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Hiroyuki Sakata

Section

Graduate School of Medicine

Job title

Associate Professor

Degree

researchmap

https://researchmap.jp/hiroyukisakata

J-GLOBAL ID

201801005797471062

e-Rad No.

80722305

Research History 12

2025/07 - Present

Tohoku University Graduate School of Medicine　Department of Translational Neuroscience　Associate Professor
2025/01 - 2025/06

Tohoku University Graduate School of Medicine　Department of Neurosurgery　Associate Professor
2023/04 - 2024/12

Kohnan Hospital　Department of Neuroendovascular Therapy　Director
2023/04 - 2024/12

Kohnan Hospital　Department of Neurosurgery　Director
2022/07 - 2023/03

Kohnan Hospital　Department of Neuroendovascular Therapy　Director
2019/04 - 2022/06

National Hospital Organization Sendai Medical Center　Department of Neurosurgery　Medical director
2018/11 - 2019/03

青森県立中央病院　脳神経外科　副部長
2018/04 - 2018/10

白河厚生総合病院　脳神経外科　科長
2016/04 - 2017/03

Tohoku University　Graduate School of Biomedical Engineering
2014/05 - 2016/03

Tohoku University　Graduate School of Medicine
2013/11 - 2014/04

Tohoku University　Graduate School of Medicine
2009/03 - 2011/12

Stanford大学　脳神経外科　研究員

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Education 2

東北大学大学院　医学部　医学系研究科

2008/04 - 2013/03
Tohoku University　Faculty of Medicine　School of Medicine

1999/04 - 2005/03

Committee Memberships 11

日本脳神経外科コングレス　庶務会計副幹事

2025/10 - Present
日本脳循環代謝学会　幹事

2025/10 - Present
日本脳卒中の外科学会　広報委員会

2025/04 - Present
The Japanese Society for Neuroendovascular Therapy　Delegate

2024/09 - Present
The Japan Stroke Society　Delegate

2024/08 - Present
Journal of Neuroendovascular Therapy　Review Board

2024/03 - Present
Neurologia medico-chirurgica　Review Board

2023/12 - Present
日本脳神経外科学会　代議員

2023/09 - Present
Sigma Xi, The Scientific Research Honor Society　Elected Full Member

2023/04 - Present
Frontiers in Stroke　Associate Editor

2021/12 - Present
日本脳循環代謝学会　評議員

2017 - 2025/09

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Professional Memberships 6

日本神経内視鏡学会
THE JAPAN STROKE SOCIETY
THE JAPANESE SOCIETY ON SURGERY FOR CEREBRAL STROKE
日本脳循環代謝学会
日本脳血管内治療学会
THE JAPAN NEUROSURGICAL SOCIETY

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Research Interests 8

Brain tumor
Mechanical thrombectomy
Regenerative medicine
Cerebral Revascularization
Neuroendovascular therapy
脳卒中
cerebrovascular disease
Neurosurgery

Research Areas 1

Life sciences / Neurosurgery /

Awards 2

Progress and Innovation Award

2012　Stoke: Journal of Cerebral Circulation
Young Investigator Award

2011　Brain: International Symposium on Cerebral Blood Flow, Metabolism, and Function

Papers 121

Stratified assessment of clazosentan efficacy following subarachnoid hemorrhage: A multi-center cohort study. International-journal Peer-reviewed

Hiroyuki Sakata, Hiroki Uchida, Atsushi Kanoke, Shunsuke Omodaka, Ryosuke Tashiro, Yoshimichi Sato, Naoto Kimura, Masahiro Yoshida, Kenichi Sato, Kuniyasu Niizuma, Hirohito Metoki, Hidenori Endo

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism　271678X251399068　2025/11/21

DOI： 10.1177/0271678X251399068 　

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There are conflicting results regarding the efficacy of clazosentan, a selective endothelin A receptor antagonist, on cerebral vasospasm after subarachnoid hemorrhage (SAH). As the effectiveness of clazosentan for patients over 75 years old and those with World Federation of Neurosurgical Societies grade V has not been established, we aimed to evaluate its efficacy in real-world clinical settings. This study utilized prospectively collected data from consecutive SAH patients across 4 stroke centers, comparing 187 patients treated with clazosentan to 223 patients receiving standard of care. The incidence of favorable functional outcomes (modified Rankin Scale score 0-2) at 90 days after SAH, occurred more frequently in patients receiving clazosentan (74.9% vs 65.0%, p = 0.032). Multiple logistic analyses identified clazosentan administration as independently associated with favorable functional outcomes (49.1% vs 37.6%, odds ratio 2.17 [1.22-3.85], p = 0.008). Angiographic vasospasm (25.7% vs 48.9%, p < 0.001) and vasospasm-related infarcts (11.8% vs 20.2%, p = 0.023) were less frequent among patients receiving clazosentan. Stratification analyses revealed that clazosentan usage increased the incidence of favorable functional outcomes regardless of age, sex, SAH severity, and clot volume. These results underscore the therapeutic potential of clazosentan against cerebral vasospasm independent of patient characteristics.
Interleukin 6-preconditioned neural stem cells reduce ischaemic injury in stroke mice Peer-reviewed

Hiroyuki Sakata, Purnima Narasimhan, Kuniyasu Niizuma, Carolina M. Maier, Takuma Wakai, Pak H. Chan

BRAIN　135　(Pt 11)　3298-3310　2012/11

DOI： 10.1093/brain/aws259 　

ISSN： 0006-8950
Neural Stem Cells Genetically Modified to Overexpress Cu/Zn-Superoxide Dismutase Enhance Amelioration of Ischemic Stroke in Mice Peer-reviewed

Hiroyuki Sakata, Kuniyasu Niizuma, Takuma Wakai, Purnima Narasimhan, Carolina M. Maier, Pak H. Chan

STROKE　43　(9)　2423-+　2012/09

DOI： 10.1161/STROKEAHA.112.656900 　

ISSN： 0039-2499
Minocycline-Preconditioned Neural Stem Cells Enhance Neuroprotection after Ischemic Stroke in Rats Peer-reviewed

Hiroyuki Sakata, Kuniyasu Niizuma, Hideyuki Yoshioka, Gab Seok Kim, Joo Eun Jung, Masataka Katsu, Purnima Narasimhan, Carolina M. Maier, Yasuhiro Nishiyama, Pak H. Chan

JOURNAL OF NEUROSCIENCE　32　(10)　3462-3473　2012/03

DOI： 10.1523/JNEUROSCI.5686-11.2012 　

ISSN： 0270-6474
Heterogeneity of Clazosentan Benefit after Aneurysmal Subarachnoid Hemorrhage Demonstrated in an Externally Validated Causal Policy Tree. International-journal Peer-reviewed

Kazuki Nishida, Basile Chrétien, Shinsuke Muraoka, Takashi Izumi, Masahiro Nishihori, Shunsaku Goto, Issei Takeuchi, Ryosuke Tashiro, Hiroyuki Sakata, Denis Vivien, Masaaki Mizuno, Hidenori Endo, Ryuta Saito

Neurocritical care　2026/06/17

DOI： 10.1007/s12028-026-02573-5 　

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BACKGROUND: Clazosentan reduces angiographic vasospasm after aneurysmal subarachnoid hemorrhage (aSAH), but functional benefit may vary across patients. We used causal machine learning to explore heterogeneity and derive an interpretable rule. METHODS: In a secondary analysis of the RECOVER dataset [multicenter retrospective cohort of aSAH treated by clipping or coiling within 48 h (N = 506)], we compared clazosentan-containing management (with or without fasudil) with fasudil-only prophylaxis. After applying inverse probability of treatment weighting for prespecified confounders [age, World Federation of Neurosurgical Societies (WFNS) grade, Fisher grade, and body mass index (BMI)], we used a causal forest to estimate conditional average treatment effects (CATEs) on favorable discharge outcome (modified Rankin Scale 0-2 at discharge). A policy tree summarized CATEs, and external validation was performed in an independent cohort (N = 181). RESULTS: CATEs were heterogeneous (mean 0.18 ± 0.14). The policy tree split first on BMI (≤ 20.03 kg/m2): patients with BMI ≤ 20.03 and WFNS ≤ 2 showed no clear estimated benefit (mean CATE - 0.058), whereas those with BMI > 20.03 or WFNS > 2 showed higher estimated benefit (CATE 0.24-0.25). In external validation, the same rule identified a subgroup with higher odds of favorable recovery with clazosentan; estimates in the low-benefit subgroup were imprecise (n = 27). CONCLUSIONS: In observational cohorts with limited overlap in treatment assignment, causal machine learning suggested heterogeneity in the estimated association of a clazosentan-containing strategy with discharge outcomes and produced a simple BMI/WFNS policy tree. These findings are hypothesis-generating and require prospective validation including safety endpoints and longer-term functional outcomes.
Angioarchitecture and classification of adult intracranial pial arteriovenous fistulas: a multicenter study Peer-reviewed

Hiroki Yamada, Yasuyuki Kaku, Katsuhiro Mizutani, Masafumi Hiramatsu, Takashi Izumi, Shuichi Tanoue, Hiro Kiyosue, Takenori Akiyama, _ _, Ko Okada, Keita Suzuki, Tomohiko Ozaki, Satoshi Koizumi, Wataro Tsuruta, Osamu Masuo, Hiroyuki Sakata, Kotaro Tatebayashi, Satoshi Shitara, Toshihiro Yamauchi, Koichi Arimura, Shunya Tanaka, Naoki Kato, Masakazu Okawa, Hisayuki Hosoo, Nobutaka Horie, Daizo Ishii, Hitoshi Fukuda, Kohei Takikawa, Hiroaki Neki, Katsunori Asai, Takayuki Kato, Tsuyoshi Ohta, Ryu Fukumitsu, Tadashi Sunohara, Fumihiro Sakakibara, Naoki Toma, Yume Suzuki, Aiko Terada, Yusuke Nishikawa, Naoki Akioka, Naoya Kidani, Hirotoshi Imamura, Koji Hashimoto, Ryuichi Shimada, Masashi Yoshizawa, Kouichi Misaki, Shinsuke Sato, Naoko Miyamoto, Hidemoto Fujiwara, Hisanori Edaki, Michihiro Tanaka, Ryota Ishibashi, Yuki Matsunaga, Kenichiro Suyama, Masashi Kotsugi

Journal of Neurosurgery　1-11　2026/06/01
Publisher: Journal of Neurosurgery Publishing Group (JNSPG)
DOI： 10.3171/2026.1.jns252436 　

ISSN： 0022-3085

eISSN： 1933-0693

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OBJECTIVE Pial arteriovenous fistulas (AVFs) are rare cerebrovascular shunts characterized by direct connections between pial arteries and veins. Despite increasing recognition in adults, their anatomical features and clinical implications remain poorly understood. The authors aimed to characterize the clinical and radiological features of adult intracranial pial AVFs, propose an angioarchitectural classification, and assess treatment outcomes. METHODS The authors conducted a nationwide, multicenter, retrospective cohort study of adult intracranial pial AVFs in Japan between 2013 and 2024. Imaging data were centrally reviewed to confirm diagnoses and classify lesions based on angioarchitecture. Lesions were defined as microfistulas when the diameter of the shunt feeder was < 2 mm and as macrofistulas when it was ≥ 2 mm. Clinical features, treatment strategies, and outcomes were compared descriptively between the groups. RESULTS A total of 66 patients with 72 pial AVFs were analyzed. Compared with macrofistulas, microfistulas were more common (74.2%) and occurred more often in older patients (median age 66 vs 32 years, p < 0.001). Furthermore, dural AVFs (42.9% vs 5.9%, p = 0.006) and a history of cerebrovascular events (24.5% vs 0%, p = 0.027) were more frequently observed in microfistulas. Varix formation and multiple draining veins were commonly seen in macrofistulas (94.7% vs 7.5%, p < 0.001 and 21.1% vs 0%, p = 0.004, respectively). Among 72 lesions, 70.8% underwent intervention, with transarterial embolization being the most common modality (51.0%). Complete obliteration was achieved in 78.4% of treated cases. Each lesion was further subclassified into distinct subtypes based on angioarchitectural configuration. One macrofistula subtype (5.6%), characterized by multiple feeders connecting to different multiple draining veins, showed lower obliteration rates and higher complication rates in the few treated cases. CONCLUSIONS Adult pial AVFs exhibit considerable angioarchitectural heterogeneity, which may relate to variations in clinical presentation and management. Our proposed classification scheme may provide a descriptive framework for characterizing these lesions, although further validation is needed.
Dual impact of flow diverters on ischemic and hemorrhagic outcomes in vertebral artery dissecting aneurysms presenting with ischemia Peer-reviewed

Yuto Shingai, Hiroyuki Sakata, Shunsuke Omodaka, Tomohisa Ishida, Ryosuke Tashiro, Yoshimichi Sato, Hidenori Endo

Frontiers in Neurology　17　2026/05/08
Publisher: Frontiers Media SA
DOI： 10.3389/fneur.2026.1815552 　

eISSN： 1664-2295

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Introduction Intracranial vertebral artery dissecting aneurysms (VADA) may manifest as ischemic stroke. Although some individuals stabilize with conservative management, aneurysmal enlargement and recurrent embolic events may still occur, especially in partially thrombosed lesions. The role of flow diversion (FD) in ischemia-onset VADA remains unclear. This study reports the first focused experience evaluating FD in VADA with ischemic onset. Methods Among 119 FD procedures performed between 2022 and 2025, four male individuals were treated for ischemia-onset VADA. All lesions were in the V4 segment, and three showed partial thrombosis. FD was selected for aneurysmal enlargement (four individuals) or recurrent infarction (two individuals). Dual antiplatelet therapy was started at least 7 days before the procedure. Results FD placement was technically successful in all cases, with no complications. Six-month angiography showed O’Kelly–Marotta grade C occlusion in all lesions, indicating effective flow remodeling. No individuals experienced recurrent cerebral infarction or aneurysmal rupture. Conclusion Flow diversion may be a feasible treatment option in selected cases of ischemia-onset VADA. It may reduce the risk of recurrent embolic events and aneurysmal rupture.
Intraoperative hemispheric circulation time as a potential predictor of aneurysm occlusion after flow diverter treatment in large internal carotid artery aneurysm Peer-reviewed

Yoshimichi Sato, Hiroyuki Sakata, Kenshi Sano, Atsushi Kanoke, Shunsuke Omodaka, Hidenori Endo

Neurosurgical Review　49　(1)　2026/04/18
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s10143-026-04285-y 　

eISSN： 1437-2320
Safety and effectiveness of clazosentan in patients after aneurysmal subarachnoid haemorrhage: a second interim report of a post-marketing surveillance in Japan Peer-reviewed

Hiroyuki Sakata, Yuya Takayama, Yuna Iwasaki, Hiroyuki Uchida, Satoshi Nishimoto, Osamu Togo

Neurosurgical Review　49　(1)　2026/03/31
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s10143-026-04240-x 　

eISSN： 1437-2320
Association between Pretreatment Circumferential Wall Enhancement and Retreatment Rate in Endovascularly Treated Internal Carotid - Posterior Communicating Artery Aneurysms. International-journal Peer-reviewed

Yun-Ju Shih, Hiroyuki Sakata, Shunsuke Omodaka, Yoshimichi Sato, Kenshi Sano, Hidenori Endo

World neurosurgery　124939-124939　2026/03/27

DOI： 10.1016/j.wneu.2026.124939 　

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OBJECTIVE: Internal carotid-posterior communicating artery (IC-PC) aneurysms have a high recurrence rate after endovascular treatment. Pretreatment MRI vessel wall imaging (VWI) may predict recurrence through aneurysm wall enhancement (AWE) patterns; however, its role in IC-PC aneurysms remains unclear. This study investigated the association between pretreatment VWI findings and retreatment risk in patients with IC-PC aneurysms. METHODS: This single-center retrospective cohort study included 173 patients with IC-PC aneurysms among 1145 intracranial aneurysms (IAs) treated endovascularly from 2016 to 2021. Patients without 1-year follow-up or pretreatment VWI were excluded. The baseline clinical, angiographic, and VWI characteristics were analyzed. AWE was classified into circumferential aneurysm wall enhancement (CAWE), focal enhancement, or negative. The primary outcome was the identification of risk factors for retreatment, as assessed using multivariate logistic regression. RESULTS: Retreatment was more frequent in IC-PC aneurysms than in all IAs (19% vs. 10%, p<0.001). Among IC-PC aneurysms, 141 patients required no retreatment (effective treatment group), and 32 required retreatment. Factors that were significantly different between the effective treatment and retreatment groups included initial presentation (p=0.009), maximum aneurysm diameter (p<0.001), neck width (p<0.001), posterior communicating artery type (p=0.019), and VWI enhancement pattern (p<0.001). Multivariable analysis identified CAWE as the only independent predictor (odds ratio, 28.1; 95% confidence interval, 8.15-90.3; p<0.001). CAWE was observed in 72% of retreatment cases compared with 8.5% of effective treatment cases. CONCLUSIONS: Pretreatment CAWE on VWI is a strong independent predictor of retreatment in IC-PC aneurysms after endovascular treatment.
Calcified nodules in the cervical carotid artery Peer-reviewed

Yoshihiko Morisue, Hiroki Uchida, Fumiyoshi Fujishima, Hirofumi Watanabe, Atsushi Kanoke, Hiroyuki Sakata, Hidenori Endo

Surgical Neurology International　17　82-82　2026/02/13
Publisher: Scientific Scholar
DOI： 10.25259/sni_715_2025 　

ISSN： 2229-5097

eISSN： 2152-7806

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Background: Calcified nodules (CNs) are a distinct morphological subtype of calcified plaques that cause acute coronary events. However, their clinical relevance in carotid artery disease remains poorly understood. Case Description: We report two cases of symptomatic carotid artery stenosis caused by CNs, both successfully treated with carotid endarterectomy (CEA). In both cases, computed tomography angiography (CTA) revealed severely stenotic lesions with bulky calcified plaques protruding into the vascular lumen. Plaque imaging with magnetic resonance imaging and carotid ultrasonography suggested the presence of calcified components. Surgical excision confirmed the diagnosis of CNs through pathological evaluation. Both patients had favorable outcomes with no neurological deficits on discharge. Notably, CNs are rarely reported in the context of carotid artery disease, and preoperative diagnosis remains challenging due to the lack of established imaging criteria. CTA may be a useful non-invasive tool for identifying CNs, as shown in coronary artery studies. Conclusion: These cases demonstrate that CNs can cause severe carotid stenosis requiring CEA. CTA may aid in the preoperative identification of CNs, and when CNs are identified on CTA, CEA should be the preferred treatment over carotid artery stenting. Further studies are warranted to clarify the diagnostic criteria and treatment strategies for CNs in carotid disease.
Minimally invasive treatment strategy combining a partial resection with cyst aspiration and subsequent Gamma Knife radiosurgery for cystic hypoglossal neurinoma in an older adult: illustrative case. International-journal Peer-reviewed

