件表示 ︎最初の5件までを表示

学歴 1

東北大学　医学部

1995年4月～ 2001年3月

委員歴 9

日本脳循環代謝学会　理事

2023年11月～継続中
日本脳神経外科学会　理事

2023年10月～継続中
脳神経外科手術と機器学会　理事

～継続中
公益財団法人宮城県対脳卒中協会　会長

～継続中
SAHスパズムシンポジウム　世話人

～継続中
日本脳神経血管内治療学会　理事

～継続中
日本脳神経外科コングレス　理事

～継続中
日本脳卒中学会　理事

～継続中
日本脳卒中の外科学会　理事

～継続中

︎全件表示 ︎最初の5件までを表示

研究キーワード 5

バイパス手術
もやもや病
脳動静脈奇形
脳動脈瘤
脳血管障害

研究分野 1

ライフサイエンス / 脳神経外科学 /

論文 317

Postoperative reduction of anti‐seizure medication is associated with cognitive improvement in seizure‐free patients after anterior temporal lobectomy

Kazushi Ukishiro, Shin‐ichiro Osawa, Maimi Ogawa, Makoto Ishida, Takafumi Kubota, Kazutoshi Konomatsu, Hidenori Endo, Kazutaka Jin

Epilepsia　2026年7月20日

DOI： 10.1002/epi.70395 　
Multiscale modeling of blood circulation with cerebral autoregulation and network pathway analysis for hemodynamic redistribution in the vascular network with anatomical variations and stenosis conditions

Jiawei Liu, Atsushi Kanoke, Hidenori Endo, Kuniyasu Niizuma, Hiroshi Suito

PLOS Computational Biology　22　(5)　e1013853-e1013853　2026年5月18日
出版者・発行元： Public Library of Science (PLoS)
DOI： 10.1371/journal.pcbi.1013853 　

eISSN：1553-7358

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Cerebral hemodynamics is fundamentally regulated through the Circle of Willis (CoW), which redistribute flow via communicating arteries to stabilize perfusion under anatomical variations and vascular stenosis. In this study, a multiscale circulation model was developed by coupling a multiscale systemic hemodynamic framework with cerebral arterial network reconstructed from medical imaging. The model integrates a cerebral autoregulation mechanism (CAM) and enables quantitative simulation of flow redistribution across the CoW under normal, anatomically varied, and pathologically narrowing (stenosis) conditions. Baseline simulations at normal states reproduced physiological flow distributions in which the communicating arteries remained nearly inactive, showing negligible across-flow and agreement with clinical measurements, while two anatomical variations revealed distinct collateral activation patterns: the anterior communicating artery (ACoA) acted as the earliest and most sensitive functional collateral pathway, whereas the posterior communicating arteries (PCoAs) exhibited structure-dependent engagement. Progressive stenosis modeling further demonstrated the transition from a complete CoW to a fetal-type posterior cerebral artery (PCA) configuration, with early ACoA flow reversal followed by the ipsilateral PCoA activation, in agreement with experimental and transcranial Doppler observations. We further present a path-based quantitative analysis of source-to-sink flow contributions to quantitatively illustrates how the cerebral vascular network dynamically reconfigures collateral pathways in response to structural changes. Overall, the proposed framework provides a physiologically interpretable and image-informed tool for investigating cerebral flow regulations through the functional collaterals within the CoW, offering potential for clinical applications in the diagnosis, prognosis, and treatment planning of cerebrovascular diseases.
Dual impact of flow diverters on ischemic and hemorrhagic outcomes in vertebral artery dissecting aneurysms presenting with ischemia

Yuto Shingai, Hiroyuki Sakata, Shunsuke Omodaka, Tomohisa Ishida, Ryosuke Tashiro, Yoshimichi Sato, Hidenori Endo

Frontiers in Neurology　17　2026年5月8日
出版者・発行元： Frontiers Media SA
DOI： 10.3389/fneur.2026.1815552 　

eISSN：1664-2295

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Introduction Intracranial vertebral artery dissecting aneurysms (VADA) may manifest as ischemic stroke. Although some individuals stabilize with conservative management, aneurysmal enlargement and recurrent embolic events may still occur, especially in partially thrombosed lesions. The role of flow diversion (FD) in ischemia-onset VADA remains unclear. This study reports the first focused experience evaluating FD in VADA with ischemic onset. Methods Among 119 FD procedures performed between 2022 and 2025, four male individuals were treated for ischemia-onset VADA. All lesions were in the V4 segment, and three showed partial thrombosis. FD was selected for aneurysmal enlargement (four individuals) or recurrent infarction (two individuals). Dual antiplatelet therapy was started at least 7 days before the procedure. Results FD placement was technically successful in all cases, with no complications. Six-month angiography showed O’Kelly–Marotta grade C occlusion in all lesions, indicating effective flow remodeling. No individuals experienced recurrent cerebral infarction or aneurysmal rupture. Conclusion Flow diversion may be a feasible treatment option in selected cases of ischemia-onset VADA. It may reduce the risk of recurrent embolic events and aneurysmal rupture.
An Admission-Only Prognostic Model for Early Outcome Prediction After Aneurysmal Subarachnoid Haemorrhage: Development and Temporal Validation

Atsushi Nakayashiki, Kunihiko Umezawa, Yasuo Nishijima, Ryutaro Suzuki, Michiko Yokosawa, Hidenori Endo

2026年4月30日

DOI： 10.64898/2026.04.28.26352003 　
Intraoperative hemispheric circulation time as a potential predictor of aneurysm occlusion after flow diverter treatment in large internal carotid artery aneurysm

Yoshimichi Sato, Hiroyuki Sakata, Kenshi Sano, Atsushi Kanoke, Shunsuke Omodaka, Hidenori Endo

Neurosurgical Review　49　(1)　2026年4月18日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1007/s10143-026-04285-y 　

eISSN：1437-2320
Association between Pretreatment Circumferential Wall Enhancement and Retreatment Rate in Endovascularly Treated Internal Carotid - Posterior Communicating Artery Aneurysms. 国際誌

Yun-Ju Shih, Hiroyuki Sakata, Shunsuke Omodaka, Yoshimichi Sato, Kenshi Sano, Hidenori Endo

World neurosurgery　124939-124939　2026年3月27日

DOI： 10.1016/j.wneu.2026.124939 　

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OBJECTIVE: Internal carotid-posterior communicating artery (IC-PC) aneurysms have a high recurrence rate after endovascular treatment. Pretreatment MRI vessel wall imaging (VWI) may predict recurrence through aneurysm wall enhancement (AWE) patterns; however, its role in IC-PC aneurysms remains unclear. This study investigated the association between pretreatment VWI findings and retreatment risk in patients with IC-PC aneurysms. METHODS: This single-center retrospective cohort study included 173 patients with IC-PC aneurysms among 1145 intracranial aneurysms (IAs) treated endovascularly from 2016 to 2021. Patients without 1-year follow-up or pretreatment VWI were excluded. The baseline clinical, angiographic, and VWI characteristics were analyzed. AWE was classified into circumferential aneurysm wall enhancement (CAWE), focal enhancement, or negative. The primary outcome was the identification of risk factors for retreatment, as assessed using multivariate logistic regression. RESULTS: Retreatment was more frequent in IC-PC aneurysms than in all IAs (19% vs. 10%, p<0.001). Among IC-PC aneurysms, 141 patients required no retreatment (effective treatment group), and 32 required retreatment. Factors that were significantly different between the effective treatment and retreatment groups included initial presentation (p=0.009), maximum aneurysm diameter (p<0.001), neck width (p<0.001), posterior communicating artery type (p=0.019), and VWI enhancement pattern (p<0.001). Multivariable analysis identified CAWE as the only independent predictor (odds ratio, 28.1; 95% confidence interval, 8.15-90.3; p<0.001). CAWE was observed in 72% of retreatment cases compared with 8.5% of effective treatment cases. CONCLUSIONS: Pretreatment CAWE on VWI is a strong independent predictor of retreatment in IC-PC aneurysms after endovascular treatment.
Calcified nodules in the cervical carotid artery

Yoshihiko Morisue, Hiroki Uchida, Fumiyoshi Fujishima, Hirofumi Watanabe, Atsushi Kanoke, Hiroyuki Sakata, Hidenori Endo

Surgical Neurology International　17　82-82　2026年2月13日
出版者・発行元： Scientific Scholar
DOI： 10.25259/sni_715_2025 　

ISSN：2229-5097

eISSN：2152-7806

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Background: Calcified nodules (CNs) are a distinct morphological subtype of calcified plaques that cause acute coronary events. However, their clinical relevance in carotid artery disease remains poorly understood. Case Description: We report two cases of symptomatic carotid artery stenosis caused by CNs, both successfully treated with carotid endarterectomy (CEA). In both cases, computed tomography angiography (CTA) revealed severely stenotic lesions with bulky calcified plaques protruding into the vascular lumen. Plaque imaging with magnetic resonance imaging and carotid ultrasonography suggested the presence of calcified components. Surgical excision confirmed the diagnosis of CNs through pathological evaluation. Both patients had favorable outcomes with no neurological deficits on discharge. Notably, CNs are rarely reported in the context of carotid artery disease, and preoperative diagnosis remains challenging due to the lack of established imaging criteria. CTA may be a useful non-invasive tool for identifying CNs, as shown in coronary artery studies. Conclusion: These cases demonstrate that CNs can cause severe carotid stenosis requiring CEA. CTA may aid in the preoperative identification of CNs, and when CNs are identified on CTA, CEA should be the preferred treatment over carotid artery stenting. Further studies are warranted to clarify the diagnostic criteria and treatment strategies for CNs in carotid disease.
Calcified nodules in the cervical carotid artery

Yoshihiko Morisue, Hiroki Uchida, Fumiyoshi Fujishima, Hirofumi Watanabe, Atsushi Kanoke, Hiroyuki Sakata, Hidenori Endo

Surgical Neurology International　17　82-82　2026年2月13日
出版者・発行元： Scientific Scholar
DOI： 10.25259/sni_715_2025 　

ISSN：2229-5097

eISSN：2152-7806

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Background: Calcified nodules (CNs) are a distinct morphological subtype of calcified plaques that cause acute coronary events. However, their clinical relevance in carotid artery disease remains poorly understood. Case Description: We report two cases of symptomatic carotid artery stenosis caused by CNs, both successfully treated with carotid endarterectomy (CEA). In both cases, computed tomography angiography (CTA) revealed severely stenotic lesions with bulky calcified plaques protruding into the vascular lumen. Plaque imaging with magnetic resonance imaging and carotid ultrasonography suggested the presence of calcified components. Surgical excision confirmed the diagnosis of CNs through pathological evaluation. Both patients had favorable outcomes with no neurological deficits on discharge. Notably, CNs are rarely reported in the context of carotid artery disease, and preoperative diagnosis remains challenging due to the lack of established imaging criteria. CTA may be a useful non-invasive tool for identifying CNs, as shown in coronary artery studies. Conclusion: These cases demonstrate that CNs can cause severe carotid stenosis requiring CEA. CTA may aid in the preoperative identification of CNs, and when CNs are identified on CTA, CEA should be the preferred treatment over carotid artery stenting. Further studies are warranted to clarify the diagnostic criteria and treatment strategies for CNs in carotid disease.
Minimally invasive treatment strategy combining a partial resection with cyst aspiration and subsequent Gamma Knife radiosurgery for cystic hypoglossal neurinoma in an older adult: illustrative case. 国際誌

Keigo Mizuno, Ryosuke Tashiro, Shunsuke Omodaka, Tomohisa Ishida, Ryo Kusaka, Rikuto Ito, Hiroyuki Sakata, Hidefumi Jokura, Hidenori Endo

Journal of neurosurgery. Case lessons　11　(6)　2026年2月9日

DOI： 10.3171/CASE25821 　

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BACKGROUND: Hypoglossal neurinomas are rare tumors that pose management challenges, particularly when they contain cystic components. While total removal remains the standard treatment, resection can be excessively invasive for older adults. This report describes a case of cystic hypoglossal neurinoma successfully treated through a partial resection with cyst aspiration followed by Gamma Knife radiosurgery (GKRS). OBSERVATIONS: A male aged 81 years presented with progressive dysarthria and dysphagia secondary to left hypoglossal nerve palsy. MRI revealed a cystic lesion compressing the medulla and a solid component within the left hypoglossal canal. Cyst aspiration was performed to alleviate potentially life-threatening lower cranial nerve palsy, followed by GKRS. At 21 months, marked cyst shrinkage was observed after a transient post-GKRS expansion, with no further interventions required. LESSONS: A treatment strategy combining cyst aspiration and GKRS was useful for managing cystic hypoglossal neurinoma in an older adult. Minimally invasive management should be considered for older adults with comorbidities who are at increased risk for postoperative complications. https://thejns.org/doi/10.3171/CASE25821.
Developing a predictive model for rapid stroke diagnosis via blood using mid-infrared spectroscopy. 国際誌

Saiko Kino, Tomohisa Ishida, Kuniyasu Niizuma, Masayuki Kanamori, Kenichi Sato, Naoki Shida, Hidenori Endo, Yuji Matsuura

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy　346　126883-126883　2026年2月5日

DOI： 10.1016/j.saa.2025.126883 　

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BACKGROUND: The diagnosis of stroke requires rapid and objective methods for timely therapeutic intervention. However, the high incidence of stroke and limited healthcare resources, including imaging modalities, underscores the need for rapid diagnostic tools. Mid-infrared (MIR) spectroscopy is a comprehensive blood analysis method characterized by simplicity, speed, and cost-effectiveness. We analyzed plasma using MIR spectroscopy to evaluate its diagnostic value in differentiating patients with stroke from non-stroke individuals, identifying stroke subtypes, and predicting the volume of affected brain lesions. METHODS: Peripheral blood plasma from 324 individuals (160 patients with stroke, 3 with transient ischemic attack, 8 with stroke mimics, and 153 controls) was analyzed using attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy. Partial least squares analysis of absorbance at each wavenumber was performed, and diagnostic accuracy was assessed by cross-validation. RESULTS: The model distinguished patients with stroke from non-stroke individuals with 87.9 % accuracy and an area under the curve of 0.97. Among patients with stroke, ischemic stroke was identified with 73 % classification accuracy, outperforming hemorrhagic stroke. The spectral characteristics suggested structural changes in plasma proteins, indicating protein aggregation, along with marked increase in lipid concentrations. Lesion volume prediction yielded correlation coefficients of 0.61 and 0.34 in intracerebral hemorrhage and ischemic stroke, respectively. CONCLUSIONS: ATR-FTIR spectroscopy is a promising and minimally invasive approach for rapid stroke detection.
Long-term intelligence after high-dose radiotherapy to the primary site versus chemotherapy and whole-ventricle radiotherapy in patients with germinoma.

Masayuki Kanamori, Yumi Sugawara, Yoshiteru Shimoda, Osamu Iizuka, Yoshinari Osada, Shota Yamashita, Ichiyo Shibahara, Rei Umezawa, Naoko Mori, Ryuta Saito, Yukihiko Sonoda, Toshihiro Kumabe, Keiichi Jingu, Shunji Mugikura, Kyoko Suzuki, Hidenori Endo

International journal of clinical oncology　2026年1月30日

DOI： 10.1007/s10147-026-02976-6 　

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BACKGROUND: Until 1995, patients with newly diagnosed germinoma received 40-60 Gy of radiation to the primary site with or without chemotherapy (regimen A). After 2000, treatment shifted to chemotherapy followed by 24 Gy of whole-ventricle radiation therapy (WVRT) (regimen B). This study compares long-term intelligence outcomes between the two treatment regimens. METHODS: This retrospective analysis included 151 patients diagnosed with germinoma between 1983 and 2021. Intelligence was assessed using the Wechsler Adult Intelligence Scale (revised or 3rd edition) and the Wechsler Intelligence Scale for Children (3rd edition). Patient backgrounds were also collected. RESULTS: A total of 55 and 69 patients were treated with regimens A and B, respectively. The number of patients who underwent at least one longitudinal neurocognitive assessment was 35 and 29 for regimen A and 53 and 22 for regimen B, respectively. The median interval from initial treatment to the last neurocognitive assessment was 120 months. In the longitudinal intelligence assessments, the median intervals were 58 months from treatment to the first evaluation and 83 months from the first to the final assessment. Full-Scale Intelligence Quotient (FSIQ) scores declined in regimen A but were maintained in regimen B according to analysis of covariates and generalized linear mixed model analysis. CONCLUSION: Chemotherapy followed by 24 Gy of WVRT appears to be associated with a smaller decline in FSIQ over a long-term follow-up.
The AMORE score for predicting the 5-year risk of hemorrhagic stroke in asymptomatic moyamoya disease. 国際誌

Tomohito Hishikawa, Satoshi Murai, Yoichi M Ito, Takeshi Funaki, Miki Fujimura, Eika Hamano, Hiroharu Kataoka, Jun C Takahashi, Hidenori Endo, Motoki Inaji, Tadashi Nariai, Kaori Honjo, Toshiaki Osato, Satoru Miyawaki, Nobuhito Saito, Makoto Isozaki, Kenichiro Kikuta, Toshio Machida, Mitsuhito Mase, Koji Yamaguchi, Takakazu Kawamata, Norihiro Sato, Shusuke Yamamoto, Emiko Hori, Daina Kashiwazaki, Susumu Miyamoto, Satoshi Kuroda

Cerebrovascular diseases (Basel, Switzerland)　1-9　2026年1月30日

DOI： 10.1159/000550273 　

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INTRODUCTION: The aim of this study was to establish the score for predicting the 5-year risk of hemorrhagic stroke in patients with asymptomatic moyamoya disease (MMD) using the Asymptomatic Moyamoya Registry (AMORE) data and to evaluate its reproducibility. METHODS: The AMORE study was a prospective cohort study that recruited participants from 18 centers in Japan. A total of 103 patients completed the 5-year follow-up and of these, 6 patients experienced hemorrhagic stroke. According to the results of multivariate analysis, we selected age ≥46 years, Grade -2 choroidal anastomosis, and microbleeds as variables in the prediction model. The cumulative rates of hemorrhagic stroke were estimated per hemisphere using the Kaplan-Meier method. Nonparametric bias-corrected confidence intervals based on the Bootstrap sample were calculated to assess the reproducibility of the 5-year risk of hemorrhagic stroke. RESULTS: We created the AMORE score (0-3 points) to estimate the 5-year risk of hemorrhage with 1 point for each of age ≥46 years, Grade -2 choroidal anastomosis, and microbleeds. The AMORE score was applied to a total of 135 MMD hemispheres. The 5-year risk of hemorrhagic stroke per hemisphere was 1.8%, 1.6%, 15.4%, and 50.0% for AMORE scores of 0, 1, 2, and 3, respectively. The cumulative rate of hemorrhagic stroke for AMORE score 3 was significantly higher than for AMORE score 0 (Hazard ratio (HR), 38.7; 95% confidence interval (CI), 3.45-433; p = 0.003) and score 1 (HR, 41.8; 95% CI, 3.74-468; p = 0.002). The corresponding 90% CIs were 0% to 5.6%, 0% to 5.2%, 0% to 38.5%, and 0% to 100%, and the corresponding 80% CIs were 0% to 4.7%, 0% to 4.5%, 5.9% to 33.3%, and 23% to 100% for AMORE scores 0, 1, 2, and 3, respectively. CONCLUSION: The 5-year risk of hemorrhagic stroke in patients with asymptomatic MMD can be adequately estimated using the AMORE score.
Whole-Brain Dynamic Causal Tractography Atlas of Auditory and Visual Speech Networks Derived From Intracranial Neurophysiologic Data

Ryuzaburo Kochi, Aya Kanno, Hiroshi Uda, Keisuke Hatano, Hidenori Endo, Michael Cools, Robert Rothermel, Aimee F. Luat, Eishi Asano

Neurology　2026年1月27日

DOI： 10.1212/WNL.0000000000214448 　
Feasibility of long-read nanopore sequencing for methylation-based classification of posterior fossa ependymomas

Seiji Yamada, Tetsuya Takimoto, Yoshiteru Shimoda, Fumiharu Ohka, Masayuki Kanamori, Kennosuke Karube, Hidenori Endo, Ryuta Saito, Hideyuki Saya, Eiji Sugihara

Brain Tumor Pathology　2026年1月21日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1007/s10014-025-00530-2 　

ISSN：1433-7398

eISSN：1861-387X
Optimal strategy for mechanical thrombectomy based on the preoperative imaging features of the thrombus. 国際誌

Hiroyuki Sakata, Masayuki Ezura, Ryosuke Tashiro, Shunsuke Omodaka, Kenichi Sato, Kuniyasu Niizuma, Hidenori Endo

Clinical neurology and neurosurgery　263　109322-109322　2026年1月18日

DOI： 10.1016/j.clineuro.2026.109322 　

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OBJECTIVE: Successful recanalization is not achieved in approximately 20 % of stroke patients who underwent mechanical thrombectomy, possibly due to the characteristics of the underlying thrombus. This study aimed to identify the most appropriate thrombectomy strategy based on the preoperative imaging features of the thrombus. METHODS: We retrospectively evaluated the data of 70 patients who underwent mechanical thrombectomy. Thrombus density was assessed using non-contrast computed tomography (ΔCT values) and CT angiography (thrombus permeability). Difficult-to-retrieve thrombi were categorized based on the cutoff values (ΔCT <10 Hounsfield units and/or thrombus permeability <9 Hounsfield units). Favorable outcomes (modified Rankin scale score of 0-2) and successful recanalization (Thrombolysis in Cerebral Infarction grade 2b or 3) were evaluated. We also analyzed the interaction between thrombus imaging features and thrombectomy strategy (stent retriever (SR) alone vs. combined strategy) and its effect on recanalization. RESULTS: Patients with favorable outcomes and successful recanalization had statistically higher ΔCT values and thrombus permeability. Multiple logistic analyses identified difficult-to-retrieve thrombi as independently associated with fewer favorable outcome (odds ratio: 0.12 [0.03-0.36], p < 0.001). The combined strategy demonstrated significantly greater effectiveness in achieving successful recanalization for difficult-to-retrieve thrombi compared with the SR-alone strategy (84.2 % vs. 50 %, odds ratio: 5.33, 95 % CI: 1.14-24.90, p = 0.038). However, normal thrombi demonstrated comparable responses with both strategies (92.3 % vs. 100 %, p = 0.394). CONCLUSION: Given its procedural simplicity and cost-effectiveness, the SR-alone strategy may be effective for normal thrombi, whereas the combined strategy may be preferable for difficult-to-retrieve thrombi.
両側性の側頭葉言語機能局在を証明し、機能温存目的に遠隔部位追加切除を行った右後頭葉てんかんの一例

二宮敦彦, 大沢伸一郎, 鈴木匡子, 柿沼一雄, 浮城一司, 鈴木博義, 中里信和, 遠藤英徳

てんかん研究　43　(3)　637-638　2026年1月
出版者・発行元： (一社)日本てんかん学会
ISSN：0912-0890

eISSN：1347-5509
Seizure-Induced Transient Early Venous Visualization on Angiography in Glioblastoma: A Case Report

Daiki Aburakawa, Atsushi Kanoke, Hiroki Uchida, Hiroyuki Sakata, Hidenori Endo

Journal of Neuroendovascular Therapy　20　(1)　n/a-n/a　2026年
出版者・発行元： The Japanese Society for Neuroendovascular Therapy
DOI： 10.5797/jnet.cr.2025-0164 　

ISSN：1882-4072

eISSN：2186-2494
[Paradigm Shift in Intracranial Aneurysm Management: Clinical Application of Flow Diverters in Japan].

Hiroyuki Sakata, Hidenori Endo

No shinkei geka. Neurological surgery　54　(1)　63-71　2026年1月

DOI： 10.11477/mf.030126030540010063 　

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Endovascular treatment of large, wide-necked intracranial aneurysms has been challenged by high recurrence rates following coil embolization. Flow diverters, designed to redirect blood flow away from the aneurysm sac and promote thrombosis and vessel wall reconstruction, have transformed therapeutic strategies. These devices, characterized by high mesh density compared to conventional stents, have become cornerstones in aneurysm management. Since the approval of the Pipeline device in 2008, multiple flow diverters have been developed worldwide; clinical use in Japan began in 2015, with expanded indications after 2020. Currently, Pipeline Flex with Shield Technology, FRED X, and Surpass Evolve are available domestically, each with distinct structural features, deployment characteristics, and antithrombotic properties. This article provides an overview of their differences, focusing on device selection, deployment techniques, and clinical applicability. By integrating device-specific considerations with structured preoperative planning, flow-diverter therapy offers a paradigm shift in treating complex aneurysms, thereby expanding options for cases resistant to conventional interventions.
Clinical profile of idiopathic normal pressure hydrocephalus with reduced myocardial sympathetic nerve function

Shiho Matsubara, Shigenori Kanno, Toru Baba, Yoshiyuki Nishio, Chifumi Iseki, Nobuko Kawakami, Kazuo Kakinuma, Hayato Odagiri, Shoko Ota, Keiko Endo, Kentaro Takanami, Shin-ichiro Osawa, Tomohiro Kawaguchi, Hidenori Endo, Kyoko Suzuki

Parkinsonism & Related Disorders　108213-108213　2026年1月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.parkreldis.2026.108213 　

ISSN：1353-8020
Early Postoperative Venous Thromboembolism After Tumor Resection for Diffuse Gliomas: Diagnosis and Implications for Preventing Symptomatic Venous Thromboembolism

Yoshinari Osada, Masayuki Kanamori, Shota Yamashita, Yoshiteru Shimoda, Hidenori Endo

World Neurosurgery　2026年1月

DOI： 10.1016/j.wneu.2025.124732 　
High-intensity Bilateral Hypothalamus on T2-weighted Magnetic Resonance Imaging: A Unique Radiographical Finding of Chordoid Glioma-Report of 3 Cases

Kaoru SHOJI, Tomohiro KAWAGUCHI, Tomohisa ISHIDA, Atsushi KANOKE, Yoshiteru SHIMODA, Masayuki KANAMORI, Hirofumi WATANABE, Hiroko OGATA, Fumiyoshi FUJISHIMA, Hidenori ENDO

NMC Case Report Journal　12　439-444　2025年12月31日
出版者・発行元： Japan Neurosurgical Society
DOI： 10.2176/jns-nmc.2024-0337 　

eISSN：2188-4226
Internal and External Validation of Comprehensive High-Frequency Activity Biomarkers for Epilepsy Surgery. 国際誌

Keisuke Hatano, Naoto Kuroda, Hiroshi Uda, Kazuki Sakakura, Michael J Cools, Aimee F Luat, Shin-Ichiro Osawa, Hitoshi Nemoto, Kazushi Ukishiro, Hidenori Endo, Nobukazu Nakasato, Yutaro Takayama, Keiya Iijima, Masaki Iwasaki, Eishi Asano

medRxiv : the preprint server for health sciences　2025年12月19日

DOI： 10.64898/2025.12.17.25342490 　

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Although epilepsy surgery studies have proposed intracranial EEG-derived biomarkers for localizing seizure onset and anticipating postoperative outcomes, evaluation has often been limited to derivation cohorts using internal cross-validation. An influential notion holds that neurons distributed within the seizure onset zone (SOZ) frequently generate high-frequency activity (HFA) and that resection of such sites is associated with favorable postoperative seizure control. However, the extent to which these prediction models generalize to independent patient populations-and across diverse underlying etiologies-has remained largely untested. In this international, multi-center study of drug-resistant focal epilepsy, we retrospectively quantified HFA occurrence rates together with a comprehensive set of morphological features and integrated these metrics into predictive models for SOZ localization and postoperative seizure outcome. We then assessed model performance in fully independent datasets-a temporal external cohort and two geographical external cohorts-each entirely separate from the derivation cohort. In total, 5,142,891 HFA events observed across 22,939 electrodes from 233 patients were analyzed. Among the model inputs, HFA rate, spectral entropy, and power emerged as the most influential features for accurate SOZ classification. The model reliably identified clinician-defined SOZ sites across centers, achieving areas under the curve (AUCs) of up to 0.85 in the derivation cohort using 10-fold cross-validation, up to 0.86 in the temporal external cohort, and up to 0.75 in the geographical external cohorts. Within the derivation cohort, the model predicted postoperative seizure freedom with an AUC of up to 0.70. In contrast, postoperative seizure outcomes could not be predicted reliably across the external cohorts. Specifically, among external-cohort patients with MRI non-lesional epilepsy, postoperative seizure freedom was predicted with an AUC of up to 0.73, whereas performance declined to 0.46 or below among patients with encephalomalacia, an etiology characterized by chronic parenchymal damage and marked neuronal loss. Together, integration of HFA occurrence rates with morphological features yields an SOZ-localization biomarker with cross-center generalizability, whereas postoperative outcome prediction remains highly dependent on underlying etiology. Notably, a surgical strategy that prioritizes resection of HFA-involved areas does not appear to be applicable to patients with encephalomalacia and may be ineffective or even counterproductive in this population. A total of 97.86 GB of iEEG data are publicly available to facilitate external validation by the epilepsy surgery research community and the development of improved biomarkers for epileptogenic zone localization.
Functional Assessment of Cerebrovascular Dynamics Through Continuous Intracranial Arterial Pressure Waveform Analysis. 国際誌

Ryuzaburo Kochi, Eishi Asano, Yoshiteru Shimoda, Atsushi Kanoke, Shunsuke Omodaka, Hiroyuki Sakata, Kanako Sato, Yasuhiro Suzuki, Yasushi Matsumoto, Kuniyasu Niizuma, Hidenori Endo

World neurosurgery　207　124746-124746　2025年12月18日

DOI： 10.1016/j.wneu.2025.124746 　
Multifactorial Biomarkers for "Talk and Deteriorate" after Head Trauma Identified Using Machine Learning.

Youhei Takeuchi, Shinya Sonobe, Kuniyasu Niizuma, Arata Nagai, Ayumi Narisawa, Atsuhiro Nakagawa, Motonobu Kameyama, Hiroshi Karibe, Hidenori Endo, Teiji Tominaga

Neurologia medico-chirurgica　65　(12)　568-575　2025年12月15日

DOI： 10.2176/jns-nmc.2025-0166 　

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Talk and Deteriorate refers to a clinical course where a patient is able to speak immediately after a traumatic brain injury but subsequently deteriorates in consciousness. Talk and Deteriorate outcomes are poor, and reliable prediction may help improve them. We searched for multifactorial biomarkers-combinations of multiple risk factors-assuming they would predict Talk and Deteriorate more reliably than single factors. A total of 680 consecutive patients aged ≥16 years with intracranial traumatic lesions and a Glasgow Coma Scale of 13-15 upon admission were included. Information on 27 factors at admission and whether Talk and Deteriorate developed was collected. The correlation between Talk and Deteriorate incidence and each factor was evaluated using univariate analysis. Multifactorial biomarkers associated with a high Talk and Deteriorate incidence were identified using a brute force method combined with clustering based on combinations of factors and various thresholds for each. Among the 680 patients, 89 (13.1%) developed Talk and Deteriorate. A total of 94 multifactorial biomarkers with a Talk and Deteriorate incidence rate of ≥50.0% were identified. These multifactorial biomarkers, which included factors previously suspected to be related to Talk and Deteriorate, were associated with a higher Talk and Deteriorate incidence than each factor alone. Thus, this study indicates that predicting Talk and Deteriorate is more reliable when based on multifactorial biomarkers than on single factors. Factors not previously reported as independent biomarkers contributed as components of multifactorial biomarkers, while previously reported factors played more important roles within them. Thus, this study revealed multifactorial contributions of factors related to Talk and Deteriorate. Future studies focusing on these biomarkers, incorporating pathophysiologic insights, will improve Talk and Deteriorate outcomes.
Anastomotic pseudoaneurysm presenting 50 years after common carotid artery–subclavian artery bypass: illustrative case

Mayuko Otomo, Tomoo Inoue, Nobuo Noshita, Toshie Takahashi, Jun Kikuchi, Hidenori Endo

Journal of Neurosurgery: Case Lessons　2025年12月15日

DOI： 10.3171/CASE25704 　
Preoperative assessment of perforating arteries around amygdala glioblastoma using intra-arterial CT angiography with ultra-high-resolution CT and MR tractography: a case report. 国際誌

Gaku Inoue, Masayuki Kanamori, Shin-Ichiro Osawa, Yoshiteru Shimoda, Kazuki Shimada, Shingo Kayano, Yoshinari Osada, Shota Yamashita, Shunji Mugikura, Hidenori Endo

Acta neurochirurgica　167　(1)　320-320　2025年12月11日

DOI： 10.1007/s00701-025-06741-y 　

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Preservation of the perforating arteries (PAs) supplying the pyramidal tract (PT-PAs) is essential during glioblastoma resection. A 60-year-old man presented with sensory aphasia caused by a left medial temporal glioblastoma. To determine the surgical indication and strategy, we assessed the tumor's location and its relationship with the PT-PAs using intra-arterial computed tomography (CT) angiography combined with ultra-high-resolution CT (UHR-IA-CTA), gadolinium-enhanced T1-weighted magnetic resonance imaging, and tractography. Imaging revealed an amygdala glioblastoma without the involvement of PT-PAs. Total tumor resection was achieved without neurological deficits. This case highlights how integrating UHR-IA-CTA can guide surgical planning and enable safe, complete glioblastoma resection.
Long-term clinical control in acromegaly patients with postoperative discordant nadir growth hormone during oral glucose tolerance test and insulin-like growth factor 1 levels: a retrospective observational study and literature review

Tomohisa Ishida, Tomohiro Kawaguchi, Yoshikazu Ogawa, Hidenori Endo

Langenbeck's Archives of Surgery　2025年12月10日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1007/s00423-025-03951-x 　

eISSN：1435-2451
Improvement of Functional Brain Mapping Through Selective Anesthesia by the Combination of Super-Selective Infusion and Customized Neurocognitive Tests. 国際誌

Shin-Ichiro Osawa, Kyoko Suzuki, Kazuo Kakinuma, Hana Kikuchi, Nobukazu Nakasato, Hidenori Endo

World neurosurgery　204　124482-124482　2025年12月

DOI： 10.1016/j.wneu.2025.124482 　
Stratified assessment of clazosentan efficacy following subarachnoid hemorrhage: A multi-center cohort study. 国際誌

Hiroyuki Sakata, Hiroki Uchida, Atsushi Kanoke, Shunsuke Omodaka, Ryosuke Tashiro, Yoshimichi Sato, Naoto Kimura, Masahiro Yoshida, Kenichi Sato, Kuniyasu Niizuma, Hirohito Metoki, Hidenori Endo

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism　271678X251399068　2025年11月21日

DOI： 10.1177/0271678X251399068 　

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There are conflicting results regarding the efficacy of clazosentan, a selective endothelin A receptor antagonist, on cerebral vasospasm after subarachnoid hemorrhage (SAH). As the effectiveness of clazosentan for patients over 75 years old and those with World Federation of Neurosurgical Societies grade V has not been established, we aimed to evaluate its efficacy in real-world clinical settings. This study utilized prospectively collected data from consecutive SAH patients across 4 stroke centers, comparing 187 patients treated with clazosentan to 223 patients receiving standard of care. The incidence of favorable functional outcomes (modified Rankin Scale score 0-2) at 90 days after SAH, occurred more frequently in patients receiving clazosentan (74.9% vs 65.0%, p = 0.032). Multiple logistic analyses identified clazosentan administration as independently associated with favorable functional outcomes (49.1% vs 37.6%, odds ratio 2.17 [1.22-3.85], p = 0.008). Angiographic vasospasm (25.7% vs 48.9%, p < 0.001) and vasospasm-related infarcts (11.8% vs 20.2%, p = 0.023) were less frequent among patients receiving clazosentan. Stratification analyses revealed that clazosentan usage increased the incidence of favorable functional outcomes regardless of age, sex, SAH severity, and clot volume. These results underscore the therapeutic potential of clazosentan against cerebral vasospasm independent of patient characteristics.
Whole-Brain Millisecond-Scale Effective Connectivity Atlas of Auditory and Visual Naming

Ryuzaburo Kochi, Aya Kanno, Hiroshi Uda, Keisuke Hatano, Masaki Sonoda, Hidenori Endo, Michael Cools, Robert Rothermel, Aimee F. Luat, Eishi Asano

2025年11月18日

DOI： 10.1101/2025.11.18.689014 　
Endoscope-integrated indocyanine green videoangiography for craniocervical dural arteriovenous fistula with ruptured anterior spinal artery aneurysm: a case report and review of the literature. 国際誌

Tomohisa Ishida, Tomohiro Kawaguchi, Hiroyuki Sakata, Hidenori Endo

Journal of medical case reports　19　(1)　583-583　2025年11月17日

DOI： 10.1186/s13256-025-05575-7 　

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BACKGROUND: Treatment for arteriovenous fistulas located at the craniocervical junction involving the pial feeder aneurysm is challenging. When a direct aneurysm manipulation is not feasible, shunt interception to achieve flow reduction is a considerable option. However, a potential risk for remnant or recurrence of aneurysm may exist due to residual minor shunt flow from small vessels that are undetectable using conventional digital subtraction angiography. CASE PRESENTATION: A 44-year-old Asian man presented with sudden-onset left occipital headache, right thermoanesthesia, and left hemiparesis due to hematomyelia of the cervical spine. Digital subtraction angiography revealed epidural arteriovenous fistula with aneurysmal formation on the anterior spinal artery. As a direct approach to the aneurysm was difficult, the anterior spinal artery was intercepted from the fistula. During surgery, an endoscope-integrated indocyanine green videoangiography allows a clear visualization of abnormal small vessels that were not fully evaluated using digital subtraction angiography. Although the aneurysm blood flow was remnant, shunt interception was confirmed through endoscopic findings of disappearance of blood flow to these small vessels, leading to subsequent aneurysm obliteration. CONCLUSION: In the treatment of dural arteriovenous fistulas with anterior spinal artery aneurysm, a more precise assessment of small vessels and their occlusion is possible through the use of an endoscope-integrated indocyanine green videoangiography.
未破裂脳動脈瘤に対する血管内治療における脳梗塞発生危険因子の検討

佐野顕史, 面高俊介, 坂田洋之, 佐藤吉通, 内田浩喜, 鹿毛淳史, 園田順彦, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　41回　430-430　2025年11月
出版者・発行元： (一社)日本脳神経血管内治療学会
eISSN：2759-6907
破裂内頸動脈血豆状動脈瘤治療における虚血性合併症の検討

鹿毛淳史, 内田浩喜, 坂田洋之, 田代亮介, 佐藤吉通, 面高俊介, 新妻邦泰, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　41回　451-451　2025年11月
出版者・発行元： (一社)日本脳神経血管内治療学会
eISSN：2759-6907
前方循環系頭蓋内主幹動脈狭窄症の臨床像と狭窄進行のバイオマーカー探索

田代亮介, 鹿毛淳史, 面高俊介, 矢澤由加子, 坂田洋之, 井上智夫, 臼杵豊展, 新妻邦泰, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　41回　649-649　2025年11月
出版者・発行元： (一社)日本脳神経血管内治療学会
eISSN：2759-6907
ステント支援下コイル塞栓術後に再発を来した脳動脈瘤に対するFlow Diverterの有効性・安全性

佐藤吉通, 坂田洋之, 田代亮介, 鹿毛淳史, 面高俊介, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　41回　747-747　2025年11月
出版者・発行元： (一社)日本脳神経血管内治療学会
eISSN：2759-6907
フローダイバーターステントSurpass Evolveの中期治療成績 Streamlineとの比較

面高俊介, 坂田洋之, 松本康史, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　41回　749-749　2025年11月
出版者・発行元： (一社)日本脳神経血管内治療学会
eISSN：2759-6907
未破裂脳動脈瘤に対する血管内治療における脳梗塞発生危険因子の検討

佐野顕史, 面高俊介, 坂田洋之, 佐藤吉通, 内田浩喜, 鹿毛淳史, 園田順彦, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　41回　430-430　2025年11月
出版者・発行元： (一社)日本脳神経血管内治療学会
eISSN：2759-6907
破裂内頸動脈血豆状動脈瘤治療における虚血性合併症の検討

鹿毛淳史, 内田浩喜, 坂田洋之, 田代亮介, 佐藤吉通, 面高俊介, 新妻邦泰, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　41回　451-451　2025年11月
出版者・発行元： (一社)日本脳神経血管内治療学会
eISSN：2759-6907
前方循環系頭蓋内主幹動脈狭窄症の臨床像と狭窄進行のバイオマーカー探索

田代亮介, 鹿毛淳史, 面高俊介, 矢澤由加子, 坂田洋之, 井上智夫, 臼杵豊展, 新妻邦泰, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　41回　649-649　2025年11月
出版者・発行元： (一社)日本脳神経血管内治療学会
eISSN：2759-6907
ステント支援下コイル塞栓術後に再発を来した脳動脈瘤に対するFlow Diverterの有効性・安全性

佐藤吉通, 坂田洋之, 田代亮介, 鹿毛淳史, 面高俊介, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　41回　747-747　2025年11月
出版者・発行元： (一社)日本脳神経血管内治療学会
eISSN：2759-6907
フローダイバーターステントSurpass Evolveの中期治療成績 Streamlineとの比較

面高俊介, 坂田洋之, 松本康史, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　41回　749-749　2025年11月
出版者・発行元： (一社)日本脳神経血管内治療学会
eISSN：2759-6907
Impact of aphasia on verbal memory: insights from the Selective Anesthesia for Functional Evaluation. 国際誌

Hana Kikuchi, Shin-Ichiro Osawa, Kazuo Kakinuma, Shoko Ota, Kazuto Katsuse, Kazushi Ukishiro, Kazutaka Jin, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

Journal of neurosurgery　143　(5)　1194-1201　2025年11月1日

DOI： 10.3171/2025.2.JNS242534 　

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OBJECTIVE: The Wada test, an intracarotid amobarbital procedure, is the gold standard for the preoperative evaluation of postoperative memory decline in patients with drug-resistant epilepsy. However, because the anesthetic perfuses the language areas, infusion into the language-dominant hemisphere also causes aphasia. Although it has been noted that aphasia may affect verbal memory scores in the Wada test, the extent of the effects has not been verified. This study aimed to examine the extent to which verbal memory is affected by aphasia induced by selective anesthetization of the proximal middle cerebral artery (M1) area (which does not affect the hippocampus) in patients with drug-resistant epilepsy. METHODS: This single-center retrospective analysis included patients with drug-resistant epilepsy who underwent the Selective Anesthesia for Functional Evaluation (SAFE) as a preoperative evaluation between May 2018 and December 2023. SAFE includes cognitive tasks of equal difficulty administered before and immediately after anesthetic infusion. The preinfusion assessments confirmed the baseline, whereas the postinfusion assessments evaluated brain function under selective anesthesia. The patients were required to memorize 8 words and 8 pictures. After the anesthetic effects subsided, recognition tasks were performed for both words and pictures. The number of words and pictures successfully recognized were counted as verbal and visual memory scores, respectively. Memory scores were compared between the left and right M1 infusions. RESULTS: Of the 180 SAFE trials conducted during the study period, 38 trials (25 left and 13 right M1 infusions) in 29 patients with confirmed left language dominance and propofol infusion into the M1 were included. All left M1 infusions induced aphasia without causing significant disturbances in consciousness that could have interfered with task completion. The results indicated significantly lower verbal memory scores during left M1 infusions than during right M1 infusions, whereas the visual memory scores were comparable. CONCLUSIONS: The verbal memory score was significantly lower after infusion into the M1 of the language-dominant hemisphere than into the nondominant hemisphere, suggesting that aphasia during stimulus encoding may impair verbal memory. Thus, the Wada test with intracarotid anesthetic infusion may not accurately assess memory function due to aphasia. This study highlights the utility of SAFE in reducing aphasic interference in verbal memory, leading to a more accurate evaluation of surgical candidacy in patients with epilepsy.
White matter lesions associated with the reemergence of grasp reflexes in patients with idiopathic normal pressure hydrocephalus

Junyan Liu, Shigenori Kanno, Chifumi Iseki, Nobuko Kawakami, Kazuo Kakinuma, Kazuto Katsuse, Shiho Matsubara, Shoko Ota, Keiko Endo, Kentaro Takanami, Shin-ichiro Osawa, Tomohiro Kawaguchi, Hidenori Endo, Shunji Mugikura, Kyoko Suzuki

Fluids and Barriers of the CNS　22　(1)　2025年10月27日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1186/s12987-025-00718-w 　

eISSN：2045-8118
Postsurgical psychogenic non-epileptic seizure: a treatment-related functional neurological disorder

Shin-ichiro Osawa, Maimi Ogawa, Hirotaka Iwaki, Yuko Akitsuki, Mayu Fujikawa, Kazushi Ukishiro, Kazutaka Jin, Atsushi Sakuma, Hiroaki Tomita, Kyoko Suzuki, Nobukazu Nakasato, Hidenori Endo

Journal of Neurology, Neurosurgery & Psychiatry　jnnp-2025　2025年10月5日
出版者・発行元： BMJ
DOI： 10.1136/jnnp-2025-336913 　

ISSN：0022-3050

eISSN：1468-330X
大脳機能マッピングの現状と展望選択的脳領域麻酔による新規機能マッピング法の確立

大沢伸一郎, 鈴木匡子, 柿沼一雄, 菊地花, 浮城一司, 石田誠, 勝瀬一登, 太田祥子, 下田由輝, 新妻邦泰, 神一敬, 遠藤英徳

臨床神経生理学　53　(5)　494-494　2025年10月
出版者・発行元： (一社)日本臨床神経生理学会
ISSN：1345-7101

eISSN：2188-031X
もやもや病患者における糞便中Lactococcus lactisの欠乏と短鎖脂肪酸の変化

大友真優子, 田代亮介, 徳野秀尚, 鹿毛淳史, 冨永慶太, 永井新, 相川亨, 安藤大祐, 坂田洋之, 佐藤岳哉, 冨永悌二, 阿部高明, 新妻邦泰, 遠藤英徳

脳循環代謝　37　(1)　89-89　2025年10月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN：0915-9401

eISSN：2188-7519
もやもや病患者における糞便中Lactococcus lactisの欠乏と短鎖脂肪酸の変化

大友真優子, 田代亮介, 徳野秀尚, 鹿毛淳史, 冨永慶太, 永井新, 相川亨, 安藤大祐, 坂田洋之, 佐藤岳哉, 冨永悌二, 阿部高明, 新妻邦泰, 遠藤英徳

脳循環代謝　37　(1)　89-89　2025年10月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN：0915-9401

eISSN：2188-7519
Clinical effect of radical debris evacuation with a flexible neuroendoscope on patients with ventriculitis: a case series

Takeyoshi Honta, Tomohiro Kawaguchi, Hiroki Uchida, Shunsuke Omodaka, Kuniyasu Niizuma, Hidenori Endo

Journal of Medical Case Reports　19　(1)　2025年9月29日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1186/s13256-025-05541-3 　

eISSN：1752-1947
てんかん診療における心理職の役割てんかん患者に対するテキストベース遠隔心理支援の可能性

小川舞美, 浮城一司, 藤川真由, 亀井幹子, 小木曽由佳, 古村智, 遠藤英徳, 中里信和, 神一敬

てんかん研究　43　(2)　308-309　2025年9月
出版者・発行元： (一社)日本てんかん学会
ISSN：0912-0890

eISSN：1347-5509
Retrospective interviews reveal unawareness of weakness following reversible hemispheric suppression: An exploratory study using selective anesthesia for functional evaluation. 国際誌

Hiroaki Hosokawa, Kazuo Kakinuma, Shin-Ichiro Osawa, Hana Kikuchi, Kazuto Katsuse, Shoko Ota, Erena Kobayashi, Nobuko Kawakami, Marie Oyafuso, Kazushi Ukishiro, Kazutaka Jin, Makoto Ishida, Kuniyasu Niizuma, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

Cortex; a journal devoted to the study of the nervous system and behavior　190　146-154　2025年9月

DOI： 10.1016/j.cortex.2025.06.015 　

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Unawareness of weakness-defined as an explicit failure to recognize one's own limb paresis after brain damage-has long been considered predominantly linked to right-hemisphere dysfunction, yet its laterality remains controversial. We retrospectively analyzed 86 sessions of Selective Anesthesia for Functional Evaluation (SAFE) conducted in 53 patients with surgical epilepsy. SAFE involves delivering a short-acting anesthetic into a single cortical artery branch, resulting in reversible cortical suppression. Contralateral weakness was defined as a positive Barré sign in the upper limb, corresponding to a Manual Muscle Test score of <3. Following the anesthetic effect, patients were asked whether they had experienced any motor impairment. Explicit unawareness was probed using two standardized questions, followed by a limb-specific inquiry. Interviews were conducted in real-time during 28 infusions and repeated within 30 sec of motor recovery in the remaining 58 sessions. Unawareness occurred in 41 of 52 left-hemisphere infusions (78.8%) and in 26 of 34 right-hemisphere infusions (76.5%). Real-time and immediate post hoc ratings were concordant in 26 of 28 paired assessments (93%). Infusions into the M2-superior division were associated with higher rates of unawareness than those into the M2-inferior division (odds ratio = 2.3, 95% confidence interval: 1.1-5.1). Within this reversible perfusion-suppression model, the frequency of unawareness of weakness was hemispherically balanced, promoting a cautious re-evaluation of the presumed right-hemisphere dominance. SAFE provides a practical tool for isolating transient awareness deficits without structural injury and may help bridge pharmacological and lesion-based approaches to brain-behavior mapping.
Localization of the Epileptogenic Zone Using Neural Spatial Volatility in Epilepsy Surgery. 国際誌

Naoto Kuroda, Hiroshi Uda, Keiki Inoue, Yu Kitazawa, Shin-Ichiro Osawa, Hitoshi Nemoto, Makoto Ishida, Kazushi Ukishiro, Aimee F Luat, Hidenori Endo, Nobukazu Nakasato, Eishi Asano

Neurology　105　(4)　e213906　2025年8月26日

DOI： 10.1212/WNL.0000000000213906 　

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BACKGROUND AND OBJECTIVES: Diseased tissues in the human brain frequently exhibit marked alterations in structural and functional properties compared with adjacent, unaffected regions, whereas healthy tissues display intrinsic, milder topographical variability in these properties. We hypothesized that the epileptogenic zone responsible for drug-resistant focal seizures would be characterized by pronounced alterations in electrographic properties relative to adjacent regions. METHODS: This international, multicenter observational study aimed to test this hypothesis by studying patients with drug-resistant focal epilepsy who underwent curative epilepsy surgery following intracranial EEG (iEEG) recording, with at least 1 year of postoperative follow-up. In this study, "neural spatial volatility" was defined as differences in interictal high-frequency electrographic measures compared with adjacent areas. We tested whether greater neural spatial volatility in resected compared to preserved sites predicts postoperative seizure freedom, independently of clinical, neuroimaging, and ictal iEEG data. In addition, we examined whether incorporating neural spatial volatility into an outcome prediction model, based on the standard-care presurgical evaluation, would improve its performance. RESULTS: In a derivation cohort of 140 patients with 14,933 samples of iEEG electrodes (mean age 13.1 years; female 68 [48.6%]; postoperative seizure freedom 98 [70.0%]), greater neural spatial volatility in resected compared with preserved sites was an independent predictor of postoperative seizure freedom. The outcome prediction model considering the neural spatial volatility improved the classification performance, showing the area under the curve up to 0.825 (95% CI 0.747-0.902; p < 1.0 × 10-15). This result was validated in an independent test dataset of 26 patients with 1,626 samples of iEEG electrodes (mean age 25.7 years; female 14 [53.8%]; postoperative seizure freedom 16 [61.5%]) at a different institution, showing the improvement of prediction performance up to 0.819 (95% CI 0.653-0.985; p < 0.0005). DISCUSSION: Despite the limitations of the retrospective study and the relatively small validation cohort, our findings suggest that increased heterogeneity in the mesoscale distribution of interictal high-frequency activity is a distinguishing feature of the epileptogenic zone in drug-resistant focal epilepsy, potentially offering a novel marker for its localization.
Ischemic stroke rewires the neuronal translatome via stress-induced stop codon readthrough, frameshifting, and codon-biased translation

Sherif Rashad, Yuki Kitamura, Tomohito Nagai, Daisuke Ando, Abdulrahman Mousa, Hajime Ikenouchi, Hidenori Endo, Kuniyasu Niizuma

2025年8月16日

DOI： 10.1101/2025.08.15.670488 　
Repeated recurrence after endovascular treatment for cerebral aneurysms: predictive clinical factors and optimal therapeutic management

Kota Kurisu, Hiroyuki Sakata, Yasushi Matsumoto, Atsushi Kanoke, Shunsuke Omodaka, Miki Fujimura, Hidenori Endo

Neurosurgical Review　2025年8月16日

DOI： 10.1007/s10143-025-03758-w 　
Spatiotemporal dynamics of reading Kana (syllabograms) and Kanji (morphograms). 国際誌

Kazuto Katsuse, Kazuo Kakinuma, Shin-Ichiro Osawa, Shoko Ota, Hana Kikuchi, Ai Kawamura, Kazushi Ukishiro, Kazuyo Tanji, Nobuko Kawakami, Chifumi Iseki, Shigenori Kanno, Yuichiro Shirota, Masashi Hamada, Tatsushi Toda, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

NeuroImage　317　121316-121316　2025年8月15日

DOI： 10.1016/j.neuroimage.2025.121316 　

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Reading engages complex neural networks integrating visual, phonological, and semantic information. The dual-stream model posits ventral and dorsal pathways for lexical and sublexical processing in the left hemisphere and is well-supported in alphabetic languages. However, its applicability to non-alphabetic scripts remains unclear. The Japanese writing system, comprising Kana (syllabograms) and Kanji (morphograms) with distinct orthographic, phonological, and semantic properties, provides a unique framework to investigate neural dissociation between phonological and orthographic-semantic processing. Previous studies suggest that Kanji relies on the ventral route for whole-word recognition and semantic processing, whereas Kana depends mainly on the dorsal route for phonological decoding via grapheme-to-phoneme conversion; however, their spatiotemporal dynamics remain unknown. Using high-gamma power analysis from electrocorticography recordings in 14 patients with epilepsy and subdural implants, we examined the spatiotemporal neural dynamics of Kana and Kanji reading. Participants completed a visual lexical decision task with Kana and Kanji words and pseudowords. Across 912 electrodes, differential high-gamma power analysis showed that Kanji activated bilateral occipitotemporal fusiform regions early (120-550 ms) and the left inferior temporal gyrus (150-240 ms). Conversely, Kana showed prolonged late activation (270-750 ms) in the left-lateralised superior temporal, supramarginal, and inferior frontal gyri, especially during pseudoword processing. These findings indicate that Kanji relies on bilateral ventral stream earlier, while Kana depends on the left dorsal stream, with slower processing reflecting the extra grapheme-to-phoneme conversion. This underscores the value of non-alphabetic languages in elucidating both universal and script-specific neural mechanisms, advancing a cross-linguistic understanding of the reading network.
Dynamic Causal White Matter Atlas of Auditory and Visual Speech Networks at Millisecond Resolution: Intracranial Evidence from 125 Patients

