東北大学研究者紹介

研究者詳細

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日本語 English

顔写真

ナカヤ　ナオキ

中谷　直樹

Naoki Nakaya

所属

東北メディカル・メガバンク機構　予防医学・疫学部門

職名

教授

学位

博士（障害科学）（東北大学）
修士（障害科学）（東北大学）

researchmap

https://researchmap.jp/read0065455

J-GLOBAL ID

200901091009413310

経歴 9

2021年～継続中

東北大学東北メディカル・メガバンク機構予防医学・疫学部門　教授
2019年～

埼玉県立大学保健医療福祉学部健康開発学科、埼玉県立大学大学院保健医療福祉学研究科　教授
2015年～

東北大学東北メディカル・メガバンク機構予防医学・疫学部門　准教授
2012年～

東北大学東北メディカル・メガバンク機構予防医学・疫学部門講師
2010年～

鎌倉女子大学家政学部管理栄養学科専任講師
2008年～

日本学術振興会海外特別研究員 (Danish Cancer Society, Copenhagen, Denmark)
2005年～

東北大学大学院医学系研究科公衆衛生学分野助手（助教）
2004年～

国立がんセンター研究所支所精神腫瘍学研究部（リサーチ・レジデント）
2003年～

東北大学大学院医学系研究科公衆衛生学分野（研究支援員）

︎全件表示 ︎最初の5件までを表示

学歴 3

東北大学大学院医学系研究科障害科学専攻博士課程後期３年の課程修了東北大学博士（障害科学）

2003年～
東北大学大学院医学系研究科障害科学専攻博士課程前期２年の課程修了東北大学修士（障害科学）

2000年～
麻布大学環境保健学部環境保健学科卒業

1998年～

委員歴 62

査読）Geriatrics & Gerontology International

2025年～継続中
査読）Am J Prev Med

2025年～継続中
査読）Psycho-Oncology （2025年ｘ2）

2025年～継続中
査読）Cureus

2025年～継続中
査読）Hypertension Research

2024年～継続中
査読）J Psychiatric Research (2022年×２、2023年×２)

2022年～継続中
Reviewer Board）Japanese Journal of Clinical Oncology (2021-)

2021年～継続中
査読）Perspectives in Public Health

2021年～継続中
査読）Preventive Medicine（2021×2）

2021年～継続中
査読）Public Health (2021×3, 2022×1)

2021年～継続中
委員）戸田市保健対策推進協議会委員（会長）

2019年4月～ 2021年3月
委員）弘前大学COI健康・医療データ連携推進機構運営委員会委員

2017年～ 2018年
査読）日本行動医学会プログラム編集員

2015年～ 2015年
委員）国際行動医学会プログラム編集委員:

2008年～ 2008年
Social Science & Medicine (2024年、2025年)

2024年～
Dementia and Geriatric Cognitive Disorders（2023年）

2023年～
委員）日本サイコオンコロジー学会代議員 2023-24, 2025-26

2023年～
査読） Journal of Alzheimer’s Disease

2023年～
査読）Disaster Medicine and Public Health Preparedness

2021年～
査読）Preventive Medicine Reports（2020, 2024）

2020年～
査読）Complementary Therapies in Clinical Practice (×2)

2020年～
査読）Environmental Health and Preventive Medicine（2020✖2)

2020年～
査読）European Journal of Clinical Nutrition（2020✖２）

2020年～
査読）BMC Medical Research Methodology

2020年～
査読）Journal of Psychosocial Oncology Research and Practice (2019, 2020)

2019年～
査読）Japanese Journal of Clinical Oncology

2019年～
査読）Neuropsychopharmacology Reports

2019年～
査読）Psychiatry and Clinical Neruoscience

2018年～
査読）Social Psychiatry and Psychiatric Epidemiology (2018, 2020×5, 2021×2）

2018年～
査読）Scientific Reports (2018年, 2022年）

2018年～
査読）Disability and Rehabilitation (2017年、2018年×２、2023年×２）

2017年～
査読）Tohoku Journal of Experimental Medicine (2017年、2019年×2、2022年、2024年)

2017年～
査読）Journal of Atherosclerosis and Thrombosis

2017年～
査読）Case Reports in Medicine

2017年～
査読） BMJ Open（2016年、2022年×2）

2016年～
査読）Journal of Negative Results in BioMedicine

2016年～
査読）BMC Geriatrics

2015年～
査読）Cancer Epidemiology

2015年～
査読）European Journal of Public Health

2014年～
査読）Environmental Health and Preventive Medicine（2014年、2015年、2018年）

2014年～
査読） Plos One (2014年＊2, 2016年）

2014年～
査読） British Journal of Cancer

2013年～
査読） Journal of Physical Therapy Science

2013年～
査読） International Journal of Neuroscience

2013年～
査読） BMC Cancer

2013年～
査読） Journal of the National Cancer Institute

2012年～
査読） Psychooncology (2012年、2013年、2014年、2015年、2018年)

2012年～
査読） European Journal of Psychotherapy & Counselling

2012年～
査読） Nephrology Dialysis Transplantation

2012年～
査読） Journal of Affective Disorders (2012年、2016、2017年、2018年×2、2019年×2、2020年×3、2023年）

2012年～
査読） Patient Preference and Adherence

2011年～
査読） Spanish Journal of Psychology

2011年～
査読）行動医学研究

2010年～
査読） American Journal of Epidemiology

2010年～
査読） International Journal of Cancer (2009年、2015年、2018年×２、2024年)

2009年～
査読） Journal of Epidemiology (2008年、2009年、2010年、2012年、2014年、2015年、2020年×2、2021年×3)

2008年～
査読） BMC Public Health

2008年～
査読） BioPsychoSocial Medicine

2008年～
査読） Acta Oncologica

2008年～
査読） Preventive Medicine

2007年～
査読） Journal of Psychosomatic Research（2007、2020）

2007年～
委員）日本疫学会評議員 2013-14、日本疫学会代議員 2015-16, 2017-18, 2021-22, 2023-24, 2025-26

︎全件表示 ︎最初の5件までを表示

所属学協会 3

日本公衆衛生学会
日本サイコオンコロジー学会
日本疫学会（上級疫学専門家2019-)

研究キーワード 33

一般地域住民
生存分析
危険因子
生活習慣
前立腺がん
心理社会的要因
健康影響
身体的要因
症例対照研究
ストレス
縦断的研究
がん患者
配偶者
がん
心理的苦痛
前向きコホート研究
疫学
自殺
うつ
集団認知行動療法
カテキン
緑茶
ω3系脂肪酸
サイコオンコロジー (Psychooncology)
応用健康科学 (Applied Health Science)
公衆衛生学 (Public Health)
疫学 (Epidemiology)
Public Health
Epidemiology
Applied Health Science
Stress Science
Behavioral Medicine
Psychosomatic Medicine

研究分野 3

社会基盤（土木・建築・防災） / 防災工学 /
ライフサイエンス / 衛生学、公衆衛生学分野：実験系を含まない /
ライフサイエンス / 栄養学、健康科学 /

受賞 7

日本疫学会優秀査読者賞, 2022年

2022年
日本疫学会総会ポスター賞, 2016年1月

2016年
「黒川利雄がん研究基金」研究助成金採択, 2014年6月

2014年　財団法人宮城県対がん協会
日本疫学会奨励賞, 2013年 1月

2013年
日本行動医学会荒記記念賞, 2007年 3月

2007年
日本心身医学会池見賞, 2005年 4月

2005年
麻布大学環境科学研究会越智賞, 2000年 9月

2000年

︎全件表示 ︎最初の5件までを表示

論文 426

Combined association of social isolation and loneliness with frailty onset among independent older adults: A JAGES cohort study. 国際誌

Mamoru Sato, Manami Hoshi-Harada, Kenji Takeuchi, Taro Kusama, Takaaki Ikeda, Sakura Kiuchi, Masashige Saito, Naoki Nakaya, Ken Osaka

Archives of gerontology and geriatrics　136　105914-105914　2025年9月

DOI： 10.1016/j.archger.2025.105914 　

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OBJECTIVES: Social isolation and loneliness each have negatively affect various health outcomes. No studies have examined the combined association of social isolation and loneliness on frailty onset. This study aimed to investigate both the objective and subjective aspects of isolation by evaluating social isolation and loneliness and to determine their interaction effects on frailty onset. METHODS: This cohort study used data from the 2019 and 2022 Japan Gerontological Evaluation Study. The eligible participants were independent older adults aged ≥65 years without frailty in 2019. The outcome variable was frailty onset in 2022. The exposure variables were social isolation and loneliness in 2019. Risk ratios (RR) and 95 % confidence intervals (CI) were estimated using modified Poisson regression models, with potential confounders as covariates. Moreover, a multiplicative scale and relative excess risk due to interaction (RERI) was used to assess the interaction. RESULTS: The analysis included 8440 participants (mean age: 73.2 [standard deviation, 5.5] years). During the follow-up, 15.1 % of participants experienced frailty onset. After adjusting for all covariates, the "severe isolation" & "severe loneliness" group had the highest risk of frailty onset (RR = 2.09 [95 % CI: 1.60-2.73]) compared to "no isolation" & "no loneliness" group. However, there were no significant multiplicative and additive interaction between social isolation and loneliness on frailty onset (multiplicative scale: 0.75 [95 % CI: 0.50-1.11]; RERI:0.29 [95 % CI:1.02-0.44]). DISCUSSION: These findings highlight the importance of considering social factors such as interaction with others and loneliness, to prevent frailty.
Genetic predisposition for immunoglobulin E production explains atopic risk in children: Tohoku Medical Megabank cohort study. 国際誌

Yoichi Sutoh, Tsuyoshi Hachiya, Yayoi Otsuka-Yamasaki, Shohei Komaki, Shiori Minabe, Hideki Ohmomo, Kozo Tanno, Atsushi Hozawa, Naoki Nakaya, Aoi Noda, Masatsugu Orui, Mami Ishikuro, Taku Obara, Shinichi Kuriyama, Makoto Sasaki, Atsushi Shimizu

American journal of human genetics　2025年7月15日

DOI： 10.1016/j.ajhg.2025.06.015 　

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The atopic march lacks early identification methods for high-risk children. In this study, we assessed whether the risk of atopic diseases in infants could be predicted using a polygenic score (PGS) for total immunoglobulin E (IgE) levels. The PGS estimated using the polygenic model generated by PRS-CS was significantly correlated with log-transformed IgE levels (ρ = 0.200, p < 2.2 × 10-16). Assessment of the risk from birth to 2 years of age in a Japanese birth cohort (n = 17,154) applying the estimated PGS revealed significantly elevated incidence risk ratios in the highest PGS quintile (Q5) compared with those in the reference quintiles (Q1-Q3) for food allergy (1.51-fold; 95% confidence interval: 1.30-1.76), atopic dermatitis (1.30-fold; 1.12-1.51), and both conditions (1.88-fold; 1.46-2.43). These findings address critical gaps in allergy and PGS research among non-European populations, suggesting the contribution of genetic predisposition to IgE production in early-onset allergic diseases and supporting the use of PGS in early intervention.
Association between urinary sodium-to-potassium ratio and BNP in a general population without antihypertensive treatment and cardiovascular diseases: the Ohasama study. 国際誌

Tomoko Muroya, Michihiro Satoh, Hirohito Metoki, Shingo Nakayama, Takuo Hirose, Takahisa Murakami, Yukako Tatsumi, Ryusuke Inoue, Megumi Tsubota-Utsugi, Azusa Hara, Mana Kogure, Naoki Nakaya, Kei Asayama, Kyoko Nomura, Masahiro Kikuya, Atsushi Hozawa, Takayoshi Ohkubo

Hypertension research : official journal of the Japanese Society of Hypertension　2025年6月27日

DOI： 10.1038/s41440-025-02266-0 　

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The urinary sodium-to-potassium (Na/K) ratio is associated with blood pressure (BP) and cardiovascular risk. We examined the association between the urinary Na/K ratio and brain natriuretic peptide (BNP), a biomarker indicative of cardiac stress levels within the general population. This cross-sectional study included 436 participants (mean age: 65.4 ± 6.9 years; 73.2% women) without antihypertensive medications or cardiovascular diseases (including atrial fibrillation) from the Ohasama Study. The urinary Na/K ratio was calculated using casual daytime spot urine samples. Analyses of covariance and multiple linear and Poisson regression models were conducted. The median BNP value was 18.6 pg/mL (interquartile range: 11.4-31.2 pg/mL). Participants in the first (≤2.19), second (2.19-3.27), and third (≥3.28) tertiles of the urinary Na/K ratio had adjusted mean natural log-transformed (ln)BNP of 2.74, 2.88, and 3.06 (converted BNP values: 15.50, 17.81, and 21.37 pg/mL), respectively, after adjusting for covariates including estimated glomerular filtration rate, home systolic BP, and Sokolow-Lyon voltage (P for trend = 0.0005). The adjusted prevalence ratios (95% confidence intervals) for BNP ≥35 pg/mL were 1.27 (0.76-2.14) and 2.24 (1.35-3.72) in the second and third tertiles, respectively, compared with the lowest tertile. The highest standardized regression coefficient for lnBNP was observed for the urinary Na/K ratio ( | 0.24 | ), surpassing estimated 24-h urinary sodium ( | 0.16 | ) or potassium ( | 0.09 | ) excretion. In conclusion, urinary Na/K ratio was associated with elevated BNP levels in individuals without antihypertensive treatment and cardiovascular disease history. This urinary marker may be valuable for early prevention of organ damage and cardiac burden.
Longitudinal association between the duration of eye gaze fixation on social information and specific symptoms of neurodevelopmental disorders in children: A large-scale community-based cohort study. 国際誌

Masatsugu Orui, Mami Ishikuro, Taku Obara, Aoi Noda, Genki Shinoda, Keiko Murakami, Hirohito Metoki, Masahiro Kikuya, Naoki Nakaya, Tomoko Nishimura, Keiko Tanaka, Yoshihiro Miyake, Atsushi Hozawa, Kenji J Tsuchiya, Shinichi Kuriyama

PCN reports : psychiatry and clinical neurosciences　4　(2)　e70095　2025年6月

DOI： 10.1002/pcn5.70095 　

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AIM: Autism spectrum disorder (ASD) is a neurodevelopmental condition clinically characterized by abnormalities in eye contact during social interactions. Eye-tracking systems have been used to screen individuals with ASD by capturing atypical eye gaze patterns of diagnostic significance, such as reduced duration of eye gaze fixation on social information. However, most prior studies have focused on the screening accuracy of eye-tracking systems in children already diagnosed with ASD, with few longitudinal assessments conducted on a large scale. This large-scale, longitudinal, community-based study aimed to analyze the association between specific neurodevelopmental symptoms and the duration of eye gaze fixation on social information within a community-based setting. METHODS: A longitudinal study involving 2101 participants utilized a generalized linear model (GLM) to examine associations between the duration of eye gaze fixation on social information at age 4 years and subscale scores of the Strengths and Difficulties Questionnaire (SDQ) at ages 6-7. RESULTS: GLM analysis revealed that shorter durations of eye gaze fixation on social information at age 4 years were significantly associated with emotional problems and peer problems, and with hyperactivity/inattention attention-deficit hyperactivity disorder (ADHD) at ages 6-7 years. CONCLUSION: These findings demonstrate the ability to detect not only peer problems characteristic of ASD but also hyperactivity/inattention characteristic of ADHD longitudinally, which it might be related to the comorbidity of ASD and ADHD. This preliminary study highlights the potential for neurodevelopmental screening; however, further research is needed to validate the accuracy of these methods.
Effects of dental prostheses and occlusal force on adverse health outcomes in community-dwelling older adults lacking functional dentition: The Longitudinal Study of the Tsurugaya Project. 国際誌

Daizo Seki, Takamasa Komiyama, Takashi Ohi, Yoshitada Miyoshi, Mana Kogure, Naoki Nakaya, Atsushi Hozawa, Yoshinori Hattori

The journal of nutrition, health & aging　29　(6)　100534-100534　2025年6月

DOI： 10.1016/j.jnha.2025.100534 　

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OBJECTIVE: In this study, we aimed to examine the longitudinal association between combination of remaining natural teeth (RNT) and functional teeth (FT) or occlusal force (OF), with functional disability and mortality among community-dwelling Japanese adults aged ≥70 years with less than 20 remaining teeth. METHODS: The participants included 916 community-dwelling Japanese adults aged 70 years or older in 2003. Exposures were defined as a combination of RNT and either FT or OF. Outcomes included the incidence of functional disability, determined by the first certification under Japan's long-term care insurance system based on physical and cognitive status, and mortality. The participants were followed up until June 2020. Covariates included age; sex; education; comorbidity; smoking; drinking; physical and cognitive status; and depressive symptoms. Cox proportional hazard models were applied to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for functional disability and death. RESULTS: We observed a higher incidence of death among participants with <20 RNT and fewer FT (<28) than those with functional dentition (HR: 1.62; 95% CI: 1.19-2.21). The HR for death increased as the oral health category based on RNT and FT worsened (p for trend = 0.003). We observed a higher incidence of functional disability (HR: 1.25; 95% CI: 1.02-1.53) and death (HR: 1.30; 95% CI: 1.01-1.68) among those participants with <20 RNT and reduced OF (<200 N) than those with ≥20 RNT. The HR for functional disability (p for trend = 0.029) and death (p for trend = 0.042) increased as the category based on RNT and OF worsened. CONCLUSION: This prospective cohort study demonstrated that a combination of <20 RNT and fewer FT was associated with a higher mortality, whereas a combination of <20 RNT and reduced OF was associated with higher incidence of functional disability and death. Dental prostheses and maintaining OF might play an important role in preserving functionality and promoting survival among older adults with less than 20 remaining teeth.
Association Between Sodium- and Potassium-Related Urinary Markers and the Prevalence of Atrial Fibrillation.

Sayuri Tokioka, Naoki Nakaya, Rieko Hatanaka, Kumi Nakaya, Mana Kogure, Ippei Chiba, Masato Takase, Kotaro Nochioka, Kai Susukita, Hirohito Metoki, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Satoshi Yasuda, Atsushi Hozawa

Circulation journal : official journal of the Japanese Circulation Society　89　(6)　757-764　2025年5月23日

DOI： 10.1253/circj.CJ-24-0780 　

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BACKGROUND: The primary prevention of atrial fibrillation (AF), which increases mortality through complications including stroke and heart failure, is important. Excessive salt intake and low potassium intake are risk factors for cardiovascular disease; however, their association with AF remains inconclusive. This study investigated the association between sodium- and potassium-related urinary markers and AF prevalence. METHODS AND RESULTS: Data from the Tohoku Medical Megabank Project Community-based Cohort Study were used in this cross-sectional study. The urinary sodium-to-potassium (Na/K) ratio and estimated 24-h sodium and potassium excretion were calculated using spot urine samples and categorized into quartiles (Q1-Q4). The prevalence of AF was the primary outcome. Of the 26,506 participants (mean age 64.8 years; 33.2% males) included in this study, 630 (2.4%) had AF. Using Q1 as the reference group, the odds ratios for AF prevalence in Q4 were 1.35 (95% confidence interval [CI] 1.07-1.73) and 1.59 (95% CI 1.20-2.12) for 24-h estimated urinary Na/K ratio and estimated 24-h sodium excretion, respectively. Estimated 24-h potassium excretion was not associated with AF prevalence. CONCLUSIONS: AF prevalence was positively associated with the urinary Na/K ratio and estimated 24-h urinary sodium excretion, but not with estimated 24-h urinary potassium excretion. Although further prospective studies are warranted, the findings of this study suggest that salt intake may be a modifiable risk factor for AF.
Degree of housing damage caused by the Great East Japan Earthquake and all-cause mortality in the community-based cohort study of the Tohoku Medical Megabank Project. 国際誌

Naoki Nakaya, Kumi Nakaya, Mana Kogure, Yuka Kotozaki, Rieko Hatanaka, Ippei Chiba, Sayuri Tokioka, Masato Takase, Satoshi Nagaie, Hideki Ohmomo, Takahito Nasu, Nobuo Fuse, Kozo Tanno, Atsushi Hozawa

Journal of epidemiology and community health　79　(6)　451-458　2025年5月9日

DOI： 10.1136/jech-2024-223084 　

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BACKGROUND: Natural disasters may have negative health effects on survivors. However, long-term observations on this are lacking. Therefore, this study investigated the association between the degree of housing damage caused by the Great East Japan Earthquake (GEJE) and all-cause mortality using the data from the cohort study conducted by the Tohoku Medical Megabank (TMM) Project in disaster-stricken areas. METHODS: The community-based cohort study of the TMM Project which conducted a baseline survey from May 2013 to March 2016 collected data using questionnaires and blood and urine tests. The present large-scale prospective cohort study was a follow-up survey in which the degree of house damage and all-cause mortality were analysed using Cox proportional hazards regression, adjusting for sex, age and other potentially confounding variables. The degree of house damage was categorised into 'did not live in the disaster area', 'no damage', 'small-scale damage' and 'large-scale damage'. Among the 58 320 participants, 1763 deaths were confirmed during the follow-up which averaged 6.5 years. RESULTS: The multivariate analysis showed a hazard ratio (95% CI) of 0.96 (0.82 to 1.13) for those who did not live in the disaster area, 0.98 (0.87 to 1.10) for small-scale damage and 0.98 (0.85 to 1.14) for large-scale damage, compared with no damage, but no significant association with all-cause mortality was observed. CONCLUSION: The results of this large-scale prospective cohort study of GEJE survivors showed no significant relationship between the degree of house damage and all-cause mortality. Further long-term follow-up studies are needed to examine the long-term health effects of natural disasters on survivors.
Concordance of Cancer Screening Attendance Among Spouse Couples: A Cross-Sectional Survey of the Tohoku Medical Megabank Project. 国際誌

Naoki Nakaya, Kumi Nakaya, Toshimasa Sone, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Sayuri Tokioka, Masato Takase, Yoko Izumi, Nobuo Fuse, Atsushi Hozawa

Psycho-oncology　34　(5)　e70158　2025年5月

DOI： 10.1002/pon.70158 　

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OBJECTIVES: Owing to spousal pairs often exhibiting similar health behaviors, this study examined the concordance of cancer screening attendance between spouses using cross-sectional data from a large biobank study in Japan, which included 2022 spousal pairs. STUDY DESIGN: Cross-sectional study. METHODS: Self-administered data were collected to determine whether participants had undergone screening for colorectal, gastric, and lung cancers in the past year. The following two analyses were conducted: the exposure was whether the husband attended cancer screening, and the outcome was whether the wife attended; the exposure was whether the wife attended, and the outcome was whether the husband attended. Multiple logistic regression analyses were performed, adjusting for confounding factors in the exposed individuals. RESULTS: The multivariate odds ratio (95% confidence interval, p-value) for wives attending colorectal cancer screening when their husbands had attended was 2.7 (2.2-3.3, p < 0.0001), indicating a significant positive association. Similarly, when wives were the exposure and husbands were the outcomes, the odds ratio was 2.6 (2.2-3.2, p < 0.0001). Notably, these associations were consistent across colorectal, gastric, and lung cancer screenings. CONCLUSIONS: The findings of this study support the hypothesis that the attendance of one spouse at cancer screening significantly positively influences that of the other spouse, regardless of the type of cancer screening or the age of the spouses. Novel intervention strategies can be developed that specifically target spousal pairs and potentially enhance the effectiveness of cancer prevention initiatives compared to those targeting individuals alone.
Genetic risk, lifestyle adherence, and risk of developing hyperuricaemia in a Japanese population. 国際誌

Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Akira Narita, Taku Obara, Mami Ishikuro, Hisashi Ohseto, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Koichi Matsuda, Yoko Izumi, Kengo Kinoshita, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

Rheumatology (Oxford, England)　64　(5)　2591-2600　2025年5月1日
出版者・発行元： Oxford University Press (OUP)
DOI： 10.1093/rheumatology/keae492 　

ISSN：1462-0324

eISSN：1462-0332

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Abstract Objective To investigate the inter-relationships among genetic risk, healthy lifestyle adherence, and hyperuricaemia susceptibility. Methods This prospective cohort study was conducted with 7,241 hyperuricaemia-free individuals aged ≥ 20 years from the Tohoku Medical Megabank Community-based cohort study. A comprehensive lifestyle score included body mass index, smoking, drinking, and physical activity, and a polygenic risk score (PRS) was constructed based on uric acid loci from a previous genome-wide association study meta-analysis. A multiple logistic regression model was used to estimate the association between genetic risk, healthy lifestyle, and hyperuricaemia incidence and calculate the area under the receiver operating characteristic curve (AUROC). Hyperuricaemia was defined as a uric acid level ≥7.0 mg/dl or a self-reported history of hyperuricaemia. Results Of the 7,241 adults (80.7% females; mean [SD] age: 57.7 [12.6] years), 217 (3.0%) developed hyperuricaemia during 3.5 years of follow-up. Genetic risk correlated with hyperuricaemia development (P for interaction = 0.287), and lifestyle risks were independently associated. Those with a high genetic risk and poor lifestyle had the highest risk (odds ratio: 5.34; 95% confidence interval [CI]: 2.61–12.10). Although not statistically significant, incorporating the PRS in the model with lifestyle information improved predictive ability (AUROC = 0.771, 95% CI: 0.736–0.806 for lifestyle; AUROC = 0.785, 95% CI: 0.751–0.819 for lifestyle and PRS; p = 0.07). Conclusion : A healthy lifestyle to prevent hyperuricaemia, irrespective of genetic risk, may mitigate the genetic risk. Genetic risk may complement lifestyle factors in identifying individuals at a heightened hyperuricaemia risk.
Sex difference in genetic risk in the prevalence of atrial fibrillation. 国際誌

Sayuri Tokioka, Masato Takase, Naoki Nakaya, Rieko Hatanaka, Kumi Nakaya, Mana Kogure, Ippei Chiba, Kotaro Nochioka, Hirohito Metoki, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Gen Tamiya, Nobuo Fuse, Shinichi Kuriyama, Satoshi Yasuda, Atsushi Hozawa

Heart rhythm　2025年3月23日

DOI： 10.1016/j.hrthm.2025.03.1974 　

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BACKGROUND: Early detection and management of atrial fibrillation (AF) are crucial. Combined models incorporating genetic risks and clinical risks have been developed to improve predictive ability. Although sex differences have been reported in many aspects of AF, sex differences in genetic risk have not been studied. OBJECTIVE: To assess the sex difference in the effect of AF-PRS on AF prevalence using cross-sectional data from the Tohoku Medical Megabank Project Community-Based Cohort Study in Japan. METHODS: Polygenic risk score for AF (AF-PRS) and Cohorts for Heart and Aging Research in Genomic Epidemiology AF (CHARGE-AF) score were used for genetic AF risks and clinical AF risks, respectively. Sex differences in the association of AF-PRS with the prevalence of AF were evaluated. RESULTS: Among 16,853 participants (mean age, 63.4 years and 30.7% men), the prevalence of AF was 4.9% in men and 1.1% in women. In the group with high AF-PRS and high CHARGE-AF score, the odds ratio for AF was highest in men and women (8.2 in men and 9.4 in women), compared to that in the group with low AF-PRS and low CHARGE-AF score. Integrating AF-PRS into the CHARGE-AF score significantly enhanced the area under the curve of receiver operating characteristic for AF in men (from 0.639 to 0.749) but not in women (from 0.710 to 0.733). CONCLUSION: Our study is the first to show a sex difference in the association of AF-PRS and AF prevalence. AF-PRS is more closely associated with the prevalence of AF in men than in women.
Trends in uptake of cancer screening among people with severe mental illness before and after the COVID-19 pandemic in Japan: A repeated cross-sectional study. 国際誌

Yuto Yamada, Masaki Fujiwara, Naoki Nakaya, Koji Otsuki, Taichi Shimazu, Maiko Fujimori, Shiro Hinotsu, Kiwamu Nagoshi, Yosuke Uchitomi, Masatoshi Inagaki

PCN reports : psychiatry and clinical neurosciences　4　(1)　e70062　2025年3月

DOI： 10.1002/pcn5.70062 　

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AIM: The aim of this study was to investigate trends in cancer screening participation among people with severe mental illness (PSMI) from periods before and after the COVID-19 pandemic. METHODS: In this repeated cross-sectional study, we used anonymized datasets on municipal cancer screening participation among PSMI in Okayama City. The data covered fiscal year (FY) 2018 to FY2022; we used the municipal cancer screening database and Medical Payment for Services and Supports for Persons with Disabilities. PSMI were defined as those with schizophrenia or related psychotic disorders (F20-29) or bipolar disorder (F30 or F31), identified using International Classification of Diseases, Tenth Revision, codes. The analysis included men and women aged 40-69 years for colorectal and lung cancer screening; men and women aged 50-69 years for gastric cancer screening; women aged 40-69 years for breast cancer screening; and women aged 20-69 years for cervical cancer screening. Municipal cancer screening rates among PSMI were calculated for each FY. RESULTS: For all cancer types, cancer screening rates for PSMI in FY2020 (colorectal: 9.0%; lung: 11.6%; gastric: 4.9%; breast: 6.2%; and cervical: 6.1%) were lower than the rates in FY2019 (11.5%, 14.0%, 6.5%, 9.3%, and 8.3%, respectively). In FY2022, the rates (9.9%, 12.9%; 5.3%; 8.0%, and 6.9%, respectively) recovered, but remained low. CONCLUSION: This study showed that cancer screening rates among PSMI were very low, both before and after the COVID-19 pandemic. Efforts to encourage participation in cancer screening in this population are urgently needed.
Number of teeth and functional disability in community-dwelling older adults. 国際誌

Takamasa Komiyama, Takashi Ohi, Yoshitada Miyoshi, Mana Kogure, Naoki Nakaya, Atsushi Hozawa, Ichiro Tsuji, Makoto Watanabe, Yoshinori Hattori

Gerodontology　42　(1)　86-92　2025年3月

DOI： 10.1111/ger.12775 　

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INTRODUCTION: This study determined whether tooth loss was associated with the development of functional disability and estimated the population attributable fraction (PAF) of functional disability due to tooth loss, along with risk factors for functional disability such as physical function and cognitive impairment. METHODS: The participants were 838 community-dwelling older adults aged ≥70 years living in the Tsurugaya district in Japan in 2003. The exposure variable was the number of remaining teeth (counted by trained dentists). Other variables were age, sex, depressive symptoms, cognitive impairment, educational attainment, physical function and social support. The Cox proportional hazards model was applied to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of the incidence of functional disability for each risk factor, such as tooth loss. The functional disability PAF due to tooth loss was estimated, and risk factors for functional disability were identified. RESULTS: In total, 619 (73.9%) participants developed functional disability during follow-up. A multivariable model showed that those with <20 teeth (HR, 1.28; 95% CI, 1.08-1.53) were more likely to develop functional disability than those with 20 teeth or more. PAF estimation for functional disability was shown to have decreasing values in the following order: age, female sex, tooth loss and reduced physical function. CONCLUSIONS: Tooth loss was associated with the development of functional disability in community-dwelling older Japanese adults. While retaining teeth may be a potential strategy for avoiding functional disability, clinical studies on the effect of dental treatment on preventing functional disability are warranted.
Association between equivalized annual household income and regular medical visits for hypertensive patients since the COVID-19 outbreak. 国際誌

Maya Toyama, Michihiro Satoh, Hideaki Hashimoto, Yutaro Iwabe, Takahito Yagihashi, Shingo Nakayama, Takahisa Murakami, Naoki Nakaya, Hirohito Metoki, Atsushi Hozawa, Takahiro Tabuchi

Hypertension research : official journal of the Japanese Society of Hypertension　48　(2)　786-795　2025年2月

DOI： 10.1038/s41440-024-02067-x 　

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Previous studies have shown an increase in blood pressure during the coronavirus disease 2019 (COVID-19) pandemic even among patients receiving antihypertensive treatment. This study aims to evaluate the association between equivalized annual household income and refraining from regular medical visits for hypertensive patients since the COVID-19 outbreak. We analyzed data from the Japan COVID-19 and Society Internet Survey (JACSIS), including 2832 hypertensive patients aged 20-79 years from the 2020 survey and at least one survey between 2021 and 2023. They were categorized into lower-income (<median of \3,182,000) and higher-income (≥median) groups. Refraining from regular medical visits was defined as not attending scheduled medical visits for hypertension in the past two months. Poisson regression or generalized linear mixed models were used, inverse probability weighted for Internet survey selection. After weighting, the mean age was 64.8 ± 10.3 years and 63.7% were men. In 2020, the proportion of hypertensive patients refraining from regular medical visits after weighting was 19.6% in the lower-income group and 8.8% in the higher-income group, with an adjusted proportion ratio (95% confidence interval) of 1.86 (1.13-3.06) for the lower-income group compared with the higher-income group. After 2020, the proportion of those refraining from regular medical visits declined in all income groups, and the income-related differences disappeared. During the social restrictions due to the COVID-19 pandemic, hypertensive patients with lower equivalized annual household incomes were more likely to refrain from regular medical visits. Strategies to reduce income-related inequities in medical care utilization may be necessary for future public health crises. A nationwide Internet survey in Japan revealed hypertensive patients with lower equivalized annual household incomes were significantly more likely to refrain from regular medical visits in 2020, during the social restrictions due to the COVID-19 pandemic. Addressing income-related inequities in medical care utilization is crucial for future public health crises.
Histopathological study of the localization/distribution of Fusobacterium nucleatum in esophageal cancer. 国際誌

Iku Sasaki-Higashimoto, Fumiyoshi Fujishima, Hirotaka Ishida, Yusuke Taniyama, Yohei Ozawa, Tomohiro Nakamura, Naoki Nakaya, Chiaki Sato, Hiroshi Okamoto, Junichi Tsunokake, Atsushi Kunimitsu, Takeru Mozumi, Takashi Kamei, Takashi Suzuki

Pathology international　75　(2)　82-91　2025年2月

DOI： 10.1111/pin.13505 　

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Fusobacterium nucleatum is implicated in esophageal cancer; however, its distribution in esophageal cancer tissues remains unknown. This study aimed to clarify the presence and distribution of F. nucleatum in esophageal cancer tissues using fluorescence in situ hybridization (FISH). Tissues collected from 70 patients with esophageal squamous cell carcinoma were examined using FISH. Corresponding normal epithelium and metastatic lymph nodes were assessed. F. nucleatum was identified more frequently in esophageal cancer tissues than in the normal epithelium. F. nucleatum also showed significant correlation with factors associated with tumor progression, such as pT factor and tumor size. As tumor progression advanced, the area occupied by F. nucleatum gradually became larger. F. nucleatum positivity was observed around the deep edge of the tumor nest (border-dense type) or identified diffusely in the tumor nest (diffuse distributed type). Furthermore, F. nucleatum was observed in metastatic lymph nodes, lesions of venous invasion, and walls of veins in normal epithelium. In conclusion, we visualized F. nucleatum using FISH and identified different distribution patterns of F. nucleatum, highlighting the spot density of its presence in tumor tissues. Recognizing this quantitative change is pivotal for establishing F. nucleatum as a reliable biomarker.
Association of Parity with Type 2 Diabetes Mellitus in Japan. 国際誌

Hongxin Wang, Noriyuki Iwama, Keiichi Yuwaki, You Nakamichi, Hirotaka Hamada, Hasumi Tomita, Kazuma Tagami, Rie Kudo, Natsumi Kumagai, Hirohito Metoki, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Yaegashi, Masatoshi Saito

Reproductive sciences (Thousand Oaks, Calif.)　32　(2)　366-381　2025年2月

DOI： 10.1007/s43032-024-01752-z 　

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This study investigates the association between parity and type 2 diabetes mellitus (T2DM) in Japanese women, considering the clinical history of gestational diabetes mellitus (GDM) and menopausal status, which are known risk factors for T2DM. Overall, 30,116 Japanese women (6,588 premenopausal and 23,528 postmenopausal) were included in this cross-sectional study. They were divided into two groups according to menopausal status (premenopausal and postmenopausal women), and the association between parity and T2DM was evaluated using a multiple logistic regression model with possible confounders, including a clinical history of GDM. The association between parity and T2DM was not statistically significant in premenopausal women. In contrast, a linear graded association between parity and T2DM was found in postmenopausal women. Furthermore, the association between parity and T2DM in postmenopausal women was attenuated after adjusting for body weight gain after the age of 20 years. A clinical history of GDM was significantly associated with a high risk for T2DM, regardless of adjustment for body weight gain after the age of 20 years in both premenopausal and postmenopausal women. Parity is associated with an increased risk of T2DM in postmenopausal women but not in premenopausal women. Maintaining appropriate body weight would be beneficial in attenuating the risk of T2DM in postmenopausal women. A clinical history of GDM is a risk factor for T2DM in both pre- and postmenopausal women; therefore, women with a clinical history of GDM require continuous medical care to survey for T2DM.
A Principal Component Analysis of Metabolome and Cognitive Decline Among Japanese Older Adults: Cross-sectional Analysis Using Tohoku Medical Megabank Cohort Study Data.

Sakura Kiuchi, Kumi Nakaya, Upul Cooray, Kenji Takeuchi, Ikuko N Motoike, Naoki Nakaya, Yasuyuki Taki, Seizo Koshiba, Shunji Mugikura, Ken Osaka, Atsushi Hozawa

Journal of epidemiology　35　(1)　39-46　2025年1月5日

DOI： 10.2188/jea.JE20240099 　

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BackgroundDementia is the leading cause of disability and imposes a significant burden on society. Previous studies have suggested an association between metabolites and cognitive decline. Although the metabolite composition differs between Western and Asian populations, studies targeting Asian populations remain scarce.MethodsThis cross-sectional study used data from a cohort survey of community-dwelling older adults aged ≥ 60 years living in Miyagi, Japan, conducted by Tohoku Medical Megabank Organization between 2013 and 2016. Forty-three metabolite variables quantified using nuclear magnetic resonance spectroscopy were used as explanatory variables. Dependent variable was the presence of cognitive decline (≤ 23 points), assessed by the Mini-Mental State Examination. Principal component (PC) analysis was performed to reduce the dimensionality of metabolite variables, followed by logistic regression analysis to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for cognitive decline.ResultsA total of 2,940 participants were included (men: 49.0%, mean age: 67.6 years). Among them, 1.9% showed cognitive decline. The first 12 PC components (PC1-PC12) accounted for 71.7% of the total variance. Multivariate analysis showed that PC1, which mainly represented essential amino acids, was associated with lower odds of cognitive decline (OR = 0.89; 95% CI, 0.80-0.98). PC2, which mainly included ketone bodies, was associated with cognitive decline (OR = 1.29; 95% CI, 1.11-1.51). PC3, which included amino acids, was associated with lower odds of cognitive decline (OR = 0.81; 95% CI, 0.66-0.99).ConclusionAmino acids are protectively associated with cognitive decline, whereas ketone metabolites are associated with higher odds of cognitive decline.
Genome-Wide Association Study of Intraocular Pressure in Population-Based Cohorts in Japan: The Tohoku Medical Megabank Organization Eye Study. 国際誌

Nobuo Fuse, Hayato Anzawa, Miyuki Sakurai, Ikuko N Motoike, Satoshi Nagaie, Tomohiro Nakamura, Akiko Miyazawa, Eiichi N Kodama, Masatsugu Orui, Yohei Hamanaka, Tomoko Kobayashi, Akira Uruno, Makiko Taira, Ritsuko Shimizu, Naoki Nakaya, Mami Ishikuro, Taku Obara, Fuji Nagami, Soichi Ogishima, Fumiki Katsuoka, Kazuki Kumada, Shinichi Kuriyama, Atsushi Hozawa, Yoko Izumi, Kengo Kinoshita, Masayuki Yamamoto

Ophthalmology science　5　(5)　100821-100821　2025年

DOI： 10.1016/j.xops.2025.100821 　

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PURPOSE: This study was conducted to elucidate the distribution and determinants of ocular biometric parameters and to assess the association between intraocular pressure (IOP) and single nucleotide polymorphisms (SNPs) in the Japanese population-based genome cohort studies. DESIGN: Cross-sectional analysis involving genome-wide association studies (GWASs). PARTICIPANTS: In total, 22 150 participants aged >18 years from the population cohort (Community-Based Cohort [CommCohort]) and 11 302 participants from the Birth and Three-Generation (BirThree) Cohort of the Tohoku Medical Megabank Organization Eye Study were examined. METHODS: Participant underwent interviews, ophthalmic and physiological examinations, laboratory tests, and microarray analyses. Genome-wide association studies were conducted in the CommCohort (discovery stage) and the BirThree Cohort (replication stage), followed by a meta-analysis. Associations of SNPs and IOP were evaluated using a genome-wide significance threshold (5 × 10- 8). MAIN OUTCOME MEASURES: Association of SNPs with IOP and distributions of IOP by sex and age. RESULTS: In the discovery stage, the mean IOP of the right and left eye was 13.95 and 14.02 mmHg, respectively. In the replication stage, the corresponding values were 14.32 and 14.27 mmHg, respectively. A significant age-related reduction in IOP was observed in both stages (P < 0.001). Genome-wide association studies identified 573 and 2 genome-wide significant SNPs in the discovery and replication stages, respectively. Meta-analysis revealed 1601 significant SNPs across 21 loci on 11 chromosomes (Chrs). Of these loci, 17 were previously known to be associated with IOP or glaucoma, while four-septin-8 (SEPT8; Chr5), aldehyde dehydrogenase 2 (ALDH2; Chr12), collagen type VI alpha 2 chain (COL6A2; Chr21), and Wnt family member 7B (WNT7B; Chr22)-were newly identified. CONCLUSIONS: This large-scale GWAS in a Japanese population identified 21 loci associated with IOP, including 4 novel loci. The findings highlight both genetic similarities and population-specific variations in SNPs influencing IOP and provide valuable insights to enhance eye health care, including glaucoma management. FINANCIAL DISCLOSURES: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
Has the impact of cigarette smoking on mortality been underestimated by overlooking second-hand smoke? Tohoku medical megabank community-based cohort study. 国際誌

Masato Takase, Naoki Nakaya, Kozo Tanno, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Kotaro Nochioka, Takahiro Tabuchi, Taku Obara, Mami Ishikuro, Yuka Kotozaki, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Takahito Nasu, Hideki Ohmomo, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Yoko Izumi, Atsushi Hozawa

BMJ public health　3　(1)　e001746　2025年1月

DOI： 10.1136/bmjph-2024-001746 　

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OBJECTIVES: Previous studies have assessed the impact of active smoking on mortality using the population-attributable fraction (PAF). However, these studies have not included second-hand smoking (SHS), potentially underestimating smoking's impact. We compared the PAF from active smoking alone with the PAF, including SHS exposure. DESIGN: Prospective cohort study. SETTING: A community-based cohort study in Japan. PARTICIPANTS: 40 796 participants aged ≥20 years. MAIN OUTCOME MEASURES: SHS was defined as inhaling someone else's cigarette smoke at the workplace or home in the past year. We classified smoking status and SHS into ten categories: never-smoker without SHS, never-smoker with SHS, past smoker without SHS, past smoker with SHS, current smoker 1-9 cigarettes/day without SHS, current smoker 1-9 cigarettes/day with SHS, 10-19 cigarettes/day without SHS, 10-19 cigarettes/day with SHS, ≥20 cigarettes/day without SHS and ≥20 cigarettes/day with SHS. The main outcome was all-cause mortality. RESULTS: During the median follow-up period of 6.5 (5.7-7.5) years, 788 men and 328 women died. For men, compared with never-smokers without SHS, past smokers without SHS (HR, 1.39 [95% CI, 1.11 to 1.73]) and past smokers with SHS (HR, 1.48 (95% CI, 1.10 to 2.00)) were associated with all-cause mortality. For women, never-smokers with SHS had a significantly higher risk of all-cause mortality (HR, 1.36 (95% CI, 1.00 to 1.84)). Without considering SHS, 28.0% and 2.3% of all-cause mortality in men and women, respectively, were attributable to past and current smoking. Including SHS, PAF increased to 31.3% in men and 8.4% in women. CONCLUSIONS: We clarified that smoking's impact was underestimated by not accounting for SHS, especially in women. Information on SHS is crucial for understanding smoking's health impact. This study supports the importance of avoiding smoking and preventing SHS.
Effect of Social Support on Caregiver's Functional Disability Due to Spouse's Functional Disability. 国際誌

Toshimasa Sone, Naoki Nakaya, Yumi Sugawara, Kumi Nakaya, Masayuki Hoshi, Takahiro Tabuchi, Atsushi Hozawa

Journal of the American Medical Directors Association　26　(1)　105324-105324　2025年1月

DOI： 10.1016/j.jamda.2024.105324 　

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OBJECTIVES: To examine the effect of social support on the risk of caregiver's functional disability due to spouse's functional disability. DESIGN: Longitudinal study. SETTING AND PARTICIPANTS: In this cohort study using the Ohsaki Cohort 2006 Study data, the baseline survey was conducted from December 1, 2006, to December 15, 2006, and included 7598 older adults, including 3799 couples, ≥65 years of age. METHODS: The incidence of spouse's functional disability was defined as certification for the Long-term Care Insurance, which uses a nationally uniform standard of functional disability. The primary outcome was the incidence of the caregiver's functional disability, and the follow-up period was between December 16, 2006, and November 30, 2019. Five social support questionnaires were used to assess the degree of emotional and instrumental social support available to each participant. The Cox proportional hazards model was used to evaluate the incidence of functional disability among caregivers after the occurrence of spouses' functional disability. Subgroup analyses were also conducted according to the status of emotional and instrumental social support. RESULTS: The caregiver's functional disability increased significantly among those whose spouses had functional disability compared with those whose spouses had no disability (multivariate hazard ratio [HR], 1.86). Emotional and instrumental social support showed significant positive interactions on this association (emotional and instrumental support: P for interaction < .01 and < .01, respectively), and the risk of caregiver's disability was higher among those without social support than among those with social support (with emotional support: HR, 1.84; without emotional support: HR, 2.51; with instrumental support: HR, 1.85; without instrumental support: HR, 2.31). CONCLUSIONS AND IMPLICATIONS: Social support may help to alleviate the increased risk for caregiver's functional disability due to the spouse's functional disability.
Evaluation of depression at 6 and 12 months postpartum by examining depressive symptoms and self-harm ideation during the early postpartum period: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. 国際誌

Masatsugu Orui, Taku Obara, Mami Ishikuro, Aoi Noda, Genki Shinoda, Keiko Murakami, Noriyuki Iwama, Ippei Chiba, Kumi Nakaya, Rieko Hatanaka, Mana Kogure, Natsuko Kobayashi, Saya Kikuchi, Hirohito Metoki, Masahiro Kikuya, Naoki Nakaya, Atsushi Hozawa, Hiroaki Tomita, Shinichi Kuriyama

PCN reports : psychiatry and clinical neurosciences　3　(4)　e70025　2024年12月

DOI： 10.1002/pcn5.70025 　

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AIM: The aim of this study was to evaluate depression at 6 and 12 months postpartum, using the Edinburgh Postpartum Depression Scale (EPDS) total score and its subitem regarding self-harm ideation (SHI) at 1 month postpartum. METHODS: A sample of 12,358 postpartum women answered the EPDS and questionaries at 1, 6, and 12 months postpartum longitudinally. RESULTS: For participants with postpartum depression (PPD; EPDS total score ≥9) and SHI (SHI sub-score ≥1) at 1 month postpartum, the risk of depression at 6 and 12 months postpartum (odds ratio [95% confidence interval] at 6 and 12 months postpartum: 20.03 [16.8-23.8] and 14.55 [12.3-17.2], respectively) was higher than for those with PPD but without SHI at 1 month postpartum (OR: 8.57 [7.36-10.0], and 6.24 [5.38-7.24], respectively). Additionally, SHI even without depressive symptoms at 1 month postpartum is also a risk for depression at 6 and 12 months postpartum. To support our longitudinal evaluation of depression at 6 and 12 months postpartum, these related factors were examined: traumatic events or relocations after the Great East Japan Earthquake, employment status, household income, personality traits, sleep status, psychological distress, and social networks. The result showed employment status, low household income and poor social networks were significantly associated with depression at 12 months postpartum but not at 6 months postpartum. CONCLUSION: This study showed a high risk of depression at 6 and 12 months postpartum for those who had depressive symptoms with SHI at 1 month postpartum. Our findings may contribute to the precise evaluation of depression at 6 and 12 months postpartum while considering sleep status, psychological distress and social network during pregnancy.
Genetic Risk, Healthy Lifestyle Adherence, and Risk of Developing Diabetes in the Japanese Population.

Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Akira Narita, Taku Obara, Mami Ishikuro, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Koichi Matsuda, Yoko Izumi, Kengo Kinoshita, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

Journal of atherosclerosis and thrombosis　31　(12)　1717-1732　2024年12月1日

DOI： 10.5551/jat.64906 　

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AIM: This study examined the relationship between genetic risk, healthy lifestyle, and risk of developing diabetes. METHODS: This prospective cohort study included 11,014 diabetes-free individuals ≥ 20 years old from the Tohoku Medical Megabank Community-based cohort study. Lifestyle scores, including the body mass index, smoking, physical activity, and gamma-glutamyl transferase (marker of alcohol consumption), were assigned, and participants were categorized into ideal, intermediate, and poor lifestyles. A polygenic risk score (PRS) was constructed based on the type 2 diabetes loci from the BioBank Japan study. A multiple logistic regression model was used to estimate the association between genetic risk, healthy lifestyle, and diabetes incidence and to calculate the area under the receiver operating characteristic curve (AUROC). RESULT: Of the 11,014 adults included (67.8% women; mean age [standard deviation], 59.1 [11.3] years old), 297 (2.7%) developed diabetes during a mean 4.3 (0.8) years of follow-up. Genetic and lifestyle score is independently associated with the development of diabetes. Compared with the low genetic risk and ideal lifestyle groups, the odds ratio was 3.31 for the low genetic risk and poor lifestyle group. When the PRS was integrated into a model including the lifestyle and family history, the AUROC significantly improved to 0.719 (95% confidence interval [95% CI]: 0.692-0.747) compared to a model including only the lifestyle and family history (0.703 [95% CI, 0.674-0.732]). CONCLUSION: Our findings indicate that adherence to a healthy lifestyle is important for preventing diabetes, regardless of genetic risk. In addition, genetic risk might provide information beyond lifestyle and family history to stratify individuals at high risk of developing diabetes.
Awareness, information sources, and beliefs regarding palliative care in the general population in Japan: a nationwide cross-sectional survey (INFORM study 2023). 国際誌

Yu Uneno, Masanori Mori, Junko Saito, Aki Otsuki, Aya Kuchiba, Naomi Sakurai, Naoki Nakaya, Maiko Fujimori, Taichi Shimazu

Japanese journal of clinical oncology　54　(11)　1171-1179　2024年11月2日
出版者・発行元： Oxford University Press (OUP)
DOI： 10.1093/jjco/hyae092 　

eISSN：1465-3621

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Abstract Background The diversification of information sources and changes in social structures necessitates updates on the state of public awareness of palliative care. Therefore, we clarified the status and determinants of awareness, information sources, and beliefs, regarding palliative care in Japan. Methods This nationwide cross-sectional survey included 10 000 participants aged ≥20 years enrolled through random sampling using a two-stage stratification in 2023. We used a mailed self-administered questionnaire (INFORM Study 2023). The questionnaire items were selected (partially modified) from the Health Information National Trends Survey (USA) to ensure comparability, included palliative care awareness, information sources, and beliefs. Weighted logistic regression was conducted to explore the determinants of awareness. Results Of the 3452 participants that responded (response rate: 35.3%), 65.2% had palliative care awareness. The weighted logistic regression analysis revealed that respondents less likely to have any palliative care awareness were younger, were male, had limited education history, had lower household income, and were non-Internet users. Of these, sex had the clear association (adjusted odds ratio for female vs. male: 3.20 [95% CI: 2.66–3.85]). Across all age groups, healthcare professionals (58.5%) and the Internet (30.5%) were the most trusted source of information. Younger participants frequently received information online. Most participants believed that palliative care was beneficial, although 82.0% associated it with death. Conclusions The Japanese population had a relatively high palliative care awareness, with the majority trusting information from healthcare professionals rather than the Internet. Further efforts are warranted to address barriers to receiving trustworthy palliative care information.
The association of birth weight and current BMI on the risk of hypertension: the Tohoku medical megabank community-based cohort study. 国際誌

Hiromi Himuro, Mana Kogure, Naoki Nakaya, Tomohiro Nakamura, Rieko Hatanaka, Ippei Chiba, Kumi Nakaya, Naho Tsuchiya, Takumi Hirata, Masatsugu Orui, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Akira Uruno, Nobuo Fuse, Satoshi Nagaie, Soichi Ogishima, Mami Ishikuro, Taku Obara, Yoko Izumi, Masatoshi Saito, Shinichi Kuriyama, Atsushi Hozawa, Junichi Sugawara

Hypertension research : official journal of the Japanese Society of Hypertension　47　(11)　3025-3034　2024年11月

DOI： 10.1038/s41440-024-01827-z 　

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This study aimed to investigate the association of combination of birth weight and current body mass index (BMI) with the risk of hypertension in adulthood. This cross-sectional study used data from the Tohoku Medical Megabank Community-based Cohort Study conducted in Japan. A total of 10,688 subjects aged ≥20 years were eligible. We calculated the least square (LS) means of systolic blood pressure (SBP) and trend tests were performed to evaluate the linear relationships between birth weight categories and SBP. We also used a multivariate logistic regression analysis to assess the risk of hypertension associated with the combination of birth weight and current BMI. There was a statistically inverse association between birth weight and SBP in the 20-64 age group, but no significant association in the ≥65 age group. Low birth weight (LBW) with normal BMI group had a higher risk of hypertension than the normal or high birth weight groups with normal BMI. Furthermore, the group with LBW and BMI ≥25.0 kg/m2 was the highest risk for hypertension (adjusted odds ratio: 2.73; 95% CI, 2.04-3.65) compared to the reference group (birth weight 2500-3499 g and BMI 18.5-24.9 kg/m2). There was a significant association between LBW and subsequent risk of hypertension. In addition, participants with lower birth weights had a higher risk of hypertension than those with higher birth weights. However, even in participants with a lower birth weight, the risk of hypertension could be reduced when they maintained an optimal BMI.
Depressive symptoms as risk factors for the onset of home hypertension: a prospective cohort study. 国際誌

Sayuri Tokioka, Naoki Nakaya, Rieko Hatanaka, Kumi Nakaya, Mana Kogure, Ippei Chiba, Kotaro Nochioka, Hirohito Metoki, Takahisa Murakami, Michihiro Satoh, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　47　(11)　2989-3000　2024年11月

DOI： 10.1038/s41440-024-01790-9 　

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Depression is comorbid with somatic diseases; however, the relationship between depressive symptoms and hypertension (HT), a risk factor for cardiovascular events, remains unclear. Home blood pressure (BP) is more reproducible and accurately predictive of cardiovascular diseases than office BP. Therefore, we focused on home BP and investigated whether depressive symptoms contributed to the future onset of home HT. This prospective cohort study used data from the Tohoku Medical Megabank Community-Cohort Study (conducted in the Miyagi Prefecture, Japan) and included participants with home normotension (systolic blood pressure (SBP) < 135 mmHg and diastolic blood pressure (DBP) < 85 mmHg). Depressive symptoms were evaluated using the Center for Epidemiologic Studies Depression Scale-Japanese version at the baseline survey. In the secondary survey, approximately 4 years later, the onset of home HT was evaluated (SBP ≥ 135 mmHg or DBP ≥ 85 mmHg) and was compared in participants with and without depressive symptoms. Of the 3 082 (mean age: 54.2 years; females: 80.9%) participants, 729 (23.7%) had depressive symptoms at the baseline survey. During the 3.5-year follow-up, 124 (17.0%) and 388 (16.5%) participants with and without depressive symptoms, respectively, developed home HT. Multivariable adjusted odds ratios were 1.37 (95% confidence interval (CI): 1.02-1.84), 1.18 (95% CI: 0.86-1.61), and 1.66 (95% CI: 1.17-2.36) for home, morning, and evening HT, respectively. This relationship was consistent in the subgroup analyses according to age, sex, BP pattern, and drinking habit. Depressive symptoms increased the risk of new-onset home HT, particularly evening HT, among individuals with home normotension. This prospective cohort study revealed that depressive symptoms are risk factors for new-onset home hypertension, particularly evening hypertension among individuals with home normotension. Assessing home blood pressure in individuals with depressive symptoms is important for the prevention of hypertension and concomitant cardiovascular diseases.
Risk factors and pattern of metastatic recurrence after endoscopic resection with additional treatment for esophageal cancer. 国際誌

Ippei Tanaka, Waku Hatta, Tomoyuki Koike, So Takahashi, Tomohiro Shimada, Takuto Hikichi, Yosuke Toya, Yusuke Onozato, Koichi Hamada, Daisuke Fukushi, Ko Watanabe, Shoichi Kayaba, Hirotaka Ito, Tetsuya Tatsuta, Tomoyuki Oikawa, Yasushi Takahashi, Yutaka Kondo, Tetsuro Yoshimura, Takeharu Shiroki, Ko Nagino, Norihiro Hanabata, Akira Funakubo, Tetsuya Ohira, Jun Nakamura, Tomohiro Nakamura, Naoki Nakaya, Katsunori Iijima, Takayuki Matsumoto, Shinsaku Fukuda, Atsushi Masamune, Dai Hirasawa

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus　37　(11)　2024年10月28日

DOI： 10.1093/dote/doae048 　

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Although esophageal cancers invading the muscularis mucosa (pT1a-MM) or submucosa (pT1b-SM) after endoscopic resection (ER) are associated with a risk of lymph node metastasis, details of metastatic recurrence after additional treatment remain unknown. We aimed to identify the risk factors for metastatic recurrence and recurrence patterns in patients receiving additional treatment after ER for esophageal cancer. Between 2006 and 2017, patients with pT1a-MM/pT1b-SM esophageal cancer who underwent ER with additional treatment (esophagectomy, chemoradiotherapy [CRT], and radiation therapy) at 21 institutions in Japan were enrolled. We evaluated the risk factors for metastatic recurrence after ER with additional treatment. Subsequently, the rate and pattern (locoregional or distant) of metastatic recurrence were investigated for each additional treatment. Of the 220 patients who received additional treatment, 57, 125, and 38 underwent esophagectomy, CRT, and radiation therapy, respectively. In the multivariate analysis, lymphatic invasion was the sole risk factor for metastatic recurrence after additional treatment (hazard ratio, 3.50; P = 0.029). Although the risk of metastatic recurrence with additional esophagectomy was similar to that with CRT (hazard ratio, 1.01; P = 0.986), the rate of locoregional recurrence tended to be higher with additional esophagectomy (80.0% (4/5) vs. 36.4% (4/11)), leading to a better prognosis in patients with metastatic recurrence after additional esophagectomy than CRT (survival rate, 80.0% (4/5) vs. 9.1% (1/11)). Patients with lymphatic invasion have a high risk of metastatic recurrence after ER with additional treatment for pT1a-MM/pT1b-SM esophageal cancer. Additional esophagectomy may result in a better prognosis after metastatic recurrence.
Associations between leisure time, non-leisure time physical activity, and kidney function in Japanese adults: a cross-sectional study. 国際誌

Ippei Chiba, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Sayuri Tokioka, Tomohiro Nakamura, Satoshi Nagaie, Soichi Ogishima, Taku Obara, Toshimi Sato, Nobuo Fuse, Yoko Izumi, Shinichi Kuriyama, Atsushi Hozawa

BMC nephrology　25　(1)　354-354　2024年10月16日

DOI： 10.1186/s12882-024-03813-6 　

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BACKGROUND: Chronic kidney disease (CKD) contributes to decreased life expectancy. We examined the association between leisure-time physical activity (LTPA), non-leisure-time physical activity (non-LTPA) and kidney function. METHODS: This was a cross-sectional study including 32 162 community-dwelling adults aged ≥ 20 years from the Tohoku Medical MegaBank community-based cohort study. Kidney function was evaluated using cystatin C-based estimated glomerular filtration rate (eGFR) as well as self-reported LTPA and non-LTPA. CKD was defined as either eGFR decline (≤ 60 mL/min/1.73 m2) or presence of albuminuria (albumin-creatinine ≥ 30 mg/g). The association between domain-specific physical activity and kidney function, and CKD prevalence was examined using multivariable-adjusted ordinary least squares and modified Poisson models. RESULTS: The mean eGFR was 98.1 (± 13.2) mL/min/1.73 m2. 3 185 (9.9%) participants were classified as having CKD. The mean LTPA and non-LTPA levels were 2.9 (± 4.2) and 16.6 (± 14.2) METs-hour/day, respectively. For LTPA, in the adjusted model, the quartile groups with higher levels had a higher kidney function (β, 0.36; 95% confidence intervals [CI], [0.06, 0.66]; p = 0.019 for the 2nd quartile, β, 0.82; 95% CI, [0.51, 1.14]; p < 0.001 for the 3rd quartile, and β, 1.16; 95% CI, [0.83, 1.49]; p < 0.001 for the 4th quartile), whereas there were no apparent associations for prevalence of CKD. For non-LTPA, 4th quartile was associated with decreased eGFR (β, -0.42; 95% CI, [-0.72, -0.11]; p = 0.007) and higher prevalence of CKD prevalence (Prevalence ratio, 1.12; 95% CI, [1.02, 1.24]; p = 0.022). These associations with kidney function remained consistent in the subgroup analyses divided by demographic and biological variables. CONCLUSIONS: We observed a positive association between higher LTPA levels and better kidney function, but not association with CKD prevalence. In contrast, higher non-LTPA was negatively associated with both kidney function and CKD prevalence. These findings suggest that promoting LTPA is beneficial for kidney function.
喫煙歴と受動喫煙の組み合わせと総死亡の関連

高瀬雅仁, 高瀬雅仁, 中谷直樹, 中谷直樹, 丹野高三, 小暮真奈, 小暮真奈, 畑中里衣子, 畑中里衣子, 中谷久美, 中谷久美, 千葉一平, 千葉一平, 時岡紗由理, 時岡紗由理, 永家聖, 永家聖, 事崎由佳, 大桃秀樹, 田淵貴大, 田淵貴大, 寳澤篤, 寳澤篤

日本公衆衛生学会総会抄録集(CD-ROM)　83rd　265-265　2024年10月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
独居と総死亡の関連:東北メディカル・メガバンク地域住民コホート調査

事崎由佳, 中谷久美, 中谷直樹, 小暮真奈, 千葉一平, 畑中里衣子, 高瀬雅仁, 時岡紗由理, 永家聖, 大桃秀樹, 寶澤篤, 丹野高三

日本公衆衛生学会総会抄録集(CD-ROM)　83rd　362-362　2024年10月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
Comparison of renal prognosis between dipeptidyl peptidase-4 inhibitor users and non-users. 国際誌

Hideaki Hashimoto, Michihiro Satoh, Shingo Nakayama, Maya Toyama, Takahisa Murakami, Taku Obara, Naoki Nakaya, Takefumi Mori, Atushi Hozawa, Hirohito Metoki

Diabetes, obesity & metabolism　26　(10)　4460-4467　2024年10月

DOI： 10.1111/dom.15800 　

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AIM: To evaluate the renal prognosis of dipeptidyl peptidase-4 inhibitor (DPP-4i) users and non-users using real-world Asian data. METHODS: Using databases from DeSC Healthcare, Inc., patients aged 30 years or older who used antidiabetic drugs from 2014 to 2021 were identified. Propensity score matching analyses were used to compare renal prognosis between DPP-4i users and non-users. The primary outcomes were estimated glomerular filtration rate (eGFR) decline and end-stage kidney disease (ESKD) development in the eGFR of 45 mL/min/1.73m2 or higher and eGFR of less than 45 mL/min/1.73m2 groups, respectively. RESULTS: In total, 65 375 and 9866 patients were identified in the eGFR of 45 mL/min/1.73m2 or higher and eGFR of less than 45 mL/min/1.73m2 groups, respectively. In the eGFR of 45 mL/min/1.73m2 or higher group, propensity score matching created 16 002 pairs. A significant difference was observed in the primary outcome of eGFR decline between DPP-4i users and non-users at 2 years (-2.31 vs. -2.56 mL/min/1.73m2: difference, 0.25 mL/min/1.73m2; 95% confidence interval [CI], 0.06-0.44) and 3 years (-2.75 vs. -3.41 mL/min/1.73m2: difference, 0.66 mL/min/1.73m2; 95% CI, 0.39-0.93). In the eGFR less than 45 mL/min/1.73m2 group, propensity score matching created 2086 pairs. After a mean of 2.2 years of observation, ESKD development was 1.15% and 2.30% in users and non-users, respectively, and Kaplan-Meier analysis revealed a significant difference (log rank P = .005). CONCLUSIONS: This retrospective real-world study revealed that patients using DPP-4is had a better renal prognosis than those not using DPP-4is.
Is blue light imaging without magnification satisfactory as screening for esophageal squamous cell carcinoma? Post-hoc analysis of multicenter randomized controlled trial. 国際誌

Yohei Ogata, Waku Hatta, Tomoyuki Koike, So Takahashi, Tamotsu Matsuhashi, Wataru Iwai, Sho Asonuma, Hideki Okata, Motoki Ohyauchi, Hirotaka Ito, Yasuhiko Abe, Yu Sasaki, Masashi Kawamura, Masahiro Saito, Kaname Uno, Fumiyoshi Fujishima, Tomohiro Nakamura, Naoki Nakaya, Katsunori Iijima, Atsushi Masamune

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society　36　(10)　1118-1126　2024年10月

DOI： 10.1111/den.14788 　

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OBJECTIVES: Narrow light observation is currently recommended as an alternative to Lugol chromoendoscopy (LCE) to detect esophageal squamous cell carcinoma (ESCC). Studies revealed little difference in sensitivity between the two modalities in expert settings; however, these included small numbers of cases. We aimed to determine whether blue light imaging (BLI) without magnification is satisfactory for preventing misses of ESCC. METHODS: This was a post-hoc analysis of a multicenter randomized controlled trial targeting patients at high risk of ESCC in expert settings. In this study, BLI without magnification followed by LCE was performed. The evaluation parameters included: (i) the diagnostic abilities of ESCC; (ii) the endoscopic characteristics of lesions with diagnostic differences between the two modalities; and (iii) the color difference between cancerous and noncancerous areas in BLI and LCE. RESULTS: This study identified ESCC in 49 of 699 cases. Of these cases, nine (18.4%) were missed by BLI but detected by LCE. In per-patient analysis, the sensitivity of BLI was lower than that of LCE following BLI (83.7% vs. 100.0%; P = 0.013), whereas the specificity and accuracy of BLI were higher (88.2% vs. 81.2%; P < 0.001 and 87.8% vs. 82.5%; P < 0.001, respectively). No significant endoscopic characteristics were identified, but the color difference was lower in BLI than in LCE (21.4 vs. 25.1; P = 0.003). CONCLUSION: LCE following BLI outperformed BLI in terms of sensitivity in patients with high-risk ESCC. Therefore, LCE, in addition to BLI, would still be required in screening esophagogastroduodenoscopy even by expert endoscopists.
Progress Report of the Tohoku Medical Megabank Community-based Cohort Study: Study Profile of the Repeated Center-based Survey During Second Period in Miyagi Prefecture.

Atsushi Hozawa, Kumi Nakaya, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Junichi Sugawara, Eiichi Kodama, Yohei Hamanaka, Tomoko Kobayashi, Akira Uruno, Naho Tsuchiya, Takumi Hirata, Akira Narita, Akito Tsuboi, Toru Tamahara, Akihito Otsuki, Maki Goto, Makiko Taira, Ritsuko Shimizu, Kichiya Suzuki, Taku Obara, Masahiro Kikuya, Hirohito Metoki, Mami Ishikuro, Inaho Danjoh, Soichi Ogishima, Satoshi Nagaie, Naoko Minegishi, Masahiro Hiratsuka, Kazuki Kumada, Ichiko Nishijima, Takahiro Nobukuni, Yumi Yamaguchi-Kabata, Fuji Nagami, Shigeo Kure, Nobuo Fuse, Kengo Kinoshita, Yoko Izumi, Shinichi Kuriyama, Masayuki Yamamoto

Journal of epidemiology　34　(9)　434-443　2024年9月5日

DOI： 10.2188/jea.JE20230241 　

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BACKGROUND: The purpose of this study was to report the basic profile of the Miyagi Prefecture part of a repeated center-based survey during the second period (2nd period survey) of the Tohoku Medical Megabank Community-Based Cohort Study (TMM CommCohort Study), as well as the participants' characteristics based on their participation type in the baseline survey. METHODS: The 2nd period survey, conducted from June 2017 to March 2021, included participants of the TMM CommCohort Study (May 2013 to March 2016). In addition to the questionnaire, blood, urine, and physiological function tests were performed during the 2nd period survey. There were three main ways of participation in the baseline survey: Type 1, Type 1 additional, or Type 2 survey. The 2nd period survey was conducted in the same manner as the Type 2 survey, which was based on the community support center (CSC). RESULTS: In Miyagi Prefecture, 29,383 (57.7%) of 50,967 participants participated in the 2nd period survey. The participation rate among individuals who had visited the CSC was approximately 80%. Although some factors differed depending on the participation type in the baseline survey, the 2nd period survey respondents in the Type 1 and Type 2 survey groups at baseline had similar traits. CONCLUSIONS: The 2nd period survey of the TMM CommCohort Study provided detailed follow-up information. Following up on the health conditions of the participants will clarify the long-term effects of disasters and contribute to personalized prevention.
Birth Weight and Labor Market Outcomes: Findings From Tohoku Medical Megabank Data. 国際誌

Midori Matsushima, Taku Obara, Mami Ishikuro, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama

Public health challenges　3　(3)　e221　2024年9月

DOI： 10.1002/puh2.221 　

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BACKGROUND: Epidemiological and economic literature has revealed that low birth weight (LBW) is related to poor health conditions and a broader range of negative socio-economic outcomes, including academic achievement, income levels, and working status. However, Japanese evidence for labor outcomes is particularly lacking, as is the question of whether the impact of LBW on adulthood worsens when disasters occur. We aimed to reveal the impact on LBW on labor outcomes during the disaster recovery phase. METHODS: We used a cross-sectional data set of 4156 national health insurance holders, males aged 40-60 years, from the Miyagi and Iwate prefectures during the earthquake recovery phase. Employing a multinomial probit and logistic model, we estimated the impact of LBW on the employment status, changes in income, and the propensity to face a decline in income with a job change. RESULTS: The very low birth weights (VLBWs) have a disadvantage in all labor market outcomes. Compared to the non-LBWs, the VLBWs were 15.2% less likely to be full-time/self-employed and 17.1% more likely to be contingent/temporary/part-time workers. Moreover, 32.9% are more likely to face a decline in income and approximately 3.7 times more likely to change jobs leading to income decline. The LBWs were likely to face a decline in income by 8.6% and 4.6%, respectively, but no other significant effects were found on other outcomes. CONCLUSIONS: The effects were apparent for the VLBW, but not so much for the LBW. The effects became larger during the disaster recovery phase, even though the regional economies were boosted.
Association of olfactory and cognitive function test scores with hippocampal and amygdalar grey matter volume: a cross-sectional study. 国際誌

Shuichi Sato, Takao Imaeda, Shunji Mugikura, Naoko Mori, Masaki Takanashi, Kazumi Hayakawa, Tomo Saito, Makiko Taira, Akira Narita, Mana Kogure, Ippei Chiba, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Ryosuke Ishiwata, Tomohiro Nakamura, Ikuko N Motoike, Naoki Nakaya, Seizo Koshiba, Kengo Kinoshita, Shinichi Kuriyama, Soichi Ogishima, Fuji Nagami, Nobuo Fuse, Atsushi Hozawa

Scientific reports　14　(1)　19138-19138　2024年8月19日

DOI： 10.1038/s41598-024-69726-4 　

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Few population-based studies including younger adults have examined the potential of olfactory function tests to capture the degree of atrophy in memory-associated brain regions, which cannot be adequately explained by cognitive function tests screening for cognitive impairment. This population-based study investigated associations between high-resolution olfactory test data with few odours and grey matter volumes (GMVs) of the left and right hippocampi, amygdala, parahippocampi, and olfactory cortex, while accounting for differences in cognitive decline, in 1444 participants (aged 31-91 years). Regression analyses included intracranial volume (ICV)-normalised GMVs of eight memory-related regions as objective variables and age, sex, education duration, smoking history, olfaction test score, and the Montreal Cognitive Assessment-Japanese version (MoCA-J) score as explanatory variables. Significant relationships were found between olfactory test scores and ICV-normalised GMVs of the left and right hippocampi and left amygdala (p = 0.020, 0.024, and 0.028, respectively), adjusting for the MoCA-J score. The olfactory test score was significantly related to the right amygdalar GMV (p = 0.020) in older adults (age ≥ 65 years). These associations remained significant after applying Benjamini-Hochberg multiple testing correction (false discovery rate < 0.1). Therefore, olfactory and cognitive function tests may efficiently capture the degree of atrophy in the hippocampi and amygdala, especially in older adults.
Associations of combined genetic and lifestyle risks with hypertension and home hypertension. 国際誌

Masato Takase, Takumi Hirata, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Akira Narita, Hirohito Metoki, Michihiro Satoh, Taku Obara, Mami Ishikuro, Hisashi Ohseto, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

Hypertension research : official journal of the Japanese Society of Hypertension　47　(8)　2064-2074　2024年8月

DOI： 10.1038/s41440-024-01705-8 　

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No study, to our knowledge, has constructed a polygenic risk score based on clinical blood pressure and investigated the association of genetic and lifestyle risks with home hypertension. We examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. In a cross-sectional study of 7027 Japanese individuals aged ≥20 years, we developed a lifestyle score based on body mass index, alcohol consumption, physical activity, and sodium-to-potassium ratio, categorized into ideal, intermediate, and poor lifestyles. A polygenic risk score was constructed with the target data (n = 1405) using publicly available genome-wide association study summary statistics from BioBank Japan. Using the test data (n = 5622), we evaluated polygenic risk score performance and examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. Hypertension and home hypertension were defined as blood pressure measured at a community-support center ≥140/90 mmHg or at home ≥135/85 mmHg, respectively, or self-reported treatment for hypertension. In the test data, 2294 and 2322 participants had hypertension and home hypertension, respectively. Both polygenic risk and lifestyle scores were independently associated with hypertension and home hypertension. Compared with those of participants with low genetic risk and an ideal lifestyle, the odds ratios for hypertension and home hypertension in the low genetic risk and poor lifestyle group were 1.94 (95% confidence interval, 1.34-2.80) and 2.15 (1.60-2.90), respectively. In summary, lifestyle is important to prevent hypertension; nevertheless, participants with high genetic risk should carefully monitor their blood pressure despite a healthy lifestyle.
Risk stratification of synchronous gastric cancers including alcohol-related genetic polymorphisms. 国際誌

Sho Asonuma, Waku Hatta, Tomoyuki Koike, Hideki Okata, Kaname Uno, Wataru Iwai, Masashi Saito, Makoto Yonechi, Daisuke Fukushi, Shoichi Kayaba, Ryosuke Kikuchi, Hirotaka Ito, Jun Fushiya, Ryuhei Maejima, Yasuhiko Abe, Masashi Kawamura, Junya Honda, Yutaka Kondo, Naohiro Dairaku, Shusuke Toda, Kenta Watanabe, Kiichi Takahashi, Hiroharu Echigo, Yasuaki Abe, Hiroyuki Endo, Tomoki Okata, Tatsuya Hoshi, Kenji Kinoshita, Madoka Kisoi, Tomohiro Nakamura, Naoki Nakaya, Katsunori Iijima, Atsushi Masamune

Journal of gastroenterology and hepatology　39　(8)　1554-1562　2024年8月

DOI： 10.1111/jgh.16570 　

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BACKGROUND AND AIM: We previously identified that ever-smoking and severe gastric atrophy in pepsinogen are risk factors for synchronous gastric cancers (SGCs). This study aimed to determine the association of alcohol drinking status or alcohol-related genetic polymorphism with SGCs and also stratify their risk. METHODS: This multi-center prospective cohort study included patients who underwent endoscopic submucosal dissection for the initial early gastric cancers at 22 institutions in Japan. We evaluated the association of alcohol drinking status or alcohol dehydrogenase 1B (ADH1B) and acetaldehyde dehydrogenase 2 (ALDH2) genotypes with SGCs. We then stratified the risk of SGCs by combining prespecified two factors and risk factors identified in this study. RESULTS: Among 802 patients, 130 had SGCs. Both the ADH1B Arg and ALDH2 Lys alleles demonstrated a significant association with SGCs on multivariate analysis (odds ratio, 1.77), although alcohol drinking status showed no association. The rates of SGCs in 0-3 risk factors in the combined evaluation of three risk factors (ever-smoking, severe gastric atrophy in pepsinogen, and both the ADH1B Arg and ALDH2 Lys alleles) were 7.6%, 15.0%, 22.0%, and 32.1%, respectively. The risk significantly increased from 0 to 3 risk factors on multivariate analysis (P for trend <0.001). CONCLUSIONS: Both the ADH1B Arg and ALDH2 Lys alleles were at high risk for SGCs. The risk stratification by these three factors may be a less invasive and promising tool for predicting their risk.
Fractional exhaled nitric oxide distribution and its relevant factors in the general adult population and its healthy subpopulation. 国際誌

Mitsuhiro Yamada, Masato Takase, Kumi Nakaya, Tomohiro Nakamura, Mana Kogure, Naoki Nakaya, Naoya Fujino, Tsutomu Tamada, Chikashi Iwasaki, Manami Suzuki, Shuichiro Matsumoto, Nobuo Fuse, Akira Uruno, Kazuki Kumada, Soichi Ogishima, Shinichi Kuriyama, Masakazu Ichinose, Hisatoshi Sugiura, Atsushi Hozawa

The journal of allergy and clinical immunology. Global　3　(3)　100253-100253　2024年8月

DOI： 10.1016/j.jacig.2024.100253 　

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BACKGROUND: Measurement of fractional exhaled nitric oxide (Feno) has been used in the diagnosis and management of asthma. Understanding the distribution of Feno in a larger resident population and its "healthy" subpopulation would contribute to the interpretation of Feno in clinical practice. OBJECTIVE: This study aimed to investigate the distribution and its associated factors in the adult population and its healthy subpopulations. METHODS: We conducted a cross-sectional study of 8,638 men and 17,288 women aged 20 years or older living in Miyagi prefecture, Japan. We investigated the distribution of Feno and its associated factors in all subjects, a subpopulation with no history of upper and lower airway diseases (healthy subpopulation 1), and a subpopulation with no history of upper and lower airway diseases, normal lung function, and no positivity for other biomarkers of type 2 inflammation (healthy subpopulation 2). RESULTS: The distribution of Feno in healthy subpopulations, especially in healthy subpopulation 2 (median [interquartile range], 17 [12-23] with 95th percentile of 36 ppb) was lower than in all subjects (19 [13-26] ppb with 95th percentile of 47 ppb). In healthy subpopulation 1, 10.3% had elevated Feno (≥35 ppb), and elevated Feno was positively associated with factors including obstructive ventilatory defect, blood eosinophilia, house dust mite-specific IgE positivity, and history of hypertension. Male sex was associated with elevated Feno in all subjects and healthy subpopulations. CONCLUSION: The distribution of Feno in the healthy subpopulation supports the validity of the criteria (≥35 ppb) currently used in Japan for the diagnosis of asthma.
How Healthy Lifestyle Habits Have Interacted with SARS-CoV-2 Infection and the Effectiveness of COVID-19 Vaccinations: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

Masatsugu Orui, Taku Obara, Mami Ishikuro, Aoi Noda, Genki Shinoda, Keiko Murakami, Tomohiro Nakamura, Hirohito Metoki, Soichi Ogishima, Yoko Izumi, Naoki Nakaya, Atsushi Hozawa, Tadashi Ishii, Fuji Nagami, Masayuki Yamamoto, Shinichi Kuriyama

JMA journal　7　(3)　353-363　2024年7月16日

DOI： 10.31662/jmaj.2024-0043 　

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INTRODUCTION: To examine the interaction between lifestyle habits and the COVID-19 vaccinations for preventing SARS-CoV-2 infection, we analyzed 11,016 adult participants registered in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. METHODS: Lifestyle variables, including regular exercise, smoking and drinking habits, sleep status, body mass index, and daily breakfast consumption, were assessed from 2014 to 2019 using baseline questionnaires. Information on SARS-CoV-2 infection and the COVID-19 vaccination were also collected from March 2020 to May 2023. The study period was divided into two in the postvaccination phase: the first period (the beginning of the vaccination program) and the second period (the fourth shot onward). RESULTS: In the Cox proportional-hazards model analysis, the five-time vaccinations group showed a significantly lower risk of SARS-CoV-2 infection adjusted age, sex, underlying health condition, and lifestyle variables (hazard ratio [HR] 0.81, 95% confidence interval [CI] 0.76-0.86). Logistic regression analysis revealed that a higher number of vaccinations was significantly associated with a low risk of SARS-CoV-2 infection regardless of lifestyle habits (three times in the first period: odds ratio [OR] 0.19, 95% CI 0.15-0.24; five times in the second period: OR 0.07, 95% CI 0.05-0.11 vs. none). Regarding lifestyle habits, the risk reduction in those who had sleep satisfaction (OR 0.12, 95% CI 0.08-0.18) was slightly larger than in those who had sleep dissatisfaction (OR 0.23, 95% CI 0.17-0.32) in the group with the highest number of vaccinations in the first period; however, this interaction was hardly confirmed in the second period when the number of infected cases significantly increased. CONCLUSIONS: Our findings indicated that a higher number of COVID-19 vaccinations was associated with reduced risk of SARS-CoV-2 infection; otherwise, we may need to understand the advantages and limitations of a healthy lifestyle for preventing infection depending on the situation with vaccinations and infection spreading.
Identifying critical age and gender-based metabolomic shifts in a Japanese population of the Tohoku Medical Megabank cohort. 国際誌

Miyuki Sakurai, Ikuko N Motoike, Eiji Hishinuma, Yuichi Aoki, Shu Tadaka, Mana Kogure, Masatsugu Orui, Mami Ishikuro, Taku Obara, Naoki Nakaya, Kazuki Kumada, Atsushi Hozawa, Shinichi Kuriyama, Masayuki Yamamoto, Seizo Koshiba, Kengo Kinoshita

Scientific reports　14　(1)　15681-15681　2024年7月8日

DOI： 10.1038/s41598-024-66180-0 　

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Understanding the physiological changes associated with aging and the associated disease risks is essential to establish biomarkers as indicators of biological aging. This study used the NMR-measured plasma metabolome to calculate age-specific metabolite indices. In doing so, the scope of the study was deliberately simplified to capture general trends and insights into age-related changes in metabolic patterns. In addition, changes in metabolite concentrations with age were examined in detail, with the period from 55-59 to 60-64 years being a period of significant metabolic change, particularly in men, and from 45-49 to 50-54 years in females. These results illustrate the different variations in metabolite concentrations by sex and provide new insights into the relationship between age and metabolic diseases.
独居・同居と婚姻状態の組み合わせと総死亡の関連:東北メディカル・メガバンク地域住民コホート調査

事崎由佳, 中谷久美, 中谷直樹, 小暮真奈, 千葉一平, 畑中里衣子, 高瀬雅仁, 時岡紗由理, 永家聖, 那須崇人, 大桃秀樹, 寳澤篤, 丹野高三

東北公衆衛生学会講演集　73rd (CD-ROM)　(73)　23-23　2024年7月
出版者・発行元：東北公衆衛生学会
ISSN：0915-549X
Combined effects of blood pressure and glucose status on the risk of chronic kidney disease. 国際誌

Maya Toyama, Michihiro Satoh, Shingo Nakayama, Hideaki Hashimoto, Tomoko Muroya, Takahisa Murakami, Takuo Hirose, Taku Obara, Naoki Nakaya, Takefumi Mori, Takayoshi Ohkubo, Yutaka Imai, Atsushi Hozawa, Hirohito Metoki

Hypertension research : official journal of the Japanese Society of Hypertension　47　(7)　1831-1841　2024年7月

DOI： 10.1038/s41440-024-01683-x 　

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This study aimed to assess the combined effects of blood pressure (BP) and glucose status on chronic kidney disease (CKD) incidence in young and middle-aged adults. We examined data from 1,297,341 Japanese individuals aged <60 years (60.1% men; mean age 41.4 ± 9.3 years) with no history of CKD at baseline. The interval-censored Cox proportional hazards model with covariates was used. During a median follow-up period of 2.1 years, new onset CKD (estimated glomerular filtration rate <60 ml/min/1.73 m2 and/or proteinuria) occurred in 80,187 participants. In participants without antihypertensive treatment (AHT), the adjusted hazard ratios (95% confidence interval) per 1-standard deviation, that is, 15 mmHg increase in systolic BP for CKD incidence, were 1.08 (1.07-1.09), 1.12 (1.10-1.13), and 1.15 (1.12-1.18) in normoglycemia, borderline glycemia, and diabetes groups, respectively. These ratios were significantly higher in the borderline glycemia and diabetes groups compared with those in the normoglycemia group (interaction p < 0.0001). The interaction between BP and borderline glycemia was evident when the outcome definition was restricted to proteinuria. In participants under AHT, systolic BP was most strongly associated with CKD risk in the diabetes group, although no significant interaction was observed. High BP and high glucose status may synergistically increase the incidence of CKD. Strict BP management may play an important role in the early prevention of CKD in individuals with worse glucose status within the young and middle-aged population. This large-scale longitudinal cohort study showed high BP and diabetes synergistically increased the risk of CKD in individuals without AHT. Strict BP management may play an important role in the early prevention of CKD in individuals with worse glucose status within the young and middle-aged population.
Associations between housing and psychological damage by earthquake and modifiable risk factors for dementia in general older adults: Tohoku Medical Megabank community-based cohort study.

