Details of the Researcher

PHOTO

Michiaki Abe
Section
Tohoku University Hospital
Job title
Associate Professor
Degree

Education 2

  • Tohoku University　Graduate School, Division of Medical Sciences

    - 1997/03/31

  • Tohoku University　Faculty of Medicine

    - 1994/03/31

Professional Memberships 18

  • JAPAN PRIMARY CARE ASSOCIATION

  • 日本家庭医医療学会（2006/11-2010/3）

  • 日本病院総合診療学会（2018/08-）

  • 日本病院管理学会（2013/04-）

  • 日本循環器学会(1996/04-)

  • 日本心脈管作動物質学会(2006/04-)

  • 日本高血圧学会(2000/04-)

  • 日本内科学会(1994/05-)

  • 日本心血管内分泌代謝学会(2006/12-)

  • 日本腎臓学会(1996/05-)

  • 米国生理学会(2004/09-)

  • 米国心臓学会(2004/09-)

  • 日本内分泌学会(2002/04-)

  • 日本リハビリテーション学会(2009/04-)

  • 日本透析医学会(2009/04-)

  • 日本超音波医学会(2011/10- 日超医学会診断基準委員会・腎動脈エコー標準化小委員)

  • 日本家庭医療学会(2008/04-)

  • 日本NO学会(2004/04-)

︎Show all ︎Show first 5

Research Areas 2

  • Life sciences / Nephrology /

  • Life sciences / Internal medicine - General /

Awards 5

  1. 優秀演題賞（オーラル賞）

    2017/09　日本医療・病院管理学会学術総会　気仙沼市立病院における震災前後の透析導入患者の推移について

  2. 優秀賞受賞

    2008/05/09　日本NO学会　『グルコースの前暴露がメサンギウム細胞におけるアンギオテンシンII 刺激による酸化ストレス産生を亢進させた』

  3. 第36回 日本心脈管作動物質学会研究奨励賞

    2007/02/09　日本心脈管作動物質学会

  4. 第36回 日本心脈管作動物質学会研究奨励賞

    2007

  5. The Kidney and Hypertension, Young Investigator Award.

    2006/10　Hydrogen peroxide, produced by high sodium stimulation, potentially stimulates the production of superoxide anion in mTAL

Papers 167

  1. Association of symptoms of neuropsychological long COVID with imaging and plasma biomarkers. International-journal

    Taizen Nakase, Yumi Takano, Shuko Nomura, Hae Woon Baek, Shin Takayama, Rie Ono, Michiaki Abe, Tadashi Ishii, Yasuko Tatewaki, Yasuyuki Taki

    Journal of the neurological sciences　483　125808-125808　2026/04/15

    DOI： 10.1016/j.jns.2026.125808 　

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    BACKGROUND: Some patients recovered from COVID-19 may experience cognitive and psychological symptoms, such as "brain fog" or neuropsychological long COVID, and its mechanism is unclear. OBJECTIVE: This study aimed to investigate the mechanism of brain damage in neuropsychological long COVID using imaging and blood biomarkers. METHODS: Patients who met the criteria on the "brain fog" screening questionnaire and provided informed consent were enrolled in this study (n = 33; mean age 38.5 years). All participants were examined using magnetic resonance imaging, single-photon emission computed tomography (assessment of regional cerebral blood flow [rCBF]), and blood biomarkers. Neuropsychological tests (Montreal Cognitive Assessment-Japanese version [MoCA-J], Trail Making Test [TMT], Frontal Assessment Battery, Digital Symbol Coding [DSC] test, State-Trait Anxiety Inventory [STAI], and Self-Rating Depression Scale [SDS]) were performed simultaneously. RESULTS: Significant correlations were observed between the MoCA-J score and decreased rCBF in the left occipital lobe and increased rCBF in the right occipital lobe (p < 0.05), between the STAI score and decreased rCBF in the right parietal lobe (p < 0.05), and between the SDS score and decreased rCBF in the right parietal lobe (p < 0.05). The MoCA-J and DSC scores were correlated with plasma levels of neurofilament light chain (p < 0 0.05). The TMT time correlated with plasma glial fibrillary acidic protein levels (p < 0.01). CONCLUSION: This study was a cross-sectional and could not distinguish pathological abnormalities. However, as correlations of neuropsychological long COVID with specific brain regions and plasma biomarkers have been elucidated, conducting a case-control analysis may be worthwhile.

  2. Citrate supplement facilitated muscle growth and renal maturation. International-journal

    Michiaki Abe, Kazuhiko Kawaguchi, Satomi Yamasaki, Toshiki Nakai, Masaharu Hatachi, Takanori Mizuno, Atsuko Masaura, Naonori Kumagai, Tadashi Ishii

    PloS one　21　(1)　e0339198　2026

    DOI： 10.1371/journal.pone.0339198 　

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    Citrate supplementation is well known to alleviate muscle fatigue. Furthermore, our previous clinical study revealed that citrate supplementation prevents renal oxidative stress and dysfunction. We hypothesize that an interaction between muscle and kidney tissues underlies the effects of citrate supplementation. This study investigated the effects of a citrate agent, potassium citrate/sodium citrate (PCSC), on muscle and renal functions. Male Sprague-Dawley rats were randomly assigned to two groups (control and PCSC groups). PCSC (2000 mg/kg body weight) was administered orally administrated for one week. Kidney weight, vastus lateralis muscle weight, and renal function were compared between the groups. Subsequently, the kidney and muscle tissues were analyzed using metabolomics. The PCSC group showed a significant increase in muscle mass relative to the weight gain (p = 0.0472). Renal function development with growth was more pronounced in the PCSC group (p < 0.0001). Metabolomic analysis of muscle tissue in the PCSC group revealed increased alanine levels and decreased levels of sarcosine, creatinine, and NADPH/NADP+ ratio. In the kidney tissue, PCSC supplementation led to elevated N,N-dimethylglycine, urea, and the ratio of malic acid to aspartate, while betaine aldehyde, carnitine, and Fisher's ratio decreased. The study concluded that PCSC supplement facilitated muscle growth metabolically through an alanine-associated pathway and renal function development by increasing intrarenal urea and accelerating the malate-shuttle and the betaine pathway. These findings indicate PCSC's potential impact of PCSCs on muscle-kidney interactions.

  3. Correction: Oral alkalinizing supplementation suppressed intrarenal reactive oxidative stress in mild-stage chronic kidney disease: a randomized cohort study.

    Michiaki Abe, Takuhiro Yamaguchi, Seizo Koshiba, Shin Takayama, Toshiki Nakai, Koichiro Nishioka, Satomi Yamasaki, Kazuhiko Kawaguchi, Masanori Umeyama, Atsuko Masaura, Kota Ishizawa, Ryutaro Arita, Takeshi Kanno, Tetsuya Akaishi, Mariko Miyazaki, Takaaki Abe, Tetsuhiro Tanaka, Tadashi Ishii

    Clinical and experimental nephrology　29　(8)　1116-1127　2025/08

    DOI： 10.1007/s10157-025-02733-5 　

  4. Effectiveness of Japanese traditional medicine (Kamikihito and Saikokeishito) for treating long COVID: a prospective observational study

    Rie Ono, Shin Takayama, Ryutaro Arita, Kota Ishizawa, Akiko Kikuchi, Michiaki Abe, Minoru Ohsawa, Natsumi Saito, Takeshi Kanno, Koh Onodera, Tadashi Ishii

    Frontiers in Medicine　12　2025/07/21

    Publisher: Frontiers Media SA

    DOI： 10.3389/fmed.2025.1609812 　

    eISSN： 2296-858X

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    Background Long COVID symptoms, especially brain fog, significantly impair patient quality of life (QOL); however, effective treatments remain elusive. Japanese traditional medicine (JTM, usually called Kampo medicine) is often used adjunctively to treat patients with diverse manifestations of long COVID. Objective To evaluate the effectiveness of JTM in treating long COVID using a comprehensive QOL assessment. Methods This single-center, prospective observational study evaluated QOL changes in patients with symptoms persisting beyond 28 days from the onset of COVID-19 (long COVID) who visited our general medicine outpatient department between October 2021 and August 2024. The treatment plan was determined by the attending physician based on the patient’s condition. The health-related QOL (HR-QOL) was comprehensively assessed using EuroQol-5 demensions-5levels (EQ-5D-5L) scores (ranging from −0.025 to 1.000, with higher values indicating better HR-QOL) at baseline and 3 months after the first visit. The formulations and factors associated with QOL changes were analyzed using multivariate logistic regression analyses. Results We analyzed 112 patients. The most common symptoms were fatigue (83.9%). The median (interquartile range) HR-QOL of the entire cohort significantly increased from 0.711 (0.561–0.711) at baseline to 0.833 (0.671–0.890) at 3 months (p &amp;lt; 0.0001); the proportion of patients exceeding the national standard significantly increased from 7.1% to 20.4% (p = 0.0037). The brain fog patients group (50.0%, N = 56), the median (interquartile range) HR-QOL of the entire cohort significantly increased from 0.677 (0.551–0.770) at baseline to 0.750 (0.623–0.846) at 3 months (p &amp;lt; 0.005). However, the proportion of patients achieving the Japanese average HR-QOL did not show improvement significantly. A total of 101 patients (90.2%) were treated with JTM, and a combination of kamikihito and saikokeishito was administered to 20 patients. Multivariate regression analysis revealed that the combination usage was associated with greater improvements in the HR-QOL in all patients (odds ratio 5.4) and brain fog patients’ group (odds ratio 6.1). Conclusion Long COVID treatment involving JTM improved the patients’ QOL at 3 months. The combination of kamikihito with saikokeishito may be a potential treatment option for long COVID. However, a randomized controlled trial is required to confirm its efficacy.

  5. Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

    Shun Kodate, Mitsuharu Sato, Eiji Hishinuma, Kaname Kojima, Ikuko N. Motoike, Hikaru Abe, Michiaki Abe, Momoka Abe, Naomi Abe, Noriko Abe, Tomomi Abe, Yuto Abe, Shizuko Ahiko, Kayo Aiki, Hiromi Aizawa, Yukari Akiyama, Hayato Anzawa, Eri Aoki, Yuichi Aoki, Hiroko Arai, Misaki Arakawa, Yukie Asano, Liam Baird, Ayano Chiba, Haruna Chiba, Ippei Chiba, Kenji Chiba, Tetsuo Chiba, Hisako Endo, Reika Fue, Futaba Fujishiro, Yayoi Fujita, Waka Fukunaga, Mami Funata, Takamitsu Funayama, Sho Furuhashi, Nobuo Fuse, Junko Fushimi, Kumiko Fushiya, Tomomi Gamo, Chinatsu Gocho, Katsuhiro Gonoi, Maki Goto, Takahiko Goto, Yukie Goto, Kaori Gouko, Michiko Haga, Yoko Haga, Hiroko Hamada, Yumiko Hamaie, Yohei Hamanaka, Mika Hanazawa, Yukari Hara, Atsushi Hasegawa, Asuka Hatakeyama, Sumika Hatakeyama, Nozomi Hatanaka, Rieko Hatanaka, Takanori Hidaka, Kenji Hino, Hiroe Hirama, Ikuo Hirano, Sachiko Hirano, Takumi Hirata, Masahiro Hiratsuka, Yuki Hiratsuka, Ikuko Hirayama, Takako Hoshi, Atsushi Hozawa, Keisuke Ido, Nobuko Igari, Chikako Iida, Katsuko Imai, Makiko Inoue, Reiko Inoue, Rumi Irie, Motoko Ishida, Noriko Ishida, Eri Ishigaka, Chihiro Ishii, Kaori Ishii, Osamu Ishii, Tadashi Ishii, Tatsuro Ishikawa, Mami Ishikuro, Kazutoshi Ishimori, Miho Itabashi, Kumiko Ito, Maiko Ito, Masumi Ito, Mayumi Ito, Megumi Ito, Natsuko Ito, Rie Ito, Saori Ito, Fumihiko Iwabuchi, Maki Iwabuchi, Yoko Izumi, Yoshiko Izumi, Masataka Kambe, Takanari Kanno, Mayu Kano, Naoko Kasahara, Hinako Kashiwa, Kiyomi Katahira, Mayumi Kato, Yukie Kato, Fumiki Katsuoka, Takeshi Kawabata, Rika Kawada, Aoi Kawagoe, Hiroshi Kawame, Junko Kawashima, Yukako Kawashima, Junko Kikuchi, Tsuyoshi Kikukawa, Masahiro Kikuya, Masae Kimura, Michiko Kimura, Ikuko Kishi, Tomoko Kishimoto, Tamie Kitaura, Mika Kobayashi, Tadao Kobayashi, Tomoko Kobayashi, Eiichi Kodama, Shun Kodate, Mana Kogure, Toshisada Kohagizawa, Naomi Kohketsu, Noa Koida, Chie Koide, Mika Koide, Toshihiko Koike, Junko Komatsu, Ayumi Kondo, Riyo Konno, Yukie Konno, Sachie Koreeda, Seizo Koshiba, Takuya Koyama, Hisaaki Kudo, Kazuki Kumada, Ryoko Kumadaki, Rika Kumagai, Toshie Kumagai, Yuko Kumagai, Yasuto Kunii, Miho Kuriki, Shinichi Kuriyama, Emiko Kurokawa, Seiko Kurota, Hisako Kusano, Bin Li, Donghan Li, Xue Li, Kanako Maeshibu, Keiko Maeta, Satoshi Makino, Hiroko Matsubara, Naomi Matsukawa, Masako Matsumoto, Takako Matsuoka, Yuka Matsushita, Motomichi Matsuzaki, Hirohito Metoki, Sayaka Minakawa, Yuki Minami, Kyoko Mitate, Satomi Mito, Ayako Miura, Noriko Miura, Ryo Miyagi, Akiko Miyazawa, Satoshi Mizuno, Akiko Mochida, Mika Momii, Hiroko Mori, Naoko Mori, Hozumi Motohashi, Ikuko Motoike, Shunji Mugikura, Keiko Murakami, Takahisa Murakami, Masato Nagai, Satoshi Nagaie, Fuji Nagami, Toko Naganuma, Tatsuo Nagasaka, Sachiko Nagase, Kumiko Nakagawa, Taku Nakai, Noriko Nakajo, Kyoko Nakamichi, Chie Nakamura, Naoki Nakamura, Tomohiro Nakamura, Yuko Nakasato, Kumi Nakaya, Naoki Nakaya, Kei Nanatani, Akira Narita, Yuka Narita, Yasuhisa Nemoto, Hafumi Nishi, Kohji Nishida, Ichiko Nishijima, Momo Nishiyama, Takahiro Nobukuni, Kotaro Nochioka, Aoi Noda, Kenichi Noguchi, Kiriko Nozoe, Rie Nunokawa, Taku Obara, Tomoko Obara, Kaori Ogasawara, Satoru Ogawa, Soichi Ogishima, Natsuki Oguma, Nahoko Ohi, Namiko Ohisa, Kinuko Ohneda, Hayami Ohori, Miri Oikawa, Yumi Oikawa, Yumiko Ojima, Yumi Okada, Yasunobu Okamura, Hiroshi Okuda, Mitsuko Okuda, Ayako Okumoto, Akane Ono, Chiaki Ono, Genki Onodera, Kaname Onodera, Masako Onodera, Midori Onuma, Tomomi Onuma, Keiichiro Oohashi, Masumi Oomachi, Kazuya Ootomo, Yukie Oouchi, Masatsugu Orui, Mayumi Osada, Tamae Osanai, Reiko Ota, Noriko Otake, Sumie Otomo, Akihito Otsuki, Yoko Otsuki, Yuki Oyama, Keiko Oyamada, Yoko Ozawa, Satomi Obara, Daisuke Saigusa, Asami Saito, Hisako Saito, Kazue Saito, Manami Saito, Megumi Saito, Ritsumi Saito, Sakae Saito, Tomo Saito, Yoko Saito, Yuki Saito, Yoshinobu Saitoh, Hiroko Sakai, Masaki Sakaida, Hiroshi Sakamono, Hiromi Sakamoto, Kana Sakamoto, Mia Sakamoto, Kasumi Sakurai, Miyuki Sakurai, Rieko Sakurai, Mika Yageta, Kana Sasaki, Miho Sasaki, Tadashi Sasaki, Yukari Sasaki, Yukie Sasaki, Chika Sato, Hirokazu Sato, Michiyo Sato, Miho Sato, Miu Sato, Naoko Sato, Reiko Sato, Satoshi Sato, Shiho Sato, Taku Sato, Yoshiko Sato, Youko Sato, Yui Sato, Michihiro Satoh, Ayako Sekiya, Mariko Seo, Yoshiko Shima, Muneaki Shimada, Atsushi Shimizu, Ritsuko Shimizu, Genki Shinoda, Nobuyuki Shirakawa, Matsuyuki Shirota, Hiroe Shoji, Ikuko Shoji, Mariko Shoji, Midori Shoji, Wakako Shoji, Satomi Someya, Shinya Sonobe, Itsumi Sou, Rie Suenaga, Yasuko Suenaga, Mayumi Suga, Rika Sugai, Junichi Sugawara, Megumi Sugawara, Michiko Sugawara, Nanako Sugawara, Saori Sugawara, Yuki Sugawara, Sachiyo Sugimoto, Airi Suzuki, Ayano Suzuki, Keiko Suzuki, Michirou Suzuki, Mikiko Suzuki, Norio Suzuki, Rie Suzuki, Ryoko Suzuki, Takafumi Suzuki, Tatsuya Suzuki, Yoichi Suzuki, Shu Tadaka, Keiko Taguchi, Nozomi Taiji, Makiko Taira, Kaori Takagi, Emi Takahashi, Harumi Takahashi, Junko Takahashi, Megumi Takahashi, Noriko Takahashi, Rieko Takahashi, Yukiko Takahashi, Mayuko Takasawa, Masato Takase, Jun Takayama, Miho Takeuchi, Sayaka Takita, Toru Tamahara, Gen Tamiya, Naomi Tamura, Akari Tanaka, Saiko Tanaka, Chihiro Tanno, Naoko Tanno, Keiko Tateno, Minoru Tateno, Chika Terui, Mihoko Toki, Sayuri Tokioka, Etsuko Tomita, Hiroaki Tomita, Mai Tomizuka, Naho Tsuchiya, Miyuki Tsuda, Tomomi Tsumuraya, Junko Tsunasawa, Issei Tsunoda, Juri Uchiya, Akiko Ueda, Yuriko Ueki, Fumihiko Ueno, Keiko Umeda, Akira Uruno, Ikuko Wada, Tomoko Wada, Mika Wagatsuma, Hitoshi Watanabe, Kanako Watanabe, Kazue Watanabe, Nobuo Yaegashi, Mika Yagyu, Etsuko Yamada, Yumi Kabata, Hiroko Yamamoto, Masayuki Yamamoto, Yukari Yamauchi, Mika Yamazaki, Jun Yasuda, Hang Yin, Hiroshi Yokota, Manami Yokoyama, Marie Yokoyama, Tomoko Yokoyama, Yuko Yoshida, Mizue Yoshino, Zhiqian Yu, Lin Zhang, Seizo Koshiba, Masayuki Yamamoto, Kazunori D. Yamada, Kengo Kinoshita

    Scientific Reports　15　(1)　2025/05/16

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-025-01634-7 　

    eISSN： 2045-2322

  6. Establishment of a Collaborative System for Long COVID Brain Fog Using a Questionnaire and Scoring

    Rie Ono, Shin Takayama, Taizen Nakase, Akiko Kikuchi, Ryutaro Arita, Michiaki Abe, Takeshi Kannno, Ko Onodera, Minoru Osawa, Kota Ishizawa, Natsumi Saito, Tadashi Ishii

    An Official Journal of the Japan Primary Care Association　47　(3)　120-123　2024/09/20

    Publisher: The Japan Primary Care Association

    DOI： 10.14442/generalist.47.120 　

    ISSN： 2185-2928

    eISSN： 2187-2791

  7. 東北大学病院総合診療科で経験した視神経脊髄炎スペクトラム障害(NMOSD)の3例

    阿部 倫明, 齊藤 奈津美, 有田 龍太郎, 菅原 章人, 上條 広光, 石沢 興太, 大澤 稔, 高山 真, 小野寺 浩, 石井 正

    日本病院総合診療医学会雑誌　20　(臨増2)　275-275　2024/09

    Publisher: (一社)日本病院総合診療医学会

    ISSN： 2185-8136

    eISSN： 2758-7878

  8. Sequential Sampling of the Gastrointestinal Tract to Characterize the Entire Digestive Microbiome in Japanese Subjects

    Kota Ishizawa, Toru Tamahara, Suguo Suzuki, Yutaka Hatayama, Bin Li, Michiaki Abe, Yuichi Aoki, Ryutaro Arita, Natsumi Saito, Minoru Ohsawa, Soichiro Kaneko, Rie Ono, Shin Takayama, Muneaki Shimada, Kazuki Kumada, Tomoyuki Koike, Atsushi Masamune, Ko Onodera, Tadashi Ishii, Ritsuko Shimizu, Takeshi Kanno

    Microorganisms　12　(7)　1324-1324　2024/06/28

    Publisher: MDPI AG

    DOI： 10.3390/microorganisms12071324 　

    eISSN： 2076-2607

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    The gastrointestinal (GI) tract harbors trillions of microorganisms known to influence human health and disease, and next-generation sequencing (NGS) now enables the in-depth analysis of their diversity and functions. Although a significant amount of research has been conducted on the GI microbiome, comprehensive metagenomic datasets covering the entire tract are scarce due to cost and technical challenges. Despite the widespread use of fecal samples, integrated datasets encompassing the entire digestive process, beginning at the mouth and ending with feces, are lacking. With this study, we aimed to fill this gap by analyzing the complete metagenome of the GI tract, providing insights into the dynamics of the microbiota and potential therapeutic avenues. In this study, we delved into the complex world of the GI microbiota, which we examined in five healthy Japanese subjects. While samples from the whole GI flora and fecal samples provided sufficient bacteria, samples obtained from the stomach and duodenum posed a challenge. Using a principal coordinate analysis (PCoA), clear clustering patterns were identified; these revealed significant diversity in the duodenum. Although this study was limited by its small sample size, the flora in the overall GI tract showed unwavering consistency, while the duodenum exhibited unprecedented phylogenetic diversity. A visual heat map illustrates the discrepancy in abundance, with Fusobacteria and Bacilli dominating the upper GI tract and Clostridia and Bacteroidia dominating the fecal samples. Negativicutes and Actinobacteria were found throughout the digestive tract. This study demonstrates that it is possible to continuously collect microbiome samples throughout the human digestive tract. These findings not only shed light on the complexity of GI microbiota but also provide a basis for future research.

  9. A Case Series of Post-COVID Conditions with Fatigability Treated with Saikokeishito

    Rie Ono, Shin Takayama, Natsumi Saito, Ryutaro Arita, Akiko Kikuchi, Kota Ishizawa, Takeshi Kanno, Akito Sugawara, Minoru Ohsawa, Michiaki Abe, Ko Onodeara, Tetsuya Akaishi, Tadashi Ishii

    An Official Journal of the Japan Primary Care Association　47　(2)　49-55　2024/06/20

    Publisher: The Japan Primary Care Association

    DOI： 10.14442/generalist.47.49 　

    ISSN： 2185-2928

    eISSN： 2187-2791

  10. Oral alkalinizing supplementation suppressed intrarenal reactive oxidative stress in mild-stage chronic kidney disease: a randomized cohort study.

    Michiaki Abe, Takuhiro Yamaguchi, Seizo Koshiba, Shin Takayama, Toshiki Nakai, Koichiro Nishioka, Satomi Yamasaki, Kazuhiko Kawaguchi, Masanori Umeyama, Atsuko Masaura, Kota Ishizawa, Ryutaro Arita, Takeshi Kanno, Tetsuya Akaishi, Mariko Miyazaki, Takaaki Abe, Tetsuhiro Tanaka, Tadashi Ishii

    Clinical and experimental nephrology　2024/06/13

    DOI： 10.1007/s10157-024-02517-3 　

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    BACKGROUND: The beneficial effects of oral supplements with alkalinizing agents in patients with chronic kidney disease (CKD) have been limited to the severe stages. We investigated whether two types of supplements, sodium bicarbonate (SB) and potassium citrate/sodium citrate (PCSC), could maintain renal function in patients with mild-stage CKD. METHODS: This was a single-center, open-labeled, randomized cohort trial. Study participants with CKD stages G2, G3a, and G3b were enrolled between March 2013 and January 2019 and randomly assigned by stratification according to age, sex, estimated glomerular filtration rate (eGFR), and diabetes. They were followed up for 6 months (short-term study) for the primary endpoints and extended to 2 years (long-term study) for the secondary endpoints. Supplementary doses were adjusted to achieve an early morning urinary pH of 6.8-7.2. We observed renal dysfunction or new-onset cerebrovascular disease and evaluated urinary surrogate markers for renal injury. RESULTS: Overall, 101 participants were registered and allocated to three groups: standard (n = 32), SB (n = 34), and PCSC (n = 35). Two patients in the standard group attained the primary endpoints (renal stones and overt proteinuria) but were not statistically significant. There was one patient in the standard reduced eGFR during the long-term study (p = 0.042 by ANOVA). SB increased proteinuria (p = 0.0139, baseline vs. 6 months), whereas PCSC significantly reduced proteinuria (p = 0.0061, baseline vs. 1 year, or p = 0.0186, vs. 2 years) and urinary excretion of 8-hydroxy-2'-deoxyguanosine (p = 0.0481, baseline vs. 6 months). CONCLUSION: This study is the first to report supplementation of PCSC reduced intrarenal oxidative stress in patients with mild-stage CKD.

  11. Growth Differentiation Factor-15 Is Considered a Predictive Biomarker of Long COVID in Non-hospitalized Patients. International-journal

    Rie Ono, Shin Takayama, Michiaki Abe, Ryutaro Arita, Takaaki Abe, Tadashi Ishii

    Cureus　16　(5)　e59433　2024/05

    DOI： 10.7759/cureus.59433 　

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    Mitochondrial dysfunction is associated with various diseases. Mitochondria plays a regulatory role during infection. The association between mitokines and subsequent COVID progression has not been previously studied. The retrospective cohort study aimed to investigate the potential of serum mitokines as long COVID biomarkers in non-hospitalized patients. Patients with confirmed SARS-CoV-2 infection and blood test reports between January 2021 and April 2023 were included. Patients were categorized into two groups, the recovered and long COVID groups, based on fatigue, decline in focus, and pain. Serum levels of growth differentiation factor 15 (GDF-15) and fibroblast growth factor-21 (FGF-21), which are affected by mitochondrial function, along with inflammatory and vascular endothelium markers, were measured using enzyme-linked immunosorbent assays (ELISA). A receiver operating characteristic curve was used to screen the biomarkers. The threshold value of GDF-15 in the acute phase was 965 pg/mL (sensitivity: 71.4%, specificity: 83.3%), indicating that GDF-15 may be associated with the presence of symptoms three months post onset. No association with inflammatory markers and vascular structures was observed. Therefore, elevated GDF-15 levels in the acute phase may act as a predictive biomarker of long COVID.

  12. Subjective Physical Symptoms Related to Bad Weather Among Persons Undergoing Medical Check-Up: A Single-Center Observational Study. International-journal

    Tetsuya Akaishi, Toshiaki Saito, Michiaki Abe, Tadashi Ishii

    Cureus　15　(12)　e50642　2023/12

    DOI： 10.7759/cureus.50642 　

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    Background and aim The prevalence and characteristics of physical complaints related to bad weather among the general population remain poorly understood. This study aimed to elucidate the characteristics of subjective physical symptoms related to bad weather. Methods A cross-sectional survey was conducted by using self-reported health-related questionnaires obtained from individuals undergoing annual medical check-ups at a municipal hospital in Japan. Participants were asked about the presence and details of physical symptoms related to bad weather, together with other health-related questions. Results Among the 133 participants, 42 (32%) (95%CI 24-40) reported experiencing physical conditions related to bad weather. Among these 42 patients, the most common ailment was headache (67%; n=28), followed by low back pain (21%; n=9), fatigue (19%; n=8), and stiff neck/shoulder discomfort (12%; n=5). Comparison between individuals with and without bad weather-related conditions revealed that those affected were younger (p=0.0014) and exhibited higher numerical rating scale scores for gastrointestinal problems (p=0.0027), irritability/agitation (p<0.0001), and sleep disorders (p=0.0295). These associations were confirmed even after adjusting for age and sex. Conclusions Physical conditions related to bad weather, represented by headache, fatigue, and back pain, can be seen in 25-40% of the general population, especially in younger age groups. Individuals with these conditions are more likely to experience irritability/agitation, gastrointestinal problems, and sleep disorders.

  13. Progress and treatment of “long <scp>COVID</scp> ” in non‐hospitalized patients: A single‐center retrospective cohort study

    Rie Ono, Ryutaro Arita, Shin Takayama, Takeshi Kanno, Akiko Kikuchi, Satoko Suzuki, Minoru Ohsawa, Natsumi Saito, Michiaki Abe, Koh Onodera, Tetsuya Akaishi, Yasunori Tadano, Tadashi Ishii

    Traditional &amp; Kampo Medicine　10　(2)　150-158　2023/05/25

    Publisher: Wiley

    DOI： 10.1002/tkm2.1370 　

    ISSN： 2053-4515

    eISSN： 2053-4515

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    Abstract Background “Long COVID” or “post‐COVID conditions” describes prolonged symptoms after the acute phase of coronavirus disease 2019 (COVID‐19). However, there is a paucity of published reports on its treatment. Method This retrospective cohort study included adult, non‐hospitalized patients with COVID‐19 symptoms at least one month after the onset who had been examined at the isolation facility in Miyagi prefecture between October 2020 and September 2021. Results In total, 70 patients with a median age of 46 (21–69) years were included, and 37 were women (52.9%). The median time from onset to the end of treatment was 46 (28–396) days. Thirty‐eight patients (53.5%) showed improvement in all symptoms, while four (5.7%) did not recover within the study period. The symptoms at six months with high residual rates were dizziness (33.3%), fatigue (14.3%), myalgia (14.3%), abdominal discomfort (14.3%), and taste dysfunction (11.8%). For treatment of prolonged symptoms, formulae of Kampo medicine (Japanese traditional medicine) were used alone or in combination with Western medications in 76%, 66%, 53%, and 66% of patients at 1–2 months, 2–3 months, 3–6 months, and over 6 months respectively. Kampo formulae with anti‐inflammatory effects were used in the early period; however, tonifying formulae and blood stasis‐resolving formulae were used in the late period. Conclusion Non‐hospitalized patients with COVID‐19 may suffer from persistent symptoms after the acute phase of infection. For the management of long COVID, a comprehensive and holistic approach is needed. Kampo medicine should be considered as a treatment option for long COVID.

  14. COVID-19軽症者等療養施設におけるモルヌピラビルの効果と安全性

    有田 龍太郎, 高山 真, 阿部 倫明, 菊地 章子, 大澤 稔, 小野寺 浩, 菅野 武, 齊藤 奈津美, 赤石 哲也, 小野 理恵, 只野 恭教, 鈴木 聡子, 菅原 章人, 石井 正

    日本プライマリ・ケア連合学会学術大会　14回　219-219　2023/05

    Publisher: (一社)日本プライマリ・ケア連合学会

  15. COVID-19軽症者等療養施設におけるモルヌピラビルの効果と安全性

    有田 龍太郎, 高山 真, 阿部 倫明, 菊地 章子, 大澤 稔, 小野寺 浩, 菅野 武, 齊藤 奈津美, 赤石 哲也, 小野 理恵, 只野 恭教, 鈴木 聡子, 菅原 章人, 石井 正

    日本プライマリ・ケア連合学会学術大会　14回　219-219　2023/05

    Publisher: (一社)日本プライマリ・ケア連合学会

  16. Predictors for the Development of Hypoxia or Prolonged Acute Symptoms Among Non-Hospitalized Mild-To-Moderate Patients with Coronavirus Disease 2019

    Yasunori Tadano, Tetsuya Akaishi, Satoko Suzuki, Rie Ono, Natsumi Saito, Ryutaro Arita, Takeshi Kanno, Junichi Tanaka, Akiko Kikuchi, Minoru Ohsawa, Shin Takayama, Michiaki Abe, Ko Onodera, Tadashi Ishii

    The Tohoku Journal of Experimental Medicine　260　(3)　231-244　2023

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.2023.j038 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  17. 新型コロナウイルス感染症軽症者等宿泊療養施設における管理課題解決のための情報共有・往診システムの構築

    高山 真, 有田 龍太郎, 小野 理恵, 只野 恭教, 菊地 章子, 稲葉 洋平, 中村 直毅, 阿部 倫明, 石井 正

    日本医療・病院管理学会誌　59　(4)　157-167　2022/10

    Publisher: (一社)日本医療・病院管理学会

    ISSN： 1882-594X

    eISSN： 2185-422X

  18. COVID-19-Related Symptoms during the SARS-CoV-2 Omicron (B.1.1.529) Variant Surge in Japan.

    Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Noriko Sugawara, Hiroshi Egusa, Kaoru Igarashi, Motoo Fujita, Shigeo Kure, Shin Takayama, Michiaki Abe, Akiko Kikuchi, Minoru Ohsawa, Kota Ishizawa, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tadashi Ishii

    The Tohoku journal of experimental medicine　258　(2)　103-110　2022/08/25

    DOI： 10.1620/tjem.2022.J067 　

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    The exact profiles of the clinical symptoms related to the SARS-CoV-2 Omicron variant (B.1.1.529) remain largely uncertain. Therefore, this study aimed to clarify the clinical manifestations of infection with this variant. We enrolled individuals who were tested by quantitative nasopharyngeal swab reverse transcription-polymerase chain reaction (RT-PCR) test at a large screening center in a city of Japan during the B.1.1.529 Omicron variant wave between January and May 2022, after contact with COVID-19 patients. Swab tests were planned to be performed approximately 4-5 days after contact. The presence of COVID-19-related symptoms was assessed at the swab test site. Among the 2,507 enrolled individuals, 943 (37.6%) were RT-PCR test-positive and 1,564 (62.4%) were test-negative. Among the 943 PCR test-positive participants, the prevalence of the symptoms was as follows: 47.3% with cough, 32.9% with sore throat, 18.4% with fatigability, 12.7% with fever of ≥ 37.5℃, 9.9% with dyspnea, 2.1% with dysosmia, and 1.4% with dysgeusia. The prevalence of cough, sore throat, dyspnea, and fatigability was higher among adults aged ≥ 18 years than among children and adolescents. The prevalence of dysosmia and dysgeusia remarkably decreased during the Omicron wave (1-3%) compared to during the pre-Omicron variant waves (15-25%). In summary, common COVID-19-related symptoms during the Omicron variant wave included cough and sore throat, followed by fatigability, fever, and dyspnea. The prevalence of most of these symptoms was higher in adults than in non-adults. The prevalence of dysosmia and dysgeusia remarkably decreased with the Omicron variant than with pre-Omicron variants.