Ryuzaburo Kochi, Aya Kanno, Hiroshi Uda, Keisuke Hatano, Hidenori Endo, Michael Cools, Robert Rothermel, Aimee F. Luat, Eishi Asano

2025年7月16日

DOI： 10.1101/2025.07.15.664981 　
Visualization of functional and effective connectivity underlying auditory descriptive naming. 国際誌

Yu Kitazawa, Kazuki Sakakura, Hiroshi Uda, Naoto Kuroda, Riyo Ueda, Ethan Firestone, Min-Hee Lee, Jeong-Won Jeong, Masaki Sonoda, Shin-Ichiro Osawa, Kazushi Ukishiro, Makoto Ishida, Kazuo Kakinuma, Shoko Ota, Yutaro Takayama, Keiya Iijima, Toshimune Kambara, Hidenori Endo, Kyoko Suzuki, Nobukazu Nakasato, Masaki Iwasaki, Eishi Asano

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology　175　2010729-2010729　2025年7月

DOI： 10.1016/j.clinph.2025.04.008 　

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OBJECTIVE: We visualized functional and effective connectivity within specific white matter networks in response to auditory descriptive questions. METHODS: We investigated 40 Japanese-speaking patients with focal epilepsy and estimated connectivity measures using cortical high-gamma dynamics and MRI tractography. RESULTS: Hearing a wh-interrogative at question onset enhanced inter-hemispheric functional connectivity, with left-to-right callosal facilitatory flows between the superior-temporal gyri, contrasted by functional connectivity diminution with right-to-left callosal suppressive flows between dorsolateral prefrontal regions. Processing verbs associated with concrete objects or adverbs increased left intra-hemispheric connectivity, with bidirectional facilitatory flows through extensive white matter pathways. Questions beginning with what, compared to where, induced greater neural engagement in the left posterior inferior-frontal gyrus at question offset, linked to enhanced functional connectivity and bidirectional facilitatory flows to the temporal lobe neocortex via the arcuate fasciculus. During overt responses, inter-hemispheric functional connectivity was enhanced, with bidirectional callosal flows between Rolandic areas, and individuals with higher IQ scores exhibited less prolonged neural engagement in the left posterior middle frontal gyrus. CONCLUSIONS: Visualization of directional neural interactions within white matter networks during overt naming is feasible. SIGNIFICANCE: Phrase order may influence network dynamics in listeners, even when presented with auditory descriptive questions conveying similar meanings.
Diagnostic Values of the "To and Fro" Conflict Sign on Intraoperative Indocyanine Green Video Angiography as a Warning Sign of the Focal Cerebral Hyperperfusion and Watershed Shift Phenomenon after Superficial Temporal Artery-Middle Cerebral Artery Bypass for Adult Patients with Moyamoya Disease. 国際誌

Ryosuke Tashiro, Miki Fujimura, Taketo Nishizawa, Keita Tominaga, Atushi Kanoke, Hidenori Endo

Cerebrovascular diseases (Basel, Switzerland)　1-8　2025年6月12日

DOI： 10.1159/000546826 　

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INTRODUCTION: The focal cerebral hyperperfusion (CHP) is a potential complication after superficial temporal artery-middle cerebral artery (STA-MCA) bypass for moyamoya disease (MMD) that can result in delayed intracerebral hemorrhage and/or neurological deterioration. The focal CHP could accompany hemodynamic ischemia due to the "watershed shift (WS) phenomenon." Preoperative prediction of the focal CHP and WS phenomenon remains challenging. Here, we aimed to assess the diagnostic value of the "to and fro" conflict sign, conflicting blood flow around the vascular territory of the recipient arteries on an indocyanine green video angiography (ICG-VA) for predicting the focal CHP and WS phenomenon. METHODS: Ninety-seven consecutive adult patients with MMD, undergoing 106 surgeries, were enrolled. Serial quantitative analysis of cerebral blood flow was routinely conducted using <sc>n</sc>-isopropyl-p-[123I] iodoamphetamine single-photon emission computed tomography preoperatively and postoperative day 1 and 7 after STA-MCA bypass. The association between the "to and fro" conflict sign on ICG-VA and the focal CHP/WS phenomenon incidence was then analyzed. RESULTS: The incidence of the focal CHP and WS phenomenon was 29.2% (31/106) and 10.4% (11/106), respectively. The "to and fro" conflict sign was evident in 35.5% (11/31) and 54.5% (6/11) of MMD patients with the focal CHP and WS phenomenon, respectively. The "to and fro" conflict sign was significantly associated with both the focal CHP and WS phenomena. CONCLUSION: The "to and fro" conflict sign on ICG-VA may serve as an intraoperative warning sign of the focal CHP and WS phenomenon after STA-MCA bypass in adult patients with MMD, providing neurosurgeons with a valuable tool for early detection.
顕著な脳変形を有する松果体部腫瘍摘出 Lobar type holoprosencephalyを伴って出生後17歳時に松果体部未分化奇形腫を発症しhigh parietal approachにて全摘出し得た一例

木我隆, 柴原一陽, 犬飼円, 金森政之, 遠藤英徳, 隈部俊宏

小児の脳神経　50　(2)　137-137　2025年6月
出版者・発行元： (一社)日本小児神経外科学会
ISSN：0387-8023

eISSN：2435-824X
くも膜下出血術後管理におけるクラゾセンタンのリアルワールドデータ

遠藤英徳, 坂田洋之, 鹿毛淳史, 内田浩喜, 面高俊介, 新妻邦泰

くも膜下出血と脳血管攣縮　39-40　81-81　2025年6月
出版者・発行元： SAH
ISSN：2759-2405
Type 2 diabetes abates retrograde collateral flow and promotes leukocyte adhesion following ischemic stroke

Yoshimichi Sato, Yuya Kato, Atsushi Kanoke, Jennifer Y Sun, Yasuo Nishijima, Ruikang K Wang, Michael Stryker, Hidenori Endo, Jialing Liu

Journal of Cerebral Blood Flow & Metabolism　45　(9)　1684-1701　2025年5月29日
出版者・発行元： SAGE Publications
DOI： 10.1177/0271678x251338203 　

ISSN：0271-678X

eISSN：1559-7016

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Type 2 diabetes mellitus (T2DM) is associated with impaired leptomeningeal collateral compensation and poor stroke outcome. Neutrophils tethering and rolling on endothelium after stroke can also independently reduce flow velocity. However, the chronology and topological changes in collateral circulation in T2DM is not yet defined. Here, we describe the spatial and temporal blood flow dynamics and vessel diameter changes in pial arteries and veins and leukocyte-endothelial adhesion following middle cerebral artery (MCA) stroke using two-photon microscopy in awake control and T2DM mice. Relative to control mice, T2DM mice already exhibited smaller pial vessels with reduced flow velocity prior to stroke. Following stroke, T2DM mice displayed persistently reduced blood flow in pial arteries and veins, resulting in a poor recovery of downstream penetrating arterial flow and a sustained deficit in microvascular flow. There was also persistent increase of leukocyte adhesion to the endothelium of veins, coincided with elevated neutrophils infiltration into brain parenchyma in T2DM mice compared to control mice after stroke. Our data suggest that T2DM-induced increase in inflammation and chronic remodeling of leptomeningeal vessels may contribute to the observed hemodynamics deficiency after stroke and subsequent poor stroke outcome.
Serum Lactate–Based Stratification for Seizure Diagnosis in Resource-Limited Neurologic Emergency Settings

Shin-ichiro Osawa, Satoshi Miyata, Kensuke Fujita, Tsuyoshi Kawamura, Ichiro Suzuki, Kensuke Kimura, Toshimi Okushima, Akihide Konn, Hidenori Endo

2025年5月4日

DOI： 10.1101/2025.05.01.25326838 　
再発IDH-mutant astrocytomaにおけるCDKN2A/B欠失と再発後の転帰の解析

山下将太, 金森政之, 長田佳整, 下田由輝, 渡辺みか, 柴原一陽, 齋藤竜太, 園田順彦, 隈部俊宏, 遠藤英徳

Brain Tumor Pathology　42　(Suppl.)　089-089　2025年5月
出版者・発行元：日本脳腫瘍病理学会
ISSN：1433-7398

eISSN：1861-387X
神経繊維腫症1型(NF1)に合併した悪性神経膠腫の比較検討

相川享, 金森政之, 長田佳整, 下田由輝, 渡邉裕文, 渡辺みか, 柴原一陽, 園田順彦, 隈部俊宏, 遠藤英徳

Brain Tumor Pathology　42　(Suppl.)　090-090　2025年5月
出版者・発行元：日本脳腫瘍病理学会
ISSN：1433-7398

eISSN：1861-387X
抗血栓薬休薬中の院内発症脳梗塞における臨床的特徴

岩本憲宏, 庄司拓大, 新妻邦泰, 吉田昌弘, 冨永悌二, 遠藤英徳

脳卒中の外科　53　(3)　151-159　2025年5月
出版者・発行元： (一社)日本脳卒中の外科学会
ISSN：0914-5508

eISSN：1880-4683
A Novel Use of Intracranial Arterial Pressure Waveforms to Detect Occlusive events

Ryuzaburo Kochi, Eishi Asano, Yoshiteru Shimoda, Atsushi Kanoke, Shunsuke Omodaka, Hiroyuki Sakata, Kanako Sato, Yasuhiro Suzuki, Kuniyasu Niizuma, Yasushi Matsumoto, Hidenori Endo

2025年4月30日
出版者・発行元： Cold Spring Harbor Laboratory
DOI： 10.1101/2025.04.28.25326342 　

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Abstract During neuroendovascular treatment, unexpected occlusive events, such as thrombosis, may occur and can cause severe complications. However, angiography provides only intermittent assessments of intravascular conditions, underscoring the need for continuous monitoring. In this retrospective study, we examined whether intracranial arterial pressure waveforms recorded via a catheter could detect occlusive events. A total of 6,442 waveform trials from 43 arteries in 37 patients, each assessed in both patent and occluded states, were analyzed. Time-frequency amplitude (TFA) was calculated via wavelet transformation in selected frequency ranges (6 to 10, 10 to 14, 14 to 18, and 6 to 18 Hz). A mixed-model analysis revealed that TFA was significantly higher under occluded conditions (p < 0.001). Specifically, when focusing on the 6 to 18 Hz range and using a 113.9% elevation in TFA from the initial patent baseline as a threshold, the average sensitivity, specificity, positive predictive value, and negative predictive value for detecting occlusion were 88.5%, 87.5%, 36.1%, and 96.4%, respectively. These findings suggest that continuous waveform analysis may serve as a valuable complement to intermittent angiographic assessments, potentially enhancing both safety and therapeutic outcomes in neuroendovascular procedures.
Decreased Lactococcus lactis and propionic acid in feces of patients with Moyamoya disease: Possible implications of immune dysregulation. 国際誌

Mayuko Otomo, Ryosuke Tashiro, Hidetaka Tokuno, Atsushi Kanoke, Keita Tominaga, Arata Nagai, Takashi Aikawa, Daisuke Ando, Hiroyuki Sakata, Takeya Sato, Takaaki Abe, Hidenori Endo, Kuniyasu Niizuma, Teiji Tominaga

Cerebrovascular diseases (Basel, Switzerland)　1-15　2025年3月26日

DOI： 10.1159/000545478 　

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INTRODUCTION: Moyamoya disease (MMD) is a cerebrovascular disease characterized by progressive steno-occlusive lesions in the terminal portion of the internal carotid artery. Despite its unknown etiology, immune dysregulation is regarded as a critical trigger for delineating the pathophysiology of MMD. The gut microbiota produces short-chain fatty (SCFA) and organic acids, influencing immune regulation and vascular remodeling. We aimed to characterize the gut microbiota in patients with MMD. METHODS: Sixteen patients with MMD and sixteen healthy controls were included in this study. We performed 16S rRNA sequencing of fecal samples and analyzed microbiome diversity and composition, and quantified SCFA and organic acid levels using liquid chromatography. RESULTS: There were no significant differences in α- and b-diversities among feces from the MMD patients and controls. However, 16S rRNA sequencing identified defective Lactococcus lactis (0 ± 0 in the MMD patients vs. 0.026 ± 0.084 in healthy controls, p = 0.0181) and abundant Gordinobacter pamelaeae (0.030±0.039 in the patients vs. 0.001±0.005 in healthy controls, p = 0.003) are strongly linked to MMD. Propionic acid levels were significantly lower in feces of the MMD patients compared to healthy controls (0.83 ± 0.34 mg/g in the MMD patients vs. 1.20 ± 0.55 mg/g in healthy controls, p = 0.028). CONCLUSION: Decreased Lactococcus lactis can result in reduced lactic acid and propionic acid levels in the feces of the patients. This imbalance in the gut microbiome and SCFA/organic acid levels could contribute to immune dysregulation underlying the vascular remodeling seen in MMD.
Intraoperative Superficial Temporal Artery-middle Cerebral Artery Bypass Failure during Combined Bypass Surgery in Children with Moyamoya Disease.

Toshiaki Hayashi, Tomomi Kimiwada, Keita Tominaga, Hidenori Endo

Neurologia medico-chirurgica　65　(3)　133-140　2025年3月15日

DOI： 10.2176/jns-nmc.2024-0242 　

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Pediatric patients with moyamoya disease frequently show rapid progression with a high risk of stroke. Indirect revascularization is widely accepted as a surgical treatment for pediatric moyamoya disease, but it does not augment cerebral blood flow immediately, which leaves patients at risk for stroke peri-operatively. This delay in flow augmentation may make adding direct bypass the better option. This study documents our cases of direct bypass failure that underwent indirect bypass supplemented with superficial temporal artery-middle cerebral artery bypass to evaluate the adverse effects of direct bypass failure. A retrospective review of all surgeries for pediatric moyamoya disease after introducing intraoperative indocyanine green videoangiography to confirm direct bypass patency identified 78 surgical hemispheres. Direct bypass failure was defined as failure to confirm blood flow from the superficial temporal artery to the middle cerebral artery on indocyanine green videoangiography. The occurrence of ischemic complications was evaluated by magnetic resonance imaging. During the period, postoperative ischemic complications were seen in 3 surgical hemispheres (3.8%) and one contralateral hemisphere (1.3%). One case in which hyperventilation was difficult to control postoperatively developed extensive cerebral infarction. Direct bypass failure was seen in 3 patients (3.8%), none of whom had additional cerebral infarction on magnetic resonance imaging. The results of this study indicate that failure of direct bypass surgery does not necessarily lead to cerebral infarction. Based on these results, surgeons can safely attempt to add a direct bypass to an indirect bypass, with special attention to perioperative patient management.
Disease progression, transient ischemic attack, and de novo parenchymal lesions in asymptomatic moyamoya disease: results of a 5-year interim analysis of the AMORE study. 国際誌

Satoshi Kuroda, Shusuke Yamamoto, Takeshi Funaki, Miki Fujimura, Hiroharu Kataoka, Tomohito Hishikawa, Jun C Takahashi, Hidenori Endo, Tadashi Nariai, Toshiaki Osato, Nobuhito Saito, Norihiro Sato, Emiko Hori, Daina Kashiwazaki, Yoichi M Ito, Susumu Miyamoto

Journal of neurosurgery　142　(3)　658-666　2025年3月1日

DOI： 10.3171/2024.6.JNS24736 　

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OBJECTIVE: Recently, the authors have reported the 5-year risk of stroke in patients with asymptomatic moyamoya disease (MMD). In this report, the aim was to clarify patients' 5-year risk of disease progression, transient ischemic attack (TIA), and de novo parenchymal lesions and to identify their predictors. METHODS: This multicenter, prospective cohort study (Asymptomatic Moyamoya Registry [AMORE]) in Japan is still ongoing. Participants were enrolled if they were 20-70 years of age, had bilateral or unilateral MMD, experienced no episodes suggestive of TIA and stroke, were functionally independent (modified Rankin Scale score of 0 or 1), and had been followed up for 10 years. Clinical and radiological data were obtained at enrollment and annually thereafter for 5 years. In this 5-year interim analysis, the authors defined disease progression, TIA, and de novo parenchymal lesions as the secondary endpoints. The predictors for these events were identified, using a stratification analysis method. RESULTS: A total of 103 patients were enrolled and prospectively followed up for 5 years. On annual MRA examinations, disease progression occurred in 39 hemispheres in 26 patients. The incidence of disease progression was 5.9% per patient-year, and the predictors included younger age (OR 5.72, 95% CI 1.28-25.56; p = 0.0223) and hypercholesterolemia (OR 5.41, 95% CI 1.37-21.28; p = 0.0158). TIA occurred in 12 hemispheres in 10 patients, for an incidence of 2.3% per patient-year. The disease progression prior to TIA was a significant predictor for TIA (OR 5.00, 95% CI 1.31-19.0; p = 0.0184). De novo microbleeds were found in 11 hemispheres in 10 patients (2.3% per patient-year). The presence of microbleeds at enrollment was a significant predictor for de novo microbleeds (OR 5.53, 95% CI 1.17-26.13; p = 0.0309). CONCLUSIONS: Patients with asymptomatic MMD may carry a significant risk of disease progression, TIA, and de novo microbleeds during the first 5 years after initial diagnosis. Practitioners should very carefully follow up with them to improve their outcome, using MRI and MRA at regular intervals. Clinical trial registration no.: UMIN000006640 (https://www.umin.ac.jp).
Intraoperative aneurysm flow analysis predicts intracranial large and giant aneurysm occlusion after flow diversion

Yoshinari Osada, Hiroyuki Sakata, Masayuki Ezura, Kenichi Sato, Keisuke Sasaki, Shunsuke Omodaka, Atsushi Kanoke, Hiroki Uchida, Hidenori Endo

Clinical Neurology and Neurosurgery　2025年3月

DOI： 10.1016/j.clineuro.2025.108782 　
Perforating artery injury as a critical factor besides cortical dysfunction in motor deficit after peri-rolandic epilepsy surgery. 国際誌

Atsuhiko Ninomiya, Shin-Ichiro Osawa, Kyoko Suzuki, Kazuo Kakinuma, Kazushi Ukishiro, Yoshiteru Shimoda, Kazutaka Jin, Mitsugu Uematsu, Shiho Sato, Shunji Mugikura, Hiroyoshi Suzuki, Hajime Miyata, Shingo Kayano, Nobukazu Nakasato, Hidenori Endo

Journal of neurosurgery　1-13　2025年2月14日

DOI： 10.3171/2024.10.JNS24878 　

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OBJECTIVE: Surgery for peri-rolandic epilepsy requires appropriate consideration to balance the functional risk of postoperative motor deficit and seizure outcome. Based on voxel-based morphometric analysis, the authors hypothesized that cortical damage and ischemic subcortical damage related to surgery could affect postoperative motor deterioration. METHODS: Sixteen patients with peri-rolandic epilepsy who underwent resective surgery at a single institution were retrospectively investigated. Their imaging findings, postoperative seizure outcomes, and postoperative neurological deteriorations in motor function, as well as duration, were analyzed. Using the standardized MRI data of each case, the authors examined the surgically resected area on high-resolution 3D MR images and the high-intensity area on diffusion-weighted images, which were converted to voxel data. These voxel data were superimposed on a standard brain image for neuroimaging assessment. Postoperative motor deterioration of the orofacial region, upper limb, or lower limb was noted as no, transient, or permanent deterioration and analyzed in relation to the surgically resected area and subcortical damage. Univariate analysis of the clinical factors was conducted between cases with permanent upper- and/or lower-limb motor deterioration and those with no or transient deterioration. RESULTS: The mean follow-up period was 28 months. Ten patients (62.5%) achieved Engel class I. Fourteen patients (87.5%) experienced postoperative motor deteriorations in the following areas (no/transient/permanent): orofacial (11/5/0), upper limb (9/5/2), and lower limb (9/3/4). All cases with orofacial motor deterioration underwent cortical resection of the inferior third of the peri-rolandic cortex. Cortical resection of the precentral gyrus only, in contrast to both the precentral and postcentral gyri, was not associated with permanent upper- and/or lower-limb motor deterioration. Cortical resection involving the postcentral gyrus was significantly associated with permanent upper- and/or lower-limb motor deterioration in 4 cases (25.0%). Surgically related perforating artery injury caused ischemic subcortical damage, which was significantly associated with postoperative transient or permanent motor deterioration by extending to the corticospinal tract (CST). CONCLUSIONS: Postoperative motor deterioration for peri-rolandic epilepsy was related to both the resected cortex and ischemic subcortical damage. In peri-rolandic epilepsy, cortical resection of the precentral gyrus might not necessarily cause permanent upper- and/or lower-limb motor deterioration because of the functional reserve in other peri-rolandic areas outside the epileptic focus. On the other hand, cortical resection of the postcentral gyrus could cause permanent upper- and/or lower-limb motor deterioration because of injury to the vasculature, which is crucial for the descending motor pathway in the CST.
Multilineage-differentiating stress-enduring cells attenuate the cognitive impairment caused by chronic cerebral hypoperfusion in rats. 国際誌

Naoya Iwabuchi, Hiroki Uchida, Takatsugu Abe, Takumi Kajitani, Daiki Aburakawa, Ahmed Mansour, Hidenori Endo, Teiji Tominaga, Kuniyasu Niizuma

Experimental neurology　115185-115185　2025年2月12日

DOI： 10.1016/j.expneurol.2025.115185 　

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Multilineage-differentiating stress-enduring (Muse) cells are non-tumorigenic pluripotent- like stem cells that can migrate to damaged sites and contribute to tissue repair. Chronic cerebral hypoperfusion (CCH), which mimics vascular dementia, causes hippocampal neuronal degeneration and white matter (WM) damage, which lead to cognitive dysfunction. Currently, there are no effective treatments for it. We evaluated the efficiency of the human-Muse cell-based product CL2020 in treating CCH in rats. A bilateral common carotid artery occlusion was used to induce cognitive dysfunction. Six-weeks after carotid artery occlusion, CL2020 were injected intravenously. Cognitive function was assessed using a Barnes circular maze (BCM) at 3 weeks after CL2020 administration. Histological findings and western blots were assessed at 4 weeks after CL2020 administration. BCM assessment indicated recovery in cognitive function in the CL2020-treated group. Compared with the vehicle, CL2020 targeted the hippocampus, where it decreased neuronal loss and WM damage. CL2020 also promoted angiogenesis and suppressed apoptotic cell death. Western blotting of hippocampal samples revealed the downregulation of pro- apoptotic and the upregulation of anti-apoptotic proteins in the CL2020-treated group. In conclusion, intravenous administration of CL2020 improved the cognitive deficits caused by CCH, partly because of decreased hippocampal neuronal loss and WM damage, and increased angiogenesis in the hippocampus.
Decoding Codon Bias: The Role of tRNA Modifications in Tissue-Specific Translation

Daisuke Ando, Sherif Rashad, Thomas J. Begley, Hidenori Endo, Masashi Aoki, Peter C. Dedon, Kuniyasu Niizuma

International Journal of Molecular Sciences　2025年1月15日

DOI： 10.3390/ijms26020706 　
Clinical effect of ventricular entry during resection of IDH-wildtype glioblastoma: A multi-institutional analysis. 国際誌

Yoshiteru Shimoda, Ichiyo Shibahara, Masayuki Kanamori, Ken-Ichiro Matsuda, Ryuta Saito, Atsushi Hozawa, Toshihiro Kumabe, Hidenori Endo, Teiji Tominaga, Yukihiko Sonoda

World neurosurgery　123643-123643　2025年1月8日

DOI： 10.1016/j.wneu.2024.123643 　

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PURPOSE: Glioblastomas contacting the subventricular zone (SVZ) are associated with poor prognosis and the impact of ventricular entry (VE) during resection remains controversial. Since glioblastomas with SVZ involvement often require VE, both SVZ involvement and VE are confounding factors. This study aimed to evaluate the effect of VE during glioblastoma resection by comparing patients with and without SVZ involvement. METHODS: This multi-institutional retrospective study reviewed newly diagnosed isocitrate dehydrogenase (IDH)-wildtype glioblastoma who underwent resection. The focus was on VE, complications, and recurrence patterns based on SVZ status. RESULTS: A total of 418 patients were included. with 278 (66.5%) undergoing VE and 140 (33.5 %) without. Patients with VE had significantly shorter overall survival (OS) than those without VE (18.6 vs. 25.6 months, p = 0.008). VE was more common in patients with SVZ tumors (94.2%) compared to non-SVZ tumors (26.3%, p < 0.0001). Notably, 44 patients with non-SVZ tumors experienced VE, whereas 15 patients with SVZ tumors did not. Regardless of SVZ status, VE did not affect the rates of complications, such as symptomatic subdural effusion, hydrocephalus, infection, or nonlocal recurrence. OS was similar with each group: for SVZ tumors, OS was 17.7 months with VE vs. 19.9 months without VE (p = 0.34), and for non-SVZ tumors, OS was 30.8 months with VE vs. 25.6 months without VE (p = 0.63). CONCLUSIONS: VE during glioblastoma resection does not impact complications or nonlocal recurrence. Surgeons may safely perform VE during resection of both SVZ and non-SVZ glioblastomas without adverse effects.
Optimal intervention for ruptured cerebral arteriovenous malformation during pregnancy. 国際誌

Youhei Takeuchi, Hiroyuki Sakata, Tomohisa Ishida, Masayuki Ezura, Hidenori Endo

Surgical neurology international　16　238-238　2025年

DOI： 10.25259/SNI_320_2025 　

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BACKGROUND: Cerebral arteriovenous malformation (AVM) is a significant cause of hemorrhagic stroke in pregnant women. The risk of rebleeding after an initial hemorrhage during pregnancy is high, necessitating aggressive intervention and careful management. However, the optimal timing and method of intervention remain unclear. In particular, there has been little discussion regarding cases in which rebleeding occurred despite aggressive intervention. We present a case of cerebral AVM with intraventricular hemorrhage during pregnancy, which subsequently rebled after a cesarean section. CASE DESCRIPTION: A 30-year-old primigravida at 27 weeks of gestation presented with a sudden headache and was diagnosed with intraventricular hemorrhage. Magnetic resonance imaging revealed a flow void in the left fusiform gyrus, confirming a Spetzler-Martin Grade 2 AVM. Due to the deep location and limited safety data on Onyx use during pregnancy, surgery was postponed until after delivery. Cesarean section was planned at 32 weeks to ensure fetal viability. No rebleeding occurred preoperatively. At 32 weeks and 2 days, a cesarean section was performed under spinal anesthesia, delivering a male infant weighing 1,567 g. Postoperative computed tomography revealed intraventricular rebleeding, although no neurological deterioration occurred. Emergency transarterial embolization (TAE) with Onyx was performed the following day, followed by another TAE and AVM resection. Angiography confirmed complete lesion removal, and both the mother and child recovered favorably. CONCLUSION: Considering the high rates of rebleeding and the significant maternal and fetal mortality, prioritizing rebleeding prevention may be a key component of the intervention strategy for ruptured AVMs during pregnancy.
Recurrent Dural Arteriovenous Fistula following Cerebral Venous Sinus Thrombosis Related to COVID-19 Vaccination: A Case Report.

Naoya Iwabuchi, Masahiro Yoshida, Moe Kumai, Yasuo Nishijima, Kuniyasu Niizuma, Hidenori Endo

NMC case report journal　12　377-382　2025年

DOI： 10.2176/jns-nmc.2024-0332 　

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Cerebral venous sinus thrombosis (CVST) is rare but serious adverse complication of coronavirus disease 2019 (COVID-19) vaccination. CVST can sometimes lead to development of dural arteriovenous fistula (DAVF), but DAVF secondary to CVST following COVID-19 vaccination is rarely reported. Here, we present a case of CVST occurring after COVID-19 vaccination, followed by subsequent development of DAVF, which was successfully treated. A 45-year-old male presented with headache and progressive visual impairment beginning 4 days after COVID-19 vaccination. Papilledema was noted. Cerebrospinal fluid pressure was elevated at 300 mmH2O, and magnetic resonance imaging (MRI) revealed right transverse sinus thrombosis, prompting initiation of anticoagulant therapy. Four months later, MRI suggested DAVF in right transverse sinus, and he was referred to our department. Digital subtraction angiography confirmed DAVF in right transverse sinus, as well as concurrent convexity DAVF and pial arteriovenous fistula over right vein of Labbé, all draining solely into right vein of Labbé. Anticoagulation therapy was discontinued due to aggressive nature of this DAVF. Transarterial embolization (TAE) with Onyx was performed in 2 sessions, achieving complete occlusion of shunt. Postoperatively, anticoagulation therapy was not resumed. Ten months later, the patient again experienced visual deterioration. Recurrence of convexity DAVF over right vein of Labbé was identified, and TAE with Onyx was performed again, resulting in successful shunt occlusion. Postoperatively, anticoagulant therapy was resumed. The patient's visual acuity gradually improved, and at 18 months post-treatment, no recurrence was observed. CVST following COVID-19 vaccination can progress to DAVF; therefore, careful follow-up is recommended.
Artificial Intelligence in Neuroendovascular Therapy: Current Applications and Future Directions.

Shinya Sonobe, Kuniyasu Niizuma, Hidenori Endo

Journal of neuroendovascular therapy　19　(1)　2025年

DOI： 10.5797/jnet.ra.2025-0073 　

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In recent years, artificial intelligence (AI) has made remarkable progress. In the near future, AI will become an indispensable technology in daily clinical practice in the field of neuroendovascular therapy. Clinicians who understand the information processing and limitations of AI will create new and comfortable working styles. This article introduces current applications of AI in the field of neuroendovascular therapy and presents a vision for its future directions.
Flow Diversion for an Extracranial Infectious Internal Carotid Pseudoaneurysm Secondary to Exudative Otitis Media: Illustrative Case

Ryo Kusaka, Yoshinari Osada, Ryosuke Tashiro, Naoya Iwabuchi, Masayuki Ezura, Kenichi Sato, Hidenori Endo

Journal of Neuroendovascular Therapy　19　(1)　n/a-n/a　2025年
出版者・発行元： The Japanese Society for Neuroendovascular Therapy
DOI： 10.5797/jnet.cr.2024-0117 　

ISSN：1882-4072

eISSN：2186-2494
A Case of Coil Embolization for an Angiographically Occult Ruptured Anterior Communicating Artery Aneurysm

Naoya Iwabuchi, Ryosuke Tashiro, Kaoru Shoji, Masayuki Ezura, Kenichi Sato, Hidenori Endo

Journal of Neuroendovascular Therapy　19　(1)　n/a-n/a　2025年
出版者・発行元： The Japanese Society for Neuroendovascular Therapy
DOI： 10.5797/jnet.cr.2024-0118 　

ISSN：1882-4072

eISSN：2186-2494
Mechanical thrombectomy for cerebral embolism due to cardiac papillary fibroelastoma: A case report. 国際誌

Kentaro Izumi, Youhei Takeuchi, Naoya Iwabuchi, Masahiro Yoshida, Kuniyasu Niizuma, Hidenori Endo

Surgical neurology international　16　141-141　2025年

DOI： 10.25259/SNI_68_2025 　

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BACKGROUND: Papillary fibroelastoma (PFE) and myxoma are relatively common types of benign cardiac tumors. PFE and myxoma can be associated with fatal embolic events. However, PFE is not widely recognized within the field of cerebrovascular diseases. CASE DESCRIPTION: A 54-year-old male presented with a sudden onset of left hemiparesis. Three-dimensional computed tomography (CT) angiography revealed incomplete occlusion of the right middle cerebral artery. Thrombolytic therapy with recombinant tissue-type plasminogen activator was performed, followed by mechanical thrombectomy. Reperfusion was achieved within 199 minutes, resulting in thrombolysis in cerebral infarction grade 2b. The retrieved emboli appeared as a white gelatinous substance, which was diagnosed as PFE by histopathological examination. Transesophageal echocardiography and cardiac CT identified a 6-mm mobile mass in the left atrium. PFE in the left atrium was considered to be the source of the embolism and tumor resection was performed on day 18. Histopathological findings of the resected tumor were identical to those of the emboli. The patient was transferred to a rehabilitation facility on day 36, with a modified Rankin Scale score of 2. CONCLUSION: PFE and myxoma share many clinical features, but PFE tends to be smaller, so detection is more challenging and has likely resulted in under-recognition. PFE and myxoma can be associated with fatal embolic events. Resection is recommended for left-sided, mobile, symptomatic tumors larger than 10 mm. The differential diagnosis of embolus retrieved through mechanical thrombectomy should consider both myxoma and PFE and persistent efforts should be made to detect the embolic origin.
A Case of Partially Thrombosed Dissecting Giant Aneurysm in the Distal Middle Cerebral Artery Treated by Endovascular Parent Artery Occlusion.

Youhei Takeuchi, Masahiro Yoshida, Yasuo Nishijima, Kuniyasu Niizuma, Hidenori Endo

NMC case report journal　12　167-173　2025年

DOI： 10.2176/jns-nmc.2024-0252 　

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Partially thrombosed and dissecting giant peripheral aneurysms present significant challenges for treatment with both direct surgical and endovascular approaches. We report a case of partially thrombosed, dissecting giant aneurysm in the peripheral segment of the middle cerebral artery treated with straightforward endovascular parent artery occlusion without saccular packing. A 30-year-old male presented with sudden loss of consciousness and subarachnoid hemorrhage and was transferred to our hospital. On admission, his level of consciousness was assessed as Japan Coma Scale 100 and Glasgow Coma Scale 8 (E1V2M5), with severe paralysis of the right upper and lower limbs. Computed tomography and magnetic resonance imaging demonstrated a partially thrombosed middle cerebral artery aneurysm with a maximum diameter of 31 mm at the M2 non-branching segment of the left middle cerebral artery mid-trunk. Cerebral angiography indicated potential collateral circulation, no retrograde opacification of the aneurysm, and absence of perforating branches near the lesion, so we selected endovascular parent artery occlusion that targeted only the proximal portion of the aneurysm. Postoperative care focused on managing intracranial pressure and overall systemic management. The patient recovered without significant infarction and was discharged home with a modified Rankin Scale score of 1 4 months after the onset. In general, peripheral aneurysms are less likely to cause perforator infarcts, and larger aneurysms are more tolerant of parent artery occlusion. Therefore, simple endovascular parent artery occlusion targeting only the proximal portion of the aneurysm offers both anatomical and pathophysiological advantages and provides a viable option when direct surgery is challenging.
選択的麻酔薬動注と認知神経学的評価を組み合わせた精密な脳機能評価

大沢伸一郎, 鈴木匡子, 柿沼一雄, 勝頼一登, 浮城一司, 金森政之, 下田由輝, 新妻邦泰, 松本康史, 神一敬, 中里信和, 遠藤英徳

てんかん研究　42　(3)　664-665　2025年1月
出版者・発行元： (一社)日本てんかん学会
ISSN：0912-0890

eISSN：1347-5509
Verbal Memory Localized in Non-language-dominant Hemisphere: Atypical Lateralization Revealed by Material-specific Memory Evaluation Using Super-selective Wada Test.

Hana Kikuchi, Shin-Ichiro Osawa, Kazuo Kakinuma, Shoko Ota, Kazuto Katsuse, Kazushi Ukishiro, Kazutaka Jin, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

NMC case report journal　12　65-71　2025年

DOI： 10.2176/jns-nmc.2024-0217 　

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Hippocampectomy is effective for drug-resistant mesial temporal lobe epilepsy with hippocampal sclerosis. However, multiple studies have reported high risks associated with hippocampectomy in patients with mesial temporal lobe epilepsy without hippocampal sclerosis on magnetic resonance imaging and in those with preserved memory function. Verbal memory and language functions are believed to coexist in the same hemisphere. We present a case of left mesial temporal lobe epilepsy with atypical memory function lateralization revealed by super-selective infusion of propofol to the intracranial artery (super-selective Wada test). A 24-year-old right-handed man with drug-resistant focal impaired awareness seizures was diagnosed with left mesial temporal lobe epilepsy without hippocampal sclerosis, but he showed preserved verbal intelligence quotient and memory, suggesting a high risk of severe memory decline after hippocampectomy. We performed super-selective Wada test to the posterior cerebral artery to assess the lateralization of verbal and visual memory separately, and to the middle cerebral artery to assess language function. The results revealed right-sided dominance for both verbal and visual memory, although the language was left-dominant. Hippocampectomy was performed and resulted in freedom from seizures. Memory assessments 1 year postoperatively showed no decline in all subtests. In patients with drug-resistant epilepsy exhibiting atypical neuropsychological profiles, the memory-dominant, and language-dominant hemispheres may not align; detailed evaluations of function lateralization are necessary for tailored treatment.
超選択的Wadaテストによって言語優位半球と言語性記憶の優位半球が異なることが明らかになった内側側頭葉てんかんの1症例

菊地花, 大沢伸一郎, 柿沼一雄, 太田祥子, 勝瀬一登, 浮城一司, 神一敬, 遠藤英徳, 中里信和, 鈴木匡子

てんかん研究　42　(3)　665-666　2025年1月
出版者・発行元： (一社)日本てんかん学会
ISSN：0912-0890

eISSN：1347-5509
Multifactorial Assessment of Complication Risks in Embolization for Ruptured Cerebral Aneurysm

Arata Nagai, Shinya Sonobe, Kuniyasu Niizuma, Tetsuo Ishikawa, Eiryo Kawakami, Yasushi Matsumoto, Hirotoshi Imamura, Tetsu Satow, Koji Iihara, Chiaki Sakai, Nobuyuki Sakai, Shigeru Miyachi, Hidenori Endo, Teiji Tominaga

Journal of Neuroendovascular Therapy　19　(1)　n/a-n/a　2025年
出版者・発行元： The Japanese Society for Neuroendovascular Therapy
DOI： 10.5797/jnet.oa.2024-0095 　

ISSN：1882-4072

eISSN：2186-2494
Fabrication and evaluation of Wrap Around Neural-Pass to record and stimulate neural activity in the cervical spinal cord

Kazushi Tsuji, Atsuhiko Ninomiya, Naoki Iwanuma, Chenxi Qiu, Shutaro Oba, Hisashi Kino, Takafumi Fukushima, Norihiro Katayama, Kuniyasu Niizuma, Hidenori Endo, Tetsu Tanaka

Japanese Journal of Applied Physics　2024年12月2日

DOI： 10.35848/1347-4065/ad9a6f 　
A Case of Acute Epidural Hematoma Caused by Mandibular Fossa Fracture. 国際誌

Takeyoshi Honta, Noboru Takahashi, Toshio Kikuchi, Shunsuke Omodaka, Hidenori Endo

Cureus　16　(12)　e75023　2024年12月

DOI： 10.7759/cureus.75023 　

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Acute epidural hematoma is one of the most serious traumatic conditions in neurosurgery, for which emergency surgery may be indicated. Injury to the middle meningeal artery (MMA) is generally the cause of hemorrhage, often accompanied by convexity fractures resulting from head trauma. However, an epidural hematoma by a contusion of the jaw is very rare. A 27-year-old male fell after drinking alcohol and was brought to our hospital. The patient's Glasgow Coma Scale (GCS) score was 6 (E1V1M4), and the right pupil was 5 mm with no response to light. A computed tomography (CT) scan of the head showed an acute epidural hematoma in the right middle skull base to the temporal region and no fracture lines of the vault of the skull. An emergency right frontotemporal craniotomy was performed to remove the hematoma. A postoperative recheck of the preoperative images revealed a right mandibular fossa fracture. The postoperative course was uneventful, with clear consciousness and resolution of motor paralysis the day after surgery. On the 11th postoperative day, the patient could walk independently and was discharged. As there was no injury to the MMA in the convexity area, which is generally the cause of acute epidural hematoma, damage to a branch of the MMA resulting from a mandibular fossa fracture was considered a possible mechanism for developing acute epidural hematoma. A case of mandibular fossa fracture resulting in acute epidural hematoma is extremely rare, and the etiology remains unknown, so we reported here with a review of the literature.
Recurring utterances induced by local anesthetic administration to the left frontal lobe. 国際誌

Kazuo Kakinuma, Shin-Ichiro Osawa, Hana Kikuchi, Kazuto Katsuse, Makoto Ishida, Kazushi Ukishiro, Kazutaka Jin, Shingo Kayano, Shunji Mugikura, Hidenori Endo, Nobukazu Nakasato, Minoru Matsuda, Kyoko Suzuki

Cortex; a journal devoted to the study of the nervous system and behavior　183　15-20　2024年11月19日

DOI： 10.1016/j.cortex.2024.10.019 　

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Recurring utterances (RUs) are a distinct language symptom observed in severe aphasia, known to be associated with global or Broca's aphasia, though their neural basis remains unclear. We present a case of RU induced by selective left frontal suppression using a novel technique named the super-selective Wada test (ssWada), which involves temporary anesthetization of specific brain regions through super-selective catheterization of cerebral arteries. This method allows for precise simulation of localized brain dysfunction. We applied this technique on a 49-year-old right-handed man with drug-resistant epilepsy as a preoperative examination. Propofol administration to the superior branch of the left middle cerebral artery (MCA), supplying the pars triangularis, pars opercularis, middle frontal gyrus, and part of the precentral gyrus, induced Broca's aphasia with RUs. The RU content was the phrase uttered at anesthesia administration. Notably, the anesthetic did not affect the temporal language area or basal ganglia. The patient showed minimal awareness of his abnormal speech despite preserved receptive language function and memory, aligning with previous observations of anosognosia in patients with RU. Contrastingly, anesthetic infusion into the inferior branch of the left MCA resulted in mixed aphasia, while right MCA infusion induced no language impairments. This case demonstrates that RUs can arise without deficits in the posterior language area or basal ganglia. It illustrates the potential of ssWada in investigating neural substrates of neuropsychological symptoms through temporary, localized brain disruption. This approach offers novel insights into brain-behavior relationships in language processing and cognition.
Residual Pattern of the Hyperintense Area on T2-Weighted Magnetic Resonance Imaging After Initial Treatment Predicts the Pattern and Location of Recurrence in Patients with Newly Diagnosed Glioblastoma. 国際誌

Yoshiteru Shimoda, Masayuki Kanamori, Shota Yamashita, Ichiyo Shibahara, Rei Umezawa, Shunji Mugikura, Keiichi Jingu, Ryuta Saito, Yukihiko Sonoda, Toshihiro Kumabe, Hidenori Endo

World neurosurgery　193　517-532　2024年11月12日

DOI： 10.1016/j.wneu.2024.10.012 　

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OBJECTIVE: This study examined the clinical significance of residual hyperintense area on T2-weighted magnetic resonance imaging (T2R) without gadolinium-enhanced lesions at the end of initial treatment (debulking surgery, concomitant radiotherapy, and temozolomide) in patients with glioblastoma. METHODS: Among 150 glioblastoma cases, 77 cases without enhanced lesions at the end of initial treatment and without factors modifying the distribution of residual hyperintense area or pattern of recurrence were included. We retrospectively reviewed the relationship of residual hyperintense area after initial treatment with progression-free survival (PFS), overall survival (OS), and pattern of recurrence. RESULTS: In these 77 cases, the median PFS and OS were 12.4 and 27.4 months, respectively. At the end of initial treatment, 55 (71.4%) cases had residual hyperintense area (T2 residual group, T2R), whereas 22 (28.6%) showed no hyperintense area (T2 disappeared group, disappeared hyperintense area on T2-weighted magnetic resonance imaging [T2D]). Based on univariate and multivariate analyses, the residual hyperintense area after initial treatment was not a prognostic factor for PFS or OS. Distant recurrences occurred more frequently in the T2D group than in the T2R group 50.0% versus 9.5%. In the T2R group, the recurrence site coincided with the residual hyperintense area in 36 (85.7%) of 42 recurrences. CONCLUSIONS: The T2R at the end of initial treatment can predict local recurrence. However, the distant recurrence occurred frequently in T2D group. Thus, attention should be paid to local recurrences in T2R group and distant recurrences in T2D group.
Efficacy and safety of carmustine wafers, followed by radiation, temozolomide, and bevacizumab therapy, for newly diagnosed glioblastoma with maximal resection.

Masayuki Kanamori, Ichiyo Shibahara, Yoshiteru Shimoda, Yukinori Akiyama, Takaaki Beppu, Shigeo Ohba, Toshiyuki Enomoto, Takahiro Ono, Yuta Mitobe, Mitsuto Hanihara, Yohei Mineharu, Joji Ishida, Kenichiro Asano, Yasuyuki Yoshida, Manabu Natsumeda, Sadahiro Nomura, Tatsuya Abe, Hajime Yonezawa, Ryuichi Katakura, Soichiro Shibui, Toshihiko Kuroiwa, Hiroyoshi Suzuki, Hidehiro Takei, Haruo Matsushita, Ryuta Saito, Yoshiki Arakawa, Yukihiko Sonoda, Yuichi Hirose, Toshihiro Kumabe, Takuhiro Yamaguchi, Hidenori Endo, Teiji Tominaga

International journal of clinical oncology　2024年11月11日

DOI： 10.1007/s10147-024-02650-9 　

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BACKGROUND: To improve the outcome in newly diagnosed glioblastoma patients with maximal resection, we aimed to evaluate the efficacy and safety of implantation of carmustine wafers (CWs), radiation concomitant with temozolomide and bevacizumab, and maintenance chemotherapy with six cycles of temozolomide and bevacizumab. METHOD: This prospective phase II study enrolled glioblastoma patients considered candidates for complete resection (> 90%) of a contrast-enhanced lesion. The CWs were intraoperatively implanted into the resection cavity after achieving maximal resection. Patients without a measurable contrast-enhanced lesion on magnetic resonance imaging within 48 h after resection received concomitant radiotherapy and chemotherapy with temozolomide and bevacizumab, followed by maintenance treatment with up to six cycles of temozolomide and bevacizumab. The primary endpoint was the 2-year overall survival rate in glioblastoma patients with protocol treatment. RESULTS: From October 2015 to April 2018, we obtained consent for the first registration from 70 patients across 17 institutions in Japan, and 49 patients were treated according to the protocol. We evaluated the safety in 49 patients who were part of the second registration and the efficacy in 45 glioblastoma patients treated according to the protocol. The profile of hematological and most of the non-hematological adverse effects was similar to that in previous studies, but stroke occurred in 12% of cases (6/49 patients). The estimated 2-year overall survival rate was 51.3%. CONCLUSION: Implantation of CWs, followed by concomitant radiation, temozolomide, and bevacizumab, and six cycles of temozolomide and bevacizumab may offer some benefit to survival in Japanese glioblastoma patients with maximal resection. TRIAL ID: jRCTs021180007.
小児・AYA世代脳腫瘍治療の最前線を知る小児・AYA世代脳腫瘍に対する外科治療

隈部俊宏, 柴原一陽, 金森政之, 齋藤竜太, 園田順彦, 遠藤英徳

日本小児血液・がん学会雑誌　61　(3)　238-244　2024年11月
出版者・発行元： (一社)日本小児血液・がん学会
ISSN：2187-011X

eISSN：2189-5384
もやもや病高齢者もやもや病の病態と血行再建術

鹿毛淳史, 内田浩喜, 田代亮介, 坂田洋之, 新妻邦泰, 遠藤英徳

脳循環代謝　36　(1)　68-68　2024年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN：0915-9401

eISSN：2188-7519
フローダイバーター治療戦略のパラダイムシフト DSAを用いた脳循環解析による術中動脈瘤閉塞予測

坂田洋之, 針生新也, 田代亮介, 鹿毛浩喜, 遠藤英徳

脳循環代謝　36　(1)　80-80　2024年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN：0915-9401

eISSN：2188-7519
頸動脈ステント留置術後過灌流予防のためのエダラボン術前投与

井上敬, 大友智, 庄司薫, 佐藤健一, 坂田洋之, 遠藤英徳

脳循環代謝　36　(1)　107-107　2024年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN：0915-9401

eISSN：2188-7519
臨床医がAI技術を理解する意義

園部真也, 新妻邦泰, 永井新, 竹内洋平, 田宮元, 岩崎淳也, 宮内誠, 小林智哉, 高屋英知, 川上英良, 石川哲朗, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　40回　1064-1064　2024年11月
出版者・発行元： (一社)日本脳神経血管内治療学会
eISSN：2759-6907
麻酔薬の頭蓋内選択的動注と認知神経学的評価を融合した任意脳領域の機能局在診断法

大沢伸一郎, 鈴木匡子, 柿沼一雄, 勝瀬一登, 浮城一司, 金森政之, 下田由輝, 新妻邦泰, 松本康史, 神一敬, 中里信和, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　40回　330-330　2024年11月
出版者・発行元： (一社)日本脳神経血管内治療学会
eISSN：2759-6907
【虚血性脳血管障害】頭蓋内脳動脈狭窄症の血管内治療

坂田洋之, 針生新也, 佐藤健一, 江面正幸, 矢澤由加子, 面高俊介, 鹿毛淳史, 内田浩喜, 遠藤英徳

脳神経外科ジャーナル　33　(11)　764-769　2024年11月
出版者・発行元： (一社)日本脳神経外科コングレス
ISSN：0917-950X

eISSN：2187-3100
Type 2 diabetes remodels collateral circulation and promotes leukocyte adhesion following ischemic stroke. 国際誌

Yoshimichi Sato, Yuandong Li, Yuya Kato, Atsushi Kanoke, Jennifer Y Sun, Yasuo Nishijima, Ruikang K Wang, Michael Stryker, Hidenori Endo, Jialing Liu

bioRxiv : the preprint server for biology　2024年10月23日

DOI： 10.1101/2024.10.23.619748 　

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Type 2 diabetes mellitus (T2DM) is associated with impaired leptomeningeal collateral compensation and poor stroke outcome. Neutrophils tethering and rolling on endothelium after stroke can also independently reduce flow velocity. However, the chronology and topological changes in collateral circulation in T2DM is not yet defined. Here, we describe the spatial and temporal blood flow dynamics and vessel remodeling in pial arteries and veins and leukocyte-endothelial adhesion following middle cerebral artery (MCA) stroke using two-photon microscopy in awake control and T2DM mice. Relative to control mice prior to stroke, T2DM mice already exhibited smaller pial vessels with reduced flow velocity. Following stroke, T2DM mice displayed persistently reduced blood flow in pial arteries and veins, resulting in a poor recovery of downstream penetrating arterial flow and a sustained deficit in microvascular flow. There was also persistent increase of leukocyte adhesion to the endothelium of veins, coincided with elevated neutrophils infiltration into brain parenchyma in T2DM mice compared to control mice after stroke. Our data suggest that T2DM-induced increase in chronic inflammation may contribute to the remodeling of leptomeningeal collateral circulation and the observed hemodynamics deficiency that potentiates poor stroke outcome.
Intravenous administration of muse cells improves cerebral ischemia outcome via immunomodulation in the spleen. 国際誌

Yuya Kato, Daiki Aburakawa, Ryosuke Tashiro, Yuan Zhou, Sherif Rashad, Hidenori Endo, Teiji Tominaga, Kuniyasu Niizuma

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism　271678X241290363　2024年10月13日

DOI： 10.1177/0271678X241290363 　

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Ischemic stroke is a leading cause of disability and death globally. Stem cell therapies are emerging as a frontier for enhancing post-stroke recovery, with Muse cells-a subclass of pluripotent stem cells-demonstrating considerable promise. Muse cells are notable not only for their potential in cell replacement but also for their role in modulating immune responses following cerebral infarction. In the present study, we administered Muse cells intravenously to mice after inducing a stroke via distal middle cerebral artery occlusion. We evaluated motor outcomes, splenocyte populations, cytokine profiles, and gene expression 2 weeks after inducing stroke. Additionally, comparisons were drawn between outcomes in splenectomized mice and those receiving adoptive splenocyte transfer to discern the specific influence of the spleen on treatment efficacy. Our findings revealed that Muse cell therapy facilitates motor recovery, an effect that is compromised in the absence of the spleen. Spleens in treated mice exhibited a shift in neutrophil counts, increased cytokine activity, and a notable uptick in the expression of genes related to protein folding. These insights affirm the potential therapeutic effect of Muse cells in post-stroke treatment strategies, with their efficacy attributed, at least in part, to immunomodulatory pathways involving the spleen.
CHA2DS2-VASc score and prior oral anticoagulant use on endovascular treatment for acute ischemic stroke. 国際誌

Yukihiro Imaoka, Nice Ren, Soshiro Ogata, Hirotoshi Imamura, Yasuyuki Kaku, Koichi Arimura, Shogo Watanabe, Eri Kiyoshige, Kunihiro Nishimura, Syoji Kobashi, Masafumi Ihara, Kenji Kamiyama, Masafumi Morimoto, Tsuyoshi Ohta, Hidenori Endo, Yuji Matsumaru, Nobuyuki Sakai, Takanari Kitazono, Shigeru Fujimoto, Kuniaki Ogasawara, Koji Iihara

Annals of clinical and translational neurology　2024年10月9日

DOI： 10.1002/acn3.52217 　

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OBJECTIVE: We evaluated the effect of CHA2DS2-VASc score and prior use of oral anticoagulants (OACs) on endovascular treatment (EVT) in patients with acute ischemic stroke and atrial fibrillation (AF). METHODS: Patients with AF who received EVT in 353 centers in Japan (2018-2020) were included. The outcomes were symptomatic intracerebral hemorrhage (sICH), in-hospital mortality, functional independence, and successful and complete reperfusion. The effects of CHA2DS2-VASc score, its components, and prior use of OACs were assessed via a multiple logistic regression model. RESULTS: Of the 6984 patients, 780 (11.2%) used warfarin and 1168 (16.7%) used direct oral anticoagulants (DOACs) before EVT. Based on the CHA2DS2-VASc score, 6046 (86.6%) presented a high risk (≥2 for males and ≥3 for females) while 938 (13.4%) had intermediate to low risks. Higher CHA2DS2-VASc scores were associated with increased sICH, in-hospital mortality, and decreased functional independence, regardless of prior OACs. For patients with a high-risk category, prior DOACs increased the odds of successful and complete reperfusion (adjusted odds ratio [95% confidence interval (CI)], 1.27 [1.00-1.61] and 1.30 [1.10-1.53]). For those with integrated intermediate to low risks, neither prior warfarin nor DOAC affected the outcomes. Regardless of total CHA2DS2-VASc scores, patients with congestive heart failure or left ventricular dysfunction, hypertension, age >75 years, or female benefited similarly from prior DOAC use. INTERPRETATION: Prior DOAC use for patients with high- and selected intermediate-risk CHA2DS2-VASc scores increased prevalence of successful and complete reperfusion. These findings may provide supplemental evidence to introduce preventive DOAC for patients with AF.
左側頭葉新皮質病変を伴うてんかんにおける発作時心拍上昇率の比較

高野歩有, 浮城一司, 曽我天馬, 神一敬, 板橋泉, 大沢伸一郎, 岩崎真樹, 遠藤英徳, 中里信和

臨床神経生理学　52　(5)　622-622　2024年10月
出版者・発行元： (一社)日本臨床神経生理学会
ISSN：1345-7101

eISSN：2188-031X
Spatiotemporal neural dynamics in kanji vs. kana reading: An electroencephalography(ECoG) study(タイトル和訳中)