Ippei Chiba, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Sayuri Tokioka, Tomohiro Nakamura, Satoshi Nagaie, Nobuo Fuse, Taku Obara, Yuka Kotozaki, Kozo Tanno, Shinichi Kuriyama, Atsushi Hozawa

Geriatrics & gerontology international　24　(6)　509-516　2024年6月

DOI： 10.1111/ggi.14867 　

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AIM: To evaluate the association between housing and psychological damage caused by the Great East Japan Earthquake (GEJE) and modifiable risk factors (MRFs) of dementia for general population of older adults. METHODS: This cross-sectional study enrolled 29 039 community-dwelling older adults (mean age 69.1 ± 2.9 years, 55.5% women). We evaluated disaster-related damage (by complete or not complete housing damage) and psychological damage (by post-traumatic stress reaction [PTSR]) after the GEJE using a self-report questionnaire. MRFs encompassed the presence of depression, social isolation, physical inactivity, smoking, and diabetes. We examined the association between disaster-related damage and MRFs using ordinary least squares and modified Poisson regression models adjusted for sociodemographic and health status variables. RESULTS: Complete housing damage and PTSR were identified in 2704 (10.0%) and 855 (3.2%) individuals, respectively. The number of MRFs was significantly larger for the individuals with complete housing damage (β = 0.23; 95% confidence interval [CI]: 0.19-0.27) and PTSR (β = 0.60; 95% CI: 0.53-0.67). Prevalence ratios (PRs) for depression and physical inactivity were higher in individuals with complete housing damage. The PRs for all domains of the MRFs were significantly higher in individuals with PTSR. CONCLUSIONS: Housing and psychological damage caused by the GEJE were associated with an increased risk factor of dementia. To attenuate the risk of dementia, especially among older victims who have experienced housing and psychological damage after a disaster, multidimensional support across various aspects of MRFs is required. Geriatr Gerontol Int 2024; ••: ••-••.
Relationship between traditional risk factors for hypertension and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study. 国際誌

Masato Takase, Naoki Nakaya, Kozo Tanno, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Tomohiro Nakamura, Takumi Hirata, Taku Obara, Mami Ishikuro, Yuka Kotozaki, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Hideki Ohmomo, Nobuo Fuse, Junichi Sugawara, Atsushi Shimizu, Yoko Izumi, Shinichi Kuriyama, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　47　(6)　1533-1545　2024年6月
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1038/s41440-024-01582-1 　

ISSN：0916-9636

eISSN：1348-4214

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Abstract Risk factors for hypertension have been emphasized in the Japanese Society of Hypertension Guidelines for the Management of Hypertension. However, large-scale studies on the association of smoking, potassium excretion, and gamma-glutamyl transferase level with BP in the Japanese population are limited. We conducted a cross-sectional study to examine the association between hypertension risk factors and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study (23,446 men and 38,921 women aged ≥20 years). A model adjusted for age, body mass index, smoking status, drinking status, estimated daily salt intake, potassium excretion, (or urinary sodium-to-potassium ratio), gamma-glutamyl transferase, physical activity, education level, status of damage to homes during the Great East Japan Earthquake, and residential areas was used. The average age and systolic blood pressure were 62.5 (10.3) years for men and 59.6 (11.3) years for women, 128.9 (16.7) mmHg for men and 124.7 (17.5) mmHg for women, respectively. Body mass index estimated daily salt intake, urinary sodium-to-potassium ratio and gamma-glutamyl transferase levels were positively associated with systolic blood pressure. Compared with never-drinkers, current drinkers who consumed 23–45 g/day and ≥46.0 g/day had significantly increased systolic blood pressure. Conversely, current smokers (1-10 cigarettes/day and 11-20 cigarettes/day) were inversely associated with systolic blood pressure compared to never-smokers. Overall, systolic blood pressure was associated with gamma-glutamyl transferase and hypertension risk factors, including body mass index, alcohol consumption, estimated daily salt intake, urinary sodium-to-potassium ratio, and potassium excretion. Our findings support the notion that lifestyle modifications should be attempted to prevent hypertension.
Relationships of Fat Mass Index and Fat-Free Mass Index with Low-Density Lipoprotein Cholesterol Levels in the Tohoku Medical Megabank Community-Based Cohort Study.

Masato Takase, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Taku Obara, Mami Ishikuro, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Yoko Izumi, Shinichi Kuriyama, Atsushi Hozawa

Journal of atherosclerosis and thrombosis　31　(6)　979-1003　2024年6月1日

DOI： 10.5551/jat.64535 　

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AIMS: Although fat mass (FM) and fat-free mass (FFM) have an impact on lipid metabolism, the relationship between different body composition phenotypes and lipid profiles is still unclear. By dividing the FM and FFM by the square of the height, respectively, the f at mass index (FMI) and fat-free mass index (FFMI) can be used to determine the variations in body composition. This study aimed to investigate the relationship of combined FMI and FFMI with low-density lipoprotein cholesterol (LDL-C) levels. METHODS: This cross-sectional study comprised 5,116 men and 13,630 women without cardiovascular disease and without treatment for hypertension, and diabetes. Following sex-specific quartile classification, FMI and FFMI were combined into 16 groups. Elevated LDL-C levels were defined as LDL-C ≥ 140 mg/dL and/or dyslipidemia treatment. Multivariable logistic regression models were used to examine the relationships between combined FMI and FFMI and elevated LDL-C levels. RESULTS: Overall, elevated LDL-C levels were found in 1,538 (30.1%) men and 5,434 (39.9%) women. In all FFMI subgroups, a higher FMI was associated with elevated LDL-C levels. Conversely, FFMI was inversely associated with elevated LDL-C levels in most FMI subgroups. Furthermore, the groups with the highest FMI and lowest FFMI had higher odds ratios for elevated LDL-C levels than those with the lowest FMI and highest FFMI. CONCLUSIONS: Regardless of FFMI, FMI was positively associated with elevated LDL-C levels. Conversely, in the majority of FMI subgroups, FFMI was inversely associated with elevated LDL-C levels.
Relationship between parity and the prevalence of chronic kidney disease in Japan considering hypertensive disorders of pregnancy and body mass index. 国際誌

Hongxin Wang, Noriyuki Iwama, Keiichi Yuwaki, You Nakamichi, Hirotaka Hamada, Hasumi Tomita, Kazuma Tagami, Rie Kudo, Natsumi Kumagai, Hirohito Metoki, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Yaegashi, Masatoshi Saito

BMC nephrology　25　(1)　166-166　2024年5月17日

DOI： 10.1186/s12882-024-03604-z 　

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BACKGROUND: Global studies exploring the relationship between parity and chronic kidney disease (CKD) are scarce. Furthermore, no study has examined the relationship between parity and CKD in Japan. Therefore, this study aimed to examine the relationship between parity and the prevalence of CKD in a Japanese population, considering the clinical history of hypertensive disorders of pregnancy (HDP) and current body mass index (BMI) based on menopausal status. METHODS: This cross-sectional study included 26,945 Japanese multiparous women (5,006 premenopausal and 21,939 postmenopausal women) and 3,247 nulliparous women (1,599 premenopausal and 1,648 postmenopausal women). Participants were divided into two groups based on their menopausal status (premenopausal and postmenopausal women). The relationship between parity and the prevalence of CKD was evaluated using a multiple logistic regression model adjusted for several covariates, including a clinical history of HDP and current BMI. RESULTS: The relationship between parity and the prevalence of CKD was not statistically significant in either premenopausal or postmenopausal multiparous women. A clinical history of HDP was significantly associated with an increased risk of CKD in premenopausal and postmenopausal multiparous women. However, the relationship between a clinical history of HDP and CKD in premenopausal women was weakened after adjusting for current BMI. Furthermore, the current BMI was significantly associated with an increased risk of CKD in both premenopausal and postmenopausal women. CONCLUSIONS: Parity is not significantly associated with the prevalence of CKD in premenopausal and postmenopausal multiparous women. A clinical history of HDP is a risk factor for CKD in both premenopausal and postmenopausal women. Current BMI is also associated with an increased risk of CKD in premenopausal and postmenopausal women. Therefore, continuous surveillance and preventive measures against CKD should be provided to women with a clinical history of HDP. In addition, maintaining an appropriate body weight is beneficial in reducing the risk of CKD.
Factors Associated With the Prevalence of Irritable Bowel Syndrome: The Miyagi Part of the Tohoku Medical Megabank Project Community-based Cohort Study. 国際誌査読有り

Kumi Nakaya, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Satoshi Nagaie, Tomohiro Nakamura, Motoyori Kanazawa, Soichi Ogishima, Nobuo Fuse, Shin Fukudo, Atsushi Hozawa

Journal of neurogastroenterology and motility　30　(2)　208-219　2024年4月30日

DOI： 10.5056/jnm23090 　

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BACKGROUND/AIMS: The objective of this research is to examine factors related to irritable bowel syndrome (IBS) prevalence in a large population-based study. METHODS: A cross-sectional study was conducted with participants in the Miyagi part of the Tohoku Medical Megabank Project Community-Based cohort study who completed the Rome II Modular Questionnaire. Multivariate odds ratios (ORs) for the presence of IBS and 95% confidence intervals (95% CIs) for the reference group were calculated for each factor. Additionally, a stratified analysis was performed by sex and age group (20-49 years, 50-64 years, and ≥ 65 years). RESULTS: Among 16 252 participants, 3025 (18.6%) had IBS, comprising 750 men (15.5%) and 2275 women (19.9%). Multivariate ORs for the presence of IBS decreased significantly with each year of age (OR, 0.98; 95% CI, 0.98-0.99). Moreover, compared with the reference group, ORs for the presence of IBS were significantly higher in individuals whose home was partially damaged by the Great East Japan Earthquake, those with < 16 years of education, those who spent less time walking, those with high perceived stress (1.77, 1.57-2.01), those with high psychological distress (1.58, 1.36-1.82), and those with high symptoms of depression (1.76, 1.60-1.94). In stratified analyses, a significant relationship was found between psychological factors and IBS prevalence in all sex and age groups. CONCLUSIONS: This large cross-sectional population-based cohort study identified several factors associated with IBS prevalence. Psychological factors were significantly associated with IBS prevalence across all age groups and sexes.
平日と休日の睡眠時間の差と家庭高血圧との関連

野路慶明, 畑中里衣子, 中谷直樹, 小暮真奈, 中谷久美, 千葉一平, 時岡紗由理, 中村智洋, 栗山進一, 寳澤篤

日本循環器病予防学会誌　59　(2)　127-127　2024年4月
出版者・発行元： (一社)日本循環器病予防学会
ISSN：1346-6267

eISSN：2759-5323
Association of physiological factors with grip and leg extension strength: tohoku medical megabank community-based cohort study. 国際誌

Yoshiaki Noji, Rieko Hatanaka, Naoki Nakaya, Mana Kogure, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Tomohiro Nakamura, Naho Tsuchiya, Haruki Momma, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Ryoichi Nagatomi, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

BMC public health　24　(1)　714-714　2024年3月5日

DOI： 10.1186/s12889-024-18244-z 　

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BACKGROUND: Upper and lower extremity muscle strength can be used to predict health outcomes. However, the difference between the relation of upper extremity muscle and of lower extremity muscle with physiological factors is unclear. This study aimed to evaluate the association between physiological data and muscle strength, measured using grip and leg extension strength, among Japanese adults. METHODS: We conducted a cross-sectional study of 2,861 men and 6,717 women aged ≥ 20 years living in Miyagi Prefecture, Japan. Grip strength was measured using a dynamometer. Leg extension strength was measured using a hydraulic isokinetic leg press machine. Anthropometry and physiological data, including blood pressure, calcaneal ultrasound bone status, pulmonary function, carotid echography, and blood information, were assessed. We used a general linear model adjusted for age, body composition, and smoking status to evaluate the association between muscle strength and physiological factors. RESULTS: Grip and leg extension strength were positively associated with bone area ratio, vital capacity, forced vital capacity, forced expiratory volume in one second, and estimated glomerular filtration rate, and negatively associated with waist circumference and percentage body fat mass in both the sexes. Diastolic blood pressure was positively associated with grip strength in both the sexes and leg extension strength in men, but not women. High-density lipoprotein cholesterol and red blood cell counts were positively associated with grip and leg extension strength in women, but not men. In both the sexes, pulse rate, total cholesterol, and uric acid were consistently associated with only leg extension strength, but not grip strength. In women, glycated hemoglobin demonstrated negative and positive associations with grip and leg extension strength, respectively. CONCLUSIONS: Grip and leg extension strength demonstrated similar associations with anthropometry, pulmonary function, and estimated glomerular filtration rate, but the associations with the other factors were not always consistent.
Dietary habits and plasma lipid concentrations in a general Japanese population. 国際誌

Mitsuharu Sato, Eiji Hishinuma, Naomi Matsukawa, Yoshiko Shima, Daisuke Saigusa, Ikuko N Motoike, Mana Kogure, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Masayuki Yamamoto, Seizo Koshiba, Kengo Kinoshita

Metabolomics : Official journal of the Metabolomic Society　20　(2)　34-34　2024年3月5日

DOI： 10.1007/s11306-024-02087-1 　

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INTRODUCTION: Accumulating data on the associations between food consumption and lipid composition in the body is essential for understanding the effects of dietary habits on health. OBJECTIVES: As part of omics research in the Tohoku Medical Megabank Community-Based Cohort Study, this study sought to reveal the dietary impact on plasma lipid concentration in a Japanese population. METHODS: We conducted a correlation analysis of food consumption and plasma lipid concentrations measured using mass spectrometry, for 4032 participants in Miyagi Prefecture, Japan. RESULTS: Our analysis revealed 83 marked correlations between six food categories and the concentrations of plasma lipids in nine subclasses. Previously reported associations, including those between seafood consumption and omega-3 fatty acids, were validated, while those between dairy product consumption and odd-carbon-number fatty acids (odd-FAs) were validated for the first time in an Asian population. Further analysis suggested that dairy product consumption is associated with odd-FAs via sphingomyelin (SM), which suggests that SM is a carrier of odd-FAs. These results are important for understanding odd-FA metabolism with regards to dairy product consumption. CONCLUSION: This study provides insight into the dietary impact on plasma lipid concentration in a Japanese population.
Combined Fat Mass and Fat-free Mass Indices and Lung Function Among Japanese Population: The Tohoku Medical Megabank Community-based Cohort Study.

Masato Takase, Mitsuhiro Yamada, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

Journal of epidemiology　34　(3)　119-128　2024年3月5日

DOI： 10.2188/jea.JE20220355 　

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BACKGROUND: Although fat mass index (FMI) and fat-free mass index (FFMI) affect lung function, FMI and FFMI are not independent of each other since FMI and FFMI were calculated as fat mass and fat-free mass divided by height squared, respectively. We aimed to examine the association of combined FMI and FFMI with lung function. METHODS: In this cross-sectional study, lung function was evaluated using forced expiratory volume at 1 s and forced vital capacity was measured using spirometry. Both FMI and FFMI were classified into sex-specific quartiles (16 groups). Analysis of covariance was used to assess the associations of combined FMI and FFMI with lung function. The trend test was conducted by stratifying the FMI and FFMI, scoring the categories from 1-4 (lowest-highest), and entering the number as a continuous term in the regression model. RESULTS: This study included 3,736 men and 8,821 women aged ≥20 years living in Miyagi Prefecture, Japan. The mean FEV1 (standard deviation) was 3.0 (0.7) L for men and 2.3 (0.5) L for women. The mean FVC was 3.8 (0.7) L for men and 2.8 (0.5) L for women. The FMI was inversely associated with lung function among all FFMI subgroups in both sexes. Conversely, FFMI was positively associated with lung function in all FMI subgroups in both sexes. CONCLUSIONS: Higher FMI was associated with lower lung function independent of FFMI; higher FFMI was associated with higher lung function independent of FMI. Reducing FMI and maintaining FFMI might be important for respiratory health.
追跡調査によって得られた日本人における眼軸伸長の危険因子の検討

西村尭幸, 國方彦志, 高田菜生子, 石川誠, 千葉一平, 中谷直樹, 寶澤篤, 布施昇男, 中澤徹

日本眼科学会雑誌　128　(臨増)　233-233　2024年3月
出版者・発行元： (公財)日本眼科学会
ISSN：0029-0203
Low Hemoglobin Level and Elevated Inflammatory Hematological Ratios Associated With Depression and Sleep Disturbance. 国際誌

Tetsuya Akaishi, Kumi Nakaya, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Sayuri Tokioka, Satoshi Nagaie, Soichi Ogishima, Atsushi Hozawa

Cureus　16　(3)　e56621　2024年3月

DOI： 10.7759/cureus.56621 　

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BACKGROUND: The relationship between blood cell profiles, including hemoglobin (Hb) levels and inflammatory hematological ratios, and mental health problems currently remains unclear. AIM: This study aimed to investigate the relationship between blood cell profiles and mental health issues, including depressive state and sleep disturbance, while adjusting for potential demographic confounders. METHODOLOGY: This retrospective, cross-sectional, observational study used a population-based medical database from the Tohoku Medical Megabank Project with more than 60,000 volunteers. Data on age, sex, daily tobacco use, body mass index, and self-reported scores on the Kessler Psychological Distress Scale (K6), Athens Insomnia Scale (AIS), and the Center for Epidemiologic Studies Depression Scale (CES-D) were collected. RESULTS: A total of 62,796 volunteers (23,663 males and 39,133 females), aged ≥20 years at the time of the blood test, agreed to participate in this study. Among the evaluated blood cell profiles, Hb, hematocrit, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were significantly correlated with the K6, AIS, and CES-D scores, with strong statistical significance (p<0.0001 for all) in bivariate correlation analyses. A significant adjusted odds ratio (aOR) of the Hb level for elevated CES-D scores (aOR=0.965 [95% CI: 0.949-0.981], p<0.0001) was confirmed after adjusting for demographic data and daily tobacco use using a logistic regression model. Sensitivity analyses revealed that these associations existed in both males and females but were more prominent in the former. In male participants, a low Hb level was significantly associated with an elevated AIS score. The evaluated inflammatory hematological ratios, including NLR, PLR, and monocyte-to-lymphocyte ratio (MLR), also showed significant aORs with the K6, AIS, and CES-D scores after adjusting for demographic background. CONCLUSION: Low Hb levels and elevated inflammatory hematological ratios (NLR, MLR, and PLR) were associated with depressive state and sleep disturbances in the general population.
The association between depressive symptoms and masked hypertension in participants with normotension measured at research center. 国際誌

Sayuri Tokioka, Naoki Nakaya, Kumi Nakaya, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Hirohito Metoki, Takahisa Murakami, Michihiro Satoh, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　47　(3)　586-597　2024年3月

DOI： 10.1038/s41440-023-01484-8 　

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Masked hypertension is a risk factor for cardiovascular diseases. However, masked hypertension is sometimes overlooked owing to the requirement for home blood pressure measurements for diagnosing. Mental status influences blood pressure. To reduce undiagnosed masked hypertension, this study assessed the association between depressive symptoms and masked hypertension. This cross-sectional study used data from the Tohoku Medical Megabank Project Community-Based Cohort Study (conducted in Miyagi Prefecture, Japan, from 2013) and included participants with normotension measured at the research center (systolic blood pressure<140 mmHg and diastolic blood pressure <90 mmHg). Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (Japanese version). Masked hypertension was defined as normotension measured at the research center and home hypertension (home systolic blood pressure ≥135 mmHg or home diastolic blood pressure ≥85 mmHg). The study comprised 6705 participants (mean age: 55.7 ± 13.7 years). Of these participants, 1106 (22.1%) without depressive symptoms and 393 (23.2%) with depressive symptoms were categorized to have masked hypertension. Sex-specific and age-adjusted least mean squares for home blood pressure, not for research blood pressure were significantly higher in the group with depressive symptoms in both sex categories. The multivariate odds ratio for masked hypertension in the patients with depressive symptoms was 1.72 (95% confidence interval: 1.26-2.34) in male participants and 1.30 (95% confidence interval: 1.06-1.59) in female ones. Depressive symptoms were associated with masked hypertension in individuals with normotension measured at the research center. Depressive symptoms may be one of the risk factors for masked hypertension. Depressive symptoms were associated with masked hypertension in individuals with normotension measured at research center.
Association of parity with the prevalence of hypertension in Japan: The Tohoku Medical Megabank Community-based cohort study. 国際誌

Hongxin Wang, Noriyuki Iwama, Keiichi Yuwaki, You Nakamichi, Hirotaka Hamada, Hasumi Tomita, Kazuma Tagami, Rie Kudo, Natsumi Kumagai, Hirohito Metoki, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Yaegashi, Masatoshi Saito

Journal of clinical hypertension (Greenwich, Conn.)　26　(2)　102-121　2024年2月

DOI： 10.1111/jch.14756 　

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This study investigated the association of parity with hypertension prevalence in Japanese women while considering a clinical history of hypertensive disorders of pregnancy (HDP) and menopausal status. This cross-sectional study included 30,530 Japanese women (6700 premenopausal; 23 830 postmenopausal). The association between parity and the prevalence of hypertension was evaluated using a multiple logistic regression model with possible confounders. In premenopausal women, no statistically significant association between parity and hypertension prevalence was found. When not adjusted for current body mass index (BMI), a linear graded association was observed between parity and the prevalence of hypertension in postmenopausal women. However, the association between parity and hypertension prevalence in postmenopausal women was attenuated after adjustment for current BMI. Both current BMI and a clinical history of HDP were significantly associated with a high risk of hypertension in both premenopausal and postmenopausal women. Our results also suggest that continuous surveillance and preventive measures for hypertension should be provided for women with HDP and high parity.
A feasibility study of provider-level implementation strategies to improve access to colorectal cancer screening for patients with schizophrenia: ACCESS2 (N-EQUITY 2104) trial. 国際誌

Masaki Fujiwara, Yuto Yamada, Tsuyoshi Etoh, Taichi Shimazu, Masafumi Kodama, Norihito Yamada, Takahiro Asada, Shigeo Horii, Takafumi Kobayashi, Teruo Hayashi, Yoshitaka Ehara, Kenji Fukuda, Keita Harada, Maiko Fujimori, Miyuki Odawara, Hirokazu Takahashi, Shiro Hinotsu, Naoki Nakaya, Yosuke Uchitomi, Masatoshi Inagaki

Implementation science communications　5　(1)　2-2　2024年1月4日

DOI： 10.1186/s43058-023-00541-0 　

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BACKGROUND: People with schizophrenia have a lower colorectal screening rate than the general population. A previous study reported an intervention using case management to encourage colorectal cancer screening for patients with schizophrenia in psychiatric outpatient settings. In this feasibility study, we developed provider-level implementation strategies and evaluated the feasibility of conducting a definitive trial in terms of the penetration of the intervention assessed at the patient level. Additionally, we examined the fidelity of strategies to implement the intervention at the provider level in a routine clinical psychiatric setting. METHODS: This was a multicenter, single-arm feasibility study with medical staff at psychiatric hospitals in Japan. The provider-level implementation strategies developed in this study included three key elements (organizing an implementation team appointed by the facility director, interactive assistance using a clear guide that outlines who in the hospital should do what, and developing accessible educational materials) to overcome major barriers to implementation of the intervention and four additional elements (progress monitoring, joint meetings and information sharing among participating sites, adaptation of encouragement methods to specific contexts, and education of on-site staff), with reference to the elements identified in the Expert Recommendations for Implementing Change (ERIC). The feasibility of the strategies was evaluated by the proportion of patients who were eligible for encouragement (patients with schizophrenia aged 40, 50, or 60) who received encouragement. We set the goal of providing encouragement to at least 40% of eligible patients at each site. RESULTS: Two public and four private psychiatric hospitals in Okayama and Shimane prefectures participated in this study. Regarding fidelity, all elements of the strategies were conducted as planned. Following the procedures in the guide, each team prepared and provided encouragement according to their own facility and region. Penetration, defined as the proportion of eligible patients who received encouragement, ranged from 33.3 to 100%; five of the six facilities achieved the target proportion. CONCLUSIONS: The provider-level implementation strategies to implement encouragement were feasible in terms of penetration of the intervention assessed at the patient level. The results support the feasibility of proceeding with a future definitive trial of these strategies. TRIAL REGISTRATION: jRCT, jRCT1060220026 . Registered on 06/04/2022.
COVID-19流行中におけるリハビリテーション専門職の抑うつと睡眠およびストレス発散に費やす時間との関係

滝澤宏和, 田山淳, 中谷直樹, 濱口豊太

行動医学研究　29　(2)　077-085　2024年
出版者・発行元： (一社)日本行動医学会
ISSN：1341-6790

eISSN：2188-0085
Effect modification by geographic area on the association between health literacy and self-rated health: a nationwide cross-sectional study in Japan

Hirono Ishikawa, Runa Ogawa, Aki Otsuki, Junko Saito, Akiko Yaguchi-Saito, Aya Kuchiba, Maiko Fujimori, Yoshiharu Fukuda, Taichi Shimazu, Masayo Hayakawa, Satoyo Hosono, Manami Inoue, Yuki Kaji, Kota Katanoda, Tomohiro Matsuda, Yutaka J. Matsuoka, Miyuki Odawara, Hirokazu Takahashi, Miyako Takahashi, Yosuke Uchitomi, Jun Umezawa, Otome Watanabe, Itsuro Yoshimi, Gary L. Kreps, Naomi Sakurai, Takumi Momosaka, Miki Akiyama, Rina Miyawaki, Ryo Okubo, Rie Akamatsu, Yui Kawasaki, Kahori Fujisaki, Luna Ogawa, Haruhiko Imamura, Kumi Nakaya, Naoki Nakaya, Seigo Mitsutake, Hiroyuki Sasai

BMC Public Health　23　(1)　2023年12月

DOI： 10.1186/s12889-023-15897-0 　

eISSN：1471-2458
The risk of withdrawal from hypertension treatment in coastal areas after the Great East Japan Earthquake: the TMM CommCohort Study. 国際誌

Rieko Hatanaka, Naoki Nakaya, Mana Kogure, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Hideaki Hashimoto, Tomohiro Nakamura, Kotaro Nochioka, Taku Obara, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　46　(12)　2718-2728　2023年12月
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1038/s41440-023-01454-0 　

ISSN：0916-9636

eISSN：1348-4214

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Abstract This study aimed to examine whether risk of withdrawal from HTTx was higher in coastal areas that were severely damaged by tsunami than in inland areas. We conducted a cross-sectional study of 9218 participants aged ≥20 years in Miyagi, Japan. The odds ratios (ORs) and confidence interval (CI) for withdrawal from HTTx in coastal and inland groups were compared using multivariate logistic regression analysis, adjusting for potential confounders. In total, 194 of 5860 and 146 of 3358 participants in the inland and coastal groups, respectively, withdrew from HTTx treatment. OR (95%CI) of withdrawal from HTTx in the coastal group was 1.46 (1.14–1.86) compared to the inland group. According to housing damage, ORs (95% CI) in the no damage, partially destroyed, and more than half destroyed coastal groups compared with the no damage inland group were 1.62 (1.04–2.50), 1.69 (1.17–2.45), and 1.08 (0.71–1.65), respectively. In conclusion, the risk of HTTx withdrawal for participants whose homes in coastal areas were relatively less damaged was significantly higher compared with those in inland areas, while the risk of HTTx withdrawal for participants whose homes were more than half destroyed was not. Post-disaster administrative support for disaster victims is considered vital for continuation of their treatment.
Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based Cohort Study.

Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Akira Narita, Taku Obara, Mami Ishikuro, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

Journal of atherosclerosis and thrombosis　30　(12)　1950-1965　2023年12月1日

DOI： 10.5551/jat.64425 　

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AIM: The influence of family history of diabetes, probably reflecting genetic and lifestyle factors, on the association of combined genetic and lifestyle risks with diabetes is unknown. We examined these associations. METHODS: This cross-sectional study included 9,681 participants in the Tohoku Medical Megabank Community-based Cohort Study. A lifestyle score, which was categorized into ideal, intermediate, and poor lifestyles, was given. Family history was obtained through a self-reported questionnaire. A polygenic risk score (PRS) was constructed in the target data (n=1,936) using publicly available genome-wide association study summary statistics from BioBank Japan. For test data (n=7,745), we evaluated PRS performance and examined the associations of combined family history and genetic and lifestyle risks with diabetes. Diabetes was defined as non-fasting blood glucose ≥ 200 mmHg, HbA1c ≥ 6.5%, and/or self-reported diabetes treatment. RESULTS: In test data, 467 (6.0%) participants had diabetes. Compared with a low genetic risk and an ideal lifestyle without a family history, the odds ratio (OR) was 3.73 (95% confidence interval [CI], 1.92-7.00) for a lower genetic risk and a poor lifestyle without a family history. Family history was significantly associated with diabetes (OR, 3.58 [95% CI, 1.73-6.98]), even in those with a low genetic risk and an ideal lifestyle. Even among participants who had an ideal lifestyle without a family history, a high genetic risk was associated with diabetes (OR, 2.49 [95% CI, 1.65-3.85]). Adding PRS to family history and conventional lifestyle risk factors improved the prediction ability for diabetes. CONCLUSIONS: Our findings support the notion that a healthy lifestyle is important to prevent diabetes regardless of genetic risk.
Association of Central Blood Pressure and Carotid Intima Media Thickness with New-Onset Hypertension in People with High Normal Blood Pressure.

Sayuri Tokioka, Naoki Nakaya, Kumi Nakaya, Masato Takase, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Hirohito Metoki, Takahisa Murakami, Michihiro Satoh, Tomohiro Nakamura, Taku Obara, Yohei Hamanaka, Tomoko Kobayashi, Akira Uruno, Junichi Sugawara, Eiichi N Kodama, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

Journal of atherosclerosis and thrombosis　30　(12)　1905-1916　2023年12月1日

DOI： 10.5551/jat.64151 　

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AIM: People with high normal blood pressure (BP) have a higher risk of cardiovascular events than those with normal BP; therefore, progression to hypertension (HT) should be prevented. We aimed to assess the HT risk using central BP and carotid intima media thickness (CIMT) in people with high normal BP. METHODS: This prospective cohort study used the Tohoku Medical Megabank Community-Based Project Cohort Study (conducted from 2013 in Miyagi Prefecture in Japan). The participants had a high normal BP, defined as a systolic BP of 120-139 mmHg and diastolic BP ＜90 mmHg using brachial BP measurement during the baseline survey. The outcome was new-onset HT during the secondary survey, conducted four years after the baseline survey. RESULTS: Overall, 4,021 participants with high normal BP during the baseline survey, with an average age of 58.7 years, were included; 1,030 (26%) were diagnosed with new-onset HT during the secondary survey, 3.5± 0.7 years after the baseline survey. The multivariable odds ratio (95% confidence interval) for HT in the highest versus lowest quartile of central BP was 1.7 (1.2-2.4, p=0.0030), and that of CIMT was 1.8 (1.4-2.4, p＜0.001). Subgroup analysis according to age (＜60 and ≥ 60 years) and sex revealed that the central BP was influential in groups with younger age and female individuals; CIMT was influential in all groups. CONCLUSIONS: Higher central BP and thicker CIMT at the baseline were correlated with new-onset HT in individuals with high normal BP, independent of brachial systolic BP and other cardiovascular risk factors.
Effects of greenery at different heights in neighbourhood streetscapes on leisure walking: a cross-sectional study using machine learning of streetscape images in Sendai City, Japan. 国際誌査読有り

Shusuke Sakamoto, Mana Kogure, Tomoya Hanibuchi, Naoki Nakaya, Atsushi Hozawa, Tomoki Nakaya

International journal of health geographics　22　(1)　29-29　2023年11月8日

DOI： 10.1186/s12942-023-00351-6 　

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BACKGROUND: It has been pointed out that eye-level greenery streetscape promotes leisure walking which is known to be a health -positive physical activity. Most previous studies have focused on the total amount of greenery in the eye-level streetscape to investigate its association with walking behaviour. While it is acknowledged that taller trees contribute to greener environments, providing enhanced physical and psychological comfort compared to lawns and shrubs, the examination of streetscape metrics specifically focused on greenery height remains largely unexplored. Therefore, this study examined the relationship between objective indicators of street greenery categorized by height from a pedestrian viewpoint and leisure walking time. METHODS: We created streetscape indices of street greenery using Google Street View Images at 50-m intervals in an urban area in Sendai City, Japan. The indices were classified into four ranges according to the latitude of the virtual hemisphere centred on the viewer. We then investigated their relationship to self-reported leisure walking. RESULTS: Positive associations were identified between the street greenery in higher positions and leisure walking time, while there was no significant association between the greenery in lower positions. CONCLUSION: The findings indicated that streets with rich greenery in high positions may promote residents' leisure walking, indicating that greenery in higher positions contributes to thermally comfortable and aesthetic streetscapes, thus promoting leisure walking. Increasing the amount of greenery in higher positions may encourage residents to increase the time spent leisure walking.
Blue light imaging and linked color imaging as a screening mode for esophageal squamous cell carcinoma in high-risk patients: Multicenter randomized trial. 国際誌

Yohei Ogata, Waku Hatta, Tomoyuki Koike, So Takahashi, Tamotsu Matsuhashi, Tomoyuki Oikawa, Wataru Iwai, Sho Asonuma, Hideki Okata, Motoki Ohyauchi, Hirotaka Ito, Yasuhiko Abe, Yu Sasaki, Masashi Kawamura, Masahiro Saito, Kaname Uno, Fumiyoshi Fujishima, Tomohiro Nakamura, Naoki Nakaya, Katsunori Iijima, Atsushi Masamune

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society　35　(7)　835-844　2023年11月

DOI： 10.1111/den.14538 　

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OBJECTIVES: Blue light imaging (BLI) and linked color imaging (LCI) are superior to conventional white light imaging for detecting esophageal squamous cell carcinoma (ESCC). Hence, we compared their diagnostic performances in ESCC screening. METHODS: This open-labeled, randomized controlled trial was performed at seven hospitals. Patients with a high risk of ESCC were randomly assigned to the BLI group (BLI followed by LCI) and LCI group (LCI followed by BLI). The primary endpoint was the detection rate of ESCC in the primary mode. The main secondary endpoint was its miss rate in the primary mode. RESULTS: In total, 699 patients were enrolled. The detection rate of ESCC did not significantly differ between the BLI and LCI groups [4.0% (14/351) vs. 4.9% (17/348); p = 0.565]; however, the number of patients with ESCC tended to be smaller in the BLI group (19 vs. 30). Notably, the miss rate of ESCC was lower in the BLI group [26.3% (5/19) vs. 63.3% (19/30); p = 0.012] and LCI detected no ESCCs missed by BLI. The sensitivity was higher in BLI (75.0% vs. 47.6%; p = 0.042); on the other hand, the positive predictive value in BLI tended to be lower (28.8% vs. 45.5%; p = 0.092). CONCLUSIONS: The detection rates of ESCC did not significantly differ between BLI and LCI. Although BLI may have a potential to be advantageous over LCI for the diagnosis of ESCC, it is still unclear whether BLI is superior to LCI, and a further large-scale study is needed.
東北メディカル・メガバンク計画地域住民コホート調査詳細三次調査(岩手)の進捗

事崎由佳, 武部典子, 山崎弥生, 赤井純子, 照井春樹, 岩渕光子, 大塚耕太郎, 中谷直樹, 寳澤篤, 丹野高三

日本公衆衛生学会総会抄録集　82回　369-369　2023年10月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
東北メディカル・メガバンク計画地域住民コホート調査詳細三次調査(岩手)の進捗

事崎由佳, 武部典子, 山崎弥生, 赤井純子, 照井春樹, 岩渕光子, 大塚耕太郎, 中谷直樹, 寳澤篤, 丹野高三

日本公衆衛生学会総会抄録集　82回　369-369　2023年10月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
東北メディカル・メガバンク計画地域住民コホート調査詳細三次調査(岩手)の進捗

事崎由佳, 武部典子, 山崎弥生, 赤井純子, 照井春樹, 岩渕光子, 大塚耕太郎, 中谷直樹, 寳澤篤, 丹野高三

日本公衆衛生学会総会抄録集　82回　(Suppl.1)　369-369　2023年10月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060

eISSN：1349-9092
Carotid Intima Media Thickness and Risk Factor for Atherosclerosis: Tohoku Medical Megabank Community-Based Cohort Study.

Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

Journal of atherosclerosis and thrombosis　30　(10)　1471-1482　2023年10月1日

DOI： 10.5551/jat.64039 　

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AIM: We examined the association between the carotid intima medica thickness (cIMT) and risk factors for atherosclerosis based on the Japan Atherosclerosis Society 2022 Atherosclerosis Prevention Guideline. METHODS: Using data from the Tohoku Medical Megabank Community-based Cohort Study, we performed a cross-sectional study that enrolled 13,366 participants (age ≥ 20 years) with an analysis of covariance to assess associations between cIMT and risk factors for atherosclerosis. The maximum common carotid artery was measured using high-resolution B-mode ultrasound. Analysis was conducted in the model adjusted for age, sex, smoking status, drinking status, body mass index (BMI), systolic blood pressure (SBP), glycated hemoglobin (HbA1c), high-density lipoprotein-cholesterol (HDL-C), non-high-density lipoprotein-cholesterol (non-HDL-C), and height. RESULTS: In this study cohort, the average age and cIMT were 57.3 (13.8) years and 0.61 (0.13) mm, respectively, which included 3,988 males (29.8%). Males had a higher cIMT than did the females. Age, height, BMI, SBP, HbA1c, and non-HDL-C were positively associated with cIMT. HDL-C was inversely associated with cIMT. Compared with never drinkers, current drinkers (≥ 46.0 g/day) had a significantly decreased cIMT. CONCLUSIONS: The cIMT was associated with atherosclerosis risk factors including age, sex, BMI, SBP, HbA1c, non-HDL-C, and HDL-C, and adequate control of risks in high-risk individuals might be required to prevent atherosclerotic cardiovascular diseases.
Association Between Olfactory Test Data with Multiple Levels of Odor Intensity and Suspected Cognitive Impairment: A Cross-Sectional Study. 国際誌

Shuichi Sato, Takao Imaeda, Shunji Mugikura, Naoko Mori, Masaki Takanashi, Kazumi Hayakawa, Tomo Saito, Makiko Taira, Akira Narita, Mana Kogure, Ippei Chiba, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Ryosuke Ishiwata, Tomohiro Nakamura, Ikuko N Motoike, Naoki Nakaya, Seizo Koshiba, Kengo Kinoshita, Shinichi Kuriyama, Soichi Ogishima, Fuji Nagami, Nobuo Fuse, Atsushi Hozawa

Journal of Alzheimer's disease : JAD　95　(4)　1469-1480　2023年9月11日

DOI： 10.3233/JAD-230318 　

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BACKGROUND: Olfactory function decline has recently been reported to be associated with a risk of cognitive impairment. Few population-based studies have included younger adults when examining the association between olfactory test data with multiple odor intensities and suspected cognitive impairment. OBJECTIVE: We investigated the association between high-resolution olfactory test data with fewer odors and suspected cognitive impairments. We also examined the differences between older and younger adults in this association. METHODS: The Japanese version of the Montreal Cognitive Assessment (MoCA-J) was administered to 1,450 participants, with three odor-intensity-level olfactometry using six different odors. Logistic regressions to discriminate suspected cognitive impairment were conducted to examine the association, adjusted for age, sex, education duration, and smoking history. Data were collected from the Program by Tohoku University Tohoku Medical Megabank Organization, with an additional olfactory test conducted between 2019 and 2021. RESULTS: We generally observed that the lower the limit of distinguishable odor intensity was, the higher the MoCA-J score was. The combination of spearmint and stuffy socks contributed most to the distinction between suspected and unsuspected cognitive impairment. Furthermore, the association was significant in women aged 60-74 years (adjusted odds ratio 0.881, 95% confidence interval [0.790, 0.983], p = 0.024). CONCLUSIONS: The results indicate an association between the limit of distinguishable odor intensity and cognitive function. The olfactory test with multiple odor intensity levels using fewer odors may be applicable for the early detection of mild cognitive impairment, especially in older women aged 60-74 years.
分娩回数と高血圧との関連東北メディカル・メガバンク機構地域住民コホート調査

内堀洪欣, 岩間憲之, 湯脇恵一, 中道洋, 濱田裕貴, 富田芙弥, 田上和磨, 工藤理永, 熊谷奈津美, 目時弘仁, 中谷直樹, 寳澤篤, 栗山進一, 八重樫伸生, 齋藤昌利

日本妊娠高血圧学会雑誌　29　G-06　2023年9月
出版者・発行元： (一社)日本妊娠高血圧学会
ISSN：1880-3172
高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連東北メディカル・メガバンク地域住民コホート調査

高瀬雅仁, 平田匠, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 目時弘仁, 佐藤倫広, 小原拓, 栗山進一, 田宮元, 寳澤篤

日本高血圧学会総会プログラム・抄録集　45回　261-261　2023年9月
出版者・発行元： (NPO)日本高血圧学会
高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連東北メディカル・メガバンク地域住民コホート調査

高瀬雅仁, 平田匠, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 目時弘仁, 佐藤倫広, 小原拓, 栗山進一, 田宮元, 寳澤篤

日本高血圧学会総会プログラム・抄録集　45回　358-358　2023年9月
出版者・発行元： (NPO)日本高血圧学会
Associations between birth weight and lung function in a Japanese adult population: The tohoku medical megabank community-based cohort study. 国際誌

Takashi Ohe, Mitsuhiro Yamada, Atsushi Hozawa, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Nobuo Fuse, Shinichi Kuriyama, Ayumi Mitsune, Ayumi Suzuki, Shuichiro Matsumoto, Tetsuya Hatakeyama, Chikashi Iwasaki, Manami Suzuki, Naoya Fujino, Tadahisa Numakura, Tomohiro Ichikawa, Akira Koarai, Tsutomu Tamada, Masayuki Yamamoto, Masakazu Ichinose, Hisatoshi Sugiura

Respiratory investigation　61　(5)　588-600　2023年9月

DOI： 10.1016/j.resinv.2023.06.004 　

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BACKGROUND: Birth weight, as a measure of intrauterine growth, is commonly used in epidemiological studies and is reported to be associated with adult lung function. However, findings regarding this association in previous studies have been inconsistent. Furthermore, no studies have reported associations stratified by age or smoking status, or adjusted for eosinophil count or other parameters related to type 2 airway inflammation. METHODS: This cross-sectional study included 2632 men and 7237 women aged ≥20 years living in Miyagi Prefecture, Japan. Lung function was assessed based on spirometry. Birth weight data were obtained through a questionnaire survey. Analysis of covariance was used to evaluate the associations between birth weight and lung function, adjusting for potential confounders. Stratified analyses by age and smoking status were also conducted, together with a sub-analysis for low birth-weight participants. RESULTS: Birth weight was positively associated with forced expiratory volume in 1 s (FEV1) for both sexes and with vital capacity in women, after adjusting for height, age, smoking status, and parameters related to type 2 airway inflammation. The stratified analysis for smoking status revealed associations in never-smokers and ex-smokers. When stratified by age, the associations were confirmed in middle-aged participants. The effect of smoking status on the FEV1 of low birth-weight participants was not significant. CONCLUSIONS: Our analysis of a large, Japanese adult population showed that birth weight was independently and positively associated with adult lung function, even after adjustment for age, height, smoking status, and parameters related to type 2 airway inflammation.
A Noelin-organized extracellular network of proteins required for constitutive and context-dependent anchoring of AMPA-receptors. 国際誌

Sami Boudkkazi, Jochen Schwenk, Naoki Nakaya, Aline Brechet, Astrid Kollewe, Harumi Harada, Wolfgang Bildl, Akos Kulik, Lijin Dong, Afia Sultana, Gerd Zolles, Uwe Schulte, Stanislav Tomarev, Bernd Fakler

Neuron　111　(16)　2544-2556　2023年8月16日

DOI： 10.1016/j.neuron.2023.07.013 　

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Information processing and storage in the brain rely on AMPA-receptors (AMPARs) and their context-dependent dynamics in synapses and extra-synaptic sites. We found that distribution and dynamics of AMPARs in the plasma membrane are controlled by Noelins, a three-member family of conserved secreted proteins expressed throughout the brain in a cell-type-specific manner. Noelin tetramers tightly assemble with the extracellular domains of AMPARs and interconnect them in a network-like configuration with a variety of secreted and membrane-anchored proteins including Neurexin1, Neuritin1, and Seizure 6-like. Knock out of Noelins1-3 profoundly reduced AMPARs in synapses onto excitatory and inhibitory (inter)neurons, decreased their density and clustering in dendrites, and abolished activity-dependent synaptic plasticity. Our results uncover an endogenous mechanism for extracellular anchoring of AMPARs and establish Noelin-organized networks as versatile determinants of constitutive and context-dependent neurotransmission.
Increasing disparities in cancer screening among people with severe mental illness during the COVID-19 pandemic. 国際誌

Masaki Fujiwara, Yuto Yamada, Taichi Shimazu, Naoki Nakaya, Shiro Hinotsu, Maiko Fujimori, Yosuke Uchitomi, Masatoshi Inagaki

Schizophrenia research　258　18-20　2023年8月

DOI： 10.1016/j.schres.2023.07.006 　
The Association of Lung Function and Carotid Intima-Media Thickness in a Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study.

Masato Takase, Mitsuhiro Yamada, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

Journal of atherosclerosis and thrombosis　30　(8)　1022-1044　2023年8月1日

DOI： 10.5551/jat.63826 　

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AIM: Impaired lung function is associated with atherosclerotic vascular events. Carotid intima-media thickness (cIMT) is a marker for subclinical atherosclerosis. However, few studies have examined the association between lung function and cIMT among never smokers or individuals stratified by age. We investigated the association between lung function and cIMT in the Japanese population. METHODS: We conducted a cross-sectional study of 3,716 men and 8,765 women aged 20 years or older living in Miyagi Prefecture, Japan. Lung function was evaluated using forced expiratory volume at 1 s (FEV1) and forced vital capacity (FVC) was measured using spirometry. The maximum common carotid artery was measured using high-resolution B-mode ultrasound. An analysis of covariance was used to assess associations between lung function and cIMT and adjusted for potential confounders. A linear trend test was conducted by scoring the categories from 1 (lowest) to 4 (highest) and entering the score as a continuous term in the regression model. RESULTS: After adjusting for potential confounders including passive smoking, lower FEV1 and FVC were associated with higher cIMT in both men and women (P＜0.001 for linear trend). This association was confirmed even when we restricted our study to never smokers. Furthermore, even when we stratified by age, an inverse association between lung function and cIMT was confirmed in middle-aged (40-64 years) and elderly participants (65-74 years). CONCLUSIONS: Lower lung function was associated with higher cIMT in the Japanese population independent of age and smoking. Assessment of atherosclerosis or lung function may be required for individuals with lower lung function or atherosclerosis.
Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background.

Makiko Taira, Shunji Mugikura, Naoko Mori, Atsushi Hozawa, Tomo Saito, Tomohiro Nakamura, Hideyasu Kiyomoto, Tadao Kobayashi, Soichi Ogishima, Fuji Nagami, Akira Uruno, Ritsuko Shimizu, Tomoko Kobayashi, Jun Yasuda, Shigeo Kure, Miyuki Sakurai, Ikuko N Motoike, Kazuki Kumada, Naoki Nakaya, Taku Obara, Kentaro Oba, Atsushi Sekiguchi, Benjamin Thyreau, Tatsushi Mutoh, Yuji Takano, Mitsunari Abe, Norihide Maikusa, Yasuko Tatewaki, Yasuyuki Taki, Nobuo Yaegashi, Hiroaki Tomita, Kengo Kinoshita, Shinichi Kuriyama, Nobuo Fuse, Masayuki Yamamoto

JMA journal　6　(3)　246-264　2023年7月14日

DOI： 10.31662/jmaj.2022-0220 　

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The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study (TMM Brain MRI Study) was established to collect multimodal information through neuroimaging and neuropsychological assessments to evaluate the cognitive function and mental health of residents who experienced the Great East Japan Earthquake (GEJE) and associated tsunami. The study also aimed to promote advances in personalized healthcare and medicine related to mental health and cognitive function among the general population. We recruited participants for the first (baseline) survey starting in July 2014, enrolling individuals who were participating in either the TMM Community-Based Cohort Study (TMM CommCohort Study) or the TMM Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). We collected multiple magnetic resonance imaging (MRI) sequences, including 3D T1-weighted sequences, magnetic resonance angiography (MRA), diffusion tensor imaging (DTI), pseudo-continuous arterial spin labeling (pCASL), and three-dimensional fluid-attenuated inversion recovery (FLAIR) sequences. To assess neuropsychological status, we used both questionnaire- and interview-based rating scales. The former assessments included the Tri-axial Coping Scale, Impact of Event Scale in Japanese, Profile of Mood States, and 15-item Depression, Anxiety, and Stress Scale, whereas the latter assessments included the Mini-Mental State Examination, Japanese version. A total of 12,164 individuals were recruited for the first (baseline) survey, including those unable to complete all assessments. In parallel, we returned the MRI results to the participants and subsequently shared the MRI data through the TMM Biobank. At present, the second (first follow-up) survey of the study started in October 2019 is underway. In this study, we established a large and comprehensive database that included robust neuroimaging data as well as psychological and cognitive assessment data. In combination with genomic and omics data already contained in the TMM Biobank database, these data could provide new insights into the relationships of pathological processes with neuropsychological disorders, including age-related cognitive impairment.
Perceptions toward issues in cancer care for people with mental illness among psychiatric care providers: A questionnaire study. 国際誌

Yuto Yamada, Masaki Fujiwara, Tsuyoshi Etoh, Riho Wada, Shinichiro Inoue, Yoshiko Mimaki, Masafumi Kodama, Yusaku Yoshimura, Shigeo Horii, Takanori Matsushita, Maiko Fujimori, Taichi Shimazu, Naoki Nakaya, Shiro Hinotsu, Masahiro Tabata, Kenji Tamura, Yosuke Uchitomi, Norihito Yamada, Kiwamu Nagoshi, Masatoshi Inagaki

Psycho-oncology　32　(7)　1022-1029　2023年7月

DOI： 10.1002/pon.6143 　

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OBJECTIVES: To reduce cancer care disparities in people with mental illness, this study aimed to quantify psychiatric care providers' perceptions regarding issues that are insufficiently addressed or difficult to address. METHODS: Psychiatric care providers at 23 psychiatric hospitals in Japan were surveyed using mail questionnaires. Respondents were asked to rate 15 items with four categories related to insufficiencies/difficulties in cancer care for patients with mental illness on a five-point Likert scale. We analyzed the proportion of respondents who answered "insufficient/difficult" for each item. RESULTS: A total of 255 (76.3%) psychiatric care providers responded. For questions related to the skills and attitudes of psychiatric professionals, 48.3%-58.4% of respondents perceived that efforts for supporting cancer screening and treatment were insufficient. For the questions related to collaborations between cancer and psychiatric care providers, 75.3% of respondents perceived that inpatient visits between psychiatric and cancer hospitals were insufficient. For the questions related to in-psychiatric-hospital medical systems, 50.2%-87.2% of respondents perceived that support for screening, diagnosis/treatment, and palliative care for psychiatric inpatients were insufficient/difficult. 41.9%-57.4% of respondents perceived that social services in the community were insufficient. CONCLUSIONS: This study clarified the level of insufficiency/difficulty perceived by psychiatric care providers regarding issues related to cancer care for people with mental illness. Psychiatric care providers are required to have knowledge and skills in cancer screening and treatment. To improve access to cancer prevention, treatment, and palliative care, it may be helpful to establish systems to promote coordination between cancer hospitals and psychiatric hospitals.
Effect of social participation on the association between frailty and disability. 国際誌

Toshimasa Sone, Naoki Nakaya, Yumi Sugawara, Sanae Matsuyama, Ichiro Tsuji

Archives of gerontology and geriatrics　110　104989-104989　2023年7月

DOI： 10.1016/j.archger.2023.104989 　

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OBJECTIVES: To examine whether social participation affects the association between frailty and disability. METHODS: A baseline survey conducted from December 1 to 15, 2006, included 11,992 participants who were classified based on the Kihon Checklist into three categories and based on the number of activities in which they socially participated into four categories. The study outcome, incident functional disability, was defined as in Long-Term Care Insurance certification. A Cox proportional hazards model was used to calculate hazard ratios (HRs) for incident functional disability according to frailty and social participation categories. Combination analysis was performed between the nine groups using the above-mentioned Cox proportional hazards model. RESULTS: During the 13-year follow-up (107,170 person-years), 5,732 incident cases of functional disability were certified. Compared with the robust group, the other groups had significantly higher incident functional disability. However, the HRs for those participating in social activities were lower than that for those not participating in any activity [1.52 (pre-frail + none group); 1.31 (pre-frail + one activity group); 1.42 (pre-frail + two activities group); 1.37 (pre-frail + three activities group); 2.35 (frail + none group); 1.87 (frail + one activity group); 1.85 (frail + two activities group); and 1.71 (frail + three activities group)]. CONCLUSIONS: The risk of functional disability for those participating in social activities was lower than that for those not participating in any activity, irrespective of being pre-frail or frail. Comprehensive social systems for disability prevention need to focus on social participation in frail older adults.
Characteristics of disorders of gut-brain interaction in the Japanese population in the Rome Foundation Global Epidemiological Study. 国際誌

Shin Fukudo, Kumi Nakaya, Tomohiko Muratsubaki, Naoki Nakaya, Atsushi Hozawa, Shrikant I Bangdiwala, Olafur S Palsson, Ami D Sperber, Motoyori Kanazawa

Neurogastroenterology and motility　35　(6)　e14581　2023年6月

DOI： 10.1111/nmo.14581 　

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BACKGROUND: The aims were to use Japanese data from the Rome Foundation Global Epidemiological Study (RFGES) to test the hypotheses that severity of gastrointestinal (GI) symptoms and psychosocial disturbance are ordered as Rome IV irritable bowel syndrome (IBS) > Rome III IBS > DGBI, not IBS > others. METHODS: Subjects were 2504 Japanese in the RFGES. We assessed DGBI/IBS diagnoses with Rome IV/III, IBS Symptom Severity Scale (IBS-SSS), Patient Health Questionnaire (PHQ) for anxiety/depression and non-GI somatic symptoms, PROMIS-10 for quality of life (QOL), Work Productivity and Activity Impairment (WPAI) Questionnaire, parts of Self-reported IBS Questionnaire (SIBSQ) for meal effect and stress effect, Food Frequency Questionnaire, and medication questions. KEY RESULTS: The prevalence of Rome IV DGBI was as follows; IBS-C 0.5%, IBS-D 0.8%, IBS-M 0.8%, IBS-U 0.1%, unspecified functional bowel disorder 10.7%, postprandial distress syndrome 2.2%, and epigastric pain syndrome 0.3%. Rome III IBS prevalence; IBS-C 3.0%, IBS-D 3.1%, IBS-M 2.7%, and IBS-U 0.6%. Comparison among Rome IV IBS (n = 54), Rome III IBS (n = 197), other DGBI (n = 746), others (n = 1389) revealed significant order as Rome IV IBS > Rome III IBS > other DGBI > others in IBS-SSS, anxiety/depression, activity impairment, non-GI symptoms, physical QOL, mental QOL, exacerbated symptoms by meals and perceived stress (all p < 0.001). CONCLUSIONS & INFERENCES: These findings support the study hypotheses. Data from Japan as a culturally homogenous country suggest Rome IV IBS is more severe and hence has more gut-brain psychobehavioral involvement than Rome III IBS.
Consumption of 2 Green Kiwifruits Daily Improves Constipation and Abdominal Comfort-Results of an International Multicenter Randomized Controlled Trial. 国際誌

Richard Gearry, Shin Fukudo, Giovanni Barbara, Barbara Kuhn-Sherlock, Juliet Ansell, Paul Blatchford, Sarah Eady, Alison Wallace, Christine Butts, Cesare Cremon, Maria Raffaella Barbaro, Isabella Pagano, Yohei Okawa, Tomohiko Muratubaki, Tomoko Okamoto, Mikiko Fuda, Yuka Endo, Michiko Kano, Motoyori Kanazawa, Naoki Nakaya, Kumi Nakaya, Lynley Drummond

The American journal of gastroenterology　118　(6)　1058-1068　2023年6月1日

DOI： 10.14309/ajg.0000000000002124 　

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INTRODUCTION: Consumption of green kiwifruit is known to relieve constipation. Previous studies have also reported improvements in gastrointestinal (GI) comfort. We investigated the effect of consuming green kiwifruit on GI function and comfort. METHODS: Participants included healthy controls (HC, n = 63), patients with functional constipation (FC, n = 60) and constipation-predominant irritable bowel syndrome (IBS-C, n = 61) randomly assigned to consume two green kiwifruit or psyllium (7.5 g) per day for 4 weeks, followed by a 4-week wash-out, then the other treatment for 4 weeks. The primary outcome was the number of complete spontaneous bowel movements (CSBM) per week. Secondary outcomes of GI comfort, including the gastrointestinal symptom rating scale (GSRS), a validated instrument. Data (intent-to-treat (ITT)) were analysed as difference from baseline using repeated measures analysis of variance suitable for AB/BA cross-over design. RESULTS: Consumption of green kiwifruit was associated with a clinically relevant increase of ≥ 1.5 CSBM per week (FC; 1.53, p<0.0001, IBS-C; 1.73, p=0.0003), and significantly improved measures of GI comfort (GSRS total score) in constipated participants (FC, p<0.0001; IBS-C, p<0.0001). No significant adverse events were observed. DISCUSSION: This study provides original evidence that the consumption of a fresh, whole fruit has demonstrated clinically relevant increases in CSBM and improved measures of GI comfort constipated populations. Green kiwifruit are a suitable dietary treatment for relief of constipation and associated GI comfort.
Association between Low Forced Vital Capacity and High Pneumonia Mortality, and Impact of Muscle Power. 国際誌

Nanako Shiokawa, Tatsuma Okazaki, Yoshimi Suzukamo, Midori Miyatake, Mana Kogure, Naoki Nakaya, Atsushi Hozawa, Satoru Ebihara, Shin-Ichi Izumi

Journal of clinical medicine　12　(9)　2023年5月4日

DOI： 10.3390/jcm12093272 　

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Impaired % predicted value forced vital capacity (% FVC) is related to higher all-cause mortality in aged adults, and strong muscle force may improve this relationship. A muscle disease, sarcopenia, causes higher mortality. We aimed to identify the unknown disease that relates impaired % FVC with higher mortality in aged adults among the three major leading causes of death, and the effect of strong leg force on this relationship. Cox proportional hazard model analyzed the longitudinal Tsurugaya cohort that registered 1048 aged Japanese for 11 years. The primary outcome was the relationship between % FVC and mortality by cancer, cardiovascular disease, or pneumonia. Exposure variables were % FVC or leg force divided by 80% or median values, respectively. The secondary outcome was the effects of leg force on the relationship. Among the diseases, % FVC < 80% was related only to higher pneumonia mortality (hazard ratio [HR], 4.09; 95% CI, 1.90-8.83) relative to the % FVC ≥ 80% group before adjustment. Adding the leg force as an explanatory variable reduced the HR to 3.34 (1.54-7.25). Weak leg force might indicate sarcopenia, and its prevention may improve higher pneumonia mortality risk related to impaired % FVC, which we may advise people in clinical settings.
高齢者における尿Na/K比の血圧への影響は非高齢者より大きい

平田匠, 小暮真奈, 中村智洋, 小原拓, 中谷直樹, 栗山進一, 丹野高三, 寳澤篤

日本老年医学会雑誌　60　(Suppl.)　178-178　2023年5月
出版者・発行元： (一社)日本老年医学会
ISSN：0300-9173
抑うつ症状と家庭高血圧発症リスクの関連東北メディカル・メガバンク計画地域住民コホート調査

時岡紗由理, 中谷直樹, 中谷久美, 小暮真奈, 千葉一平, 畑中里衣子, 菅野郁美, 小原拓, 栗山進一, 寳澤篤

日本循環器病予防学会誌　58　(2)　146-146　2023年5月
出版者・発行元： (一社)日本循環器病予防学会
ISSN：1346-6267
慢性腎臓病発症に対する高血圧と糖尿病の複合効果

遠山真弥, 佐藤倫広, 村上任尚, 橋本英明, 中山晋吾, 小原拓, 中谷直樹, 森建文, 大久保孝義, 今井潤, 寳澤篤, 目時弘仁

日本腎臓学会誌　65　(3)　259-259　2023年5月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
Association between the extent of house collapse and urine sodium-to-potassium ratio of victims affected by the 2011 Great East Japan Earthquake and Tsunami: a cross-sectional study. 国際誌

Takahiro Mikami, Kozo Tanno, Ryohei Sasaki, Nobuyuki Takanashi, Yuka Kotozaki, Koichi Asahi, Fumitaka Tanaka, Shinichi Omama, Mana Kogure, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Atsushi Hozawa, Jiro Hitomi, Kiyomi Sakata, Makoto Sasaki

Hypertension research : official journal of the Japanese Society of Hypertension　46　(5)　1247-1256　2023年5月
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1038/s41440-023-01190-5 　

ISSN：0916-9636

eISSN：1348-4214

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Abstract People who experience natural disasters have a high risk of developing cardiovascular diseases. We investigated the association between the extent of house collapse and urine sodium-to-potassium (UNa/K) ratio of 2011 Great East Japan Earthquake victims. We used the baseline survey data of the Tohoku Medical Megabank Project Community-Based Cohort Study of 29 542 individuals (aged 20–74 years) residing in the affected areas. The UNa/K ratio was calculated using spot urinary electrolyte values. Analysis of covariance was used to calculate the multivariate-adjusted geometric means of the UNa/K ratio in the following groups stratified according to the self-reported extent of house collapse: total collapse (TC), half collapse (HC), partial collapse (PC), and no damage (ND). Multivariable-adjusted odds ratios (ORs) for a high UNa/K ratio were calculated using logistic regression. The TC, HC, PC, and ND groups comprised 5 359 (18.1%), 3 576 (12.1%), 7 331 (24.8%), and 13 276 (44.9%) participants, respectively. The TC (3.33; 95% confidence interval [CI], 3.28–3.38), HC (3.37; 3.30–3.43), and PC (3.32; 3.28–3.37) groups had significantly higher multivariate-adjusted geometric means of the UNa/K ratio than the ND (3.24; 3.21–3.27) group. The multivariable-adjusted ORs (95% CIs) for a high UNa/K ratio in the TC, HC, and PC groups vs. the ND group were 1.07 (0.99–1.15), 1.20 (1.11–1.31), and 1.20 (1.12–1.28), respectively. Similar associations between house collapse and UNa/K ratio were observed for both sexes. We report that victims of a natural disaster tend to have a diet with high sodium-to-potassium ratio.
Smoking history and severe atrophic gastritis assessed by pepsinogen are risk factors for the prevalence of synchronous gastric cancers in patients with gastric endoscopic submucosal dissection: a multicenter prospective cohort study.

Waku Hatta, Tomoyuki Koike, Sho Asonuma, Hideki Okata, Kaname Uno, Tomoyuki Oikawa, Wataru Iwai, Makoto Yonechi, Daisuke Fukushi, Shoichi Kayaba, Ryosuke Kikuchi, Motoki Ohyauchi, Jun Fushiya, Ryuhei Maejima, Yasuhiko Abe, Masashi Kawamura, Junya Honda, Yutaka Kondo, Naohiro Dairaku, Kazuaki Norita, Kenta Watanabe, Kiichi Takahashi, Hiroharu Echigo, Yasuaki Abe, Hiroyuki Endo, Tomoki Okata, Tatsuya Hoshi, Tomohiro Nakamura, Naoki Nakaya, Katsunori Iijima, Atsushi Masamune

Journal of gastroenterology　58　(5)　433-443　2023年5月

DOI： 10.1007/s00535-023-01967-y 　

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BACKGROUND: No studies have evaluated the relationship between lifestyle and synchronous gastric cancers (SGCs) in patients with endoscopic submucosal dissection (ESD) for early gastric cancers (EGCs). Using data from the Tohoku gastrointestinal (GI) study, we aimed to identify factors associated with SGCs. METHODS: Tohoku GI study is a multicenter prospective cohort study investigating the relationship between lifestyle and metachronous gastric cancers. Patients who had a schedule to undergo ESD for primary EGCs were enrolled. We used logistic regression analysis to examine the relationship of 15 candidate factors, including lifestyle, with the prevalence of SGCs in this study. RESULTS: Of 850 patients between 2016 and 2019, 16.0% (136 patients) had SGCs. In multivariate analysis, smoking history (odds ratio [OR], 1.93; p = 0.048) and severe atrophic gastritis assessed by pepsinogen (OR, 1.92; p = 0.004) were risk factors for the prevalence of SGCs. Regarding smoking, current smoking (OR, 2.33; p = 0.021), but not former smoking (OR, 1.76; p = 0.098), was a significant risk factor for its prevalence. In the stratified analysis, severe atrophic gastritis assessed by pepsinogen was a risk factor in patients without Helicobacter pylori (H. pylori) eradication (OR, 2.10; p = 0.002), but not a risk factor in those with H. pylori eradication (OR, 0.75; p = 0.737). CONCLUSION: Smoking history was a risk factor for the prevalence of SGCs in patients with ESD for EGCs, and severe atrophic gastritis assessed by pepsinogen was also a risk factor when H. pylori was not eradicated.
Prognostic Benefit of Additional Treatment After Endoscopic Submucosal Dissection for Esophageal Squamous Cell Carcinoma. 国際誌

So Takahashi, Waku Hatta, Kenta Watanabe, Tomoyuki Koike, Tomohiro Shimada, Takuto Hikichi, Yosuke Toya, Ippei Tanaka, Yusuke Onozato, Koichi Hamada, Daisuke Fukushi, Ko Watanabe, Shoichi Kayaba, Hirotaka Ito, Tatsuya Mikami, Tomoyuki Oikawa, Yasushi Takahashi, Yutaka Kondo, Tetsuro Yoshimura, Takeharu Shiroki, Ko Nagino, Norihiro Hanabata, Akira Funakubo, Dai Hirasawa, Tetsuya Ohira, Jun Nakamura, Tomohiro Nakamura, Naoki Nakaya, Takayuki Matsumoto, Shinsaku Fukuda, Atsushi Masamune, Katsunori Iijima

Digestive diseases and sciences　68　(5)　2050-2060　2023年5月

DOI： 10.1007/s10620-022-07746-8 　

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BACKGROUND: Although additional treatment is considered for patients with esophageal squamous cell carcinoma (ESCC) invading into the muscularis mucosa (pT1a-MM) or submucosa (pT1b-SM) after endoscopic submucosal dissection (ESD), the actual benefits of this method remain to be elucidated. AIMS: We aimed to evaluate the prognostic benefits of additional treatment in such patients. METHODS: Between 2006 and 2017, we enrolled patients with pT1a-MM/pT1b-SM ESCC after ESD at 21 institutions in Japan. Overall survival (OS) and disease-specific survival (DSS) were compared between the additional treatment and follow-up groups after propensity score matching, to reduce the bias of baseline characteristics. A subgroup analysis was performed according to the pathological findings: category A, pT1a-MM but negative for lymphovascular invasion (LVI) and vertical margin (VM); category B, tumor invasion into the submucosa ≤ 200 μm but negative for LVI and VM; category C, others. RESULTS: Of 593 patients with pT1a-MM/pT1b-SM ESCC after ESD, 101 matched pairs were extracted after propensity score matching. The OSs were similar between the additional treatment and follow-up groups (80.6% vs. 78.6% in 5 years; P = 0.972). In a subgroup analysis, the OS in the additional treatment group was significantly lower than that in the follow-up group (65.7% vs. 95.2% in 5 years; P = 0.037) in category A, whereas OS did not significantly differ in category C (76.8% vs. 69.5% in 5 years; P = 0.360). CONCLUSIONS: Additional treatment after ESD in patients with pT1a-MM/pT1b-SM ESCC was not associated with an improved prognosis.
10年間のコホート調査に基づく東日本大震災被災者における心理的苦痛の経年変化査読有り

臼倉瞳, 内海裕介, 瀬戸萌, 佐久間篤, 菅原由美, 國井泰人, 中谷直樹, 寳澤篤, 辻一郎, 富田博秋

精神神経学雑誌　125　(4)　266-274　2023年4月25日
出版者・発行元： (公社)日本精神神経学会
DOI： 10.57369/pnj.23-039 　

ISSN：0033-2658
White blood cell count profiles in anti-aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorder and anti-myelin oligodendrocyte glycoprotein antibody-associated disease. 国際誌

Tetsuya Akaishi, Tatsuro Misu, Kazuo Fujihara, Kumi Nakaya, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Kimihiko Kaneko, Toshiyuki Takahashi, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima, Atsushi Hozawa

Scientific reports　13　(1)　6481-6481　2023年4月20日

DOI： 10.1038/s41598-023-33827-3 　

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White blood cell (WBC) count profiles in anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD) and anti-myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are still unknown. This study evaluated the total WBC count, differential WBC counts, monocyte-to-lymphocyte ratio (MLR), and neutrophil-to-lymphocyte ratio (NLR) in patients with these diseases within three months from an attack before acute treatment or relapse prevention and compared the profiles with those in matched volunteers or in multiple sclerosis (MS) patients. AQP4-NMOSD patients (n = 13) had a higher neutrophil count (p = 0.0247), monocyte count (p = 0.0359), MLR (p = 0.0004), and NLR (p = 0.0037) and lower eosinophil (p = 0.0111) and basophil (p = 0.0283) counts than those of AQP4-NMOSD-matched volunteers (n = 65). Moreover, patients with MOGAD (n = 26) had a higher overall WBC count (p = 0.0001), neutrophil count (p < 0.0001), monocyte count (p = 0.0191), MLR (p = 0.0320), and NLR (p = 0.0002) than those of MOGAD-matched volunteers (n = 130). The three demyelinating diseases showed similar levels of the total and differential WBC counts; however, MOGAD and MS showed different structures in the hierarchical clustering and distributions on a two-dimensional canonical plot using differential WBC counts from the other three groups. WBC count profiles were similar in patients with MOGAD and MS but differed from profiles in matched volunteers or patients with AQP4-NMOSD.
Preventive Effects of Group Cognitive Behavioral Therapy in First-Year University Students at Risk for Depression: A Non-Randomized Controlled Trial. 国際誌

Sayaka Ogawa, Masaki Hayashida, Jun Tayama, Tatsuo Saigo, Naoki Nakaya, Toshimasa Sone, Masakazu Kobayashi, Peter Bernick, Atsushi Takeoka, Susumu Shirabe

Perceptual and motor skills　130　(2)　790-807　2023年4月

DOI： 10.1177/00315125231153778 　

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High scores on Harm Avoidance (HA) on Cloniger's Temperament and Character Inventory (TCI) have been identified as a risk factor for depression. Group cognitive-behavioral therapy (GCBT) has been found effective in preventing depression and improving depressive symptoms among university students. However, no randomized controlled trials of GCBT have been conducted with university students with high HA. Although we initiated a randomized controlled trial in this study, some participants submitted incomplete questionnaires at baseline interfering with assured randomization; therefore, we report this study as a non-randomized controlled trial. We evaluated whether a GCBT intervention would be effective at reducing HA and, thereby, preventing depression in university students with high HA. We performed final analysis of data on 59 participants in the intervention group and 60 in a control group. We used scores on the Beck Depression Inventory-II (BDI-II) as the primary outcome measure and analysis of covariance to assess group differences on mean BDI-II change scores before the intervention and at six months and one year after the intervention. The intervention group had lower BDI-II scores than the control group at six months after the intervention. GCBT may have facilitated cognitive modification in individuals with high HA, or GCBT may have fostered mutual modeling by group participants. Thus, GCBT may contribute to reducing depressive symptoms in university students with high HA, and associated risk for developing depression.
Association between lung function and hypertension and home hypertension in a Japanese population: the Tohoku Medical Megabank Community-Based Cohort Study. 国際誌

Masato Takase, Mitsuhiro Yamada, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

Journal of hypertension　41　(3)　443-452　2023年3月1日

DOI： 10.1097/HJH.0000000000003356 　

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BACKGROUND: Although several studies have shown an inverse association between lung function and hypertension, few studies have examined the association between lung function and hypertension among never-smokers, and no study has investigated the association between lung function and home hypertension. We investigated the associations between lung function and hypertension in a Japanese population. INDIVIDUALS AND METHODS: We conducted a cross-sectional study of 3728 men and 8795 women aged 20 years or older living in Miyagi Prefecture, Japan. Lung function was assessed using forced expiratory volume at 1 s (FEV1) and forced vital capacity (FVC), measured by spirometry. Hypertension was defined as a casual blood pressure at least 140/90 mmHg and/or self-reported treatment for hypertension. Home hypertension was defined as morning home blood pressure at least 135/85 mmHg and/or self-reported treatment for hypertension. Multivariate logistic regression models adjusted for potential confounders were used to assess the association between lung function and hypertension. RESULTS: The mean ages (±SD) of men and women were 60.1 (±14.0) years and 56.2 (±13.4) years, respectively, and 1994 (53.5%) men and 2992 (34.0%) women had hypertension. In the multivariable models, FEV1 and FVC were inversely associated with hypertension. Inverse associations between lung function and hypertension were observed even among never-smokers. Furthermore, reduced lung function was associated with higher prevalence of home hypertension in men and women. CONCLUSION: Reduced lung function was associated with higher prevalence of hypertension, independent of smoking status. Assessment of the lung function or blood pressure may be required in individuals with reduced lung function or hypertension.
Associations between the Combined Fat Mass Index and Fat-Free Mass Index with Carotid Intima-Media Thickness in a Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study.