Keigo Mizuno, Ryosuke Tashiro, Shunsuke Omodaka, Tomohisa Ishida, Ryo Kusaka, Rikuto Ito, Hiroyuki Sakata, Hidefumi Jokura, Hidenori Endo

Journal of neurosurgery. Case lessons　11　(6)　2026/02/09

DOI： 10.3171/CASE25821 　

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BACKGROUND: Hypoglossal neurinomas are rare tumors that pose management challenges, particularly when they contain cystic components. While total removal remains the standard treatment, resection can be excessively invasive for older adults. This report describes a case of cystic hypoglossal neurinoma successfully treated through a partial resection with cyst aspiration followed by Gamma Knife radiosurgery (GKRS). OBSERVATIONS: A male aged 81 years presented with progressive dysarthria and dysphagia secondary to left hypoglossal nerve palsy. MRI revealed a cystic lesion compressing the medulla and a solid component within the left hypoglossal canal. Cyst aspiration was performed to alleviate potentially life-threatening lower cranial nerve palsy, followed by GKRS. At 21 months, marked cyst shrinkage was observed after a transient post-GKRS expansion, with no further interventions required. LESSONS: A treatment strategy combining cyst aspiration and GKRS was useful for managing cystic hypoglossal neurinoma in an older adult. Minimally invasive management should be considered for older adults with comorbidities who are at increased risk for postoperative complications. https://thejns.org/doi/10.3171/CASE25821.
Optimal strategy for mechanical thrombectomy based on the preoperative imaging features of the thrombus. International-journal Peer-reviewed

Hiroyuki Sakata, Masayuki Ezura, Ryosuke Tashiro, Shunsuke Omodaka, Kenichi Sato, Kuniyasu Niizuma, Hidenori Endo

Clinical neurology and neurosurgery　263　109322-109322　2026/01/18

DOI： 10.1016/j.clineuro.2026.109322 　

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OBJECTIVE: Successful recanalization is not achieved in approximately 20 % of stroke patients who underwent mechanical thrombectomy, possibly due to the characteristics of the underlying thrombus. This study aimed to identify the most appropriate thrombectomy strategy based on the preoperative imaging features of the thrombus. METHODS: We retrospectively evaluated the data of 70 patients who underwent mechanical thrombectomy. Thrombus density was assessed using non-contrast computed tomography (ΔCT values) and CT angiography (thrombus permeability). Difficult-to-retrieve thrombi were categorized based on the cutoff values (ΔCT <10 Hounsfield units and/or thrombus permeability <9 Hounsfield units). Favorable outcomes (modified Rankin scale score of 0-2) and successful recanalization (Thrombolysis in Cerebral Infarction grade 2b or 3) were evaluated. We also analyzed the interaction between thrombus imaging features and thrombectomy strategy (stent retriever (SR) alone vs. combined strategy) and its effect on recanalization. RESULTS: Patients with favorable outcomes and successful recanalization had statistically higher ΔCT values and thrombus permeability. Multiple logistic analyses identified difficult-to-retrieve thrombi as independently associated with fewer favorable outcome (odds ratio: 0.12 [0.03-0.36], p < 0.001). The combined strategy demonstrated significantly greater effectiveness in achieving successful recanalization for difficult-to-retrieve thrombi compared with the SR-alone strategy (84.2 % vs. 50 %, odds ratio: 5.33, 95 % CI: 1.14-24.90, p = 0.038). However, normal thrombi demonstrated comparable responses with both strategies (92.3 % vs. 100 %, p = 0.394). CONCLUSION: Given its procedural simplicity and cost-effectiveness, the SR-alone strategy may be effective for normal thrombi, whereas the combined strategy may be preferable for difficult-to-retrieve thrombi.
Intraoperative Near-infrared Spectroscopy Findings Reflecting Cerebrovascular Autoregulation during Staged Angioplasty for Severe Carotid Artery Stenosis: A Case Report.

Norihiro Iwamoto, Shin-Ichiro Osawa, Norio Narita, Hiroyuki Sakata, Hidenori Endo

NMC case report journal　13　347-353　2026

DOI： 10.2176/jns-nmc.2025-0403 　

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Cerebral hyperperfusion syndrome is a potentially life-threatening complication following carotid artery stenting, particularly in patients with impaired cerebrovascular autoregulation. Staged angioplasty has been proposed to reduce this risk by gradually restoring blood flow and promoting recovery of autoregulatory function. However, it remains unclear how autoregulation responds intraoperatively during each stage of staged angioplasty. We report a case of a 79-year-old man with progressive ischemic stroke caused by severe stenosis of the right internal carotid artery. Preoperative cerebral blood flow was reduced in the right hemisphere. Three months after stroke onset, first-stage percutaneous transluminal angioplasty was performed under near-infrared spectroscopy monitoring. Following balloon dilatation, the minimal lumen diameter increased from 0.4 mm to 1.0 mm, and a marked increase in regional cerebral oxygen saturation on the affected side prompted termination of further dilation. Postoperative imaging showed improved perfusion without signs of cerebral hyperperfusion syndrome. Nineteen days later, definitive carotid artery stenting was performed. Although the lumen diameter increased by 2.7 mm during the stenting procedure, there was no sustained increase in regional cerebral oxygen saturation, and no hyperperfusion or neurological symptoms developed. These contrasting intraoperative responses suggested that cerebral autoregulation was impaired before the first-stage percutaneous transluminal angioplasty procedure but had recovered by the time of the second. This case highlights the potential value of real-time near-infrared spectroscopy monitoring in assessing cerebral autoregulation and guiding intraoperative decision-making during staged angioplasty. Timely identification of hyperperfusion risk using this approach may improve the safety of carotid interventions, particularly in high-risk patients with compromised hemodynamic reserve.
Seizure-Induced Transient Early Venous Visualization on Angiography in Glioblastoma: A Case Report Peer-reviewed

Daiki Aburakawa, Atsushi Kanoke, Hiroki Uchida, Hiroyuki Sakata, Hidenori Endo

Journal of Neuroendovascular Therapy　20　(1)　n/a-n/a　2026
Publisher: The Japanese Society for Neuroendovascular Therapy
DOI： 10.5797/jnet.cr.2025-0164 　

ISSN： 1882-4072

eISSN： 2186-2494
出血発症AVM急性期治療における血管内治療の役割

面高俊介, 鹿毛淳史, 坂田洋之, 遠藤英徳

Neurosurgical Emergency　30　(3)　2026

ISSN： 1342-6214
[Paradigm Shift in Intracranial Aneurysm Management: Clinical Application of Flow Diverters in Japan]. Invited

Hiroyuki Sakata, Hidenori Endo

No shinkei geka. Neurological surgery　54　(1)　63-71　2026/01

DOI： 10.11477/mf.030126030540010063 　

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Endovascular treatment of large, wide-necked intracranial aneurysms has been challenged by high recurrence rates following coil embolization. Flow diverters, designed to redirect blood flow away from the aneurysm sac and promote thrombosis and vessel wall reconstruction, have transformed therapeutic strategies. These devices, characterized by high mesh density compared to conventional stents, have become cornerstones in aneurysm management. Since the approval of the Pipeline device in 2008, multiple flow diverters have been developed worldwide; clinical use in Japan began in 2015, with expanded indications after 2020. Currently, Pipeline Flex with Shield Technology, FRED X, and Surpass Evolve are available domestically, each with distinct structural features, deployment characteristics, and antithrombotic properties. This article provides an overview of their differences, focusing on device selection, deployment techniques, and clinical applicability. By integrating device-specific considerations with structured preoperative planning, flow-diverter therapy offers a paradigm shift in treating complex aneurysms, thereby expanding options for cases resistant to conventional interventions.
Functional Assessment of Cerebrovascular Dynamics Through Continuous Intracranial Arterial Pressure Waveform Analysis. International-journal Peer-reviewed

Ryuzaburo Kochi, Eishi Asano, Yoshiteru Shimoda, Atsushi Kanoke, Shunsuke Omodaka, Hiroyuki Sakata, Kanako Sato, Yasuhiro Suzuki, Yasushi Matsumoto, Kuniyasu Niizuma, Hidenori Endo

World neurosurgery　207　124746-124746　2025/12/18

DOI： 10.1016/j.wneu.2025.124746 　
Endoscope-integrated indocyanine green videoangiography for craniocervical dural arteriovenous fistula with ruptured anterior spinal artery aneurysm: a case report and review of the literature. International-journal Peer-reviewed

Tomohisa Ishida, Tomohiro Kawaguchi, Hiroyuki Sakata, Hidenori Endo

Journal of medical case reports　19　(1)　583-583　2025/11/17

DOI： 10.1186/s13256-025-05575-7 　

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BACKGROUND: Treatment for arteriovenous fistulas located at the craniocervical junction involving the pial feeder aneurysm is challenging. When a direct aneurysm manipulation is not feasible, shunt interception to achieve flow reduction is a considerable option. However, a potential risk for remnant or recurrence of aneurysm may exist due to residual minor shunt flow from small vessels that are undetectable using conventional digital subtraction angiography. CASE PRESENTATION: A 44-year-old Asian man presented with sudden-onset left occipital headache, right thermoanesthesia, and left hemiparesis due to hematomyelia of the cervical spine. Digital subtraction angiography revealed epidural arteriovenous fistula with aneurysmal formation on the anterior spinal artery. As a direct approach to the aneurysm was difficult, the anterior spinal artery was intercepted from the fistula. During surgery, an endoscope-integrated indocyanine green videoangiography allows a clear visualization of abnormal small vessels that were not fully evaluated using digital subtraction angiography. Although the aneurysm blood flow was remnant, shunt interception was confirmed through endoscopic findings of disappearance of blood flow to these small vessels, leading to subsequent aneurysm obliteration. CONCLUSION: In the treatment of dural arteriovenous fistulas with anterior spinal artery aneurysm, a more precise assessment of small vessels and their occlusion is possible through the use of an endoscope-integrated indocyanine green videoangiography.
Novel Use of Intracranial Arterial Pressure Waveforms to Detect Occlusive Events During Neuroendovascular Treatment Peer-reviewed

Ryuzaburo Kochi, Eishi Asano, Yoshiteru Shimoda, Atsushi Kanoke, Shunsuke Omodaka, Hiroyuki Sakata, Kanako Sato, Yasuhiro Suzuki, Yasushi Matsumoto, Kuniyasu Niizuma, Hidenori Endo

STROKE-VASCULAR AND INTERVENTIONAL NEUROLOGY　5　(6)　2025/11

DOI： 10.1161/SVIN.125.001946 　

ISSN： 2694-5746
Repeated recurrence after endovascular treatment for cerebral aneurysms: predictive clinical factors and optimal therapeutic management. International-journal Peer-reviewed

Kota Kurisu, Hiroyuki Sakata, Yasushi Matsumoto, Atsushi Kanoke, Shunsuke Omodaka, Miki Fujimura, Hidenori Endo

Neurosurgical review　48　(1)　603-603　2025/08/16

DOI： 10.1007/s10143-025-03758-w 　

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Despite significant advances in endovascular treatment (EVT) of cerebral aneurysms, post-treatment recurrence necessitating multiple retreatments remains a severe concern. Herein, we investigated the clinical characteristics of aneurysms necessitating multiple retreatments after EVT (refractory aneurysms: R-ANs) and explored appropriate management strategies. This retrospective cohort study enrolled 1,045 aneurysms initially treated with EVT between 2016 and 2022. R-ANs were defined as cases requiring two or more retreatment sessions due to repeated recurrence or regrowth. Clinical data were retrospectively reviewed, and predictive factors were identified. Furthermore, the treatments performed and clinical outcomes were investigated. Of 1,045 aneurysms, 101 (9.7%) exhibited recurrence or regrowth requiring retreatment. Among these, 23 aneurysms (2.2%) requiring two or more retreatment sessions, which were classified as R-ANs. As for the predictive factors of R-AN development, large size (> 10 mm), and circumferential aneurysmal wall enhancement on vessel wall imaging (VWI) were identified as relevant and independent predictive factors, with odds ratios of 3.92 (95% CI, 1.36- 11.62), 8.02 (95% CI, 2.02- 53.6), respectively. In terms of therapeutic outcomes, repeat EVT sessions provided favorable long-term clinical outcomes (aneurysm stabilization, 85.0%; favorable occlusion, 65.0%) and low periprocedural complication rates (2.6%). This study identified the relevant predictive factors for R-AN development, suggesting that careful follow-up is essential in patients with these factors. Furthermore, repeated EVT sessions appears to be a safe and efficient treatment strategy for such challenging cases.
くも膜下出血術後管理におけるクラゾセンタンのリアルワールドデータ

遠藤英徳, 坂田洋之, 鹿毛淳史, 内田浩喜, 面高俊介, 新妻邦泰

くも膜下出血と脳血管攣縮　39-40　81-81　2025/06
Publisher: SAH
ISSN： 2759-2405
Decreased Lactococcus lactis and propionic acid in feces of patients with Moyamoya disease: Possible implications of immune dysregulation. International-journal Peer-reviewed

Mayuko Otomo, Ryosuke Tashiro, Hidetaka Tokuno, Atsushi Kanoke, Keita Tominaga, Arata Nagai, Takashi Aikawa, Daisuke Ando, Hiroyuki Sakata, Takeya Sato, Takaaki Abe, Hidenori Endo, Kuniyasu Niizuma, Teiji Tominaga

Cerebrovascular diseases (Basel, Switzerland)　1-15　2025/03/26

DOI： 10.1159/000545478 　

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INTRODUCTION: Moyamoya disease (MMD) is a cerebrovascular disease characterized by progressive steno-occlusive lesions in the terminal portion of the internal carotid artery. Despite its unknown etiology, immune dysregulation is regarded as a critical trigger for delineating the pathophysiology of MMD. The gut microbiota produces short-chain fatty (SCFA) and organic acids, influencing immune regulation and vascular remodeling. We aimed to characterize the gut microbiota in patients with MMD. METHODS: Sixteen patients with MMD and sixteen healthy controls were included in this study. We performed 16S rRNA sequencing of fecal samples and analyzed microbiome diversity and composition, and quantified SCFA and organic acid levels using liquid chromatography. RESULTS: There were no significant differences in α- and b-diversities among feces from the MMD patients and controls. However, 16S rRNA sequencing identified defective Lactococcus lactis (0 ± 0 in the MMD patients vs. 0.026 ± 0.084 in healthy controls, p = 0.0181) and abundant Gordinobacter pamelaeae (0.030±0.039 in the patients vs. 0.001±0.005 in healthy controls, p = 0.003) are strongly linked to MMD. Propionic acid levels were significantly lower in feces of the MMD patients compared to healthy controls (0.83 ± 0.34 mg/g in the MMD patients vs. 1.20 ± 0.55 mg/g in healthy controls, p = 0.028). CONCLUSION: Decreased Lactococcus lactis can result in reduced lactic acid and propionic acid levels in the feces of the patients. This imbalance in the gut microbiome and SCFA/organic acid levels could contribute to immune dysregulation underlying the vascular remodeling seen in MMD.
Intraoperative aneurysm flow analysis predicts intracranial large and giant aneurysm occlusion after flow diversion. International-journal Peer-reviewed

Yoshinari Osada, Hiroyuki Sakata, Masayuki Ezura, Kenichi Sato, Keisuke Sasaki, Shunsuke Omodaka, Atsushi Kanoke, Hiroki Uchida, Hidenori Endo

Clinical neurology and neurosurgery　250　108782-108782　2025/02/17

DOI： 10.1016/j.clineuro.2025.108782 　

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OBJECTIVES: Incompletely occluded flow-diverter (FD)-treated aneurysms are at risk of rupture and thromboembolic complications; however, intraoperative prediction of FD treatment outcomes has not yet been established. In this study, we investigated the association between intraoperative aneurysm flow analysis, using optical flow imaging, and FD treatment outcomes. MATERIALS AND METHODS: This retrospective study included patients with large unruptured internal carotid artery aneurysms (≥ 10 mm) who underwent FD treatment. During the procedure, a flow analysis method using optical flow digital subtraction angiography (DSA) was used to measure the flow within the aneurysm sac by calculating the mean aneurysm flow amplitude (MAFA) before and after stent deployment. Occlusion was assessed using the O'Kelly-Marotta (OKM) grading scale on DSA 12 months after FD. The patients were divided into a nearly complete occlusion group (OKM grades C and D) and an incomplete occlusion group (OKM grades A and B). RESULTS: Eleven patients with 11 aneurysms (mean age, 67.5 [standard deviation, 8.3] years; 10 women, 88.9 %) were treated with FD. Nearly complete occlusion was observed in 6/11 (54.5 %) patients at 12-month follow-up imaging. The nearly complete occlusion group had significantly lower pre-MAFA and post-MAFA values than the incomplete occlusion group (P = 0.023 and P = 0.008, respectively). There was no difference in the MAFA ratio between the two groups (P = 0.315) CONCLUSIONS: Aneurysm flow analysis before and after FD deployment is a simple and beneficial approach to predict treatment outcomes, which would indicate the need for intraoperative strategy changes, such as adding FD layers or intrasaccular coils.
Optimal intervention for ruptured cerebral arteriovenous malformation during pregnancy. International-journal Peer-reviewed