  19. Effectiveness of third vaccine dose for coronavirus disease 2019 during the Omicron variant pandemic: a prospective observational study in Japan

    Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Noriko Sugawara, Hiroshi Egusa, Kaoru Igarashi, Motoo Fujita, Shigeo Kure, Shin Takayama, Michiaki Abe, Akiko Kikuchi, Minoru Ohsawa, Kota Ishizawa, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tadashi Ishii

    Scientific Reports　12　(1)　2022/08/10

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-022-17990-7 　

    eISSN： 2045-2322

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    Abstract The administration of a third booster dose of messenger ribonucleic acid (mRNA) vaccines against coronavirus disease 2019 (COVID-19) has progressed worldwide. Since January 2022, Japan has faced a nationwide outbreak caused by the Omicron variant, which occurred simultaneously with the progression of mass vaccination with the third booster dose. Therefore, this study evaluated the effectiveness of the third dose of vaccine by reverse transcription-polymerase chain reaction (RT-PCR) test using nasopharyngeal swab samples from adults aged ≥ 18 years tested after having close contact with COVID-19 cases between January and May 2022. Participants who completed only one dose were excluded from the study. Among the 928 enrolled participants, 139 had never been vaccinated, 609 had completed two doses, 180 had completed three doses before the swab test, and the overall RT-PCR test positivity rate in each group was 48.9%, 46.0%, and 32.2%, respectively. The vaccine effectiveness of the third dose to prevent infection after close contact was approximately 40% (95% confidence interval: 20–60%), which was the highest at 10–70 days after receiving the third dose. In conclusion, the effectiveness of the three-dose mRNA COVID-19 vaccine after close contact during the Omicron outbreak is approximately 40%.

  20. Refractory Chest Pain in Mild to Moderate Coronavirus Disease 2019 Successfully Treated with Saikanto, a Japanese Traditional Medicine.

    Ryutaro Arita, Rie Ono, Natsumi Saito, Satoko Suzuki, Akiko Kikuchi, Minoru Ohsawa, Yasunori Tadano, Tetsuya Akaishi, Takeshi Kanno, Michiaki Abe, Ko Onodera, Shin Takayama, Tadashi Ishii

    The Tohoku journal of experimental medicine　257　(3)　241-249　2022/05/20

    DOI： 10.1620/tjem.2022.J040 　

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    Coronavirus disease 2019 (COVID-19) causes a variety of pain symptoms in the acute phase. Severe chest pain suddenly occurs even without abnormalities on examination and is sometimes refractory to analgesics. Such pain is a clinical concern in care facilities with limited resources, and this is the first report on the use of saikanto for its treatment. In Miyagi Prefecture, Japan, COVID-19 patients with mild symptoms were admitted to a hotel that operated as an isolation facility, and their symptoms were observed. In this article, we report four cases in which chest pain comorbid with mild to moderate COVID-19 was successfully treated with saikanto, a traditional Japanese (Kampo) medicine. The patients presented with chest pain and underwent medical examination at the facility. Two patients had severe chest pain refractory to acetaminophen. Critical cardiopulmonary diseases were ruled out in all the patients, and three patients had features of pneumonia on chest radiograph. Medications, including saikanto, were administered to the patients. The patients' chest pain and other symptoms improved 1-4 days after the administration of saikanto, and they left the care facility without hospitalization. The cause of the chest pain experienced by these patients is unclear, but we speculate that it could be minimal pleural inflammation or neuropathy. Previous pharmacological studies have suggested anti-inflammatory and analgesic properties of the crude drugs that constitute saikanto. This case report suggests that saikanto could be a treatment option for chest pain refractory to analgesics in patients with mild to moderate COVID-19.

  21. Effectiveness of mRNA COVID-19 Vaccines in Japan during the Nationwide Pandemic of the Delta Variant.

    Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Noriko Sugawara, Kaoru Igarashi, Motoo Fujita, Shigeo Kure, Shin Takayama, Michiaki Abe, Akiko Kikuchi, Kota Ishizawa, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tadashi Ishii

    The Tohoku journal of experimental medicine　257　(1)　1-6　2022/05/13

    DOI： 10.1620/tjem.2022.J012 　

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    The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remained a major global health concern in 2021. To suppress the spread of infection, mass vaccinations have been performed across countries worldwide. In Japan, vaccinations of the first and second doses for most of the nation were performed during the nationwide outbreak of the B.1.617.2 (Delta) variant with the L452R spike protein mutation, and the effectiveness of the vaccinations to suppress the spread of COVID-19 among the people in Japan remains uncertain. In this study, adults aged ≥18 years, who were in contact with patients with COVID-19 and underwent nasopharyngeal swab reverse transcription-polymerase chain reaction (RT-PCR) tests during August and September 2021 at a mass screening test center in Japan, were enrolled. In this period, more than 95% of the COVID-19 infections were reportedly caused by the Delta variant. As a result, a total of 784 adults with recent contact history, including 231 (29.5%) RT-PCR test-positive cases, were enrolled. The test positivity rate was lower in individuals who had been vaccinated twice than in unvaccinated individuals (12.5% vs. 39.0%, p < 0.0001), with the risk ratio of 0.32 (95% confidence interval 0.23-0.46). The vaccine effectiveness was the highest between 7-90 days after the second vaccine dose. In conclusion, two doses of mRNA COVID-19 vaccines effectively suppressed transmission in Japan during the nationwide pandemic of the Delta variant, estimated to have prevented 50-80% of the infection.

  22. A massive natural disaster, the Great East Japan Earthquake, and the incidence of dialysis due to end-stage kidney disease. International-journal

    Michiaki Abe, Tetsuya Akaishi, Koto Ishizawa, Hirohisa Shinano, Hiroshi Ohtomo, Kazuhiko Orikasa, Shin Takayama, Atsuko Masaura, Mariko Miyazaki, Takaaki Abe, Kenichi Yokota, Tadashi Ishii

    Journal of nephrology　35　(3)　719-724　2022/04

    DOI： 10.1007/s40620-021-01140-9 　

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    BACKGROUND: Disaster-related stress can increase blood pressure and the incidence of cardiovascular diseases. However, the role of massive disasters in the development of end-stage kidney disease (ESKD) remains unknown. We investigated the incidence and different causes of dialysis initiation in patients with chronic kidney disease in a city affected by the Great East Japan Earthquake. METHODS: This was a single-center, retrospective observational study. All patients who initiated or were treated with dialysis at Kesennuma City Hospital between 2007 and 2020 were enrolled. The year of dialysis initiation was retrospectively determined based on the initiation date. The causative renal diseases that led to the need for dialysis initiation were divided into four groups: diabetic nephropathy, hypertensive renal disease, glomerulonephritis, and others. RESULTS: Age at dialysis initiation differed significantly among the four groups (p = 0.0262). There was a significant difference in the numbers of the four groups before and after the Great East Japan Earthquake (p = 0.0193). The age of hypertensive renal disease patients was significantly higher than those of patients with diabetic nephropathy (p = 0.0070) and glomerulonephritis (p = 0.0386) after the disaster. The increasing number of dialysis initiations after the Great East Japan Earthquake appeared to be associated with changes in hypertensive renal diseases; the number peaked after 10 years. CONCLUSIONS: There was an increase in the number of dialysis initiations, especially caused by hypertensive renal diseases, for up to 10 years after the Great East Japan Earthquake.

  23. COVID-19宿泊療養施設におけるステロイド剤使用経験の報告

    菊地 章子, 小野 理恵, 有田 龍太郎, 只野 恭教, 齊藤 奈津美, 大澤 稔, 阿部 倫明, 高山 真, 小野寺 浩, 石井 正

    日本内科学会雑誌　111　(Suppl.)　214-214　2022/02

    Publisher: (一社)日本内科学会

    ISSN： 0021-5384

    eISSN： 1883-2083

  24. COVID-19宿泊療養施設におけるステロイド剤使用経験の報告

    菊地 章子, 小野 理恵, 有田 龍太郎, 只野 恭教, 齊藤 奈津美, 大澤 稔, 阿部 倫明, 高山 真, 小野寺 浩, 石井 正

    日本内科学会雑誌　111　(Suppl.)　214-214　2022/02

    Publisher: (一社)日本内科学会

    ISSN： 0021-5384

    eISSN： 1883-2083

  25. Response to Glucocorticoid Therapy in Patients with Mild to Moderate Coronavirus Disease 2019 at a Japanese Care Facility

    Akiko Kikuchi, Ryutaro Arita, Rie Ono, Yasunori Tadano, Natsumi Saito, Tetsuya Akaishi, Takeshi Kanno, Minoru Osawa, Shin Takayama, Michiaki Abe, Ko Onodera, Tadashi Ishii

    The Tohoku Journal of Experimental Medicine　257　(2)　97-106　2022

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.2022.j022 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  26. dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project Invited Peer-reviewed

    Soichi Ogishima, Satoshi Nagaie, Satoshi Mizuno, Ryosuke Ishiwata, Keita Iida, Kazuro Shimokawa, Takako Takai-Igarashi, Naoki Nakamura, Sachiko Nagase, Tomohiro Nakamura, Naho Tsuchiya, Naoki Nakaya, Keiko Murakami, Fumihiko Ueno, Tomomi Onuma, Mami Ishikuro, Taku Obara, Shunji Mugikura, Hiroaki Tomita, Akira Uruno, Tomoko Kobayashi, Akito Tsuboi, Shu Tadaka, Fumiki Katsuoka, Akira Narita, Mika Sakurai, Satoshi Makino, Gen Tamiya, Yuichi Aoki, Ritsuko Shimizu, Ikuko N. Motoike, Seizo Koshiba, Naoko Minegishi, Kazuki Kumada, Takahiro Nobukuni, Kichiya Suzuki, Inaho Danjoh, Fuji Nagami, Kozo Tanno, Hideki Ohmomo, Koichi Asahi, Atsushi Shimizu, Atsushi Hozawa, Shinichi Kuriyama, Masayuki Yamamoto, Michiaki Abe, Yayoi Aizawa, Yuichi Aoki, Koichi Chida, Inaho Danjoh, Shinichi Egawa, Ai Eto, Takamitsu Funayama, Nobuo Fuse, Yohei Hamanaka, Yuki Harada, Hiroaki Hashizume, Shinichi Higuchi, Sachiko Hirano, Takumi Hirata, Masahiro Hiratsuka, Atsushi Hozawa, Kazuhiko Igarashi, Jin Inoue, Noriko Ishida, Naoto Ishii, Tadashi Ishii, Mami Ishikuro, Kiyoshi Ito, Sadayoshi Ito, Maiko Kageyama, Fumiki Katsuoka, Hiroshi Kawame, Junko Kawashima, Masahiro Kikuya, Kengo Kinoshita, Kazuyuki Kitatani, Tomomi Kiyama, Hideyasu Kiyomoto, Tomoko Kobayashi, Eiichi Kodama, Mana Kogure, Kaname Kojima, Sachie Koreeda, Seizo Koshiba, Shihoko Koyama, Hisaaki Kudo, Kazuki Kumada, Shigeo Kure, Miho Kuriki, Shinichi Kuriyama, Yoko Kuroki, Norihide Maikusa, Satoshi Makino, Hiroko Matsubara, Hiroyuki Matsui, Hirohito Metoki, Takahiro Mimori, Naoko Minegishi, Kazuharu Misawa

    Human Genome Variation　8　(1)　44　2021/12

    DOI： 10.1038/s41439-021-00175-5 　

    ISSN： 2054-345X

    eISSN： 2054-345X

  27. Kampo medicine can improve quality of life and prolong hemodialysis implementation in patients with advanced‐stage chronic kidney disease

    Masayuki Shimizu, Shin Takayama, Kota Ishizawa, Michiaki Abe, Tadashi Ishii

    Traditional &amp; Kampo Medicine　8　(3)　229-233　2021/12

    Publisher: Wiley

    DOI： 10.1002/tkm2.1291 　

    ISSN： 2053-4515

    eISSN： 2053-4515

  28. 新型コロナウイルス感染症軽症者宿泊療養施設における管理課題解決のための情報共有・往診システムの構築

    高山 真, 有田 龍太郎, 小野 理恵, 菊地 章子, 阿部 倫明, 石井 正

    日本医療・病院管理学会誌　58　(Suppl.)　183-183　2021/10

    Publisher: (一社)日本医療・病院管理学会

    ISSN： 1882-594X

    eISSN： 2185-422X

  29. 脱毛治療でグリチルリチン酸内服後、偽性アルドステロン症から横紋筋融解症をきたした1例

    小野寺 浩, 阿部 倫明, 高山 真, 高橋 雄大, 松本 宏, 石井 正

    日本病院総合診療医学会雑誌　17　(4)　434-436　2021/07

    Publisher: (一社)日本病院総合診療医学会

    ISSN： 2185-8136

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    63歳女性。脱毛治療としてグリチルリチン酸配合錠を2ヵ月内服したところ、両側大腿と肩の筋肉痛が出現し、近医より当院へ紹介となった。臨床経過および検査所見から、本症例は低カルシウム血症により横紋筋融解症をきたしてると判断した。原因としてグリチルリチン酸内服による偽性アルドステロン症が考えられたことから、入院後、補液およびアスパラギン酸カリウムの内服に加え、経静脈的にカリウム補給を行った。その結果、入院10日目にはカリウム値とCK値は正常化、症状の改善が得られ、退院となった。

  30. 脱毛治療でグリチルリチン酸内服後、偽性アルドステロン症から横紋筋融解症をきたした1例

    小野寺 浩, 阿部 倫明, 高山 真, 高橋 雄大, 松本 宏, 石井 正

    日本病院総合診療医学会雑誌　17　(4)　434-436　2021/07

    Publisher: (一社)日本病院総合診療医学会

    ISSN： 2185-8136

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    63歳女性。脱毛治療としてグリチルリチン酸配合錠を2ヵ月内服したところ、両側大腿と肩の筋肉痛が出現し、近医より当院へ紹介となった。臨床経過および検査所見から、本症例は低カルシウム血症により横紋筋融解症をきたしてると判断した。原因としてグリチルリチン酸内服による偽性アルドステロン症が考えられたことから、入院後、補液およびアスパラギン酸カリウムの内服に加え、経静脈的にカリウム補給を行った。その結果、入院10日目にはカリウム値とCK値は正常化、症状の改善が得られ、退院となった。

  31. COVID-19 transmission in group living environments and households. International-journal

    Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Shigeo Kure, Kaoru Igarashi, Shin Takayama, Michiaki Abe, Junichi Tanaka, Akiko Kikuchi, Ko Onodera, Tadashi Ishii

    Scientific reports　11　(1)　11616-11616　2021/06/02

    DOI： 10.1038/s41598-021-91220-4 　

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    The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently the world's largest public health concern. This study evaluated COVID-19 transmission risks in people in group living environments. A total of 4550 individuals with a history of recent contact with patients at different places (dormitory/home/outside the residences) and levels (close/lower-risk) were tested for SARS-CoV-2 viral RNA using a nasopharyngeal swab test between July 2020 and May 2021. The test-positive rate was highest in individuals who had contact in dormitories (27.5%), but the rates were largely different between dormitories with different infrastructural or lifestyle features and infection control measures among residents. With appropriate infection control measures, the secondary transmission risk in dormitories was adequately suppressed. The household transmission rate (12.6%) was as high as that of close contact outside the residences (11.3%) and accounted for > 60% of the current rate of COVID-19 transmission among non-adults. Household transmission rates synchronized to local epidemics with changed local capacity of quarantining infectious patients. In conclusion, a group living environment is a significant risk factor of secondary transmission. Appropriate infection control measures and quarantine of infectious residents will decrease the risk of secondary transmission in group living environments.

  32. Treatment of COVID-19-Related Olfactory Disorder Promoted by Kakkontokasenkyushin'i: A Case Series.

    Shin Takayama, Ryutaro Arita, Rie Ono, Natsumi Saito, Satoko Suzuki, Akiko Kikuchi, Minoru Ohsawa, Yasunori Tadano, Tetsuya Akaishi, Junichi Tanaka, Takeshi Kanno, Michiaki Abe, Ko Onodera, Tadashi Ishii

    The Tohoku journal of experimental medicine　254　(2)　71-80　2021/06

    DOI： 10.1620/tjem.254.71 　

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    Olfactory disorders are one of the characteristic symptoms of the coronavirus disease of 2019 (COVID-19), which causes infection and inflammation of the upper and lower respiratory tract. To our knowledge, there are no treatments for COVID-19-related olfactory disorder. Here, we report five olfactory disorder cases in COVID-19, treated using the Japanese traditional (Kampo) medicine, kakkontokasenkyushin'i. We treated five patients with mild COVID-19 at an isolation facility using Kampo medicine, depending on their symptoms. Patients with the olfactory disorder presented with a blocked nose, nasal discharge or taste impairment. Physical examination using Kampo medicine showed similar findings, such as a red tongue with red spots and sublingual vein congestion, which presented as blood stasis and inflammation; thus, we prescribed the Kampo medicine, kakkontokasenkyushin'i. After administration, the numeric rating scale scores of the smell impairment improved within 3 days from 9 to 3 in case 1, from 10 to 0 in case 2, from 9 to 0 in case 3, from 5 to 0 in case 4, and from 9 to 0 within 5 days in case 5. Following the treatment, other common cold symptoms were also alleviated. Kakkontokasenkyushin'i can be used for treating nasal congestion, rhinitis, and inflammation in the nasal mucosa. The olfactory disorder in COVID-19 has been reportedly associated with inflammation and congestion, especially in the olfactory bulb and olfactory cleft. Kakkontokasenkyushin'i may be one of the treatment alternatives for the olfactory disorder with rhinitis in patients with COVID-19.

  33. Restoration of clean water supply and toilet hygiene reduces infectious diseases in post-disaster evacuation shelters: A multicenter observational study

    Tetsuya Akaishi, Kazuma Morino, Yoshikazu Maruyama, Satoru Ishibashi, Shin Takayama, Michiaki Abe, Takeshi Kanno, Yasunori Tadano, Tadashi Ishii

    Heliyon　7　(5)　e07044-e07044　2021/05

    Publisher: Elsevier BV

    DOI： 10.1016/j.heliyon.2021.e07044 　

    ISSN： 2405-8440

  34. Correction to: Genome-wide association study identifies new loci for albuminuria in the Japanese population.

    Hiroshi Okuda, Koji Okamoto, Michiaki Abe, Kota Ishizawa, Satoshi Makino, Osamu Tanabe, Junichi Sugawara, Atsushi Hozawa, Kozo Tanno, Makoto Sasaki, Gen Tamiya, Masayuki Yamamoto, Sadayoshi Ito, Tadashi Ishii

    Clinical and experimental nephrology　25　(5)　565-565　2021/05

    DOI： 10.1007/s10157-021-02053-4 　

  35. Retrospective study revealed that Zn relate to improvement of swallowing function in the older adults. International-journal

    Yumika Seki, Kota Ishizawa, Tetsuya Akaishi, Michiaki Abe, Koji Okamoto, Junichi Tanaka, Ryutaro Arita, Shin Takayama, Akiko Kikuchi, Mariko Miyazaki, Hideo Harigae, Mayumi Sato, Masaya Hoshi, Kazuaki Hatsugai, Tadashi Ishii

    BMC geriatrics　21　(1)　279-279　2021/04/26

    DOI： 10.1186/s12877-021-02224-8 　

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    BACKGROUND: Zinc is an essential micronutrient for maintaining biological activity. The level of zinc in the blood is known to decrease with age, especially in those over 75 years of age. In older adults patients with impaired functional status, aspiration pneumonia based on dysphagia often becomes problematic. However, the relationship between zinc deficiency and swallowing function has not been studied before. METHODS: A total of 52 older adults subjects (15 males and 37 females) living in a nursing home were enrolled for this study. At the time of enrollment, data of gender, age, body weight, serum zinc levels, serum albumin levels, and the time in a simple 2-step swallowing provocation test (S-SPT) were collected. In patients with serum zinc levels < 60 μg/dL, we initiated 2 months of oral zinc supplementation therapy with a 34 mg/day zinc load. Those who underwent zinc supplementation were re-evaluated after the treatment period and serum zinc levels and S-SPT time were measured. RESULTS: At the time of enrollment, serum zinc level was significantly correlated with serum albumin levels (Pearson's R = 0.58, p < 0.0001) and time in the S-SPT (Spearman's rho = - 0.32, p = 0.0219). Twenty-five of the 52 patients had zinc deficiency with a serum zinc level < 60 μg/dL. After 2 months of oral zinc supplementation, both serum zinc levels (p < 0.0001) and time in the S-SPT (p = 0.04) significantly improved. Meanwhile, serum albumin level (p = 0.48) or body weight (p = 0.07) did not significantly change following zinc supplementation. Zinc supplementation significantly improved swallowing function, especially in the older adults who had comorbid dysphagia and zinc deficiency. CONCLUSIONS: Zinc deficiency is associated with compromised swallowing function in older adults patients with impaired general functions. Oral zinc supplementation can alleviate dysphagia in older adults patients with zinc deficiency even though this is a retrospective study. Further study will be needed to confirm this positive effect.

  36. Clinical trial monitoring effectiveness: Remote risk-based monitoring versus on-site monitoring with 100% source data verification. International-journal

    Osamu Yamada, Shih-Wei Chiu, Munenori Takata, Michiaki Abe, Mutsumi Shoji, Eri Kyotani, Chiyo Endo, Minami Shimada, Yuko Tamura, Takuhiro Yamaguchi

    Clinical trials (London, England)　18　(2)　158-167　2021/04

    DOI： 10.1177/1740774520971254 　

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    BACKGROUND/AIMS: Traditional on-site monitoring of clinical trials via frequent site visits and 100% source data verification is cost-consuming, and it still cannot guarantee data quality effectively. Depending on the types and designs of clinical trials, an alternative would be combining several monitoring methods, such as risk-based monitoring and remote monitoring. However, there is insufficient evidence of its effectiveness. This research compared the effectiveness of risk-based monitoring with a remote monitoring system with that of traditional on-site monitoring. METHODS: With a cloud-based remote monitoring system called beagle View®, we created a remote risk-based monitoring methodology that focused only on critical data and processes. We selected a randomized controlled trial conducted at Tohoku University Hospital and randomly sampled 11 subjects whose case report forms had already been reviewed by data managers. Critical data and processes were verified retrospectively by remote risk-based monitoring; later, all data and processes were confirmed by on-site monitoring. We compared the ability of remote risk-based monitoring to detect critical data and process errors with that of on-site monitoring with 100% source data verification, including an examination of clinical trial staff workload and potential cost savings. RESULTS: Of the total data points (n = 5617), 19.7% (n = 1105, 95% confidence interval = 18.7-20.7) were identified as critical. The error rates of critical data detected by on-site monitoring, remote risk-based monitoring, and data review by data managers were 7.6% (n = 84, 95% CI = 6.2-9.3), 7.6% (n = 84, 95% confidence interval = 6.2-9.3), and 3.9% (n = 43, 95% confidence interval = 2.9-5.2), respectively. The total number of critical process errors detected by on-site monitoring was 14. Of these 14, 92.9% (n = 13, 95% confidence interval = 68.5-98.7) and 42.9% (n = 6, 95% confidence interval = 21.4-67.4) of critical process errors were detected by remote risk-based monitoring and data review by data managers, respectively. The mean time clinical trial staff spent dealing with remote risk-based monitoring was 9.9 ± 5.3 (mean ± SD) min per visit per subject. Our calculations show that remote risk-based monitoring saved between 9 and 41 on-site monitoring visits, corresponding to a cost of between US$13,500 and US$61,500 per trial site. CONCLUSION: Remote risk-based monitoring was able to detect critical data and process errors as well as on-site monitoring with 100% source data verification, saving travel time and monitoring costs. Remote risk-based monitoring offers an effective alternative to traditional on-site monitoring of clinical trials.

  37. Early Treatment Initiation With Oral Prednisolone for Relapse Prevention Alleviates Depression and Fatigue in Aquaporin-4–Positive Neuromyelitis optica Spectrum Disorder

    Tetsuya Akaishi, Toshiyuki Takahashi, Kazuo Fujihara, Tatsuro Misu, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Michiaki Abe, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima

    Frontiers in Neurology　12　2021/02/22

    DOI： 10.3389/fneur.2021.608149 　

    eISSN： 1664-2295

  38. Predictors of SARS-CoV-2 Positivity Based on RT-PCR Swab Tests at a Drive-Through Outpatient Clinic for COVID-19 Screening in Japan.

    Tadashi Ishii, Shigeki Kushimoto, Yukio Katori, Shigeo Kure, Kaoru Igarashi, Motoo Fujita, Shin Takayama, Michiaki Abe, Junichi Tanaka, Akiko Kikuchi, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tetsuya Akaishi

    The Tohoku journal of experimental medicine　253　(2)　101-108　2021/02

    DOI： 10.1620/tjem.253.101 　

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    In response to the COVID-19 pandemic caused by SARS-CoV-2 in 2020, we conducted drive-through nasopharyngeal swab testing for COVID-19 in Sendai city, Japan, since April 2020. All tested individuals were judged in advance by public health centers for the necessity of undergoing the test with possible contact history and/or symptoms suggestive of COVID-19. In this study, to identify the predictors of SARS-CoV-2 test positivity for more efficient and evidenced selection of suspected individuals, we enrolled 3,540 consecutive individuals, tested in the first 7 months of the testing program, with data regarding to the history of close contact with COVID-19 patients, including those involved in cluster outbreaks. This cohort included 284 foreign students (257 males and 27 females) from a vocational school involved in the largest cluster outbreak in the area. Close contact history was present in 952 (26.9%) of the participants. The reverse transcription-polymerase chain reaction (RT-PCR) test results showed that 164 participants (4.6%) were positive and 3,376 participants (95.4%) were negative for the SARS-CoV-2 nucleocapsid gene (N2). In the univariate and multivariate analyses, history of close contact with COVID-19 patients, higher age, cough symptoms, and non-native ethnicity were predictors for SARS-CoV-2 test positivity. However, the significance of age and foreign nationality disappeared or declined upon excluding the foreign students from the aforementioned largest cluster outbreak. In conclusion, a history of close contact with COVID-19 patients and the presence of cough symptoms are significant predictors of SARS-CoV-2 test positivity.

  39. Impact of comorbid Sjögren syndrome in anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorders

    Tetsuya Akaishi, Toshiyuki Takahashi, Kazuo Fujihara, Tatsuro Misu, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Michiaki Abe, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima

    Journal of Neurology　2021/01/08

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s00415-020-10377-6 　

    ISSN： 0340-5354

    eISSN： 1432-1459

  40. COVID-19 Transmission at Schools in Japan

    Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Noriko Sugawara, Kaoru Igarashi, Motoo Fujita, Shigeo Kure, Shin Takayama, Michiaki Abe, Junichi Tanaka, Akiko Kikuchi, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tadashi Ishii

    The Tohoku Journal of Experimental Medicine　255　(3)　239-246　2021

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.255.239 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  41. Discriminatory Value of Self-reported Olfactory Dysfunction in the Prediction of Coronavirus Disease 2019

    Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Shigeo Kure, Kaoru Igarashi, Motoo Fujita, Shin Takayama, Michiaki Abe, Akiko Kikuchi, Junichi Tanaka, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tadashi Ishii

    Internal Medicine　60　(18)　2905-2910　2021

    Publisher: Japanese Society of Internal Medicine

    DOI： 10.2169/internalmedicine.7238-21 　

    ISSN： 0918-2918

    eISSN： 1349-7235

  42. Impacts of Natural Environmental Factors and Prevalence of Airway Symptoms on the Local Spread of COVID-19: A Time-Series Analysis in Regional COVID-19 Epidemics

    Tadashi Ishii, Shigeki Kushimoto, Yukio Katori, Shigeo Kure, Kaoru Igarashi, Motoo Fujita, Noriko Sugawara, Shin Takayama, Michiaki Abe, Junichi Tanaka, Akiko Kikuchi, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tetsuya Akaishi

    The Tohoku Journal of Experimental Medicine　254　(2)　89-100　2021

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.254.89 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  43. Somatic symptoms with psychogenic or psychiatric background: Characteristics and pitfalls

    Tetsuya Akaishi, Michiaki Abe, Atsuko Masaura, Junichi Tanaka, Shin Takayama, Ko Onodera, Takehiro Numata, Kota Ishizawa, Satoko Suzuki, Minoru Ohsawa, Takeshi Kanno, Tadashi Ishii

    Journal of Family Medicine and Primary Care　10　(2)　1021-1021　2021

    Publisher: Medknow

    DOI： 10.4103/jfmpc.jfmpc_1100_20 　

    ISSN： 2249-4863

  44. Predictors of SARS-CoV-2 Positivity Based on RT-PCR Swab Tests at a Drive-Through Outpatient Clinic for COVID-19 Screening in Japan

    Tadashi Ishii, Shigeki Kushimoto, Yukio Katori, Shigeo Kure, Kaoru Igarashi, Motoo Fujita, Shin Takayama, Michiaki Abe, Junichi Tanaka, Akiko Kikuchi, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tetsuya Akaishi

    The Tohoku Journal of Experimental Medicine　253　(2)　101-108　2021

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.253.101 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  45. Seasonal variation of onset in patients with anti-aquaporin-4 antibodies and anti-myelin oligodendrocyte glycoprotein antibody. International-journal

    Tetsuya Akaishi, Juichi Fujimori, Toshiyuki Takahashi, Tatsuro Misu, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Ryo Ogawa, Michiaki Abe, Tadashi Ishii, Masashi Aoki, Kazuo Fujihara, Ichiro Nakashima

    Journal of neuroimmunology　349　577431-577431　2020/12/15

    DOI： 10.1016/j.jneuroim.2020.577431 　

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    This study aimed to determine the seasonal impact on the clinical onset of inflammatory neurological diseases of the central nervous system by analyzing the onset month with information on clinical manifestations in Japanese patients. As a result, patients with anti-aquaporin-4 antibodies (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (NMOSD) showed spring-summer predominance of the clinical onset. Conversely, patients with anti-myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease showed autumn-winter predominance of the clinical onset. Both seasonal variations were irrespective of the clinical manifestation. Environmental factors with seasonal variation influence the development of neurological conditions related to AQP4-IgG and MOG-IgG.

  46. 腎動脈エコー検査による腎動脈血流評価と年齢・腎機能・血圧との関連について

    阿部 倫明, 赤石 哲也, 石沢 興太, 三木 俊, 三木 未佳, 船水 康陽, 新谷 香織, 高山 真, 石井 正

    超音波医学　47　(Suppl.)　S534-S534　2020/11

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  47. 腎動脈エコー検査による腎動脈血流評価と年齢・腎機能・血圧との関連について

    阿部 倫明, 赤石 哲也, 石沢 興太, 三木 俊, 三木 未佳, 船水 康陽, 新谷 香織, 高山 真, 石井 正

    超音波医学　47　(Suppl.)　S534-S534　2020/11

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  48. Penetration of a swallowed fish bone into pulmonary vein: diagnosis and management. International-journal

    Tetsuya Akaishi, Kota Ishizawa, Toshiaki Fukutomi, Yasuchika Yamamoto, Hirofumi Ichikawa, Suguru Watanabe, Naoko Mori, Mayuko Saito, Shin Takayama, Michiaki Abe, Kazuaki Hatsugai, Tadashi Ishii

    Heliyon　6　(11)　e05611　2020/11

    DOI： 10.1016/j.heliyon.2020.e05611 　

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    We present a case of a 71-year-old woman who accidently swallowed a large fish bone that penetrated into the pulmonary vein. She visited the hospital the next day with a complaint of mild chest discomfort with slight pain and fever of 37.4 °C. Contrast-enhanced chest computed tomography (CT) scan revealed a large fish bone with a length of 35 mm impacted in the middle esophagus. The bone had penetrated into the pulmonary vein, causing mediastinitis. Blood tests revealed elevation in the white blood cell count and C-reactive protein level. Because intractable bleeding from pulmonary vein after endoscopic removal can be lethal, endoscopic removal of the fish bone in an operating room under general anesthesia with cardiovascular surgical standby for possible emergency surgery was selected. After endoscopic removal, mediastinal hematoma was absent with a follow-up chest CT scan, and the mediastinitis was treated with intravenous antibiotics. The patient shortly became afebrile with normalized blood test findings. After confirming the normal findings on the follow-up chest CT scan and endoscopic inspection in the next week, she was discharged from the hospital 10 days after hospitalization without any complications. When the swallowed bone penetrates into the major pericardial vessels, unprepared endoscopic removal may result in fatal sequelae such as intractable mediastinal hemorrhage. Urgent consultation with cardiovascular or thoracic surgeons for a possible emergent surgery is needed before endoscopic removal is attempted.

  49. Rapid Administration of High-Dose Intravenous Methylprednisolone Improves Visual Outcomes After Optic Neuritis in Patients With AQP4-IgG-Positive NMOSD

    Tetsuya Akaishi, Takayuki Takeshita, Noriko Himori, Toshiyuki Takahashi, Tatsuro Misu, Ryo Ogawa, Kimihiko Kaneko, Juichi Fujimori, Michiaki Abe, Tadashi Ishii, Kazuo Fujihara, Masashi Aoki, Toru Nakazawa, Ichiro Nakashima

    FRONTIERS IN NEUROLOGY　11　2020/09

    DOI： 10.3389/fneur.2020.00932 　

    ISSN： 1664-2295

  50. Orengedokuto and shosaikoto for intractable intracranial carmustine implant-induced fever in a patient with brain tumor: A case report. International-journal

    Satoko Suzuki, Shin Takayama, Akiko Kikuchi, Ryutaro Arita, Michiaki Abe, Ryuta Saito, Masayuki Kanamori, Teiji Tominaga, Tadashi Ishii

    Explore (New York, N.Y.)　17　(3)　236-238　2020/08/28

    DOI： 10.1016/j.explore.2020.08.014 　

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    INTRODUCTION: Anaplastic astrocytoma has a dismal prognosis with conventional treatment. Multidisciplinary treatment is needed to control the disease; however, side effects of the treatment reduce a patient's quality of life (QOL). Carmustine-impregnated wafers (Gliadel®, Eisai Co., Ltd., Tokyo, Japan), one of the treatment modalities for anaplastic astrocytoma, has been reported to have drug-induced fever as a side effect. CASE REPORT: A 36-year-old man underwent excision for a recurrent brain tumor. Histopathological examination established a diagnosis of anaplastic astrocytoma and an intracranial carmustine implant was placed for local chemotherapy. Postoperatively, the patient developed high fever, which could not be controlled using antipyretics. The high fever ameliorated dramatically after the administration of Kampo medicines, specifically orengedokuto and shosaikoto, and the patient could continue chemotherapy. CONCLUSION: To the best of our knowledge, this is the first report of successful treatment of intractable carmustine implant-induced fever using Kampo medicine. In this case, Kampo medicine led to an improvement of QOL.

  51. Progressive patterns of neurological disability in multiple sclerosis and neuromyelitis optica spectrum disorders. International-journal Peer-reviewed

    Tetsuya Akaishi, Toshiyuki Takahashi, Tatsuro Misu, Michiaki Abe, Tadashi Ishii, Juichi Fujimori, Masashi Aoki, Kazuo Fujihara, Ichiro Nakashima

    Scientific reports　10　(1)　13890-13890　2020/08/17

    DOI： 10.1038/s41598-020-70919-w 　

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    The progressive patterns of neurological disability in multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) and the significance of clinical relapses to the progressions of neurological disability in these diseases have not been fully elucidated. In this study, to elucidate the impact of relapses to the progression of accumulated neurological disability and to identify the factors to affect the progression of neurological disability in MS and NMOSD, we followed 62 consecutive MS patients and 33 consecutive NMOSD patients for more than 5 years with the clinical symptoms, relapse occurrence, and Expanded Disability Status Scale (EDSS) in the chronic phase. All enrolled MS patients were confirmed to be negative for serum anti-myelin oligodendrocyte glycoprotein antibody. As a result, patients with NMOSD showed significantly severer neurological disability at 5 years from onset than MS patients. Progression in EDSS score was almost exclusively seen after clinical attacks in NMOSD, whereas progression could be observed apart from relapses in MS. Neurological disability did not change without attacks in NMOSD, whereas it sometimes spontaneously improved or deteriorated apart from relapses in MS (p < 0.001). In patients with MS, those with responsible lesions primarily in spinal cord were more likely to show such spontaneous improvement. In conclusion, clinical deterioration in NMOSD patients is irreversible and almost exclusively takes place at the timing of clinical attacks with stepwise accumulation of neurological disability. Meanwhile, changes in EDSS score can be seen apart from relapses in MS patients. Neurological disability in MS patients is partly reversible, and the patients with disease modifying drugs sometimes present spontaneous improvement of the neurological disability.