Masato Takase, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Kichiya Suzuki, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

Journal of atherosclerosis and thrombosis　30　(3)　255-273　2023年3月1日

DOI： 10.5551/jat.63523 　

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AIM: Although many epidemiological studies have shown that obesity assessed by body mass index is associated with carotid intima-media thickness (cIMT), few studies have evaluated fat-free mass, which is a component of body composition. We investigated the associations between the combined fat mass index (FMI) and fat-free mass index (FFMI) with cIMT. METHODS: We conducted a cross-sectional study of 3,873 men and 9,112 women aged 20 years or older who lived in Miyagi prefecture, Japan. The FMI and FFMI were calculated as fat mass and fat-free mass divided by height squared, respectively. The indices were classified into sex-specific quartiles and were combined into 16 groups. The maximum common carotid artery was measured using high-resolution B-mode ultrasound. An analysis of covariance was used to assess associations between the combined FMI and FFMI with cIMT adjusted for age and smoking status. The linear trend test was conducted by stratifying the FMI and FFMI, scoring the categories from 1 (lowest) to 4 (highest), and entering the number as a continuous term in the regression model. RESULTS: In multivariable models, a higher FMI was not related to higher cIMT in men and women in most FFMI subgroups. Conversely, a higher FFMI was related to higher cIMT in all FMI subgroups (p＜0.001 for linear trend). CONCLUSIONS: FMI was not associated with cIMT in most FFMI subgroups. Conversely, FFMI was positively associated with cIMT independently of FMI.
Population Pharmacokinetics, Pharmacogenomics, and Adverse Events of Osimertinib and its Two Active Metabolites, AZ5104 and AZ7550, in Japanese Patients with Advanced Non-small Cell Lung Cancer: a Prospective Observational Study. 国際誌

Emi Ishikawa, Yuta Yokoyama, Haruna Chishima, Hidefumi Kasai, Ouki Kuniyoshi, Motonori Kimura, Jun Hakamata, Hideo Nakada, Naoya Suehiro, Naoki Nakaya, Hideo Nakajima, Shinnosuke Ikemura, Ichiro Kawada, Hiroyuki Yasuda, Hideki Terai, Aya Jibiki, Hitoshi Kawazoe, Kenzo Soejima, Hiroshi Muramatsu, Sayo Suzuki, Tomonori Nakamura

Investigational new drugs　41　(1)　122-133　2023年2月

DOI： 10.1007/s10637-023-01328-9 　

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BACKGROUND: Potential novel strategies for adverse event (AE) management of osimertinib therapy, including therapeutic drug monitoring and the use of biomarkers, have not yet been fully investigated. This study aimed to evaluate (1) the relationship between exposure to osimertinib, especially its active metabolites (AZ5104 and AZ7550), and AEs, and (2) the relationship between germline polymorphisms and AEs. METHODS: We conducted a prospective, longitudinal observational study of 53 patients with advanced non-small cell lung cancer receiving osimertinib therapy from February 2019 to April 2022. A population pharmacokinetic model was developed to estimate the area under the serum concentration-time curve from 0 to 24 h (AUC0-24) of osimertinib and its metabolites. Germline polymorphisms were analyzed using TaqMan® SNP genotyping and CycleavePCR® assays. RESULTS: There was a significant association between the AUC0-24 of AZ7550 and grade ≥ 2 paronychia (p = 0.043) or anorexia (p = 0.011) and between that of osimertinib or AZ5104 and grade ≥ 2 diarrhea (p = 0.026 and p = 0.049, respectively). Furthermore, the AUC0-24 of AZ5104 was significantly associated with any grade ≥ 2 AEs (p = 0.046). EGFR rs2293348 and rs4947492 were associated with severe AEs (p = 0.019 and p = 0.050, respectively), and ABCG2 rs2231137 and ABCB1 rs1128503 were associated with grade ≥ 2 AEs (p = 0.008 and p = 0.038, respectively). CONCLUSION: Higher exposures to osimertinib, AZ5104, and AZ7550 and polymorphisms in EGFR, ABCG2, and ABCB1 were related to higher severity of AEs; therefore, monitoring these may be beneficial for osimertinib AE management.
地域在住高齢者の自己報告による視覚障害と要介護発生との関連鶴ヶ谷プロジェクト

小幡紘輝, 鈴鴨よしみ, 宮武ミドリ, 永富良一, 小暮真奈, 中谷直樹, 寳澤篤, 出江紳一

Journal of Epidemiology　33　(Suppl.1)　149-149　2023年2月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
診察室非高血圧者における抑うつ気分と仮面高血圧の関連性の検討

時岡紗由理, 中谷直樹, 千葉一平, 中谷久美, 小暮真奈, 畑中里衣子, 菅野郁美, 小原拓, 栗山進一, 辻一郎

Journal of Epidemiology　33　(Suppl.1)　141-141　2023年2月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
BMI・飲酒・尿Na/K比と高血圧の関連における両親の高血圧既往の影響

平田匠, 小暮真奈, 畑中里衣子, 千葉一平, 中谷久美, 菅野郁美, 中村智洋, 小原拓, 中谷直樹, 栗山進一, 辻一郎, 寳澤篤

Journal of Epidemiology　33　(Suppl.1)　155-155　2023年2月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
脂肪量指数と除脂肪量指数の組み合わせと呼吸機能検査指標の関連

高瀬雅仁, 山田充啓, 中村智洋, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 布施昇男, 栗山進一, 辻一郎, 寳澤篤

Journal of Epidemiology　33　(Suppl.1)　155-155　2023年2月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
糖尿病指標と嗅覚機能の関連

佐竹芽久美, 菅野郁美, 佐藤守一, 今枝孝夫, 高梨昌樹, 早川和美, 中谷久美, 千葉一平, 小暮真奈, 畑中里衣子, 斉藤智, 中村智洋, 長神風二, 荻島創一, 布施昇男, 麦倉俊司, 栗山進一, 中谷直樹, 寳澤篤

Journal of Epidemiology　33　(Suppl.1)　156-156　2023年2月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
東北メディカル・メガバンク計画地域住民コホート調査(宮城)詳細二次調査の概要

中谷久美, 中谷直樹, 小暮真奈, 畑中里衣子, 千葉一平, 菅野郁美, 中村智洋, 小原拓, 宇留野晃, 布施昇男, 辻一郎, 栗山進一, 寳澤篤

Journal of Epidemiology　33　(Suppl.1)　173-173　2023年2月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
血清メタボロームと認知機能変化の関連 NILS-LSAの観察結果から

寳澤篤, 大塚礼, 張シュ, 菱沼英史, 元池育子, 三枝大輔, 中谷直樹, 小柴生造, 荒井秀典

Journal of Epidemiology　33　(Suppl.1)　87-87　2023年2月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
早期胃癌治療後の早期・後期死亡関連因子

尾形洋平, 八田和久, 大原祐樹, 小池智幸, 阿部寛子, 齊藤真弘, 金笑奕, 菅野武, 宇野要, 浅野直喜, 今谷晃, 山村明寛, 田中直樹, 亀井尚, 海野倫明, 中村智洋, 中谷直樹, 正宗淳

Gastroenterological Endoscopy　65　(2)　162,np1-np9　2023年2月
出版者・発行元： (一社)日本消化器内視鏡学会
DOI： 10.11280/gee.65.162 　

ISSN：0387-1207

eISSN：1884-5738
Design and Progress of Child Health Assessments at Community Support Centers in the Birth and Three-Generation Cohort Study of the Tohoku Medical Megabank Project.

Tomoko Kobayashi, Mika Kobayashi, Naoko Minegishi, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Tomomi Onuma, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Akira Uruno, Junichi Sugawara, Kichiya Suzuki, Eiichi N Kodama, Yohei Hamanaka, Naho Tsuchiya, Mana Kogure, Naoki Nakaya, Makiko Taira, Mika Sakurai-Yageta, Toru Tamahara, Junko Kawashima, Maki Goto, Akihito Otsuki, Ritsuko Shimizu, Soichi Ogishima, Hiroaki Hashizume, Fuji Nagami, Tomohiro Nakamura, Atsushi Hozawa, Tadao Kobayashi, Nobuo Fuse, Shinichi Kuriyama, Shigeo Kure, Masayuki Yamamoto

The Tohoku journal of experimental medicine　259　(2)　93-105　2023年1月20日

DOI： 10.1620/tjem.2022.J103 　

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The Tohoku Medical Megabank Project (TMM) has been conducting a birth and three-generation cohort study (the BirThree Cohort Study). We recruited 73,529 pregnant women and their family members for this cohort study, which included 23,143 newborns and 9,459 of their siblings. We designed and are in the process of conducting three-step health assessments for each newborn at approximately ages of 5, 10 and 16. These health assessments are administered at seven community support centers. Trained genome medical research coordinators conduct physical examinations of and collect biological specimens from each participant. The Sendai Children's Health Square has been established as the headquarters for these child health assessments and is utilized to accumulate knowledge that can facilitate the proper practice of child health assessments. We designed all the relevant health assessments facilities to allow parents and their children to participate in the health assessments concomitantly. Our centers serve as places where child participants and their parents can feel at ease as a result of the implementation of safety measures and child hospitality measures. The TMM BirThree Cohort Study is in the process of conducting strategically detailed health assessments and genome analysis, which can facilitate studies concerning the gene-environment interactions relevant to noncommunicable diseases. Through these operations, our study allows for a significant depth of data to be collected in terms of the number of biospecimens under study and the comprehensiveness of both basic and clinical data alongside relevant family information.
Chronic Diseases and Sociodemographic Characteristics Associated With Online Health Information Seeking and Using Social Networking Sites: Nationally Representative Cross-sectional Survey in Japan

Seigo Mitsutake, Yoshimitsu Takahashi, Aki Otsuki, Jun Umezawa, Akiko Yaguchi-Saito, Junko Saito, Maiko Fujimori, Taichi Shimazu, Maiko Fujimori, Masayo Hayakawa, Satoyo Hosono, Manami Inoue, Yuki Kaji, Kota Katanoda, Aya Kuchiba, Tomohiro Matsuda, Yutaka J. Matsuoka, Miyuki Odawara, Aki Otsuki, Junko Saito, Hirokazu Takahashi, Miyako Takahashi, Yosuke Uchitomi, Jun Umezawa, Otome Watanabe, Akiko Yaguchi-Saito, Itsuro Yoshimi, Taichi Shimazu, Gary L. Kreps, Naomi Sakurai, Takumi Momosaka, Miki Akiyama, Rina Miyawaki, Ryo Okubo, Rie Akamatsu, Yui Kawasaki, Kahori Fujisaki, Hirono Ishikawa, Runa Ogawa, Yoshiharu Fukuda, Haruhiko Imamura, Kumi Nakaya, Naoki Nakaya, Seigo Mitsutake, Hiroyuki Sasai

Journal of Medical Internet Research　25　2023年

DOI： 10.2196/44741 　

eISSN：1438-8871
Similarities in cardiometabolic risk factors among random male-female pairs: a large observational study in Japan. 国際誌

Naoki Nakaya, Kumi Nakaya, Naho Tsuchiya, Toshimasa Sone, Mana Kogure, Rieko Hatanaka, Ikumi Kanno, Hirohito Metoki, Taku Obara, Mami Ishikuro, Atsushi Hozawa, Shinichi Kuriyama

BMC public health　22　(1)　1978-1978　2022年10月28日

DOI： 10.1186/s12889-022-14348-6 　

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BACKGROUND: Previous observational studies have shown similarities in cardiometabolic risk factors between spouses. It is still possible that this result reflects the age similarity of spouses rather than environmental factors of spouses (e.g. cohabitation effect). To clarify the importance of mate cardiometabolic risk factors for similarity of environmental factors, it is necessary to examine whether they are observed in random male-female pairs while maintaining the age of the spousal pairs. This study aimed to determine whether the similarities found between spousal pairs for cardiometabolic risks were also observed between random male-female pairs. METHODS: This cross-sectional study included 5,391 spouse pairs from Japan; data were obtained from a large biobank study. For pairings, women of the same age were randomly shuffled to create new male-female pairs of the same age as that of the original spouse pairs. Similarities in cardiometabolic risk factors between the random male-female pairs were analysed using Pearson's correlation or age-adjusted logistic regression analyses. RESULTS: The mean ages of the men and women were 63.2 and 60.4 years, respectively. Almost all cardiometabolic risk factors similarities were not noted in cardiometabolic risk factors, including the continuous risk factors (anthropometric traits, blood pressure, glycated haemoglobin level, and lipid traits); lifestyle habits (smoking, drinking, and physical activity); or diseases (hypertension, type 2 diabetes mellitus, and metabolic syndrome) between the random male-female pairs. The age-adjusted correlation coefficients ranged from - 0.007 for body mass index to 0.071 for total cholesterol. The age-adjusted odds ratio (95% confidence interval) for current drinkers was 0.94 (0.81 - 1.09); hypertension, 1.07 (0.93 - 1.23); and type 2 diabetes mellitus, 1.08 (0.77 - 1.50). CONCLUSION: In this study, few similarities in cardiometabolic risk factors were noted among the random male-female pairs. As spouse pairs may share environmental factors, intervention strategies targeting lifestyle habits and preventing lifestyle-related diseases may be effective.
Decreased Expression of NRF2 Target Genes after Alcohol Exposure in the Background Esophageal Mucosa of Patients with Esophageal Squamous Cell Carcinoma.

Shusuke Toda, Waku Hatta, Kiyotaka Asanuma, Naoki Asano, Yoshitaka Ono, Hiroko Abe, Yohei Ogata, Masahiro Saito, Takeshi Kanno, Xiaoyi Jin, Kaname Uno, Tomoyuki Koike, Akira Imatani, Shin Hamada, Tomohiro Nakamura, Naoki Nakaya, Atsushi Masamune

The Tohoku journal of experimental medicine　258　(3)　195-206　2022年10月25日
出版者・発行元： Tohoku University Medical Press
DOI： 10.1620/tjem.2022.J077 　

ISSN：0040-8727

eISSN：1349-3329

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Patients with esophageal squamous cell carcinoma (ESCC) might have a specific mechanism for the carcinogenesis by alcohol consumption in the background esophageal mucosa, and nuclear factor erythroid 2-related factor 2 (NRF2), which plays a protective role against esophageal carcinogenesis, and barrier dysfunction might be associated with this phenomenon. This study aimed to confirm this hypothesis. Twenty patients with superficial ESCCs (ESCC patients) and 20 age- and sex-matched patients without ESCC (non-ESCC patients) were enrolled. Biopsy samples were obtained from non-neoplastic esophageal mucosa: one for histological evaluation, one for quantitative real-time polymerase chain reaction (PCR), and two for the mini-Ussing chamber system to measure transepithelial electrical resistance (TEER) and, thereafter, for PCR. The TEER after acetaldehyde or both acetaldehyde and ethanol exposure did not differ significantly between ESCC and non-ESCC patients. Unlike non-ESCC patients, mRNA levels of NRF2 target genes and claudin4 in ESCC patients tended to decrease after the exposure, with a significant difference between no exposure and both acetaldehyde and ethanol exposure in NRF2 target genes (p < 0.05). Furthermore, in ESCC patients, the decreased tendency of mRNA levels of NRF2 target genes after the exposure was more pronounced in high-risk states, such as aldehyde dehydrogenase 2 (ALDH2) Lys alleles (Glu/Lys + Lys/Lys), Lugol-voiding lesion grade C, and drinking history. In conclusion, the protective role of NRF2 against carcinogenesis from alcohol exposure might be disrupted in the background esophageal mucosa of ESCC patients, which might lead to a high incidence of metachronous ESCC.
Visualization of estimated prevalence of CES-D positivity accounting for background factors and AIS scores. 国際誌

Takashi Matsuyama, Akira Narita, Masaki Takanashi, Mana Kogure, Shuichi Sato, Tomohiro Nakamura, Hideo Nakane, Soichi Ogishima, Fuji Nagami, Naoki Nakaya, Kozo Tanno, Takao Imaeda, Atsushi Hozawa

Scientific reports　12　(1)　17656-17656　2022年10月21日

DOI： 10.1038/s41598-022-22266-1 　

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Development of methods for population screening is necessary to improve the efficiency of secondary prevention of diseases. Until now, a common cutoff has been used for all people in the data set. However, if big data for health information can be used to modify individual cutoffs according to background factors, it may avoid wasting medical resources. Here we show that the estimated prevalence of the Center for Epidemiologic Studies Depression Scale positivity can be visualized by a heatmap using background factors from epidemiological big data and scores from the Athens Insomnia Scale. We also show that cutoffs based on the estimated prevalence can be used to decrease the number of people screened without decreasing the number of prevalent cases detected. Since this method can be applied to the screening of different outcomes, we believe our work can contribute to the development of efficient screening methods for various diseases.
地域在住高齢者の予測努力肺活量と肺炎死の関連および筋力と血清総コレステロール値の影響

汐川菜々子, 岡崎達馬, 鈴鴨よしみ, 宮武ミドリ, 海老原覚, 小暮真奈, 中谷直樹, 寳澤篤, 出江紳一

The Japanese Journal of Rehabilitation Medicine　59　(秋季特別号)　S444-S444　2022年10月
出版者・発行元： (公社)日本リハビリテーション医学会
ISSN：1881-3526

eISSN：1881-8560
Five-Year Psychosocial Impact of Living in Postdisaster Prefabricated Temporary Housing. 国際誌

Tetsuya Akaishi, Tomomi Suzuki, Harumi Nemoto, Yusuke Utsumi, Moe Seto, Hitomi Usukura, Yasuto Kunii, Yumi Sugawara, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Atsushi Hozawa, Ichiro Tsuji, Tadashi Ishii, Hiroaki Tomita

Disaster medicine and public health preparedness　16　(5)　1966-1974　2022年10月

DOI： 10.1017/dmp.2021.214 　

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OBJECTIVE: This study aims to evaluate the long-term impact of living in postdisaster prefabricated temporary housing on social interaction activities and mental health status. METHODS: A total of 917 adult residents in a coastal town, whose residences were destroyed by the tsunami caused by the Great East Japan Earthquake (GEJE), were enrolled for the assessment held 5 y after the disaster. They answered questions about their experience and consequence of living in prefabricated temporary housing after the disaster. Their present scores on 5 types of self-reported measures regarding the psychosocial or psychiatric status and their present and recalled social interaction activities were cross-sectionally collected. RESULTS: A total of 587 (64.0%) participants had a history of living in prefabricated temporary housing, while the other 330 (36.0%) had not. The prevalence of social interaction activities significantly decreased after the GEJE. However, the experience of living in prefabricated temporary housing did not adversely affect the subsequent social interaction activities or mental conditions of the participants 5 y after the disaster. CONCLUSIONS: Living in postdisaster prefabricated temporary housing may not negatively impact subsequent psychosocial conditions or social interaction activities 5 y later.
Development of a method for walking step observation based on large-scale GPS data. 国際誌

Shohei Nagata, Tomoki Nakaya, Tomoya Hanibuchi, Naoki Nakaya, Atsushi Hozawa

International journal of health geographics　21　(1)　10-10　2022年9月7日

DOI： 10.1186/s12942-022-00312-5 　

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BACKGROUND: Widespread use of smartphones has enabled the continuous monitoring of people's movements and physical activity. Linking global positioning systems (GPS) data obtained via smartphone applications to physical activity data may allow for large-scale and retrospective evaluation of where and how much physical activity has increased or decreased due to environmental, social, or individual changes caused by policy interventions, disasters, and infectious disease outbreaks. However, little attention has been paid to the use of large-scale commercial GPS data for physical activity research due to limitations in data specifications, including limited personal attribute and physical activity information. Using GPS logs with step counts measured by a smartphone application, we developed a simple method for daily walking step estimation based on large-scale GPS data. METHODS: The samples of this study were users whose GPS logs were obtained in Sendai City, Miyagi Prefecture, Japan, during October 2019 (37,460 users, 36,059,000 logs), and some logs included information on daily step counts (731 users, 450,307 logs). The relationship between land use exposure and daily step counts in the activity space was modeled using the small-scale GPS logs with daily step counts. Furthermore, we visualized the geographic distribution of estimated step counts using a large set of GPS logs with no step count information. RESULTS: The estimated model showed positive relationships between visiting high-rise buildings, parks and public spaces, and railway areas and step counts, and negative relationships between low-rise buildings and factory areas and daily step counts. The estimated daily step counts tended to be higher in urban areas than in suburban areas. Decreased step counts were mitigated in areas close to train stations. In addition, a clear temporal drop in step counts was observed in the suburbs during heavy rainfall. CONCLUSIONS: The relationship between land use exposure and step counts observed in this study was consistent with previous findings, suggesting that the assessment of walking steps based on large-scale GPS logs is feasible. The methodology of this study can contribute to future policy interventions and public health measures by enabling the retrospective and large-scale observation of physical activity by walking.
東日本大震災による自宅の被害状況と高血圧治療中断との関連

畑中里衣子, 中谷直樹, 小暮真奈, 中谷久美, 千葉一平, 菅野郁美, 中村智洋, 後岡広太郎, 小原拓, 布施昇男, 栗山進一, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　81回　196-196　2022年9月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
過敏性腸症候群の有病に関連する要因の検討 TMM計画地域住民コホート調査

中谷久美, 中谷直樹, 永家聖, 小暮真奈, 畑中里衣子, 千葉一平, 菅野郁美, 小原拓, 中村智洋, 金澤素, 荻島創一, 栗山進一, 辻一郎, 寳澤篤, 福土審

日本公衆衛生学会総会抄録集　81回　201-201　2022年9月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
呼吸機能検査指標と高血圧有病との関連

高瀬雅仁, 山田充啓, 中村智洋, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 土屋菜歩, 平田匠, 布施昇男, 栗山進一, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　81回　202-202　2022年9月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
被災後住居形態と肝機能指標に関する横断研究

相場繁, 中谷直樹, 小暮真奈, 中谷久美, 畑中里衣子, 千葉一平, 菅野郁美, 栗山進一, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　81回　237-237　2022年9月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
生活習慣病の既往がない者における食事パターンと受診行動および医療費の関連

五十嵐有香, 小暮真奈, 鈴木寿則, 畑中里衣子, 中谷久美, 菅野郁美, 千葉一平, 中村智洋, 荻島創一, 中谷直樹, 栗山進一, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　81回　246-246　2022年9月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
健康診査への尿ナトリウム/カリウム比測定導入から見えてきたことと今後の展開

小暮真奈, 佐々木久美子, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 大川亜美, 黒川悦子, 永吉翔, 志賀利一, 清水友紀子, 牛田悠介, 上田宏幸, 中谷直樹, 寳澤篤

日本公衆衛生学会総会抄録集　81回　308-308　2022年9月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
握力および脚伸展力で測定した各筋力と生理学的データの関連

野路慶明, 畑中里衣子, 中谷直樹, 小暮真奈, 中谷久美, 千葉一平, 菅野郁美, 中村智洋, 布施昇男, 栗山進一, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　81回　431-431　2022年9月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
呼吸機能検査指標と高血圧有病との関連

高瀬雅仁, 山田充啓, 中村智洋, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 土屋菜歩, 平田匠, 布施昇男, 栗山進一, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　81回　202-202　2022年9月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
Issues of cancer care in people with mental disorders as perceived by cancer care providers: A quantitative questionnaire survey. 国際誌

Yuto Yamada, Masaki Fujiwara, Tsuyoshi Etoh, Riho Wada, Shinichiro Inoue, Masafumi Kodama, Yusaku Yoshimura, Shigeo Horii, Takanori Matsushita, Maiko Fujimori, Taichi Shimazu, Naoki Nakaya, Shiro Hinotsu, Masahiro Tabata, Kenji Tamura, Yosuke Uchitomi, Norihito Yamada, Masatoshi Inagaki

Psycho-oncology　31　(9)　1572-1580　2022年9月

DOI： 10.1002/pon.5992 　

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OBJECTIVES: To reduce cancer care disparities, this study aimed to clarify the difficulties in cancer care for people with mental disorders as perceived by cancer care providers. METHODS: Cancer care providers at 17 designated cancer hospitals in Japan were surveyed using mail questionnaires. Respondents were asked to rate 29 items related to difficulties or insufficiencies in cancer care for patients with mental disorders on a five-point Likert scale. We analyzed the proportion of respondents who answered 'difficult/insufficient' in each item. We also calculated the proportions of responders stratified according to the presence of psychiatric support systems within their hospitals. RESULTS: A total of 388 (58.4%) cancer care providers responded. Among the issues related to 'difficulties in diagnosing and treating cancer,' support for decision-making, assessment of treatment adherence, and assessment of physical symptoms were perceived as most difficult (73.5%-81.5% of respondents). Among the issues related to 'difficulties or insufficiencies in collaboration among multidisciplinary health care providers,' the issue of advance consultation and sharing information with the patient's primary psychiatric care provider was perceived as most difficult (52.2%). Among the issues related to 'insufficiencies of in-hospital and community medical systems,' education to provide reasonable accommodation was perceived as most insufficient (47.4%). The perceived difficulties of over half of the issues varied significantly between hospitals depending on the level of psychiatric support systems. CONCLUSIONS: This study clarified the difficulties of cancer care in patients with mental disorders as perceived by cancer care providers. Some issues may be resolved by psychiatric liaison teams. This article is protected by copyright. All rights reserved.
東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の進捗

中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 小原拓, 中村智洋, 宇留野晃, 布施昇男, 泉陽子, 丹野高三, 辻一郎, 栗山進一, 寳澤篤

東北公衆衛生学会誌　(71)　28-28　2022年7月
出版者・発行元：東北公衆衛生学会
ISSN：0915-549X
Relationship between the housing coldness/warmth evaluation by CASBEE Housing Health Checklist and psychological distress based on TMM Community-Based Cohort Study: a cross-sectional analysis. 国際誌

I Kanno, K Hasegawa, T Nakamura, M Kogure, F Itabashi, A Narita, N Tsuchiya, T Hirata, N Nakaya, J Sugawara, S Kuriyama, I Tsuji, S Kure, A Hozawa

Public health　208　98-104　2022年7月

DOI： 10.1016/j.puhe.2022.05.003 　

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OBJECTIVES: Previous studies have reported the relationship between housing environment and health, although due to cost and effort, it was difficult to conduct housing condition surveys on a large scale. The CASBEE Housing Health Checklist (the Checklist) made it possible to easily evaluate the housing condition from the resident's perspective. This study examined the relationship between housing coldness/warmth evaluation using the Checklist and psychological distress in a large-scale general Japanese population. STUDY DESIGN: A cross-sectional study. METHODS: We analysed data from 29,380 people aged ≥20 years who lived in Miyagi Prefecture, Japan. As an assessment of housing coldness/warmth, we used the Checklist. We classified participants' total scores on the Checklist related to coldness/warmth into quartiles. The Kessler 6 scale was used as an indicator of psychological distress. Multivariable logistic regression models were used to estimate the adjusted odds ratio (OR) and 95% confidence intervals (CIs). Adjusted OR and P-values for linear trends were calculated using the quartiles of the Checklists' score. RESULTS: Among participants in Q1 (i.e., poorer subjective house condition), the percentage of people with psychological distress was high. Compared to the highest quartile, Q1 showed poorer evaluation of housing coldness/warmth, and higher OR for psychological distress. The OR (95% CI) of psychological distress for Q3, Q2, and Q1 compared with Q4 were 1.93 (1.74-2.14), 2.82 (2.55-3.12), and 5.78 (5.25-6.35), respectively. CONCLUSIONS: Housing coldness/warmth evaluation was significantly related to psychological distress. This finding suggests that maintaining a comfortable thermal environment at home could be important for residents' mental health.
Correlation between TXNRD1/HO-1 expression and response to neoadjuvant chemoradiation therapy in patients with esophageal squamous cell carcinoma.

Ryujiro Akaishi, Fumiyoshi Fujishima, Hirotaka Ishida, Junichi Tsunokake, Takuro Yamauchi, Yusuke Gokon, Shunsuke Ueki, Toshiaki Fukutomi, Hiroshi Okamoto, Kai Takaya, Chiaki Sato, Yusuke Taniyama, Tomohiro Nakamura, Naoki Nakaya, Takashi Kamei, Hironobu Sasano

Esophagus : official journal of the Japan Esophageal Society　19　(3)　436-443　2022年7月

DOI： 10.1007/s10388-021-00904-3 　

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BACKGROUND: Thioredoxin reductase 1 (TXNRD1) and heme oxygenase-1 (HO-1) are both involved in the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and play key roles in antioxidant responses. In patients with esophageal squamous cell carcinoma (ESCC), the correlation between the expression of these two proteins and the therapeutic response to neoadjuvant chemoradiation therapy (NACRT), as well as the difference in their expression after chemoradiotherapy, remains unknown. METHODS: Proteins involved in the Nrf2 pathway were immunolocalized in carcinoma cells in ESCC patients on NACRT with 5-fluorouracil and cisplatin, followed by esophagectomy. The 8-hydroxydeoxyguanosine (8-OHdG) levels were used to quantify reactive oxygen species. The changes in immunoreactivity before and after NACRT (Δ) were assessed. RESULTS: Tumor reduction following NACRT was significantly attenuated in pre-therapeutic biopsy specimens associated with high HO-1 status. TXNRD1Δ, HO-1Δ, and 8-OHdGΔ were significantly different in the ineffective and effective groups. The overall survival was significantly lower in high Nrf2 and TXNRD1 groups. In addition, high TXNRD1 expression was an independent prognostic factor in the multivariate analysis of overall survival. CONCLUSIONS: The study findings indicate that HO-1 status in pre-therapeutic biopsy specimens could predict response to NACRT, and TXNRD1 status could predict overall survival of ESCC patients.
Patients' acceptability and implementation outcomes of a case management approach to encourage participation in colorectal cancer screening for people with schizophrenia: a qualitative secondary analysis of a mixed-method randomised clinical trial. 国際誌

Yuto Yamada, Masaki Fujiwara, Taichi Shimazu, Tsuyoshi Etoh, Masafumi Kodama, Ryuhei So, Takanori Matsushita, Yusaku Yoshimura, Shigeo Horii, Maiko Fujimori, Hirokazu Takahashi, Naoki Nakaya, Tempei Miyaji, Shiro Hinotsu, Keita Harada, Hiroyuki Okada, Yosuke Uchitomi, Norihito Yamada, Masatoshi Inagaki

BMJ open　12　(6)　e060621　2022年6月14日

DOI： 10.1136/bmjopen-2021-060621 　

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OBJECTIVES: We examined the efficacy of case management (CM) interventions to encourage participation in colorectal cancer screening for patients with schizophrenia. This study aimed to clarify patients' acceptability of the intervention and the helpful components of the intervention. Simultaneously, the study aimed to determine the acceptability, appropriateness and feasibility of the intervention from the perspective of psychiatric care providers. STUDY DESIGN AND SETTING: This study was a secondary qualitative analysis of a mixed-method randomised controlled trial that evaluated the efficacy of the CM approach to encourage participation in cancer screening for people with schizophrenia. The intervention comprised education and patient navigation for colorectal cancer screening. Interviews were conducted with patients who received the intervention and staff from two psychiatric hospitals in Japan who delivered the intervention. PARTICIPANTS: Of the 172 patients with schizophrenia who participated in the trial, 153 were included. In addition, three out of six providers were included. DATA COLLECTION AND ANALYSIS: Using a structured interview, the case manager asked participants about patient acceptability and the helpful components of the intervention. Content analysis was conducted for the responses obtained, and the number of responses was tabulated by two researchers. For the interviews with the providers, opinions obtained from verbatim transcripts were extracted and summarised. RESULTS: Forty-three of the 56 patients perceived that the intervention was acceptable. For the intervention component, inperson counselling with an explanation of the screening process by psychiatric care providers was most frequently reported by the patients as helpful (48 of the 68 respondents). Psychiatric care providers evaluated the intervention as acceptable, appropriate and easy to understand and administer. However, providing the intervention to all patients simultaneously was considered difficult with the current human resources. CONCLUSIONS: This study showed that the CM intervention was perceived as acceptable by patients and acceptable and appropriate by psychiatric care providers. TRIAL REGISTRATION NUMBER: UMIN000036017.
Review of Mental Health Consequences of the Great East Japan Earthquake through Long-Term Epidemiological Studies: The Shichigahama Health Promotion Project.

Yasuto Kunii, Hitomi Usukura, Yusuke Utsumi, Moe Seto, Yumiko Hamaie, Yumi Sugawara, Naoki Nakaya, Shinichi Kuriyama, Atsushi Hozawa, Ichiro Tsuji, Hiroaki Tomita

The Tohoku journal of experimental medicine　257　(2)　85-95　2022年6月4日

DOI： 10.1620/tjem.2022.J039 　

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After the Great East Japan Earthquake, Tohoku University began to provide mental health services during the acute phase of the disaster in cooperation with Shichigahama Town, one of the municipalities located in the coastal area of the Miyagi Prefecture that was severely damaged by the earthquake and tsunami; it continued to be providing long-term mental health activities, incorporating annual surveys for affected residents in the town for 10 years. Ten years of combination of surveys and outreach activities first depicted detailed longitudinal alterations in the mental health conditions of communities affected by a catastrophe. While posttraumatic stress reaction had recovered year by year after the year following the Great East Japan Earthquake, recovery from psychological distress retreated between 2014 and 2017, probably due to the relocation from temporal to eternal housing conditions. The annual cycles of assessment and provision of mental health support and promotion activities continued for 10 years can be an initial model for evidence-based, long-term post-disaster mental health and psychosocial support for the affected communities. Data regarding subsequent disasters should be collected in comparable ways, in order to improve the accuracy and usefulness of the accumulated data for planning and providing evidence-based post-disaster mental health and psychosocial support.
Development and validation of a new liquid chromatography-tandem mass spectrometry assay for the simultaneous quantification of afatinib, dacomitinib, osimertinib, and the active metabolites of osimertinib in human serum. 国際誌

Emi Ishikawa, Yuta Yokoyama, Haruna Chishima, Ouki Kuniyoshi, Itaru Sato, Naoki Nakaya, Hideo Nakajima, Motonori Kimura, Jun Hakamata, Naoya Suehiro, Hideo Nakada, Shinnosuke Ikemura, Aya Jibiki, Hitoshi Kawazoe, Hiroshi Muramatsu, Sayo Suzuki, Tomonori Nakamura

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences　1199　123245-123245　2022年5月30日

DOI： 10.1016/j.jchromb.2022.123245 　

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Reports on the therapeutic drug monitoring (TDM) of second- and third-generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) in non-small cell lung cancer patients are limited and are required to improve the safety of EGFR-TKI therapy. Some EGFR-TKIs have active metabolites with similar or higher potency compared with the parent compounds; thus, monitoring the parent compound as well as its active metabolites is essential for truly effective TDM. In this study, we developed and validated a method that simultaneously quantifies second- and third-generation EGFR-TKIs (afatinib, dacomitinib, and osimertinib) and the active metabolites of osimertinib, AZ5104 and AZ7550, in the human serum using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The clinical application of the method was also evaluated. The analytes were extracted from a 100 μL serum sample using a simple protein precipitation method and analyzed using LC-MS/MS. Excellent linearity of calibration curves was observed at ranges of 2.5-125.0 ng/mL for afatinib, 2.5-125.0 ng/mL for dacomitinib, 4.0-800.0 ng/mL for osimertinib, 1.0-125.0 ng/mL for AZ5104, and 2.5-125.0 ng/mL for AZ7550. The precision and accuracy were below 14.9% and within ± 14.9% of the nominal concentrations, respectively. The mean recovery was higher than 94.7% and the coefficient of variation (CV) was lower than 8.3%. The mean internal-standard normalized matrix factors ranged from 94.6 to 111.9%, and the CVs were lower than 9.7%. This analytical method met the acceptance criteria of the U.S. Food and Drug Administration guidelines. The method was also successfully applied to the analysis of 45 clinical samples; it supports the efficient and valuable analysis for TDM investigations of EGFR-TKIs.
Combined Associations of Liver Enzymes and Obesity With Diabetes Mellitus Prevalence: The Tohoku Medical Megabank Community-based Cohort Study.

Fumi Itabashi, Takumi Hirata, Mana Kogure, Akira Narita, Naho Tsuchiya, Tomohiro Nakamura, Naoki Nakaya, Ryohei Sasaki, Nobuyuki Takanashi, Kiyomi Sakata, Kozo Tanno, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

Journal of epidemiology　32　(5)　221-227　2022年5月5日

DOI： 10.2188/jea.JE20200384 　

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BACKGROUND: Alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) are enzymes associated with diabetes mellitus (DM) prevalence. However, limited information is available regarding the association of liver enzymes and DM consistently present in obese and non-obese individuals. We examined whether the combination of ALT and GGT enzymes is associated with the prevalence of DM regardless of obesity in a general Japanese population. METHODS: We conducted a cross-sectional study of 62,786 participants aged ≥20 years who lived in Miyagi and Iwate, Japan. We divided all the participants into eight groups according to the ALT level (low: <30 IU/L and high: ≥30 IU/L), GGT level (low: <50 IU/L and high: ≥50 IU/L), and the presence of obesity. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using multivariable logistic regression analysis, adjusting for potential confounders, to determine associations of the combination of ALT and GGT levels and obesity with DM prevalence. RESULTS: Overall, 6,008 participants (9.6%) had DM. Compared to non-obese individuals with low ALT and GGT levels, the participants with high ALT and GGT levels had high ORs for DM in both obese (OR 4.06; 95% CI, 3.61-4.56) and non-obese groups (OR 2.19; 95% CI, 1.89-2.52). The obese group had high ORs for DM, even at low ALT and GGT levels. CONCLUSION: High ALT and GGT levels are associated with DM prevalence in obese and non-obese participants. This finding suggests that correcting ALT and GGT levels and controlling obesity are important for the prevention of DM.
Association between urinary sodium-to-potassium ratio and home blood pressure and ambulatory blood pressure: the Ohasama study. 国際誌

Tomoko Muroya, Michihiro Satoh, Takahisa Murakami, Shingo Nakayama, Kei Asayama, Takuo Hirose, Yukako Tatsumi, Ryusuke Inoue, Megumi Tsubota-Utsugi, Azusa Hara, Mana Kogure, Naoki Nakaya, Kyoko Nomura, Masahiro Kikuya, Hirohito Metoki, Yutaka Imai, Atsushi Hozawa, Takayoshi Ohkubo

Journal of hypertension　40　(5)　862-869　2022年5月1日

DOI： 10.1097/HJH.0000000000003087 　

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OBJECTIVE: No studies have demonstrated the association between urinary sodium-to-potassium (Na/K) ratio and all out-of-office blood pressure (BP) [home morning and evening BP (self-measured at home), and 24-h, daytime, and night-time ambulatory BP] in the same cohort. We aimed to assess, which type of out-of-office BP is more strongly associated with urinary Na/K ratio in the general population. METHODS: This cross-sectional study was conducted in the general population of Ohasama, Japan. Home and ambulatory BP levels were measured, and 24-h urine samples were obtained from 875 participants (men, 25.5%; mean age, 60.1 years). The urinary Na/K ratio in the 24-h urine samples was calculated. RESULTS: The median (interquartile range) urinary Na/K ratio was 4.19 (3.36-5.26). Significant positive trends of home morning, home evening, 24-h, and daytime SBP were observed across quartiles of urinary Na/K ratio (trend P ≤ 0.041; adjusted mean values between Q1 and Q4 of urinary Na/K ratio: 121.0-125.5 mmHg for home morning, 120.1-123.8 mmHg for home evening, 121.6-123.4 mmHg for 24-h, 127.5-129.5 mmHg for daytime). Urinary Na/K ratio was not significantly associated with office or night-time SBP and nocturnal BP fall (trend P ≥ 0.13). In the model with both home morning or evening SBP and daytime SBP, only home SBP was significantly associated with urinary Na/K ratio (P ≤ 0.048 for home SBP). CONCLUSION: These findings suggest that urinary Na/K ratio might be more strongly associated with home BP than with 24-h and daytime BP but was not associated with night-time BP.
Consideration of the reference value and number of measurements of the urinary sodium-to-potassium ratio based on the prevalence of untreated home hypertension: TMM Cohort Study. 国際誌

Mana Kogure, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Kotaro Nochioka, Akira Narita, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Taku Obara, Michihiro Satoh, Hirohito Metoki, Ken Miyagawa, Hiroshi Koshimizu, Sho Nagayoshi, Akira Uruno, Masahiro Kikuya, Kichiya Suzuki, Naoki Nakaya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　45　(5)　866-875　2022年5月

DOI： 10.1038/s41440-021-00843-7 　

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The sodium-to-potassium (Na/K) ratio is known to be associated with blood pressure (BP). However, no reference value has been established since the urinary Na/K (uNa/K) ratio is known to have diurnal and day-to-day variations. Therefore, we investigated the number of days required to yield a better association between the morning uNa/K ratio and home BP (HBP) and determined a morning uNa/K ratio value that can be used as a reference value in participants who are not taking antihypertensive medication. This was a cross-sectional study using data from the Tohoku Medical Megabank Project Cohort Study. A total of 3122 participants borrowed HBP and uNa/K ratio monitors for 10 consecutive days. We assessed the relationship between the morning uNa/K ratio from 1 day to 10 days and home hypertension (HBP ≥ 135/85 mmHg) using multiple logistic regression models. Although a 1-day measurement of the morning uNa/K ratio was positively associated with home hypertension, multiple measurements of the morning uNa/K ratio were strongly related to home hypertension. The average morning uNa/K ratio was relatively stable after 3 days (adjusted odds ratio of home hypertension per unit increase in the uNa/K ratio for more than 3 days: 1.19-1.23). In conclusion, there was no threshold for the uNa/K ratio, and the morning uNa/K ratio was linearly associated with home hypertension. The Na/K ratio 2.0 calculated from the Dietary Reference Intakes for Japanese might be a good indication. Regarding the stability of the association between the morning uNa/K ratio and BP, more than 3 days of measurements is desirable.
Association between fat mass index, fat-free mass index and hemoglobin A1c in a Japanese population: The Tohoku Medical Megabank Community-based Cohort Study.

Masato Takase, Tomohiro Nakamura, Takumi Hirata, Naho Tsuchiya, Mana Kogure, Fumi Itabashi, Naoki Nakaya, Yohei Hamanaka, Junichi Sugawara, Kichiya Suzuki, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

Journal of diabetes investigation　13　(5)　858-867　2022年5月

DOI： 10.1111/jdi.13729 　

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AIMS/INTRODUCTION: Fat mass and fat-free mass affect glycated hemoglobin A1c (HbA1c) levels and blood glucose levels, respectively. The aim of the present study was to examine the association between fat mass index and fat-free mass index with HbA1c. MATERIALS AND METHODS: We conducted a cross-sectional study that included 3,731 men and 9,191 women aged 20 years or older, living in Miyagi Prefecture, Japan, who were not treated for diabetes. The fat mass index and fat-free mass index were calculated as fat mass and fat-free mass divided by the height squared, respectively. The indices were classified into sex-specific quartiles and combined into 16 groups. An ANCOVA was used to assess associations between the combined fat mass index and fat-free mass index with HbA1c adjusted for potential confounder. The linear trend test was conducted by stratifying the fat mass index and fat free mass index, entering the number as a continuous term in the regression model. RESULTS: In multivariable models, a higher fat mass index was related to higher HbA1c levels in men and women in all fat-free mass index subgroups (P<0.001 for linear trend). When we excluded the participants who had been pointed out to have diabetes, fat-free mass index was also related to higher HbA1c levels in most fat mass index subgroups (P<0.05 for linear trend). CONCLUSIONS: Fat mass index was positively related to HbA1c levels. Fat free mass index was also related to HbA1c levels when we excluded participants who had been pointed out to have diabetes.
Predictors of early and late mortality after the treatment for early gastric cancers. 国際誌

Yohei Ogata, Waku Hatta, Yuki Ohara, Tomoyuki Koike, Hiroko Abe, Masahiro Saito, Xiaoyi Jin, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Akihiro Yamamura, Naoki Tanaka, Takashi Kamei, Michiaki Unno, Tomohiro Nakamura, Naoki Nakaya, Atsushi Masamune

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society　34　(4)　816-825　2022年5月

DOI： 10.1111/den.14172 　

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OBJECTIVES: Although many patients with early gastric cancers (EGCs) die of non-gastric cancer-related causes, the association of the risk categories of lymph node metastasis (LNM) with all-cause mortality remains unclear. We aimed to clarify the predictors of early and late mortality, separately. METHODS: Patients with endoscopic resection or gastrectomy for EGCs between 2003 and 2017 were retrospectively enrolled. We analyzed predictors for early and late mortality, including risk categories of LNM, treatment method, and nine non-cancer-related indices, separately, with a cut-off value of three years. RESULTS: We enrolled 1,439 patients with a median follow-up period of 79 months. The five-year overall survival rate was 86.8%. In the multivariate Cox analysis, the most important predictors for early and late mortality were age ≥ 85 years [hazard ratio (HR), 2.88 and 4.54, respectively] and Eastern Cooperative Oncology Group Performance Status ≥ 2 (HR, 3.00 and 4.19, respectively). Charlson comorbidity index ≥ 2 (HR, 2.76 and 1.99, respectively), American Society of Anesthesiologists Physical Status ≥ 3 (HR, 2.35 and 1.79, respectively), and C-reactive protein/albumin ratio ≥ 0.028 (HR, 2.30 and 1.58, respectively) were also predictors for both early and late mortality. Male (HR, 2.26), intermediate- (HR, 2.12)/high-risk (HR, 1.85) of LNM in eCura system, and sarcopenia evaluated by the psoas muscle mass index (HR, 1.70) were predictors for early mortality. CONCLUSION: The combined assessment of multiple predictors might help to predict early and/or late mortality in patients with EGCs. The eCura system was associated with early mortality.
Olfactomedin 2 deficiency protects against diet-induced obesity. 国際誌

Ismael González-García, Óscar Freire-Agulleiro, Naoki Nakaya, Francisco J Ortega, Pablo Garrido-Gil, Laura Liñares-Pose, Johan Fernø, José Luis Labandeira-Garcia, Carlos Diéguez, Afia Sultana, Stanislav I Tomarev, José Manuel Fernández-Real, Miguel López

Metabolism: clinical and experimental　129　155122-155122　2022年4月

DOI： 10.1016/j.metabol.2021.155122 　

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BACKGROUND AND AIMS: Olfactomedin 2 (OLFM2; also known as noelin 2) is a pleiotropic protein that plays a major role in olfaction and Olfm2 null mice exhibit reduced olfactory sensitivity, as well as abnormal motor coordination and anxiety-related behavior. Here, we investigated the possible metabolic role of OLFM2. METHODS: Olfm2 null mice were metabolically phenotyped. Virogenetic modulation of central OLFM2 was also performed. RESULTS: Our data showed that, the global lack of OLFM2 in mice promoted anorexia and increased energy expenditure due to elevated brown adipose tissue (BAT) thermogenesis and browning of white adipose tissue (WAT). This phenotype led to resistance to high fat diet (HFD)-induced obesity. Notably, virogenetic overexpression of Olfm2 in the lateral hypothalamic area (LHA) induced weight gain associated with decreased BAT thermogenesis. CONCLUSION: Overall, this evidence first identifies central OLFM2 as a new molecular actor in the regulation of whole-body energy homeostasis.
統合失調症患者に対するがん検診勧奨法の質的評価混合研究法を用いた無作為化比較試験の二次解析

山田裕士, 藤原雅樹, 島津太一, 江藤剛, 児玉匡史, 宋龍平, 松下貴紀, 吉村優作, 堀井茂男, 藤森麻衣子, 高橋宏和, 中谷直樹, 宮路天平, 樋之津史郎, 原田馨太, 岡田裕之, 内富庸介, 山田了士, 稲垣正俊

精神神経学雑誌　124　(4付録)　S-373　2022年4月
出版者・発行元： (公社)日本精神神経学会
ISSN：0033-2658
精神科臨床場面における多職種協働によるがん検診の受診勧奨法のランダム化比較試験

藤原雅樹, 山田裕士, 島津太一, 児玉匡史, 宋龍平, 松下貴紀, 吉村優作, 堀井茂男, 藤森麻衣子, 高橋宏和, 中谷直樹, 掛田恭子, 宮路天平, 樋之津史郎, 原田馨太, 岡田裕之, 内富庸介, 山田了士, 稲垣正俊

精神神経学雑誌　124　(4付録)　S-643　2022年4月
出版者・発行元： (公社)日本精神神経学会
ISSN：0033-2658
Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan: The Tohoku Medical Megabank Organization Eye Study. 国際誌

Nobuo Fuse, Miyuki Sakurai, Ikuko N Motoike, Kaname Kojima, Takako Takai-Igarashi, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Akiko Miyazawa, Kei Homma, Keisuke Ido, Makiko Taira, Tomoko Kobayashi, Ritsuko Shimizu, Akira Uruno, Eiichi N Kodama, Kichiya Suzuki, Yohei Hamanaka, Hiroaki Tomita, Junichi Sugawara, Yoichi Suzuki, Fuji Nagami, Soichi Ogishima, Fumiki Katsuoka, Naoko Minegishi, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Yaegashi, Shigeo Kure, Kengo Kinoshita, Masayuki Yamamoto

Ophthalmology science　2　(1)　100113-100113　2022年3月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.xops.2022.100113 　

ISSN：2666-9145

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Purpose: To elucidate the differences in ocular biometric parameters by generation and gender and to identify axial length (AL)-associated genetic variants in Japanese individuals, we analyzed Tohoku Medical Megabank Organization (ToMMo) Eye Study data. Design: We designed the ToMMo Eye Study, examined AL variations, and conducted genome-wide association studies (GWASs). Participants: In total, 33 483 participants aged > 18 years who were recruited into the community-based cohort (CommCohort) and the birth and three-generation cohort (BirThree Cohort) of the ToMMo Eye Study were examined. Methods: Each participant was screened with an interview, ophthalmic examinations, and a microarray analysis. The GWASs were performed in 22 379 participants in the CommCohort (discovery stage) and 11 104 participants in the BirThree Cohort (replication stage). We evaluated the associations of single nucleotide polymorphisms (SNPs) with AL using a genome-wide significance threshold (5 × 10-8) in each stage of the study and in the subsequent meta-analysis. Main Outcome Measures: We identified the association of SNPs with AL and distributions of AL in right and left eyes and individuals of different sexes and ages. Results: In the discovery stage, the mean AL of the right eye (23.99 mm) was significantly greater than that of the left eye (23.95 mm). This difference was reproducible across sexes and ages. The GWASs revealed 703 and 215 AL-associated SNPs with genome-wide significance in the discovery and validation stages, respectively, and many of the SNPs in the discovery stage were replicated in the validation stage. Validated SNPs and their associated loci were meta-analyzed for statistical significance (P < 5 × 10-8). This study identified 1478 SNPs spread over 31 loci. Of the 31 loci, 5 are known AL loci, 15 are known refractive-error loci, 4 are known corneal-curvature loci, and 7 loci are newly identified loci that are not known to be associated with AL. Of note, some of them shared functional relationships with previously identified loci. Conclusions: Our large-scale GWASs exploiting ToMMo Eye Study data identified 31 loci linked to variations in AL, 7 of which are newly reported in this article. The results revealed genetic heterogeneity and similarity in SNPs related to ethnic variations in AL.
HO-1 in lymph node metastasis predicted overall survival in patients with esophageal squamous cell carcinoma receiving neoadjuvant chemoradiation therapy. 国際誌

Ryujiro Akaishi, Fumiyoshi Fujishima, Hirotaka Ishida, Junichi Tsunokake, Takuro Yamauchi, Yusuke Gokon, Shunsuke Ueki, Toshiaki Fukutomi, Hiroshi Okamoto, Kai Takaya, Chiaki Sato, Yusuke Taniyama, Tomohiro Nakamura, Naoki Nakaya, Takashi Kamei, Hironobu Sasano

Cancer reports (Hoboken, N.J.)　5　(3)　e1477　2022年3月

DOI： 10.1002/cnr2.1477 　

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BACKGROUND: Lymph node metastasis is one of the pivotal factors of the clinical outcomes of patients with esophageal cancer receiving neoadjuvant chemoradiation therapy (NACRT). Both the nuclear factor-erythroid 2-related factor 2 (Nrf2) signaling pathway and heme oxygenase-1 (HO-1) are frequently upregulated in various human malignancies and associated with resistance to chemoradiation therapy, subsequently resulting in adverse clinical outcomes. However, the Nrf2 and HO-1 status in lymph node metastasis and their differences between primary and metastatic lesions are unknown. AIMS: To examine the levels of Nrf2 signaling proteins and HO-1 in primary and metastatic lesions of patients with esophageal squamous cell carcinoma using immunohistochemistry. METHODS AND RESULTS: We immunolocalized Nrf2 signaling proteins in 69 patients with lymph node metastases, who received NACRT with 5-fluorouracil and cisplatin before esophagectomy. We also compared the findings between primary and metastatic lesions. Residual lymph node metastases were detected in 30 patients and among them, both primary and metastatic lesions were available for evaluation in 25 patients. Subsequently, we correlated the results with patients' survival. Nrf2, HO-1, and the Ki-67 labeling index were all significantly lower in the patients with lymph node metastases than in those with primary tumors. Carcinoma cells with high HO-1 levels were significantly associated with pathological resistance to NACRT. These results suggested that overall and disease-free survival of esophageal squamous cell carcinoma were significantly associated with both pN2 and high HO-1 levels, respectively. CONCLUSIONS: Protein expression in the Nrf2 pathway was significantly lower in patients with lymph node metastases than in those with primary lesions. HO-1 levels in lymph node metastases could be used to predict the eventual clinical outcome of patients with esophageal cancer receiving NACRT.
Somatostatin Receptor 2 Expression Profiles and Their Correlation with the Efficacy of Somatostatin Analogues in Gastrointestinal Neuroendocrine Tumors. 国際誌

Hirofumi Watanabe, Fumiyoshi Fujishima, Izumi Komoto, Masayuki Imamura, Susumu Hijioka, Kazuo Hara, Yasushi Yatabe, Atsushi Kudo, Toshihiko Masui, Takahiro Tsuchikawa, Kazuhiro Sakamoto, Hisashi Shiga, Tomohiro Nakamura, Naoki Nakaya, Fuyuhiko Motoi, Michiaki Unno, Hironobu Sasano

Cancers　14　(3)　2022年2月2日

DOI： 10.3390/cancers14030775 　

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Somatostatin analogues (SSAs) are widely used to treat gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Somatostatin receptor 2 (SSTR2) immunoreactivity serves as a predictive marker of the therapeutic efficacy of SSAs in pancreatic NETs. However, SSTR2 expression profiles in tumor cells and their association with the therapeutic efficacy of SSAs remains virtually unknown in gastrointestinal NETs (GI-NETs). Therefore, we evaluated the association between SSTR2 immunoreactivity and embryological origin and proliferative activity in 132 resected surgical tissues of GI-NETs. The correlation between SSAs' therapeutic efficacy and SSTR2 immunoreactivity was evaluated in 14 GI-NETs treated with SSAs. SSTR2 immunoreactivity was evaluated using Volante scores, immunoreactive scores, and digital image analysis (DIA). SSTR2 immunoreactivity was significantly negatively and positively correlated with the Ki-67 labeling index in foregut and hindgut NETs, respectively. In the normal mucosa, neuroendocrine cells in the rectum had significantly lower positive rates of SSTR2 than those in the stomach and duodenum. SSTR2 expression profiles in GI-NETs could differ by primary sites, while the difference of those between foregut and hindgut NETs might be derived from the SSTR2 status of normal neuroendocrine cell counterparts. In addition, DIA could provide a good alternative for predicting response to SSAs in evaluating SSTR2 immunoreactivity of GI-NETs.
White blood cell count profile in patients with physical complaints without known causes. 国際誌

Tetsuya Akaishi, Tadashi Ishii, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Masashi Aoki, Atsushi Hozawa

SAGE open medicine　10　20503121221105328-20503121221105328　2022年

DOI： 10.1177/20503121221105328 　

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OBJECTIVES: The aim of this study was to search for routine blood test biomarkers in patients with physical symptoms but without a diagnosis after comprehensive routine screening diagnostic examinations. METHODS: A total of 228 adults aged < 65 years who presented with physical complaints without known causes after comprehensive screening diagnostic examinations and 228 age- and sex-matched healthy controls without physical complaints were enrolled. The blood cell count data at the first hospital visit were compared between these groups. RESULTS: Total white blood cell (p = 0.2143), red blood cell (p = 0.8954), and platelet (p = 0.7716) counts did not differ between the groups. The monocyte count (p = 0.0014) and resultant monocyte-to-lymphocyte ratio (p < 0.0001) were higher in the symptomatic group, while the other white blood cell subtypes did not differ significantly between the two groups. In the symptomatic group, patients with a monocyte-to-lymphocyte ratio > 0.25 were likely to have unexplained nonfocal physical symptoms (p < 0.0001). The characteristic findings included fatigability (p < 0.0001), prolonged slight fever (p = 0.0005), and widespread pain (p < 0.0001). The monocyte-to-lymphocyte ratio level was correlated with the proportion of patients with unexplained nonfocal symptoms. CONCLUSION: The blood cell count profile was largely the same between healthy individuals and patients with unexplained physical symptoms. However, patients with unexplained nonfocal physical complaints were likely to show an elevated monocyte-to-lymphocyte ratio, typically > 0.25.
地域および職域の健康診査に尿Na/K比測定を導入して見えてきたこと健診機関とのタイアップ

小暮真奈, 佐々木久美子, 畑中里衣子, 菅野郁美, 板橋芙美, 黒川悦子, 大川亜美, 宮川健, 永吉翔, 牛田悠介, 清水友紀子, 上田宏幸, 土屋菜歩, 中谷直樹, 寳澤篤

総合健診　49　(1)　205-205　2022年1月
出版者・発行元： (一社)日本総合健診医学会
ISSN：1347-0086

eISSN：1884-4103
脂肪量指数および除脂肪量指数の組み合わせと頸動脈内膜中膜複合体厚(IMT)の肥厚との関連

高瀬雅仁, 中村智洋, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 菅野郁美, 土屋菜歩, 平田匠, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

Journal of Epidemiology　32　(Suppl.1)　126-126　2022年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
脂肪量指数および除脂肪量指数の組み合わせと頸動脈内膜中膜複合体厚(IMT)の肥厚との関連

高瀬雅仁, 中村智洋, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 菅野郁美, 土屋菜歩, 平田匠, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

Journal of Epidemiology　32　(Suppl.1)　126-126　2022年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
The return of individual genomic results to research participants: design and pilot study of Tohoku Medical Megabank Project. 国際誌

Hiroshi Kawame, Akimune Fukushima, Nobuo Fuse, Fuji Nagami, Yoichi Suzuki, Mika Sakurai-Yageta, Jun Yasuda, Yumi Yamaguchi-Kabata, Kengo Kinoshita, Soichi Ogishima, Takako Takai, Shinichi Kuriyama, Atsushi Hozawa, Naoki Nakaya, Tomohiro Nakamura, Naoko Minegishi, Junichi Sugawara, Kichiya Suzuki, Hiroaki Tomita, Akira Uruno, Tomoko Kobayashi, Yayoi Aizawa, Tomoharu Tokutomi, Kayono Yamamoto, Kinuko Ohneda, Shigeo Kure, Yoko Aoki, Hideki Katagiri, Yasushi Ishigaki, Shojiro Sawada, Makoto Sasaki, Masayuki Yamamoto

Journal of human genetics　67　(1)　9-17　2022年1月

DOI： 10.1038/s10038-021-00952-8 　

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Certain large genome cohort studies attempt to return the individual genomic results to the participants; however, the implementation process and psychosocial impacts remain largely unknown. The Tohoku Medical Megabank Project has conducted large genome cohort studies of general residents. To implement the disclosure of individual genomic results, we extracted the potential challenges and obstacles. Major challenges include the determination of genes/disorders based on the current medical system in Japan, the storage of results, prevention of misunderstanding, and collaboration of medical professionals. To overcome these challenges, we plan to conduct multilayer pilot studies, which deal with different disorders/genes. We finally chose familial hypercholesterolemia (FH) as a target disease for the first pilot study. Of the 665 eligible candidates, 33.5% were interested in the pilot study and provided consent after an educational "genetics workshop" on the basic genetics and medical facts of FH. The genetics professionals disclosed the results to the participants. All positive participants were referred to medical care, and a serial questionnaire revealed no significant psychosocial distress after the disclosure. Return of genomic results to research participants was implemented using a well-prepared protocol. To further elucidate the impact of different disorders, we will perform multilayer pilot studies with different disorders, including actionable pharmacogenomics and hereditary tumor syndromes.
dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project. 国際誌

Soichi Ogishima, Satoshi Nagaie, Satoshi Mizuno, Ryosuke Ishiwata, Keita Iida, Kazuro Shimokawa, Takako Takai-Igarashi, Naoki Nakamura, Sachiko Nagase, Tomohiro Nakamura, Naho Tsuchiya, Naoki Nakaya, Keiko Murakami, Fumihiko Ueno, Tomomi Onuma, Mami Ishikuro, Taku Obara, Shunji Mugikura, Hiroaki Tomita, Akira Uruno, Tomoko Kobayashi, Akito Tsuboi, Shu Tadaka, Fumiki Katsuoka, Akira Narita, Mika Sakurai, Satoshi Makino, Gen Tamiya, Yuichi Aoki, Ritsuko Shimizu, Ikuko N Motoike, Seizo Koshiba, Naoko Minegishi, Kazuki Kumada, Takahiro Nobukuni, Kichiya Suzuki, Inaho Danjoh, Fuji Nagami, Kozo Tanno, Hideki Ohmomo, Koichi Asahi, Atsushi Shimizu, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Fuse, Teiji Tominaga, Shigeo Kure, Nobuo Yaegashi, Kengo Kinoshita, Makoto Sasaki, Hiroshi Tanaka, Masayuki Yamamoto

Human genome variation　8　(1)　44-44　2021年12月10日

DOI： 10.1038/s41439-021-00175-5 　

eISSN：2054-345X
The prevalence of current smokers and alcohol drinkers among cancer survivors and subjects with no history of cancer among participants in a community-based cardiometabolic screening program in Miyagi prefecture, Japan: a comparison with nationally representative surveys in other countries. 国際誌

Yuka Nishimoto, Yoshitaka Tsubono, Mana Kogure, Tomohiro Nakamura, Fumi Itabashi, Naho Tsuchiya, Naoki Nakaya, Kozo Tanno, Junichi Sugawara, Shinichi Kuriyama, Shigeo Kure, Ichiro Tsuji, Atsushi Hozawa

Cancer medicine　10　(24)　9000-9011　2021年12月1日

DOI： 10.1002/cam4.4364 　

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BACKGROUND: We determined the prevalence of current cigarette smokers and alcohol drinkers among cancer survivors and subjects with no history of cancer in Japan and compared the findings with nationally representative studies in other countries. METHODS: We conducted a cross-sectional study of baseline data from a prospective cohort study. A self-administered questionnaire was surveyed during 2013-2015 with residents aged ≥20 years attending a community-based cardiometabolic screening program in Miyagi prefecture in north-eastern Japan. Subjects with past cancer histories were classified as cancer survivors. Sex-specific, age-standardized prevalence of current smokers, and drinkers were calculated. Age-adjusted prevalence ratios (PRs: the cancer survivors' rate divided by the rate of subjects with no history of cancer) and 95% confidence intervals (CIs) were estimated with log-binomial regressions. RESULTS: 36,786 subjects, including 2760 cancer survivors, responded and provided usable information (58.9% of recruited subjects). For men, the age-standardized prevalence of current smokers and drinkers among survivors was 18.8% and 74.4%, respectively, with an age-adjusted PR (95%CI) of 0.76 (0.66-0.86, p < 0.001) and 0.95 (0.91-0.98, p = 0.002), respectively. For women, the figures were 6.1%, 37.9%, 0.84 (0.67-1.06, p = 0.138) and 0.96 (0.90-1.03, p = 0.313), respectively. The U.S., the U.K, and Australian studies generally showed no substantially lower prevalence of current smokers or drinkers in survivors than in subjects with no history of cancer (PR ≥ 0.75), while Korean studies did (PR < 0.75). CONCLUSIONS: A considerable proportion of Japanese cancer survivors, especially men, remained currently smoking and drinking. Consistent with Western studies, the rates were not substantially lower than those among subjects with no history of cancer.
The association between psychological distress and risk of incident functional disability in elderly survivors after the Great East Japan Earthquake: The mediating effect of lifestyle and bodily pain. 国際誌

Toshimasa Sone, Yumi Sugawara, Fumiya Tanji, Naoki Nakaya, Hiroaki Tomita, Ichiro Tsuji

Journal of affective disorders　295　552-558　2021年12月1日

DOI： 10.1016/j.jad.2021.08.068 　

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BACKGROUND: We previously reported that psychological distress was associated with an increased risk of functional disability. However, the mechanism of the association remains unclear. Our aim was to estimate the mediating effect of lifestyle and bodily pain on the association among elderly survivors after the Great East Japan Earthquake. METHODS: The study population comprised 1037 residents aged ≥ 65 years. The baseline surveys (exposure and mediators) were conducted in 2011. We classified participants into three categories according to their Kessler 6 score (low: 0-9, moderate: 10-12, and high: 13-24) and defined functional disability as certification for long-term care insurance in Japan. The Cox proportional hazards model was used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for incident functional disability according to Kessler 6 categories and explored the mediating effects of lifestyle and bodily pain on the association. RESULTS: During approximately 8 years of follow-up, we documented 271 incident cases of functional disability. Compared with those in the low distress group, the multivariate adjusted HR for incident functional disability was 1.95 (95% CI 1.21-3.13) for those in the high distress group. Time spent walking, going out, and bodily pain significantly mediated the association between psychological distress and incident functional disability by 10.2%, 10.5%, and 10.3% for the high distress group, respectively. LIMITATIONS: We did not consider unmeasured confounders and use of appropriate medication. CONCLUSIONS: The evaluation and treatment of bodily pain as well as promotion of active lifestyle would be important for preventing disability among disaster survivors.
Cancer care for people with mental disorders: A qualitative survey among cancer care and psychiatric care professionals in Japan. 国際誌

Tsuyoshi Etoh, Masaki Fujiwara, Yuto Yamada, Riho Wada, Yuji Higuchi, Shinichiro Inoue, Masafumi Kodama, Takanori Matsushita, Yusaku Yoshimura, Shigeo Horii, Maiko Fujimori, Kyoko Kakeda, Taichi Shimazu, Naoki Nakaya, Masahiro Tabata, Yosuke Uchitomi, Norihito Yamada, Masatoshi Inagaki

Psycho-oncology　30　(12)　2060-2066　2021年12月

DOI： 10.1002/pon.5780 　

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OBJECTIVE: It is widely assumed that there are multiple levels (from individual to policy level) of problems involving disparities in cancer care for people with mental disorders. However, few studies have comprehensively investigated issues as perceived by medical professionals. The purpose of the present study was to identify a wide range of issues in cancer care for people with mental disorders and offer corresponding solutions for both cancer care professionals and psychiatric care professionals. METHODS: We distributed open-ended questionnaires to 754 healthcare professionals in various medical facilities, including designated cancer hospitals, psychiatric hospitals, and other local healthcare/welfare facilities. Participants were asked to describe issues in cancer care for people with mental disorders. RESULTS: Of the 754 recruited professionals, 439 (58.2%) responded to the questionnaire. Sixty-one issues were extracted and categorized into 10 categories: patient factors; isolation and lack of support; obstacles to transport; socioeconomic factors; attitudes of psychiatric professionals; medical system of psychiatric hospitals; attitudes of cancer care professionals; medical system of designated cancer hospitals; regional cancer medical systems; and lack of coordination among multidisciplinary healthcare professionals. Forty-eight specific solutions were summarized into 12 goals. CONCLUSIONS: The present study widely identified issues causing disparities in cancer care for patients with mental disorders. We found that the issues extended from the patient level to the public-policy level. Our findings suggest the need for a multidisciplinary approach that includes both cancer and psychiatric care professionals to address the gap in cancer care for people with mental disorders.
White blood cell count profiles in multiple sclerosis during attacks before the initiation of acute and chronic treatments. 国際誌

Tetsuya Akaishi, Tatsuro Misu, Kazuo Fujihara, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Toshiyuki Takahashi, Hiroshi Kuroda, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima, Atsushi Hozawa

Scientific reports　11　(1)　22357-22357　2021年11月16日

DOI： 10.1038/s41598-021-01942-8 　

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Multiple sclerosis (MS) is a major demyelinating disease of the central nervous system; however, its exact mechanism is unknown. This study aimed to elucidate the profile of white blood cells (WBCs) in the acute phase of an MS attack. Sixty-four patients with MS at the time of diagnosis and 2492 age- and sex-adjusted healthy controls (HCs) were enrolled. Data regarding the blood cell counts were compared between the groups. The total WBC (p < 0.0001), monocyte (p < 0.0001), basophil (p = 0.0027), and neutrophil (p < 0.0001) counts were higher in the MS group than in the HC group, whereas the lymphocyte and eosinophil counts did not differ. Adjustments for the smoking status and body mass index yielded the same results. The total and differential WBC counts of the patients with MS did not correlate with the counts of T2 hyperintense brain lesions or the levels of neurological disturbance. In summary, patients with MS showed elevated counts of total WBCs, monocytes, basophils, and neutrophils at the time of diagnosis. However, the clinical relevance of these biomarkers in the context of the development and progression of MS remains unclear.
Impact of type of reconstructed residence on social participation and mental health of population displaced by disasters. 国際誌

Tomomi Suzuki, Tetsuya Akaishi, Harumi Nemoto, Yusuke Utsumi, Moe Seto, Hitomi Usukura, Yasuto Kunii, Yumi Sugawara, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Atsushi Hozawa, Ichiro Tsuji, Tadashi Ishii, Hiroaki Tomita

Scientific reports　11　(1)　21465-21465　2021年11月2日

DOI： 10.1038/s41598-021-00913-3 　

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After disasters, people are often forced to reconstruct or move to new residences. This study aimed to reveal the association between the types of reconstructed residences and psychosocial or psychiatric conditions among the population. A total of 1071 adult residents in a coastal town, whose houses were destroyed by the tsunami caused by the Great East Japan Earthquake, enrolled in the study five years after the disaster. The type of reconstructed post-disaster residences (reconstructed on the same site/disaster-recovery public condominium/mass-translocation to higher ground/privately moving to remote areas) and the current psychosocial indicators were investigated. The results revealed that individuals living in public condominiums showed significantly worse scores on the Lubben Social Network Scale-6 (p < 0.0001) and the Center for Epidemiologic Studies Depression Scale (p < 0.0001), and slightly worse scores on the Kessler Psychological Distress Scale (p = 0.035) and the Impact of Event Scale-Revised (p = 0.028). Lower psychosocial indicator scores in the public condominium group were more remarkable in younger adults aged < 65 years. Insomnia evaluated using the Athens Insomnia Scale was not different among the four residential types. In summary, residents moving into disaster-recovery public condominiums are likely to have less social interaction, be more depressed, and may need additional interventions.
東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の概要

中谷直樹, 小暮真奈, 畑中里衣子, 菅野郁美, 中谷久美, 小原拓, 中村智洋, 宇留野晃, 布施昇男, 泉陽子, 丹野高三, 辻一郎, 栗山進一, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　80回　219-219　2021年11月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
統合失調症患者における日本語版WHODAS 2.0 12項目自己記入版の妥当性、信頼性の検討

和田里穂, 藤原雅樹, 山田裕士, 中谷直樹, 藤森麻衣子, 宋龍平, 児玉匡史, 樋口裕二, 掛田恭子, 内富庸介, 山田了士, 稲垣正俊

総合病院精神医学　33　(Suppl.)　S-165　2021年11月
出版者・発行元： (一社)日本総合病院精神医学会
ISSN：0915-5872
Association between the combined fat mass and fat-free mass index and hypertension: The Tohoku Medical Megabank Community-based Cohort Study. 国際誌

Masato Takase, Tomohiro Nakamura, Naho Tsuchiya, Mana Kogure, Fumi Itabashi, Akira Narita, Takumi Hirata, Naoki Nakaya, Yohei Hamanaka, Junichi Sugawara, Kichiya Suzuki, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

Clinical and experimental hypertension (New York, N.Y. : 1993)　43　(7)　610-621　2021年10月3日

DOI： 10.1080/10641963.2021.1925681 　

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BACKGROUND: A higher body fat percentage is associated with hypertension, even in non-obese individuals. The difference in body composition may be related to hypertension. The fat mass index (FMI) and fat-free mass index (FFMI) are proposed indicators of body composition. This study aimed to examine the relationship of a combination of FMI and FFMI with hypertension. METHODS: We conducted a cross-sectional study of 5,058 men and 11,842 women aged ≥ 20 years in the Miyagi Prefecture, northeastern Japan. The FMI and FFMI were calculated as the fat mass and fat-free mass divided by the height squared, respectively. The indices were classified into quartiles and combined into 16 groups. Hypertension was defined as casual blood pressure ≥ 140/90 mmHg and/or self-reported treatment for hypertension. Multivariable logistic regression models, adjusted for potential confounders, were used to assess the relationship of a combination of FMI and FFMI with hypertension. RESULTS: Higher FMI was associated with hypertension in most of the FFMI subgroups. Similarly, a higher FFMI was associated with hypertension in most of FMI subgroups. For men, the association between FFMI and hypertension in the lowest FMI group was not significant. CONCLUSIONS: Reducing the FMI and FFMI may be important in preventing hypertension. For men, the relationship between the FFMI and hypertension in the lowest FMI group might be weak.
Spousal similarities in cardiometabolic risk factors: A cross-sectional comparison between Dutch and Japanese data from two large biobank studies. 国際誌

Naoki Nakaya, Tian Xie, Bart Scheerder, Naho Tsuchiya, Akira Narita, Tomohiro Nakamura, Hirohito Metoki, Taku Obara, Mami Ishikuro, Atsushi Hozawa, Harold Snieder, Shinichi Kuriyama

Atherosclerosis　334　85-92　2021年10月

DOI： 10.1016/j.atherosclerosis.2021.08.037 　

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BACKGROUND AND AIMS: Few studies have examined and compared spousal concordance in different populations. This study aimed to quantify and compare spousal similarities in cardiometabolic risk factors and diseases between Dutch and Japanese populations. METHODS: This cross-sectional study included 28,265 Dutch Lifelines Cohort Study spouse pairs (2006-2013) and 5,391 Japanese Tohoku Medical Megabank Organization (ToMMo) Cohort Study pairs (2013-2016). Spousal similarities in cardiometabolic risk factors were evaluated using Pearson's correlation or logistic regression analyses adjusted for spousal age. RESULTS: The husbands' and wives' average ages in the Lifelines and ToMMo cohorts were 50.0 and 47.7 years and 63.2 and 60.4 years, respectively. Significant spousal similarities occurred with all cardiometabolic risk factors and diseases of interest in both cohorts. The age-adjusted correlation coefficients ranged from 0.032 to 0.263, with the strongest correlations observed in anthropometric traits. Spousal odds ratios [95% confidence interval] for the Lifelines vs. ToMMo cohort ranged from 1.45 (1.36-1.55) vs. 1.20 (1.05-1.38) for hypertension to 6.86 (6.30-7.48) vs. 4.60 (3.52-6.02) for current smoking. An increasing trend in spousal concordance with age was observed for sufficient physical activity in both cohorts. For current smoking, those aged 20-39 years showed the strongest concordance between pairs in both cohorts. The Dutch pairs showed stronger similarities in anthropometric traits and lifestyle habits (smoking and drinking) than their Japanese counterparts. CONCLUSIONS: Spouses showed similarities in several cardiometabolic risk factors among Dutch and Japanese populations, with regional and cultural influences on spousal similarities.
Encouraging participation in colorectal cancer screening for people with schizophrenia: A randomized controlled trial. 国際誌

Masaki Fujiwara, Yuto Yamada, Taichi Shimazu, Masafumi Kodama, Ryuhei So, Takanori Matsushita, Yusaku Yoshimura, Shigeo Horii, Maiko Fujimori, Hirokazu Takahashi, Naoki Nakaya, Kyoko Kakeda, Tempei Miyaji, Shiro Hinotsu, Keita Harada, Hiroyuki Okada, Yosuke Uchitomi, Norihito Yamada, Masatoshi Inagaki

Acta psychiatrica Scandinavica　144　(4)　318-328　2021年10月

DOI： 10.1111/acps.13348 　

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OBJECTIVE: We examined the efficacy of a case management approach to improve participation in colorectal cancer screening among people with schizophrenia. METHODS: This was a randomized, parallel group trial. We recruited outpatients with schizophrenia aged 40 years or over from two psychiatric hospitals in Japan. Participants were randomly assigned (1:1) to treatment as usual or case management intervention plus treatment as usual using a web-based system. Attending clinicians and participants were unmasked to the allocation. Case management included education and patient navigation for colorectal cancer screening using a fecal occult blood test. Treatment as usual included direct mail government recommendations. The primary endpoint was participation in colorectal cancer screening assessed using municipal records. We also assessed the secondary endpoint of participation in other cancer screenings (lung, gastric, breast, and cervical). RESULTS: Between June 3 and September 9, 2019, 172 eligible participants were randomly assigned to the case management plus treatment as usual group (n=86) or treatment as usual group (n=86). One participant was ineligible and another withdrew consent; both were excluded from analysis. A significantly higher proportion of participants received colorectal cancer screening in the case management plus treatment as usual group than in the treatment as usual group (40 [47.1%] of 85 participants vs. 10 [11.8%] of 85 participants, P<0.0001). The proportion of lung cancer screening also increased. No serious adverse events associated with the study intervention occurred. CONCLUSION: The case management intervention to encourage participation in colorectal cancer screening was effective for patients with schizophrenia.
Necroptosis in Esophageal Squamous Cell Carcinoma: An Independent Prognostic Factor and Its Correlation with Tumor-Infiltrating Lymphocytes. 国際誌

Takuro Yamauchi, Fumiyoshi Fujishima, Masatoshi Hashimoto, Junichi Tsunokake, Ryujiro Akaishi, Yusuke Gokon, Shunsuke Ueki, Yohei Ozawa, Toshiaki Fukutomi, Hiroshi Okamoto, Chiaki Sato, Yusuke Taniyama, Tomohiro Nakamura, Naoki Nakaya, Takashi Kamei, Hironobu Sasano

Cancers　13　(17)　2021年9月5日

DOI： 10.3390/cancers13174473 　

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Necroptosis is a pivotal process in cancer biology; however, the clinical significance of necroptosis in esophageal squamous cell carcinoma (ESCC) has remained unknown. Therefore, in this study, we aimed to verify the potential involvement of necroptosis in the clinical outcome, chemotherapeutic resistance, and tumor microenvironment of ESCC. Mixed lineage kinase domain-like protein (MLKL) and phosphorylated MLKL (pMLKL) were immunohistochemically examined in 88 surgically resected specimens following neoadjuvant chemotherapy (NAC) and 53 pre-therapeutic biopsy specimens, respectively. Tumor-infiltrating lymphocytes (TILs) were also evaluated by immunolocalizing CD3, CD8, and forkhead box protein 3 (FOXP3) in the residual tumors after NAC. High pMLKL status in the post-NAC resected specimens was significantly correlated with worse prognosis in ESCC patients. Multivariate analysis demonstrated that a high pMLKL status was an independent prognostic factor. In pre-NAC biopsy specimens, a high pMLKL status was significantly associated with a lower therapeutic efficacy. CD8+ TILs were significantly lower in the high-pMLKL group. FOXP3+ TILs were significantly higher in both high-MLKL and high-pMLKL groups. We first demonstrated pMLKL status as an independent prognostic factor in ESCC patients. Our study revealed the possible involvement of necroptosis in the immunosuppressive microenvironment, resulting in the attenuated therapeutic efficacy of NAC and eventual adverse clinical outcomes in ESCC.
A Cross-sectional Study of Attention Bias for Facial Expression Stimulation in Patients with Stroke at the Convalescence Stage. 国際誌

Hirokazu Takizawa, Toshiyuki Ishioka, Kohei Koizumi, Jun Tayama, Makoto Suzuki, Naoki Nakaya, Toyohiro Hamaguchi

International journal of behavioral medicine　28　(4)　511-522　2021年8月

DOI： 10.1007/s12529-020-09940-2 　

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BACKGROUND: Post-stroke depression increases the likelihood of adverse physical symptoms. Attentional bias (AB) for negative stimuli is important in depression onset, maintenance, and remission. Stroke is more likely in older adults, who can have reduced cognitive function. Individuals with mild cognitive impairment (MCI) can have delayed reaction times (RTs). We hypothesized that RT to select neutral facial expression is affected by depressive symptoms and cognitive function in patients with stroke. METHODS: This study analyzed 61 patients with stroke. Beck Depression Inventory-Second Edition (BDI-II) and Profile of Mood States (short version) scores were determined. Task stimuli comprised eight pairs of facial expressions containing affective (angry) and neutral faces. AB was measured as the RT to select the neutral face in two simultaneously presented images using attention bias modification (ABM) software. Patients were grouped according to depressive symptoms using BDI-II scores. Between-subject factors of depressive symptoms and cognitive function were determined by ANCOVA. RESULTS: No significant interaction was found between depressive symptoms and cognitive function on RT. There was a main effect of cognitive function, but not depressive symptoms. In patients with hemiparesis and depressive symptoms, RT was significantly shorter in patients without MCI compared with patients with MCI. CONCLUSIONS: People with stroke and elevated depression symptoms with hemiparesis but without MCI quickly selected neutral facial expressions from neutral and aversive expressions, and thus do not need ABM to escape aversive stimuli. ABM in response to aversive stimuli may be useful in evaluating negative emotions in individuals with post-stroke depression without MCI.
Prevention of delayed bleeding with vonoprazan in upper gastrointestinal endoscopic treatment.