Youhei Takeuchi, Hiroyuki Sakata, Tomohisa Ishida, Masayuki Ezura, Hidenori Endo

Surgical neurology international　16　238-238　2025

DOI： 10.25259/SNI_320_2025 　

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BACKGROUND: Cerebral arteriovenous malformation (AVM) is a significant cause of hemorrhagic stroke in pregnant women. The risk of rebleeding after an initial hemorrhage during pregnancy is high, necessitating aggressive intervention and careful management. However, the optimal timing and method of intervention remain unclear. In particular, there has been little discussion regarding cases in which rebleeding occurred despite aggressive intervention. We present a case of cerebral AVM with intraventricular hemorrhage during pregnancy, which subsequently rebled after a cesarean section. CASE DESCRIPTION: A 30-year-old primigravida at 27 weeks of gestation presented with a sudden headache and was diagnosed with intraventricular hemorrhage. Magnetic resonance imaging revealed a flow void in the left fusiform gyrus, confirming a Spetzler-Martin Grade 2 AVM. Due to the deep location and limited safety data on Onyx use during pregnancy, surgery was postponed until after delivery. Cesarean section was planned at 32 weeks to ensure fetal viability. No rebleeding occurred preoperatively. At 32 weeks and 2 days, a cesarean section was performed under spinal anesthesia, delivering a male infant weighing 1,567 g. Postoperative computed tomography revealed intraventricular rebleeding, although no neurological deterioration occurred. Emergency transarterial embolization (TAE) with Onyx was performed the following day, followed by another TAE and AVM resection. Angiography confirmed complete lesion removal, and both the mother and child recovered favorably. CONCLUSION: Considering the high rates of rebleeding and the significant maternal and fetal mortality, prioritizing rebleeding prevention may be a key component of the intervention strategy for ruptured AVMs during pregnancy.
【虚血性脳血管障害】頭蓋内脳動脈狭窄症の血管内治療 Invited

坂田洋之, 針生新也, 佐藤健一, 江面正幸, 矢澤由加子, 面高俊介, 鹿毛淳史, 内田浩喜, 遠藤英徳

脳神経外科ジャーナル　33　(11)　764-769　2024/11
Publisher: (一社)日本脳神経外科コングレス
ISSN： 0917-950X

eISSN： 2187-3100
[Postoperative Management of Aneurysmal Subarachnoid Hemorrhage]. Invited

Hiroyuki Sakata, Hidenori Endo

No shinkei geka. Neurological surgery　52　(5)　906-913　2024/09
Publisher:
DOI： 10.11477/mf.1436204998 　

ISSN： 0301-2603

eISSN： 1882-1251

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Delayed cerebral ischemia(DCI) is one of the most significant complications of subarachnoid hemorrhage. Despite significant evolution in understanding DCI pathophysiology, vasospasm affecting cerebral vessels of large and moderate diameters remain the only clinically measurable component of DCI and is therefore the primary target for intervention in the postoperative management of subarachnoid hemorrhage. In Japan, fasudil hydrochloride and ozagrel sodium are widely used to prevent vasospasms; however, their effects are sometimes insufficient. Clazosentan, a selective endothelin receptor subtype A antagonist, reduces vasospasm-related morbidity and all-cause mortality following aneurysmal subarachnoid hemorrhage. This was demonstrated in a recent randomized phase 3 trial, leading to the approval of clazosentan by the Pharmaceuticals and Medical Devices Agency in Japan. Recent advances in our understanding of subarachnoid hemorrhage will facilitate improved management to reduce the incidence of DCI.
Aneurysm Wall Enhancement Can Predict Rupture Point in Intracranial Aneurysms With Multiple Blebs. International-journal Peer-reviewed

Shunsuke Omodaka, Shin-Ichiro Sugiyama, Hiroyuki Sakata, Kenichi Funamoto, Takuhiro Yamaguchi, Kuniyasu Niizuma, Hidenori Endo

Neurosurgery　2024/08/08

DOI： 10.1227/neu.0000000000003134 　

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BACKGROUND AND OBJECTIVES: Ruptured aneurysms visualized by vessel wall MRI (VW-MRI) exhibit characteristic aneurysm wall enhancement (AWE). A secondary bulge of the aneurysmal wall, called a bleb, is often the site of rupture in ruptured aneurysms. We hypothesized that a higher degree of AWE would identify the rupture point in aneurysms with multiple blebs. METHODS: AWE was quantitatively analyzed in consecutive ruptured intracranial aneurysms with multiple blebs (31 aneurysms with a total of 72 blebs) using VW-MRI. A 3-dimensional T1-weighted fast spin-echo sequence was obtained after contrast media injection, and the contrast ratio of the aneurysm wall against the pituitary stalk (CRstalk) was calculated as the AWE indicator. Bleb characteristics, including CRstalk and wall shear stress (WSS), were compared between ruptured and unruptured blebs. Odds ratios with 95% confidence intervals for ruptures were calculated by conditional logistic regression analysis. RESULTS: Ruptured blebs had a higher CRstalk and lower WSS compared with unruptured blebs. CRstalk remained significantly associated with the bleb rupture status in the conditional logistic regression (adjusted odds ratio 3.9, 95% CIs 1.6-9.7). CONCLUSION: AWE is associated with the bleb rupture status independent of WSS. Contrast-enhanced VW-MRI may be a useful noninvasive tool for identifying the rupture point and guiding the treatment strategy.
Paradoxical worsening of ocular symptoms after transvenous embolization of cavernous sinus dural arteriovenous fistula due to coil-induced perifocal inflammation: A case report. International-journal Peer-reviewed

Norihiro Iwamoto, Hiroyuki Sakata, Masayuki Ezura, Yoshinari Osada, Hidenori Endo, Teiji Tominaga

Clinical neurology and neurosurgery　236　108086-108086　2024/01

DOI： 10.1016/j.clineuro.2023.108086 　

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Ocular symptoms usually completely resolve after successful transvenous embolization of cavernous sinus dural arteriovenous fistulas (CS-dAVFs). Herein, we report a case of CS-dAVF in which sinus packing of the superior ophthalmic vein (SOV) caused coil-induced inflammation in orbital tissue, leading to deteriorating ocular symptoms. A 73-year-old woman presented with right-eye exophthalmos and chemosis. Cerebral angiography demonstrated right CS-dAVF, which retrogradely drained into the right SOV. We conducted sinus packing with coils via the right inferior petrosal sinus, resulting in obliteration of the shunts. One day after sinus packing, right exophthalmos and chemosis progressed, suggesting dAVF recurrence. However, no residual angiographic shunts were observed. Orbital magnetic resonance imaging (MRI) revealed edema in intraorbital tissue and gadolinium contrast enhancement of SOV wall. We presumed that the coils in SOV induced perifocal inflammation at the venous wall and surrounding orbital tissue, leading to aggravation of ocular symptoms. Following steroid therapy for 2 months, ocular symptoms and contrast enhancement on orbital MRI significantly improved without anticoagulant treatment. Posttreatment paradoxical worsening of ocular symptoms could be caused by coil-induced inflammation of the SOV wall near the orbital tissue. Steroid therapy could be effective in reducing orbital inflammatory reactions.
Prophylactic management of cerebral vasospasm with clazosentan in real clinical practice: a single-center retrospective cohort study. International-journal Peer-reviewed

Hiroyuki Sakata, Atsushi Kanoke, Hiroki Uchida, Shinya Haryu, Shunsuke Omodaka, Naoto Kimura, Masahiro Yoshida, Kuniyasu Niizuma, Teiji Tominaga, Hidenori Endo

Frontiers in neurology　15　1413632-1413632　2024

DOI： 10.3389/fneur.2024.1413632 　

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INTRODUCTION: Clazosentan, a selective endothelin receptor subtype A antagonist, reduces vasospasm-related morbidity and all-cause mortality following aneurysmal subarachnoid hemorrhage (SAH) in the Japanese population, as demonstrated by a recent randomized phase 3 trial. However, evidence to suggest clazosentan should be prioritized over the current standard of care to prevent cerebral vasospasm is still lacking. Therefore, we investigated the efficacy and safety of clazosentan in comparison with conventional postoperative management in real-world clinical practice. METHODS: We conducted a single-center, retrospective, observational cohort study using prospectively collected data from consecutive patients with aneurysmal SAH. After clazosentan was approved for use in Japan, the conventional postoperative management protocol, composed of intravenous fasudil chloride and oral cilostazol (control group, April 2021 to March 2022), was changed to the clazosentan protocol (clazosentan group, April 2022 to March 2023). The primary endpoint was the incidence of vasospasm-related symptomatic infarction. The secondary endpoints were favorable functional outcomes (modified Rankin scale score < 3) at discharge, angiographic vasospasm, and the need for rescue therapy for delayed cerebral ischemia. RESULTS: The analysis included 100 and 81 patients in the control and clazosentan groups, respectively. The incidence of vasospasm-related symptomatic infarction was significantly lower in the clazosentan group than in the control group (6.2% vs. 16%, p = 0.032). Multiple logistic analyses demonstrated that the use of clazosentan was independently associated with fewer incidence of vasospasm-related symptomatic infarct (23.8% vs. 47.5%, odds ratio 0.34 [0.12-0.97], p = 0.032). Clazosentan was significantly associated with favorable outcomes at discharge (79% vs. 66%, p = 0.037). Moreover, both the incidence of angiographic vasospasm (25.9% vs. 44%, p = 0.013) and the need for rescue therapy (16.1% vs. 34%, p = 0.006) was lower in the clazosentan group. The occurrence of pulmonary edema was significantly higher with clazosentan use (19.8% vs. 5%, p = 0.002), which did not result in morbidity. CONCLUSION: A postoperative management protocol centering on clazosentan was associated with the reduced vasospasm-related symptomatic infarction and improved clinical outcomes compared to the conventional management protocol in Japanese clinical practice. Clazosentan might be a promising treatment option for counteracting cerebral vasospasm after aneurysmal SAH.
Endovascular Treatment of Wide-Neck Bifurcation Aneurysm: Recent Trends in Coil Embolization with Adjunctive Technique. Peer-reviewed

Shinya Haryu, Hiroyuki Sakata, Yasushi Matsumoto, Kuniyasu Niizuma, Hidenori Endo

Journal of neuroendovascular therapy　18　(3)　75-83　2024

DOI： 10.5797/jnet.ra.2023-0072 　

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Wide-neck bifurcation aneurysms (WNBAs) are sometimes challenging to treat. During endovascular treatment, it is important to prevent coil deviation and preserve normal vessels. Adjunctive balloon- and stent-assisted techniques have been developed. A meta-analysis of endovascular treatments of WNBAs revealed that only 40% of patients had complete occlusion. Recently, novel devices have been developed to expand the range of treatment options. Flow-diverter stents and intra-aneurysmal flow disruption devices do not require coils; however, coil embolization remains the standard procedure used by many neurointerventionists. This review describes the recent trends in adjunctive techniques for supporting coil embolization for WNBAs. We referred to literature on balloon-assisted techniques, stent-assisted techniques, Y-stenting, PulseRider, Barrel stents, Comaneci temporary stents, pCONUS, and eCLIPs. These reports showed that adequate embolization rates were generally greater than 80%, and the complete occlusion rate was as high as 94.6%. All devices had a relatively high occlusion rate; however, it may be inaccurate to simply compare each device because of the heterogeneity of the studies. It is important to select the best treatment for each individual case by considering not only literature-based efficacy and safety but also patient background, aneurysm characteristics, and operator experience.
staged angioplastyの2回ともステント留置を要した頸部内頸動脈狭窄症の2例

田代亮介, 佐藤健一, 坂田洋之, 岩渕直也, 長田佳整, 江面正幸

脳血管内治療　8　(Suppl.)　S775-S775　2023/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
「くも膜下出血診療の最前線」クラゾセンタン単剤プロトコール導入によるくも膜下出血術後管理

遠藤英徳, 坂田洋之, 鹿毛淳史, 内田浩喜, 面高俊介, 新妻邦泰

脳循環代謝　35　(1)　41-41　2023/11
Publisher: (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
脳動脈瘤出血点予測における瘤壁造影効果の有用性

面高俊介, 坂田洋之, 杉山慎一郎, 新妻邦泰, 遠藤英徳

脳循環代謝　35　(1)　79-79　2023/11
Publisher: (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
チマメ状動脈瘤破裂によるくも膜下出血に対するhigh flow bypass後の血行動態

鹿毛淳史, 内田浩喜, 坂田洋之, 新妻邦泰, 遠藤英徳

脳循環代謝　35　(1)　84-84　2023/11
Publisher: (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
てんかん発作時と非発作時の脳血管撮影所見の比較

油川大輝, 鹿毛淳史, 内田浩喜, 川口奉洋, 坂田洋之, 鈴木一郎, 遠藤英徳

脳循環代謝　35　(1)　100-100　2023/11
Publisher: (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
複数回の血管内再治療を要した放射線誘発頸動脈狭窄症の2例

内田浩喜, 鹿毛淳史, 矢澤由加子, 坂田洋之, 松本康史, 新妻邦泰, 遠藤英徳

脳循環代謝　35　(1)　120-120　2023/11
Publisher: (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
IC-Pcom動脈瘤は血管内治療で制圧できるか内頸動脈後交通動脈分岐部動脈瘤に対する血管内治療 vessel wall imagingによる難治例予測と治療戦略の提唱

坂田洋之, 内田浩喜, 眞野唯, 鹿毛淳史, 新保大輔, 松本康史, 遠藤英徳

脳血管内治療　8　(Suppl.)　S42-S42　2023/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
中大脳動脈瘤治療における瘤壁造影効果と虚血性合併症の関連

鹿毛淳史, 坂田洋之, 内田浩喜, 面高俊介, 新妻邦泰, 松本康史, 遠藤英徳

脳血管内治療　8　(Suppl.)　S210-S210　2023/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
教師なし学習によるIC-Pcom動脈瘤の形態的クラスタリング血管内治療後の再発との関係性

内田浩喜, 杉山慎一郎, 鹿毛淳史, 坂田洋之, 遠藤英徳

脳血管内治療　8　(Suppl.)　S214-S214　2023/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
動眼神経麻痺で発症した未破裂内頸動脈-後交通動脈分岐部動脈瘤の瘤壁造影効果

面高俊介, 坂田洋之, 新妻邦泰, 松本康史, 遠藤英徳

脳血管内治療　8　(Suppl.)　S214-S214　2023/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
大型動脈瘤に対するFlow Diverterによる治療成績 vessel wall imagingによる難治例の予測は可能か

新保大輔, 坂田洋之, 眞野唯, 鹿毛淳史, 内田浩喜, 松本康史, 藤村幹, 遠藤英徳

脳血管内治療　8　(Suppl.)　S334-S334　2023/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
SHAP(SHapley Additive exPlanations)解析によるCEA/CASの決定過程の可視化

内田浩喜, 鹿毛淳史, 面高俊介, 坂田洋之, 遠藤英徳

脳血管内治療　8　(Suppl.)　S512-S512　2023/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
Six-month Outcomes after PulseRider- and Conventional Single Stent-assisted Embolization for Bifurcation Aneurysms: A Propensity-adjusted Comparison. Peer-reviewed

Shunsuke Omodaka, Yasushi Matsumoto, Takeshi Fujimori, Hiroyuki Sakata, Kenichi Sato, Kuniyasu Niizuma, Hidenori Endo, Teiji Tominaga

Neurologia medico-chirurgica　2023/09/23

DOI： 10.2176/jns-nmc.2023-0082 　

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Endovascular treatment of wide-necked bifurcation aneurysms (WNBAs) remains challenging despite using a stent. PulseRider is a novel device specifically designed to treat WNBAs, protecting both daughter branches, but the outcomes have not been compared with conventional single stent-assisted embolization. This study aimed to compare the six-month outcomes of PulseRider and single stent-assisted embolization for intracranial unruptured WNBAs using propensity score adjustment. Between February 2012 and October 2021, 46 unruptured WNBAs (34 basilar and 12 middle cerebral arteries) smaller than 10 mm in diameter were treated with PulseRider-assisted embolization (n = 17) or single stent-assisted embolization (n = 29). The immediate and six-month outcomes were compared using inverse probability of treatment weighting analysis. The immediate adequate occlusion rates for the PulseRider- and single stent-assisted embolization were similar (47.1% vs. 62.1%). At six months, adequate occlusion rates for the two groups were also similar (94.1% vs. 86.2%). However, the complete obliteration rate was significantly high after PulseRider-assisted embolization (88.2% vs. 41.4%, adjusted OR 10.54, 95% CI 1.93-57.63). The angiographical improvement rate was also significantly high after PulseRider-assisted embolization (70.6% vs. 37.9%, adjusted OR 6.06, 95% CI 1.54-23.76). The neurologic thromboembolic complication rate was 0% after PulseRider-assisted embolization and 3.4% after single stent-assisted embolization. PulseRider-assisted embolization of WNBAs smaller than 10 mm in diameter was associated with complete obliteration and angiographical improvement at six months. The unique shape of the PulseRider might contribute to the improved midterm aneurysm occlusion.
頭蓋内アテローム性動脈硬化症に対する急性期血行再建術の新たな治療戦略 stenting without retrieval法の提唱

坂田洋之, 江面正幸, 長田佳整, 斉藤敦志, 上之原広司, 冨永悌二

脳血管内治療　7　(Suppl.)　S100-S100　2022/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
急性期再開通療法の現状と課題頭蓋内アテローム性動脈硬化症に対する急性期血行再建術の治療戦略 stenting without retrieval法の提唱

坂田洋之, 江面正幸, 長田佳整, 斉藤敦志, 上之原広司, 冨永悌二

脳循環代謝　34　(1)　65-65　2022/10
Publisher: (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
Plasma tRNA derivatives concentrations for detecting early brain damage in patients with acute large vessel occlusion and predicting clinical outcomes after endovascular thrombectomy. International-journal Peer-reviewed

Tomohisa Ishida, Takashi Inoue, Kuniyasu Niizuma, Tomoo Inoue, Keisuke Sasaki, Hiroyuki Sakata, Masayuki Ezura, Hiroshi Uenohara, Takaaki Abe, Teiji Tominaga