  52. Genome-wide association study identifies new loci for albuminuria in the Japanese population. Peer-reviewed

    Hiroshi Okuda, Koji Okamoto, Michiaki Abe, Kota Ishizawa, Satoshi Makino, Osamu Tanabe, Junichi Sugawara, Atsushi Hozawa, Kozo Tanno, Makoto Sasaki, Gen Tamiya, Masayuki Yamamoto, Sadayoshi Ito, Tadashi Ishii

    Clinical and experimental nephrology　24　(8)　1-9　2020/08

    DOI： 10.1007/s10157-020-01884-x 　

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    BACKGROUND: Urinary albumin excretion (UAE) is a risk factor for cardiovascular diseases, metabolic syndrome, chronic kidney disease, etc. Only a few genome-wide association studies (GWAS) for UAE have been conducted in the European population, but not in the Asian population. Here we conducted GWAS and identified several candidate genes harboring single nucleotide polymorphisms (SNPs) responsible for UAE in the Japanese population. METHODS: We conducted GWAS for UAE in 7805 individuals of Asian ancestry from health-survey data collected by Tohoku Medical Megabank Organization (ToMMo) and Iwate Tohoku Medical Megabank Organization (IMM). The SNP genotype data were obtained with a SNP microarray. After imputation using a haplotype panel consisting of 2000 genome sequencing, 4,962,728 SNP markers were used for the GWAS. RESULTS: Eighteen SNPs at 14 loci (GRM7, EXOC1/NMU, LPA, STEAP1B/RAPGEF5, SEMA3D, PRKAG2, TRIQK, SERTM1, TPT1-AS1, OR5AU1, TSHR, FMN1/RYR3, COPRS, and BRD1) were associated with UAE in the Japanese individuals. A locus with particularly strong associations was observed on TSHR, chromosome 14 [rs116622332 (p = 3.99 × 10-10)]. CONCLUSION: In this study, we successfully identified UAE-associated variant loci in the Japanese population. Further study is required to confirm this association.

  53. Scalp lymphangiosarcoma: A distinct skin manifestation of edematous erythema on face and scalp without subcutaneous hemorrhage or preceding condition of lymphedema. International-journal Peer-reviewed

    Hiromi Suzuki, Kenshi Yamasaki, Shin Takayama, Michiaki Abe, Tadashi Ishii, Setsuya Aiba

    The Journal of dermatology　2020/07/16

    DOI： 10.1111/1346-8138.15482 　

  54. Psoriatic arthritis with skin lesions localized to the scalp: A case report

    Tetsuya Akaishi, Kenshi Yamasaki, Yu Mori, Toshiya Takahashi, Takuya Izumiyama, Hitoshi Terui, Michiaki Abe, Shin Takayama, Setsuya Aiba, Tadashi Ishii

    Journal of General and Family Medicine　2020/07/08

    Publisher: Wiley

    DOI： 10.1002/jgf2.358 　

    ISSN： 2189-7948

    eISSN： 2189-7948

  55. Impact of intrathecal IgG synthesis on neurological disability in patients with multiple sclerosis. International-journal Peer-reviewed

    Tetsuya Akaishi, Toshiyuki Takahashi, Kazuo Fujihara, Tatsuro Misu, Shuhei Nishiyama, Yoshiki Takai, Juichi Fujimori, Michiaki Abe, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima

    Multiple sclerosis and related disorders　45　102382-102382　2020/07/07

    DOI： 10.1016/j.msard.2020.102382 　

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    BACKGROUND: The association between routine laboratory findings, including cerebrospinal fluid biomarkers, and neurological outcomes in patients with multiple sclerosis (MS) has not been fully elucidated. In this study, we evaluated blood and cerebrospinal fluid (CSF) analysis results at diagnosis and before treatment in patients with MS and assessed their correlations with neurological outcomes. MATERIALS AND METHODS: In this study, 38 consecutive patients with MS (36 with relapsing-remitting MS and 2 with primary progressive MS) were recruited. Before treatment, all patients underwent routine CSF analysis at the time of diagnosis, including evaluation of albumin and immunoglobulin G (IgG) levels. The association between laboratory data and neurological outcomes was comprehensively evaluated. Subsequent neurological outcome was assessed by using the Expanded Disability Status Scale (EDSS) score at 1 year and 5 years after diagnosis and relapse frequency in the first year and in the first 5 years. RESULTS: The IgG level in the CSF (rho = 0.46, p = 0.004), oligoclonal band count (rho = 0.61, p = 0.006), ratio of IgG and total protein in CSF (rho = 0.59, p < 0.0001), and ratio of IgG and albumin in CSF (rho = 0.67, p < 0.0001) showed moderate to strong correlations with the subsequent EDSS score 1 year after diagnosis. These variables still showed significant correlations with EDSS 5 years later. Albumin and lactate dehydrogenase levels in CSF did not correlate with the subsequent EDSS score. Relapse frequency did not correlate with any of the studied serum and CSF biomarkers. CONCLUSION: IgG levels in CSF at MS diagnosis are significantly correlated with the level of neurological disability independent of the relapse frequency. Markers of intrathecal IgG synthesis, such as the IgG index, are useful in estimating the present and subsequent clinical severity in patients with MS.

  56. ピア評価に注目した医療面接実習に関するアンケート調査

    田中 淳一, 有田 龍太郎, 齋藤 奈津美, 鈴木 聡子, 赤石 哲也, 高山 真, 阿部 倫明, 石井 正

    医学教育　51　(Suppl.)　102-102　2020/07

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  57. 住民コホートを使った尿中アルブミン排泄量に関する量的形質遺伝子座の検討

    岡本 好司, 奥田 拓史, 石井 正, 佐々木 真理, 田宮 元, 山本 雅之, 阿部 倫明

    日本腎臓学会誌　62　(4)　261-261　2020/07

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  58. 住民コホートを使った尿中アルブミン排泄量に関する量的形質遺伝子座の検討

    岡本 好司, 奥田 拓史, 石井 正, 佐々木 真理, 田宮 元, 山本 雅之, 阿部 倫明

    日本腎臓学会誌　62　(4)　261-261　2020/07

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  59. ピア評価に注目した医療面接実習に関するアンケート調査

    田中 淳一, 有田 龍太郎, 齋藤 奈津美, 鈴木 聡子, 赤石 哲也, 高山 真, 阿部 倫明, 石井 正

    医学教育　51　(Suppl.)　102-102　2020/07

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  60. Psoriatic arthritis with skin lesions localized to the scalp: A case report

    Tetsuya Akaishi, Kenshi Yamasaki, Yu Mori, Toshiya Takahashi, Takuya Izumiyama, Hitoshi Terui, Michiaki Abe, Shin Takayama, Setsuya Aiba, Tadashi Ishii

    JOURNAL OF GENERAL AND FAMILY MEDICINE　21　(6)　264-267　2020/07

    DOI： 10.1002/jgf2.358 　

    ISSN： 2189-7948

  61. Risk factors of attacks in neuromyelitis optica spectrum disorders. International-journal Peer-reviewed

    Tetsuya Akaishi, Toshiyuki Takahashi, Kazuo Fujihara, Tatsuro Misu, Michiaki Abe, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima

    Journal of neuroimmunology　343　577236-577236　2020/06/15

    DOI： 10.1016/j.jneuroim.2020.577236 　

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    Predisposing factors before the onset of neuromyelitis optica spectrum disorders (NMOSD) have not been systematically evaluated by now. We investigated the detailed pre-onset history in consecutive NMOSD patients. Thirteen of the enrolled 53 NMOSD patients (24.5%) had accompanying autoimmune diseases, such as Sjögren's syndrome. History of malignancy was seen in 8 of the 53 patients (15.1%). Recent history of non-neurological clinical episodes, such as systemic allergic reaction, systemic infection, surgical operation, or traumatic injury, was seen in 23 of the 53 patients (43.4%). NMOSD patients are likely to have pre-onset history of other autoimmune diseases, malignancy, or recent non-neurological systemic conditions, which may predispose or trigger the onset of NMOSD.

  62. Characteristics and course of patients treated with Kampo Medicine in the Department of General Medicine. Peer-reviewed

    Shin Takayama, Tetsuya Akaishi, Hiroyuki Nozaki, Satoko Suzuki, Ryutaro Arita, Natsumi Saito, Junichi Tanaka, Takehiro Numata, Akiko Kikuchi, Minoru Ohsawa, Michiaki Abe, Tadashi Ishii

    Journal of general and family medicine　21　(3)　48-55　2020/05

    DOI： 10.1002/jgf2.294 　

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    Background: A recent investigation reported that 92.7% Japanese family physicians have prescribed Kampo medicine (KM). KM can treat a wide variety of conditions from mental disorders to physical weaknesses. However, the characteristics and course of patients treated with KM at the Department of General Medicine remain unclear. Aims: To investigate the characteristics and course of patients treated with KM in our hospital. Methods: Data on medical history, complaints, course after Kampo treatment, and Hamilton Depression Rating Scale (HAM-D) scores were retrogradely collected. The background of patients who received Kampo treatment was compared to that of patients who did not. Result: Of 362 patients, 51 were treated with KM. Symptoms for which KM was prescribed included pain, general malaise, or sensory disturbance of extremities. All patients treated with KM were screened and initially diagnosed with a functional disorder or noncritical condition. KM including a crude drug of saiko such as hochuekkito, shigyakusan, shosaikoto, and yokukansan, was frequently prescribed for patients. Subjective symptoms showed improvement (53%) and no change (47%), while worsening was not observed in any patient. HAM-D scores showed that patients treated with KM had higher anxiety levels and related symptoms as well as a higher frequency of mental disorders prior to presenting at the hospital. Conclusion: Most complaints of the patients treated with KM were pain, general malaise, and sensory disturbance. KM is more likely to be prescribed in patients with health-related anxiety or a history of mental disorders.

  63. Osmotic pressure of serum and cerebrospinal fluid in patients with suspected neurological conditions. International-journal Peer-reviewed

    Tetsuya Akaishi, Toshiyuki Takahashi, Ichiro Nakashima, Michiaki Abe, Masashi Aoki, Tadashi Ishii

    Neural regeneration research　15　(5)　944-947　2020/05

    DOI： 10.4103/1673-5374.268906 　

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    Interstitial fluid movement in the brain parenchyma has been suggested to contribute to sustaining the metabolism in brain parenchyma and maintaining the function of neurons and glial cells. The pulsatile hydrostatic pressure gradient may be one of the driving forces of this bulk flow. However, osmotic pressure-related factors have not been studied until now. In this prospective observational study, to elucidate the relationship between osmolality (mOsm/kg) in the serum and that in the cerebrospinal fluid (CSF), we simultaneously measured the serum and CSF osmolality of 179 subjects with suspected neurological conditions. Serum osmolality was 283.6 ± 6.5 mOsm/kg and CSF osmolality was 289.5 ± 6.6 mOsm/kg. Because the specific gravity of serum and CSF is known to be 1.024-1.028 and 1.004-1.007, respectively, the estimated average of osmolarity (mOsm/L) in the serum and CSF covered exactly the same range (i.e., 290.5-291.5 mOsm/L). There was strong correlation between CSF osmolality and serum osmolality, but the difference in osmolality between serum and CSF was not correlated with serum osmolality, serum electrolyte levels, protein levels, or quotient of albumin. In conclusion, CSF osmolarity was suggested to be equal to serum osmolarity. Osmolarity is not one of the driving forces of this bulk flow. Other factors such as hydrostatic pressure gradient should be used to explain the mechanism of bulk flow in the brain parenchyma. This study was approved by the Institutional Review Board of the Tohoku University Hospital (approval No. IRB No. 2015-1-257) on July 29, 2015.

  64. Reno-protective effects of oral alkalizing agents in chronic kidney disease with aciduria: protocol for a randomized cohort study. International-journal Peer-reviewed

    Michiaki Abe, Tetsuya Akaishi, Mutsumi Shoji, Takuhiro Yamaguchi, Takashi Miki, Fumitoshi Satoh, Shin Takayama, Satomi Yamasaki, Kazuhiko Kawaguchi, Hiroshi Sato, Tadashi Ishii, Sadayoshi Ito

    BMC nephrology　21　(1)　144-144　2020/04/22

    DOI： 10.1186/s12882-020-01807-8 　

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    BACKGROUND: Aciduria caused by urinary excretion of acidic metabolic wastes produced in daily life is known to be augmented in patients with chronic kidney disease (CKD). To evaluate the reno-protective effect of oral alkalizing agents for the improvement of metabolic acidosis and neutralization of intratubular pH in the patients with mild stages of CKD. Also, to identify reno-protective surrogate markers in the serum and urine that can closely associate the effect of urine alkalization. METHODS: In this single-centered, open-labeled, randomized cohort study, patients with CKD stages G2, G3a and G3b, who visited and were treated at Tohoku University Hospital during the enrollment period were registered. We administered sodium bicarbonate or sodium-potassium citrate as the oral alkalinizing agents. A total of 150 patients with CKD will be randomly allocated into the following three groups: sodium bicarbonate, sodium-potassium citrate and standard therapy group without any alkalinizing agents. The data of performance status, venous blood test, spot urine test, venous blood-gas test, electrocardiogram, renal arterial ultrasonography and chest X-ray will be collected at 0, 6, 12 and 24 weeks (short-term study) from starting the interventions. These data will be also collected at 1 and 2 years (long-term study). The samples of plasma and serum and early-morning urine at every visit will be acquired for the analysis of renal function and surrogate uremic biomarkers. The recruitment for this cohort study terminated in March, 2018, and the follow-up period for all the enrolled subjects will be terminated in December, 2020. The primary endpoint will be the development of originally-defined significant renal dysfunction or the occurrence of any cerebrovascular disease in the short-term study. The secondary endpoint will be the same endpoints as in the long-term study, or the patients with significant changes in the suggested the surrogate biomarkers. DISCUSSION: The findings of this study will address the importance of taking oral alkalizing agents in the patients with early stages of CKD, furthermore they could address any new surrogate biomarkers that can be useful from early stage CKD. TRIAL REGISTRATION: Registered Report Identifier: UMIN000010059 and jRCT021180043. The trial registration number; 150. Date of registration; 2013/02/26.

  65. Late increases in dialysis initiation after a massive disaster. International-journal Peer-reviewed

    Michiaki Abe, Tetsuya Akaishi, Tadashi Ishii

    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy　2020/04/12

    DOI： 10.1111/1744-9987.13498 　

  66. Repeated follow-up of AQP4-IgG titer by cell-based assay in neuromyelitis optica spectrum disorders (NMOSD). International-journal Peer-reviewed

    Tetsuya Akaishi, Toshiyuki Takahashi, Ichiro Nakashima, Michiaki Abe, Tadashi Ishii, Masashi Aoki, Kazuo Fujihara

    Journal of the neurological sciences　410　116671-116671　2020/03/15

    DOI： 10.1016/j.jns.2020.116671 　

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    INTRODUCTION: Neuromyelitis optica spectrum disorder (NMOSD) is characterized by the presence of serum anti-aquaporin 4 (AQP4) antibody. However, the significance of changes in the serum titer as a marker of disease severity or relapse prediction is unknown. METHODS: We collected clinical data and serum antibody titers by cell-based assay from 45 NMOSD patients for whom more than one titer measurement taken in 6-12 month interval periods was available. The AQP4-IgG titer was measured by a live cell-based assay method, and the serum titer levels between the acute phase and preceding chronic phase were compared. In addition, we evaluated the correlation between the serum titer and relapse frequency while following the clinical course of the enrolled NMOSD patients. RESULTS: Serum AQP4-IgG titer was not elevated in the acute phase, compared to that of the preceding chronic phase, irrespective of the clinical phenotypes. Moreover, there was no correlation between the titer at onset and relapse frequency in 10 years post-onset or neurological disability at 5 and 10 years after onset. The titer was slightly elevated several months before relapses in about half of the cases, but the change was trivial and may not be applicable for clinical use. CONCLUSION: Although evaluating the positivity of serum AQP4-IgG at the onset is necessary, the titer level does not reflect the ongoing disease activity or the following neurological prognosis. Repeated follow-up of titer levels may not be useful for the management of NMOSD patients.

  67. Serum AQP4-IgG level is associated with the phenotype of the first attack in neuromyelitis optica spectrum disorders. International-journal Peer-reviewed

    Tetsuya Akaishi, Toshiyuki Takahashi, Noriko Himori, Kazuo Fujihara, Tatsuro Misu, Michiaki Abe, Tadashi Ishii, Toru Nakazawa, Masashi Aoki, Ichiro Nakashima

    Journal of neuroimmunology　340　577168-577168　2020/03/15

    DOI： 10.1016/j.jneuroim.2020.577168 　

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    We aimed in this study to elucidate the impact of serum AQP4-IgG titer before starting treatments to the clinical manifestation of neuromyelitis optica spectrum disorders (NMOSD). Serum titer at the onset, measured using live cell-based assay method, did not correlate to the subsequent relapse rate or neurological prognosis. Patients with optic neuritis as the first attack showed significantly higher serum titer than patients with acute myelitis or area postrema syndrome, although the titer did not correlate to the visual prognosis. The result implies that the pathological mechanism of optic neuritis and acute myelitis could be different in NMOSD.

  68. Clinical Usefulness of Endoscopy, Barium Fluoroscopy, and Chest Computed Tomography for the Correct Diagnosis of Achalasia. Peer-reviewed

    Tetsuya Akaishi, Toru Nakano, Tomomi Machida, Michiaki Abe, Shin Takayama, Ken Koseki, Takashi Kamei, Shin Fukudo, Tadashi Ishii

    Internal medicine (Tokyo, Japan)　59　(3)　323-328　2020/02/01

    DOI： 10.2169/internalmedicine.3612-19 　

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    Objective The definite diagnosis of esophageal achalasia is established using manometry, which is performed in patients with suspected achalasia based on the findings of screening examinations, such as upper gastrointestinal endoscopy, chest computed tomography (CT), or a barium swallow test. However, the exact values of test characteristics in these supportive diagnostic examinations remain unclear. Methods We estimated the sensitivity and specificity of characteristic findings in the supportive diagnostic examinations for achalasia by comparing the data of a large number of achalasia patients and others with digestive symptoms. Patients Achalasia patients (n=119) and non-achalasia patients with suspected achalasia and repeated feelings of chest discomfort (n=37) who were treated in a single university hospital. Results Characteristic findings on chest CT (i.e., dilated esophagus, air-fluid level formation) and barium swallow tests were observed in more than 80% of achalasia patients but in less than 10% of non-achalasia patients. In contrast, conventional characteristic findings of upper gastrointestinal endoscopy (i.e., intra-esophageal food debris, feeling of resistance at the esophagogastric junction) were seen in only 40-70% of achalasia patients. In particular, the feeling of resistance at the esophagogastric junction was observed by the examiner in only 30-50% of patients. Conclusion Intra-esophageal food debris or resistance at the esophagogastric junction on upper gastrointestinal endoscopy will be positive in only about half of patients with achalasia. Other supportive diagnostic examinations, such as chest CT or barium fluoroscopy, should therefore be included in order to avoid overlooking the disease.

  69. Rapid Administration of High-Dose Intravenous Methylprednisolone Improves Visual Outcomes After Optic Neuritis in Patients With AQP4-IgG-Positive NMOSD. International-journal

    Tetsuya Akaishi, Takayuki Takeshita, Noriko Himori, Toshiyuki Takahashi, Tatsuro Misu, Ryo Ogawa, Kimihiko Kaneko, Juichi Fujimori, Michiaki Abe, Tadashi Ishii, Kazuo Fujihara, Masashi Aoki, Toru Nakazawa, Ichiro Nakashima

    Frontiers in neurology　11　932-932　2020

    DOI： 10.3389/fneur.2020.00932 　

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    Objective: The purpose of this study was to elucidate the rapid impact of high-dose intravenous methylprednisolone pulse therapy (1,000 mg/day for 3 days) on the eventual visual prognosis in patients with serum anti-aquaporin-4 immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (NMOSDs) who had an attack of optic neuritis (ON). Methods: Data from 32 consecutive NMOSD patients (1 male and 31 female) with at least one ON attack, involving a total of 36 ON-involved eyes, were evaluated. The following variables at ON onset were evaluated: sex, age at the first ON episode, visual acuity at nadir, visual acuity after 1 year, duration from ON onset to treatment for an acute ON attack, cycles of high-dose intravenous methylprednisolone pulse therapy for the ON attack, and cycles of plasmapheresis for the ON attack. Among the 36 ON-involved eyes, 27 eyes were studied using orbital MRI with a short-T1 inversion recovery sequence and gadolinium-enhanced fat-suppressed T1 imaging before starting treatment in the acute phase. Results: In univariate analyses, a shorter duration from ON onset to the initiation of high-dose intravenous methylprednisolone pulse therapy favorably affected the eventual visual prognosis 1 year later (Spearman's rho = 0.50, p = 0.0018). The lesion length on orbital MRI was also correlated with the eventual visual prognosis (rho = 0.68, p < 0.0001). Meanwhile, the days to steroid pulse therapy and lesion length on orbital MRI did not show a significant correlation. These findings suggest that the rapidness of steroid pulse therapy administration affects the eventual visual prognosis independent of the severity of ON. In multivariate analysis, a shorter time from ON onset to the start of acute treatment (p = 0.0004) and a younger age at onset (p = 0.0071) were significantly associated with better visual outcomes. Conclusions: Rapid initiation of high-dose intravenous methylprednisolone pulse therapy is essential to preserve the eventual visual acuity in patients with serum AQP4-IgG-positive NMOSD. Once clinicians suspect acute ON with serum AQP4-IgG, swift administration of steroid pulse therapy before confirming the positivity of serum AQP4-IgG would be beneficial for preserving visual function.

  70. Number of MRI T1-hypointensity corrected by T2/FLAIR lesion volume indicates clinical severity in patients with multiple sclerosis. International-journal Peer-reviewed

    Tetsuya Akaishi, Toshiyuki Takahashi, Kazuo Fujihara, Tatsuro Misu, Shunji Mugikura, Michiaki Abe, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima

    PloS one　15　(4)　e0231225　2020

    DOI： 10.1371/journal.pone.0231225 　

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    INTRODUCTION: Progressive brain atrophy, development of T1-hypointense areas, and T2-fluid-attenuated inversion recovery (FLAIR)-hyperintense lesion formation in multiple sclerosis (MS) are popular volumetric data that are often utilized as clinical outcomes. However, the exact clinical interpretation of these volumetric data has not yet been fully established. METHODS: We enrolled 42 consecutive patients with MS who fulfilled the revised McDonald criteria of 2010. They were followed-up for more than 3 years from onset, and cross-sectional brain volumetry was performed. Patients with no brain lesions were excluded in advance from this study. For the brain volumetric data, we evaluated several parameters including age-adjusted gray-matter volume atrophy, age-adjusted white-matter volume atrophy, and T2-FLAIR lesion volume. The numbers of T1-hypointense and T2-FLAIR-hyperintense areas were also measured along the same timeline. The clinical data pertaining to disease duration, expanded disability status scale (EDSS), and MS severity score (MSSS) at the timing of volumetry were collected. RESULTS: Among the 42 patients with MS and brain lesions, the number of T1-hypointensity (rho = 0.51, p<0.001), gray-matter atrophy (rho = 0.40, p<0.01) and white-matter atrophy (rho = 0.49, p<0.001) correlated with the EDSS. T1-hypointensity count divided by FLAIR lesion volume correlated with the MSSS (rho = 0.60, p<0.001). Meanwhile, counts or volumes of FLAIR-hyperintense lesions were associated only with the times of past relapses, and did not correlate with present neurological disability level or ongoing disease activity. These findings were consistent regardless of the presence of spinal cord lesions. CONCLUSION: Numbers of T1-hypointensities and brain atrophy equally indicated the current neurological disability in MS. The number of T1-hypointensities divided by FLAIR lesion volume represented the clinical severity. The size or number of FLAIR lesions reflected earlier relapses but was not a good indicator of neurological disability or clinical severity.

  71. Neuromyelitis optica spectrum disorders with unevenly clustered attack occurrence. International-journal Peer-reviewed

    Tetsuya Akaishi, Ichiro Nakashima, Toshiyuki Takahashi, Michiaki Abe, Tadashi Ishii, Masashi Aoki

    Neurology(R) neuroimmunology & neuroinflammation　7　(1)　2020/01

    DOI： 10.1212/NXI.0000000000000640 　

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    OBJECTIVE: The aim of this study was to elucidate the characteristics of clinical attacks in neuromyelitis optica spectrum disorders (NMOSDs) with positive serum anti-aquaporin-4 antibody. Both the timing and sequential pattern of clinical types were analyzed. METHODS: A total of 69 patients with NMOSD were enrolled in this study, all of whom were treated at a single university hospital. All data regarding the clinical attacks (including types and date) together with other clinical information were collected. RESULTS: Analysis of clinical attacks from the enrolled patients showed that there were 2 distributional patterns of attack occurrence in each patient: (1) "clustered" occurrences, which occurred within 12 months from the previous attack, and (2) "nonclustered" intermittent occurrences, which occurred ≥12 months after the previous attack. These occurrences were regardless of the duration from the onset. During the "clustered" period, clinical attacks were more likely to show a similar clinical manifestation, such as optic neuritis or myelitis. After entering the "nonclustered" intermittent period, the relapses were of random clinical type, regardless of the previous clinical manifestation. CONCLUSIONS: Patients with NMOSD showed mixed periods of "clustered" occurrence with frequent attacks presenting with similar manifestations and "nonclustered" intermittent periods with sparse relapses. Approximately half of the relapses occurred during the "clustered" period within 12 months of the last clinical attack. Clinicians should pay special attention to whether the patients are presently in the "clustered" or "nonclustered" period to decide optimal relapse-preventive strategies.

  72. Preoperative risks of post-operative myasthenic crisis (POMC): A meta-analysis. International-journal Peer-reviewed

    Tetsuya Akaishi, Masakatsu Motomura, Hirokazu Shiraishi, Shunsuke Yoshimura, Michiaki Abe, Tadashi Ishii, Masashi Aoki

    Journal of the neurological sciences　407　116530-116530　2019/12/15

    DOI： 10.1016/j.jns.2019.116530 　

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    INTRODUCTION: Myasthenic crisis (MC) is a life-threatening condition in patients with myasthenia gravis (MG), for which thymectomy is known to be a predisposing factor. There are many preoperative factors that have been suggested to increase the occurrence of post-operative myasthenic crisis (POMC), but none have been unanimously concluded as definite risk factors. METHODS: We performed meta-analyses to assess preoperative risk factors for the occurrence of POMC in eligible case-control studies. RESULTS: A total of 10 articles were systematically reviewed and meta-analyses identified preoperative bulbar symptoms, a history of MC, and disease severity (p < .0001), as well as decreased vital capacity (p = .002), as risk factors for POMC. Among the identified risks, the presence of preoperative bulbar symptoms showed the least heterogeneity and was suggested to be the most reliable preoperative risks of POMC. CONCLUSION: Presence of preoperative bulbar symptoms is an easily discernable risk factor for the occurrence of POMC. A history of preoperative MC will further increase the risk of POMC. Patients with these risks require extra caution and should be closely monitored for POMC upon thymectomy.

  73. CD45+CD326+ Cells are Predictive of Poor Prognosis in Non-Small Cell Lung Cancer Patients. International-journal Peer-reviewed

    Kota Ishizawa, Mie Yamanaka, Yuriko Saiki, Eisaku Miyauchi, Shinichi Fukushige, Tetsuya Akaishi, Atsuko Asao, Takahiro Mimori, Ryota Saito, Yutaka Tojo, Riu Yamashita, Michiaki Abe, Akira Sakurada, Nhu-An Pham, Ming Li, Yoshinori Okada, Tadashi Ishii, Naoto Ishii, Seiichi Kobayashi, Masao Nagasaki, Masakazu Ichinose, Ming-Sound Tsao, Akira Horii

    Clinical cancer research : an official journal of the American Association for Cancer Research　25　(22)　6756-6763　2019/11/15

    DOI： 10.1158/1078-0432.CCR-19-0545 　

    ISSN： 1078-0432

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    PURPOSE: The epithelial-to-mesenchymal transition, the major process by which some cancer cells convert from an epithelial phenotype to a mesenchymal one, has been suggested to drive chemo-resistance and/or metastasis in patients with cancer. However, only a few studies have demonstrated the presence of CD45/CD326 doubly-positive cells (CD45/CD326 DPC) in cancer. We deployed a combination of cell surface markers to elucidate the phenotypic heterogeneity in non-small cell lung cancer (NSCLC) cells and identified a new subpopulation that is doubly-positive for epithelial and non-epithelial cell-surface markers in both NSCLC cells and patients' malignant pleural effusions. EXPERIMENTAL DESIGN: We procured a total of 39 patients' samples, solid fresh lung cancer tissues from 21 patients and malignant pleural effusion samples from 18 others, and used FACS and fluorescence microscopy to check their surface markers. We also examined the EGFR mutations in patients with known acquired EGFR mutations. RESULTS: Our data revealed that 0.4% to 17.9% of the solid tumor tissue cells and a higher percentage of malignant pleural effusion cells harbored CD45/CD326 DPC expressing both epithelial and nonepithelial surface markers. We selected 3 EGFR mutation patients and genetically confirmed that the newly identified cell population really originated from cancer cells. We also found that higher proportions of CD45/CD326 DPC are significantly associated with poor prognosis. CONCLUSIONS: In conclusion, varying percentages of CD45/CD326 DPC exist in both solid cancer tissue and malignant pleural effusion in patients with NSCLC. This CD45/CD326 doubly-positive subpopulation can be an important key to clinical management of patients with NSCLC.

  74. 経口アルカリ性化剤治療による早朝尿pHと随時尿pHの変動から腎保護効果をどう考えるか Peer-reviewed

    阿部 倫明, 赤石 哲也, 田中 淳一, 石沢 興太, 高山 真, 小野寺 浩, 石井 正

    日本病院総合診療医学会雑誌　15　(6)　583-583　2019/11

    Publisher: (一社)日本病院総合診療医学会

    ISSN： 2185-8136

  75. Consideration of gravity as a possible etiological factor in amyotrophic lateral sclerosis. International-journal Peer-reviewed

    Tetsuya Akaishi, Toshiyuki Takahashi, Michiaki Abe, Masashi Aoki, Tadashi Ishii

    Medical hypotheses　132　109369-109369　2019/11

    DOI： 10.1016/j.mehy.2019.109369 　

    ISSN： 0306-9877

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    Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with an unknown mechanism of onset that predominantly impairs the upper and lower motor neurons. Components of the sensory and autonomic nervous system were once thought to be spared in the disease, but more recently they have been identified to be impaired at various levels. However, some of the motor neurons such as oculomotor, abducens, or pudendal nerves are spared even in the later stages of ALS. The mechanism of such complex and heterogeneous neuronal loss in typical ALS is still unknown. In this study, the characteristics of the nervous system involved in the pathogenesis of ALS were comprehensively reviewed. As a result, the direction of the axon in the anatomical position, rather than the functional type or length of the axon, was suggested to contribute the most to the onset of ALS. This finding suggested that downward directed axons, represented by motor neurons, require extra energy to move waste or unnecessary substances from the synapse side to the neural cell body with retrograde fast axonal transport. Based on this theory, the extra energy that is required in vertically directed axons due to the effect of gravity was mathematically estimated. As a result, several percent more adenosine triphosphate molecules were suggested to be consumed in vertical axonal transport by gravity, compared to those consumed in transverse axonal transport. Because most of the motor neurons project downward in the anatomical position, unretrieved waste will gradually sediment in axon terminals by gravity, which could eventually result in motor neuron-dominant neuronal loss. Although the theory that gravity is one of the mechanisms responsible for ALS is still hypothetical, it is theoretically reasonable and compatible with the clinical manifestations of the disease. Further basic research studies with cultured neurons or animal models are necessary to confirm the association between gravity and the onset of ALS.

  76. Development of a medical education program with abdominal palpation simulators to support the understanding of traditional Japanese (kampo) medicine in beginners Peer-reviewed

    Ryutaro Arita, Takehiro Numata, Natsumi Saito, Shin Takayama, Takafumi Togashi, Soichiro Kaneko, Akiko Kikuchi, Minoru Ohsawa, Tetsuharu Kamiya, Michiaki Abe, Tadashi Ishii

    Traditional & Kampo Medicine　6　(3)　148-155　2019/10

    Publisher: Wiley

    DOI： 10.1002/tkm2.1230 　

  77. Application of Large Electronic Medical Database for Detecting Undiagnosed Patients in the General Population. Peer-reviewed

    Tadashi Ishii, Tetsuya Akaishi, Kenji Fujimori, Michiaki Abe, Masato Ohara, Mutsumi Shoji, Shin Takayama, Chiaki Sato, Masaharu Nakayama, Ichiro Tsuji, Toru Nakano, Noriaki Ohuchi, Takashi Kamei

    The Tohoku journal of experimental medicine　249　(2)　113-119　2019/10

    DOI： 10.1620/tjem.249.113 　

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    Clinical application of accumulated medical big data is a hot topic in medical informatics. Not only for suggesting possible diagnoses in each individual, large medical database can be possibly used for detecting undiagnosed patients in the general population. In this study, we tried to develop a computerized system of detecting overlooked undiagnosed patients with rare chronic diseases in the community population by utilizing the uniformed national medical insurance record database. A cumulative total of 489,823 hospital visits at one tertiary medical center were collected for this project. As the target disease, we selected esophagogastric junction outflow obstruction (EGJOO), including achalasia, which is known to be easily overlooked without performing a barium swallow test. Patient selection software automatically picked out 17,814 individuals with the given suspected diagnoses that could be misdiagnosed in patients with the target disease, from which the software further picked out 526 individuals who underwent upper endoscopy but did not undergo barium swallow test. Of them, the hospital medical records suggested that 39 people still suffered from prolonged symptoms lasting for more than 6 months after the first hospital visit. Among them, 16 individuals agreed to undergo the barium swallow test. One of them was confirmed to suffer from EGJOO, possibly based on some undiagnosed connective tissue diseases. An automated computerized detection system with uniform big medical data would realize more efficient and less expensive screening system for undiagnosed chronic diseases in the general population based on symptoms and previously performed examinations in each individual.

  78. Long-term assessment of intrarenal blood flow with Doppler ultrasonography for hypertensive patients after percutaneous transluminal renal angioplasty. International-journal Peer-reviewed

    Michiaki Abe, Kaori Araya, Tetsuya Akaishi, Takashi Miki, Mika Miki, Akira Sugawara, Takaaki Abe, Tadashi Ishii, Sadayoshi Ito

    Hypertension research : official journal of the Japanese Society of Hypertension　42　(10)　1649-1651　2019/10

    DOI： 10.1038/s41440-019-0272-0 　

    ISSN： 0916-9636

  79. The indole compound MA-35 attenuates tumorigenesis in an inflammation-induced colon cancer model. International-journal Peer-reviewed

    Keigo Kanehara, Shinobu Ohnuma, Yoshitake Kanazawa, Keisuke Sato, Shoji Kokubo, Hideyuki Suzuki, Hideaki Karasawa, Takehiro Suzuki, Chitose Suzuki, Takeshi Naitoh, Michiaki Unno, Takaaki Abe

    Scientific reports　9　(1)　12739-12739　2019/09/04

    DOI： 10.1038/s41598-019-48974-9 　

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    In inflammatory bowel disease, chronic inflammation results in the development of colon cancer known as colitis-associated cancer. This disease is associated with tumor necrosis factor-α (TNF-α) signaling. In addition, intestinal fibrosis is a common clinical complication that is promoted by transforming growth factor β1 (TGF-β1). In our previous study, MA-35 attenuated renal fibrosis by inhibiting both TNF-α and TGF-β1 signaling. This study aimed to identify the possible antitumor effects and antifibrotic effects of MA-35 using an AOM/DSS mouse model. MA-35 was orally administered every day for 70 days in the AOM/DSS mouse model. There was no difference in weight loss between the AOM/DSS group and the AOMDSS + MA-35 group, but the disease activity index score and the survival rate were improved by MA-35. MA-35 blocked the anemia and shortening of the colon induced by AOM/DSS. MA-35 reduced the macroscopic formation of tumors in the colon. In the microscopic evaluation, MA-35 reduced inflammation and fibrosis in areas with dysplasia. Furthermore, the TNF-α mRNA level in the colon tended to be reduced, and the interleukin 6, TGF-β1 and fibronectin 1 mRNA levels in the colon were significantly reduced by MA-35. These results suggested that MA-35 inhibited AOM/DSS-induced carcinogenesis by reducing inflammation and fibrosis.