Katsuse Kazuto, Kakinuma Kazuo, Osawa Shinichiro, Ota Shoko, Kikuchi Hana, Kawamura Ai, Ukishiro Kazushi, Tanji Kazuyo, Iseki Chifumi, Kanno Shigenori, Hamada Masashi, Toda Tatsushi, Endo Hidenori, Nakasato Nobukazu, Suzuki Kyoko

臨床神経学　64　(Suppl.)　S237-S237　2024年10月
出版者・発行元： (一社)日本神経学会
ISSN：0009-918X

eISSN：1882-0654
Clinical significance of cerebral microbleeds in patients with germinoma who underwent long-term follow-up. 国際誌

Masayuki Kanamori, Shunji Mugikura, Osamu Iizuka, Naoko Mori, Yoshiteru Shimoda, Ichiyo Shibahara, Rei Umezawa, Keiichi Jingu, Ryuta Saito, Yukihiko Sonoda, Toshihiro Kumabe, Kyoko Suzuki, Hidenori Endo

Journal of neuro-oncology　170　(1)　173-184　2024年10月

DOI： 10.1007/s11060-024-04753-9 　

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PURPOSE: This study identified the factors affecting cerebral microbleed (CMBs) development. Moreover, their effects on intelligence and memory and association with stroke in patients with germinoma who had long-term follow-up were evaluated. METHODS: This study included 64 patients with germinoma who were histologically and clinically diagnosed with and treated for germinoma. These patients were evaluated cross-sectionally, with a focus on CMBs on susceptibility-weighted magnetic resonance imaging (SWI), brain atrophy assessed through volumetric analysis, and intelligence and memory. RESULTS: The follow-up period was from 32 to 412 (median: 175.5) months. In total, 43 (67%) patients had 509 CMBs and 21 did not have CMBs. Moderate correlations were observed between the number of CMBs and time from initial treatments and recurrence was found to be a risk factor for CMB development. Increased temporal CMBs had a marginal effect on the processing speed and visual memory, whereas brain atrophy had a statistically significant effect on verbal, visual, and general memory and a marginal effect on processing speed. Before SWI acquisition and during the follow-up periods, eight strokes occurred in four patients. All of these patients had ≥ 15 CMBs on SWI before stroke onset. Meanwhile, 33 patients with < 14 CMBs or 21 patients without CMBs did not experience stroke. CONCLUSION: Patients with a longer time from treatment initiation had a higher number of CMBs, and recurrence was a significant risk factor for CMB development. Furthermore, brain atrophy had a stronger effect on memory than CMBs. Increased CMBs predict the stroke onset.
Levodopa-resistant parkinsonism developing after ventriculoperitoneal shunting for obstructive hydrocephalus and improving after endoscopic third ventriculostomy, with specific consideration of brainstem morphology: illustrative case. 国際誌

Yoshihiko Morisue, Shin-Ichiro Osawa, Kuniyasu Niizuma, Shigenori Kanno, Kyoko Suzuki, Hidenori Endo

Journal of neurosurgery. Case lessons　8　(11)　2024年9月9日

DOI： 10.3171/CASE2429 　

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BACKGROUND: Parkinsonism has been reported in patients with obstructive hydrocephalus (OH) following ventriculoperitoneal shunting (VPS). While levodopa works well, some cases are drug resistant. A few case series have reported that endoscopic third ventriculostomy (ETV) is beneficial, though its mechanism remains unclear. The use of a pathophysiology-reflected marker can aid in the diagnosis and treatment strategy. The authors report a case of parkinsonism due to OH after VPS that improved after ETV in a patient taking levodopa, which was subsequently discontinued. OBSERVATIONS: A 52-year-old man who had undergone VPS for OH caused by aqueductal stenosis with a tectal tumor presented with severe consciousness disturbance due to acute hydrocephalus and levodopa-refractory parkinsonism after multiple episodes of shunt malfunction. Magnetic resonance imaging showed an elevation of the floor of the third ventricle. ETV was performed to stabilize the pressure imbalance across the stenosis, and his parkinsonism symptoms improved after long-term rehabilitation, resulting in levodopa discontinuation. His pontomesencephalic angle, the angle between the anterior surface of the midbrain and upper surface of the pons in the midline of the sagittal plane, was significantly decreased. LESSONS: The focus in such cases should be on the essence of the pathophysiology for improving the symptoms rather than on easy-to-understand indicators such as ventricle size. https://thejns.org/doi/10.3171/CASE2429.
Concurrent delayed recurrence of peripheral primitive neuroectodermal tumors in orbital and sellar/suprasellar regions in an older adult. 国際誌

Shota Yamashita, Michiko Yokosawa, Sadahide Ono, Takayuki Sugawara, Naoto Kimura, Hidenori Endo

European journal of ophthalmology　11206721241277251-11206721241277251　2024年9月3日

DOI： 10.1177/11206721241277251 　

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BACKGROUND: Peripheral primitive neuroectodermal tumors (pPNETs) are rare and aggressive small round cell tumors, tending to occur in the thoracic and paravertebral soft tissues in children and young adults. This report describes an exceptionally rare case of concurrent delayed recurrence of pPNET in the orbital and sellar/suprasellar regions in an older adult, with a discussion supported by a literature review. CASE PRESENTATION: We report an 82-year-old woman with a history of orbital pPNETs resection at age 62, followed by gamma knife radiosurgery for local recurrence at age 66. She presented left eye pain, left eye protrusion, decreased vision in the right eye, and right homonymous hemianopia. MRI revealed extensive lesions in the left orbital cavity and sellar/suprasellar region, contiguous through the optic canal. The recurrent tumor was treated through a two-stage resection via transcranial and transsphenoidal approaches, which resulted in symptom improvement and a pathologic diagnosis of pPNETs. CONCLUSION: This case highlights a highly rare instance of late-onset orbital pPNETs recurrence in an elderly patient, with evidence suggesting tumor progression into the sellar/suprasellar regions through the optic canal.
Vestibular paroxysmia caused by a subarcuate artery: illustrative case 国際誌

Kensuke Sakaji, Shunsuke Omodaka, Masayuki Kanamori, Shunsuke Takai, Akari Sawada, Jun Suzuki, Yukio Katori, Hidenori Endo

Journal of Neurosurgery: Case Lessons　8　(10)　2024年9月2日
出版者・発行元： Journal of Neurosurgery Publishing Group (JNSPG)
DOI： 10.3171/case24239 　

eISSN：2694-1902

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BACKGROUND Vestibular paroxysmia is defined by spontaneous, recurrent, short, paroxysmal episodes of vertigo. The authors present a case of vestibular paroxysmia caused by neurovascular compression of the vestibulocochlear nerve due to the subarcuate artery, which was successfully treated with microvascular decompression. OBSERVATIONS A 46-year-old man ﬁrst experienced vertigo attacks 5 years earlier. The attacks became more frequent, and left-sided tinnitus developed over the past 4 months, prompting a referral to our hospital. Carbamazepine treatment alleviated symptoms but had to be discontinued due to rash. Brain magnetic resonance imaging and angiography revealed that the left anterior inferior cerebellar artery was pressing on the cisternal segment of the left vestibulocochlear nerve. The authors diagnosed vestibular paroxysmia caused by neurovascular compression and performed microvascular decompression. During the operation, a subarcuate artery was identified as the offending vessel, with a prominent indentation on the vestibulocochlear nerve. The vertigo was completely relieved following surgery. LESSONS Neurovascular compression of the vestibulocochlear nerve by the subarcuate artery can result in vestibular paroxysmia. https://thejns.org/doi/abs/10.3171/CASE24239
【くも膜下出血のニューフロンティア-病態の再考と治療の進化】破裂脳動脈瘤の病態-脳動脈瘤はなぜ破裂するのか? 脳動脈瘤に関する画像診断の最新事情

面高俊介, 遠藤英徳

Neurological Surgery　52　(5)　938-944　2024年9月
出版者・発行元： (株)医学書院
ISSN：0301-2603

eISSN：1882-1251
脳内血腫を合併した重症くも膜下出血に対するクラゾセンタンの使用経験

本多赳善, 面高俊介, 岩本憲宏, 佐藤加奈子, 成田徳雄, 遠藤英徳

脳卒中の外科　52　(5)　375-381　2024年9月
出版者・発行元： (一社)日本脳卒中の外科学会
ISSN：0914-5508

eISSN：1880-4683
てんかん発作症候学ビデオケースセッション脳外科・救急領域でみる心因性非てんかん発作

大沢伸一郎, 岩城弘隆, 小川舞美, 中里信和, 遠藤英徳

てんかん研究　42　(2)　315-315　2024年9月
出版者・発行元： (一社)日本てんかん学会
ISSN：0912-0890

eISSN：1347-5509
超選択的Wadaテストで言語優位半球と言語性記銘力の側方性不一致が示された側頭葉てんかんの1例

柿沼一雄, 大沢伸一郎, 菊地花, 太田祥子, 勝瀬一登, 土屋真理夫, 浮城一司, 神一敬, 遠藤英徳, 中里信和, 鈴木匡子

神経心理学　40　(3)　231-241　2024年9月
出版者・発行元：日本神経心理学会
ISSN：0911-1085

eISSN：2189-9401
後大脳動脈で灌流される海馬周囲構造への超選択的麻酔は記憶機能のモダリティ別評価を可能にする

大沢伸一郎, 鈴木匡子, 柿沼一雄, 勝瀬一登, 菊地花, 浮城一司, 石田誠, 下田由輝, 新妻邦泰, 神一敬, 中里信和, 遠藤英徳

てんかん研究　42　(2)　514-514　2024年9月
出版者・発行元： (一社)日本てんかん学会
ISSN：0912-0890

eISSN：1347-5509
超選択的Wadaテストによる脳領域別の言語機能推定

柿沼一雄, 大沢伸一郎, 勝瀬一登, 菊地花, 太田祥子, 川村藍, 劉軍艶, 浮城一司, 神一敬, 遠藤英徳, 中里信和, 鈴木匡子

てんかん研究　42　(2)　521-521　2024年9月
出版者・発行元： (一社)日本てんかん学会
ISSN：0912-0890

eISSN：1347-5509
Wadaテストにおける記憶スコアは言語機能領域への薬剤注入で低下しうる

菊地花, 大沢伸一郎, 柿沼一雄, 勝瀬一登, 太田祥子, 川村藍, 劉軍艶, 浮城一司, 神一敬, 遠藤英徳, 中里信和, 鈴木匡子

てんかん研究　42　(2)　522-522　2024年9月
出版者・発行元： (一社)日本てんかん学会
ISSN：0912-0890

eISSN：1347-5509
Persistent Depression of the Lambda Site with Progressive Skull Deformity May Be a Sign of Suture Closure: Case Series and Pathologic Consideration. 国際誌

Tomohito Nagai, Toshiaki Hayashi, Tomomi Kimiwada, Madoka Inukai, Junji Takeyama, Yoshihisa Shimanuki, Masahiro Kitami, Takehiko Sanada, Hidenori Endo

World neurosurgery　189　e725-e731　2024年9月

DOI： 10.1016/j.wneu.2024.06.154 　

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BACKGROUND: Flat head syndrome (FHS) sometimes occurs when a baby maintains the same head position during the first several months of life, causing a skull deformity. FHS usually improves with time and natural growth, although some show aggravation against conservative treatment. We reviewed pathologically proved early closure of skull suture that may be seen secondary to FHS. METHODS: The clinical and radiologic findings of the patients who showed progressive skull deformity resembling FHS were retrospectively reviewed. All the patients underwent surgical treatment and pathologic specimens were obtained. RESULTS: The detected patients included two 5-month-old infants and one 1-year-old child. The former were conservatively treated without any obvious premature suture closure on computed tomography (CT), and later developed progressive tower-like skull deformities. The infants were diagnosed with possible premature fusion of lambda site and underwent removal around lambda depression (LD). The latter showed evident sagittal suture closure on CT with digital markings, and was diagnosed with increased intracranial pressure and underwent cranioplasty of posterior expansion. Histopathologic specimens obtained from the patients' resected sutures showed irregularly narrowed suture structure with ossification and fibrous tissue proliferation within them, supporting the diagnosis of premature closure of the sagittal sutures. Their postoperative courses were uneventful, and their skull deformities subsequently improved. CONCLUSIONS: Conservative therapy-resistant progressive occipital skull deformity with LD may be a sign of early suture closure, even if CT does not show obvious suture closure. The findings are helpful for early diagnosis and might lead to minimal invasive surgery if needed.
[Postoperative Management of Aneurysmal Subarachnoid Hemorrhage].

Hiroyuki Sakata, Hidenori Endo

No shinkei geka. Neurological surgery　52　(5)　906-913　2024年9月

DOI： 10.11477/mf.1436204998 　

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Delayed cerebral ischemia(DCI) is one of the most significant complications of subarachnoid hemorrhage. Despite significant evolution in understanding DCI pathophysiology, vasospasm affecting cerebral vessels of large and moderate diameters remain the only clinically measurable component of DCI and is therefore the primary target for intervention in the postoperative management of subarachnoid hemorrhage. In Japan, fasudil hydrochloride and ozagrel sodium are widely used to prevent vasospasms; however, their effects are sometimes insufficient. Clazosentan, a selective endothelin receptor subtype A antagonist, reduces vasospasm-related morbidity and all-cause mortality following aneurysmal subarachnoid hemorrhage. This was demonstrated in a recent randomized phase 3 trial, leading to the approval of clazosentan by the Pharmaceuticals and Medical Devices Agency in Japan. Recent advances in our understanding of subarachnoid hemorrhage will facilitate improved management to reduce the incidence of DCI.
[Update on Vessel Wall Imaging of Intracranial Aneurysm].

Shunsuke Omodaka, Hidenori Endo

No shinkei geka. Neurological surgery　52　(5)　938-944　2024年9月

DOI： 10.11477/mf.1436205003 　

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Intracranial aneurysms occur frequently; however, only a few of these rupture to cause subarachnoid hemorrhage. This presents a dilemma regarding the course of appropriate treatment. In the last decade, the wide utilization of magnetic resonance imaging-based vessel wall imaging(VWI) has facilitated the assessment of aneurysm wall enhancement(AWE), which has garnered significant attention. In 2013, initial reports highlighted that AWE was characteristic of ruptured aneurysms whereas, in 2014, AWE was identified as a characteristic feature of unruptured aneurysms with a high risk of rupture. Several studies have supported these findings since then. VWI, a novel modality that visualizes the inflammation of the aneurysmal wall, is considered highly useful for the diagnosis of aneurysms. This review discusses the key literature on AWE. Long-term prospective studies are warranted to determine whether AWE is an independent risk factor for aneurysmal progression.
Aneurysm Wall Enhancement Can Predict Rupture Point in Intracranial Aneurysms With Multiple Blebs. 国際誌

Shunsuke Omodaka, Shin-Ichiro Sugiyama, Hiroyuki Sakata, Kenichi Funamoto, Takuhiro Yamaguchi, Kuniyasu Niizuma, Hidenori Endo

Neurosurgery　2024年8月8日

DOI： 10.1227/neu.0000000000003134 　

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BACKGROUND AND OBJECTIVES: Ruptured aneurysms visualized by vessel wall MRI (VW-MRI) exhibit characteristic aneurysm wall enhancement (AWE). A secondary bulge of the aneurysmal wall, called a bleb, is often the site of rupture in ruptured aneurysms. We hypothesized that a higher degree of AWE would identify the rupture point in aneurysms with multiple blebs. METHODS: AWE was quantitatively analyzed in consecutive ruptured intracranial aneurysms with multiple blebs (31 aneurysms with a total of 72 blebs) using VW-MRI. A 3-dimensional T1-weighted fast spin-echo sequence was obtained after contrast media injection, and the contrast ratio of the aneurysm wall against the pituitary stalk (CRstalk) was calculated as the AWE indicator. Bleb characteristics, including CRstalk and wall shear stress (WSS), were compared between ruptured and unruptured blebs. Odds ratios with 95% confidence intervals for ruptures were calculated by conditional logistic regression analysis. RESULTS: Ruptured blebs had a higher CRstalk and lower WSS compared with unruptured blebs. CRstalk remained significantly associated with the bleb rupture status in the conditional logistic regression (adjusted odds ratio 3.9, 95% CIs 1.6-9.7). CONCLUSION: AWE is associated with the bleb rupture status independent of WSS. Contrast-enhanced VW-MRI may be a useful noninvasive tool for identifying the rupture point and guiding the treatment strategy.
右大脳半球への超選択的Wadaテストによる半側空間無視の評価法の開発

勝瀬一登, 柿沼一雄, 大沢伸一郎, 浮城一司, 菊地花, 川村藍, 齋藤治仁, 太田祥子, 伊関千書, 菅野重範, 戸田達史, 遠藤英徳, 中里信和, 鈴木匡子

日本神経心理学会総会プログラム・予稿集　48回　104-104　2024年8月
出版者・発行元：日本神経心理学会
No unfavorable effects on the menstruation recovery of early postoperative hypoprolactinemia after transsphenoidal surgery in patients with lactotroph pituitary neuroendocrine tumor. 国際誌

Tomohisa Ishida, Tomohiro Kawaguchi, Yoshikazu Ogawa, Teiji Tominaga, Hidenori Endo

BMC research notes　17　(1)　212-212　2024年7月30日

DOI： 10.1186/s13104-024-06866-w 　

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OBJECTIVE: Transsphenoidal surgery for lactotroph pituitary neuroendocrine tumor (PitNET) lowers serum prolactin concentrations, occasionally below the normal range. However, the clinical significance of postoperative hypoprolactinemia is still unclear. In this study, we retrospectively reviewed the female patients with lactotroph PitNET who were treated with transsphenoidal surgery to elucidate the influence of postoperative hypoprolactinemia on regular menstruation restoration and endocrinological remission. RESULTS: The serum prolactin levels in all thirty three participating females had decreased following surgery. Serum prolactin levels in seven patients had decreased below the lower limit of normal ranges (hypoproactinemia group) and in the remaining twenty six patients, it was within the normal range (non-hypoproractinemia group). In hypoprolactinemia group, regular menstruation was restored in all patients with only lactotroph axis deficiency. Nine patients from the non-hypoprolactinemia group experienced re-elevation of serum prolactin concentration (27%). No patient in hypoprolactinemia group experienced the relapse of hyperprolactinemia. These data suggest that early postoperative hypoprolactinemia after transsphenoidal surgery for lactotroph PitNET is not only a good predictive factor for endocrinological remission but also no unfavorable effects on regular menstruation restoration.
Complete Corpus Callosotomy Brings Worthwhile Seizure Reduction in Both Pediatric and Adult Patients. 国際誌

Kazushi Ukishiro, Shin-Ichiro Osawa, Masaki Iwasaki, Yosuke Kakisaka, Kazutaka Jin, Mitsugu Uematsu, Tetsuya Yamamoto, Teiji Tominaga, Hidenori Endo, Nobukazu Nakasato

Neurosurgery　2024年7月2日

DOI： 10.1227/neu.0000000000003092 　

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BACKGROUND AND OBJECTIVES: The influence of the age at which complete corpus callosotomy (CC) surgery is performed on seizure outcomes remains unclear. This study aimed to evaluate the age-dependent aspects of long-term seizure outcomes after complete CC. METHODS: We reviewed 41 patients who underwent one-stage complete CC. Seizure outcomes were analyzed for age at epilepsy onset and at complete CC, focal MRI abnormality, and etiology. RESULTS: The median age was 7 months at epilepsy onset and 93 months at complete CC. The median follow-up duration was 67 months. Sixteen patients had focal MRI lesions and 4 had only general atrophy. Etiology was identified in 20 patients. For overall seizure outcomes (N = 41), complete seizure freedom was achieved in 5 patients, excellent seizure reduction (>80%) in 11, good (50%-80%) in 5, and poor (<50%) in 20. Freedom was correlated with younger age at complete CC and unknown etiology (P ≤ .05). Freedom was only achieved in patients aged younger than 7 years. Worthwhile (≥50%, freedom, excellent, and good) and not worthwhile (<50%, poor) overall seizure reduction showed no statistical difference in age at complete CC. No related factor was found for worthwhile overall seizure reduction. For drop attack outcomes (N = 31), freedom was achieved in 22 cases, excellent in 5, and poor in 4. Freedom was correlated with younger age at complete CC (P < .05) although freedom was achieved in 4 of 7 patients older than 20 years. Age at complete CC showed no statistical difference between worthwhile (≥50%) and not worthwhile (<50%) drop attack reduction. Worthwhile drop attack reduction was correlated with unknown etiology (P < .05). Complications were mild and transient. CONCLUSION: Complete CC is an excellent surgical option based on favorable seizure outcomes and acceptable complications in our present study.
Clinical and molecular features of patients with IDH1 wild-type primary glioblastoma presenting unexpected short-term survival after gross total resection 国際誌

Mariko Toyoda, Ichiyo Shibahara, Ryota Shigeeda, Kazuko Fujitani, Yoko Tanihata, Yuri Hyakutake, Hajime Handa, Hideto Komai, Sumito Sato, Madoka Inukai, Takuichiro Hide, Yoshiteru Shimoda, Masayuki Kanamori, Hidenori Endo, Ryuta Saito, Ken-Ichiro Matsuda, Yukihiko Sonoda, Toshihiro Kumabe

Journal of Neuro-Oncology　169　(1)　39-50　2024年6月5日
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1007/s11060-024-04687-2 　

ISSN：0167-594X

eISSN：1573-7373

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BACKGROUND: This study investigated the factors influencing short-term survivors (STS) after gross total resection (GTR) in patients with IDH1 wild-type primary glioblastoma. METHODS: We analyzed five independent cohorts who underwent GTR, including 83 patients from Kitasato University (K-cohort), and four validation cohorts of 148 patients from co-investigators (V-cohort), 66 patients from the Kansai Molecular Diagnosis Network for the Central Nervous System tumors, 109 patients from the Cancer Genome Atlas, and 40 patients from the Glioma Longitudinal AnalySiS. The study defined STS as those who had an overall survival ≤ 12 months after GTR with subsequent radiation therapy, and concurrent and adjuvant temozolomide (TMZ). RESULTS: The study included 446 patients with glioblastoma. All cohorts experienced unexpected STS after GTR, with a range of 15.0-23.9% of the cases. Molecular profiling revealed no significant difference in major genetic alterations between the STS and non-STS groups, including MGMT, TERT, EGFR, PTEN, and CDKN2A. Clinically, the STS group had a higher incidence of non-local recurrence early in their treatment course, with 60.0% of non-local recurrence in the K-cohort and 43.5% in the V-cohort. CONCLUSIONS: The study revealed that unexpected STS after GTR in patients with glioblastoma is not uncommon and such tumors tend to present early non-local recurrence. Interestingly, we did not find any significant genetic alterations in the STS group, indicating that such major alterations are characteristics of GB rather than being reliable predictors for recurrence patterns or development of unexpected STS.
Defective interferon signaling in the circulating monocytes of type 2 diabetic mice. 国際誌

Shunsuke Omodaka, Yuya Kato, Yoshimichi Sato, Jaime Falcone-Juengert, Hongxia Zhang, Atsushi Kanoke, Walter L Eckalbar, Hidenori Endo, Christine L Hsieh, Dvir Aran, Jialing Liu

bioRxiv : the preprint server for biology　2024年6月3日

DOI： 10.1101/2024.06.03.597050 　

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UNLABELLED: Type 2 diabetes mellitus (T2DM) is associated with poor outcome after stroke. Peripheral monocytes play a critical role in the secondary injury and recovery of damaged brain tissue after stroke, but the underlying mechanisms are largely unclear. To investigate transcriptome changes and molecular networks across monocyte subsets in response to T2DM and stroke, we performed single-cell RNA-sequencing (scRNAseq) from peripheral blood mononuclear cells and bulk RNA-sequencing from blood monocytes from four groups of adult mice, consisting of T2DM model db/db and normoglycemic control db/+ mice with or without ischemic stroke. Via scRNAseq we found that T2DM expands the monocyte population at the expense of lymphocytes, which was validated by flow cytometry. Among the monocytes, T2DM also disproportionally increased the inflammatory subsets with Ly6C+ and negative MHC class II expression (MO.6C+II-). Conversely, monocytes from control mice without stroke are enriched with steady-state classical monocyte subset of MO.6C+II+ but with the least percentage of MO.6C+II- subtype. Apart from enhancing inflammation and coagulation, enrichment analysis from both scRNAseq and bulk RNAseq revealed that T2DM specifically suppressed type-1 and type-2 interferon signaling pathways crucial for antigen presentation and the induction of ischemia tolerance. Preconditioning by lipopolysaccharide conferred neuroprotection against ischemic brain injury in db/+ but not in db/db mice and coincided with a lesser induction of brain Interferon-regulatory-factor-3 in the brains of the latter mice. Our results suggest that the increased diversity and altered transcriptome in the monocytes of T2DM mice underlie the worse stroke outcome by exacerbating secondary injury and potentiating stroke-induced immunosuppression. SIGNIFICANCE STATEMENT: The mechanisms involved in the detrimental diabetic effect on stroke are largely unclear. We show here, for the first time, that peripheral monocytes have disproportionally altered the subsets and changed transcriptome under diabetes and/or stroke conditions. Moreover, genes in the IFN-related signaling pathways are suppressed in the diabetic monocytes, which underscores the immunosuppression and impaired ischemic tolerance under the T2DM condition. Our data raise a possibility that malfunctioned monocytes may systemically and focally affect the host, leading to the poor outcome of diabetes in the setting of stroke. The results yield important clues to molecular mechanisms involved in the detrimental diabetic effect on stroke outcome.
Super-selective injection of propofol into the intracranial arteries enables Patient's self-evaluation of expected neurological deficit. 国際誌

Shin-Ichiro Osawa, Kyoko Suzuki, Kazushi Ukishiro, Kazuo Kakinuma, Makoto Ishida, Kuniyasu Niizuma, Yoshiteru Shimoda, Hana Kikuchi, Ryuzaburo Kochi, Kazutaka Jin, Yasushi Matsumoto, Mitsugu Uematsu, Nobukazu Nakasato, Hidenori Endo, Teiji Tominaga

Cortex; a journal devoted to the study of the nervous system and behavior　176　209-220　2024年5月19日

DOI： 10.1016/j.cortex.2024.04.016 　

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INTRODUCTION: It is hard to realize the extent of the expected postoperative neurological deficit for patients themselves. The provision of appropriate information can contribute not only to examining surgical indications but also to filling the gap between patient and expert expectations. We hypothesized that propofol infusion into the intracranial arteries (ssWada) could induce focal neurological symptoms with preserved wakefulness, enabling the patients to evaluate the postsurgical risk subjectively. METHODS: Presurgical evaluation using ssWada was performed in 28 patients with drug-resistant epilepsy. Based on anatomical knowledge, propofol was super-selectively infused into the intracranial arteries including the M1, M2, and M3 segments of the middle cerebral artery (MCA), A2 segment of the anterior cerebral artery, and P2 segment of the posterior cerebral artery to evaluate the neurological and cognitive symptoms. We retrospectively analyzed a total of 107 infusion trials, including their target vessels, and elicited symptoms of motor weakness, sensory disturbance, language, unilateral hemispatial neglect (UHN), and hemianopsia. We evaluated preserved wakefulness which enabled subjective evaluations of the symptoms and comparison of the subjective experience to the objective findings, besides adverse effects during the procedure. RESULTS: Preserved wakefulness was found in 97.2% of all trials. Changes in neurological symptoms were positively evaluated for motor weakness in 51.4%, sensory disturbance in 5.6%, language in 48.6%, UHN in 22.4%, and hemianopsia in 32.7%. Six trials elicited seizures. Multivariate analysis showed significant correlations between symptom and infusion site of language and left side, language and MCA branches, motor weakness and A2 or M2 superior division, and hemianopsia and P2. Transient adverse effect was observed in 8 cases with 12 infusion trials (11.2 %). CONCLUSION: The ssWada could elicit focal neurological symptoms with preserved wakefulness. The methodology enables specific evaluation of risk for cortical resection and subjective evaluation of the expected outcome by the patients.
Remission of startle epilepsy provoked by acoustic stimuli following complete callosotomy: A case study 国際誌

Kazushi Ukishiro, Shin‐ichiro Osawa, Yosuke Kakisaka, Kazutaka Jin, Teiji Tominaga, Hidenori Endo, Nobukazu Nakasato

Epileptic Disorders　26　(4)　510-513　2024年5月7日

DOI： 10.1002/epd2.20238 　

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Herein, we present the case of a 21-year-old man with a history of generalized tonic seizures since the age of 4 years. These seizures occurred either spontaneously or could be provoked by auditory stimuli such as the sounds of a vacuum cleaner or an electric shaver. Despite trials with 10 different anti-seizure medications, his seizures remained refractory. Interictal electroencephalography (EEG) revealed generalized epileptiform activity, whereas ictal EEG showed a generalized attenuation pattern. Magnetic resonance imaging revealed extensive chronic infarctions, predominantly in the bilateral cerebral watershed areas. At the age of 17, the patient underwent a one-stage complete callosotomy, which only achieved remission of auditory-provoked seizures. Based on this experience and published reports, we propose that the posterior corpus callosum, particularly the isthmus and anterior splenium, may be involved in seizures caused by unexpected sound stimuli.
治療後遠隔期に中枢神経外多発骨・骨髄転移再発を来した髄芽腫の一例

戒能明, 入江正寛, 岩淵蒼太, 中野智太, 鈴木資, 片山紗乙莉, 新妻秀剛, 下田由輝, 金森政之, 遠藤英徳, 笹原洋二, 菊池敦生

日本小児血液・がん学会雑誌　61　(1)　109-109　2024年5月
出版者・発行元： (一社)日本小児血液・がん学会
ISSN：2187-011X

eISSN：2189-5384
治療後遠隔期に中枢神経外多発骨・骨髄転移再発を来した髄芽腫の一例

戒能明, 入江正寛, 岩淵蒼太, 中野智太, 鈴木資, 片山紗乙莉, 新妻秀剛, 下田由輝, 金森政之, 遠藤英徳, 笹原洋二, 菊池敦生

日本小児血液・がん学会雑誌　61　(1)　109-109　2024年5月
出版者・発行元： (一社)日本小児血液・がん学会
ISSN：2187-011X

eISSN：2189-5384
たこつぼ型心筋症を併発したくも膜下出血に安全にクラゾセンタンを投与した1例

佐藤吉通, 西嶌泰生, 熊井萌, 新妻邦泰, 吉田昌弘, 遠藤英徳

脳卒中の外科　52　(3)　231-236　2024年5月
出版者・発行元： (一社)日本脳卒中の外科学会
ISSN：0914-5508

eISSN：1880-4683
The grasp reflex in patients with idiopathic normal pressure hydrocephalus. 国際誌

Junyan Liu, Shigenori Kanno, Chifumi Iseki, Nobuko Kawakami, Kazuo Kakinuma, Kazuto Katsuse, Shiho Matsubara, Shoko Ota, Keiko Endo, Kentaro Takanami, Shin-Ichiro Osawa, Tomohiro Kawaguchi, Hidenori Endo, Shunji Mugikura, Kyoko Suzuki

Journal of neurology　271　(7)　4191-4202　2024年4月8日

DOI： 10.1007/s00415-024-12341-0 　

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OBJECTIVE: To investigate the prevalence and intensity of grasp reflexes and to examine changes in these reflexes after shunt surgery in patients with idiopathic normal pressure hydrocephalus (iNPH). METHODS: We enrolled 147 patients with probable iNPH. A standard procedure was used to determine the presence of grasp reflexes, and the intensity of these reflexes was assessed using a four-category classification. Clinical rating scales and their correlation with grasp reflexes were also evaluated. Grasp reflexes were reassessed in 72 patients 1 year after surgery. RESULTS: We found that approximately 50.3% of patients with iNPH exhibited a positive grasp reflex. Among these patients, 69% exhibited bilateral positivity, while the remaining patients showed unilateral positivity. Furthermore, the intensity of the grasp reflex was significantly correlated with the severity of gait and with cognitive, urinary, motor, and behavioural symptoms. Surgical interventions led to a reduction (41.7%) or maintenance (30.6%) of the reflex intensity in 72.3% of iNPH patients. The changes in reflex intensity showed significant positive correlations with changes in the number of steps of the Timed Up and Go test and Trail Making Test-A scores but not with changes in total scores on the iNPH Grading Scale. CONCLUSION: This retrospective study identified grasp reflexes as a highly prevalent phenomenon in patients with iNPH. These reflexes can assist in evaluating the severity of various symptoms, including cognitive, gait, urinary, motor and emotional symptoms.
Waveform Analysis of STA-MCA Bypass graft in Revascularization Surgery for Moyamoya Disease

Ryuzaburo Kochi, Atsushi Kanoke, Ryosuke Tashiro, Hiroki Uchida, Hidenori Endo

Cerebrovascular Diseases Extra　2024年3月28日
出版者・発行元： S. Karger AG
DOI： 10.1159/000538548 　

eISSN：1664-5456

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Background: Postoperative hyperperfusion syndrome (PHS) is a well-known complication following superficial temporal artery (STA)-middle cerebral artery (MCA) bypass for moyamoya disease (MMD). The early detection of postoperative radiological hyperperfusion (PRH), characterized by a transient increase in local cerebral blood flow (CBF), is crucial for the early diagnosis of PHS. This study aimed to investigate the effectiveness of waveform analysis for early PRH detection.Methods: We reviewed 52 consecutive patients who underwent STA-MCA bypass for MMD. Patients were divided into PRH and non-PRH groups based on the postoperative/preoperative CBF ratio. We collected the intraoperative bypass graft waveform and bypass flow data using a flowmeter. The pulsatile index (PI), an indicator of peripheral vascular resistance (PVR), was calculated from bypass flow data. Next, the newly proposed index of PVR, the ratio of the time from peak to 50% decay and to 100% decay (RT50), was calculated through waveform analysis. The values were then compared between the PRH and non-PRH groups.Results: Twenty-seven of the 52 patients met the inclusion criteria. Fourteen of these 27 patients showed PRH. The RT50, but not the PI, was significantly higher in the PRH group. Linear regression analysis revealed a significant correlation between the RT50 and PI. In the receiver operating characteristic for predicting PRH, the area under the curve of RT50 was 0.750, with a cutoff value of 0.255, a sensitivity of 0.928, and a specificity of 0.500.Conclusions: The RT50 obtained from waveform analysis is associated with PVR and can be useful for the early detection of PRH in patients with MMD.
超選択的Wadaテストで外側皮質言語機能と言語性記銘力の側方性不一致が示された側頭葉てんかんの一例

柿沼一雄, 大沢伸一郎, 浮城一司, 土屋真理夫, 太田祥子, 遠藤英徳, 中里信和, 鈴木匡子

高次脳機能研究　44　(1)　78-79　2024年3月
出版者・発行元： (一社)日本高次脳機能学会
ISSN：1348-4818

eISSN：1880-6554
超選択的Wadaテストにより非典型的側性化が明らかになった難治性てんかん患者の1例

菊地花, 大沢伸一郎, 浮城一司, 柿沼一雄, 勝瀬一登, 太田祥子, 川村藍, 劉軍艶, 遠藤英徳, 中里信和, 鈴木匡子

高次脳機能研究　44　(1)　79-79　2024年3月
出版者・発行元： (一社)日本高次脳機能学会
ISSN：1348-4818

eISSN：1880-6554
Cerebral venous sinus thrombosis detected using diffusion-weighted magnetic resonance imaging during maintenance temozolomide chemotherapy in a patient with glioblastoma: illustrative case. 国際誌

Youhei Takeuchi, Ryuta Saito, Masayuki Kanamori, Kuniyasu Niizuma, Shunji Mugikura, Hidenori Endo

Journal of neurosurgery. Case lessons　7　(9)　2024年2月26日

DOI： 10.3171/CASE23762 　

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BACKGROUND: Cerebral venous sinus thrombosis (CVST) sometimes occurs in the background of hypercoagulopathic disorders, including malignancy, chemotherapy, etc. Glioblastoma (GBM) is a malignancy found in the central nervous system, and reports on cases of GBM complicated by CVST are sparse. The authors herein report a case of GBM complicated by CVST during maintenance temozolomide (TMZ) chemotherapy and describe the utility of diffusion-weighted magnetic resonance imaging (MRI) for the detection of CVST. OBSERVATIONS: A 65-year-old male was treated for left temporal GBM. After surgical removal of the lesion, the patient was treated with chemoradiation therapy, which included 60 Gy local radiation with concomitant TMZ chemotherapy. He was subsequently received TMZ maintenance therapy. Routine MRI performed 7 months after surgery revealed no evidence of tumor recurrence. However, diffusion-weighted imaging (DWI) revealed a high-intensity signal at the posterior portion of the superior sagittal sinus, indicating the presence of a thrombus. In addition to the preexisting symptoms, the patient experienced some disorientation. Angiography revealed an obstruction in the superior sagittal sinus, right transverse sinus, right sigmoid sinus, and straight sinus. His symptoms improved with endovascular and anticoagulant therapy. LESSONS: Performing DWI during routine follow-up can help in the early diagnosis of CVST in patients with malignant gliomas.
Distinguishing IDH mutation status in gliomas using FTIR-ATR spectra of peripheral blood plasma indicating clear traces of protein amyloid aggregation. 国際誌

Saiko Kino, Masayuki Kanamori, Yoshiteru Shimoda, Kuniyasu Niizuma, Hidenori Endo, Yuji Matsuura

BMC cancer　24　(1)　222-222　2024年2月16日

DOI： 10.1186/s12885-024-11970-y 　

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BACKGROUND: Glioma is a primary brain tumor and the assessment of its molecular profile in a minimally invasive manner is important in determining treatment strategies. Among the molecular abnormalities of gliomas, mutations in the isocitrate dehydrogenase (IDH) gene are strong predictors of treatment sensitivity and prognosis. In this study, we attempted to non-invasively diagnose glioma development and the presence of IDH mutations using multivariate analysis of the plasma mid-infrared absorption spectra for a comprehensive and sensitive view of changes in blood components associated with the disease and genetic mutations. These component changes are discussed in terms of absorption wavenumbers that contribute to differentiation. METHODS: Plasma samples were collected at our institutes from 84 patients with glioma (13 oligodendrogliomas, 17 IDH-mutant astrocytoma, 7 IDH wild-type diffuse glioma, and 47 glioblastomas) before treatment initiation and 72 healthy participants. FTIR-ATR spectra were obtained for each plasma sample, and PLS discriminant analysis was performed using the absorbance of each wavenumber in the fingerprint region of biomolecules as the explanatory variable. This data was used to distinguish patients with glioma from healthy participants and diagnose the presence of IDH mutations. RESULTS: The derived classification algorithm distinguished the patients with glioma from healthy participants with 83% accuracy (area under the curve (AUC) in receiver operating characteristic (ROC) = 0.908) and diagnosed the presence of IDH mutation with 75% accuracy (AUC = 0.752 in ROC) in cross-validation using 30% of the total test data. The characteristic changes in the absorption spectra suggest an increase in the ratio of β-sheet structures in the conformational composition of blood proteins of patients with glioma. Furthermore, these changes were more pronounced in patients with IDH-mutant gliomas. CONCLUSIONS: The plasma infrared absorption spectra could be used to diagnose gliomas and the presence of IDH mutations in gliomas with a high degree of accuracy. The spectral shape of the protein absorption band showed that the ratio of β-sheet structures in blood proteins was significantly higher in patients with glioma than in healthy participants, and protein aggregation was a distinct feature in patients with glioma with IDH mutations.
Distant recurrence in the cerebellar dentate nucleus through the dentato-rubro-thalamo-cortical pathway in supratentorial glioma cases. 国際誌

Masayuki Kanamori, Yohei Morishita, Yoshiteru Shimoda, Eiko Yamamori, Shiho Sato, Yoshinari Osada, Shin-Ichiro Osawa, Ichiyo Shibahara, Ryuta Saito, Yukihiko Sonoda, Toshihiro Kumabe, Hidenori Endo

Acta neurochirurgica　166　(1)　83-83　2024年2月14日

DOI： 10.1007/s00701-024-05981-8 　

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BACKGROUND: Distant recurrence can occur by infiltration along white matter tracts or dissemination through the cerebrospinal fluid (CSF). This study aimed to clarify the clinical features and mechanisms of recurrence in the dentate nucleus (DN) in patients with supratentorial gliomas. Based on the review of our patients, we verified the hypothesis that distant DN recurrence from a supratentorial lesion occurs through the dentato-rubro-thalamo-cortical (DRTC) pathway. METHODS: A total of 380 patients with supratentorial astrocytoma, isocitrate dehydrogenase (IDH)-mutant (astrocytoma), oligodendroglioma, IDH mutant and 1p/19q-codeleted (oligodendroglioma), glioblastoma, IDH-wild type (GB), and thalamic diffuse midline glioma, H3 K27-altered (DMG), who underwent tumor resection at our department from 2009 to 2022 were included in this study. Recurrence patterns were reviewed. Additionally, clinical features and magnetic resonance imaging findings before treatment, at the appearance of an abnormal signal, and at further progression due to delayed diagnosis or after salvage treatment of cases with recurrence in the DN were reviewed. RESULTS: Of the 380 patients, 8 (2.1%) had first recurrence in the DN, 3 were asymptomatic when abnormal signals appeared, and 5 were diagnosed within one month after the onset of symptoms. Recurrence in the DN developed in 8 (7.4%) of 108 cases of astrocytoma, GB, or DMG at the frontal lobe or thalamus, whereas no other histological types or sites showed recurrence in the DN. At the time of the appearance of abnormal signals, a diffuse lesion developed at the hilus of the DN. The patterns of further progression showed that the lesions extended to the superior cerebellar peduncle, tectum, tegmentum, red nucleus, thalamus, and internal capsule along the DRTC pathway. CONCLUSION: Distant recurrence along the DRTC pathway is not rare in astrocytomas, GB, or DMG at the frontal lobe or thalamus. Recurrence in the DN developed as a result of the infiltration of tumor cells through the DRTC pathway, not dissemination through the CSF.
Assessment of language lateralization in epilepsy patients using the super-selective Wada test. 国際誌

Kazuo Kakinuma, Shin-Ichiro Osawa, Kazuto Katsuse, Hiroaki Hosokawa, Kazushi Ukishiro, Kazutaka Jin, Kuniyasu Niizuma, Teiji Tominaga, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

Acta neurochirurgica　166　(1)　77-77　2024年2月10日

DOI： 10.1007/s00701-024-05957-8 　

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BACKGROUND: The classical Wada test (cWada), performed by injecting a short-acting anesthetic through the intracarotid route, helps determine language dominance. In the cWada, adverse effects are observed in 10-30% of trials, hindering accurate assessments. In this study, we assessed the effectiveness of the super-selective Wada test (ssWada), a more selective approach for anesthetic infusion into the middle cerebral artery (MCA). METHODS: We retrospectively examined the data of 17 patients with epilepsy who underwent ssWada via anesthetic injection into one M1 segment of the MCA and at least one contralateral trial. RESULTS: The ssWada identified 12 patients with left language dominance, 3 with right language dominance, and 2 with bilateral language distribution. Nine trials on the language dominant side resulted in global aphasia for patients with left- or right language dominance. Of the 13 trials conducted on the non-dominant language side, 12 revealed intact language function and one resulted in confusion. Among these, the outcomes of global aphasia or no language impairment were confirmed in the contralateral trials. Among the 22 trials of unilateral M1 injections in patients with unilateral language dominance, 21 (95.5%) showed either global aphasia or no language impairment, indicating language dominance. CONCLUSIONS: The ssWada yields clear results, with a high rate of over 90% in determining the language dominant hemisphere with few side effects.
The prognostic values of plasma desmosines, crosslinking molecules of elastic fibers, in the disease progression of Moyamoya disease. 国際誌

Ryosuke Tashiro, Riki Anzawa, Tomoo Inoue, Ayame Mikagi, Dan Ozaki, Keita Tominaga, Takashi Inoue, Tomohisa Ishida, Miki Fujimura, Toyonobu Usuki, Hidenori Endo, Kuniyasu Niizuma, Teiji Tominaga

Bioorganic & medicinal chemistry　100　117602-117602　2024年2月1日

DOI： 10.1016/j.bmc.2024.117602 　

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Moyamoya disease (MMD) is a cerebrovascular disease which is characterized by the chronic progression of steno-occlusive changes at the terminal portion of internal carotid arteries and the development of "moyamoya vessels." Dysregulation of the extracellular matrix is regarded as a key pathophysiology underlying unique vascular remodeling. Here, we measured the concentration of elastin crosslinkers desmosine and isodesmosine in the plasma of MMD patients. We aimed to reveal its diagnostic values of desmosines in the progression of steno-occlusive lesions. The concentrations of plasma desmosines were determined by liquid chromatography-tandem mass spectrometry. The temporal profiles of steno-occlusive lesions on magnetic resonance angiography were retrospectively evaluated, and the correlation between the progression of steno-occlusive changes in intracranial arteries and plasma desmosines concentrations was further analyzed. Plasma desmosines were significantly higher in MMD patients with disease progression compared to MMD patients without disease progression. Also, the incidence of disease progression was higher in MMD patients with plasma desmosines levels over limit of quantitation (LOQ) than those with plasma desmosines levels below LOQ. In conclusion, plasma desmosines could be potential biomarkers to predict the progression of steno-occlusive changes in MMD patients.
Selenoprotein P expression in glioblastoma as a regulator of ferroptosis sensitivity: preservation of GPX4 via the cycling-selenium storage. 国際誌

Xi Zheng, Takashi Toyama, Stephanie Siu, Takayuki Kaneko, Hikari Sugiura, Shota Yamashita, Yoshiteru Shimoda, Masayuki Kanamori, Kotoko Arisawa, Hidenori Endo, Yoshiro Saito

Scientific reports　14　(1)　682-682　2024年1月5日

DOI： 10.1038/s41598-024-51259-5 　

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Glioblastoma (GBM) is one of the most aggressive and deadly brain tumors; however, its current therapeutic strategies are limited. Selenoprotein P (SeP; SELENOP, encoded by the SELENOP gene) is a unique selenium-containing protein that exhibits high expression levels in astroglia. SeP is thought to be associated with ferroptosis sensitivity through the induction of glutathione peroxidase 4 (GPX4) via selenium supplementation. In this study, to elucidate the role of SeP in GBM, we analyzed its expression in GBM patients and found that SeP expression levels were significantly higher when compared to healthy subjects. Knock down of SeP in cultured GBM cells resulted in a decrease in GPX1 and GPX4 protein levels. Under the same conditions, cell death caused by RSL3, a ferroptosis inducer, was enhanced, however this enhancement was canceled by supplementation of selenite. These results indicate that SeP expression contributes to preserving GPX and selenium levels in an autocrine/paracrine manner, i.e., SeP regulates a dynamic cycling-selenium storage system in GBM. We also confirmed the role of SeP expression in ferroptosis sensitivity using patient-derived primary GBM cells. These findings indicate that expression of SeP in GBM can be a significant therapeutic target to overcome anticancer drug resistance.
Microvascular decompression is effective for oculomotor nerve palsy caused by posterior cerebral artery compression: A case report. 国際誌

Youhei Takeuchi, Hiroaki Arai, Toshiki Endo, Satoshi Shibuya, Satoru Ohtomo, Hidenori Endo

Surgical neurology international　15　174-174　2024年

DOI： 10.25259/SNI_56_2024 　

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BACKGROUND: Oculomotor nerve palsy is often associated with diabetes mellitus or caused by compression by a cerebral aneurysm. Here, we report a rare case of oculomotor nerve palsy caused by compression by the posterior cerebral artery (PCA). CASE DESCRIPTION: A 66-year-old woman suddenly developed diplopia and right blepharoptosis. Her symptoms suggested incomplete right oculomotor nerve palsy. Magnetic resonance imaging showed that a sharp curve in the right PCA had compressed the right oculomotor nerve. Microvascular decompression surgery was performed. Intraoperative findings showed that the P2 portion of the PCA had caused an indentation in the oculomotor nerve in the prepontine cistern. The transposition of the PCA with a prosthesis released the pressure. After the operation, her right blepharoptosis gradually improved. She had fully recovered by 48 days after the operation. CONCLUSION: Neurovascular compression (NVC) is recognized as the cause of hemifacial spasms, trigeminal neuralgia, and glossopharyngeal neuralgia. This case report demonstrated that NVC can also cause oculomotor nerve palsy. A high index of clinical suspicion can detect vascular compression of the oculomotor nerve. Prompt diagnosis and appropriate surgical management can achieve clinical improvement.
A Case of Hanging with Limited Specific Postmortem Brain Imaging.

Arata Nagai, Tomoya Kobayashi, Kyuzo Kurosawa, Kuniyasu Niizuma, Hidenori Endo

NMC case report journal　11　249-255　2024年

DOI： 10.2176/jns-nmc.2024-0113 　

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In Japan, the number of autopsies has steadily decreased. Therefore, postmortem imaging methods have positioned as valuable supplemental or complementary tools in autopsy procedures. We clinicians are increasingly faced with the need to infer cause of death from postmortem imaging findings. We report computed tomography (CT) and magnetic resonance imaging (MRI) findings of a 41-year-old man who committed suicide by hanging. CT revealed fractures of the left superior horn of the thyroid cartilage. Head MRI showed high signal intensity in the basal ganglia on the T1-weighted image and high-intensity rims along the cerebral cortex on the diffusion-weighted image; however, these were considered normal postmortem changes. There were no significant findings in the heart, major blood vessels, or abdominal organs. The contents of the stomach were minimal, and no tablets or other evidence suggestive of drug overdose were identified. Traumatic changes were not observed. Based on the scene and his circumstances, it was speculated that he died by hanging and an autopsy was not performed. This case highlights the importance of understanding normal postmortem brain imaging changes to estimate the true cause of death.
Paradoxical worsening of ocular symptoms after transvenous embolization of cavernous sinus dural arteriovenous fistula due to coil-induced perifocal inflammation: A case report. 国際誌

Norihiro Iwamoto, Hiroyuki Sakata, Masayuki Ezura, Yoshinari Osada, Hidenori Endo, Teiji Tominaga

Clinical neurology and neurosurgery　236　108086-108086　2024年1月

DOI： 10.1016/j.clineuro.2023.108086 　

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Ocular symptoms usually completely resolve after successful transvenous embolization of cavernous sinus dural arteriovenous fistulas (CS-dAVFs). Herein, we report a case of CS-dAVF in which sinus packing of the superior ophthalmic vein (SOV) caused coil-induced inflammation in orbital tissue, leading to deteriorating ocular symptoms. A 73-year-old woman presented with right-eye exophthalmos and chemosis. Cerebral angiography demonstrated right CS-dAVF, which retrogradely drained into the right SOV. We conducted sinus packing with coils via the right inferior petrosal sinus, resulting in obliteration of the shunts. One day after sinus packing, right exophthalmos and chemosis progressed, suggesting dAVF recurrence. However, no residual angiographic shunts were observed. Orbital magnetic resonance imaging (MRI) revealed edema in intraorbital tissue and gadolinium contrast enhancement of SOV wall. We presumed that the coils in SOV induced perifocal inflammation at the venous wall and surrounding orbital tissue, leading to aggravation of ocular symptoms. Following steroid therapy for 2 months, ocular symptoms and contrast enhancement on orbital MRI significantly improved without anticoagulant treatment. Posttreatment paradoxical worsening of ocular symptoms could be caused by coil-induced inflammation of the SOV wall near the orbital tissue. Steroid therapy could be effective in reducing orbital inflammatory reactions.
Prophylactic management of cerebral vasospasm with clazosentan in real clinical practice: a single-center retrospective cohort study. 国際誌

Hiroyuki Sakata, Atsushi Kanoke, Hiroki Uchida, Shinya Haryu, Shunsuke Omodaka, Naoto Kimura, Masahiro Yoshida, Kuniyasu Niizuma, Teiji Tominaga, Hidenori Endo

Frontiers in neurology　15　1413632-1413632　2024年

DOI： 10.3389/fneur.2024.1413632 　

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INTRODUCTION: Clazosentan, a selective endothelin receptor subtype A antagonist, reduces vasospasm-related morbidity and all-cause mortality following aneurysmal subarachnoid hemorrhage (SAH) in the Japanese population, as demonstrated by a recent randomized phase 3 trial. However, evidence to suggest clazosentan should be prioritized over the current standard of care to prevent cerebral vasospasm is still lacking. Therefore, we investigated the efficacy and safety of clazosentan in comparison with conventional postoperative management in real-world clinical practice. METHODS: We conducted a single-center, retrospective, observational cohort study using prospectively collected data from consecutive patients with aneurysmal SAH. After clazosentan was approved for use in Japan, the conventional postoperative management protocol, composed of intravenous fasudil chloride and oral cilostazol (control group, April 2021 to March 2022), was changed to the clazosentan protocol (clazosentan group, April 2022 to March 2023). The primary endpoint was the incidence of vasospasm-related symptomatic infarction. The secondary endpoints were favorable functional outcomes (modified Rankin scale score < 3) at discharge, angiographic vasospasm, and the need for rescue therapy for delayed cerebral ischemia. RESULTS: The analysis included 100 and 81 patients in the control and clazosentan groups, respectively. The incidence of vasospasm-related symptomatic infarction was significantly lower in the clazosentan group than in the control group (6.2% vs. 16%, p = 0.032). Multiple logistic analyses demonstrated that the use of clazosentan was independently associated with fewer incidence of vasospasm-related symptomatic infarct (23.8% vs. 47.5%, odds ratio 0.34 [0.12-0.97], p = 0.032). Clazosentan was significantly associated with favorable outcomes at discharge (79% vs. 66%, p = 0.037). Moreover, both the incidence of angiographic vasospasm (25.9% vs. 44%, p = 0.013) and the need for rescue therapy (16.1% vs. 34%, p = 0.006) was lower in the clazosentan group. The occurrence of pulmonary edema was significantly higher with clazosentan use (19.8% vs. 5%, p = 0.002), which did not result in morbidity. CONCLUSION: A postoperative management protocol centering on clazosentan was associated with the reduced vasospasm-related symptomatic infarction and improved clinical outcomes compared to the conventional management protocol in Japanese clinical practice. Clazosentan might be a promising treatment option for counteracting cerebral vasospasm after aneurysmal SAH.
Endovascular Treatment of Wide-Neck Bifurcation Aneurysm: Recent Trends in Coil Embolization with Adjunctive Technique.

Shinya Haryu, Hiroyuki Sakata, Yasushi Matsumoto, Kuniyasu Niizuma, Hidenori Endo

Journal of neuroendovascular therapy　18　(3)　75-83　2024年

DOI： 10.5797/jnet.ra.2023-0072 　

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Wide-neck bifurcation aneurysms (WNBAs) are sometimes challenging to treat. During endovascular treatment, it is important to prevent coil deviation and preserve normal vessels. Adjunctive balloon- and stent-assisted techniques have been developed. A meta-analysis of endovascular treatments of WNBAs revealed that only 40% of patients had complete occlusion. Recently, novel devices have been developed to expand the range of treatment options. Flow-diverter stents and intra-aneurysmal flow disruption devices do not require coils; however, coil embolization remains the standard procedure used by many neurointerventionists. This review describes the recent trends in adjunctive techniques for supporting coil embolization for WNBAs. We referred to literature on balloon-assisted techniques, stent-assisted techniques, Y-stenting, PulseRider, Barrel stents, Comaneci temporary stents, pCONUS, and eCLIPs. These reports showed that adequate embolization rates were generally greater than 80%, and the complete occlusion rate was as high as 94.6%. All devices had a relatively high occlusion rate; however, it may be inaccurate to simply compare each device because of the heterogeneity of the studies. It is important to select the best treatment for each individual case by considering not only literature-based efficacy and safety but also patient background, aneurysm characteristics, and operator experience.
[Academia-Industry Alliance: Recent Trend].