Clinical neurology and neurosurgery　220　107358-107358　2022/07/01

DOI： 10.1016/j.clineuro.2022.107358 　

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OBJECTIVE: Transfer RNA (tRNA) is involved in the acute stress response, which results in conformational changes and subsequent fragmentation. Using an antibody against tRNA-specific modified nucleoside 1-methyladenosine, we can selectively detect blood tRNA derivatives from damaged tissues, including neuronal tissue, which serves as a potential marker of early tissue damage. This preliminary study aimed to investigate the correlation between tRNA derivatives and clinical outcomes in patients with acute anterior large vessel occlusion, especially those who underwent endovascular thrombectomy (EVT). METHODS: Patients with acute ischemic stroke due to anterior circulation large vessel occlusion were prospectively enrolled in this study. Plasma tRNA derivatives were measured using an enzyme-linked immunosorbent assay with an anti-modified nucleoside 1-methyladenosine antibody. RESULTS: Seventeen patients were included. The plasma tRNA derivatives concentrations on admission increased significantly, corresponding to the infarction size (r = 0.492, p = 0.038), and were associated with clinical outcomes (p = 0.00309). A good clinical outcome (90-day modified Rankin scale score: 0-2) was achieved in seven patients (41.2%), and all had undergone EVT. Among these patients, tRNA derivatives concentrations were the only preoperative predictor, which was associated with good outcomes (modified Rankin scale score: 0-2) and was significantly lower than those with poor outcomes (modified Rankin scale score: 3-6) (p = 0.0333). Receiver operating characteristic analysis revealed that a tRNA derivative value of ≤ 142.0 mg/mL was associated with good clinical outcomes, with a sensitivity of 85.7% and a specificity of 100% (area under the curve, 0.952; 95% confidence interval: 0.82-1). CONCLUSION: tRNA derivatives concentration may be a sensitive marker of early brain damage in patients with acute large vessel occlusion. Patients with low levels of tRNA derivatives on arrival are likely to benefit from thrombectomy and have the potential to achieve good clinical outcomes.
Rupture of an adjacent cerebral aneurysm following the deployment of a Pipeline embolization device: illustrative case International-journal Peer-reviewed

Atsushi Nakayashiki, Hiroyuki Sakata, Masayuki Ezura, Hidenori Endo, Takashi Inoue, Atsushi Saito, Teiji Tominaga

Journal of Neurosurgery: Case Lessons　3　(14)　2022/04/04
Publisher: Journal of Neurosurgery Publishing Group (JNSPG)
DOI： 10.3171/case21651 　

eISSN： 2694-1902

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BACKGROUND Although the Pipeline embolization device (PED) is effective for intracranial aneurysm treatment, its impact on the surrounding vascular structure is unknown. OBSERVATIONS A 71-year-old woman was incidentally found to have a simultaneous large posterior communicating artery aneurysm and an ipsilateral small anterior choroidal artery aneurysm. She underwent flow diversion therapy for both aneurysms with a PED, but the distal shortening of the PED after deployment led to the exposure of the anterior choroidal artery aneurysm. Follow-up angiography revealed complete obliteration of the posterior communicating artery aneurysm, but the anterior choroidal artery aneurysm remained. Three years after the endovascular surgery, the patient experienced a subarachnoid hemorrhage due to the rupture of the anterior choroidal artery aneurysm. Retrospective analysis of angiographic images revealed a change in the vascular geometry surrounding the ruptured aneurysm after PED deployment; this was further accompanied by an increase in the flow velocity inside the aneurysm. LESSONS Because PED use might induce the adverse effects on the adjacent uncovered aneurysm by changing the vascular geometry and hemodynamic stress, a cautious therapeutic strategy, such as proper placement of the stent and using a longer and appropriate-sized PED, should be chosen when deploying the PED.
Flow diverter therapy for immunosuppressant-resistant vertebral artery fusiform aneurysm due to eosinophilic granulomatosis with polyangiitis: illustrative case Peer-reviewed

Tetsuya Hayashi, Hiroyuki Sakata, Masayuki Ezura, Atsushi Saito, Yoshinari Osada, Teiji Tominaga

Journal of Neurosurgery: Case Lessons　3　(11)　2022/03/14
Publisher: Journal of Neurosurgery Publishing Group (JNSPG)
DOI： 10.3171/case21701 　

eISSN： 2694-1902

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BACKGROUND Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic small-vessel vasculitis characterized by the presence of asthma and eosinophilia. Because cerebral aneurysm formation induced by EGPA is a rare occurrence, there is no established treatment strategy for this condition. OBSERVATIONS A 67-year-old female who was diagnosed with idiopathic eosinophilia 3 months ago developed de novo fusiform aneurysms in the left vertebral, left internal carotid, and bilateral superficial temporal arteries, as noted during a regular follow-up examination of a convexity meningioma. Pathological examination of the resected superficial temporal artery revealed eosinophilic granulomas, which led to the diagnosis of EGPA, as well as EGPA-induced aneurysm formation. As the partially thrombosed vertebral artery fusiform aneurysm enlarged, the compression of the medulla oblongata occurred despite intensive immunosuppressive therapy for 1 year. The patient underwent flow diversion therapy administered using the pipeline embolization device, resulting in complete disappearance of the aneurysm. LESSONS Considering that the entire circumference of the aneurysmal wall is affected by necrotizing vasculitis, flow diverter therapy would be a reasonable and efficient approach for the treatment of EGPA-related aneurysms in cases in which the patient is nonresponsive to immunosuppressants.
Potential hemorrhagic risk of endovascular revascularization therapy due to recanalization of the dissected perforator in intracranial internal carotid artery dissection: A case report International-journal Peer-reviewed

Tomohisa Ishida, Hiroyuki Sakata, Masayuki Ezura, Takashi Inoue, Atsushi Saito, Hiroyoshi Suzuki, Teiji Tominaga

Surgical Neurology International　13　71-71　2022/02/25
Publisher: Scientific Scholar
DOI： 10.25259/sni_938_2021 　

eISSN： 2152-7806

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Background: Intracranial internal carotid artery (ICA) dissection manifesting as ischemic stroke is rare. Although endovascular revascularization therapy is effective in preventing the progression of stroke, little is known about the potential risk of this therapeutic approach. Case Description: We report a case of a 38-year-old woman who presented with acute ischemic infarcts in the territory of the left anterior choroidal artery (AChA) due to intracranial ICA dissection. She underwent balloon angioplasty, resulting in the complete resolution of the stenosis. The AChA, which was nearly occluded preoperatively, was unexpectedly recanalized after the procedure. Four hours later, she developed a parenchymal hemorrhage in the left basal ganglia without subarachnoid hemorrhage. The AChA, suspected as the hemorrhagic source during surgical hematoma removal, was revealed to have a disrupted internal elastic lamina on pathological examination, suggesting that the dissection of the ICA extended to the AChA. Conclusion: To the best of our knowledge, this is the first case report demonstrating that the intracranial ICA dissection extends to the associated perforator. Considering the potential risk of subsequent hemorrhagic complications by recanalization of the dissected perforator, prudent postoperative management, including strict blood pressure control, is advisable following endovascular revascularization therapy against intracranial artery dissection involving perforators.
Direct carotid puncture for endovascular surgery of intracranial aneurysms: Technical note for avoiding complications Peer-reviewed

Takatsugu Abe, Hiroyuki Sakata, Masayuki Ezura, Hidenori Endo, Teiji Tominaga

Surgical Neurology International　13　69-69　2022/02/25
Publisher: Scientific Scholar
DOI： 10.25259/sni_1147_2021 　

eISSN： 2152-7806

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Background: While the most intracranial aneurysms are approachable by femoral or brachial artery puncture during endovascular surgery, in some cases, the lesion is difficult to reach due to complications such as the presence of winding pathways. Direct carotid puncture (DCP) is an alternative access approach, despite the potential risk of fatal neck hematoma. Herein, we describe the DCP technique in a series of five patients with intracranial aneurysms, together with its technical considerations. Methods: Patients with intracranial aneurysms who underwent endovascular surgery using DCP were reviewed retrospectively. We selected the 3F to 6F systems for DCP depending on the necessity of adjunctive techniques. To prevent DCP-associated complications, we (1) conducted a micropuncture before introducing the short sheaths, (2) selected the smallest possible size for the system, (3) reversed heparin postoperatively, and (4) performed perioperative intubation/sedation management. Results: Five out of 535 patients underwent DCP in our hospital between 2015 and 2019; successful vascular access was achieved in all cases. Although a minor neck hematoma occurred in one case, the patient did not require additional treatment. According to a literature review, severe neck hematoma requiring rescue therapy occurs in 5 out of 95 cases (5.3%). Conclusion: Although the potential risk of neck hematoma is not negligible, the DCP technique appears to be a safe and effective approach in treating intracranial aneurysms with challenging access routes in cases where perioperative counter measurements are appropriately performed.
Rescue of distally placed stents in the setting of internal carotid artery dissection: A report of 2 cases with mechanistic insights. International-journal Peer-reviewed

Tomohisa Ishida, Hiroyuki Sakata, Masayuki Ezura, Shinichiro Osawa, Atsushi Saito, Teiji Tominaga

Clinical neurology and neurosurgery　214　107174-107174　2022/02/11

DOI： 10.1016/j.clineuro.2022.107174 　

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Potential procedural complications of endovascular therapy for carotid artery dissection have not been clarified. Herein, we present the cases of a 46-year-old woman and a 59-year-old man who underwent carotid artery stenting for left cervical internal carotid artery dissection. During the procedure, intramural hematoma was squeezed out by stent placement, causing further extension of the pseudolumen and a prominent stenosis proximal to the stent. Additional stent deployment was subsequently performed to fully cover the newly arising stenosis, resulting in good recanalization. In cases with a long-affected lesion, we should consider the potential risk of dissection advancement following stent deployment. Using longer stents or additional rescue stenting would be efficient in counteracting this rare complication.
Stent-Assisted Embolization for Acutely Ruptured Aneurysm Peer-reviewed

Masayuki Ezura, Hiroyuki Sakata, Tomohisa Ishida, Takashi Inoue, Hiroshi Uenohara

Journal of Neuroendovascular Therapy　16　(2)　74-81　2022
Publisher: The Japanese Society for Neuroendovascular Therapy
DOI： 10.5797/jnet.oa.2021-0010 　

ISSN： 1882-4072

eISSN： 2186-2494

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OBJECTIVE: The purpose of this study was to report the results of stent-assisted embolization performed at our hospital for acutely ruptured aneurysms. METHODS: This study consisted of 19 patients (4 men and 15 women) with acutely ruptured wide neck aneurysm who underwent stent-assisted coil embolization in acute stage between December 2016 and October 2020. Stent-assisted embolization in the acute stage was performed for very wide neck ruptured aneurysm only when balloon-assisted embolization was failed or was thought to be impossible. Factors related to poor clinical outcome were examined. RESULTS: There were nine internal carotid artery (ICA) aneurysms, four anterior communicating artery (AcomA) aneurysms, three basilar artery (BA) aneurysms, two vertebral artery (VA) aneurysms and one anterior cerebral artery (ACA) aneurysm. The stents used were one Neuroform EZ and 18 Neuroform Atlas (Stryker). The contrast of the bleb disappeared in all cases with obvious bleb. Complete obliteration was achieved in two cases, neck remnant was in ten, and body filling was in seven. Both of the complete obliteration cases developed thrombotic complications. Modified Rankin score of 0-2 was observed in eight patients (good clinical outcome), whereas that of 4-6 was observed in 11 patients (poor clinical outcome). Several factors possibly affected to poor clinical outcome were examined and only age over 80 years was statically different. Complications related to procedure occurred in five patients; two cases of in-stent thrombosis, one case each of MCA perforation, stent occlusion, and coil fracture. CONCLUSION: Stent-assisted coil embolization using Neuroform EZ and Neuroform Atlas could be considered as an emergency treatment for acutely ruptured cerebral aneurysms with very wide neck. It is rarely indicated in patients with age over 80 years.
脳梗塞:急性期治療治療前CT画像による血栓性状診断血栓回収療法の新たな治療戦略の提唱

坂田洋之, 江面正幸, 石田朋久, 斉藤敦志, 遠藤英徳, 上之原広司, 冨永悌二

脳循環代謝　33　(1)　71-71　2021/11
Publisher: (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
治療前CT画像による血栓性状診断血栓回収療法の新たな治療戦略の提唱

坂田洋之, 江面正幸, 石田朋久, 斉藤敦志, 遠藤英徳, 上之原広司, 冨永悌二

脳血管内治療　6　(Suppl.)　S11-S11　2021/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
Carotid artery stenting in a patient with an incidentally found double aortic arch: A case report. International-journal Peer-reviewed

Yuki Kitamura, Hiroyuki Sakata, Masayuki Ezura, Tomohisa Ishida, Hidenori Endo, Takashi Inoue, Teiji Tominaga

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences　27　(5)　15910199211001717-15910199211001717　2021/03/05

DOI： 10.1177/15910199211001717 　

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Double aortic arch is a type of congenital vascular ring, which rarely presents in adults. Herein, we report a case of carotid artery stenting (CAS) accompanied by an incidentally found double aortic arch. A 77-year-old man presented with bilateral severe carotid artery stenosis. The patient underwent truncal 3D-computed tomography angiography (CTA) to evaluate the access route before CAS, which lead to the diagnosis of an asymptomatic double aortic arch. Referring to the 3D-CTA images, a guiding catheter was successfully navigated to the targeted common carotid artery via the transfemoral approach despite the challenging, complex anatomy of the aortic arch. CAS was performed in both carotid arteries under distal balloon protection, without any neurological deficits. Considering the possible presence of anatomical variants such as double aortic arch, preoperative evaluation of the access route would be efficient for prospective CAS patients.
Bow hunter’s syndrome due to an embolic mechanism: illustrative case Peer-reviewed

Yuto Shingai, Hiroyuki Sakata, Toshiki Endo, Shinsuke Suzuki, Masayuki Ezura, Teiji Tominaga

Journal of Neurosurgery: Case Lessons　1　(7)　2021/02/15
Publisher: Journal of Neurosurgery Publishing Group (JNSPG)
DOI： 10.3171/case20150 　

eISSN： 2694-1902

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<sec><title>BACKGROUND</title>Bow hunter’s syndrome (BHS) is an uncommon cause of vertebrobasilar ischemic stroke, which results from occlusion or injury to the vertebral artery (VA) during neck rotation. Although hemodynamic insufficiency is the predominant underlying mechanism of this entity, BHS due to embolic mechanisms is rare. The authors report a case of BHS characterized by repeated posterior circulation embolism and present some considerations of BHS with an embolic mechanism. </sec><sec><title>OBSERVATIONS</title>A 57-year-old man suffered from repeated embolic stroke in the posterior circulation. Digital subtraction angiography revealed caliber irregularity of the V3 segment of the left nondominant-side VA, which occluded when the neck rotated to the right side. The patient was diagnosed with BHS with an embolic mechanism due to endothelial damage caused by osteophytes at the C1 foramen transversarium. After C1–C2 fusion surgery, the patient never experienced the recurrence of stroke. According to a literature review, BHS due to embolic mechanisms tends to occur in young male adults, manifesting as recurrent stroke in the posterior circulation. Involvement of the nondominant-side VA can cause BHS with an underlying embolic mechanism. </sec><sec><title>LESSONS</title>BHS due to an embolic mechanism should be considered as a differential diagnosis if patients have repeated embolic strokes in the posterior circulation. </sec>
救うぞ!「脳」を(破裂脳動脈瘤)治療戦略破裂急性期脳動脈瘤に対するステント併用コイル塞栓術(第二報)

江面正幸, 坂田洋之, 石田朋久, 遠藤英徳, 井上敬, 上之原広司

Neurosurgical Emergency　25　(3)　474-474　2021/02
Publisher: (NPO)日本脳神経外科救急学会
ISSN： 1342-6214
Carotid Artery Stenting Using Balloon-Expandable Coronary Stent: Intentional Use for Staged Angioplasty Peer-reviewed

Masayuki Ezura, Naoto Kimura, Hiroyuki Sakata, Tomohisa Ishida, Takashi Inoue, Hiroshi Uenohara

Journal of Neuroendovascular Therapy　15　(9)　621-628　2021
Publisher: The Japanese Society for Neuroendovascular Therapy
DOI： 10.5797/jnet.tn.2020-0154 　

ISSN： 1882-4072

eISSN： 2186-2494

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OBJECTIVE: We report carotid artery stenting (CAS) using balloon-expandable coronary (BECo) stent. The materials in this study consist of 15 cases of high-grade stenosis in internal carotid artery (ICA) in which self-expanding carotid (SECa) stent was not utilized. There were two groups why BECo stent was used instead of SECa stent: alternative group and intentional group. The alternative group was subdivided into two groups: access difficulty of guiding catheter and access difficulty of SECa stent. CASE PRESENTATION: The alternative group included 11 cases (access difficulty of guiding catheter in 10 and access difficulty of SECa stent in 1), and the intentional group included 4 cases. There were four cases using transbrachial approach. All the intentional group cases were the first stage of staged angioplasty (SAP). The second stage of SAP was PTA in two and SECa stent over the BECo stent in two. There was no complication related to CAS. CONCLUSION: CAS using BECo stent is one of the choices for the first stage of SAP, if stent placement instead of PTA is required at the first stage. It is also the useful alternative for the patient having difficulty of SECa stent.
Intraaneurysmal Neck Plasty: Efficacy of a Super Compliant Double-Lumen Balloon Microcatheter Peer-reviewed

Masayuki Ezura, Naoto Kimura, Hiroyuki Sakata, Tomohisa Ishida, Takashi Inoue, Hiroshi Uenohara

Journal of Neuroendovascular Therapy　15　(5)　301-309　2021
Publisher: The Japanese Society for Neuroendovascular Therapy
DOI： 10.5797/jnet.oa.2020-0148 　

ISSN： 1882-4072

eISSN： 2186-2494

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OBJECTIVE: While wide-neck aneurysms can be treated with several methods, we report the specific technique of intraaneurysmal neck plasty (IANP) with a super compliant double-lumen balloon microcatheter (Super-Masamune). METHODS: The Super-Masamune was inflated inside 18 aneurysms. Cases in which the tip of the Super-Masamune was located in the aneurysm were included. Embolization methods were the same as those used in the application of other balloons/stents. The use of the Super-Masamune for the performance of IANP followed two patterns: (1) the Super-Masamune was used not only as a balloon but also for coil insertion (simple IANP); (2) the Super-Masamune was used only as a balloon, and a microcatheter for coil insertion was separately introduced coaxially (coaxial IANP). RESULTS: The aneurysms were located in the anterior communicating artery (n = 6), middle cerebral artery (MCA; n = 4), anterior cerebral artery (n = 1), internal carotid artery (n = 5), basilar artery (n = 1), and vertebral artery (n = 1). Eight of the aneurysms were ruptured, while 10 were unruptured. Simple and coaxial IANP were both performed in seven cases. Embolization was not performed after inflating the Super-Masamune inside the aneurysm in four cases. Embolization grades following the procedure included eight neck remnants (NRs) and six body fillings (BFs). There was one complication of intraoperative rerupture; however, there was no rupture/rerupture in the follow-up period. Retreatment of the target aneurysm was performed in two cases. The embolization grade assessed in the follow-up period reached complete occlusion for one patient, NR for five, and BF for two patients. CONCLUSION: IANP using the Super-Masamune is useful for the treatment of wide-neck aneurysms in which the introduction of a guidewire and/or microcatheter into the branching artery is difficult.
Mechanical thrombectomy for elderly patients with acute ischemic stroke Invited

