Details of the Researcher

PHOTO

Masatoshi Hashimoto
Section
Tohoku University Hospital
Job title
Assistant Professor
e-Rad No.
20897954

Research History 3

  • 2023/01 - Present
    Tohoku University　University Hospital Pediatric Surgery

  • 2021/01 - 2022/12
    宮城県立こども病院　外科

  • 2016/04 - 2020/12
    Tohoku University　University Hospital Pediatric Surgery

Awards 1

  1. 第12回遼太郎ちゃん基金優秀論文賞 原著部門

    2023/12　日本胆道閉鎖症研究会

Papers 1

  1. Necroptosis in biliary atresia of the liver

    Masatoshi Hashimoto, Fumiyoshi Fujishima, Thanpisit Lomphithak, Siriporn Jitkaew, Masaki Nio, Hironobu Sasano

    Medical Molecular Morphology　54　(4)　305-315　2021/06/22

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s00795-021-00289-3 　

    ISSN： 1860-1480

    eISSN： 1860-1499

Research Projects 1

  1. Etiology and pathogenesis of biliary atresia elucidated by cell death patterns

    Hideyuki Sasaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2021/04/01 - 2024/03/31

    More details Close

    We examined the association between necroptosis-related factors and clinical factors in a total of 103 cases, including 59 BA liver biopsies at the time of initial surgery, 14 liver explanted for liver transplantation after BA surgery, and 30 liver biopsies at the time of surgery for congenital biliary dilatation (CBD). The expression of TLR3, RIP1, and MLKL was significantly higher in the BA group than in the CBD group. Necroptosis was observed in intrahepatic bile duct epithelial cells in both BA and CBD but not in intrahepatic bile duct epithelial cells in the normal liver of neonates and infants. These results suggest that necroptosis is involved in the pathogenesis of BA. In a clinical study, γGTP showed a negative correlation with D-Bil in the early postoperative period and tended to increase during the period of increased bile excretion.