  80. Sensitivity and specificity of meningeal signs in patients with meningitis. Peer-reviewed

    Tetsuya Akaishi, Junpei Kobayashi, Michiaki Abe, Kota Ishizawa, Ichiro Nakashima, Masashi Aoki, Tadashi Ishii

    Journal of general and family medicine　20　(5)　193-198　2019/09

    DOI： 10.1002/jgf2.268 　

    ISSN： 2189-6577

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    Background: Several types of physical examinations are used in the diagnosis of meningitis, including nuchal rigidity, jolt accentuation, Kernig's sign, and Brudzinski's sign. Jolt accentuation was reported to have sensitivity of nearly 100% and to be highly efficient for excluding meningitis, but more recent studies showed that a number of patients with meningitis may present negative in this test. Methods: We systematically reviewed studies on the above-mentioned physical examination tests and performed meta-analysis of their diagnostic characteristics to evaluate the clinical usefulness. Nine studies, comprising a total of 599 patients with pleocytosis in the cerebrospinal fluid (CSF) and 1216 patients without CSF pleocytosis, were enrolled in the analysis. Results: Jolt accentuation showed a decent level of odds ratio (3.62; 99% confidence interval (CI): 1.13-11.60, P = 0.004) comparable to that in nuchal rigidity (2.52; 1.21-5.27, P = 0.001) for the correct prediction of CSF pleocytosis among subjects with suspected meningitis. The estimated sensitivity was relatively high (40%-60%) in nuchal rigidity or jolt accentuation tests. On the other hand, Kernig's and Brudzinski's signs exhibited relatively low sensitivity (20%-30%). The estimated specificity was higher in Kernig's and Brudzinski's signs (85%-95%) than in nuchal rigidity or jolt accentuation tests (65%-75%). Conclusion: Approximately half of the patients with meningitis may not present typical meningeal signs upon physical examination. Combining several examinations for the detection of meningeal signs may decrease the risk of misdiagnosis.

  81. A 29-year-old Woman with Recurrent Pregnancy-induced Hypertension Based on Vascular Compression of the Medulla Oblongata. Peer-reviewed

    Tetsuya Akaishi, Hideyasu Kiyomoto, Michiaki Abe, Hiroshi Okuda, Kota Ishizawa, Toshiki Endo, Masahiro Miyata, Keisuke Nakayama, Sadayoshi Ito, Teiji Tominaga, Tadashi Ishii

    Internal medicine (Tokyo, Japan)　58　(15)　2257-2261　2019/08/01

    DOI： 10.2169/internalmedicine.2382-18 　

    ISSN： 0918-2918

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    We present a report of a 29-year-old woman with non-dipper type refractory hypertension due to the vascular compression of the medulla oblongata. The patient was diagnosed with hypertension at 17 years of age and underwent emergency Caesarean section at 26 weeks of gestation during 2 pregnancies due to severe high blood pressure. We suspected medullary compression by the curved posterior inferior cerebellar artery as the cause of her intractable hypertension, and she underwent Jannetta's decompression surgery. After the surgery, her blood pressure swiftly decreased to almost within the normal range, and her blood pressure pattern normalized to dipper type.

  82. Sensitivity and specificity of meningeal signs in patients with meningitis. Peer-reviewed

    Akaishi T, Kobayashi J, Abe M, Ishizawa K, Nakashima I, Aoki M, Ishii T

    J Gen Fam Med.　20　(5)　193-198　2019/07

  83. Spontaneous Regression of Recurrent Undifferentiated Carcinoma of the Endometrium. Peer-reviewed

    Tadashi Ishii, Shin Takayama, Michiaki Abe, Hitoshi Kuroda, Junichi Tanaka, Takehiro Numata, Akiko Kikuchi, Minoru Ohsawa, Souichiro Kaneko, Natsumi Saito, Ryutaro Arita, Yuko Itakura

    Internal medicine (Tokyo, Japan)　58　(11)　1649-1653　2019/06/01

    DOI： 10.2169/internalmedicine.0376-17 　

    ISSN： 0918-2918

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    We herein report a very rare case of spontaneous regression of recurrent undifferentiated carcinoma of the endometrium. An 80-year-old woman had undergone total hysterectomy with bilateral adnexectomy for undifferentiated carcinoma of the endometrium. The cancer recurred locally 10 months after surgery and then metastasized to the lung and liver. After she and her family elected to receive supportive care without active treatment, the local recurrences dramatically decreased, and the metastases of the lung, liver, and peritoneum also disappeared. This case showed that spontaneous regression can occur even with malignant tumors showing an extremely poor prognosis, such as undifferentiated carcinoma of the endometrium.

  84. 早朝尿pHと随時尿pHの違いに見た経口アルカリ性化剤による腎保護効果 Peer-reviewed

    阿部 倫明, 佐藤 文俊, 佐藤 博, 工藤 正孝, 森本 玲, 中道 崇, 小川 晋, 沼田 健裕, 清元 秀泰, 庄子 睦美, 三木 俊, 赤石 哲也, 石沢 興太, 石井 正, 伊藤 貞嘉

    日本腎臓学会誌　61　(3)　406-406　2019/05

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  85. The human central nervous system discharges carbon dioxide and lactic acid into the cerebrospinal fluid. International-journal Peer-reviewed

    Tetsuya Akaishi, Eiko Onishi, Michiaki Abe, Hiroaki Toyama, Kota Ishizawa, Michio Kumagai, Ryosuke Kubo, Ichiro Nakashima, Masashi Aoki, Masanori Yamauchi, Tadashi Ishii

    Fluids and barriers of the CNS　16　(1)　8-8　2019/03/29

    DOI： 10.1186/s12987-019-0128-7 　

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    BACKGROUND: The central nervous system was previously thought to draw oxygen and nutrition from the arteries and discharge carbon dioxide and other metabolic wastes into the venous system. At present, the functional role of cerebrospinal fluid in brain metabolism is not fully known. METHODS: In this prospective observational study, we performed gas analysis on venous blood and cerebrospinal fluid simultaneously acquired from 16 consecutive preoperative patients without any known neurological disorders. RESULTS: The carbon dioxide partial pressure (pCO2) (p < 0.0001) and lactic acid level (p < 0.001) in the cerebrospinal fluid were significantly higher than those in the peripheral venous blood, suggesting that a considerable proportion of metabolic carbon dioxide and lactic acid is discharged from the central nervous system into the cerebrospinal fluid. The oxygen partial pressure (pO2) was much higher in the cerebrospinal fluid than in the venous blood, corroborating the conventional theory of cerebrospinal fluid circulatory dynamics. The pCO2 of the cerebrospinal fluid showed a strong negative correlation with age (R = - 0.65, p = 0.0065), but the other studied variables did not show significant correlation with age. CONCLUSION: Carbon dioxide and lactic acid are discharged into the circulating cerebrospinal fluid, as well as into the venules. The level of carbon dioxide in the cerebrospinal fluid significantly decreased with age.

  86. High glucose level and angiotensin II type 1 receptor stimulation synergistically amplify oxidative stress in renal mesangial cells. International-journal Peer-reviewed

    Tetsuya Akaishi, Michiaki Abe, Hiroshi Okuda, Kota Ishizawa, Takaaki Abe, Tadashi Ishii, Sadayoshi Ito

    Scientific reports　9　(1)　5214-5214　2019/03/26

    DOI： 10.1038/s41598-019-41536-z 　

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    Oxidative stress in renal mesangial cell causes diabetic glomerular changes. High glucose levels and angiotensin II (Ang II) are known to stimulate superoxide production in renal mesangial cells. However, it has been unclear whether Ang II stimulation and pre-conditioning with high glucose affects the same pathway of superoxide production in renal mesangial cells or not. In this study, we examined the levels of oxidative stress under Ang II stimulation in renal mesangial cells preincubated for six hours at various glucose levels. Intracellular levels of reactive oxidative species (ROS) were measured using dihydroethidium or 5',6'-chloromethyl- 2',7' dichlorodihydro-fluorescein diacetate, which facilitates the detection of intracellular ROS under real-time fluorescent microscope. Ang II-induced elevated intracellular ROS levels were detected only when the cells were pre-incubated with high levels of glucose (13.5 mM, 27.8 mM), but was not detected under normal glucose condition (5.5 mM). Production of Ang II-induced intracellular ROS was higher under pre-treatment with 27.8 mM glucose compared to pretreatment with 13.5 mM glucose level. This ROS production in mesangial cells was induced within several minutes of the initiation of Ang II stimulation under high glucose levels. The production of intracellular ROS was significantly reduced in the presence of angiotensin II type1-receptor (AT1R) antagonist, whereas it was augmented in the presence of angiotensin II type2-receptor antagonist. In conclusion, Ang II-induced oxidative stress was augmented by high glucose levels and ROS levels were further alleviated in the presence of AT1R antagonists.

  87. Importance of Barium Swallow Test and Chest CT Scan for Correct Diagnosis of Achalasia in the Primary Care Setting. Peer-reviewed

    Tadashi Ishii, Tetsuya Akaishi, Michiaki Abe, Shin Takayama, Ken Koseki, Takashi Kamei, Toru Nakano

    The Tohoku journal of experimental medicine　247　(1)　41-49　2019/01

    DOI： 10.1620/tjem.247.41 　

    ISSN： 0040-8727

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    Esophageal achalasia is a disease characterized by the impaired esophageal peristalsis and non-relaxation of the lower esophageal sphincter muscle with unknown causes. Clinical manifestation of the disease is nonspecific (e.g., weight loss, vomiting, and persistent cough); namely, early diagnosis of the disease is often difficult. Delayed diagnosis of the disease is known to impair the patients' quality of life. Identifying the diagnostic factors that could cause diagnostic delay is needed. In this study, we collected data from 38 patients with achalasia and searched for diagnostic factors associated with delayed diagnosis (i.e., ≥ 6 months from the first hospital visit to diagnosis). The enrolled patients, diagnosed with achalasia based on esophageal manometry findings, had undergone surgical myotomy. As a result, the diagnosis of achalasia was likely to be delayed when the physician who had first contacted the patient did not perform a barium swallow test (p < 0.0001) or chest CT scan (p < 0.01) in a timely fashion. Among the patients with a delayed diagnosis (n = 15), none underwent a barium swallow test or chest CT within 6 months from their first hospital visit. The estimated sensitivities of diagnostic examinations for achalasia based on the enrolled 38 patients were higher than 80% for the barium swallow test and chest CT scan, but only 50-81% for endoscopy. To avoid the delayed diagnosis of achalasia, performing a barium swallow test or chest CT scan in a timely fashion, in addition to routine endoscopy, appears to be highly important.

  88. Influence of renal function and demographic data on intrarenal Doppler ultrasonography. International-journal Peer-reviewed

    Michiaki Abe, Tetsuya Akaishi, Takashi Miki, Mika Miki, Yasuharu Funamizu, Kaori Araya, Kota Ishizawa, Shin Takayama, Kei Takase, Takaaki Abe, Tadashi Ishii, Sadayoshi Ito

    PloS one　14　(8)　e0221244　2019

    DOI： 10.1371/journal.pone.0221244 　

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    Intrarenal Doppler ultrasonography is a non-invasive method to evaluate the renal blood flow in patients with renal arterial stenosis as well as chronic kidney diseases (CKD). Until recently, the relationship between ultrasonography findings and CKD stage has not been fully understood. Overall, 162 patients with CKD without apparent renal arterial stenosis were included in this study, and the pulsed-wave Doppler ultrasonography findings were evaluated in terms of the following parameters: peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive index (RI) at the renal arterial trunk, hilum, segmental, and interlobar regions. Age showed a significant negative correlation with the estimated glomerular filtration rate (eGFR), kidney size, and aortic PSV. Additionally, age showed a significant positive correlation with RI in all 4 regions. The eGFR showed a positive correlation with the aortic PSV and kidney size, but a negative correlation with RI. Both age and eGFR were found to be independently associated with aortic blood flow. On the intrarenal ultrasound, EDV and RI showed stronger correlations with eGFR than PSV, suggesting that the former indices would be better markers of renal function. In particular, the interlobar EDV was found to be the best index that reflects renal function. Although the RI is also a good marker of renal function, it is confounded by age; thus, its utility would be weaker than that of the EDV. In conclusion, intrarenal pulsed-wave Doppler ultrasonography is a useful tool to estimate and evaluate the renal function; the interlobar EDV may be the best index to estimate the effective perfusion and filtration of the kidneys.

  89. Low frequency of cervicocranial artery involvement in Japanese with renal artery fibromuscular dysplasia compared with that of Caucasians. Peer-reviewed

    Eikan Mishima, Shu Umezawa, Takehiro Suzuki, Miki Fujimura, Michiaki Abe, Junichiro Hashimoto, Takaaki Abe, Sadayoshi Ito

    Clinical and experimental nephrology　22　(6)　1294-1299　2018/12

    DOI： 10.1007/s10157-018-1575-1 　

    ISSN： 1342-1751

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    BACKGROUND: Fibromuscular dysplasia (FMD), which usually affects the renal artery, also affects the carotid, vertebral, and intracranial arteries. Previous studies have shown a high prevalence of concomitant renal artery and cervicocranial lesions in FMD patients. However, the analyzed subjects were mostly Caucasians in Western countries. METHOD: We performed a retrospective analysis to examine the prevalence of cervicocranial vascular lesions in Japanese FMD patients with renal artery involvement at a single institution. The presence of cervicocranial lesions was evaluated by Doppler echography and magnetic resonance angiography. We compared this prevalence with that reported in the literature. RESULT: Thirty-one Japanese FMD patients with renal artery lesions were studied. The mean age was 30 ± 12 years, 71% were women, and 16% were smokers; all patients were Asians and had hypertension. Multifocal, tubular, and unifocal types of renal lesions were found in 52, 35, and 13% of patients, respectively. Bilateral renal lesions were found in 13% of patients. None of the patients had a cervical vascular lesion associated with FMD. Only two patients (8%) had a lesion in the intracranial artery, of which one was a known case of moyamoya disease. CONCLUSION: These findings suggest that cervical artery involvement and intracranial artery involvement are not common in renal FMD patients in Japan, which is in contrast to the data reported for Caucasian patients in Western countries. Ethnic differences could influence the occurrence of cervicocranial lesions. A study with a larger sample size should be performed to validate these findings.

  90. Validity of Hamilton Depression Rating Scale for assessment of depressive state of new outpatients at a university hospital general medical unit Peer-reviewed

    ABE Michiaki

    14　(6)　556-563　2018/11

    Publisher:

    ISSN： 2185-8136

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    Accepted

  91. Canagliflozin reduces plasma uremic toxins and alters the intestinal microbiota composition in a chronic kidney disease mouse model. International-journal Peer-reviewed

    Mishima E, Fukuda S, Kanemitsu Y, Saigusa D, Mukawa C, Asaji K, Matsumoto Y, Tsukamoto H, Tachikawa T, Tsukimi T, Fukuda NN, Ho HJ, Kikuchi K, Suzuki C, Nanto F, Suzuki T, Ito S, Soga T, Tomioka Y, Abe T

    American journal of physiology. Renal physiology　315　(4)　F824-F833　2018/10

    DOI： 10.1152/ajprenal.00314.2017 　

    ISSN： 1931-857X

  92. 東北大学病院小児科におけるAlport症候群の診断契機と治療効果の検討 Peer-reviewed

    熊谷 直憲, 中山 真紀子, 内田 奈生, 工藤 宏紀, 木越 隆晶, 松木 琢磨, 新妻 創, 高橋 俊成, 阿部 倫明

    日本腎臓学会誌　60　(4)　561-566　2018/05

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  93. Novel biallelic mutations in the PNPT1 gene encoding a mitochondrial-RNA-import protein PNPase cause delayed myelination Peer-reviewed

    R. Sato, N. Arai-Ichinoi, A. Kikuchi, T. Matsuhashi, Y. Numata-Uematsu, M. Uematsu, Y. Fujii, K. Murayama, A. Ohtake, T. Abe, S. Kure

    Clinical Genetics　93　(2)　242-247　2018/02/01

    Publisher: Blackwell Publishing Ltd

    DOI： 10.1111/cge.13068 　

    ISSN： 1399-0004 0009-9163

  94. 東北大学病院総合診療外来における簡易心理検査の有用性と関連要因の検討 Peer-reviewed

    野崎 裕之, 中川 高, 阿部 倫明, 八木橋 真央, 甲賀 ひとみ, 吉村 直仁, 有田 龍太郎, 齊藤 奈津美, 田中 淳一, 沼田 健裕, 菅野 武, 鈴木 聡子, 大澤 稔, 菊池 章子, 黒田 仁, 高山 真, 奈良 正之, 富田 博秋, 石井 正

    総合病院精神医学　29　(Suppl.)　S-203　2017/11

    Publisher: (一社)日本総合病院精神医学会

    ISSN： 0915-5872

  95. Recommendation of Repeated Ammonia Tests for Intrahepatic Portal-Systemic Shunt Without Cirrhosis in Elderly Patients With Psychiatric Symptoms. International-journal Peer-reviewed

    Michiaki Abe, Temma Soga, Nobuya Obana, Kazumasa Seiji, Masao Tabata, Natsumi Saito, Ryutaro Arita, Takehiro Numata, Junichi Tanaka, Hitoshi Kuroda, Shin Takayama, Yutaka Kagaya, Tadashi Ishii

    Japanese clinical medicine　8　1179066017693597-1179066017693597　2017

    DOI： 10.1177/1179066017693597 　

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    We report an elderly male patient with hyperammonemia induced by intrahepatic portal-systemic shunt without cirrhosis (IPSSwoC). The occasional emergence of his erratic behaviors was misdiagnosed as a psychiatric disorder. Regardless of his uneven symptoms, IPSSwoC was suspected due to his hyperammonemia. The contrast computed tomography of the abdomen revealed a congenital type of IPSSwoC. As blood ammonia levels are inconstant, repeated blood tests are recommended when this disease is suspected in elderly patients with psychiatric symptoms.

  96. Improving the Quality of Postgraduate Education in Traditional Japanese Kampo Medicine for Junior Residents: An Exploratory Survey Conducted in Five Institutions in the Tohoku Area Peer-reviewed

    Shin Takayama, Seiichi Kobayashi, Soichiro Kaneko, Masao Tabata, Shinya Sato, Keiichi Ishikawa, Saya Suzuki, Ryutaro Arita, Natsumi Saito, Tetsuharu Kamiya, Hitoshi Nishikawa, Yuka Ikeno, Junichi Tanaka, Minoru Ohsawa, Akiko Kikuchi, Takehiro Numata, Hitoshi Kuroda, Michiaki Abe, Satoru Ishibashi, Nobuo Yaegashi, Tadashi Ishii

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　240　(3)　235-242　2016/11

    DOI： 10.1620/tjem.240.235 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  97. Preliminary study of the effects of orengedokuto on breath alcohol concentration. Peer-reviewed

    Suzuki S, Ojima T, Takayama S, Nakano Y, Nawa D, Saito N, Arita R, Kaneko S, Kamiya T, Mikami N, Kawamura T, Nakamura T, Watanabe H, Nishikawa H, Ikeno Y, Tanaka J, Ohsawa M, Kikuchi A, Numata T, Kuroda H, Abe M, Ishii T

    Traditional and Kampo medicine　3　(2)　167-169　2016/10

  98. Development and Verification of a Mobile Shelter Assessment System "Rapid Assessment System of Evacuation Center Condition Featuring Gonryo and Miyagi (RASECC-GM)" for Major Disasters Peer-reviewed

    Tadashi Ishii, Masaharu Nakayama, Michiaki Abe, Shin Takayama, Takashi Kamei, Yoshiko Abe, Jun Yamadera, Koichiro Amito, Kazuma Morino

    PREHOSPITAL AND DISASTER MEDICINE　31　(5)　539-546　2016/10

    DOI： 10.1017/S1049023X16000674 　

    ISSN： 1049-023X

    eISSN： 1945-1938

  99. Questionnaire-Based Development of an Educational Program of Traditional Japanese Kampo Medicine Peer-reviewed

    Shin Takayama, Seiichi Ishii, Fumie Takahashi, Natsumi Saito, Ryutaro Arita, Soichiro Kaneko, Masashi Watanabe, Tetsuharu Kamiya, Hidekazu Watanabe, Hitoshi Nishikawa, Yuka Ikeno, Junichi Tanaka, Minoru Ohsawa, Akiko Kikuchi, Takehiro Numata, Hitoshi Kuroda, Michiaki Abe, Takashi Takeda, Nobuo Yaegashi, Tadashi Ishii

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　240　(2)　123-130　2016/10

    DOI： 10.1620/tjem.240.123 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  100. Standard method for ultrasound evaluation of renal arterial lesions Peer-reviewed

    Yoshiki Hirooka, Hiroshi Matsuo, Michiaki Abe, Yoshio Iwashima, Keita Odashiro, Hiroshi Sato, Kei Takase, Toshiko Hirai, Makoto Matsumura, Takashi Miki

    JOURNAL OF MEDICAL ULTRASONICS　43　(1)　145-162　2016/01

    DOI： 10.1007/s10396-015-0651-3 　

    ISSN： 1346-4523

    eISSN： 1613-2254

  101. Prominent hyperplasia of renin-producing juxtaglomerular apparatus after chronic and complete blockade of the renin-angiotensin system in adult IgA nephropathy. Peer-reviewed

    Abe M, Joh K, Ieiri N, Hotta O, Utsunomiya Y, Sato H, Kisu K, Sakumo N, Kiyomoto H, Sato T, Taguma Y, Ito S

    CEN case reports　4　(2)　228-232　2015/11

    DOI： 10.1007/s13730-015-0177-y 　

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    Juxtaglomerular apparatus (JGA) hyperplasia rarely happened in renal biopsy and has been controversial clinically, because synthesis and secretion of renin were susceptible to the effect of clinical condition and medication. Here we present the case of a 39-year-old who got JGA hyperplasia of IgA nephropathy (IgAN) after long-term inhibition of the renin-angiotensin system (RAS) with an angiotensin receptor blocker (ARB), and a direct renin inhibitor (DRI) in combination with a diuretic. He was diagnosed with IgAN in his first renal biopsy, and was treated with supra-maximal dosages of ARB, DRI and a diuretic. In the second biopsy, because of the massive proteinuria and occurrence of steroid-induced diabetes, it was revealed that the area and the number of JGA cells were strikingly increased in observed glomeruli. Immunohistopathologically, the both specimens were stained by human renin antibody. The hyperplastic JG cells contained a large amount of renin granules. Putative renin granules were observed in some interstitial cells adjacent to an afferent arteriole by electron microscopy. The increasing response of renin granules co-localized in prominent JGA hyperplasia should be worried while physicians treat hypertensive patients with potent RAS inhibitors and diuretics even though they have diabetes. This is the first report showing a clinical course of forming prominent JGA hyperplasia directly after a full combination of RAS inhibitors and diuretics in adult IgA nephropathy.

  102. Quantitative Targeted Proteomics of Pancreatic Cancer: Deoxycytidine Kinase Protein Level Correlates to Progression-Free Survival of Patients Receiving Gemcitabine Treatment Peer-reviewed

    Ken Ohmine, Kei Kawaguchi, Sumio Ohtsuki, Fuyuhiko Motoi, Hideo Ohtsuka, Junichi Kamiie, Takaaki Abe, Michiaki Unno, Tetsuya Terasaki

    MOLECULAR PHARMACEUTICS　12　(9)　3282-3291　2015/09

    DOI： 10.1021/acs.molpharmaceut.5b00282 　

    ISSN： 1543-8384

  103. Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals Peer-reviewed

    Masao Nagasaki, Jun Yasuda, Fumiki Katsuoka, Naoki Nariai, Kaname Kojima, Yosuke Kawai, Yumi Yamaguchi-Kabata, Junji Yokozawa, Inaho Danjoh, Sakae Saito, Yukuto Sato, Takahiro Mimori, Kaoru Tsuda, Rumiko Saito, Xiaoqing Pan, Satoshi Nishikawa, Shin Ito, Yoko Kuroki, Osamu Tanabe, Nobuo Fuse, Shinichi Kuriyama, Hideyasu Kiyomoto, Atsushi Hozawa, Naoko Minegishi, James Douglas Engel, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto

    NATURE COMMUNICATIONS　6　(8018)　1-13　2015/08

    DOI： 10.1038/ncomms9018 　

    ISSN： 2041-1723

  104. Post-traumatic stress disorder and depression prevalence and associated risk factors among local disaster relief and reconstruction workers fourteen months after the Great East Japan Earthquake: a cross-sectional study Peer-reviewed

    Atsushi Sakuma, Yoko Takahashi, Ikki Ueda, Hirotoshi Sato, Masahiro Katsura, Mikika Abe, Ayami Nagao, Yuriko Suzuki, Masako Kakizaki, Ichiro Tsuji, Hiroo Matsuoka, Kazunori Matsumoto

    BMC PSYCHIATRY　15　58　2015/03

    DOI： 10.1186/s12888-015-0440-y 　

    ISSN： 1471-244X

  105. Reactive oxygen species as important determinants of medullary flow, sodium excretion, and hypertension Peer-reviewed

    Allen W. Cowley, Michiaki Abe, Takefumi Mori, Paul M. O'Connor, Yusuke Ohsaki, Nadezhda N. Zheleznova

    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY　308　(3)　F179-F197　2015/02

    DOI： 10.1152/ajprenal.00455.2014 　

    ISSN： 1931-857X

    eISSN： 1522-1466

  106. How to choice of the suitable renal replacement therapy? -The impact of home hemodialysis Peer-reviewed

    Abe Michiaki

    Transactions of Japanese Society for Medical and Biological Engineering　52　91　2014/08/17

    Publisher: Japan Soc. of Med. Electronics and Biol. Engineering

    DOI： 10.11239/jsmbe.52.SY-91 　

    ISSN： 1347-443X 1881-4379

  107. 超音波による腎動脈病変の標準的評価法(案) Peer-reviewed

    廣岡 芳樹, 松尾 汎, 阿部 倫明, 岩嶋 義雄, 小田代 敬太, 佐藤 洋, 高瀬 圭, 平井 都始子, 松村 誠, 三木 俊, 日本超音波医学会用語, 診断基準委員会, 腎動脈超音波診断ガイドライン小委員会

    超音波医学　41　(3)　389-404　2014/05

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  108. Plasticity of Renal Erythropoietin-Producing Cells Governs Fibrosis Peer-reviewed

    Tomokazu Souma, Shun Yamazaki, Takashi Moriguchi, Norio Suzuki, Ikuo Hirano, Xiaoqing Pan, Naoko Minegishi, Michiaki Abe, Hideyasu Kiyomoto, Sadayoshi Ito, Masayuki Yamamoto

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　24　(10)　1599-1616　2013/10

    DOI： 10.1681/ASN.2013010030 　

    ISSN： 1046-6673

    eISSN： 1533-3450

  109. A Rare Case among Hypertensive Patients: How Do We Handle Reninomas? Peer-reviewed

    Hiroshi Okuda, Michiaki Abe, Hideyasu Kiyomoto

    INTERNAL MEDICINE　52　(17)　1853-1853　2013

    DOI： 10.2169/internalmedicine.52.0973 　

    ISSN： 0918-2918

  110. Metabolic stress response implicated in diabetic retinopathy: The role of calpain, and the therapeutic impact of calpain inhibitor Peer-reviewed

    Ahmed Y. Shanab, Toru Nakazawa, Morin Ryu, Yuji Tanaka, Noriko Himori, Keiko Taguchi, Masayuki Yasuda, Ryo Watanabe, Jiro Takano, Takaomi Saido, Naoko Minegishi, Toshio Miyata, Toshiaki Abe, Masayuki Yamamoto

    NEUROBIOLOGY OF DISEASE　48　(3)　556-567　2012/12

    DOI： 10.1016/j.nbd.2012.07.025 　

    ISSN： 0969-9961

    eISSN： 1095-953X

  111. Luminal Alkalinization Attenuates Proteinuria-Induced Oxidative Damage in Proximal Tubular Cells Peer-reviewed

    Tomokazu Souma, Michiaki Abe, Takashi Moriguchi, Jun Takai, Noriko Yanagisawa-Miyazawa, Eisuke Shibata, Yasutoshi Akiyama, Takafumi Toyohara, Takehiro Suzuki, Masayuki Tanemoto, Takaaki Abe, Hiroshi Sato, Masayuki Yamamoto, Sadayoshi Ito

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　22　(4)　635-648　2011/04

    DOI： 10.1681/ASN.2009111130 　

    ISSN： 1046-6673

    eISSN： 1533-3450

  112. The HMG-CoA Reductase Inhibitor Pravastatin Stimulates Insulin Secretion through Organic Anion Transporter Polypeptides Peer-reviewed

    Michiaki Abe, Takafumi Toyohara, Akiko Ishii, Takehiro Suzuki, Naoya Noguchi, Yasutoshi Akiyama, Hiromi O. Shiwaku, Rie Nakagomi-Hagihara, Guodong Zheng, Eisuke Shibata, Tomokazu Souma, Tomohiko Shindo, Hirohito Shima, Yoichi Takeuchi, Eikan Mishima, Masayuki Tanemoto, Tetsuya Terasaki, Tohru Onogawa, Michiaki Unno, Sadayoshi Ito, Shin Takasawa, Takaaki Abe

    DRUG METABOLISM AND PHARMACOKINETICS　25　(3)　274-282　2010

    DOI： 10.2133/dmpk.25.274 　

    ISSN： 1347-4367

  113. Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells Peer-reviewed

    Noriko Miyazawa, Michiaki Abe, Tomokazu Souma, Masayuki Tanemoto, Takaaki Abe, Masaaki Nakayama, Sadayoshi Ito

    FREE RADICAL RESEARCH　44　(1)　101-107E1　2010/01

    DOI： 10.3109/10715760903321788 　

    ISSN： 1071-5762

    eISSN： 1029-2470

  114. SLCO4C1 Transporter Eliminates Uremic Toxins and Attenuates Hypertension and Renal Inflammation Peer-reviewed

    Takafumi Toyohara, Takehiro Suzuki, Ryo Morimoto, Yasutoshi Akiyama, Tomokazu Souma, Hiromi O. Shiwaku, Yoichi Takeuchi, Eikan Mishima, Michiaki Abe, Masayuki Tanemoto, Satohiro Masuda, Hiroaki Kawano, Koji Maernura, Masaaki Nakayama, Hiroshi Sato, Tsuyoshi Mikkaichi, Hiroaki Yamaguchi, Shigefumi Fukui, Yoshihiro Fukumoto, Hiroaki Shimokawa, Ken-ichi Inui, Tetsuya Terasaki, Junichi Goto, Sadayoshi Ito, Takanori Hishinuma, Isabelle Rubera, Michel Tauc, Yoshiaki Fujii-Kuriyama, Hikaru Yabuuchi, Yoshinori Moriyama, Tomoyoshi Soga, Takaaki Abe

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　20　(12)　2546-2555　2009/12

    DOI： 10.1681/ASN.2009070696 　

    ISSN： 1046-6673

    eISSN： 1533-3450

  115. Hemodynamic index of atheromatous renal artery stenosis for angioplasty. International-journal Peer-reviewed

    Masayuki Tanemoto, Takehiro Suzuki, Michiaki Abe, Takaaki Abe, Sadayoshi Ito

    Clinical journal of the American Society of Nephrology : CJASN　4　(3)　651-5　2009/03

    DOI： 10.2215/CJN.04400808 　

    ISSN： 1555-9041

    More details Close

    BACKGROUND AND OBJECTIVES: Trans-stenotic pressure gradient across the constriction (PG), a hemodynamic variable of atheromatous renal artery stenosis (ARAS), is a widely used indicator for angioplasty, but its association with the outcome of angioplasty has not been fully investigated. DESIGN, SETTING, PARTICIPANTS & MEASUREMENTS: In 34 hypertensive cases with unilateral ARAS, we evaluated hemodymanic variables of ARAS with reference to the systemic BP reduction after angioplasty as the outcome. RESULTS: In each phase, PG divided by its corresponding prestenotic arterial BP (PG/preBP) had better association with the outcome than PG. The mean phase PG/preBP had the largest area under the curve in the receiver operating characteristic analysis (0.794) with the sensitivity/specificity of 0.957/0.545 for its cut-off >0.15. Although the plasma renin activity, which reflects the perfusion to renal parenchyma, was higher in the angioplasty-efficacious cases than in the angioplasty-inefficacious cases before angioplasty (7.8 +/- 6.6 versus 3.4 +/- 3.8 ng/ml/h, P = 0.049), it was not generally reduced by angioplasty independent of the outcome. CONCLUSIONS: As the index to select ARAS for angioplasty, PG/preBP was better than PG and the mean phase PG/preBP could be the best. However, other factors such as the microvascular kidney disease, which affect the perfusion to renal parenchyma, would influence the outcome.

  116. Physiologic variance of corticotropin affects diagnosis in adrenal vein sampling Peer-reviewed

    Masayuki Tanemoto, Takehiro Suzuki, Michiaki Abe, Takaaki Abe, Sadayoshi Ito

    EUROPEAN JOURNAL OF ENDOCRINOLOGY　160　(3)　459-463　2009/03

    DOI： 10.1530/EJE-08-0840 　

    ISSN： 0804-4643

  117. Strain vessel hypothesis: a viewpoint for linkage of albuminuria and cerebro-cardiovascular risk Peer-reviewed

    Sadayoshi Ito, Tasuku Nagasawa, Michiaki Abe, Takefumi Mori

    HYPERTENSION RESEARCH　32　(2)　115-121　2009/02

    DOI： 10.1038/hr.2008.27 　

    ISSN： 0916-9636

  118. Manipulate expression of the kidney specific organic anion transporter SLCO4C1

    Toyohara Takafumi, Suzuki Takehiro, Akiyama Yasutoshi, Takeuchi Yoichi, Mishima Eikan, Abe Michiaki, Tanemoto Masayuki, Ito Sadayoshi, Abe Takaaki

    Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics　24　56-56　2009

    Publisher: The Japanese Society for the Study of Xenobiotics

    DOI： 10.14896/jssxmeeting.24.0.56.0 　

  119. Angiographic index for angioplasty-treatable atheromatous renal artery stenosis Peer-reviewed

    Masayuki Tanemoto, Michiaki Abe, Akira Uruno, Takaaki Abe, Sadayoshi Ito

    HYPERTENSION RESEARCH　31　(5)　881-885　2008/05

    DOI： 10.1291/hypres.31.881 　

    ISSN： 0916-9636

  120. Immunohistochemistry of a proliferation marker Ki67/MIB1 in adrenocortical carcinomas: Ki67/MIB1 labeling index is a predictor for recurrence of adrenocortical carcinomas. Peer-reviewed

    Ryo Morimoto, Fumitoshi Satoh, Osamu Murakami, Takashi Suzuki, Takaaki Abe, Masayuki Tanemoto, Michiaki Abe, Akira Uruno, Shigeto Ishidoya, Yoichi Arai, Kazuhiro Takahashi, Hironobu Sasano, Sadayoshi Ito

    Endocrine journal　55　(1)　49-55　2008/03

    DOI： 10.1507/endocrj.k07-079 　

    ISSN： 0918-8959

    eISSN： 1348-4540

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    Adrenocortical carcinoma (ACC) is a rare, highly malignant tumor. The aim of the present study is to evaluate the prognostic relevance of a proliferation marker Ki67/MIB1 by immunohistochemistry in 17 cases who underwent resections of the primary tumors and diagnosed to have ACC at Tohoku University Hospital based on the criteria of Weiss during the period from 1976 to 2005. The follow-up periods ranged from 221 days to 10659 days (about 29 years) with the median of 1895 days. The median age at diagnosis was 46 years old, and the mean size of the primary tumors was 7.1 cm with the minimal of 3.5 cm. Ki67/MIB1 labeling index (Ki67/MIB1LI) ranged from 1% to 26%. Kaplan-Meier analysis revealed that patients with Ki67/MIB1LI of 7% or more were associated with significantly shortened disease-free survival (P = 0.0037). The evaluation with Weiss criteria revealed that the median score of Weiss criteria was five, and 13 patients (76.5%) presented positive findings in the criteria of mitotic rate. The survival analysis with Weiss score showed that patients with the scores of 6 or more had both significantly shortened disease-free survival (P = 0.0001) and overall survival (P = 0.0063). The present study has suggested that Ki67/MIB1LI, as well as Weiss score, is a useful predictor for tumor recurrence after resection of the primary tumors in patients with ACC.