Hiroko Abe, Waku Hatta, Yohei Ogata, Tomoyuki Koike, Masahiro Saito, Xiaoyi Jin, Kenichiro Nakagawa, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Tomohiro Nakamura, Naoki Nakaya, Kunio Tarasawa, Kenji Fujimori, Kiyohide Fushimi, Atsushi Masamune

Journal of gastroenterology　56　(7)　640-650　2021年7月

DOI： 10.1007/s00535-021-01781-4 　

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BACKGROUND: Delayed bleeding is the major adverse event in upper gastrointestinal endoscopic treatment (UGET). We aimed to investigate the efficacy of vonoprazan, which is the novel strong antisecretory agent, to reduce the risk for delayed bleeding in comparison with proton pump inhibitors (PPIs) in UGET. METHODS: This retrospective population-based cohort study used the Diagnosis Procedure Combination database in Japan. We included patients on vonoprazan or PPI in UGET between 2014 and 2019. The primary outcome was delayed bleeding. We conducted propensity score matching to balance the comparison groups, and logistic regression analyses to compare the bleeding outcomes. RESULTS: We enrolled 124,422 patients, in which 34,822 and 89,600 were prescribed with vonoprazan and PPI, respectively. After propensity score matching, the risk for delayed bleeding was lower in vonoprazan than in PPI (odds ratio [OR], 0.75; 95% confidence interval [CI], 0.71-0.80), consistent with sensitivity analysis results. In the subgroup analyses of seven UGET procedures, vonoprazan was significantly advantageous in esophageal endoscopic submucosal dissection (E-ESD) (OR, 0.71; 95% CI, 0.54-0.94) and gastroduodenal endoscopic submucosal dissection (GD-ESD) (OR, 0.70; 95% CI, 0.65-0.75), although correction for multiple testing of the outcome data removed the significance in E-ESD. These results were also consistent with sensitivity analysis results. In the five other procedures, no significant advantage was found. CONCLUSIONS: This nationwide study found that, compared with PPI, vonoprazan can reduce delayed bleeding with approximately 30% in GD-ESD. Vonoprazan has the possibility to become a new treatment method for preventing delayed bleeding in this procedure.
Risk of metastatic recurrence after endoscopic resection for esophageal squamous cell carcinoma invading into the muscularis mucosa or submucosa: a multicenter retrospective study.

Waku Hatta, Tomoyuki Koike, So Takahashi, Tomohiro Shimada, Takuto Hikichi, Yosuke Toya, Ippei Tanaka, Yusuke Onozato, Koichi Hamada, Daisuke Fukushi, Ko Watanabe, Shoichi Kayaba, Hirotaka Ito, Tatsuya Mikami, Tomoyuki Oikawa, Yasushi Takahashi, Yutaka Kondo, Tetsuro Yoshimura, Takeharu Shiroki, Ko Nagino, Norihiro Hanabata, Akira Funakubo, Dai Hirasawa, Tetsuya Ohira, Jun Nakamura, Takayuki Matsumoto, Tomohiro Nakamura, Naoki Nakaya, Katsunori Iijima, Shinsaku Fukuda, Atsushi Masamune

Journal of gastroenterology　56　(7)　620-632　2021年7月

DOI： 10.1007/s00535-021-01787-y 　

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BACKGROUND: We aimed to elucidate the risk of metastatic recurrence after endoscopic resection (ER) without additional treatment for esophageal squamous cell carcinomas (ESCCs) with tumor invasion into the muscularis mucosa (pT1a-MM) or submucosa (T1b-SM). METHODS: We retrospectively enrolled patients with pT1a-MM/pT1b-SM ESCC after ER at 21 institutions in Japan between 2006 and 2017. We compared metastatic recurrence between patients with and without additional treatment, stratified into category A (pT1a-MM with negative lymphovascular invasion [LVI] and vertical margin [VM]), B (tumor invasion into the submucosa ≤ 200 µm [pT1b-SM1] with negative LVI and VM), and C (others). Subsequently, using multivariate Cox analysis, we evaluated risk factors for metastatic recurrence after ER without additional treatment. RESULTS: We enrolled 593 patients, and metastatic recurrence occurred in 38 patients. Metastatic recurrence after additional treatment was significantly lower than that after no additional treatment in category C (9.1% vs. 23.6% in 5 years, p = 0.001), whereas no significant difference was noted in categories A (0.0% vs. 2.6%) and B (0.0% vs. 4.3%). In patients without additional treatment after ER, risk factors for metastatic recurrence were lymphatic invasion (hazard ratio [HR], 5.61), positive VM (HR, 4.55), and tumor invasion into the submucosa > 200 μm (HR, 3.25), and, but near half of the patients with metastatic recurrence had no further recurrence after salvage treatment, resulting in excellent 5-year disease-specific survival in categories A (99.6%) and B (100.0%). CONCLUSIONS: Closed follow-up with no additional treatment may be an acceptable option after ER in pT1a-MM/pT1b-SM1 ESCC with negative LVI and VM.
Impacts of the urinary sodium-to-potassium ratio, sleep efficiency, and conventional risk factors on home hypertension in a general Japanese population. 国際誌

Takumi Hirata, Mana Kogure, Naho Tsuchiya, Ken Miyagawa, Akira Narita, Kotaro Nochioka, Akira Uruno, Taku Obara, Tomohiro Nakamura, Naoki Nakaya, Hirohito Metoki, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　44　(7)　858-865　2021年7月

DOI： 10.1038/s41440-021-00628-y 　

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Recently, a high urinary sodium-to-potassium (Na/K) ratio and reduced sleep efficiency, in addition to conventional risk factors (obesity and excess alcohol intake), have been identified as risk factors for hypertension. We estimated the population attributable fraction (PAF) for home hypertension due to these risk factors in a general Japanese population. We conducted a cross-sectional study including 1384 participants (393 men and 991 women) to estimate the odds ratio (OR) and 95% confidence interval (CI) for the presence of any of the conventional risk factors using multivariable logistic regression analyses. The models were adjusted for sex, age, smoking status, and log-transformed average daily steps. We also estimated the OR and 95% CI for the presence of any of the overall risk factors. Furthermore, we calculated the PAF due to these risk factors. The results showed that the prevalence of home hypertension was 39.0% (540/1384). The presence of any of the conventional risk factors, as well as any of the overall risk factors, was significantly associated with an increased prevalence of hypertension (OR 2.80, 95% CI 2.15-3.65; OR 2.50, 95% CI 1.93-3.22, respectively). The PAF for hypertension due to the presence of any of the conventional risk factors and the PAF due to the presence of any of the overall risk factors were 30.2% and 39.0%, respectively. In conclusion, the impact of the overall risk factors, including the urinary Na/K ratio and sleep efficiency, on home hypertension was higher than that of conventional risk factors alone. The management of the urinary Na/K ratio and sleep efficiency as well as conventional risk factors might be important in the management of blood pressure.
Five-year Psychosocial Impact of Living in Post-Disaster Prefabricated Temporary Housing. 国際誌

Tetsuya Akaishi, Tomomi Suzuki, Harumi Nemoto, Yusuke Utsumi, Moe Seto, Hitomi Usukura, Yasuto Kunii, Yumi Sugawara, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Atsushi Hozawa, Ichiro Tsuji, Tadashi Ishii, Hiroaki Tomita

Disaster medicine and public health preparedness　1-31　2021年6月23日

DOI： 10.1017/dmp.2021.212 　

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OBJECTIVE: This study aims to evaluate the long-term impact of living in post-disaster prefabricated temporary housing on social interaction activities and mental health status. METHODS: A total of 917 adult residents in a coastal town, whose residences were destroyed by the tsunami caused by the Great East Japan Earthquake (GEJE), were enrolled for the assessment held five years after the disaster. They answered questions about their experience and consequence of living in prefabricated temporary housing after the disaster. Their present scores on five types of self-reported measures regarding the psychosocial or psychiatric status and their present and recalled social interaction activities were cross-sectionally collected. RESULTS: A total of 587 (64.0%) participants had a history of living in prefabricated temporary housing, while the other 330 (36.0%) had not. The prevalence of social interaction activities significantly decreased after the GEJE. However, the experience of living in prefabricated temporary housing did not adversely affect the subsequent social interaction activities or mental conditions of the participants five years after the disaster. CONCLUSIONS: Living in post-disaster prefabricated temporary housing may not negatively impact subsequent psychosocial conditions or social interaction activities five years later.
miRNA Changes in Retinal Ganglion Cells after Optic Nerve Crush and Glaucomatous Damage. 国際誌

Ben Mead, Alicia Kerr, Naoki Nakaya, Stanislav I Tomarev

Cells　10　(7)　2021年6月22日

DOI： 10.3390/cells10071564 　

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The purpose of this study was to characterize the miRNA profile of purified retinal ganglion cells (RGC) from healthy and diseased rat retina. Diseased retina includes those after a traumatic optic nerve crush (ONC), and after ocular hypertension/glaucoma. Rats were separated into four groups: healthy/intact, 7 days after laser-induced ocular hypertension, 2 days after traumatic ONC, and 7 days after ONC. RGC were purified from rat retina using microbeads conjugated to CD90.1/Thy1. RNA were sequenced using Next Generation Sequencing. Over 100 miRNA were identified that were significantly different in diseased retina compared to healthy retina. Considerable differences were seen in the miRNA expression of RGC 7 days after ONC, whereas after 2 days, few changes were seen. The miRNA profiles of RGC 7 days after ONC and 7 days after ocular hypertension were similar, but discrete miRNA differences were still seen. Candidate mRNA showing different levels of expression after retinal injury were manipulated in RGC cultures using mimics/AntagomiRs. Of the five candidate miRNA identified and subsequently tested for therapeutic efficacy, miR-194 inhibitor and miR-664-2 inhibitor elicited significant RGC neuroprotection, whereas miR-181a mimic and miR-181d-5p mimic elicited significant RGC neuritogenesis.
Does a combination treatment of repetitive transcranial magnetic stimulation and occupational therapy improve upper limb muscle paralysis equally in patients with chronic stroke caused by cerebral hemorrhage and infarction?: A retrospective cohort study. 国際誌

Hisashi Tatsuno, Toyohiro Hamaguchi, Jinichi Sasanuma, Kiyohito Kakita, Takatsugu Okamoto, Masato Shimizu, Naoki Nakaya, Masahiro Abo

Medicine　100　(24)　e26339　2021年6月18日

DOI： 10.1097/MD.0000000000026339 　

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ABSTRACT: The clinical presentation of stroke is usually more severe in patients with intracerebral hemorrhage (ICH) than in those with cerebral infarction (CI); recovery of stroke-related muscle paralysis is influenced and limited by the type of stroke. To date, many patients have been treated by neurorehabilitation; however, the changes in the recovery of motor paralysis depending on the type of stroke, ICH or CI, have not been established. This study aimed to determine this difference in improvement of upper extremity paralysis using 2-week in-hospital NovEl intervention Using Repetitive transcranial magnetic stimulation combined with Occupational therapy (NEURO).We scrutinized the medical records of all patients with poststroke (ICH or CI) upper extremity muscle paralysis using Fugl-Meyer assessments (FMAs) who had been admitted to 6 hospitals between March 2010 and December 2018 for rehabilitation treatment. This was a multiinstitutional, open-label, retrospective cohort study without control patients. We evaluated the effects of NEURO on patients with CI and ICH by dividing them into 2 groups according to the type of stroke, after adjustment for age, sex, dominant hand, affected hand side, time since stroke, and prediction of recovery capacity in the upper extremity.The study included 1716 (CI [n = 876] and ICH [n = 840]) patients who had undergone at least 2 FMAs and had experienced stroke at least 6 months before. The type of stroke had no effect on the outcomes (changes in the FMA-upper extremity score, F[4,14.0] = 2.05, P = .09, partial η2 = 0.01). Patients from all 5 groups equally benefited from the treatment (improvement in FMA scores) according to the sensitivity analysis-stratified analysis (F = 0.08 to 1.94, P > .16, partial η2 < 0.001).We conclude that NEURO can be recommended for chronic stroke patients irrespective of the type of stroke.
Correction to: a Cross-sectional Study of Attention Bias for Facial Expression Stimulation in Patients with Stroke at the Convalescence Stage. 国際誌

Hirokazu Takizawa, Toshiyuki Ishioka, Kohei Koizumi, Jun Tayama, Makoto Suzuki, Naoki Nakaya, Toyohiro Hamaguchi

International journal of behavioral medicine　28　(3)　401-401　2021年6月

DOI： 10.1007/s12529-020-09948-8 　
Validity and Reliability of the Japanese Version of the 12-item Self-administered World Health Organization Disability Assessment Schedule (WHODAS) 2.0 in Patients with Schizophrenia.

Riho Wada, Masaki Fujiwara, Yuto Yamada, Naoki Nakaya, Maiko Fujimori, Ryuhei So, Masafumi Kodama, Yuji Higuchi, Kyoko Kakeda, Yosuke Uchitomi, Norihito Yamada, Masatoshi Inagaki

Acta medica Okayama　75　(3)　315-322　2021年6月

DOI： 10.18926/AMO/62226 　

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It is necessary to assess functional impairment when treating schizophrenia. The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) has been adopted as a measure of functional disability in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. This study was a secondary analysis from a cross-sectional study of health-related behaviors among patients with schizophrenia. We examined the validity and reliability of the Japanese version of the 12-item WHODAS 2.0 when self-administered by such patients. Participants were 350 outpatients with schizophrenia from a psychiatric hospital. The standard six-factor structure of the WHODAS 2.0 showed a good fit for these participants. The Cronbach's alpha coefficient was 0.858, showing good internal consistency. The WHODAS 2.0 showed moderate correlations with the modified Global Assessment of Functioning and Kessler 6 scales (r=-0.434 and 0.555, respectively). The results of this study show that the Japanese version of the 12-item self-administered WHODAS 2.0 has good internal consistency and convergent validity among patients with schizophrenia. Further exploration of the usefulness of WHODAS 2.0 in clinical settings is needed.
Association between the social isolation and depressive symptoms after the great East Japan earthquake: findings from the baseline survey of the TMM CommCohort study. 国際誌

Yuka Kotozaki, Kozo Tanno, Kiyomi Sakata, Eri Takusari, Kotaro Otsuka, Hiroaki Tomita, Ryohei Sasaki, Nobuyuki Takanashi, Takahiro Mikami, Atsushi Hozawa, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Yasuyuki Taki, Atsushi Shimizu, Jiro Hitomi, Mamoru Satoh, Makoto Sasaki

BMC public health　21　(1)　925-925　2021年5月15日

DOI： 10.1186/s12889-021-10896-5 　

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BACKGROUND: Social isolation and mental health issues have become a severe problem in disaster areas in the Great East Japan Earthquake. This study examined whether the combination of the house damage and social isolation or the combination of the death of family members and social isolation is associated with depressive symptoms among survivors using the baseline study data of the Tohoku Medical Megabank Project Community-Based Cohort Study (TMM CommCohort Study). METHODS: We used cross-sectional data from a baseline survey of 48,958 participants (18,423 males, 30,535 females; aged 60.1 ± 11.2 years) to examine the association between social isolation measured by the Lubben social network scale 6 (LSNS-6) and depressive symptoms measured by the Center for Epidemiological Studies-Depressive Scale (CES-D). The presence of social isolation and depressive symptoms was defined by an LSNS-6 score of < 12 and a CES-D score of ≥16, respectively. We performed a logistic regression analysis to determine the multivariable-adjusted odds ratio (95% confidence interval) [AOR (95% CI)] for depressive symptoms according to sex in the social isolation in comparison to without social isolation, and the associations of the combination of the house damage or the death of family members and social isolation and depressive symptoms. RESULTS: Social isolation was significantly associated with depressive symptoms (males: OR = 1.87; 95% CI = 1.72-2.04, females: OR = 2.13; 95% CI = 2.00-2.26). Both males and females respondents with severe house damage and social isolation had a greater risk of depressive symptoms in comparison to those with an undamaged house and without social isolation (males: OR = 3.40; 95% CI = 2.73-4.24, females: OR = 2.92; 95% CI = 2.46-3.46). The risk of depressive symptoms was also higher in both males and females respondents with the death of family members and social isolation in comparison to those without the death of family members and without social isolation (males: OR = 2.18; 95% CI = 1.90-2.50, females: OR = 2.60; 95% CI = 2.35-2.88). CONCLUSION: The findings suggested that a combination of social isolation and severe house damage and the death of family members caused by a large-scale natural disaster was associated with a higher risk of depressive symptoms although the interaction was not statistically significant.
[Role of Palliative Care in the Introduction of Chemotherapy in Patients with Poor Performance Status].

Itaru Sato, Naoki Nakaya, Yoko Obara, Natsumi Kurosaka, Souichirou Ueno, Hideo Nakajima

Gan to kagaku ryoho. Cancer & chemotherapy　48　(5)　735-737　2021年5月

ISSN：0385-0684

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Chemotherapy for patients with poor performance status(PS)is not recommended because it increases the risk of death and shortens their survival. We report on 3 cases in which palliative care improved PS and enabled chemotherapy, resulting in a prolonged prognosis. Case 1 involves a 57‒year‒old woman with multiple lung, liver, and bone metastases from breast cancer who was administered celecoxib and oxycodone. She received Mohs paste therapy. Her PS improved from 3 to 2, and paclitaxel and trastuzumab were started; however, the patient died on day 861. Case 2 involves a 53‒year‒old woman with multiple lymph node metastases from carcinoma of an unknown primary cause. She was administered oxycodone, loxoprofen, and dexamethasone. Her PS improved from 4 to 3. The biopsy of her bone marrow showed diffuse large B‒cell lymphoma. The patient is still alive, 6 years and 10 months after the introduction of R‒CHOP. In case 3, a 57‒year‒old man with multiple bone metastases from small cell lung cancer was administered loxoprofen and betamethasone. His PS improved from 4 to 3. Etoposide and carboplatin were administered to him, but the patient died on day 692. Palliative care may enable the introduction of chemotherapy and consequently improve prognosis.
Efficacy of attention bias modification combined with cognitive behavioral therapy for reducing anxiety in patients with hematopoietic malignancies: a quasi-randomized controlled trial

Koizumi Kohei, Hamaguchi Toyohiro, Tayama Jun, Ishioka Toshiyuki, Nakamura-Thomas Hiromi, Koike Yuji, Nakaya Naoki, Konno Michiko, Makita Shigeru

Journal of Affective Disorders Reports　4　100122-100122　2021年4月
出版者・発行元： Elsevier BV
DOI： 10.1016/j.jadr.2021.100122 　

ISSN：2666-9153
機能性消化管疾患群における便通異常ならびに消化管通過に対するkiwifruitとpsylliumの比較検証試験

大川洋平, 中谷久美, 村椿智彦, 岡本智子, 布田美貴子, 遠藤由香, 鹿野理子, 金澤素, 中谷直樹, Barbara Giovanni, Gearry Richard, Ansell Juliet, Kuhn-Sherlock Barbara, Drummond Lynley, 福土審

心身医学　61　(2)　197-198　2021年3月
出版者・発行元： (一社)日本心身医学会
ISSN：0385-0307
Prediction model of bleeding after endoscopic submucosal dissection for early gastric cancer: BEST-J score. 国際誌査読有り

Waku Hatta, Yosuke Tsuji, Toshiyuki Yoshio, Naomi Kakushima, Shu Hoteya, Hisashi Doyama, Yasuaki Nagami, Takuto Hikichi, Masakuni Kobayashi, Yoshinori Morita, Tetsuya Sumiyoshi, Mikitaka Iguchi, Hideomi Tomida, Takuya Inoue, Tomoyuki Koike, Tatsuya Mikami, Kenkei Hasatani, Jun Nishikawa, Tomoaki Matsumura, Hiroko Nebiki, Dai Nakamatsu, Ken Ohnita, Haruhisa Suzuki, Hiroya Ueyama, Yoshito Hayashi, Mitsushige Sugimoto, Shinjiro Yamaguchi, Tomoki Michida, Tomoyuki Yada, Yoshiro Asahina, Toshiaki Narasaka, Shiko Kuribasyashi, Shu Kiyotoki, Katsuhiro Mabe, Tomohiro Nakamura, Naoki Nakaya, Mitsuhiro Fujishiro, Atsushi Masamune

Gut　70　(3)　476-484　2021年3月

DOI： 10.1136/gutjnl-2019-319926 　

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OBJECTIVE: Bleeding after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) is a frequent adverse event after ESD. We aimed to develop and externally validate a clinically useful prediction model (BEST-J score: Bleeding after ESD Trend from Japan) for bleeding after ESD for EGC. DESIGN: This retrospective study enrolled patients who underwent ESD for EGC. Patients in the derivation cohort (n=8291) were recruited from 25 institutions, and patients in the external validation cohort (n=2029) were recruited from eight institutions in other areas. In the derivation cohort, weighted points were assigned to predictors of bleeding determined in the multivariate logistic regression analysis and a prediction model was established. External validation of the model was conducted to analyse discrimination and calibration. RESULTS: A prediction model comprised 10 variables (warfarin, direct oral anticoagulant, chronic kidney disease with haemodialysis, P2Y12 receptor antagonist, aspirin, cilostazol, tumour size >30 mm, lower-third in tumour location, presence of multiple tumours and interruption of each kind of antithrombotic agents). The rates of bleeding after ESD at low-risk (0 to 1 points), intermediate-risk (2 points), high-risk (3 to 4 points) and very high-risk (≥5 points) were 2.8%, 6.1%, 11.4% and 29.7%, respectively. In the external validation cohort, the model showed moderately good discrimination, with a c-statistic of 0.70 (95% CI, 0.64 to 0.76), and good calibration (calibration-in-the-large, 0.05; calibration slope, 1.01). CONCLUSIONS: In this nationwide multicentre study, we derived and externally validated a prediction model for bleeding after ESD. This model may be a good clinical decision-making support tool for ESD in patients with EGC.
Relationship Between Calcium Intake and Impaired Activities of Daily Living in a Japanese Population: NIPPON DATA90. 査読有り

Mana Kogure, Naho Tsuchiya, Akira Narita, Takumi Hirata, Naoki Nakaya, Tomohiro Nakamura, Atsushi Hozawa, Takehito Hayakawa, Nagako Okuda, Naoko Miyagawa, Aya Kadota, Takayoshi Ohkubo, Yoshitaka Murakami, Kiyomi Sakata, Katsuyuki Miura, Akira Okayama, Tomonori Okamura, Hirotsugu Ueshima

Journal of epidemiology　31　(2)　119-124　2021年2月5日

DOI： 10.2188/jea.JE20190234 　

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BACKGROUND: Major reasons for long-term care insurance certification in Japan are stroke, dementia and fracture. These diseases are reported to be associated with calcium intake. This study examined the association between calcium intake and impaired activities of daily living (ADL) using the data from NIPPON DATA90, consisting of representative sample of the Japanese population. METHODS: A population-based nested case control study was performed. A baseline survey was conducted in 1990, followed by ADL surveys of individuals ≥65 years old in 2000. Individuals with impaired ADL and selected age- and sex-matched controls were then identified. We obtained 132 pairs. Calcium intake was energy-adjusted using the residual method. The association between calcium intake and impaired ADL was examined using conditional logistic regression models. To assess the accuracy of the estimates, we conducted bootstrap analyses. RESULTS: The adjusted odds ratios (ORs) for impaired ADL compared with the group with a calcium intake of <476 mg/day were 0.72 (95% confidence interval, 95% CI: 0.37-1.40) for the 476-606 mg/day group and 0.44 (0.21-0.94) for the ≥607 mg/day group in 2000 (P for linear trend = 0.03). After the bootstrap analyses, the inverse relationship unchanged (median OR per 100-mg rise in calcium intake: 0.87 [1,000 resamplings], 95% CI: 0.76-0.97). CONCLUSIONS: After bootstrap analyses, calcium intake was inversely associated with impaired ADL, 10 years after the baseline survey.
Coffee consumption and mortality in Japan with 18 years of follow-up: the Jichi Medical School Cohort Study 査読有り

T. Sakamaki, K. Kayaba, K. Kotani, M. Namekawa, T. Hamaguchi, N. Nakaya, S. Ishikawa

Public Health　191　23-30　2021年2月
出版者・発行元：
DOI： 10.1016/j.puhe.2020.10.021 　

ISSN：0033-3506

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Objective: Coffee consumption can be expected to reduce mortality due to cardiovascular diseases and cancer. This study tested the hypothesis of an inverse association between coffee intake and all-cause mortality and mortality due to cancer, coronary heart disease, or stroke. Study design: Prospective cohort study. Methods: We analyzed data from the Jichi Medical School Cohort Study, Japan, enrolling 9946 subjects (men/women: 3870/6,076, age: 19e93 years) from 12 communities. A food frequency questionnaire assessing the subjects’ daily coffee consumption was used. Results: During an average follow-up of 18.4 years, the total number of deaths was 2024, including 677 for cancer, 238 for coronary heart disease, and 244 for stroke. Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) of all-cause mortality and cause specific mortality due to cancer, coronary heart disease, and stroke. Overall, no significant association was shown between coffee consumption and all-cause mortality. In the cause-specific mortality analyses, stroke mortality was significantly lower in those who consumed 1e2 cups of coffee daily (HR [95% CI]: 0.63 [0.42e0.95]) than in those who do not consume coffee, and this association occurred only in men. Conclusion: This study showed no significant association between coffee consumption and all-cause mortality. A U-shaped association between coffee consumption and stroke mortality with a 37% lower stroke mortality, only significant in men who consume 1e2 cups of coffee daily was observed. It is necessary to examine the possibility of intervention studies to reduce stroke mortality through coffee consumption.
Correction: Sodium/potassium ratio change was associated with blood pressure change: possibility of population approach for sodium/potassium ratio reduction in health checkup. 国際誌

Mana Kogure, Naoki Nakaya, Takumi Hirata, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Yoko Suto, Yoko Honma, Hidemi Sasaki, Ken Miyagawa, Yusuke Ushida, Hiroyuki Ueda, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　44　(2)　262-262　2021年2月

DOI： 10.1038/s41440-020-00547-4 　

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An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Sodium/potassium ratio change was associated with blood pressure change: possibility of population approach for sodium/potassium ratio reduction in health checkup. 国際誌査読有り

Mana Kogure, Naoki Nakaya, Takumi Hirata, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Yoko Suto, Yoko Honma, Hidemi Sasaki, Ken Miyagawa, Yusuke Ushida, Hiroyuki Ueda, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　44　(2)　225-231　2021年2月

DOI： 10.1038/s41440-020-00536-7 　

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Recently, the sodium (Na)/potassium (K) ratio was reported to be associated with blood pressure (BP). A Na/K ratio self-monitoring device using spot urine was established recently. Here, we assessed whether the urinary Na/K ratio change measured using the Na/K device was associated with BP change in a health checkup setting. We targeted 12,890 participants who attended the health checkup in Tome City, Miyagi between 2017 and 2018. Tome City introduced urinary Na/K ratio measurements during health checkups since 2017. For each year, we compared the baseline characteristics according to the urinary Na/K ratio and BP level. We assessed the relationship between change in urinary Na/K ratio and BP change using multiple regression analyses adjusted for age, sex, and change in body mass index (BMI) and alcohol intake. The average urinary Na/K ratio was significantly lower in 2018 than in 2017 (5.4 ± 3.0 to 4.9 ± 2.2, P < 0.01). The systolic BP of the participants in 2018 (130.9 ± 17.4 mmHg) was lower than that in 2017 (132.1 ± 17.9 mmHg). Moreover, the change in systolic BP and diastolic BP was positively associated with the change in urinary Na/K ratio. In conclusion, the association of the change in urinary Na/K ratio with hypertension and changes in systolic and diastolic BP can be explained by a change in alcohol intake, BMI, and urinary Na/K ratio. Therefore, measuring the urinary Na/K ratio in community settings is a potential population approach for counteracting hypertension.
Study Profile of the Tohoku Medical Megabank Community-Based Cohort Study. 査読有り

Atsushi Hozawa, Kozo Tanno, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Akira Narita, Mana Kogure, Kotaro Nochioka, Ryohei Sasaki, Nobuyuki Takanashi, Kotaro Otsuka, Kiyomi Sakata, Shinichi Kuriyama, Masahiro Kikuya, Osamu Tanabe, Junichi Sugawara, Kichiya Suzuki, Yoichi Suzuki, Eiichi N Kodama, Nobuo Fuse, Hideyasu Kiyomoto, Hiroaki Tomita, Akira Uruno, Yohei Hamanaka, Hirohito Metoki, Mami Ishikuro, Taku Obara, Tomoko Kobayashi, Kazuyuki Kitatani, Takako Takai-Igarashi, Soichi Ogishima, Mamoru Satoh, Hideki Ohmomo, Akito Tsuboi, Shinichi Egawa, Tadashi Ishii, Kiyoshi Ito, Sadayoshi Ito, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Masao Nagasaki, Kazuhiko Igarashi, Seizo Koshiba, Ritsuko Shimizu, Gen Tamiya, Keiko Nakayama, Hozumi Motohashi, Jun Yasuda, Atsushi Shimizu, Tsuyoshi Hachiya, Yuh Shiwa, Teiji Tominaga, Hiroshi Tanaka, Kotaro Oyama, Ryoichi Tanaka, Hiroshi Kawame, Akimune Fukushima, Yasushi Ishigaki, Tomoharu Tokutomi, Noriko Osumi, Tadao Kobayashi, Fuji Nagami, Hiroaki Hashizume, Tomohiko Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Ryujin Endo, Satoshi Nishizuka, Ichiro Tsuji, Jiro Hitomi, Motoyuki Nakamura, Kuniaki Ogasawara, Nobuo Yaegashi, Kengo Kinoshita, Shigeo Kure, Akio Sakai, Seiichiro Kobayashi, Kenji Sobue, Makoto Sasaki, Masayuki Yamamoto

Journal of epidemiology　31　(1)　65-76　2021年1月5日

DOI： 10.2188/jea.JE20190271 　

ISSN：0917-5040

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BackgroundWe established a community-based cohort study to assess the long-term impact of the Great East Japan Earthquake on disaster victims and gene-environmental interactions on the incidence of major diseases such as cancer and cardiovascular diseases.MethodsWe asked participants to join our cohort in the health check-up settings and assessment center based settings. Inclusion criteria was aged 20 years or over and living in Miyagi or Iwate Prefecture. We obtained information on lifestyle, effect of disaster, blood, and urine information (Type 1 survey), and some detailed measurements (Type 2 survey), for example, carotid echography, calcaneal ultrasound bone mineral density, and so on. All participants agreed to measure genome information and to distribute their information widely.ResultsAs a result, 87,865 gave their informed consent to join our study. Participation rate at health check-up site was about 70%. The participants with Type 1 survey were more likely to have psychological distress than those of Type 2 survey, and women were more likely to have psychological distress than men. Additionally, coastal residents were more likely to have higher degrees of psychological distress than inland residents regardless of sex.ConclusionThis cohort comprised large sample size and it contains information on disaster, genome information, and metabolome information. This cohort also had several detailed measurements. Using this cohort enabled us to clarify the long-term effect of disaster and also to establish personalized prevention based on genome, metabolome, and other omics information.
回復期脳卒中患者の表情刺激に対する注意バイアスには心理状態と認知機能が影響する

滝澤宏和, 小泉浩平, 田山淳, 中谷直樹, 濱口豊太

行動医学研究　26　(Suppl.)　48-48　2021年
出版者・発行元：日本行動医学会
ISSN：1341-6790

eISSN：2188-0085
東日本大震災被災高齢者における心理的苦痛と要介護発生リスクとの関連生活習慣と疼痛の媒介効果

曽根稔雅, 菅原由美, 丹治史也, 中谷直樹, 辻一郎

Journal of Epidemiology　31　(Suppl.)　93-93　2021年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
脂肪量指数および除脂肪量指数の組み合わせとHbA1cとの関連

高瀬雅仁, 中村智洋, 平田匠, 小暮真奈, 板橋芙美, 土屋菜歩, 中谷直樹, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

Journal of Epidemiology　31　(Suppl.)　101-101　2021年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
東北メディカル・メガバンク計画地域住民コホート特定健診共同参加型対象者の基礎特性とがん罹患の関連

寳澤篤, 小原拓, 中村智洋, 板橋芙美, 小暮真奈, 成田暁, 土屋菜歩, 平田匠, 中谷直樹, 菅原準一, 栗山進一, 布施昇男, 辻一郎, 呉繁夫

Journal of Epidemiology　31　(Suppl.)　116-116　2021年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
住環境の主観的評価と心理的苦痛との関連

菅野郁美, 長谷川兼一, 中村智洋, 土屋菜歩, 小暮真奈, 板橋芙美, 成田暁, 平田匠, 中谷直樹, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

Journal of Epidemiology　31　(Suppl.)　143-143　2021年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
脂肪量指数および除脂肪量指数の組み合わせとHbA1cとの関連

高瀬雅仁, 中村智洋, 平田匠, 小暮真奈, 板橋芙美, 土屋菜歩, 中谷直樹, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

Journal of Epidemiology　31　(Suppl.)　101-101　2021年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
東北メディカル・メガバンク計画地域住民コホート特定健診共同参加型対象者の基礎特性とがん罹患の関連

寳澤篤, 小原拓, 中村智洋, 板橋芙美, 小暮真奈, 成田暁, 土屋菜歩, 平田匠, 中谷直樹, 菅原準一, 栗山進一, 布施昇男, 辻一郎, 呉繁夫

Journal of Epidemiology　31　(Suppl.)　116-116　2021年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
住環境の主観的評価と心理的苦痛との関連

菅野郁美, 長谷川兼一, 中村智洋, 土屋菜歩, 小暮真奈, 板橋芙美, 成田暁, 平田匠, 中谷直樹, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

Journal of Epidemiology　31　(Suppl.)　143-143　2021年1月
出版者・発行元： (一社)日本疫学会
ISSN：0917-5040

eISSN：1349-9092
Effect of internet-based attention bias modification on the anxiety of Japanese workers: A randomized controlled trial. 国際誌

Jun Tayama, Akihito Shimazu, Sayaka Ogawa, Naoki Nakaya

Journal of occupational health　63　(1)　e12229　2021年1月

DOI： 10.1002/1348-9585.12229 　

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OBJECTIVES: This study comprised a randomized controlled trial to examine the effect of internet-based attention bias modification (iABM) on reducing workers' anxiety. METHODS: In total, 300 eligible participants were randomized according to sex and age; 180 were assigned to the intervention group and 120 to the control group. The word stimuli used in the iABM included eight positive words and eight neutral words. Participants were instructed to indicate the positive word's position as quickly and accurately as possible by tapping one of the two directions on display. The intervention included five sessions per participant over 1 month, resulting in a total of 600 trials. The main outcome measure was the total state anxiety score of the State-Trait Anxiety Inventory (STAI). RESULTS: There was no significant difference in the net change in STAI scores between the intervention and control groups. The mean reaction time of the fifth session was significantly shorter than the mean reaction time of the first session. Furthermore, although there was no effect on the index of effect size Δ, the paired t-test showed a significant decrease in the anxiety score. CONCLUSIONS: The iABM intervention in this study did not enhance the amelioration of workers' anxiety when compared with the control condition.
Predictors of Early and Late Mortality after Endoscopic Resection for Esophageal Squamous Cell Carcinoma.

Yohei Ogata, Waku Hatta, Tomoyuki Koike, Masahiro Saito, Xiaoyi Jin, Kenichiro Nakagawa, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Tomohiro Nakamura, Naoki Nakaya, Atsushi Masamune

The Tohoku journal of experimental medicine　253　(1)　29-39　2021年1月

DOI： 10.1620/tjem.253.29 　

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In esophageal squamous cell carcinoma (ESCC) comprising 90% of cases with esophageal cancer, endoscopic resection (ER) is recommended for patients with negligible risk of ESCC-related mortality. In fact, a main cause of death in patients underwent ER is not ESCC. We thus aimed to clarify the predictors for early and late mortality among patients underwent ER of ESCC between 2005 and 2018 at our institution. In this retrospective cohort study, we investigated the prognosis and predictors of early and late mortality with the cut-off value of 3 years. We enrolled 407 patients with a median 69 months follow-up. The 5-year overall survival and disease-specific survival, an indicator of ESCC-related mortality, were 83.4% and 98.4%, respectively. In multivariate Cox analyses, Eastern Cooperative Oncology Group performance status (ECOG-PS), consisting of six grades by a patient's level of activity, ≥ 2 was a predictor for early and late morality [hazard ratio (HR), 7.21 (P = 0.007) and 15.62 (P = 0.021), respectively]. Charlson comorbidity index (CCI), which is an index for predicting mortality by comorbid conditions, ≥ 2 was also a predictor for both mortality [HR, 2.97 (P = 0.017) and 1.90 (P = 0.019), respectively]. However, age was a predictor only for late mortality [HR, 3.08 (P = 0.010) in 80-84 years and 8.38 (P < 0.001) in ≥ 85 years]. Considering the predictive ability for early mortality, we propose that ECOG-PS and/or CCI are better indices compared with age in deciding treatment strategy after ER for ESCC.
Impaired Mucosal Integrity in Proximal Esophagus Is Involved in Development of Proton Pump Inhibitor-Refractory Nonerosive Reflux Disease. 国際誌査読有り

Kazuaki Norita, Kiyotaka Asanuma, Tomoyuki Koike, Tomoki Okata, Taku Fujiya, Yasuaki Abe, Kenichiro Nakagawa, Waku Hatta, Kaname Uno, Tomohiro Nakamura, Naoki Nakaya, Naoki Asano, Akira Imatani, Tooru Shimosegawa, Atsushi Masamune

Digestion　102　(3)　404-414　2021年

DOI： 10.1159/000508661 　

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BACKGROUND AND OBJECTIVE: Weakly acidic reflux reaching to the proximal esophagus is closely related to the perception of gastroesophageal reflux in patients with nonerosive reflux disease despite treatment with a proton pump inhibitor (PPI). However, little is known about the involvement of the patients' mucosal integrity of the proximal esophagus. METHODS: We recruited 15 symptomatic nonerosive gastroesophageal reflux disease (GERD) patients with a positive symptom index despite PPI treatment and 11 healthy asymptomatic volunteers as controls. The biopsy specimens obtained from the proximal and distal esophagus were applied to a mini-Ussing chamber system to measure transepithelial electrical resistance (TEER) against a pH 4 weak acid. The esophageal biopsy samples were subjected to quantitative real-time PCR and immunohistochemical analysis. RESULTS: In the proximal esophagus, the weak acid exposure reduced the TEER in the PPI-refractory patients compared to that in the controls. The frequency of the reflux extending to the proximal esophagus had a significant correlation with the reduction in the proximal esophageal TEER in the patients. The reduced TEER in the proximal esophagus was accompanied by an increase in IL-8 and IL-1β mRNA and a decrease in occludin mRNA levels. The proximal esophageal mucosa in the patients presented infiltration of CD3-positive lymphocytes and an increased expression of solute carrier organic anion transporter family member 2A1 (SLCO2A1), a passage gate of reflux symptom-evoking molecules. CONCLUSIONS: The reflux perception is related to an impairment of the proximal esophageal mucosal integrity in patients with nonerosive reflux disease despite PPI.
[Advanced Gastric Cancer with Tumor Shrinkage Persisting after the Discontinuation of Nivolumab-A Case Report].

Itaru Sato, Naoki Nakaya, Yoko Obara, Souichirou Ueno, Hideo Nakajima

Gan to kagaku ryoho. Cancer & chemotherapy　47　(12)　1715-1717　2020年12月

ISSN：0385-0684

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The patient was a 65-year-old man with advanced gastric cancer, cT4bN3aM1, cStage Ⅳ. The SOX therapy was administered as the primary treatment but discontinued after 9 courses because of disease progression. The PTX plus RAM therapy was then administered for 1 courses as the secondary treatment but discontinued because of the development of peritoneal dissemination, increased number of ascites, and increased number of lymph node metastases. The nivolumab(NIV)therapy was initiated as the tertiary treatment, but the patient complained of fatigue and diplopia after 2 courses. Ptosis was observed, and transaminase and creatine kinase levels were elevated. Electrocardiography showed complete right bundle branch block. The patient showed immune-related adverse events and was diagnosed with myocarditis and myasthenia gravis due to NIV. Consequently, systemic steroids were administered. Although 2 course of CPT-11 was administered as the fourth-line treatment, the treatment was discontinued upon the patient's request. Ten months after the discontinuation of chemotherapy, the disease showed no progression. The patient is being followed-up as an outpatient. Here, we reported a case of gastric cancer with tumor shrinkage after the discontinuation of NIV.
Impact of the Great East Japan Earthquake on the Employment Status and Mental Health Conditions of Affected Coastal Communities. 国際誌

Mitsuaki Katayanagi, Moe Seto, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Yumi Sugawara, Akira Kodaka, Yusuke Utsumi, Hitomi Usukura, Yasuto Kunii, Atsushi Hozawa, Ichiro Tsuji, Hiroaki Tomita

International journal of environmental research and public health　17　(21)　2020年11月3日

DOI： 10.3390/ijerph17218130 　

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The Great East Japan Earthquake devasted the old community in coastal areas characterized by primary industry. The number of unemployed people increased from 150,000 to 190,000 after the earthquake. All of the adult residents of Shichigahama (18 years old or older), located in the coastal area of the Miyagi prefecture, whose houses were totally or majorly damaged, were recruited for a survey conducted in October 2011. All of the residents who responded with written informed consent were included in this study. Among 904 individuals who had a job before the Great East Japan Earthquake, 19% became unemployed. Concerning gender and age, 9% of young men, 34% of elderly men, 21% of young women, and 49% of elderly women became unemployed. Concerning the type of industry, 38%, 15%, and 16% of people who had belonged to the primary, secondary, and tertiary industries, respectively, before the disaster became unemployed. Those who became unemployed exhibited a significantly higher risk of insomnia compared to those who maintained jobs. The study pointed out the severe impact of the Great East Japan Earthquake on populations who had belonged to the primary industry, especially among elderly women, and its effect on sleep conditions.
Hypertensive disorders of pregnancy, obesity, and hypertension in later life by age group: a cross-sectional analysis. 国際誌査読有り

Maiko Wagata, Mana Kogure, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Takumi Hirata, Akira Narita, Hirohito Metoki, Mami Ishikuro, Masahiro Kikuya, Kozo Tanno, Akimune Fukushima, Nobuo Yaegashi, Shigeo Kure, Masayuki Yamamoto, Shinichi Kuriyama, Atsushi Hozawa, Junichi Sugawara

Hypertension research : official journal of the Japanese Society of Hypertension　43　(11)　1277-1283　2020年11月

DOI： 10.1038/s41440-020-0463-8 　

ISSN：0916-9636

eISSN：1348-4214
Trends in cancer screening rates among individuals with serious psychological distress: an analysis of data from 2007 to 2016 Japanese national surveys

Masaki Fujiwara, Yuji Higuchi, Naoki Nakaya, Maiko Fujimori, Yuto Yamada, Riho Wada, Tsuyoshi Etoh, Kyoko Kakeda, Yosuke Uchitomi, Tomio Nakayama, Norihito Yamada, Masatoshi Inagaki

Journal of Psychosocial Oncology Research & Practice　2　(3)　e025-e025　2020年10月
出版者・発行元： Ovid Technologies (Wolters Kluwer Health)
DOI： 10.1097/or9.0000000000000025 　

eISSN：2637-5974
東日本大震災被災者の居住環境の変化による他者との交流習慣・メンタルヘルスへの影響

鈴木智美, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 中谷直樹, 寳澤篤, 辻一郎, 富田博秋

日本公衆衛生学会総会抄録集　79回　415-415　2020年10月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
Low birth weight and abnormal pre-pregnancy body mass index were at higher risk for hypertensive disorders of pregnancy. 国際誌査読有り

Maiko Wagata, Mami Ishikuro, Taku Obara, Masato Nagai, Satoshi Mizuno, Naoki Nakaya, Tomohiro Nakamura, Takumi Hirata, Naho Tsuchiya, Hirohito Metoki, Soichi Ogishima, Atsushi Hozawa, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama, Junichi Sugawara

Pregnancy hypertension　22　119-125　2020年10月

DOI： 10.1016/j.preghy.2020.08.001 　

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Low birth weight is known to be associated with hypertension, cardiovascular disease and hypertensive disorders of pregnancy (HDP); however, this association might vary by race/ethnicity. This study aimed to clarify the association between women's own birth weight and their subsequent risk for HDP in a Japanese population, in combination with pre-pregnancy body mass index (BMI). We conducted a cohort study as part of the Tohoku Medical Megabank Birth and Three-Generation Cohort Study in Miyagi, Japan. Our study's population included 4810 women. A multivariate logistic regression analysis was performed to calculate the adjusted odds ratio (aOR) and the 95% confidence interval (CI) of the women's own birth weight for HDP, in the combination categories of birth weight and pre-pregnancy BMI. As a result, the group with a low birth weight of <2500 g had a significant association with HDP (the aOR, 1.50; 95% CI, 1.02-2.21). In the subtype analysis, the odds ratio for only preeclampsia was significantly increased in the low birth weight group (aOR, 3.37; 95% CI, 1.84-6.16). In the group with a low birth weight, the prevalence of HDP was higher in both the underweight and overweight groups. In conclusion, there was a significant association between low birth weight and subsequent HDP in Japanese women. Furthermore, a significant association with HDP was found for women born with a low birth weight who were underweight or overweight as adults. Maintaining a normal weight may be effective for preventing HDP even if a woman was born small.
重度の心理的苦痛を抱える人々のがん検診受診率の経時的変化国民生活基礎調査データの解析

藤原雅樹, 樋口裕二, 中谷直樹, 藤森麻衣子, 山田裕士, 和田里穂, 江藤剛, 掛田恭子, 内富庸介, 中山富雄, 山田了士, 稲垣正俊

精神神経学雑誌　(2020特別号)　S578-S578　2020年9月
出版者・発行元： (公社)日本精神神経学会
ISSN：0033-2658
重度の心理的苦痛を抱える人々の喫煙率の経時的変化国民生活基礎調査データの解析

藤原雅樹, 樋口裕二, 中谷直樹, 藤森麻衣子, 山田裕士, 和田里穂, 江藤剛, 掛田恭子, 内富庸介, 山田了士, 稲垣正俊

精神神経学雑誌　(2020特別号)　S578-S578　2020年9月
出版者・発行元： (公社)日本精神神経学会
ISSN：0033-2658
Trends in smoking rates among individuals with serious psychological distress: Analysis of data from a Japanese national survey, 2007-2016. 国際誌査読有り

Yuji Higuchi, Masaki Fujiwara, Naoki Nakaya, Maiko Fujimori, Yuto Yamada, Riho Wada, Tsuyoshi Etoh, Kyoko Kakeda, Yosuke Uchitomi, Norihito Yamada, Masatoshi Inagaki

Psychiatry research　291　113225-113225　2020年9月

DOI： 10.1016/j.psychres.2020.113225 　

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To determine whether the downward trend in the smoking rate over time in Japan differs between individuals with and without serious psychological distress (SPD), we used nationally representative data sets from the 2007, 2010, 2013, and 2016 Comprehensive Survey of Living Conditions of Japan. SPD was defined as a score ≥ 13 on the six-item Kessler Psychological Distress Scale. We conducted multivariate logistic regression analyses including the interaction terms between SPD and survey year. A total 187,685 participants were included. The interaction terms between SPD and survey year among men were significant for 2010 and 2016 but not for 2013. Among women, the interaction terms between SPD and survey year were not significant for any year. In conclusion, we confirmed that the gap in the rate of smoking between men with SPD and those without SPD decreased from 2007 to 2016. Among women, the gap in the smoking rate between those with SPD and those without SPD remained unchanged. Our findings suggest a need for specific support strategies including pharmacological interventions, especially for women smokers with SPD. Further studies are warranted to identify factors contributing to these sex differences.
Reproducibility and reliability of performance indicators to evaluate the therapeutic effectiveness of biofeedback therapy after elbow surgery: An observational case series. 国際誌

Rina Takahashi, Kazufumi Sano, Kazumasa Kimura, Toshiyuki Ishioka, Makoto Suzuki, Naoki Nakaya, Satoru Ozeki, Toyohiro Hamaguchi

Medicine　99　(34)　e21889　2020年8月21日

DOI： 10.1097/MD.0000000000021889 　

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Electromyographic biofeedback (EMG-BF) therapy provides information on the state of contraction of the targeted muscles and relaxation of their antagonists, which can facilitate early active range of motion (RoM) after elbow surgery. Our aim in this study was to calculate the minimum detectable change (MDC) during EMG-BF therapy, initiated in the early postoperative period after elbow surgery.This study is an observational case series. EMG-BF of muscle contraction and relaxation was provided during active elbow flexion and extension exercises. Patients completed 3 sets of 10 trials each of flexion and extension over 4 weeks. The total range of flexion-extension motion and scores on the Japanese Society for Surgery of the Hand version of the disability of the arm, shoulder, and hand questionnaire and the Japanese version of the Patient-Rated Elbow Evaluation were obtained at baseline and weekly during the 4-week intervention period. A prediction formula was developed from the time-series data obtained during the intervention period, using the least-squares method. The estimated value was calculated by removing the slope from the prediction formula and adding the initial scores to residuals between the measured scores and predicted scores individually. Systematic error, MDC at the 95th percentile cutoff (MDC95), repeatability of the measures, and the change from the baseline to each time-point of intervention were assessed.The MDC95 was obtained for all 3 outcome measures and the range of values was as follows: RoM, 8.3° to 22.5°; Japanese version of the Patient-Rated Elbow Evaluation score, 17.6 to 30.6 points; and disability of the arm, shoulder, and hand questionnaire subscale: disability and symptoms score, 14.2 to 22.9 points.The efficacy of EMG-BF after elbow surgery was reflected in earlier initiation of elbow RoM after surgery and improvement in patient-reported upper limb function scores. The calculated MDC95 cut-offs could be used as reference values to assess the therapeutic effects of EMG-BF in individuals.
Viral delivery of multiple miRNAs promotes retinal ganglion cell survival and functional preservation after optic nerve crush injury. 国際誌

Ben Mead, Erin Cullather, Naoki Nakaya, Yuzhe Niu, Christo Kole, Zubair Ahmed, Stanislav Tomarev

Experimental eye research　197　108071-108071　2020年8月

DOI： 10.1016/j.exer.2020.108071 　

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Bone marrow mesenchymal stem cell (BMSC)-derived small extracellular vesicles (sEV) but not fibroblast sEV provide retinal ganglion cell (RGC) neuroprotection both in vitro and in vivo, with miRNAs playing an essential role. More than 40 miRNAs were more abundant in BMSC-sEV than in fibroblast-sEV. The purpose of this study was to test the in vitro and in vivo neuroprotective and axogenic properties of six candidate miRNAs (miR-26a, miR-17, miR-30c-2, miR-92a, miR-292, and miR-182) that were more abundant in BMSC-sEV than in fibroblast-sEV. Adeno-associated virus 2 (AAV2) expressing a combination of three of the above candidate miRNAs were added to heterogenous adult rat retinal cultures or intravitreally injected into rat eyes one week before optic nerve crush (ONC) injury. Survival and neuritogenesis of βIII-tubulin+ RGCs was assessed in vitro, as well as the survival of RBPMS+ RGCs and regeneration of their axons in vivo. Retinal nerve fiber layer thickness (RNFL) was measured to assess axonal density whereas positive scotopic threshold response electroretinography amplitudes provided a readout of RGC function. Qualitative retinal expression of PTEN, a target of several of the above miRNAs, was used to confirm successful miRNA activity. AAV2 reliably transduced RGCs in vitro and in vivo. Viral delivery of miRNAs in vitro showed a trend towards neuroprotection but remained insignificant. Delivery of selected combinations of miRNAs (miR-17-5p, miR-30c-2 and miR-92a; miR-92a, miR-292 and miR-182) before ONC provided significant therapeutic benefits according to the above measurable endpoints. However, no single miRNA appeared to be responsible for the effects observed, whilst positive effects observed appeared to coincide with successful qualitative reduction in PTEN immunofluorescence in the retina. Viral delivery of miRNAs provides a possible neuroprotective strategy for injured RGCs that is conducive to therapeutic manipulation.
非喫煙者における家庭での受動喫煙と高血圧の関連東北メディカル・メガバンク計画地域住民コホート調査より

平田匠, 小暮真奈, 成田暁, 土屋菜歩, 中村智洋, 目時弘仁, 中谷直樹, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

厚生の指標　67　(8)　1-8　2020年8月
出版者・発行元： (一財)厚生労働統計協会
ISSN：0452-6104
The Impact of Health Consciousness on the Association Between Walking Durations and Mental Health Conditions After a Disaster: a Cross-Sectional Study. 国際誌査読有り

Yusuke Utsumi, Harumi Nemoto, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Tomomi Suzuki, Moe Seto, Mitsuaki Katayanagi, Junko Okuyama, Atsushi Sakuma, Nami Honda, Yumi Sugawara, Halley Kaye-Kauderer, Yuta Takahashi, Akemi Kayama, Yoshihisa Kakuto, Masahiro Kohzuki, Atsushi Hozawa, Ichiro Tsuji, Hiroaki Tomita

Sports medicine - open　6　(1)　30-30　2020年7月16日

DOI： 10.1186/s40798-020-00259-6 　

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BACKGROUND: In communities affected by a disaster, walking can be a feasible form of physical exercise to improve physical and mental health conditions. However, there is limited evidence to support relationships between walking habits and mental health conditions in post-disaster settings. Cross-sectional epidemiological data obtained from a questionnaire survey (conducted in October 2017) of a community affected by the 2011 Great East Japan Earthquake (GEJE) was analyzed to evaluate the relationships. METHODS: Participants included individuals over 20 years of age (N = 718) from Shichigahama town in Miyagi prefecture, whose houses were significantly damaged by the GEJE. Their mental health conditions were assessed by the Kessler Psychological Distress Scale (K6), the Center for Epidemiologic Studies Depression Scale (CES-D), and the Impact of Event Scale-Revised (IES-R). Additionally, the questionnaire asked the participants spent duration walking on average and their walking purpose by the following items: (1) longer than 60 min per day, (2) between 30 and 60 min per day, or (3) less than 30 min per day, and whether they walked to maintain healthy living habits (health-conscious walkers) or merely for transportation without considering health consequences (non-health-conscious walkers). These information and mental health indicators were analyzed using analysis of covariance (ANCOVA). RESULTS: Among the three walking duration groups of health-conscious walkers, there were significant differences in CES-D and K6 scores (p = 0.01 and p = 0.04), but not in IES-R scores, considering age, gender, and alcohol drinking habits as covariates. CES-D score was significantly higher among short walkers (p = 0.004). Among the three walking duration groups of non-health-conscious walkers, there were significant differences in avoidance symptoms, the subdomain of IES-R (p = 0.01), but not in CES-D, K6, and total IES-R scores, considering the variants. CONCLUSION: Our study suggests that walking durations may positively affect mood, but not PTSR, only when walking is performed with the purpose of maintaining healthy living habits. Walking durations were negatively associated with avoidance symptoms among non-health-conscious walkers in the community affected by the GEJE, indicating that the disaster may have had a long-lasting impact on walking habits.
DERIVATION AND EXTERNAL VALIDATION OF A PREDICTION MODEL (BEST-J SCORE) OF BLEEDING AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION FOR EARLY GASTRIC CANCER 査読有り

Gastrointestinal Endoscopy,　91　(6)　AB585-AB586　2020年6月

DOI： 10.1016/j.gie.2020.03.3659 　
東北メディカル・メガバンク機構-地域住民コホート調査の進捗について

寳澤篤, 土屋菜歩, 平田匠, 小暮真奈, 成田暁, 中村智洋, 中谷直樹, 小原拓, 栗山進一, 菅原準一, 呉繁夫

宮城県公衆衛生学会会誌　(52)　20-20　2020年4月
出版者・発行元：宮城県公衆衛生学会
ISSN：0912-747X
東北メディカル・メガバンク機構-地域住民コホート調査の進捗について

寳澤篤, 土屋菜歩, 平田匠, 小暮真奈, 成田暁, 中村智洋, 中谷直樹, 小原拓, 栗山進一, 菅原準一, 呉繁夫

宮城県公衆衛生学会会誌　(52)　20-20　2020年4月
出版者・発行元：宮城県公衆衛生学会
ISSN：0912-747X
Activating Transcription Factor 3 (ATF3) Protects Retinal Ganglion Cells and Promotes Functional Preservation After Optic Nerve Crush. 国際誌

Christo Kole, Benedikt Brommer, Naoki Nakaya, Mohor Sengupta, Luis Bonet-Ponce, Tantai Zhao, Chen Wang, Wei Li, Zhigang He, Stanislav Tomarev

Investigative ophthalmology & visual science　61　(2)　31-31　2020年2月7日

DOI： 10.1167/iovs.61.2.31 　

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PURPOSE: To investigate the possible role of activating transcription factor 3 (ATF3) in retinal ganglion cell (RGC) neuroprotection and optic nerve regeneration after optic nerve crush (ONC). METHODS: Overexpression of proteins of interest (ATF3, phosphatase and tensin homolog [PTEN], placental alkaline phosphatase, green fluorescent protein) in the retina was achieved by intravitreal injections of recombinant adenovirus-associated viruses (rAAVs) expressing corresponding proteins. The number of RGCs and αRGCs was evaluated by immunostaining retinal sections and whole-mount retinas with antibodies against RNA binding protein with multiple splicing (RBPMS) and osteopontin, respectively. Axonal regeneration was assessed via fluorophore-coupled cholera toxin subunit B labeling. RGC function was evaluated by recording positive scotopic threshold response. RESULTS: The level of ATF3 is preferentially elevated in osteopontin+/RBPMS+ αRGCs following ONC. Overexpression of ATF3 by intravitreal injection of rAAV 2 weeks before ONC promoted RBPMS+ RGC survival and preserved RGC function as assessed by positive scotopic threshold response recordings 2 weeks after ONC. However, overexpression of ATF3 and simultaneous downregulation of PTEN, a negative regulator of the mTOR pathway, combined with ONC, only moderately promoted short distance RGC axon regeneration (200 μm from the lesion site) but did not provide additional RGC neuroprotection compared with PTEN downregulation alone. CONCLUSIONS: These results reveal a neuroprotective effect of ATF3 in the retina following injury and identify ATF3 as a promising agent for potential treatments of optic neuropathies.
Dietary Inflammatory Index Positively Associated With High-Sensitivity C-Reactive Protein Level in Japanese From NIPPON DATA2010. 査読有り

Yunqing Yang, Atsushi Hozawa, Mana Kogure, Akira Narita, Takumi Hirata, Tomohiro Nakamura, Naho Tsuchiya, Naoki Nakaya, Toshiharu Ninomiya, Nagako Okuda, Aya Kadota, Takayoshi Ohkubo, Tomonori Okamura, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura

Journal of epidemiology　30　(2)　98-107　2020年2月5日

DOI： 10.2188/jea.JE20180156 　

ISSN：0917-5040

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BACKGROUND: It has been reported that chronic inflammation may play an important role in the pathogenesis of several serious diseases and could be modulated by diet. Recently, the Dietary Inflammatory Index (DII®) was developed to assess the inflammatory potential of the overall diet. The DII has been reported as relevant to various diseases but has not been validated in Japanese. Thus, in the present study, we analyzed the relationship between DII scores and high-sensitivity C-reactive protein (hs-CRP) levels in a Japanese population. METHODS: Data of the National Integrated Project for Prospective Observation of Non-communicable Disease and its Trends in the Aged 2010 (NIPPON DATA2010), which contained 2,898 participants aged 20 years or older from the National Health and Nutrition Survey of Japan (NHNS2010), were analyzed. Nutrient intakes derived from 1-day semi-weighing dietary records were used to calculate DII scores. Energy was adjusted using the residual method. Levels of hs-CRP were evaluated using nephelometric immunoassay. Multiple linear regression analyses were performed. RESULTS: After adjusting for age, sex, smoking status, BMI, and physical activity, a significant association was observed between DII scores and log(CRP+1) (standard regression coefficient = 0.05, P < 0.01). Although it was not statistically significant, the positive association was consistently observed in almost all age-sex subgroups and the non-smoker subgroup. CONCLUSIONS: The current study confirmed that DII score was positively associated with hs-CRP in Japanese.
Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective. 国際誌査読有り

Shinichi Kuriyama, Hirohito Metoki, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Masato Nagai, Hiroko Matsubara, Tomoko Kobayashi, Junichi Sugawara, Gen Tamiya, Atsushi Hozawa, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Takumi Hirata, Ichiro Tsuji, Fuji Nagami, Nobuo Fuse, Tomohiko Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Yoichi Suzuki, Noriko Osumi, Keiko Nakayama, Kiyoshi Ito, Shinichi Egawa, Koichi Chida, Eiichi Kodama, Hideyasu Kiyomoto, Tadashi Ishii, Akito Tsuboi, Hiroaki Tomita, Yasuyuki Taki, Hiroshi Kawame, Kichiya Suzuki, Naoto Ishii, Soichi Ogishima, Satoshi Mizuno, Takako Takai-Igarashi, Naoko Minegishi, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Osamu Tanabe, Seizo Koshiba, Hiroaki Hashizume, Hozumi Motohashi, Teiji Tominaga, Sadayoshi Ito, Kozo Tanno, Kiyomi Sakata, Atsushi Shimizu, Jiro Hitomi, Makoto Sasaki, Kengo Kinoshita, Hiroshi Tanaka, Tadao Kobayashi, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto

International journal of epidemiology　49　(1)　18-19　2020年2月1日

DOI： 10.1093/ije/dyz169 　

ISSN：0300-5771
Correction: The effects of locomotor activity on gastrointestinal symptoms of irritable bowel syndrome among younger people: An observational study. 国際誌

Toyohiro Hamaguchi, Jun Tayama, Makoto Suzuki, Naoki Nakaya, Hirokazu Takizawa, Kohei Koizumi, Yoshifumi Amano, Motoyori Kanazawa, Shin Fukudo

PloS one　15　(12)　e0244465　2020年

DOI： 10.1371/journal.pone.0244465 　

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[This corrects the article DOI: 10.1371/journal.pone.0234089.].
The effects of locomotor activity on gastrointestinal symptoms of irritable bowel syndrome among younger people: An observational study. 国際誌査読有り

Toyohiro Hamaguchi, Jun Tayama, Makoto Suzuki, Naoki Nakaya, Hirokazu Takizawa, Kohei Koizumi, Yoshifumi Amano, Motoyori Kanazawa, Shin Fukudo

PloS one　15　(5)　e0234089　2020年

DOI： 10.1371/journal.pone.0234089 　

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Irritable bowel syndrome (IBS) is a common bowel disorder that manifests as unexplained abdominal pain or discomfort and bowel habit changes in the form of diarrhea, constipation, or alternating patterns of the two. Some evidences demonstrate that increased physical activity improves IBS symptoms. Hence, daily exercise is recommended in these patients. In this study, we aimed to investigate the relationship between physical activity and gastrointestinal symptoms in 101 university students (female = 78) with IBS. Participants were examined by Gastrointestinal Symptoms Rating Scale (GSRS), and gait steps were measured for 1 week using a pedometer. The association between the GSRS score and pedometer counts was determined by ordinal logistic modeling analysis. The ordinal logistic regression model for GSRS and locomotor activity showed a significant stepwise fit (z = -3.05, p = 0.002). The logistic curve separated GSRS score of 5 points (moderately severe discomfort) from 2 points (minor discomfort) by locomotor activity. The probability for daily locomotor activity to discriminate between 5 and 4 points of GSRS (i.e., likely to have reverse symptoms) decreased in accordance with increment of steps per day: 78% probability for 4000 steps, 70% probability for 6000 steps, 59% probability for 8000 steps, and 48% probability for 10000 steps. This study demonstrated that the severity of GSRS is associated with the amount of walking in younger people with IBS. These results may be used as a measure to determine the daily step count to reduce the severity of gastrointestinal symptoms in individuals with IBS.
Predicting recovery of upper extremity motor function after stroke according to the NovEl intervention Using Repetitive transcranial magnetic stimulation and Occupational therapy: NEURO. 査読有り

Hamaguchi T, Abo M, Tanaka T, Murata K, Suzuki M, Nakaya N, Taguchi K

Journal of Stroke Medicine　in press　2020年
Multiple measurements of the urinary sodium-to-potassium ratio strongly related home hypertension: TMM Cohort Study. 国際誌査読有り

Mana Kogure, Takumi Hirata, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Ken Miyagawa, Hiroshi Koshimizu, Taku Obara, Hirohito Metoki, Akira Uruno, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　43　(1)　62-71　2020年1月

DOI： 10.1038/s41440-019-0335-2 　

ISSN：0916-9636

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Previous studies have reported a positive association between the urinary sodium-to-potassium (Na/K) ratio and hypertension, and multiple measurements of the casual urinary Na/K ratio are more strongly correlated with the 24-h urinary Na/K ratio than a single measurement. Multiple measurements of the urinary Na/K ratio might be more strongly associated with hypertension. We aimed to determine the association between multiple measurements of the casual urinary Na/K ratio and home hypertension compared with a single measurement. A population-based cross-sectional study was performed in Miyagi Prefecture, Japan. Subjects were over 20 years old and participated in the Tohoku Medical Megabank Project Cohort Study. We targeted 3273 subjects who borrowed home blood pressure (HBP) monitors and urinary Na/K ratio monitors for 10 consecutive days. The association between the urinary Na/K ratio and home hypertension (HBP ≥ 135/85 mmHg or under treatment for hypertension) was examined using multiple logistic regression models. To compare the prediction of home hypertension using multiple measurements with that using a single measurement, we calculated the area under the receiver operating characteristic curve (AUROC). Multiple measurements of the urinary Na/K ratio strongly related to home hypertension were better than 1 or 2 days of measurement (adjusted odds ratio of home hypertension per unit increase in urinary Na/K ratio over 6 days: 1.13-1.15). The AUROC of the urinary Na/K ratio measurement for home hypertension was stable after 5 days (AUROC = 0.779). In conclusion, multiple measurements of the urinary Na/K ratio are strongly related to home hypertension. This finding suggests that multiple measurements of the urinary Na/K ratio are useful for evaluating home hypertension.
Reduced sleep efficiency, measured using an objective device, was related to an increased prevalence of home hypertension in Japanese adults. 国際誌査読有り

Takumi Hirata, Tomohiro Nakamura, Mana Kogure, Naho Tsuchiya, Akira Narita, Ken Miyagawa, Kotaro Nochioka, Akira Uruno, Taku Obara, Naoki Nakaya, Hirohito Metoki, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　43　(1)　23-29　2020年1月

DOI： 10.1038/s41440-019-0329-0 　

ISSN：0916-9636

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Few studies have reported the relationship between reduced sleep efficiency and the prevalence of hypertension independent of sleep duration in Japan. This study aimed to evaluate whether reduced sleep efficiency, measured using an objective device for >1 week, was related to an increased prevalence of hypertension independent of sleep duration in the general Japanese population. We conducted a cross-sectional study of 904 participants aged ≥20 years who lived in Miyagi Prefecture, Japan. Sleep efficiency was measured using a contactless biomotion sleep sensor for 10 continuous days. The participants were classified into two groups according to their sleep efficiency: reduced (<90%) or not reduced (≥90%). Hypertension was defined as morning home blood pressure ≥135/85 mmHg or self-reported treatment for hypertension. Multivariable logistic regression models were used to obtain odds ratios (ORs) and 95% confidence intervals (CIs) to assess the relationship between sleep efficiency and hypertension adjusted for potential confounders. The results showed that two hundred and ninety-four individuals (32.5%) had reduced sleep efficiency, and 331 (36.6%) had hypertension. Individuals with reduced sleep efficiency had a higher body mass index and shorter sleep duration. In the multivariable analysis, reduced sleep efficiency was significantly related to an increased prevalence of hypertension (OR, 1.62; 95% CI, 1.15-2.28). In conclusion, reduced sleep efficiency was significantly related to an increased prevalence of hypertension in Japanese adults. Improvements in sleep efficiency may be important to reduce blood pressure in Japanese adults.
Prefabricated Temporary Housing and Eczema or Respiratory Symptoms in Schoolchildren after the Great East Japan Earthquake: The ToMMo Child Health Study. 国際誌査読有り

Yasutaka Kuniyoshi, Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, Taku Obara, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Atsushi Hozawa, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Shinichi Kuriyama

Disaster medicine and public health preparedness　13　(5-6)　905-911　2019年12月

DOI： 10.1017/dmp.2019.8 　

ISSN：1935-7893

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OBJECTIVE: We aimed to investigate the association between types of housing and allergic symptoms at 3-4 years following the Great East Japan Earthquake. METHODS: Our study was based on the ToMMo Child Health Study conducted in 2014 and 2015, a cross-sectional survey of public school children in Miyagi Prefecture, Japan. Of the 46 648 invited schoolchildren in the 2nd to 8th grades, 9884 were included. Presence of eczema, wheezing, and mental health symptoms was defined with questionnaires. To calculate odds ratios (ORs) and 95% CIs for the associations between types of housing and eczema or respiratory symptoms, we fitted generalized linear mixed models, included a random effect for municipality of residence, and adjusted for sex, school grade, survey year, and mental health symptoms. RESULTS: Prefabricated temporary housing was significantly associated with eczema symptoms (OR, 1.46; 95% CI, 1.06-2.02). Even after adjusting for the presence of mental health symptoms, our analysis produced similar results (OR, 1.42; 95% CI, 1.03-1.96). Conversely, it was not significantly associated with respiratory symptoms (OR, 0.97; 95% CI, 0.61-1.54). CONCLUSIONS: Children living in prefabricated temporary housing had a higher prevalence of eczema symptoms; however, prevalence of respiratory symptoms was not significantly higher.
Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population. 国際誌査読有り

Siew-Kee Low, Yoon Ming Chin, Hidemi Ito, Keitaro Matsuo, Chizu Tanikawa, Koichi Matsuda, Hiroko Saito, Mika Sakurai-Yageta, Naoki Nakaya, Atsushi Shimizu, Satoshi S Nishizuka, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane, Toshiro Takezaki, Sadao Suzuki, Mariko Naito, Kenji Wakai, Yoichiro Kamatani, Yukihide Momozawa, Yoshinori Murakami, Johji Inazawa, Yusuke Nakamura, Michiaki Kubo, Toyomasa Katagiri, Yoshio Miki

Scientific reports　9　(1)　17332-17332　2019年11月22日

DOI： 10.1038/s41598-019-53654-9 　

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Genome-wide association studies (GWAS) have successfully identified about 70 genomic loci associated with breast cancer. Owing to the complexity of linkage disequilibrium and environmental exposures in different populations, it is essential to perform regional GWAS for better risk prediction. This study aimed to investigate the genetic architecture and to assess common genetic risk model of breast cancer with 6,669 breast cancer patients and 21,930 female controls in the Japanese population. This GWAS identified 11 genomic loci that surpass genome-wide significance threshold of P < 5.0 × 10-8 with nine previously reported loci and two novel loci that include rs9862599 on 3q13.11 (ALCAM) and rs75286142 on 21q22.12 (CLIC6-RUNX1). Validation study was carried out with 981 breast cancer cases and 1,394 controls from the Aichi Cancer Center. Pathway analyses of GWAS signals identified association of dopamine receptor medicated signaling and protein amino acid deacetylation with breast cancer. Weighted genetic risk score showed that individuals who were categorized in the highest risk group are approximately 3.7 times more likely to develop breast cancer compared to individuals in the lowest risk group. This well-powered GWAS is a representative study to identify SNPs that are associated with breast cancer in the Japanese population.
Change in smoking cessation stage over 1 year in patients with schizophrenia: a follow up study in Japan. 国際誌査読有り