Geriatric Neurosurgery　34　9-12　2021
Publisher:
ISSN： 1343-4233

eISSN： 2436-6064
Intentional Stent Herniation Technique Using Neuroform Atlas Stent System for Embolization of a Wide-Necked Basilar Tip Aneurysm Peer-reviewed

Hiroyuki Sakata, Masayuki Ezura, Takatsugu Abe, Tomohisa Ishida, Hidenori Endo, Takashi Inoue, Toshiki Endo, Hiroshi Uenohara, Teiji Tominaga

Journal of Neuroendovascular Therapy　15　(12)　823-828　2021
Publisher: The Japanese Society for Neuroendovascular Therapy
DOI： 10.5797/jnet.tn.2020-0155 　

ISSN： 1882-4072

eISSN： 2186-2494

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OBJECTIVE: Endovascular treatment for complex wide-necked basilar tip aneurysms is challenging. Multiple stenting may be an option to deal with such aneurysms; however, the risk of ischemic complications is reported to be relatively high. Here, we report a case of unruptured basilar tip aneurysm treated using the intentional stent herniation technique to preserve the aneurysmal neck branches. CASE PRESENTATION: A 65-year-old woman presented with a growing unruptured basilar tip aneurysm associated with bilateral posterior cerebral arteries (PCAs) arising from the aneurysmal dome. We intentionally selected a large-sized Neuroform Atlas stent (Stryker, Kalamazoo, MI, USA) compared to the parent artery and deployed it along the right PCA to the basilar artery. The stent was herniated into the aneurysmal dome near the origin of the left PCA, resulting in the preservation of the left PCA. Successful coil embolization was achieved with acceptable obliteration. CONCLUSION: The intentional stent herniation technique may be an effective approach to treat complex wide-necked basilar tip aneurysms.
Preservation of Branching Vessel Using Super Compliant Double-Lumen Balloon Microcatheter: Bulging Neck Plasty Technique and Other Options Peer-reviewed

Hiroyuki Sakata, Masayuki Ezura, Naoto Kimura, Tomohisa Ishida, Takashi Inoue, Hiroshi Uenohara, Teiji Tominaga

Journal of Neuroendovascular Therapy　15　(5)　310-315　2021
Publisher: The Japanese Society for Neuroendovascular Therapy
DOI： 10.5797/jnet.oa.2020-0152 　

ISSN： 1882-4072

eISSN： 2186-2494

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OBJECTIVE: There are several methods to treat wide-neck aneurysms. We survey the cases that were treated using a super-compliant double-lumen balloon microcatheter (Super-Masamune) for preservation of the branching vessel originating proximal to the aneurysm, especially in the bulging neck plasty (BNP) technique. METHODS: We assessed 10 cases in which branching vessel preservation was performed using Super-Masamune. The cases were categorized into three groups: (1) ordinary neck plasty (ONP): balloon microcatheter was navigated to the branch that should be preserved; (2) BNP: another branch was preserved by inflating balloon bulging without cannulation; (3) protection during parent artery occlusion (PPO): the balloon microcatheter was navigated to the vessel to be occluded. The balloon preserves a branch originating near the aneurysm without cannulating to the branch. RESULTS: The aneurysm locations were as follows: internal carotid artery (ICA), three cases; anterior communicating artery (AcomA), one case; basilar artery (BA), three cases; and vertebral artery (VA), three cases. Four cases were ruptured aneurysms, while six cases were unruptured or ruptured in chronic stage. The ONP, BNP, and PPO groups contained two, five, and three cases, respectively. Embolization resulted in complete obliteration in six cases, neck remnant in two cases and body filling in two cases. No rupture/rerupture was noted in this series. One case showed an intraoperative rupture. CONCLUSION: Super-Masamune is useful for neck plasty, especially BNP, in wide-neck aneurysms. Super-Masamune is also useful for parent artery occlusion when an important branch originates proximal to the aneurysm.
2D perfusion angiographyを用いた頸動脈ステント留置術後の過灌流予測

坂田洋之, 江面正幸, 石田朋久, 阿部考貢, 井上敬, 遠藤英徳, 遠藤俊毅, 上之原広司, 冨永悌二

脳循環代謝　32　(1)　74-74　2020/11
Publisher: (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
脳動脈瘤は無症候性脳梗塞発症のリスクファクター

井上敬, 遠藤英徳, 坂田洋之, 石田朋久, 江面正幸, 上之原広司, 冨永悌二

脳循環代謝　32　(1)　79-79　2020/11
Publisher: (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
Intraaneurysmal Neck Plasty スーパーコンプライアントダブルルーメンバルーンカテーテルを用いた方法

江面正幸, 木村尚人, 坂田洋之, 石田朋久, 井上敬, 上之原広司

脳血管内治療　5　(Suppl.)　40-40　2020/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
2D perfusion angiographyを用いた頸動脈ステント留置術後の過灌流予測

坂田洋之, 江面正幸, 阿部考貢, 石田朋久, 井上敬, 遠藤英徳, 遠藤俊毅, 冨永悌二

脳血管内治療　5　(Suppl.)　6-6　2020/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
頸動脈ステント留置術後の過灌流に対するミノサイクリン塩酸塩を用いた周術期管理

坂田洋之, 江面正幸, 石田朋久, 阿部考貢, 井上敬, 遠藤英徳, 冨永悌二

脳血管内治療　5　(Suppl.)　45-45　2020/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
2D perfusion angiographyを用いた頸動脈ステント留置術後の過灌流予測

坂田洋之, 江面正幸, 石田朋久, 阿部考貢, 井上敬, 遠藤英徳, 遠藤俊毅, 上之原広司, 冨永悌二

脳循環代謝　32　(1)　74-74　2020/11
Publisher: (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
脳動脈瘤は無症候性脳梗塞発症のリスクファクター

井上敬, 遠藤英徳, 坂田洋之, 石田朋久, 江面正幸, 上之原広司, 冨永悌二

脳循環代謝　32　(1)　79-79　2020/11
Publisher: (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
[Temporal Profiles of Neuroimaging Features of Non-haemorrhagic and Non-ischemic Vertebral Artery Dissections for Conservative Treatment]. Peer-reviewed

Taigen Nakamura, Kensuke Murakami, Hiroyuki Sakata

No shinkei geka. Neurological surgery　48　(4)　307-315　2020/04

DOI： 10.11477/mf.1436204183 　

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Most patients with non-hemorrhagic and non-ischemic vertebral artery dissections(VADs)are likely to recover with good outcomes. In contrast, some cases of uneventful outcomes have also been reported. Therefore, whether surgical treatment or prolonged follow-up should be utilized for each case remains controversial. In this study, we retrospectively investigated the radiological features and changes in non-hemorrhagic and non-ischemic VADs during the follow-up period. We reviewed the medical records of 15 consecutive patients with VADs without hemorrhage or ischemic lesions diagnosed between 2008 and 2017; all patients reported severe occipital headache. All hemorrhagic and ischemic lesions were categorized into morphological types according to the initial radiological findings. The following morphological types of dissections were observed: six cases, pearl and string type; six cases, dilatation type; two cases, stenosis type; and one case, occlusion type. We observed morphological aggravation in four cases, and among them, three underwent surgical interventions. Seven patients recovered during the follow-up period, and five of them showed marked radiological changes within 2 months. One patient died fromethe clinical onset. Therefore, careful follow-up radiological imaging is presumably necessary for patients with non-hemorrhagic and non-ischemic VADs, within at least 2 months of the clinical onset because of the tendency of VADs for rapid morphological changes during that period.
非出血性・非虚血性椎骨動脈解離の経時的画像所見変化に関する検討 Peer-reviewed

中村太源, 村上謙介, 坂田洋之

脳神経外科　48　(4)　307-315　2020/04
Symptomatic cerebral hyperperfusion following cerebral vasospasm associated with aneurysmal subarachnoid hemorrhage: a case report. International-journal Peer-reviewed

Hiroyuki Sakata, Hidenori Endo, Miki Fujimura, Kuniyasu Niizuma, Teiji Tominaga

World neurosurgery　2020/02/24

DOI： 10.1016/j.wneu.2020.02.092 　

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BACKGROUND: Cerebral hyperperfusion syndrome, which carries a potential risk of intracranial hemorrhage, is a rare and overlooked condition in the setting of subarachnoid hemorrhage (SAH). CASE DESCRIPTION: A 72-year-old female presenting with SAH underwent clipping of a ruptured aneurysm of the left middle cerebral artery. On post-SAH day 7, the patient exhibited motor aphasia due to cerebral vasospasm of the left middle cerebral artery. After recovery from symptomatic cerebral vasospasm, the patient became restless and suffered from right hemiparesis on post-SAH day 12. Initially, recurrence of cerebral vasospasm was suspected; however, cerebral blood flow measurement using single-photon emission computed tomography (SPECT) revealed apparently increased perfusion in the same territory of the left middle cerebral artery. Hypertensive therapy was not induced during the postoperative period. Her neurological symptoms and signs of cerebral hyperperfusion gradually improved with intensive blood pressure lowering. CONCLUSIONS: This is the first report to describe postischemic cerebral hyperperfusion syndrome following symptomatic vasospasm detected using sequential SPECT during the acute stage of SAH. Early diagnosis of this rare phenomenon is crucial given the necessity to lower blood pressure for preventing hemorrhagic complications, which is contrary to the usual management of patients with vasospasm.
部分血栓化脳動脈瘤を塞栓源とした塞栓性脳梗塞の一例

後藤悠樹, 張替宗介, 船山由希乃, 結城翼, 中村貴彬, 菅谷涼, 川崎永美子, 渡辺源也, 突田健一, 鈴木靖士, 坂田洋之, 江面正幸

臨床神経学　59　(11)　758-758　2019/11
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
Genetic analysis of ring finger protein 213 (RNF213) c.14576G>A polymorphism in patients with vertebral artery dissection: a comparative study with moyamoya disease. Peer-reviewed

Tashiro R, Fujimura M, Sakata H, Endo H, Tomata Y, Sato-Maeda M, Niizuma K, Tominaga T

Neurological research　1-6　2019/09

DOI： 10.1080/01616412.2019.1615726 　

ISSN： 0161-6412
Unilateral chronic subdural hematoma due to spontaneous intracranial hypotension: a report of four cases. International-journal Peer-reviewed

Osada Y, Shibahara I, Nakagawa A, Sakata H, Niizuma K, Saito R, Kanamori M, Fujimura M, Suzuki S, Tominaga T

British journal of neurosurgery　34　(6)　1-6　2019/09

DOI： 10.1080/02688697.2019.1667482 　

ISSN： 0268-8697

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Background: Chronic subdural hematoma (CSDH) is a common neurosurgical disease. A subset of patients with CSDH may exhibit underlying spontaneous intracranial hypotension (SIH). Bilateral CSDH has a causal relationship with SIH, but there is no known causal relationship between unilateral CSDH and SIH.Case description: We encountered four cases of unilateral CSDH due to SIH. The patients' age ranged between 44 and 64 years; there were three males and one female. All patients presented with headache as their initial symptom, and then became comatose. Computed tomography demonstrated unilateral CSDH and transtentorial herniation in all patients. Treatments were emergency epidural blood patch (EBP) and evacuation of CSDH. The site of cerebrospinal fluid leak could not be identified in three patients; therefore, EBP was performed at upper and lower spine. All patients recovered from SIH; however, one patient experienced poor outcome due to Duret hemorrhage and ischemic complications of transtentorial herniation. Cranial asymmetry was present in all four patients, and unilateral CSDH was located on the side of the most curved cranial convexity.Conclusions: Unilateral CSDH, asymmetric cranial morphology, and transtentorial herniation in relatively young patients may indicate underlying SIH.
Identification of HLA-DRB1*04:10 allele as risk allele for Japanese moyamoya disease and its association with autoimmune thyroid disease: A case-control study. Peer-reviewed

Tashiro R, Niizuma K, Khor SS, Tokunaga K, Fujimura M, Sakata H, Endo H, Inoko H, Ogasawara K, Tominaga T

PloS one　14　(8)　e0220858　2019

DOI： 10.1371/journal.pone.0220858 　
Cord Compression Caused by a Tangled and Warped Lumbar Catheter After Lumboperitoneal Shunt Placement. Peer-reviewed

Sato K, Endo T, Sakata H, Inoue T, Niizuma K, Tominaga T

Neurospine　2018/10

DOI： 10.14245/ns.1836114.057 　

ISSN： 2586-6583
Transient Global Cerebral Ischemia Induces RNF213, a Moyamoya Disease Susceptibility Gene, in Vulnerable Neurons of the Rat Hippocampus CA1 Subregion and Ischemic Cortex Peer-reviewed

Mika Sato-Maeda, Miki Fujimura, Sherif Rashad, Yuiko Morita-Fujimura, Kuniyasu Niizuma, Hiroyuki Sakata, Shuntaro Ikawa, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　26　(9)　1904-1911　2017/09

DOI： 10.1016/j.jstrokecerebrovasdis.2017.06.032 　

ISSN： 1052-3057

eISSN： 1532-8511
Uneven cerebral hemodynamic change as a cause of neurological deterioration in the acute stage after direct revascularization for moyamoya disease: cerebral hyperperfusion and remote ischemia caused by the 'watershed shift' Peer-reviewed

Xian-kun Tu, Miki Fujimura, Sherif Rashad, Shunji Mugikura, Hiroyuki Sakata, Kuniyasu Niizuma, Teiji Tominaga

NEUROSURGICAL REVIEW　40　(3)　507-512　2017/07

DOI： 10.1007/s10143-017-0845-9 　

ISSN： 0344-5607

eISSN： 1437-2320
Navigation-guided clipping of a de novo aneurysm associated with superficial temporal artery-middle cerebral artery bypass combined with indirect pial synangiosis in a patient with moyamoya disease Peer-reviewed

Daiki Aburakawa, Miki Fujimura, Kuniyasu Niizuma, Hiroyuki Sakata, Hidenori Endo, Teiji Tominaga

NEUROSURGICAL REVIEW　40　(3)　517-521　2017/07

DOI： 10.1007/s10143-017-0866-4 　

ISSN： 0344-5607

eISSN： 1437-2320
De Novo Development of Moyamoya Disease in an Adult Female with a Genetic Variant of the RNF-213 Gene: Case Report Peer-reviewed

Ryosuke Tashiro, Miki Fujimura, Kuniyasu Niizuma, Hidenori Endo, Hiroyuki Sakata, Mika Sato-Maeda, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　26　(1)　E8-E11　2017/01

DOI： 10.1016/j.jstrokecerebrovasdis.2016.09.035 　

ISSN： 1052-3057

eISSN： 1532-8511
Hypoxic preconditioning enhances neural stem cell transplantation therapy after intracerebral hemorrhage in mice Peer-reviewed

Takuma Wakai, Purnima Narasimhan, Hiroyuki Sakata, Eric Wang, Hideyuki Yoshioka, Hiroyuki Kinouchi, Pak H. Chan

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　36　(12)　2134-2145　2016/12

DOI： 10.1177/0271678X15613798 　

ISSN： 0271-678X

eISSN： 1559-7016
再生医療の基礎と臨床UP to DATE Muse細胞による脳梗塞治療

新妻邦泰, 坂田洋之, 内田浩喜, 森田隆弘, 阿部考貢, 藤村幹, 出澤真理, 冨永悌二

脳循環代謝　28　(1)　127-127　2016/11
Publisher: (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
Development of Abnormal Hemispheric Vascular Networks Mimicking Cerebral Proliferative Angiopathy in a Child Originally Diagnosed with Deep-Seated Arteriovenous Fistula Peer-reviewed

Hiroyuki Sakata, Miki Fujimura, Kenichi Sato, Kuniyasu Niizuma, Hidenori Endo, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　25　(10)　E200-E204　2016/10

DOI： 10.1016/j.jstrokecerebrovasdis.2016.07.042 　

ISSN： 1052-3057

eISSN： 1532-8511
Temporal profile of magnetic resonance angiography and decreased ratio of regulatory T cells after immunological adjuvant administration to mice lacking RNF213, a susceptibility gene for moyamoya disease Peer-reviewed

Atsushi Kanoke, Miki Fujimur, Kuniyasu Niizuma, Taku Fujimura, Aya Kakizaki, Akira Ito, Hiroyuki Sakata, Mika Sato-Maeda, Shigeo Kure, Teiji Tominaga

BRAIN RESEARCH　1642　1-9　2016/07

DOI： 10.1016/j.brainres.2016.03.009 　

ISSN： 0006-8993

eISSN： 1872-6240
Transplantation of Unique Subpopulation of Fibroblasts, Muse Cells, Ameliorates Experimental Stroke Possibly via Robust Neuronal Differentiation Peer-reviewed

Hiroki Uchida, Takahiro Morita, Kuniyasu Niizuma, Yoshihiro Kushida, Yasumasa Kuroda, Shohei Wakao, Hiroyuki Sakata, Yoshiya Matsuzaka, Hajime Mushiake, Teiji Tominaga, Cesario V. Borlongan, Mari Dezawa

STEM CELLS　34　(1)　160-173　2016/01

DOI： 10.1002/stem.2206 　

ISSN： 1066-5099

eISSN： 1549-4918
A case of ruptured infectious anterior cerebral artery aneurysm treated by interposition graft bypass using the superficial temporal artery. Peer-reviewed

Abe T, Endo H, Shimizu H, Fujimura M, Endo T, Sakata H, Watanabe M, Tominaga T

Surgical neurology international　7　5　2016

DOI： 10.4103/2152-7806.173319 　

ISSN： 2229-5097
Experimental model of small subcortical infarcts in mice with long-lasting functional disabilities Peer-reviewed

Hiroki Uchida, Hiroyuki Sakata, Miki Fujimura, Kuniyasu Niizuma, Yoshihiro Kushida, Mari Dezawa, Teiji Tominaga