  121. Immunohistochemistry of a proliferation marker Ki67/MIB1 in adrenocortical carcinomas: Ki67/MIB1 labeling index is a predictor for recurrence of adrenocortical carcinomas. Peer-reviewed

    Ryo Morimoto, Fumitoshi Satoh, Osamu Murakami, Takashi Suzuki, Takaaki Abe, Masayuki Tanemoto, Michiaki Abe, Akira Uruno, Shigeto Ishidoya, Yoichi Arai, Kazuhiro Takahashi, Hironobu Sasano, Sadayoshi Ito

    Endocrine journal　55　(1)　49-55　2008/03

    DOI： 10.1507/endocrj.K07-079 　

    eISSN： 1348-4540

    More details Close

    Adrenocortical carcinoma (ACC) is a rare, highly malignant tumor. The aim of the present study is to evaluate the prognostic relevance of a proliferation marker Ki67/MIB1 by immunohistochemistry in 17 cases who underwent resections of the primary tumors and diagnosed to have ACC at Tohoku University Hospital based on the criteria of Weiss during the period from 1976 to 2005. The follow-up periods ranged from 221 days to 10659 days (about 29 years) with the median of 1895 days. The median age at diagnosis was 46 years old, and the mean size of the primary tumors was 7.1 cm with the minimal of 3.5 cm. Ki67/MIB1 labeling index (Ki67/MIB1LI) ranged from 1% to 26%. Kaplan-Meier analysis revealed that patients with Ki67/MIB1LI of 7% or more were associated with significantly shortened disease-free survival (P = 0.0037). The evaluation with Weiss criteria revealed that the median score of Weiss criteria was five, and 13 patients (76.5%) presented positive findings in the criteria of mitotic rate. The survival analysis with Weiss score showed that patients with the scores of 6 or more had both significantly shortened disease-free survival (P = 0.0001) and overall survival (P = 0.0063). The present study has suggested that Ki67/MIB1LI, as well as Weiss score, is a useful predictor for tumor recurrence after resection of the primary tumors in patients with ACC.

  122. Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes Peer-reviewed

    Hiroaki Yamaguchi, Minako Kobayashi, Masahiro Okada, Toshiko Takeuchi, Michiaki Unno, Takaaki Abe, Junichi Goto, Takanori Hishinuma, Nariyasu Mano

    CANCER LETTERS　260　(1-2)　163-169　2008/02

    DOI： 10.1016/j.canlet.2007.10.040 　

    ISSN： 0304-3835

  123. Diagnosis of aldosterone producing adenomas Peer-reviewed

    M. Tanemoto, T. Abe, S. Ito

    KIDNEY INTERNATIONAL　73　(3)　362-363　2008/02

    DOI： 10.1038/sj.ki.5002678 　

    ISSN： 0085-2538

  124. [Case of rhabdomyolysis induced by the approved daily dose of a traditional Chinese medicine]. Peer-reviewed

    Takafumi Toyohara, Masayuki Tanemoto, Akira Uruno, Michiaki Abe, Takaaki Abe, Sadayoshi Ito

    Nihon Jinzo Gakkai shi　50　(2)　135-9　2008

    ISSN： 0385-2385

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    We report a case of a 67-year-old woman with hypokalemic rhabdomyolysis induced by pseudohyperaldosteronism. The pseudohyperaldosteronism in this case was caused by the administration of a traditional Chinese medicine, which contained 2.0 g of licorice in the approved daily dose. She started to suffer from hypertension and general fatigue after taking the medication, but continued it for two years until admission after an episode of diarrhea and vomiting. On admission, severe hypokalemia (1.6 mEq/L) and increased serum creatinine kinase (8,778 IU/L) was noted. With the findings of a high transtubular potassium concentration gradient (TTKG) in spite of low plasma renin activity and a low plasma aldosterone concentration, we suspected licorice-induced pseudohyperaldosteronism as the cause of her hypokalemic rhabdomyolysis. The Chinese medicine was terminated, and she received appropriate hydration and potassium replacement therapy as judged by the value of TTKG with the result that her serum potassium and creatinine kinase levels were normalized without any more adverse events. Since it was only a low dose of licorice (2.0 g/day) that induced hypokalemic rhabdomyolysis in this case, serum electrolytes should be examined in all cases under the possible consumption of licorice.

  125. Localization of aldosterone-producing adrenocortical adenomas: Significance of adrenal venous sampling Peer-reviewed

    Fumitoshi Satoh, Takaaki Abe, Masayuki Tanemoto, Masahiro Nakamura, Michiaki Abe, Akira Uruno, Ryo Morimoto, Akihiro Sato, Kei Takase, Shigeto Ishidoya, Yoichi Arai, Takashi Suzuki, Hironobu Sasano, Tadashi Ishibashi, Sadayoshi Ito

    HYPERTENSION RESEARCH　30　(11)　1083-1095　2007/11

    DOI： 10.1291/hypres.30.1083 　

    ISSN： 0916-9636

  126. Methylglyoxal induces oxidative stress production in human aortic endothelial cells Peer-reviewed

    Noriko Miyazawa, Michiaki Abe, Hiroyuki Terawaki, Takaaki Abe, Masaaki Nakayama, Sadayoshi Ito

    HYPERTENSION　50　(4)　E126-E126　2007/10

    ISSN： 0194-911X

  127. Enhanced superoxide production in renal outer medulla of Dahl salt-sensitive rats reduces nitric oxide tubular-vascular cross-talk Peer-reviewed

    Takefumi Mori, Paul M. O&apos;Connor, Michiaki Abe, Allen W. Cowley

    HYPERTENSION　49　(6)　1336-1341　2007/06

    DOI： 10.1161/HYPERTENSIONAHA.106.085811 　

    ISSN： 0194-911X

  128. Mesangial proliferative glomerulonephritis with aldosterone-producing adenoma. Peer-reviewed

    Masayuki Tanemoto, Michiaki Abe, Fumitoshi Satoh, Takaaki Abe, Hiroshi Satoh, Sadayoshi Ito

    Clinical and experimental nephrology　11　(2)　164-167　2007/06

    DOI： 10.1007/s10157-007-0460-0 　

    ISSN： 1342-1751

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    We describe a case of mesangial proliferative glomerulonephritis (MesPGN), the clinical symptoms of which were exacerbated by aldosterone-producing adenoma (APA). A 45-year-old man, who had had a history of hypertension for several years, presented with renal derangement, with serum creatinine at its upper normal limit and with microhematuria and proteinuria. He also presented with hypokalemia, with a plasma aldosterone concentration at its upper normal limit and plasma renin activity at its lower normal limit. After the administration of spironolactone, we resected his left adrenal gland, which had a nodular lesion as well as aldosterone hypersecretion. The treatment normalized his arterial blood pressure and serum potassium concentration. Although his proteinuria disappeared with the reduction in arterial blood pressure, the microhematuria continued. The administration of losartan because of the histological finding of MesPGN reduced the amount of hematuria. A dissociated response of hematuria and proteinuria to antihypertensive treatment indicated that MesPGN was coincidental with APA.

  129. Methlglyoxal induces oxidative stress in aortic endothelial cells. Peer-reviewed

    Noriko Miyazawa, Michiaki Abe, Hiroyuki Terawaki, Keisuke Nakayama, Takafami Toyohara, Eisuke Shibata, Masayuki Tanemoto, Takaaki Abe, Masaaki Nakayama, Sadayoshi Ito

    FASEB JOURNAL　21　(6)　A816-A816　2007/04

    ISSN： 0892-6638

  130. PRAVASTATIN, HMG-COA REDUCTASE INHIBITOR, STIMULATES INSULIN SECRETION THROUGH ORGANIC ANION TRANSPORTER IN THE PANCREAS Peer-reviewed

    Takafumi Toyohara, Takehiro Suzuki, Michiaki Abe, Hiromi Shiwaku, Yasutoshi Akiyama, Eisuke Shibata, Masayuki Tanemoto, Sumio Ohtsuki, Tetsuya Terasaki, Sadayoshi Ito, Takaaki Abe

    DRUG METABOLISM REVIEWS　39　279-279　2007

    ISSN： 0360-2532

  131. Expression of organic cation transporter SLC22A16 in human endometria Peer-reviewed

    Naoko Sato, Kiyoshi Ito, Toru Onogawa, Jun-ichi Akahira, Michiaki Unno, Takaaki Abe, Hitoshi Niikura, Nobuo Yaegashi

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY　26　(1)　53-60　2007/01

    DOI： 10.1097/01.pgp.0000225845.67245.b3 　

    ISSN： 0277-1691

  132. 『腎尿細管におけるNa負荷によるRedox調節』 -高血圧発症・増悪に関わるNaの役割に関する検討— Invited Peer-reviewed

    阿部倫明, 伊藤貞嘉, Allen AW Cowley, J

    血管　(30)　101-108　2007

  133. Therapeutic intervention of morning hypertension by the angiotensin II receptor blocker olmesartan - Clinical implication of the reduction of albuminuria for the prevention of brain and heart disease Peer-reviewed

    Fumitoshi Satoh, Ryo Morimoto, Akira Uruno, Michiaki Abe, Masayuki Tanemoto, Takaaki Abe, Sadayoshi Ito

    JOURNAL OF HYPERTENSION　24　252-253　2006/12

    ISSN： 0263-6352

  134. Beneficial effects of pitavastatin on serum lipids and inflammatory mediators in the treatment of hypertensive, hypercholesterolemic patients Peer-reviewed

    Fumitoshi Satoh, Ryo Morimoto, Akira Uruno, Michiaki Abe, Masayuki Tanemoto, Takaaki Abe, Sadayoshi Ito

    JOURNAL OF HYPERTENSION　24　371-371　2006/12

    ISSN： 0263-6352

  135. Effect of sodium delivery on superoxide and nitric oxide in the medullary thick ascending limb Peer-reviewed

    Michiaki Abe, Paul O&apos;Connor, Mary Kaldunski, Mingyu Liang, Richard J. Roman, Allen W. Cowley

    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY　291　(2)　F350-F357　2006/08

    DOI： 10.1152/ajprenal.00407.2005 　

    ISSN： 1931-857X

  136. Aidosterone-producing adenoma accompanied with renal artery stenosis Peer-reviewed

    Masayuki Tanemoto, Kenji Honkura, Michiaki Abe, Fumitoshi Satoh, Takaaki Abe, Sadayoshi Ito

    JOURNAL OF NEPHROLOGY　19　(4)　540-542　2006/07

    ISSN： 1121-8428

  137. Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3 Peer-reviewed

    H Yamaguchi, M Okada, S Akitaya, H Ohara, T Mikkaichi, H Ishikawa, M Sato, M Matsuura, T Saga, M Unno, T Abe, N Mano, T Hishinuma, J Goto

    JOURNAL OF LIPID RESEARCH　47　(6)　1196-1202　2006/06

    DOI： 10.1194/jlr.M500532-JLR200 　

    ISSN： 0022-2275

  138. Renal artery dissection after angiographic evaluation of lower extremities Peer-reviewed

    M Tanemoto, M Abe, F Satoh, T Abe, S Ito

    HYPERTENSION RESEARCH　28　(10)　853-855　2005/10

    DOI： 10.1291/hypres.28.853 　

    ISSN： 0916-9636

  139. Characterization of the organic cation transporter SLC22A16: A doxorubicin importer Peer-reviewed

    M Okabe, M Unno, H Harigae, M Kaku, Y Okitsu, T Sasaki, T Mizoi, K Shiiba, H Takanaga, T Terasaki, S Matsuno, Sasaki, I, S Ito, T Abe

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　333　(3)　754-762　2005/08

    DOI： 10.1016/j.bbrc.2005.05.174 　

    ISSN： 0006-291X

  140. 重症高血圧におけるアンジオテンシンII受容体拮抗薬とアンジオテンシン変換酵素阻害薬の併用経験 症例報告を中心として

    種本雅之, 阿部高明, 茶木辰治, 鈴木恵綾, 阿部倫明, 佐藤文俊, 伊藤貞嘉

    Therapeutic Research　25　(9)　1883-1889　2004/09

  141. Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney Peer-reviewed

    T Mikkaichi, T Suzuki, T Onogawa, M Tanemoto, H Mizutamari, M Okada, T Chaki, S Masuda, T Tokui, N Eto, M Abe, F Satoh, M Unno, T Hishinuma, K Inui, S Ito, J Goto, T Abe

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　101　(10)　3569-3574　2004/03

    DOI： 10.1073/pnas.0304987101 　

    ISSN： 0027-8424

  142. The Organic Anion Transporter (OATP) Family Peer-reviewed

    Mikkaichi T, Suzuki T, Tanemoto M, Ito S, Abe T

    Drug Metabol. Pharmacokin.　19　(3)　171-179　2004

    DOI： 10.2133/dmpk.19.171 　

    ISSN： 1347-4367

  143. Molecular characterization of human and rat organic anion transporter OATP-D Peer-reviewed

    Hisanobu Adachi, Takehiro Suzuki, Michiaki Abe, Naoki Asano, Hiroya Mizutamari, Masayuki Tanemoto, Toshiyuki Nishio, Tohru Onogawa, Takafumi Toyohara, Satoshi Kasai, Fumitoshi Satoh, Masanori Suzuki, Taro Tokui, Michiaki Unno, Tooru Shimosegawa, Seiki Matsuno, Sadayoshi Ito, Takaaki Abe

    American Journal of Physiology - Renal Physiology　285　(6)　F1188-F1197　2003/12

    ISSN： 0363-6127

  144. Molecular characterization of human and rat organic anion transporter OATP-D Peer-reviewed

    H Adachi, T Suzuki, M Abe, N Asano, H Mizutamari, M Tanemoto, T Nishio, T Onogawa, T Toyohara, S Kasai, F Satoh, M Suzuki, T Tokui, M Unno, T Shimosegawa, S Matsuno, S Ito, T Abe

    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY　285　(6)　F1188-F1197　2003/12

    DOI： 10.1152/ajprenal.00402.2002 　

    ISSN： 1931-857X

  145. Relapse of Graves' disease in a patient with pheochromocytoma Peer-reviewed

    M Abe, K Mori, K Nagai, S Ito

    ENDOCRINE JOURNAL　50　(6)　767-770　2003/12

    DOI： 10.1507/endocrj.50.767 　

    ISSN： 0918-8959

  146. 大動脈における潰瘍の発生頻度の検討 宮古病院における過去2年間の解剖例から

    石田鉄也, 川村修, 阿部倫明

    岩手県立宮古病院医学雑誌　6　15-17　2003/12

  147. Successful treatment of severe hypertension with the combination of angiotensin converting enzyme inhibitor and angiotensin II receptor blocker Peer-reviewed

    M Tanemoto, T Abe, N Obara, M Abe, F Satoh, S Ito

    HYPERTENSION RESEARCH　26　(10)　863-868　2003/10

    DOI： 10.1291/hypres.26.863 　

    ISSN： 0916-9636

  148. Nongenomic vascular action of aldosterone in the glomerular microcirculation Peer-reviewed

    S Arima, K Kohagura, HL Xu, A Sugawara, T Abe, F Satoh, K Takeuchi, S Ito

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　14　(9)　2255-2263　2003/09

    DOI： 10.1097/01.ASN.0000083982.74108.54 　

    ISSN： 1046-6673

  149. Identification and characterization of novel rat and human gonad-specific organic anion transporters Peer-reviewed

    T Suzuki, T Onogawa, N Asano, H Mizutamari, T Mikkaichi, M Tanemoto, M Abe, F Satoh, M Unno, K Nunoki, M Suzuki, T Hishinuma, J Goto, T Shimosegawa, S Matsuno, S Ito, T Abe

    MOLECULAR ENDOCRINOLOGY　17　(7)　1203-1215　2003/07

    DOI： 10.1210/me.2002-0304 　

    ISSN： 0888-8809

  150. Expression of organic anion transporting polypeptide E (OATP-E) in human placenta Peer-reviewed

    K Sato, J Sugawara, T Sato, H Mizutamari, T Suzuki, A Ito, T Mikkaichi, T Onogawa, M Tanemoto, M Unno, T Abe, K Okamura

    PLACENTA　24　(2-3)　144-148　2003/02

    DOI： 10.1053/plac.2002.0907 　

    ISSN： 0143-4004

  151. Thyroid hormone transporters: recent advances Peer-reviewed

    T Abe, T Suzuki, M Unno, T Tokui, S Ito

    TRENDS IN ENDOCRINOLOGY AND METABOLISM　13　(5)　215-220　2002/07

    DOI： 10.1016/S1043-2760(02)00599-4 　

    ISSN： 1043-2760

  152. Biphasic vasodilator action of troglitazone on the renal microcirculation Peer-reviewed

    S Arima, K Kohagura, K Takeuchi, Y Taniyama, A Sugawara, Y Ikeda, M Abe, K Omata, S Ito

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　13　(2)　342-349　2002/02

    ISSN： 1046-6673

  153. Involvement of cytochrome P450 metabolites in the vascular action of angiotensin II on the afferent arterioles Peer-reviewed

    K Kohagura, S Arima, Y Endo, Y Chiba, O Ito, M Abe, K Omata, S Ito

    HYPERTENSION RESEARCH　24　(5)　551-557　2001/09

    DOI： 10.1291/hypres.24.551 　

    ISSN： 0916-9636

  154. Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for acyl-CoA synthetase 4 deficiency Peer-reviewed

    YY Cho, MJ Kang, H Sone, T Suzuki, M Abe, M Igarashi, T Tokunaga, S Ogawa, YA Takei, T Miyazawa, H Sasano, T Fujino, TT Yamamoto

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　284　(4)　993-997　2001/06

    DOI： 10.1006/bbrc.2001.5065 　

    ISSN： 0006-291X

  155. Activation of Reg gene, a gene for insulin-producing beta-cell regeneration: Poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation Peer-reviewed

    T Akiyama, S Takasawa, K Nata, S Kobayashi, M Abe, NJ Shervani, T Ikeda, K Nakagawa, M Unno, S Matsuno, H Okamoto

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　98　(1)　48-53　2001/01

    DOI： 10.1073/pnas.240458597 　

    ISSN： 0027-8424

  156. Mechanisms that control glomerular hemodynamics Peer-reviewed

    S. Arima, K. Kohagura, M. Abe, S. Ito

    Clinical and Experimental Nephrology　5　(2)　55-61　2001

    DOI： 10.1007/s101570170012 　

    ISSN： 1342-1751

  157. Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D-2, leuko-triene C-4, and taurocholate Peer-reviewed

    T Nishio, H Adachi, R Nakagomi, T Tokui, E Sato, M Tanemoto, K Fujiwara, M Okabe, T Onogawa, T Suzuki, D Nakai, K Shiiba, M Suzuki, H Ohtani, Y Kondo, M Unno, S Ito, K Iinuma, K Nunoki, S Matsuno, T Abe

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　275　(3)　831-838　2000/09

    DOI： 10.1006/bbrc.2000.3377 　

    ISSN： 0006-291X

  158. Identification of a novel Reg family gene, Reg III delta, and mapping of all three types of Reg family gene in a 75 kilobase mouse genomic region Peer-reviewed

    M Abe, K Nata, T Akiyama, NJ Shervani, S Kobayashi, T Tomioka-Kumagai, S Ito, S Takasawa, H Okamoto

    GENE　246　(1-2)　111-122　2000/04

    DOI： 10.1016/S0378-1119(00)00059-7 　

    ISSN： 0378-1119

  159. Identification of a receptor for Reg (Regenerating gene) protein, a pancreatic beta-cell regeneration factor Peer-reviewed

    S Kobayashi, T Akiyama, K Nata, M Abe, M Tajima, NJ Shervani, M Unno, S Matsuno, H Sasaki, S Takasawa, H Okamoto

    JOURNAL OF BIOLOGICAL CHEMISTRY　275　(15)　10723-10726　2000/04

    DOI： 10.1074/jbc.275.15.10723 　

    ISSN： 0021-9258

  160. Molecular characterization and functional regulation of a novel rat liver-specific organic anion transporter rlst-1 Peer-reviewed

    M Kakyo, M Unno, T Tokui, R Nakagomi, T Nishio, H Iwasashi, D Nakai, M Seki, M Suzuki, T Naitoh, S Matsuno, H Yawo, T Abe

    GASTROENTEROLOGY　117　(4)　770-775　1999/10

    DOI： 10.1016/S0016-5085(99)70333-1 　

    ISSN： 0016-5085

  161. IL-6によるラット・トロンボキサン受容体遺伝子の発現調節 Peer-reviewed

    谷山 佳弘, 竹内和久, 高橋信行, 菅原 明, 加藤太郎, 阿部倫明, 阿部圭志, 伊藤貞嘉

    血圧　5　(3)　250-254　1998

  162. アンジオテンシン㈼による血管収縮作用の腎内ヘテロジェネイティ

    矢尾板啓, 有馬秀二, 遠藤好美, 阿部倫明, 竹内和久, 伊藤貞嘉

    代謝異常治療研究基金研究業績集　25　74-79　1998

  163. Possible role of P-450 metabolite of arachidonic acid in vasodilator mechanism of angiotensin II type 2 receptor in the isolated microperfused rabbit afferent arteriole Peer-reviewed

    S Arima, Y Endo, H Yaoita, K Omata, S Ogawa, K Tsunoda, M Abe, K Takeuchi, K Abe, S Ito

    JOURNAL OF CLINICAL INVESTIGATION　100　(11)　2816-2823　1997/12

    ISSN： 0021-9738

    eISSN： 1558-8238

  164. Frequent gain of copy number on the long arm of chromosome 20 in herman pancreatic adenocarcinoma Peer-reviewed

    S Fukushige, FM Waldman, M Kimura, T Abe, T Furukawa, M Sunamura, M Kobari, A Horii

    GENES CHROMOSOMES & CANCER　19　(3)　161-169　1997/07

    DOI： 10.1002/(SICI)1098-2264(199707)19:3<161::AID-GCC5>3.0.CO;2-W 　

    ISSN： 1045-2257

  165. Rat kidney thromboxane synthase: cDNA cloning and gene expression regulation in hydronephrotic kidney Peer-reviewed

    E Tsutsumi, K Takeuchi, T Abe, N Takahashi, T Kato, Y Taniyama, Y Ikeda, S Ito, K Abe

    PROSTAGLANDINS　53　(6)　423-431　1997/06

    DOI： 10.1016/S0090-6980(97)00059-2 　

    ISSN： 0090-6980

  166. Association of a mutation in thiazide-sensitive Na-Cl cotransporter with familial Gitelman's syndrome Peer-reviewed

    K Takeuchi, S Kure, T Kato, Y Taniyama, N Takahashi, Y Ikeda, T Abe, K Narisawa, Y Muramatsu, K Abe

    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM　81　(12)　4496-4499　1996/12

    DOI： 10.1210/jc.81.12.4496 　

    ISSN： 0021-972X

    eISSN： 1945-7197

  167. Detailed deletion mapping on chromosome arm 12q in human pancreatic adenocarcinoma: Identification of a I-cM region of common allelic loss Peer-reviewed

    M Kimura, T Abe, M Sunamura, S Matsuno, A Horii

    GENES CHROMOSOMES & CANCER　17　(2)　88-93　1996/10

    DOI： 10.1002/(SICI)1098-2264(199610)17:2<88::AID-GCC3>3.0.CO;2-X 　

    ISSN： 1045-2257

Show all ︎Show first 5

Misc. 256

  1. COVID-19軽症者療養施設医療対応のための検査体制とその有用性

    高山真, 小野理恵, 有田龍太郎, 齊藤奈津美, 鈴木聡子, 只野恭教, 赤石哲也, 田中淳一, 菅野武, 菊地章子, 大澤稔, 小野寺浩, 阿部倫明, 井戸敬介, 稲葉洋平, 中村直毅, 中山雅晴, 石井正

    日本病院総合診療医学会雑誌(Web)　17　(臨増2)　178-178　2021

    Publisher: (一社)日本病院総合診療医学会

    ISSN： 2185-8136

    eISSN： 2758-7878

  2. The relevance based between renal doppler ultrasonography and age, renal function and blood pressure

    阿部倫明, 赤石哲也, 石沢興太, 三木俊, 三木未佳, 船水康陽, 新谷香織, 高山真, 石井正

    超音波医学 Supplement　47　2020

    ISSN： 1881-9311

  3. 経口アルカリ性化剤治療による早朝尿pHと随時尿pHの変動から腎保護効果をどう考えるか

    阿部 倫明, 赤石 哲也, 田中 淳一, 石沢 興太, 高山 真, 小野寺 浩, 石井 正

    日本病院総合診療医学会雑誌　15　(6)　583-583　2019/11

    Publisher: (一社)日本病院総合診療医学会

    ISSN： 2185-8136

  4. 東日本大震災後の被災地体験実習のキャリアに与える長期的な影響に関するアンケート調査

    田中 淳一, 有田 龍太郎, 奥田 拓史, 齊藤 奈津美, 阿部 喜子, 金子 聡一郎, 高山 真, 阿部 倫明, 石井 正

    医学教育　50　(Suppl.)　106-106　2019/07

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  5. 東日本大震災後の被災地体験実習のキャリアに与える長期的な影響に関するアンケート調査

    田中 淳一, 有田 龍太郎, 奥田 拓史, 齊藤 奈津美, 阿部 喜子, 金子 聡一郎, 高山 真, 阿部 倫明, 石井 正

    医学教育　50　(Suppl.)　106-106　2019/07

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  6. 早朝尿pHと随時尿pHの違いに見た経口アルカリ性化剤による腎保護効果

    阿部 倫明, 佐藤 文俊, 佐藤 博, 工藤 正孝, 森本 玲, 中道 崇, 小川 晋, 沼田 健裕, 清元 秀泰, 庄子 睦美, 三木 俊, 赤石 哲也, 石沢 興太, 石井 正, 伊藤 貞嘉

    日本腎臓学会誌　61　(3)　406-406　2019/05

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  7. 血管エコー標準的評価法の作成で何が変わったか? 当院における腎動脈エコーガイドラインの活用 検査法および教育体制を中心に

    船水 康陽, 三木 俊, 三木 未佳, 伊藤 記彦, 阿部 倫明, 高瀬 圭

    超音波検査技術　44　(Suppl.)　S94-S94　2019/04

    Publisher: (一社)日本超音波検査学会

    ISSN： 1881-4506

  8. 登米市立上沼診療所における漢方薬処方状況と傾向について

    齊藤奈津美, 佐々木直英, 沼田健裕, 沼田健裕, 菊地章子, 有田龍太郎, 金子聡一郎, 田中淳一, 阿部倫明, 高山真, 石井正

    日本プライマリ・ケア連合学会学術大会抄録集　10th (Web)　2019

  9. 【慢性腎臓病における心血管障害】CVDの診断と治療 腎動脈狭窄

    阿部 倫明

    腎と透析　86　(1)　107-113　2019/01

    Publisher: (株)東京医学社

    ISSN： 0385-2156

  10. 一般住民における尿中蛋白排泄量に関連するSNPの探索

    奥田 拓史, 牧野 悟士, 田邊 修, 石井 正, 伊藤 貞嘉, 寳澤 篤, 丹野 高三, 佐々木 真理, 田宮 元, 山本 雅之, 阿部 倫明

    日本高血圧学会総会プログラム・抄録集　41回　OE02-05　2018/09

    Publisher: (NPO)日本高血圧学会

  11. 「痛み」をめぐる最新医療情報(後編) PainVisionを用いた評価をどのように治療につなげているか

    三木 俊, 阿部 倫明

    精神看護　21　(3)　282-287　2018/05

    Publisher: (株)医学書院

    ISSN： 1343-2761

  12. 【疾患・病態を理解する-尿沈渣レファレンスブック】全身性疾患 脱水

    阿部 倫明

    臨床検査　62　(4)　541-543　2018/04

    Publisher: (株)医学書院

    ISSN： 0485-1420

  13. 【疾患・病態を理解する-尿沈渣レファレンスブック】全身性疾患 発熱

    阿部 倫明

    臨床検査　62　(4)　544-546　2018/04

    Publisher: (株)医学書院

    ISSN： 0485-1420

  14. 血管エコーのレポート作成のポイント 腎動脈エコーのレポート作成のポイント

    船水 康陽, 三木 俊, 三木 未佳, 伊藤 記彦, 後藤 均, 阿部 倫明

    超音波医学　45　(Suppl.)　S442-S442　2018/04

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

  15. 漢方は災害時に役立つか?

    高山 真, 沼田 健裕, 菊地 章子, 齊藤 奈津美, 有田 龍太郎, 田中 淳一, 黒田 仁, 阿部 倫明, 石井 正

    日本内科学会雑誌　107　(Suppl.)　258-258　2018/02

    Publisher: (一社)日本内科学会

    ISSN： 0021-5384

    eISSN： 1883-2083

  16. 東北大学における地域総合診療医育成寄附講座の設置

    石井正, 小野寺浩, 阿部倫明, 高山真, 金子聡一郎, 田中淳一, 黒田仁, 菊地章子, 有田龍太郎, 齊藤奈津美, 奥田拓史

    日本プライマリ・ケア連合学会学術大会抄録集　9th　402　2018

  17. 東北大学病院総合診療科を受診し漢方治療を行った症例の特徴と経過

    高山真, 野崎裕之, 阿部倫明, 鈴木聡子, 奥田拓史, 有田龍太郎, 齊藤奈津美, 田中淳一, 沼田健裕, 菊地章子, 大澤稔, 黒田仁, 阿部倫明, 奈良正之, 石井正

    日本プライマリ・ケア連合学会学術大会抄録集　9th　307　2018

  18. 痛み」をめぐる最新医療情報（後編）；PainVisionを用いた評価をどのように治療に繋げているか Invited

    三木 俊, 阿部倫明

    精神看護　21　282-287　2018

    DOI： 10.11477/mf.1689200484 　

  19. 全身疾患，発熱 Invited

    阿部 倫明

    臨床検査 4月増刊号　62　544-546　2018

    DOI： 10.11477/mf.1542201595 　

  20. 全身疾患，脱水 Invited

    阿部 倫明

    臨床検査 4月増刊号　62　541-543　2018

    DOI： 10.11477/mf.1542201594 　

  21. 東北大学病院総合診療外来における簡易心理検査の有用性と関連要因の検討

    野崎 裕之, 中川 高, 阿部 倫明, 八木橋 真央, 甲賀 ひとみ, 吉村 直仁, 有田 龍太郎, 齊藤 奈津美, 田中 淳一, 沼田 健裕, 菅野 武, 鈴木 聡子, 大澤 稔, 菊池 章子, 黒田 仁, 高山 真, 奈良 正之, 富田 博秋, 石井 正

    総合病院精神医学　29　(Suppl.)　S-203　2017/11

    Publisher: (一社)日本総合病院精神医学会

    ISSN： 0915-5872

  22. 第39回日本高血圧学会総会における『血圧診療に関わる血管診断検査セミナー』の報告

    阿部 倫明, 三木 俊, 松尾 汎, 三木 未佳, 船水 康陽, 濱口 浩敏, 工藤 正孝, 伊藤 貞嘉

    日本高血圧学会総会プログラム・抄録集　40回　402-402　2017/10

    Publisher: (NPO)日本高血圧学会

  23. 気仙沼市立病院における震災前後の透析導入患者の推移について

    阿部 倫明, 高山 真

    日本医療・病院管理学会誌　54　(Suppl.)　124-124　2017/09

    Publisher: (一社)日本医療・病院管理学会

    ISSN： 1882-594X

    eISSN： 2185-422X

  24. 東北大学医学部医学科1年次の東日本大震災被災地見学実習の経過報告 宮城コースと浪江コースとの比較

    阿部 倫明, 田中 淳一, 菊地 章子, 沼田 健裕, 黒田 仁, 高山 真, 石井 誠一, 加賀谷 豊, 石井 正

    医学教育　48　(Suppl.)　123-123　2017/08

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  25. 地域医療研修はプロフェッショナリズムの醸成にどのように寄与するか?