Higuchi Y, Fujiwara M, Nakaya N, Fujimori M, Hayashibara C, So R, Shinkawa I, Sato K, Yada Y, Kodama M, Takenaka H, Kishi Y, Kakeda K, Uchitomi Y, Yamada N, Inagaki M

BMC psychiatry　19　(1)　367-367　2019年11月21日

DOI： 10.1186/s12888-019-2351-9 　
A randomised controlled trial of a case management approach to encourage participation in colorectal cancer screening for people with schizophrenia in psychiatric outpatient clinics: study protocol for the J-SUPPORT 1901 (ACCESS) study. 国際誌査読有り

Masaki Fujiwara, Masatoshi Inagaki, Taichi Shimazu, Masafumi Kodama, Ryuhei So, Takanori Matsushita, Yusaku Yoshimura, Shigeo Horii, Maiko Fujimori, Hirokazu Takahashi, Naoki Nakaya, Kyoko Kakeda, Tempei Miyaji, Shiro Hinotsu, Keita Harada, Hiroyuki Okada, Yosuke Uchitomi, Norihito Yamada

BMJ open　9　(11)　e032955　2019年11月2日

DOI： 10.1136/bmjopen-2019-032955 　

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INTRODUCTION: One of the reasons for the high mortality rate from cancer in people with schizophrenia is delay in diagnosis. Many studies have shown lower cancer screening rates in people with schizophrenia; however, there are no interventions for people with schizophrenia to increase cancer screening. Therefore, we developed a case management (CM) intervention to encourage participation in cancer screening. The purpose of this study was to examine the efficacy of CM to encourage participation in cancer screening for people with schizophrenia, with particular focus on colorectal cancer screening by faecal occult blood testing, compared with usual intervention (UI), namely, municipal public education. METHODS AND ANALYSIS: This is an individually randomised, parallel group trial with blinded outcome assessments. The participants will be randomly allocated to either the CM plus UI group or UI alone group in a 1:1 ratio using a web-based program at a data management centre. The primary end point of the study is participation in colorectal cancer screening in the year of intervention, which will be assessed based on municipal records. ETHICS AND DISSEMINATION: This study is performed in accordance with Ethical Guidelines for Medical and Health Research Involving Human Subjects published by Japan's Ministry of Education, Science, and Technology and the Ministry of Health, Labour, and Welfare and the modified Act on the Protection of Personal Information as well as the Declaration of Helsinki. This study was approved by the institutional ethics committee at the Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences and Okayama University Hospital on 23 April 2019 (approval number: RIN1904-003). The findings of this trial will be submitted to an international peer-reviewed journal. TRIAL REGISTRATION NUMBER: UMIN000036017.
TMM計画地域住民コホート調査(宮城)調査票項目と総死亡の関連

寳澤篤, 土屋菜歩, 平田匠, 成田暁, 小暮真奈, 中村智洋, 小原拓, 中谷直樹, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 布施昇男, 山本雅之

日本公衆衛生学会総会抄録集　78回　212-212　2019年10月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
6.3万人データ分譲に向けて東北メディカル・メガバンク計画地域住民コホート調査

土屋菜歩, 中村智洋, 平田匠, 成田暁, 小暮真奈, 村上慶子, 小原拓, 中谷直樹, 丹野高三, 坂田清美, 菅原準一, 栗山進一, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　78回　212-212　2019年10月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
遺伝因子と飲酒量の交互作用と随時血圧値の関連東北メディカル・メガバンク事業

成田暁, 中谷直樹, 小暮真奈, 田宮元, 中村智洋, 土屋菜歩, 平田匠, 丹野高三, 清水厚志, 菅原準一, 栗山進一, 辻一郎, 木下賢吾, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　78回　216-216　2019年10月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
睡眠の測定機器から得られた睡眠状況と心理的苦痛との関連

五十嵐有香, 小暮真奈, 中村智洋, 土屋菜歩, 平田匠, 成田暁, 宮川健, 宇留野晃, 中谷直樹, 菅原準一, 栗山進一, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　78回　223-223　2019年10月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
家庭での受動喫煙および能動喫煙の組み合わせと高血圧の関連

平田匠, 小暮真奈, 成田暁, 土屋菜歩, 中村智洋, 目時弘仁, 中谷直樹, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　78回　223-223　2019年10月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
特定健康診査時に尿ナトカリ計で2年連続測定した尿ナトリウム/カリウム比の変化と血圧への影響 COI東北拠点と宮城県登米市の共同研究

小暮真奈, 須藤庸子, 中村智洋, 土屋菜歩, 平田匠, 成田暁, 宮川健, 中谷直樹, 佐々木秀美, 本間洋子, 寳澤篤

日本高血圧学会総会プログラム・抄録集　42回　287-287　2019年10月
出版者・発行元： (NPO)日本高血圧学会
非喫煙者における受動喫煙の有無と家庭高血圧の関連

平田匠, 小暮真奈, 成田暁, 佐藤倫広, 土屋菜歩, 中村智洋, 宇留野晃, 小原拓, 目時弘仁, 中谷直樹, 菅原準一, 栗山進一, 呉繁夫, 寳澤篤

日本高血圧学会総会プログラム・抄録集　42回　288-288　2019年10月
出版者・発行元： (NPO)日本高血圧学会
配偶者同士の生活習慣の一致性とその年齢の影響 ToMMo 地域住民コホート調査査読有り

中谷直樹, 土屋菜歩, 成田暁, 石黒真美, 目時弘仁, 平田匠, 小暮真奈, 中村智洋, 後岡広太郎, 中谷久美, 辻一郎, 呉繁夫, 栗山進一, 寳澤篤

日本公衆衛生学会総会抄録集　78回　224-224　2019年10月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
TMM計画地域住民コホート調査(宮城)調査票項目と総死亡の関連査読有り

寳澤篤, 土屋菜歩, 平田匠, 成田暁, 小暮真奈, 中村智洋, 小原拓, 中谷直樹, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 布施昇男, 山本雅之

日本公衆衛生学会総会抄録集　78回　212-212　2019年10月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
6.3万人データ分譲に向けて東北メディカル・メガバンク計画地域住民コホート調査査読有り

土屋菜歩, 中村智洋, 平田匠, 成田暁, 小暮真奈, 村上慶子, 小原拓, 中谷直樹, 丹野高三, 坂田清美, 菅原準一, 栗山進一, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　78回　212-212　2019年10月
出版者・発行元：日本公衆衛生学会
ISSN：1347-8060
非喫煙者における受動喫煙の有無と家庭高血圧の関連査読有り

平田匠, 小暮真奈, 成田暁, 佐藤倫広, 土屋菜歩, 中村智洋, 宇留野晃, 小原拓, 目時弘仁, 中谷直樹, 菅原準一, 栗山進一, 呉繁夫, 寳澤篤

日本高血圧学会総会プログラム・抄録集　42回　288-288　2019年10月
出版者・発行元： (NPO)日本高血圧学会
Is Additional Surgery Always Sufficient for Preventing Recurrence After Endoscopic Submucosal Dissection with Curability C-2 for Early Gastric Cancer? 国際誌査読有り

Waku Hatta, Takuji Gotoda, Tsuneo Oyama, Noboru Kawata, Akiko Takahashi, Shiro Oka, Shu Hoteya, Masahiro Nakagawa, Masaaki Hirano, Mitsuru Esaki, Mitsuru Matsuda, Ken Ohnita, Ryo Shimoda, Motoyuki Yoshida, Osamu Dohi, Jun Takada, Keiko Tanaka, Shinya Yamada, Tsuyotoshi Tsuji, Hirotaka Ito, Hiroyuki Aoyagi, Tomohiro Nakamura, Naoki Nakaya, Tooru Shimosegawa, Atsushi Masamune

Annals of surgical oncology　26　(11)　3636-3643　2019年10月

DOI： 10.1245/s10434-019-07579-2 　

ISSN：1068-9265

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BACKGROUND: When a lesion does not meet the curative criteria of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC), referred to as non-curative resection or curability C-2 in the guidelines, an additional surgery is the standard therapy because of the risk of lymph node metastasis (LNM). OBJECTIVE: This study aimed to identify high-risk patients for recurrence after additional surgery for curability C-2 ESD of EGC. METHODS: This multicenter retrospective cohort study enrolled 1064 patients who underwent additional surgery after curability C-2 ESD for EGC. We evaluated the recurrence rate and the risk factors for recurrence after additional surgery in these patients. RESULTS: The 5-year recurrence rate after additional surgery was 1.3%. Multivariate Cox analysis revealed that the independent risk factors for recurrence after additional surgery were LNM (hazard ratio [HR] 32.47; p < 0.001) and vascular invasion (HR 4.75; p = 0.014). Moreover, patients with both LNM and vascular invasion had a high rate of recurrence after additional surgery (24.6% in 5 years), with a high HR (119.32) compared with those with neither LNM nor vascular invasion. Among patients with no vascular invasion, a high rate of recurrence was observed in those with N2/N3 disease according to the American Joint Committee on Cancer TNM staging system (27.3% in 5 years), in contrast with no recurrence in those with N1 disease. CONCLUSIONS: Patients with both LNM (N1-N3) and vascular invasion, as well as those with N2/N3 disease but no vascular invasion, would be candidates for adjuvant chemotherapy after additional surgery for curability C-2 ESD of EGC.
Continuous liquid-suction catheter attachment for endoscope reduces volume of liquid reflux to the mouth in esophageal endoscopic submucosal dissection. 国際誌査読有り

Waku Hatta, Tomoyuki Koike, Hideki Okata, Takashi Hanzawa, Masahiro Saito, Yutaka Kondo, Nobuyuki Ara, Kiyotaka Asanuma, Kaname Uno, Naoki Asano, Akira Imatani, Katsunori Iijima, Tomohiro Nakamura, Naoki Nakaya, Atsushi Masamune

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society　31　(5)　527-534　2019年9月

DOI： 10.1111/den.13392 　

ISSN：0915-5635

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BACKGROUND AND AIM: Pooling of liquid in the esophageal lumen can worsen the field of vision and cause liquid reflux to the mouth, which leads to aspiration pneumonia, in esophageal endoscopic submucosal dissection (ESD). We developed a continuous liquid-suction catheter attachment for the endoscope (CLCA) that has multiple tiny holes and can suction the liquid without causing mucosal injury. Thus, we aim to show the efficacy of CLCA in esophageal ESD. METHODS: This was a single-blinded, randomized controlled trial involving patients with superficial esophageal cancer. The enrolled patients were randomly assigned to the conventional ESD (C-ESD) or ESD with CLCA (CLCA-ESD) groups. Primary endpoint was volume of liquid reflux to the mouth during the ESD procedure. Secondary endpoints were incidence of aspiration pneumonia and procedure time. RESULTS: Fifty patients were enrolled in this trial. Volume of liquid reflux to the mouth was significantly lower in the CLCA-ESD group than in the C-ESD group (mean: 10 vs 73 mL, P = 0.010). Furthermore, the incidence of aspiration pneumonia on computed tomography (CT) scan between the two groups was also significantly different (4.0% vs 32.0%, P = 0.023), although no significant difference was observed through chest radiography. In addition, procedure time tended to be shorter in the CLCA-ESD group (P = 0.054). CONCLUSION: This study first showed that use of CLCA in esophageal ESD reduced the volume of liquid reflux to the mouth and contributed to decreased incidence of aspiration pneumonia on CT scan (UMIN000018167).
A training and education program for genome medical research coordinators in the genome cohort study of the Tohoku Medical Megabank Organization. 国際誌査読有り

Mika Sakurai-Yageta, Hiroshi Kawame, Shinichi Kuriyama, Atsushi Hozawa, Naoki Nakaya, Fuji Nagami, Naoko Minegishi, Soichi Ogishima, Takako Takai-Igarashi, Inaho Danjoh, Taku Obara, Mami Ishikuro, Tomoko Kobayashi, Yayoi Aizawa, Rino Ishihara, Masayuki Yamamoto, Yoichi Suzuki

BMC medical education　19　(1)　297-297　2019年8月2日

DOI： 10.1186/s12909-019-1725-5 　

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BACKGROUND: Genome cohort studies are used to analyze interactions between genetic and environmental factors, providing valuable information for personalized healthcare. Large-scale and long-term cohort studies require a number of specially trained personnel, of whom those involved in obtaining informed consent play a vital role, especially during the initial phase of such studies. The Japanese Society of Human Genetics (JSHG) previously established a certification system for genome medical research coordinators (GMRCs) responsible for obtaining written consent via face-to-face explanation. Meanwhile, in the Tohoku Medical Megabank Organization (ToMMo), GMRCs are expected to play important roles not only in obtaining informed consent and conducting various assessments, but also in communicating with participants throughout the long-term follow-up. Based on the JSHG program, we therefore developed a specific education and training program for ToMMo GMRCs consisting of 17 lectures, one practical training session on the informed consent procedure, and written and interview examinations. Re-education workshops aimed at self-improvement are also carried out following certification. In this study, we evaluated the education and training program in terms of overall understanding, usefulness, and satisfaction using an anonymous questionnaire. METHODS: An anonymous questionnaire addressing each aspect of the education and training program (understanding, usefulness, and satisfaction) was distributed among 152 qualified ToMMo GMRCs. Responses were received from 94 participants (61.8%). RESULTS: There was a significant association between the level of overall understanding of lectures and medical qualification (nurse or clinical laboratory technologist), but not with age or educational background. The level of understanding and overall usefulness were lower in sessions related to genetics and epidemiology than those dealing with ToMMo practices. In the re-education workshops, GMRCs showed a preference for and hoped to learn more about both background knowledge and research progress in the ToMMo. CONCLUSIONS: The results of our questionnaire suggest that not all ToMMo GMRCs are able to understand everything during the initial education and training program, especially in terms of genomic medicine. Continuous re-education is therefore vital in improving knowledge, skills and motivation, and preparing GMRCs for a specialist role in community-based personalized healthcare.
Association of Long-Term Treatment by Botulinum Neurotoxins and Occupational Therapy with Subjective Physical Status in Patients with Post-Stroke Hemiplegia. 国際誌査読有り

Toyohiro Hamaguchi, Masahiro Abo, Kai Murata, Mari Kenmoku, Izumi Yoshizawa, Atsushi Ishikawa, Makoto Suzuki, Naoki Nakaya, Kensuke Taguchi

Toxins　11　(8)　2019年8月2日

DOI： 10.3390/toxins11080453 　

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The short-term effects of botulinum toxin type A (BoNT-A) treatment in stroke patients with upper limb extremity are well established. This study examined the association between the recovery of motor function of the upper extremity with subjective physical symptoms in outpatients receiving long-term BoNT-A and occupational therapy following stroke. We also investigated the expectations of patients who elected to continue treatment. Forty-seven patients (23 men and 24 women) aged 61 years received BoNT-A treatment more than 20 times. The subjective physical status was analyzed by using the visual analogue scale score through an eight-item questionnaire. Recovery of motor function in the upper extremity was detected by calculating the change (delta) in Fugl-Mayer Assessment (FMA), and ordinal logistic modeling analysis was used to determine the association between the delta-FMA score and the subjective level of agreement for each item. When the ordinal logistic modeling fit was statistically significant, results were interpreted as having logistic probability. The logistic curves discriminating one point (strongly disagree) from five points (strongly agree) were fit in a stepwise fashion. This study suggests that patients receiving long-term BoNT-A treatment and occupational therapy experienced an increased upper extremity mitigation and decreased insomnia after injection, regardless of the recovery of motor function.
Spouse's functional disability and mortality: The Ohsaki Cohort 2006 Study. 査読有り

Toshimasa Sone, Naoki Nakaya, Yasutake Tomata, Kumi Nakaya, Masayuki Hoshi, Ichiro Tsuji

Geriatrics & gerontology international　19　(8)　774-779　2019年8月

DOI： 10.1111/ggi.13709 　

ISSN：1444-1586

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AIM: Caregiver burden is known to negatively affect a partner's health. Given the important role of physical and mental stress in mortality, a higher caregiver burden might be associated with an increased incidence of fatal events. However, previous studies of the effects of the partner's caregiving on mortality have shown inconsistent results. Thus, the purpose of the present longitudinal study was to determine if there is an association between a spouse's functional disability and mortality in the older Japanese population. METHODS: A baseline survey was carried out with 7598 participants in 2006. Information on the date of functional disability, death or emigration was retrieved from the Ohsaki City government. Functional disability was defined as receiving a certification for long-term care insurance in Japan. After a follow-up period of a maximum of 87 months, 1316 of the participants died and Cox regression analysis with adjustment for confounding factors was used to assess mortality after the incidence of functional disability in a spouse. RESULTS: The multivariate adjusted hazard ratio for mortality was 1.78 (95% confidence interval 1.52-2.08, P < 0.01) in those whose spouses had functional disabilities compared with those with spouses who did not have functional disabilities. The mortality was consistently higher, irrespective of age group or sex. CONCLUSIONS: These results imply that caregiver burden might increase stress responses and lead to increased mortality; therefore, enhancement of support systems, including long-term care, housing and livelihood support services, for those with disability and their spouses might be important for preventing deaths. Geriatr Gerontol Int 2019; 19: 774-779.
東日本大震災が沿岸地域の就労と精神的健康に及ぼした影響

片柳光昭, 富田博秋, 瀬戸萌, 根本晴美, 奥山純子, 鈴木智美, 菅原由美, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 小高晃, 辻一郎, 寳澤篤

精神神経学雑誌　(2019特別号)　S753-S753　2019年6月
出版者・発行元： (公社)日本精神神経学会
ISSN：0033-2658
精神科病院に通院中の統合失調症患者の禁煙ステージとその後の禁煙行動アンケートによる縦断調査査読有り

藤原雅樹, 樋口裕二, 稲垣正俊, 中谷直樹, 藤森麻衣子, 林原千夏, 宋龍平, 新川郁太, 佐藤康治郎, 矢田勇慈, 児玉匡史, 竹中央, 来住由樹, 掛田恭子, 内富庸介, 山田了士

精神神経学雑誌　(2019特別号)　S436-S436　2019年6月
出版者・発行元： (公社)日本精神神経学会
ISSN：0033-2658
一般地域住民における血清クレアチニンによる推定糸球体濾過量(eGFR)の季節差

良知弘務, 土屋菜歩, 平田匠, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 栗山進一, 菅原準一, 呉繁夫, 宮崎真理子, 寳澤篤

日本腎臓学会誌　61　(3)　332-332　2019年5月
出版者・発行元： (一社)日本腎臓学会
ISSN：0385-2385

eISSN：1884-0728
東北メディカル・メガバンク計画地域住民コホート進捗と今後の展望

寳澤篤, 丹野高三, 中谷直樹, 平田匠, 瀧靖之, 栗山進一, 菅原準一, 坂田清美, 辻一郎, 呉繁夫

日本老年医学会雑誌　56　(Suppl.)　106-106　2019年5月
出版者・発行元： (一社)日本老年医学会
ISSN：0300-9173
Construction of full-length Japanese reference panel of class I HLA genes with single-molecule, real-time sequencing 査読有り

Takahiro Mimori, Jun Yasuda, Yoko Kuroki, Tomoko F. Shibata, Fumiki Katsuoka, Sakae Saito, Naoki Nariai, Akira Ono, Naomi Nakai-Inagaki, Kazuharu Misawa, Keiko Tateno, Yosuke Kawai, Nobuo Fuse, Atsushi Hozawa, Shinichi Kuriyama, Junichi Sugawara, Naoko Minegishi, Kichiya Suzuki, Kengo Kinoshita, Masao Nagasaki, Masayuki Yamamoto

The Pharmacogenomics Journal　19　(2)　136-146　2019年4月19日
出版者・発行元： Springer Nature
DOI： 10.1038/s41397-017-0010-4 　

ISSN：1470-269X
東北メディカル・メガバンク計画地域住民コホート調査における糖尿病研究

平田匠, 寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐藤衛, 菊谷昌浩, 石垣泰, 坂田清美, 菅原準一, 栗山進一, 辻一郎, 呉繁夫

糖尿病　62　(Suppl.1)　S-304　2019年4月
出版者・発行元： (一社)日本糖尿病学会
ISSN：0021-437X

eISSN：1881-588X
Functional dyspepsiaにおけるchlorogenic acid増量かつhydroxyhydroquinone減量コーヒー飲料と通常コーヒー摂取時のディスペプシア症状ならびにglucagon-like peptide-1(GLP-1)への影響査読有り

庄司知隆, 矢神里紗, 中谷直樹, 中村智洋, 遠藤由香, 佐藤康弘, 町田知美, 町田貴胤, 鹿野理子, 金澤素, 中谷久美, 村椿智彦, 相澤祐一, 小室葉月, 佐々木彩加, 竹下尚男, 水野智仁, 渡辺卓也, 福土審

心身医学　59　(3)　267-267　2019年4月
出版者・発行元： (一社)日本心身医学会
ISSN：0385-0307
Functional dyspepsiaにおけるchlorogenic acid増量かつhydroxyhydroquinone減量コーヒー飲料と通常コーヒー摂取時の味覚ならびに気分への影響査読有り

矢神里紗, 庄司知隆, 中谷直樹, 中村智洋, 遠藤由香, 佐藤康弘, 町田知美, 町田貴胤, 鹿野理子, 金澤素, 中谷久美, 村椿智彦, 相澤祐一, 小室葉月, 佐々木彩加, 竹下尚男, 水野智仁, 渡辺卓也, 福土審

心身医学　59　(3)　267-267　2019年4月
出版者・発行元： (一社)日本心身医学会
ISSN：0385-0307
All-cause mortality among Japanese whose cohabiting partners are diagnosed with cancer: the Ohsaki Cohort 2006 study. 国際誌査読有り

Naoki Nakaya, Toshimasa Sone, Yasutake Tomata, Kumi Nakaya, Masayuki Hoshi, Ken Shimizu, Ichiro Tsuji

Acta oncologica (Stockholm, Sweden)　58　(4)　425-431　2019年4月

DOI： 10.1080/0284186X.2018.1562208 　

ISSN：0284-186X

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BACKGROUND: It has been noted that not only adverse psychosocial health effects but also mortality might increase for a person living with a spouse with cancer. This study examined the association between a partner's cancer diagnosis and mortality among a Japanese population. METHODS: In December 2006, a survey was conducted on participants aged 40 years or older who were residing in northeastern Japan. We identified couples using municipality-specific household ID numbers by searching public records and confirmed partner's cancer diagnosis after the baseline measurement using regional cancer registration information. After following up for a maximum of 4.0 years with the participants regarding mortality and emigration by reviewing the Residential Registry Record, we used Cox's proportional hazards regression to estimate the hazard ratio (HR) of all-cause mortality. RESULTS: We identified 25,938 participants (12,969 pairs) and included them in the analyses. A total of 1,308 (5.0%) participants had partners with a cancer diagnosis after baseline. The study found no association between a partner's cancer diagnosis and all-cause mortality; multivariable HRs of all-cause mortality for individuals in exposed subjects compared with those in unexposed subjects were 1.35 (95% confidence interval [CI] = 0.99-1.83; p = .055). Contrarily, sensitivity analyses of mortality attributed to having partners diagnosed with cancer based on the time since entry showed that all-cause mortality significantly increased only within one year from spouse cancer diagnosis; HR = 2.18 (95% CI = 1.44-3.30; p < .01). CONCLUSIONS: Our findings reveal that the mortality rate from partner's cancer diagnosis was significantly high during the early period of diagnosis and multidisciplinary teams for cancer treatment might be important for preventing death among the partner.
成人における客観的睡眠効率と高血圧有病率との関連(Association of Objective Sleep Efficiency with Prevalence of Hypertension in Adults) 査読有り

平田匠, 中村智洋, 小暮真奈, 成田暁, 宮川健, 後岡広太郎, 土屋菜歩, 小原拓, 中谷直樹, 栗山進一, 寳澤篤

日本循環器学会学術集会抄録集　83回　OJ22-4　2019年3月
出版者・発行元： (一社)日本循環器学会
Omega-3 polyunsaturated fatty acids and psychological intervention for workers with mild to moderate depression: A double-blind randomized controlled trial. 国際誌査読有り

J Tayama, S Ogawa, N Nakaya, T Sone, T Hamaguchi, A Takeoka, K Hamazaki, H Okamura, J Yajima, M Kobayashi, M Hayashida, S Shirabe

Journal of affective disorders　245　364-370　2019年2月15日

DOI： 10.1016/j.jad.2018.11.039 　

ISSN：0165-0327

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BACKGROUND: This study assessed whether a combined intervention of omega-3 polyunsaturated fatty acids (PUFAs) and psychoeducation better improved mild to moderate depression in workers compared to psychoeducation alone. METHODS: This study was a double-blinded, parallel group, randomized controlled trial that compared the intervention group, receiving omega-3 fatty acids, with a control group, receiving a placebo supplement. Participants receiving omega-3 fatty acids took 15 × 300 mg capsules per day for 12 weeks. The total daily dose of omega-3 PUFAs was 500 mg docosahexaenoic acid and 1000 mg eicosapentaenoic acid (EPA). The Beck Depression Inventory®-II (BDI-II) was used to assess the severity of depression after treatment. RESULTS: After 12 weeks of treatment, BDI-II scores were significantly lower in the placebo and omega-3 group, when compared to their respective baseline scores (Placebo: t = - 4.6, p < 0.01; Omega-3: t = - 7.3, p < 0.01). However, after 12 weeks of treatment, we found no significant difference between both groups with respect to changes in the BDI-II scores (0.7; 95% CI, - 0.7 to 2.1; p = 0.30). LIMITATIONS: This study did not measure blood omega-3 fatty acid concentration and presented a high-dropout rate. Moreover, our results may not be generalizable to other regions. CONCLUSIONS: The results show that a combination of omega-3 fatty acids and psychoeducation and psychoeducation alone can contribute to an improvement in symptoms in people with mild to moderate depression. However, there is no difference between the interventions in ameliorating symptoms of depression.
Support vector machine-based classifier for the assessment of finger movement of stroke patients undergoing rehabilitation. 査読有り

Hamaguchi T, Saito T, Suzuki M, Ishioka T, Tomisawa Y, Nakaya N, Abo M

J Med Biol Eng　40　(1)　in press-100　2019年
出版者・発行元：
DOI： 10.1007/s40846-019-00491-w 　

ISSN：1609-0985

eISSN：2199-4757
Differences between Japan and Taiwan in the treatment of pregnant women with depressive symptoms by omega-3 fatty acids: An open-label pilot study. 国際誌査読有り

Daisuke Nishi, Kuan-Pin Su, Kentaro Usuda, Jane Pei-Chen Chang, Yi-Ju Jill Chiang, Tai-Wei Guu, Kei Hamazaki, Naoki Nakaya, Toshimasa Sone, Kenji Hashimoto, Tomohito Hamazaki, Yutaka J Matsuoka

Nutritional neuroscience　22　(1)　63-71　2019年1月

DOI： 10.1080/1028415X.2017.1354540 　

ISSN：1028-415X

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OBJECTIVES: Although safe approaches for improving depression in pregnancy are required and the efficacy of omega-3 polyunsaturated fatty acids (PUFAs) has been suggested, the amount of supplemental omega-3 PUFAs has varied among previous studies and adequate amount might be different among countries. The aim of this pilot study is to explore the feasibility of using 1800 mg of omega-3 PUFAs supplementation for our future double-blind, placebo-control trial, and to clarify the clinical difference and the similarity between two sites of Japan and Taiwan. METHODS: Pregnant women between 12 and 24 weeks' gestation with depressive symptoms were recruited. Participants were supplemented daily with omega-3 PUFAs capsules containing 1206 mg eicosapentaenoic acid and 609 mg docosahexaenoic acid for 12 weeks. The primary outcome was change in total score on the 17-item Hamilton Rating Scale for Depression (HAMD) at 12 weeks after supplementation. RESULTS: Eight pregnant women in Japan and five in Taiwan participated in the study. A substantial proportion of pregnant women reported high consumption of omega-3 supplements and dietary fish were excluded in Taiwan rather than in Japan sites. The decrease in HAMD score from baseline to 12 weeks after the start of the intervention was significantly larger in Japanese participants than in Taiwanese participants (Wilcoxon rank sum test; P = 0.045). DISCUSSION: The improvement of depressive symptoms was smaller at the Taiwan site than at the Japan site. Differences in psychopathology of recruited participants identified by self-rating scales might affect the degree of population heterogeneity and the treatment efficacy. A randomized-controlled trial is needed to confirm these findings. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01948596.
The Efficacy of Omega-3 Fatty Acids for Depressive Symptoms among Pregnant Women in Japan and Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial (SYNCHRO; NCT01948596). 国際誌査読有り

Daisuke Nishi, Kuan-Pin Su, Kentaro Usuda, Jane Pei-Chen Chang, Yi-Ju Chiang, Hui-Ting Chen, Yu-Chuan Chien, Tai-Wei Guu, Emi Okazaki, Kei Hamazaki, Ryoko Susukida, Naoki Nakaya, Toshimasa Sone, Yo Sano, Hiroe Ito, Keiichi Isaka, Yoshiyuki Tachibana, Shinji Tanigaki, Tomo Suzuki, Kenji Hashimoto, Tomohito Hamazaki, Yutaka J Matsuoka

Psychotherapy and psychosomatics　88　(2)　122-124　2019年

DOI： 10.1159/000495296 　

ISSN：0033-3190
Estimation of Motor Impairment and Usage of Upper Extremities during Daily Living Activities in Poststroke Hemiparesis Patients by Observation of Time Required to Accomplish Hand Dexterity Tasks. 国際誌査読有り

Tomoko Tanaka, Toyohiro Hamaguchi, Makoto Suzuki, Daigo Sakamoto, Junpei Shikano, Naoki Nakaya, Masahiro Abo

BioMed research international　2019　9471921-9471921　2019年

DOI： 10.1155/2019/9471921 　

ISSN：2314-6133

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Aim: This study evaluated whether specific actual performance could accurately predict body function levels and upper limb use in the real-life functioning of poststroke hemiparesis patients to aid in choosing the most appropriate rehabilitation exercises. Methods: We measured the time taken for poststroke patients to move small objects with the paralyzed hand and investigated how the measurement could estimate upper extremity motor impairment and hand usage during activities of daily living (ADL). We examined 86 stroke patients (age 66 ± 16 years) whose upper extremity motor paralysis was measured using the Fugl-Meyer assessment (FMA) and Southampton Hand Assessment Procedure (SHAP), and patient-reported ADL was investigated using the Jikei Assessment Scale for Motor Impairment in Daily Living (JASMID). To identify the time required to perform each SHAP item, we employed a linear regression analysis. The prediction formula was used in the linear regression analysis, and the coefficient of determination (R 2) was applied to compare each component item score that was obtained with the predicted values derived from the linear regression analysis. Results: The most easily accomplished task was Heavy Power in the SHAP. The R 2 between the SHAP Heavy Power item score and the FMA scores was moderate (R 2 = 0.344, P < 0.0001), whereas the R 2 with the JASMID score was low (R 2 = 0.126, P < 0.001). Conclusions: By measuring the time it takes for poststroke hemiparesis patients to hold and move an object, we developed a prediction formula for upper extremity motor function and hand dexterity.
Immunohistochemical pattern of c-MYC protein judged as '+/(weak)+/-' by a new notation correlates with MYC gene non-translocation in large B-cell lymphoma. 国際誌査読有り

Fujishima F, Katsushima H, Fukuhara N, Konosu-Fukaya S, Nakamura Y, Usubuchi H, Sato S, Ota Y, Yashima-Abo A, Nakamura T, Nakaya N, Harigae H, Sasano H, Ichinohasama R

Human pathology　85　112-118　2018年11月

DOI： 10.1016/j.humpath.2018.10.025 　

ISSN：0046-8177
Different risk factors between early and late cancer recurrences in patients without additional surgery after noncurative endoscopic submucosal dissection for early gastric cancer. 国際誌査読有り

Yamada S, Hatta W, Shimosegawa T, Takizawa K, Oyama T, Kawata N, Takahashi A, Oka S, Hoteya S, Nakagawa M, Hirano M, Esaki M, Matsuda M, Nakaya N, Gotoda T

Gastrointestinal endoscopy　89　(5)　950-960　2018年11月

DOI： 10.1016/j.gie.2018.11.015 　

ISSN：0016-5107
Smoking among adults with serious psychological distress: Analysis of anonymized data from a national cross-sectional survey in Japan. 国際誌査読有り

Masaki Fujiwara, Masatoshi Inagaki, Naoki Nakaya, Maiko Fujimori, Yuji Higuchi, Kyoko Kakeda, Yosuke Uchitomi, Norihito Yamada

Journal of affective disorders　239　131-137　2018年10月15日

DOI： 10.1016/j.jad.2018.07.008 　

ISSN：0165-0327

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BACKGROUND: Smoking behavior among people with serious psychological distress (SPD) has not been fully investigated in Asia, although smoking has become a public health concern worldwide. Many Western population-based studies indicate that people with psychological distress are more likely to smoke. METHODS: This study used a national representative data set from the 2010 Comprehensive Survey of Living Conditions of Japan. SPD was defined as scores ≥13 or greater on the Kessler Psychological Distress Scale (K6). Multivariate logistic regression analyses were conducted to analyze the association between SPD and current smoking in Japanese adults. RESULTS: In both men (n = 27,937) and women (n = 30,786), SPD was significantly associated with current smoking (adjusted odds ratios [95% confidence intervals]: 1.169 [1.030-1.328] for men and 1.677 [1.457-1.931] for women). Among men, SPD was significantly associated with current smoking only in people aged ≥50 years (1.519 [1.232-1.874]) and married (1.456 [1.228-1.728]). SPD was significantly associated with current smoking in women of all ages. SPD had a greater impact on current smoking for women aged 20-49 years than for those aged ≥50 years (1.832 [1.552-2.162] and 1.445 [1.099-1.900], respectively). LIMITATIONS: The cross-sectional design precludes assumptions about the direction of causality. In addition, smoking status was self-reported. CONCLUSIONS: SPD was significantly associated with current smoking in Japan and the association was much stronger for younger women. Clinical strategies are needed to reduce the prevalence of smoking among people with SPD to reduce excess mortality in this population.
Severity of eczema and mental health problems in Japanese schoolchildren: The ToMMo Child Health Study. 国際誌査読有り

Yasutaka Kuniyoshi, Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, Taku Obara, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Atsushi Hozawa, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama

Allergology international : official journal of the Japanese Society of Allergology　67　(4)　481-486　2018年10月

DOI： 10.1016/j.alit.2018.02.009 　

ISSN：1323-8930

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BACKGROUND: The association between eczema and mental health problems in schoolchildren has been underexplored. We aimed to investigate this association with the validated questionnaires. METHODS: Of 46,648 invited children, we analyzed 9954 (21.3%) in the 2nd to the 8th grades from the ToMMo Child Health Study conducted in 2014 and 2015, a cross-sectional survey in Miyagi Prefecture, Japan. We defined eczema status as "normal," "mild/moderate," or "severe," based on the presence of persistent flexural eczema and sleep disturbance, according to the International Study of Asthma and Allergies in Childhood (ISAAC) Eczema Symptom Questionnaire. Clinical ranges of Strengths and Difficulties Questionnaire (SDQ) total difficulties scores and four SDQ subcategories of emotional symptoms, conduct problems, hyperactivity/inattention, and peer problems were defined as scores ≥16, ≥5, ≥5, ≥7, and ≥5, respectively. RESULTS: The mean SDQ total difficulties score significantly increased as eczema status worsened (all P ≤ 0.004 for trend). The OR of scores in the clinical range for SDQ total difficulties were 1.51 (95% CI, 1.31-1.74) for mild/moderate eczema and 2.63 (95% CI, 1.91-3.63) for severe eczema (P < 0.001 for trend), adjusted for sex, school grade, current wheeze, and disaster-related factors, using normal eczema as a reference. The association between severity of eczema and four SDQ subcategories showed a similar trend (all P ≤ 0.017 for trend). CONCLUSIONS: We found a significant association between severity of eczema and mental health problems. The presence of eczema was associated with four SDQ subcategories.
Functional disability among partners and community activity in elderly Japanese: The Ohsaki Cohort 2006 Study 査読有り

Toshimasa Sone, Naoki Nakaya, Yasutake Tomata, Masayuki Hoshi, Ichiro Tsuji

Archives of Gerontology and Geriatrics　78　150-154　2018年9月1日
出版者・発行元： Elsevier Ireland Ltd
DOI： 10.1016/j.archger.2018.06.007 　

ISSN：1872-6976 0167-4943

eISSN：1872-6976
Effect of tsunami drill experience on evacuation behavior after the onset of the Great East Japan Earthquake 査読有り

Naoki Nakaya, Harumi Nemoto, Carine Yi, Ayako Sato, Kotomi Shingu, Tomoka Shoji, Shosuke Sato, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Yumi Sugawara, Zhiqian Yu, Nicole Gunawansa, Shinichi Kuriyama, Osamu Murao, Takeshi Sato, Fumihiko Imamura, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

International Journal of Disaster Risk Reduction　28　206-213　2018年6月1日

DOI： 10.1016/j.ijdrr.2018.02.037 　

ISSN：2212-4209
KIWIFRUIT CAN REDUCE WHOLE GUT TRANSIT AND SYMPTOMS IN PATIENTS WITH FUNCTIONAL CONSTIPATION AND PATIENTS WITH IRRITABLE BOWEL SYNDROME WITH CONSTIPATION 査読有り

Okawa Yohei, Nakaya Kumi, Muratsubaki Tomohiko, Okamoto Tomoko, Fuda Mikiko, Endo Yuka, Kano Michiko, Kanazawa Motoyori, Nakaya Naoki, Barbara Giovanni, Gearry Richard B, Ansell Juliet, Kuhn-Sherlock Barbara, Drummond Lynley, Fukudo Shin

GASTROENTEROLOGY　154　(6)　S977　2018年5月

DOI： 10.1016/S0016-5085(18)33283-9 　

ISSN：0016-5085
Risk of psychological distress in partners with functional disability among older Japanese adults. 査読有り

Toshimasa Sone, Naoki Nakaya, Yasutake Tomata, Ichiro Tsuji

Geriatrics & gerontology international　18　(5)　775-782　2018年5月

DOI： 10.1111/ggi.13254 　

ISSN：1444-1586

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AIM: The present cross-sectional study aimed to evaluate the association of psychological distress with a partner's disability in an older Japanese population, as well as the effect modification of social support on this association. METHODS: The baseline survey was carried out between 1 December and 15 December 2006, and included 6809 participants from whom we collected data regarding functional disability and psychological distress. We defined functional disability as certification for long-term care insurance in Japan, and psychological distress as a Kessler 6 score of ≥10 out of 24. A multiple logistic regression analysis was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for increased psychological distress according to the categories of functional disability among partners. Stratified analyses were also carried out to investigate whether social support significantly affected the association between a partner's functional disability and psychological distress. RESULTS: The multiple-adjusted OR for psychological distress was 1.48 (95% CI 1.06-2.04) among participants whose partners had functional disabilities (vs those whose partners did not have functional disabilities). In the social support-stratified analysis, a significant association with psychological distress was observed among participants lacking social support for help with their daily housework (OR 2.47, 95% CI 1.23-4.83), but not among those with social support (OR 1.18, 95% CI 0.79-1.72); P for interaction = 0.03). CONCLUSIONS: A partner with functional disability conferred a significantly higher risk of psychological distress on older Japanese individuals, and this association was modified by social support. We conclude that social support might buffer psychological distress in this population. Geriatr Gerontol Int 2018; 18: 775-782.
Is the eCura system useful for selecting patients who require radical surgery after noncurative endoscopic submucosal dissection for early gastric cancer? A comparative study 査読有り

Waku Hatta, Takuji Gotoda, Tsuneo Oyama, Noboru Kawata, Akiko Takahashi, Yoshikazu Yoshifuku, Shu Hoteya, Masahiro Nakagawa, Masaaki Hirano, Mitsuru Esaki, Mitsuru Matsuda, Ken Ohnita, Kohei Yamanouchi, Motoyuki Yoshida, Osamu Dohi, Jun Takada, Keiko Tanaka, Shinya Yamada, Tsuyotoshi Tsuji, Hirotaka Ito, Yoshiaki Hayashi, Tomohiro Nakamura, Naoki Nakaya, Tooru Shimosegawa

Gastric Cancer　21　(3)　481-489　2018年5月1日
出版者・発行元： Springer Tokyo
DOI： 10.1007/s10120-017-0769-7 　

ISSN：1436-3305 1436-3291
訪問・通所リハビリテーション利用者の特性と課題に関する実態調査査読有り

曽根稔雅, 中谷直樹, 遠又靖丈, 辻一郎, 川越雅弘

厚生の指標　65　(3)　1-8　2018年3月
The Association between Woman's Own Birth Weight and Her Subsequent Risk for Hypertensive Disorders of Pregnancy. 査読有り

Wagata Maiko, Tsuchiya Naho, Nakaya Naoki, Ishikuro Mami, Metoki Hirohito, Hozawa Atsushi, Kuriyama Shinichi, Yaegashi Nobuo, Sugawara Junichi

REPRODUCTIVE SCIENCES　25　240A　2018年3月

ISSN：1933-7191
Low Cancer Screening Rates among Japanese People with Schizophrenia: A Cross-Sectional Study. 査読有り

Masatoshi Inagaki, Masaki Fujiwara, Naoki Nakaya, Maiko Fujimori, Yuji Higuchi, Chinatsu Hayashibara, Ryuhei So, Kyoko Kakeda, Masafumi Kodama, Yosuke Uchitomi, Norihito Yamada

The Tohoku journal of experimental medicine　244　(3)　209-218　2018年3月

DOI： 10.1620/tjem.244.209 　

ISSN：0040-8727

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Health care disparities among people with schizophrenia is a global concern. Our previous study revealed cancer screening rates in Japanese people with schizophrenia lower than rates of approximately 40% of the general population. However, that study was based on self-reports, which can be inaccurate, and rates did not differentiate the types of cancer screening provider (i.e., municipal screening, collective opportunistic screening, and individual opportunistic screening). This study aimed to investigate records-based cancer screening rates, focusing on participation rates of people with schizophrenia who are subject to municipal cancer screening programs. We conducted a cross-sectional study at a psychiatric hospital outpatient clinic from September to November 2016. We randomly extracted 420 potential participants from among 680 eligible patients and asked them to participate. We then selected subgroups of participants living in Okayama city who were enrolled in the National Health Insurance or Public Assistance systems and were subject to colorectal, gastric, lung, breast, or cervical cancer screening provided by Okayama city (n = 97, 96, 97, 42, and 64, respectively). Participation in cancer screenings was assessed based on local government records. Municipal cancer screening rates were as follows: 13.4% (95% confidence interval: 6.6%-20.2%) for colorectal, 7.3% (2.1%-12.5%) for gastric, 16.5% (9.1%-23.9%) for lung, 21.4% (9.0%-33.8%) for breast, and 14.1% (5.6%-22.6%) for cervical cancers. The findings demonstrated extremely low cancer screening rates among people with schizophrenia subject to municipal cancer screenings in Japan. A strategy to promote municipal cancer screening for people with schizophrenia is needed.
Association between serious psychological distress and nonparticipation in cancer screening and the modifying effect of socioeconomic status: Analysis of anonymized data from a national cross-sectional survey in Japan. 国際誌査読有り

Masaki Fujiwara, Masatoshi Inagaki, Naoki Nakaya, Maiko Fujimori, Yuji Higuchi, Kyoko Kakeda, Yosuke Uchitomi, Norihito Yamada

Cancer　124　(3)　555-562　2018年2月1日

DOI： 10.1002/cncr.31086 　

ISSN：0008-543X

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BACKGROUND: It is unclear whether individuals who have serious psychological distress (SPD) are less likely to participate in screening tests for gastric cancer, lung cancer, and other types of cancer. Of the few studies that have examined the association between SPD and participation in cancer screening, none have reported modifying effects of educational, marital, or employment status. METHODS: The authors analyzed a national representative data set from the 2010 Comprehensive Survey of Living Conditions of Japan., including individuals aged <69 years who met the national program criteria for each type of cancer screening (colorectal, gastric, and lung cancers, n = 29,926; breast cancer, n = 15,423; and cervical cancer, n = 24,735). SPD was defined as a score of 13 or greater on the Kessler 6 scale. Logistic regression analyses were conducted to examine the association between SPD and participation in cancer screening, and multivariate analyses stratified by socioeconomic status also were conducted. RESULTS: SPD was significantly associated with a lower odds ratio (OR) for participation in screening for colorectal cancer (OR, 0.743; 95% confidence interval [CI], 0.638-0.866), gastric cancer (OR, 0.823; 95% CI, 0.717-0.946), and lung cancer (OR, 0.691; 95% CI, 0.592-0.807). Only educational status significantly modified the effect of SPD on participation in these 3 types of cancer screening (P < .05). CONCLUSIONS: Individuals with SPD, especially those with lower education levels, were less likely to participate in screening for colorectal, gastric, and lung cancers. Individuals with SPD should be encouraged and supported to participate in cancer screening tests. Cancer 2018;124:555-62. © 2017 American Cancer Society.
東日本大震災における軽度身体的外傷と心理的苦痛の関連：七ヶ浜健康増進プロジェクト査読有り

成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 辻一郎, 寳澤篤, 富田博秋

日本公衆衛生雑誌　65　(4)　157-163　2018年
出版者・発行元：日本公衆衛生学会
DOI： 10.11236/jph.65.4_157 　

ISSN：0546-1766

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目的自然災害による身体的外傷がメンタルヘルスに与える影響に関する研究はこれまでにも報告されているが，軽度の身体的外傷においてもメンタルヘルスと関連するかはほとんど検証されていない。本研究は，東日本大震災に起因する軽度身体的外傷と心理的苦痛の関連を横断研究デザインにて検討することを目的とした。方法宮城県七ヶ浜町と東北大学は，共同事業「七ヶ浜健康増進プロジェクト」において，東日本大震災後の町民の健康状態や生活状況を把握するための調査を実施している。本研究では，七ヶ浜健康増進プロジェクトが大震災から約1年後に行った調査に参加し，大震災に起因する外傷およびKessler 6項目心理的苦痛尺度（以下，K6）の全設問に回答した対象者のうち，20歳以上の男女3,844人（男性1,821人/女性2,023人）を解析対象とした。心理的苦痛（K6で24点満点中13点以上を「あり」，12点以下を「なし」と定義）を目的変数，身体的外傷の有無を説明変数とし，性，年齢，社会的要因，生活習慣を調整した多変量ロジスティック回帰分析を行った。軽度身体的外傷と心理的苦痛の関連について，震災被害（近親者の喪失，人の死の目撃，家屋損壊程度）のそれぞれで層別化した解析も併せて実施した。結果身体的外傷なしの群に対し，ありの群における心理的苦痛の多変量調整済みオッズ比は2.05（1.26-3.34）と有意な正の関連を示した。また，軽度身体的外傷（「擦り傷」，「切り傷・刺し傷」，「打撲・捻挫」）なしの群に対し，ありの群における心理的苦痛の多変量調整済みオッズ比は2.18（1.32-3.59）と有意な正の関連を示した。家屋損壊程度に基づく層別化解析において，家屋が半壊以下であった群では4.01（2.03-7.93）と有意な関連を示したが，大規模半壊以上の群では両者の関連は有意でなく，家屋損壊程度と軽度身体的外傷の間に有意な交互作用が示された（P for interaction=0.03）。結論東日本大震災の甚大な被害を受けた地域住民約4,000人を対象に，大震災に起因する身体的外傷と心理的苦痛の関連を検討した。その結果，大震災に起因する軽度身体的外傷と心理的苦痛の間に有意な正の関連が認められた。心理的苦痛のハイリスク者を同定する上で，軽度身体外傷を有する者についても考慮する必要がある。
Associations between Socioeconomic Status and the Prevalence and Treatment of Hypercholesterolemia in a General Japanese Population: NIPPON DATA2010. 査読有り

Fujiyoshi N, Arima H, Satoh A, Ojima T, Nishi N, Okuda N, Kadota A, Ohkubo T, Hozawa A, Nakaya N, Fujiyoshi A, Okamura T, Ueshima H, Okayama A, Miura K, NIPPON DATA, Research Group

Journal of atherosclerosis and thrombosis　25　(7)　606-620　2018年1月

DOI： 10.5551/jat.42531 　

ISSN：1340-3478
Long-term oncological outcomes of submucosal manipulation during non-curative endoscopic submucosal dissection for submucosal invasive gastric cancer: a multicenter retrospective study in Japan 査読有り

Hirotaka Ito, Takuji Gotoda, Tsuneo Oyama, Noboru Kawata, Akiko Takahashi, Yoshikazu Yoshifuku, Shu Hoteya, Masahiro Nakagawa, Waku Hatta, Masaaki Hirano, Mitsuru Esaki, Mitsuru Matsuda, Ken Ohnita, Ryo Shimoda, Motoyuki Yoshida, Osamu Dohi, Jun Takada, Keiko Tanaka, Shinya Yamada, Tsuyotoshi Tsuji, Yoshiaki Hayashi, Naoki Nakaya, Tomohiro Nakamura, Tooru Shimosegawa

Surgical Endoscopy and Other Interventional Techniques　32　(1)　196-203　2018年1月1日
出版者・発行元： Springer New York LLC
DOI： 10.1007/s00464-017-5659-x 　

ISSN：1432-2218 0930-2794
Cancer screening participation in schizophrenic outpatients and the influence of their functional disability on the screening rate: A cross-sectional study in Japan 査読有り

Masaki Fujiwara, Masatoshi Inagaki, Naoki Nakaya, Maiko Fujimori, Yuji Higuchi, Chinatsu Hayashibara, Ryuhei So, Kyoko Kakeda, Masafumi Kodama, Yosuke Uchitomi, Norihito Yamada

PSYCHIATRY AND CLINICAL NEUROSCIENCES　71　(12)　813-825　2017年12月

DOI： 10.1111/pcn.12554 　

ISSN：1323-1316

eISSN：1440-1819
Population-based biobank participants' preferences for receiving genetic test results 査読有り

Kayono Yamamoto, Tsuyoshi Hachiya, Akimune Fukushima, Naoki Nakaya, Akira Okayama, Kozo Tanno, Fumie Aizawa, Tomoharu Tokutomi, Atsushi Hozawa, Atsushi Shimizu

JOURNAL OF HUMAN GENETICS　62　(12)　1037-1048　2017年12月

DOI： 10.1038/jhg.2017.81 　

ISSN：1434-5161

eISSN：1435-232X
Psychological Distress among Individuals Whose Partners Have Cancer 査読有り

Naoki Nakaya, Toshimasa Sone, Kumi Nakaya, Yasutake Tomata, Atsushi Hozawa, Ichiro Tsuji

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　243　(1)　27-33　2017年9月

DOI： 10.1620/tjem.243.27 　

ISSN：0040-8727

eISSN：1349-3329
Psychological distress in men with prostate cancer and their partners before and after cancer diagnosis: a longitudinal study 査読有り

Akira Oba, Naoki Nakaya, Kumi Saito-Nakaya, Masaru Hasumi, Hiroyuki Takechi, Seiji Arai, Nobuaki Shimizu

JAPANESE JOURNAL OF CLINICAL ONCOLOGY　47　(8)　735-742　2017年8月

DOI： 10.1093/jjco/hyx066 　

ISSN：0368-2811

eISSN：1465-3621
Coffee Consumption and Mortality Due to All Causes, Cardiovascular Disease, and Cancer in Japanese Women 査読有り

Kemmyo Sugiyama, Shinichi Kuriyama, Munira Akhter, Masako Kakizaki, Naoki Nakaya, Kaori Ohmori-Matsuda, Taichi Shimazu, Masato Nagai, Yumi Sugawara, Atsushi Hozawa, Akira Fukao, Ichiro Tsuji

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY　313　(1)　1007-1013　2017年7月

DOI： 10.3945/jn.109.109314 　

ISSN：1040-0605

eISSN：1522-1504
Development of a Questionnaire Method of Screening for Citrin Deficiency in Schoolchildren 査読有り

Miyashita M, Ishikuro M, Kikuya M, Yamanaka C, Mizuno S, Nagai M, Sato Y, Obara T, Metoki H, Kikuchi A, Nakaya N, Hozawa A, Tsuji I, Yaegashi N, Yamamoto M, Kure S, Kuriyama S

Journal of Pediatrics and Congenital Disorders　4　101　2017年7月
精神科病院に通院中の統合失調症患者におけるがん検診受診率アンケートによる単施設横断研究査読有り

藤原雅樹, 稲垣正俊, 中谷直樹, 樋口裕二, 藤森麻衣子, 林原千夏, 宋龍平, 掛田恭子, 児玉匡史, 内富庸介, 山田了士

精神神経学雑誌　(2017特別号)　S291-S291　2017年6月
出版者・発行元： (公社)日本精神神経学会
ISSN：0033-2658
A Scoring System to Stratify Curability after Endoscopic Submucosal Dissection for Early Gastric Cancer: "eCura system" 査読有り

Waku Hatta, Takuji Gotoda, Tsuneo Oyama, Noboru Kawata, Akiko Takahashi, Yoshikazu Yoshifuku, Shu Hoteya, Masahiro Nakagawa, Masaaki Hirano, Mitsuru Esaki, Mitsuru Matsuda, Ken Ohnita, Kohei Yamanouchi, Motoyuki Yoshida, Osamu Dohi, Jun Takada, Keiko Tanaka, Shinya Yamada, Tsuyotoshi Tsuji, Hirotaka Ito, Yoshiaki Hayashi, Naoki Nakaya, Tomohiro Nakamura, Tooru Shimosegawa

AMERICAN JOURNAL OF GASTROENTEROLOGY　112　(6)　874-881　2017年6月

DOI： 10.1038/ajg.2017.95 　

ISSN：0002-9270

eISSN：1572-0241
Psychological Distress and the Risk of Withdrawing From Hypertension Treatment After an Earthquake Disaster 査読有り

Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS　11　(2)　179-182　2017年4月

DOI： 10.1017/dmp.2016.102 　

ISSN：1935-7893

eISSN：1938-744X
The Association Between the History of Hypertensive Disorders of Pregnancy, Obesity and Hypertension in Later Life by Age Group: A Cross-Sectional Analysis. 査読有り

Maiko Wagata, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Hirohito Metoki, Akimune Fukushima, Nobuo Yaegashi, Shigeo Kure, Shinichi Kuriyama, Atsushi Hozawa, Junichi Sugawara

REPRODUCTIVE SCIENCES　24　63A-63A　2017年3月

ISSN：1933-7191

eISSN：1933-7205
Age at first birth and long-term mortality for mothers: the Ohsaki cohort study 査読有り

Taichi Sakai, Yumi Sugawara, Ikue Watanabe, Takashi Watanabe, Yasutake Tomata, Naoki Nakaya, Ichiro Tsuji

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE　22　(1)　24　2017年

DOI： 10.1186/s12199-017-0631-x 　

ISSN：1342-078X

eISSN：1347-4715
The Risk Factors for Metastasis in Non-Ampullary Duodenal Neuroendocrine Tumors Measuring 20 mm or Less in Diameter 査読有り

Waku Hatta, Tomoyuki Koike, Katsunori Iijima, Kiyotaka Asanuma, Naoki Asano, Hiroaki Musha, Yoshifumi Inomata, Toshikazu Sano, Hiroyuki Endo, Atsushi Ikehata, Toru Horii, Motoki Ohyauchi, Satoshi Yokosawa, Atsuko Kasajima, Fumiyoshi Fujishima, Hironobu Sasano, Naoki Nakaya, Tomohiro Nakamura, Tooru Shimosegawa

DIGESTION　95　(3)　201-209　2017年

DOI： 10.1159/000459619 　

ISSN：0012-2823

eISSN：1421-9867
Impact of social capital on psychological distress and interaction with house destruction and displacement after the Great East Japan Earthquake of 2011 査読有り

Naho Tsuchiya, Naoki Nakaya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Jun Aida, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

PSYCHIATRY AND CLINICAL NEUROSCIENCES　71　(1)　52-60　2017年1月

DOI： 10.1111/pcn.12467 　

ISSN：1323-1316

eISSN：1440-1819
The synchronized trial on expectant mothers with depressive symptoms by omega-3 PUFAs (SYNCHRO): Study protocol for a randomized controlled trial 査読有り

Daisuke Nishi, Kuan-Pin Su, Kentaro Usuda, Yi-Ju Jill Chiang, Tai-Wei Guu, Kei Hamazaki, Naoki Nakaya, Toshimasa Sone, Yo Sano, Yoshiyuki Tachibana, Hiroe Ito, Keiich Isaka, Kenji Hashimoto, Tomohito Hamazaki, Yutaka J. Matsuoka

BMC PSYCHIATRY　16　(1)　321　2016年9月

DOI： 10.1186/s12888-016-1031-2 　

ISSN：1471-244X
The Tohoku Medical Megabank Project: Design and Mission 査読有り

Shinichi Kuriyama, Nobuo Yaegashi, Fuji Nagami, Tomohiko Arai, Yoshio Kawaguchi, Noriko Osumi, Masaki Sakaida, Yoichi Suzuki, Keiko Nakayama, Hiroaki Hashizume, Gen Tamiya, Hiroshi Kawame, Kichiya Suzuki, Atsushi Hozawa, Naoki Nakaya, Masahiro Kikuya, Hirohito Metoki, Ichiro Tsuji, Nobuo Fuse, Hideyasu Kiyomoto, Junichi Sugawara, Akito Tsuboi, Shinichi Egawa, Kiyoshi Ito, Koichi Chida, Tadashi Ishii, Hiroaki Tomita, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Seizo Koshiba, Kengo Kinoshita, Soichi Ogishima, Takako Takai-Igarashi, Teiji Tominaga, Osamu Tanabe, Noriaki Ohuchi, Toru Shimosegawa, Shigeo Kure, Hiroshi Tanaka, Sadayoshi Ito, Jiro Hitomi, Kozo Tanno, Motoyuki Nakamura, Kuniaki Ogasawara, Seiichiro Kobayashi, Kiyomi Sakata, Mamoru Satoh, Atsushi Shimizu, Makoto Sasaki, Ryujin Endo, Kenji Sobue, Masayuki Yamamoto

JOURNAL OF EPIDEMIOLOGY　26　(9)　493-511　2016年9月

DOI： 10.2188/jea.JE20150268 　

ISSN：0917-5040
Does the flushing response modify the relationship between alcohol intake and hypertension in the Japanese population? NIPPON DATA2010 査読有り

Mana Kogure, Naho Tsuchiya, Atsushi Hozawa, Naoki Nakaya, Tomohiro Nakamura, Naomi Miyamatsu, Hideo Tanaka, Ichiro Wakabayashi, Aya Higashiyama, Nagako Okuda, Naoyuki Takashima, Akira Fujiyoshi, Aya Kadota, Takayoshi Ohkubo, Tomonori Okamura, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura

HYPERTENSION RESEARCH　39　(9)　670-679　2016年9月

DOI： 10.1038/hr.2016.46 　

ISSN：0916-9636

eISSN：1348-4214
Partners' Ongoing Treatment for Chronic Disease and the Risk of Psychological Distress after the Great East Japan Earthquake 査読有り

Naoki Nakaya, Akira Narita, Naho Tsuchiya, Tomohiro Nakamura, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　239　(4)　307-314　2016年8月

DOI： 10.1620/tjem.239.307 　

ISSN：0040-8727

eISSN：1349-3329
Omega-3 fatty acid supplementation for expectant mothers with depressive symptoms in Japan and Taiwan: An open-label trial 査読有り

Daisuke Nishi, Kuan-Pin Su, Kentaro Usuda, Yi-Ju Jill Chiang, Tai-Wei Guu, Kei Hamazaki, Naoki Nakaya, Toshimasa Sone, Yo Sano, Hiroe Ito, Keiichi Isaka, Kenji Hashimoto, Tomohito Hamazaki, Yutaka J. Matsuoka

PSYCHIATRY AND CLINICAL NEUROSCIENCES　70　(6)　253-254　2016年6月

DOI： 10.1111/pcn.12388 　

ISSN：1323-1316

eISSN：1440-1819
Public Attitudes toward an Epidemiological Study with Genomic Analysis in the Great East Japan Earthquake Disaster Area 査読有り

Mami Ishikuro, Naoki Nakaya, Taku Obara, Yuki Sato, Hirohito Metoki, Masahiro Kikuya, Naho Tsuchiya, Tomohiro Nakamura, Fuji Nagami, Shinichi Kuriyama, Atsushi Hozawa

PREHOSPITAL AND DISASTER MEDICINE　31　(3)　330-334　2016年6月

DOI： 10.1017/S1049023X16000182 　

ISSN：1049-023X

eISSN：1945-1938
Effect of Hydroxyhydroquinone-Reduced and Chlorogenic Acids-Rich vs Usual Coffee on Symptoms and Glucagon-like Peptide-1 in Patients with Functional Dyspepsia 査読有り

Risa Yagami, Tomotaka Shoji, Naoki Nakaya, Tomohiro Nakamura, Yuka Endo, Yasuhiro Sato, Tomomi Machida, Takatsugu Machida, Michiko Kano, Motoyori Kanazawa, Kumi Nakaya, Tomohiko Muratsubaki, Yuuichi Aizawa, Hazuki Komuro, Ayaka Sasaki, Masao Takeshita, Tomohito Mizuno, Takuya Watanabe, Shin Fukudo

GASTROENTEROLOGY　150　(4)　S352-S352　2016年4月

DOI： 10.1016/S0016-5085(16)31236-7 　

ISSN：0016-5085

eISSN：1528-0012
Long-Term Outcome and the Risk Factors for Recurrence in Patients Who Do Not Meet Current Curative Criteria of Endoscopic Submucosal Dissection for Early Gastric Cancer: A Multicenter Retrospective Study in Japan 査読有り

Waku Hatta, Takuji Gotoda, Tsuneo Oyama, Noboru Kawata, Hiroyuki Ono, Yoshikazu Yoshifuku, Akiko Takahashi, Shu Hoteya, Masahiro Nakagawa, Koki Nakamura, Masaaki Hirano, Mitsuru Esaki, Mitsuru Matsuda, Yasumasa Hara, Ken Ohnita, Ryo Shimoda, Kohei Yamanouchi, Motoyuki Yoshida, Osamu Dohi, Jun Takada, Keiko Tanaka, Shinya Yamada, Tsuyotoshi Tsuji, Hirotaka Ito, Yoshiaki Hayashi, Naoki Nakaya, Tomohiro Nakamura, Tooru Shimosegawa

GASTROENTEROLOGY　150　(4)　S868-S868　2016年4月

DOI： 10.1016/S0016-5085(16)32925-0 　

ISSN：0016-5085

eISSN：1528-0012
Prospect of future housing and risk of psychological distress at 1 year after an earthquake disaster 査読有り

Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

PSYCHIATRY AND CLINICAL NEUROSCIENCES　70　(4)　182-189　2016年4月

DOI： 10.1111/pcn.12377 　

ISSN：1323-1316

eISSN：1440-1819
Longitudinal association between time-varying social isolation and psychological distress after the Great East Japan Earthquake 査読有り

Toshimasa Sone, Naoki Nakaya, Yumi Sugawara, Yasutake Tomata, Takashi Watanabe, Ichiro Tsuji

SOCIAL SCIENCE & MEDICINE　152　96-101　2016年3月

DOI： 10.1016/j.socscimed.2016.01.037 　

ISSN：0277-9536
Unemployment risk among individuals undergoing medical treatment for chronic diseases 査読有り

N. Nakaya, T. Nakamura, N. Tsuchiya, I. Tsuji, A. Hozawa, H. Tomita

OCCUPATIONAL MEDICINE-OXFORD　66　(2)　143-149　2016年3月

DOI： 10.1093/occmed/kqv159 　

ISSN：0962-7480

eISSN：1471-8405
Eczema and Asthma Symptoms among Schoolchildren in Coastal and Inland Areas after the 2011 Great East Japan Earthquake: The ToMMo Child Health Study 査読有り

Masako Miyashita, Masahiro Kikuya, Chizuru Yamanaka, Mami Ishikuro, Taku Obara, Yuki Sato, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Hideyasu Kiyomoto, Junichi Sugawara, Atsushi Hozawa, Nobuo Fuse, Yoichi Suzuki, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　237　(4)　297-305　2015年12月

DOI： 10.1620/tjem.237.297 　

ISSN：0040-8727

eISSN：1349-3329
Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals 査読有り

Masao Nagasaki, Jun Yasuda, Fumiki Katsuoka, Naoki Nariai, Kaname Kojima, Yosuke Kawai, Yumi Yamaguchi-Kabata, Junji Yokozawa, Inaho Danjoh, Sakae Saito, Yukuto Sato, Takahiro Mimori, Kaoru Tsuda, Rumiko Saito, Xiaoqing Pan, Satoshi Nishikawa, Shin Ito, Yoko Kuroki, Osamu Tanabe, Nobuo Fuse, Shinichi Kuriyama, Hideyasu Kiyomoto, Atsushi Hozawa, Naoko Minegishi, James Douglas Engel, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto

NATURE COMMUNICATIONS　6　8018　2015年8月

DOI： 10.1038/ncomms9018 　

ISSN：2041-1723
The Association Between Medical Treatment of Physical Diseases and Psychological Distress After the Great East Japan Earthquake: The Shichigahama Health Promotion Project 査読有り

Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS　9　(4)　374-381　2015年8月

DOI： 10.1017/dmp.2015.52 　

ISSN：1935-7893

eISSN：1938-744X
Time series analysis of gastric acid secretion over a 20-year period in normal Japanese men 査読有り

Katsunori Iijima, Tomoyuki Koike, Yasuhiko Abe, Shuichi Ohara, Naoki Nakaya, Tooru Shimosegawa

JOURNAL OF GASTROENTEROLOGY　50　(8)　853-861　2015年8月

DOI： 10.1007/s00535-014-1031-2 　

ISSN：0944-1174

eISSN：1435-5922
Maladjustment to Academic Life and Employment Anxiety in University Students with Irritable Bowel Syndrome 査読有り

Jun Tayama, Naoki Nakaya, Toyohiro Hamaguchi, Tatsuo Saigo, Atsushi Takeoka, Toshimasa Sone, Shin Fukudo, Susumu Shirabe

PLOS ONE　10　(6)　e0129345　2015年6月

DOI： 10.1371/journal.pone.0129345 　

ISSN：1932-6203
Protocol and Research Perspectives of the ToMMo Child Health Study after the 2011 Great East Japan Earthquake 査読有り

Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, Yuki Sato, Taku Obara, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Hideyasu Kiyomoto, Junichi Sugawara, Atsushi Hozawa, Nobuo Fuse, Yoichi Suzuki, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　236　(2)　123-130　2015年6月

DOI： 10.1620/tjem.236.123 　

ISSN：0040-8727

eISSN：1349-3329
Personality traits and coping styles explain anxiety in lung cancer patients to a greater extent than other factors 査読有り

Ken Shimizu, Naoki Nakaya, Kumi Saito-Nakaya, Tatsuo Akechi, Asao Ogawa, Daisuke Fujisawa, Toshimasa Sone, Kazuhiro Yoshiuchi, Koichi Goto, Motoki Iwasaki, Shoichiro Tsugane, Yosuke Uchitomi

JAPANESE JOURNAL OF CLINICAL ONCOLOGY　45　(5)　456-463　2015年5月

DOI： 10.1093/jjco/hyv024 　

ISSN：0368-2811

eISSN：1465-3621
Personality and breast cancer risk and survival: the Miyagi Cohort Study 査読有り

Yuko Minami, Toru Hosokawa, Naoki Nakaya, Yumi Sugawara, Yoshikazu Nishino, Yoichiro Kakugawa, Akira Fukao, Ichiro Tsuji

BREAST CANCER RESEARCH AND TREATMENT　150　(3)　675-684　2015年4月

DOI： 10.1007/s10549-015-3364-9 　

ISSN：0167-6806

eISSN：1573-7217
Prediction of Upper Limb Recovery in the Acute Phase of Cerebrovascular Disease: Evaluation of "Functional Hand'' Using the Manual Function Test 査読有り

Toshimasa Sone, Naoki Nakaya, Kazuaki Iokawa, Keiichi Hasegawa, Tetsu Tsukada, Mariko Kaneda, Toyohiro Hamaguchi, Kenji Suzuki

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　24　(4)　815-822　2015年4月

DOI： 10.1016/j.jstrokecerebrovasdis.2014.11.018 　

ISSN：1052-3057

eISSN：1532-8511
Personality and suicide risk: the impact of economic crisis in Japan 査読有り

F. Tanji, M. Kakizaki, Y. Sugawara, I. Watanabe, N. Nakaya, Y. Minami, A. Fukao, I. Tsuji

PSYCHOLOGICAL MEDICINE　45　(3)　559-573　2015年2月

DOI： 10.1017/S0033291714001688 　

ISSN：0033-2917

eISSN：1469-8978
iJGVD: an integrative Japanese genome variation database based on whole-genome sequencing. 国際誌査読有り

Yamaguchi-Kabata Y, Nariai N, Kawai Y, Sato Y, Kojima K, Tateno M, Katsuoka F, Yasuda J, Yamamoto M, Nagasaki M

Human genome variation　2　15050-15050　2015年

DOI： 10.1038/hgv.2015.50 　
Prediction of upper limb recovery in the acute phase of cerebrovascular disease. 査読有り

Sone T, Nakaya N, Iokawa K, Hasegawa K, Tsukada T, Kaneda M, Hamaguchi T

Nihon eiseigaku zasshi. Japanese journal of hygiene　70　62-68　2015年
出版者・発行元： 1
DOI： 10.1265/jjh.70.62 　

ISSN：0021-5082
Validation of multiple single nucleotide variation calls by additional exome analysis with a semiconductor sequencer to supplement data of whole-genome sequencing of a human population 査読有り

Ikuko N Motoike, Mitsuyo Matsumoto, Inaho Danjoh, Fumiki Katsuoka, Kaname Kojima, Naoki Nariai, Yukuto Sato, Yumi Yamaguchi-Kabata, Shin Ito, Hisaaki Kudo, Ichiko Nishijima, Satoshi Nishikawa, Xiaoqing Pan, Rumiko Saito, Sakae Saito, Tomo Saito, Matsuyuki Shirota, Kaoru Tsuda, Junji Yokozawa, Kazuhiko Igarashi, Naoko Minegishi, Osamu Tanabe, Nobuo Fuse, Masao Nagasaki, Kengo Kinoshita, Jun Yasuda, Masayuki Yamamoto

BMC Genomics　15　(1)　2014年12月
出版者・発行元： Springer Science and Business Media LLC
DOI： 10.1186/1471-2164-15-673 　

eISSN：1471-2164
Identification of acquired mutations by whole-genome sequencing in GATA-2 deficiency evolving into myelodysplasia and acute leukemia. 国際誌

Tohru Fujiwara, Noriko Fukuhara, Ryo Funayama, Naoki Nariai, Mayumi Kamata, Takeshi Nagashima, Kaname Kojima, Yasushi Onishi, Yoji Sasahara, Kenichi Ishizawa, Masao Nagasaki, Keiko Nakayama, Hideo Harigae

Annals of hematology　93　(9)　1515-22　2014年9月

DOI： 10.1007/s00277-014-2090-4 　

詳細を見る詳細を閉じる

Heterozygous GATA-2 germline mutations are associated with overlapping clinical manifestations termed GATA-2 deficiency, characterized by immunodeficiency and predisposition to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). However, there is considerable clinical heterogeneity among patients, and the molecular basis for the evolution of immunodeficiency into MDS/AML remains unknown. Thus, we conducted whole-genome sequencing on a patient with a germline GATA-2 heterozygous mutation (c. 988 C > T; p. R330X), who had a history suggestive of immunodeficiency and evolved into MDS/AML. Analysis was conducted with DNA samples from leukocytes for immunodeficiency, bone marrow mononuclear cells for MDS and bone marrow-derived mesenchymal stem cells. Whereas we did not identify a candidate genomic deletion that may contribute to the evolution into MDS, a total of 280 MDS-specific nonsynonymous single nucleotide variants were identified. By narrowing down with the single nucleotide polymorphism database, the functional missense database, and NCBI information, we finally identified three candidate mutations for EZH2, HECW2 and GATA-1, which may contribute to the evolution of the disease.
Psychosocial Longitudinal Study Profile and Distress of Couples in Relation to the Conduct of Prostate Biopsy 査読有り

Akira Oba, Naoki Nakaya, Masaru Hasumi, Kumiko Ono-Yanaba, Kumi Saito-Nakaya, Hiroyuki Takechi, Seiji Arai, Nobuaki Shimizu

JAPANESE JOURNAL OF CLINICAL ONCOLOGY　44　(5)　463-471　2014年5月

DOI： 10.1093/jjco/hyu022 　

ISSN：0368-2811

eISSN：1465-3621
Gastrointestinal specific anxiety in irritable bowel syndrome: Validation of the Japanese version of the visceral sensitivity index for university students 査読有り

Tatsuo Saigo, Jun Tayama, Toyohiro Hamaguchi, Naoki Nakaya, Tadaaki Tomiie, Peter J. Bernick, Motoyori Kanazawa, Jennifer S. Labus, Bruce D. Naliboff, Susumu Shirabe, Shin Fukudo

BioPsychoSocial Medicine　8　(1)　10　2014年3月21日
出版者・発行元： 1
DOI： 10.1186/1751-0759-8-10 　

eISSN：1751-0759
The association between self-reported history of physical diseases and psychological distress in a community-dwelling Japanese population: the Ohsaki Cohort 2006 Study 査読有り

Naoki Nakaya, Mana Kogure, Kumi Saito-Nakaya, Yasutake Tomata, Toshimasa Sone, Masako Kakizaki, Ichiro Tsuji

EUROPEAN JOURNAL OF PUBLIC HEALTH　24　(1)　45-49　2014年2月

DOI： 10.1093/eurpub/ckt017 　

ISSN：1101-1262

eISSN：1464-360X
QOL向上のための,主に精神,心理,社会,スピリチュアルな側面からの患者・家族支援プログラムに関する研究がんリハビリテーションプログラムの開発

岡村仁, 安部能成, 阿部靖, 梅澤志乃, 大庭章, 木村浩彰, 栗原美穂, 酒井太一, 佐藤大介, 鈴木牧子, 曽根稔雅, 中谷直樹, 永田友美, 並木あかね, 濱口豊太, 村松直子, 吉原広和, 余宮きのみ

QOL向上のための、主に精神、心理、社会、スピリチュアルな側面からの患者・家族支援プログラムに関する研究平成25年度総括・分担研究報告書　52-54　2014年
肺がん患者に合併する抑うつの危険因子大規模データベースを用いた身体・心理・社会的要因の包括的検討

清水研, 中谷直樹, 中谷久美, 明智龍男, 山田祐, 藤森麻衣子, 小川朝生, 藤澤大介, 後藤功一, 津金昌一郎, 岩崎基, 内富庸介

総合病院精神医学　26　(1)　58-68　2014年1月
出版者・発行元： (一社)日本総合病院精神医学会
ISSN：0915-5872
Effect of Psychosocial Factors on Cancer Risk and Survival 査読有り

Naoki Nakaya

JOURNAL OF EPIDEMIOLOGY　24　(1)　1-6　2014年1月

DOI： 10.2188/jea.JE20130124 　

ISSN：0917-5040

eISSN：1349-9092
Relationship Between Serum Isoflavone Levels and Disability-Free Survival Among Community-Dwelling Elderly Individuals: Nested Case-Control Study of the Tsurugaya Project 査読有り

Atsushi Hozawa, Yumi Sugawara, Yasutake Tomata, Masako Kakizaki, Toru Tsuboya, Kaori Ohmori-Matsuda, Naoki Nakaya, Shinichi Kuriyama, Akira Fukao, Ichiro Tsuji

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES　68　(4)　465-472　2013年4月

DOI： 10.1093/gerona/gls198 　

ISSN：1079-5006
Long sleep duration and cause-specific mortality according to physical function and self-rated health: the Ohsaki Cohort Study 査読有り

Masako Kakizaki, Shinichi Kuriyama, Naoki Nakaya, Toshimasa Sone, Masato Nagai, Yumi Sugawara, Atsushi Hozawa, Shin Fukudo, Ichiro Tsuji

JOURNAL OF SLEEP RESEARCH　22　(2)　209-216　2013年4月

DOI： 10.1111/j.1365-2869.2012.01053.x 　

ISSN：0962-1105
Systematic review of rehabilitation intervention in palliative care for cancer patients. 査読有り

Abe K, Nakaya N, Sone T, Hamaguchi T, Sakai T, Sato D, Okamura H

J Palliat Care Med　2　(131)　2013年2月
QOL向上のための,主に精神,心理,社会,スピリチュアルな側面からの患者・家族支援プログラムに関する研究がんリハビリテーションプログラムの開発

岡村仁, 安部能成, 阿部靖, 梅澤志乃, 大庭章, 木村浩彰, 栗原美穂, 酒井太一, 佐藤大介, 鈴木牧子, 曽根稔雅, 中谷直樹, 永田友美, 並木あかね, 濱口豊太, 村松直子, 吉原広和, 余宮きのみ

QOL向上のための、主に精神、心理、社会、スピリチュアルな側面からの患者・家族支援プログラムに関する研究平成24年度総括・分担研究報告書　49-52　2013年
介護予防サービス利用者における生活機能の予後予測及び効果的な運動器の機能向上プログラムの実施内容に対する評価査読有り

曽根稔雅, 中谷直樹, 遠又靖丈, 相田潤, 大久保一郎, 大原里子, 大渕修一, 杉山みち子, 安村誠司, 鈴木隆雄, 辻一郎

日本衛生学雑誌　68　(1)　11-21　2013年1月
Prognostic Prediction of the Functional Capacity and Effectiveness of Functional Improvement Program of the Musculoskeletal System among Users of Preventive Care Service under Long-Term Care Insurance. 査読有り

中谷直樹

Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene).　68(1)　(1)　11-21　2013年
出版者・発行元： 1
DOI： 10.1265/jjh.68.11 　