BRAIN RESEARCH　1629　318-328　2015/12

DOI： 10.1016/j.brainres.2015.10.039 　

ISSN： 0006-8993

eISSN： 1872-6240
Risk factors for meningitis after craniotomy in patients with subarachnoid hemorrhage due to anterior circulation aneurysms rupture Peer-reviewed

Takashi Inoue, Hiroaki Shimizu, Miki Fujimura, Kenichi Sato, Hidenori Endo, Kuniyasu Niizuma, Hiroyuki Sakata, Teiji Tominaga

CLINICAL NEUROLOGY AND NEUROSURGERY　139　302-306　2015/12

DOI： 10.1016/j.clineuro.2015.10.029 　

ISSN： 0303-8467

eISSN： 1872-6968
Temporal profile of the vascular anatomy evaluated by 9.4-tesla magnetic resonance angiography and histological analysis in mice with the R4859K mutation of RNF213, the susceptibility gene for moyamoya disease Peer-reviewed

Atsushi Kanoke, Miki Fujimura, Kuniyasu Niizuma, Akira Ito, Hiroyuki Sakata, Mika Sato-Maeda, Yuiko Morita-Fujimura, Shigeo Kure, Teiji Tominaga

BRAIN RESEARCH　1624　497-505　2015/10

DOI： 10.1016/j.brainres.2015.07.039 　

ISSN： 0006-8993

eISSN： 1872-6240
Local Vasogenic Edema without Cerebral Hyperperfusion after Direct Revascularization Surgery for Moyamoya Disease Peer-reviewed

Hiroyuki Sakata, Miki Fujimura, Shunji Mugikura, Kenichi Sato, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　24　(7)　E179-E184　2015/07

DOI： 10.1016/j.jstrokecerebrovasdis.2015.03.050 　

ISSN： 1052-3057

eISSN： 1532-8511
頸動脈ステント留置術施行後に頸動脈エコーで無症候性総頸動脈解離を捉えた一例

重畠裕也, 板橋亮, 川田健太, 矢澤由加子, 面高俊介, 坂田洋之, 佐藤健一, 松本康史, 古井英介

Neurosonology　28　(増刊)　119-119　2015/06
Publisher: (一社)日本脳神経超音波学会
ISSN： 0917-074X
[A case of atherothrombotic embolization developing with slowly progressive symptoms and requiring differential diagnosis from metastatic tumor recurrence]. Peer-reviewed

Sho Umegaki, Ryuta Saito, Yosuke Akamatsu, Hiroyuki Sakata, Ken-Ichi Sato, Miki Fujimura, Yukihiko Sonoda, Teiji Tominaga

No shinkei geka. Neurological surgery　43　(4)　339-43　2015/04

DOI： 10.11477/mf.1436203017 　

ISSN： 0301-2603

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We report a case of atherothrombotic embolization that developed with slowly progressive symptoms and required differential diagnosis from metastatic tumor recurrence. A 64-year-old man with a history of lung cancer and metastatic brain tumor was carefully followed at our outpatient department for tumor recurrence. Five years after surgery for brain metastasis and whole brain radiation therapy, he had no recurrence and systemic disease was well controlled. At a routine follow up in October 2013, he complained of slight right arm dysesthesia. Follow up brain magnetic resonance (MR) imaging revealed no lesion. Two months later, he developed right hemiparesthesia and gait disturbance. Spinal MR imaging was unremarkable. However, at a routine follow up in January 2014, multiple enhancements were detected near the resection cavity and regions delineating the sulci. At first, this was diagnosed as tumor recurrence. However, 3 days later, additional MR imaging detected new multiple small infarctions after worsening right hemiparesis and dysarthria. With the diagnosis of embolic stroke, we searched for an embolic source. Cardiogenic embolization and carotid bifurcation stenosis studies were negative, but severe stenosis and thrombosis were detected near the left common carotid artery origin. This site was in the field of radiation the patient received as treatment for primary lung cancer.
A case of akin moyamoya disease associated with type-I diabetes mellitus managed by extracranial-intracranial bypass Peer-reviewed

Yosuke Akamatsu, Miki Fujimura, Hiroyuki Sakata, Hidenori Endo, Ryo Itabashi, Teiji Tominaga

Neurological Surgery　43　(3)　227-233　2015/03/01
Publisher: Igaku-Shoin Ltd
DOI： 10.11477/mf.1436202991 　

ISSN： 1882-1251 0301-2603
Enhanced post-ischemic angiogenesis in mice lacking RNF213; a susceptibility gene for moyamoya disease Peer-reviewed

Akira Ito, Miki Fujimura, Kuniyasu Niizuma, Atsushi Kanoke, Hiroyuki Sakata, Yuiko Morita-Fujimura, Atsuo Kikuchi, Shigeo Kure, Teiji Tominaga

BRAIN RESEARCH　1594　310-320　2015/01

DOI： 10.1016/j.brainres.2014.11.014 　

ISSN： 0006-8993

eISSN： 1872-6240
Efficacy of Extracranial-Intracranial Bypass for Progressive Middle Cerebral Artery Occlusion Associated with Active Sjogren's Syndrome: Case Report Peer-reviewed

Hiroyuki Sakata, Miki Fujimura, Kenichi Sato, Hiroaki Shimizu, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　23　(8)　E399-E402　2014/09

DOI： 10.1016/j.jstrokecerebrovasdis.2014.02.022 　

ISSN： 1052-3057

eISSN： 1532-8511
Genetics and Biomarkers of Moyamoya Disease: Significance of RNF213 as a Susceptibility Gene Peer-reviewed

Miki Fujimura, Shinya Sonobe, Yasuo Nishijima, Kuniyasu Niizuma, Hiroyuki Sakata, Shigeo Kure, Teiji Tominaga

JOURNAL OF STROKE　16　(2)　65-72　2014/05

DOI： 10.5853/jos.2014.16.2.65 　

ISSN： 2287-6391

eISSN： 2287-6405
Transplantation of neural stem cells that overexpress SOD1 enhances amelioration of intracerebral Peer-reviewed

Takuma Wakai, Hiroyuki Sakata, Purnima Narasimhan, Hideyuki Yoshioka, Hiroyuki Kinouchi, Pak H. Chan

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　34　(3)　441-449　2014/03

DOI： 10.1038/jcbfm.2013.215 　

ISSN： 0271-678X

eISSN： 1559-7016
Cardiopulmonary complication as a pitfall of the perioperative management of moyamoya syndrome with atherosclerosis: Conflict to counteract with cerebral hyperperfusion Peer-reviewed

Hiroyuki Sakata, Miki Fujimura, Kenichi Sato, Hiroaki Shimizu, Teiji Tominaga

Neurological Surgery　42　(8)　737-743　2014
Publisher: Igaku-Shoin Ltd
ISSN： 1882-1251 0301-2603

eISSN： 1882-1251
The role of PARL and HtrA2 in striatal neuronal injury after transient global cerebral ischemia Peer-reviewed

Hideyuki Yoshioka, Masataka Katsu, Hiroyuki Sakata, Nobuya Okami, Takuma Wakai, Hiroyuki Kinouchi, Pak H. Chan

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　33　(11)　1658-1665　2013/11

DOI： 10.1038/jcbfm.2013.139 　

ISSN： 0271-678X

eISSN： 1559-7016
Prevention of JNK phosphorylation as a mechanism for rosiglitazone in neuroprotection after transient cerebral ischemia: activation of dual specificity phosphatase Peer-reviewed

Nobuya Okami, Purnima Narasimhan, Hideyuki Yoshioka, Hiroyuki Sakata, Gab Seok Kim, Joo Eun Jung, Carolina M. Maier, Pak H. Chan

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　33　(1)　106-114　2013/01

DOI： 10.1038/jcbfm.2012.138 　

ISSN： 0271-678X
Childhood transverse sinus dural arteriovenous fistula treated with endovascular and direct surgery: A case report Peer-reviewed

Kuniyasu Niizuma, Hiroyuki Sakata, Shinya Koyama, Hiroyuki Kon, Masashi Chonan, Tatsuya Sasaki, Michiharu Nishijima, Masayuki Ezura, Teiji Tominaga

Neurological Surgery　40　(11)　1015-1020　2012/11

ISSN： 0301-2603 1882-1251
Induction of thioredoxin-interacting protein is mediated by oxidative stress, calcium, and glucose after brain injury in mice Peer-reviewed

Gab Seok Kim, Joo Eun Jung, Purnima Narasimhan, Hiroyuki Sakata, Pak H. Chan

NEUROBIOLOGY OF DISEASE　46　(2)　440-449　2012/05

DOI： 10.1016/j.nbd.2012.02.008 　

ISSN： 0969-9961
Release of mitochondrial apoptogenic factors and cell death are mediated by CK2 and NADPH oxidase Peer-reviewed

Gab Seok Kim, Joo Eun Jung, Purnima Narasimhan, Hiroyuki Sakata, Hideyuki Yoshioka, Yun Seon Song, Nobuya Okami, Pak H. Chan

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　32　(4)　720-730　2012/04

DOI： 10.1038/jcbfm.2011.176 　

ISSN： 0271-678X
Oxidative Stress and Mitochondrial Dysfunction in Neurovascular Injury After Stroke. Peer-reviewed

Hideyuki YOSHIOKA, Sakata H, Okami N, Hiroyuki KINOUCHI, Chan PH

Jpn J Neurosurg　20　(8)　559-565　2011/08/01
Publisher: The Japanese Congress of Neurological Surgeons
ISSN： 0917-950X

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Effective stroke therapies require recanalization of occluded cerebral blood vessels. However, reperfusion can cause neurovascular injury, leading to cerebral edema, brain hemorrhage, and neuronal death by apoptosis/necrosis. These complications of reperfusion, which result from excess production of reactive oxygen species (ROS), significantly limit the benefits of stroke therapies. We recently found two novel targets for neurovascular protection after ischemia/reperfusion: the signal transducer and activator of transcription 3 (STAT3) pathway and NADPH oxidase (NOX). Manganese-superoxide dismutase (SOD2) plays a critical role in neurovascular injury as a first-line defense against ROS produced in mitochondria, and STAT3 is a major transcriptional factor of the SOD2 gene. During reperfusion, activation of STAT3 and its recruitment into the SOD2 gene are blocked, resulting in increased oxidative stress and neuronal apoptosis. Pharmacological activation of STAT3 with interleukin-6 induces SOD2 expression, which limits ischemic neuronal death. In contrast, NOX is a pro-oxidant multi-subunit enzyme. After ischemia/reperfusion, NOX in the neurovascular unit forms an activated complex to generate ROS, which induce oxidative injury in the neurovascular unit. Pharmacological and genetic inhibition of NOX is neuroprotective against cerebral ischemia/reperfusion. Superoxide dismutase and NOX regulate ROS production in the ischemic brain, interacting with each other in a Yin and Yang relationship. Our neurovascular protective strategies targeting these two enzymes may expand the therapeutic window of the currently approved therapies.
Oxidative Stress in Ischemic Brain Damage: Mechanisms of Cell Death and Potential Molecular Targets for Neuroprotection Peer-reviewed

Hai Chen, Hideyuki Yoshioka, Gab Seok Kim, Joo Eun Jung, Nobuya Okami, Hiroyuki Sakata, Carolina M. Maier, Purnima Narasimhan, Christina E. Goeders, Pak H. Chan

ANTIOXIDANTS & REDOX SIGNALING　14　(8)　1505-1517　2011/04

DOI： 10.1089/ars.2010.3576 　

ISSN： 1523-0864
Consistent Injury to Medium Spiny Neurons and White Matter in the Mouse Striatum after Prolonged Transient Global Cerebral Ischemia Peer-reviewed

Hideyuki Yoshioka, Kuniyasu Niizuma, Masataka Katsu, Hiroyuki Sakata, Nobuya Okami, Pak H. Chan

JOURNAL OF NEUROTRAUMA　28　(4)　649-660　2011/04

DOI： 10.1089/neu.2010.1662 　

ISSN： 0897-7151
NADPH oxidase mediates striatal neuronal injury after transient global cerebral ischemia Peer-reviewed

Hideyuki Yoshioka, Kuniyasu Niizuma, Masataka Katsu, Nobuya Okami, Hiroyuki Sakata, Gab Seok Kim, Purnima Narasimhan, Pak H. Chan

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　31　(3)　868-880　2011/03

DOI： 10.1038/jcbfm.2010.166 　

ISSN： 0271-678X
Hemoglobin-induced oxidative stress contributes to matrix metalloproteinase activation and blood-brain barrier dysfunction in vivo Peer-reviewed

Masataka Katsu, Kuniyasu Niizuma, Hideyuki Yoshioka, Nobuya Okami, Hiroyuki Sakata, Pak H. Chan

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　30　(12)　1939-1950　2010/12

DOI： 10.1038/jcbfm.2010.45 　

ISSN： 0271-678X
Reperfusion and Neurovascular Dysfunction in Stroke: from Basic Mechanisms to Potential Strategies for Neuroprotection Peer-reviewed

Joo Eun Jung, Gab Seok Kim, Hai Chen, Carolina M. Maier, Purnima Narasimhan, Yun Seon Song, Kuniyasu Niizuma, Masataka Katsu, Nobuya Okami, Hideyuki Yoshioka, Hiroyuki Sakata, Christina E. Goeders, Pak H. Chan

MOLECULAR NEUROBIOLOGY　41　(2-3)　172-179　2010/06

DOI： 10.1007/s12035-010-8102-z 　

ISSN： 0893-7648
Serial Angiography of Dynamic Changes of Traumatic Middle Meningeal Arteriovenous Fistula-Case Report Peer-reviewed

Hiroyuki Sakata, Shinjitsu Nishimura, Masaki Mino, Erniko Hori, Tornoaki Fujita, Hiroshi Midorikawa, Mitsuomi Kaimori, Michiharu Nishijima

NEUROLOGIA MEDICO-CHIRURGICA　49　(10)　462-464　2009/10

DOI： 10.2176/nmc.49.462 　

ISSN： 0470-8105
Choice of Intentional Partial Coiling for a Ruptured Intracranial Aneurysm in the Acute Stage Followed by Clipping in the Chronic Stage Peer-reviewed

Shinjitsu Nishimura, Tomoaki Fujita, Hiroyuki Sakata, Emiko Hori, Masaki Mino, Michiharu Nishijima, Hiroshi Midorikawa

NEUROLOGICAL SURGERY　37　(8)　757-763　2009/08

ISSN： 0301-2603
A Successful Surgical Case of a Hypothalamic Hamartoma with Gelastic Seizure: A Case Report Peer-reviewed

Tomoaki Fujita, Shinjitsu Nishimura, Hiroyuki Sakata, Yuichi Furuno, Masaki Mino, Emiko Hori, Mitsuomi Kaimori, Reizou Shirane, Michiharu Nishijima

NEUROLOGICAL SURGERY　37　(8)　781-785　2009/08

ISSN： 0301-2603
The Importance of Telemedicine Using an Image Transfer System in the Case of Aneurysmal Subarachnoid Hemorrhage

HORI Emiko, NISHIMURA Shinjitsu, MINO Masaki, FUJITA Tomoaki, SAKATA Hiroyuki, NISHIJIMA Michiharu, Emiko HORI, Shinjitsu NISHIMURA, Masaki MINO, Tomoaki FUJITA, Hiroyuki SAKATA, Michiharu NISHIJIMA, Department of Neurosurgery Aomori Prefectural Hospital, Department of Neurosurgery Aomori Prefectural Hospital, Department of Neurosurgery Aomori Prefectural Hospital, Department of Neurosurgery Aomori Prefectural Hospital, Department of Neurosurgery Aomori Prefectural Hospital, Department of Neurosurgery Aomori Prefectural Hospital

Nosotchu no Geka Kenkyukai koenshu　37　(1)　26-29　2009/01/31
Publisher: The Japanese Society on Surgery for Cerebral Stroke
DOI： 10.2335/scs.37.26 　

ISSN： 0914-5508

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Our department is located in the Tsugaru area of Aomori Prefecture, which has a population of about 600,000. There are few neurosurgical centers that can treat patients presenting with stroke, head trauma, and other disorders. In this report, we describe the usefulness of telemedicine using an imaging transfer system for aneurysmal subarachnoid hemorrhage. Imaging transfer systems have been installed at our hospital and 11 regional hospitals in the Tsugaru area. We studied 572 patients with subarachnoid hemorrhage who transferred using the imaging transfer system and admitted directly from January 2001 to August 2007. We studied Hunt and Kosnik grade on admission, treatment, Glasgow outcome scale, and the place of re-rupture. Most patients were transferred and treated with direct surgery and endovascular embolization in the telemedicine group. In the telemedicine group, Hunt and Kosnik grade and Glasgow outcome scale were significantly better than in the direct-admission group. Re-rupture was suspected in 38 cases (6.6%). And 71.4% of re-ruptures occurred in an ambulance in the direct-admission group. On the other hand, in the telemedicine group 42.9% of re-ruptures occurred during transport to the primary hospital and during transfer from the primary hospital to our hospital. There were not many severe patients in the telemedicine group compared with the direct-admission group. The final outcome in the telemedicine group was better than in the direct-admission group. These findings indicate that telemedicine using an image transfer system is useful in the treatment of subarachnoid hemorrhage.
Medulloblastoma demonstrating multipotent differentiation: case report Peer-reviewed

Hiroyuki Sakata, Masayuki Kanamori, Mika Watanabe, Toshihiro Kumabe, Teiji Tominaga

BRAIN TUMOR PATHOLOGY　25　(1)　39-43　2008/04

DOI： 10.1007/s10014-007-0228-y 　

ISSN： 1433-7398
Neurenteric cyst of the craniocervical junction in an infant Peer-reviewed

Hiroyuki Sakata, Miki Fujimura, Masaki Iwasaki, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　48　(2)　86-89　2008/02