    田中 淳一, 沼田 健裕, 黒田 仁, 阿部 倫明, 高山 真, 石井 正

    医学教育　48　(Suppl.)　174-174　2017/08

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  26. 東北大学『コンダクター型総合診療医』養成プログラムによる総合診療教育の実践

    黒田 仁, 金子 聡一郎, 田中 淳一, 沼田 健裕, 高山 真, 阿部 倫明, 石井 正

    医学教育　48　(Suppl.)　241-241　2017/08

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  27. 気仙沼市立病院における震災前後の新規透析患者の推移

    阿部 倫明, 折笠 一彦, 佐藤 琢磨, 横田 憲一, 大友 浩志, 芹澤 玄, 佐藤 美智代, 尾形 百合, 及川 明子, 加藤 維, 小山 咲子, 清元 秀泰, 宮崎 真理子, 伊藤 貞嘉, 安海 清

    日本透析医学会雑誌　50　(Suppl.1)　817-817　2017/05

    Publisher: (一社)日本透析医学会

    ISSN： 1340-3451

  28. 経口アルカリ性化剤により薬物的血液浄化される尿毒症物質の検討

    阿部 倫明, 三枝 大輔, 小柴 生造, 鈴木 洋一, 田邉 修, 安田 純, 佐藤 文俊, 工藤 正孝, 佐藤 博, 森本 玲, 中道 崇, 小川 晋, 清元 秀泰, 三木 俊, 高山 真, 宮崎 真理子, 石井 正, 伊藤 貞嘉

    日本腎臓学会誌　59　(3)　234-234　2017/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  29. ステロイド依存性・頻回再発型ネフローゼ症候群に対するリツキシマブ治療後のステロイド離脱症候群の検討

    熊谷 直憲, 内田 奈生, 工藤 宏紀, 松木 琢磨, 木越 隆晶, 高橋 俊成, 阿部 倫明

    日本腎臓学会誌　59　(3)　370-370　2017/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  30. 東北大学病院総合診療外来新患におけるうつ度および認知度の実態調査

    阿部倫明, 野崎裕之, 中川高, 八木橋真央, 有田龍太郎, 齊藤奈津美, 田中淳一, 沼田健裕, 菅野武, 宇佐美修, 大澤稔, 黒田仁, 高山真, 奈良正之, 富田博秋, 石井正

    日本プライマリ・ケア連合学会学術大会抄録集　8th　2017

  31. 『コンダクター型総合診療医』養成の取り組み

    黒田仁, 金子聡一郎, 金子聡一郎, 中川高, 田中淳一, 沼田健裕, 沼田健裕, 高山真, 高山真, 阿部倫明, 石井正, 石井正

    日本プライマリ・ケア連合学会学術大会抄録集　8th　2017

  32. 医学生による北日本合同東洋医学研究会の発足とその活動報告

    岡田 将平, 小俣 文弥, 富樫 尭史, 奥田 貴久, 宮本 哲慎, 大須賀 美帆, 田中 康平, 石山 真美, 相磯 愛聖, 安井 廣迪, 八重樫 稔, 久保 かほり, 金子 聡一郎, 神谷 哲治, 齊藤 奈津美, 有田 龍太郎, 渡邉 秀和, 西川 仁, 池野 由佳, 田中 淳一, 大澤 稔, 菊地 章子, 沼田 健裕, 黒田 仁, 阿部 倫明, 高山 真, 石井 正

    日本東洋医学雑誌　68　(1)　72-78　2017/01

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  33. 【動脈硬化の臨床評価指標】腎動脈エコー

    阿部 倫明

    動脈硬化予防　15　(4)　26-33　2016/12

    Publisher: (株)メジカルビュー社

    ISSN： 1347-7056

  34. 酸塩基平衡と生活習慣病

    富野 康日己, 原 茂子, 丸中 良典, 阿部 倫明, 鶴岡 秀一

    腎・高血圧の最新治療　5　(4)　193-203　2016/10

    Publisher: (有)フジメディカル出版

    ISSN： 2187-0004

  35. 高血圧患者における腎動脈エコーによる腎内血流評価の7年間の推移について

    菅原 香織, 阿部 倫明, 三木 俊, 庄子 睦美, 鎌田 真希, 三木 未佳, 齊藤 奈津美, 有田 龍太郎, 沼田 健裕, 田中 淳一, 菊地 章子, 黒田 仁, 高山 真, 菅原 明, 石井 正

    日本高血圧学会総会プログラム・抄録集　39回　321-321　2016/09

    Publisher: (NPO)日本高血圧学会

  36. 東北の2大学病院、2臨床研修指定病院における初期研修医の漢方教育に対する意向調査

    高山 真, 小林 誠一, 石橋 悟, 齊藤 奈津美, 沼田 健裕, 菊地 章子, 石川 敬一, 大澤 稔, 有田 龍太郎, 田中 淳一, 黒田 仁, 阿部 倫明, 田畑 雅央, 佐藤 慎哉, 石井 正

    医学教育　47　(Suppl.)　135-135　2016/07

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  37. 初期臨床研修での地域医療研修に対する基幹型臨床研修病院と協力型研修施設の認識の違い

    田中 淳一, 沼田 健裕, 黒田 仁, 阿部 倫明, 高山 真, 石井 正

    医学教育　47　(Suppl.)　184-184　2016/07

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  38. Intersectin 1とIntersectin 2は糸球体上皮細胞においてIgGに反応する特異的分子である

    熊谷 直憲, 工藤 宏紀, 城 謙輔, 阿部 倫明, 松木 琢磨, 田中 完, 佐藤 博, 呉 繁夫

    日本小児腎臓病学会雑誌　29　(1Suppl.)　172-172　2016/06

    Publisher: (一社)日本小児腎臓病学会

    ISSN： 0915-2245

    eISSN： 1881-3933

  39. Passive Heymann腎炎でIntersectin 1とIntersectin 2はIgGに反応する特異的分子である

    工藤 宏紀, 熊谷 直憲, 阿部 倫明, 田中 完, 呉 繁夫

    日本小児腎臓病学会雑誌　29　(1Suppl.)　173-173　2016/06

    Publisher: (一社)日本小児腎臓病学会

    ISSN： 0915-2245

  40. 知っていると便利な漢方薬、安全に効果的に使うには?

    高山 真, 齊藤 奈津美, 有田 龍太郎, 沼田 健裕, 菊地 章子, 大澤 稔, 池野 由佳, 西川 仁, 渡邉 秀和, 田中 淳一, 黒田 仁, 阿部 倫明, 石井 正

    日本小児救急医学会雑誌　15　(2)　154-154　2016/06

    Publisher: (一社)日本小児救急医学会

    ISSN： 1346-8162

  41. Passive Heymann腎炎においてIntersectin 1とIntersectin 2はIgGに反応する特異的分子である

    工藤 宏紀, 熊谷 直憲, 阿部 倫明, 内田 奈生, 松木 琢磨

    日本腎臓学会誌　58　(3)　278-278　2016/05

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  42. Intersectin 1とIntersectin 2は糸球体係締においてIgGに反応する特異的分子である

    熊谷 直憲, 工藤 宏紀, 城 謙輔, 阿部 倫明, 内田 奈生, 松木 琢磨, 田中 完, 佐藤 博

    日本腎臓学会誌　58　(3)　323-323　2016/05

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  43. 医学教育における漢方 東洋医学を次世代にどのように伝えるか 医学生の授業における問題解決過程を学会発表・論文作成まで展開させる漢方の学術的支援

    高山 真, 沼田 健裕, 金子 聡一郎, 神谷 哲治, 田中 淳一, 池野 由佳, 西川 仁, 齊藤 奈津美, 菊地 章子, 大澤 稔, 有田 龍太郎, 黒田 仁, 松向寺 孝臣, 阿部 倫明, 石井 正

    日本東洋医学雑誌　67　(別冊)　182-182　2016/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  44. 血管エコー検査を用いた血管機能不全の評価 腎動脈超音波診断ガイドラインと腎内血流からみた腎機能的評価

    阿部 倫明

    超音波医学　43　(Suppl.)　S460-S460　2016/04

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

  45. 臨床を想定した漢方薬処方のシミュレーション教育

    齊藤 奈津美, 高山 真, 沼田 健裕, 菊地 章子, 田中 淳一, 黒田 仁, 阿部 倫明, 石井 正

    日本内科学会雑誌　105　(Suppl.)　275-275　2016/02

    Publisher: (一社)日本内科学会

    ISSN： 0021-5384

    eISSN： 1883-2083

  46. 自然消退した再発子宮体癌の一例

    石井正, 阿部倫明, 高山真, 黒田仁, 松向寺孝臣, 田中淳一, 沼田健裕, 阿部喜子

    日本プライマリ・ケア連合学会学術大会抄録集　7th　2016

  47. 鍼灸をおもな題材とした統合医療セミナーの取り組み

    沼田健裕, 沼田健裕, 金子聡一郎, 金子聡一郎, 神谷哲治, 神谷哲治, 高山真, 高山真, 田中淳一, 池野由佳, 池野由佳, 西川仁, 西川仁, 齊藤奈津美, 齊藤奈津美, 菊地章子, 菊地章子, 阿部倫明, 黒田仁, 松向寺孝臣, 石井正, 石井正

    日本プライマリ・ケア連合学会学術大会抄録集　7th　274　2016

  48. 初期研修医の漢方教育に対する意識調査,東北大学病院と石巻赤十字病院の比較

    高山真, 小林誠一, 石橋悟, 齊藤奈津美, 沼田健裕, 菊地章子, 田中淳一, 黒田仁, 田畑雅央, 阿部倫明, 石井正

    日本プライマリ・ケア連合学会学術大会抄録集　7th　336　2016

  49. 座談会：酸塩基平衡と生活習慣病 Invited

    富野 康日己, 原 茂子, 丸中良典, 阿部倫明, 鶴岡秀一

    腎・高血圧の最新治療　5　(4)　193-203　2016

    Publisher: フジメディカル出版

    ISSN： 2187-0004

  50. 腎交感神経除神経術の課題と将来性

    森本 聡, 阿部 倫明

    日本医事新報　(4758)　62-63　2015/07

    Publisher: (株)日本医事新報社

    ISSN： 0385-9215

  51. 大学病院における初期研修医の漢方医学教育に対する意識調査

    高山 真, 田畑 雅央, 小林 誠一, 石橋 悟, 沼田 健裕, 池野 由佳, 齊藤 奈津美, 菊地 章子, 田中 淳一, 松向寺 孝臣, 黒田 仁, 阿部 倫明, 金村 政輝, 加賀谷 豊, 石井 正

    医学教育　46　(Suppl.)　178-178　2015/07

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  52. 腹診シミュレータを用いた漢方医学教育の試み

    富樫 尭史, 高山 真, 沼田 健裕, 池野 由佳, 金子 聡一郎, 神谷 哲治, 齊藤 奈津美, 菊地 章子, 田中 淳一, 松向寺 孝臣, 黒田 仁, 阿部 倫明, 加賀谷 豊, 石井 正, 張替 秀郎

    医学教育　46　(Suppl.)　242-242　2015/07

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  53. 補剤系漢方薬や抗うつ剤が奏効せず抗炎症系漢方薬が奏効した慢性疲労症候群の2症例

    沼田 健裕, 高山 真, 池野 由佳, 菊地 章子, 金子 聡一郎, 神谷 哲治, 齊藤 奈津美, 神 久和, 金村 政輝, 阿部 倫明, 松向寺 孝臣, 黒田 仁, 田中 淳一, 石井 正

    日本疲労学会誌　11　(1)　61-61　2015/05

    Publisher: 日本疲労学会

  54. 片側腎動脈狭窄患者におけるPTRAと薬物療法の選択

    阿部 倫明, 向山 政志

    日本医事新報　(4752)　53-55　2015/05

    Publisher: (株)日本医事新報社

    ISSN： 0385-9215

  55. 補剤系漢方薬や抗うつ剤が奏効せず抗炎症系漢方薬が奏効した慢性疲労症候群の2症例

    沼田 健裕, 高山 真, 池野 由佳, 菊地 章子, 金子 聡一郎, 神谷 哲治, 齊藤 奈津美, 神 久和, 金村 政輝, 阿部 倫明, 松向寺 孝臣, 黒田 仁, 田中 淳一, 石井 正

    日本疲労学会誌　11　(1)　61-61　2015/05

    Publisher: 日本疲労学会

  56. 補剤系漢方薬や抗うつ剤が奏効せず抗炎症系漢方薬が奏効した慢性疲労症候群の2症例

    沼田 健裕, 高山 真, 池野 由佳, 菊地 章子, 金子 聡一郎, 神谷 哲治, 齊藤 奈津美, 神 久和, 金村 政輝, 阿部 倫明, 松向寺 孝臣, 黒田 仁, 田中 淳一, 石井 正

    日本疲労学会誌　11　(1)　99-99　2015/05

    Publisher: 日本疲労学会

  57. 超音波による腎動脈病変の標準的評価法

    廣岡 芳樹, 松尾 汎, 阿部 倫明, 岩嶋 義雄, 小田代 敬太, 佐藤 洋, 高瀬 圭, 平井 都始子, 松村 誠, 三木 俊, 日本超音波医学会用語, 診断基準委員会, 腎動脈超音波診断ガイドライン小委員会

    超音波医学　42　(2)　185-200　2015/03

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  58. 円皮鍼を用いた高齢者の誤嚥性肺炎予防に関する研究

    菊地 章子, 関 隆志, 高山 真, 沼田 健裕, 田中 淳一, 黒田 仁, 松向寺 孝臣, 金村 政輝, 阿部 倫明, 石井 正

    日本内科学会雑誌　104　(Suppl.)　169-169　2015/02

    Publisher: (一社)日本内科学会

    ISSN： 0021-5384

    eISSN： 1883-2083

  59. 漢方薬の血圧、脈拍、眼底血流に対する影響の検討

    高山 真, 沼田 健裕, 志賀 由己浩, 田中 淳一, 黒田 仁, 松向寺 孝臣, 阿部 倫明, 金村 政輝, 中澤 徹, 石井 正

    日本内科学会雑誌　104　(Suppl.)　286-286　2015/02

    Publisher: (一社)日本内科学会

    ISSN： 0021-5384

    eISSN： 1883-2083

  60. 全身痛を主訴とした皮膚所見を伴わないSAPHO症候群の1例

    田中淳一, 金村政輝, 沼田健裕, 沼田健裕, 松向寺孝臣, 黒田仁, 高山真, 高山真, 阿部倫明, 石井正

    日本プライマリ・ケア連合学会学術大会抄録集　6th　2015

  61. 東北地方で総合診療医を増やすための東北大学の取り組み~「学生・研修医のための総合診療医セミナーin東北」~

    田中淳一, 沼田健裕, 沼田健裕, 松向寺孝臣, 黒田仁, 阿部倫明, 金村政輝, 高山真, 高山真, 高山真, 石井正

    日本プライマリ・ケア連合学会学術大会抄録集　6th　2015

  62. Pro⇄Pro内科：腎臓 腎交感神経除神経術の課題と将来性 Invited

    阿部 倫明

    日本医事新報　4758　62　2015

  63. Pro⇄Pro内科：腎臓 片側腎動脈狭窄症患者におけるPTRAと薬物療法の選択 Invited

    阿部 倫明

    日本医事新報　4752　53-55　2015

  64. 【高血圧をめぐる最新の話題】基礎 血圧調節機序(圧-利尿曲線を含む)

    阿部 倫明

    最新医学　69　(11月増刊)　2230-2239　2014/11

    Publisher: (株)最新医学社

    ISSN： 0370-8241

  65. 高血圧の成因としての重要性は?腎vsSNS 腎の立場から 腎臓に特異的な生理学的血圧調節機構について

    阿部 倫明

    日本高血圧学会総会プログラム・抄録集　37回　302-302　2014/10

    Publisher: (NPO)日本高血圧学会

  66. 被災地健康調査における家庭血圧計診断に基づく高血圧症の実態

    清元 秀泰, 寳澤 篤, 田中 由香利, 奥田 拓史, 菅原 準一, 坪井 明人, 布施 昇男, 栗山 進一, 瀧 靖之, 辻 一郎, 阿部 倫明, 高井 貴子, 八重樫 伸生, 山本 雅之, 伊藤 貞嘉

    日本高血圧学会総会プログラム・抄録集　37回　442-442　2014/10

    Publisher: (NPO)日本高血圧学会

  67. 医学科1年次を対象にした被災地体験実習の試み

    田中 淳一, 金村 政輝, 高山 真, 阿部 倫明, 奈良 正之, 石井 正

    医学教育　45　(Suppl.)　111-111　2014/07

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  68. 脳幹部外科的血管除圧により降圧良好となった若年性難治性高血圧症の一例

    奥田 拓史, 阿部 倫明, 伊藤 大亮, 小林 暢子, 遠藤 俊毅, 萩田 庄吾, 伊藤 貞嘉, 清元 秀泰

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　3回　130-130　2014/05

    Publisher: (NPO)日本高血圧学会

  69. 血管エコーガイドラインを検証する 腎動脈エコーの意義と重要性について

    阿部 倫明

    超音波医学　41　(Suppl.)　S397-S397　2014/04

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

  70. 在宅医療・遠隔医療の未来 東日本大震災被災地における地域医療支援の現況と今後の遠隔医療の重要性

    清元 秀泰, 奥田 拓史, 伊藤 大亮, 阿部 倫明, 石井 正, 鈴木 洋一, 川目 裕, 菅原 準一, 瀧 靖之, 中谷 純, 井戸端 永遠, 八重樫 伸生, 山本 雅之

    医工学治療　26　(Suppl.)　76-76　2014/03

    Publisher: (NPO)日本医工学治療学会

    ISSN： 1344-1221

  71. 【根拠からスッキリ!利尿薬の選び方・使い方】(第1章)利尿薬の使い方で困るこんな場面 救急・ICUでの利尿薬の使い方 こんなときどうする?

    奥田 拓史, 阿部 倫明, 清元 秀泰

    レジデントノート　15　(16)　2932-2939　2014/02

    Publisher: (株)羊土社

    ISSN： 1344-6746

  72. 長期的運動は慢性心不全モデルラットの心・腎一酸化窒素合成酵素を増強させる

    伊藤大亮, 伊藤修, 森信芳, 須田千尋, 羽尾清貴, 曹鵬宇, 阿部倫明, 阿部倫明, 清元秀泰, 清元秀泰, 石井正, 石井正, 上月正博

    日本NO学会学術集会プログラム抄録集　14th　2014

  73. 血圧調節機序（圧-利尿曲線を含む），特集：高血圧をめぐる最新の話題 Invited

    阿部 倫明

    最新医学　69　2230-2239　2014

  74. 超音波による腎動脈病変の標準的評価法［日本超音波医学会編］ Peer-reviewed

    松尾 汎, 阿部 倫明, 岩嶋 義雄, 小田代敬太, 佐藤 洋, 高瀬 圭, 平井都始子, 松村 誠, 三木 俊

    超音波医学　41　(3)　389-404　2014

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  75. 【ネフローゼ症候群 診療の新たな潮流】ネフローゼ症候群の治療 腎保護作用の観点からみた薬物療法 レニン-アンジオテンシン系阻害薬,スタチン,抗血小板療法の位置付け

    奥田 拓史, 阿部 倫明, 清元 秀泰

    内科　112　(4)　751-754　2013/10

    Publisher: (株)南江堂

    ISSN： 0022-1961

  76. 【解剖がわかれば走査がわかる 決定版 超音波検査テクニックマスター 腹部・下肢編】(第3章)症例編 線維筋性異形成による腎血管性高血圧症

    阿部 倫明, 清元 秀泰

    Vascular Lab　10　(増刊)　180-185　2013/10

    Publisher: (株)メディカ出版

    ISSN： 1349-4023

  77. 心血管と腎の超音波診断 腎動脈エコー検査の標準化にむけて

    阿部 倫明

    日本高血圧学会総会プログラム・抄録集　36回　232-232　2013/10

    Publisher: (NPO)日本高血圧学会

  78. シスタチンCとCKD

    柳澤 紀子, 阿部 倫明, 清元 秀泰

    呼吸と循環　61　(9)　854-860　2013/09

    Publisher: (株)医学書院

    ISSN： 0452-3458

    More details Close

    シスタチンC(Cys C)は、アミノ酸120残基から構成される分子量約13kDaの塩基性低分子蛋白質で、生理機能の面からはシスタチンプロテアーゼ阻害作用を持つファミリーに分類され、ハウスキーピング作用遺伝子としてコードされている。血中Cys C値は疾患による濃度変化が極めて少なく糸球体濾過率(GFR)を適切に反映するサロゲートマーカーとなりうる。まず腎機能評価に用いるGFR測定について述べ、次にCys Cと血清クレアチニンの比較を中心に、慢性腎臓病診療時の腎機能評価におけるCys Cの有用性とその限界について述べた。

  79. 宮城県美里町における肥満症の現状

    岡村 将史, 坂本 拓矢, 奈古 一宏, 千田 美穂, 玉手 英一, 阿部 倫明, 清元 秀康, 小川 晋, 伊藤 貞嘉

    肥満研究　19　(Suppl.)　196-196　2013/09

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  80. 導入期の血液透析の原理と処方の基本

    清元 秀泰, 奥田 拓史, 阿部 倫明

    日本腎臓学会誌　55　(6)　1033-1033　2013/08

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  81. 宮城県内の病院・診療所へのアンケート解析結果、ならびその結果に基づく地域病院の実態を踏まえた東北大学支援活動の報告

    田中 淳一, 金村 政輝, 高山 真, 阿部 倫明, 奈良 正之, 石井 正

    日本医療・病院管理学会誌　50　(Suppl.)　213-213　2013/08

    Publisher: (一社)日本医療・病院管理学会

    ISSN： 1882-594X

    eISSN： 2185-422X

  82. ToMMoクリニカルフェローによる循環型地域支援の報告(第一期、第二期)

    阿部 倫明, 田中 淳一, 高山 真, 金村 政輝, 奈良 正之, 目時 弘仁, 関口 敦, 児玉 栄一, 坪井 明人, 瀧 靖之, 菅原 準一, 石井 正, 清元 秀泰, 八重樫 伸生

    日本医療・病院管理学会誌　50　(Suppl.)　272-272　2013/08

    Publisher: (一社)日本医療・病院管理学会

    ISSN： 1882-594X

    eISSN： 2185-422X

  83. 【血液透析患者の最適管理をめざして〜一般外来での対応】血液透析患者の血圧管理

    柳澤 紀子, 阿部 倫明, 清元 秀泰

    診断と治療　101　(7)　997-1001　2013/07

    Publisher: (株)診断と治療社

    ISSN： 0370-999X

  84. 腎線維化を規定する腎エリスロポイエチン産生細胞の形質転換とその可逆性

    相馬 友和, 山崎 瞬, 鈴木 教郎, 森口 尚, 阿部 倫明, 清元 秀泰, 伊藤 貞嘉, 山本 雅之

    日本腎臓学会誌　55　(3)　345-345　2013/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  85. 【基礎から臨床応用までの秘伝の技術を大公開!血管のすべてを学ぶ ブラッシュアップ特集 よくわかる よく伝わる 部位別血管エコー検査レポート集】右腎動脈狭窄症(動脈硬化性)

    阿部 倫明, 三木 俊, 三木 未佳

    Vascular Lab　10　(1)　75-81　2013/03

    Publisher: (株)メディカ出版

    ISSN： 1349-4023

  86. 【基礎から臨床応用までの秘伝の技術を大公開!血管のすべてを学ぶ ブラッシュアップ特集 よくわかる よく伝わる 部位別血管エコー検査レポート集】右腎動脈狭窄症(線維筋性異形成)

    阿部 倫明, 三木 俊, 三木 未佳

    Vascular Lab　10　(1)　82-87　2013/03

    Publisher: (株)メディカ出版

    ISSN： 1349-4023

  87. 右腎動脈狭窄症（繊維筋性異形成） Invited

    阿部倫明, 三木 俊, 三木未佳

    10　82-87　2013

  88. 右腎動脈狭窄症（動脈硬化性） Invited

    阿部倫明, 三木 俊, 三木未佳

    Vascular Lab　10　75-81　2013

  89. 【連携して診る腎疾患-タイムリーな紹介から患者マネジメントまで】腎機能を悪化させないために行うべき治療とは 血液浄化療法の選択について,どう説明するか

    阿部 倫明, 清元 秀泰

    Medicina　49　(12)　1938-1943　2012/11

    Publisher: (株)医学書院

    ISSN： 0025-7699

  90. 膜性腎症の経過中に卵巣嚢腫を合併しネフローゼ症候群の再発を認めた1例

    中山 恵輔, 永井 智之, 小泉 賢治, 山本 多恵, 村田 弥栄子, 阿部 倫明, 佐藤 博, 伊藤 貞嘉

    日本腎臓学会誌　54　(6)　744-744　2012/08

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  91. 「機能診断」としての血管エコーを活かす 他の診断法との比較から 「機能診断」としての血管エコーを活かす 腎動脈エコーによる慢性腎臓病の診断と評価

    阿部 倫明

    超音波医学　39　(Suppl.)　S222-S222　2012/04

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

  92. 慢性腎臓病の病気分類からみた超音波ドプラ検査による大動脈・腎内血流評価について

    阿部 倫明, 小泉 賢治, 山本 多恵, 井上 隆輔, 清元 秀泰, 宮崎 真理子, 森 建文, 佐藤 博, 伊藤 貞嘉

    超音波医学　39　(Suppl.)　S399-S399　2012/04

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

  93. 話し合う腎臓 ネフロンセグメント間あるいは周辺の細胞とのクロストーク 糸球体/尿細管クロストーク 蛋白尿がつなぐ糸球体と尿細管障害

    阿部 倫明

    日本腎臓学会誌　54　(3)　197-197　2012/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  94. 慢性腎臓病の病気分類からみた腎内血流・血管抵抗の評価について

    阿部 倫明, 小泉 賢治, 山本 多恵, 村田 弥栄子, 中山 恵輔, 清元 秀泰, 三木 未佳, 宮崎 真理子, 佐藤 博, 伊藤 貞嘉

    日本内科学会雑誌　101　(Suppl.)　191-191　2012/02

    Publisher: (一社)日本内科学会

    ISSN： 0021-5384

  95. 1．動脈硬化症腎動脈狭窄症と腎機能障害の患者におけるステント留置療法 Invited

    阿部倫明, 伊藤貞嘉

    Thrombosis and circulation　19　(3)　639-642　2012

  96. 血液浄化法の選択について，どう説明するか Invited

    阿部倫明, 清元秀泰

    Midicina　49　1938-1943　2012

  97. 蛋白尿による近位尿細管細胞酸化ストレス蓄積における腎内酸性環境の役割

    相馬 友和, 阿部 倫明, 森口 尚, 阿部 高明, 山本 雅之, 伊藤 貞嘉

    血管　34　(4)　167-171　2011/12

    Publisher: 日本心脈管作動物質学会

    ISSN： 0911-4637

  98. The Reduction of Prorenin Levels by Diet and Exercise Therapies Using Telemedicine Ameliorates Insulin Resistance in Patients With Metabolic Syndrome

    Hideyasu Kiyomoto, Atsuhiro Ichihara, Michiaki Abe, Takefumi Mori, Akira Nishiyama, Sadayoshi Ito

    HYPERTENSION　58　(5)　E73-E73　2011/11

    ISSN： 0194-911X

  99. トリアムテレンが著効し、ABPM測定にてdipper型に移行した高齢者難治性高血圧症の一例

    清元 加代, 清元 秀泰, 北村 健一郎, 阿部 倫明, 江尻 一成, 森 建文, 佐藤 博, 伊藤 貞嘉

    日本高血圧学会総会プログラム・抄録集　34回　358-358　2011/10

    Publisher: (NPO)日本高血圧学会

  100. 中心脈圧および大動脈スティフネスは腎血流動態を介してアルブミン尿と関連する 腎動脈ドップラ法を用いた検討

    橋本 潤一郎, 岩倉 芳倫, 小野 美澄, 三島 英換, 竹内 陽一, 森本 玲, 工藤 正孝, 鈴木 健弘, 阿部 倫明, 佐藤 文俊, 阿部 高明, 伊藤 貞嘉

    日本高血圧学会総会プログラム・抄録集　34回　460-460　2011/10

    Publisher: (NPO)日本高血圧学会

  101. 腹膜アクセス 悪性高血圧における重度腎機能障害 維持透析導入時期の検討

    木村 朋由, 宮坂 康宣, 佐藤 功造, 石山 勝也, 岩渕 將, 土屋 善慎, 家入 伯夫, 高橋 和也, 佐藤 浩司, 水野 真一, 大江 佑治, 古川 暁子, 奥田 拓史, 阿部 倫明, 佐藤 光博, 宮崎 真理子, 野城 宏夫, 佐藤 寿伸, 田熊 淑男

    腎と透析　71　(別冊 腹膜透析2011)　335-337　2011/09

    Publisher: (株)東京医学社

    ISSN： 0385-2156

    More details Close

    悪性高血圧における重度腎機能障害について、維持透析導入時期から検討した。悪性高血圧に伴う重度腎機能障害症17例を経験し、透析導入時期に関する検討を行った。緊急に透析療法を要したのは6例、3例が維持透析継続、残り3例は透析を離脱できた。治療開始後1〜2週をピークに腎機能が改善する例が多く、維持透析決定・アクセス作製は最低2週の経過をみて行うのが望ましいと考えた。17例中7例に透析アクセス作製も1年以内に維持透析を要したのは3例のみ、2年の経過では離脱した1例が14ヵ月で再導入となったが、残りは2年間安定した腎機能経過であった。MAHA合併の有無が治療反応、腎予後を推測するうえで重要な所見と考えた。

  102. 両側腎動脈狭窄症と水腎症・大動脈周囲炎が合併した急性腎不全の1例

    阿部 倫明, 後藤 靖雄, 田熊 淑男, 佐藤 壽伸

    日本腎臓学会誌　53　(6)　956-956　2011/08

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  103. 超音波検査で診断された腎動脈狭窄症による末期腎不全の一例

    阿部 倫明, 寺澤 良夫, 田熊 淑男, 佐藤 寿伸

    超音波医学　38　(4)　499-500　2011/07

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

  104. 尿細管管腔内アルカリ化は蛋白尿による近位尿細管細胞酸化ストレスをPyk2経路を介して改善させる

    相馬 友和, 阿部 倫明, 森口 尚, 阿部 高明, 佐藤 博, 伊藤 貞嘉

    日本腎臓学会誌　53　(3)　433-433　2011/05

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  105. 長期/大量のRAS系阻害薬投与後にJG細胞の増生が認められたIgA腎症の1例

    阿部 倫明, 堀田 修, 家入 伯夫, 佐藤 光博, 木村 朋由, 城 謙輔, 北村 洋, 田熊 淑男, 佐藤 壽伸

    日本腎臓学会誌　53　(3)　438-438　2011/05

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  106. 腎動脈狭窄症による末期腎不全に対する腎動脈拡張術の可能性

    阿部 倫明, 大江 佑治, 田熊 淑男, 佐藤 寿伸

    日本透析医学会雑誌　44　(Suppl.1)　635-635　2011/05

    Publisher: (一社)日本透析医学会

    ISSN： 1340-3451

  107. 【ワンランク上の泌尿器科エマージェンシー】腎梗塞

    阿部 倫明, 佐藤 寿伸, 田熊 淑男, 庵谷 尚正

    臨床泌尿器科　65　(1)　39-47　2011/01

    Publisher: (株)医学書院

    ISSN： 0385-2393

  108. 尿細管管腔内アルカリ化は蛋白尿による近位尿細管細胞酸化ストレスを、Pyk2経路を介して改善させる

    相馬 友和, 阿部 倫明, 森口 尚, 高井 淳, 秋山 泰利, 豊原 敬文, 鈴木 健弘, 種本 雅之, 阿部 高明, 山本 雅之, 伊藤 貞嘉

    血管　34　(1)　32-33　2011/01

    Publisher: 日本心脈管作動物質学会

    ISSN： 0911-4637

  109. [特集] データブック アテローム血栓症の大規模臨床試験 Part3、動脈硬化性腎動脈狭窄症と腎機能障害の患者におけるステント留置療法 Invited

    阿部倫明, 伊藤貞嘉

    血栓と循環　19　(3)　313-316　2011

  110. Renal infarction Invited

    65　(1)　39-47　2011

    Publisher: 医学書院

    DOI： 10.11477/mf.1413102187 　

    ISSN： 0385-2393

  111. 脈圧増幅、末梢圧波反射、および大動脈スティフネスが拍動性動脈血流に及ぼす影響

    橋本 潤一郎, 岩倉 芳倫, 三島 英換, 竹内 陽一, 森本 玲, 工藤 正孝, 阿部 倫明, 種本 雅之, 佐藤 文俊, 阿部 高明, 伊藤 貞嘉

    日本高血圧学会総会プログラム・抄録集　33回　276-276　2010/10

    Publisher: (NPO)日本高血圧学会

  112. High glucose augments susceptibility of AT1R-induced NAD(P)H oxidase activation in mesangial cell

    Michiaki Abe, Tomokazu Souma, Yanagisawa-Miyazawa Noriko, Yasutoshi Akiyama, Takafumi Toyohara, Masayuki Tanemoto, Takaaki Abe, Hiroshi Sato, Masaaki Nakayama, Sadayoshi Ito

    ENDOCRINE JOURNAL　57　S400-S400　2010/03

    ISSN： 0918-8959

  113. 多発性骨転移後35年間長期生存している悪性褐色細胞腫の一例

    竹内 陽一, 三島 英換, 鈴木 健弘, 阿部 倫明, 種本 雅之, 阿部 高明, 伊藤 貞嘉

    日本内分泌学会雑誌　86　(1)　156-156　2010/03

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  114. ヒト大動脈培養細胞におけるメチルグリオキサールによる酸化ストレス産生機序について

    阿部 倫明

    日本応用酵素協会誌　(44)　80-81　2010/02

    Publisher: (公財)日本応用酵素協会

    ISSN： 0913-3348

  115. 腎血管性高血圧 Invited

    阿部倫明, 伊藤貞嘉

    病気と薬パーフェクトBOOK 薬局　増刊号61　(4)　533-538　2010

  116. 【高血圧 専門医の意見を聞くべきケースとタイミング】専門医への紹介が強く勧められるケース 二次性高血圧が疑われる場合 腎血管性高血圧

    阿部 倫明, 伊藤 貞嘉

    診断と治療　98　(1)　27-35　2010/01

    Publisher: (株)診断と治療社

    ISSN： 0370-999X

  117. 高糖状態によるメサンギウム細胞の前暴露はアンジオテンシンII刺激による酸化ストレスを増強させた Invited

    阿部 倫明

    東北医学雑誌　121　(2)　189-193　2009/12

    Publisher: 東北医学会

    ISSN： 0040-8700

  118. Acidification Aggravates Fatty Acid-Bound Albumin-Induced Superoxide Production in Renal Proximal Tubular Cells Through Activation of Pyk2 Pathways

    Tomokazu Souma, Michiaki Abe, Yasutoshi Akiyama, Takafumi Toyohara, Shiwaku O. Hiromi, Takehiro Suzuki, Masayuki Tanemoto, Takaaki Abe, Sadayoshi Ito

    HYPERTENSION　54　(4)　E84-E84　2009/10

    ISSN： 0194-911X

  119. 尿細管管腔内酸性化は脂肪酸結合アルブミンによる近位尿細管細胞からの活性酸素産生を増悪させる

    相馬 友和, 阿部 倫明, 秋山 泰利, 豊原 敬文, 塩飽 博美, 竹内 陽一, 三島 英換, 鈴木 健弘, 種本 雅之, 阿部 高明, 伊藤 貞嘉

    日本高血圧学会総会プログラム・抄録集　32回　172-172　2009/10

    Publisher: (NPO)日本高血圧学会

  120. ヒト腎臓特異的有機アニオントランスポーターSLCO4C1の転写活性調節と臨床応用

    鈴木 健弘, 豊原 敬文, 秋山 泰利, 相馬 友和, 竹内 陽一, 三島 英換, 阿部 倫明, 種本 雅之, 伊藤 貞嘉, 阿部 高明

    日本高血圧学会総会プログラム・抄録集　32回　236-236　2009/10

    Publisher: (NPO)日本高血圧学会

  121. 狭窄部血行動態指標と血行再建術による降圧効果の動脈硬化性腎動脈狭窄での検討

    種本 雅之, 竹内 陽一, 三島 英換, 相馬 友和, 秋山 泰利, 豊原 敬文, 鈴木 健弘, 阿部 倫明, 阿部 高明, 伊藤 貞嘉

    日本高血圧学会総会プログラム・抄録集　32回　313-313　2009/10

    Publisher: (NPO)日本高血圧学会

  122. スタチンによる血圧降下作用機序の解析

    豊原 敬文, 秋山 泰利, 竹内 陽一, 三島 英換, 相馬 友和, 鈴木 健弘, 阿部 倫明, 種本 雅之, 曽我 朋義, 伊藤 貞嘉, 阿部 高明

    日本高血圧学会総会プログラム・抄録集　32回　323-323　2009/10

    Publisher: (NPO)日本高血圧学会

  123. CKD、腎動脈狭窄症を合併した原発性アルドステロン症(PA)はどのように診断・治療するか 治療抵抗性高血圧を呈するDM腎症例の診断と治療を紹介する

    岩倉 芳倫, 佐藤 文俊, 森本 玲, 工藤 正孝, 阿部 倫明, 佐藤 博, 高橋 昭喜, 荒井 陽一, 笹野 公伸, 伊藤 貞嘉

    日本内分泌学会雑誌　85　(2)　719-719　2009/09

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  124. 経皮的腎動脈形成術の適応を決める際の狭窄部圧較差測定の重要性

    三島 英換, 竹内 陽一, 鈴木 健弘, 阿部 倫明, 種本 雅之, 阿部 高明, 伊藤 貞嘉

    日本内分泌学会雑誌　85　(2)　719-719　2009/09

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  125. レニン-アンジオテンシン系阻害薬と経皮的腎動脈形成術により腎血管性高血圧に伴うネフローゼ症候群が改善した一例