Atsuhiro Nakagawa, Leor Perl, John Lee, Narumi Harada-Shoji, Chiharu Ota, Takuya Shiga, Sako Sunami, Kuniyasu Niizuma, Hidenori Endo, Hideo Harigae, Teiji Tominaga

No shinkei geka. Neurological surgery　52　(1)　213-225　2024年1月

DOI： 10.11477/mf.1436204899 　

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Industry-academia Collaboration is an academic activity within academia(educational institutions such as universities, research institutes, etc.)formed to research and develop new technologies, create new businesses and knowledge, and recruit outsourcing human resources. There is a collaboration between an industry(a private company, a group that engages in broad commercial activities and links research and development directly to economic activity)and academia. Amidst the dramatic changes in the environment surrounding the goals of research and development of new technologies and the creation of new businesses, there are changes in what academia can do complementarily. We will outline the changes and current situation, including the efforts of the Tohoku University Hospital.
小児・AYA世代脳腫瘍治療の最前線を知る小児・AYA世代脳腫瘍に対する外科治療

隈部俊宏, 柴原一陽, 金森政之, 遠藤英徳

日本小児血液・がん学会雑誌　60　(4)　256-256　2023年11月
出版者・発行元： (一社)日本小児血液・がん学会
ISSN：2187-011X

eISSN：2189-5384
Randomized placebo-controlled trial of CL2020, an allogenic muse cell-based product, in subacute ischemic stroke. 国際誌

Kuniyasu Niizuma, Shin-Ichiro Osawa, Hidenori Endo, Shin-Ichi Izumi, Kota Ataka, Akihiro Hirakawa, Masao Iwano, Teiji Tominaga

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism　271678X231202594　2023年9月27日

DOI： 10.1177/0271678X231202594 　

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Effective treatments for stroke after the acute phase remain elusive. Muse cells are endogenous, pluripotent, immune-privileged stem cells capable of selectively homing to damaged tissue after intravenous injection and replacing damaged/lost cells via differentiation. This randomized, double-blind, placebo-controlled trial enrolled ischemic stroke patients with modified Rankin Scale (mRS) ≥3. Randomized patients received a single intravenous injection of an allogenic Muse cell-based product, CL2020 (n = 25), or placebo (n = 10), without immunosuppressant, 14-28 days after stroke onset. Safety (primary endpoint: week 12) and efficacy (mRS, other stroke-specific measures) were assessed up to 52 weeks. Key efficacy endpoint was response rate (percentage of patients with mRS ≤2 at week 12). To week 12, 96% of patients in the CL2020 group experienced adverse events and 28% experienced adverse reactions (including one Grade 4 status epilepticus), compared with 100% and 10%, respectively, in the placebo group. Response rate was 40.0% (95% CI, 21.1-61.3) in the CL2020 group and 10.0% (0.3-44.5) in the placebo group; the lower CI in the CL2020 group exceeded the preset efficacy threshold (8.7% from registry data). This randomized placebo-controlled trial demonstrated CL2020 is a possible effective treatment for subacute ischemic stroke.Registry information: JAPIC Clinical Trials Information site (JapicCTI-184103, URL: https://www.clinicaltrials.jp/cti-user/trial/ShowDirect.jsp?japicId=JapicCTI-184103).
Six-month Outcomes after PulseRider- and Conventional Single Stent-assisted Embolization for Bifurcation Aneurysms: A Propensity-adjusted Comparison.

Shunsuke Omodaka, Yasushi Matsumoto, Takeshi Fujimori, Hiroyuki Sakata, Kenichi Sato, Kuniyasu Niizuma, Hidenori Endo, Teiji Tominaga

Neurologia medico-chirurgica　2023年9月23日

DOI： 10.2176/jns-nmc.2023-0082 　

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Endovascular treatment of wide-necked bifurcation aneurysms (WNBAs) remains challenging despite using a stent. PulseRider is a novel device specifically designed to treat WNBAs, protecting both daughter branches, but the outcomes have not been compared with conventional single stent-assisted embolization. This study aimed to compare the six-month outcomes of PulseRider and single stent-assisted embolization for intracranial unruptured WNBAs using propensity score adjustment. Between February 2012 and October 2021, 46 unruptured WNBAs (34 basilar and 12 middle cerebral arteries) smaller than 10 mm in diameter were treated with PulseRider-assisted embolization (n = 17) or single stent-assisted embolization (n = 29). The immediate and six-month outcomes were compared using inverse probability of treatment weighting analysis. The immediate adequate occlusion rates for the PulseRider- and single stent-assisted embolization were similar (47.1% vs. 62.1%). At six months, adequate occlusion rates for the two groups were also similar (94.1% vs. 86.2%). However, the complete obliteration rate was significantly high after PulseRider-assisted embolization (88.2% vs. 41.4%, adjusted OR 10.54, 95% CI 1.93-57.63). The angiographical improvement rate was also significantly high after PulseRider-assisted embolization (70.6% vs. 37.9%, adjusted OR 6.06, 95% CI 1.54-23.76). The neurologic thromboembolic complication rate was 0% after PulseRider-assisted embolization and 3.4% after single stent-assisted embolization. PulseRider-assisted embolization of WNBAs smaller than 10 mm in diameter was associated with complete obliteration and angiographical improvement at six months. The unique shape of the PulseRider might contribute to the improved midterm aneurysm occlusion.
Visualization of the lenticulostriate arteries, long insular arteries, and long medullary arteries on intra-arterial computed tomography angiography with ultrahigh resolution in patients with glioma. 国際誌

Yoshinari Osada, Masayuki Kanamori, Shin-Ichiro Osawa, Shingo Kayano, Hiroki Uchida, Yoshiteru Shimoda, Shunji Mugikura, Teiji Tominaga, Hidenori Endo

Acta neurochirurgica　2023年9月20日

DOI： 10.1007/s00701-023-05794-1 　

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PURPOSE: The anatomical association between the lesion and the perforating arteries supplying the pyramidal tract in insulo-opercular glioma resection should be evaluated. This study reported a novel method combining the intra-arterial administration of contrast medium and ultrahigh-resolution computed tomography angiography (UHR-IA-CTA) for visualizing the lenticulostriate arteries (LSAs), long insular arteries (LIAs), and long medullary arteries (LMAs) that supply the pyramidal tract in two patients with insulo-opercular glioma. METHODS: This method was performed by introducing a catheter to the cervical segment of the internal carotid artery. The infusion rate was set at 3 mL/s for 3 s, and the delay time from injection to scanning was determined based on the time-to-peak on angiography. On 2- and 20-mm-thick UHR-IA-CTA slab images and fusion with magnetic resonance images, the anatomical associations between the perforating arteries and the tumor and pyramidal tract were evaluated. RESULTS: This novel method clearly showed the relationship between the perforators that supply the pyramidal tract and tumor. It showed that LIAs and LMAs were far from the lesion but that the proximal LSAs were involved in both cases. Based on these results, subtotal resection was achieved without complications caused by injury of perforators. CONCLUSION: UHR-IA-CTA can be used to visualize the LSAs, LIAs, and LMAs clearly and provide useful preoperative information for insulo-opercular glioma resection.
Atypical sagittal suture craniosynostosis: pathological considerations for early closure of the anterior part of the sagittal suture. 国際誌

Inukai Madoka, Hayashi Toshiaki, Kimiwada Tomomi, Takeyama Junji, Sanada Takehiko, Shimanuki Yoshihisa, Kitami Masahiro, Kumabe Toshihiro, Endo Hidenori

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery　2023年9月6日

DOI： 10.1007/s00381-023-06141-6 　

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Sagittal suture synostosis is one of the most common craniosynostoses and is often diagnosed by characteristic narrow and long skull shape, scaphocephaly. However, some patients with sagittal suture synostosis do not present with typical scaphocephaly, making early diagnosis difficult. In this study, five cases of characteristic skull deformity showing a narrowing of the cranium posterior to the coronal suture on computed tomography (CT) are presented. The three older children presented with papilledema and intellectual disability and a closed sagittal suture on CT. The two infant cases were diagnosed with the characteristic cranial deformities with aggravation of the deformity over time, but sagittal suture closure was not evident on CT. All patients underwent cranial remodeling surgery. In the two infant cases, the histopathological findings showed that the anterior part of the sagittal suture was firmly fused with fibrous tissue without bony fusion. These findings suggested that narrowing of the cranium posterior to the coronal suture might be due to functional fusion of the anterior portion of the sagittal suture prior to bony fusion. In an infant presenting with such a deformity that shows aggravation of the deformity over time, surgical treatment should be considered.
超選択的頭蓋内麻酔薬注入により、患者は焦点切除後の神経症状を主観的に評価できる

大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 石田誠, 新妻邦泰, 神一敬, 植松貢, 中里信和, 遠藤英徳

てんかん研究　41　(2)　358-358　2023年9月
出版者・発行元： (一社)日本てんかん学会
ISSN：0912-0890

eISSN：1347-5509
Potential Contribution of Ultrasonography Assistance for the Safe and Steady Procedure of Endoscopic Intracerebral Hematoma Evacuation: A Retrospective Cohort Study. 国際誌

Yuki Kitamura, Tomohiro Kawaguchi, Hiroki Uchida, Hidenori Endo, Teiji Tominaga

Journal of neurological surgery. Part A, Central European neurosurgery　84　(5)　439-444　2023年9月

DOI： 10.1055/a-1877-0184 　

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BACKGROUND: Endoscopic hematoma evacuation is one of the most promising procedures for the treatment of intracerebral hemorrhage (ICH) to avoid severe outcomes, such as death or dependency. However, the effect of the procedure on the functional outcome remains controversial. Thus, standardization and sophistication are required to enhance the surgical results. This study aimed to evaluate the potential efficacy of ultrasonography (US) in endoscopic hematoma evacuation. METHODS: This study included 39 consecutive patients with spontaneous supratentorial ICH who underwent endoscopic hematoma evacuation between April 2019 and July 2021. The patients were divided into two groups, namely, surgery with or without US assistance. Rebleeding and evacuation rate were set as the primary endpoints, and operation time, requirement for repeat puncture, and modified Rankin scale at discharge were set as the secondary endpoints. During surgery, the burr hole was placed, and the dura mater was widely opened. The US probe was applied on the brain surface via the burr hole to detect the depth and direction of the hematoma cavity. With US assistance, the hematoma cavity was punctured with a cannula, and the transparent port was introduced into the hematoma cavity along the tract. The hematoma was gently evacuated with the irrigation-suction instrument. RESULTS: Of the 39 cases, 9 underwent endoscopic hematoma evacuation with US assistance. Rebleeding was noted in 0 and 2 (6.7%) patients with and without US assistance, respectively (p = 0.43). The mean hematoma evacuation rates were 78.6 and 80.6% in patients with and without US assistance, respectively (p = 0.80). In all cases with US assistance, the cavity could be reached with a single tap. However, repeat puncture was required in 20 (66.7%) cases without US assistance (p = 0.04). In one case, an unexpected residual hematoma was detected using US, which was applied after hematoma evacuation and before wound closure. The operation time was not extended even if US was used during the surgery. CONCLUSIONS: US-assisted hematoma evacuation is an effective procedure that can assist in the precise insertion of the puncture cannula and exclusion of the residual hematoma. US might contribute toward improving the accuracy of each step of the procedure, thus leading to better clinical outcomes.
Five-Year Stroke Risk and Its Predictors in Asymptomatic Moyamoya Disease: Asymptomatic Moyamoya Registry (AMORE). 国際誌

Satoshi Kuroda, Shusuke Yamamoto, Takeshi Funaki, Miki Fujimura, Hiroharu Kataoka, Tomohito Hishikawa, Jun Takahashi, Hidenori Endo, Tadashi Nariai, Toshiaki Osato, Nobuhito Saito, Norihiro Sato, Emiko Hori, Yoichi M Ito, Susumu Miyamoto

Stroke　54　(6)　1494-1504　2023年6月

DOI： 10.1161/STROKEAHA.122.041932 　

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BACKGROUND: Long-term outcomes are unknown in patients with asymptomatic moyamoya disease. In this report, we aimed to clarify their 5-year risk of stroke and its predictors. METHODS: We are conducting a multicenter, prospective cohort study (Asymptomatic Moyamoya Registry) in Japan. Participants were eligible if they were 20 to 70 years, had bilateral or unilateral moyamoya disease, experienced no episodes suggestive of TIA and stroke; and were functionally independent (modified Rankin Scale score 0-1). Demographic and radiological information was collected at enrollment. In this study, they are still followed up for 10 years. In this interim analysis, we defined the primary end point as a stroke occurring during a 5-year follow-up period. Independent predictors for stroke were also determined, using a stratification analysis method. RESULTS: Between 2012 and 2015, we enrolled 109 patients, of whom 103 patients with 182 involved hemispheres completed the 5-year follow-up. According to the findings on DSA and MRA, 143 hemispheres were judged as moyamoya disease and 39 hemispheres as questionable manifestations (isolated middle cerebral artery stenosis). The patients with questionable hemispheres were significantly older, more often male, and more frequently had hypertension than those with moyamoya hemisphere. Moyamoya hemispheres developed 7 strokes, including 6 hemorrhagic and 1 ischemic stroke, during the first 5 years. The annual risk of stroke was 1.4% per person, 0.8% per hemisphere, and 1.0% per moyamoya hemisphere. Independent predictor for stroke was Grade-2 choroidal anastomosis (hazard ratio, 5.05 [95% CI, 1.24-20.6]; P=0.023). Furthermore, microbleeds (hazard ratio, 4.89 [95% CI, 1.13-21.3]; P=0.0342) and Grade-2 choroidal anastomosis (hazard ratio, 7.05 [95% CI, 1.62-30.7]; P=0.0093) significantly predicted hemorrhagic stroke. No questionable hemispheres developed any stroke. CONCLUSIONS: The hemispheres with asymptomatic moyamoya disease may carry a 1.0% annual risk of stroke during the first 5 years, the majority of which are hemorrhagic stroke. Grade-2 choroidal anastomosis may predict stroke, and the microbleeds and Grade-2 choroidal anastomosis may carry the risk for hemorrhagic stroke. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: UMIN000006640.
Evaluation of cholesterol crystals in carotid plaque by dual energy computed tomography 国際誌

Takuya Saito, Hidenori Endo, Daisuke Ando, Itsuki Miyagi, Yuichi Kawabata, Mika Watanabe, Atsushi Saito, Miki Fujimura, Yukako Yazawa

Neuroradiology　65　(5)　979-982　2023年5月

DOI： 10.1007/s00234-023-03138-5 　

ISSN：0028-3940

eISSN：1432-1920
Hemifacial spasm associated with posterior inferior cerebellar artery aneurysm: illustrative case. 国際誌

Gaku Inoue, Hidenori Endo, Atsushi Kanoke, Tomohiro Kawaguchi, Teiji Tominaga

Journal of neurosurgery. Case lessons　5　(15)　2023年4月10日

DOI： 10.3171/CASE23102 　

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BACKGROUND: Hemifacial spasms (HFSs) complicated by intracranial aneurysms are rare. Recently, endovascular treatment has been widely used for this disease entity and can allow the cessation of intracranial aneurysm arterial pulsation, leading to recovery from the HFS. Here, the authors present a case of HFS associated with an ipsilateral posterior inferior cerebellar artery (PICA) aneurysm successfully treated with open surgery. OBSERVATIONS: A 68-year-old woman was annually followed-up for an incidentally found right PICA aneurysm. Over 3 years, the PICA aneurysm gradually increased in size, which eventually led to right HFS. An axial fast spoiled gradient-recalled echo sequence with gadolinium enhancement showed the PICA aneurysm compressing the root exit zone (REZ), which was attributed as the cause of the HFS. However, a fusion image of the three-dimensional T1-weighted fast spin-echo sequence and magnetic resonance angiogram clearly showed a direct contact between the REZ and the anterior inferior cerebellar artery (AICA), which was located at the apex of the PICA aneurysm. Intraoperatively, the AICA was found compressing the REZ; hence, microvascular decompression with aneurysmal clipping was performed. The HFS resolved immediately after surgery. LESSONS: In cases of HFS associated with an ipsilateral intracranial aneurysm, a detailed neuroradiological assessment to identify the responsible lesion is important to use the most optimal treatment of choice.
The use of vessel wall imaging to detect a de novo microaneurysm on the periventricular anastomoses in moyamoya disease: illustrative case. 国際誌

Atsuhiko Ninomiya, Hidenori Endo, Ryosuke Tashiro, Atsushi Kanoke, Teiji Tominaga

Journal of neurosurgery. Case lessons　5　(12)　2023年3月20日

DOI： 10.3171/CASE2365 　

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BACKGROUND: Moyamoya disease (MMD) is linked to the formation of intracranial aneurysms. The authors recently observed an effective use of magnetic resonance vessel wall imaging (MR-VWI) to detect de novo unruptured MMD-associated microaneurysms. OBSERVATIONS: The authors describe a 57-year-old female who was diagnosed with MMD 6 years ago after suffering a left putaminal hemorrhage. MR-VWI revealed point-like enhancement in the right posterior paraventricular region during the annual follow-up. On the T2-weighted image, this lesion was surrounded by high intensity. Angiography revealed a microaneurysm in the periventricular anastomosis. Right combined revascularization surgery was performed to prevent future hemorrhagic events. Another de novo circumferential enhanced lesion on MR-VWI appeared in the left posterior periventricular region 3 months after surgery. Angiography revealed that the enhanced lesion was a de novo microaneurysm on the periventricular anastomosis. The left combined revascularization surgery went well. The bilateral microaneurysms vanished on follow-up angiography. LESSONS: Unruptured MMD-associated microaneurysms on the periventricular anastomosis can be detected using MR-VWI. Revascularization surgery can eliminate microaneurysms by reducing hemodynamic stress on the periventricular anastomosis.
Letter to the Editor on "Pseudo-Enhancement in Intracranial Aneurysms on Black-Blood MRI: Effects of Flow Rate, Spatial Resolution, and Additional Flow Suppression". 国際誌

Naoko Mori, Hidenori Endo, Shunji Mugikura

Journal of magnetic resonance imaging : JMRI　57　(3)　964-964　2023年3月

DOI： 10.1002/jmri.28293 　
【脳動脈瘤の温故知新現在までの治療を紡ぐ永久保存版】脳血管攣縮の最新治療

遠藤英徳, 新妻邦泰, 冨永悌二

脳神経外科速報　33　(2)　208-210　2023年3月
出版者・発行元： (株)メディカ出版
ISSN：0917-1495
Principal component analysis of texture features for grading of meningioma: not effective from the peritumoral area but effective from the tumor area. 国際誌

Naoko Mori, Shunji Mugikura, Toshiki Endo, Hidenori Endo, Yo Oguma, Li Li, Akira Ito, Mika Watanabe, Masayuki Kanamori, Teiji Tominaga, Kei Takase

Neuroradiology　65　(2)　257-274　2023年2月

DOI： 10.1007/s00234-022-03045-1 　

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PURPOSE: To investigate whether texture features from tumor and peritumoral areas based on sequence combinations can differentiate between low- and non-low-grade meningiomas. METHODS: Consecutive patients diagnosed with meningioma by surgery (77 low-grade and 28 non-low-grade meningiomas) underwent preoperative magnetic resonance imaging including T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and contrast-enhanced T1WI (CE-T1WI). Manual segmentation of the tumor area was performed to extract texture features. Segmentation of the peritumoral area was performed for peritumoral high-signal intensity (PHSI) on T2WI. Principal component analysis was performed to fuse the texture features to principal components (PCs), and PCs of each sequence of the tumor and peritumoral areas were compared between low- and non-low-grade meningiomas. Only PCs with statistical significance were used for the model construction using a support vector machine algorithm. k-fold cross-validation with receiver operating characteristic curve analysis was used to evaluate diagnostic performance. RESULTS: Two, one, and three PCs of T1WI, apparent diffusion coefficient (ADC), and CE-T1WI, respectively, for the tumor area, were significantly different between low- and non-low-grade meningiomas, while PCs of T2WI for the tumor area and PCs for the peritumoral area were not. No significant differences were observed in PHSI. Among models of sequence combination, the model with PCs of ADC and CE-T1WI for the tumor area showed the highest area under the curve (0.84). CONCLUSION: The model with PCs of ADC and CE-T1WI for the tumor area showed the highest diagnostic performance for differentiating between low- and non-low-grade meningiomas. Neither PHSI nor PCs in the peritumoral area showed added value.
Investigation of cystine as differential diagnostic biomarker between astrocytomas and oligodendrogliomas based on global- and targeted analysis using liquid chromatography/tandem mass spectrometric analysis

Masahiro Watanabe, Masamitsu Maekawa, Masayuki Kanamori, Minami Yamauchi, Ai Abe, Yoshiteru Shimoda, Ryuta Saito, Hidenori Endo, Nariyasu Mano

Advances in Biomarker Sciences and Technology　5　76-85　2023年
出版者・発行元： Elsevier BV
DOI： 10.1016/j.abst.2023.09.001 　

ISSN：2543-1064
Efficacy of repeat arterial spin labeling for angiogram-negative ruptured micro-arteriovenous malformation: A case report. 国際誌

Ryuzaburo Kochi, Yasuhiro Suzuki, Hiroshi Yamazaki, Takashi Aikawa, Hidenori Endo, Teiji Tominaga

Surgical neurology international　14　119-119　2023年

DOI： 10.25259/SNI_200_2023 　

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BACKGROUND: Diagnosing ruptured micro-arteriovenous malformation (AVM) could be difficult using digital subtraction angiography (DSA) in the acute stage, and a repeat DSA is recommended in DSA-negative cases. Arterial spin labeling (ASL) is a useful noninvasive tool for detecting AVM, but the efficacy of a repeat ASL for DSA and ASL-negative ruptured micro-AVM in the acute stage is unclear. Here, we report a case of ruptured micro-AVM that was not detected in the acute stage by ASL but in the chronic stage by ASL. CASE DESCRIPTION: A 43-year-old man developed right upper-extremity paralysis, and computed tomography (CT) revealed a left frontal lobe hemorrhage. Magnetic resonance imaging, including ASL, CT angiography, and DSA, showed no abnormal findings associated with hemorrhage in the acute stage. The second ASL 93 days after the hemorrhage showed a high signal on the cortical vein of the left frontal lobe and superior sagittal sinus, and subsequent DSA detected a micro-AVM in the left precentral gyrus. CONCLUSION: Repeat ASL is less invasive and useful for detecting micro-AVMs which showed no findings on ASL and DSA in the acute stage.
Retiform endothelial hyperplasia mimicking cavernous malformation as a late complication of Gamma Knife radiosurgery. 国際誌

Jun Kawagishi, Hidefumi Jokura, Mika Watanabe, Miki Fujimura, Kuniyasu Niizuma, Hidenori Endo, Hiroyoshi Suzuki, Teiji Tominaga

Journal of neurosurgery　139　(1)　1-11　2022年12月23日

DOI： 10.3171/2022.11.JNS221535 　

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OBJECTIVE: Gamma Knife radiosurgery (GKRS) is a powerful tool for the management of arteriovenous malformations; however, newly formed mass lesions resembling cavernous malformations are a rare late complication of GKRS. In this retrospective study, the authors tried to clarify the unique histological features of these mass lesions. METHODS: The authors retrospectively reviewed the clinical course of 889 patients who had undergone GKRS for arteriovenous malformations at their institute from 1991 to 2021. Among the 848 patients who had been followed up periodically with neuroradiological imaging, 37 developed a mass lesion mimicking a cavernous malformation and underwent surgical removal of the lesion. The median volume of the original nidus was 3.7 cm3 (range 0.07-30.5 cm3), and the median prescription dose was 21 Gy (range 12-25 Gy). The histological characteristics and radiological and clinical features of the 37 patients were investigated. RESULTS: Histological examination showed an organized hematoma and a structure termed "retiform endothelial hyperplasia" (RFEH) consisting of endothelium forming multiple lumen-like vascular channels mimicking cavernous malformations but lacking the subendothelial connective tissue that forms the typical vascular wall structure found in cavernous angioma and capillary telangiectasia. RFEH was detected a median of 10.8 years (range 3.2-27.4 years) after GKRS. Neuroimaging showed hematoma surrounded by massive brain edema in all 37 patients. Symptoms caused by mass effect of the lesion and perifocal edema worsened relatively rapidly but completely disappeared after surgery. No recurrence or morbidity occurred after the surgery. CONCLUSIONS: The delayed formation of RFEH that is mimicking a cavernous malformation neuroradiologically but is histologically distinct from a vascular malformation is a potential complication of GKRS. Its progressive clinical course suggests that surgical removal should be considered for symptomatic patients and/or patients with an apparent radiological mass sign.
Bypass surgery for ruptured dissecting aneurysms of the proximal posterior cerebral artery: illustrative case. 国際誌

Tetsuya Hayashi, Hidenori Endo, Atsushi Kanoke, Tomohiro Kawaguchi, Teiji Tominaga

Journal of neurosurgery. Case lessons　4　(15)　2022年10月10日

DOI： 10.3171/CASE22341 　

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BACKGROUND: Posterior cerebral artery (PCA) dissecting aneurysms commonly occur in the proximal PCA and are considered rare. The treatment of proximal PCA dissecting aneurysms is challenging because of the existence of perforators supplying the vital neural structures. Recently, endovascular intervention has been used; however, concerns for ischemic or hemorrhagic complications exist. OBSERVATIONS: A 54-year-old woman presented with subarachnoid hemorrhage due to dissecting aneurysm rupture at the P1-P2 junction of the PCA. The thalamoperforating artery (TPA) and medial posterior choroidal artery (MPchA) originated from the proximal end and the distal end of the aneurysm, respectively. Additionally, the posterior communicating artery (PcomA) connected with the dissected segment. To preserve these perforators, we performed surgical trapping combined with superficial temporal artery (STA) PCA anastomosis. Clips were applied for trapping the proximal and distal end of the aneurysm, with preservation of the TPA and MPchA origin. PcomA was left open for blood flow preservation to the perforators directly arising from the aneurysm. The postoperative course was uneventful, and the patient was discharged. LESSONS: Surgical trapping using STA-PCA bypass could be a treatment of choice for proximal PCA dissecting aneurysms, considering its potential for cure and prevention of ischemic complications.
[Cerebral Blood Vessels and Infection].

Atsushi Kanoke, Hidenori Endo, Teiji Tominaga

No shinkei geka. Neurological surgery　50　(5)　961-968　2022年9月

DOI： 10.11477/mf.1436204655 　

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Infectious intracranial aneurysms(IIAs)are rare cerebrovascular complications of systemic infections induced by microbial infiltration and degradation of the arterial vessel wall. Prospective or population-wide studies of the epidemiology, natural history, or management of IIAs have not been conducted. In this study, we present the epidemiological and angiographical features, management, and outcomes of IIAs based on published case series and retrospective studies. Most IIAs were small in size(< 5 mm), with aneurysms located in the middle cerebral artery followed by the posterior cerebral artery. Endovascular interventions for IIAs have increased since coils, liquid embolic materials, and microcatheter became more sophisticated, allowing them to reach more distal branches. Open surgery is still required in cases with large clots or in cases involving branches feeding the eloquent areas, which cannot be sacrificed. These multimodal approaches for managing IIAs have achieved satisfactory results. Septic cavernous sinus thrombosis is also a rare, life-threatening complication of head and neck infections. Several antibiotics and antivirals are used in combination with anticoagulants. However, no consensus has been reached because of a lack of randomized controlled trials and large population-based studies.
Intraoperative motor-evoked potential monitoring during coil embolization for anterior choroidal artery aneurysms. 国際誌

Akira Ito, Kenichi Sato, Kuniyasu Niizuma, Hidenori Endo, Yasushi Matsumoto, Teiji Tominaga

Neuroradiology　64　(6)　1221-1229　2022年6月

DOI： 10.1007/s00234-021-02847-z 　

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PURPOSE: Intraoperative motor-evoked potential (MEP) monitoring is widely used in the neck clipping of cerebral aneurysms. Little is known regarding the usefulness of intraoperative MEP monitoring in endovascular aneurysm surgery. The purpose of this study was to validate the feasibility of intraoperative MEP monitoring during the coil embolization of anterior choroidal artery (AChA) aneurysms. METHODS: Clinical and angiographic data of consecutive patients who underwent coil embolization for unruptured AChA aneurysms with or without intraoperative MEP monitoring between January 2014 and December 2018 at our institute were abstracted and analyzed retrospectively. RESULTS: Twenty-three unruptured AChA aneurysms were treated. Eleven patients received MEP monitoring, and three of them experienced intraoperative reduction or disappearance of the MEP wave. Even during MEP changes, AChA filling showed no change in any of the three cases. Although one case with MEP monitoring encountered the disappearance of AChA filling, there was no change in MEP. This might be due to retrograde filling of the AChA from the anastomosis with the lateral posterior choroidal artery. AChA blood flow detected by angiography did not always reflect MEP status. When comparing the presence or absence of MEP monitoring, the volume embolization ratio of coiled aneurysms was significantly better in the MEP group. CONCLUSION: Intraoperative MEP monitoring during endovascular coiling for AChA aneurysms may be feasible. AChA blood flow detected by angiography does not always reflect MEP status.
2021 Japanese Guidelines for the Management of Moyamoya Disease: Guidelines from the Research Committee on Moyamoya Disease and Japan Stroke Society.

Miki Fujimura, Teiji Tominaga, Satoshi Kuroda, Jun C Takahashi, Hidenori Endo, Kuniaki Ogasawara, Susumu Miyamoto

Neurologia medico-chirurgica　62　(4)　165-170　2022年4月15日

DOI： 10.2176/jns-nmc.2021-0382 　
Rupture of an adjacent cerebral aneurysm following the deployment of a Pipeline embolization device: illustrative case 国際誌

Atsushi Nakayashiki, Hiroyuki Sakata, Masayuki Ezura, Hidenori Endo, Takashi Inoue, Atsushi Saito, Teiji Tominaga

Journal of Neurosurgery: Case Lessons　3　(14)　2022年4月4日
出版者・発行元： Journal of Neurosurgery Publishing Group (JNSPG)
DOI： 10.3171/case21651 　

eISSN：2694-1902

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BACKGROUND Although the Pipeline embolization device (PED) is effective for intracranial aneurysm treatment, its impact on the surrounding vascular structure is unknown. OBSERVATIONS A 71-year-old woman was incidentally found to have a simultaneous large posterior communicating artery aneurysm and an ipsilateral small anterior choroidal artery aneurysm. She underwent flow diversion therapy for both aneurysms with a PED, but the distal shortening of the PED after deployment led to the exposure of the anterior choroidal artery aneurysm. Follow-up angiography revealed complete obliteration of the posterior communicating artery aneurysm, but the anterior choroidal artery aneurysm remained. Three years after the endovascular surgery, the patient experienced a subarachnoid hemorrhage due to the rupture of the anterior choroidal artery aneurysm. Retrospective analysis of angiographic images revealed a change in the vascular geometry surrounding the ruptured aneurysm after PED deployment; this was further accompanied by an increase in the flow velocity inside the aneurysm. LESSONS Because PED use might induce the adverse effects on the adjacent uncovered aneurysm by changing the vascular geometry and hemodynamic stress, a cautious therapeutic strategy, such as proper placement of the stent and using a longer and appropriate-sized PED, should be chosen when deploying the PED.
Visual Impairment due to a large paraclinoid aneurysm treated with parent artery occlusion and bypass: A case report. 国際誌

Yuya Kato, Naoto Kimura, Hidenori Endo, Youhei Takeuchi, Michiko Yokosawa, Takayuki Sugawara, Teiji Tominaga

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association　31　(4)　106280-106280　2022年4月

DOI： 10.1016/j.jstrokecerebrovasdis.2021.106280 　

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INTRODUCTION: Paraclinoid internal carotid artery (ICA) aneurysms can sometimes cause visual field disturbances due to their size, and it is challenging to treat either surgically or using endovascular techniques. Flow diverters generally have positive outcomes, but sometimes in symptomatic aneurysms, we see the thrombosed section becomes enlarged. Therefore, optimal treatment strategies are difficult to determine. CASE: A 68-year-old woman presented with a chief complaint of vision loss in the left eye. A large wide-necked saccular aneurysm was found on the left ICA paraclinoid portion. Under general anesthesia, a Pipeline Flex was inserted along with coil embolization. After treatment, the aneurysm showed thrombotic expansion, and the visual impairment worsened. One year later, aneurysm recanalization was evident; therefore, another Pipeline was inserted to overlap the stent. However, her visual impairment worsened again, and parent artery occlusion with high flow bypass was performed 20 months after her first treatment. Two weeks postoperatively, improved peripheral vision was confirmed. Further, no enlargement of the aneurysm was observed using magnetic resonance imaging 6 months later. CONCLUSION: This case examined a symptomatic, large paraclinoid aneurysm in a patient, which continued to enlarge after Pipeline stent placement, but was later treated successfully using direct parent artery occlusion in combination with high-flow bypass.
Effects of clazosentan on cerebral vasospasm-related morbidity and all-cause mortality after aneurysmal subarachnoid hemorrhage: two randomized phase 3 trials in Japanese patients. 国際誌

Hidenori Endo, Yasushi Hagihara, Naoto Kimura, Katsumi Takizawa, Kuniyasu Niizuma, Osamu Togo, Teiji Tominaga

Journal of neurosurgery　137　(6)　1-11　2022年4月1日

DOI： 10.3171/2022.2.JNS212914 　

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OBJECTIVE: Clazosentan has been investigated globally for the prevention of cerebral vasospasm after aneurysmal subarachnoid hemorrhage (aSAH). The authors evaluated its effects on vasospasm-related morbidity and all-cause mortality following aSAH in Japanese patients. METHODS: Two similar double-blind, placebo-controlled phase 3 studies were conducted in 57 Japanese centers in patients with aSAH, after aneurysms were secured by endovascular coiling in one study and surgical clipping in the other. In each study, patients were randomly administered intravenous clazosentan (10 mg/hr) or placebo (1:1) starting within 48 hours of aSAH and for up to 15 days after aSAH. Stratified randomization based on World Federation of Neurosurgical Societies grade was performed using a centralized interactive web response system. Vasospasm-related morbidity and all-cause mortality within 6 weeks post-aSAH, including new cerebral infarcts and delayed ischemic neurological deficits as well as all-cause mortality, were the first primary endpoint in each study. The second primary endpoint was all-cause morbidity (new cerebral infarct or delayed ischemic neurological deficit from any causes) and all-cause mortality (all-cause morbidity/mortality) within 6 weeks post-aSAH. The incidence of individual components of the primary morbidity/mortality endpoints within 6 weeks and patient outcome at 12 weeks post-aSAH (including the modified Rankin Scale scores) were also evaluated. The above analyses were also performed in the population pooled from both studies. RESULTS: In each study, 221 patients were randomized and 220 were included in the full analysis set of the primary analysis (109 in each clazosentan group, 111 in each placebo group). Clazosentan significantly reduced the incidence of vasospasm-related morbidity and all-cause mortality after aneurysm coiling (from 28.8% to 13.6%; relative risk reduction 53%; 95% CI 17%-73%) and after clipping (from 39.6% to 16.2%; relative risk reduction 59%; 95% CI 33%-75%). All-cause morbidity/mortality and poor outcome (dichotomized modified Rankin Scale scores) were significantly reduced by clazosentan after preplanned study pooling. Treatment-emergent adverse events were similar to those reported previously. CONCLUSIONS: Clazosentan significantly reduced the combined incidence of vasospasm-related morbidity and all-cause mortality post-aSAH with no unexpected safety findings. Clinical trial registration nos.: JapicCTI-163368 and JapicCTI-163369 (https://www.clinicaltrials.jp).
Wall enhancement in unruptured posterior communicating aneurysms with oculomotor nerve palsy on magnetic resonance vessel wall imaging. 国際誌

Shunsuke Omodaka, Hidenori Endo, Kuniyasu Niizuma, Toshiki Endo, Kenichi Sato, Atsushi Saito, Hiroki Uchida, Yasushi Matsumoto, Teiji Tominaga

Journal of neurosurgery　1-7　2022年1月21日

DOI： 10.3171/2021.11.JNS212249 　

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OBJECTIVE: Recent MR vessel wall imaging studies of unruptured intracranial aneurysms (UIAs) have revealed that aneurysm wall enhancement (AWE) can be an indicator for aneurysm evolution; however, the degree of AWE among different types of evolving UIAs has yet to be clarified. The authors assessed the degree of AWE in unruptured posterior communicating artery (PcomA) aneurysms with oculomotor nerve palsy (ONP), which may be a subgroup of evolving UIAs with rapid enlargement and high rupture risk. METHODS: The degree of AWE was analyzed in 35 consecutive evolving PcomA aneurysms (19 with and 16 without ONP). UIAs were considered to be evolving when showing growth or ONP. A 3D T1-weighted fast spin echo sequence was obtained after contrast media injection, and the contrast ratio of the aneurysm wall against the pituitary stalk (CRstalk) was calculated as the indicator of AWE. The CRstalk in evolving UIAs with ONP was compared with that in UIAs without ONP. RESULTS: The CRstalk was significantly higher in evolving UIAs with ONP than in those without ONP (0.85 vs 0.57; p = 0.006). In multivariable analysis, the CRstalk remained a significant indicator for ONP presentation in evolving UIAs (OR 6.13, 95% CI 1.21-31.06). CONCLUSIONS: AWE was stronger in evolving PcomA aneurysms with ONP than in those without ONP, suggesting the potential utility of AWE for risk stratification in evolving UIAs. The degree of AWE can be a promising indicator of a rupture-prone UIA, which can be useful information for the decision-making process in the treatment of UIAs.
Quantitative assessment of microstructural evolution of intracranial aneurysm wall by vessel wall imaging. 国際誌

Hidenori Endo, Naoko Mori, Shunji Mugikura, Kuniyasu Niizuma, Shunsuke Omodaka, Kei Takase, Teiji Tominaga

Neuroradiology　64　(7)　1343-1350　2022年1月8日
出版者・発行元： Springer Science and Business Media {LLC}
DOI： 10.1007/s00234-021-02877-7 　

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PURPOSE: This study aimed to evaluate new quantitative parameters of aneurysm wall enhancement (AWE) on magnetic resonance vessel wall imaging (VWI) in differentiating between the stable and evolving unruptured intracranial aneurysms (UIAs). METHODS: Thirty-eight consecutive patients with UIAs (27 stable and 11 evolving) underwent VWI with contrast-enhanced 3D T1 volume isotropic turbo spin echo acquisition. The voxel-based enhancement maps were created using pre- and post-contrast images. The aneurysmal lumen with signal suppression by black-blood method was segmented. Then, one voxel outer and inner layers of the lumen contour were automatically segmented. The shape features of the aneurysms and AWE of the two layers were compared between stable and evolving groups. RESULTS: The shape features, including aneurysm volume, surface, and compacity were significantly different between the stable and evolving groups (P = 0.024, 0.028, and 0.033, respectively). Stable and evolving groups also differed significantly in the AWE at the union of outer and inner layers of the aneurysm wall (P = 0.0082) but not in that of the outer or inner layer alone. Multivariate logistic regression analysis revealed significant differences in aneurysm volume, surface, and AWE at the union of outer and inner layers between the two groups (P = 0.0029, 0.0092, and 0.0033, respectively). Receiver operating characteristics curve analysis revealed that the area under the curve of the logistic regression model was 0.89. CONCLUSION: Quantitative combined analysis of aneurysm shape features and AWE of the union of outer and inner layers were effective for differentiating between stable and evolving UIAs.
Efficacy of arterial spin labeling for detection of the ruptured micro-arteriovenous malformation: illustrative cases. 国際誌

Ryuzaburo Kochi, Hidenori Endo, Hiroki Uchida, Tomohiro Kawaguchi, Shunsuke Omodaka, Yasushi Matsumoto, Teiji Tominaga

Journal of neurosurgery. Case lessons　3　(1)　2022年1月3日

DOI： 10.3171/CASE21597 　

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BACKGROUND: Diagnosis of a microarteriovenous malformation (micro-AVM) is difficult, especially in the acute stage of rupture because of the small size of the nidus and the existence of hematoma. We report two cases of ruptured micro-AVMs detected by arterial spin labeling (ASL). OBSERVATIONS: In one case, a 45-year-old male was transported with a complaint of right hemiparesis. Computed tomography (CT) revealed a right parietal lobar hemorrhage. Standard magnetic resonance imaging (MRI) showed no abnormal findings as the cause of the hemorrhage. ASL 23 days after the onset demonstrated high signals on the medial wall of the hematoma. Digital subtraction angiography (DSA) showed a micro-AVM in accordance with the site of high signals on ASL. In another case, a 38-year-old female was transported with a complaint of left hemianopsia. CT on admission revealed a right parietal lobar hemorrhage. Standard MRI showed no abnormal findings as the cause of the hemorrhage. ASL 15 days after the onset demonstrated high signals on the internal wall of the hematoma. DSA showed micro-AVM in accordance with the site of high signaling on ASL. Both cases were successfully treated with open surgery. LESSONS: ASL can manifest micro-AVMs as high signals within the hematoma. ASL is a useful less-invasive screening tool for the detection of ruptured micro-AVMs.
Association between RNF213 c.14576G>A Variant (rs112735431) and Peripheral Pulmonary Artery Stenosis in Moyamoya Disease. 国際誌

Dan Ozaki, Hidenori Endo, Ryosuke Tashiro, Koichiro Sugimura, Shunsuke Tatebe, Satoshi Yasuda, Yasutake Tomata, Toshiki Endo, Keita Tominaga, Kuniyasu Niizuma, Miki Fujimura, Teiji Tominaga

Cerebrovascular diseases (Basel, Switzerland)　51　(3)　282-287　2022年
出版者・発行元： S. Karger {AG}
DOI： 10.1159/000519717 　

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BACKGROUND: Moyamoya disease (MMD) and peripheral pulmonary artery stenosis (PPAS) are relatively rare and demonstrate steno-occlusive vascular lesions in different organs. Genetic studies identified RNF213 polymorphism c.14576G>A (rs112735431) as a susceptibility variant for East Asian MMD. RNF213 polymorphism c.14576G>A is further associated with various vascular lesions of other organs. In this study, we aimed to clarify the incidence and clinical manifestations of PPAS in MMD patients and analyze the correlation between RNF213 genotype and PPAS. METHODS: This retrospective case-control study investigated the association between RNF213 polymorphism and PPAS in 306 MMD/quasi-MMD patients, reviewing the medical charts and imaging records of consecutive patients with MMD admitted from January 2015 to December 2020. RESULTS: PPAS was observed in 3 MMD/quasi-MMD patients (0.98%, 3/306). RNF213 polymorphism c.14576G>A was determined for all 306 MMD/quasi-MMD patients. The incidence of PPAS in RNF213-wildtype, RNF213-heterozygote, and RNF213-homozygote MMD/quasi-MMD patients was 0% (0/101), 0.5% (1/200), and 40% (2/5), respectively. The association between PPAS and homozygote polymorphism of RNF213 c.14576G>A was statistically significant in MMD/quasi-MMD patients (p = 0.0018). In all cases, pulmonary artery hypertension due to PPAS was evident during their childhood and young adolescent stages. Surgical indications for MMD were discouraged in 1 case due to her severe cardiopulmonary dysfunction. CONCLUSIONS: The homozygote variant of RNF213 polymorphism c.14576G>A can be a potential predisposing factor for PPAS in MMD/quasi-MMD patients. Despite the relatively rare entity, PPAS should be noted to determine surgical indications for MMD/quasi-MMD patients.
Direct carotid puncture for endovascular surgery of intracranial aneurysms: Technical note for avoiding complications. 国際誌

Takatsugu Abe, Hiroyuki Sakata, Masayuki Ezura, Hidenori Endo, Teiji Tominaga

Surgical neurology international　13　69-69　2022年

DOI： 10.25259/SNI_1147_2021 　

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BACKGROUND: While the most intracranial aneurysms are approachable by femoral or brachial artery puncture during endovascular surgery, in some cases, the lesion is difficult to reach due to complications such as the presence of winding pathways. Direct carotid puncture (DCP) is an alternative access approach, despite the potential risk of fatal neck hematoma. Herein, we describe the DCP technique in a series of five patients with intracranial aneurysms, together with its technical considerations. METHODS: Patients with intracranial aneurysms who underwent endovascular surgery using DCP were reviewed retrospectively. We selected the 3F to 6F systems for DCP depending on the necessity of adjunctive techniques. To prevent DCP-associated complications, we (1) conducted a micropuncture before introducing the short sheaths,(2) selected the smallest possible size for the system, (3) reversed heparin postoperatively, and (4) performed perioperative intubation/sedation management. RESULTS: Five out of 535 patients underwent DCP in our hospital between 2015 and 2019; successful vascular access was achieved in all cases. Although a minor neck hematoma occurred in one case, the patient did not require additional treatment. According to a literature review, severe neck hematoma requiring rescue therapy occurs in 5 out of 95 cases (5.3%). CONCLUSION: Although the potential risk of neck hematoma is not negligible, the DCP technique appears to be a safe and effective approach in treating intracranial aneurysms with challenging access routes in cases where perioperative counter measurements are appropriately performed.
高齢者における各種疾患コンセプト高齢者に対する機械的血栓回収療法の現状

坂田洋之, 江面正幸, 石田朋久, 遠藤英徳, 井上敬, 斉藤敦志, 上之原広司, 冨永悌二

Geriatric Neurosurgery　34　9-12　2021年11月
出版者・発行元：日本老年脳神経外科学会
ISSN：1343-4233

eISSN：2436-6064

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過去12年間の機械的血栓回収術症例67例を80歳以上の高齢者群21例(平均年齢86.0歳)と80歳未満の非高齢者群46例(平均年齢66.3歳)に分けて比較した。高齢者群は有意に女性の割合が高かった。両群の閉塞血管の分布は同等で、術前のt-PA静注は高齢者で多い傾向であった。両群の有効再開通率は同等であったが、高齢者群は有意なpuncture to recanalization time延長を認め、転帰不良例が多かった。
Computational hemodynamic analysis of the offending vertebral artery at the site of neurovascular contact in a case of hemifacial spasm associated with subclavian steal syndrome: illustrative case. 国際誌

Keita Tominaga, Hidenori Endo, Shin-Ichiro Sugiyama, Shin-Ichiro Osawa, Kuniyasu Niizuma, Teiji Tominaga

Journal of neurosurgery. Case lessons　2　(12)　CASE21447　2021年9月20日

DOI： 10.3171/CASE21447 　

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BACKGROUND: Hemifacial spasm (HFS) is caused by neurovascular contact along the facial nerve's root exit zone (REZ). The authors report a rare HFS case that was associated with ipsilateral subclavian steal syndrome (SSS). OBSERVATIONS: A 42-year-old man with right-sided aortic arch presented with progressing left HFS, which was associated with ipsilateral SSS due to severe stenosis of the left brachiocephalic trunk. Magnetic resonance imaging showed contact between the left REZ and vertebral artery (VA), which had shifted to the left. The authors speculated that the severe stenosis at the left brachiocephalic trunk resulted in the left VA's deviation, which was the underlying cause of the HFS. The authors performed percutaneous angioplasty (PTA) to dilate the left brachiocephalic trunk. Ischemic symptoms of the left arm improved after PTA, but the HFS remained unchanged. A computational fluid dynamics study showed that the high wall shear stress (WSS) around the site of neurovascular contact decreased after PTA. In contrast, pressure at the point of neurovascular contact increased after PTA. LESSONS: SSS is rarely associated with HFS. Endovascular treatment for SSS reduced WSS of the neurovascular contact but increased theoretical pressure of the neurovascular contact. Physical release of the neurovascular contact is the best treatment option for HFS.
Arteriovenous malformation of the trigeminal nerve root presented with venous congestive edema of the medulla oblongata and upper cervical cord: illustrative case. 国際誌

Arata Nagai, Hidenori Endo, Kenichi Sato, Tomohiro Kawaguchi, Hiroki Uchida, Shunsuke Omodaka, Yasushi Matsumoto, Teiji Tominaga

Journal of neurosurgery. Case lessons　2　(9)　CASE21402　2021年8月30日

DOI： 10.3171/CASE21402 　

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BACKGROUND: Arteriovenous malformation (AVM) of the trigeminal nerve root (TNR) is a rare subtype of the lateral pontine AVM. Most of them are diagnosed when they bleed or exert trigeminal neuralgia. Venous congestive edema is a rare phenomenon caused by TNR AVMs. OBSERVATIONS: An 82-year-old man was admitted with progressive limb weakness and dysphasia. Magnetic resonance imaging (MRI) revealed extensive edema of the medulla oblongata and the upper cervical cord with signal flow void at the C3 anterior spinal cord. Vertebral angiography revealed a small nidus fed mainly by the pontine perforating arteries (PPAs). The anterior pontomesencephalic vein (AMPV) was dilated, functioning as the main drainage route. This suggests that venous hypertension triggered the brainstem and upper cervical cord edema. MRI with gadolinium enhancement showed that the nidus was located around the right TNR. Because the nidus sat extrinsically on the pial surface of the right TNR's base, microsurgical obliteration with minimum parenchymal injury was achieved. Postoperative MRI showed disappearance of the brainstem and cervical cord edema with improved clinical symptoms. LESSONS: TNR AVM is rarely associated with brainstem and upper cervical cord edema caused by venous hypertension of the congestive drainage system.
Digital intravascular pressure wave recording during endovascular treatment reveals abnormal shunting flow in vertebral venous fistula of the vertebral artery: illustrative case. 国際誌

Yoshiteru Shimoda, Shinya Sonobe, Kuniyasu Niizuma, Toshiki Endo, Hidenori Endo, Mayuko Otomo, Teiji Tominaga

Journal of neurosurgery. Case lessons　2　(2)　CASE21172　2021年7月12日

DOI： 10.3171/CASE21172 　

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BACKGROUND: An arteriovenous fistula is an abnormal arteriovenous shunt between an artery and a vein, which often leads to venous congestion in the central nervous system. The blood flow near the fistula is different from normal artery flow. A novel method to detect the abnormal shunting flow or pressure near the fistula is needed. OBSERVATIONS: A 76-year-old woman presented to the authors' institute with progressive right upper limb weakness. Right vertebral angiography showed a fistula between the right extracranial vertebral artery (VA) and the right vertebral venous plexus at the C7 level. The patient underwent endovascular treatment for shunt flow reduction. Before the procedure, blood pressures were measured at the proximal VA, distal VA near the fistula, and just at the fistula and drainer using a microcatheter. The blood pressure waveforms were characteristically different in terms of resistance index, half-decay time, and appearance of dicrotic notch. The fistula was embolized with coils and N-butyl cyanoacrylate solution. LESSONS: During endovascular treatment, the authors were able to digitally record the vascular pressure waveform from the tip of the microcatheter and succeeded in calculating several parameters that characterize the shunting flow. Furthermore, these parameters could help recognize the abnormal blood flow, allowing a safer endovascular surgery.
エンボスフィアを用いた経動脈的塞栓で根治し得た海綿静脈洞部硬膜動静脈瘻の1例

陳梦格, 大沢伸一郎, 新妻邦泰, 遠藤英徳, 冨永悌二

脳血管内治療　6　(1)　38-43　2021年5月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN：2423-9119

eISSN：2424-1709
Carotid artery stenting in a patient with an incidentally found double aortic arch: A case report. 国際誌

Yuki Kitamura, Hiroyuki Sakata, Masayuki Ezura, Tomohisa Ishida, Hidenori Endo, Takashi Inoue, Teiji Tominaga

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences　27　(5)　15910199211001717-15910199211001717　2021年3月5日
出版者・発行元： {SAGE} Publications
DOI： 10.1177/15910199211001717 　

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Double aortic arch is a type of congenital vascular ring, which rarely presents in adults. Herein, we report a case of carotid artery stenting (CAS) accompanied by an incidentally found double aortic arch. A 77-year-old man presented with bilateral severe carotid artery stenosis. The patient underwent truncal 3D-computed tomography angiography (CTA) to evaluate the access route before CAS, which lead to the diagnosis of an asymptomatic double aortic arch. Referring to the 3D-CTA images, a guiding catheter was successfully navigated to the targeted common carotid artery via the transfemoral approach despite the challenging, complex anatomy of the aortic arch. CAS was performed in both carotid arteries under distal balloon protection, without any neurological deficits. Considering the possible presence of anatomical variants such as double aortic arch, preoperative evaluation of the access route would be efficient for prospective CAS patients.
[Subarachnoid Hemorrhage].