DOI： 10.2176/nmc.48.86 　

ISSN： 0470-8105
破裂小型脳動脈瘤の2手術例

坂田洋之, 清水宏明, 岩崎真樹, 藤原悟, 冨永悌二

東北脳血管障害研究会学術集会記録集　29回　67-70　2007/12
Publisher: サノフィ(株)仙台オフィス
ISSN： 1880-9278

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症例1(48歳女性)。突然の頭痛と嘔気で近医を受診、CTにてくも膜下出血を指摘され、著者らの施設へ緊急搬送された。CTでは非限局性のくも膜下出血がみられ、3次元脳血管撮影(3D-DSA)では左交通動脈瘤(長径1.5mm)を認めた。開頭によるクリッピング術を行ったところ、術後は症候性スパスムもなく経過し、DSAで動脈瘤の残存なしを確認後、退院となった。症例2(58歳男性)。突然の後頭部痛と嘔気で救急搬送された。CTでは大脳半球間裂を含むくも膜下出血が認められ、DSAでは前交通動脈に前向き5mm、後向き1.5mmと2mmの計3個の動脈瘤が確認された。開頭によるクリッピング術を行ったところ、前向き5mmの動脈瘤は未破裂であったがクリッピングを行い、後向き2mmの動脈瘤は未破裂で穿通枝に囲まれていたためクリッピングを断念し、1.5mmの動脈瘤は易出血性で破裂動脈瘤と判断、クリッピングを行った。その結果、術後は症候性スパスムもなく経過し、DSAにて動脈瘤の残存なしを確認後、退院となった。
Association of cavernous malformation within vestibular schwannoma: Immunohistochemical analysis of matrix metalloproteinase-2 and-9 - Case report Peer-reviewed

Hiroyuki Sakata, Miki Fujimura, Mika Watanabe, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　47　(11)　509-512　2007/11

DOI： 10.2176/nmc.47.509 　

ISSN： 0470-8105
Static progression of pediatric malignant brain tumors with metastases Peer-reviewed

Hiroyuki Sakata

CYRIC Annual Report.　2007　113-117　2007
Publisher: Cyclotron and Radioisotope Center, Tohoku University
Analysis of mutation spectra in UVB-exposed mouse skin epidermis and dermis: Frequent occurrence of C -> T transition at methylated CpG-associated dipyrimidine sites Peer-reviewed

H Ikehata, T Masuda, H Sakata, T Ono

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS　41　(4)　280-292　2003

DOI： 10.1002/em.10153 　

ISSN： 0893-6692

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Misc. 154

破裂脳動脈瘤治療におけるMRI瘤壁造影効果の有用性-VWIによる破裂部位・破裂点同定と診断ピットフォール克服-

面高俊介, 鹿毛淳史, 坂田洋之, 遠藤英徳

日本脳神経CI学会総会プログラム・抄録集　49th　2026
未破裂脳動脈瘤に対する血管内治療における脳梗塞発生危険因子の検討

佐野顕史, 面高俊介, 坂田洋之, 佐藤吉通, 内田浩喜, 鹿毛淳史, 園田順彦, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　41回　430-430　2025/11
Publisher: (一社)日本脳神経血管内治療学会
eISSN： 2759-6907
破裂内頸動脈血豆状動脈瘤治療における虚血性合併症の検討

鹿毛淳史, 内田浩喜, 坂田洋之, 田代亮介, 佐藤吉通, 面高俊介, 新妻邦泰, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　41回　451-451　2025/11
Publisher: (一社)日本脳神経血管内治療学会
eISSN： 2759-6907
前方循環系頭蓋内主幹動脈狭窄症の臨床像と狭窄進行のバイオマーカー探索

田代亮介, 鹿毛淳史, 面高俊介, 矢澤由加子, 坂田洋之, 井上智夫, 臼杵豊展, 新妻邦泰, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　41回　649-649　2025/11
Publisher: (一社)日本脳神経血管内治療学会
eISSN： 2759-6907
ステント支援下コイル塞栓術後に再発を来した脳動脈瘤に対するFlow Diverterの有効性・安全性

佐藤吉通, 坂田洋之, 田代亮介, 鹿毛淳史, 面高俊介, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　41回　747-747　2025/11
Publisher: (一社)日本脳神経血管内治療学会
eISSN： 2759-6907
フローダイバーターステントSurpass Evolveの中期治療成績 Streamlineとの比較

面高俊介, 坂田洋之, 松本康史, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　41回　749-749　2025/11
Publisher: (一社)日本脳神経血管内治療学会
eISSN： 2759-6907
母血管が高度に屈曲した紡錘状動脈瘤に対してFlow Diverter Stent留置後にステント内閉塞に至った一例

真貝勇斗, 面高俊介, 田代亮介, 坂田洋之, 鹿毛淳史

日本脳神経血管内治療学会学術集会抄録集　41回　783-783　2025/11
Publisher: (一社)日本脳神経血管内治療学会
eISSN： 2759-6907
未破裂脳動脈瘤に対する血管内治療における脳梗塞発生危険因子の検討

佐野顕史, 面高俊介, 坂田洋之, 佐藤吉通, 内田浩喜, 鹿毛淳史, 園田順彦, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　41回　430-430　2025/11
Publisher: (一社)日本脳神経血管内治療学会
eISSN： 2759-6907
破裂内頸動脈血豆状動脈瘤治療における虚血性合併症の検討

鹿毛淳史, 内田浩喜, 坂田洋之, 田代亮介, 佐藤吉通, 面高俊介, 新妻邦泰, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　41回　451-451　2025/11
Publisher: (一社)日本脳神経血管内治療学会
eISSN： 2759-6907
前方循環系頭蓋内主幹動脈狭窄症の臨床像と狭窄進行のバイオマーカー探索

田代亮介, 鹿毛淳史, 面高俊介, 矢澤由加子, 坂田洋之, 井上智夫, 臼杵豊展, 新妻邦泰, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　41回　649-649　2025/11
Publisher: (一社)日本脳神経血管内治療学会
eISSN： 2759-6907
ステント支援下コイル塞栓術後に再発を来した脳動脈瘤に対するFlow Diverterの有効性・安全性

佐藤吉通, 坂田洋之, 田代亮介, 鹿毛淳史, 面高俊介, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　41回　747-747　2025/11
Publisher: (一社)日本脳神経血管内治療学会
eISSN： 2759-6907
フローダイバーターステントSurpass Evolveの中期治療成績 Streamlineとの比較

面高俊介, 坂田洋之, 松本康史, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　41回　749-749　2025/11
Publisher: (一社)日本脳神経血管内治療学会
eISSN： 2759-6907
母血管が高度に屈曲した紡錘状動脈瘤に対してFlow Diverter Stent留置後にステント内閉塞に至った一例

真貝勇斗, 面高俊介, 田代亮介, 坂田洋之, 鹿毛淳史

日本脳神経血管内治療学会学術集会抄録集　41回　783-783　2025/11
Publisher: (一社)日本脳神経血管内治療学会
eISSN： 2759-6907
もやもや病患者における糞便中Lactococcus lactisの欠乏と短鎖脂肪酸の変化

大友真優子, 田代亮介, 徳野秀尚, 鹿毛淳史, 冨永慶太, 永井新, 相川亨, 安藤大祐, 坂田洋之, 佐藤岳哉, 冨永悌二, 阿部高明, 新妻邦泰, 遠藤英徳

脳循環代謝　37　(1)　89-89　2025/10
Publisher: (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
もやもや病患者における糞便中Lactococcus lactisの欠乏と短鎖脂肪酸の変化

大友真優子, 田代亮介, 徳野秀尚, 鹿毛淳史, 冨永慶太, 永井新, 相川亨, 安藤大祐, 坂田洋之, 佐藤岳哉, 冨永悌二, 阿部高明, 新妻邦泰, 遠藤英徳

脳循環代謝　37　(1)　89-89　2025/10
Publisher: (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
くも膜下出血術後管理におけるクラゾセンタンのリアルワールドデータ

遠藤英徳, 坂田洋之, 鹿毛淳史, 内田浩喜, 面高俊介, 新妻邦泰

くも膜下出血と脳血管攣縮　39-40　81-81　2025/06
Publisher: SAH
ISSN： 2759-2405
もやもや病高齢者もやもや病の病態と血行再建術

鹿毛淳史, 内田浩喜, 田代亮介, 坂田洋之, 新妻邦泰, 遠藤英徳

脳循環代謝　36　(1)　68-68　2024/11
Publisher: (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
フローダイバーター治療戦略のパラダイムシフト DSAを用いた脳循環解析による術中動脈瘤閉塞予測

坂田洋之, 針生新也, 田代亮介, 鹿毛浩喜, 遠藤英徳

脳循環代謝　36　(1)　80-80　2024/11
Publisher: (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
頸動脈ステント留置術後過灌流予防のためのエダラボン術前投与

井上敬, 大友智, 庄司薫, 佐藤健一, 坂田洋之, 遠藤英徳

脳循環代謝　36　(1)　107-107　2024/11
Publisher: (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
術前・術中画像診断に基づく戦略的血栓回収療法

坂田洋之, 坂田洋之, 佐藤健一, 江面正幸, 矢澤由加子, 遠藤英徳

日本血管内治療学会学術総会プログラム・抄録集　30th　2024
The microsurgery for spheno-orbital meningioma: two case reports

内田浩喜, 面高俊介, 鹿毛淳史, 坂田洋之, 川口奉洋, 遠藤英徳

日本頭蓋底外科学会プログラム・抄録集　36th　2024
高齢者もやもや病の病態と血行再建術

鹿毛淳史, 内田浩喜, 田代亮介, 坂田洋之, 新妻邦泰, 新妻邦泰, 遠藤英徳

脳循環代謝(Web)　36　(1)　2024

ISSN： 2188-7519
頚動脈ステント留置術後過灌流予防のためのエダラボン術前投与

井上敬, 大友智, 庄司薫, 佐藤健一, 坂田洋之, 遠藤英徳

脳循環代謝(Web)　36　(1)　2024

ISSN： 2188-7519
フローダイバーター治療戦略のパラダイムシフト:DSAを用いた脳循環解析による術中動脈瘤閉塞予測

坂田洋之, 坂田洋之, 針生新也, 田代亮介, 鹿毛淳史, 内田浩喜, 遠藤英徳

脳循環代謝(Web)　36　(1)　2024

ISSN： 2188-7519
pituitary neuroendocrine tumor concomittant with internal carotid artery agenesis

田代亮介, 川口奉洋, 石田朋久, 坂田洋之, 和泉健大龍, 渡邊裕文, 渡邊みか, 遠藤英徳

日本神経内視鏡学会プログラム・抄録集　31st　2024
endoscopic microvascular decompression to hemifacial spasm

内田浩喜, 川口奉洋, 田代亮介, 鹿毛淳史, 坂田洋之, 遠藤英徳

日本神経内視鏡学会プログラム・抄録集　31st　2024
エダラボン術前投与による頚動脈ステント留置術後過灌流予防

井上敬, 大友智, 庄司薫, 佐藤健一, 坂田洋之, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集(Web)　40th　2024

ISSN： 2759-6907
働き方改革大奮闘中!

矢澤由加子, 鹿毛淳史, 坂田洋之

日本脳神経血管内治療学会学術集会抄録集(Web)　40th　2024

ISSN： 2759-6907
手技訓練用シミュレータにおける表面粗さと硬さが操作感に及ぼす影響

長谷川理子, 小助川博之, 于凱鴻, 新妻邦泰, 坂田洋之, 庄島正明, 松本康史, 坂井信幸, 太田信

日本脳神経血管内治療学会学術集会抄録集(Web)　40th　2024

ISSN： 2759-6907
後方循環系のアテローム血栓性脳梗塞患者のうち入院後に症状が悪化し急性期血行再建術(血管形成術)を要する症例の特徴

川端雄一, 八木橋崇仁, 深谷浩史, 坂田洋之

日本脳神経血管内治療学会学術集会抄録集(Web)　40th　2024

ISSN： 2759-6907
フローダイバーター治療戦略のパラダイムシフト:DSAを用いた脳循環解析による術中動脈瘤閉塞予測

坂田洋之, 坂田洋之, 針生新也, 田代亮介, 田代亮介, 鹿毛敦史, 内田浩喜, 松本康史, 松本康史, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集(Web)　40th　2024

ISSN： 2759-6907
Endovascular treatment of brain arteriovenous malformations

坂田洋之, 坂田洋之, 遠藤英徳

医学のあゆみ　291　(7)　2024

ISSN： 0039-2359
Staged angioplastyの2回ともステント留置を施行した一例

田代亮介, 佐藤健一, 坂田洋之, 岩渕直也, 長田佳整, 江面正幸

Mt. Fuji Workshop on CVD　41st　2024

ISSN： 0289-8438
頸動脈ステント留置術における当院の抗血小板療法レジメンの成績

川端雄一, 八木橋崇仁, 深谷浩史, 眞野唯, 新保大輔, 坂田洋之, 矢澤由加子

脳血管内治療　8　(Suppl.)　S217-S217　2023/11
Publisher: (一社)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
three dimensional digital subtraction angiographyを使用した脳血管径解析

八木橋崇仁, 深谷浩史, 千葉朋浩, 眞野唯, 新保大輔, 川端雄一, 坂田洋之, 矢澤由加子

脳血管内治療　8　(Suppl.)　S862-S862　2023/11
Publisher: (一社)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
血管内治療 02)未破裂脳動脈瘤のコイル塞栓術

坂田洋之

Brain Nursing　39　(1)　2023

ISSN： 0910-8459
複雑なトルコ鞍近傍腫瘍に対する栄養動脈塞栓術の有効性と限界

川口奉洋, 石田朋久, 鹿毛淳史, 遠藤英徳, 坂田洋之, 小川欣一, 冨永悌二

日本間脳下垂体腫瘍学会プログラム・抄録集　33rd　2023
クラゾセンタン単剤プロトコール導入によるくも膜下出血術後管理

遠藤英徳, 坂田洋之, 鹿毛淳史, 内田浩喜, 面高俊介, 新妻邦泰

脳循環代謝(Web)　35　(1)　2023

ISSN： 2188-7519
脳動脈瘤出血点予測における瘤壁造影効果の有用性

面高俊介, 坂田洋之, 杉山慎一郎, 新妻邦泰, 遠藤英徳

脳循環代謝(Web)　35　(1)　2023

ISSN： 2188-7519
てんかん発作時と非発作時の脳血管撮影所見の比較

油川大輝, 油川大輝, 鹿毛淳史, 内田浩喜, 川口奉洋, 坂田洋之, 鈴木一郎, 遠藤英徳

脳循環代謝(Web)　35　(1)　2023

ISSN： 2188-7519
チマメ状動脈瘤破裂によるくも膜下出血に対するhigh flow bypass後の血行動態

鹿毛淳史, 内田浩喜, 坂田洋之, 新妻邦泰, 新妻邦泰, 遠藤英徳

脳循環代謝(Web)　35　(1)　2023

ISSN： 2188-7519
複数回の血管内再治療を要した放射線誘発頚動脈狭窄症の2例

内田浩喜, 鹿毛淳史, 矢澤由加子, 坂田洋之, 坂田洋之, 松本康史, 新妻邦泰, 遠藤英徳

脳循環代謝(Web)　35　(1)　2023

ISSN： 2188-7519
動眼神経麻痺で発症した未破裂内頚動脈-後交通動脈分岐部動脈瘤の瘤壁造影効果

面高俊介, 坂田洋之, 新妻邦泰, 松本康史, 遠藤英徳

脳血管内治療(Web)　8　(Supplement)　2023

ISSN： 2424-1709
内頚動脈後交通動脈分岐部動脈瘤に対する血管内治療:vessel wall imagingによる難治例予測と治療戦略の提唱

坂田洋之, 坂田洋之, 内田浩喜, 眞野唯, 鹿毛淳史, 新保大輔, 松本康史, 遠藤英徳

脳血管内治療(Web)　8　(Supplement)　2023

ISSN： 2424-1709
中大脳動脈瘤治療における瘤壁造影効果と虚血性合併症の関連

鹿毛淳史, 坂田洋之, 内田浩喜, 面高俊介, 新妻邦泰, 新妻邦泰, 松本康史, 遠藤英徳

脳血管内治療(Web)　8　(Supplement)　2023

ISSN： 2424-1709
頚動脈ステント留置術における当院の抗血小板療法レジメンの成績

川端雄一, 八木橋崇仁, 深谷浩史, 眞野唯, 新保大輔, 坂田洋之, 矢澤由加子

脳血管内治療(Web)　8　(Supplement)　2023

ISSN： 2424-1709
教師なし学習によるIC-Pcom動脈瘤の形態的クラスタリング-血管内治療後の再発との関係性-

内田浩喜, 杉山慎一郎, 鹿毛淳史, 坂田洋之, 坂田洋之, 遠藤英徳

脳血管内治療(Web)　8　(Supplement)　2023

ISSN： 2424-1709
大型動脈瘤に対するFlow Diverterによる治療成績:vessel wall imagingによる難治例の予測は可能か

新保大輔, 坂田洋之, 坂田洋之, 眞野唯, 鹿毛淳史, 内田浩喜, 松本康史, 藤村幹, 遠藤英徳

脳血管内治療(Web)　8　(Supplement)　2023

ISSN： 2424-1709
three dimensional digital subtraction angiographyを使用した脳血管径解析

八木橋崇仁, 深谷浩史, 千葉朋浩, 眞野唯, 新保大輔, 川端雄一, 坂田洋之, 矢澤由加子

脳血管内治療(Web)　8　(Supplement)　2023

ISSN： 2424-1709
SHAP(SHapley Additive exPlanations)解析によるCEA/CASの決定過程の可視化

内田浩喜, 鹿毛淳史, 面高俊介, 坂田洋之, 坂田洋之, 遠藤英徳

脳血管内治療(Web)　8　(Supplement)　2023

ISSN： 2424-1709
staged angioplastyの2回ともステント留置を要した頚部内頚動脈狭窄症の2例

田代亮介, 佐藤健一, 坂田洋之, 岩渕直也, 長田佳整, 江面正幸

脳血管内治療(Web)　8　(Supplement)　2023

ISSN： 2424-1709
【どんな手術が、どんな手順で、どんな風に行われているかがとことんわかる!手術動画つき必要な術後看護がみえてくる脳神経外科の手術】(2章)脳神経外科の実際の手術と術後看護血管内治療未破裂脳動脈瘤のコイル塞栓術

坂田洋之

Brain Nursing　39　(1)　87-90　2023/01
Publisher: (株)メディカ出版
ISSN： 0910-8459
Efficacy of indocyanine green fluorescence endoscopy for the treatment strategy of craniocervical junction arteriovenous fistula with ventaral lesion: A case report