    竹内 陽一, 三島 英換, 鈴木 健弘, 阿部 倫明, 種本 雅之, 阿部 高明, 伊藤 貞嘉

    日本内分泌学会雑誌　85　(2)　724-724　2009/09

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  126. 腎動脈ステント留置後再狭窄の治療適応判定における腎動脈エコーの有用性

    竹内 陽一, 三島 英換, 秋山 泰利, 豊原 敬文, 鈴木 健弘, 阿部 倫明, 種本 雅之, 阿部 高明, 伊藤 貞嘉

    日本腎臓学会誌　51　(6)　692-692　2009/08

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  127. Low luminal pH aggravates fatty acid bound albumin induced O-2(.-) production in renal proximal tubular cell

    Tomokazu Souma, Michiaki Abe, Yasutoshi Akiyama, Takafumi Toyohara, Takehiro Suzuki, Hiromi O. Shiwaku, Masayuki Tanemoto, Takaaki Abe, Sadayoshi Ito

    FASEB JOURNAL　23　2009/04

    ISSN： 0892-6638

  128. ミネラルコルチコイドによるイオン輸送制御の分子機構

    種本 雅之, 豊原 敬文, 相馬 友和, 秋山 泰利, 岩倉 芳倫, 塩飽 浩美, 鈴木 健弘, 阿部 倫明, 阿部 高明, 伊藤 貞嘉

    日本内分泌学会雑誌　85　(1)　374-374　2009/04

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  129. 腎遠位尿細管イオンチャネルの機能局在を制御する分子機構

    種本 雅之, 豊原 敬文, 塩飽 浩美, 島 久登, 岩倉 芳倫, 相馬 友和, 秋山 泰利, 鈴木 健弘, 阿部 倫明, 阿部 高明, 伊藤 貞嘉

    日本腎臓学会誌　51　(3)　298-298　2009/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  130. 妊娠高血圧症候群8症例における血中エンドグリン濃度と血中ADMA濃度の検討

    秋山 泰利, 岩倉 芳倫, 相馬 友和, 豊原 敬文, 鈴木 健弘, 阿部 倫明, 種本 雅之, 阿部 高明, 伊藤 貞嘉

    日本腎臓学会誌　51　(3)　307-307　2009/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  131. フルバスタチンはオレイン酸結合アルブミン刺激に伴う尿細管酸化ストレスを抑制する

    相馬 友和, 阿部 倫明, 秋山 泰利, 豊原 敬文, 鈴木 健弘, 塩飽 博美, 種本 雅之, 阿部 高明, 伊藤 貞嘉

    日本腎臓学会誌　51　(3)　339-339　2009/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  132. 慢性腎臓病の病期分類からみた腎内血流評価について

    小泉 賢治, 阿部 倫明, 大平 未佳, 石塚 静江, 藤原 淳子, 渡邊 有美, 朱 万君, 阿部 高明, 賀来 満, 伊藤 貞嘉

    日本腎臓学会誌　51　(3)　346-346　2009/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  133. 腎遠位尿細管管腔側カリウムチャネルの機能的発現機構の解明

    島 久登, 種本 雅之, 相馬 友和, 秋山 泰利, 岩倉 芳倫, 塩飽 浩美, 豊原 敬文, 鈴木 健弘, 阿部 倫明, 阿部 高明, 伊藤 貞嘉

    日本腎臓学会誌　51　(3)　350-350　2009/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  134. LOW LUMINAL PH AGGRAVATES FATTY ACID BOUND ALBUMIN INDUCED O2 center dot- PRODUCTION IN RENAL PROXIMAL TUBULAR CELL

    Tomokazu Souma, Michiaki Abe, Yasutoshi Akiyama, Takafumi Toyohara, Hiromi O. Shiwaku, Takehiro Suzuki, Masayuki Tanemoto, Takaaki Abe, Sadayoshi Ito

    JOURNAL OF VASCULAR RESEARCH　46　99-99　2009

    ISSN： 1018-1172

  135. LOW LUMINAL pH AGGRAVATES FATTY ACID BOUD ALBUMIN INDUCED O-2(center dot-) PRODUCTION IN RENAL PROXIMAL TUBULAR CELL

    Tomokazu Souma, Michiaki Abe, Yasutoshi Akiyama, Takafumi Toyohara, Hiromi O. Shiwaku, Takehiro Suzuki, Masayuki Tanemoto, Takaaki Abe, Sadayoshi Ito

    JOURNAL OF PHYSIOLOGICAL SCIENCES　59　485-485　2009

    ISSN： 1880-6546

  136. 動脈硬化症 Invited

    阿部 倫明

    慢性腎臓病CKD−病態理解に基づいた予防と治療のあり方. [監修] 伊藤貞嘉・柏原直樹,　2009

  137. 【腎不全と血栓】急性腎不全 腎梗塞

    阿部 倫明, 伊藤 貞嘉

    血栓と循環　16　(4)　292-298　2008/12

    Publisher: (株)メディカルレビュー社

    ISSN： 0919-7036

  138. 高グルコースによるアンギオテンシンII刺激後NAD(P)Hオキシダーゼ活性化の増強調節機序について

    阿部 倫明, 宮澤 紀子, 豊原 敬史, 相馬 友和, 秋山 泰利, 鈴木 健弘, 塩飽 浩美, 種本 雅之, 阿部 高明, 伊藤 貞嘉

    日本高血圧学会総会プログラム・抄録集　31回　169-169　2008/10

    Publisher: (NPO)日本高血圧学会

  139. プラバスタチンは有機アニオントランスポーターを介して膵β細胞からのインスリン分泌を刺激する

    鈴木 健弘, 阿部 倫明, 豊原 敬文, 石井 晶子, 野口 直哉, 秋山 泰利, 相馬 友和, 塩飽 浩美, 種本 雅之, 伊藤 貞嘉, 阿部 高明

    日本高血圧学会総会プログラム・抄録集　31回　190-190　2008/10

    Publisher: (NPO)日本高血圧学会

  140. 妊娠高血圧症候群8症例における血中エンドグリン濃度の検討

    秋山 泰利, 相馬 友和, 豊原 敬文, 鈴木 健弘, 阿部 倫明, 種本 雅之, 阿部 高明, 伊藤 貞嘉

    日本高血圧学会総会プログラム・抄録集　31回　360-360　2008/10

    Publisher: (NPO)日本高血圧学会

  141. 褐色細胞腫および傍神経節腫の診断における随時尿メタネフリン分画・クレアチニン比の有用性について

    相馬 友和, 秋山 泰利, 豊原 敬文, 鈴木 健弘, 阿部 倫明, 種本 雅之, 阿部 高明, 伊藤 貞嘉

    日本高血圧学会総会プログラム・抄録集　31回　365-365　2008/10

    Publisher: (NPO)日本高血圧学会

  142. 生理的レベルの副腎皮質刺激が副腎静脈サンプリングの診断に及ぼす影響

    種本 雅之, 秋山 泰利, 相馬 友和, 鈴木 健弘, 阿部 倫明, 阿部 高明, 伊藤 貞嘉

    日本高血圧学会総会プログラム・抄録集　31回　367-367　2008/10

    Publisher: (NPO)日本高血圧学会

  143. メサンギウム細胞における高グルコース曝露がアンジオテンシンII刺激による酸化ストレス産生を増強させる機序について

    阿部 倫明, 宮澤 紀子, 豊原 敬文, 相馬 友和, 鈴木 健弘, 秋山 泰利, 塩飽 浩美, 種本 雅之, 阿部 高明, 伊藤 貞嘉

    日本内分泌学会雑誌　84　(2)　693-693　2008/09

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  144. 腎動脈起始部の腫瘤性病変により腎血管性高血圧を呈したと考えられる一例

    大平 未佳, 秋山 泰利, 阿部 倫明, 阿部 高明

    日本心臓病学会誌　2　(Suppl.I)　194-194　2008/08

    Publisher: (一社)日本心臓病学会

    ISSN： 1882-4501

  145. 重症心不全を合併した褐色細胞腫の一例

    岩根 尊, 関口 悟, 川岸 直樹, 赤松 順寛, 渡辺 道雄, 中島 範昭, 佐藤 和重, 宮城 重人, 武田 郁央, 中村 篤司, 福本 義弘, 縄田 淳, 杉村 宏一郎, 福井 重文, 阿部 高明, 阿部 倫明, 藤盛 啓成, 大内 憲明, 里見 進

    日本内分泌外科学会総会プログラム・抄録集　20回　74-74　2008/06

    Publisher: (一社)日本内分泌外科学会

  146. 『腎梗塞』 (血栓と循環)

    阿部倫明, 伊藤貞嘉

    血栓と循環　16　32-38　2008/04

  147. 副腎静脈サンプリングにおける極低量ACTH刺激の有用性

    種本 雅之, 相馬 友和, 阿部 倫明, 阿部 高明, 伊藤 貞嘉

    日本内分泌学会雑誌　84　(1)　214-214　2008/04

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  148. 褐色細胞腫および傍神経節腫への非イオン性ヨード造影剤使用に伴う合併症の検討

    相馬 友和, 秋山 泰利, 豊原 敬文, 鈴木 健弘, 阿部 倫明, 種本 雅之, 阿部 高明, 伊藤 貞嘉

    日本内分泌学会雑誌　84　(1)　252-252　2008/04

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  149. 健常者の腎動脈血流とアンジオテンシン受容体拮抗薬の影響

    大平 未佳, 阿部 倫明, 渡辺 さち子, 石塚 静江, 藤原 淳子, 小林 智恵, 阿部 高明

    超音波検査技術　33　(2)　187-187　2008/04

    Publisher: (一社)日本超音波検査学会

    ISSN： 1881-4506

  150. 腎動脈狭窄症の狭窄部圧格差と血行再建術の治療効果の関連

    種本 雅之, 秋山 泰利, 相馬 友和, 阿部 倫明, 阿部 高明, 伊藤 貞嘉

    日本腎臓学会誌　50　(3)　284-284　2008/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  151. トランスポーター研究の新展開 医療現場におけるトランスポーター研究の応用

    阿部 高明, 豊原 敬文, 秋山 泰利, 阿部 倫明, 鈴木 健弘, 種本 雅之, 野口 直哉, 高沢 伸

    薬剤学: 生命とくすり　68　(Suppl.)　24-24　2008/04

    Publisher: (公社)日本薬剤学会

    ISSN： 0372-7629

    eISSN： 2188-3149

  152. けんさ質問箱 超音波検査での腎動脈狭窄の計測ポイント

    大平 未佳, 阿部 倫明

    検査と技術　36　(3)　283-285　2008/03

    Publisher: (株)医学書院

    ISSN： 0301-2611

  153. 常用量の漢方薬内服中に横紋筋融解症を呈した1例

    豊原 敬文, 種本 雅之, 宇留野 晃, 阿部 倫明, 阿部 高明, 伊藤 貞哉

    日本腎臓学会誌　50　(2)　135-139　2008/03

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  154. RAS阻害およびPTRAにてネフローゼ域蛋白尿からの著明な改善を得た腎血管性高血圧の一例

    相馬友和, 閻国珊, 秋山泰利, 豊原敬文, 鈴木健弘, 阿部倫明, 種本雅之, 阿部高明, 伊藤貞嘉

    日本腎臓学会誌　50　(6)　2008

    ISSN： 0385-2385

  155. 常用量の漢方薬内服中に横紋筋融解症を呈した１症例． Peer-reviewed

    豊原敬文, 種本雅之, 宇留野晃, 阿部倫明, 阿部高明, 伊藤貞嘉

    日本腎臓学会誌　50　135-139　2008

  156. 腎尿細管におけるNa負荷によるRedox調節 高血圧発症・増悪に関わるNaの役割について

    阿部 倫明, 伊藤 貞嘉, Cowley Jr. Allen AW

    血管　30　(4)　101-108　2007/12

    Publisher: 日本心脈管作動物質学会

    ISSN： 0911-4637

    More details Close

    尿細管内へ到達するナトリウムイオン(Na+)の増加が酸化ストレスを亢進させるかどうかを調べるために、正常血圧ラットの上行脚(TAL)をNa+溶液で微小灌流し、尿細管細胞内の活性酸素(O2-)と一酸化窒素(NO)の変化を各々測定した。灌流速度を一定に保ち、尿細管内のNa+灌流液の濃度を60mMから149mMに上昇すると腎髄質のTAL(mTAL)のO2-産生が増加した。また、Na+濃度を149mMから60mMに低下させるとmTALのNOが増加した。高Na+濃度灌流下では、低流速時でもNO基礎分泌は全く認めなかった。低Na+濃度灌流下では、灌流速度が速くなるにつれて尿細管におけるNOの基礎分泌が減弱した。高Na+液を灌流すると、流速に関わらずO2-が産生した。低濃度Na液の灌流時、低流速から高流速に変化させた時に活性酸素は増加した。

  157. 腎尿細管におけるNa負荷によるRedox調節について

    阿部 倫明, 伊藤 貞嘉

    日本高血圧学会総会プログラム・抄録集　30回　172-172　2007/10

    Publisher: (NPO)日本高血圧学会

  158. メサンギウム細胞におけるアンギオテンシンII負荷と糖負荷による酸化ストレス反応性の相違について

    阿部 倫明, 宮澤 紀子, 豊原 敬文, 中山 謙二, 鈴木 健弘, 塩飽 浩美, 種本 雅之, 阿部 高明, 伊藤 貞嘉

    日本高血圧学会総会プログラム・抄録集　30回　226-226　2007/10

    Publisher: (NPO)日本高血圧学会

  159. 超音波パルスドプラ法を用いたARBの腎動脈血流に及ぼす影響

    大平 未佳, 藤原 淳子, 石塚 静江, 佐藤 淳子, 渡辺 さち子, 阿部 倫明, 阿部 高明, 賀来 満夫

    日本高血圧学会総会プログラム・抄録集　30回　293-293　2007/10

    Publisher: (NPO)日本高血圧学会

  160. 術前MDCTにて副腎結節性病変を認めなかった原発性アルドステロン症の自験例に関する検討

    森本 玲, 佐藤 文俊, 村上 治, 宇留野 晃, 阿部 倫明, 種本 雅之, 阿部 高明, 伊藤 貞嘉, 高瀬 圭, 山田 隆之, 石橋 忠司, 高橋 昭喜, 石戸谷 滋人, 佐藤 信, 荒井 陽一, 鈴木 貴, 笹野 公伸

    日本内分泌学会雑誌　83　(2)　460-460　2007/09

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  161. アンジオテンシンIIとブドウ糖は異なる様式でメサンギウム細胞の酸化ストレスを産生させた

    阿部 倫明, 宮澤 紀子, 豊原 敬文, 中山 謙二, 鈴木 健弘, 秋山 泰利, 塩飽 浩美, 種本 雅之, 阿部 高明, 伊藤 貞嘉

    日本内分泌学会雑誌　83　(2)　589-589　2007/09

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  162. Pravastatinは有機アニオントランスポーターを介して膵β細胞からのインスリン分泌を刺激する

    阿部 倫明, 豊原 敬文, 鈴木 健弘, 秋山 泰利, 種本 雅之, 伊藤 貞嘉, 阿部 高明

    日本内分泌学会雑誌　83　(2)　593-593　2007/09

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  163. 近位尿細管特異的GFP-tTA発現マウスの作製と解析

    豊原 敬文, 鈴木 健弘, 阿部 倫明, 秋山 泰利, 種本 雅之, 伊藤 貞嘉, 阿部 高明

    日本内分泌学会雑誌　83　(2)　595-595　2007/09

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  164. 経皮経管腎動脈拡張術後の再狭窄がロサルタン内服後の正常血圧の維持により改善した一例

    秋山 泰利, 種本 雅之, 豊原 敬文, 鈴木 健弘, 阿部 倫明, 阿部 高明, 伊藤 貞嘉

    日本内分泌学会雑誌　83　(2)　598-598　2007/09

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  165. 糖尿病性腎症の寛解を目指した新しい治療 糖尿病性腎症における酸化ストレス、炎症の関わりとその治療戦略

    小川 晋, 森 建文, 阿部 倫明, 奈古 一宏, 伊藤 貞嘉

    日本腎臓学会誌　49　(3)　215-215　2007/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  166. 血管内皮細胞でのメチルグリオキサールによる酸化ストレスの産生機序について

    宮沢 紀子, 阿部 倫明, 寺脇 博之, 中山 恵輔, 中山 昌明, 伊藤 貞嘉

    日本腎臓学会誌　49　(3)　315-315　2007/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  167. 狭窄部最小径の腎動脈狭窄の治療指標としての有用性

    種本 雅之, 宇留野 晃, 阿部 倫明, 佐藤 文俊, 阿部 高明, 伊藤 貞嘉

    日本腎臓学会誌　49　(3)　321-321　2007/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  168. 近位尿細管特異的遺伝子調節マウスの作製と解析

    豊原 敬文, 鈴木 健弘, 阿部 倫明, 種本 雅之, 柴田 英介, 進藤 智彦, 島 彦仁, 伊藤 貞嘉, 阿部 高明

    日本腎臓学会誌　49　(3)　338-338　2007/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  169. 原発性アルドステロン症はコモンディジーズか? 原発性アルドステロン症の多様性 スクリーニング、確定診断におけるレニン・アンジオテンシン系抑制とACTH反応性の意義

    佐藤 文俊, 森本 玲, 宇留野 晃, 阿部 倫明, 種本 雅之, 阿部 高明, 荒井 陽一, 笹野 公伸, 石橋 忠司, 伊藤 貞嘉

    日本内分泌学会雑誌　83　(1)　38-38　2007/04

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  170. 副腎静脈サンプリングの適応と解釈 原発性アルドステロン症における副腎静脈サンプリングの手術適応の診断 左副腎静脈のカテーテル位置の重要性

    佐藤 文俊, 森本 玲, 宇留野 晃, 阿部 倫明, 種本 雅之, 阿部 高明, 荒井 陽一, 笹野 公伸, 石橋 忠司, 伊藤 貞嘉

    日本内分泌学会雑誌　83　(1)　77-77　2007/04

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  171. Pravastatinは有機アニオントランスポーターを介して膵β細胞からのインスリン分泌を刺激する

    豊原 敬文, 阿部 倫明, 石井 晶子, 塩飽 浩美, 鈴木 健弘, 柴田 英介, 種本 雅之, 伊藤 貞嘉, 阿部 高明

    日本内分泌学会雑誌　83　(1)　115-115　2007/04

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  172. 腎血管性高血圧の画像診断における狭窄部最小径の有用性

    種本 雅之, 阿部 倫明, 宇留野 晃, 佐藤 文俊, 阿部 高明, 伊藤 貞嘉

    日本内分泌学会雑誌　83　(1)　206-206　2007/04

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  173. 原発性アルドステロン症の病型鑑別と頻度

    佐藤 文俊, 阿部 高明, 森本 玲, 宇留野 晃, 阿部 倫明, 種本 雅之, 荒井 陽一, 笹野 公伸, 石橋 忠司, 伊藤 貞嘉

    日本内科学会雑誌　96　(Suppl.)　138-138　2007/02

    Publisher: (一社)日本内科学会

    ISSN： 0021-5384

  174. DEVELOPMENT OF THE RENAL PROXIMAL TUBULE SPECIFIC-INDUCIBLE GENE EXPRESSION SYSTEM

    Takafumi Toyohara, Takehiro Suzuki, Michiaki Abe, Yasutoshi Akiyama, Hiromi Shiwaku, Eisuke Shibata, Masayuki Tanemoto, Sadayoshi Ito, Takaaki Abe

    DRUG METABOLISM REVIEWS　39　331-331　2007

    ISSN： 0360-2532

  175. 尿細管における酸化ストレス増幅機構の潜在性について

    阿部 倫明, 宮沢 紀子, 豊原 敬文, 柴田 英介, 鈴木 健弘, 塩飽 浩美, 種本 雅之, 佐藤 文俊, 阿部 高明, Cowley Jr. Allen W, 伊藤 貞嘉

    血管　30　(1)　32-32　2007/01

    Publisher: 日本心脈管作動物質学会

    ISSN： 0911-4637

  176. 腎尿細管におけるNa負荷によるRedox調節について

    阿部 倫明, Cowley Jr. Allen W, 伊藤 貞嘉

    血管　30　(1)　32-32　2007/01

    Publisher: 日本心脈管作動物質学会

    ISSN： 0911-4637

  177. 血管内皮細胞でのメチルグリオキサールによる酸化ストレスの産生機序について

    宮澤 紀子, 阿部 倫明, 寺脇 博之, 中山 恵輔, 中山 昌明, 伊藤 貞嘉

    血管　30　(1)　40-40　2007/01

    Publisher: 日本心脈管作動物質学会

    ISSN： 0911-4637

  178. Chronic or acute interaction of angiotensin II on oxidative stress production by glucose pretreated mesangial cells

    Noriko Miyazawa, Michiaki Abe, Takafumi Toyohara, Takehiro Suzuki, Kenji Nakayama, Akiko Ishii, Hiromi Shiwaku, Eisuke Shibata, Masayuki Tanemoto, Fumitoshi Satoh, Takaaki Abe, Sadayoshi Ito

    JOURNAL OF HYPERTENSION　24　181-181　2006/12

    ISSN： 0263-6352

  179. Hydrogen peroxide, produced by high sodium stimulation, potentially stimulates the production of superoxide anion in mTAL

    Michiaki Abe, Paul O'Connor, Takafumi Toyohara, Takehiro Suzuki, Masayuki Tanemoto, Takaaki Abe, Sadayoshi Ito, Allen W. Cowley

    JOURNAL OF HYPERTENSION　24　397-397　2006/12

    ISSN： 0263-6352

  180. Effects of sarpogrelate hydrochloride on metabolic function

    Michiaki Abe, Akiko Ishii, Takehiro Suzuki, Takafumi Toyohara, Hiromi Shiwaku, Ryo Morimoto, Tatsuji Chaki, Masayuki Tanemoto, Toshifumi Satoh, Toshiaki Abe, Sadayoshi Ito, Takaaki Abe

    JOURNAL OF HYPERTENSION　24　353-353　2006/12

    ISSN： 0263-6352

  181. 血管エコー検査シリーズ どう撮り,どう読むか? 腎動脈エコー 病変を読む

    阿部 倫明, 大平 未佳, 伊藤 貞嘉

    Vascular Lab　3　(3)　346-352　2006/08

    Publisher: (株)メディカ出版

    ISSN： 1349-4023

  182. 腎動脈エコーが腎血管性高血圧の診断に有用であった3症例

    豊原 敬文, 宇留野 晃, 阿部 倫明, 種本 雅之, 佐藤 文俊, 阿部 高明, 竹内 和久, 伊藤 貞嘉

    日本腎臓学会誌　48　(6)　597-597　2006/08

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  183. Aidosterone-producing adenoma accompanied with renal artery stenosis

    Masayuki Tanemoto, Kenji Honkura, Michiaki Abe, Fumitoshi Satoh, Takaaki Abe, Sadayoshi Ito

    JOURNAL OF NEPHROLOGY　19　(4)　540-542　2006/07

    ISSN： 1121-8428

  184. 塩酸サルポグレラートによる糖尿病性腎症の改善効果

    阿部 倫明, 鈴木 健弘, 石井 晶子, 豊原 敬文, 塩飽 浩美, 森本 玲, 茶木 辰治, 種本 雅之, 佐藤 文俊, 竹島 浩, 阿部 俊明, 伊藤 貞嘉, 阿部 高明

    日本腎臓学会誌　48　(3)　238-238　2006/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  185. 塩酸サルポグレラートの代謝機能における作用の検討

    阿部 倫明, 石井 晶子, 鈴木 健弘, 豊原 敬文, 塩飽 浩美, 森本 玲, 茶木 辰治, 種本 雅之, 阿部 俊明, 伊藤 貞嘉, 阿部 高明

    糖尿病　49　(Suppl.1)　S247-S247　2006/04

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

  186. メサンジウム細胞におけるアンジオテンシンIIとグルコースの共依存的活性酸素合成について

    宮沢 紀子, 阿部 倫明, 中山 謙二, 豊原 敬文, 鈴木 健弘, 種本 雅之, 佐藤 文俊, 阿部 高明, 伊藤 貞嘉

    日本腎臓学会誌　48　(3)　274-274　2006/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  187. アルドステロンと生活習慣病における臓器障害 原発性アルドステロン症からみたアルドステロンの臓器障害作用

    佐藤 文俊, 中村 匡宏, 森本 玲, 種本 雅之, 阿部 倫明, 宇留野 晃, 荒井 陽一, 笹野 公伸, 石橋 忠司, 阿部 高明, 伊藤 貞嘉

    日本内分泌学会雑誌　82　(1)　36-36　2006/04

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  188. 甲状腺ホルモントランスポーター遺伝子群の単離と機能解析

    鈴木 健弘, 三日市 剛, 茶木 辰治, 森本 玲, 豊原 敬文, 阿部 倫明, 佐藤 文俊, 種本 雅之, 阿部 高明, 伊藤 貞嘉

    日本内分泌学会雑誌　82　(1)　96-96　2006/04

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  189. 塩酸サルポグレラートによる代謝作用の検討

    阿部 倫明, 鈴木 健弘, 石井 晶子, 豊原 敬文, 塩飽 浩美, 森本 玲, 茶木 辰治, 種本 雅之, 佐藤 文俊, 竹島 浩, 阿部 俊明, 伊藤 貞嘉, 阿部 高明

    日本内分泌学会雑誌　82　(1)　137-137　2006/04

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  190. Synergistic interaction of angiotensin II and glucose in superoxide production by mesangial cells

    N Miyazawa, M Abe, K Nakayama, T Suzuki, A Akiko, H Shiwaku, M Tanemoto, F Satoh, T Abe, S Ito

    FASEB JOURNAL　20　(5)　A1456-A1456　2006/03

    ISSN： 0892-6638

  191. 【糖尿病腎症 進展阻止・寛解と発症予防を目指して】 成因 腎血行動態 (最新医学)

    阿部倫明, 伊藤貞嘉

    最新医学　61　(1)　31-37　2006/01

  192. 【糖尿病腎症 進展阻止・寛解と発症予防を目指して】成因 腎血行動態

    阿部 倫明, 伊藤 貞嘉

    最新医学　61　(1)　31-37　2006/01

    Publisher: (株)最新医学社

    ISSN： 0370-8241

  193. 【糖尿病腎症 進展阻止・寛解と発症予防を目指して】 成因 腎血行動態 (最新医学)

    最新医学　61　(1)　31-37　2006

  194. 海外通信：ウィスコンシン医科大学での留学を終えて Invited

    阿部 倫明

    CARDIAC PRACTICE　17　(1)　95-97　2006

  195. 腎動脈エコー：病変を読む Invited

    阿部倫明, 大平未佳, 伊藤貞嘉

    Vascular Lab　3　78-84　2006

  196. 【マクラデンサの不思議】 TGFと高血圧 (腎と透析)

    阿部倫明

    腎と透析　59　(5)　793-797　2005/11

  197. 【マクラデンサの不思議】TGFと高血圧

    阿部 倫明

    腎と透析　59　(5)　793-797　2005/11

    Publisher: (株)東京医学社

    ISSN： 0385-2156

  198. 多発微小腺腫による原発性アルドステロン症の一例 治療決定のための選択的副腎静脈サンプリングと病理診断における3βHSD染色の意義

    佐藤 文俊, 森本 玲, 杉浦 章, 宇留野 晃, 阿部 倫明, 種本 雅之, 阿部 高明, 佐藤 明弘, 石橋 忠司, 石戸谷 滋人, 荒井 陽一, 鈴木 貴, 笹野 公伸, 伊藤 貞嘉

    日本内分泌学会雑誌　81　(2)　457-457　2005/09

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  199. 早朝高血圧に対する新規ARBオルメサルタンによる介入 尿中アルブミン減少効果について

    佐藤 文俊, 森本 玲, 宇留野 晃, 阿部 倫明, 種本 雅之, 阿部 高明, 伊藤 貞嘉

    日本内分泌学会雑誌　81　(2)　558-558　2005/09

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  200. Pitavastatinによる血清脂質改善・抗動脈硬化作用の臨床的検討

    森本 玲, 佐藤 文俊, 宇留野 晃, 阿部 倫明, 種本 雅之, 阿部 高明, 伊藤 貞嘉

    日本内分泌学会雑誌　81　(2)　563-563　2005/09

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  201. アンジオテンシン受容体拮抗薬テルミサルタンとオルメサルタンは脂肪細胞で異なる機序により分化を誘導する

    鈴木 健弘, 茶木 辰治, Guodong Zheng, 森本 玲, 石井 晶子, 阿部 倫明, 佐藤 文俊, 種本 雅之, 伊藤 貞嘉, 阿部 高明

    日本高血圧学会総会プログラム・抄録集　28回　53-53　2005/09

    Publisher: (NPO)日本高血圧学会

  202. 原発性アルドステロン症の局在診断における副腎静脈サンプリングと最新型16列MDCTの有用性

    佐藤 文俊, 種本 雅之, 中村 匡宏, 阿部 倫明, 宇留野 晃, 森本 玲, 佐藤 明弘, 高瀬 圭, 石戸谷 滋人, 荒井 陽一, 鈴木 貴, 笹野 公伸, 石橋 忠司, 阿部 高明, 伊藤 貞嘉

    日本高血圧学会総会プログラム・抄録集　28回　59-59　2005/09

    Publisher: (NPO)日本高血圧学会

  203. 腎髄質のCOX-2は,Dahl食塩感受性ラットの食塩誘発高血圧を軽減する

    阿部 倫明, 伊藤 貞嘉, アラン・カウリー

    日本高血圧学会総会プログラム・抄録集　28回　128-128　2005/09

    Publisher: (NPO)日本高血圧学会

  204. 腎動脈狭窄症における血管内超音波エコーによる診断および治療法の検討

    宇留野 晃, 阿部 倫明, 種本 雅之, 佐藤 文俊, 竹内 和久, 伊藤 貞嘉

    日本高血圧学会総会プログラム・抄録集　28回　149-149　2005/09

    Publisher: (NPO)日本高血圧学会

  205. 腎動脈狭窄の原因診断と治療法の選択における血管内超音波検査(IVUS)の有効性

    宇留野 晃, 種本 雅之, 阿部 倫明, 佐藤 文俊, 阿部 高明, 竹内 和久, 伊藤 貞嘉

    日本腎臓学会誌　47　(6)　712-712　2005/08

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  206. 拡張困難な腎動脈狭窄に対するcutting balloonの効果とその適応

    種本 雅之, 茶木 辰治, 阿部 倫明, 佐藤 文俊, 阿部 高明, 石橋 忠司, 竹内 和久, 伊藤 貞嘉

    日本腎臓学会誌　47　(3)　342-342　2005/05

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  207. アンジオテンシン受容体ブロッカーテルミサルタンはアディポネクチンの転写を活性化させる

    阿部 高明, 森本 玲, 竹内 陽一, 鈴木 健弘, 鈴木 恵綾, 茶木 辰治, 阿部 倫明, 種本 雅之, 佐藤 文俊, 伊藤 貞嘉

    日本内分泌学会雑誌　81　(1)　156-156　2005/04

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  208. 【マクラデンサの不思議】 TGFと高血圧 (腎と透析)

    腎と透析　59　(5)　793-797　2005

  209. 原発性アルドステロン症診断のクリニカルパスとACTH負荷両側副腎静脈血同時採血法

    佐藤 文俊, 阿部 高明, 種本 雅之, 在原 善英, 阿部 倫明, 鈴木 恵綾, 茶木 辰治, 石戸谷 滋人, 鈴木 貴, 荒井 陽一, 笹野 公伸, 石橋 忠司, 伊藤 貞嘉

    東京女子医科大学雑誌　74　(9〜10)　598-598　2004/10

    Publisher: 東京女子医科大学学会

    ISSN： 0040-9022

  210. 腎髄質内のスーパーオキサイドと一酸化窒素の高血圧に対する生理学的意義

    森 建文, アレン・W・カウリー, 阿部 倫明, 阿部 高明, 種本 雅之, 佐藤 文俊, 伊藤 貞嘉

    日本高血圧学会総会プログラム・抄録集　27回　39-39　2004/10

    Publisher: (NPO)日本高血圧学会

  211. ヒト腎臓特異的に発現しジゴキシン輸送を担う新規有機アニオントランスポーターの単離と機能解析及びラット相同遺伝子の同定

    鈴木 健弘, 三日市 剛, 小野川 徹, 種本 雅之, 水溜 浩弥, 岡田 匡弘, 茶木 辰治, 増田 智先, 徳井 太郎, 江藤 伸晃, 阿部 倫明, 佐藤 文俊, 海野 倫明, 菱沼 隆則, 乾 賢一, 後藤 順一, 伊藤 貞嘉, 阿部 高明

    日本高血圧学会総会プログラム・抄録集　27回　48-48　2004/10

    Publisher: (NPO)日本高血圧学会

  212. 原発性アルドステロン症の局在診断 左副腎静脈サンプリングでのカテーテル先端位置の重要性と16チャンネルCTを用いた右副腎静脈への狙い撃ちサンプリング

    佐藤 文俊, 阿部 高明, 種本 雅之, 在原 善英, 阿部 倫明, 鈴木 恵綾, 茶木 辰治, 石橋 忠司, 伊藤 貞嘉

    日本内分泌学会雑誌　80　(1)　112-112　2004/04

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  213. 特集：透析患者の血圧管理の実際−生理的血圧維持機構 Invited

    阿部倫明, 伊藤貞嘉

    臨床透析　13　2004

  214. Molecular characterization of human and rat organic anion transporter OATP-D

    H Adachi, T Suzuki, M Abe, N Asano, H Mizutamari, M Tanemoto, T Nishio, T Onogawa, T Toyohara, S Kasai, F Satoh, M Suzuki, T Tokui, M Unno, T Shimosegawa, S Matsuno, S Ito, T Abe

    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY　285　(6)　F1188-F1197　2003/12

    DOI： 10.1152/ajprenal.00402.2002 　

    ISSN： 1931-857X

  215. 迅速かつ信頼性の高い原発性アルドステロン症の局在診断の重要性-ACTH負荷15分後副腎静脈血同時採血法の検討

    佐藤 文俊, 阿部 高明, 種本 雅之, 阿部 倫明, 石戸谷 滋人, 鈴木 貴, 荒井 陽一, 笹野 公伸, 石橋 忠司, 伊藤 貞嘉

    日本高血圧学会総会プログラム・抄録集　26回　48-48　2003/10

    Publisher: (NPO)日本高血圧学会

  216. 若年性高血圧をきたしたレニン産生腫瘍の治療及び遺伝子発現

    茶木 辰治, 阿部 高明, 種本 雅之, 阿部 倫明, 鈴木 恵綾, 鈴木 健弘, 佐藤 文俊, 伊藤 貞嘉

    日本高血圧学会総会プログラム・抄録集　26回　90-90　2003/10

    Publisher: (NPO)日本高血圧学会

  217. The partial adrenalectomy can not be recommended for the adrenal gland with aldosterone producing adenoma

    SATO Fumitoshi, ABE Takaaki, TANEMOTO Masayuki, SUZUKI Keishun, CHAKI Tatsuji, ABE Noriaki, ARIWARA Yoshihide, ARIMA Shuji, ISHIDOYA Shigeto, SUZUKI Takashi, SASANO Kiminobu, ARAI Yoichi, ISHIBASHI Tadashi, ITO Sadayoshi

    20　(3)　260-261　2003/09/30

    ISSN： 0914-9953

  218. 腎動脈解離が突然の昇圧の誘因となった一例

    笠井 暁史, 種本 雅之, 阿部 高明, 在原 善英, 佐藤 文俊, 阿部 倫明, 竹内 和久, 伊藤 貞嘉, 佐藤 明弘, 石橋 忠司

    日本腎臓学会誌　45　(6)　562-562　2003/08

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  219. ヒト腎臓のみに発現する新規有機アニオントランスポーターの単離と機能解析