ISSN：0021-5082 1882-6482

eISSN：1882-6482

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OBJECTIVE: The purpose of this study was to examine the effectiveness of the Functional Improvement Program of the Musculoskeletal System among users of Preventive Care Service under Long-Term Care Insurance. METHODS: A total of 3,073 subjects were analyzed. We used the prediction formula to estimate the predicted value of the Kihon Checklist after one year, and calculated the measured value minus the predicted value. The subjects were divided into two groups according to the measured value minus predicted value tertiles: the lowest and middle tertile (good-to-fair measured value) and the highest tertile (poor measured value). We used a multiple logistic regression model to calculate the odds ratio (OR) and 95% confidence interval (CI) of the good-to-fair measured values of the Kihon Checklist after one year, according to the Functional Improvement Program of the Musculoskeletal System. RESULTS: In potentially dependent elderly, the multivariate adjusted ORs (95% CI) of the good-to-fair measured values were 2.4 (1.3-4.4) for those who attended the program eight times or more in a month (vs those who attended it three times or less in a month), 1.3 (1.0-1.8) for those who engaged in strength training using machines (vs those who did not train), and 1.4 (1.0-1.9) for those who engaged in endurance training. CONCLUSIONS: In this study, among potentially dependent elderly, those who attended the program eight times or more in a month and those who engaged in strength training using machines or endurance training showed a significant improvement of their functional capacity.
All-Cause Mortality Among Men Whose Cohabiting Partner Has Been Diagnosed with Cancer 査読有り

Naoki Nakaya, Kumi Saito-Nakaya, Pernille E. Bidstrup, Susanne O. Dalton, Kirsten Frederiksen, Hanne Wurtzen, Marianne Steding-Jessen, Yosuke Uchitomi, Morten Frisch, Christoffer Johansen

EPIDEMIOLOGY　24　(1)　96-99　2013年1月

DOI： 10.1097/EDE.0b013e318276cced 　

ISSN：1044-3983
Effects of personality traits on the manifestations of irritable bowel syndrome. 国際誌査読有り

Jun Tayama, Naoki Nakaya, Toyohiro Hamaguchi, Tadaaki Tomiie, Masae Shinozaki, Tatsuo Saigo, Susumu Shirabe, Shin Fukudo

BioPsychoSocial medicine　6　(1)　20-20　2012年10月30日
出版者・発行元： 1
DOI： 10.1186/1751-0759-6-20 　

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OBJECTIVE: Previous studies have reported that patients with irritable bowel syndrome (IBS) show high neuroticism. However, the precise association between the IBS subtypes and the degree of neuroticism in younger populations is largely unknown. We tested our hypothesis that subjects with diarrhea-predominant IBS may have a higher degree of neuroticism than subjects without IBS or those with other subtypes of IBS. We also verified the additional hypothesis that the severity of neuroticism might be correlated with the severity of IBS in younger populations. METHODS: We conducted a cross-sectional survey of 557 university students, ranging in age from 18 to 21 years. Presence/ absence of IBS and determination of the IBS subtype was by the Rome II Modular Questionnaire, while the severity of IBS was determined by the IBS severity index (IBS-SI). The degree of neuroticism was evaluated using the Maudsely Personality Inventory (MPI). The presence/absence of psychological distress was measured with the K6 scale. RESULTS: Neuroticism scores in the subjects with diarrhea-predominant IBS were significantly higher than those in the non-IBS subjects or subjects with constipation-predominant IBS. The neuroticism scores were significantly correlated with the IBS-SI scores in all subjects with IBS. CONCLUSION: These results suggest that neuroticism is involved in the pathophysiology of IBS in young subjects, especially in that of the diarrhea-predominant subtype.
Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells 査読有り

Hideto Koso, Haruna Takeda, Christopher Chin Kuan Yew, Jerrold M. Ward, Naoki Nariai, Kazuko Ueno, Masao Nagasaki, Sumiko Watanabe, Alistair G. Rust, David J. Adams, Neal G. Copeland, Nancy A. Jenkins

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　109　(44)　E2998-E3007　2012年10月

DOI： 10.1073/pnas.1215899109 　

ISSN：0027-8424
PERITRAUMATIC DISTRESS, WATCHING TELEVISION AND POSTTRAUMATIC STRESS SYMPTOMS AMONG RESCUE WORKERS AFTER THE GREAT EAST JAPAN EARTHQUAKE 査読有り

Y. Matsuoka, D. Nishi, N. Nakaya, T. Sone, H. Noguchi, K. Hamazaki, T. Hamazaki, Y. Koido

INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE　19　S249-S249　2012年9月

DOI： 10.1371/journal.pone.0035248 　

ISSN：1070-5503

eISSN：1532-7558
Clinical biopsychosocial risk factors for depression in lung cancer patients: a comprehensive analysis using data from the Lung Cancer Database Project 査読有り

K. Shimizu, N. Nakaya, K. Saito-Nakaya, T. Akechi, Y. Yamada, M. Fujimori, A. Ogawa, D. Fujisawa, K. Goto, M. Iwasaki, S. Tsugane, Y. Uchitomi

ANNALS OF ONCOLOGY　23　(8)　1973-1979　2012年8月

DOI： 10.1093/annonc/mds061 　

ISSN：0923-7534
The predictive power of physical function assessed by questionnaire and physical performance measures for subsequent disability 査読有り

Masayuki Hoshi, Atsushi Hozawa, Shinichi Kuriyama, Naoki Nakaya, Kaori Ohmori-Matsuda, Toshimasa Sone, Masako Kakizaki, Kaijun Niu, Kazuki Fujita, Shouzoh Ueki, Hiroshi Haga, Ryoichi Nagatomi, Ichiro Tsuji

Aging Clinical and Experimental Research　24　(4)　345-353　2012年8月

DOI： 10.3275/8104 　

ISSN：1594-0667 1720-8319

eISSN：1720-8319
[Activities in daily life and changes in care level among users of Preventive Care Service under Long-Term Care Insurance]. 査読有り

Toshimasa Sone, Naoki Nakaya, Yasutake Tomata, Jun Aida, Ichiro Okubo, Satoko Ohara, Shuichi Obuchi, Michiko Sugiyama, Seiji Yasumura, Takao Suzuki, Ichiro Tsuji

Nihon eiseigaku zasshi. Japanese journal of hygiene　67　(3)　401-7　2012年5月
出版者・発行元： 3
DOI： 10.1265/jjh.67.401 　

ISSN：0021-5082

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OBJECTIVES: The aim of this study was to investigate the association between social roles (engaged in working outside or house work) or hobbies and changes in care level among users of Preventive Care Service under Long-Term Care Insurance. METHODS: A total of 8,734 Preventive Care Service users were analyzed. The assessment was conducted between February 2007 and December 2008. The improvement, maintenance, and aggravation in care level were defined by changes in care level from the beginning to the end. To assess their activities in daily life, the participants were asked, "Which is the major activity in your daily life? Please select one from the following: working outside, house work, hobbies, watching television, others, or none." We used the multiple logistic regression model to calculate the odds ratio (OR) and 95% confidence interval (CI) of the maintenance or improvement in care level according to the category of activity. RESULTS: As compared with subjects who answered none, the multivariate adjusted ORs (95% CI) of the maintenance or improvement in care level were 2.0 (1.4-2.9) for those who answered working outside, 1.5 (1.2-1.8) for those who answered house work, and 1.5 (1.2-1.9) for those who answered hobbies. However, those who answered watching television or others did not show a significant association with the maintenance or improvement in care level. CONCLUSIONS: In this study, compared with subjects who answered none, those who answered that they were engaged in working outside, house work, or hobbies were associated with having significantly higher ORs of the maintenance or improvement in care level.
Relationship Between Serum Adiponectin Levels and Disability-Free Survival Among Community-Dwelling Elderly Individuals: The Tsurugaya Project 査読有り

Atsushi Hozawa, Yumi Sugawara, Yasutake Tomata, Masako Kakizaki, Toru Tsuboya, Kaori Ohmori-Matsuda, Naoki Nakaya, Shinichi Kuriyama, Akira Fukao, Ichiro Tsuji

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES　67　(5)　530-536　2012年5月

DOI： 10.1093/gerona/glr191 　

ISSN：1079-5006
C-reactive protein (CRP) is a predictor of high medical-care expenditures in a community-based elderly population aged 70 years and over: The Tsurugaya project 査読有り

Kaijun Niu, Atsushi Hozawa, Hui Guo, Kaori Ohmori-Matsuda, Yufei Cui, Satoru Ebihara, Naoki Nakaya, Shinichi Kuriyama, Toru Tsuboya, Masako Kakizaki, Takashi Ohrui, Hiroyuki Arai, Ichiro Tsuji, Ryoichi Nagatomi

ARCHIVES OF GERONTOLOGY AND GERIATRICS　54　(3)　E392-E397　2012年5月

DOI： 10.1016/j.archger.2012.01.014 　

ISSN：0167-4943
Peritraumatic Distress, Watching Television, and Posttraumatic Stress Symptoms among Rescue Workers after the Great East Japan Earthquake 査読有り

Daisuke Nishi, Yuichi Koido, Naoki Nakaya, Toshimasa Sone, Hiroko Noguchi, Kei Hamazaki, Tomohito Hamazaki, Yutaka Matsuoka

PLOS ONE　7　(4)　2012年4月

DOI： 10.1371/journal.pone.0035248 　

ISSN：1932-6203
EFFECT OF BASELINE SELF-EFFICACY ON PHYSICAL ACTIVITY AND PSYCHOLOGICAL STRESS AFTER A ONE-WEEK PEDOMETER INTERVENTION 査読有り

Jun Tayama, Hironori Yamasaki, Mami Tamai, Masaki Hayashida, Susumu Shirabe, Kazuki Nishiura, Toyohiro Hamaguchi, Tadaaki Tomiie, Naoki Nakaya

PERCEPTUAL AND MOTOR SKILLS　114　(2)　407-418　2012年4月

DOI： 10.2466/24.27.PMS.114.2.407-418 　

ISSN：0031-5125

eISSN：1558-688X
Stress and survival after cancer: A prospective study of a Finnish population-based cohort 査読有り

Kumi Saito-Nakaya, Pernille E. Bidstrup, Naoki Nakaya, Kirsten Frederiksen, Susanne O. Dalton, Yosuke Uchitomi, Pia Verkasalo, Markku Koskenvuo, Eero Pukkala, Jaakko Kaprio, Christoffer Johansen

CANCER EPIDEMIOLOGY　36　(2)　230-235　2012年4月

DOI： 10.1016/j.canep.2011.04.008 　

ISSN：1877-7821
Concern over radiation exposure and psychological distress among rescue workers following the Great East Japan Earthquake 査読有り

Yutaka Matsuoka, Daisuke Nishi, Naoki Nakaya, Toshimasa Sone, Hiroko Noguchi, Kei Hamazaki, Tomohito Hamazaki, Yuichi Koido

BMC PUBLIC HEALTH　12　249　2012年3月

DOI： 10.1186/1471-2458-12-249 　

ISSN：1471-2458
Green tea consumption and the risk of incident functional disability in elderly Japanese: the Ohsaki Cohort 2006 Study 査読有り

Yasutake Tomata, Masako Kakizaki, Naoki Nakaya, Toru Tsuboya, Toshimasa Sone, Shinichi Kuriyama, Atsushi Hozawa, Ichiro Tsuji

AMERICAN JOURNAL OF CLINICAL NUTRITION　95　(3)　732-739　2012年3月

DOI： 10.3945/ajcn.111.023200 　

ISSN：0002-9165
QOL向上のための,主に精神,心理,社会,スピリチュアルな側面からの患者・家族支援プログラムに関する研究がんリハビリテーションプログラムの開発

岡村仁, 安部能成, 阿部靖, 梅澤志乃, 大庭章, 木村浩彰, 栗原美穂, 酒井太一, 佐藤大介, 鈴木牧子, 曽根稔雅, 豊田瑶子, 中谷直樹, 永田友美, 並木あかね, 長谷川真紀, 濱口豊太, 村松直子, 吉原広和, 余宮きのみ

QOL向上のための、主に精神、心理、社会、スピリチュアルな側面からの患者・家族支援プログラムに関する研究平成23年度総括・分担研究報告書　45-48　2012年
介護予防サービス利用者における日常生活の過ごし方と要介護認定等の推移との関連査読有り

曽根稔雅, 中谷直樹, 遠又靖丈, 相田潤, 大久保一郎, 大原里子, 大渕修一, 杉山みち子, 安村誠司, 鈴木隆雄, 辻一郎

日本衛生学雑誌　67　(3)　401-407　2012年
Fish Oil for Attenuating Posttraumatic Stress Symptoms among Rescue Workers after the Great East Japan Earthquake: A Randomized Controlled Trial 査読有り

Daisuke Nishi, Yuichi Koido, Naoki Nakaya, Toshimasa Sone, Hiroko Noguchi, Kei Hamazaki, Tomohito Hamazaki, Yutaka Matsuoka

PSYCHOTHERAPY AND PSYCHOSOMATICS　81　(5)　315-317　2012年

DOI： 10.1159/000336811 　

ISSN：0033-3190
Impact of blunted perception of dyspnea on medical care use and expenditure, and mortality in elderly people 査読有り

Satoru Ebihara, Kaijun Niu, Takae Ebihara, Shinichi Kuriyama, Atsushi Hozawa, Kaori Ohmori-Matsuda, Naoki Nakaya, Ryoichi Nagatomi, Hiroyuki Arai, Masahiro Kohzuki, Ichiro Tsuji

FRONTIERS IN PHYSIOLOGY　3　238　2012年

DOI： 10.3389/fphys.2012.00238 　

ISSN：1664-042X
Attenuating posttraumatic distress with omega-3 polyunsaturated fatty acids among disaster medical assistance team members after the Great East Japan Earthquake: The APOP randomized controlled trial 査読有り

Yutaka Matsuoka, Daisuke Nishi, Naoki Nakaya, Toshimasa Sone, Kei Hamazaki, Tomohito Hamazaki, Yuichi Koido

BMC PSYCHIATRY　11　132　2011年8月

DOI： 10.1186/1471-244X-11-132 　

ISSN：1471-244X
Impact of physical activity and performance on medical care costs among the Japanese elderly 査読有り

Guang Yang, Kaijun Niu, Kazuki Fujita, Atsushi Hozawa, Kaori Ohmori-Matsuda, Shinichi Kuriyama, Naoki Nakaya, Satoru Ebihara, Tatsuma Okazaki, Hiu Guo, Chihaya Miura, Hideko Takahashi, Hiroyuki Arai, Ichiro Tsuji, Ryoichi Nagatomi

GERIATRICS & GERONTOLOGY INTERNATIONAL　11　(2)　157-165　2011年4月

DOI： 10.1111/j.1447-0594.2010.00651.x 　

ISSN：1444-1586
Treatment Response to Psychiatric Intervention and Predictors of Response Among Cancer Patients with Adjustment Disorders 査読有り

Ken Shimizu, Nobuya Akizuki, Naoki Nakaya, Maiko Fujimori, Daisuke Fujisawa, Asao Ogawa, Yosuke Uchitomi

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT　41　(4)　684-691　2011年4月

DOI： 10.1016/j.jpainsymman.2010.07.011 　

ISSN：0885-3924
デンマークにおける保健医療関連データベースに関する調査研究査読有り

中谷直樹, 中谷久美, 中村好一

公衆衛生 = The journal of public health practice / 『公衆衛生』編集委員会編　75　(2)　160-163　2011年2月15日
出版者・発行元：東京 : 医学書院
DOI： 10.11477/mf.1401102038 　

ISSN：0368-5187

eISSN：1882-1170
QOL向上のための,主に精神,心理,社会,スピリチュアルな側面からの患者・家族支援プログラムに関する研究がんリハビリテーションプログラムの開発

岡村仁, 安部能成, 阿部靖, 梅澤志乃, 大庭章, 木村浩彰, 栗原美穂, 酒井太一, 佐藤大介, 鈴木牧子, 曽根稔雅, 豊田瑶子, 中谷直樹, 永田友美, 並木あかね, 長谷川真紀, 濱口豊太, 村松直子, 吉原広和, 余宮きのみ

QOL向上のための、主に精神、心理、社会、スピリチュアルな側面からの患者・家族支援プログラムに関する研究平成22年度総括・分担研究報告書　34-37　2011年
Randomized controlled trial for an effect of catechin-enriched green tea consumption on adiponectin and cardiovascular disease risk factors 査読有り

Toshimasa Sone, Shinichi Kuriyama, Naoki Nakaya, Atsushi Hozawa, Taichi Shimazu, Kozue Nomura, Shouzo Rikimaru, Ichiro Tsuji

FOOD & NUTRITION RESEARCH　55　2011年

DOI： 10.3402/fnr.v55i0.8326 　

ISSN：1654-6628

eISSN：1654-661X
Increased Risk of Severe Depression in Male Partners of Women With Breast Cancer 査読有り

Naoki Nakaya, Kumi Saito-Nakaya, Pernille Envold Bidstrup, Susanne Oksbjerg Dalton, Kirsten Frederiksen, Marianne Steding-Jessen, Yosuke Uchitomi, Christoffer Johansen

CANCER　116　(23)　5527-5534　2010年12月

DOI： 10.1002/cncr.25534 　

ISSN：0008-543X
RELATIONSHIPS BETWEEN N-TERMINAL PRO B-TYPE NATRIURETIC PEPTIDE AND INCIDENT DISABILITY AND MORTALITY IN OLDER COMMUNITY-DWELLING ADULTS: THE TSURUGAYA STUDY 査読有り

Atsushi Hozawa, Yumi Sugawara, Yasutake Tomata, Masako Kakizaki, Kaori Ohmori-Matsuda, Naoki Nakaya, Shinichi Kuriyama, Akira Fukao, Ichiro Tsuji

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY　58　(12)　2439-2441　2010年12月

DOI： 10.1111/j.1532-5415.2010.03190.x 　

ISSN：0002-8614
Impact of Nocturia on Bone Fracture and Mortality in Older Individuals: A Japanese Longitudinal Cohort Study 査読有り

Haruo Nakagawa, Kaijun Niu, Atsushi Hozawa, Yoshihiro Ikeda, Yasuhiro Kaiho, Kaori Ohmori-Matsuda, Naoki Nakaya, Shinichi Kuriyama, Satoru Ebihara, Ryoichi Nagatomi, Ichiro Tsuji, Yoichi Arai

JOURNAL OF UROLOGY　184　(4)　1413-1418　2010年10月

DOI： 10.1016/j.juro.2010.05.093 　

ISSN：0022-5347
Effect of Autogenic Training on General Improvement in Patients with Irritable Bowel Syndrome: A Randomized Controlled Trial 査読有り

Masae Shinozaki, Motoyori Kanazawa, Michiko Kano, Yuka Endo, Naoki Nakaya, Michio Hongo, Shin Fukudo

APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK　35　(3)　189-198　2010年9月

DOI： 10.1007/s10484-009-9125-y 　

ISSN：1090-0586
Personality Traits and Cancer Risk and Survival Based on Finnish and Swedish Registry Data 査読有り

Naoki Nakaya, Pernille E. Bidstrup, Kumi Saito-Nakaya, Kirsten Frederiksen, Markku Koskenvuo, Eero Pukkala, Jaakko Kaprio, Birgitta Floderus, Yosuke Uchitomi, Christoffer Johansen

AMERICAN JOURNAL OF EPIDEMIOLOGY　172　(4)　377-385　2010年8月

DOI： 10.1093/aje/kwq046 　

ISSN：0002-9262
[Depression and the risk of long-term care insurance certification: the Tsurugaya project]. 査読有り

Ohmori-Matsuda K, Hozawa A, Sone T, Koizumi-Masamune Y, Nakaya N, Kuriyama S, Suzuki S, Awata S, Tsuji I

[Nihon koshu eisei zasshi] Japanese journal of public health　57　(7)　538-549　2010年7月
出版者・発行元： 7
DOI： 10.11236/jph.57.7_538 　

ISSN：0546-1766

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目的地域高齢者におけるうつ状態の程度とその後の介護保険の要支援•要介護認定リスクとの関連をコホート研究により検討すること，さらにその関連に男女差があるかを検討すること。 方法仙台市宮城野区鶴ヶ谷地区の70歳以上住民全員（2,925人）に対し，高齢者総合機能評価「寝たきり予防健診」を平成15年に行った。受診者（958人）のうち，研究利用への同意が得られ介護保険認定非該当であった者841人を解析対象とした。うつ状態は30項目の Geriatric Depression Scale (GDS）で評価した。抗うつ薬内服または GDS14点以上（中等度～重度うつ群），10-13点（軽度うつ群），9 点以下（健常）の 3 群に分類し要支援•要介護認定リスクを Cox 比例ハザードモデルにより算出した。 結果 4 年間の追跡調査で151人が要支援•要介護認定を受け，46人が死亡した。うつ状態は特に男性において要支援•要介護認定リスクと関連していた。男性では，健常群と比較した要支援•要介護認定の年齢補正ハザード比は，軽度うつ群で1.77（95%信頼区間（CI）：0.91-3.48），中等度～重度うつ群で2.26（1.11-4.64）と，うつ状態の程度とともに有意に増加した（傾向性の P 値=0.023）。これは，疾患既往歴，ソーシャルサポートの有無，喫煙，認知機能などの影響を補正しても変わらなかった（多変量補正ハザード比；軽度うつ群：1.31（95%CI：0.65-2.65），中等度～重度うつ群：2.19（1.06-4.54），傾向性の P=0.034）。一方，女性では，うつ状態と要支援•要介護認定リスクとの間に有意な関連は認められなかった。また，うつ状態と死亡リスクには男女ともに有意な関連は認められなかった。 結論うつ状態と要支援•要介護認定リスクは，男性でのみ有意な関連が認められた。それは，ベースラインの既往歴，心身機能，社会的要因，生活習慣を補正してもなお認められた。うつ状態の要支援•要介護認定発生への影響は男女で異なる可能性が示唆された。地域高齢者のうつ対策が，生活の質の向上のみでなく，特に男性高齢者において，介護予防に重要であることが示された。
Gastric Hyposecretion in Esophageal Squamous-Cell Carcinomas 査読有り

K. Iijima, T. Koike, Y. Abe, H. Yamagishi, N. Ara, K. Asanuma, K. Uno, A. Imatani, N. Nakaya, S. Ohara, T. Shimosegawa

DIGESTIVE DISEASES AND SCIENCES　55　(5)　1349-1355　2010年5月

DOI： 10.1007/s10620-009-0853-x 　

ISSN：0163-2116
Coffee Consumption and Mortality Due to All Causes, Cardiovascular Disease, and Cancer in Japanese Women 査読有り

Kemmyo Sugiyama, Shinichi Kuriyama, Munira Akhter, Masako Kakizaki, Naoki Nakaya, Kaori Ohmori-Matsuda, Taichi Shimazu, Masato Nagai, Yumi Sugawara, Atsushi Hozawa, Akira Fukao, Ichiro Tsuji

JOURNAL OF NUTRITION　140　(5)　1007-1013　2010年5月

DOI： 10.3945/jn.109.109314 　

ISSN：0022-3166
The Ohsaki Cohort 2006 Study: Design of Study and Profile of Participants at Baseline 査読有り

Shinichi Kuriyama, Naoki Nakaya, Kaori Ohmori-Matsuda, Taichi Shimazu, Nobutaka Kikuchi, Masako Kakizaki, Toshimasa Sone, Fumi Sato, Masato Nagai, Yumi Sugawara, Yasutake Tomata, Munira Akhter, Mizuka Higashiguchi, Naru Fukuchi, Hideko Takahashi, Atsushi Hozawa, Ichiro Tsuji

JOURNAL OF EPIDEMIOLOGY　20　(3)　253-258　2010年5月

DOI： 10.2188/jea.JE20090093 　

ISSN：0917-5040
Association between green tea consumption and tooth loss: Cross-sectional results from the Ohsaki Cohort 2006 Study 査読有り

Yasushi Koyama, Shinichi Kuriyama, Jun Aida, Toshimasa Sone, Naoki Nakaya, Kaori Ohmori-Matsuda, Atsushi Hozawa, Ichiro Tsuji

PREVENTIVE MEDICINE　50　(4)　173-179　2010年4月

DOI： 10.1016/j.ypmed.2010.01.010 　

ISSN：0091-7435
社会的問題(退職・未就労リスクおよび離婚リスク)—Social issues among cancer survivors—特集がん患者のサバイバーシップ査読有り

中谷直樹, 中谷久美

腫瘍内科 = Clinical oncology / 腫瘍内科編集委員会編　5　(2)　122-130　2010年2月
出版者・発行元：東京 : 科学評論社
ISSN：1881-6568
QOLの向上のための各種患者支援プログラムの開発に関する研究がんリハビリテーションプログラムの開発

岡村仁, 安部能成, 阿部靖, 梅澤志乃, 大庭章, 緒方政美, 小野久美子, 木村浩彰, 栗原美穂, 酒井太一, 佐藤大介, 曽根稔雅, 田辺瑶子, 中谷直樹, 永田友美, 並木あかね, 濱口豊太, 吉原広和, 余宮きのみ

QOLの向上のための各種患者支援プログラムの開発に関する研究平成21年度総括・分担研究報告書　32-35　2010年
Dietary patterns associated with fall-related fracture in elderly Japanese: a population based prospective study 査読有り

Yasutake Monma, Kaijun Niu, Koh Iwasaki, Naoki Tomita, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Shin Takayama, Takashi Seki, Takashi Takeda, Nobuo Yaegashi, Satoru Ebihara, Hiroyuki Arai, Ryoichi Nagatomi, Ichiro Tsuji

BMC GERIATRICS　10　31　2010年

DOI： 10.1186/1471-2318-10-31 　

ISSN：1471-2318
Relationship between Peripheral Arterial Disease and Incident Disability among Elderly Japanese: the Tsurugaya Project 査読有り

Akemi Nitta, Atsushi Hozawa, Shinichi Kuriyama, Naoki Nakaya, Kaori Ohmori-Matsuda, Toshimasa Sone, Masako Kakizaki, Satoru Ebihara, Masataka Ichiki, Hiroyuki Arai, Ichiro Tsuji

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS　17　(12)　1290-1296　2010年

DOI： 10.5551/jat.5389 　

ISSN：1340-3478

eISSN：1880-3873
Green tea consumption and the risk of liver cancer in Japan: the Ohsaki Cohort study 査読有り

Akane Ui, Shinichi Kuriyama, Masako Kakizaki, Toshimasa Sone, Naoki Nakaya, Kaori Ohmori-Matsuda, Atsushi Hozawa, Yoshikazu Nishino, Ichiro Tsuji

CANCER CAUSES & CONTROL　20　(10)　1939-1945　2009年12月

DOI： 10.1007/s10552-009-9388-x 　

ISSN：0957-5243
Green tea consumption is associated with depressive symptoms in the elderly 査読有り

Kaijun Niu, Atsushi Hozawa, Shinichi Kuriyama, Satoru Ebihara, Hui Guo, Naoki Nakaya, Kaori Ohmori-Matsuda, Hideko Takahashi, Yayoi Masamune, Masanori Asada, Satoshi Sasaki, Hiroyuki Arai, Shuichi Awata, Ryoichi Nagatomi, Ichiro Tsuji

AMERICAN JOURNAL OF CLINICAL NUTRITION　90　(6)　1615-1622　2009年12月

DOI： 10.3945/ajcn.2009.28216 　

ISSN：0002-9165
Factors Associated With Psychological Distress in a Community-Dwelling Japanese Population: The Ohsaki Cohort 2006 Study 査読有り

Shinichi Kuriyama, Naoki Nakaya, Kaori Ohmori-Matsuda, Taichi Shimazu, Nobutaka Kikuchi, Masako Kakizaki, Toshimasa Sone, Fumi Sato, Masato Nagai, Yumi Sugawara, Munira Akhter, Mizuka Higashiguchi, Naru Fukuchi, Hideko Takahashi, Atsushi Hozawa, Ichiro Tsuji

JOURNAL OF EPIDEMIOLOGY　19　(6)　294-302　2009年11月

DOI： 10.2188/jea.JE20080076 　

ISSN：0917-5040
Mental Vulnerability and Survival After Cancer 査読有り

Naoki Nakaya, Pernille E. Bidstrup, Lene F. Eplov, Kumi Saito-Nakaya, Shinichi Kuriyama, Ichiro Tsuji, Yosuke Uchitomi, Christoffer Johansen

EPIDEMIOLOGY　20　(6)　916-920　2009年11月

DOI： 10.1097/EDE.0b013e3181b5f3b0 　

ISSN：1044-3983
Green tea consumption is associated with lower psychological distress in a general population: the Ohsaki Cohort 2006 Study 査読有り

Atsushi Hozawa, Shinichi Kuriyama, Naoki Nakaya, Kaori Ohmori-Matsuda, Masako Kakizaki, Toshimasa Sone, Masato Nagai, Yumi Sugawara, Akemi Nitta, Yasutake Tomata, Kaijun Niu, Ichiro Tsuji

AMERICAN JOURNAL OF CLINICAL NUTRITION　90　(5)　1390-1396　2009年11月

DOI： 10.3945/ajcn.2009.28214 　

ISSN：0002-9165
Green tea and death from pneumonia in Japan: the Ohsaki cohort study 査読有り

Ikue Watanabe, Shinichi Kuriyama, Masako Kakizaki, Toshimasa Sone, Kaori Ohmori-Matsuda, Naoki Nakaya, Atsushi Hozawa, Ichiro Tsuji

AMERICAN JOURNAL OF CLINICAL NUTRITION　90　(3)　672-679　2009年9月

DOI： 10.3945/ajcn.2009.27599 　

ISSN：0002-9165

eISSN：1938-3207
Green Tea Consumption and Hematologic Malignancies in Japan 査読有り

Toru Naganuma, Shinichi Kuriyama, Masako Kakizaki, Toshimasa Sone, Naoki Nakaya, Kaori Ohmori-Matsuda, Atsushi Hozawa, Yoshikazu Nishino, Ichiro Tsuji

AMERICAN JOURNAL OF EPIDEMIOLOGY　170　(6)　730-738　2009年9月

DOI： 10.1093/aje/kwp187 　

ISSN：0002-9262
Case-control study of green tea consumption and the risk of endometrial endometrioid adenocarcinoma 査読有り

Yukika Kakuta, Naoki Nakaya, Satoru Nagase, Megumi Fujita, Toshimitsu Koizumi, Chikako Okamura, Hitoshi Niikura, Kaori Ohmori, Shinichi Kuriyama, Toru Tase, Kiyoshi Ito, Yuko Minami, Nobuo Yaegashi, Ichiro Tsuji

CANCER CAUSES & CONTROL　20　(5)　617-624　2009年7月

DOI： 10.1007/s10552-008-9272-0 　

ISSN：0957-5243
Increase in body mass index category since age 20 years and all-cause mortality: a prospective cohort study (the Ohsaki Study) 査読有り

T. Shimazu, S. Kuriyama, K. Ohmori-Matsuda, N. Kikuchi, N. Nakaya, I. Tsuji

INTERNATIONAL JOURNAL OF OBESITY　33　(4)　490-496　2009年4月

DOI： 10.1038/ijo.2009.29 　

ISSN：0307-0565
Pain and Risk of Completed Suicide in Japanese Men: A Population-Based Cohort Study in Japan (Ohsaki Cohort Study) 査読有り

Nobutaka Kikuchi, Kaori Ohmori-Matsuda, Taichi Shimazu, Toshimasa Sone, Masako Kakizaki, Naoki Nakaya, Shinichi Kuriyama, Ichiro Tsuji

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT　37　(3)　316-324　2009年3月

DOI： 10.1016/j.jpainsymman.2008.03.012 　

ISSN：0885-3924
Personality and Gastric Cancer Screening Attendance: A Cross-Sectional Analysis from the Miyagi Cohort Study 査読有り

Shizuha Arai, Naoki Nakaya, Masako Kakizaki, Kaori Ohmori-Matsuda, Taichi Shimazu, Shinichi Kuriyama, Akira Fukao, Ichiro Tsuji

JOURNAL OF EPIDEMIOLOGY　19　(1)　34-40　2009年1月

DOI： 10.2188/jea.JE20080024 　

ISSN：0917-5040
Coffee Consumption and the Risk of Oral, Pharyngeal, and Esophageal Cancers in Japan The Miyagi Cohort Study 査読有り

Toru Naganuma, Shinichi Kuriyama, Masako Kakizaki, Toshimasa Sone, Naoki Nakaya, Kaori Ohmori-Matsuda, Yoshikazu Nishino, Akira Fukao, Ichiro Tsuji

AMERICAN JOURNAL OF EPIDEMIOLOGY　168　(12)　1425-1432　2008年12月

DOI： 10.1093/aje/kwn282 　

ISSN：0002-9262
No effect of the Trp64Arg variant of the beta(3)-adrenergic receptor gene on weight loss by diet and exercise intervention among Japanese adults 査読有り

Shinichi Kuriyama, Taichi Shimazu, Atsushi Hozawa, Shigeo Kure, Naoyuki Kurokawa, Masako Kakizaki, Toshimasa Sone, Kaori Matsuda-Ohmori, Naoki Nakaya, Hiroshi Satoh, Ichiro Tsuji

METABOLISM-CLINICAL AND EXPERIMENTAL　57　(11)　1570-1575　2008年11月

DOI： 10.1016/j.metabol.2008.06.013 　

ISSN：0026-0495
Sleep duration and the risk of breast cancer: the Ohsaki Cohort Study 査読有り

M. Kakizaki, S. Kuriyama, T. Sone, K. Ohmori-Matsuda, A. Hozawa, N. Nakaya, S. Fukudo, I. Tsuji

BRITISH JOURNAL OF CANCER　99　(9)　1502-1505　2008年10月

DOI： 10.1038/sj.bjc.6604684 　

ISSN：0007-0920
Marital status and non-small cell lung cancer survival: the Lung Cancer Database Project in Japan 査読有り

Kumi Saito-Nakaya, Naoki Nakaya, Tatsuo Akechi, Masatoshi Inagaki, Mariko Asai, Koichi Goto, Kanji Nagai, Yutaka Nishiwaki, Shoichiro Tsugane, Shin Fukudo, Yosuke Uchitomi

PSYCHO-ONCOLOGY　17　(9)　869-876　2008年9月

DOI： 10.1002/pon.1296 　

ISSN：1057-9249
Green tea consumption and lung cancer risk: the Ohsaki study 査読有り

Q. Li, M. Kakizaki, S. Kuriyama, T. Sone, H. Yan, N. Nakaya, K. Mastuda-Ohmori, I. Tsuji

BRITISH JOURNAL OF CANCER　99　(7)　1179-1184　2008年9月

DOI： 10.1038/sj.bjc.6604645 　

ISSN：0007-0920
Case-control study of coffee consumption and the risk of endometrial endometrioid adenocarcinoma 査読有り

Toshimitsu Koizumi, Naoki Nakaya, Chikako Okamura, Yuki Sato, Taichi Shimazu, Satoru Nagase, Hitoshi Niikura, Shinichi Kuriyama, Toru Tase, Kiyoshi Ito, Yoshitaka Tsubono, Kunihiro Okamura, Nobuo Yaegashi, Ichiro Tsuj

EUROPEAN JOURNAL OF CANCER PREVENTION　17　(4)　358-363　2008年8月

DOI： 10.1097/CEJ.0b013e3282f0c02c 　

ISSN：0959-8278
低栄養と介護保険認定・死亡リスクに関するコホート研究鶴ヶ谷プロジェクト

東口みづか, 中谷直樹, 大森芳, 島津太一, 曽根稔雅, 寳澤篤, 栗山進一, 辻一郎

日本公衆衛生雑誌　55　(7)　433-439　2008年7月
出版者・発行元：日本公衆衛生学会
ISSN：0546-1766

eISSN：2187-8986
Mass screening-based case-control study of diet and prostate cancer in Changchun, China 査読有り

Xiao-Meng Li, Jiang Li, Ichiro Tsuji, Naoki Nakaya, Yoshikazu Nishino, Xue-Jian Zhao

ASIAN JOURNAL OF ANDROLOGY　10　(4)　551-560　2008年7月

DOI： 10.1111/j.1745-7262.2008.00384.x 　

ISSN：1008-682X

eISSN：1745-7262
Sleep duration and the risk of prostate cancer: the Ohsaki Cohort Study 査読有り

M. Kakizaki, K. Inoue, S. Kuriyama, T. Sone, K. Matsuda-Ohmori, N. Nakaya, S. Fukudo, I. Tsuji

BRITISH JOURNAL OF CANCER　99　(1)　176-178　2008年7月

DOI： 10.1038/sj.bjc.6604425 　

ISSN：0007-0920
Sense of life worth living (ikigai) and mortality in Japan: Ohsaki Study 査読有り

Toshimasa Sone, Naoki Nakaya, Kaori Ohmori, Taichi Shimazu, Mizuka Higashiguchi, Masako Kakizaki, Nobutaka Kikuchi, Shinichi Kuriyama, Ichiro Tsuji

PSYCHOSOMATIC MEDICINE　70　(6)　709-715　2008年7月

DOI： 10.1097/PSY.0b013e31817e7e64 　

ISSN：0033-3174
[Malnutrition and the risk of long-term care insurance certification or mortality. A cohort study of the Tsurugaya project]. 査読有り

Higashiguchi M, Nakaya N, Ohmori K, Shimazu T, Sone T, Hozawa A, Kuriyama S, Tsuji I

[Nihon koshu eisei zasshi] Japanese journal of public health　55　433-439　2008年7月
出版者・発行元： 7
DOI： 10.11236/jph.55.7_433 　

ISSN：0546-1766
Negative psychological aspects and survival in lung cancer patients 査読有り

Naoki Nakaya, Kumi Saito-Nakaya, Tatsuo Akechi, Shinichi Kuriyama, Masatoshi Inagaki, Nobutaka Kikuchi, Kanji Nagai, Shoichiro Tsugane, Yutaka Nishiwaki, Ichiro Tsuji, Yosuke Uchitomi

PSYCHO-ONCOLOGY　17　(5)　466-473　2008年5月

DOI： 10.1002/pon.1259 　

ISSN：1057-9249
Association between nocturia and fractures in a community-dwelling elderly population aged 70 years and over: Results of a 3-year prospective cohort study in Japan 査読有り

Haruo Nakagawa, Yoshihiro Ikeda, Yasuhiro Kaiho, Naoki Nakaya, Kaori Omori, Kaun Niu, Shinichi Kuriyama, Ryoichi Nagatomi, Ichiro Tsuji, Ydichi Arai

JOURNAL OF UROLOGY　179　(4)　143-143　2008年4月

DOI： 10.1016/S0022-5347(08)60410-3 　

ISSN：0022-5347
Home blood pressure is associated with depressive symptoms in an elderly population aged 70 years and over: A population-based, cross-sectional analysis 査読有り

Kaijun Niu, Atsushi Hozawa, Shuichi Awata, Hui Guo, Shinichi Kuriyama, Toru Sek, Kaori Ohmori-Matsuda, Naoki Nakaya, Satoru Ebihara, Yun Wang, Ichiro Tsuji, Ryoichi Nagatomi

HYPERTENSION RESEARCH　31　(3)　409-416　2008年3月

DOI： 10.1291/hypres.31.409 　

ISSN：0916-9636

eISSN：1348-4214
Survey of the current status of cancer rehabilitation in Japan 査読有り

Toyohiro Hamaguchi, Hitoshi Okamura, Naoki Nakaya, Kazunari Abe, Yasushi Abe, Shino Umezawa, Miho Kurihara, Kumi Nakaya, Kinomi Yomiya, Yosuke Uchitomi

DISABILITY AND REHABILITATION　30　(7)　559-564　2008年

DOI： 10.1080/09638280701377003 　

ISSN：0963-8288
Personality and body mass index: A cross-sectional analysis from the Miyagi Cohort Study 査読有り

Masako Kakizaki, Shinichi Kuriyarna, Yuki Sato, Taichi Shimazu, Kaori Matsuda-Ohmori, Naoki Nakaya, Akira Fukao, Shin Fukudo, Ichiro Tsuji

JOURNAL OF PSYCHOSOMATIC RESEARCH　64　(1)　71-80　2008年1月

DOI： 10.1016/j.jpsychores.2007.07.008 　

ISSN：0022-3999
Fish intake and the risk of prostate cancer in Japan: A prospective cohort study 査読有り

Fumi Sato, Taichi Shimazu, Shinichi Kuriyama, Kaori Ohmori, Naoki Nakaya, Ichiro Tsuji, Yoichi Arai

Japanese Journal of Urology　99　(1)　14-21　2008年
出版者・発行元： Japanese Urological Association
DOI： 10.5980/jpnjurol1989.99.14 　

ISSN：0021-5287
Serum C-Reactive Protein Even at Very Low (< 1.0 mg/l) Concentration Is Associated with Physical Performance in a Community-Based Elderly Population Aged 70 Years and Over 査読有り

Kaijun Niu, Atsushi Hozawa, Hui Guo, Shinichi Kuriyama, Satoru Ebihara, Guang Yang, Kaori Ohmori-Matsuda, Naoki Nakaya, Hideko Takahashi, Kazuki Fujita, Shirong Wen, Hiroyuki Arai, Ichiro Tsuji, Ryoichi Nagatomi

GERONTOLOGY　54　(5)　260-267　2008年

DOI： 10.1159/000134286 　

ISSN：0304-324X
Alcohol consumption and suicide mortality among Japanese men: the Ohsaki Study 査読有り

Naoki Nakaya, Nobutaka Kikuchi, Taichi Shimazu, Kaori Ohmori, Masako Kakizaki, Toshimasa Sone, Shuichi Awata, Shinichi Kuriyama, Ichiro Tsuji

ALCOHOL　41　(7)　503-510　2007年11月

DOI： 10.1016/j.alcohol.2007.08.001 　

ISSN：0741-8329
Time spent walking and risk of colorectal cancer in Japan: The Miyaqi Cohort Study 査読有り

Hideko Takahashi, Shinichi Kuriyama, Yoshitaka Tsubono, Naoki Nakaya, Kazuki Fujita, Yoshikazu Nishino, Daisuke Shibuya, Ichiro Tsuji

EUROPEAN JOURNAL OF CANCER PREVENTION　16　(5)　403-408　2007年10月

DOI： 10.1097/01.cej.0000236249.63489.05 　

ISSN：0959-8278
Extensive gastric atrophy: An increased risk factor for superficial esophageal squamous cell carcinoma in Japan 査読有り

Katsunori Iijima, Tomoyuk Koike, Yasuhiko Abe, Yoshifumi Inomata, Hitoshi Sekine, Akira Imatani, Naoki Nakaya, Shuichi Ohara, Tooru Shimosegawa

AMERICAN JOURNAL OF GASTROENTEROLOGY　102　(8)　1603-1609　2007年8月

DOI： 10.1111/j.1572-0241.2007.01257.x 　

ISSN：0002-9270
Dietary patterns and cardiovascular disease mortality in Japan: a prospective cohort study 査読有り

Taichi Shimazu, Shinichi Kuriyama, Atsushi Hozawa, Kaori Ohmori, Yuki Sato, Naoki Nakaya, Yoshikazu Nishino, Yoshitaka Tsubono, Ichiro Tsuji

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY　36　(3)　600-609　2007年6月

DOI： 10.1093/ije/dym005 　

ISSN：0300-5771
Coffee consumption and the risk of colorectal cancer: A prospective cohort study in Japan 査読有り

Toru Naganuma, Shinichi Kuriyama, Munira Akhter, Masako Kakizaki, Naoki Nakaya, Kaori Matsuda-Ohmori, Taichi Shimazu, Akira Fukao, Ichiro Tsuji

INTERNATIONAL JOURNAL OF CANCER　120　(7)　1542-1547　2007年4月

DOI： 10.1002/ijc.22505 　

ISSN：0020-7136
The joint impact of cardiovascular risk factors upon medical costs 査読有り

Kaori Ohmori-Matsuda, Shinichi Kuriyama, Atsushi Hozawa, Naoki Nakaya, Taichi Shimazu, Ichiro Tsuji

PREVENTIVE MEDICINE　44　(4)　349-355　2007年4月

DOI： 10.1016/j.ypmed.2006.11.020 　

ISSN：0091-7435
Cigarette smoking and the risk of colorectal cancer among men: a prospective study in Japan 査読有り

Munlra Akhter, Yoshikazu Nishino, Naoki Nakaya, Kayoko Kurashima, Yuki Sato, Shinichi Kuriyama, Yoshitaka Tsubono, Ichiro Tsuji

EUROPEAN JOURNAL OF CANCER PREVENTION　16　(2)　102-107　2007年4月

DOI： 10.1097/01.cej.0000228412.98847.bc 　

ISSN：0959-8278
Validity and utility of the Japanese version of the WHO-Five Well-Being Index in the context of detecting suicidal ideation in elderly community residents 査読有り

S. Awata, P. Bech, Y. Koizum, T. Seki, S. Kuriyama, A. Hozawa, K. Ohmori, N. Nakaya, H. Matsuoka, I. Tsuji

INTERNATIONAL PSYCHOGERIATRICS　19　(1)　77-88　2007年2月

DOI： 10.1017/S1041610206004212 　

ISSN：1041-6102
Lower risk of death from gastric cancer among participants of gastric cancer screening in Japan: A population-based cohort study 査読有り

Akira Miyamoto, Shinichi Kuriyama, Yoshikazu Nishino, Yoshitaka Tsubono, Naoki Nakaya, Kaori Ohmori, Kayoko Kurashima, Daisuke Shibuya, Ichiro Tsuji

PREVENTIVE MEDICINE　44　(1)　12-19　2007年1月

DOI： 10.1016/j.ypmed.2006.07.016 　

ISSN：0091-7435
Alcohol consumption is associated with an increased risk of distal colon and rectal cancer in Japanese men: The Miyagi Cohort Study 査読有り

Munira Akhter, Shinichi Kuriyama, Naoki Nakaya, Taichi Shimazu, Kaori Ohmori, Yoshikazu Nishino, Yoshitaka Tsubono, Akira Fukao, Ichiro Tsuji

EUROPEAN JOURNAL OF CANCER　43　(2)　383-390　2007年1月

DOI： 10.1016/j.ejca.2006.09.020 　

ISSN：0959-8049
Psychometric properties of the Japanese version of the quality of life-Cancer Survivors Instrument 査読有り

Maiko Fujimori, Makoto Kobayakawa, Naoki Nakaya, Kanji Nagai, Yutaka Nishiwaki, Masatoshi Inagaki, Yosuke Uchitomi

QUALITY OF LIFE RESEARCH　15　(10)　1633-1638　2006年12月

DOI： 10.1007/s11136-006-0038-4 　

ISSN：0962-9343
Impact of non-dietary nutrients intake on misclassification in the estimation of nutrient intake in epidemiologic study 査読有り

Mikiko Ogata, Shinichi Kuriyama, Yuki Sato, Taichi Shimazu, Naoki Nakaya, Kaori Ohmori, Atsushi Hozawa, Ichiro Tsuji

JOURNAL OF EPIDEMIOLOGY　16　(5)　193-200　2006年9月

DOI： 10.2188/jea.16.193 　

ISSN：0917-5040
Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan - The Ohsaki Study 査読有り

Shinichi Kuriyama, Taichi Shimazu, Kaori Ohmori, Nobutaka Kikuchi, Naoki Nakaya, Yoshikazu Nishino, Yoshitaka Tsubono, Ichiro Tsuji

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION　296　(10)　1255-1265　2006年9月

DOI： 10.1001/jama.296.10.1255 　

ISSN：0098-7484
No association between green tea and prostate cancer risk in Japanese men: the Ohsaki Cohort Study 査読有り

N. Kikuchi, K. Ohmori, T. Shimazu, N. Nakaya, S. Kuriyama, Y. Nishino, Y. Tsubono, I. Tsuji

BRITISH JOURNAL OF CANCER　95　(3)　371-373　2006年8月

DOI： 10.1038/sj.bjc.6603230 　

ISSN：0007-0920
Personality traits and cancer survival: a Danish cohort study 査読有り

N. Nakaya, P. E. Hansen, I. R. Schapiro, L. F. Eplov, K. Saito-Nakaya, Y. Uchitomi, C. Johansen

BRITISH JOURNAL OF CANCER　95　(2)　146-152　2006年7月

DOI： 10.1038/sj.bjc.6603244 　

ISSN：0007-0920
Dietary long-chain n-3 fatty acids of marine origin and serum C-reactive protein concentrations are associated in a population with a diet rich in marine products 査読有り

Kaijun Niu, Atsushi Hozawa, Shinichi Kuriyama, Kaori Ohmori-Matsuda, Taichi Shimazu, Naoki Nakaya, Kazuki Fujita, Ichiro Tsuji, Ryoichi Nagatomi

AMERICAN JOURNAL OF CLINICAL NUTRITION　84　(1)　223-229　2006年7月

DOI： 10.1093/ajcn/84.1.223 　

ISSN：0002-9165
Meat consumption and risk of colorectal cancer in Japan: The Miyagi cohort study 査読有り

Y Sato, N Nakaya, S Kuriyama, Y Nishino, Y Tsubono, Tsuji, I

EUROPEAN JOURNAL OF CANCER PREVENTION　15　(3)　211-218　2006年6月

DOI： 10.1097/01.cej.0000197455.87356.05 　

ISSN：0959-8278
The lung cancer database project at the National Cancer Center, Japan: Study design, corresponding rate and profiles of cohort 査読有り

N Nakaya, K Goto, K Saito-Nakaya, M Inagaki, T Otani, T Akechi, K Nagai, F Hojo, Y Uchitomi, S Tsugane, Y Nishiwaki

JAPANESE JOURNAL OF CLINICAL ONCOLOGY　36　(5)　280-284　2006年5月

DOI： 10.1093/jjco/hyl015 　

ISSN：0368-2811

eISSN：1465-3621
Prefrontal cortex and amygdala volume in first minor or major depressive episode after cancer diagnosis 査読有り

E Yoshikawa, Y Matsuoka, H Yamasue, M Inagaki, T Nakano, T Akechi, M Kobayakawa, M Fujimori, N Nakaya, N Akizuki, S Imoto, K Murakami, K Kasai, Y Uchitomi

BIOLOGICAL PSYCHIATRY　59　(8)　707-712　2006年4月

DOI： 10.1016/j.biopsych.2005.08.018 　

ISSN：0006-3223
Depression and survival in patients with non-small cell lung cancer after curative resection: a preliminary study 査読有り

N Nakaya, K Saito-Nakaya, N Akizuki, E Yoshikawa, M Kobayakawa, M Fujimori, K Nagai, Y Nishiwaki, S Fukudo, Y Tsubono, Y Uchitomi

CANCER SCIENCE　97　(3)　199-205　2006年3月

DOI： 10.1111/j.1349-7006.2006.00160.x 　

ISSN：1347-9032

eISSN：1349-7006
Marital status, social support and survival after curative resection in non-small-cell lung cancer 査読有り

K Saito-Nakaya, N Nakaya, M Fujimori, N Akizuki, E Yoshikawa, M Kobayakawa, K Nagai, Y Nishiwaki, Y Tsubono, Y Uchitomi

CANCER SCIENCE　97　(3)　206-213　2006年3月

DOI： 10.1111/j.1349-7006.2006.00159.x 　

ISSN：1347-9032

eISSN：1349-7006
Dietary intakes and plasma 8-iso-prostaglandin F-2 alpha concentrations in community-dwelling elderly Japanese: The Tsurugaya Project 査読有り

Shinichi Kuriyama, Satoru Ebihara, Atsushi Hozawa, Kaori Ohmori, Kayoko Kurashima, Naoki Nakaya, Toshifumi Matsui, Hiroyuki Arai, Yoshitaka Tsubono, Hidetada Sasaki, Ichiro Tsuji

INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH　76　(2)　87-94　2006年3月

DOI： 10.1024/0300-9831.76.2.87 　

ISSN：0300-9831
No adverse effects of adjuvant chemotherapy on hippocampal volume in Japanese breast cancer survivors 査読有り

E Yoshikawa, Y Matsuoka, M Inagaki, T Nakano, T Akechi, M Kobayakawa, M Fujimori, N Nakaya, N Akizuki, S Imoto, K Murakami, Y Uchitomi

BREAST CANCER RESEARCH AND TREATMENT　92　(1)　81-84　2005年7月

DOI： 10.1007/s10549-005-1412-6 　

ISSN：0167-6806
Green tea and the risk of colorectal cancer: Pooled analysis of two prospective studies in Japan 査読有り

Y Suzuki, Y Tsubono, N Nakaya, Y Koizumi, Y Suzuki, D Shibuya, Tsuji, I

JOURNAL OF EPIDEMIOLOGY　15　(4)　118-124　2005年7月

DOI： 10.2188/jea.15.118 　

ISSN：0917-5040
Personality and cancer survival: the Miyagi cohort study 査読有り

N Nakaya, Y Tsubono, Y Nishino, T Hosokawa, S Fukudo, D Shibuya, N Akizuki, E Yoshikawa, M Kobayakawa, M Fujimori, K Saito-Nakaya, Y Uchitomi, Tsuji, I

BRITISH JOURNAL OF CANCER　92　(11)　2089-2094　2005年6月

DOI： 10.1038/sj.bjc.6602610 　

ISSN：0007-0920
Fruit and vegetable consumption and risk of colorectal cancer in Japan: The Miyagi Cohort Study 査読有り

Y Sato, Y Tsubono, N Nakaya, K Ogawa, K Kurashima, S Kuriyama, A Hozawa, Y Nishino, D Shibuya, Tsuji, I

PUBLIC HEALTH NUTRITION　8　(3)　309-314　2005年5月

DOI： 10.1079/PHN2004681 　

ISSN：1368-9800
Alcohol consumption and the risk of cancer in Japanese men: the Miyagi cohort study 査読有り

N Nakaya, Y Tsubono, S Kuriyama, A Hozawa, T Shimazu, K Kurashima, S Fukudo, D Shibuya, Tsuji, I

EUROPEAN JOURNAL OF CANCER PREVENTION　14　(2)　169-174　2005年4月

DOI： 10.1097/00008469-200504000-00013 　

ISSN：0959-8278
Personality and mortality from ischemic heart disease and stroke 査読有り

N Nakaya, Y Tsubono, T Hosokawa, A Hozawa, S Kuriyama, S Fukudo, Tsuji, I

CLINICAL AND EXPERIMENTAL HYPERTENSION　27　(2-3)　297-305　2005年2月

DOI： 10.1081/CEH-200048930 　

ISSN：1064-1963
Twenty-four-hour urinary cortisol levels before complete resection of non-small cell lung cancer and survival 査読有り

N Nakaya, S Fukudo, N Akizuki, E Yoshikawa, M Kobayakawa, M Fujimori, K Shimizu, K Nagai, Y Nishiwaki, Y Uchitomi

ACTA ONCOLOGICA　44　(4)　399-405　2005年

DOI： 10.1080/02841860510029635 　

ISSN：0284-186X

eISSN：1651-226X
Cigarette smoking and the risk of gastric cancer: A pooled analysis of two prospective studies in Japan 査読有り

Y Koizumi, Y Tsubono, N Nakaya, S Kuriyama, D Shibuya, H Matsuoka, Tsuji, I

INTERNATIONAL JOURNAL OF CANCER　112　(6)　1049-1055　2004年12月

DOI： 10.1002/ijc.20518 　

ISSN：0020-7136
Constipation, laxative use and risk of colorectal cancer: The Miyagi Cohort Study 査読有り

T Watanabe, N Nakaya, K Kurashima, S Kuriyama, Y Tsubono, Tsuji, I

EUROPEAN JOURNAL OF CANCER　40　(14)　2109-2115　2004年9月

DOI： 10.1016/j.ejca.2004.06.014 　

ISSN：0959-8049
[A survey regarding the implementation of cancer screening among municipalities in Japan]. 査読有り

Nakaya N, Ohmori K, Suzuki Y, Hozawa A, Kuriyama S, Tsubono Y, Tsuji I

[Nihon koshu eisei zasshi] Japanese journal of public health　51　530-539　2004年7月
出版者・発行元： 7
DOI： 10.11236/jph.51.7_530 　

ISSN：0546-1766
Green tea and the risk of breast cancer: pooled analysis of two prospective studies in Japan 査読有り

Y Suzuki, Y Tsubono, N Nakaya, Y Suzuki, Y Koizumi, Tsuji, I

BRITISH JOURNAL OF CANCER　90　(7)　1361-1363　2004年4月

DOI： 10.1038/sj.bjc.6601652 　

ISSN：0007-0920
Laterality and imbalance of muscle stiffness relate to personality 査読有り

Naoki Nakaya, Hiroaki Kumano, Keiji Minoda, Motoyori Kanazawa, Shin Fukudo

Behavioral Medicine　30　(1)　5-9　2004年3月
出版者・発行元： 1
DOI： 10.3200/BMED.30.1.5-10 　

ISSN：0896-4289
Follow-up and mortality profiles in the Miyagi Cohort Study 査読有り

Tsuji, I, Y Nishino, Y Tsubono, Y Suzuki, A Hozawa, N Nakaya, K Fujita, S Kuriyama, D Shibuya, A Fukao, S Hisamichi

JOURNAL OF EPIDEMIOLOGY　14　S2-S6　2004年2月

DOI： 10.2188/jea.14.S2 　

ISSN：0917-5040
Alcohol consumption and mortality in Japan: The Miyagi Cohort Study 査読有り

N Nakaya, K Kurashima, J Yamaguchi, T Ohkubo, Y Nishino, Y Tsubono, D Shibuya, S Fukudo, A Fukao, Tsuji, I, S Hisamichi

JOURNAL OF EPIDEMIOLOGY　14　S18-S25　2004年2月

DOI： 10.2188/jea.14.S18 　

ISSN：0917-5040
Body mass index and mortality in Japan: The Miyagi Cohort Study 査読有り

S Kuriyama, K Ohmori, C Miura, Y Suzuki, N Nakaya, K Fujita, Y Sato, Y Tsubono, Tsuji, I, A Fukao, S Hisamichi

JOURNAL OF EPIDEMIOLOGY　14　S33-S38　2004年2月

DOI： 10.2188/jea.14.S33 　

ISSN：0917-5040
Health practices and mortality in Japan: Combined effects of smoking, drinking, walking and body mass index in the Miyagi Cohort Study 査読有り

Y Tsubono, Y Koizumi, N Nakaya, K Fujita, H Takahashi, A Hozawa, Y Suzuki, S Kuriyama, Tsuji, I, A Fukao, S Hisamichi

JOURNAL OF EPIDEMIOLOGY　14　S39-S45　2004年2月

DOI： 10.2188/jea.14.S39 　

ISSN：0917-5040
パーソナリティーと虚血性心疾患および脳血管疾患に関する前向きコホート研究(第56回日本心身医学会東北地方会演題抄録)

中谷直樹, 坪野吉孝, 細川徹, 西野善一, 渋谷大助, 福土審, 辻一郎

心身医学　44　(2)　156-156　2004年
出版者・発行元：一般社団法人日本心身医学会
DOI： 10.15064/jjpm.44.2_156_1 　
都市在住の高齢者におけるソーシャル・サポートと抑うつ症状の関連性査読有り

小泉弥生, 荒井啓行, 辻一郎, 粟田主一, 関徹, 中谷直樹, 栗山進一, 鈴木寿則, 大森芳, 寳澤篤, 海老原覚

日本老年医学会雑誌　41　(4)　426-433　2004年
出版者・発行元：一般社団法人日本老年医学会
DOI： 10.3143/geriatrics.41.426 　

ISSN：0300-9173

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都市在住の高齢者におけるソーシャル・サポートと抑うつ症状の関連を明らかにするため, 仙台市T地区の70歳以上住民に対し総合機能評価を平成14年7月から8月に行った. 対象2,730人のうち1,198人が参加し, 聞き取り調査を受けた. ソーシャル・サポートに関しては, 村岡ら (1996) の調査票により (i) 困ったときの相談相手, (ii) 体の具合の悪いときの相談相手, (iii) 家事などの日常生活を援助してくれる人, (iv) 具合の悪いとき病院に連れて行ってくれる人, (v) 寝込んだとき身の回りの世話をしてくれる人の有無を尋ねた. 抑うつ症状の評価は Geriatric Depression Scale (GDS) 30項目を用い, GDSに回答した1,170人のうち, Mini-Mental State Examination (MMSE) が18点以上で研究に同意した1,146人を解析対象とした. GDS 10点以下を非抑うつ群, 11点以上または抗うつ剤服用者を抑うつ群とした. ソーシャル・サポートの欠如と抑うつ症状の出現に関する多変量補正オッズ比 (95%信頼区間) を (i) から (v)の各項目について, 多重ロジスティック回帰分析により算出した. その際, 年齢, 配偶者の有無, 同居人数, 既往疾患数, 教育レベル, 認知機能, 運動能力, 痛み, 主観的健康度を補正した. 抑うつ群は男性134人 (27.9%), 女性259人 (38.9%) であった. 質問 (i) から (v) まで各々の「ある」者に比べて「ない」者では抑うつ症状出現のオッズ比 (95%信頼区間) は, 男性では (i) 2.5 (1.5～4.1), (ii) 1.9 (1.1～3.2), (iii) 2.7 (1.7～4.4), (iv) 1.9 (1.1～3.2), (v) 2.8 (1.6～4.9) と全項目で有意に上昇した. 女性では (i) 1.2 (0.8～1.8), (ii) 1.2 (0.8～1.8), (iii) 1.4 (1.0～2.0), (iv) 1.6 (1.1～2.3), (v) 2.0 (1.4～2.9) と (iii), (iv), (v) の項目で有意にオッズ比が上昇した. 都市部高齢者では男女ともソーシャル・サポートの欠如と抑うつ症状との間に有意な関連があった. しかも男性では, 関連するソーシャル・サポートの種類と関連の強さの両面において影響が顕著であった.
Preliminary study: Psychological effects of muscle relaxation on juvenile delinquents 査読有り

N Nakaya, H Kumano, K Minoda, T Koguchi, K Tanouchi, M Kanazawa, S Fukudo

INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE　11　(3)　176-180　2004年

DOI： 10.1207/s15327558ijbm1103_6 　

ISSN：1070-5503
Personality and the risk of cancer 査読有り

N Nakaya, Y Tsubono, T Hosokawa, Y Nishino, T Ohkubo, A Hozawa, D Shibuya, S Fukudo, A Fukao, Tsuji, I, S Hisamichi

JOURNAL OF THE NATIONAL CANCER INSTITUTE　95　(11)　799-805　2003年6月

ISSN：0027-8874
No association between green tea and the risk of gastric cancer: Pooled analysis of two prospective studies in Japan 査読有り

Y Koizumi, Y Tsubono, N Nakaya, Y Nishino, D Shibuya, H Matsuoka, Tsuji, I

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION　12　(5)　472-473　2003年5月

ISSN：1055-9965
Increased risk of irritable bowel syndrome in depressive individuals in elderly population 査読有り

N Nakaya, K Saito, K Kurashima, A Hozawa, M Kanazawa, S Fukudo, Tsuji, I

GASTROENTEROLOGY　124　(4)　A86-A86　2003年4月

ISSN：0016-5085
長期加療中脳卒中患者の心理的ストレス状況と筋弾性との関係

濱口豊太, 中谷直樹, 奈良進弘, 赤松郁夫

新潟医療福祉学会誌　3　(1)　77-82　2003年3月
出版者・発行元：新潟医療福祉大学
ISSN：1346-8774

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不安と筋緊張が関連することはよく知られている。本研究は、長期加療中の脳卒中患者は、心理的ストレスが高く、かつ筋緊張が高いという仮説を症例対照研究にて検証した。対象は脳卒中患者10例、健常者19例。筋弾性計(PEK-1)を用い、対象者における左右の上腕二頭筋・上腕三頭筋・手指および手関節屈筋群・手指および手関節伸筋群・僧帽筋を測定した。心理的指標は、心理的ストレス反応尺度(PsychologicalStress Response Scale)を用いた。本研究では、長期加療中の脳卒中患者において、心理的ストレス反応における抑うつと怒りのスコアが高値を示した。一方、脳卒中患者群の筋弾性値は健常者と差はなく、脳卒中患者における抑うつ気分が、心身相関により、筋緊張と関連することは見いだせなかった。長期加療中の脳卒中患者において、心理ストレス反応が高いことから、心理面への支援の重要性が示唆された。
都市に在住する70歳以上の高齢者のソーシャルサポートと抑うつ症状との関連性 (老年精神医学雑誌)

小泉弥生, 粟田主一, 関徹, 松岡洋夫, 中谷直樹, 栗山進一, 大森芳, 寳澤篤, 辻一郎, 藤田和樹, 永富良一, 海老原覚, 荒井啓行

老年精神医学雑誌　14　(5)　629-629　2003年
出版者・発行元： (株)ワールドプランニング
ISSN：0915-6305
Validation of walking questionnaire for population-based prospective studies in Japan: Comparison with pedometer 査読有り

Yoshitaka Tsubono, Ichiro Tsuji, Kazuki Fujita, Naoki Nakaya, Atsushi Hozawa, Takayoshi Ohkubo, Aya Kuwahara, Yoko Watanabe, Keiko Ogawa, Yoshikazu Nishino, Shigeru Hisamichi

Journal of Epidemiology　12　(4)　305-309　2002年
出版者・発行元： Japan Epidemiology Association
DOI： 10.2188/jea.12.305 　

ISSN：1349-9092 0917-5040
筋弾性とEMG及び心理的指標との関連

濱口, 豊太, 中谷, 直樹

国際医療福祉大学紀要 = Bulletin of International University of Health and Welfare　6　(0)　23-28　2001年12月22日
出版者・発行元：国際医療福祉大学
ISSN：1342-4661

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本研究の目的は、リハビリテーションの臨床において簡便な筋緊張評価を可能にし、筋緊張と心理的指標との関連を検証することである。対象は健常者19名とし、筋緊張は左右の僧帽筋、上腕二頭筋、上腕三頭筋、手指および手関節伸筋群、手指および手関節屈筋群を測定した。心理指標はEysenck Personality Questionnaire-Revised (EPQ-R)、Psychological Strees Response Scale (PSRS)、ordinate scaleの3つの心理指標による評価を行った。筋弾性計による測定と積分筋電図との高い相関を示した(r=0.44-0.76)。筋弾性の左右差では、痛み(r=0.51,p<0.05),不安感(r=0.48,p<0.05)との有意な相関を示した。本研究は、リハビリテーションにおける筋緊張評価として、筋弾性計を用いることができる可能性を示した。また、筋緊張と心理・行動面が相関することが示唆された。
1.筋緊張と心理面との関連 : 左右差及び局所の状態の重要性(第50回日本心身医学会東北地方会プログラム・抄録集)

中谷直樹, 熊野宏昭, 美野田啓二, 福土審

心身医学　41　(6)　471-471　2001年
出版者・発行元：一般社団法人日本心身医学会
DOI： 10.15064/jjpm.41.6_471_1 　
14.筋骨格系の歪みとパーソナリティおよび心理的ストレス反応との関連の検討(第49回日本心身医学会東北地方会演題抄録)

中谷直樹, 熊野宏昭, 美野田啓二, 福土審

心身医学　41　(4)　300-300　2001年
出版者・発行元：一般社団法人日本心身医学会
DOI： 10.15064/jjpm.41.4_300_3 　
16.NIDDMの予後とセルフケア行動および心理社会的要因の影響の検討(第49回日本心身医学会東北地方会演題抄録)

名倉洋子, 熊野宏昭, 中谷直樹, 朝倉徹, 檜尾好徳, 及川眞一, 豊田隆謙, 松本雅博, 相良幹雄, 柿崎正栄, 福土審

心身医学　41　(4)　301-301　2001年
出版者・発行元：一般社団法人日本心身医学会
DOI： 10.15064/jjpm.41.4_301_1 　
17.中学生の学校ストレス : 性差および学年差の検討(第48回日本心身医学会東北地方会演題抄録)

古口高志, 中谷直樹, 熊野宏昭, 山内祐一

心身医学　40　(6)　492-493　2000年
出版者・発行元：一般社団法人日本心身医学会
DOI： 10.15064/jjpm.40.6_492_4 　
IG-4 アローバランスグラフの信頼性の検討及び心理的質問表との関連性について(心理テストI)

中谷直樹, 熊野宏昭, 美野田啓二

心身医学　39　95-95　1999年
出版者・発行元：一般社団法人日本心身医学会
DOI： 10.15064/jjpm.39.supplementII_95_1 　
Partners’ ongoing treatment for chronic disease and the risk of psychological distress after the Great East Japan Earthquake. Nakaya N, Narita A, Tsuchiya N, Nakamura T, Tsuji I, Hozawa A, Tomita H. Tohoku Journal of Experimental Medicine (In press) 査読有り

︎全件表示 ︎最初の5件までを表示

MISC 320

ソルセイブによる塩味味覚閾値と高血圧有病の関連:東北メディカル・メガバンク計画地域住民コホート調査

平田朱音, 小暮真奈, 小暮真奈, 畑中里衣子, 畑中里衣子, 中谷久美, 中谷久美, 千葉一平, 千葉一平, 高瀬雅仁, 高瀬雅仁, 布施昇男, 布施昇男, 泉陽子, 中谷直樹, 中谷直樹, 寳澤篤, 寳澤篤

日本循環器病予防学会誌　60　(2)　2025年

ISSN： 1346-6267
高血圧の家族歴,遺伝要因,生活習慣の組み合わせと高血圧発症の関連:東北メディカル・メガバンク地域住民コホート調査

高瀬雅仁, 高瀬雅仁, 平田匠, 平田匠, 中谷直樹, 中谷直樹, 小暮真奈, 小暮真奈, 畑中里衣子, 畑中里衣子, 中谷久美, 中谷久美, 千葉一平, 千葉一平, 時岡紗由理, 時岡紗由理, 田宮元, 田宮元, 田宮元, 寳澤篤, 寳澤篤

日本循環器病予防学会誌　60　(2)　2025年

ISSN： 1346-6267
特定健康診査時にナトカリ計で複数年連続測定した尿ナトリウム/カリウム比と血圧の8年間の経年変化

小暮真奈, 千葉美香, 及川清美, 黒川悦子, 志賀利一, 清水友紀子, 鈴木重徳, 上田宏幸, 中谷直樹, 寳澤篤

日本循環器病予防学会誌　60　(2)　2025年

ISSN： 1346-6267
リアルワールドデータを用いたDPP-4阻害薬服薬者と非服薬者の腎予後の比較

橋本英明, 佐藤倫広, 村上任尚, 遠山真弥, 中山晋吾, 小原拓, 中谷直樹, 森建文, 寳澤篤

日本腎臓学会誌　66　(4)　616-616　2024年6月
出版者・発行元： (一社)日本腎臓学会
ISSN： 0385-2385

eISSN： 1884-0728
リアルワールドデータを用いたDPP-4阻害薬服薬者と非服薬者の腎予後の比較

橋本英明, 佐藤倫広, 村上任尚, 遠山真弥, 中山晋吾, 小原拓, 中谷直樹, 森建文, 寳澤篤

日本腎臓学会誌　66　(4)　616-616　2024年6月
出版者・発行元： (一社)日本腎臓学会
ISSN： 0385-2385

eISSN： 1884-0728
糖尿病の家族歴、遺伝要因、生活習慣の組み合わせと糖尿病発症の関連東北メディカル・メガバンク地域住民コホート調査

高瀬雅仁, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 時岡紗由理, 平田匠, 田宮元, 寳澤篤

日本循環器病予防学会誌　59　(2)　127-127　2024年4月
出版者・発行元： (一社)日本循環器病予防学会
ISSN： 1346-6267

eISSN： 2759-5323
家庭血圧と難聴の有無の関連東北メディカル・メガバンク地域住民コホート調査

佐竹芽久美, 千葉一平, 高瀬雅仁, 畑中里衣子, 中谷久美, 小暮真奈, 時岡紗由理, 中谷直樹, 寳澤篤

日本循環器病予防学会誌　59　(2)　128-128　2024年4月
出版者・発行元： (一社)日本循環器病予防学会
ISSN： 1346-6267

eISSN： 2759-5323
ToMMo地域住民コホート調査におけるPreserved ratio impaired spirometryの有病と出生体重の因果関係の検討

岩崎史, 中谷久美, 山田充啓, 中谷直樹, 小暮真奈, 畑中里衣子, 千葉一平, 寳澤篤, 杉浦久敏

日本呼吸器学会誌　13　(増刊)　255-255　2024年3月
出版者・発行元： (一社)日本呼吸器学会
ISSN： 2186-5876

eISSN： 2186-5884
一般成人集団における血中好酸球数分布と関連要因の探索 ToMMo地域住民コホート調査

鈴木眞奈美, 山田充啓, 中谷直樹, 小暮真奈, 千葉一平, 中谷久美, 畑中里衣子, 高瀬雅仁, 岩崎史, 寳澤篤, 杉浦久敏

日本呼吸器学会誌　13　(増刊)　255-255　2024年3月
出版者・発行元： (一社)日本呼吸器学会
ISSN： 2186-5876

eISSN： 2186-5884
The Association of Urinary Sodium-to-Potassium Ratio and Estimated Urinary Sodium Excretion with Atrial Fibrillation among Participants without Hypertension(タイトル和訳中)

時岡紗由理, 中谷直樹, 畑中里衣子, 中谷久美, 千葉一平, 小暮真奈, 後岡広太郎, 大類真嗣, 宇留野晃, 小林朋子, 児玉栄一, 濱中洋平, 布施昇男, 寳澤篤

日本循環器学会学術集会抄録集　88回　PJ005-4　2024年3月
出版者・発行元： (一社)日本循環器学会
リアルワールドデータを用いたDPP-4阻害薬服薬者と非服薬者の腎予後の比較

橋本英明, 佐藤倫広, 村上任尚, 遠山真弥, 中山晋吾, 小原拓, 中谷直樹, 森建文, 寳澤篤

日本腎臓学会誌(Web)　66　(4)　2024年

ISSN： 1884-0728
一般成人集団における血中好酸球数分布と関連要因の探索;ToMMo地域住民コホート調査

鈴木眞奈美, 山田充啓, 中谷直樹, 小暮真奈, 千葉一平, 中谷久美, 畑中里衣子, 高瀬雅仁, 岩崎史, 寳澤篤, 杉浦久敏

日本呼吸器学会誌(Web)　13　2024年

ISSN： 2186-5884
ToMMo地域住民コホート調査におけるPreserved ratio impaired spirometryの有病と出生体重の因果関係の検討

岩崎史, 中谷久美, 山田充啓, 中谷直樹, 小暮真奈, 畑中里衣子, 千葉一平, 寳澤篤, 杉浦久敏

日本呼吸器学会誌(Web)　13　2024年

ISSN： 2186-5884
精神障害のある方に対するがん検診及びがん診療のアクセシビリティの向上に資する研究行政機関の保有するデータを利用した精神障害者の住民がん検診受診率モニタリングの検討

稲垣正俊, 島津太一, 藤森麻衣子, 内富庸介, 藤原雅樹, 高木学, 山田裕士, 中谷直樹, 大朏孝治, 太田順一郎, 野口正行, 小原圭司, 名越究

精神障害のある方に対するがん検診及びがん診療のアクセシビリティの向上に資する研究令和5年度総括・分担研究報告書(Web)　2024年
精神障害のある方に対するがん検診及びがん診療のアクセシビリティの向上に資する研究精神障害のあるがん患者の治療を支援するためのプログラムの開発

稲垣正俊, 島津太一, 藤森麻衣子, 内富庸介, 藤原雅樹, 高木学, 山田裕士, 田端雅弘, 田村研治, 長濱道治, 中谷直樹, 大朏孝治, 江藤剛, 三牧好子, 山口恵, 井上尚子, 神崎あかね, 廣部貴惠

精神障害のある方に対するがん検診及びがん診療のアクセシビリティの向上に資する研究令和5年度総括・分担研究報告書(Web)　2024年
精神障害のある方に対するがん検診及びがん診療のアクセシビリティの向上に資する研究精神障害者に対するがん検診勧奨法の実装研究

稲垣正俊, 島津太一, 藤森麻衣子, 内富庸介, 藤原雅樹, 高木学, 山田裕士, 樋之津史郎, 山田了士, 堀井茂男, 小林孝文, 中谷直樹, 大朏孝治, 江藤剛

精神障害のある方に対するがん検診及びがん診療のアクセシビリティの向上に資する研究令和5年度総括・分担研究報告書(Web)　2024年
予後予測のための新規基礎疾患スコア

佐藤伊佐雄, 八田和久, 中谷久美, 中谷直樹, 尾形洋平, 齊藤真弘, 金笑奕, 宇野要, 小池智幸, 今谷晃, 中村智洋, 正宗淳, 寳澤篤

日本消化器病学会雑誌(Web)　121　2024年

ISSN： 1349-7693
“Na/K比′′を活用した宮城県内での新たな取り組みと今後の展望

小暮真奈, 小暮真奈, 中谷直樹, 中谷直樹, 寳澤篤, 寳澤篤

東北公衆衛生学会講演集　73rd (CD-ROM)　2024年

ISSN： 0915-549X
Life’s Essential8と要介護認定の関連:東北メディカル・メガバンク計画地域住民コホート調査

高瀬雅仁, 高瀬雅仁, 中谷直樹, 中谷直樹, 小暮真奈, 小暮真奈, 畑中里衣子, 畑中里衣子, 中谷久美, 中谷久美, 千葉一平, 千葉一平, 時岡紗由理, 時岡紗由理, 寳澤篤, 寳澤篤

東北公衆衛生学会講演集　73rd (CD-ROM)　2024年

ISSN： 0915-549X
Fitbitを用いた身体活動および睡眠状態の測定-進捗と測定値の特性-

千葉一平, 千葉一平, 中谷直樹, 中谷直樹, 小暮真奈, 小暮真奈, 中谷久美, 中谷久美, 畑中里衣子, 畑中里衣子, 高瀬雅仁, 高瀬雅仁, 時岡紗由理, 時岡紗由理, 小原拓, 小原拓, 小原拓, 永家聖, 永家聖, 荻島創一, 荻島創一, 荻島創一, 麦倉俊司, 麦倉俊司, 麦倉俊司, 布施昇男, 布施昇男, 布施昇男, 長神風二, 長神風二, 長神風二, 寳澤篤, 寳澤篤

日本公衆衛生学会総会抄録集(CD-ROM)　83rd　2024年
健康的な生活習慣と新型コロナウイルス感染・新型コロナワクチン接種の効果との関連

大類真嗣, 大類真嗣, 小原拓, 小原拓, 石黒真美, 石黒真美, 野田あおい, 野田あおい, 村上慶子, 中村智洋, 中村智洋, 中村智洋, 目時弘仁, 目時弘仁, 目時弘仁, 中谷直樹, 中谷直樹, 寳澤篤, 寳澤篤, 栗山進一, 栗山進一, 栗山進一