Hidenori Endo, Miki Fujimura, Teiji Tominaga

No shinkei geka. Neurological surgery　49　(2)　220-228　2021年3月

DOI： 10.11477/mf.1436204382 　

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Intracranial aneurysms or arterial dissections are major causes of subarachnoid hemorrhage(SAH). Early surgical or endovascular repair of the bleeding source is crucial because rebleeding mostly occurs within a few days after the initial attack. Radiological examination is an initial step for the appropriate diagnosis of ruptured intracranial aneurysms and arterial dissections. However, misdiagnosis may occur, especially in patients with minor bleeding or multiple aneurysms. In addition to computed tomography, magnetic resonance imaging, including FLAIR and SWI, and T2*WI are useful for detecting minor SAH. Vessel-wall imaging has recently been applied to diagnosing the site of rupture in patients with multiple cerebral aneurysms or microaneurysms, but not to assessing the instability of unruptured cerebral aneurysms or intracranial arterial dissections. In this article, we discuss the current radiological modalities and their usefulness for diagnosing SAH.
Effect of endoscope flexibility on tissue dissection profile assessed with pulsed water jet device: ensuring safety, efficacy, and handling of thin devices for neuroendoscopic surgery. 国際誌

Tetsuya Kusunoki, Tomohiro Kawaguchi, Atsuhiro Nakagawa, Yuta Noguchi, Shin-Ichiro Osawa, Hidenori Endo, Toshiki Endo, Ryuta Saito, Masayuki Kanamori, Kuniyasu Niizuma, Teiji Tominaga

BMC research notes　14　(1)　64-64　2021年2月17日

DOI： 10.1186/s13104-021-05475-1 　

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OBJECTIVE: We developed an actuator-driven pulsed water jet device (ADPJ) for flexible neuroendoscopy to achieve effective tissue dissection with vasculature preservation. Although flexibility is a strong advantage for minimally invasiveness, the effect of the ductile curvature on the dissection profiles remains unknown. The purpose of this study was to clarify the impact of the curvature change of the ADPJ connecting tube on the dissection safety and efficacy. RESULTS: Three ADPJ connecting tubes with different inner diameters (1.0, 0.75, 0.5 mm) were used to dissect the brain phantom. They were bent at 3 angles: 0°, 60°, and 120°. The dissection profiles were evaluated using the mean depth and coefficient of variation (CV) for efficacy and safety, respectively.The larger inner diameter connecting tube dissected more deeply. The dissection depth was not changed regardless of the curvature degree in each tube. There was no significant difference in CVs regardless of inner diameter and curvature. The ductile curvature of the flexible neuroendoscope did not affect the efficacy and safety of the ADPJ dissection profile. Among the numerous instruments, tube-formed devices, including suction and injecting devices such as ADPJ, can be used safely and effectively without flexibility-related limitations.
Brain Temperature Measured by Magnetic Resonance Spectroscopy to Predict Clinical Outcome in Patients with Infarction. 国際誌

Tomohisa Ishida, Takashi Inoue, Tomoo Inoue, Toshiki Endo, Miki Fujimura, Kuniyasu Niizuma, Hidenori Endo, Teiji Tominaga

Sensors (Basel, Switzerland)　21　(2)　2021年1月12日

DOI： 10.3390/s21020490 　

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Acute ischemic stroke is characterized by dynamic changes in metabolism and hemodynamics, which can affect brain temperature. We used proton magnetic resonance (MR) spectroscopy under everyday clinical settings to measure brain temperature in seven patients with internal carotid artery occlusion to explore the relationship between lesion temperature and clinical course. Regions of interest were selected in the infarct area and the corresponding contralateral region. Single-voxel MR spectroscopy was performed using the following parameters: 2000-ms repetition time, 144-ms echo time, and 128 excitations. Brain temperature was calculated from the chemical shift between water and N-acetyl aspartate, choline-containing compounds, or creatine phosphate. Within 48 h of onset, compared with the contralateral region temperature, brain temperature in the ischemic lesion was lower in five patients and higher in two patients. Severe brain swelling occurred subsequently in three of the five patients with lower lesion temperatures, but in neither of the two patients with higher lesion temperatures. The use of proton MR spectroscopy to measure brain temperature in patients with internal carotid artery occlusion may predict brain swelling and subsequent motor deficits, allowing for more effective early surgical intervention. Moreover, our methodology allows for MR spectroscopy to be used in everyday clinical settings.
Intentional Stent Herniation Technique Using Neuroform Atlas Stent System for Embolization of a Wide-Necked Basilar Tip Aneurysm

Hiroyuki Sakata, Masayuki Ezura, Takatsugu Abe, Tomohisa Ishida, Hidenori Endo, Takashi Inoue, Toshiki Endo, Hiroshi Uenohara, Teiji Tominaga

Journal of Neuroendovascular Therapy　15　(12)　823-828　2021年
出版者・発行元： The Japanese Society for Neuroendovascular Therapy
DOI： 10.5797/jnet.tn.2020-0155 　

ISSN：1882-4072

eISSN：2186-2494
Comparison between ultra-high-resolution computed tomographic angiography and conventional computed tomographic angiography in the visualization of the subcallosal artery. 国際誌

Yoshimichi Sato, Toshiki Endo, Shingo Kayano, Hitoshi Nemoto, Kazuki Shimada, Akira Ito, Hidenori Endo, Shunji Mugikura, Kuniyasu Niizuma, Teiji Tominaga

Surgical neurology international　12　528-528　2021年

DOI： 10.25259/SNI_887_2021 　

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BACKGROUND: The subcallosal artery (ScA) is a single dominant artery arising from the anterior communicating artery. Its injury causes amnesia and cognitive disturbance. The conventional computed tomographic angiography (C-CTA) is a common evaluation method of the intracranial artery. However, to image tinny perforating arteries such as the ScA is technically demanding for C-CTA. The purpose of this study is to investigate whether the ultra-high-resolution CTA (UHR-CTA) could image the ScA better than C-CTA. UHR-CTA became available in clinical practice in 2017. Its novel features are the improvement of the detector system and a small X-ray focus. METHODS: Between April 2019 and May 2020, 77 and 49 patients who underwent intracranial UHR-CTA and C-CTA, respectively, were enrolled in this study. Two board-certified neurosurgeons participated as observers to identify the ScA based on UHR-CTA and C-CTA images. RESULTS: UHR-CTA and C-CTA detected the ScA in 56-58% and 30-40% of the patients, respectively. In visualization of the ScA, UHR-CTA was better than C-CTA (P < 0.05, Fisher's exact test). Between the two observers, the Cohen's kappa coefficient was 0.77 for UHR-CTA and 0.78 for C-CTA. CONCLUSIONS: UHR-CTA is a simple and accessible method to evaluate intracranial vasculature. Visualization of the ScA with UHR-CTA was better than that with C-CTA. The high quality of UHR-CTA could provide useful information in the neurosurgery field.
Basilar artery dissection with rupture 6 years after accidental detection: A case report. 国際誌

Yoshimichi Sato, Kuniyasu Niizuma, Hideki Ota, Hidenori Endo, Teiji Tominaga

Surgical neurology international　12　4-4　2021年

DOI： 10.25259/SNI_735_2020 　

ISSN：2152-7806
Ocular neuromyotonia caused by a recurrent sphenoidal ridge meningioma. 国際誌

Yuto Shingai, Hidenori Endo, Toshiki Endo, Shin-Ichiro Osawa, Kuniyasu Nizuma, Teiji Tominaga

Surgical neurology international　12　219-219　2021年

DOI： 10.25259/SNI_38_2021 　

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Background: Ocular neuromyotonia (ONM) is a rare ocular motility disorder characterized by involuntary paroxysmal extraocular muscle contraction and is caused by radiation therapy, vascular compression, and inflammatory disease. This study includes a rare case of ONM caused by a recurrent meningioma. Case Description: A 56-year-old man presented with diplopia due to the right oculomotor nerve palsy caused by a sphenoidal atypical meningioma, with improved symptoms after initial surgery. During the next 7 years, he underwent local radiation therapy, second surgery, and Gamma Knife radiosurgery to control the tumor's repetitive recurrence around the right anterior clinoid process. After these treatments, residual tumor was controlled for the next 3 years. However, 3 months after his last visit, he started to suffer from the right ONM and visual disturbance. The magnetic resonance imaging results revealed a rapid growth of the posterior part of the residual tumor, involving the right oculomotor nerve. The third tumor resection was performed to prevent further aggravation of the symptoms. Decompression of the right oculomotor nerve was achieved, and ONM disappeared immediately after surgery. Conclusion: If nerve compression by the tumor is clearly indicated with the neuroradiological assessment, surgical intervention is the treatment of choice to improve ONM.
Efficacy of arterial spin labeling magnetic resonance imaging with multiple post-labeling delays to predict postoperative cerebral hyperperfusion in carotid endarterectomy. 国際誌

Hidenori Endo, Miki Fujimura, Atsushi Saito, Toshiki Endo, Kazumasa Ootomo, Teiji Tominaga

Neurological research　43　(3)　1-7　2020年11月15日

DOI： 10.1080/01616412.2020.1847529 　

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Introduction: Cerebral hyperperfusion (CHP) syndrome is one of the most deleterious complications after carotid endarterectomy (CEA). Arterial spin labeling (ASL) is a promising non-invasive method to evaluate various hemodynamic parameters in cerebrovascular diseases. The aim of this study was to clarify whether ASL with multiple post-labeling delays (PLDs) can predict postoperative CHP after CEA. Methods: Sixty-one patients with carotid artery stenosis treated by CEA were retrospectively analyzed. The asymmetry index of the preoperative CBF was obtained from ASL using 3 PLDs (1525 ms, 2025 ms, and 2525 ms) and single-photon emission computed tomography (SPECT). Cerebrovascular reactivity (CVR) was measured from SPECT with acetazolamide challenge. The slope of the regression line obtained from the asymmetry index of three PLDs was defined as the slope index. Results: The CHP phenomenon was observed in seven patients (11.5%), one of whom developed CHP syndrome (1.6%). Using the CHP phenomenon as a reference standard, the area under the receiver operating characteristics (ROC) was 0.68 for the asymmetry index of the preoperative SPECT, 0.71 for the asymmetry index of the preoperative ASL,0.73 for CVR, and 0.78 for the slope index. Using the cutoff value obtained by ROC analysis, the slope index demonstrated a sensitivity of 85%, specificity of 74%, positive predictive value of 30% and the negative predictive value of 98% for predicting CHP. Conclusions: The slope index calculated by ASL with multiple PLDs is a useful screening tool to predict postoperative CHP after CEA.
2D perfusion angiographyを用いた頸動脈ステント留置術後の過灌流予測

坂田洋之, 江面正幸, 石田朋久, 阿部考貢, 井上敬, 遠藤英徳, 遠藤俊毅, 上之原広司, 冨永悌二

脳循環代謝　32　(1)　74-74　2020年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN：0915-9401

eISSN：2188-7519
脳動脈瘤は無症候性脳梗塞発症のリスクファクター

井上敬, 遠藤英徳, 坂田洋之, 石田朋久, 江面正幸, 上之原広司, 冨永悌二

脳循環代謝　32　(1)　79-79　2020年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN：0915-9401

eISSN：2188-7519
Risk factors for medullary infarction after endovascular trapping of vertebral artery dissecting aneurysms. 国際誌

Hidenori Endo, Shuichi Tanoue, Masafumi Hiramatsu, Yasushi Matsumoto, Kenichi Sato, Masayuki Sato, Yuji Matsumaru, Wataro Tsuruta, Hiro Kiyosue

Neurosurgical review　44　(4)　2283-2290　2020年10月21日

DOI： 10.1007/s10143-020-01424-x 　

ISSN：1437-2320 0344-5607
Delineability and anatomical variations of perforating arteries from normal vertebral artery on 3D DSA: implications for endovascular treatment of dissecting aneurysms. 国際誌

Shuichi Tanoue, Hidenori Endo, Masafumi Hiramatsu, Yuji Matsumaru, Yasushi Matsumoto, Kenichi Sato, Wataro Tsuruta, Masayuki Sato, Masaru Hirohata, Toshi Abe, Hiro Kiyosue

Neuroradiology　63　(4)　609-617　2020年9月21日

DOI： 10.1007/s00234-020-02549-y 　

ISSN：1432-1920 0028-3940
Clinical utility of apparent diffusion coefficient and diffusion‐weighted magnetic resonance imaging for resectability assessment of head and neck tumors with skull base invasion 査読有り

Takenori Ogawa, Ikuho Kojima, Shun Wakamori, Takuya Yoshida, Takaki Murata, Maya Sakamoto, Akira Ohkoshi, Ayako Nakanome, Hidenori Endo, Toshiki Endo, Hajime Usubuchi, Yukio Katori

Head & Neck　42　(10)　2020年7月
出版者・発行元： Wiley
DOI： 10.1002/hed.26336 　

ISSN：1043-3074

eISSN：1097-0347
Focal Cerebellar Hyperperfusion After Bypass Surgery for Vertebrobasilar Ischemia: Effect of Cerebrovascular Reactivity as Potential Predictor of Hyperperfusion. 国際誌査読有り

Hidenori Endo, Miki Fujimura, Taketo Nishizawa, Atsushi Saito, Teiji Tominaga

World neurosurgery　140　101-106　2020年5月16日

DOI： 10.1016/j.wneu.2020.05.069 　

ISSN：1878-8769 1878-8750
医局長クラスが語る、脳神経外科医の「働き方改革」(後編)(Case Study編) 査読有り

大宅宗一, 荒川芳輝, 榎本由貴子, 遠藤英徳, 菱川朋人, 安田宗義

脳神経外科速報　30　(5)　490-497　2020年5月
出版者・発行元： (株)メディカ出版
ISSN：0917-1495
Symptomatic Cerebral Hyperperfusion After Cerebral Vasospasm Associated with Aneurysmal Subarachnoid Hemorrhage. 国際誌査読有り

Hiroyuki Sakata, Hidenori Endo, Miki Fujimura, Kuniyasu Niizuma, Teiji Tominaga

World neurosurgery　137　379-383　2020年5月

DOI： 10.1016/j.wneu.2020.02.092 　

ISSN：1878-8769 1878-8750
Optimal Timing of Extracranial-Intracranial Bypass with Microsurgical Trapping for Ruptured Blister Aneurysms of the Internal Carotid Artery. 国際誌査読有り

Hidenori Endo, Miki Fujimura, Hiroaki Shimizu, Toshiki Endo, Shunsuke Omodaka, Takashi Inoue, Kenichi Sato, Kuniyasu Niizuma, Teiji Tominaga

World neurosurgery　136　e567-e577　2020年4月

DOI： 10.1016/j.wneu.2020.01.081 　

ISSN：1878-8769 1878-8750
Octacalcium phosphate collagen composite (OCP/Col) enhance bone regeneration in a rat model of skull defect with dural defect. 国際誌査読有り

Takashi Sasaki, Kuniyasu Niizuma, Atsushi Kanoke, Keiko Matsui, Shogo Ogita, Sherif Rashad, Tadashi Kawai, Mika Watanabe, Hidenori Endo, Tetsu Takahashi, Shinji Kamakura, Teiji Tominaga

Heliyon　6　(2)　e03347　2020年2月

DOI： 10.1016/j.heliyon.2020.e03347 　

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Cranial bone defects are a major issue in the field of neurosurgery, and improper management of such defects can cause cosmetic issues as well as more serious infections and inflammation. Several strategies exist to manage these defects clinically, but most rely on synthetic materials that are prone to complications; thus, a bone regenerative approach would be superior. We tested a material (octacalcium phosphate collagen composite [OCP/Col]) that is known to enhance bone regeneration in a skull defect model in rats. Using a critical-sized rat skull defect model, OCP/Col was implanted in rats with an intact dura or with a partial defect of the dura. The results were compared with those in a no-treatment group over the course of 12 weeks using computed tomographic and histological analysis. OCP/Col enhanced bone regeneration, regardless of whether there was a defect of the dura. OCP/Col can be used to treat skull defects, even when the dura is injured or removed surgically, via bone regeneration with enhanced resorption of OCP/Col, thus limiting the risk of infection greatly.
Future potential and challenges of aneurysm surgery

Endo, H., Sato, K., Sugiyama, S.-I., Fujimura, M., Tominaga, T.

Japanese Journal of Neurosurgery　29　(2)　2020年

DOI： 10.7887/jcns.29.86 　

ISSN：0917-950X
Efficacy of intra-arterial indocyanine green angiography for the microsurgical treatment of dural arteriovenous fistula: A case report. 国際誌査読有り

Keisuke Sasaki, Hidenori Endo, Kuniyasu Niizuma, Yasuo Nishijima, Shinichiro Osawa, Miki Fujimura, Teiji Tominaga

Surgical neurology international　11　46-46　2020年

DOI： 10.25259/SNI_588_2019 　

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Background: In this study, we report a case of dural arteriovenous fistula (dAVF) that was successfully treated using intra-arterial indocyanine green (IA-ICG) videoangiography during open surgery. Moreover, the findings of IA-ICG videoangiography were compared with those of intraoperative digital subtraction angiography (DSA). Case Description: A 72-year-old male patient with a history of hypertension, hyperlipidemia, and thrombocytosis presented with generalized seizure. DSA revealed Cognard Type III dAVF in the superior wall of the left transverse sinus, which was fed by a single artery (the left occipital artery [OA]) and drained into a single vein (the left temporal cortical vein), without drainage into a venous sinus. Since transarterial embolization was considered challenging due to the tortuosity of the left OA, surgical interruption of the shunt was performed by craniotomy. After excising the feeding artery, we were unable to observed dAVF on intraoperative DSA. However, IA-ICG videoangiography revealed the remaining shunt, which was fed by the collateral route from the feeding artery. The shunting point and draining vein were then surgically resected to eliminate the shunt. The shunt was not observed during the second IA-ICG videoangiography conducted after resection. Conclusion: ICG videoangiography is a better method compared with DSA in terms of visualizing fine vascular lesions. In contrast to the typical intravenous administration, selective IA-ICG can be repeatedly injected at a minimal dose. IA-ICG is a useful intraoperative tool that can be used to evaluate the elimination of the dAVF.
Significance of Quantitative Cerebral Blood Flow Measurement in the Acute Stage after Revascularization Surgery for Adult Moyamoya Disease: Implication for the Pathological Threshold of Local Cerebral Hyperperfusion. 国際誌査読有り

Kameyama M, Fujimura M, Tashiro R, Sato K, Endo H, Niizuma K, Mugikura S, Tominaga T

Cerebrovascular diseases (Basel, Switzerland)　48　(3-6)　217-225　2020年1月

DOI： 10.1159/000504835 　

ISSN：1015-9770
Neuro-endoscopic management of hemorrhagic moyamoya disease in the acute stage: single institute experience. 国際誌査読有り

Mino M, Fujimura M, Endo H, Endo T, Sato K, Tominaga T

Neurological research　41　(12)　1097-1103　2019年12月

DOI： 10.1080/01616412.2019.1674006 　

ISSN：0161-6412
Enlargement of a Middle Cerebral Artery Aneurysm after Intra-Aneurysmal Embolization with Parent Artery Preservation for an Ipsilateral Large Internal Carotid Artery Aneurysm: A Case Report. 国際誌査読有り

Shenoy VS, Fujimura M, Saito A, Sato K, Matsumoto Y, Sugiyama SI, Endo H, Tominaga T

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association　29　(2)　104550-104550　2019年12月

DOI： 10.1016/j.jstrokecerebrovasdis.2019.104550 　

ISSN：1052-3057
Diagnostic Value of Contrast-Enhanced Magnetic Resonance Vessel Wall Imaging on the Onset Type of Vertebral Artery Dissection. 国際誌査読有り

Saito A, Fujimura M, Endo H, Omodaka S, Kanoke A, Sato K, Tominaga T

Cerebrovascular diseases (Basel, Switzerland)　48　(3-6)　1-8　2019年11月

DOI： 10.1159/000503852 　

ISSN：1015-9770
Genetic analysis of ring finger protein 213 (RNF213) c.14576G>A polymorphism in patients with vertebral artery dissection: a comparative study with moyamoya disease. 国際誌査読有り

Ryosuke Tashiro, Miki Fujimura, Hiroyuki Sakata, Hidenori Endo, Yasutake Tomata, Mika Sato-Maeda, Kuniyasu Niizuma, Teiji Tominaga

Neurological research　41　(9)　811-816　2019年9月

DOI： 10.1080/01616412.2019.1615726 　

ISSN：0161-6412

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Background: Intracranial vertebral artery dissection (VAD) and moyamoya disease (MMD) are rare cerebrovascular diseases, both of which have an ethnic predominance in the East Asian population. Disruption of the internal elastic lamina and subsequent rupture of the medial layer result in intracranial VAD. MMD is a chronic occlusive cerebrovascular disease of unknown etiology, in which the medial layer and internal elastic lamina of the intracranial arteries are significantly compromised. Recent genetic studies found ring finger protein 213 (RNF213) to be an important susceptibility gene for MMD in East Asian patients, but the association between VAD and RNF213 has not been investigated. . Methods: We investigated polymorphism of the RNF213 gene (c.14576G>A) in genomic DNA of 24 patients with intracranial VAD in comparison with 58 patients with definitive MMD and 48 healthy controls. Results: Although RNF213 gene polymorphism (c.14576G>A) was evident in 69% of the MMD patients (40/58), none of the patients with intracranial VAD had this characteristic polymorphism (0/24, p < 0.001). The incidence of RNF213 c.14576G>A polymorphism was 4.2% in healthy controls (2/48). After adjustment by age and sex, the incidence of RNF213 c.14576G>A was significantly lower in intracranial VAD patients (p = 0.021) than that in MMD patients. Conclusions: In contrast to MMD patients, the prevalence of RNF213 c.14576G>A polymorphism was significantly lower in patients with intracranial VAD. The RNF213 gene polymorphism may preferentially affect the cerebrovascular lesion in the anterior circulation, which is originated from the primitive internal carotid arteries. The genetic background underlying intracranial VAD should be elucidated in future studies. Abbreviations: VAD: vertebral artery dissection; MMD: moyamoya disease; RNF213: ring finger protein 213; CAD: carotid artery dissection.
Coexistence of Intracranial Germ Cell Tumor with Growing Arteriovenous Fistula. 国際誌査読有り

Ishida T, Endo H, Saito R, Kanamori M, Sato K, Matsumoto Y, Endo T, Fujimura M, Tominaga T

World neurosurgery　127　126-130　2019年7月

DOI： 10.1016/j.wneu.2019.04.015 　

ISSN：1878-8750
Tailor-Made Branch Reconstruction by Intracranial to Intracranial Bypass During Clipping Surgery for Middle Cerebral Artery Aneurysms. 査読有り

Sato K, Endo H, Fujimura M, Endo T, Shimizu H, Tominaga T

World neurosurgery　127　e1152-e1158　2019年7月
出版者・発行元：
DOI： 10.1016/j.wneu.2019.04.074 　

ISSN：1878-8750
Efficacy of Direct Revascularization Surgery for Hemorrhagic Moyamoya Syndrome As a Late Complication of Cranial Irradiation for Childhood Craniopharyngioma 査読有り

Kato, Y., Fujimura, M., Sato, K., Endo, H., Tominaga, T.

Journal of Stroke and Cerebrovascular Diseases　28　(5)　e46-e50　2019年5月
出版者・発行元： Elsevier {BV}
DOI： 10.1016/j.jstrokecerebrovasdis.2019.01.033 　

ISSN：1532-8511 1052-3057
Clipping of an anterior spinal artery aneurysm using an endoscopic fluorescence imaging system for craniocervical junction epidural arteriovenous fistula: Technical note 査読有り

Mansour, A., Endo, T., Inoue, T., Sato, K., Endo, H., Fujimura, M., Tominaga, T.

Journal of Neurosurgery: Spine　31　(2)　1-6　2019年4月

DOI： 10.3171/2019.1.SPINE18983 　

ISSN：1547-5646 1547-5654
Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels as a Biomarker of Acute Intracerebral Hemorrhage. 査読有り

Inoue T, Ishida T, Inoue T, Saito A, Ezura M, Uenohara H, Fujimura M, Sato K, Endo T, Omodaka S, Endo H, Niizuma K, Tominaga T

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association　28　(2)　490-494　2019年2月
出版者・発行元：
DOI： 10.1016/j.jstrokecerebrovasdis.2018.10.027 　

ISSN：1052-3057
Circumferential wall enhancement in evolving intracranial aneurysms on magnetic resonance vessel wall imaging 査読有り

Omodaka, S., Endo, H., Niizuma, K., Fujimura, M., Inoue, T., Endo, T., Sato, K., Sugiyama, S.-I., Tominaga, T.

Journal of Neurosurgery　131　(4)　1-7　2019年

DOI： 10.3171/2018.5.JNS18322 　

ISSN：1933-0693 0022-3085
Incidence and Risk Factors of the Watershed Shift Phenomenon after Superficial Temporal Artery-Middle Cerebral Artery Anastomosis for Adult Moyamoya Disease. 国際誌査読有り

Ryosuke Tashiro, Miki Fujimura, Masayuki Kameyama, Shunji Mugikura, Hidenori Endo, Yohei Takeuchi, Yasutake Tomata, Kuniyasu Niizuma, Teiji Tominaga

Cerebrovascular diseases (Basel, Switzerland)　47　(3-4)　178-187　2019年

DOI： 10.1159/000500802 　

ISSN：1015-9770

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OBJECTIVE: Superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis is the standard surgical management for adult moyamoya disease (MMD) patients, but local cerebral hyperperfusion (CHP) and cerebral ischemia are potential complications of this procedure. Recent hemodynamic analysis of the acute stage after revascularization surgery for MMD revealed a more complex and unique pathophysiological condition, the so-called "watershed shift (WS) phenomenon," which is defined as a paradoxical decrease in the cerebral blood flow (CBF) at the adjacent cortex near the site of local CHP. The objective of this study was to clarify the exact incidence, clinical presentation, and risk factors of the WS phenomenon after direct revascularization surgery for adult MMD. PATIENTS AND METHODS: Among 74 patients with MMD undergoing STA-MCA anastomosis for 78 affected hemispheres, 60 adult patients comprising 64 hemispheres underwent serial quantitative CBF analysis by N-isopropyl-p-[123I] iodoamphetamine single-photon emission computed tomography after revascularization surgery. The local CBF was quantitatively measured at the site of anastomosis and the adjacent cortex before surgery, as well as on 1 and 7 days after surgery. Then, we investigated the incidence, clinical presentation, and risk factors of the WS phenomenon. RESULTS: The WS phenomenon was evident in 7 patients (7/64 hemispheres; 10.9%) after STA-MCA anastomosis for adult MMD. None of the patients developed neurological deterioration due to the WS phenomenon, but 1 patient developed reversible ischemic change on diffusion-weighted imaging at the site of the WS phenomenon. Multivariate analysis revealed that a lower preoperative CBF value was significantly associated with the occurrence of the WS phenomenon (20.3 ± 7.70 mL/100 g/min in WS-positive group vs. 31.7 ± 8.81 mL/100 g/min in WS-negative group, p= 1.1 × 10-2). CONCLUSIONS: The incidence of the WS phenomenon was as high as 10.9% after STA-MCA anastomosis for adult MMD. The clinical outcome of the WS phenomenon is generally favorable, but there is a potential risk for perioperative cerebral infarction. Thus, we recommend routine CBF measurement in the acute stage after revascularization surgery for adult MMD to avoid surgical complications, such as local CHP and cerebral ischemia, caused by the WS phenomenon. Concomitant detection of the WS phenomenon with local CHP is clinically important because blood pressure reduction to counteract local CHP may have to be avoided in the presence of the WS phenomenon.
Identification of HLA-DRB1*04:10 allele as risk allele for Japanese moyamoya disease and its association with autoimmune thyroid disease: A case-control study. 国際誌査読有り

Ryosuke Tashiro, Kuniyasu Niizuma, Seik-Soon Khor, Katsushi Tokunaga, Miki Fujimura, Hiroyuki Sakata, Hidenori Endo, Hidetoshi Inoko, Koetsu Ogasawara, Teiji Tominaga

PloS one　14　(8)　e0220858　2019年

DOI： 10.1371/journal.pone.0220858 　

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BACKGROUND AND PURPOSE: Moyamoya disease (MMD) is a progressive cerebrovascular disease with unknown etiology. Growing evidence suggest its involvement of autoimmune and genetic mechanisms in the pathogenesis of MMD. This study aims to clarify the association between HLA allele and MMD. METHODS: Case-control study: the DNA of 136 MMD patients in Japan was extracted and the genotype of human leukocyte antigen (HLA) from this DNA was determined by super-high-resolution single-molecule sequence-based typing using next-generation sequencing. Next, the frequency of each HLA allele (HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQB1, and HLA-DPB1) was compared with those in the Japanese control database. In addition, haplotype estimation was performed using the expectation maximization algorithm. RESULTS: The frequencies of the HLA-DRB1*04:10 allele (4.77% vs. 1.47% in the control group; P = 1.7 × 10-3; odds ratio [OR] = 3.35) and of the HLA-DRB1*04:10-HLA-DQB1*04:02 haplotype (haplotype frequency 4.41% vs. 1.35% in the control group; P = 2.0 × 10-3; OR = 3.37) significantly increased. The frequency of thyroid diseases, such as Graves' disease and Hashimoto thyroiditis, increased in HLA-DRB1*04:10-positive MMD patients compared with that in HLA-DRB1*04:10-negative MMD patients. CONCLUSIONS: HLA-DRB1*04:10 is a risk allele and HLA-DRB1*04:10-HLA-DQB1*04:02 a risk haplotype for MMD. In addition, HLA-DRB1*04:10 is associated with thyroid disease in MMD patients.
Quantitative characterization of carotid plaque components using MR apparent diffusion coefficients and longitudinal relaxation rates at 3T: A comparison with histology. 国際誌査読有り

Ota H, Tamura H, Itabashi R, Yazawa Y, Nakamura Y, Hisamatsu K, Takamatsu M, Endo H, Niizuma K, Enomoto Y, Nagasaka T, Kajita K, Watanabe M, Yoshimura S, Yuan C

Journal of magnetic resonance imaging : JMRI　48　(6)　1657-1667　2018年12月

DOI： 10.1002/jmri.26216 　

ISSN：1053-1807
Revascularization of the anterior cerebral artery by Y-shaped superficial temporal artery interposition graft for the treatment of a de novo aneurysm arising at the site of A<inf>3</inf>-A<inf>3</inf> bypass: Technical case report 査読有り

Endo, H., Sugiyama, S.-I., Endo, T., Fujimura, M., Shimizu, H., Tominaga, T.

Journal of Neurosurgery　129　(5)　1120-1124　2018年11月

DOI： 10.3171/2017.6.JNS17931 　

ISSN：1933-0693 0022-3085
Early BBB breakdown and subacute inflammasome activation and pyroptosis as a result of cerebral venous thrombosis 査読有り

Rashad, S., Niizuma, K., Sato-Maeda, M., Fujimura, M., Mansour, A., Endo, H., Ikawa, S., Tominaga, T.

Brain Research　1699　54-68　2018年11月

DOI： 10.1016/j.brainres.2018.06.029 　

ISSN：1872-6240 0006-8993
Biphasic Development of Focal Cerebral Hyperperfusion After Revascularization Surgery for Adult Moyamoya Disease Associated With Autosomal Dominant Polycystic Kidney Disease. 国際誌査読有り

Tashiro R, Fujimura M, Endo H, Endo T, Niizuma K, Tominaga T

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association　27　(11)　3256-3260　2018年11月

DOI： 10.1016/j.jstrokecerebrovasdis.2018.07.024 　

ISSN：1052-3057
Growth of Thrombosed Cerebral Venous Varix Following Resection of Cerebral Arteriovenous Malformation: Case Report with Pathologic Consideration 査読有り

Haryu, S., Endo, H., Endo, T., Sato, K., Fujimura, M., Tominaga, T.

World Neurosurgery　119　274-277　2018年11月
出版者・発行元： Elsevier {BV}
DOI： 10.1016/j.wneu.2018.08.072 　

ISSN：1878-8769 1878-8750
A refined model of chronic cerebral hypoperfusion resulting in cognitive impairment and a low mortality rate in rats. 国際誌査読有り

Ahmed Mansour, Kuniyasu Niizuma, Sherif Rashad, Akira Sumiyoshi, Rie Ryoke, Hidenori Endo, Toshiki Endo, Kenichi Sato, Ryuta Kawashima, Teiji Tominaga

Journal of neurosurgery　131　(3)　892-902　2018年9月7日

DOI： 10.3171/2018.3.JNS172274 　

ISSN：0022-3085

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OBJECTIVE: The cognitive deficits of vascular dementia and the vasoocclusive state of moyamoya disease have often been mimicked with bilateral stenosis/occlusion of the common carotid artery (CCA) or internal carotid artery. However, the cerebral blood flow (CBF) declines abruptly in these models after ligation of the CCA, which differs from "chronic" cerebral hypoperfusion. While some modified but time-consuming techniques have used staged occlusion of both CCAs, others used microcoils for CCA stenosis, producing an adverse effect on the arterial endothelium. Thus, the authors developed a new chronic cerebral hypoperfusion (CCH) model with cognitive impairment and a low mortality rate in rats. METHODS: Male Sprague-Dawley rats were subjected to unilateral CCA occlusion and contralateral induction of CCA stenosis (modified CCA occlusion [mCCAO]) or a sham operation. Cortical regional CBF (rCBF) was measured using laser speckle flowmetry. Cognitive function was assessed using a Barnes circular maze (BCM). MRI studies were performed 4 weeks after the operation to evaluate cervical and intracranial arteries and parenchymal injury. Behavioral and histological studies were performed at 4 and 8 weeks after surgery. RESULTS: The mCCAO group revealed a gradual CBF reduction with a low mortality rate (2.3%). White matter degeneration was evident in the corpus callosum and corpus striatum. Although the cellular density declined in the hippocampus, MRI revealed no cerebral infarctions after mCCAO. Immunohistochemistry revealed upregulated inflammatory cells and angiogenesis in the hippocampus and cerebral cortex. Results of the BCM assessment indicated significant impairment in spatial learning and memory in the mCCAO group. Although some resolution of white matter injury was observed at 8 weeks, the animals still had cognitive impairment. CONCLUSIONS: The mCCAO is a straightforward method of producing a CCH model in rats. It is associated with a low mortality rate and could potentially be used to investigate vascular disease, moyamoya disease, and CCH. This model was verified for an extended time point of 8 weeks after surgery.
Surgical strategy for an adult patient with a catecholamine-producing ganglioneuroblastoma and a cerebral aneurysm: a case report. 国際誌査読有り

Kumata H, Nishimura R, Nakanishi C, Inoue C, Tezuka Y, Endo H, Miyagi S, Tominaga T, Unno M, Kamei T

Surgical case reports　4　(1)　119-119　2018年9月

DOI： 10.1186/s40792-018-0529-x 　
[Safety and Efficacy of Keishi-Bukuryo-Gan in Patients with Spontaneous Intracerebral Hemorrhage during the Acute Period:CT Image-Based Analysis of the Clearance of Hematoma]. 査読有り

Osawa SI, Endo H, Kawamura T, Tominaga T

No shinkei geka. Neurological surgery　46　(9)　763-770　2018年9月

DOI： 10.11477/mf.1436203810 　

ISSN：0301-2603
Paradoxical Association of Symptomatic Local Vasogenic Edema with Global Cerebral Hypoperfusion after Direct Revascularization Surgery for Adult Moyamoya Disease. 国際誌査読有り

Tashiro R, Fujimura M, Mugikura S, Niizuma K, Endo H, Endo T, Tominaga T

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association　27　(8)　e172-e176　2018年8月

DOI： 10.1016/j.jstrokecerebrovasdis.2018.03.002 　

ISSN：1052-3057
Circumferential wall enhancement on magnetic resonance imaging is useful to identify rupture site in patients with multiple cerebral aneurysms 査読有り

Omodaka, S., Endo, H., Niizuma, K., Fujimura, M., Endo, T., Sato, K., Sugiyama, S.-I., Inoue, T., Tominaga, T.

Neurosurgery　82　(5)　638-644　2018年5月

DOI： 10.1093/neuros/nyx267 　

ISSN：1524-4040 0148-396X
Endovascular Treatments in Combination with Extracranial-Intracranial Bypass for Complex Intracranial Aneurysms 査読有り

Kenichi Sato, Hidenori Endo, Miki Fujimura, Toshiki Endo, Yasushi Matsumoto, Hiroaki Shimizu, Teiji Tominaga

World Neurosurgery　113　e747-e760　2018年5月1日
出版者・発行元： Elsevier Inc.
DOI： 10.1016/j.wneu.2018.02.143 　

ISSN：1878-8769 1878-8750
Impact of bifurcation angle and inflow coefficient on the rupture risk of bifurcation type basilar artery tip aneurysms 査読有り

Sherif Rashad, Shin-Ichiro Sugiyama, Kuniyasu Niizuma, Kenichi Sato, Hidenori Endo, Shunsuke Omodaka, Yasushi Matsumoto, Miki Fujimura, Teiji Tominaga

Journal of Neurosurgery　128　(3)　723-730　2018年3月1日
出版者・発行元： American Association of Neurological Surgeons
DOI： 10.3171/2016.10.JNS161695 　

ISSN：1933-0693 0022-3085
Clinical Characteristics of Lumbosacral Spinal Dural Arteriovenous Fistula (DAVF)–Comparison with Thoracic DAVF 査読有り

Toshiki Endo, Takumi Kajitani, Tomoo Inoue, Kenichi Sato, Kuniyasu Niizuma, Hidenori Endo, Yasushi Matsumoto, Teiji Tominaga

World Neurosurgery　110　e383-e388　2018年2月1日
出版者・発行元： Elsevier Inc.
DOI： 10.1016/j.wneu.2017.11.002 　

ISSN：1878-8769 1878-8750
Expression of CD133 as a Putative Prognostic Biomarker to Predict Intracranial Dissemination of Primary Spinal Cord Astrocytoma 査読有り

Tomoo Inoue, Toshiki Endo, Taigen Nakamura, Ichiyo Shibahara, Hidenori Endo, Teiji Tominaga

World Neurosurgery　110　e715-e726　2018年2月1日
出版者・発行元： Elsevier Inc.
DOI： 10.1016/j.wneu.2017.11.089 　

ISSN：1878-8769 1878-8750
Current indications and problems of CEA and CAS

Endo, H., Fujimura, M., Matsumoto, Y., Endo, T., Sato, K., Niizuma, K., Inoue, T., Tominaga, T.

Japanese Journal of Neurosurgery　27　(7)　2018年

DOI： 10.7887/jcns.27.514 　

ISSN：0917-950X
Embolization of ruptured arteriovenous malformations in the cerebellopontine angle cistern 査読有り

Hidenori Endo, Shin-ichiro Osawa, Yasushi Matsumoto, Toshiki Endo, Kenichi Sato, Kuniyasu Niizuma, Miki Fujimura, Teiji Tominaga

Neurosurgical Review　41　(1)　173-182　2018年1月1日
出版者・発行元： Springer Verlag
DOI： 10.1007/s10143-017-0832-1 　

ISSN：1437-2320 0344-5607
Patient with Recurrent Anterior Cerebral Artery Dissecting Aneurysm After Stent-Assisted Coil Embolization Successfully Treated with A3-A3 Anastomosis 査読有り

Yoshiharu Takahashi, Hidenori Endo, Toshiki Endo, Miki Fujimura, Kuniyasu Niizuma, Teiji Tominaga

World Neurosurgery　109　77-81　2018年1月1日
出版者・発行元： Elsevier Inc.
DOI： 10.1016/j.wneu.2017.09.128 　

ISSN：1878-8769 1878-8750
Successful presurgical endovascular management of venous sinus thrombosis associated with high-grade cerebral arteriovenous malformation: A case report 査読有り

Yoshinari Osada, Hidenori Endo, Kenichi Sato, Yasushi Matsumoto, Toshiki Endo, Miki Fujimura, Teiji Tominaga

Interventional Neuroradiology　23　(6)　656-660　2017年12月1日
出版者・発行元： SAGE Publications Inc.
DOI： 10.1177/1591019917728255 　

ISSN：1591-0199
Ruptured Vertebral Artery Dissecting Aneurysm Concurrent with Spontaneous Cervical Internal Carotid Artery Dissection: A Report of Three Cases and Literature Review 査読有り

Yosuke Akamatsu, Kenichi Sato, Hidenori Endo, Yasushi Matsumoto, Teiji Tominaga

WORLD NEUROSURGERY　107　1048.e1-1048.e6　2017年11月

DOI： 10.1016/j.wneu.2017.08.016 　

ISSN：1878-8750

eISSN：1878-8769
Intra-operative hemorrhage due to hyperperfusion during direct revascularization surgery in an adult patient with moyamoya disease: a case report 査読有り

Hiroki Uchida, Hidenori Endo, Miki Fujimura, Toshiki Endo, Kuniyasu Niizuma, Teiji Tominaga

NEUROSURGICAL REVIEW　40　(4)　679-684　2017年10月

DOI： 10.1007/s10143-017-0868-2 　

ISSN：0344-5607

eISSN：1437-2320
Temporal and Spatial Changes in Cerebral Blood Flow during Management for Preventing Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage: Serial Semiquantitative Analysis 査読有り

Kenichi Sato, Hiroaki Shimizu, Takashi Inoue, Miki Fujimura, Hidenori Endo, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　26　(9)　2027-2037　2017年9月

DOI： 10.1016/j.jstrokecerebrovasdis.2017.06.006 　

ISSN：1052-3057

eISSN：1532-8511
Single-Session Hematoma Removal and Transcranial Coil Embolization for a Cavernous Sinus Dural Arteriovenous Fistula: A Technical Case Report 査読有り

Yosuke Akamatsu, Kenichi Sato, Hidenori Endo, Yasushi Matsumoto, Teiji Tominaga

WORLD NEUROSURGERY　104　1046.e7-1046.e12　2017年8月

DOI： 10.1016/j.wneu.2017.04.009 　

ISSN：1878-8750

eISSN：1878-8769
Application of actuator-driven pulsed water jet in aneurysmal subarachnoid hemorrhage surgery: its effectiveness for dissection around ruptured aneurysmal walls and subarachnoid clot removal 査読有り

Hidenori Endo, Toshiki Endo, Atsuhiro Nakagawa, Miki Fujimura, Teiji Tominaga

NEUROSURGICAL REVIEW　40　(3)　485-493　2017年7月

DOI： 10.1007/s10143-016-0809-5 　

ISSN：0344-5607

eISSN：1437-2320
Navigation-guided clipping of a de novo aneurysm associated with superficial temporal artery-middle cerebral artery bypass combined with indirect pial synangiosis in a patient with moyamoya disease 査読有り

Daiki Aburakawa, Miki Fujimura, Kuniyasu Niizuma, Hiroyuki Sakata, Hidenori Endo, Teiji Tominaga

NEUROSURGICAL REVIEW　40　(3)　517-521　2017年7月

DOI： 10.1007/s10143-017-0866-4 　

ISSN：0344-5607

eISSN：1437-2320
A hemorrhagic complication after Onyx embolization of a tentorial dural arteriovenous fistula: A caution about subdural extension with pial arterial supply 査読有り

Kenichi Sato, Yasushi Matsumoto, Hidenori Endo, Teiji Tominaga

INTERVENTIONAL NEURORADIOLOGY　23　(3)　307-312　2017年6月

DOI： 10.1177/1591019917694839 　

ISSN：1591-0199

eISSN：2385-2011
Use of Indocyanine Green Fluorescence Endoscopy to Treat Concurrent Perimedullary and Dural Arteriovenous Fistulas in the Cervical Spine 査読有り

Akira Ito, Toshiki Endo, Tomoo Inoue, Hidenori Endo, Kenichi Sato, Teiji Tominaga

WORLD NEUROSURGERY　101　814.e1-814.e6　2017年5月

DOI： 10.1016/j.wneu.2017.03.032 　

ISSN：1878-8750

eISSN：1878-8769
Embolization of the choroidal artery in the treatment of cerebral arteriovenous malformations 査読有り

Alaa Elkordy, Hidenori Endo, Kenichi Sato, Yasushi Matsumoto, Ryushi Kondo, Kuniyasu Niizuma, Toshiki Endo, Miki Fujimura, Teiji Tominaga

JOURNAL OF NEUROSURGERY　126　(4)　1114-1122　2017年4月

DOI： 10.3171/2016.2.JNS152370 　

ISSN：0022-3085

eISSN：1933-0693
Stereotactic radiosurgery as a feasible treatment for intramedullary spinal arteriovenous malformations: a single-center observation 査読有り

Sherif Rashad, Toshiki Endo, Yoshihiro Ogawa, Kenichi Sato, Hidenori Endo, Yasushi Matsumoto, Akira Takahashi, Teiji Tominaga

NEUROSURGICAL REVIEW　40　(2)　259-266　2017年4月

DOI： 10.1007/s10143-016-0758-z 　

ISSN：0344-5607

eISSN：1437-2320
New Application of Actuator-Driven Pulsed Water Jet for Spinal Cord Dissection: An Experimental Study in Pigs 査読有り

Toshiki Endo, Jia Wenting, Atsuhiro Nakagawa, Hidenori Endo, Yuto Sagae, Masaki Iwasaki, Teiji Tominaga

JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY　78　(2)　137-143　2017年3月

DOI： 10.1055/s-0036-1584919 　

ISSN：2193-6315

eISSN：2193-6323
Erratum to “Choices of Stent and Cerebral Protection in the Ongoing ACST-2 Trial: A Descriptive Study” (European Journal of Vascular and Endovascular Surgery (2017) 53(5) (617–625) (S1078588417300424) (10.1016/j.ejvs.2016.12.034))

de Waard, D.D., Halliday, A., de Borst, G.J., Bulbulia, R., Huibers, A., Casana, R., Bonati, L.H., Tolva, V., Fraedrich, G., Rantner, B., Gizewski, E., Gruber, I., Hendriks, J., Cras, P., Lauwers, P., van Scheil, P., Vermassen, F., Van Herzeele, I., Geenens, M., Hemelsoet, D., Lerut, P., Lambrecht, B., Saad, G., Peeters, A., Bosiers, M., da Silva, E., de Luccia, N., Sitrangulo, J.C., Estenssoro, A.E.V., Presti, C., Casella, I., Monteiro, J.A.T., Campos, W., Puech-Leao, P., Petrov, V., Bachvarov, C., Hill, M., Mitha, A., Wong, J., Liu, C.-W., Bao, L., Yu, C., Cvjetko, I., Vidjak, V., Fiedler, J., Ostry, S., Sterba, L., Kostal, P., Staffa, R., Vlachovsky, R., Privara, M., Kriz, Z., Vojtisek, B., Krupa, P., Reif, M., Benes, V., Buchvald, P., Endrych, L., Prochazka, V., Kuliha, M., Otahal, D., Hrbac, T., Netuka, D., Mohapl, M., Kramier, F., Eldessoki, M., Heshmat, H., Abd-Allah, F., Palmiste, V., Margus, S., Toomsoo, T., Becquemin, J.-P., Bergeron, P., Abdulamit, T., Cardon, J.-M., Debus, S., Thomalla, G., Fiehler, J., Gerloss, C., Grzyska, U., Storck, M., LaMacchia, E., Eckstein, H.H., S{\"o}llner, H., Berger, H., Kallmayer, M., Popert, H., Zimmermann, A., Guenther, A., Klingner, C., Mayer, T., Schubert, J., Zanow, J., Scheinert, D., Banning-Eichenseer, U., Bausback, Y., Branzan, D., Bra{\"u}nilch, S., Lenzer, J., Schidt, A., Staab, H., Ulirch, M., Barlinn, J., Haase, K., Abramyuk, A., Bodechtel, U., Gerber, J., Reeps, C., Pfeiffer, T., Torello, G., C{\"o}ster, A., Giannoukas, A., Spanos, K., Matsagkas, M., Koutias, S., Vasdekis, S., Kakisis, J., Moulakakis, K., Lazaris, A., Liapas, C., Brountzos, E., Lazarides, M., Ioannou, N., Polydorou, A., Fulop, B., Fako, E., Voros, E., Bodosi, M., Nemeth, T., Barzo, P., Pazdernyik, S., Entz, L., Szeberin, Z., Dosa, E., Nemes, B., Jaranyi, Z., Pazdernyia, S., Madhaban, P., Hoffman, A., Nikolsky, E., Beyar, R., Silingardi, R., Lauricella, A., Coppi, G., Nicoloci, E., Tusini, N., Strozzi, F., Vecchiati, E., Ferri, M., Ferrero, E., Psacharopulo, D., Gaggiano, A., Viazzo, A., Farchioni, L., Parlani, G., Caso, V., De Rangoy, P., Verzini, F., Castelli, P., DeLodovici, M.L., Carrafiello, G., Ierardi, A.M., Piffaretti, G., Nano, G., Occhiuto, M.T., Malacrida, G., Tealdi, D., Steghter, S., Stella, A., Pini, R., Faggioli, G., Sacca, S., Negri, M.D., Palombo, M., Perfumo, M.C., Fadda, G.F., Kasemi, H., Cernetti, C., Tonello, D., Vison{\`a}, A., Mangialardi, N., Ronchey, S., Altavista, M.C., Michelagnoli, S., Chisci, E., Speziale, F., Capoccia, L., Veroux, P., Giaquinta, A., Patti, F., Pulli, R., Boggia, P., Angiletta, D., Amatucci, G., Spinetti, F., Mascoli, F., Tsolaki, E., Civilini, E., Reimers, B., Setacci, C., Pogany, G., Odero, A., Accrocca, F., Bajardi, G., Takashi, I., Masayuki, E., Hidenori, E., Aidashova, B., Kospanov, N., Bakke, S., Skjell, , M., Czlonkowska, A., Kobayashi, A., Proczka, R., Dowzenko, A., Czepel, W., Polanski, J., Bialek, P., Ozkinis, G., Stanisic, M., Iwanowski, W., Andziak, P., Gon?alves, F.B., Starodubtsev, V., Ignatenko, P., Karpenko, A., Radak, D., Aleksic, N., Sagic, D., Davidovic, L., Koncar, I., Tomic, I., Colic, M., Bartkoy, D., Rusnak, F., Gaspirini, M., Praczek, P., Milosevic, Z., Flis, V., Bergauer, A., Kobilica, N., Miksic, K., Matela, J., Blanco, E., Guerra, M., Riambau, V., Gillgren, P., Skioldebr, , C., Nymen, N., Berg, B., Delle, M., Formgren, J., Kally, T.B., Qvarfordt, P., Plate, G., P{\"a}rson, H., Lindgren, H., Bjorses, K., Gotts{\"a}ter, A., Warvsten, M., Kristmundsson, T., Forssell, C., Malina, M., Holst, J., Kuhme, T., Sonesson, B., Lindblad, B., Kolbel, T., Acosta, S., Bonati, L., Traenka, C., Mueller, M., Lattman, T., Wasner, M., Mujagic, E., Von Hessling, A., Isaak, A., Stierli, P., Eugster, T., Mariani, L., Stippich, C., Wolff, T., Kahles, T., Toorop, R., Moll, F., Lo, R., Meershoek, A., Jahrome, A.K., Vos, A.W.F., Schuiling, W., Keunen, R., Reijnen, M., Macsweeney, S., McConachie, N., Southam, A., Stansby, G., Lees, T., Lambert, D., Clarke, M., Wyatt, M., Kappadath, S., Wales, L., Jackson, R., Raudonaitis, A., MacDonald, S., Dunlop, P., Brown, A., Vetrivel, S., Bajoriene, M., Gopi, R., McCollum, C., Wolowczyk, L., Ghosh, J., Seriki, D., Ashleigh, R., Butterfield, J., Welch, M., Smyth, J.V., Briley, D., Schulz, U., Perkins, J., H, s, L., Kuker, W., Darby, C., H, a, A., Sekaran, L., Poskitt, K., Morrison, J., Guyler, P., Grunwald, I., Brown, J., Jakeways, M., Tysoe, S., Hargroves, D., Gunathilagan, G., Insall, R., Senaratne, J., Beard, J., Clevel, , T., Nawaz, S., Lonsdale, R., Turner, D., Gaines, P., Nair, R., Chetter, I., Robinson, G., Akomolafe, B., Hatfield, J., Saastamoinen, K., Crinnion, J., Egun, A.A., Thomas, J., Drinkwater, S., D{'}Souza, S., Thomson, G., Gregory, B., Babu, S., Joseph, T., Gibbs, R., Tebit, G., Mehrzad, A., Enevoldson, P., Mendalow, D., Parry, A., Tervitt, G., Clifton, A., Nazzel, M., Peto, R., Pan, H., Potter, J., Bullbulia, R., Ashley, S., Flather, M., Mansfield, A., Simpson, D., Thomas, D., Gray, W., Farrell, B., Davies, C., Rahimi, K., Gough, M., Cao, P., Rothwell, P., Belli, A., Mafham, M., Herrington, W., S, ercock, P., Gray, R., Shearman, C., Molyneux, A., Gray, A., Clarke, A., Sneade, M., Tully, L., Brudlo, W., Lay, M., Munday, A., Berry, C., Tochlin, S., Mihaylova, B., Cox, J., Kurien, R., Chester, J.

European Journal of Vascular and Endovascular Surgery　54　(3)　407-407　2017年

DOI： 10.1016/j.ejvs.2017.06.013 　

ISSN：1532-2165 1078-5884
Efficacy of revascularization surgery for the adult patients with hemorrhagic-onset moyamoya disease

Fujimura, M., Endo, H., Niizuma, K., Tominaga, T.