    阿部 高明, 鈴木 健弘, 阿部 倫明, 種本 雅之, 伊藤 貞嘉

    日本腎臓学会誌　45　(3)　204-204　2003/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  220. カリウムチャネルKir5.1/Kir4.1heteromerによる酸・塩基平衡の調節

    種本 雅之, 阿部 倫明, 阿部 高明, 伊藤 貞嘉

    日本腎臓学会誌　45　(3)　225-225　2003/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  221. 若年性高血圧をきたしたレニン産生腫瘍の一例

    阿部 高明, 種本 雅之, 阿部 倫明, 鈴木 健弘, 竹内 和久, 石橋 忠司, 新井 陽一, 伊藤 貞嘉

    日本腎臓学会誌　45　(3)　285-285　2003/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  222. 腎血管性高血圧における経皮経管的血行再建術後の予後因子の検索

    阿部 倫明, 阿部 高明, 種本 雅之, 佐藤 文俊, 笠井 暁史, 有馬 秀二, 竹内 和久, 石橋 忠司, 伊藤 貞嘉

    日本腎臓学会誌　45　(3)　304-304　2003/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  223. 興味ある症例 特異な臨床像を呈したCushing病 Preclinical Cushing病,末端肥大症,左副腎結節を伴う特発性アルドステロン症を合併した重症高血圧の1例

    阿部 倫明, 佐藤 文俊, 阿部 高明, 種本 雅之, 在原 善英, 竹内 和久, 石橋 忠司, 笹野 公伸, 池田 秀敏, 伊藤 貞嘉

    日本内分泌学会雑誌　79　(1)　62-62　2003/04

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  224. 興味ある症例 副腎皮質疾患 画像診断のみでは治療を誤ってしまう原発性アルドステロン症の4つのパターン ACTH負荷選択的副腎静脈血サンプリング法の必須性

    佐藤 文俊, 阿部 高明, 種本 雅之, 阿部 倫明, 在原 善英, 石戸谷 滋人, 荒井 陽一, 笹野 公伸, 石橋 忠司, 伊藤 貞嘉

    日本内分泌学会雑誌　79　(1)　78-78　2003/04

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  225. 血管内皮に発現している有機アニオントランスポーター群

    阿部 倫明, 阿部 高明, 鈴木 健弘, 種本 雅之, 佐藤 文俊, 伊藤 貞嘉

    日本内分泌学会雑誌　79　(1)　220-220　2003/04

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  226. 大動脈における潰瘍の発生頻度の検討 宮古病院における過去2年間の解剖例から

    岩手県立宮古病院医学雑誌　6　15-17　2003

  227. 動脈硬化性病変が関与した上行大動脈穿孔(破裂)の一例

    阿部 倫明, 岡村 将史, 中村 明浩, 星 信夫

    Circulation Journal　66　(Suppl.III)　1010-1010　2002/10

    Publisher: (一社)日本循環器学会

    ISSN： 1346-9843

  228. 【保存期腎不全 病態生理とその治療】高血圧と降圧薬

    阿部 倫明, 伊藤 貞嘉

    腎と透析　53　(4)　457-462　2002/10

    Publisher: (株)東京医学社

    ISSN： 0385-2156

  229. 若年性高血圧をきたしたレニン産生腫瘍の一例

    阿部 高明, 種本 雅之, 佐藤 文俊, 阿部 倫明, 鈴木 健弘, 竹内 和久, 伊藤 貞嘉, 石橋 忠司, 石戸谷 滋人, 新井 陽一

    日本内分泌学会雑誌　78　(2)　450-450　2002/09

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  230. ヒト及びラット血管内皮細胞に発現している有機アニオントランスポーター遺伝子群

    阿部 倫明, 阿部 高明, 鈴木 健弘, 種本 雅之, 佐藤 文俊, 伊藤 貞嘉

    日本内分泌学会雑誌　78　(2)　458-458　2002/09

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  231. メチラボン療法が奏効したCushing症候群による心不全の2例

    佐藤 文俊, 阿部 倫明, 阿部 高明, 種本 雅之, 伊藤 貞嘉

    日本内分泌学会雑誌　78　(2)　463-463　2002/09

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  232. ステロイドとミゾリビンが奏効した腎アミロイドーシスの一例

    岡村 将史, 阿部 倫明, 鈴木 健弘, 種本 雅之, 阿部 高明, 木村 朋由, 笠井 暁史, 有馬 秀二, 佐藤 文俊, 在原 善英, 佐藤 博, 永井 謙一, 伊藤 貞嘉

    日本腎臓学会誌　44　(6)　620-620　2002/08

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  233. 精査入院中にバセドウ病の再発が認められた褐色細胞腫の一例

    阿部 倫明, 谷 淳一, 関野 慎, 藤井 正実, 後藤 英雄, 佐藤 隆一, 大堀 久詔, 菅原 俊幸, 熊谷 利信, 永井 謙一

    岩手県立宮古病院医学雑誌　5　4-10　2001/11

    Publisher: 岩手県立宮古病院

    ISSN： 0917-1177

  234. ポリADPリボース合成酵素によるReg遺伝子の転写調節機構

    秋山 貴子, 中川 圭, 小林 誠一, 那谷 耕司, 野口 直哉, 阿部 倫明, Shervani Nausheen J, 池田 崇之, 高沢 伸, 松野 正紀

    Diabetes Frontier　12　(5)　660-661　2001/10

    Publisher: (株)メディカルレビュー社

    ISSN： 0915-6593

  235. LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers

    T Abe, M Unno, T Onogawa, T Tokui, TN Kondo, R Nakagomi, H Adachi, K Fujiwara, M Okabe, T Suzuki, K Nunoki, E Sato, M Kakyo, T Nishio, J Sugita, N Asano, M Tanemoto, M Seki, F Date, K Ono, Y Kondo, K Shiiba, M Suzuki, H Ohtani, T Shimosegawa, K Iinuma, H Nagura, S Ito, S Matsuno

    GASTROENTEROLOGY　120　(7)　1689-1699　2001/06

    DOI： 10.1053/gast.2001.24804 　

    ISSN： 0016-5085

  236. Identification of thyroid hormone transporters humans: Different molecules are involved in a tissue-specific manner

    K Fujiwara, H Adachi, T Nishio, M Unno, T Tokui, M Okabe, T Onogawa, T Suzuki, N Asano, M Tanemoto, M Seki, K Shiiba, M Suzuki, Y Kondo, K Nunoki, T Shimosegawa, K Iinuma, S Ito, S Matsuno, T Abe

    ENDOCRINOLOGY　142　(5)　2005-2012　2001/05

    DOI： 10.1210/en.142.5.2005 　

    ISSN： 0013-7227

  237. 心窩部痛を主訴に発見された褐色細胞腫の1例

    阿部 倫明, 谷 淳一, 関野 慎, 藤井 正実, 後藤 英雄, 佐藤 隆一, 熊谷 利信, 酒井 寿郎, 伊藤 貞嘉, 永井 謙一

    岩手県立病院総合学会講演集　2回　81-81　2000/09

    Publisher: 岩手県立病院総合学会事務局

  238. Isolation and functional expression of a receptor for Reg protein

    H Okamoto, S Kobayashi, T Akiyama, K Nata, T Ikeda, M Abe, M Tajima, NJ Shervani, M Unno, S Matsuno, H Sasaki, S Takasawa

    DIABETES　49　A44-A44　2000/05

    ISSN： 0012-1797

  239. Transcriptional activation of Reg (regenerating gene) by nicotinamide

    H Okamoto, T Akiyama, M Tajima, K Nata, S Kobayashi, M Abe, NJ Shervani, M Unno, T Uchiyama, S Matsuno, S Takasawa

    DIABETES　49　A256-A256　2000/05

    ISSN： 0012-1797

  240. ニコチン酸アミドのReg遺伝子発現増強効果

    秋山 貴子, 小林 誠一, 野口 直哉, 田島 みのり, 那谷 耕司, 阿部 倫明, 池田 崇之, 高澤 伸, 岡本 宏

    糖尿病　43　(Suppl.1)　192-192　2000/04

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

    eISSN： 1881-588X

  241. 新規ヒトREGファミリー遺伝子(REG III)の発現 その構造,発現,染色体座位

    劉 一, 那谷 耕司, 阿部 倫明, 高澤 伸, 岡本 宏

    糖尿病　43　(Suppl.1)　191-191　2000/04

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

    eISSN： 1881-588X

  242. Reg蛋白受容体の単離 その構造と機能発現

    小林 誠一, 秋山 貴子, 那谷 耕司, 阿部 倫明, Shervani Nausheen, 佐々木 英忠, 高澤 伸, 岡本 宏

    糖尿病　43　(Suppl.1)　192-192　2000/04

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

    eISSN： 1881-588X

  243. 膵ランゲルハンス島で発現している新しいリアノジン型受容体の構造,発現,機能

    黒木 実智雄, 那谷 耕司, 佐々木 司, 大城 社子, 田島 みのり, 野口 直哉, 劉 一, 阿部 倫明, Shervani Nausheen J, 高沢 伸, 白土 邦男, 岡本 宏

    生化学　71　(8)　900-900　1999/08

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

  244. 糖尿病患者における抗REG I自己抗体の存在

    高沢 伸, Shervani Nausheen Jamal, 小林 誠一, 田島 みのり, 秋山 貴子, 阿部 倫明, 中沢 哲也, 那谷 耕司, 佐藤 譲, 豊田 隆謙

    糖尿病　42　(Suppl.1)　S111-S111　1999/04

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

    eISSN： 1881-588X

  245. 新しいReg遺伝子(Reg III δ)の発現 その構造決定とマウスRegファミリーの遺伝子地図の作製

    阿部 倫明, 那谷 耕司, 熊谷 智子, 小林 誠一, 秋山 貴子, 野口 直哉, 東郷 暁, 黒木 実智雄, 高沢 伸, 伊藤 貞嘉

    糖尿病　42　(Suppl.1)　S163-S163　1999/04

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

    eISSN： 1881-588X

  246. 【分子高血圧 最新の進歩】15-deoxy-Δ12,14-プロスタグランジンJ2及びトログリタゾンによるトロンボキサン受容体遺伝子の負の転写調節

    菅原 明, 竹内 和久, 宇留野 晃, 池田 勧夫, 工藤 正孝, 谷山 佳弘, 高橋 信行, 阿部 倫明, 伊藤 貞嘉

    血圧　6　(3)　213-215　1999/03

    Publisher: (株)先端医学社

    ISSN： 1340-4598

    More details Close

    15-deoxy-Δ12,14-PGJ2はTXR mRNAの発現を抑制し,トログリタゾンと同様TXR遺伝子プロモーター活性を低下させたことから,これらがTXR遺伝子を転写レベルで抑制しているものと考えられた.TXRの発現抑制は,高血圧や動脈硬化の進展抑制に関与している可能性が推定された

  247. Autoantibody against REG I protein in NIDDM patients

    H Okamoto, S Takasawa, NJ Shervani, S Kobayashi, M Tajima, T Akiyama, M Abe, K Nata, J Satoh, T Toyota

    DIABETES　48　A444-A444　1999

    ISSN： 0012-1797

  248. 新しいマウスReg遺伝子の単離とReg遺伝子ファミリーの遺伝子地図の作製

    阿部 倫明, 那谷 耕司, 熊谷 智子, 松崎 理子, 小林 誠一, 秋山 貴子, 高沢 伸, 伊藤 貞嘉, 岡本 宏

    生化学　70　(8)　811-811　1998/08

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

    eISSN： 2189-0544

  249. 膵β細胞の再生増殖 Reg Iトランスジェニック,ノックアウトマウスを用いた解析

    熊谷 智子, 阿部 倫明, 那谷 耕司, 海野 倫明, 成島 陽一, 加藤 一郎, 小林 誠一, 秋山 貴子, 高沢 伸, 松野 正紀

    生化学　70　(8)　900-900　1998/08

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

    eISSN： 2189-0544

  250. 膵ランゲルハンス島β細胞増殖因子Reg Iの発現誘導機構

    秋山 貴子, 小林 誠一, 那谷 耕司, 熊谷 智子, 阿部 倫明, 松崎 理子, 高沢 伸, 岡本 宏

    生化学　70　(8)　900-900　1998/08

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

    eISSN： 2189-0544

  251. 【高血圧と腎障害】高血圧における腎微小循環

    伊藤 貞嘉, 阿部 倫明

    血圧　5　(5)　508-512　1998/05

    Publisher: (株)先端医学社

    ISSN： 1340-4598

  252. Possible role of P-450 metabolite of arachidonic acid in vasodilator mechanism of angiotensin II type 2 receptor in the isolated microperfused rabbit afferent arteriole

    S Arima, Y Endo, H Yaoita, K Omata, S Ogawa, K Tsunoda, M Abe, K Takeuchi, K Abe, S Ito

    JOURNAL OF CLINICAL INVESTIGATION　100　(11)　2816-2823　1997/12

    ISSN： 0021-9738

    eISSN： 1558-8238

  253. 透析患者の血圧管理の実際 生理的血圧維持機構

    阿部 倫明, 伊藤 貞嘉

    臨床透析　13　(10)　1325-1333　1997/09

    Publisher: (株)日本メディカルセンター

    ISSN： 0910-5808

  254. 高血圧症成因論

    阿部 圭志, 阿部 倫明, 伊藤 貞嘉

    日本臨床　55　(8)　1889-1894　1997/08

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  255. Pathogenesis of hypertension

    K. Abe, M. Abe, S. Ito

    Nippon rinsho. Japanese journal of clinical medicine　55　(8)　1889-1894　1997

    ISSN： 0047-1852

  256. 血圧症成因論 Invited

    阿部圭志, 阿部倫明, 伊藤貞嘉

    日本臨牀　55　1889-1894　1997

Show all ︎Show first 5

Books and Other Publications 5

  1. 専門医のための循環器病学 [監修; 小川聡，井上博，筒井裕]

    阿部倫明, 伊藤貞嘉

    医学書院　2014

  2. 日本大震災を分析する2 震災と人間・まち・記録 [編集; 平川 新, 今村 文彦, 東北大学災害科学国際研究所]

    清元秀泰, 阿部倫明

    明石書店　2013

  3. 腎動脈ステント留置術ハンドブック.[監修]横井宏佳

    阿部倫明, 田熊淑男

    診断と治療社　2011

  4. 薬局 病気と薬パーフェクトブック2010 (増刊号)［監修・編纂］横田千津子・池田宇一・大越教夫

    阿部 倫明

    南山堂　2010

  5. 薬局 病気と薬パーフェクトブック(増刊号)

    阿部倫明

    南山堂　2008/06

Presentations 51

  1. 両側腎動脈狭窄症と水腎症・大動脈周囲炎が合併した急性腎不全の1例

    阿部倫明, 後藤靖雄, 田熊淑男, 佐藤寿伸

    日本腎臓学会東部会　2011/10/14

  2. 腎動脈狭窄症による末期腎不全に対する腎動脈拡張術の可能性

    阿部倫明, 大江佑治, 田熊淑男, 佐藤寿伸

    日本透析医学会　2011/06/17

  3. 長期／大量のRAS系阻害薬投与後にJG細胞の増生が認められたIgA腎症の１例

    阿部倫明, 堀田修, 家入伯夫, 佐藤光博, 木村朋由, 城謙輔, 北村洋, 田熊淑男, 佐藤寿伸

    日本腎臓学会総会　2011/06/15

  4. 経皮経管腎動脈拡張術・ステント留置術中に血栓吸引術を行った腎血管性高血圧症の１例

    相馬友和, 秋山泰利, 豊原敬文, 鈴木健弘, 阿部倫明, 種本雅之, 伊藤貞嘉, 阿部高明

    第187回 内科学会東北地方会　2009/10/20

  5. プレクリニカルクッシング病と副腎コルチゾル産生腫瘍の合併が考えられた１例

    秋山泰利, 相馬友和, 豊原敬文, 鈴木健弘, 阿部倫明, 種本雅之, 阿部高明, 伊藤貞嘉

    第185回 内科学会東北地方会　2009/06/21

  6. 下肢痺れを主訴に診断された腹部大動脈切迫破裂の１例

    岩倉芳倫, 鈴木健弘, 阿部倫明, 種本雅之, 阿部高明, 伊藤貞嘉

    第187回 内科学会東北地方会　2009/02/21

  7. メサンギウム細胞における高グルコース暴露がアンジオテンシンII刺激による酸化ストレス産生を増強させる機序について

    阿部倫明, 宮沢紀子, 豊原敬文, 相馬友和, 秋山泰利, 鈴木健弘, 塩飽浩美, 種本雅之, 阿部高明, 伊藤貞嘉

    第12回 日本心血管内分泌代謝学会学術総会　2008/11/28

  8. 腎動脈起始部の腫瘤性病変により腎血管性高血圧を呈したと考えられる一例

    秋山泰利, 相馬友和, 豊原敬文, 鈴木健弘, 阿部倫明, 種本雅之, 阿部高明, 伊藤貞嘉

    第38回 日本腎臓学会東部学術総会　2008/10/11

  9. RAS阻害およびPTRAにてネフローゼ域蛋白尿からの著明な改善を得た腎血管性高血圧の一例

    相馬友和, 閻 国珊, 秋山泰利, 豊原敬文, 鈴木健弘, 阿部倫明, 種本雅之, 阿部高明, 伊藤貞嘉

    第38回 日本腎臓学会東部学術総会　2008/10/11

  10. 横紋筋融解症を合併した甘草による偽性アルドステロン症の一例

    豊原敬文, 宇留野晃, 秋山泰利, 相馬友和, 鈴木健弘, 阿部倫明, 種本雅之, 阿部高明, 伊藤貞嘉

    第38回 日本腎臓学会東部学術総会　2008/10/11

  11. 高グルコースによるアンジオテンシンII刺激後NAD(P)Hオキシダーゼ活性化の増強調節機序について

    阿部倫明, 宮沢紀子, 豊原敬文, 相馬友和, 秋山泰利, 鈴木健弘, 塩飽浩美, 種本雅之, 阿部高明, 伊藤貞嘉

    第31回 日本高血圧学会総会　2008/10/09

  12. プラバスタチンは有機アニオントランスポーターを介して膵β細胞からのインスリン分泌を刺激する

    鈴木健弘, 阿部倫明, 豊原敬文, 石井晶子, 野口直哉, 秋山泰利, 相馬友和, 塩飽浩美, 種本雅之, 伊藤貞嘉, 阿部高明

    第31回 日本高血圧学会総会　2008/10/09

  13. 妊娠高血圧症候群８症例における血中エンドグリン濃度の検討

    秋山泰利, 相馬友和, 豊原敬文, 鈴木健弘, 阿部倫明, 種本雅之, 阿部高明, 伊藤貞嘉

    第31回 日本高血圧学会総会　2008/10/09

  14. 褐色細胞腫および傍神経節腫の診断における随時尿メタネフリン分画・クレアチニン比の有用性について

    相馬友和, 秋山泰利, 豊原敬文, 鈴木健弘, 阿部倫明, 種本雅之, 阿部高明, 伊藤貞嘉

    第31回 日本高血圧学会総会　2008/10/09

  15. 生理的レベルの副腎皮質刺激が副腎静脈サンプリングの診断に及ぼす影響

    種本雅之, 秋山泰利, 相馬友和, 鈴木健弘, 阿部倫明, 阿部高明, 伊藤貞嘉

    第31回 日本高血圧学会総会　2008/10/09

  16. 筋緊張性ジストロフィーと褐色細胞腫の再発・転移の合併した１例

    川上 徹, 阿部倫明, 相馬友和, 鈴木健弘, 種本雅之, 阿部高明, 伊藤貞嘉

    第186回 内科学会東北地方会　2008/09/20

  17. プレクリニカルクッシング病と副腎コルチゾル産生腫瘍の合併が考えられた１例

    秋山泰利, 相馬友和, 豊原敬文, 鈴木健弘, 阿部倫明, 種本雅之, 阿部高明, 伊藤貞嘉

    第185回 内科学会東北地方会　2008/06/21

  18. 腎動脈狭窄症の狭窄部圧格差と血行再建術の治療効果の関連

    種本雅之, 秋山泰利, 相馬友和, 阿部倫明, 阿部高明, 伊藤貞嘉

    第51回 日本腎臓学会学術総会　2008/05/30

  19. 副腎静脈サンプリングにおける極低量ACTH刺激の有用性

    種本雅之, 相馬友和, 阿部倫明, 阿部高明, 伊藤貞嘉

    第81回日本内分泌学会学術総会　2008/05/16

  20. 褐色細胞腫および傍神経節腫への非イオン性ヨード造影剤使用に伴う合併症の検討

    相馬友和, 秋山泰利, 豊原敬文, 鈴木健弘, 阿部倫明, 種本雅之, 阿部高明, 伊藤貞嘉

    第81回日本内分泌学会学術総会　2008/05/16

  21. 近位尿細管特異的GFP-tTA発現マウスの作製と解析

    豊原敬文, 鈴木健弘, 阿部倫明, 秋山泰利, 種本雅之, 伊藤貞嘉, 阿部高明

    第11回日本心血管内分泌代謝学会　2007/11/16

  22. 経皮経管腎動脈拡張術後の再狭窄がロサルタン内服後の正常血圧の維持により改善した一例

    秋山泰利, 種本雅之, 豊原敬文, 鈴木健弘, 阿部倫明, 阿部高明, 伊藤貞嘉

    第11回日本心血管内分泌代謝学会　2007/11/16

  23. Pravastatinは有機アニオントランスポーターを介してβ細胞からのインスリン分泌を刺激する

    阿部倫明, 豊原敬文, 鈴木健弘, 秋山泰利, 種本雅之, 伊藤貞嘉, 阿部高明

    第11回日本心血管内分泌代謝学会　2007/11/16

  24. アンジオテンシン？とブドウ糖は異なる様式でメザンギウム細胞の酸化ストレスを産生させた

    阿部倫明, 宮澤紀子, 豊原敬文, 中山謙二, 鈴木健弘, 秋山泰利, 塩飽浩美, 種本雅之, 阿部高明, 伊藤貞嘉

    第11回日本心血管内分泌代謝学会　2007/11/16

  25. 超音波パルスドプラ法を用いたARBの腎動脈血流に及ぼす影響

    大平未佳, 藤原淳子, 石塚静江, 佐藤淳子, 渡辺さち子, 阿部倫明, 阿部高明, 賀来満夫

    第30回日本高血圧学会　2007/10/25

  26. メサンギウム細胞におけるアンギオテンシンII負荷と糖負荷による酸化ストレス反応性の相違について

    阿部倫明, 宮澤紀子, 豊原敬文, 中山謙二, 鈴木健弘, 塩飽浩美, 種本雅之, 阿部高明, 伊藤貞嘉

    第30回日本高血圧学会　2007/10/25

  27. 腎尿細管におけるNa負荷によるRedox調節について

    阿部倫明, 伊藤貞嘉

    第30回日本高血圧学会　2007/10/25

  28. High glucose augments AT1R-primed oxidative stress in mesangial cell International-presentation

    Michiaki Abe

    Office of Life Sciences/National University of Singapore – Tohoku University/Centre of Excellence Joint Symposium　2007/09/05

  29. 多発副腎腺腫によるCushing症候群の２例

    秋山泰利, 白田佑子, 小泉賢治, 阿部倫明, 種本雅之, 阿部高明, 伊藤貞嘉, 渡辺みか, 笹野公伸, 荒井陽一

    第183回日本内科学会東北地方会　2007/09/01

  30. センノシドによる消化管吸収不良が原因と考えられた低Ｋ血症の１例

    細山勝寛, 白田佑子, 秋山泰利, 小泉賢治, 阿部倫明, 種本雅之, 阿部高明, 伊藤貞嘉

    第183回日本内科学会東北地方会　2007/09/01

  31. 外科治療を施した多発転移を伴う褐色細胞腫再発の１例

    細谷拓真, 上田詩文, 阿部倫明, 種本雅之, 佐藤文俊, 阿部高明, 伊藤貞嘉, 石戸谷滋人, 荒井陽一

    第182回日本内科学会東北地方会　2007/06/16

  32. 腎血管性高血圧の画像診断における狭窄部最小半径の有用性

    種本雅之, 阿部倫明, 宇留野晃, 佐藤文俊, 阿部高明, 伊藤貞嘉

    第80回日本内分泌代謝学会　2007/06/14

  33. 原発性アルドステロン症の多様性ースクリーニング、確定診断におけるレニン・アンジオテンシン系抑制とACTH反応性の意義ー

    佐藤文俊, 森本玲, 宇留野晃, 阿部倫明, 種本雅之, 阿部高明, 荒井陽一, 笹野公伸, 石橋忠司, 伊藤貞嘉

    第80回日本内分泌代謝学会　2007/06/14

  34. 原発性アルドステロン症における副腎静脈サンプリングの手術適応の診断ー左副腎静脈のカテーテル位置の重要性ー

    佐藤文俊, 森本玲, 宇留野晃, 阿部倫明, 種本雅之, 阿部倫明, 荒井陽一, 笹野公伸, 石橋忠司, 伊藤貞嘉

    第80回日本内分泌代謝学会　2007/06/14

  35. Pravastatinは有機アニオントランスポーターを介して膵β細胞からのインスリン分泌を刺激する

    豊原敬文, 阿部倫明, 石井晶子, 塩飽浩美, 鈴木健弘, 柴田英介, 種本雅之, 伊藤貞嘉, 阿部高明

    第80回日本内分泌代謝学会　2007/06/14

  36. 狭窄部最小径の腎血管性高血圧の治療指標としての有用性

    種本雅之, 宇留野晃, 阿部倫明, 佐藤文俊, 阿部高明, 伊藤貞嘉

    第50回日本腎臓学会　2007/05/25

  37. 近位尿細管特異的遺伝子調節マウスの作製と解析

    豊原敬文, 鈴木健弘, 阿部倫明, 種本雅之, 柴田英介, 進藤智彦, 島 彦仁, 伊藤貞嘉, 阿部高明

    第50回日本腎臓学会　2007/05/25

  38. Renal Echo : What is New ?

    Michiaki Abe

    JPIC 2007　2007/01/26

  39. Abdominal Aortic Aneurysm,Renal Mesenteric and Hemodizlysis Access

    Michiaki Abe

    JPIC2007　2007/01/26

  40. Renal disease-diagnosis and treatment-

    Michiaki Abe

    JPIC2007　2007/01/26

  41. 腎動脈エコーが腎血管性高血圧の診断に有用であった３症例

    豊原敬文, 宇留野晃, 阿部倫明, 種本雅之, 佐藤文俊, 阿部高明, 竹内和久, 伊藤貞嘉

    第36回日本腎臓学会東部学術大会　2006/11/03

  42. Chronic or Acute interaction of angiotensin？on oxdative stress production by glucose pretreated mesangical cells. International-presentation

    Noriko Miyazawa, Michiaki Abe, Takafumi Toyohara, Takehiro Suzuki, Kenji Nakayama, Akiko Ishii, Hiromi Shiwaku, Eisuke Shibata, Masayuki Tanemoto, Fumitoshi Satoh, Takaaki Abe, Sadayoshi Ito

    The 21st Scientific Meeting of the International Society of Hypertension.　2006/10/15

  43. Therapeautic intervemtion of morning hypertension by the angiotensin？receptor blocker Olmesartan -clinical implication of the reduction of albuminuria for the prevention of brain and heart disease. International-presentation

    Fumitoshi Satoh, Ryo Morimoto, Akira Uruno, Michiaki Abe, Masayuki Tanemoto, Takaaki Abe, Sadayoshi Ito

    The 21st Scientific Meeting of the International Society　2006/10/15

  44. Effect of Sarpogrelate hydrochloride on metabolic funcion International-presentation

    Michiaki Abe, Akiko Ishii, Takehiro Suzuki, Takafumi Toyohara, Hiromi Shiwaku, Ryo Morimoto, Tatsuji Chaki, Masayuki Tanemoto, Fumitoshi Satoh, Toshiaki Abe, Sadayoshi Ito, Takaaki Abe

    The 21st Scientific Meeting of the International Society of Hypertension　2006/10/15

  45. Benefical effects of pitavestatin on serum lipids and inflammatory mediators in the treatment of hypertensive, hypercholesterolemic patients International-presentation

    Fumitoshi Satoh, Ryo Morimoto, Akira Uruno, Michiaki Abe, Masayuki Tanemoto, Takaaki Abe, Sadayoshi Ito

    The 21st Scientific Meeting of the International Society of Hypertnsion　2006/10/15

  46. 塩酸サルポグレラートによる糖尿病性腎症の改善効果

    阿部倫明, 鈴木健弘, 石井晶子, 豊原敬文, 塩飽浩美, 森本玲, 茶木辰治, 種本雅之, 佐藤文俊, 竹島浩, 阿部俊明, 伊藤貞嘉, 阿部高明

    第49回日本腎臓学会学術総会　2006/06/14

  47. メサンジウム細胞におけるアンジオテンシン？とグルコースの共依存的活性酸素合成について

    宮沢紀子, 阿部倫明, 中山謙二, 豊原敬文, 鈴木健弘, 種本雅之, 佐藤文俊, 阿部高明, 伊藤貞嘉

    第49回日本腎臓学会学術総会　2006/06/14

  48. 原発性アルドステロン症からみたアルドステロンの臓器障害作用

    佐藤文俊, 中村匡宏, 森本玲, 種本雅之, 阿部倫明, 宇留野晃, 荒井陽一, 笹野公伸, 石橋忠司, 阿部高明, 伊藤貞嘉

    第79回日本内分泌学会学術総会　2006/05/19

  49. 塩酸サルポグレラートによる代謝作用の検討

    阿部倫明, 鈴木健弘, 石井晶子, 豊原敬文, 塩飽浩美, 森本玲, 茶木辰治, 種本雅之, 佐藤文俊, 竹島浩, 阿部俊明, 伊藤貞嘉, 阿部高明

    第79回日本内分泌学会学術総会　2006/05/19

  50. 甲状腺ホルモントランスポーター遺伝子群の単離と機能解析

    鈴木健弘, 三日市剛, 茶木辰治, 森本玲, 豊原敬文, 阿部倫明, 佐藤文俊, 種本雅之, 阿部高明, 伊藤貞嘉

    第79回日本内分泌学会学術総会　2006/05/19

  51. ドップラー超音波が診断、治療の評価に有用であった両側腎動脈狭窄の１例

    豊原敬文, 宇留野晃, 阿部倫明, 種本雅之, 佐藤文俊, 阿部高明, 竹内和久, 伊藤貞嘉

    第178回日本内科学会東北地方会　2006/02/18

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Research Projects 11

  1. クエン酸塩による腎臓病の予防

    阿部 倫明

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2022/04/01 - 2025/03/31

  2. 慢性腎臓病における代謝性アシドーシスの治療介入がもたらす腎保護機序の解明 Competitive

    阿部 倫明

    Offer Organization: 文部科学省科学研究費補助金

    System: 基盤研究(Ｃ)一般

    2016/04 - 2020/03

  3. GATA factor-mediated maintenance of renal function

    MORIGUCHI Takashi, MORITO Naoki, ABE Michiaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    2012/04/01 - 2016/03/31

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    We demonstrated that zinc finger transcription factors,i.e., GATA2 and GATA3 is specifically expressed in renal collecting duct cells and glomerular mesangial cells, respectively. GATA3 plays a critical role for maintenance of the glomerular mesangial cells. Hence, GATA3-deficiency led to the occurence of spontaneous glomerulonephritis. GATA2 regulates a series of genes involved in water-reabsorption. Therefore, renal tubular cell-specific GATA2-deficient mice exhibited higher amount of urine. GATA2 also participates in the regulation of induced expression of inflammatory cytokine genes in the diseased kidney. The renal tubular cell-specific GATA2-deficient mice showed reduced expression level of the inflammatory cytokine genes and resistance against acute kidney injury. Furthermore, a newly identified GATA-inhibitor nicely ameliorated renal damages in the diseased kidney. Collectively, we propose that GATA2 can be a potential therapeutic target for the inflammatory kidney diseases.

  4. 腎移植実験による酸化ストレス脆弱性に起因する腎臓病の治療効果の検証 Competitive

    阿部 倫明

    Offer Organization: 文部科学省科学研究費補助金

    System: 基盤研究(Ｃ)一般

    2013/04 - 2016/03

  5. 腎尿細管液の酸性化とアルブミン尿による腎障害機序の解明と新規腎臓病治療戦略の開発 Competitive

    阿部 倫明

    Offer Organization: 文部科学省科学研究費補助金

    System: 基盤研究(Ｃ)一般

    2010/04 - 2013/03

  6. Mechanisms of cardiovascular-renal connection on life-style diseases

    ITO Sadayoshi, MORI Takefumi, ABE Michiaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2009 - 2011

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    Present study determined the mechanisms of cardiovascular renal injury in CKD and the role of MG. 1%MG in drinking water was administered to Dahl salt sensitive rats exhibited increase in blood pressure associated with cardiovascular-renal injury. Cerebrovascular renal injury was observed in high salt fed stroke-prone spontaneously hypertensive rats, which was associated with blood pressure and oxidative stress. Glucose induced mitochondrial oxidative stress was observed in the tubules of juxtamedullary nephron, which was inhibited in glyoxalase 1 trangenic rats, indicating that carbonyl stress is responsible for glucose mediated renal injury

  7. ヒト大動脈培養細胞におけるメチルグリオキサールによる酸化ストレス産生機序について Competitive

    阿部 倫明

    Offer Organization: 応用酵素協会

    System: 研究助成

    2009 -

  8. 液性刺激と機械的刺激による細胞内フリーラジカル産生機序の詳細な解明 Competitive

    阿部 倫明

    Offer Organization: 文部科学省科学研究費補助金

    System: 若手研究（Ｂ）

    2006/04 - 2008/03

  9. メサンギウム細胞の酸化ストレスを産生におけるアンギオテンシンIIとブドウ糖の役割 Competitive

    阿部 倫明

    Offer Organization: 応用酵素協会

    System: 研究助成

    2008 -

  10. 腎尿細管におけるNa負荷によるRedox調節について Competitive

    阿部 倫明

    Offer Organization: 応用酵素協会

    System: 研究助成

    2007 -

  11. プロスタノイドによる傍糸球体装置における血圧調節メカニズムの解明、及び新薬の創製（留学先；ウィスコンシン医科大学・合衆国） Competitive

    阿部 倫明

    Offer Organization: 日本心臓財団

    System: バイエル海外留学助成

    2003 -

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Social Activities 6

  1. [日本国内] 第15回仙台南循環器カンファランス

    2008/11/25 -

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    腎動脈エコーから見た腎血管性高血圧と虚血性腎症

  2. [日本国内] 高血圧フォーラム in 仙台

    2008/09/18 -

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    腎動脈狭窄症・腎血管性高血圧と腎動脈エコーについて

  3. [日本国内] 社外講師勉強会

    2008/07/10 -

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    腎動脈狭窄症・腎血管性高血圧と腎動脈エコーについて

  4. [日本国内] 社外勉強会

    2008/06/13 -

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    腎血管性高血圧症の診断と治療、腎疾患における腎動脈ドップラーエコーの役割

  5. [日本国内] 第１回Japan Endovascular Treatment Conference

    2008/04/11 -

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    腎動脈狭窄症の診断

  6. [日本国内] 第４回 KHES(Kidney,Hypertension&Endocrine Seminar)

    2007/10/16 -

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    ハンプの作用機序と腎保護作用「腎動脈エコーから見た腎動脈狭窄と腎血管性高血圧」

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  1. 高糖状態によるメサンギウム細胞の前暴露はアンジオテンシン？刺激による酸化ストレスを増強させた

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    高糖状態によるメサンギウム細胞の前暴露はアンジオテンシン？刺激による酸化ストレスを増強させた