日本公衆衛生学会総会抄録集(CD-ROM)　83rd　2024年
東日本大震災直後の避難行動と関連する要因:東北メディカル・メガバンク計画地域住民コホート調査(宮城)

中谷直樹, 中谷直樹, 仲島瑠仁, 中谷久美, 中谷久美, 畑中里衣子, 畑中里衣子, 小暮真奈, 小暮真奈, 千葉一平, 千葉一平, 時岡紗由理, 時岡紗由理, 高瀬雅仁, 高瀬雅仁, 栗山進一, 栗山進一, 栗山進一, 寳澤篤, 寳澤篤

東北公衆衛生学会講演集　73rd (CD-ROM)　2024年

ISSN： 0915-549X
ToMMo地域住民コホートにおける閉塞性換気障害の有病と関連要因,生命予後の検討

岩崎史, 山田充啓, 中谷久美, 中谷直樹, 中村智洋, 中村智洋, 永家聖, 荻島創一, 小原拓, 布施昇男, 泉陽子, 栗山進一, 栗山進一, 杉浦久敏, 寶澤篤

日本公衆衛生学会総会抄録集(CD-ROM)　83rd　2024年
家庭血圧に対するゲノムワイド関連解析

高瀬雅仁, 高瀬雅仁, 中谷直樹, 中谷直樹, 小暮真奈, 小暮真奈, 畑中里衣子, 畑中里衣子, 中谷久美, 中谷久美, 千葉一平, 千葉一平, 時岡紗由理, 時岡紗由理, 田宮元, 田宮元, 田宮元, 寳澤篤, 寳澤篤

日本高血圧学会総会プログラム・抄録集(CD-ROM)　46th　2024年
等価世帯収入と新型コロナウイルス流行期および流行後の高血圧患者の定期受診状況の関連

遠山真弥, 遠山真弥, 佐藤倫広, 佐藤倫広, 佐藤倫広, 中山晋吾, 中山晋吾, 村上任尚, 村上任尚, 中谷直樹, 目時弘仁, 寳澤篤, 寳澤篤

日本高血圧学会総会プログラム・抄録集(CD-ROM)　46th　2024年
尿中Na、K、Na/K比と胃がん罹患との関連東北メディカル・メガバンク計画地域住民コホート調査

小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 小原拓, 永家聖, 布施昇男, 泉陽子, 栗山進一, 中谷直樹, 寳澤篤

Journal of Epidemiology　34　(Suppl.)　100-100　2024年1月
出版者・発行元： (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
尿中ナトリウム/カリウム比と心房細動の関連の検討

時岡紗由理, 中谷直樹, 畑中里衣子, 千葉一平, 中谷久美, 小暮真奈, 大類正嗣, 宇留野晃, 小林朋子, 児玉栄一, 濱中洋平, 布施昇男, 寳澤篤

Journal of Epidemiology　34　(Suppl.)　122-122　2024年1月
出版者・発行元： (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
身長と食塩摂取量の組み合わせと収縮期血圧の関連:東北メディカル・メガバンク計画地域住民コホート調査

小久保璃奈, 高瀬雅仁, 高瀬雅仁, 小暮真奈, 小暮真奈, 畑中里衣子, 畑中里衣子, 中谷久美, 中谷久美, 千葉一平, 千葉一平, 時岡紗由理, 時岡紗由理, 中谷直樹, 中谷直樹, 寳澤篤, 寳澤篤

日本高血圧学会総会プログラム・抄録集(CD-ROM)　46th　(Suppl.)　133-133　2024年1月
出版者・発行元： (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
ToMMo地域住民コホート調査におけるPreserved ratio impairment spirometryの有病と関連する要因の検討

岩崎史, 中谷久美, 山田充啓, 中谷直樹, 小暮真奈, 畑中里衣子, 千葉一平, 菅野郁美, 小原拓, 石黒真美, 大類真嗣, 永家聖, 中村智洋, 荻島創一, 布施昇男, 泉陽子, 栗山進一, 杉浦久敏, 寳澤篤

Journal of Epidemiology　34　(Suppl.)　139-139　2024年1月
出版者・発行元： (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
Alcohol Flushingと悪性腫瘍有病の関連 TMM計画地域住民コホート調査(宮城)

土谷祐馬, 中谷久美, 中谷直樹, 小暮真奈, 畑中里衣子, 千葉一平, 菅野郁美, 小原拓, 石黒真美, 大類正嗣, 永家聖, 中村智洋, 荻島創一, 布施昇男, 泉陽子, 栗山進一, 亀井尚, 寳澤篤

Journal of Epidemiology　34　(Suppl.)　154-154　2024年1月
出版者・発行元： (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
産後うつ・自殺問題の縦断的リスクと関連要因の検討東北メディカル・メガバンク計画三世代コホート調査

大類真嗣, 小原拓, 石黒真美, 野田あおい, 篠田元気, 村上慶子, 岩間憲之, 千葉一平, 中谷久美, 畑中里衣子, 小暮真奈, 目時弘仁, 菊谷昌浩, 中谷直樹, 寳澤篤, 栗山進一

Journal of Epidemiology　34　(Suppl.)　158-158　2024年1月
出版者・発行元： (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
震災による自宅損壊および心的外傷後ストレス反応と修正可能な認知症の危険因子の関連

千葉一平, 小暮真奈, 中谷久美, 畑中里衣子, 小原拓, 丹野高三, 栗山進一, 中谷直樹, 寳澤篤

Journal of Epidemiology　34　(Suppl.)　174-174　2024年1月
出版者・発行元： (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
遺伝要因、生活習慣の組み合わせと糖尿病発症の関連東北メディカル・メガバンク地域住民コホート調査

高瀬雅仁, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 中村智洋, 後岡広太郎, 土屋菜歩, 平田匠, 松田浩一, 栗山進一, 木下賢吾, 田宮元, 寳澤篤

Journal of Epidemiology　34　(Suppl.)　176-176　2024年1月
出版者・発行元： (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
【がんと不眠】睡眠とがんに関する疫学研究

相原彩香, 中谷久美, 中谷直樹

Progress in Medicine　43　(10)　885-889　2023年10月
出版者・発行元： (株)ライフ・サイエンス
ISSN： 0287-3648
脂肪量指数と除脂肪量指数の組み合わせと高LDLコレステロール血症の関連

高瀬雅仁, 中村智洋, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 後岡広太郎, 土屋菜歩, 平田匠, 栗山進一, 寳澤篤

日本公衆衛生学会総会抄録集　82回　272-272　2023年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災による家屋損壊の程度と要支援・要介護認定・死亡リスクとの関連

滑川千慧, 小暮真奈, 菅野郁美, 畑中里衣子, 中谷久美, 千葉一平, 平田匠, 宇留野晃, 布施昇男, 中谷直樹, 栗山進一, 寳澤篤

日本公衆衛生学会総会抄録集　82回　286-286　2023年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東北メディカル・メガバンク計画三世代コホート調査これまでの進捗

大類真嗣, 小原拓, 石黒真美, 野田あおい, 篠田元気, 村上慶子, 菅野郁美, 千葉一平, 中谷久美, 畑中里衣子, 小暮真奈, 中谷直樹, 寶澤篤, 栗山進一

日本公衆衛生学会総会抄録集　82回　370-370　2023年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東北メディカル・メガバンク計画三世代コホート調査における追加リクルート

石黒真美, 小原拓, 野田あおい, 篠田元気, 大類真嗣, 村上慶子, 菅野郁美, 千葉一平, 中谷久美, 畑中里衣子, 小暮真奈, 中谷直樹, 寳澤篤, 栗山進一

日本公衆衛生学会総会抄録集　82回　370-370　2023年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
コホート調査データの連係・活用推進のための基盤整備マイToMMoの開発と実装

野田あおい, 篠田元気, 石黒真美, 千葉一平, 大類真嗣, 村上慶子, 小原拓, 菅野郁美, 中谷久美, 畑中里衣子, 小暮真奈, 中谷直樹, 寳澤篤, 栗山進一

日本公衆衛生学会総会抄録集　82回　371-371　2023年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東北メディカル・メガバンク計画地域住民コホート調査(宮城) これまでの進捗

中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 石黒真美, 大類真嗣, 野田あおい, 篠田元気, 村上慶子, 小原拓, 栗山進一, 寳澤篤

日本公衆衛生学会総会抄録集　82回　398-398　2023年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連東北メディカル・メガバンク地域住民コホート調査

高瀬雅仁, 平田匠, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 目時弘仁, 佐藤倫広, 小原拓, 栗山進一, 田宮元, 寳澤篤

日本高血圧学会総会プログラム・抄録集　45回　261-261　2023年9月
出版者・発行元： (NPO)日本高血圧学会
高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連東北メディカル・メガバンク地域住民コホート調査

高瀬雅仁, 平田匠, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 目時弘仁, 佐藤倫広, 小原拓, 栗山進一, 田宮元, 寳澤篤

日本高血圧学会総会プログラム・抄録集　45回　358-358　2023年9月
出版者・発行元： (NPO)日本高血圧学会
産後女性のうつ・自殺関連問題の縦断的リスク評価の記述的分析東北メディカル・メガバンク計画三世代コホート調査

大類真嗣, 小原拓, 石黒真美, 野田あおい, 篠田元気, 千葉一平, 中谷久美, 畑中里衣子, 小暮真奈, 中谷直樹, 寳澤篤, 栗山進一

東北公衆衛生学会誌　(72)　25-25　2023年7月
出版者・発行元：東北公衆衛生学会
ISSN： 0915-549X
体組成と身体学的バイオマーカーの関連東北メディカル・メガバンク計画地域住民コホート調査

高瀬雅仁, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 寳澤篤

東北公衆衛生学会誌　(72)　34-34　2023年7月
出版者・発行元：東北公衆衛生学会
ISSN： 0915-549X
自宅から近隣施設までの距離と各種検査データとの関連地理情報システム(GIS)を用いた検討

畑中里衣子, 小暮真奈, 中谷久美, 千葉一平, 菅野郁美, 中谷直樹, 寳澤篤

東北公衆衛生学会誌　(72)　38-38　2023年7月
出版者・発行元：東北公衆衛生学会
ISSN： 0915-549X
特定健診会場で測定した尿Na/K比が与える血圧への影響 3年間のNDBオープンデータとの比較

小暮真奈, 及川満代, 黒川悦子, 永吉翔, 志賀利一, 牛田悠介, 上田宏幸, 本間洋子, 中谷直樹, 寳澤篤

日本循環器病予防学会誌　58　(2)　155-155　2023年5月
出版者・発行元： (一社)日本循環器病予防学会
ISSN： 1346-6267
背景因子とAIS得点を考慮したCES-D陽性の推定有病率の可視化

松山崇, 成田暁, 高梨昌樹, 小暮真奈, 佐藤守一, 中村智洋, 中根英雄, 荻島創一, 長神風二, 中谷直樹, 丹野高三, 今枝孝夫, 寳澤篤

Journal of Epidemiology　33　(Suppl.1)　118-118　2023年2月
出版者・発行元： (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
東北メディカル・メガバンク計画三世代コホート調査の進捗と今後の計画

石黒真美, 小原拓, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 松崎芙実子, 目時弘仁, 菊谷昌浩, 菅原準一, 中谷直樹, 寳澤篤, 栗山進一

Journal of Epidemiology　33　(Suppl.1)　117-117　2023年2月
出版者・発行元： (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
大規模観察研究におけるランダム男女ペア間の循環代謝リスク因子の類似性の検討

中谷直樹, 中谷久美, 土屋菜歩, 曽根稔雅, 小暮真奈, 畑中里衣子, 菅野郁美, 目時弘仁, 小原拓, 石黒真美, 寳澤篤, 栗山進一

Journal of Epidemiology　33　(Suppl.1)　173-173　2023年2月
出版者・発行元： (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
夫婦の生活習慣・生活習慣病の一致度,介入戦略

中谷直樹, 中谷直樹

日本サイコオンコロジー学会総会(Web)　36th　2023年
東北メディカル・メガバンク計画三世代コホート調査概要と進捗

小原拓, 石黒真美, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 松崎芙実子, 中谷直樹, 寳澤篤, 菅原準一, 栗山進一

DOHaD研究　10　(2)　80-80　2022年10月
出版者・発行元： (一社)日本DOHaD学会
ISSN： 2187-2562

eISSN： 2187-2597
正常高値血圧、高値血圧における中心血圧、頸動脈内膜中膜厚と新規高血圧発症の関連

時岡紗由理, 中谷直樹, 中谷久美, 高瀬雅仁, 小暮真奈, 畑中里衣子, 菅野郁美, 千葉一平, 目時弘仁, 村上任尚, 佐藤倫広, 小原拓, 栗山進一, 寳澤篤

日本高血圧学会総会プログラム・抄録集　44回　80-80　2022年10月
出版者・発行元： (NPO)日本高血圧学会
年齢と骨梁面積率との関連年齢階級別の検討 ToMMo地域住民コホート調査

菅野郁美, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 中村智洋, 小原拓, 目時弘仁, 布施昇男, 栗山進一, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　81回　203-203　2022年9月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
心血管・代謝疾患リスク要因における配偶者同士の類似性 2ヵ国バイオバンク横断研究

中谷直樹, 土屋菜歩, 成田暁, 中村智洋, 目時弘仁, 小原拓, 石黒真美, 寳澤篤, 栗山進一

日本公衆衛生学会総会抄録集　81回　204-204　2022年9月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
尿ナトリウム/カリウム比と脳性ナトリウム利尿ペプチド大迫研究

室谷智子, 佐藤倫広, 村上任尚, 中山晋吾, 廣瀬卓男, 橋本英明, 遠山真弥, 高畠恭介, 辰巳友佳子, 井上隆輔, 坪田恵[宇津木], 小暮真奈, 中谷直樹, 浅山敬, 野村恭子, 菊谷昌浩, 目時弘仁, 今井潤, 寳澤篤, 大久保孝義

東北公衆衛生学会誌　(71)　29-30　2022年7月
出版者・発行元：東北公衆衛生学会
ISSN： 0915-549X
東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の進捗

中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 小原拓, 中村智洋, 宇留野晃, 布施昇男, 泉陽子, 丹野高三, 辻一郎, 栗山進一, 寳澤篤

東北公衆衛生学会誌　(71)　28-28　2022年7月
出版者・発行元：東北公衆衛生学会
ISSN： 0915-549X
統合失調症患者に対するがん検診勧奨法の質的評価混合研究法を用いた無作為化比較試験の二次解析

山田裕士, 藤原雅樹, 島津太一, 江藤剛, 児玉匡史, 宋龍平, 松下貴紀, 吉村優作, 堀井茂男, 藤森麻衣子, 高橋宏和, 中谷直樹, 宮路天平, 樋之津史郎, 原田馨太, 岡田裕之, 内富庸介, 山田了士, 稲垣正俊

精神神経学雑誌　124　(4付録)　S-373　2022年4月
出版者・発行元： (公社)日本精神神経学会
ISSN： 0033-2658
精神科臨床場面における多職種協働によるがん検診の受診勧奨法のランダム化比較試験

藤原雅樹, 山田裕士, 島津太一, 児玉匡史, 宋龍平, 松下貴紀, 吉村優作, 堀井茂男, 藤森麻衣子, 高橋宏和, 中谷直樹, 掛田恭子, 宮路天平, 樋之津史郎, 原田馨太, 岡田裕之, 内富庸介, 山田了士, 稲垣正俊

精神神経学雑誌　124　(4付録)　S-643　2022年4月
出版者・発行元： (公社)日本精神神経学会
ISSN： 0033-2658
精神障害者のがん診療における課題:精神科医療従事者に対する質問紙調査

山田裕士, 江藤剛, 藤原雅樹, 和田里穂, 井上真一郎, 三牧好子, 児玉匡史, 松下貴紀, 吉村優作, 堀井茂男, 藤森麻衣子, 島津太一, 中谷直樹, 樋之津史郎, 田村研治, 田端雅弘, 内富庸介, 山田了士, 稲垣正俊

日本サイコオンコロジー学会総会(Web)　35th　2022年
地域および職域の健康診査に尿Na/K比測定を導入して見えてきたこと健診機関とのタイアップ

小暮真奈, 佐々木久美子, 畑中里衣子, 菅野郁美, 板橋芙美, 黒川悦子, 大川亜美, 宮川健, 永吉翔, 牛田悠介, 清水友紀子, 上田宏幸, 土屋菜歩, 中谷直樹, 寳澤篤

総合健診　49　(1)　205-205　2022年1月
出版者・発行元： (一社)日本総合健診医学会
ISSN： 1347-0086

eISSN： 1884-4103
東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の概要

中谷直樹, 小暮真奈, 畑中里衣子, 菅野郁美, 中谷久美, 小原拓, 中村智洋, 宇留野晃, 布施昇男, 泉陽子, 丹野高三, 辻一郎, 栗山進一, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　80回　219-219　2021年11月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
統合失調症患者における日本語版WHODAS 2.0 12項目自己記入版の妥当性、信頼性の検討

和田里穂, 藤原雅樹, 山田裕士, 中谷直樹, 藤森麻衣子, 宋龍平, 児玉匡史, 樋口裕二, 掛田恭子, 内富庸介, 山田了士, 稲垣正俊

総合病院精神医学　33　(Suppl.)　S-165　2021年11月
出版者・発行元： (一社)日本総合病院精神医学会
ISSN： 0915-5872
特定健康診査時に尿ナトカリ計で4年連続測定した尿ナトリウム/カリウム比の変化と血圧への影響 COI東北拠点と宮城県登米市の共同研究

小暮真奈, 須藤庸子, 及川満代, 土屋菜歩, 平田匠, 畑中里衣子, 佐々木久美子, 黒川悦子, 宮川健, 牛田悠介, 上田宏幸, 佐々木秀美, 本間洋子, 中谷直樹, 寳澤篤

日本高血圧学会総会プログラム・抄録集　43回　261-261　2021年10月
出版者・発行元： (NPO)日本高血圧学会
東日本大震災に伴う災害による健康影響に関する文献レビュー

高瀬雅仁, 五十嵐有香, 中谷直樹, 小暮真奈, 畑中里衣子, 菅野郁美, 中谷久美, 中村智洋, 後岡広太郎, 後岡広太郎, 寳澤篤

日本循環器病予防学会誌　56　(3)　2021年

ISSN： 1346-6267
精神障害者のがん診療における課題の定量:がん医療従事者に対する質問紙調査

山田裕士, 藤原雅樹, 江藤剛, 和田里穂, 井上真一郎, 児玉匡史, 松下貴紀, 吉村優作, 堀井茂男, 藤森麻衣子, 掛田恭子, 島津太一, 中谷直樹, 田村研治, 田端雅弘, 内富庸介, 山田了士, 稲垣正俊

日本サイコオンコロジー学会総会(Web)　34th　2021年
精神障害者に対するがん診療の課題:がん医療従事者と精神科医療従事者に対する質問紙調査の質的分析

江藤剛, 藤原雅樹, 山田裕士, 和田里穂, 樋口裕二, 井上真一郎, 児玉匡史, 松下貴紀, 吉村優作, 堀井茂男, 藤森麻衣子, 掛田恭子, 島津太一, 中谷直樹, 田端雅弘, 内富庸介, 山田了士, 稲垣正俊

日本サイコオンコロジー学会総会(Web)　34th　2021年
がん罹患者の配偶者の死亡リスク:大崎コホート2006

中谷直樹, 中谷直樹, 曽根稔雅, 遠又靖丈, 遠又靖丈, 中谷久美, 中谷久美, 星真行, 清水研, 辻一郎, 辻一郎

日本疫学会学術総会講演集(Web)　30th　2020年
「精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築」精神障害者のがん診断と治療における課題を明らかにし,問題を解決するための連携を促進する体制構築を目指す研究

稲垣正俊, 山田了士, 内富庸介, 藤森麻衣子, 藤原雅樹, 堀井茂男, 児玉匡史, 島津太一, 高橋宏和, 中谷直樹, 森田達也, 松下貴紀, 吉村優作, 宋龍平, 掛田恭子, 樋口裕二, 山田裕士, 井上真一郎, 和田里穂, 江藤剛

精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築令和元年度総括・分担研究報告書(Web)　2020年
「精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築」精神科臨床場面における多職種協働による効果的ながん検診の受診勧奨法の開発と効果を検証する研究

稲垣正俊, 山田了士, 内富庸介, 藤森麻衣子, 樋之津史郎, 藤原雅樹, 堀井茂男, 児玉匡史, 宮路天平, 島津太一, 高橋宏和, 中谷直樹, 森田達也, 松下貴紀, 吉村優作, 宋龍平, 掛田恭子, 樋口裕二, 山田裕士, 岡田裕之, 原田馨太, 黒崎美雪

精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築令和元年度総括・分担研究報告書(Web)　2020年
家庭での受動喫煙および能動喫煙の組み合わせと高血圧の関連

平田匠, 小暮真奈, 成田暁, 土屋菜歩, 中村智洋, 目時弘仁, 中谷直樹, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　78回　223-223　2019年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
配偶者同士の生活習慣の一致性とその年齢の影響 ToMMo 地域住民コホート調査

中谷直樹, 土屋菜歩, 成田暁, 石黒真美, 目時弘仁, 平田匠, 小暮真奈, 中村智洋, 後岡広太郎, 中谷久美, 辻一郎, 呉繁夫, 栗山進一, 寳澤篤

日本公衆衛生学会総会抄録集　78回　224-224　2019年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災が沿岸地域の就労と精神的健康に及ぼした影響

片柳光昭, 富田博秋, 瀬戸萌, 根本晴美, 奥山純子, 鈴木智美, 菅原由美, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 小高晃, 辻一郎, 寳澤篤

精神神経学雑誌　115th　(2019特別号)　S753-S753　2019年6月
出版者・発行元： (公社)日本精神神経学会
ISSN： 0033-2658
精神科病院に通院中の統合失調症患者の禁煙ステージとその後の禁煙行動アンケートによる縦断調査

藤原雅樹, 樋口裕二, 稲垣正俊, 中谷直樹, 藤森麻衣子, 林原千夏, 宋龍平, 新川郁太, 佐藤康治郎, 矢田勇慈, 児玉匡史, 竹中央, 来住由樹, 掛田恭子, 内富庸介, 山田了士

精神神経学雑誌　(2019特別号)　S436-S436　2019年6月
出版者・発行元： (公社)日本精神神経学会
ISSN： 0033-2658
一般地域住民における血清クレアチニンによる推定糸球体濾過量(eGFR)の季節差

良知弘務, 土屋菜歩, 平田匠, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 栗山進一, 菅原準一, 呉繁夫, 宮崎真理子, 寳澤篤

日本腎臓学会誌　61　(3)　332-332　2019年5月
出版者・発行元： (一社)日本腎臓学会
ISSN： 0385-2385
東北メディカル・メガバンク計画地域住民コホート進捗と今後の展望

寳澤篤, 丹野高三, 中谷直樹, 平田匠, 瀧靖之, 栗山進一, 菅原準一, 坂田清美, 辻一郎, 呉繁夫

日本老年医学会雑誌　56　(Suppl.)　106-106　2019年5月
出版者・発行元： (一社)日本老年医学会
ISSN： 0300-9173
尿ナトリウム/カリウム比を健診に追加することで高血圧のPAFが12%増加し約50%に:COI東北拠点と登米市の共同研究

小暮真奈, 小暮真奈, 須藤庸子, 中村智洋, 中村智洋, 土屋菜歩, 土屋菜歩, 平田匠, 平田匠, 成田暁, 成田暁, 宮川健, 宮川健, 中谷直樹, 中谷直樹, 佐々木秀美, 寳澤篤, 寳澤篤

日本循環器病予防学会誌　54　(2)　122　2019年4月11日

ISSN： 1346-6267
新規リスク因子(尿ナトカリ比高値・睡眠効率不良)の高血圧への集団寄与危険割合の検討

平田匠, 中村智洋, 小暮真奈, 宮川健, 小原拓, 中谷直樹, 宇留野晃, 菅原準一, 栗山進一, 寳澤篤

日本循環器病予防学会誌　54　(2)　121-121　2019年4月
出版者・発行元： (一社)日本循環器病予防学会
ISSN： 1346-6267
非肥満者において肝機能指標の組み合わせと糖尿病の関連は飲酒により異なるか

一迫芙美, 平田匠, 土屋菜歩, 中村智洋, 成田暁, 小暮真奈, 中谷直樹, 栗山進一, 呉繁夫, 寳澤篤

日本循環器病予防学会誌　54　(2)　115-115　2019年4月
出版者・発行元： (一社)日本循環器病予防学会
ISSN： 1346-6267
東北メディカル・メガバンク計画地域住民コホート調査における糖尿病研究

平田匠, 寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐藤衛, 菊谷昌浩, 石垣泰, 坂田清美, 菅原準一, 栗山進一, 辻一郎, 呉繁夫

糖尿病　62　(Suppl.1)　S-304　2019年4月
出版者・発行元： (一社)日本糖尿病学会
ISSN： 0021-437X
東日本大震災による津波避難訓練の有効性

中谷直樹, 根本晴美, YI Carine J, 佐藤文子, 新宮古都美, 庄子朋香, 佐藤翔輔, 土屋菜歩, 中村智洋, 成田暁, 小暮真奈, 菅原由美, 兪志前, GUNAWANSA Nicole, 栗山進一, 村尾修, 佐藤健, 今村文彦, 富田博秋

宮城県公衆衛生学会会誌　(51)　12　2019年3月

ISSN： 0912-747X
未治療高血圧者に対する平成29年度特定健康診査時の尿ナトカリ比及び保健指導後の医療受診動向について

鈴木智美, 鈴木智美, 板橋由紀, 小暮真奈, 堀籠千賀, 中谷直樹, 中村智洋, 土屋菜歩, 平田匠, 成田暁, 渡邊真孝, 小野誠司, 渡辺文昭, 寳澤篤

宮城県公衆衛生学会会誌　(51)　13-13　2019年3月
出版者・発行元：宮城県公衆衛生学会
ISSN： 0912-747X
東北メディカル・メガバンク機構地域住民コホート調査詳細二次調査

寳澤篤, 中谷直樹, 土屋菜歩, 中村智洋, 平田匠, 成田暁, 小暮真奈, 栗山進一, 菅原準一, 呉繁夫

宮城県公衆衛生学会会誌　(51)　17-17　2019年3月
出版者・発行元：宮城県公衆衛生学会
ISSN： 0912-747X
東日本大震災による家屋損壊程度と過敏性腸症候群の関連

永家聖, 中谷直樹, 田中由佳里, 金澤素, 荻島創一, 高井貴子, 中村智洋, 土屋菜歩, 平田匠, 成田暁, 小暮真奈, 栗山進一, 田中博, 辻一郎, 呉繁夫, 寳澤篤, 福土審

日本疫学会学術総会講演集(Web)　29th　149 (WEB ONLY)　2019年1月30日
配偶者の主観的健康観と自身の抑うつ症状との関連:東北メディカル・メガバンク計画・地域住民コホート調査

中谷直樹, 土屋菜歩, 中谷久美, 成田暁, 平田匠, 中村智洋, 小暮真奈, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　29th　122 (WEB ONLY)　2019年1月30日
非肥満者における肝機能指標の組み合わせと糖尿病の関連

一迫芙美, 平田匠, 土屋菜歩, 中村智洋, 成田暁, 小暮真奈, 中谷直樹, 栗山進一, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　29th　151 (WEB ONLY)　2019年1月30日
夫婦間のメタボリック症候群及び構成因子の共有度:東北メディカル・メガバンク計画―地域住民コホート調査

土屋菜歩, 橋本航, 中谷直樹, 中村智洋, 平田匠, 成田暁, 小暮真奈, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　29th　154 (WEB ONLY)　2019年1月30日
遺伝因子と飲酒量の交互作用と随時血圧値の関連―東北メディカル・メガバンク計画地域住民コホート調査―

成田暁, 中谷直樹, 小暮真奈, 田宮元, 中村智洋, 土屋菜歩, 平田匠, 丹野高三, 坂田清美, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　29th　147 (WEB ONLY)　2019年1月30日
日本がん支持療法研究グループJapan Supportive,Palliative and Psychosocial Oncology Group(J-SUPPORT)の取り組みと実績:2016-2019

華井明子, 全田貞幹, 松岡豊, 山口拓洋, 安部正和, 島津太一, 中谷直樹, 藤森麻衣子, 松本禎久, 宮路天平, 内富庸介

日本がんサポーティブケア学会学術集会プログラム・抄録集　4th　2019年
精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築精神障害者のがん診断と治療における課題を明らかにし,問題を解決するための連携を促進する体制構築を目指す研究

稲垣正俊, 山田了士, 内富庸介, 藤森麻衣子, 藤原雅樹, 堀井茂男, 児玉匡史, 島津太一, 高橋宏和, 中谷直樹, 森田達也, 松下貴紀, 吉村優作, 宋龍平, 掛田恭子, 樋口裕二, 山田裕士, 井上真一郎

精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築平成30年度総括・分担研究報告書(Web)　2019年
精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築精神科臨床場面における多職種協働による効果的ながん検診の受診勧奨法の開発と効果を検証する研究

稲垣正俊, 山田了士, 内富庸介, 藤森麻衣子, 樋之津史郎, 藤原雅樹, 堀井茂男, 児玉匡史, 島津太一, 高橋宏和, 中谷直樹, 宮路天平, 森田達也, 松下貴紀, 吉村優作, 宋龍平, 掛田恭子, 樋口裕二, 山田裕士, 岡田裕之, 原田馨太

精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築平成30年度総括・分担研究報告書(Web)　2019年
東日本大震災の被災地住民における平均歩数の変化地域住民コホート調査

中谷直樹, 中村智洋, 土屋菜歩, 平田匠, 成田暁, 小暮真奈, 後岡広太郎, 丹野高三, 坂田清美, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　77回　209-209　2018年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
尿中ナトリウムカリウム比値と家庭血圧値の変化地域住民コホート調査

小暮真奈, 中谷直樹, 土屋菜歩, 中村智洋, 平田匠, 成田暁, 後岡広太郎, 丹野高三, 坂田清美, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　77回　215-215　2018年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災の被災地住民における家庭血圧値の変化地域住民コホート調査

中村智洋, 中谷直樹, 土屋菜歩, 平田匠, 成田暁, 小暮真奈, 後岡広太郎, 丹野高三, 坂田清美, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　77回　218-218　2018年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災後のメンタルヘルス関連指標変化と家屋被害の関連

土屋菜歩, 中村智洋, 平田匠, 成田暁, 小暮真奈, 丹野高三, 坂田清美, 小原拓, 中谷直樹, 栗山進一, 辻一郎, 呉繁夫, 大塚耕太郎, 富田博秋, 寳澤篤

日本公衆衛生学会総会抄録集　77回　252-252　2018年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
家屋損壊程度と骨梁面積率の変化量の関連東北メディカル・メガバンク事業

成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 平田匠, 小暮真奈, 後岡広太郎, 丹野高三, 坂田清美, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　77回　253-253　2018年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
家屋の損壊の程度と頸動脈エコー内膜中膜肥厚の変化地域住民コホート調査

寳澤篤, 中谷久美, 平田匠, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 後岡広太郎, 丹野高三, 坂田清美, 小原拓, 中谷直樹, 栗山進一, 辻一郎, 呉繁夫

日本公衆衛生学会総会抄録集　77回　345-345　2018年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
一般住民における尿Na/K比と腎機能障害への進行の関連住民コホート調査

良知弘務, 土屋菜歩, 平田匠, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 小原拓, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　77回　345-345　2018年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災に伴う家屋被害の程度とHbA1c値の変化の関連地域住民コホート調査

平田匠, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 後岡広太郎, 丹野高三, 坂田清美, 小原拓, 中谷直樹, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　77回　358-358　2018年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
単日および複数日測定による尿ナトカリ比値と高血圧有病率との関連東北メディカル・メガバンク計画コホート調査の成果から

小暮真奈, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 宮川健, 栗山進一, 菅原準一, 菊谷昌浩, 寳澤篤

日本循環器病予防学会誌　53　(2)　181-181　2018年5月
出版者・発行元： (一社)日本循環器病予防学会
ISSN： 1346-6267
特定保健指導前後のナトリウムカリウム比変化と家庭血圧値変化との関連東北大学COI拠点と七ヶ浜町の共同研究

小暮真奈, 宮川健, 板橋由紀, 鈴木智美, 土屋菜歩, 中村智洋, 中谷直樹, 青木ゆかり, 阿部真也, 安田純, 寳澤篤

宮城県公衆衛生学会会誌　(50)　20-20　2018年3月
出版者・発行元：宮城県公衆衛生学会
ISSN： 0912-747X
サンプル間の非独立性が関連解析に及ぼす影響の予備的検討

成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 田宮元, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　28th　134 (WEB ONLY)　2018年2月1日
東日本大震災後の夫婦における生活習慣の共有度についての検討

土屋菜歩, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　28th　77 (WEB ONLY)　2018年2月1日
日本茶摂取頻度と頸動脈内膜中膜肥厚の関連

寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 木皿楓子, 丹野高三, 菊谷昌浩, 高井貴子, 菅原準一, 栗山進一, 辻一郎, 呉繁夫

日本疫学会学術総会講演集(Web)　28th　116 (WEB ONLY)　2018年2月1日
東日本大震災の被災者における高い平均歩数と関連する要因:地域住民コホート調査

中谷直樹, 成田暁, 土屋菜歩, 中村智洋, 小暮真奈, 丹野高三, 坂田清美, 菊谷昌弘, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　28th　137 (WEB ONLY)　2018年2月1日
東日本大震災による家屋損壊の程度とメタボリック症候群の構成要素

中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　28th　137 (WEB ONLY)　2018年2月1日
統合失調症患者の住民がん検診受診率市の検診受診記録を用いた単施設横断研究

藤原雅樹, 稲垣正俊, 中谷直樹, 樋口裕二, 藤森麻衣子, 林原千夏, 宋龍平, 掛田恭子, 児玉匡史, 内富庸介, 山田了士

日本サイコオンコロジー学会総会・日本臨床死生学会総会合同大会プログラム・抄録集　30回・23回　218-218　2017年10月
出版者・発行元： (一社)日本サイコオンコロジー学会・日本臨床死生学会
東日本大震災被災地における運動習慣の状況 TMM CommCohort Study

高梨信之, 丹野高三, 佐々木亮平, 坪田恵, 坂田清美, 寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 栗山進一, 辻一郎, 中村元行, 人見次郎

日本公衆衛生学会総会抄録集　76回　603-603　2017年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災被災地における社会的孤立の状況 TMM CommCohort Study

佐々木亮平, 丹野高三, 高梨信之, 坪田恵, 宇津木, 坂田清美, 寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 栗山進一, 辻一郎, 中村元行, 人見次郎

日本公衆衛生学会総会抄録集　76回　603-603　2017年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東北メディカル・メガバンク計画地域住民コホート調査における参加者のAQについて

山中千鶴, 中谷直樹, 成田暁, 中村智洋, 土屋菜歩, 小暮真奈, 菊谷昌浩, 石黒真美, 菅原準一, 辻一郎, 呉繁夫, 寳澤篤, 栗山進一

日本公衆衛生学会総会抄録集　76回　285-285　2017年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東北メディカル・メガバンク計画における地域住民コホート調査の詳細二次調査の概要

寳澤篤, 丹野高三, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 菊谷昌浩, 目時弘仁, 坂田清美, 菅原準一, 栗山進一, 辻一郎, 中村元行, 呉繁夫

日本公衆衛生学会総会抄録集　76回　287-287　2017年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災後の地域住民における腎機能と関連因子

土屋菜歩, 清元秀泰, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 菊谷昌浩, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　76回　290-290　2017年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
尿中ナトリウムカリウム比と高血圧有病リスクとの関連地域住民コホート調査

小暮真奈, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 清元秀泰, 菊谷昌浩, 目時弘仁, 小原拓, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　76回　291-291　2017年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災後の家屋損壊程度と体脂肪率の関連地域住民コホート調査

中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 坂田清美, 菊谷昌浩, 高井貴子, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　76回　292-292　2017年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
地域住民コホート調査における年齢別の中心血圧分布

菊谷昌浩, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 目時弘仁, 小原拓, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　76回　293-293　2017年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
頸動脈IMTとリスク因子の関連東北メディカル・メガバンク計画地域住民コホート調査

木皿楓子, 土屋菜歩, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 高井貴子, 菊谷昌浩, 目時弘仁, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　76回　293-293　2017年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
性・年齢階級別にみた家族との同居状況と心理的苦痛の関連地域住民コホート調査

及川真紀, 佐藤喜根子, 佐藤眞理, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 富田博秋, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　76回　315-315　2017年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
地域住民コホート調査における家屋の被害の程度と平均歩数の関連

中谷直樹, 成田暁, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 坂田清美, 菊谷昌浩, 高井貴子, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　76回　325-325　2017年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東北メディカル・メガバンクにおける過敏性腸症候群の有病割合地域住民コホート調査

永家聖, 中谷直樹, 田中由佳里, 金澤素, 荻島創一, 高井貴子, 中村智洋, 土屋菜歩, 成田暁, 栗山進一, 田中博, 辻一郎, 呉繁夫, 寳澤篤, 福土審

日本公衆衛生学会総会抄録集　76回　395-395　2017年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災による家屋の被災状況と骨密度の関連東北メディカル・メガバンク事業

成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 坂田清美, 菊谷昌浩, 高井貴子, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　76回　409-409　2017年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東北メディカル・メガバンク計画地域住民コホート調査における参加者の筋力について

永井雅人, 土屋菜歩, 菊谷昌浩, 中谷直樹, 成田暁, 中村智洋, 小暮真奈, 丹野高三, 坂田清美, 菅原準一, 辻一郎, 呉繁夫, 栗山進一, 寳澤篤

日本公衆衛生学会総会抄録集　76回　652-652　2017年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
母体出生体重と妊娠高血圧症候群の関連三世代コホート調査での検討

和形麻衣子, 土屋菜歩, 中谷直樹, 目時弘仁, 寳澤篤, 栗山進一, 八重樫伸生, 菅原準一

日本妊娠高血圧学会雑誌　24　58-58　2017年9月
出版者・発行元：日本妊娠高血圧学会
ISSN： 1880-3172
飲酒量と推定食塩摂取量との関連:東北メディカル・メガバンク計画地域住民コホート調査

小暮真奈, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 坪田(宇津木, 恵, 丹野高三, 寳澤篤

日本アルコール・薬物医学会雑誌　52　(4)　204　2017年8月

ISSN： 1341-8963
東日本大震災被災コミュニティの就労状況と精神的健康に関する縦断的研究

片柳光昭, 瀬戸萌, 根本晴美, 菅原由美, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小高晃, 辻一郎, 寳澤篤, 富田博秋

日本社会精神医学会雑誌　26　(3)　240-241　2017年8月
出版者・発行元： (一社)日本社会精神医学会
ISSN： 0919-1372
尿ナトカリ計を特定健康診査・特定保健指導に活用した自治体の新たな試み

小暮真奈, 宮川健, 土屋菜歩, 中村智洋, 中谷直樹, 安田純, 寳澤篤

東北公衆衛生学会誌　(66)　21-21　2017年7月
出版者・発行元：東北公衆衛生学会
ISSN： 0915-549X
性・年齢階級別にみた東日本大震災後の平均歩数地域住民コホート調査

中谷直樹, 成田暁, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 坂田清美, 菊谷昌浩, 高井貴子, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

東北公衆衛生学会誌　(66)　29-29　2017年7月
出版者・発行元：東北公衆衛生学会
ISSN： 0915-549X
性・年齢別に見た東日本大震災後の地域住民における腎機能と頸動脈内膜中膜複合体厚の関連

土屋菜歩, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 菊谷昌浩, 丹野高三, 菅原準一, 清元秀泰, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

東北公衆衛生学会誌　(66)　30-30　2017年7月
出版者・発行元：東北公衆衛生学会
ISSN： 0915-549X
精神科病院に通院中の統合失調症患者におけるがん検診受診率アンケートによる単施設横断研究

藤原雅樹, 稲垣正俊, 中谷直樹, 樋口裕二, 藤森麻衣子, 林原千夏, 宋龍平, 掛田恭子, 児玉匡史, 内富庸介, 山田了士

精神神経学雑誌　(2017特別号)　S291-S291　2017年6月
出版者・発行元： (公社)日本精神神経学会
ISSN： 0033-2658
Is Ecura System Useful for Deciding Treatment Strategy After Endoscopic Submucosal Dissection that Does Not Meet the Current Curative Criteria for Early Gastric Cancer? a Comparative Study

Waku Hatta, Takuji Gotoda, Tsuneo Oyama, Noboru Kawata, Akiko Takahashi, Yoshikazu Yoshifuku, Shu Hoteya, Masahiro Nakagawa, Masaaki Hirano, Mitsuru Esaki, Mitsuru Matsuda, Ken Ohnita, Kohei Yamanouchi, Motoyuki Yoshida, Osamu Dohi, Jun Takada, Keiko Tanaka, Shinya Yamada, Tsuyotoshi Tsuji, Hirotaka Ito, Yoshiaki Hayashi, Naoki Nakaya, Tomohiro Nakamura, Tooru Shimosegawa

GASTROINTESTINAL ENDOSCOPY　85　(5)　AB75-AB76　2017年5月

ISSN： 0016-5107

eISSN： 1097-6779
Does Submucosal Operation During Endoscopic Submucosal Dissection in Submucosal Invasive Gastric Cancer Enhance Lymph Node Metastasis and Prognosis?: A Multicenter Retrospective Study in Japan

Hirotaka Ito, Takuji Gotoda, Tsuneo Oyama, Noboru Kawata, Akiko Takahashi, Yoshikazu Yoshifuku, Shu Hoteya, Masahiro Nakagawa, Waku Hatta, Masaaki Hirano, Mitsuru Esaki, Mitsuru Matsuda, Ken Ohnita, Ryo Shimoda, Motoyuki Yoshida, Osamu Dohi, Jun Takada, Keiko Tanaka, Shinya Yamada, Tsuyotoshi Tsuji, Yoshiaki Hayashi, Naoki Nakaya, Tomohiro Nakamura, Tooru Shimosegawa

GASTROINTESTINAL ENDOSCOPY　85　(5)　AB445-AB445　2017年5月

DOI： 10.1016/j.gie.2017.03.1036 　

ISSN： 0016-5107

eISSN： 1097-6779
東日本大震災後の宮城県における小中学生の気管支喘息と湿疹の有症率について東北大学東北メディカル・メガバンク機構地域子ども長期健康調査より

宮下真子, 菊谷昌浩, 田中彰二, 山中千鶴, 佐藤ゆき, 水野聖士, 石黒真美, 小原拓, 目時弘仁, 成田暁, 土屋菜歩, 中村智洋, 中谷直樹, 寳澤篤, 辻一郎, 栗山進一

宮城県公衆衛生学会会誌　(49)　14-14　2017年3月
出版者・発行元：宮城県公衆衛生学会
ISSN： 0912-747X
東北メディカル・メガバンク事業地域住民コホート(宮城県)の進捗とこれまでの成果で見えてきたこと

寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 菊谷昌浩, 小原拓, 石黒真美, 佐藤ゆき, 山中千鶴, 宮下真子, 目時弘仁, 栗山進一, 辻一郎

宮城県公衆衛生学会会誌　(49)　17-17　2017年3月
出版者・発行元：宮城県公衆衛生学会
ISSN： 0912-747X
自宅から最寄駅までの距離とBody Mass Indexの関連震災後の住居による層別化解析

土屋菜歩, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 栗山進一, 菅原準一, 呉繁夫, 辻一郎, 寳澤篤

宮城県公衆衛生学会会誌　(49)　18-18　2017年3月
出版者・発行元：宮城県公衆衛生学会
ISSN： 0912-747X
東日本大震災後の沿岸部と内陸部の慢性疾患の治療中断割合の比較

中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 富田博秋, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　27th　100 (WEB ONLY)　2017年1月25日
東日本大震災後の宮城県におけるメタボリック症候群の規定要因:地域住民コホート

中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　27th　103 (WEB ONLY)　2017年1月25日
東日本大震災後における自宅から最寄駅までの距離とBMIの関連は食事パターンで説明できるか

小暮真奈, 成田暁, 土屋菜歩, 中村智洋, 中谷直樹, 丹野高三, 坂田清美, 島津太一, 菊谷昌浩, 菅原準一, 栗山進一, 呉繁夫, 辻一郎, 寳澤篤

日本疫学会学術総会講演集(Web)　27th　88 (WEB ONLY)　2017年1月25日
東日本大震災後の内陸部と沿岸部の胃がんリスク比較

土屋菜歩, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 菊谷昌浩, 菅原準一, 栗山進一, 呉繁夫

日本疫学会学術総会講演集(Web)　27th　130 (WEB ONLY)　2017年1月25日
東日本大震災後のメンタルヘルスの内陸‐沿岸較差:東北メディカル・メガバンク事業

成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 冨田博秋, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　27th　126 (WEB ONLY)　2017年1月25日
重症精神障害相当の心理的苦痛とがん検診受診行動との関連の検討―国民生活基礎調査匿名データの解析

藤原雅樹, 稲垣正俊, 中谷直樹, 樋口裕二, 藤森麻衣子, 掛田恭子, 内富庸介, 山田了士

日本疫学会学術総会講演集(Web)　27th　129 (WEB ONLY)　2017年1月25日
社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 飲酒と高血圧との関連はフラッシング反応により修飾されるか:NIPPON DATA2010

小暮真奈, 土屋菜歩, 寳澤篤, 中谷直樹, 中村智洋, 宮松直美, 田中英夫, 若林一郎, 東山綾, 奥田奈賀子, 高嶋直敬, 藤吉朗, 門田文, 大久保孝義, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成28年度総括・分担研究報告書(Web)　49‐50 (WEB ONLY)　2017年
OMEGA-3 FATTY ACIDS FOR PREGNANT WOMEN WITH DEPRESSIVE SYMPTOMS IN JAPAN AND TAIWAN: AN OPEN-LABEL TRIAL

D. Nishi, K. P. Su, K. Usuda, Y. J. Chiang, T. W. Guu, K. Hamazaki, N. Nakaya, T. Sone, Y. Sano, H. Ito, K. Isaka, K. Hashimoto, T. Hamazaki, Y. J. Matsuoka

INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE　23　S20-S20　2016年11月

ISSN： 1070-5503

eISSN： 1532-7558
東日本大震災における外傷と心理的苦痛の関連七ヶ浜健康増進プロジェクト

成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 辻一郎, 寳澤篤, 富田博秋

日本公衆衛生学会総会抄録集　75回　208-208　2016年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災被災状況とうつ病及びPTSD罹患リスクとの関連

高梨信之, 丹野高三, 佐々木亮平, 大塚耕太郎, 坂田清美, 中谷直樹, 寳澤篤, 栗山進一, 辻一郎, 中村元行, 人見次郎

日本公衆衛生学会総会抄録集　75回　579-579　2016年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災被災地住民の健康知識に関連する要因の検討

佐々木亮平, 丹野高三, 中谷直樹, 寳澤篤, 高梨信之, 坂田清美, 清水厚志

日本公衆衛生学会総会抄録集　75回　581-581　2016年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災後の自宅から最寄駅までの距離と高血圧治療中断に関する地理疫学的検討

土屋菜歩, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 坂田清美, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　75回　253-253　2016年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災後の身体活動量とこころの健康の関連地域住民コホート調査

中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 坂田清美, 富田博秋, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　75回　288-288　2016年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
沿岸部居住者における東日本大震災後の新規うつ病・PTSD罹患リスク

中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 坂田清美, 富田博秋, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　75回　303-303　2016年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災後の現在の居住地と食事パターンの関連地域住民コホート調査

小暮真奈, 成田暁, 土屋菜歩, 中村智洋, 中谷直樹, 丹野高三, 坂田清美, 島津太一, 菊谷昌浩, 菅原準一, 栗山進一, 呉繁夫, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　75回　304-304　2016年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東北メディカル・メガバンク事業地域住民コホート調査の進捗について

寳澤篤, 丹野高三, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 佐々木亮平, 高梨信之, 坂田清美, 菅原準一, 栗山進一, 中村元行, 呉繁夫, 辻一郎

日本公衆衛生学会総会抄録集　75回　381-381　2016年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
妊婦におけるうつ症状軽減を目指したオメガ3系脂肪酸によるオープン試験

西大輔, Su Kuan-Pin, 臼田謙太郎, Chiang Yi-Ju Jill, Guu Tai-Wei, 浜崎景, 中谷直樹, 曽根稔雅, 佐野養, 伊東宏絵, 井坂恵一, 橋本謙二, 浜崎智仁, 松岡豊

脂質栄養学　25　(2)　141-141　2016年8月
出版者・発行元：日本脂質栄養学会
ISSN： 1343-4594
Higher levels of gastrointestinal symptom-specific anxiety are associated with increased risk of presence of irritable bowel syndrome

Tatsuo Saigo, Jun Tayama, Sayaka Ogawa, Atsushi Takeoka, Toyohiro Hamaguchi, Naoki Nakaya, Shin Fukudo, Susumu Shirabe

INTERNATIONAL JOURNAL OF PSYCHOLOGY　51　146-146　2016年7月

ISSN： 0020-7594

eISSN： 1464-066X
震災1年後の将来の住宅の見通しと心理的苦痛リスク

中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 辻一郎, 寳澤篤, 富田博秋

東北公衆衛生学会誌　(65)　14-14　2016年7月
出版者・発行元：東北公衆衛生学会
ISSN： 0915-549X
機能性ディスペプシアにおけるクロロゲン酸コーヒー飲料のディスペプシア症状および消化管ホルモンへの影響

矢神里紗, 庄司知隆, 中谷直樹, 中村智洋, 遠藤由香, 佐藤康弘, 町田知美, 町田貴胤, 鹿野理子, 金澤素, 中谷久美, 村椿智彦, 相澤祐一, 小室葉月, 佐々木彩加, 竹下尚男, 水野智仁, 渡辺卓也, 福土審

心身医学　56　(6)　628-628　2016年6月
出版者・発行元： (一社)日本心身医学会
ISSN： 0385-0307
東日本大震災1年後の沿岸部被災地における心理的苦痛と高血圧治療中断の関連七ヶ浜健康増進プロジェクト

中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 辻一郎, 寳澤篤, 富田博秋

日本循環器病予防学会誌　51　(2)　134-134　2016年5月
出版者・発行元： (一社)日本循環器病予防学会
ISSN： 1346-6267
自宅から最寄駅までの距離と歩行習慣及びBody Mass Indexの関連東北メディカル・メガバンク事業地域住民コホート調査

土屋菜歩, 中谷直樹, 中村智洋, 成田暁, 清元秀泰, 栗山進一, 呉繁夫, 辻一郎, 寳澤篤

日本循環器病予防学会誌　51　(2)　124-124　2016年5月
出版者・発行元： (一社)日本循環器病予防学会
ISSN： 1346-6267
東日本大震災後の宮城県沿岸部における治療中断東北メディカル・メガバンク事業地域住民コホート調査

中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 中谷純, 峯岸直子, 布施昇男, 鈴木洋一, 菅原準一, 菊谷昌浩, 富田博秋, 清元秀泰, 栗山進一, 辻一郎, 呉繁夫, 山本雅之, 寳澤篤, 丹野高三, 佐々木亮平, 坂田清美

宮城県公衆衛生学会会誌　(48)　11-11　2016年3月
出版者・発行元：宮城県公衆衛生学会
ISSN： 0912-747X
随時尿Na/K比,随時尿からの推定食塩摂取量と血圧値の相関について―東北メディカル・メガバンク事業―

寳澤篤, 清元秀泰, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 菅原準一, 布施昇男, 菊谷昌浩, 鈴木洋一, 荻島創一, 高井貴子, 峯岸直子, 栗山進一, 辻一郎, 呉繁夫, 丹野高三, 佐々木亮平, 坂田清美

Journal of Epidemiology (Web)　26　(Supplement 1)　123　2016年1月21日

ISSN： 1349-9092
東日本大震災後の宮城県におけるメタボリック症候群の規定要因:地域住民コホート調査

中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 丹野高三, 佐々木亮平, 坂田清美, 高井貴子, 荻島創一, 峯岸直子, 清元秀泰, 鈴木洋一, 菅原準一, 布施昇男, 菊谷昌浩, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

Journal of Epidemiology (Web)　26　(Supplement 1)　124　2016年1月21日

ISSN： 1349-9092
随時尿Na/K比,随時尿からの推定食塩摂取量と血圧値の相関について―東北メディカル・メガバンク事業―

寳澤篤, 清元秀泰, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 菅原準一, 布施昇男, 菊谷昌浩, 鈴木洋一, 荻島創一, 高井貴子, 峯岸直子, 栗山進一, 辻一郎, 呉繁夫, 丹野高三, 佐々木亮平, 坂田清美

Journal of Epidemiology (Web)　26　(Supplement 1)　123　2016年1月21日

ISSN： 0917-5040
東日本大震災後の宮城県におけるメタボリック症候群の規定要因:地域住民コホート調査

中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 丹野高三, 佐々木亮平, 坂田清美, 高井貴子, 荻島創一, 峯岸直子, 清元秀泰, 鈴木洋一, 菅原準一, 布施昇男, 菊谷昌浩, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

Journal of Epidemiology (Web)　26　(Supplement 1)　124　2016年1月21日

ISSN： 0917-5040
Estimation of allele frequency of pathological variants based on whole-genome sequencing of 1070 Japanese individuals

Yumi Yamaguchi-Kabata, Yosuke Kawai, Kaname Kojima, Naoki Nariai, Takahiro Mimori, Yukuto Sato, Fumiki Katsuoka, Jun Yasuda, Masayuki Yamamoto, Masao Nagasaki

GENES & GENETIC SYSTEMS　90　(6)　379-379　2015年12月

ISSN： 1341-7568

eISSN： 1880-5779
Whole-genome Japanese Reference Panel and future directions

Masao Nagasaki, Jun Yasuda, Fumiki Katsuoka, Naoki Nariai, Kaname Kojima, Yosuke Kawai, Yumi Yamaguchi-Kabata, Junji Yokozawa, Inaho Danjoh, Sakae Saito, Yukuto Sato, Takahiro Mimori, Kaoru Tsuda, Rumiko Saito, Pan Xiaoqing, Satoshi Nishikawa, Shin Ito, Yoko Kuroki, Osamu Tanabe, Nobuo Fuse, Shinichi Kuriyama, Hideyasu Kiyomoto, Atsushi Hozawa, Naoko Minegishi, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto

GENES & GENETIC SYSTEMS　90　(6)　377-377　2015年12月

ISSN： 1341-7568

eISSN： 1880-5779
東北メディカル・メガバンク地域住民コホート調査(宮城)における高血圧の規定要因

寳澤篤, 清元秀泰, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小原拓, 目時弘仁, 丹野高三, 中谷純, 菊谷昌浩, 栗山進一, 辻一郎, 呉繁夫, 山本雅之

日本公衆衛生学会総会抄録集　74回　260-260　2015年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東北メディカル・メガバンク地域住民コホート調査(宮城)における高血圧の規定要因

寳澤篤, 清元秀泰, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小原拓, 目時弘仁, 丹野高三, 中谷純, 菊谷昌浩, 栗山進一, 辻一郎, 呉繁夫, 山本雅之

日本公衆衛生学会総会抄録集　74回　260-260　2015年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災後の高血圧の治療中断と関連する要因地域住民コホート調査

中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 丹野高三, 佐々木亮平, 坂田清美, 中谷純, 菊谷昌浩, 清元秀泰, 栗山進一, 辻一郎, 呉繁夫, 山本雅之, 寳澤篤

日本公衆衛生学会総会抄録集　74回　261-261　2015年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災後の宮城県における歯科受診状況と関連因子についての検討

土屋菜歩, 坪井明人, 白石成, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 鈴木洋一, 菊谷昌浩, 富田博秋, 栗山進一, 辻一郎, 呉繁夫, 山本雅之, 寳澤篤

日本公衆衛生学会総会抄録集　74回　261-261　2015年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
宮城県地域住民における心理的苦痛と喫煙行動の関連についての検討

成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 佐々木亮平, 坂田清美, 富田博秋, 栗山進一, 辻一郎, 呉繁夫, 山本雅之, 寳澤篤

日本公衆衛生学会総会抄録集　74回　296-296　2015年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災後の睡眠薬服用開始に関連する規定要因の検討地域住民コホート調査

中村智洋, 富田博秋, 中谷直樹, 土屋菜歩, 成田暁, 中谷純, 菊谷昌浩, 栗山進一, 辻一郎, 呉繁夫, 山本雅之, 寳澤篤, 丹野高三, 佐々木亮平, 坂田清美

日本公衆衛生学会総会抄録集　74回　296-296　2015年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東北メディカル・メガバンク地域住民コホート宮城エリアにおける随時尿Na/K比の内陸部・沿岸部比較

寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 佐々木亮平, 坂田清美, 中谷純, 峯岸直子, 清元秀泰, 菅原準一, 布施昇男, 菊谷昌浩, 鈴木洋一, 富田博秋, 栗山進一, 辻一郎, 呉繁夫, 八重樫伸生, 山本雅之

日本循環器病予防学会誌　50　(2)　126-126　2015年6月
出版者・発行元： (一社)日本循環器病予防学会
ISSN： 1346-6267
東日本大震災後の小中学生の保護者が抱く子どもの不安と悩みの特徴宮城県南部の実態調査から

佐藤ゆき, 菊谷昌浩, 宮下真子, 山中千鶴, 石黒真美, 小原拓, 目時弘仁, 土屋菜歩, 中村智洋, 中谷直樹, 寳澤篤, 辻一郎, 呉繁夫, 八重樫伸生, 栗山進一

小児保健研究　74　(講演集)　139-139　2015年5月
出版者・発行元： (公社)日本小児保健協会
ISSN： 0037-4113
Irritable Bowel Syndrome in university students is associated with higher experiencing maladjustment and employment anxiety

J. Tayama, N. Nakaya, T. Hamaguchi, T. Saigo, S. Ogawa, T. Sone, S. Fukudo, S. Susumu

PSYCHOTHERAPY AND PSYCHOSOMATICS　84　71-71　2015年

ISSN： 0033-3190

eISSN： 1423-0348
東日本大震災被災者の喪失と悲嘆のプロファイル

小林奈津子, 新宮古都美, 庄子朋香, 北田友子, 中谷直樹, 中村智洋, 土屋菜歩, 吉田弘和, 菊地紗耶, 本多奈美, 松岡洋夫, 中島聡美, 寳澤篤, 辻一郎, 富田博秋

日本精神神経学会総会プログラム・抄録集　111th　(2015特別)　S.364-S364　2015年
出版者・発行元： (公社)日本精神神経学会
ISSN： 0033-2658
Psychosocial Longitudinal Study Profile and Distress of Couples in Relation to the Conduct of Prostate Biopsy

Akira Oba, Naoki Nakaya, Masaru Hasumi, Kumiko Yanaba-Ono, Kumi Saito-Nakaya, Hiroyuki Takechi, Seiji Arai, Nobuaki Shimizu

PSYCHO-ONCOLOGY　23　406-406　2014年10月

ISSN： 1057-9249

eISSN： 1099-1611
東日本大震災での笑いの規定要因と精神的健康度の推測七ヶ浜健康増進プロジェクト

中村智洋, 中谷直樹, 土屋菜歩, 辻一郎, 寳澤篤, 富田博秋

日本公衆衛生学会総会抄録集　73回　239-239　2014年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災の被災地における慢性疾患治療と就労の関連七ヶ浜健康増進プロジェクト

中谷直樹, 中村智洋, 土屋菜歩, 辻一郎, 寳澤篤, 富田博秋

日本公衆衛生学会総会抄録集　73回　270-270　2014年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
ソーシャルキャピタルと健康状態との関連家屋の被災程度との交互作用の検討

土屋菜歩, 中谷直樹, 中村智洋, 辻一郎, 寳澤篤, 富田博秋

日本公衆衛生学会総会抄録集　73回　480-480　2014年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
NEUROTICISM AND IRRITABLE BOWEL SYNDROME

J. Tayama, S. Fukudo, N. Nakaya, T. Hamaguchi, T. Tomiie, M. Shinozaki, T. Saigo, S. Shirabe

INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE　21　S128-S129　2014年8月

ISSN： 1070-5503

eISSN： 1532-7558
過敏性腸症候群の大学生における修業状況心身症のモデル病態における修業上の問題

田山淳, 西郷達雄, 小川さやか, 中谷直樹, 濱口豊太, 福士審, 林田雅希, 調漸

全国大学保健管理研究集会プログラム・抄録集　52回　44-44　2014年8月
出版者・発行元： (公社)全国大学保健管理協会
各種災害関連ストレスが東日本大震災沿岸部被災者の精神的健康に及ぼす影響の検討

鈴木大輔, 中谷直樹, 中村智洋, 中島聡美, 金吉晴, 辻一郎, 寳澤篤, 富田博秋

日本社会精神医学会雑誌　23　(3)　259-259　2014年8月
出版者・発行元： (一社)日本社会精神医学会
ISSN： 0919-1372
うつ予防を目的とした集団認知行動療法の効果ハイリスクな大学新入生への介入査読有り

田山淳, 西郷達雄, 小川さやか, Bernick Peter, 福原視美, 濱口豊太, 富家直明, 中谷直樹, 林田雅希, 調漸

CAMPUS HEALTH　51　(1)　455-457　2014年3月
出版者・発行元： (公社)全国大学保健管理協会
ISSN： 1341-4313

eISSN： 2432-9460
東北メディカル・メガバンク事業―地域住民コホート調査に関する経過報告

寶澤篤, 寶澤篤, 寶澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 菊谷昌浩, 目時弘仁, 小原拓, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 中谷直樹, 中村智洋, 土屋菜歩, 菊谷昌浩, 目時弘仁, 小原拓, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 富田博秋, 富田博秋, 富田博秋, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生, 山本雅之, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生, 山本雅之

J Epidemiol　24　(Supplement 1)　67　2014年1月23日

ISSN： 0917-5040
東北メディカル・メガバンク事業―三世代コホート調査に関する経過報告

目時弘仁, 小原拓, 石黒真美, 成川洋子, 菊谷昌浩, 目時弘仁, 小原拓, 石黒真美, 成川洋子, 菊谷昌浩, 栗山進一, 栗山進一, 栗山進一, 中谷直樹, 寶澤篤, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 中谷直樹, 寶澤篤, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 富田博秋, 富田博秋, 富田博秋, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生

J Epidemiol　24　(Supplement 1)　67　2014年1月23日

ISSN： 0917-5040
慢性疾患治療者における心理的苦痛に関する研究七ヶ浜健康増進プロジェクト

中谷直樹, 中村智洋, 辻一郎, 寳澤篤, 富田博秋

日本公衆衛生学会総会抄録集　72回　198-198　2013年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
東日本大震災における喫煙・飲酒の行動変化と規定要因七ヶ浜健康増進プロジェクト

中村智洋, 中谷直樹, 辻一郎, 寳澤篤, 富田博秋

日本公衆衛生学会総会抄録集　72回　198-198　2013年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
過敏性腸症候群に対する自律訓練法のエビデンス

篠崎雅江, 金澤素, 鹿野理子, 遠藤由香, 中谷直樹, 本郷道夫, 福土審

日本自律訓練学会大会プログラム・発表抄録集　36th　23-23　2013年9月6日
出版者・発行元：日本自律訓練学会
震災救援者におけるPTSD症状の予測因子に関する検討

西大輔, 中谷直樹, 曽根稔雅, 野口普子, 浜崎景, 浜崎智仁, 小井土雄一, 松岡豊

国立精神・神経医療研究センター精神保健研究所年報　(26)　247-247　2013年9月
出版者・発行元： (国研)国立精神・神経医療研究センター精神保健研究所
東日本大震災沿岸部被災者の精神的健康の変遷と現況

鈴木大輔, 築田美抄, 上田穫, 中谷直樹, 金吉晴, 辻一郎, 寶澤篤, 富田博秋

精神神経学雑誌　(2013特別)　S-568　2013年5月
出版者・発行元： (公社)日本精神神経学会
ISSN： 0033-2658
FISH OIL FOR ATTENUATING POSTTRAUMATIC STRESS SYMPTOMS AMONG RESCUE WORKERS AFTER THE GREAT EAST JAPAN EARTHQUAKE: A RANDOMIZED CONTROLLED TRIAL

Yutaka Matsuoka, Daisuke Nishi, Yu-ichi Koido, Naoki Nakaya, Toshimasa Sone, Hiroko Noguchi, Kei Hamazaki, Tomohito Hamazaki

PSYCHOSOMATIC MEDICINE　75　(3)　A131-A131　2013年4月

ISSN： 0033-3174

eISSN： 1534-7796
PERITRAUMATIC DISTRESS, WATCHING TELEVISION AND POSTTRAUMATIC STRESS SYMPTOMS AMONG RESCUE WORKERS AFTER THE GREAT EAST JAPAN EARTHQUAKE

Daisuke Nishi, Yu-ichi Koido, Naoki Nakaya, Toshimasa Sone, Hiroko Noguchi, Kei Hamazaki, Tomohito Hamazaki, Yutaka Matsuoka

PSYCHOSOMATIC MEDICINE　75　(3)　A103-A103　2013年4月

ISSN： 0033-3174

eISSN： 1534-7796
大学生のメンタルヘルスとIBS

田山淳, 中谷直樹, 濱口豊太, 富家直明, 篠崎雅江, 西郷達雄, 調漸, 福土審

行動医学研究　19　(Supplement)　55　2013年3月

ISSN： 1341-6790
睡眠時間と総死亡・死因別死亡リスク大崎国保コホート研究

柿崎真沙子, 栗山進一, 中谷直樹, 曽根稔雅, 永井雅人, 菅原由美, 寳澤篤, 辻一郎

宮城県公衆衛生学会会誌　(45)　4-4　2013年3月
出版者・発行元：宮城県公衆衛生学会
ISSN： 0912-747X
心理社会的要因とがん発症・生存に関する最新データ

中谷直樹

緩和ケア　23　217　2013年
FISH OIL FOR ATTENUATING POSTTRAUMATIC STRESS SYMPTOMS AMONG RESCUE WORKERS AFTER THE GREAT EAST JAPAN EARTHQUAKE: A RANDOMIZED CONTROLLED TRIAL

D. Nishi, Y. Koido, N. Nakaya, T. Sone, H. Noguchi, K. Hamazaki, T. Hamazaki, Y. Matsuoka

INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE　19　S21-S22　2012年9月

ISSN： 1070-5503

eISSN： 1532-7558
THE EFFECTS OF PERSONALITY ON IRRITABLE BOWEL SYNDROME

J. Tayama, N. Nakaya, T. Hamaguchi, T. Tomiie, M. Shinozaki, T. Saigo, M. Hayashida, S. Fukudo

INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE　19　S55-S55　2012年9月

ISSN： 1070-5503

eISSN： 1532-7558
高齢者における心理的苦痛と要介護認定・死亡リスクの関連:大崎コホート2006研究

渡邉崇, 柿崎真沙子, 中谷直樹, 中谷直樹, 永井雅人, 遠又靖丈, 坪谷透, 栗山進一, 栗山進一, 辻一郎

日本公衆衛生学会総会抄録集　70th　276　2011年10月15日

ISSN： 1347-8060
飲酒と自殺リスクに関する前向きコホート研究 : 大崎コホート研究—分科会アルコール・薬物関連問題と自殺

中谷直樹

日本アルコール関連問題学会雑誌 = The journal of the Japanese Society of Alcohol-related Problems　13　32-34　2011年6月
出版者・発行元：横須賀 : 日本アルコール関連問題学会
ソーシャルキャピタルの地域差に関する研究

坪谷透, 栗山進一, 遠又靖丈, 中谷直樹, 大森(松田)芳, 高橋英子, 寳澤篤, 福地成, 曽根稔雅, 永井雅人, 菅原由美, 星玲奈, 柿崎真沙子, 辻一郎

宮城県公衆衛生学会会誌　(43)　11-11　2011年6月
出版者・発行元：宮城県公衆衛生学会
ISSN： 0912-747X
Relationship between Peripheral Arterial Disease and Incident Disability among Japanese Elderly: the Tsurugaya Project.