Japanese Journal of Neurosurgery　26　(2)　2017年

DOI： 10.7887/jcns.26.112 　

ISSN：0917-950X
De Novo Development of Moyamoya Disease in an Adult Female with a Genetic Variant of the RNF-213 Gene: Case Report 査読有り

Ryosuke Tashiro, Miki Fujimura, Kuniyasu Niizuma, Hidenori Endo, Hiroyuki Sakata, Mika Sato-Maeda, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　26　(1)　E8-E11　2017年1月

DOI： 10.1016/j.jstrokecerebrovasdis.2016.09.035 　

ISSN：1052-3057

eISSN：1532-8511
Traumatic Spinal Perimedullary Arteriovenous Fistula Induced by a Cervical Glass Stab Injury 査読有り

Shogo Ogita, Toshiki Endo, Tomoo Inoue, Kenichi Sato, Hidenori Endo, Teiji Tominaga

WORLD NEUROSURGERY　96　610.e9-610.e13　2016年12月

DOI： 10.1016/j.wneu.2016.09.024 　

ISSN：1878-8750

eISSN：1878-8769
Daughter Sac Formation Related to Blood Inflow Jet in an Intracranial Aneurysm 査読有り

Sin-ichiro Sugiyama, Hidenori Endo, Shunsuke Omodaka, Toshiki Endo, Kuniyasu Niizuma, Sherif Rashad, Toshio Nakayama, Kenichi Funamoto, Makoto Ohta, Teiji Tominaga

WORLD NEUROSURGERY　96　396-402　2016年12月

DOI： 10.1016/j.wneu.2016.09.040 　

ISSN：1878-8750

eISSN：1878-8769
Long-term follow-up of pediatric moyamoya disease treated by combined direct–indirect revascularization surgery: single institute experience with surgical and perioperative management 査読有り

Sherif Rashad, Miki Fujimura, Kuniyasu Niizuma, Hidenori Endo, Teiji Tominaga

Neurosurgical Review　39　(4)　615-623　2016年10月1日
出版者・発行元： Springer Verlag
DOI： 10.1007/s10143-016-0734-7 　

ISSN：1437-2320 0344-5607
Development of Abnormal Hemispheric Vascular Networks Mimicking Cerebral Proliferative Angiopathy in a Child Originally Diagnosed with Deep-Seated Arteriovenous Fistula 査読有り

Hiroyuki Sakata, Miki Fujimura, Kenichi Sato, Kuniyasu Niizuma, Hidenori Endo, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　25　(10)　E200-E204　2016年10月

DOI： 10.1016/j.jstrokecerebrovasdis.2016.07.042 　

ISSN：1052-3057

eISSN：1532-8511
Blood Flow Into Basilar Tip Aneurysms: A Predictor for Recanalization After Coil Embolization 査読有り

Shin-ichiro Sugiyama, Kuniyasu Niizuma, Kenichi Sato, Sherif Rashad, Misaki Kohama, Hidenori Endo, Toshiki Endo, Yasushi Matsumoto, Makoto Ohta, Teiji Tominaga

STROKE　47　(10)　2541-2547　2016年10月

DOI： 10.1161/STROKEAHA.116.013555 　

ISSN：0039-2499

eISSN：1524-4628
A study of prognostic factors in 45 cases of atypical meningioma 査読有り

Toshiki Endo, Ayumi Narisawa, Hosam Shata Mohamed Ali, Kensuke Murakami, Takashi Watanabe, Mika Watanabe, Hidefumi Jokura, Hidenori Endo, Miki Fujimura, Yukihiko Sonoda, Teiji Tominaga

ACTA NEUROCHIRURGICA　158　(9)　1661-1667　2016年9月

DOI： 10.1007/s00701-016-2900-7 　

ISSN：0001-6268

eISSN：0942-0940
Quantitative Assessment of Circumferential Enhancement along the Wall of Cerebral Aneurysms Using MR Imaging 査読有り

S. Omodaka, H. Endo, K. Niizuma, M. Fujimura, T. Inoue, K. Sato, S. -I. Sugiyama, T. Tominaga

AMERICAN JOURNAL OF NEURORADIOLOGY　37　(7)　1262-1266　2016年7月

DOI： 10.3174/ajnr.A4722 　

ISSN：0195-6108

eISSN：1936-959X
Brain Stem Infarction Due to Basilar Artery Dissection in a Patient with Moyamoya Disease Four Years after Successful Bilateral Revascularization Surgeries 査読有り

Takatsugu Abe, Miki Fujimura, Shunji Mugikura, Hidenori Endo, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　25　(6)　E79-E82　2016年6月

DOI： 10.1016/j.jstrokecerebrovasdis.2016.03.024 　

ISSN：1052-3057

eISSN：1532-8511
Intraspinal dissemination of intracranial hemangiopericytoma: Case report and literature review 査読有り

Hosam Shata Mohanmed Ali, Toshiki Endo, Hidenori Endo, Kensuke Murakami, Teiji Tominaga

Surgical Neurology International　7　(41)　S1016-S1020　2016年
出版者・発行元： Medknow Publications
DOI： 10.4103/2152-7806.195585 　

ISSN：2152-7806
A case of ruptured infectious anterior cerebral artery aneurysm treated by interposition graft bypass using the superficial temporal artery. 査読有り

Abe T, Endo H, Shimizu H, Fujimura M, Endo T, Sakata H, Watanabe M, Tominaga T

Surgical neurology international　7　5　2016年

DOI： 10.4103/2152-7806.173319 　

ISSN：2229-5097
Surgical and Endovascular Treatment for Spinal Arteriovenous Malformations 査読有り

Toshiki Endo, Hidenori Endo, Kenichi Sato, Yasushi Matsumoto, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　56　(8)　457-464　2016年

DOI： 10.2176/nmc.ra.2015-0327 　

ISSN：0470-8105

eISSN：1349-8029
Difference in Transcranial Doppler Velocity and Patient Age between Proximal and Distal Middle Cerebral Artery Vasospasms after Aneurysmal Subarachnoid Hemorrhage. 国際誌査読有り

Misaki Kohama, Shinichiro Sugiyama, Kenichi Sato, Hidenori Endo, Kuniyasu Niizuma, Toshiki Endo, Makoto Ohta, Yasushi Matsumoto, Miki Fujimura, Teiji Tominaga

Cerebrovascular diseases extra　6　(2)　32-9　2016年

DOI： 10.1159/000447330 　

詳細を見る詳細を閉じる

BACKGROUND: Transcranial Doppler (TCD) is used to monitor cerebral vasospasm after subarachnoid hemorrhage (SAH), but its diagnostic ability is reported to be limited. Therefore, the purpose of this study was to investigate the relationship between the diagnosability of TCD and the localization of the vasospasm. METHODS: This retrospective study included 20 patients who presented with symptomatic vasospasm after SAH. All 20 patients underwent daily TCD examinations and cerebral angiography after the onset of delayed cerebral ischemia. We defined positive findings on TCD as a maximum flow velocity >200 cm/s or as a mean flow velocity >120 cm/s at the horizontal part of the middle cerebral artery (MCA). We also examined the site of vasospasm on cerebral angiography. RESULTS: Fourteen patients had true-positive findings on TCD examination, and cerebral angiography showed diffuse vasospasm involving the horizontal segment of the MCA. However, 6 patients had false-negative findings on TCD examination, and cerebral angiography showed vasospasm localized at the distal part of the MCA (the insular and/or cortical segments). The patients with proximal vasospasm were significantly younger than those with distal vasospasm. Blood flow velocity at initial TCD and the increase in velocity at the onset of vasospasm were lower and smaller, respectively, in the distal vasospasm group. CONCLUSIONS: In patients with cerebral vasospasm localized at the distal part of the MCA, flow velocity at the horizontal segment of the MCA did not increase to the level we defined as positive. To avoid such false negatives, a slight increase in velocity on TCD should be considered as positive in distal vasospasm cases, especially in older patients.
Computational Hemodynamic Analysis for the Diagnosis of Atherosclerotic Changes in Intracranial Aneurysms: A Proof-of-Concept Study Using 3 Cases Harboring Atherosclerotic and Nonatherosclerotic Aneurysms Simultaneously 査読有り

Shin-ichiro Sugiyama, Hidenori Endo, Kuniyasu Niizuma, Toshiki Endo, Kenichi Funamoto, Makoto Ohta, Teiji Tominaga

COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE　2016　2386031　2016年

DOI： 10.1155/2016/2386031 　

ISSN：1748-670X

eISSN：1748-6718
Intraspinal dissemination of intracranial hemangiopericytoma: Case report and literature review. 査読有り

Ali HS, Endo T, Endo H, Murakami K, Tominaga T

Surgical neurology international　7　(Suppl 40)　S1016-S1020　2016年

DOI： 10.4103/2152-7806.195585 　

ISSN：2229-5097
Risk factors for meningitis after craniotomy in patients with subarachnoid hemorrhage due to anterior circulation aneurysms rupture 査読有り

Takashi Inoue, Hiroaki Shimizu, Miki Fujimura, Kenichi Sato, Hidenori Endo, Kuniyasu Niizuma, Hiroyuki Sakata, Teiji Tominaga

CLINICAL NEUROLOGY AND NEUROSURGERY　139　302-306　2015年12月

DOI： 10.1016/j.clineuro.2015.10.029 　

ISSN：0303-8467

eISSN：1872-6968
Cerebral Blood Flow after Acute Bypass with Parent Artery Trapping in Patients with Ruptured Supraclinoid Internal Carotid Artery Aneurysms 査読有り

Hidenori Endo, Miki Fujimura, Hiroaki Shimizu, Takashi Inoue, Kenichi Sato, Kuniyasu Niizuma, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　24　(10)　2358-2368　2015年10月

DOI： 10.1016/j.jstrokecerebrovasdis.2015.06.028 　

ISSN：1052-3057

eISSN：1532-8511
High-grade Cerebral Arteriovenous Malformation Treated with Targeted Embolization of a Ruptured Site: Wall Enhancement of an Intranidal Aneurysm as a Sign of Ruptured Site 査読有り

Shunsuke Omodaka, Hidenori Endo, Miki Fujimura, Kuniyasu Niizuma, Kenichi Sato, Yasushi Matsumoto, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　55　(10)　813-817　2015年9月

DOI： 10.2176/nmc.cr.2015-0052 　

ISSN：0470-8105

eISSN：1349-8029
Outflow Occlusion with Occipital Artery-Posterior Inferior Cerebellar Artery Bypass for Growing Vertebral Artery Fusiform Aneurysm with Ischemic Onset: A Case Report 査読有り

Ryuzaburo Kochi, Hidenori Endo, Miki Fujimura, Kenichi Sato, Shin-ichiro Sugiyama, Shin-ichiro Osawa, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　24　(8)　E223-E226　2015年8月

DOI： 10.1016/j.jstrokecerebrovasdis.2015.04.020 　

ISSN：1052-3057

eISSN：1532-8511
Therapeutic Clip Occlusion of the Anterior Choroidal Artery Involved with Partially Thrombosed Fusiform Aneurysm: A Case Report 査読有り

Sherif Rashad, Hidenori Endo, Ahmed Elsayed Sultan, Hiroaki Shimizu, Miki Fujimura, Kenichi Sato, Yasushi Matsumoto, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　24　(8)　E227-E230　2015年8月

DOI： 10.1016/j.jstrokecerebrovasdis.2015.04.024 　

ISSN：1052-3057

eISSN：1532-8511
Ruptured Cerebral Microaneurysm Diagnosed by 3-Dimensional Fast Spin-Echo T1 Imaging with Variable Flip Angles 査読有り

Hidenori Endo, Kuniyasu Niizuma, Miki Fujimura, Kenichi Sato, Takashi Inoue, Shin-ichiro Osawa, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　24　(8)　E231-E235　2015年8月

DOI： 10.1016/j.jstrokecerebrovasdis.2015.04.031 　

ISSN：1052-3057

eISSN：1532-8511
A case of akin moyamoya disease associated with type-I diabetes mellitus managed by extracranial-intracranial bypass 査読有り

Yosuke Akamatsu, Miki Fujimura, Hiroyuki Sakata, Hidenori Endo, Ryo Itabashi, Teiji Tominaga

Neurological Surgery　43　(3)　227-233　2015年3月1日
出版者・発行元： Igaku-Shoin Ltd
DOI： 10.11477/mf.1436202991 　

ISSN：1882-1251 0301-2603
Quantitative analysis of early postoperative cerebral blood flow contributes to the prediction and diagnosis of cerebral hyperperfusion syndrome after revascularization surgery for moyamoya disease 査読有り

Miki Fujimura, Kuniyasu Niizuma, Hidenori Endo, Kenichi Sato, Takashi Inoue, Hiroaki Shimizu, Teiji Tominaga

NEUROLOGICAL RESEARCH　37　(2)　131-138　2015年2月

DOI： 10.1179/1743132814Y.0000000432 　

ISSN：0161-6412

eISSN：1743-1328
Combined open and endovascular surgery for complex cerebral aneurysms 査読有り

Hiroaki Shimizu, Yasushi Matsumoto, Hidenori Endo, Takashi Inoue, Miki Fujimura, Teiji Tominaga

Japanese Journal of Neurosurgery　24　(3)　165-172　2015年
出版者・発行元： Japanese Congress of Neurological Surgeons
DOI： 10.7887/jcns.24.165 　

ISSN：0917-950X
Porosity dependency of an optimized stent design for an intracranial aneurysm 査読有り

Anzai, H., Yoshida, Y., Sugiyama, S., Endo, H., Matsumoto, Y., Ohta, M.

Technology and Health Care　23　(5)　547-556　2015年

DOI： 10.3233/THC-151007 　
Usefulness of Laser Speckle Flowgraphy for the Assessment of Ocular Blood Flow in Extracranial-Intracranial Bypass 査読有り

Shunsuke Omodaka, Hidenori Endo, Hiroshi Doi, Hiroaki Shimizu, Miki Fujimura, Naoko Aizawa, Toru Nakazawa, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　23　(10)　E445-E448　2014年11月

DOI： 10.1016/j.jstrokecerebrovasdis.2014.06.021 　

ISSN：1052-3057

eISSN：1532-8511
Minocycline Prevents Focal Neurological Deterioration Due to Cerebral Hyperperfusion After Extracranial-Intracranial Bypass for Moyamoya Disease 査読有り

Miki Fujimura, Kuniyasu Niizuma, Takashi Inoue, Kenichi Sato, Hidenori Endo, Hiroaki Shimizu, Teiji Tominaga

NEUROSURGERY　74　(2)　163-170　2014年2月

DOI： 10.1227/NEU.0000000000000238 　

ISSN：0148-396X

eISSN：1524-4040
Surgical treatment for internal carotid artery aneurysms requiring strategic selective clipping or parent artery occlusion/flow alteration

Shimizu, H., Endo, H., Inoue, T., Fujimura, M., Matsumoto, Y., Tominaga, T.

Japanese Journal of Neurosurgery　23　(9)　2014年

DOI： 10.7887/jcns.23.721 　

ISSN：0917-950X
Angiographic circulation time and cerebral blood flow during balloon test occlusion of the internal carotid artery 査読有り

Kenichi Sato, Hiroaki Shimizu, Takashi Inoue, Miki Fujimura, Yasushi Matsumoto, Ryushi Kondo, Hidenori Endo, Yukihiko Sonoda, Teiji Tominaga

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　34　(1)　136-143　2014年1月

DOI： 10.1038/jcbfm.2013.176 　

ISSN：0271-678X

eISSN：1559-7016
Endovascular Embolization of Cerebral Arteriovenous Malformations: Results of the Japanese Registry of Neuroendovascular Therapy (JR-NET) 1 and 2 査読有り

Ryushi Kondo, Yasushi Matsumoto, Hidenori Endo, Shigeru Miyachi, Masayuki Ezura, Nobuyuki Sakai

NEUROLOGIA MEDICO-CHIRURGICA　54　(1)　54-62　2014年1月

DOI： 10.2176/nmc.oa2013-0183 　

ISSN：0470-8105

eISSN：1349-8029
Endovascular Embolization of Cerebral Arteriovenous Malformations: Results of the Japanese Registry of Neuroendovascular Therapy (JR-NET) 1 and 2 査読有り

Ryushi Kondo, Yasushi Matsumoto, Hidenori Endo, Shigeru Miyachi, Masayuki Ezura, Nobuyuki Sakai

NEUROLOGIA MEDICO-CHIRURGICA　54　(1)　54-62　2014年1月

DOI： 10.2176/nmc.oa2013-0183 　

ISSN：0470-8105

eISSN：1349-8029
第三脳室開窓術後にSIADHによる低ナトリウム血症を呈した1例査読有り

重枝諒太, 遠藤英徳, 藤村幹, 小川欣一, 清水宏明, 冨永悌二

Neurological Surgery　42　(4)　335-339　2014年
出版者・発行元： (株)医学書院
ISSN：1882-1251 0301-2603

eISSN：1882-1251
Signal changes on T2*-weighted magnetic resonance imaging from the acute to chronic phases in patients with subarachnoid hemorrhage 査読有り

Takashi Inoue, Shihomi Takada, Hiroaki Shimizu, Kuniyasu Niizuma, Miki Fujimura, Kenichi Sato, Hidenori Endo, Teiji Tominaga

Cerebrovascular Diseases　36　(5-6)　421-429　2013年12月

DOI： 10.1159/000355897 　

ISSN：1015-9770 1421-9786

eISSN：1421-9786
Efficacy of fusion image for the preoperative assessment of anatomical variation of the anterior choroidal artery 査読有り

Yasuko Aoki, Hidenori Endo, Kuniyasu Nnzuma, Takashi Inoue, Hiroaki Shimizu, Teiji Tominaga

Neurological Surgery　41　(12)　1075-1080　2013年12月

ISSN：0301-2603 1882-1251

eISSN：1882-1251
Relative Residence Time Prolongation in Intracranial Aneurysms: A Possible Association With Atherosclerosis 査読有り

Shin-ichiro Sugiyama, Kuniyasu Niizuma, Toshio Nakayama, Hiroaki Shimizu, Hidenori Endo, Takashi Inoue, Miki Fujimura, Makoto Ohta, Akira Takahashi, Teiji Tominaga

NEUROSURGERY　73　(5)　767-776　2013年11月

DOI： 10.1227/NEU.0000000000000096 　

ISSN：0148-396X

eISSN：1524-4040
Medullary infarction as a poor prognostic factor after internal coil trapping of a ruptured vertebral artery dissection Clinical article 査読有り

Hidenori Endo, Yasushi Matsumoto, Ryushi Kondo, Kenichi Sato, Miki Fujimura, Takashi Inoue, Hiroaki Shimizu, Akira Takahashi, Teiji Tominaga

NEUROSURGICAL FOCUS　34　(1)　131-139　2013年1月

DOI： 10.3171/2012.9.JNS12566 　

ISSN：1092-0684
Medullary infarction as a poor prognostic factor after internal coil trapping of a ruptured vertebral artery dissection Clinical article 査読有り

Hidenori Endo, Yasushi Matsumoto, Ryushi Kondo, Kenichi Sato, Miki Fujimura, Takashi Inoue, Hiroaki Shimizu, Akira Takahashi, Teiji Tominaga

JOURNAL OF NEUROSURGERY　118　(1)　131-139　2013年1月

DOI： 10.3171/2012.9.JNS12566 　

ISSN：0022-3085
Required knowledge for neuroendovascular surgeon (4) basic technique of the coil embolization and parent artery occlusion for cerebral aneurysms 査読有り

Hidenori Endo, Yasushi Matsumoto, Ryushi Kondo, Ichiro Suzuki, Toshio Kikuchi, Teiji Tominaga

Neurological Surgery　40　(12)　1107-1118　2012年12月

ISSN：0301-2603 1882-1251
Involvement of Mitogen-Activated Protein Kinase Pathways in Expression of the Water Channel Protein Aquaporin-4 after Ischemia in Rat Cortical Astrocytes 査読有り

Chikako Nito, Hiroshi Kamada, Hidenori Endo, Purnima Narasimhan, Yong-Sun Lee, Pak H. Chan

JOURNAL OF NEUROTRAUMA　29　(14)　2404-2412　2012年9月

DOI： 10.1089/neu.2012.2430 　

ISSN：0897-7151

eISSN：1557-9042
Coexistence of Sporadic Cerebellar Hemangioblastoma and Pituitary Null Cell Adenoma: Simultaneous Expression of von Hippel-Lindau Gene Product -Case Report- 査読有り

Yoshiteru Shimoda, Yoshikazu Ogawa, Hidenori Endo, Mika Watanabe, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　52　(8)　591-594　2012年8月

DOI： 10.2176/nmc.52.591 　

ISSN：0470-8105
Tuberothalamic Artery Infarctions following Coil Embolization of Ruptured Posterior Communicating Artery Aneurysms with Posterior Communicating Artery Sacrifice 査読有り

H. Endo, K. Sato, R. Kondo, Y. Matsumoto, A. Takahashi, T. Tominaga

AMERICAN JOURNAL OF NEURORADIOLOGY　33　(3)　500-506　2012年3月

DOI： 10.3174/ajnr.A2828 　

ISSN：0195-6108
Disappearance of microembolic signals on transcranial doppler after carotid artery stenting: A case report 査読有り

Ryushi Kondo, Yasushi Matsumoto, Kenichi Sato, Hidenori Endo, Shoichiro Sato, Eisuke Furui, Ryo Itabashi, Yukako Yazawa, Satoru Fujiwara, Akira Takahashi, Teiji Tominaga

Journal of Neuroendovascular Therapy　6　(2)　114-121　2012年

DOI： 10.5797/jnet.6.114 　

ISSN：2186-2494 1882-4072
Subarachnoid Hemorrhage Due to Ruptured Posterior Cerebral Artery Aneurysm Simultaneously Associated With Multiple Remote Intracerebral Hemorrhages-Case Report 査読有り

Shinya Sonobe, Miki Fujimura, Hidenori Endo, Takashi Inoue, Hiroaki Shimizu, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　51　(12)　836-838　2011年12月

DOI： 10.2176/nmc.51.836 　

ISSN：0470-8105
Extradural dermoid cyst of the parasellar region: a case report. 査読有り

Endo H, Murakami K, Watanabe M, Tominaga T

Skull base reports　1　(1)　3-6　2011年5月

DOI： 10.1055/s-0030-1263284 　

ISSN：2157-6971
Simultaneous Occurrence of Subarachnoid Hemorrhage and Epistaxis Due to Ruptured Petrous Internal Carotid Artery Aneurysm: Association With Transsphenoidal Surgery and Radiation Therapy-Case Report 査読有り

Hidenori Endo, Miki Fujimura, Takashi Inoue, Yasushi Matsumoto, Yoshikazu Ogawa, Jun Kawagishi, Hidefumi Jokura, Hiroaki Shimizu, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　51　(3)　226-229　2011年3月

DOI： 10.2176/nmc.51.226 　

ISSN：0470-8105
Paradoxical Association of Moyamoya Syndrome With Large Middle Cerebral Artery Aneurysm and Subarachnoid Hemorrhage -Case Report 査読有り

Hidenori Endo, Miki Fujimura, Takashi Inoue, Hiroaki Shimizu, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　50　(12)　1088-1091　2010年12月

DOI： 10.2176/nmc.50.1088 　

ISSN：0470-8105
Efficacy of Revascularization Surgery for Moyamoya Syndrome Associated With Graves' Disease 査読有り

Hidenori Endo, Miki Fujimura, Kuniyasu Niizuma, Hiroaki Shimizu, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　50　(11)　977-983　2010年11月

DOI： 10.2176/nmc.50.977 　

ISSN：0470-8105
A Case of Subarachnoid Hemorrhage Complicated by Acquired Hemophilia 査読有り

Ryuta Saito, Toshie Takahashi, Hidenori Endo, Naoto Kimura, Uichi Kaneko

NEUROLOGICAL SURGERY　37　(12)　1215-1219　2009年12月

ISSN：0301-2603
A Case of Repeated Intracerebral Hemorrhage due to a Ruptured Aneurysm of Collateral Circulation from the Posterior Cerebral Artery to the Middle Cerebral Artery 査読有り

Ayumi Narisawa, Toshie Takahashi, Ryuta Saito, Kenichi Sato, Hidenori Endo, Nobuo Noshita, Uichi Kaneko

NEUROLOGICAL SURGERY　37　(8)　787-792　2009年8月

ISSN：0301-2603
Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival 査読有り

Kuniyasu Niizuma, Hidenori Endo, Pak H. Chan

JOURNAL OF NEUROCHEMISTRY　109　133-138　2009年5月

DOI： 10.1111/j.1471-4159.2009.05897.x 　

ISSN：0022-3042
Hemorrhagic onset of pilocytic astrocytoma and pilomyxoid astrocytoma 査読有り

Ichiyo Shibahara, Masayuki Kanamori, Toshihiro Kumabe, Hidenori Endo, Yukihiko Sonoda, Yoshikazu Ogawa, Mika Watanabe, Teiji Tominaga

BRAIN TUMOR PATHOLOGY　26　(1)　1-5　2009年4月

DOI： 10.1007/s10014-008-0243-7 　

ISSN：1433-7398
Application of high-definition flexible neuroendoscopic system to the treatment of primary pineal malignant B-cell lymphoma 査読有り

Hidenori Endo, Miki Fujimura, Toshihiro Kumabe, Masayuki Kanamori, Mika Watanabe, Teiji Tominaga

SURGICAL NEUROLOGY　71　(3)　344-348　2009年3月

DOI： 10.1016/j.surneu.2007.08.029 　

ISSN：0090-3019
Potential Role of PUMA in Delayed Death of Hippocampal CA1 Neurons After Transient Global Cerebral Ischemia 査読有り

Kuniyasu Niizuma, Hidenori Endo, Chikako Nito, D. Jeannie Myer, Pak H. Chan

STROKE　40　(2)　618-625　2009年2月

DOI： 10.1161/STROKEAHA.108.524447 　

ISSN：0039-2499
Transient global cerebral ischemia model in mice 査読有り

Kuniyasu Niizuma, Hidenori Endo, Chikako Nito, D. Jeannie Myer, Gab Seok Kim, Teiji Tominaga, Pak H. Chan

Animal Models of Acute Neurological Injuries　115-125　2009年
出版者・発行元： Humana Press
DOI： 10.1007/978-1-60327-185-1_10 　
Neuro-endoscopic management of mesencephalic intraparenchymal cyst: a case report 査読有り

Hidenori Endo, Miki Fujimura, Mika Watanabe, Teji Tominaga

SURGICAL NEUROLOGY　71　(1)　107-110　2009年1月

DOI： 10.1016/j.surneu.2007.07.037 　

ISSN：0090-3019
Role of the p38 mitogen-activated protein kinase/cytosolic phospholipase A(2) signaling pathway in blood-brain barrier disruption after focal cerebral ischemia and reperfusion 査読有り

Chikako Nito, Hiroshi Kamada, Hidenori Endo, Kuniyasu Niizuma, D. Jeannie Myer, Pak H. Chan

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　28　(10)　1686-1696　2008年10月

DOI： 10.1038/jcbfm.2008.60 　

ISSN：0271-678X
The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats 査読有り

Kuniyasu Niizuma, Hidenori Endo, Chikako Nito, D. Jeannie Myer, Gab Seok Kim, Pak H. Chan

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　105　(42)　16368-16373　2008年10月

DOI： 10.1073/pnas.0806222105 　

ISSN：0027-8424
Induction of MMP-9 expression and endothelial injury by oxidative stress after spinal cord injury 査読有り

Fengshan Yu, Hiroshi Kamada, Kuniyasu Niizuma, Hidenori Endo, Pak H. Chan

JOURNAL OF NEUROTRAUMA　25　(3)　184-195　2008年3月

DOI： 10.1089/neu.2007.0438 　

ISSN：0897-7151
Reduction in oxidative stress by superoxide dismutase overexpression attenuates acute brain injury after subarachnoid hemorrhage via activation of Akt/glycogen synthase kinase-3 beta survival signaling 査読有り

Hidenori Endo, Chikako Nito, Hiroshi Kamada, Fengshan Yu, Pak H. Chan

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　27　(5)　975-982　2007年5月

DOI： 10.1038/sj.jcbfm.9600399 　

ISSN：0271-678X
Bad as a converging signaling molecule between survival PI3-K/Akt and death JNK in neurons after transient focal cerebral ischemia in rats 査読有り

Hiroshi Kamada, Chikako Nito, Hidenori Endo, Pak H. Chan

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　27　(3)　521-533　2007年3月

DOI： 10.1038/sj.jcbfm.9600367 　

ISSN：0271-678X
Mitochondrial translocation of p53 underlies the selective death of hippocampal CA1 neurons after global cerebral ischaemia (Biochemical Society Transactions (2006) 34, PART 6 (1283-1286))

Endo, H., Saito, A., Chan, P.H.

Biochemical Society Transactions　35　(6)　1649-1649　2007年

DOI： 10.1042/BST0351649 　

ISSN：0300-5127
Reduction in oxidative stress by SOD1 overexpression attenuates acute brain injury after subarachnoid hemorrhage via activation of Akt/GSK3b survival signaling

Endo, H., Niizuma, K., Fujimura, M., Tominaga, T., Chan, P.H.

Journal of Cerebral Blood Flow and Metabolism　27　(SUPPL. 1)　2007年

ISSN：0271-678X
PUMA is involved in acute brain injury after subarachnoid hemorrhage in rats

Niizuma, K., Endo, H., Fujimura, M., Tominaga, T., Chan, P.H.

Journal of Cerebral Blood Flow and Metabolism　27　(SUPPL. 1)　2007年

ISSN：0271-678X
Activation of the Akt/GSK3 beta signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats 査読有り

Hidenori Endo, Chikako Nito, Hiroshi Kamada, Tatsuro Nishi, Pak H. Chan

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　26　(12)　1479-1489　2006年12月

DOI： 10.1038/sj.jcbfm.9600303 　

ISSN：0271-678X
Akt/GSK3 beta survival signaling is involved in acute brain injury after subarachnoid hemorrhage in rats 査読有り

Hidenori Endo, Chikako Nito, Hiroshi Kamada, Fengshan Yu, Pak H. Chan

STROKE　37　(8)　2140-2146　2006年8月

DOI： 10.1161/01.STR.0000229888.55078.72 　

ISSN：0039-2499
Mitochondrial translocation of p53 mediates release of cytochrome c and hippocampal CA1 neuronal death after transient global cerebral ischemia in rats 査読有り

Hidenori Endo, Hiroshi Kamada, Chikako Nito, Tatsuro Nishi, Pak H. Chan

JOURNAL OF NEUROSCIENCE　26　(30)　7974-7983　2006年7月

DOI： 10.1523/JNEUROSCI.0897-06.2006 　

ISSN：0270-6474
Mild hypoxia promotes survival and proliferation of SOD2-deficient astrocytes via c-Myc activation 査読有り

J Liu, P Narasimhan, YS Lee, YS Song, H Endo, FS Yu, PH Chan

JOURNAL OF NEUROSCIENCE　26　(16)　4329-4337　2006年4月

DOI： 10.1523/JNEUROSCI.0382-06.2006 　

ISSN：0270-6474
Mitochondrial translocation of p53 underlies the selective death of hippocampal CA1 neurons after global cerebral ischaemia

Endo, H., Saito, A., Chan, P.H.

Biochemical Society Transactions　34　(6)　2006年

DOI： 10.1042/BST0341283 　

ISSN：0300-5127
Paraparesis associated with ruptured anterior cerebral artery territory aneurysms 査読有り

H Endo, H Shimizu, T Tominaga

SURGICAL NEUROLOGY　64　(2)　135-139　2005年8月

DOI： 10.1016/j.surneu.2004.12.019 　

ISSN：0090-3019
Stereotactic radiosurgery followed by whole ventricular irradiation for primary intracranial germinoma of the pineal region 査読有り

H Endo, T Kumabe, H Jokura, T Tominaga

MINIMALLY INVASIVE NEUROSURGERY　48　(3)　186-190　2005年6月

DOI： 10.1055/s-2004-830263 　

ISSN：0946-7211
Thoracic intradural arachnoid cyst associated with surgical removal of epidural hematoma - Case report 査読有り

H Endo, T Takahashi, H Shimizu, T Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　44　(11)　607-610　2004年11月

DOI： 10.2176/nmc.44.607 　

ISSN：0470-8105
Stereotactic radiosurgery for nodular dissemination of anaplastic ependymoma 査読有り

H. Endo, Toshihiro Kumabe, H. Jokura, R. Shirane, T. Tominaga, Eirik Helseth, Kintomo Takakura

Acta Neurochirurgica　146　(3)　291-298　2004年3月

DOI： 10.1007/s00701-003-0208-x 　

ISSN：0001-6268
Single burr hole surgery for acute spontaneous subdural hematoma in the aged: Patient reports of three cases 査読有り

H Endo, O Fukawa, S Mashiyama, M Kawase

NEUROLOGICAL SURGERY　32　(3)　271-276　2004年3月

ISSN：0301-2603
Leptomeningeal dissemination of cerebellar malignant astrocytomas 査読有り

H Endo, T Kumabe, H Jokura, R Shirane, H Ariga, Y Takai, T Yoshimoto

JOURNAL OF NEURO-ONCOLOGY　63　(2)　191-199　2003年6月

DOI： 10.1023/a:1023983518341 　

ISSN：0167-594X
[Transient hyperintensity lesions on diffusion-weighted MRI in the bilateral internal capsules due to hypoglycemic coma]. 査読有り

Endo H, Shimizu H, Tominaga T, Yoshimoto T

No to shinkei = Brain and nerve　55　(2)　174-175　2003年2月

ISSN：0006-8969
A case of primary cerebellar glioblastoma in childhood 査読有り

H Endo, T Kumabe, H Kon, T Yoshimoto, Y Nakasato

NEUROLOGICAL SURGERY　30　(12)　1325-1329　2002年12月

ISSN：0301-2603

︎全件表示 ︎最初の5件までを表示

MISC 332

破裂脳動脈瘤治療におけるMRI瘤壁造影効果の有用性-VWIによる破裂部位・破裂点同定と診断ピットフォール克服-

面高俊介, 鹿毛淳史, 坂田洋之, 遠藤英徳

日本脳神経CI学会総会プログラム・抄録集　49th　2026年
出血発症AVM急性期治療における血管内治療の役割

面高俊介, 鹿毛淳史, 坂田洋之, 遠藤英徳

Neurosurgical Emergency　30　(3)　2026年

ISSN： 1342-6214
てんかん患者に対するテキストベース遠隔心理支援の可能性

小川舞美, 浮城一司, 藤川真由, 亀井幹子, 小木曽由佳, 古村智, 遠藤英徳, 中里信和, 神一敬

てんかん研究　43　(2)　2025年

ISSN： 0912-0890
選択的脳領域麻酔による新規機能マッピング法の確立

大沢伸一郎, 鈴木匡子, 柿沼一雄, 菊地花, 浮城一司, 石田誠, 勝瀬一登, 太田祥子, 下田由輝, 新妻邦泰, 新妻邦泰, 新妻邦泰, 神一敬, 遠藤英徳

臨床神経生理学(Web)　53　(5)　2025年

ISSN： 2188-031X
機能リスクから考察する島回-弁蓋部てんかんの直達外科治療

大沢伸一郎, 浮城一司, 柿沼一雄, 石田誠, 菊地花, 下田由輝, 神一敬, 植松貢, 鈴木匡子, 遠藤英徳

てんかん研究　43　(2)　2025年

ISSN： 0912-0890
選択的脳領域麻酔による新規脳機能マッピング法の確立

大沢伸一郎, 鈴木匡子, 柿沼一雄, 菊地花, 浮城一司, 石田誠, 勝瀬一登, 太田祥子, 下田由輝, 金森政之, 新妻邦泰, 新妻邦泰, 新妻邦泰, 松本康史, 松本康史, 神一敬, 遠藤英徳

てんかん研究　43　(2)　2025年

ISSN： 0912-0890
数字優位の純粋失読を呈した左後頭頭頂葉切除後の一例

太田祥子, 勝瀬一登, 勝瀬一登, 伊関千書, 森山さや香, 下田由輝, 金森政之, 柿沼一雄, 川上暢子, 菅野重範, 遠藤英徳, 松田実, 鈴木匡子

日本神経心理学会学術集会(Web)　49th　2025年
側頭葉てんかん患者におけるレミマゾラム麻酔が皮質脳波および運動誘発電位に及ぼす影響

浮城一司, 大沢伸一郎, 鎌田ことえ, 佐藤貴文, 山内正憲, 遠藤英徳, 中里信和

日本てんかん外科学会プログラム・抄録集　48th　2025年
両側性の側頭葉言語機能局在を証明し,意図的な遠隔部位追加切除を行った右後頭側頭葉てんかんの一例

二宮敦彦, 大沢伸一郎, 鈴木匡子, 柿沼一雄, 浮城一司, 鈴木博義, 中里信和, 遠藤英徳

日本てんかん外科学会プログラム・抄録集　48th　2025年
血管内治療手技の応用による多面的脳機能リスク評価

大沢伸一郎, 鈴木匡子, 柿沼一雄, 菊地花, 浮城一司, 石田誠, 勝瀬一登, 金森政之, 下田由輝, 二宮敦彦, 太田祥子, 新妻邦泰, 新妻邦泰, 新妻邦泰, 松本康史, 松本康史, 中里信和, 遠藤英徳

日本てんかん外科学会プログラム・抄録集　48th　2025年
後大脳動脈選択的麻酔薬注入による記憶側性化評価は術後の言語性記憶低下を予測する

菊地花, 大沢伸一郎, 柿沼一雄, 勝瀬一登, 勝瀬一登, 太田祥子, 浮城一司, 神一敬, 遠藤英徳, 中里信和, 鈴木匡子

日本てんかん外科学会プログラム・抄録集　48th　2025年
選択的脳領域麻酔にともなう脳波変化はてんかん原性領域の診断的価値を持つ

石田誠, 大沢伸一郎, 菊地花, 浮城一司, 神一敬, 鈴木匡子, 遠藤英徳, 中里信和

日本てんかん外科学会プログラム・抄録集　48th　2025年
てんかん外科治療後に生じた心因性非てんかん発作の臨床像

小川舞美, 大沢伸一郎, 岩城弘隆, 秋月祐子, 藤川真由, 浮城一司, 下田由輝, 神一敬, 富田博秋, 遠藤英徳, 中里信和

日本てんかん外科学会プログラム・抄録集　48th　2025年
【ITを駆使した術前シミュレーション-トラブル回避と時短手術習得】合併症対策のための術前シミュレーション脳動脈瘤開頭クリッピング術

内田浩喜, 遠藤英徳

Neurological Surgery　52　(2)　374-379　2024年3月
出版者・発行元： (株)医学書院
ISSN： 0301-2603

eISSN： 1882-1251
左側頭葉病変による漢字の失書の発症機序内省も含めた検討

森田亜由美, 遠藤佳子, 金森政之, 遠藤英徳, 鈴木匡子

高次脳機能研究　44　(1)　67-67　2024年3月
出版者・発行元： (一社)日本高次脳機能学会
ISSN： 1348-4818

eISSN： 1880-6554
超選択的Wadaテストで外側皮質言語機能と言語性記銘力の側方性不一致が示された側頭葉てんかんの一例

柿沼一雄, 大沢伸一郎, 浮城一司, 土屋真理夫, 太田祥子, 遠藤英徳, 中里信和, 鈴木匡子

高次脳機能研究　44　(1)　78-79　2024年3月
出版者・発行元： (一社)日本高次脳機能学会
ISSN： 1348-4818

eISSN： 1880-6554
超選択的Wadaテストにより非典型的側性化が明らかになった難治性てんかん患者の1例

菊地花, 大沢伸一郎, 浮城一司, 柿沼一雄, 勝瀬一登, 太田祥子, 川村藍, 劉軍艶, 遠藤英徳, 中里信和, 鈴木匡子

高次脳機能研究　44　(1)　79-79　2024年3月
出版者・発行元： (一社)日本高次脳機能学会
ISSN： 1348-4818

eISSN： 1880-6554
脳外科診療パフォーマンス向上とWork Life Balance コア・コンピタンス-能力・人材の活かし方、仕事との向き合い方- 脳神経外科医の知識・技術・度胸は救急現場で重宝される

横沢路子, 梶谷卓未, 梅澤邦彦, 木村尚人, 須原誠, 遠藤英徳

Neurosurgical Emergency　28　(3)　269-269　2024年2月
出版者・発行元： (NPO)日本脳神経外科救急学会
ISSN： 1342-6214
【脳神経内科領域におけるSociety 5.0】Society 5.0のデザインと脳神経内科

中川敦寛, 原田成美, 櫻井碧, 柳澤祐太, 遠藤英徳

脳神経内科　100　(2)　168-175　2024年2月
出版者・発行元： (有)科学評論社
ISSN： 2434-3285
術前・術中画像診断に基づく戦略的血栓回収療法

坂田洋之, 坂田洋之, 佐藤健一, 江面正幸, 矢澤由加子, 遠藤英徳

日本血管内治療学会学術総会プログラム・抄録集　30th　2024年
Spheno-orbital meningiomaの2例

内田浩喜, 面高俊介, 鹿毛淳史, 坂田洋之, 川口奉洋, 遠藤英徳

日本頭蓋底外科学会プログラム・抄録集　36th　2024年
高齢者もやもや病の病態と血行再建術

鹿毛淳史, 内田浩喜, 田代亮介, 坂田洋之, 新妻邦泰, 新妻邦泰, 遠藤英徳

脳循環代謝(Web)　36　(1)　2024年

ISSN： 2188-7519
頚動脈ステント留置術後過灌流予防のためのエダラボン術前投与

井上敬, 大友智, 庄司薫, 佐藤健一, 坂田洋之, 遠藤英徳

脳循環代謝(Web)　36　(1)　2024年

ISSN： 2188-7519
フローダイバーター治療戦略のパラダイムシフト:DSAを用いた脳循環解析による術中動脈瘤閉塞予測

坂田洋之, 坂田洋之, 針生新也, 田代亮介, 鹿毛淳史, 内田浩喜, 遠藤英徳

脳循環代謝(Web)　36　(1)　2024年

ISSN： 2188-7519
Trans-sellar anastomosisの温存を要した内頚動脈無形成併発下垂体神経内分泌腫瘍の一例

田代亮介, 川口奉洋, 石田朋久, 坂田洋之, 和泉健大龍, 渡邊裕文, 渡邊みか, 遠藤英徳

日本神経内視鏡学会プログラム・抄録集　31st　2024年
顔面けいれんに対する内視鏡下微小血管減圧術

内田浩喜, 川口奉洋, 田代亮介, 鹿毛淳史, 坂田洋之, 遠藤英徳

日本神経内視鏡学会プログラム・抄録集　31st　2024年
エダラボン術前投与による頚動脈ステント留置術後過灌流予防

井上敬, 大友智, 庄司薫, 佐藤健一, 坂田洋之, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集(Web)　40th　2024年

ISSN： 2759-6907
フローダイバーター治療戦略のパラダイムシフト:DSAを用いた脳循環解析による術中動脈瘤閉塞予測

坂田洋之, 坂田洋之, 針生新也, 田代亮介, 田代亮介, 鹿毛敦史, 内田浩喜, 松本康史, 松本康史, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集(Web)　40th　2024年

ISSN： 2759-6907
脳血管内治療の最前線と近未来脳動静脈奇形治療の最前線

坂田洋之, 坂田洋之, 遠藤英徳

医学のあゆみ　291　(7)　2024年

ISSN： 0039-2359
外傷性脳損傷に対するMuse細胞治療の有効性の探索

永井新, 永井新, 中屋敷諄, 中屋敷諄, 北村祐樹, 北村祐樹, 安藤大祐, RASHAD Sherif, RASHAD Sherif, 金森正之, 遠藤英徳, 新妻邦泰, 新妻邦泰, 新妻邦泰

日本分子脳神経外科学会プログラム・抄録集　24th　2024年
治療後遠隔期に中枢神経外多発骨・骨髄転移再発を来した髄芽腫の一例

戒能明, 入江正寛, 岩淵蒼太, 中野智太, 鈴木資, 片山紗乙莉, 新妻秀剛, 下田由輝, 金森政之, 遠藤英徳, 笹原洋二, 菊池敦生

日本小児血液・がん学会雑誌(Web)　61　(1)　2024年

ISSN： 2189-5384
てんかん焦点切除後に書字への関心が顕著となった自閉症スペクトラムの一例

柿沼一雄, 大沢伸一郎, 曽我天馬, 浮城一司, 神一敬, 勝瀬一登, 勝瀬一登, 森田亜由美, 遠藤佳子, 遠藤英徳, 中里信和, 鈴木匡子

日本神経精神医学会学術集会プログラム・抄録集　29th (CD-ROM)　2024年
左側頭葉新皮質病変を伴うてんかんにおける発作時心拍上昇率の比較

高野歩有, 浮城一司, 曽我天馬, 神一敬, 板橋泉, 大沢伸一郎, 大沢伸一郎, 岩崎真樹, 遠藤英徳, 中里信和

臨床神経生理学(Web)　52　(5)　2024年

ISSN： 2188-031X
心房細動に対する完全胸腔鏡下左心耳閉鎖術とハイブリッドアブレーションの可能性と展望

佐藤宏行, 中野誠, 野田崇, 細山勝寛, 齋木佳克, 新妻邦泰, 遠藤英徳, 安田聡

日本心臓病学会学術集会(Web)　72nd　2024年
後大脳動脈への超選択的麻酔薬注入による記憶機能のカテゴリ別評価

大沢伸一郎, 鈴木匡子, 柿沼一雄, 勝頼一登, 菊地花, 浮城一司, 石田誠, 新妻邦泰, 新妻邦泰, 神一敬, 中里信和, 遠藤英徳

日本ヒト脳機能マッピング学会プログラム・抄録集　26th　2024年
ハイドロゲル-有機物を基材とする新規頭蓋内電極の安全性と有効性-医師主導治験による検証-

大沢伸一郎, 新妻邦泰, 中川敦寛, 新妻邦泰, 中川敦寛, 浮城一司, 下田由輝, 神一敬, 植松貢, 岩崎真樹, 西澤松彦, 中里信和, 冨永悌二, 遠藤英徳

日本てんかん外科学会プログラム・抄録集　47th　2024年
中心溝周囲皮質のてんかん焦点切除症例における画像所見と運動機能低下の相関

二宮敦彦, 大沢伸一郎, 鈴木匡子, 柿沼一雄, 浮城一司, 下田由輝, 鈴木博義, 宮田元, 神一敬, 植松貢, 中里信和, 遠藤英徳

日本てんかん外科学会プログラム・抄録集　47th　2024年
音で誘発される全般強直発作に全脳梁離断術が有効であった1例

浮城一司, 大沢伸一郎, 柿坂庸介, 神一敬, 冨永悌二, 遠藤英徳, 中里信和

日本てんかん外科学会プログラム・抄録集　47th　2024年
産学連携における最新の動向

中川敦寛, Leor Perl, John Lee, 原田成美, 大田千晴, 志賀卓弥, 角南沙己, 新妻邦泰, 遠藤英徳, 張替秀郎, 冨永悌二

Neurological Surgery　52　(1)　213-225　2024年1月
出版者・発行元： (株)医学書院
ISSN： 0301-2603

eISSN： 1882-1251
知の発信不随意運動症の最新技術遠隔プログラミングシステムNeurosphere VCの使用経験

永松謙一, 武田篤, 馬場徹, 安藤肇史, 仁村太郎, 遠藤英徳

日本定位・機能神経外科学会プログラム・抄録集　63回　88-88　2024年1月
出版者・発行元： (一社)日本定位・機能神経外科学会
集束超音波治療においてやり直し治療を必要とした症例の原因とその対応

仁村太郎, 安藤肇史, 北澤哲也, 成田行治, 遠藤英徳

日本定位・機能神経外科学会プログラム・抄録集　63回　126-126　2024年1月
出版者・発行元： (一社)日本定位・機能神経外科学会
脳血管障害・良性腫瘍手術における止血マネジメント

鹿毛淳史, 遠藤英徳

日本定位・機能神経外科学会プログラム・抄録集　63回　154-154　2024年1月
出版者・発行元： (一社)日本定位・機能神経外科学会
当院における頭部顔面外傷患者の救急受診状況と治療経過の検証

横沢路子, 木村尚人, 須原誠, 遠藤英徳

日本救急医学会雑誌　34　(12)　739-739　2023年12月
出版者・発行元： (一社)日本救急医学会
ISSN： 0915-924X

eISSN： 1883-3772
【臨床脳腫瘍学-最新の診断・治療と病態-】脳腫瘍の治療脳腫瘍の放射線療法・他腫瘍治療電場併用療法

金森政之, 下田由輝, 遠藤英徳

日本臨床　81　(増刊9 臨床脳腫瘍学)　413-417　2023年12月
出版者・発行元： (株)日本臨床社
ISSN： 0047-1852
【臨床脳腫瘍学-最新の診断・治療と病態-】脳腫瘍の治療脳腫瘍関連合併症脳腫瘍と静脈血栓塞栓症

下田由輝, 金森政之, 遠藤英徳

日本臨床　81　(増刊9 臨床脳腫瘍学)　498-502　2023年12月
出版者・発行元： (株)日本臨床社
ISSN： 0047-1852
「くも膜下出血診療の最前線」クラゾセンタン単剤プロトコール導入によるくも膜下出血術後管理

遠藤英徳, 坂田洋之, 鹿毛淳史, 内田浩喜, 面高俊介, 新妻邦泰

脳循環代謝　35　(1)　41-41　2023年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
「細胞療法update」中枢神経疾患に対するMuse細胞治療

新妻邦泰, 遠藤英徳, 冨永悌二

脳循環代謝　35　(1)　43-43　2023年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
「Neurovascular unit/Neurovasculome」脳血管障害・認知症に対するミトコンドリア転移を用いた神経保護・神経再生療法の開発

田代亮介, Bautisca-Garrido Jesus, 尾崎弾, Sun Guanghua, Obertas Lidiya, Mobley Alexis S., Kim Gab Seok, Aronowski Jaroslow, Jung Joo Eun, 遠藤英徳, 新妻邦泰, 冨永悌二

脳循環代謝　35　(1)　54-54　2023年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
脳動脈瘤出血点予測における瘤壁造影効果の有用性

面高俊介, 坂田洋之, 杉山慎一郎, 新妻邦泰, 遠藤英徳

脳循環代謝　35　(1)　79-79　2023年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
チマメ状動脈瘤破裂によるくも膜下出血に対するhigh flow bypass後の血行動態

鹿毛淳史, 内田浩喜, 坂田洋之, 新妻邦泰, 遠藤英徳

脳循環代謝　35　(1)　84-84　2023年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
慢性硬膜下血腫術後脳循環評価

井上敬, 大友智, 遠藤英徳

脳循環代謝　35　(1)　99-99　2023年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
てんかん発作時と非発作時の脳血管撮影所見の比較

油川大輝, 鹿毛淳史, 内田浩喜, 川口奉洋, 坂田洋之, 鈴木一郎, 遠藤英徳

脳循環代謝　35　(1)　100-100　2023年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
複数回の血管内再治療を要した放射線誘発頸動脈狭窄症の2例

内田浩喜, 鹿毛淳史, 矢澤由加子, 坂田洋之, 松本康史, 新妻邦泰, 遠藤英徳

脳循環代謝　35　(1)　120-120　2023年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
IC-Pcom動脈瘤は血管内治療で制圧できるか内頸動脈後交通動脈分岐部動脈瘤に対する血管内治療 vessel wall imagingによる難治例予測と治療戦略の提唱

坂田洋之, 内田浩喜, 眞野唯, 鹿毛淳史, 新保大輔, 松本康史, 遠藤英徳

脳血管内治療　8　(Suppl.)　S42-S42　2023年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
脳神経血管内治療とAI:診断～治療まで JR-NET3のAI解析

園部真也, 永井新, 新妻邦泰, 坂井信幸, 坂井千秋, 飯原弘二, 佐藤徹, 今村博敏, 石川哲朗, 川上英良, 植田琢也, 遠藤英徳

脳血管内治療　8　(Suppl.)　S65-S65　2023年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
脳AVMに対する血管内治療の進歩と調和未破裂AVMに対する複合的治療戦略直達術者の観点から

遠藤英徳

脳血管内治療　8　(Suppl.)　S75-S75　2023年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
中大脳動脈瘤治療における瘤壁造影効果と虚血性合併症の関連

鹿毛淳史, 坂田洋之, 内田浩喜, 面高俊介, 新妻邦泰, 松本康史, 遠藤英徳

脳血管内治療　8　(Suppl.)　S210-S210　2023年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
教師なし学習によるIC-Pcom動脈瘤の形態的クラスタリング血管内治療後の再発との関係性

内田浩喜, 杉山慎一郎, 鹿毛淳史, 坂田洋之, 遠藤英徳

脳血管内治療　8　(Suppl.)　S214-S214　2023年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
動眼神経麻痺で発症した未破裂内頸動脈-後交通動脈分岐部動脈瘤の瘤壁造影効果

面高俊介, 坂田洋之, 新妻邦泰, 松本康史, 遠藤英徳

脳血管内治療　8　(Suppl.)　S214-S214　2023年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
大型動脈瘤に対するFlow Diverterによる治療成績 vessel wall imagingによる難治例の予測は可能か

新保大輔, 坂田洋之, 眞野唯, 鹿毛淳史, 内田浩喜, 松本康史, 藤村幹, 遠藤英徳

脳血管内治療　8　(Suppl.)　S334-S334　2023年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
57歳血管内治療学会3年目医師が考察する血管内治療養成の問題点

井上敬, 大友智, 遠藤英徳

脳血管内治療　8　(Suppl.)　S388-S388　2023年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
SHAP(SHapley Additive exPlanations)解析によるCEA/CASの決定過程の可視化

内田浩喜, 鹿毛淳史, 面高俊介, 坂田洋之, 遠藤英徳

脳血管内治療　8　(Suppl.)　S512-S512　2023年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
脳腫瘍の塞栓術と摘出術を行う脳神経外科医の新たな二刀流について

伊藤明, 新妻邦泰, 遠藤俊毅, 遠藤英徳

脳血管内治療　8　(Suppl.)　S557-S557　2023年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
MeVOに対する機械的血栓回収療法における治療方法の比較検討

相川享, 木村尚人, 町田哲樹, 井上学, 園田卓司, 滝川浩平, 梶谷卓未, 横沢路子, 梅澤邦彦, 菊池貴彦, 遠藤英徳

脳血管内治療　8　(Suppl.)　S664-S664　2023年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
脳血栓回収療法後過還流を来した2例

永井友仁, 佐藤加奈子, 木村健介, 鈴木一郎, 遠藤英徳

脳血管内治療　8　(Suppl.)　S684-S684　2023年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
【二刀流術者のための脳血管障害手術テキスト】(Chapter 3)機器・デバイスを知る直達術者が二刀流術者に知っておいてほしい機器・デバイス Yasargilクリップ・杉田クリップ・Dクリップ

内田浩喜, 遠藤英徳

脳神経外科速報　(2023増刊)　46-50　2023年10月
出版者・発行元： (株)メディカ出版
ISSN： 0917-1495
【くも膜下出血の今】くも膜下出血急性期の治療開頭術

鹿毛淳史, 遠藤英徳

Clinical Neuroscience　41　(10)　1292-1295　2023年10月
出版者・発行元： (株)中外医学社
ISSN： 0289-0585
MCSにおける脳合併症を本気で考える脳合併症に対する外科的治療、開頭術の基準とは

大沢伸一郎, 斎木佳克, 遠藤英徳

日本胸部外科学会定期学術集会　76回　CPD4-6　2023年10月
出版者・発行元： (一社)日本胸部外科学会
SMTPによる新規血栓溶解剤の開発と実用化に向けて

新妻邦泰, 遠藤英徳, 冨永悌二

臨床神経学　63　(Suppl.)　S27-S27　2023年9月
出版者・発行元： (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
膠芽腫に対する青色光単独治療への試み

山下将太, 下田由輝, 金森政之, 遠藤英徳, 新妻邦泰

日本レーザー医学会誌　44　(3)　311-311　2023年9月
出版者・発行元： (NPO)日本レーザー医学会
ISSN： 0288-6200

eISSN： 1881-1639
脳血管の生理/病理と治療薬剤の作用機序くも膜下出血後脳血管攣縮に対するクラゾセンタンの有効性

遠藤英徳, 萩原靖, 瀧澤克己, 木村尚人, 新妻邦泰, 冨永悌二

くも膜下出血と脳血管攣縮　38　68-68　2023年7月
出版者・発行元： SAH
ISSN： 2759-2405
Basic Neuroscience 画像脳動脈瘤のvessel wall imagingの進歩と有用性

面高俊介, 遠藤英徳, 冨永悌二

Annual Review神経　2023　56-61　2023年6月
出版者・発行元： (株)中外医学社
忘れ得ぬ症例(先達からのメッセージ):神経外傷穿通性脳損傷の臨床

刈部博, 成澤あゆみ, 和泉健大龍, 中川敦寛, 遠藤英徳

Journal of Japan Society of Neurological Emergencies & Critical Care　36　(1)　39-39　2023年6月
出版者・発行元： (株)へるす出版
ISSN： 2433-0485

eISSN： 2433-1600
Basic Neuroscience 画像脳動脈瘤のvessel wall imagingの進歩と有用性

面高俊介, 遠藤英徳, 冨永悌二

Annual Review神経　2023　56-61　2023年6月
出版者・発行元： (株)中外医学社
脳腫瘍診断におけるAIの役割と今後の発展性について【AIによる脳腫瘍の病変自動検出が最初に実用化されると予想しています】

木下学, 遠藤英徳

日本医事新報　(5162)　51-51　2023年4月
出版者・発行元： (株)日本医事新報社
ISSN： 0385-9215
くも膜下出血に対する新しい脳血管攣縮発症抑制薬についてクラゾセンタンが早期承認を経て実臨床において使用可能となった

遠藤英徳, 園田順彦

日本医事新報　(5160)　51-51　2023年3月
出版者・発行元： (株)日本医事新報社
ISSN： 0385-9215
【脳動脈瘤の温故知新現在までの治療を紡ぐ永久保存版】脳血管攣縮の最新治療

遠藤英徳, 新妻邦泰, 冨永悌二

脳神経外科速報　33　(2)　208-210　2023年3月
出版者・発行元： (株)メディカ出版
ISSN： 0917-1495
【出血性脳血管障害】脳動静脈奇形に対する多角的アプローチ