A. Nitta, A. Hozawa, S. Kuriyama, N. Nakaya, K. Ohmori-Matsuda, T. Sone, M. Kakizaki, N. Tomita, S. Ebihara, K. Furukawa, M. Ichiki, H. Arai, I. Tsuji

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY　59　S37-S37　2011年4月

ISSN： 0002-8614
大学生版食行動質問票の開発項目反応理論を用いた尺度の精査及び信頼性・妥当性の検証査読有り

田山淳, 山崎浩則, 林田雅希, 玉井慎美, 木村拓也, 中垣内真樹, 富家直明, 濱口豊太, 中谷直樹, 山本玲子, 福士審, 調漸

CAMPUS HEALTH　48　(1)　186-188　2011年2月
出版者・発行元： (公社)全国大学保健管理協会
ISSN： 1341-4313

eISSN： 2432-9460
睡眠時間と要介護認定・死亡リスクに関する前向きコホート研究:鶴ケ谷プロジェクト

柿崎真沙子, 上川康貴, 上川康貴, 中谷直樹, 曽根稔雅, 遠又靖丈, 坪谷透, 渡邊生恵, 寳澤篤, 栗山進一, 辻一郎

J Epidemiol　21　(1 Supplement)　106　2011年1月21日

ISSN： 0917-5040
パーソナリティーと全死因死亡リスクに関する前向きコホート研究:宮城県コホート研究

丹治史也, 柿崎真沙子, 菅原由美, 渡邊生恵, 中谷直樹, 西野善一, 南優子, 深尾彰, 辻一郎

J Epidemiol　21　(1 Supplement)　88　2011年1月21日

ISSN： 0917-5040
介護予防サービスの効果評価に関する研究 1日の総睡眠時間,夜間睡眠時間,要介護認定の関連についての前向きコホート研究—鶴ケ谷プロジェクト—

辻一郎, 柿崎真沙子, 上川康貴, 中谷直樹, 曽根稔雅, 遠又靖丈, 坪谷透, 渡邊生恵, 寳澤篤, 栗山進一

介護予防サービスの効果評価に関する研究平成22年度総括・分担研究報告書　56-60　2011年
高齢者におけるNT‐Pro BNPと要介護認定の関連—鶴ケ谷コホート研究—

寶澤篤, 菅原由美, 遠又靖丈, 柿崎真沙子, 大森芳, 中谷直樹, 栗山進一, 深尾彰, 辻一郎

日本高血圧学会総会プログラム・抄録集　33rd　380　2010年10月15日
大学生版食行動質問票の開発項目反応理論を用いた尺度の精査及び信頼性・妥当性の検証

田山淳, 山崎浩則, 林田雅希, 玉井慎美, 木村拓也, 中垣内真樹, 富家直明, 濱口豊太, 中谷直樹, 山本玲子, 福土審, 調漸

CAMPUS HEALTH　47　(3)　75-75　2010年10月
出版者・発行元： (公社)全国大学保健管理協会
ISSN： 1341-4313

eISSN： 2432-9460
うつ状態と介護保険要支援・要介護認定リスクとの関連鶴ヶ谷プロジェクト

大森芳, 松田, 寳澤篤, 曽根稔雅, 小泉弥生, 宗, 中谷直樹, 栗山進一, 鈴木修治, 粟田主一, 辻一郎

日本公衆衛生雑誌　57　(7)　538-549　2010年7月
出版者・発行元：日本公衆衛生学会
DOI： 10.11236/jph.57.7_538 　

ISSN： 0546-1766
緑茶摂取と肝がん罹患に関する前向きコホート研究

宇井あかね, 栗山進一, 柿崎真沙子, 曽根稔雅, 中谷直樹, 大森(松田)芳, 寳澤篤, 西野善一, 辻一郎

J Epidemiol　20　(Supplement 1)　S112　2010年1月9日

ISSN： 0917-5040
Impact of physical activity and performance on medical care costs among the Japanese elderly

Yang G, Niu K, Fujita K, Hozawa A, Ohmori-Matsuda K, Kuriyama S, Nakaya N, Ebihara S, Okazaki T, Guo H, Miura C, Takahashi H, Arai H, Tsuji I, Nagatomi R

Geriatr Gerontol Int　00　(00)　000-000　2010年

DOI： 10.1111/j.1447-0594.2010.00651.x. 　
介護予防サービスの効果評価に関する研究緑茶摂取と肺炎死亡リスクに関する研究

辻一郎, 渡邊生恵, 栗山進一, 柿崎真沙子, 曽根稔雅, 大森芳, 中谷直樹, 寳澤篤

介護予防サービスの効果評価に関する研究平成21年度総括・分担研究報告書　59-64　2010年
高齢者における血圧と要介護認定の関連鶴ヶ谷コホート研究

寳澤篤, 栗山進一, 大森芳, 曽根稔雅, 新田明美, 菅原由美, 中谷直樹, 牛凱軍, 粟田主一, 辻一郎

日本高血圧学会総会プログラム・抄録集　32回　304-304　2009年10月
出版者・発行元： (NPO)日本高血圧学会
緑茶摂取頻度とK6得点との関連—大崎コホート2006研究—

寳澤篤, 栗山進一, 中谷直樹, 大森芳, 柿崎真沙子, 曽根稔雅, 永井雅人, 新田明美, 菅原由美, 牛凱軍, 辻一郎

J Epidemiol　19　(1 Supplement)　210　2009年1月24日

ISSN： 0917-5040
Motor Fitness Scaleと要介護発生・死亡リスクに関する前向きコホート研究—鶴ケ谷プロジェクト—

星真行, 星真行, 寳澤篤, 栗山進一, 中谷直樹, 大森芳, 曽根稔雅, 柿崎真沙子, 牛凱軍, 藤田和樹, 植木章三, 芳賀博, 永富良一, 辻一郎

J Epidemiol　19　(1 Supplement)　198　2009年1月24日

ISSN： 0917-5040
睡眠時間と乳がん罹患リスクに関する前向きコホート研究:大崎国保コホート研究

柿崎真沙子, 柿崎真沙子, 栗山進一, 曽根稔雅, 大森芳, 寳澤篤, 中谷直樹, 福土審, 辻一郎

J Epidemiol　19　(1 Supplement)　67　2009年1月24日

ISSN： 0917-5040
末梢動脈疾患と要介護発生に関する前向きコホート研究〜鶴ケ谷プロジェクト〜

新田明美, 新田明美, 寳澤篤, 栗山進一, 中谷直樹, 大森芳, 曽根稔雅, 柿崎真沙子, 海老原覚, 市来正隆, 荒井啓行, 辻一郎

J Epidemiol　19　(1 Supplement)　199　2009年1月24日

ISSN： 0917-5040
要介護認定者における要介護状態区分の推移に関する研究

曽根稔雅, 中谷直樹, 大森芳, 寳澤篤, 栗山進一, 辻一郎

日本公衆衛生学会総会抄録集　67回　519-519　2008年10月
出版者・発行元：日本公衆衛生学会
ISSN： 1347-8060
Sense of life worth living (ikigai) and mortality in Japan: Ohsaki Study

Toshimasa Sone, Naoki Nakaya, Kaori Ohmori, Taichi Shimazu, Mizuka Higashiguchi, Masako Kakizaki, Nobutaka Kikuchi, Shinichi Kuriyama, Ichiro Tsuji

PSYCHOSOMATIC MEDICINE　70　(6)　709-715　2008年7月

DOI： 10.1097/PSY.0b013e31817e7e64 　

ISSN： 0033-3174
自殺問題と予防対策:厚生労働省戦略研究都市における自殺予防対策

粟田主一, 今城周造, 滑川明夫, 中谷直樹, 小泉弥生, 井藤佳恵, 本多奈美, 新解敏恭, 岡崎伸郎, 並河紋子, 菅原広子

精神神経学雑誌　110　(3)　222-229　2008年3月
出版者・発行元： (公社)日本精神神経学会
ISSN： 0033-2658
【ストレスと疾患の関係】ストレスとがん罹患リスクに関する疫学研究

中谷直樹, 内富庸介

ストレス科学研究　23　1-7　2008年3月
出版者・発行元： (公財)パブリックヘルスリサーチセンター
ISSN： 1341-9986
高感度C反応性蛋白レベルと介護保険認定・死亡リスクに関する前向きコホート研究:鶴ケ谷プロジェクト

曽根稔雅, 牛凱軍, 中谷直樹, 大森芳, 東口みづか, 柿崎真沙子, 寳澤篤, 栗山進一, 辻一郎

J Epidemiol　18　(1 Supplement)　122　2008年1月25日

ISSN： 0917-5040
睡眠時間と前立腺がん罹患リスクに関する前向きコホート研究:大崎国保コホート研究

柿崎真沙子, 柿崎真沙子, 井上圭祐, 栗山進一, 中谷直樹, 曽根稔雅, 大森芳, 福土審, 辻一郎

J Epidemiol　18　(1 Supplement)　54　2008年1月25日

ISSN： 0917-5040
緑茶摂取と肺炎死亡リスクに関する前向きコホート研究:大崎国保コホート研究

渡邊生恵, 栗山進一, 柿崎真沙子, 曽根稔雅, 大森芳, 中谷直樹, 辻一郎

J Epidemiol　18　(1 Supplement)　210　2008年1月25日

ISSN： 0917-5040
初産年齢と長期的死亡リスクに関する前向きコホート研究:大崎国保コホート研究

酒井太一, 中谷直樹, 角田雪香, 柿崎真沙子, 曽根稔雅, 大森芳, 栗山進一, 辻一郎

J Epidemiol　18　(1 Supplement)　108　2008年1月25日

ISSN： 0917-5040
Does nocturia increase fall-related fractures and mortality in a community-dwelling elderly population aged 70 years and over? Results of a 3-year prospective cohort study in Japan

H. Nakagawa, Y. Ikeda, K. Niu, Y. Kaiho, K. Ohmori-Matsuda, N. Nakaya, R. Imanishi, R. Nagatomi, Tsuji, I, Y. Arai

NEUROUROLOGY AND URODYNAMICS　27　(7)　674-675　2008年

ISSN： 0733-2467
生活習慣・健診結果が生涯医療費に及ぼす影響に関する研究生活習慣,既往歴,日常生活の状況,人生観,健診・検診受診歴が医療費に及ぼす影響に関する研究—大崎国保コホート研究—

辻一郎, 栗山進一, 渡邊生恵, 柿崎真沙子, 中谷直樹, 大森芳

生活習慣・健診結果が生涯医療費に及ぼす影響に関する研究平成19年度研究報告書　11-20　2008年
生活習慣・健診結果が生涯医療費に及ぼす影響に関する研究生活習慣,既往歴,日常生活の状況,人生観,健診・検診受診歴が死亡リスクに及ぼす影響に関する研究—大崎国保コホート研究—

辻一郎, 渡邊生恵, 柿崎真沙子, 栗山進一, 中谷直樹, 大森芳

生活習慣・健診結果が生涯医療費に及ぼす影響に関する研究平成19年度研究報告書　21-29　2008年
高齢者での低レベルの血清CRP濃度と体力低下との関連

牛凱軍, 寳澤篤, 郭輝, 栗山進一, 楊光, 大森芳, 中谷直樹, 高橋英子, 藤田和樹, 辻一郎, 永富良一

体力科学　56　(6)　806-806　2007年12月
出版者・発行元： (一社)日本体力医学会
ISSN： 0039-906X

eISSN： 1881-4751
睡眠時間と死亡リスクに関する前向きコホート研究：大崎コホート研究 (Supplement to Journal of Epidemiology)

柿崎真沙子, 中谷直樹, 大森芳, 島津太一, 栗山進一, 福土審, 辻一郎

Supplement to Journal of Epidemiology　96　2007年10月
心理社会的要因とがん罹患/生存--パーソナリティを中心として—Psychosocial factors and cancer risk and/or cancer survival

中谷直樹

腫瘍内科 = Clinical oncology / 腫瘍内科編集委員会編　1　(4)　383-388　2007年8月
出版者・発行元：東京 : 科学評論社
ISSN： 1881-6568
効果的な介護予防ケアマネジメント技法の開発に関する研究生きがいと死亡リスクに関する前向きコホート研究

辻一郎, 曽根稔雅, 栗山進一, 中谷直樹, 大森芳, 島津太一, 菊地信孝, 柿崎真沙子

効果的な介護予防ケアマネジメント技法の開発に関する研究平成18年度研究報告書　34-43　2007年
Personality traits and cancer survival: a Danish cohort study (vol 95, pg 146, 2006)

N. Nakaya, P. E. Hansen, I. R. Schapiro, L. F. Eplov, K. Saito-Nakaya, Y. Uchitomi, C. Johansen

BRITISH JOURNAL OF CANCER　95　(11)　1610-1610　2006年12月

DOI： 10.1038/sj.bjc.6603489 　

ISSN： 0007-0920
パーソナリティと胃がん検診受診行動に関する横断研究

荒井志津葉, 柿崎真沙子, 中谷直樹, 大森芳, 島津太一, 栗山進一, 辻一郎

日本公衆衛生学会総会抄録集　65th　275　2006年10月15日

ISSN： 1347-8060
コーヒー摂取と大腸がん罹患リスクに関する前向きコホート研究

長沼透, 栗山進一, ムニラアクタル, 柿崎真沙子, 中谷直樹, 大森芳, 島津太一, 辻一郎

日本公衆衛生学会総会抄録集　65th　274　2006年10月15日

ISSN： 1347-8060
パーソナリティとがん患者の生命予後:宮城県コホート研究

中谷直樹, 坪野吉孝, 西野善一, 細川徹, 福土審, 渋谷大助, 中谷久美, 内富庸介, 辻一郎

東北公衆衛生学会誌　(55)　37-37　2006年7月
出版者・発行元：東北公衆衛生学会
ISSN： 0915-549X
アルコール摂取の発がん影響に関する疫学研究 : 人口寄与危険割合の推定

辻一郎, 中谷直樹, 栗山進一

日本アルコール・薬物医学会雑誌 = Japanese journal of alcohol studies & drug dependence　41　(3)　196-197　2006年6月28日

ISSN： 1341-8963
【わが国におけるがん検診の現状と問題点】がん検診の意義地域格差 (クリニカルプラクティス)

中谷直樹, 辻一郎

クリニカルプラクティス　25　(4)　245-249　2006年4月
Personality and cancer survival: The Miyagi Cohort Study

N Nakaya, Y Tsubono, Y Nishino, T Hosokawa, S Fukudo, D Shibuya, N Aki-zuki, E Yoshikawa, M Kobayakawa, M Fujimori, K Saito-Nakaya, Y Uchitomi, Tsuji, I

JOURNAL OF PSYCHOSOMATIC RESEARCH　58　(6)　S42-S42　2005年6月

ISSN： 0022-3999
Efficacy of autogenic training for patients with irritable bowel syndrome

M Shinozaki, M Kano, M Kanazawa, N Nakaya, Y Endo, M Hongo, S Fukudo

JOURNAL OF PSYCHOSOMATIC RESEARCH　58　(6)　S54-S54　2005年6月

ISSN： 0022-3999
【サイコオンコロジーと心身医療】がんと疫学

中谷直樹, 清水研, 大庭章, 内富庸介, 坪野吉孝

心療内科　9　(2)　95-100　2005年3月
出版者・発行元： (有)科学評論社
ISSN： 1342-9892
受賞のことば(第3回池見賞受賞 : Personality and the risk of cancer)

中谷直樹

心身医学　45　(7)　483　2005年
出版者・発行元：一般社団法人日本心身医学会
DOI： 10.15064/jjpm.45.7_483_2 　

ISSN： 0385-0307

eISSN： 2189-5996
心身症の診断・治療ガイドラインを用いた評価法の開発に関する研究過敏性腸症候群の症状評価法の開発と診断・治療ガイドラインの検証に関する研究

福土審, 篠崎雅江, 鹿野理子, 金沢素, 中谷直樹, 吉沢正彦, 遠藤由香, 本郷道夫

心身症の診断・治療ガイドラインを用いた評価法の開発に関する研究平成14-16年度総括研究報告書　73-109　2005年
Personality and the risk of cancer

N Nakaya, Y Tsubono, T Hosokawa, S Fukudo, Tsuji, I

PSYCHO-ONCOLOGY　13　(8)　S4-S5　2004年8月

ISSN： 1057-9249
肉類摂取と大腸がん罹患に関する前向きコホート研究

佐藤ゆき, 中谷直樹, 栗山進一, 西野善一, 坪野吉孝, 辻一郎

東北公衆衛生学会誌　(53)　25-25　2004年7月
出版者・発行元：東北公衆衛生学会
ISSN： 0915-549X
パーソナリティーとがん罹患に関する前向きコホート研究(シンポジウム/サイコオントロジーの新たな展開)(第44回日本心身医学会総会)

中谷直樹, 坪野吉孝, 細川徹, 西野善一, 大久保孝義, 寶澤篤, 渋谷大助, 福土審, 深尾彰, 辻一郎, 久道茂

心身医学　44　(7)　471-477　2004年7月1日
出版者・発行元：日本心身医学会
DOI： 10.15064/jjpm.44.7_471 　

ISSN： 0385-0307

詳細を見る詳細を閉じる

パーソナリティーとがん罹患リスクとの関連を,7年間の前向きコホート研究にて検討した.40〜64歳の一般地域住民30,277名を解析対象とした.Eysenck Personality Questionnaire-Revised(EPQ-R)の「E尺度(extraversion);外向性傾向」「N尺度(neuroticlsm);神経症傾向」「P尺度(psychoticism);非協調性」「L尺度(lie);虚構性」の4つの下位尺度が,がん罹患リスクに及ぼす影響は認められなかった.しかしながら,神経症傾向が,がん罹患の原因ではなく結果である可能性が示唆された.
飲酒と全死因死亡に関する前向きコホート研究

倉嶋佳誉子, 中谷直樹, 山口純子, 大久保孝義, 西野善一, 坪野吉孝, 辻一郎, 久道茂, 福土審

宮城県公衆衛生学会会誌　(36)　6-6　2004年3月
出版者・発行元：宮城県公衆衛生学会
ISSN： 0912-747X
性格と癌罹患に関する前向きコホート研究(第55回日本心身医学会東北地方会演題抄録)

中谷直樹, 坪野吉孝, 西野善一, 大久保孝義, 寶澤篤, 細川徹, 渋谷大助, 福土審, 辻一郎

心身医学　44　(2)　153-153　2004年2月1日
出版者・発行元：日本心身医学会
DOI： 10.15064/jjpm.44.2_153_1 　

ISSN： 0385-0307
Re: Personality and the risk of cancer (multiple letters) [1]

Christian Murr, Dietmar Fuchs, Yoshitaka Tsubono, Naoki Nakaya, Ichiro Tsuji

Journal of the National Cancer Institute　95　(21)　1638　2003年11月5日

ISSN： 0027-8874
Re: Personality and the risk of cancer - Response

Y Tsubono, N Nakaya, Tsuji, I

JOURNAL OF THE NATIONAL CANCER INSTITUTE　95　(21)　1638-1638　2003年11月

DOI： 10.1093/jnci/djg093 　

ISSN： 0027-8874
高齢者における過敏性腸症候群及び機能性消化管障害の抑うつ症状とQuality of Life

中谷直樹, 藤田和樹, 寳澤篤, 小泉弥生, 大森芳, 倉嶋佳誉子, 辻一郎, 粟田主一, 福土審

老年精神医学雑誌　14　(5)　628-628　2003年5月
出版者・発行元： (株)ワールドプランニング
ISSN： 0915-6305
岩手県大迫町における運動訓練の効果-筋力,バランスなど

藤田和樹, 寳澤篤, 中谷直樹, 大森芳, 鈴木寿則, 山口純子, 辻一郎, 古川順光, 佐藤浩哉, 永富良一

宮城県公衆衛生学会会誌　(35)　7-7　2003年3月
出版者・発行元：宮城県公衆衛生学会
ISSN： 0912-747X
がんの病前性格—サイコオンコロジー--がん患者のこころのケア ; がん患者への告知と情緒状態

中谷直樹, 福土審

現代のエスプリ = L'esprit d'aujourd'hui　(426)　53-62　2003年1月
出版者・発行元：東京 : ぎょうせい
ISSN： 0435-2165
Association between depression and social support in the Japanese elderly population

Y Koizumi, S Awata, T Seki, N Nakaya, S Kuriyama, K Fujita, K Ohmori, A Hozawa, S Ebihara, H Arai, R Nagatomi, H Matsuoka, Tsuji, I

INTERNATIONAL PSYCHOGERIATRICS　15　272-272　2003年

ISSN： 1041-6102
緑茶と胃がん罹患に関する前向きコホート研究

小泉弥生, 坪野吉孝, 中谷直樹, 西野善一, 辻一郎, 渋谷大助, 松岡洋夫, 久道茂

Journal of epidemiology　12　(1)　77-77　2002年1月1日

ISSN： 0917-5040
緑茶と大腸がん罹患に関する前向きコホート研究

鈴木寿則, 坪野吉孝, 中谷直樹, 西野善一, 辻一郎, 渋谷大助, 久道茂

Journal of epidemiology　12　(1)　110-110　2002年1月1日

ISSN： 0917-5040
緑茶と乳がん罹患に関する前向きコホート研究

鈴木洋子, 坪野吉孝, 中谷直樹, 西野善一, 辻一郎, 渋谷大助, 久道茂

Journal of epidemiology　12　(1)　111-111　2002年1月1日

ISSN： 0917-5040
アルコール摂取とがん罹患に関する前向きコホート研究

中谷直樹, 西野善一, 坪野吉孝, 辻一郎, 渋谷大助, 福土審, 久道茂

Journal of epidemiology　12　(1)　98-98　2002年1月1日

ISSN： 0917-5040
IID-12 少年院入院者に対するリラクセーションによる心理的変化(小児科III)

中谷直樹, 熊野宏昭, 美野田啓二, 古口高志, 田之内厚三, 金澤素, 福土審

心身医学　41　123-123　2001年5月1日
出版者・発行元：日本心身医学会
DOI： 10.15064/jjpm.41.supplementII_123_2 　

ISSN： 0385-0307
IIG-22 筋弾性及びその左右のバランスとパーソナリティー及び心理的ストレス反応との関連(性格傾向)

中谷直樹, 熊野宏昭, 美野田啓二, 福土審

心身医学　40　212-212　2000年6月10日
出版者・発行元：日本心身医学会
DOI： 10.15064/jjpm.40.supplement_212_2 　

ISSN： 0385-0307
C-3 水頭症男児の帰属変容と学級適応の向上(ケーススタディ)

富家直明, 中谷直樹, 熊野宏昭, 福土審

日本行動療法学会大会発表論文集　(25)　172-173　1999年11月25日
出版者・発行元：一般社団法人日本認知・行動療法学会
P-42 アローバランスグラフの信頼性及び妥当性の検討(ポスター発表5)

中谷直樹, 熊野宏昭, 福土審, 美野田啓二

日本行動療法学会大会発表論文集　(25)　158-159　1999年11月25日
出版者・発行元：一般社団法人日本認知・行動療法学会
Tsubono Y, Tsuji I, Fujita K, Nakaya N, Hozawa A, Ohkubo T, Kuwahara A, Watanabe Y, Ogawa K, Nishino Y, Hisamichi S. Validation of walking questionnaire for population-based prospective studies in Japan: comparison with pedometer. Journal of Epidemiolo・・・

詳細を見る詳細を閉じる

Tsubono Y, Tsuji I, Fujita K, Nakaya N, Hozawa A, Ohkubo T, Kuwahara A, Watanabe Y, Ogawa K, Nishino Y, Hisamichi S. Validation of walking questionnaire for population-based prospective studies in Japan: comparison with pedometer. Journal of Epidemiology, 12, 305-9, 2002.
Koizumi Y, Tsubono Y, Nakaya N, Nishino Y, Shibuya D, Matsuoka H, Tsuji I. No association between green tea and the risk of gastric cancer: pooled analysis of two prospective studies in Japan. Cancer Epidemiology, Biomarkers & Prevention, 12, 472-47・・・

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Koizumi Y, Tsubono Y, Nakaya N, Nishino Y, Shibuya D, Matsuoka H, Tsuji I. No association between green tea and the risk of gastric cancer: pooled analysis of two prospective studies in Japan. Cancer Epidemiology, Biomarkers & Prevention, 12, 472-473, 2003.
Tsubono Y, Nakaya N, Tsuji I. Personality and the risk of cancer (Response). Journal of the National Cancer Institute, 95, 1638, 2003.
Watanabe T, Nakaya N, Kurashima K, Kuriyama S, Tsubono Y, Tsuji I. Constipation, laxative use and risk of colorectal cancer: The Miyagi Cohort Study. European Journal of Cancer, 40, 2109-2015, 2004.
Suzuki Y, Tsubono Y, Nakaya N, Suzuki Y, Koizumi Y, Tsuji I. Green tea and the risk of breast cancer: pooled analysis of two prospective studies in Japan. British Journal of Cancer, 90, 1361-1363, 2004.
Koizumi Y, Tsubono Y, Nakaya N, Kuriyama S, Shibuya D, Matsuoka H, Tsuji I. Cigarette smoking and the risk of gastric cancer: a pooled analysis of two prospective studies in Japan. International Journal of Cancer, 112, 1049-1055, 2004.
Tsuji I, Nishino Y, Tsubono Y, Suzuki Y, Hozawa A, Nakaya N, Fujita K, Kuriyama S, Shibuya D, Fukao A, Hisamichi S. Follow-up and mortality profiles in the Miyagi Cohort Study. Journal of Epidemiology, 14 (Suppl 1), S2-S6, 2004.
Kuriyama S, Ohmori K, Miura C, Suzuki Y, Nakaya N, Fujita K, Sato Y, Tsubono Y, Tsuji I, Fukao A, Hisamichi S. Body mass index and mortality in Japan: the Miyagi Cohort Study. Journal of Epidemiology, 14 (Suppl 1), S33-S38, 2004.
Tsubono Y, Koizumi Y, Nakaya N, Fujita K, Takahashi H, Hozawa A, Suzuki Y, Kuriyama S, Tsuji I, Fukao A, Hisamichi S. Health practices and mortality in Japan: combined effects of smoking, drinking, walking and body mass index in the Miyagi Cohort Study・・・

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Tsubono Y, Koizumi Y, Nakaya N, Fujita K, Takahashi H, Hozawa A, Suzuki Y, Kuriyama S, Tsuji I, Fukao A, Hisamichi S. Health practices and mortality in Japan: combined effects of smoking, drinking, walking and body mass index in the Miyagi Cohort Study. Journal of Epidemiology, 14 (Suppl 1), S39-S45, 2004.
Sato Y, Tsubono Y, Nakaya N, Ogawa K, Kurashima K, Kuriyama S, Hozawa A, Nishino Y, Shibuya D, Tsuji I. Fruit and vegetable consumption and risk of colorectal cancer in Japan: The Miyagi Cohort Study. Public Health and Nutrition, 8, 309-314, 2005
Suzuki Y, Tsubono Y, Nakaya N, Koizumi Y, Suzuki Y, Shibuya D, Tsuji I. Green tea and the risk of colorectal cancer: pooled analysis of two prospective studies in Japan. Journal of Epidemiology, 15, 118-124, 2005.
Yoshikawa E, Matsuoka Y, Yamasue H, Inagaki M, Nakano T, Akechi T, Kobayakawa M, Fujimori M, Nakaya N, Akizuki N, Imoto S, Murakami K, Kasai K, Uchitomi Y. Prefrontal cortex and amygdala volume in first minor or major depressive episode after cancer di・・・

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Yoshikawa E, Matsuoka Y, Yamasue H, Inagaki M, Nakano T, Akechi T, Kobayakawa M, Fujimori M, Nakaya N, Akizuki N, Imoto S, Murakami K, Kasai K, Uchitomi Y. Prefrontal cortex and amygdala volume in first minor or major depressive episode after cancer diagnosis. Biological Psychiatry, 59, 707-712, 2006.
Kikuchi N, Ohmori K, Shimazu T, Nakaya N, Kuriyama S, Nishino Y, Tsubono Y, Tsuji I. No association between green tea and prostate cancer risk in Japanese men: the Ohsaki Cohort Study. British Journal of Cancer, 95, 371-373, 2006.
Fujimori M, Kobayakawa M, Nakaya N, Nagai K, Nishiwaki Y, Inagaki K, Uchitomi Y. Psychometric properties of the Japanese version of the Quality Of Life-Cancer Survivors Instrument. Quality of Life Research, 15, 1633-1638, 2006.
Niu K, Hozawa A, Kuriyama S, Ohmori-Matsuda K, Shimazu T, Nakaya N, Fujita K, Tsuji I, Nagatomi R. Dietary long-chain n-3 fatty acids of marine origin and serum C-reactive protein concentrations are associated in a population with a diet rich in marine・・・

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Niu K, Hozawa A, Kuriyama S, Ohmori-Matsuda K, Shimazu T, Nakaya N, Fujita K, Tsuji I, Nagatomi R. Dietary long-chain n-3 fatty acids of marine origin and serum C-reactive protein concentrations are associated in a population with a diet rich in marine products. American Journal of Clinical Nutrition, 84, 223-229, 2006.
Kuriyama S, Ebihara S, Hozawa A, Ohmori K, Kurashima K, Nakaya N, Matsui T, Arai H, Tsubono Y, Sasaki H, Tsuji I. Dietary intakes and plasma 8-iso-prostaglandin F2alpha concentrations in community-dwelling elderly Japanese: the Tsurugaya project. In・・・

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Kuriyama S, Ebihara S, Hozawa A, Ohmori K, Kurashima K, Nakaya N, Matsui T, Arai H, Tsubono Y, Sasaki H, Tsuji I. Dietary intakes and plasma 8-iso-prostaglandin F2alpha concentrations in community-dwelling elderly Japanese: the Tsurugaya project. International Journal of Vitamin and Nutrition Research,76, 87-94, 2006.
Sato Y, Nakaya N, Kuriyama S, Nishino Y, Tsubono Y, Tsuji I. Meat consumption and risk of colorectal cancer in Japan: the Miyagi Cohort Study. European Journal of Cancer Prevention, 15, 211-218, 2006.
Ogata M, Kuriyama S, Sato Y, Shimazu T, Nakaya N, Ohmori K, Hozawa A, Tsuji I. Impact of non-dietary nutrients intake on misclassification in the estimation of nutrient intake in epidemiologic study. Journal of Epidemiology, 16, 193-200, 2006.
Kuriyama S, Shimazu T, Ohmori K, Kikuchi N, Nakaya N, Nishino Y, Tsubono Y, Tsuji I. Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study. JAMA, 296, 1255-1265, 2006.
Saito-Nakaya K, Nakaya N, Fujimori M, Akizuki N, Yoshikawa E, Kobayakawa M, Nagai K, Nishiwaki Y, Tsubono Y, Uchitomi Y. Marital status, social support and survival after curative resection in non-small-cell lung cancer. Cancer Science, 97, 206-213,・・・

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Saito-Nakaya K, Nakaya N, Fujimori M, Akizuki N, Yoshikawa E, Kobayakawa M, Nagai K, Nishiwaki Y, Tsubono Y, Uchitomi Y. Marital status, social support and survival after curative resection in non-small-cell lung cancer. Cancer Science, 97, 206-213, 2006.
Miyamoto A, Kuriyama S, Nishino Y, Tsubono Y, Nakaya N, Ohmori K, Kurashima K, Shibuya D, Tsuji I. Lower risk of death from gastric cancer among participants of gastric cancer screening in Japan: a population-based cohort study. Preventive Medicine, 44・・・

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Miyamoto A, Kuriyama S, Nishino Y, Tsubono Y, Nakaya N, Ohmori K, Kurashima K, Shibuya D, Tsuji I. Lower risk of death from gastric cancer among participants of gastric cancer screening in Japan: a population-based cohort study. Preventive Medicine, 44, 12-19, 2007.
Awata S, Bech P, Koizumi Y, Seki T, Kuriyama S, Hozawa A, Ohmori K, Nakaya N, Matsuoka H, Tsuji I. Validity and utility of the Japanese version of the WHO-Five Well-Being Index in the context of detecting suicidal ideation in elderly community resident・・・

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Awata S, Bech P, Koizumi Y, Seki T, Kuriyama S, Hozawa A, Ohmori K, Nakaya N, Matsuoka H, Tsuji I. Validity and utility of the Japanese version of the WHO-Five Well-Being Index in the context of detecting suicidal ideation in elderly community residents. International Journal of Psychogeriatrics, 19, 77-88, 2007.
Akhter M, Kuriyama S, Nakaya N, Shimazu T, Ohmori K, Nishino Y, Tsubono Y, Fukao A, Tsuji I. Alcohol consumption is associated with an increased risk of distal colon and rectal cancer in Japanese men: the Miyagi Cohort Study. European Journal of Can・・・

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Akhter M, Kuriyama S, Nakaya N, Shimazu T, Ohmori K, Nishino Y, Tsubono Y, Fukao A, Tsuji I. Alcohol consumption is associated with an increased risk of distal colon and rectal cancer in Japanese men: the Miyagi Cohort Study. European Journal of Cancer, 43, 383-390, 2007.
Naganuma T, Kuriyama S, Akhter M, Kakizaki M, Nakaya N, Matsuda-Ohmori K, Shimazu T, Fukao A, Tsuji I. Coffee consumption and the risk of colorectal cancer: a prospective cohort study in Japan. International Journal of Cancer, 120, 1542-1547, 2007.
Ohmori-Matsuda K, Kuriyama S, Hozawa A, Nakaya N, Shimazu T, Tsuji I. The joint impact of cardiovascular risk factors upon medical costs. Preventive Medicine, 44, 349-355, 2007.
Akhter M, Nishino Y, Nakaya N, Kurashima K, Sato Y, Kuriyama S, Tsubono Y, Tsuji I. Cigarette smoking and the risk of colorectal cancer among men: a prospective study in Japan. European Journal of Cancer Prevention, 16, 102-107, 2007.
Iijima K, Koike T, Abe Y, Inomata Y, Sekine H, Imatani A, Nakaya N, Ohara S, Shimosegawa T. Extensive gastric atrophy: an increased risk factor for superficial esophageal squamous cell carcinoma in Japan. American Journal of Gastroenterology, 102, 1・・・

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Iijima K, Koike T, Abe Y, Inomata Y, Sekine H, Imatani A, Nakaya N, Ohara S, Shimosegawa T. Extensive gastric atrophy: an increased risk factor for superficial esophageal squamous cell carcinoma in Japan. American Journal of Gastroenterology, 102, 1603-1609, 2007.
Shimazu T, Kuriyama S, Hozawa A, Ohmori K, Sato Y, Nakaya N, Nishino Y, Tsubono Y, Tsuji I. Dietary patterns and cardiovascular disease mortality in Japan: a prospective cohort study. International Journal of Epidemiology, 36, 600-609, 2007.
Hamaguchi T, Okamura H, Nakaya N, Abe K, Abe Y, Umezawa S, Kurihara M, Nakaya K, Yomiya K, Uchitomi Y. Survey of the current status of cancer rehabilitation in Japan. Disability and Rehabilitation,30,559-564,2008.
Takahashi H, Kuriyama S, Tsubono Y, Nakaya N, Fujita K, Nishino Y, Shibuya D, Tsuji I. Time spent walking and risk of colorectal cancer in Japan: The Miyagi Cohort Study. European Journal of Cancer Prevention, 16, 403-408, 2007.
Kakizaki M, Kuriyama S, Sato Y, Shimazu T, Matsuda-Ohmori K, Nakaya N, Fukao A, Fukudo S, Tsuji I. Personality and body mass index: A cross-sectional analysis from the Miyagi Cohort Study. Journal of Psychosomatic Research, 64, 71-80, 2008.
Saito-Nakaya K, Nakaya N, Akechi T, Inagaki M, Asai M, Goto K, Nagai K, Nishiwaki Y, Tsugane S, Fukudo S, Uchitomi Y. Marital status and non-small cell lung cancer survival: the Lung Cancer Database Project in Japan. Psychooncology, 17, 869-876.
Li XM, Li J, Tsuji I, Nakaya N, Nishino Y, Zhao XJ.Mass screening-based case-control study of diet and prostate cancer in Changchun, China. Asian Journal of Andrology,10,551-560,2008.
Niu K, Hozawa A, Awata S, Guo H, Kuriyama S, Seki T, Ohmori-Matsuda K, Nakaya N, Ebihara S, Wang Y, Tsuji I, Nagatomi R. Home blood pressure is associated with depressive symptoms in an elderly population aged 70 years and over: a population-based, cro・・・

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Niu K, Hozawa A, Awata S, Guo H, Kuriyama S, Seki T, Ohmori-Matsuda K, Nakaya N, Ebihara S, Wang Y, Tsuji I, Nagatomi R. Home blood pressure is associated with depressive symptoms in an elderly population aged 70 years and over: a population-based, cross-sectional analysis. Hypertension Research,31,409-416,2008.
Koizumi T, Nakaya N, Okamura C, Sato Y, Shimazu T, Nagase S, Niikura H, Kuriyama S, Tase T, Ito K, Tsubono Y, Okamura K, Yaegashi N, Tsuji I. Case-control study of coffee consumption and the risk of endometrial endometrioid adenocarcinoma. Eur J Cancer・・・

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Koizumi T, Nakaya N, Okamura C, Sato Y, Shimazu T, Nagase S, Niikura H, Kuriyama S, Tase T, Ito K, Tsubono Y, Okamura K, Yaegashi N, Tsuji I. Case-control study of coffee consumption and the risk of endometrial endometrioid adenocarcinoma. Eur J Cancer Prev 2008;17:358-63.
Niu K, Hozawa A, Guo H, Kuriyama S, Ebihara S, Yang G, Ohmori-Matsuda K, Nakaya N, Takahashi H, Fujita K, Wen S, Arai H, Tsuji I, Nagatomi R. Serum C-Reactive Protein Even at Very Low (<1.0 mg/l) Concentration Is Associated with Physical Performance in・・・

詳細を見る詳細を閉じる

Niu K, Hozawa A, Guo H, Kuriyama S, Ebihara S, Yang G, Ohmori-Matsuda K, Nakaya N, Takahashi H, Fujita K, Wen S, Arai H, Tsuji I, Nagatomi R. Serum C-Reactive Protein Even at Very Low (<1.0 mg/l) Concentration Is Associated with Physical Performance in a Community-Based Elderly Population Aged 70 Years and Over. Gerontology, 54, 260-267, 2008.
Kakizaki M, Inoue K, Kuriyama S, Sone T, Matsuda-Ohmori K, Nakaya N, Fukudo S, Tsuji I. Sleep duration and the risk of prostate cancer: the Ohsaki Cohort Study. British Journal of Cancer, 99, 176-178, 2008.
Kuriyama S,Shimazu T,Hozawa A,Kure S,Kurokawa N,Kakizaki M,Sone T,Matsuda-Ohmori K,Nakaya N,Satoh H,Tsuji I. No effect of the Trp64Arg variant of the β3-adrenergic receptor gene on weight loss by diet and exercise intervention among Japanese adults. Me・・・

詳細を見る詳細を閉じる

Kuriyama S,Shimazu T,Hozawa A,Kure S,Kurokawa N,Kakizaki M,Sone T,Matsuda-Ohmori K,Nakaya N,Satoh H,Tsuji I. No effect of the Trp64Arg variant of the β3-adrenergic receptor gene on weight loss by diet and exercise intervention among Japanese adults. Metabolism, 57, 1570-1575, 2008.
Li Q,Kakizaki M,Kuriyama S, Sone T, Yan H, Nakaya N, Mastuda-Ohmori K, Tsuji I. Green Tea Consumption and the Risk of Lung Cancer: The Ohsaki Study. British Journal of Cancer, 99, 1179-1184, 2008.
Kikuchi N, Ohmori-Matsuda K, Shimazu T, Sone T, Kakizaki M, Nakaya N, Kuriyama S, Tsuji I.Pain and Risk of Completed Suicide in Japanese Men: A Population-Based Cohort Study in Japan (Ohsaki Cohort Study).Journal of Pain Symptom and Management (in pres・・・

詳細を見る詳細を閉じる

Kikuchi N, Ohmori-Matsuda K, Shimazu T, Sone T, Kakizaki M, Nakaya N, Kuriyama S, Tsuji I.Pain and Risk of Completed Suicide in Japanese Men: A Population-Based Cohort Study in Japan (Ohsaki Cohort Study).Journal of Pain Symptom and Management (in press).
Kakizaki M, Kuriyama S, Sone T, Ohmori-Matsuda K, Hozawa A, Nakaya N, Fukudo S, Tsuji I. Sleep Duration and the Risk of Breast Cancer: The Ohsaki Cohort Study. British Journal of Cancer, 99, 1502-1505, 2008.
Li Q, Kakizaki M, Kuriyama S, Sone T, Yan H, Nakaya N, Mastuda-Ohmori K, Tsuji I.Green tea consumption and lung cancer risk: the Ohsaki study.British Journal of Cancer, 99, 1179-1184, 2008.
Arai S, Nakaya N, Kakizaki M, Ohmori K, Shimazu T, Kuriyama S, Fukao A, Tsuji I. Personality and Gastric Cancer Screening Attendance: A Cross-Sectional Analysis from the Miyagi Cohort Study. Journal of Epidemiology (In press).
Naganuma T, Kuriyama S, Kakizaki M, Sone T, Nakaya N, Ohmori-Matsuda K, Nishino Y, Fukao A, Tsuji I.Coffee Consumption and the Risk of Oral, Pharyngeal, and Esophageal Cancers in Japan: the miyagi cohort study. American Journal of Epidemiology, 168, 14・・・

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Naganuma T, Kuriyama S, Kakizaki M, Sone T, Nakaya N, Ohmori-Matsuda K, Nishino Y, Fukao A, Tsuji I.Coffee Consumption and the Risk of Oral, Pharyngeal, and Esophageal Cancers in Japan: the miyagi cohort study. American Journal of Epidemiology, 168, 1425-1432, 2008.
Kakuta Y, Nakaya N, Nagase S, Fujita M, Koizumi T, Okamura C, Niikura H. Ohmori K, Kuriyama S, Tase T, Ito K, Minami Y, Yaegashi N, Tsuji I. Case–control study of green tea consumption and the risk of endometrial endometrioid adenocarcinoma. Cancer Cau・・・

詳細を見る詳細を閉じる

Kakuta Y, Nakaya N, Nagase S, Fujita M, Koizumi T, Okamura C, Niikura H. Ohmori K, Kuriyama S, Tase T, Ito K, Minami Y, Yaegashi N, Tsuji I. Case–control study of green tea consumption and the risk of endometrial endometrioid adenocarcinoma. Cancer Causes Control (in press).
中谷直樹, 大森芳, 鈴木寿則, 寳澤篤, 栗山進一, 坪野吉孝, 辻一郎. がん検診の実施状況に関する市区町村実態調査. 日本公衆衛生雑誌, 51, 530-539, 2004.
濱口豊太, 中谷直樹、奈良進弘、赤松郁夫: 長期加療中脳卒中患者の心理的ストレス状況と筋弾性との関連. 新潟医療福祉大学紀要, 3, 77-82, 2003.
小泉弥生, 粟田主一, 関徹, 中谷直樹, 栗山進一, 鈴木寿則, 大森芳, 寳澤篤, 海老原覚, 荒井啓行, 辻一郎. 都市在住の高齢者におけるソーシャル・サポートと抑うつ症状の関連性. 日本老年医学会雑誌, 41, 426-433, 2004.
佐藤文美, 島津太一, 栗山進一, 大森芳，中谷直樹, 辻一郎，荒井陽一. 日本における魚摂取と前立腺癌罹患に関する前向きコホート研究. 日本泌尿器科学会雑誌, 99, 14-21, 2008.

DOI： 10.5980/jpnjurol1989.99.14 　
Higashiguchi M, Nakaya N, Ohmori K, Shimazu T, Sone T, Hozawa A, Kuriyama S, Tsuji I.Malnutrition and the risk of long-term care insurance certification or mortality. A cohort study of the Tsurugaya project.Nippon Koshu Eisei Zasshi 2008;55:433-9. (Jap・・・

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Higashiguchi M, Nakaya N, Ohmori K, Shimazu T, Sone T, Hozawa A, Kuriyama S, Tsuji I.Malnutrition and the risk of long-term care insurance certification or mortality. A cohort study of the Tsurugaya project.Nippon Koshu Eisei Zasshi 2008;55:433-9. (Japanese)
Nakaya N, Tsubono Y, Hosokawa T, Nishino Y, Ohkubo T, Hozawa A, Shibuya D, Fukudo S, Fukao A, Tsuji I, Hisamichi S. Personality and the risk of cancer. Journal of the National Cancer Institute, 95, 799-805, 2003.
Nakaya N, Kurashima K, Yamaguchi J, Ohkubo T, Nishino Y, Tsubono Y, Shibuya D, Fukudo S, Fukao A, Tsuji I, Hisamichi S. Alcohol consumption and mortality in Japan: the Miyagi Cohort Study. Journal of Epidemiology, 14 (Suppl 1), S18-S25, 2004.
Nakaya N, Kumano H, Minoda K, Kanazawa M, Fukudo S. Laterality and imbalance of muscle stiffness related to personality. Behavioral Medicine, 30, 5-9, 2004.
Nakaya N, Kumano H, Minoda K, Koguchi T, Tanouchi K, Kanazawa M, Fukudo S. Psychological effects of the muscle relaxation on juvenile delinquents: Preliminary Study. International Journal of Behavioral Medicine, 11, 176-180, 2004.
Nakaya N, Tsubono Y, Hosokawa T, Hozawa A, Fukudo S, Tsuji I. Personality and the risk of ischemic heart disease and stroke. Clinical and Experimental Hypertension, 2&3, 301-309, 2005.
Nakaya N, Tsubono Y, Kuriyama S, Hozawa A, Shimazu T, Kurashima K, Fukudo S, Shibuya D, Tsuji I. Alcohol consumption and the risk of cancer in Japanese men: The Miyagi Cohort Study. European Journal of Cancer Prevention, 14, 169-174, 2005.
Nakaya N, Fukudo S, Akizuki N, Yoshikawa E, Kobayakawa M, Fujimori M, Shimizu K, Nagai K, Nishiwaki Y, Uchitomi Y. Twenty-four-hour urinary cortisol levels before complete resection of non-small cell lung cancer and survival. Acta Oncologica, 44, 399-4・・・

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Nakaya N, Fukudo S, Akizuki N, Yoshikawa E, Kobayakawa M, Fujimori M, Shimizu K, Nagai K, Nishiwaki Y, Uchitomi Y. Twenty-four-hour urinary cortisol levels before complete resection of non-small cell lung cancer and survival. Acta Oncologica, 44, 399-405, 2005.
Nakaya N, Tsubono Y, Nishino Y, Hosokawa T, Fukudo S, Shibuya D, Akizuki N, Yoshikawa E, Kobayakawa M, Fujimori M, Saito-Nakaya, K, Uchitomi Y, Tsuji I. Personality and survival from cancer. British Journal of Cancer, 92, 2089-2094, 2005.
Nakaya N, Goto K, Saito-Nakaya K, Inagaki M, Otani T, Akechi T, Nagai K, Hojo F, Uchitomi Y, Tsugane S, Nishiwaki Y. The Lung Cancer Database Project at the National Cancer Center, Japan. Japanese Journal of Clinical Oncology, 36, 280-284, 2006.
Nakaya N, Saito-Nakaya K, Akizuki N, Yoshikawa E, Kobayakawa M, Fujimori M, Nagai K, Nishiwaki Y, Fukudo S, Tsubono Y, Uchitomi Y. Depression and survival from non-small cell lung cancer after curative resection: preliminary study. Cancer Science, 97, ・・・

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Nakaya N, Saito-Nakaya K, Akizuki N, Yoshikawa E, Kobayakawa M, Fujimori M, Nagai K, Nishiwaki Y, Fukudo S, Tsubono Y, Uchitomi Y. Depression and survival from non-small cell lung cancer after curative resection: preliminary study. Cancer Science, 97, 199-205, 2006.
Nakaya N, Hansen PE, Schapiro IR, Eplov LF, Saito-Nakaya K, Uchitomi Y, Johansen C. Personality traits and Cancer Survival: A Danish cohort study. British Journal of Cancer, 95, 146-152, 2006.
Nakaya N, Kikuchi N, Shimazu T, Ohmori K, Kakizaki M, Sone T, Awata S, Kuriyama S, Tsuji I. Alcohol Consumption and Suicide Mortality among Japanese Men: The Ohsaki Study. Alcohol, 41, 503-510, 2007.
Nakaya N, Saito-Nakaya K, Akechi T, Kuriyama S, Inagaki M, Kikuchi N, Nagai K, Tsugane S, Nishiwaki Y, Tsuji I, Uchitomi Y. Negative Psychological Aspects and Survival in Lung Cancer Patients. Psycho-Oncology, 17, 466-73, 2008.

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書籍等出版物 19

中谷直樹. 心理社会的要因とがん発症・生存に関する最新データ. 緩和ケア, 23, pp217, 2013.(総説)

中谷直樹
Daisuke Nishi, Yuichi Koido, Naoki Nakaya, Toshimasa Sone, Hiroko Noguchi, Kei Hamazaki, Tomohito Hamazaki, Yutaka Matsuoka. PTSD and the Attenuating Effects of Fish Oils: Results of Supplementation After the 2011 Great East Japan Earthquake (Chapter 16).
中谷直樹. 飲酒と自殺に関する前向きコホート研究ー大崎コホート研究ー.日本アルコール関連問題学会雑誌 13, 32-34, 2011
中谷直樹. 罹患・生存と心理社会的問題. 内富庸介、小川朝生 (編). 臨床精神腫瘍学. 医学書院, 東京, pp25-36, 2011
中谷直樹, 福土審. 各臓器別にみた心身症: ②消化器－胃・十二指腸潰瘍. 久保千春 (編). 心身医療実践マニュアル－知っておきたい臨床医の基本. 文光堂, 東京, pp200-206, 2003. (著書)
中谷直樹, 福土審. 各臓器別にみた心身症: ②消化器－過敏性腸症候群. 久保千春 (編). 心身医療実践マニュアル－知っておきたい臨床医の基本. 文光堂, 東京, pp195-199, 2003. (著書)
中谷直樹, 福土審. サイコオンコロジー: がんの病前性格. 保坂隆 (編). 現代のエスプリ. 至文堂, 東京, pp53-62, 2003. (総説)
中谷直樹, 坪野吉孝. がんの病前性格. 医学のあゆみ, 206, pp878-879, 2003.(総説)
中谷直樹, 坪野吉孝, 細川徹, 西野善一, 大久保孝義, 寳澤篤, 渋谷大助, 福土審, 深尾彰, 辻一郎, 久道茂. パーソナリティとがん罹患に関する前向きコホート研究. 心身医学, 44, pp471-477, 2004.(総説)
中谷直樹, 内富庸介. Mebio Oncology, 2, pp116-117, 2005. (Kissane DW, et al. Effect of cognitive-existential group therapy on survival in early-stage breast cancer. Journal of Clinical Oncology, 22, 4255-5260, 2004.).(解説)
中谷直樹, 清水研, 大庭章, 内富庸介, 坪野吉孝. サイコオンコロジーと心身医療－がんと疫学－. 心療内科, 9, pp95-100, 2005.(総説)
中谷直樹, 辻一郎：わが国におけるがん検診の現状と問題点－地域格差．クリニカルプラクティス, 25, pp245-249, 2006.(総説)
中谷直樹. 疾病誘発パーソナリティ.日本応用心理学会 (編): 応用心理学事典, 丸善, 東京, pp270-271, 2007.(著書)
中谷直樹. 心理社会的要因とがん罹患／生存 -パーソナリティを中心として-. 腫瘍内科, 1, pp383-388, 2007.(総説)
中谷直樹, 内富庸介. ストレスとがん罹患に関する疫学研究. ストレス科学研究,23,pp1-7,2008.(総説)
中谷直樹,中谷久美. がん患者のサバイバーシップ；社会的問題（退職・未就労リスク及び離婚リスク）. 腫瘍内科, 5, 122-130, 2010.(総説)
中谷直樹, 中谷久美. 心理社会的要因とがん罹患/生存. 大西秀樹 (編). 専門医のための精神科臨床リュミエール24, サイコオンコロジー. 中山書店, 東京,pp26-37.(著書)
中谷直樹、中谷久美、中村好一、辻一郎．デンマークにおける保健医療データベースに関する調査研究．公衆衛生,75(2)，医学書院,pp160-163, 2011.
中谷直樹. 心理的要因ががん発症・がん予後に与える影響. がん医療に携わるすべての医師のための心のケアガイド.真興交易㈱医書出版部,東京.pp211-218,2011.(著書)

︎全件表示 ︎最初の5件までを表示

講演・口頭発表等 51

Naoki Nakaya. Adverse health effects due to spousal diseases/long-term care certification and the intervention strategies The 8th Asia Pacific Occupational Therapy Congress 2024, Scientific workshop, Sapporo, Nobember, 2024
東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査（宮城）の概要. 中谷直樹、小暮真奈、畑中里衣子、菅野郁美、中谷久美、小原拓、中村智洋、宇留野晃、布施昇男、泉陽子、丹野高三、辻一郎、栗山進一、呉繁夫、寳澤篤. 第80回日本公衆衛生学会総会. オンライン開催, 12月, 2021年.
中谷直樹．東北メディカル・メガバンク計画・地域住民コホート調査：健康行動学的側面の結果及び今後の展開．日本行動医学会学術総会，オンライン開催，11月，2021（シンポジウム）
Partners’ ongoing treatment for chronic disease and the risk of psychological distress after the Great East Japan Earthquake.Naoki Nakaya, Akira Narita, Naho Tsuchiya, Tomohiro Nakamura, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita. 21st World Congress of
中谷直樹、成田暁、中村智洋、土屋菜歩、小暮真奈、丹野高三、坂田清美、菊谷昌浩、高井貴子、菅原準一、栗山進一、辻一郎、呉繁夫、寳澤篤.性・年齢階級別にみた東日本大震災後の平均歩数：地域住民コホート調査．第66回東北公衆衛生学会、福島市、7月、2017年（一般口演）
中谷直樹、中村智洋、土屋菜歩、成田暁、小暮真奈、丹野高三、佐々木亮平、高梨信之、坂田清美、富田博秋、菊谷昌浩、菅原準一、栗山進一、辻一郎、呉繁夫、寳澤篤．東日本大震災後の沿岸部と内陸部の慢性疾患の治療中断割合の比較．第27回日本疫学会総会，甲府，1月，2017年（ポスター発表）．
中谷直樹、中村智洋、土屋菜歩、成田暁、小暮真奈、丹野高三、佐々木亮平、坂田清美、富田博秋、菊谷昌浩、菅原準一、栗山進一、辻一郎、呉繁夫、寳澤篤. 沿岸部居住者における東日本大震災後の新規うつ病・PTSD罹患リスク.第75回日本公衆衛生学会、大阪市、10月、2016年（一般口演）
中谷直樹、中村智洋、土屋菜歩、成田暁、辻一郎、寳澤篤、富田博秋．東日本大震災1年後沿岸部被災地における心理的苦痛と高血圧治療中断関連：七ヶ浜健康増進プロジェクト．第52回日本循環器病予防学会、さいたま市、6月、2016年（一般口演）
中谷直樹、中村智洋、土屋菜歩、成田暁、辻一郎、寳澤篤、富田博秋．震災1年後の将来の住居の見通しと心理的苦痛リスクの関連．第65回東北公衆衛生学会, 山形市,7月,2016年（一般口演）
中谷直樹．東日本大震災の心身への影響：東北メディカル･メガバンク計画．第57回日本心身医学会総会ならびに学術講演会、仙台市、6月、2016年（市民公開講座）
中谷直樹, 中村智洋, 辻一郎, 寳澤篤, 富田博秋. 東日本大震災の被災地における慢性疾患治療と就労の関連：七ヶ浜健康増進プロジェクト．日本公衆衛生学会総会、宇都宮市、11月、2014年（口頭発表）
中谷直樹、中村智洋、土屋菜歩、成田暁、菊谷昌浩、小原拓、清元秀泰、栗山進一、辻一郎、呉繁夫、寳澤篤、丹野高三、佐々木亮平、坂田清美．震災関連要因と慢性疾患の治療中断の関連：地域住民コホート調査．第26回日本疫学会学術総会、米子市、1月、2016年（ポスター発表）
中谷直樹、中村智洋、土屋菜歩、成田暁、小暮真奈、中谷純、峯岸直子、布施昇男、鈴木洋一、菅原準一、菊谷昌浩、富田博秋、清元秀泰、栗山進一、辻一郎、呉繁夫、山本雅之、寳澤篤．東日本大震災後の宮城県沿岸部における治療中断東北メディカル・メガバンク事業：地域住民コホート調査．宮城県公衆衛生学会,仙台,6月,2015（口頭発表）
Nakaya N, Nakamura T, Tsuchiya N, Kogure M, Tanno K, Sasaki R, Sakata K, Nakaya J, Minegishi N, Fuse N, Suzuki Y, Sugawara J, Kikiuya M, Tomita H, Kiyomoto H, Kuriyama S, Tsuji I, Yaegashi N, Yamamoto Y, Hozawa A. Comparison of the mental issues of co
中谷直樹．埼玉がんリハビリテーション研究会．心理社会的要因とがんの罹患／生存，大宮，2月，2015（基調講演）．
中谷直樹、土屋菜歩、中谷久美、成田暁、平田匠、中村智洋、小暮真奈、小原拓、菅原準一、栗山進一、辻一郎、呉繁夫、寳澤篤. 配偶者の主観的健康観と自身の抑うつ症状との関連：東北メディカル・メガバンク計画・地域住民コホート調査. 第29回日本疫学会学術総会、東京、1月、2019（ポスター発表）.
中谷直樹、中村智洋、辻一郎、富田博秋．慢性疾患治療者の心理的苦痛に関する研究：七ヶ浜健康増進プロジェクト．日本疫学会総会，仙台，1月，2014（ポスター発表）
中谷直樹, 中村智洋, 辻一郎, 寳澤篤, 富田博秋. 慢性疾患治療者の心理的苦痛に関する研究：七ヶ浜健康増進プロジェクト. 日本公衆衛生学会総会, 津, 10月, 2013（口頭発表）
中谷直樹, 心理社会的因子とがん発症・がん予後に関する疫学研究及び今後の展開. 日本サイコオンコロジー学会総会, 9月, 2013 (シンポジウム)
中谷直樹．がんに影響を及ぼす心理社会的要因の検討．日本疫学会総会,大阪,1月,2013 (奨励賞受賞講演)．
中谷直樹, 菊谷昌浩, 中谷純, 清元秀泰, 菅原準一, 富田博秋, 長神風二, 大隅典子, 栗山進一, 辻一郎, 寳澤篤. 東北メディカル・メガバンク事業：山元町における住民意識調査. 日本疫学会総会,大阪,1月,2013 (ポスター発表).
中谷直樹、中村智洋、土屋菜歩、平田匠、成田暁、小暮真奈、後岡広太郎、丹野高三、坂田清美、小原拓、菅原準一、栗山進一、辻一郎、呉繁夫、寳澤篤．東日本大震災の被災地住民における平均歩数の変化：地域住民コホート調査．第77回日本公衆衛生学会総会、郡山市、10月、2018年（口頭発表）
中谷直樹、根本晴美、Carine J. Yi、佐藤文子、新宮古都美、庄子朋香、佐藤翔輔、土屋菜歩、中村智洋、成田暁、小暮真奈、菅原由美、兪志前、Nicole Gunawansa、栗山進一、村尾修、佐藤健、今村文彦、辻一郎、寳澤篤、富田博秋．東日本大震災による津波避難訓練の有効性．第54回宮城県公衆衛生学会学術総会、仙台、7月、2018年（口頭発表）．
中谷直樹、成田暁、中村智洋、土屋菜歩、小暮真奈、丹野高三、坂田清美、菊谷昌浩、高井貴子、菅原準一、栗山進一、辻一郎、呉繁夫、寳澤篤．東日本大震災の被災者における高い平均歩数と関連する要因：地域住民コホート調査．第28回日本疫学会学術総会、福島市、2月、2018年（ポスター発表）
中谷直樹、成田暁、中村智洋、土屋菜歩、小暮真奈、丹野高三、坂田清美、菊谷昌浩、高井貴子、菅原準一、栗山進一、辻一郎、呉繁夫、寳澤篤.地域住民コホート調査における家屋の被害の程度と平均歩数の関連.第76回日本公衆衛生学会総会、鹿児島市、10月、2017年（口頭発表）
中谷直樹, 中谷久美, Bidstrup PE, Dalton SO, Frederiksen K, Steding-Jessen M, 内富庸介, Johansen C. 乳がん患者における男性パートナーのうつ病リスク. 日本疫学会総会,東京,1月,2012 (ポスター発表).
Nakaya N, Kumano H, Minoda K, Fukudo S: Imbalance of Muscle Tension Closely Relates to Personality and Stress Response. The 6th International Congress of Behavioral Medicine, Brisbane, November, 2000.
Nakaya N, Saito K, Kurashima K, Hozawa A, Kanazawa M, Fukudo S, Tsuji I. Increased Risk of Irritable Bowel Syndrome in Depressive Individuals in Elderly Population. The 104th American Gastroenterological Association, Orlando, May, 2003.
Nakaya N, Tsubono Y, Hosokawa T, Nishino Y, Ohkubo T, Hozawa A, Shibuya D, Fukudo S, Fukao A, Tsuji I, Hisamichi S. Personality and the risk of ischemic heart disease and cerebrovascular disease. The 5th Japanese Annual Conference on Chronocardiology a・・・

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Nakaya N, Tsubono Y, Hosokawa T, Nishino Y, Ohkubo T, Hozawa A, Shibuya D, Fukudo S, Fukao A, Tsuji I, Hisamichi S. Personality and the risk of ischemic heart disease and cerebrovascular disease. The 5th Japanese Annual Conference on Chronocardiology and Hypertension, Sapporo, September, 2003.
Nakaya N, Tsubono Y, Hosokawa T, Fukudo S, Tsuji I. Personality and the risk of cancer. The 7th World Congress of Psycho-Oncology, Copenhagen, August, 2004.
Nakaya N, Tsubono Y, Nishino Y, Hosokawa T, Fukudo S, Shibuya D, Akizuki N, Yoshikawa E, Kobayakawa M, Fujimori M, Uchitomi Y, Tsuji I. Personality and survival from cancer. The 18th World Congress on Psychosomatic Medicine, Kobe, August, 2005.
Nakaya N, Saito-Nakaya K, Bidstrup PE, Dalton SO, Frederiksen K, Steding-Jessen M, Uchitomi Y, Johansen C. Risk of affective disorders after spouse's breast cancer diagnosis. The 11th World Congress on Psycho-Oncology, Vienna, June, 2009.
中谷直樹, 熊野宏昭, 美野田啓二. アローバランスグラフの信頼性及び心理的質問票との関連性について. 第40回日本心身医学会総会,弘前,6月,1999.
中谷直樹, 熊野宏昭, 美野田啓二, 福士審: 筋骨格系の歪みとパーソナリティ及び心理的ストレス反応との関連の検討. 日本心身医学会東北地方会,盛岡,9月,1999.
中谷直樹, 熊野宏昭, 美野田啓二, 福土審. アローバランスグラフの信頼性及び妥当性の検討.日本行動療法学会第25回大会,10月,東京,1999.
中谷直樹, 熊野宏昭, 美野田啓二, 福土審. 筋緊張と心理面との関連―左右差及び局所の状態の重要性―. 日本心身医学会東北地方会,仙台,3月,2000.
中谷直樹, 熊野宏昭, 美野田啓二, 福土審. 筋弾性及びその左右のバランスとパーソナリティ及び心理的ストレス反応との関連,日本心身医学会総会, 東京, 6月, 2000.
中谷直樹, 熊野宏昭, 美野田啓二, 田之内厚三, 福土審. 少年院入院者に対するリラクセーション効果. 麻布大学環境科学研究会,神奈川,9月,2000.
中谷直樹, 熊野宏昭, 美野田啓二, 古口高志, 田之内厚三, 金澤素, 福土審. 少年院入院者に対するリラクセーションによる心理的変化,日本心身医学会総会,鹿児島,5月,2001.
中谷直樹, 坪野吉孝, 西野善一, 辻一郎, 渋谷大助, 福土審, 久道茂. アルコールとがん罹患に関する前向きコホート研究,日本疫学会総会,東京,1月,2002.
中谷直樹, 坪野吉孝, 西野善一, 辻一郎, 渋谷大助, 福土審, 久道茂. パーソナリティとがん罹患に関する前向きコホート研究,日本心身医学会総会,東京,5月,2002.
中谷直樹, 坪野吉孝, 西野善一, 辻一郎, 渋谷大助, 福土審, 久道茂. 飲酒と全死因死亡に関する前向きコホート研究,東北公衆衛生学会,青森,8月,2002.
中谷直樹, 坪野吉孝, 西野善一, 辻一郎, 渋谷大助,福土審, 久道茂. パーソナリティと虚血性心疾患及び脳血管疾患に関する前向きコホート研究,日本疫学会総会,福岡,1月,2003.
中谷直樹, 坪野吉孝, 西野善一, 辻一郎, 渋谷大助, 福土審, 久道茂. パーソナリティと虚血性心疾患及び脳血管疾患に関する前向きコホート研究,日本心身医学会東北地方会,仙台,2月,2003.
中谷直樹, 藤田和樹, 寳澤篤, 小泉弥生, 大森芳, 倉嶋佳誉子, 粟田主一, 福土審, 辻一郎. 高齢者における過敏性腸症候群及び機能性消化管障害の抑うつ症状とQuality of Life,日本老年精神医学会,名古屋,6月,2003.
中谷直樹, 坪野吉孝, 西野善一, 辻一郎, 渋谷大助, 福土審, 久道茂. パーソナリティとがん罹患に関する前向きコホート研究. 日本心身医学会総会,沖縄,5月,2003. (シンポジウム)
中谷直樹, 大森芳, 鈴木寿則, 寳澤篤, 栗山進一, 坪野吉孝, 辻一郎. がん検診の実施状況に関する市区町村実態調査,日本疫学会総会,山形,1月,2004.
中谷直樹, 坪野吉孝, 西野善一, 細川徹, 福土審, 渋谷大助, 秋月伸哉, 吉川栄省, 小早川誠, 藤森麻衣子, 内富庸介, 辻一郎. パーソナリティとがん予後に関する前向きコホート研究, 東北公衆衛生学会,盛岡,7月,2006.
中谷直樹, 菊地信孝, 島津太一, 大森芳, 柿崎真沙子, 曽根稔雅, 粟田主一, 栗山進一, 辻一郎. 飲酒と自殺に関する前向きコホート研究ー大崎コホート研究ー.日本疫学会総会,広島,1月,2007.
中谷直樹, 中谷久美, 明智龍男, 栗山進一, 稲垣正俊, 菊地信孝, 永井完治, 津金昌一郎, 西脇裕, 辻一郎, 内富庸介. 肺がん患者の否定的な心理状態と予後に関する前向きコホート研究. 日本疫学会総会,東京,1月,2008.
中谷直樹, 菊地信孝, 島津太一, 大森芳, 柿崎真沙子, 曽根稔雅, 粟田主一, 栗山進一, 辻一郎. 飲酒と自殺に関する前向きコホート研究ー大崎コホート研究ー.日本アルコール関連問題学会,神戸,7月,2010. (シンポジウム)

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共同研究・競争的資金等の研究課題 17

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尿中ナトリウム、カリウム、ナトリウムカリウム比の関連がんの解明と方策の検討

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2023年4月1日～ 2027年3月31日

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本研究の目的はがん診療連携拠点病院において統合失調症を有する患者とそうではない患者とを比較し、がん診断時のステージ、侵襲的治療を受けた割合、がん治療の質とされる標準的治療を受けた割合に差があるかどうかを明らかにすることである。本研究では、大学病院をはじめとしたがん診療連携拠点病院を対象として各施設で院内がん登録情報とDPCデータおよびレセプトデータを突合し、解析用データシートの提供を受けてこれを明らかにする。今年度は岡山大学病院と島根大学医学部附属病院との2施設でのパイロット調査を計画し、倫理委員会で承認された。2施設において院内がん登録情報の利用申請を行い、承認を得た。岡山大学病院においては院内がん登録情報と電子カルテ情報を突合し、解析用のデータシートの提供を受けて現在解析中である。島根大学医学部附属病院においても、院内がん登録情報と電子カルテ情報との突合に向けた相談を担当部署と進め、実施可能性の検討と実施に向けての障壁が確認できた。
行政データを利活用して精神障害者のがん検診受診格差を地域単位で明らかにする研究

藤原雅樹, 稲垣正俊, 中谷直樹

2023年4月1日～ 2027年3月31日

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本研究は、自治体のデータを利活用し、精神障害者のがん検診受診率について一般住民との格差の動向を明らかにするとともに、精密検査の受診格差の有無を明らかにする。今年度は、先行して行っていた、岡山市から提供を受けた2019年度、2020年度のがん検診の解析用データベースを解析した結果を査読付き英文誌において公表した。2019年度（covid-19流行前）がん検診受診数に対する、2020年度（covid-19流行下）のがん検診受診者数の増減率を、重度精神障害と一般人口で算出した。結果、どちらの集団でもcovid-19流行前後で、がん検診受診者が減少していたが、重度精神障害者はがん検診の受診者数の減少率が大きいことが示唆された。現在は、2021年度がん検診の解析用データセットも加えて、がん検診受診および精密検査の受診行動の解析を準備している。
過敏性腸症候群発症の関連要因および家族集積性に関する大規模前向きコホート研究

中谷久美, 寳澤篤, 中谷直樹, 福土審

2023年4月1日～ 2026年3月31日

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本研究の目的は、TMM計画地域住民コホート調査で以下の検討を行うことである。【研究1】IBS有病および発症とその関連要因の検討 (約16,000人規模での検討)、【研究2】IBSの家族集積性およびその関連要因の検討 (親子・夫婦約5,000ペア)によりIBS発症に関連する要因の因果の検証を含めた検討、また、家族で共有する環境要因の影響の検討が可能である。【研究1】【研究2】を2023年度に開始した。【研究1】については、TMM計画地域住民コホート調査のベースライン調査参加者を対象にIBS有病に関連する要因の検討を行い、IBS有病と関連する要因として、年齢、震災での被災の程度、教育歴、歩行時間、主観的ストレス、心理的苦痛、うつが示された。中でも心理的要因である主観的ストレス、心理的苦痛、うつは、男女とも、また、全ての年齢階層で有意な関連を示し、IBSの病態において重要な要因である可能性が示唆された。本研究結果に関する論文はJournal of Neurogastroenterology and Motility誌に受理されている。また、追跡調査に参加した約16,000人を対象にIBS発症とその関連要因を検討するため、解析用データの構築を行った。今後、IBS発症に関連する要因を性、年齢などの基本情報に加え生活習慣、心理・社会的要因、健康状態、震災影響、生理指標の変数を用いて検討する。前向きコホートにより、関連要因の因果の検証が可能となる。【研究2】については、約5,000組の親子および夫婦のIBS有病・発症の一致性を比較検討するためのデータの構築準備および文献検索を行った。親子のみならず夫婦も検討に含めることでIBS発症における共有環境の影響がより明確となる。本研究によりIBS発症の関連要因および因果の検証、生活習慣や環境の影響の明確化によるIBSの病態解明を目指す。
大規模配偶者ペアを用いた健検診受診行動の解明と介入方法の開発

中谷直樹, 中谷久美, 曽根稔雅

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2023年4月1日～ 2026年3月31日

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本研究では夫婦関係を同定した大規模疫学データ（5,000組以上の夫婦ペア）を利用して、以下の3点の研究疑問を検証する。（研究１）健検診受診行動は夫婦で一致するか？（研究２）健検診受診行動に影響する要因は何か？（研究３）自身の心理的苦痛のインパクトは、配偶者あるいは自分の疾病どちらが影響するか？の3点である。予想される結果として、（研究１）両者の一致度は高く、年齢とともに一致度は高くなる。（研究２）自身の健検診受診行動に与える要因自身の要因：年齢、心理的苦痛、抑うつ症状、教育歴、疾患既往歴（Charlson index）生活習慣（喫煙、飲酒、運動）、子どもの人数、就業配偶者の要因：健検診受診行動、心理的苦痛、抑うつ症状などである。（研究３）配偶者の慢性疾患の方が自身の心理的苦痛に与えるインパクトが大きい。 R5年度は夫婦の健検診受診行動に関するレビューを行い、3件で配偶者が大腸がん検査を受けている場合、本人が大腸がん検査を受けるのが有意に高いことが示された。この3件の共変量や解析手法等を精査し、ある一定の本研究の分析計画を決定した。大腸がんに焦点を当てた分析を実施し、夫が大腸がん検診受診あり者で、妻も大腸がん検診受診を受診したオッズ比は約3倍だった。この関連は、夫の年齢や夫婦の就業状況によって変化しなかった。
社会的ケアを要する高齢者の在宅生活維持に資するQOL規定因子の実証的解明

中村裕美, 森山葉子, 白岩健, 森川美絵, 京極真, 中谷直樹

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Saitama Prefectural University

2020年4月1日～ 2025年3月31日

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2021（令和3）年度には、３つのプロジェクトを遂行してきた。１つ目は、社会的ケア関連QoL尺度のイラスト版(The Adult Social care Outcomes Toolkit-Easy Read version)日本語版の構築であった。この版は、文字情報のみの質問紙という手段で調査することに限界のある認知や言語表出に問題を抱える人々を、評価の主体に組み込む仕組みである。このイラスト版を、日本人の審美眼に叶うようイラストレーターを雇用し、オリジナルのイラストを起こしてきた。原版開発チームとの協議により、2021年度はそのイラストが確定できた。２つ目のプロジェクトは、介護保険を利用する家族を支援する介護者（ケアラー）版質問紙（the Adult Social Care Outcomes Toolkit for Carer)の日本語版の信頼性と妥当性を検証し、国際学術誌で公刊することであった。３つ目のプロジェクトは、介護保険を利用しつつ在宅生活を営む人と、その家族介護者100組を対象とした、前向きコホート研究である。これまでに我々が開発してきた質問紙（要介護者版と家族介護者版）を用いて、訪問リハビリテーションの機会を捉えて、ベースラインと、６カ月のデータ取集を行ってきた。上記質問紙に加えて、客観的指標として、握力、認知機能、日常生活自立度、活動量を測定してきた。2021年度には、ベースライン42ペア、６カ月地点で２ペアのデータを取得できている。このプロジェクトでは100ペアを１年間追跡することとしている。
大規模公的データバンクを利用した配偶者ペアの生活習慣・健康指標の一致性と介入展開

中谷直樹, 土屋菜歩

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

2020年4月1日～ 2023年3月31日

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これまで申請者（中谷）は、5,000を超える配偶者ペアの大規模データベースを用い、配偶者同士の生活習慣（喫煙、飲酒、身体活動）が統計学的に有意に一致したことを報告した。本研究では、研究の新しい視点として、以下の2点を解明する；① 男女のランダムペアと比較しても、配偶者同士の生活習慣の一致性が高いのか？② 片方の配偶者が生活習慣を修正した時、もう片方の配偶者も同様に修正するのか？この2点を解明することで、配偶者同士の環境要因の重要性が明らかになり、また配偶者双方に向けた効率的・効果的な生活習慣の変容プログラムの開発を試みる。①については、2021年度中にデータセット作成、データ分析、論文化まで終了し、現在論文投稿中である。結果としては、配偶者同士と比べてランダム男女ペア（夫婦と同じ年齢のペア）では男女ペアの相関が極めて低く、オッズ比も低値を示した。
大規模コホート調査における配偶者のがん既往がパートナーに及ぼす健康影響

中谷直樹

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

2017年4月1日～ 2021年3月31日

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本研究では一般地域住民を対象とした横断研究デザインにより、配偶者の慢性疾患既往歴（主要疾患の有無、主要疾患の個数）、主観的健康観と本人の精神・心理的状態（抑うつ症状、心理的苦痛、不眠）の関連について分析した。その結果、配偶者の慢性疾患既往歴と本人の精神・心理的状態（抑うつ症状、心理的苦痛、不眠）の関連は示されなかった。一方、配偶者の主観的健康観「良好群」に対する「不良群」の本人の抑うつ症状有りのオッズ比は、1.2と有意に高かった（p=0.02）。この関連は、本人が女性オッズ比が1.3、また、本人の年齢64歳以下の者のオッズ比が1.3と有意な関連が示された。
要介護者の配偶者における要介護・死亡リスクに関する縦断的研究

曽根稔雅, 遠又靖丈, 中谷直樹

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku Fukushi University

2016年4月1日～ 2020年3月31日

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本研究の目的は、要介護者の配偶者における、健康（心理的苦痛、死亡）及び社会的側面（社会活動）への影響を明らかにすることである。また、これらの影響について要介護者の要介護度別に検討することである。その結果、配偶者が要介護状態にない者に比べ、配偶者が要介護状態の者において、心理的苦痛が高く、社会的活動の参加頻度が低く、死亡リスクが高いことが示された。また、この結果は、要介護者の要介護度による影響を受けないことが示された。
東日本大震災後の夫婦における生活習慣と疾患の共有度および健康影響の同定

土屋菜歩, 中谷直樹, 中谷久美, 濱口豊太

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2016年4月1日～ 2019年3月31日

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本研究の目的は「東日本大震災後の夫婦は、生活習慣および疾患を共有しているか」を検証することである。本研究では東北メディカル・メガバンク事業地域住民コホート調査のデータを用いた。調査参加者約50,000名の情報からデータベースを構築し、5,758組の夫婦を同定して解析を行った。夫婦の平均年齢（標準偏差）は夫で63.2(10.5)歳、妻で60.4(10.2)歳であった。塩分摂取に関する食習慣を夫婦で共有しており、年齢階級により食習慣の一致度が異なっていることが明らかになった。配偶者が生活習慣病を持たない場合に対し、配偶者がそれらを有すると疾患を有するリスクは有意に高いことが明らかになった。
破局的ストレス下の慢性疾患患者における心理的・社会的側面、生活習慣及び震災影響

中谷直樹, 寳澤篤, 富田博秋, 土屋菜歩, 中村智洋

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (C)

研究機関：Tohoku University

2014年4月1日～ 2017年3月31日

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本研究では、東日本大震災のデータを用いて、慢性疾患患者（脳卒中、心筋梗塞・狭心症、腎臓病、肝臓病、がん、高血圧、糖尿病、高コレステロール血症）の心理的・社会的側面、生活習慣、震災影響を明らかにすることで、慢性疾患患者に対するサポートの必要性を検証した。結果として、慢性疾患患者は非患者に比し有意に高い心理的負担を有していることが明らかになった。慢性疾患患者は、心理的負担が高いと想定される被災者の中でもより高い心理的負担感を示しており、慢性疾患患者に対する身体的ケアのみならず心理的サポートの必要性が改めて示された。
ω3系脂肪酸と集団認知行動療法によるうつ状態の増悪予防法の開発

調漸, 岡村尚昌, 田山淳, 濱崎景, 中谷直樹, 曽根稔雅, 林田雅希, 小川豊太

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Scientific Research (B)

研究機関：Nagasaki University

2013年4月1日～ 2017年3月31日

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本研究目的は，ω3系脂肪酸とpsychoeducation（PE）のコンビネーションが軽度・中程度のうつの改善に寄与するという仮説検証である。軽度・中程度のうつを有する者76名を対象としたω3系脂肪酸とPE介入群（強化介入群）とプラセボとPE介入群（通常介入群）のいずれかに無作為に割り付けた。3ヶ月の介入の結果，BDI-IIではANCOVAで有意な値は得られなかった（p=0.30, net change 0.7 (-0.7, 2.1）が，両群でBDI-IIの値が介入により有意に低下した。両群に実施したpsychoeducationの効果が強かった可能性がある。
がん患者の配偶者における健康影響に関する縦断的研究

中谷直樹, 大庭章, 長谷川涼子

提供機関：Japan Society for the Promotion of Science

制度名：Grants-in-Aid for Scientific Research

研究種目：Grant-in-Aid for Challenging Exploratory Research

2011年～ 2013年

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本研究では、がん患者の配偶者における心理的的苦痛の実態を縦断調査によりに解明し、介入研究の必要性の有無を検証した。 4つの対象者集団（①前立腺がん患者（128人）、②前立腺がん患者の妻（128人）、③非前立腺がん患者（112人）、④非前立腺がん患者の妻（112人））を4 時期（T1:前立腺生検前、T2:告知1カ月後、T3:告知3カ月後、T4:告知6カ月後）に分けて縦断的に調査した。その結果、前立腺がん患者の妻の心理的苦痛のスコアが高い状態が告知1カ月後に認められており、この時期の介入研究が最も効果的である可能性が示された。
高齢初産者の健康影響に関する前向きコホート研究:大崎国保コホート

中谷直樹

2008年～ 2008年
緑茶カテキン摂取が血中アディポネクチン値に与える影響 : ランダム化比較試験

栗山進一, 藤田和樹, 中谷直樹

2007年～ 2008年

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本研究の目的は、緑茶に含まれるカテキン摂取が血中アディポネクチン値に与える影響をランダム化比較試験により検討することである。試験参加者は20〜79歳の男女、既往歴にがん、心筋梗塞、脳血管疾患、腎疾患のない者である。平成18年6月・12月の仙台市健康増進センター減量チャレンジ講座に合わせ、講座参加者及び職員から募集を行い、51名(講座参加者31名、非参加者20名)を特定した。参加者は性(男性、女性)、減量チャレンジ講座(参加、非参加)別に無作為化され、介入群25名、対照群26名に割り付けられた。介入は介入前2週間の緑茶摂取中止を求め、その後、介入群は緑茶カテキン400mg含有飲料500mlを9週間飲用、対照群は緑茶カテキン100mg含有飲料500mlを9週間飲用した。主要効果指標として、血中アディポネクチン値を介入の前後で比較した。ベースライン時の血中アディポネクチン値は介入群より対照群で、有意ではないが高い値を示した(介入群8.23μg/ml、対照群8.79μg/ml)。9週間の介入後、血中アディポネクチン値は両群ともに有意に上昇したが(介入群1.29μg/ml上昇、対照群1.00μg/ml上昇)、群間における変化の差は有意ではなかった[0.35μg/ml(95% CI ; -1.03, 1.74)]。副次的指標において、体重、BMI、ウエスト周囲径は、介入群・対照群の両群で介入後有意に減少したが、群間における変化の差は有意ではなかった。追加解析として、血中アディポネクチン値について性別、減量チャレンジ講座別に層別化解析を実施した。血中アディポネクチン値は男性、女性ともに、群間における変化の差は有意ではなかった[男性 : 0.52μg/ml(95% Cl ; -1.71, 2.76)、女性 : 0.34μg/ml(95% Cl ; -1.55, 2.22)]。同様に、減量チャレンジ講座参加者、非参加者ともに、群間における変化の差は有意ではなかった[参加者 : 0.15 μg/ml(95% Cl ; -1.54, 1.85)、非参加者 : 1.49μg/ml(95% Cl ; -0.46, 3.43)]。以上のランダム化比較試験より、緑茶カテキン摂取による血中アディポネクチン値の有意な上昇は示されなかった。
自殺リスクに影響する要因に関する大規模前向きコホート研究

中谷直樹

2006年～ 2007年

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[目的]本研究では、日本の一般地域住民を対象とした前向きコホート研究から、自殺リスクと関連する要因を解明し、自殺予防を目指した介入方法を確立するための計画・立案を行う。本年度は、心理社会的要因、身体的要因、生活習慣、基本特性に関するデータベースを構築し、自殺リスクと関連する要因を単変量解析によって検討した。 [方法]本研究は、大崎宮城県大崎保健所管内の1市13町に居住し、平成6年8月31日時点で40〜79歳であった国民健康保険(国保)加入者全員56,294を対象としている。平成6年10月〜12月にかけて、基本特性、心理社会的要因、身体的要因、生活習慣に関する自記式アンケート調査を行い、52,029人(92.4%)から回答を得た。解析対象者は追跡開始(1995年1月)以前の死亡者及び国保からの異動者を除いた51,218名(91.0%)とした。 [結果]2001年12月末までの追跡調査を行い、110例の自殺死亡例を確認した。多変量解析の結果、独立して自殺リスクと有意に関連したのは、男性、多量飲酒者、低頻度の果物摂取、中等度以上の痛み有り者、糖尿病既往者、長睡眠時間者であった。特に、男性を対象とした検討により、(1)多量飲酒者において、自殺リスクの有意な上昇が示された。(2)飲酒量と自殺リスクとの間に直線的な量-反応関係が示された。(3)少量飲酒者において、自殺リスクが上昇する傾向(20%リスク上昇)が示された。(4)追跡開始時点から1年以内の早期死亡例を除外した時、70%9のリスク上昇が示された。今回、精神症状と密接に関連する生活習慣要因(多量飲酒、睡眠時間)、身体的要因(痛み、糖尿病既往)が自殺リスク上昇と関連した。また、うつ病が自殺リスクを高める重要な要因であることも鑑み、今後、精神面を含めた自殺予防介入方法の確立が喫緊の課題である。

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担当経験のある科目(授業) 8

地域保健・産業保健学　埼玉県立大学
医療統計学（日本語、英語）　東北大学
健康栄養情報実習　鎌倉女子大学
生物学　鎌倉女子大学
免疫学　鎌倉女子大学
医療福祉論　鎌倉女子大学
疫学　東北大学, 鎌倉女子大学
公衆衛生学　東北大学, 宮城学院女子大学, 鎌倉女子大学、埼玉県立大学

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Works（作品等） 15

中谷直樹：日本学術振興会科学研究費助成金基盤研究(C)「大規模コホート調査における配偶者のがん既往がパートナーに及ぼす健康影響（研究課題番号：17K04190）」,研究代表者,(2017-2019)
河北新報2015年1月21日朝刊リレーエッセー医進伝心／ストレス軽減策を模索 http://www.kahoku.co.jp/special/spe1140/20150121_01.html
日本学術振興会科学研究費助成金基盤研究(C) 「破局的ストレス下の慢性疾患患者における心理的・社会的側面、生活習慣及び震災影響」, 研究代表者, (2014－2016)

中谷直樹

作品分類: その他
平成26年度厚生労働省委託事業インターネットを活用した専門医の育成等事業:「心理社会学的要因とがん罹患／生存」

中谷直樹

作品分類: 芸術活動
厚生労働科学研究費補助金第3次対がん総合戦略研究事業 QOL向上のための、主に精神、心理、社会、スピリチュアルな側面からの患者・家族支援プログラムに関する研究 (研究課題番号：Ｈ２２－３次がん－一般－０３６)」分担研究者, (2012-2013)
文部科学省科学研究費補助金挑戦的萌芽研究「がん患者の配偶者における健康影響に関する縦断的研究」, 研究代表者, (2011－2013)
Homepage of the Reuters Health (August, 2010) "http://www.reuters.com/article/idUSTRE67C2O920100813"
平成22年度厚生労働省委託事業インターネットを活用した専門医の育成等事業:「心理社会学的要因とがん罹患／生存」
Homepage of the Ministry of Foreign Affairs of Denmark (April, 2008) "http://www.investindk.com/visNyhed.asp?artikelID=19507"
Homepage of the Danish Cancer Society (April, 2008) "http://www.cancer.dk/Forskning/nyheder/forskningsnyheder+2008/Japanske+forskere.htm"
日本学術振興会海外特別研究員「乳がん患者の男性パートナーにおける精神的・社会的インパクトの同定」, 研究代表者, (2008年4月－2010年3月)
文部科学省科学研究費補助金若手研究(B) 「自殺リスクに影響する要因に関する大規模前向きコホート研究」, 研究代表者, (2006－2007)
厚生労働省科学研究費補助金第3次対がん総合戦略総合事業 QOL向上のための各種患者支援プログラムの開発研究:「心理社会的要因とがん予後に関する大規模前向きコホート研究」, 研究協力者, (2006－現在に至る)
井上科学振興財団, 国際学会渡航費助成 (2004)
東北大学艮陵同窓会, 国際学会渡航費助成 (2003)

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