遠藤英徳, 松本康史, 川岸潤, 城倉英史, 冨永悌二

脳神経外科ジャーナル　32　(2)　99-108　2023年2月
出版者・発行元： (一社)日本脳神経外科コングレス
ISSN： 0917-950X
複雑なトルコ鞍近傍腫瘍に対する栄養動脈塞栓術の有効性と限界

川口奉洋, 石田朋久, 鹿毛淳史, 遠藤英徳, 坂田洋之, 小川欣一, 冨永悌二

日本間脳下垂体腫瘍学会プログラム・抄録集　33rd　2023年
クラゾセンタン単剤プロトコール導入によるくも膜下出血術後管理

遠藤英徳, 坂田洋之, 鹿毛淳史, 内田浩喜, 面高俊介, 新妻邦泰

脳循環代謝(Web)　35　(1)　2023年

ISSN： 2188-7519
脳動脈瘤出血点予測における瘤壁造影効果の有用性

面高俊介, 坂田洋之, 杉山慎一郎, 新妻邦泰, 遠藤英徳

脳循環代謝(Web)　35　(1)　2023年

ISSN： 2188-7519
てんかん発作時と非発作時の脳血管撮影所見の比較

油川大輝, 油川大輝, 鹿毛淳史, 内田浩喜, 川口奉洋, 坂田洋之, 鈴木一郎, 遠藤英徳

脳循環代謝(Web)　35　(1)　2023年

ISSN： 2188-7519
チマメ状動脈瘤破裂によるくも膜下出血に対するhigh flow bypass後の血行動態

鹿毛淳史, 内田浩喜, 坂田洋之, 新妻邦泰, 新妻邦泰, 遠藤英徳

脳循環代謝(Web)　35　(1)　2023年

ISSN： 2188-7519
複数回の血管内再治療を要した放射線誘発頚動脈狭窄症の2例

内田浩喜, 鹿毛淳史, 矢澤由加子, 坂田洋之, 坂田洋之, 松本康史, 新妻邦泰, 遠藤英徳

脳循環代謝(Web)　35　(1)　2023年

ISSN： 2188-7519
動眼神経麻痺で発症した未破裂内頚動脈-後交通動脈分岐部動脈瘤の瘤壁造影効果

面高俊介, 坂田洋之, 新妻邦泰, 松本康史, 遠藤英徳

脳血管内治療(Web)　8　(Supplement)　2023年

ISSN： 2424-1709
内頚動脈後交通動脈分岐部動脈瘤に対する血管内治療:vessel wall imagingによる難治例予測と治療戦略の提唱

坂田洋之, 坂田洋之, 内田浩喜, 眞野唯, 鹿毛淳史, 新保大輔, 松本康史, 遠藤英徳

脳血管内治療(Web)　8　(Supplement)　2023年

ISSN： 2424-1709
中大脳動脈瘤治療における瘤壁造影効果と虚血性合併症の関連

鹿毛淳史, 坂田洋之, 内田浩喜, 面高俊介, 新妻邦泰, 新妻邦泰, 松本康史, 遠藤英徳

脳血管内治療(Web)　8　(Supplement)　2023年

ISSN： 2424-1709
教師なし学習によるIC-Pcom動脈瘤の形態的クラスタリング-血管内治療後の再発との関係性-

内田浩喜, 杉山慎一郎, 鹿毛淳史, 坂田洋之, 坂田洋之, 遠藤英徳

脳血管内治療(Web)　8　(Supplement)　2023年

ISSN： 2424-1709
大型動脈瘤に対するFlow Diverterによる治療成績:vessel wall imagingによる難治例の予測は可能か

新保大輔, 坂田洋之, 坂田洋之, 眞野唯, 鹿毛淳史, 内田浩喜, 松本康史, 藤村幹, 遠藤英徳

脳血管内治療(Web)　8　(Supplement)　2023年

ISSN： 2424-1709
SHAP(SHapley Additive exPlanations)解析によるCEA/CASの決定過程の可視化

内田浩喜, 鹿毛淳史, 面高俊介, 坂田洋之, 坂田洋之, 遠藤英徳

脳血管内治療(Web)　8　(Supplement)　2023年

ISSN： 2424-1709
内視鏡下蛍光造影が術中の治療方針選択に有用であった腹側病変を有する頭蓋頚椎移行部動静脈瘻の一例

石田朋久, 石田朋久, 川口奉洋, 鹿毛淳史, 坂田洋之, 遠藤英徳

日本神経内視鏡学会プログラム・抄録集　30th　2023年
術前・術中画像診断に基づく戦略的血栓回収療法

坂田洋之, 遠藤英徳, 矢澤由加子, 冨永悌二

日本血管内治療学会学術総会プログラム・抄録集　29th　2023年
ALKBH1遺伝子のGliomaに対する影響:tRNA修飾によるミトコンドリア機能と幹細胞性の制御

中屋敷諄, 中屋敷諄, RASHAD Sherif, RASHAD Sherif, 永井新, 永井新, MOUSA Abdulrahman, 安藤大祐, 冨永慶太, 冨永慶太, 山下将太, 山下将太, 遠藤英徳, 新妻邦泰, 新妻邦泰, 新妻邦泰

日本分子生物学会年会プログラム・要旨集(Web)　46th　2023年
JR-NET3のAI解析

園部真也, 園部真也, 園部真也, 園部真也, 永井新, 永井新, 新妻邦泰, 新妻邦泰, 新妻邦泰, 新妻邦泰, 坂井信幸, 坂井千秋, 飯原弘二, 佐藤徹, 今村博敏, 石川哲朗, 川上英良, 植田琢也, 遠藤英徳

脳血管内治療(Web)　8　(Supplement)　2023年

ISSN： 2424-1709
PulseRiderを用いた分岐部動脈瘤の中期治療成績従来ステントとの比較

面高俊介, 松本康史, 佐藤健一, 遠藤英徳, 冨永悌二

脳血管内治療　7　(Suppl.)　S2-S2　2022年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
未破裂AVMに対するpost-ARUBA時代の血管内治療戦略

遠藤英徳, 松本康史, 川岸潤, 城倉英史, 冨永悌二

脳血管内治療　7　(Suppl.)　S23-S23　2022年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
CASPER stentの中長期成績

鹿毛淳史, 松本康史, 遠藤英徳, 佐藤健一, 矢澤由加子, 冨永悌二

脳血管内治療　7　(Suppl.)　S41-S41　2022年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
FRED市販後初期使用例の中期成績

森田隆弘, 松本康史, 鹿毛淳史, 面高俊介, 遠藤英徳, 轟和典, 冨永悌二

脳血管内治療　7　(Suppl.)　S128-S128　2022年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
Pipeline shield留置後半年でステント狭窄を認めた海綿静脈洞部内頸動脈瘤の1例

轟和典, 森田隆弘, 松本康史, 鹿毛淳史, 遠藤英徳, 冨永悌二

脳血管内治療　7　(Suppl.)　S212-S212　2022年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
くも膜下出血の病態くも膜下出血後脳血管攣縮に対するクラゾセンタンの有効性

遠藤英徳, 新妻邦泰, 冨永悌二

脳循環代謝　34　(1)　83-83　2022年10月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
3D-ASLと123-IMP SPECTにおけるトレーサーの薬物動態の差異に着目した簡便な脳循環指標の提案

大友一匡, 杉山慎一郎, 遠藤英徳

脳循環代謝　34　(1)　109-109　2022年10月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
もやもや病における深部静脈早期描出と脳循環動態

鹿毛淳史, 遠藤英徳, 冨永悌二

脳循環代謝　34　(1)　122-122　2022年10月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
術後過灌流予測に向けた超音波血流計によるSTA-MCA bypassの血流波形計測

古知龍三郎, 遠藤英徳, 鹿毛敦史, 内田浩喜, 下田由輝, 冨永悌二

脳循環代謝　34　(1)　133-133　2022年10月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
未破裂脳動脈瘤の造影検査と層別化

面高俊介, 遠藤英徳, 冨永悌二

日本脳ドック学会報　8　(2)　36-37　2022年9月
出版者・発行元： (一社)日本脳ドック学会
ISSN： 2189-3128

eISSN： 2758-3821
【脳動脈瘤手術トラブル例若手術者へのアドバイス】前交通動脈瘤(Acom An.)クリッピング術上向き破裂前交通動脈瘤に対するpterional approachでの手術症例

鹿毛淳史, 遠藤英徳

脳神経外科速報　32　(5)　682-692　2022年9月
出版者・発行元： (株)メディカ出版
ISSN： 0917-1495
【感染症-脳神経外科医のためのエッセンス】中枢神経における感染性疾患血管と感染症

鹿毛淳史, 遠藤英徳, 冨永悌二

Neurological Surgery　50　(5)　961-968　2022年9月
出版者・発行元： (株)医学書院
ISSN： 0301-2603

eISSN： 1882-1251
進行性のmyelopathyで発症した三叉神経近傍動静脈奇形の1例

石垣あや, 佐藤和彦, 小川諒, 菊池大一, 小林理子, 中村正史, 宮澤康一, 藤盛寿一, 中島一郎, 佐藤健一, 佐々木達也, 遠藤英徳

臨床神経学　62　(5)　403-403　2022年5月
出版者・発行元： (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
脳幹部海綿状血管腫に対する第四脳室経由摘出術

遠藤俊毅, 藤村幹, 遠藤英徳, 村上謙介, 冨永悌二

脳卒中の外科　50　(2)　130-135　2022年3月
出版者・発行元： (一社)日本脳卒中の外科学会
ISSN： 0914-5508

eISSN： 1880-4683

詳細を見る詳細を閉じる

当院にて第四脳室経由で摘出術を行った脳幹部海綿状血管腫7例の治療成績について検討した。その結果、平均年齢は53.8歳、男性1例、女性6例であった。海綿状血管腫の部位は橋背側4例、延髄背側3例であった。全例で術前なんらかの神経症候を呈していた。6例は病変を全摘出し、すべて症状が改善した。一方、部分摘出となった1例は症状の一部が残存したが、その後は神経症状の悪化なく経過した。術後追跡期間は平均74ヵ月で、最終時のmRSは全例0-2であった。
脳幹部海綿状血管腫に対する第四脳室経由摘出術

遠藤俊毅, 藤村幹, 遠藤英徳, 村上謙介, 冨永悌二

脳卒中の外科　50　(2)　130-135　2022年3月
出版者・発行元： (一社)日本脳卒中の外科学会
ISSN： 0914-5508

eISSN： 1880-4683
未破裂動脈瘤の造影MRI vessel wall imaging stableとunstableの分別に有用な定量的パラメータの分析

森菜緒子, 麦倉俊司, 高瀬圭, 遠藤英徳

Japanese Journal of Radiology　40　(Suppl.)　2-2　2022年2月
出版者・発行元： (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
【脳動脈瘤】脳動脈瘤診断におけるvessel wall imagingの役割

面高俊介, 遠藤英徳, 藤村幹, 冨永悌二

脳神経外科ジャーナル　31　(2)　81-86　2022年2月
出版者・発行元： (一社)日本脳神経外科コングレス
ISSN： 0917-950X
術後過灌流予測に向けた超音波血流計によるSTA-MCA bypassの血流波形計測

古知龍三郎, 遠藤英徳, 鹿毛敦史, 内田浩喜, 下田由輝, 冨永悌二

脳循環代謝(Web)　34　(1)　2022年

ISSN： 2188-7519
高齢者虚血型もやもや病の疫学と治療

藤村幹, 伊東雅基, 杉山拓, 遠藤英徳, 冨永悌二

日本老年脳神経外科学会プログラム・抄録集　35th (CD-ROM)　2022年
脳梗塞:急性期治療治療前CT画像による血栓性状診断血栓回収療法の新たな治療戦略の提唱

坂田洋之, 江面正幸, 石田朋久, 斉藤敦志, 遠藤英徳, 上之原広司, 冨永悌二

脳循環代謝　33　(1)　71-71　2021年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
本学会助成研究の報告 Dual energy CTによる頸動脈プラーク内コレステロール結晶の評価

齋藤拓也, 矢澤由加子, 内田和孝, 宮城樹, 川端雄一, 遠藤英徳, 斉藤敦志, 渡辺みか, 森本剛, 藤村幹

脳循環代謝　33　(1)　77-77　2021年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
Arterial spin labelingのmicro-AVM検出における有用性

古知龍三郎, 遠藤英徳, 内田浩喜, 面高俊介, 松本康史, 冨永悌二

脳循環代謝　33　(1)　84-84　2021年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
治療前CT画像による血栓性状診断血栓回収療法の新たな治療戦略の提唱

坂田洋之, 江面正幸, 石田朋久, 斉藤敦志, 遠藤英徳, 上之原広司, 冨永悌二

脳血管内治療　6　(Suppl.)　S11-S11　2021年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
巨大下垂体腺腫に対する栄養血管塞栓術

藤森健司, 面高俊介, 川口奉洋, 内田浩喜, 遠藤英徳, 松本康史, 冨永悌二

脳血管内治療　6　(Suppl.)　S21-S21　2021年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
未破裂脳動脈瘤におけるVessel wall imagingの新規定量評価法

遠藤英徳, 森菜緒子, 麦倉俊司, 新妻邦泰, 面高俊介, 高瀬圭, 冨永悌二

脳血管内治療　6　(Suppl.)　S39-S39　2021年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
マルチモダリティ時代のYステント支援下瘤内塞栓術

佐藤健一, 松本康史, 遠藤英徳, 冨永悌二

脳血管内治療　6　(Suppl.)　S169-S169　2021年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
傍前床突起部動脈瘤に対する血管内治療

藤森健司, 面高俊介, 内田浩喜, 遠藤英徳, 松本康史, 冨永悌二

脳血管内治療　6　(Suppl.)　S253-S253　2021年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
経動脈的にfistulaを超えてコイルでdrainerを閉塞し根治を得られた円蓋部硬膜動静脈瘻の1例

内田浩喜, 面高俊介, 遠藤英徳, 藤森健司, 松本康史, 冨永悌二

脳血管内治療　6　(Suppl.)　S311-S311　2021年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
エンボスフィアを用いた経動脈的塞栓で根治し得た海綿静脈洞部硬膜動静脈瘻の1例

陳梦格, 大沢伸一郎, 新妻邦泰, 遠藤英徳, 冨永悌二

脳血管内治療　6　(1)　38-43　2021年5月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
拡散テンソル画像を用いた急性期脳卒中片麻痺者における皮質網様体路の損傷度と歩行予後との関連

神将文, 阿部浩明, 遠藤英徳, 藤村幹

理学療法学　48　(2)　163-172　2021年4月
出版者・発行元： (公社)日本理学療法士協会
ISSN： 0289-3770

eISSN： 2189-602X
【脳神経画像Critical Findings-おさえておきたい症状とCT/MRI画像所見】CT/MRIで見落とし・誤認してはいけない疾患 CT isoattenuated/MRI isointense lesions くも膜下出血

遠藤英徳, 藤村幹, 冨永悌二

Neurological Surgery　49　(2)　220-228　2021年3月
出版者・発行元： (株)医学書院
ISSN： 0301-2603

eISSN： 1882-1251
救うぞ!「脳」を(破裂脳動脈瘤)治療戦略破裂急性期脳動脈瘤に対するステント併用コイル塞栓術(第二報)

江面正幸, 坂田洋之, 石田朋久, 遠藤英徳, 井上敬, 上之原広司

Neurosurgical Emergency　25　(3)　474-474　2021年2月
出版者・発行元： (NPO)日本脳神経外科救急学会
ISSN： 1342-6214
治療前CT画像による血栓性状診断:血栓回収療法の新たな治療戦略の提唱

坂田洋之, 江面正幸, 石田朋久, 斉藤敦志, 遠藤英徳, 上之原広司, 冨永悌二

脳循環代謝(Web)　33　(1)　2021年

ISSN： 2188-7519
治療前CT画像による血栓性状診断:血栓回収療法の新たな治療戦略の提唱

坂田洋之, 江面正幸, 石田朋久, 斉藤敦志, 遠藤英徳, 上之原広司, 冨永悌二

脳血管内治療(Web)　6　(Supplement)　2021年

ISSN： 2424-1709
CEA術中ICGによる術後過灌流予測

井上敬, 石田朋久, 坂田洋之, 遠藤英徳, 江面正幸, 上之原広司, 齋藤敦志, 新妻邦泰, 冨永梯二

日本脳神経CI学会総会プログラム・抄録集　44th　2021年
高齢者に対する機械的血栓回収療法の現状

坂田洋之, 江面正幸, 石田朋久, 遠藤英徳, 井上敬, 斉藤敦志, 上之原広司, 冨永悌二

Geriatric Neurosurgery (Web)　34　2021年

ISSN： 2436-6064
Arterial spin labelingのmicro-AVM検出における有用性

古知龍三郎, 遠藤英徳, 内田浩喜, 面高俊介, 松本康史, 冨永悌二

脳循環代謝(Web)　33　(1)　2021年

ISSN： 2188-7519
安定頭蓋内動脈瘤からの不安定頭蓋内動脈瘤の識別における血管壁イメージングの有効定量的パラメータ

MORI Naoko, MUGIKURA Shunji, ENDO Hidenori, SHIMIZU Hiroaki, HIGUCHI Kenichi, TAKAHASHI Shoki, TAKASE Kei

日本医学放射線学会総会抄録集　80th　2021年

ISSN： 0048-0428
エンボスフィアを用いた経動脈的塞栓で根治し得た海綿静脈洞部硬膜動静脈瘻の 1 例

CHEN Mengge, 大沢伸一郎, 新妻邦泰, 遠藤英徳, 冨永悌二

脳血管内治療(Web)　6　(1)　2021年

ISSN： 2424-1709
Multiple Post-Labeling DelayによるASLを用いたCEA周術期脳循環動態評価

遠藤英徳, 藤村幹, 斉藤敦志, 遠藤俊毅, 大友一匡, 井上敬, 江面正幸, 上之原広司, 冨永悌二

脳循環代謝　32　(1)　104-104　2020年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
3D ASL法と123I-IMP SPECT併用による脳血流予備能評価と可能性について

大友一匡, 遠藤英徳, 杉山慎一郎, 藤村幹, 冨永悌二

脳循環代謝　32　(1)　106-106　2020年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
2D perfusion angiographyを用いた頸動脈ステント留置術後の過灌流予測

坂田洋之, 江面正幸, 阿部考貢, 石田朋久, 井上敬, 遠藤英徳, 遠藤俊毅, 冨永悌二

脳血管内治療　5　(Suppl.)　6-6　2020年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
Vessel wall MRIによる脳動脈瘤の瘤壁造影効果脳動脈瘤壁の質的診断

遠藤英徳, 面高俊介, 新妻邦泰, 藤村幹, 佐藤健一, 井上敬, 江面正幸, 上之原広司, 冨永悌二

脳血管内治療　5　(Suppl.)　21-21　2020年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
頸動脈ステント留置術後の過灌流に対するミノサイクリン塩酸塩を用いた周術期管理

坂田洋之, 江面正幸, 石田朋久, 阿部考貢, 井上敬, 遠藤英徳, 冨永悌二

脳血管内治療　5　(Suppl.)　45-45　2020年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
2D perfusion angiographyを用いた頸動脈ステント留置術後の過灌流予測

坂田洋之, 江面正幸, 石田朋久, 阿部考貢, 井上敬, 遠藤英徳, 遠藤俊毅, 上之原広司, 冨永悌二

脳循環代謝　32　(1)　74-74　2020年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
脳動脈瘤は無症候性脳梗塞発症のリスクファクター

井上敬, 遠藤英徳, 坂田洋之, 石田朋久, 江面正幸, 上之原広司, 冨永悌二

脳循環代謝　32　(1)　79-79　2020年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
Multiple Post-Labeling DelayによるASLを用いたCEA周術期脳循環動態評価

遠藤英徳, 藤村幹, 斉藤敦志, 遠藤俊毅, 大友一匡, 井上敬, 江面正幸, 上之原広司, 冨永悌二

脳循環代謝　32　(1)　104-104　2020年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
3D ASL法と123I-IMP SPECT併用による脳血流予備能評価と可能性について

大友一匡, 遠藤英徳, 杉山慎一郎, 藤村幹, 冨永悌二

脳循環代謝　32　(1)　106-106　2020年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
3D ASLとI-IMP SPECTによる脳血流予備能評価と可能性について

大友一匡, 遠藤英徳, 杉山慎一郎, 遠藤俊毅, 藤村幹

核医学　57　(Suppl.)　S163-S163　2020年10月
出版者・発行元： (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
【本音で語ろう、脳神経外科のリアルワールド-これからの生き方、学び方、働き方を考える】医局長クラスが語る、脳神経外科医の「働き方改革」(前編:Q&A編)

大宅宗一, 荒川芳輝, 榎本由貴子, 遠藤英徳, 菱川朋人, 安田宗義

脳神経外科速報　30　(4)　342-353　2020年4月
出版者・発行元： (株)メディカ出版
ISSN： 0917-1495
【本音で語ろう、脳神経外科のリアルワールド-これからの生き方、学び方、働き方を考える】より良く生き、学び、働くための処方箋 Subspecialtyを志すべきなのか?

遠藤英徳

脳神経外科速報　30　(4)　354-357　2020年4月
出版者・発行元： (株)メディカ出版
ISSN： 0917-1495
【本音で語ろう、脳神経外科のリアルワールド-これからの生き方、学び方、働き方を考える】医局長クラスが語る、脳神経外科医の「働き方改革」(前編:Q&A編)

大宅宗一, 荒川芳輝, 榎本由貴子, 遠藤英徳, 菱川朋人, 安田宗義

脳神経外科速報　30　(4)　342-353　2020年4月
出版者・発行元： (株)メディカ出版
ISSN： 0917-1495
基本をマスター脳神経外科手術のスタンダード内頸動脈瘤に対するhigh flow bypass

遠藤英徳, 藤村幹, 冨永悌二

脳神経外科速報　30　(3)　258-265　2020年3月
出版者・発行元： (株)メディカ出版
ISSN： 0917-1495
【脳動脈瘤】脳動脈瘤手術の今後の可能性

遠藤英徳, 佐藤健一, 杉山慎一郎, 藤村幹, 冨永悌二

脳神経外科ジャーナル　29　(2)　86-93　2020年2月
出版者・発行元：日本脳神経外科コングレス
ISSN： 0917-950X
健康長寿を達成するための明日への取り組み-脳血管内治療科の立場から-

江面正幸, 坂田洋之, 井上敬, 遠藤英徳, 上之原広司

日本臨床医療福祉学会プログラム・抄録集　18th　2020年
脳動脈瘤は無症候性脳梗塞発症のリスクファクター

井上敬, 遠藤英徳, 坂田洋之, 石田朋久, 江面正幸, 上之原広司, 冨永悌二

脳循環代謝(Web)　32　(1)　2020年

ISSN： 2188-7519
2D perfusion angiographyを用いた頚動脈ステント留置術後の過灌流予測

坂田洋之, 江面正幸, 石田朋久, 阿部考貢, 井上敬, 遠藤英徳, 遠藤俊毅, 上之原広司, 冨永悌二

脳循環代謝(Web)　32　(1)　2020年

ISSN： 2188-7519
2D perfusion angiographyを用いた頚動脈ステント留置術後の過灌流予測

坂田洋之, 江面正幸, 阿部考貢, 石田朋久, 井上敬, 遠藤英徳, 遠藤俊毅, 遠藤俊毅, 冨永悌二

脳血管内治療(Web)　5　(Supplement)　2020年

ISSN： 2424-1709
頚動脈ステント留置術後の過灌流に対するミノサイクリン塩酸塩を用いた周術期管理

坂田洋之, 江面正幸, 石田朋久, 阿部考貢, 井上敬, 遠藤英徳, 冨永悌二

脳血管内治療(Web)　5　(Supplement)　2020年

ISSN： 2424-1709
水流での剥離操作を用いて内視鏡下に摘出した橋前槽~第三脳室類上皮腫の2手術例

新妻邦泰, 新妻邦泰, 新妻邦泰, 石田朋久, 大沢伸一郎, 遠藤英徳, 冨永悌二

日本神経内視鏡学会プログラム・抄録集　27th　2020年
三叉神経根近傍の脳幹脳動静脈奇形に対する塞栓術の治療成績

遠藤英徳, 松本康史, 佐藤健一, 大沢伸一郎, 藤村幹, 新妻邦泰, 冨永悌二

脳血管内治療　4　(Suppl.)　S199-S199　2019年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
Computational fluid dynamicsを用いた内頸動脈海綿静脈洞部動脈瘤におけるフローダイバージョン治療の効果予測

中嶋伸太郎, 杉山慎一郎, 佐藤健一, 松本康史, 遠藤英徳, 伊藤明, 新妻邦泰, 冨永悌二, 大石英則

脳血管内治療　4　(Suppl.)　S230-S230　2019年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
Choroidal arteryを標的とした側脳室三角部髄膜腫の塞栓術

新妻邦泰, 遠藤英徳, 針生新也, 西嶌泰生, 冨永悌二

脳血管内治療　4　(Suppl.)　S239-S239　2019年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
内頸動脈海綿静脈洞瘻の瘻孔探索におけるスーパー正宗の有用性

森田隆弘, 新妻邦泰, 遠藤英徳, 冨永悌二

脳血管内治療　4　(Suppl.)　S316-S316　2019年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
血管芽腫の術前診断で摘出前栄養動脈塞栓術を施行した小脳上衣腫の1例

針生新也, 新妻邦泰, 遠藤英徳, 佐藤健一, 冨永悌二

脳血管内治療　4　(Suppl.)　S379-S379　2019年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
外科的血行再建と脳循環成人もやもや病に対するSTA-MCAバイパス術後急性期の脳循環動態と臨床像についての検討

藤村幹, 田代亮介, 亀山昌幸, 佐藤健一, 遠藤英徳, 新妻邦泰, 冨永悌二

脳循環代謝　31　(1)　87-87　2019年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
外科的血行再建と脳循環術中ICGによるCEA術後過灌流予測

井上敬, 坂田洋之, 井上智夫, 江面正幸, 上之原広司, 斉藤敦志, 藤村幹, 遠藤英徳, 新妻邦泰, 冨永悌二

脳循環代謝　31　(1)　88-88　2019年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
成人もやもや病に対するSTA-MCAバイパス術後の特異な脳循環動態 watershed shift現象の臨床像に関する検討

田代亮介, 藤村幹, 亀山昌幸, 麦倉俊司, 遠藤英徳, 新妻邦泰, 冨永悌二

脳循環代謝　31　(1)　112-112　2019年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
側副血行発達の異なる系統マウスにおける微小循環の検討

鹿毛淳史, 西嶌泰生, 藤村幹, 新妻邦泰, 遠藤英徳, Liu Jialing, 冨永悌二

脳循環代謝　31　(1)　120-120　2019年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
専門医に求められる最新の知識脳血管障害脳底動脈瘤に対するバイパスと血管内治療を併用したハイブリッド治療戦略

遠藤英徳, 佐藤健一, 藤村幹, 杉山慎一郎, 千葉朋浩, 冨永悌二

脳神経外科速報　29　(9)　960-966　2019年9月
出版者・発行元： (株)メディカ出版
ISSN： 0917-1495
術中ICGによるCEA術後過灌流予測

井上敬, 坂田洋之, 井上智夫, 江面正幸, 上之原広司, 斉藤敦志, 藤村幹, 遠藤英徳, 新妻邦泰, 冨永悌二

脳循環代謝(Web)　31　(1)　2019年

ISSN： 2188-7519
脳動脈瘤の出血源診断における造影MRIの有用性

面高俊介, 遠藤英徳, 新妻邦泰, 遠藤俊毅, 佐藤健一, 藤村幹, 松本康史, 井上敬, 冨永悌二

東北脳血管障害研究会学術集会記録集　40回　0076-0091　2018年12月
出版者・発行元：サノフィ(株)仙台オフィス
ISSN： 1880-9278
脳底動脈本幹部巨大動脈瘤に対する治療戦略

高橋佑介, 佐藤健一, 内田浩喜, 針生新也, 松本康史, 杉山慎一郎, 遠藤英徳, 冨永悌二

東北脳血管障害研究会学術集会記録集　40回　0161-0185　2018年12月
出版者・発行元：サノフィ(株)仙台オフィス
ISSN： 1880-9278
選択的後大脳動脈Wade testによる海馬機能評価

大沢伸一郎, 新妻邦泰, 鈴木匡子, 岩崎真樹, 佐藤健一, 遠藤英徳, 松本康史, 神一敬, 中里信和, 冨永悌二

脳血管内治療　3　(Suppl.)　S154-S154　2018年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
CEAとCASにおける術後脳循環動態の比較

大友一匡, 遠藤英徳

核医学　55　(Suppl.)　S205-S205　2018年11月
出版者・発行元： (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
バイオマーカーによる脳卒中診断

井上敬, 石田邦久, 新妻邦泰, 井上智夫, 齋藤敦志, 江面正幸, 遠藤英徳, 藤村幹, 冨永悌二

脳循環代謝　30　(1)　119-119　2018年10月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
カテコールアミン産生神経節細胞芽腫と脳動脈瘤を呈する成人患者に対する手術戦略 1症例報告(Surgical strategy for an adult patient with a catecholamine-producing ganglioneuroblastoma and a cerebral aneurysm: a case report)

Kumata Hiroyuki, Nishimura Ryuichi, Nakanishi Chikashi, Inoue Chihiro, Tezuka Yuta, Endo Hidenori, Miyagi Shigehito, Tominaga Teiji, Unno Michiaki, Kamei Takashi

Surgical Case Reports　4　(September)　1-6　2018年9月
出版者・発行元： Springer Berlin Heidelberg

詳細を見る詳細を閉じる

症例は73歳女性で、高血圧症のため降圧薬を処方されていたが、定期検診時の腹部超音波検査で右腎上極に最大径80mm程度の後腹膜腫瘍が検出されたため来院した。臨床検査では、血中アドレナリン値が0.12ng/mlで、カテコールアミンとその代謝物の24時間尿中排泄量はいずれも上昇していた。123I-MIBGシンチグラフィーで嚢胞壁にマーカーの異常集積を認めたため、褐色細胞腫と診断し、切除を予定した。しかし、術前に脳底動脈において直径8mmの脳動脈瘤が検出された。脳動脈瘤は治療が困難であったが、破裂のリスクは低く、高血圧症は動脈瘤破裂の重大な危険因子であることを考慮して、引き続き腫瘍切除を行うこととした。術中の脳動脈瘤破裂をモニタリングするために腰椎カテーテルを留置し、術中の神経機能を追跡するために経頭蓋運動誘発電位と体性感覚誘発電位を測定した。術中の血圧変動を慎重にモニタリングしながら腫瘍を切除し、術後の頭部CTで破裂の徴候がないことを確認した。病理組織学的に、本腫瘍はカテコールアミン産生神経節芽細胞腫と診断された。術後経過は良好で、血圧も改善した。
【Hybrid Neurosurgeonのための疾患別臨床脳血管解剖テキスト】(第2章)開頭手術と血管内治療の複合治療脳動脈瘤脳動脈瘤(バイパス併用)

遠藤英徳, 佐藤健一

脳神経外科速報　(2018増刊)　201-209　2018年9月
出版者・発行元： (株)メディカ出版
ISSN： 0917-1495
【Hybrid Neurosurgeonのための疾患別臨床脳血管解剖テキスト】(第2章)開頭手術と血管内治療の複合治療 dAVF 横静脈洞 S状静脈洞部dAVF

新妻邦泰, 遠藤英徳, 松本康史, 冨永悌二

脳神経外科速報　(2018増刊)　254-264　2018年9月
出版者・発行元： (株)メディカ出版
ISSN： 0917-1495
脳内出血急性期の血腫吸収過程に対する桂枝茯苓丸の効果および安全性 CT画像を用いた検討査読有り

大沢伸一郎, 遠藤英徳, 川村強, 冨永悌二

Neurological Surgery　46　(9)　763-770　2018年9月
出版者・発行元： (株)医学書院
ISSN： 0301-2603

eISSN： 1882-1251

詳細を見る詳細を閉じる

桂枝茯苓丸(KBG)は、東洋医学的な病態(証)である「お血」に対して有効とされ、脳内出血患者には本証(赤ら顔、肥満、高血圧など)を示す症例が多い。また、KBGは皮下血腫に対する吸収促進作用や組織血流改善作用などが報告されている。今回、脳内出血患者においてKBGは血腫吸収を促進するという仮説を立て、検証を行った。対象は、当院で2013年4月〜2016年6月に入院加療された脳内出血患者53例とし、KBG投与群(21例)と非投与群に分けて血腫吸収経過を群間比較した。KBG投与の適応基準は、「お血」と関連する「赤ら顔」「がっしりとした体格」「腹診による腹部充実」とした。血腫のCT値は、来院時にはKBG投与群が63.0±6.0(HU)、非投与群が61.5±1.9で有意差なく、1週間後はそれぞれ59.0±6.0、59.0±5.0で有意差は認められなかったが、2週間後はそれぞれ44.0±7.0、48.5±4.6でKBG投与群が有意に低値であった。代表例としてKBG投与群の1例を提示した。
【閉塞性血管障害病変の課題と展望】CEAとCASの適応と課題査読有り

遠藤英徳, 藤村幹, 松本康史, 遠藤俊毅, 佐藤健一, 新妻邦泰, 井上敬, 冨永悌二

脳神経外科ジャーナル　27　(7)　514-521　2018年7月
出版者・発行元：日本脳神経外科コングレス
ISSN： 0917-950X
小児もやもや病診断・治療の進歩と長期予後小児もやもや病に対する直接間接複合バイパス術長期治療成績と課題

藤村幹, 遠藤英徳, 新妻邦泰, 冨永悌二

The Mt. Fuji Workshop on CVD　36　1-4　2018年7月
出版者・発行元： (株)にゅーろん社
ISSN： 0289-8438
【早わかりポイントノートでかんたん学習くも膜下出血の看護】治療クリッピング術

遠藤英徳

Brain Nursing　34　(2)　120-122　2018年2月
出版者・発行元： (株)メディカ出版
ISSN： 0910-8459
選択的後大脳動脈Wada testによる海馬機能評価

大沢伸一郎, 新妻邦泰, 新妻邦泰, 鈴木匡子, 岩崎真樹, 佐藤健一, 遠藤英徳, 松本康史, 神一敬, 中里信和, 冨永悌二

脳血管内治療(Web)　3　(Supplement)　2018年

ISSN： 2424-1709
衝撃波の医療応用:最近の動向もふまえて

中川敦寛, 遠藤俊毅, 遠藤英徳, 大沢伸一郎, 冨永悌二, 中西史, 横沢友樹, 山下慎一, 飯久保正弘, 佐藤由加, 佐久間篤, 八木橋真央, 近野敦, 辻田哲平, 大谷清伸

衝撃波シンポジウム講演論文集(CD-ROM)　2017　2018年
パルスウォータージェットメスの開発:切開深達度均一化に関する検討

野口侑太, 中川敦寛, 楠哲也, 中西史, 横沢友樹, 山下慎一, 佐藤由加, 遠藤俊毅, 遠藤英徳, 新妻邦泰, 飯久保正弘, 冨永悌二

日本生体医工学会大会プログラム・抄録集(Web)　57th　2018年
ピエゾ駆動方式パルスウォータージェットメス開発:軟性内視鏡下の使用を想定したパルスジェット特性の検討

楠哲也, 中川敦寛, 野口侑太, 中西史, 横沢友樹, 山下慎一, 佐藤由加, 遠藤俊毅, 遠藤英徳, 新妻邦泰, 飯久保正弘, 冨永悌二

日本生体医工学会大会プログラム・抄録集(Web)　57th　2018年
両側中小脳脚に梗塞を発症した両側椎骨動脈閉塞2症例の検討

齋藤拓也, 遠藤薫, 安藤大祐, 福間一樹, 矢澤由加子, 板橋亮, 西嶌泰生, 遠藤英徳

臨床神経学(Web)　58　(1)　70(J‐STAGE)　2018年

ISSN： 1882-0654
脳血管障害の基礎知識脳卒中専門医に知っておいてほしいキーワード外科系(第13回) 頭蓋内内頸動脈系の動脈解離

遠藤英徳, 冨永悌二, 藤村幹, 松本康史

分子脳血管病　17　(1)　62-65　2018年1月
出版者・発行元： (株)先端医学社
ISSN： 1346-8995
何でもお悩み相談脳卒中Q&A これからの脳卒中医の理想のキャリアパスは?

遠藤英徳

脳神経外科速報　28　(1)　80-80　2018年1月
出版者・発行元： (株)メディカ出版
ISSN： 0917-1495
両側中小脳脚に梗塞を発症した両側椎骨動脈閉塞2症例の検討

齋藤拓也, 遠藤薫, 安藤大祐, 福間一樹, 矢澤由加子, 板橋亮, 西嶌泰生, 遠藤英徳

臨床神経学　58　(1)　70-70　2018年1月
出版者・発行元： (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
もやもや病を究めるもやもや病の脳循環研究 SPECTを用いた術後急性期病態の解明

藤村幹, 麦倉俊司, 遠藤英徳, 新妻邦泰, 藤原悟, 冨永悌二

脳循環代謝　29　(1)　144-144　2017年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
Multi-delay ASLによるCEA周術期脳循環動態評価

遠藤英徳, 藤村幹, 遠藤俊毅, 面高俊介, 大友一匡, 新妻邦泰, 冨永悌二

脳循環代謝　29　(1)　180-180　2017年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
頭蓋外内バイパス術後急性期に低灌流にもかかわらず症候性血管原性浮腫を生じた成人もやもや病の1例

田代亮介, 藤村幹, 麦倉俊司, 新妻邦泰, 遠藤英徳, 冨永悌二

脳循環代謝　29　(1)　193-193　2017年11月
出版者・発行元： (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
Choroidal arteryを標的としたAVM塞栓術の治療成績

遠藤英徳, 松本康史, 佐藤健一, 新妻邦泰, 遠藤俊毅, 藤村幹, 冨永悌二

脳血管内治療　2　(Suppl.)　S32-S32　2017年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
仙骨部脊髄動静脈シャント疾患に対する外科治療

遠藤俊毅, 佐藤健一, 藤村幹, 面高俊介, 遠藤英徳, 松本康史, 冨永悌二

脳血管内治療　2　(Suppl.)　S110-S110　2017年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
治療困難な脳動脈瘤に対するバイパス術併用血管内治療

佐藤健一, 藤村幹, 遠藤英徳, 松本康史, 冨永悌二

脳血管内治療　2　(Suppl.)　S121-S121　2017年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
エンボスフィアを用いたTAEで根治し得た海綿静脈洞部硬膜動静脈瘻の一治療例

新妻邦泰, 坂田洋之, 大沢伸一郎, 遠藤英徳, 松本康史, 冨永悌二

脳血管内治療　2　(Suppl.)　S204-S204　2017年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
造影MRIを用いた多発脳動脈瘤の出血源診断

面高俊介, 遠藤英徳, 新妻邦泰, 遠藤俊毅, 藤村幹, 佐藤健一, 松本康史, 冨永悌二

脳血管内治療　2　(Suppl.)　S269-S269　2017年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
頭部CT Angiographyで中硬膜動脈は描出評価できるのか?

田中良隆, 茅野伸吾, 渡部紗織, 羽鳥伸哉, 遠藤英徳, 明石敏昭

脳血管内治療　2　(Suppl.)　S359-S359　2017年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
専門医に求められる最新の知識脊椎脊髄脊髄動静脈奇形に対する治療戦略

遠藤俊毅, 佐藤健一, 遠藤英徳, 松本康史, 冨永悌二

脳神経外科速報　27　(8)　836-840　2017年8月
出版者・発行元： (株)メディカ出版
ISSN： 0917-1495
脳動脈瘤治療の標準化と最適化脳動脈瘤塞栓術の標準化と最適化

松本康史, 佐藤健一, 遠藤俊毅, 遠藤英徳, 藤村幹, 冨永悌二

The Mt. Fuji Workshop on CVD　35　72-77　2017年7月
出版者・発行元： (株)にゅーろん社
ISSN： 0289-8438
【脳血管障害診療のエッセンス】脳梗塞の再発予防外科療法頸動脈内膜剥離術とステント留置術

遠藤英徳, 冨永悌二

日本医師会雑誌　146　(特別1)　S278-S280　2017年6月
出版者・発行元： (公社)日本医師会
ISSN： 0021-4493
10分で速習! スライドでわかる脳神経外科手術のポイント VA-PICA ANに対する手術のコツとピットフォール

遠藤英徳, 藤村幹, 遠藤俊毅, 冨永悌二

脳神経外科速報　27　(3)　265-272　2017年3月
出版者・発行元： (株)メディカ出版
ISSN： 0917-1495
【出血性脳血管障害】出血発症もやもや病の治療戦略

藤村幹, 遠藤英徳, 新妻邦泰, 冨永悌二

脳神経外科ジャーナル　26　(2)　112-116　2017年2月
出版者・発行元：日本脳神経外科コングレス
ISSN： 0917-950X
もやもや病に対する直接間接複合血行再建術:頭蓋形成における生体性吸収性プレート併用法の長期成績

藤村幹, 遠藤英徳, 新妻邦泰, 坂田洋之, 冨永悌二

日本整容脳神経外科研究会プログラム・抄録集　10th　2017年
エンボスフィアを用いたTAEで根治し得た海綿静脈洞部硬膜動静脈瘻の一治療例

新妻邦泰, 坂田洋之, 大沢伸一郎, 遠藤英徳, 松本康史, 冨永悌二

脳血管内治療(Web)　2　(Supplement)　2017年

ISSN： 2424-1709
内頚動脈前壁チマメ状動脈瘤の病態と治療戦略

遠藤英徳, 藤村幹, 清水宏明, 遠藤俊毅, 藤原悟, 冨永悌二

日本臨床脳神経外科学会プログラム・抄録集　20th　2017年
下垂体腺腫治療後の内頸動脈瘤形成その成因と治療

坂田洋之, 遠藤英徳, 藤村幹, 小川欣一, 城倉英史, 川岸潤, 佐藤健一, 松本康史, 遠藤俊毅, 冨永悌二

東北脳血管障害研究会学術集会記録集　38回　0271-0283　2016年12月
出版者・発行元：サノフィ(株)仙台オフィス
ISSN： 1880-9278
【どうする?抗血栓薬中止・変更・橋渡し】パターンで覚える!中止、変更のタイミングくも膜下出血

遠藤英徳

Brain Nursing　32　(11)　1149-1150　2016年11月
出版者・発行元： (株)メディカ出版
ISSN： 0910-8459
脳卒中の最新治療

遠藤英徳

宮城県医師会報　(850)　893-897　2016年11月
出版者・発行元： (公社)宮城県医師会
脳動脈瘤における血液滞留時間と動脈硬化性変化との関係

杉山慎一郎, 遠藤英徳, 新妻邦泰, 冨永悌二

脳循環代謝　28　(1)　165-165　2016年11月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
成人もやもや病に対する直接間接複合バイパス術脳循環画像に基づいた周術期管理の効果とpitfall

藤村幹, 坂田洋之, 新妻邦泰, 遠藤英徳, 井上敬, 冨永悌二

脳循環代謝　28　(1)　182-182　2016年11月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
Arterial Spin Labelingを使用したCEA周術期脳循環動態評価

遠藤英徳, 藤村幹, 遠藤俊毅, 井上敬, 清水宏明, 冨永悌二

脳循環代謝　28　(1)　208-208　2016年11月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
後方循環血行力学的脳虚血に対して血行再建を行った2例

長田佳整, 遠藤英徳, 遠藤俊毅, 佐藤健一, 松本康史, 藤村幹, 冨永悌二

脳循環代謝　28　(1)　216-216　2016年11月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
CEA術前脳循環予備能測定は必要か?

井上敬, 江面正幸, 上之原広司, 遠藤英徳, 藤村幹, 冨永悌二

脳循環代謝　28　(1)　218-218　2016年11月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
Choroidal arteryを標的としたAVM塞栓術の治療成績

遠藤英徳, 松本康史, 佐藤健一, 近藤竜史, 新妻邦泰, 遠藤俊毅, 藤村幹, 冨永悌二

脳血管内治療　1　(Suppl.)　S98-S98　2016年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
腰椎硬膜動静脈瘻の特徴胸椎病変との違いについて

遠藤俊毅, 遠藤英徳, 佐藤健一, 面高俊介, 松本康史, 冨永悌二

脳血管内治療　1　(Suppl.)　S130-S130　2016年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
コイル塞栓術後再開通により破裂した脳動脈瘤に関する数値流体力学的解析

園部真也, 杉山慎一郎, 松本康史, 遠藤英徳, 新妻邦泰, 冨永悌二

脳血管内治療　1　(Suppl.)　S248-S248　2016年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
OUTCOME AND RISK FACTORS FOR MENINGITIS AFTER CRANIOTOMY IN PATIENTS WITH SUBARACHNOID HEMORRHAGE

T. Inoue, M. Fujimura, H. Endo, T. Tominaga

INTERNATIONAL JOURNAL OF STROKE　11　(SUPP 3)　66-66　2016年10月

ISSN： 1747-4930

eISSN： 1747-4949
中枢神経機能の計測と調整(第1回) 拡散テンソル画像・拡散テンソルトラクトグラフィーの理学療法領域における臨床応用

阿部浩明, 遠藤英徳, 千葉朋浩, 長嶺義秀, 神将文, 藤原悟

理学療法学　43　(4)　349-357　2016年8月
出版者・発行元： (公社)日本理学療法士協会
ISSN： 0289-3770

eISSN： 2189-602X
脳主幹動脈閉塞に対する緊急EC-IC bypassの治療成績

遠藤英徳, 藤村幹, 清水宏明, 井上敬, 藤原悟, 冨永悌二

The Mt. Fuji Workshop on CVD　34　196-200　2016年8月
出版者・発行元： (株)にゅーろん社
ISSN： 0289-8438

詳細を見る詳細を閉じる

脳主幹動脈閉塞に対する緊急extracranial-intracranial(EC-IC) bypassの治療成績について検討した。前方循環の脳主幹動脈閉塞に対して緊急EC-IC bypass術を施行した11例を対象とした。閉塞部位は内頸動脈が7例、中大脳動脈(M1)が4例で、閉塞機転の原因は、動脈硬化7例、動脈解離3例、放射線治療後1例であった。症状出現から手術開始までの時間は6.5〜96時間であった。Single bypassを9例、double bypassを2例に行い、M4の遮断時間は18〜54分であった。Modified NIHSSは9例で術後改善し、中央値の推移は術直前6、術翌日5、術後7日目3であった。術後7日目のmodified NIHSSは術直前と比較して有意に改善した。腎不全に起因する全身状態悪化をきたした1例で梗塞増大による症状悪化を認めた。6ヵ月後に画像追跡を行った9例全例でbypassの開存を確認した。6ヵ月後の転帰は、良好(mRS 0-2)が8例(73%)であった。
QUANTITATIVE MEASUREMENT OF CEREBRAL BLOOD FLOW USING SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY WITH VENOUS BLOOD SAMPLING

T. Inoue, H. Shimizu, M. Fujimura, K. Sato, H. Endo, K. Niizuma, H. Sakata, T. Tominaga

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　36　402-402　2016年6月

ISSN： 0271-678X

eISSN： 1559-7016
Filum terminale AVMの1例

梶谷卓未, 遠藤俊毅, 坂田洋之, 佐藤健一, 松本康史, 遠藤英徳, 冨永悌二

日本脊髄外科学会プログラム・抄録集　31st　2016年
もやもや病に対する直接間接複合血行再建術:皮切・頭蓋形成の工夫による非神経学的合併症回避の試み

藤村幹, 遠藤英徳, 新妻邦泰, 坂田洋之, 冨永悌二

日本整容脳神経外科研究会プログラム・抄録集　9th　2016年
もやもや病に対する直接間接複合血行再建術:皮膚切開・頭蓋形成の工夫による非神経学的合併症回避の試み

藤村幹, 遠藤英徳, 新妻邦泰, 坂田洋之, 冨永悌二

日本整容脳神経外科研究会研究会記録集　9th　2016年
成人もやもや病に対する直接間接複合バイパス術:脳循環画像に基づいた周術期管理の効果とpitfall

藤村幹, 坂田洋之, 新妻邦泰, 遠藤英徳, 井上敬, 冨永悌二

脳循環代謝(Web)　28　(1)　2016年

ISSN： 2188-7519
Arterial Spin Labelingを使用したCEA周術期脳循環動態評価

遠藤英徳, 藤村幹, 遠藤俊毅, 井上敬, 清水宏明, 冨永悌二

脳循環代謝(Web)　28　(1)　2016年

ISSN： 2188-7519
A case of ruptured infectious anterior cerebral artery aneurysm treated by interposition graft bypass using the superficial temporal artery

Takatsugu Abe, Hidenori Endo, Hiroaki Shimizu, Miki Fujimura, Toshiki Endo, Hiroyuki Sakata, Mika Watanabe, Teiji Tominaga

Surgical Neurology International　7　(1)　2016年1月1日
出版者・発行元： Medknow Publications
DOI： 10.4103/2152-7806.173319 　

ISSN： 2152-7806

eISSN： 2152-7806
三叉神経根近傍の脳幹脳動静脈奇形臨床的特徴と治療成績

遠藤英徳, 佐藤健一, 大沢伸一郎, 松本康史, 藤村幹, 藤原悟, 冨永悌二

東北脳血管障害研究会学術集会記録集　37回　248-266　2015年12月
出版者・発行元：サノフィ(株)仙台オフィス
ISSN： 1880-9278
急性脳底動脈解離の臨床像

佐藤健一, 遠藤英徳, 板橋亮, 松本康史, 冨永悌二

東北脳血管障害研究会学術集会記録集　37回　316-342　2015年12月
出版者・発行元：サノフィ(株)仙台オフィス
ISSN： 1880-9278
脳動脈瘤ステント併用塞栓術の中期成績ステント支援瘤内塞栓術における遠隔期虚血性脳血管障害

近藤竜史, 隈部俊宏, 松本康史, 佐藤健一, 遠藤英徳, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　9　(6)　S190-S190　2015年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072

eISSN： 2186-2494
ONYXはAVMの治療成績を向上させたか? 脳動静脈奇形に対する集学的治療における血管内治療

新妻邦泰, 佐藤健一, 松本康史, 遠藤英徳, 藤村幹, 近藤竜史, 川岸潤, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　9　(6)　S191-S191　2015年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072

eISSN： 2186-2494
脳動静脈奇形に対する集学的治療における血管内治療

佐藤健一, 松本康史, 遠藤英徳, 藤村幹, 近藤竜史, 川岸潤, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　9　(6)　228-228　2015年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072

eISSN： 2186-2494
看護師の文武両道患者管理と医師協働当院ICUにおける、くも膜下出血初期診療時の看護師・医師協働

森智弘, 梅田康弘, 佐藤恵子, 津田泰子, 眞野唯, 井上泰豪, 佐藤健一, 杉山慎一郎, 遠藤英徳, 松本康史

JNET: Journal of Neuroendovascular Therapy　9　(6)　S451-S451　2015年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072

eISSN： 2186-2494
頸動脈血行再建術後の脳循環動態の評価における3D ASLの有用性の検討 SPECTとの比較

大友一匡, 遠藤英徳, 石倉和彦, 児玉修一, 佐藤直, 藤原悟

臨床放射線　60　(12)　1585-1596　2015年11月
出版者・発行元：金原出版(株)
ISSN： 0009-9252
小児もやもや病に対する直接間接複合バイパス術長期治療成績の検討

藤村幹, ラシャド・シェリフ, 遠藤英徳, 新妻邦泰, 坂田洋之, 佐藤健一, 冨永悌二

脳循環代謝　27　(1)　139-139　2015年10月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
破裂内頸動脈瘤に対するEC-IC bypassの治療成績

遠藤英徳, 藤村幹, 清水宏明, 井上敬, 佐藤健一, 藤原悟, 冨永悌二

脳循環代謝　27　(1)　142-142　2015年10月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
CEA術後過灌流予測における脳循環予備能測定の意義

井上敬, 江面正幸, 上之原広司, 遠藤英徳, 藤村幹, 藤原悟, 富永悌二

脳循環代謝　27　(1)　152-152　2015年10月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
深部脳動静脈奇形周囲にcerebral proliferative angiopathyの2次的形成を認めた小児例

坂田洋之, 藤村幹, 佐藤健一, 新妻邦泰, 遠藤英徳, 冨永悌二

脳循環代謝　27　(1)　190-190　2015年10月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
クモ膜下出血後急性期脳血流の時間的・空間的変化と臨床転帰との相関についての検討

佐藤健一, 遠藤英徳, 藤村幹, 井上敬, 清水宏明, 冨永悌二

脳循環代謝　27　(1)　190-190　2015年10月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
【ブレインくんからの挑戦状!ドレーン管理正解はどっち?】開放式ドレナージについて理解しよう

遠藤英徳

Brain Nursing　31　(7)　642-649　2015年7月
出版者・発行元： (株)メディカ出版
ISSN： 0910-8459
【脳卒中における脳循環代謝画像のすべて-初心者からエキスパートまで-】脳卒中の各病態における脳循環代謝画像の意義くも膜下出血後脳血流の時間的・空間的変化 3-D SRT softwareを用いたSPECT解析

佐藤健一, 清水宏明, 井上敬, 藤村幹, 遠藤英徳, 冨永悌二

The Mt. Fuji Workshop on CVD　33　98,108-102,108　2015年7月
出版者・発行元： (株)にゅーろん社
ISSN： 0289-8438

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脳動脈瘤破裂によるくも膜下出血(SAH)後、遅発性脳虚血(DCI)予防治療中の88例(男27例、女61例、平均年齢61.2歳)を対象に、SPECT検査を急性期に2回施行し3次元SRTソフトウェアを用いて脳血流量を評価し、局所脳血流量の変化と対応領域の脳梗塞出現の有無および臨床転帰について後方視的に検討した。88症例の脳全体1936領域中40領域でDCIによる脳梗塞巣を認めた。各領域のradio-signal countを両側小脳半球のradio-signal countの平均で除したrCBF比が、正常ボランティア10例の平均と比較して1回目も2回目もhypoperfusion(90%未満)であった領域の13.0%、1回目がnormoperfusion(90%〜110%未満)で2回目がhypoperfusionであった領域の19.1%に脳梗塞巣を認めた。またSAH急性期治療中にrCBFが増加する領域と減少する領域が混在する42例ではそれ以外の群と比較して3ヵ月後の臨床転帰が有意に不良で、転帰不良の原因の50%はDCIによるものであった。
開頭術または血管内塞栓術後の残存・再発脳動脈瘤に対する開頭術査読有り

清水宏明, 柳澤俊晴, 遠藤英徳, 井上敬, 藤村幹, 松本康史, 冨永悌二

脳卒中の外科　43　(3)　212-217　2015年5月
出版者・発行元： (一社)日本脳卒中の外科学会
ISSN： 0914-5508

eISSN： 1880-4683

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2001年以降に開頭術またはコイル塞栓術を施行し、術後に動脈瘤の残存、再発または破裂を呈して開頭術を施行した14名(男3、女11、平均年齢58歳)を対象に、臨床症状や再手術の成績について再調査した。初回発症形式は、くも膜下出血8名、未破裂動脈瘤6名で、開頭術を8名(クリッピング術7、ラッピング術1)、コイル塞栓術を6名に施行した。再手術前の症状は、破裂1名、動脈瘤頸部残存2名、動脈瘤の増大11名であった。どちらの術式でも、初回手術で不完全閉塞の場合に再発リスクが上昇し、コイル塞栓術の場合は10mm以上の大きさも再発リスクになることが示された。
臨床実習に向けての学内教育の取り組み事前実習プログラム・個別的特徴の把握

遠藤浩之, 渡邊雅行, 山田英徳, 村岡健史

常葉大学保健医療学部紀要　6　(1)　45-52　2015年3月
出版者・発行元：常葉大学
ISSN： 2188-2800
1型糖尿病に合併した成人・類もやもや病の1手術例

赤松洋祐, 藤村幹, 坂田洋之, 遠藤英徳, 板橋亮, 冨永悌二

Neurological Surgery　43　(3)　227-233　2015年3月
出版者・発行元： (株)医学書院
ISSN： 0301-2603

eISSN： 1882-1251

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32歳女。6歳時に1型糖尿病を発症しインスリン自己注射を行っていた。右眼前暗黒感で受診し、MRIで頭蓋内虚血性病変を指摘された。123I-IMP SPECTでは、左前頭葉・頭頂葉において左前頭葉の梗塞巣周囲に広がる安静時血流低下を認めた。左大脳半球に直接・間接血行再建術を施行した。周術期の血糖コントロールは持続皮下インスリン注入療法にボーラスインスリン療法を併用した。過灌流症候群の予防を目的として、術直後より予防的降圧とミノサイクリン塩酸塩投与を開始した。術翌日、7日目のSPECT上も明らかな過灌流はみられなかった。術後MRAでは良好なSTAの開通性を確認し、拡散強調像でも新たな虚血性病変はなく、術後2週間で神経学的欠損症状もなく自宅退院した。術後3ヵ月間、脳血管イベントはなく経過している。
もやもや病に対する血行再建術後過灌流に対するミノサイクリンを用いた周術期管理の現状と問題点査読有り

藤村幹, 新妻邦泰, 遠藤英徳, 佐藤健一, 井上敬, 冨永悌二

脳卒中の外科　43　(2)　136-140　2015年3月
出版者・発行元： (一社)日本脳卒中の外科学会
ISSN： 0914-5508

eISSN： 1880-4683

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もやもや病に対して直接血行再建術を行い、脳保護作用を持つミノサイクリン塩酸塩を用いて周術期管理を行った連続75例89手術の治療成績、周術期合併症の頻度を検証した。全例、浅側頭動脈-中大脳動脈吻合術を施行し、過灌流予防を目的とした血圧管理とミノサイクリン塩酸塩投与を行った結果、過灌流による血圧依存性に変動する出血を伴わない局所神経脱落症状を認めた症例はなかった。しかし、無症候性ではあったものの過灌流による遅発性頭蓋内出血を6例6側に認め、高年齢と男性が遅発性頭蓋内出血の正の関連因子であることが示唆された。
【脳動脈瘤と脳動静脈奇形の最新治療】開頭・血管内手術を利用した複合脳動脈瘤手術査読有り

清水宏明, 松本康史, 遠藤英徳, 井上敬, 藤村幹, 冨永悌二

脳神経外科ジャーナル　24　(3)　165-172　2015年3月
出版者・発行元：日本脳神経外科コングレス
ISSN： 0917-950X
クモ膜下出血後脳血流の時間的・空間的変化 3DSRT softwareを用いたSPECT解析

佐藤健一, 清水宏明, 井上敬, 藤村幹, 遠藤英徳, 冨永悌二

脳血管攣縮　30　56-56　2015年3月
出版者・発行元：スパズム・シンポジウム事務局
ISSN： 0912-7070
AVM塞栓術の適応と方法 OnyxとNBCAの使い分け AVM塞栓術の治療戦略 OnyxとNBCAの使い分け

松本康史, 佐藤健一, 坂田洋之, 遠藤英徳, 藤原悟, 高橋明, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　8　(6)　179-179　2014年12月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072

eISSN： 2186-2494
バルーン閉塞試験その判定方法とバイパス術の適応内頸動脈遮断時の脳血液循環時間と脳血流量との関係について

佐藤健一, 松本康史, 遠藤英徳, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　8　(6)　183-183　2014年12月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072

eISSN： 2186-2494
出血発症した三叉神経根近傍の脳幹部動静脈奇形4例の治療経験

大沢伸一郎, 遠藤英徳, 佐藤健一, 松本康史, 藤村幹, 藤原悟, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　8　(6)　368-368　2014年12月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072

eISSN： 2186-2494
Laser speckle flowgraphyを用いてバイパス術前後の眼循環評価を行った内頸動脈閉塞症の一例

面高俊介, 遠藤英徳, 藤村幹, 清水宏明, 藤原悟, 冨永悌二

東北脳血管障害研究会学術集会記録集　36回　138-150　2014年12月
出版者・発行元：サノフィ(株)仙台オフィス
ISSN： 1880-9278
動脈硬化性変化をきたした未破裂脳動脈瘤5例の検討

杉山慎一郎, 遠藤英徳, 新妻邦泰, 清水宏明, 長嶺義秀, 藤原悟, 冨永悌二

東北脳血管障害研究会学術集会記録集　36回　186-204　2014年12月
出版者・発行元：サノフィ(株)仙台オフィス
ISSN： 1880-9278
非出血性脳動脈解離の外科治療

遠藤英徳, 清水宏明, 鈴木一郎, 近藤竜史, 松本康史, 藤村幹, 井上敬, 佐藤健一, 藤原悟, 冨永悌二

東北脳血管障害研究会学術集会記録集　36回　290-314　2014年12月
出版者・発行元：サノフィ(株)仙台オフィス
ISSN： 1880-9278
破裂瘤の治療後早期に破裂した前交通動脈瘤の一例血行力学的変化の検討

新妻邦泰, 杉山慎一郎, 遠藤英徳, 佐藤健一, 松本康史, 藤村幹, 冨永悌二

脳循環代謝　26　(1)　166-166　2014年11月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
破裂内頸動脈瘤に対するEC-IC bypass術後急性期の脳循環動態

遠藤英徳, 藤村幹, 佐藤健一, 清水宏明, 藤原悟, 冨永悌二

脳循環代謝　26　(1)　176-176　2014年11月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
CEA術前後にSPECTは必須か?

井上敬, 藤村幹, 佐藤健一, 遠藤英徳, 新妻邦泰, 坂田洋之, 江面正幸, 上之原広司, 藤原悟, 冨永悌二

脳循環代謝　26　(1)　200-200　2014年11月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
A Case of Anterior Communicating Artery Aneurysm Ruptured after the Treatment of Another Ruptured Aneurysm

Kuniyasu Niizuma, Shin-ichiro Sugiyama, Hidenori Endo, Kenichi Sato, Yasushi Matsumoto, Miki Fujimura, Teiji Tominaga

CEREBROVASCULAR DISEASES　38　46-47　2014年9月

ISSN： 1015-9770

eISSN： 1421-9786
【脳動脈瘤の最新知識-成因・病態から最先端治療まで-】Clippingとparent artery occlusion/flow alterationの使い分けを要する内頸動脈瘤の治療査読有り

清水宏明, 遠藤英徳, 井上敬, 藤村幹, 松本康史, 冨永悌二

脳神経外科ジャーナル　23　(9)　721-728　2014年9月
出版者・発行元：日本脳神経外科コングレス
ISSN： 0917-950X
ピエゾ方式パルスウォータージェットメス：有用性と安全性

中川敦寛, 冨永悌二, 遠藤俊毅, 園田順彦, 斉藤竜太, 岩崎真樹, 藤村幹, 遠藤英徳, 小川欣一, 川口奉洋

生体医工学　52　(0)　63-O-64　2014年8月17日
出版者・発行元：公益社団法人日本生体医工学会
DOI： 10.11239/jsmbe.52.O-63 　

ISSN： 1347-443X 1881-4379
【最新臨床脳卒中学[上]-最新の診断と治療-】最新の治療動向:概論脳卒中慢性期の外科治療

遠藤英徳, 冨永悌二

日本臨床　72　(増刊5 最新臨床脳卒中学(上))　714-720　2014年7月
出版者・発行元： (株)日本臨床社
ISSN： 0047-1852
【脳動静脈奇形に対する集学的治療】AVMに対する集学的治療 AVMに対する治療戦略血管内治療医の立場から

松本康史, 近藤竜史, 新妻邦泰, 遠藤英徳, 藤原悟, 高橋明, 冨永悌二

The Mt. Fuji Workshop on CVD　32　50-53　2014年7月
出版者・発行元： (株)にゅーろん社
ISSN： 0289-8438
くも膜下出血急性期脳損傷のメカニズム

遠藤英徳, 冨永悌二

脳循環代謝　25　(2)　81-84　2014年7月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
日本における作業療法士国家試験合格者の推移国家試験受験者の減少と合格率の低迷

遠藤浩之, 小野弘, 山田英徳, 村岡健史, 澤俊二

日本作業療法学会抄録集　48回　PED-29　2014年6月
出版者・発行元： (一社)日本作業療法士協会
ISSN： 1880-6635
脳血管内治療における数値流体力学 CFD(Computational Fluid Dynamics)の最前線脳動脈瘤壁の硬化性変化

新妻邦泰, 杉山慎一郎, 遠藤英徳, 松本康史, 冨永悌二

脳神経外科速報　24　(6)　640-643　2014年6月
出版者・発行元： (株)メディカ出版
ISSN： 0917-1495
第三脳室開窓術後にSIADHによる低ナトリウム血症を呈した1例査読有り

重枝諒太, 遠藤英徳, 藤村幹, 小川欣一, 清水宏明, 冨永悌二

Neurological Surgery　42　(4)　335-339　2014年4月
出版者・発行元： (株)医学書院
ISSN： 0301-2603

eISSN： 1882-1251

詳細を見る詳細を閉じる

症例は25歳男性で、意識障害、歩行障害を主訴に当院入院となった。入院時、臨床経過および頭部MRI所見より、Shunt不全による水頭症再発と診断し、内視鏡的第三脳室開窓術を施行した。術後、意識レベルは改善し、独歩可能となったが、術後6日目より再び意識レベルの悪化、独歩不可能となり、血液検査所見、体重の推移から、SIADHによる低ナトリウム血症と診断した。水制限を開始したところ、意識レベルは改善し、独歩可能な状態となった。水制限は3日間で終了したが、術後10日目に血清Naは改善し、術後24日目に自宅退院となった。
経過観察中に増大した80歳以上の未破裂脳動脈瘤に対する瘤内塞栓術高齢者における塞栓術の注意点、工夫

鈴木一郎, 松本康史, 新妻邦泰, 近藤竜史, 遠藤英徳, 藤原悟, 高橋明, 清水宏明, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　8　(1)　14-20　2014年3月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072

eISSN： 2186-2494
【CT、MRI…ではこう写る超簡単!疾患別画像のみかた】くも膜下出血の画像

遠藤英徳

Brain Nursing　30　(2)　128-129　2014年2月
出版者・発行元： (株)メディカ出版
ISSN： 0910-8459
当施設における症候性脳血管攣縮当院でのくも膜下出血治療方針の転換および開頭術転帰不良因子の検討

井上敬, 清水宏明, 藤村幹, 遠藤英徳, 冨永悌二

脳血管攣縮　29　1-3　2014年2月
出版者・発行元：スパズム・シンポジウム事務局
ISSN： 0912-7070

詳細を見る詳細を閉じる

2003年〜2012年に破裂動脈瘤によるクモ膜下出血に対し、発症72時間以内に開頭クリッピング術またはコイル塞栓術を施行した1066例の成績を報告した。内訳はクリッピング術575例、塞栓術491例で、2007年以降はコイル塞栓術を第一選択とする方針に変更しており、クリッピング術の占める割合は変更前67%、変更後44%であった。転帰良好例(mRS 0〜2)が占める割合は2007年以前71%、以降76%であった。2007年以降の開頭クリッピング術において、転帰良好例は87%であった。症候性脳血管攣縮を来たした症例は22.3%で、永続的神経脱落症状は8.1%に認めた。髄膜炎は9.5%に発症した。入院時WFNS重症例および髄膜炎の発症が転帰不良と関係しており、脳血管攣縮の発症そのものは関連がなかった。
Fusion imageを用いた前脈絡叢動脈の解剖学的variationの術前評価

青木靖子, 遠藤英徳, 新妻邦泰, 井上敬, 清水宏明, 冨永悌二

Neurological Surgery　41　(12)　1075-1080　2013年12月
出版者・発行元： (株)医学書院
ISSN： 0301-2603

詳細を見る詳細を閉じる

前脈絡叢動脈(AchoA)の解剖学的variationの術前評価に血管撮影とMRIのfusion画像が有用であった未破裂脳動脈瘤2例を経験した。症例1は56歳男で、未破裂左内頸脳動脈瘤の治療目的で受診した。AchoAは左内頸動脈(ICA)から分岐し、choroidal fissureに向かう分岐を出した後にP2-P3移行部に合流し、PCA領域の灌流に関与していることが示され、過形成型のAchoAと診断した。左AchoA起始部は動脈瘤体部に存在していたため、AchoA起始部を形成するようにクリッピングを施行した。術後経過は良好で自宅退院となった。症例2は58歳女で、未破裂右内頸脳動脈瘤の治療目的で受診した。動脈は右PcomAから右AchoAが分岐し、さらに右PcomAのICAからの起始部が退縮しているvariationと考えられた。コイル塞栓術を施行し、術後経過は良好で自宅退院となった。
術中の判断によりクリッピング術から塞栓術に変更した脳動脈瘤症例の検討

鈴木一郎, 松本康史, 清水宏明, 菊池登志雄, 近藤竜史, 遠藤英徳, 井上敬, 藤原悟, 高橋明, 冨永悌二

東北脳血管障害研究会学術集会記録集　35回　215-247　2013年12月
出版者・発行元：サノフィ(株)仙台オフィス
ISSN： 1880-9278
外科治療と循環代謝もやもや病に対する頭蓋外内血行再建術前後の吻合部局所CBF変化と過灌流症候群の関連についての検討

藤村幹, 新妻邦泰, 遠藤英徳, 井上敬, 清水宏明, 冨永悌二

脳循環代謝　25　(1)　114-114　2013年11月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401
内頸動脈遮断時の脳血液循環時間と脳血流量の関係について

佐藤健一, 清水宏明, 井上敬, 藤村幹, 遠藤英徳, 冨永悌二

脳循環代謝　25　(1)　128-128　2013年11月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401
各種バイパス術における術後急性期の脳循環手術侵襲による影響との鑑別を含めて

清水宏明, 遠藤英徳, 藤村幹, 井上敬, 佐藤健一, 冨永悌二

脳循環代謝　25　(1)　156-156　2013年11月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401
脳動脈瘤塞栓術困難な動脈瘤への挑戦ステント支援瘤内塞栓術の効果と限界中期転帰に見るワイドネック動脈瘤治療の現状

近藤竜史, 松本康史, 鈴木一郎, 新妻邦泰, 遠藤英徳, 藤原悟, 高橋明, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　7　(6)　143-143　2013年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072
内頸動脈遮断時の脳血液循環時間と脳血流量の関係

佐藤健一, 清水宏明, 藤村幹, 井上敬, 松本康史, 遠藤英徳, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　7　(6)　178-178　2013年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072
出血性椎骨動脈解離に対するinternal coil trappingにおける穿通枝温存

遠藤英徳, 松本康史, 近藤竜史, 鈴木一郎, 新妻邦泰, 佐藤健一, 清水宏明, 高橋明, 藤原悟, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　7　(6)　207-207　2013年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072
破裂瘤の治療後早期に破裂した前交通動脈瘤の1例血行力学的変化の検討

新妻邦泰, 杉山慎一郎, 遠藤英徳, 鈴木一郎, 近藤竜史, 松本康史, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　7　(6)　266-266　2013年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072

eISSN： 2186-2494
Entryのみが閉塞して盲端となった巨大な偽腔が塞栓源と考えられた頸動脈解離に対するステント留置術

河田幸波, 松本康史, 近藤竜史, 鈴木一郎, 新妻邦泰, 遠藤英徳, 藤原悟, 高橋明, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　7　(6)　357-357　2013年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072

eISSN： 2186-2494
増大する脳動脈瘤の血行動態解析

杉山慎一郎, 清水宏明, 遠藤英徳, 新妻邦泰, 近藤竜史, 松本康史, 長嶺義秀, 藤原悟, 冨永悌二

日本脳ドック学会総会プログラム・抄録集　22nd　2013年
CFD解析による脳動脈瘤壁性状の予測

新妻邦泰, 杉山慎一郎, 遠藤英徳, 清水宏明, 近藤竜史, 松本康史, 長嶺義秀, 藤原悟, 冨永悌二

日本脳ドック学会総会プログラム・抄録集　22nd　2013年
前頭側頭開頭における骨欠損部に対する改良型キーホールプレートの使用経験

井上敬, 清水宏明, 遠藤英徳, 藤原悟, 冨永悌二

日本整容脳神経外科研究会研究会記録集　6th　2013年
脳神経血管内治療医に必要な知識脳動脈瘤に対する血管内手術の基本手技 simple techniqueによる瘤内塞栓術および親動脈閉塞術の実際

遠藤英徳, 松本康史, 近藤竜史, 鈴木一郎, 菊池登志雄, 冨永悌二

Neurological Surgery　40　(12)　1107-1118　2012年12月
出版者・発行元： (株)医学書院
ISSN： 0301-2603
前脈絡叢動脈のvariationに関連した未破裂脳動脈瘤の2例

遠藤英徳, 松本康史, 近藤竜史, 高橋明, 冨永悌二

東北脳血管障害研究会学術集会記録集　34回　137-152　2012年12月
出版者・発行元：サノフィ(株)仙台オフィス
ISSN： 1880-9278
出血性椎骨動脈解離に対するinternal coil trappingにおける術後延髄梗塞の転帰への影響

遠藤英徳, 松本康史, 近藤竜史, 佐藤健一, 藤村幹, 井上敬, 清水宏明, 藤原悟, 高橋明, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　6　(5)　207-207　2012年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072
脳底動脈窓形成部動脈瘤一連の症例と血管内治療の役割(Basilar Artery Fenestration Aneurysms: Case Series and Role of Endovascular Therapy)

Sultan Ahmed, 松本康史, 遠藤英徳, 近藤竜史, 藤原悟, 高橋明, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　6　(5)　320-320　2012年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072
内頸動脈後交通動脈分岐部破裂脳動脈瘤におけるコイル塞栓術後の視床穿通枝梗塞

遠藤英徳, 佐藤健一, 松本康史, 近藤竜史, 井上敬, 清水宏明, 藤原悟, 高橋明, 冨永悌二

脳循環代謝　24　(1)　164-164　2012年11月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401
けいれん発作後経時的イオマゼニール結合能評価

井上敬, 清水宏明, 藤村幹, 遠藤英徳, 荻田庄吾, 藤原悟, 冨永悌二

脳循環代謝　24　(1)　170-170　2012年11月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401
CFD解析による脳動脈瘤壁硬化病変予測の可能性

新妻邦泰, 杉山慎一郎, 井上敬, 遠藤英徳, 藤村幹, 佐藤健一, 清水宏明, 高橋明, 冨永悌二

脳循環代謝　24　(1)　195-195　2012年11月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401
ステント留置術後にmicroembolic signalの消失を確認した頸部内頸動脈狭窄症の1例

近藤竜史, 松本康史, 佐藤健一, 遠藤英徳, 佐藤祥一郎, 古井英介, 板橋亮, 矢澤由加子, 藤原悟, 高橋明, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　6　(2)　114-121　2012年8月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072
2. 治療困難な脳動脈瘤 : 血管内手術に残された課題(PS3-3 脳動脈瘤治療に残る課題,プレナリーセッション,脳神経外科学の課題,第32回日本脳神経外科コングレス総会)

松本康史, 近藤竜史, 佐藤健一, 遠藤英徳, 高橋明, 冨永悌二

脳神経外科ジャーナル　21　88-88　2012年4月20日
出版者・発行元：日本脳神経外科コングレス
ISSN： 0917-950X
rt-PA静注療法後にMerciリトリーバーにて完全再開通が得られた内頸動脈閉塞の一症例

板橋亮, 古井英介, 突田健一, 矢澤由加子, 佐藤祥一郎, 遠藤英徳, 佐藤健一, 近藤竜史, 松本康史, 藤原悟, 森悦朗

臨床神経学　52　(2)　121-121　2012年2月
出版者・発行元： (一社)日本神経学会
ISSN： 0009-918X
脳動静脈奇形 ONYXの出現による治療の変化摘出術前AVM塞栓術 OnyxとNBCAの治療成績の比較

遠藤英徳, 松本康史, 近藤竜史, 佐藤健一, 高橋明, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　5　(4)　151-151　2011年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072
硬膜動静脈瘻新たな治療戦略の展開根治困難な多発性硬膜動静脈瘻に対する複合治療

近藤竜史, 松本康史, 佐藤健一, 遠藤英徳, 藤原悟, 城倉英史, 川岸潤, 高橋明, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　5　(4)　155-155　2011年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072
エンタープライズを用いたステント支援瘤内塞栓術の初期成績

近藤竜史, 松本康史, 佐藤健一, 遠藤英徳, 藤原悟, 高橋明, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　5　(4)　187-187　2011年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072
複数回の脳血管撮影を受ける患者における不安変動とその要因

梅田康弘, 大場倫史, 佐々木志保, 遠藤英徳, 近藤竜史, 松本康史

JNET: Journal of Neuroendovascular Therapy　5　(4)　202-202　2011年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072
内頸動脈-後交通動脈分岐部破裂脳動脈瘤のコイル塞栓術後交通動脈起始部を含めてコイル閉塞した場合の視床穿通枝梗塞の予測因子について

遠藤英徳, 松本康史, 近藤竜史, 佐藤健一, 高橋明, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　5　(4)　345-345　2011年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072
Merciリトリーバー導入はIV-tPA治療例の転帰を改善するかもしれない

板橋亮, 古井英介, 川田健太, 矢澤由加子, 佐藤祥一郎, 遠藤英徳, 佐藤健一, 近藤竜史, 松本康史, 藤原悟, 森悦朗

JNET: Journal of Neuroendovascular Therapy　5　(4)　380-380　2011年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072
脳梗塞急性期頸動脈ステント留置術の周術期脳循環動態の検討

遠藤英徳, 松本康史, 近藤竜史, 清水宏明, 冨永悌二

脳循環代謝　23　(1)　120-120　2011年11月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401
ラットくも膜下出血後のacute brain injuryに対するedaravoneの治療効果

新妻邦泰, 藤村幹, 遠藤英徳, 清水宏明, Chan Pak H, 冨永悌二

脳循環代謝　23　(1)　167-167　2011年11月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401
【動脈解離と脳卒中】椎骨脳底動脈解離(経時変化) 破裂椎骨動脈解離治療後に対側椎骨動脈解離をきたした1例

遠藤英徳, 松本康史, 近藤竜史, 佐藤健一, 清水宏明, 冨永悌二

The Mt. Fuji Workshop on CVD　29　173-176　2011年7月
出版者・発行元： (株)にゅーろん社
ISSN： 0289-8438

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45歳男。クモ膜下出血で発症した左椎骨動脈解離に対してendovascular trappingを行い、3日後、右椎骨動脈に解離が新生した。原因として、左椎骨動脈の塞栓により右椎骨動脈のhemodynamic stressが増加し、解離新生に関与した可能性が考えられた。右椎骨動脈解離に対しては保存的に経過観察を行い、5年後の現在まで同部に変化は認めていない。
頸動脈プラークを含めた全身血管病変の超音波診断頸部内頸動脈狭窄例では大動脈・末梢動脈病変を高率に合併する

矢澤由加子, 古井英介, 板橋亮, 佐藤祥一郎, 松本康史, 近藤竜史, 佐藤健一, 遠藤英徳, 藤原悟

Neurosonology　24　(増刊)　41-41　2011年6月
出版者・発行元： (一社)日本脳神経超音波学会
ISSN： 0917-074X
【脳血管バイパス術】内頸動脈系閉塞性脳血管病変に対するSTA-MCA bypass術後の急性期画像評価査読有り

遠藤英徳, 藤村幹, 井上敬, 清水宏明, 冨永悌二

脳卒中の外科　39　(3)　163-168　2011年5月
出版者・発行元： (一社)日本脳卒中の外科学会
ISSN： 0914-5508

eISSN： 1880-4683

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2008年4月〜2009年12月に浅側頭動脈・中大脳動脈(STA-MCA)吻合術を施行した閉塞性脳血管病変8例(男性7例、女性1例、平均62.3歳)を対象に、内頸動脈系閉塞性脳血管病変に対する術後急性期画像評価の有用性を検討した。全例で術前にXe-SPECTを撮影し、発症急性期に血行再建術を行った1例を除く7例で術前にDiamox負荷Xe-SPECTを施行した。安静時脳血流は8例中6例で低下し、脳循環予備能は7例全例で低下していた。内頸動脈系閉塞性脳血管病変に対するSTA-MCA吻合術は安全かつ有効な治療と考えられた。術後急性期の画像評価により、過灌流の有無、バイパス開存性、虚血性・出血性合併症の有無が早期から把握され、病態把握に基づいた安全な周術期管理が可能になると思われた。
類もやもや病に合併した大型中大脳動脈瘤の一手術例

遠藤英徳, 藤村幹, 井上敬, 藤原悟, 清水宏明, 冨永悌二

東北脳血管障害研究会学術集会記録集　32回　51-54　2010年12月
出版者・発行元：サノフィ(株)仙台オフィス
ISSN： 1880-9278

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症例は69歳女性で、一過性構音障害で近医にてMRI上異常所見を指摘され当院に入院した。FLAIR及びT2WIで基底槽と左シルビウス裂に沿ったクモ膜下出血と左大脳半球に陳旧性脳梗塞、脳血管撮影では両側内頸動脈終末部近傍に閉塞・狭窄性変化と周囲にもやもや血管の増生、左中大脳動脈分岐部にblebを伴う径14mmの大型嚢状動脈瘤とその近位のM1に高度狭窄、SPECTで左大脳半球の著明な循環予備能低下を認めた。類もやもや病と診断し開頭手術を行った。左前頭側頭開頭で脳表のクモ膜下出血を除去し、シルビウス裂を剥離してM1を遠位に辿り、動脈瘤をclippingした。脳虚血防止にsuperficial temporal artery-middle cerebral artery bypassを行って終了した。術翌日のMRI・MRAで出血性・虚血性合併症は認めず、IMP-SPECTで脳血流量の著明な増加を認め、過灌流予防に厳重な血圧管理を行った。術後3週間で神経脱落症状なく自宅退院した。
新世代のCAS 治療適応とデバイス選択頸部頸動脈狭窄症連続94症例に対するWallstent RPを使用した頸動脈ステント留置術周術期評価と長期成績

遠藤英徳, 松本康史, 近藤竜史, 佐藤健一, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　4　(4)　150-150　2010年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072
皮質静脈逆流を伴う硬膜動静脈瘻における脳実質侵襲の評価拡散強調画像による検討

佐藤健一, 清水宏明, 松本康史, 近藤竜史, 遠藤英徳, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　4　(4)　206-206　2010年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072
Bioactive coilを用いた脳動脈瘤塞栓術の1年後画像転帰

近藤竜史, 松本康史, 佐藤健一, 遠藤英徳, 藤原悟, 清水宏明, 高橋明, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　4　(4)　211-211　2010年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072
内頸動脈眼動脈分岐部動脈瘤および内頸動脈前壁嚢状動脈瘤に対する瘤内塞栓術の中期成績

近藤竜史, 松本康史, 佐藤健一, 遠藤英徳, 藤原悟, 清水宏明, 高橋明, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　4　(4)　327-327　2010年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072

eISSN： 2186-2494
経口腔血管超音波検査を用いてCAS後の内頸動脈径拡張を観察できた一例

松森保彦, 松本康史, 近藤竜史, 佐藤健一, 遠藤英徳, 矢澤由加子, 佐藤祥一郎, 板橋亮, 古井英介

JNET: Journal of Neuroendovascular Therapy　4　(4)　350-350　2010年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072
頸動脈ステント留置術適応症例の半数はアクセスルートに危険な血管病変を有する

矢澤由加, 突田健一, 佐藤祥一郎, 板橋亮, 古井英介, 遠藤英徳, 佐藤健一, 近藤竜史, 松本康史, 藤原悟

JNET: Journal of Neuroendovascular Therapy　4　(4)　364-364　2010年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072
小児もやもや病の治療戦略小児もやもや病に対するSTA-MCA吻合術の治療成績について術後急性期脳血流評価による周術期合併症の回避

藤村幹, 井上敬, 遠藤英徳, 斎藤敦志, 清水宏明, 冨永悌二

小児の脳神経　35　(2)　181-181　2010年4月
出版者・発行元： (一社)日本小児神経外科学会
ISSN： 0387-8023
経過中に後天性血友病を発症したくも膜下出血の1症例査読有り

齋藤竜太, 高橋俊栄, 遠藤英徳, 木村尚人, 金子宇一

Neurological Surgery　37　(12)　1215-1219　2009年12月
出版者・発行元： (株)医学書院
ISSN： 0301-2603

eISSN： 1882-1251

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症例は61歳男性で、近医にて大腸癌摘出術後10日目に突然悪寒・発熱に続き敗血症性ショックをきたしたが、抗生剤投与でショック状態から脱した2日後に一過性意識消失があり、CTにてクモ膜下出血と診断され紹介転送となった。来院時、CT上後頭蓋窩に強いクモ膜下出血と水頭症を認め、クモ膜下出血Hunt & Kosnik分類grade 3と診断、緊急血管撮影により右椎骨動脈の後下小脳動脈分岐遠位に解離性動脈瘤を認めた。同日、親動脈塞栓術+脳室ドレナージ術を施行、発症10日目頃より次第に解熱して経鼻経管栄養状態で安定し、回復期リハビリテーションへの移行を考慮していた発症後28日目に嘔気・嘔吐が出現、水頭症が原因と考え発生31日目に脳室〜腹腔短絡術を施行した。それを機に出血傾向が顕在化しコントロール困難となり、敗血症性ショックによる抗生剤長期使用後であったことから後天性血友病危険群と考えられた。治療には遺伝子組換え活性型第VII因子製剤を投与したが、約1ヵ月後に死亡した。
末梢性上小脳動脈瘤破裂の一例

高橋俊栄, 遠藤英徳, 野下展生, 大沢伸一郎, 金子宇一

JNET: Journal of Neuroendovascular Therapy　3　(4)　236-236　2009年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072
ラット全脳虚血後の遅発性海馬CA1神経細胞死におけるPUMAの役割について

新妻邦泰, 藤村幹, 遠藤英徳, 斉藤敦志, 清水宏明, チャン・パク・フー, 冨永悌二

脳循環代謝　21　(1)　115-115　2009年11月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401
中大脳動脈閉塞に伴うleptomeningeal anastomosis上に発生した破裂脳動脈瘤の1例査読有り

成澤あゆみ, 高橋俊栄, 齋藤竜太, 佐藤健一, 遠藤英徳, 野下展生, 金子宇一

Neurological Surgery　37　(8)　787-792　2009年8月
出版者・発行元： (株)医学書院
ISSN： 0301-2603

eISSN： 1882-1251

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83歳男。見当識障害、右不全麻痺を主訴とした。単純CT、MRIでは左後頭葉楔前部皮質下に脳内血腫を認めるのみで、くも膜下出血(SAH)は伴わないが、複数回の出血が疑われた。脳血管造影では左中大脳動脈(MCA) anterior trunkが閉塞し、左後大脳動脈(PCA)からの側副血行路として発達したMCA anterior trunk末梢のleptomeningeal anastomosis上に長径3mmの動脈瘤を認めたため、血腫を吸引除去して減圧を図った後、動脈瘤のクリップ閉塞を行った。術後の脳血管撮影では動脈瘤が消失しており、新たな神経学的異常所見を認めることなく、症状は改善した。画像上明らかなSAHを認めない脳内血腫であっても、動脈瘤の可能性を考慮して診断を進める必要があると思われた。
後下小脳動脈遠位部破裂動脈瘤の治療経験~自験例6例の検討~

遠藤英徳, 高橋俊栄, 野下展生, 大沢伸一郎, 金子宇一

日本脳神経外科学会総会抄録集(CD-ROM)　68th　2009年

ISSN： 1347-9040
ラット全脳虚血後の遅発性海馬CA1神経細胞死におけるPIDDosomeの役割について

新妻邦泰, 藤村幹, 遠藤英徳, 斉藤敦志, 清水宏明, CHAN PH, 冨永悌二

日本脳神経外科学会総会抄録集(CD-ROM)　68th　2009年

ISSN： 1347-9040
社会への責任脳神経外科医療圏再構築の必要性 2つの政令指定都市の総合病院脳神経外科入院状況の比較から

梅澤邦彦, 高橋俊栄, 丸山大輔, 竹上徹郎, 濱崎公順, 木村尚人, 遠藤英徳, 金子宇一

日本脳神経外科学会総会CD-ROM抄録集　67回　3J-08　2008年10月
出版者・発行元： (一社)日本脳神経外科学会
ISSN： 1347-9040
チマメないし解離性破裂内頸動脈瘤の治療戦略

遠藤英徳, 清水宏明, 藤村幹, 井上敬, 冨永悌二

日本脳神経外科学会総会CD-ROM抄録集　67回　2H-O33　2008年10月
出版者・発行元： (一社)日本脳神経外科学会
ISSN： 1347-9040
腰髄血管周皮腫の一例

遠藤英徳, 村上謙介, 隈部俊宏, 渡辺みか, 小澤浩司, 冨永悌二

脊髄外科　22　(1)　33-37　2008年6月
出版者・発行元： (一社)日本脊髄外科学会
DOI： 10.2531/spinalsurg.22.33 　

ISSN： 0914-6024

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症例は62歳男性で、1年前から足底部から上向する右下肢のしびれを自覚し、次第に両下肢麻痺をきたした。MRIでL1レベルに腫瘍性病変を認め、4ヵ月の経過で増大傾向を示した。両下肢全知覚障害、右下腿疼痛、膀胱直腸障害を認め、MRIでは腫瘍は1.5×1.0×1.5cmで髄内外に存在し、髄外病変は硬膜に付着しているようであった。T12からL2にかけての椎弓切除を行い、脊髄表面に血管に富む腫瘍組織を認めた。栄養血管を切除し髄内成分と脊髄との境界は明瞭であったので、これを慎重に剥離してen blockに腫瘍を摘出した。病理所見から血管周皮腫と診断された。術後より両下肢麻痺、知覚障害は改善し、リハビリテーションの後、術後48日で独歩退院した。
PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats.

Kuniyasu Niizuma, Hidenori Endo, Chikako Nito, D. J. Myer, Gab S. Kim, Teiji Tominaga, Pak H. Chan

STROKE　39　(2)　668-668　2008年2月

ISSN： 0039-2499
くも膜下出血急性期脳損傷 SOD1過剰発現による酸化ストレス減少とAkt/GSK3β生存シグナル活性化の影響

遠藤英徳, 藤村幹, Pak H. Chan, 冨永悌二

神経外傷　30　(2)　102-108　2007年12月
出版者・発行元： (一社)日本脳神経外傷学会
ISSN： 0389-5610

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くも膜下出血(SAH)後の急性期脳損傷と酸化ストレスとの関係を解明するため、copper/zinc-superoxide dismutase(SOD1)過剰発現ラットを用いAkt/GSK3β生存シグナル経路に着目して研究を行った。その結果、SOD1過剰発現によってSAH後のスーパーオキシド増加に伴う酸化型ハイドロエチジンの増加と大脳皮質でのアポトーシスが抑制され、SAH 24時間後の死亡率は有意に減少した。また、SAH後の大脳皮質の神経細胞においてAktとGSK3βのリン酸化が促進し、これらはSOD1過剰発現下で持続的に増加した。SOD1の過剰発現は酸化ストレスを軽減し、Akt/GSK3β生存シグナル経路の活性化を介して神経保護作用を発揮することが示された。
親血管閉塞により救命し得た破裂脳底動脈瘤の一症例

高橋俊栄, 木村尚人, 遠藤英徳, 斎藤竜太, 梅澤邦彦, 金子宇一

JNET: Journal of Neuroendovascular Therapy　1　(2)　232-232　2007年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072
TruFill Orbitにて塞栓し得た脳底動脈-前下小脳動脈分岐部動脈瘤破裂によるくも膜下出血の一例

木村尚人, 江面正幸, 高橋俊栄, 遠藤英徳, 斎藤竜太, 金子宇一

JNET: Journal of Neuroendovascular Therapy　1　(2)　246-246　2007年11月
出版者・発行元： (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072
脳血管攣縮は解決されたのか? 劇症型spasmの出現、自験173例の検討から

梅澤邦彦, 高橋俊栄, 木村尚人, 遠藤英徳, 金子宇一

日本脳神経外科学会総会CD-ROM抄録集　66回　1C-O02　2007年10月
出版者・発行元： (一社)日本脳神経外科学会
ISSN： 1347-9040
甲状腺機能亢進症を合併した(類)もやもや病手術例の検討周術期管理と術後急性期脳循環動態について

遠藤英徳, 藤村幹, 冨永悌二

日本脳神経外科学会総会CD-ROM抄録集　66回　3K-P55　2007年10月
出版者・発行元： (一社)日本脳神経外科学会
ISSN： 1347-9040
脳虚血後の遅発性海馬CA1神経細胞死におけるp53の役割について

遠藤英徳, 藤村幹, チャンパク, 冨永悌二

脳卒中　29　(2)　385-385　2007年3月
出版者・発行元： (一社)日本脳卒中学会
ISSN： 0912-0726
くも膜下出血急性期脳損傷 SOD1過剰発現による酸化ストレス減少とAkt/GSK3β生存シグナル活性化の影響

遠藤英徳, 藤村幹, チャン・パク, 冨永悌二

日本神経外傷学会プログラム・抄録集　30回　67-67　2007年3月
出版者・発行元： (一社)日本脳神経外傷学会
くも膜下出血急性期脳損傷 SOD1過剰発現による酸化ストレス減少とAkt/GSK3β生存シグナル活性化の影響

遠藤英徳, 藤村幹, チャン・パク, 冨永悌二

脳循環代謝　18　(3)　110-110　2006年11月
出版者・発行元：日本脳循環代謝学会
ISSN： 0915-9401
Activated Akt/GSK3 beta signaling induces neuronal survival after subarachnoid hemorrhage in rats

H Endo, FS Yu, C Nito, H Kamada, PH Chan

STROKE　37　(2)　725-726　2006年2月

ISSN： 0039-2499
穿頭ドレナージ術にて治療した高齢者急性特発性硬膜下血腫の3症例

遠藤英徳, 府川修, 増山祥二, 川瀬誠

Neurological Surgery　32　(3)　271-276　2004年3月
出版者・発行元： (株)医学書院
ISSN： 0301-2603

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症例1(80歳男性),症例2(70歳男性),症例3(84歳女).いずれも重度意識障害を主訴とし,頭部に外傷痕はなく,頭部単純X線撮影でも骨折を認めず,CTにてmixed densityを示す硬膜下血腫を認めた.以上より,急性特発性硬膜下血腫と診断し,穿頭ドレナージ術を行った結果,意識は改善し,術後13〜27日目のCTにて血腫の消失が確認された
反復したガンマナイフ治療にて長期間結節状播種病変をコントロールし得た悪性上衣腫の2症例

遠藤英徳, 隈部俊宏, 城倉英史, 白根礼造, 吉本高志, 嘉山孝正

新潟医学会雑誌　118　(1)　64-64　2004年1月
出版者・発行元：新潟医学会
ISSN： 0029-0440
椎骨動脈本幹が責任血管と考えられた三叉神経痛の5手術例

増山祥二, 府川修, 川瀬誠, 遠藤英徳

磐城共立病院医報　24　(1)　22-29　2003年9月
出版者・発行元：いわき市立総合磐城共立病院
ISSN： 0916-3387

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特発性の三叉神経痛(TN)でその責任血管が椎骨動脈(VA)本幹であると考えられた5手術例について,治療法を中心に報告した.症例は男性3例,女性2例で,年齢は57〜79歳であった.治療法は神経血管減圧術(MVD)を全例に行った.いずれも圧迫血管がVA本幹であり,血管の転位が困難で,初期の2例ではVAにテフロンテープを用いてVAを移動させMVDを行い,最近の3例ではVAと三叉神経の間にダクロンファイバーを挿入し減圧した.MVD後4例は疼痛が消失し,1例も疼痛の軽減が得られたが,初期に手術を行った1例では顔面神経麻痺・聴力障害が永続的に残存した
前交通および前大脳動脈瘤破裂に伴う両下肢麻痺

遠藤英徳, 冨永悌二, 清水宏明, 吉本高志

脳卒中　25　(1)　150-150　2003年3月
出版者・発行元： (一社)日本脳卒中学会
ISSN： 0912-0726
脳・脊髄のMRI画像アトラス低血糖昏睡における一過性両側性内包病変拡散強調MRIによる検討

遠藤英徳, 清水宏明, 冨永悌二, 吉本高志

脳と神経　55　(2)　174-175　2003年2月
出版者・発行元： (株)医学書院
ISSN： 0006-8969
小児小脳膠芽腫の1例

遠藤英徳, 隈部俊宏, 昆博之, 吉本高志, 中里洋一

Neurological Surgery　30　(12)　1325-1329　2002年12月
出版者・発行元： (株)医学書院
ISSN： 0301-2603

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7歳女.頭痛を主訴とした.MRIで左小脳半球〜橋に腫瘍性病変を認め,小脳半球の病変は増強効果を伴った.増強効果を示す部分に関心領域を設定して測定したproton magnetic resonance spectroscopyでcholineの著明な上昇,N-acetyl aspartateの低下,lactateの出現を認め,悪性度の高い神経膠腫が予測された.腫瘍摘出術を行い,病理組織学的に膠芽腫と診断した.術後4ヵ月で局所再発と髄腔内播種を生じ,全経過10ヵ月で死亡した
頚動脈内膜剥離術における側頭部rSO2モニタリングの有用性

遠藤英徳, 上井英之, 清水宏明, 冨永悌二, 吉本高志

日本脳神経外科学会総会抄録集　61st　(CD-ROM Abstracts)　2002年

ISSN： 1347-9059

︎全件表示 ︎最初の5件までを表示

書籍等出版物 1

Hybrid Neurosurgeonのための疾患別臨床脳血管解剖テキスト

遠藤, 英徳, 大宅, 宗一

メディカ出版　2018年9月

ISBN: 9784840463096

産業財産権 1

血腫除去方法

小島英揮, 松崎尚洋, 遠藤英徳, 大沢伸一郎, 中川敦寛, 冨永悌二

産業財産権の種類: 特許権

共同研究・競争的資金等の研究課題 14

衝撃波印加パルスジェットメスによる軟組織温存下の硬組織破砕技術の開発

中川敦寛, 大谷清伸, 辻田哲平, 近野敦, 遠藤英徳, 川口奉洋, 原田成美, 進藤智彦

2026年4月1日～ 2029年3月31日
脳血管内圧解析による機能的・持続定量血管内腔評価法の開発

遠藤英徳

2026年4月1日～ 2029年3月31日
腰部脊柱管狭窄症の病態解明を目指したエラスチン架橋アミノ酸の定量分析

井上智夫, 臼杵豊展, 田代亮介, 新妻邦泰, 遠藤英徳, 遠藤俊毅, 大宅宗一

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2025年4月1日～ 2028年3月31日
電気生理学的情報を用いた膠芽腫浸潤病領域識別法の開発

下田由輝, 金森政之, 大沢伸一郎, 中川敦寛, 大城朝一, 遠藤英徳

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2024年4月1日～ 2027年3月31日
血管壁MRイメージングと数値流体解析を駆使した脳動脈瘤増大予測モデルの開発

面高俊介, 中川敦寛, 新妻邦泰, 杉山慎一郎, 園部真也, 遠藤英徳, 船本健一

2024年4月1日～ 2027年3月31日
S1PR1 agonistによる脳血液関門制御を介した脳梗塞の新規治療法開発

伊藤明, 新妻邦泰, 遠藤英徳

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2024年4月1日～ 2027年3月31日
人工知能を用いたもやもや病における病期進行予測モデルの開発

遠藤英徳, 中川敦寛, 新妻邦泰, 麦倉俊司, 杉山慎一郎, 園部真也, 植田琢也, 面高俊介

2023年4月1日～ 2026年3月31日
急性期脳梗塞における免疫血栓を標的とした新規治療法の開発

坂田洋之, 新妻邦泰, 遠藤英徳, 田代亮介, 鹿毛淳史

2023年4月1日～ 2026年3月31日
血管壁イメージングMRIと瘤内血流のAI解析による脳動脈瘤破裂点の推定

面高俊介, 中川敦寛, 新妻邦泰, 杉山慎一郎, 園部真也, 遠藤英徳, 船本健一

2021年4月1日～ 2024年3月31日

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本研究では近年明らかになったMRIにおける脳動脈瘤壁の造影効果を破裂点の予測に応用し、さらにCFD (数値流体解析: computational fluid dynamics) 解析及びAI (人工知能: artificial intelligence) 解析を組み合わせることで、従来は主に形態学的特徴から予測していた破裂点をより高い精度で予測する手法を確立する。初年度である当該当年度は後ろ向き研究として主に患者データの収集を行った。画像データ（MRI及び脳血管撮影の3次元データ）を院内放射線サーバーからPCへ移す作業を行った。予定していた約400例分のうち2/3程終了した。移行した画像データを用いて画像解析ソフトを用いた瘤壁造影効果の評価、流体解析ソフトを用いたCFD解析を同時に進めているところである。現在のところ中間結果の段階であるが破裂点の予測にはMRIにおける瘤壁造影効果は非常に有用であるとの結果が得られつつある。すなわちくも膜下血種の患者さんで術前に造影MRIを行うことで事前に破裂点を予測しうるとの結果が得られており今後解析が進むにつれて根拠が増すものと予想される。現在移行している画像データはAI解析にも活用でき、将来的にはAI解析も進めることを視野に入れている。関連する検討として同データベースを用いて切迫破裂例における瘤壁臓絵効果に関する検討を行い論文化（Omodaka S et al. J Neurosurg. 2022）、学会発表 (脳神経外科総会2021, Stroke 2022)を行い、瘤壁造影効果の臨床的意義を示すことができており本研究成果の一部であるとともに本研究を後押しする成果が得られている。
くも膜下出血後早期脳損傷の軽減をめざして：エダラボンのドラッグリポジショニング

針生新也, 新妻邦泰, 遠藤英徳, 伊藤明

2020年4月1日～ 2023年3月31日

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くも膜下出血は日本人に多くみられ、致死率および要介護率がそれぞれ40%または30%の未だに転帰不良の疾患である。その理由として、発症直後から手術治療に至るまでの間にも脳圧亢進や酸化ストレスなどに起因する細胞障害性変化が始まっており、くも膜下出血後早期脳損傷として注目されている。本研究では脳保護薬であるエダラボンによるくも膜下出血後早期脳損傷の抑制効果を研究することを目的とした。エダラボンはフリーラジカルスカベンジャーとして、急性期の脳梗塞に対してすでに臨床現場で汎用されている薬剤である。研究第一年度はendovascular perforationによるラットくも膜下出血モデルを作成し、レーザー血流計を用いた出血後の脳血流量低下の観測、エダラボン静脈内投与によるくも膜下出血24時間後の生存率の比較試験を行った。第二年度は前年に得られたエダラボンの至適濃度の投与を行ったモデルを用いて、エダラボンがもたらす神経機能保護効果と組織学的な細胞障害抑制効果の評価を行うべく研究に取り組んだ。ラットくも膜下出血モデルの脳組織から抽出した蛋白質溶解液を用いて断片化DNAの測定を行い、アポトーシスの評価とした。sham群、vehicle群、エダラボン群について比較した結果、vehicle群に対してエダラボン群で断片化DNAは有意に低値を示し、アポトーシスが抑制されているという結果であった。上記実験に時間を要してしまったために組織染色によるアポトーシスの評価や神経機能の行動評価実施には至らず、遅延が発生した状況であるが、次年度以降に研究を加速させたい。、
S1PR1シグナル制御による脳血液関門保護を介したくも膜下出血の新規治療法開発

伊藤明, 新妻邦泰, 遠藤英徳

2020年4月1日～ 2023年3月31日

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全脳卒中で最も予後不良であるくも膜下出血においては有効性を示した治療薬は存在しない。脳血液関門(Blood Brain Barrier, BBB)の機能不全は脳卒中における神経損傷の増悪に関与することが示唆されている。脳血管内皮細胞は治療標的としての潜在性を有するが、BBB機能を制御する内皮細胞シグナル経路の理解が乏しいことから脳卒中における血管内皮を標的とした新たな治療法の開発が進んでいない。くも膜下出血においても発症早期よりBBB機能が破綻し血管透過性亢進が進み二次脳損傷をもたらし転帰不良に寄与することが知られている。スフィンゴシン-1-リン酸(S1P)は細胞膜上のS1P受容体(S1PR)を介した内皮機能のモジュレーターである。脳血管においても血管内皮のS1PR1シグナルがBBBを調整し血管透過性制御に関与することが近年明らかとなっている。本研究は脳血管内皮細胞でのS1PR1シグナル調整によりくも膜下出血の転帰改善が得られるかどうかを動物実験によって検証することを目的としているが、昨年度は薬物的なS1PR1拮抗により野生型マウスにおいてくも膜下出血の転帰を悪化させることを明らかにし、本年度は血管内皮特異的遺伝子改変マウスを主に用いてその作用機序が血管内皮細胞での S1PR1シグナル拮抗によりもたらされていることを証明した。今後は、最終段階としてS1PR1刺激薬によるくも膜下出血における治療効果を検証したい。
エラスチン架橋アミノ酸に着目したもやもや病バイオマーカー診断法の確立

井上智夫, 冨永悌二, 藤村幹, 新妻邦泰, 遠藤英徳, 臼杵豊展

2019年4月1日～ 2022年3月31日

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本研究の目的は、臨床医学と有機化学の異分野融合型の学際型研究として、動脈壁の構成成分であるエラスチンの架橋アミノ酸desmosineおよびisodesmosineが、もやもや血管の増勢や脳出血、脳梗塞などの致命的となり得る脳血管イベントの発症を推測可能なバイオマーカーであるという作業仮説を検証し、もやもや病の病態評価に関する簡便かつ高精度な診断法を初めて開発することである。もやもや病患者ではウイリス動脈輪に内膜線維性肥厚、内弾性板の屈曲、中膜の菲薄化などが認められている。その為、動脈壁中膜の主要成分である弾性線維エラスチンが組織学的に破綻している可能性が示唆されるが、生体内での血液生化学的動態には不明な点が多い。したがって、本研究では血液などの臨床試料中のエラスチン架橋アミノ酸の変動をバイオマーカーとする前例のない、簡便かつ客観的で高精度なもやもや病の病期進行予測モデルを構築できる。本研究により、若年者脳梗塞の不要な治療行為の減少や医療費の多大な削減が期待される。また、がん、急性心筋梗塞、脳卒中の三大疾病のうち、脳卒中のみ早期診断が可能なバイオマーカーが開発されていないが、本手法はもやもや病以外の他の脳卒中治療への水平展開も可能と考えられる。もやもや病患者の体内動態に関する以下の3項目につき、計3年間の研究期間内に明らかにする。そして最終的には、もやもや病の診断および病期進行予測をより客観的に遂行する為のバイオマーカーを同定し得る簡易的スクリーニングキットの開発につなげることを目指し、もやもや病患者の臨床試料中のdesmosine/isodesmosineの定量分析をおこなった。
動脈瘤壁の治癒と穿通枝温存を両立する紡錘状動脈瘤治療用ステントの開発

遠藤英徳, 太田信, 仲井正昭, 荒船龍彦, 安西眸, 大谷清伸

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2017年4月1日～ 2020年3月31日

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紡錘状動脈瘤は動脈硬化や動脈解離を基盤として発生する特殊な動脈瘤である。嚢状動脈瘤と異なり、治療方法が確立しておらず、時として出血や梗塞を起こし、致命傷となる疾患である。本研究の目的は、紡錘状脳動脈瘤に対して、「瘤壁治癒」と「穿通枝温存」という、相反する事象を両立するステントの開発である。本研究期間内に紡錘状動脈瘤内部と穿通枝の流体力学的特徴及び動脈瘤壁の病理解剖学的構造を明らかにし、根治を目的としたストラットパターンと形状を開発し、ブタを用いた非臨床試験で「瘤壁治癒」と「穿通枝温存」の両立に関する概念実証の確立をめざす。本年度は、新規入院した患者に血管撮影を行い、情報収集を行った。2010年以降に出血で発症した紡錘状動脈瘤は67例存在し、6例でステントを併用した親動脈を温存した治療を行い、他の59例では親動脈閉塞を行った。ステント併用群では穿通枝梗塞は認めず、親動脈閉塞群では穿通枝梗塞を合併していた。これらの症例に対して、血管撮影のデータに基づいて、computational fluid dynamicsの解析を行い、紡錘状動脈瘤の壁における血行力学的パラメータとして壁せん断応力の時間平均と最大値、壁せん断応力が最大となる時間、せん断応力との標準偏差と平均値の比、oscillating shear index（OSI）、relative residence time（RRT）を含めたパラメータを算出して検討を行った。統計学的有意なデータは得られていないが、今後データを蓄積し、紡錘状動脈瘤の壁における血行力学的パラメータの標準化を行っていく予定である。また、流体工学的に血流阻害効果の得られる条件、停滞するながれ環境下においても血流停止が生じない分枝細血管の開存が維持される条件を明らかにすべく、研究を継続していく。
根治性と機能温存を両立する新規脳動脈解離治療用ステントの開発

遠藤英徳, 杉山慎一郎, 新妻邦泰, 仲井正昭, 中川敦寛

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

研究種目：Grant-in-Aid for Young Scientists (B)

研究機関：Tohoku University

2014年4月1日～ 2017年3月31日

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研究期間中に出血性椎骨動脈解離は計15例来院した．全例に脳血管撮影を行い，解離部の解剖学的特徴を検討し，解離周囲からの穿通枝の起始を確認した．血管撮影のデータを基に，computational fluid dynamicsの解析を行い，流体工学的に血流阻害効果の得られる条件を検討し，停滞する流れ環境下においても血流停止が生じず，分枝細血管の開存が維持される条件を検討した．シミュレーションでは新規ステントデザインを作成可能であったが，患者毎の解離部の形状バリエーションが多いこと，穿通枝を血管撮影で視認不可能な場合も多いこと，などから実際に臨床応用可能な新規ステントを開発するには至らなかった．

︎全件表示 ︎最初の5件までを表示