石田朋久, 石田朋久, 川口奉洋, 鹿毛淳史, 坂田洋之, 遠藤英徳

日本神経内視鏡学会プログラム・抄録集　30th　2023
術前・術中画像診断に基づく戦略的血栓回収療法

坂田洋之, 遠藤英徳, 矢澤由加子, 冨永悌二

日本血管内治療学会学術総会プログラム・抄録集　29th　2023
医療関係者間コミュニケーションアプリJoinの当院での活用状況

江面正幸, 坂田洋之, 梶谷卓未, 油川大輝, 大沢昌二, 上之原広司

国立病院総合医学会講演抄録集　76回　582-582　2022/10
Publisher: 国立病院総合医学会
特集1 絶対苦手分野にしない脳梗塞の画像診断急性期脳梗塞の治療−機械的血栓回収療法を前提とした画像検査の実際−

江面正幸, 坂田洋之, 上之原広司

臨床画像　38　(3)　312-320　2022/03/26
Publisher: メジカルビュー社
DOI： 10.18885/ci.0000000874 　

ISSN： 0911-1069
最大径12mm未満の硬膜内内頚動脈瘤に対するフローダイバーター留置術

江面正幸, 坂田洋之, 斉藤敦志, 上之原広司

日本神経放射線学会プログラム・抄録集　51st　2022
充実性小脳血管芽腫の発生部位に基づく手術戦略

村上謙介, 佐藤健一, 水野敬悟, 坂田洋之, 井上智夫, 下田由輝, 冨永悌二

日本脳腫瘍の外科学会プログラム・抄録集　27th　2022
頭蓋内アテローム性動脈硬化症に対する急性期血行再建術の治療戦略:stenting without retrieval法の提唱

坂田洋之, 江面正幸, 長田佳整, 斉藤敦志, 上之原広司, 冨永悌二

脳循環代謝(Web)　34　(1)　2022

ISSN： 2188-7519
Novel strategy of endovascular revascularization for acute ischemic stroke due tointracranial atherosclerosis

坂田洋之, 江面正幸, 長田佳整, 斉藤敦志, 上之原広司, 冨永悌二

脳血管内治療(Web)　7　(Supplement)　2022

ISSN： 2424-1709
脳卒中METの起動により血栓回収術を行った肺癌術後の院内発症内頚動脈塞栓症の1例

井上学, 江面正幸, 本多赳善, 永井友仁, 長田佳整, 坂田洋之, 斉藤敦志, 上之原広司, 羽隅透

仙台医療センター医学雑誌(Web)　12　(3)　2022

ISSN： 2186-0920
コイル塞栓術後慢性期に開頭クリッピング術を施行した症例の特徴

井上敬, 江面正幸, 坂田洋之, 大友智, 上之原広司, 冨永悌二

脳血管内治療　6　(Suppl.)　S244-S244　2021/11
Publisher: (一社)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
治療前CT画像による血栓性状診断:血栓回収療法の新たな治療戦略の提唱

坂田洋之, 江面正幸, 石田朋久, 斉藤敦志, 遠藤英徳, 上之原広司, 冨永悌二

脳循環代謝(Web)　33　(1)　2021

ISSN： 2188-7519
Therapeutic strategy of mechanical thrombectomy based on the thrombus imaging characteristics

坂田洋之, 江面正幸, 石田朋久, 斉藤敦志, 遠藤英徳, 上之原広司, 冨永悌二

脳血管内治療(Web)　6　(Supplement)　2021

ISSN： 2424-1709
Clinical feature of aneurysms clipped after coil embolization

井上敬, 江面正幸, 坂田洋之, 大友智, 上之原広司, 冨永悌二

脳血管内治療(Web)　6　(Supplement)　2021

ISSN： 2424-1709
CEA術中ICGによる術後過灌流予測

井上敬, 石田朋久, 坂田洋之, 遠藤英徳, 江面正幸, 上之原広司, 齋藤敦志, 新妻邦泰, 冨永梯二

日本脳神経CI学会総会プログラム・抄録集　44th　2021
Mechanical thrombectomy for elderly patients with acute ischemic stroke

坂田洋之, 江面正幸, 石田朋久, 遠藤英徳, 井上敬, 斉藤敦志, 上之原広司, 冨永悌二

Geriatric Neurosurgery (Web)　34　2021

ISSN： 2436-6064
【ナースが知りたい脳神経外科手術とケアのポイント】(chapter2)脳血管内治療とケアのポイント脳動静脈奇形塞栓術

坂田洋之, 遠藤俊毅

Brain Nursing　(2020春季増刊)　119-126　2020/02
Publisher: (株)メディカ出版
ISSN： 0910-8459
健康長寿を達成するための明日への取り組み-脳血管内治療科の立場から-

江面正幸, 坂田洋之, 井上敬, 遠藤英徳, 上之原広司

日本臨床医療福祉学会プログラム・抄録集　18th　2020
Fetal typeの内頚動脈後交通動脈分岐部動脈瘤に対するコイル塞栓術

江面正幸, 坂田洋之, 井上敬, 上之原広司

日本神経放射線学会プログラム・抄録集　49th　2020
脳動脈瘤は無症候性脳梗塞発症のリスクファクター

井上敬, 遠藤英徳, 坂田洋之, 石田朋久, 江面正幸, 上之原広司, 冨永悌二

脳循環代謝(Web)　32　(1)　2020

ISSN： 2188-7519
2D perfusion angiographyを用いた頚動脈ステント留置術後の過灌流予測

坂田洋之, 江面正幸, 石田朋久, 阿部考貢, 井上敬, 遠藤英徳, 遠藤俊毅, 上之原広司, 冨永悌二

脳循環代謝(Web)　32　(1)　2020

ISSN： 2188-7519
Intraaneurysmal Neck Plasty-スーパーコンプライアントダブルルーメンバルーンカテーテルを用いた方法-

江面正幸, 木村尚人, 坂田洋之, 石田朋久, 井上敬, 上之原広司

脳血管内治療(Web)　5　(Supplement)　2020

ISSN： 2424-1709
2D perfusion angiographyを用いた頚動脈ステント留置術後の過灌流予測

坂田洋之, 江面正幸, 阿部考貢, 石田朋久, 井上敬, 遠藤英徳, 遠藤俊毅, 遠藤俊毅, 冨永悌二

脳血管内治療(Web)　5　(Supplement)　2020

ISSN： 2424-1709
頚動脈ステント留置術後の過灌流に対するミノサイクリン塩酸塩を用いた周術期管理

坂田洋之, 江面正幸, 石田朋久, 阿部考貢, 井上敬, 遠藤英徳, 冨永悌二

脳血管内治療(Web)　5　(Supplement)　2020

ISSN： 2424-1709
【わかった!につながるコアスタディ脳卒中患者さんを看るためにだいじな動脈10】椎骨動脈と後下小脳動脈

坂田洋之

Brain Nursing　35　(11)　1050-1053　2019/11
Publisher: (株)メディカ出版
ISSN： 0910-8459
CASを第一選択とした頸部内頸動脈狭窄症の周術期治療成績

坂田洋之, 江面正幸, 井上敬, 上之原広司

脳血管内治療　4　(Suppl.)　S156-S156　2019/11
Publisher: (一社)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
頭蓋外内頸動脈解離からの遠位塞栓による中大脳動脈閉塞を来したEagle症候群に対する急性期血行再建術一例

井上智夫, 江面正幸, 西嶌泰生, 井上敬, 坂田洋之, 上之原広司, 冨永悌二

脳血管内治療　4　(Suppl.)　S374-S374　2019/11
Publisher: (一社)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
脳血管内撮影におけるフローダイバーターステント留置後の画像経過観察

鎌田俊亮, 佐久間教之, 高橋大樹, 坂田洋之, 江面正幸

脳血管内治療　4　(Suppl.)　S396-S396　2019/11
Publisher: (一社)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
CASを第一選択とした頸部内頸動脈狭窄症の周術期治療成績

坂田洋之, 江面正幸, 井上敬, 上之原広司, 冨永悌二

脳循環代謝　31　(1)　115-115　2019/11
Publisher: (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
外科的血行再建と脳循環術中ICGによるCEA術後過灌流予測

井上敬, 坂田洋之, 井上智夫, 江面正幸, 上之原広司, 斉藤敦志, 藤村幹, 遠藤英徳, 新妻邦泰, 冨永悌二

脳循環代謝　31　(1)　88-88　2019/11
Publisher: (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
CASを第一選択とした頚部内頚動脈狭窄症の周術期治療成績

坂田洋之, 江面正幸, 井上敬, 上之原広司, 冨永悌二

脳循環代謝(Web)　31　(1)　2019

ISSN： 2188-7519
脳血管内撮影におけるフローダイバーターステント留置後の画像経過観察

鎌田俊亮, 佐久間教之, 高橋大樹, 坂田洋之, 江面正幸

脳血管内治療(Web)　4　(Supplement)　2019

ISSN： 2424-1709
頭蓋外内頚動脈解離からの遠位塞栓による中大脳動脈閉塞を来したEagle症候群に対する急性期血行再建術一例

井上智夫, 江面正幸, 西嶌泰生, 井上敬, 坂田洋之, 上之原広司, 冨永悌二

脳血管内治療(Web)　4　(Supplement)　2019

ISSN： 2424-1709
CASを第一選択とした頚部内頚動脈狭窄症の周術期治療成績

坂田洋之, 江面正幸, 井上敬, 上之原広司

脳血管内治療(Web)　4　(Supplement)　2019

ISSN： 2424-1709
術中ICGによるCEA術後過灌流予測

井上敬, 坂田洋之, 井上智夫, 江面正幸, 上之原広司, 斉藤敦志, 藤村幹, 遠藤英徳, 新妻邦泰, 冨永悌二

脳循環代謝(Web)　31　(1)　2019

ISSN： 2188-7519
ACST2参加施設における外科的治療の現状

江面正幸, 坂田洋之, 井上敬, 上之原広司

日本心血管脳卒中学会学術集会プログラム・抄録集　6th　2019
部分血栓化脳動脈瘤を塞栓源とした塞栓性脳梗塞の一例

後藤悠樹, 張替宗介, 船山由希乃, 結城翼, 中村貴彬, 菅谷涼, 川崎永美子, 渡辺源也, 突田健一, 鈴木靖士, 坂田洋之, 江面正幸

臨床神経学(Web)　59　(11)　2019

ISSN： 1882-0654
エンボスフィアを用いたTAEで根治し得た海綿静脈洞部硬膜動静脈瘻の一治療例

新妻邦泰, 坂田洋之, 大沢伸一郎, 遠藤英徳, 松本康史, 冨永悌二

脳血管内治療　2　(Suppl.)　S204-S204　2017/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119
ラット脳梗塞モデルに対する体性多能性幹細胞(Muse細胞)移植-機能改善と細胞動態の解析-

森田隆弘, 森田隆弘, 内田浩喜, 内田浩喜, 新妻邦泰, 串田良祐, 若尾昌平, 松坂義哉, 坂田洋之, 虫明元, 出澤真理, 冨永悌二

再生医療　16　2017

ISSN： 1347-7919
ラクナ梗塞モデルに対する新規多能性幹細胞(Muse細胞)の治療効果

内田浩喜, 新妻邦泰, 坂田洋之, 藤村幹, 出澤真理, 冨永悌二

日本分子脳神経外科学会プログラム・抄録集　18th　2017
もやもや病に対する直接間接複合血行再建術:頭蓋形成における生体性吸収性プレート併用法の長期成績

藤村幹, 遠藤英徳, 新妻邦泰, 坂田洋之, 冨永悌二

日本整容脳神経外科研究会プログラム・抄録集　10th　2017
脳梗塞に対するchemical preconditioningを用いた細胞移植治療

坂田洋之, 新妻邦泰, 藤村幹, CHAN Pak, 冨永悌二

再生医療　16　2017

ISSN： 1347-7919
エンボスフィアを用いたTAEで根治し得た海綿静脈洞部硬膜動静脈瘻の一治療例

新妻邦泰, 坂田洋之, 大沢伸一郎, 遠藤英徳, 松本康史, 冨永悌二

脳血管内治療(Web)　2　(Supplement)　2017

ISSN： 2424-1709
下垂体腺腫治療後の内頸動脈瘤形成その成因と治療

坂田洋之, 遠藤英徳, 藤村幹, 小川欣一, 城倉英史, 川岸潤, 佐藤健一, 松本康史, 遠藤俊毅, 冨永悌二

東北脳血管障害研究会学術集会記録集　38回　0271-0283　2016/12
Publisher: サノフィ(株)仙台オフィス
ISSN： 1880-9278
虚血発症もやもや病における血管構造上の特徴

坂田洋之, 新妻邦泰, 藤村幹, 冨永悌二

脳循環代謝　28　(1)　180-180　2016/11
Publisher: (一社)日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
Sinus plastyにより認知障害が改善した硬膜動静脈瘻(Cognard type I)の1例皮質静脈逆流を伴わない症例に対する治療適応

坂田洋之, 新妻邦泰, 藤村幹, 松本康史, 冨永悌二

脳血管内治療　1　(Suppl.)　S38-S38　2016/11
Publisher: (一社)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
成人もやもや病に対する直接間接複合バイパス術脳循環画像に基づいた周術期管理の効果とpitfall

藤村幹, 坂田洋之, 新妻邦泰, 遠藤英徳, 井上敬, 冨永悌二

脳循環代謝　28　(1)　182-182　2016/11
Publisher: 日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
QUANTITATIVE MEASUREMENT OF CEREBRAL BLOOD FLOW USING SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY WITH VENOUS BLOOD SAMPLING

T. Inoue, H. Shimizu, M. Fujimura, K. Sato, H. Endo, K. Niizuma, H. Sakata, T. Tominaga

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　36　402-402　2016/06

ISSN： 0271-678X

eISSN： 1559-7016
MOUSE MODEL OF LACUNAR INFARCTS WITH LONG-LASTING FUNCTIONAL DISABILITIES

H. Uchida, K. Niizuma, H. Sakata, M. Fujimura, M. Dezawa, T. Tominaga

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　36　215-215　2016/06

ISSN： 0271-678X

eISSN： 1559-7016
Reperfusion and Neurovascular Dysfunction in Stroke: from Basic Mechanisms to Potential Strategies for Neuroprotection

Joo Eun Jung, Gab Seok Kim, Hai Chen, Carolina M. Maier, Purnima Narasimhan, Yun Seon Song, Kuniyasu Niizuma, Masataka Katsu, Nobuya Okami, Hideyuki Yoshioka, Hiroyuki Sakata, Christina E. Goeders, Pak H. Chan

Mol Neurobiol　41　(2-3)　172-179　2016/06

DOI： 10.1007/s12035-010-8102-z 　

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First Online:17 February 2010
Filum terminale AVMの1例

梶谷卓未, 遠藤俊毅, 坂田洋之, 佐藤健一, 松本康史, 遠藤英徳, 冨永悌二

日本脊髄外科学会プログラム・抄録集　31st　2016
ラット虚血脳モデルを用いた,もやもや病疾患感受性遺伝子Rnf213の転写バリアント発現動態の解析

前田美香, 藤村幹, RASHAD Sherif, 藤村(森田)維子, 新妻邦泰, 坂田洋之, 井川俊太郎, 冨永悌二

日本分子脳神経外科学会プログラム・抄録集　17th　2016
Muse細胞による脳梗塞治療

新妻邦泰, 坂田洋之, 内田浩喜, 森田隆弘, 阿部考貢, 藤村幹, 出澤真理, 冨永悌二

脳循環代謝(Web)　28　(1)　2016

ISSN： 2188-7519
虚血発症もやもや病における血管構造上の特徴

坂田洋之, 新妻邦泰, 藤村幹, 冨永悌二

脳循環代謝(Web)　28　(1)　2016

ISSN： 2188-7519
もやもや病に対する直接間接複合血行再建術:皮切・頭蓋形成の工夫による非神経学的合併症回避の試み

藤村幹, 遠藤英徳, 新妻邦泰, 坂田洋之, 冨永悌二

日本整容脳神経外科研究会プログラム・抄録集　9th　2016
もやもや病に対する直接間接複合血行再建術:皮膚切開・頭蓋形成の工夫による非神経学的合併症回避の試み

藤村幹, 遠藤英徳, 新妻邦泰, 坂田洋之, 冨永悌二

日本整容脳神経外科研究会研究会記録集　9th　2016
成人もやもや病に対する直接間接複合バイパス術:脳循環画像に基づいた周術期管理の効果とpitfall

藤村幹, 坂田洋之, 新妻邦泰, 遠藤英徳, 井上敬, 冨永悌二

脳循環代謝(Web)　28　(1)　2016

ISSN： 2188-7519
Sinus plastyにより認知障害が改善した硬膜動静脈瘻(Cognard type I)の1例:皮質静脈逆流を伴わない症例に対する治療適応

坂田洋之, 新妻邦泰, 藤村幹, 松本康史, 冨永悌二

脳血管内治療(Web)　1　(Supplement)　2016

ISSN： 2424-1709
A case of ruptured infectious anterior cerebral artery aneurysm treated by interposition graft bypass using the superficial temporal artery

Takatsugu Abe, Hidenori Endo, Hiroaki Shimizu, Miki Fujimura, Toshiki Endo, Hiroyuki Sakata, Mika Watanabe, Teiji Tominaga

Surgical Neurology International　7　(1)　2016/01/01
Publisher: Medknow Publications
DOI： 10.4103/2152-7806.173319 　

ISSN： 2152-7806
小児もやもや病に対する直接間接複合バイパス術長期治療成績の検討

藤村幹, ラシャド・シェリフ, 遠藤英徳, 新妻邦泰, 坂田洋之, 佐藤健一, 冨永悌二

脳循環代謝　27　(1)　139-139　2015/10
Publisher: 日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
深部脳動静脈奇形周囲にcerebral proliferative angiopathyの2次的形成を認めた小児例

坂田洋之, 藤村幹, 佐藤健一, 新妻邦泰, 遠藤英徳, 冨永悌二

脳循環代謝　27　(1)　190-190　2015/10
Publisher: 日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
【ブレインくんからの挑戦状!ドレーン管理正解はどっち?】スパイナルドレナージについて理解しよう

坂田洋之

Brain Nursing　31　(7)　656-659　2015/07
Publisher: (株)メディカ出版
ISSN： 0910-8459
緩徐進行性に発症し,癌性髄膜炎との鑑別を要したアテローム血栓塞栓性梗塞の1例

梅垣翔, 齋藤竜太, 赤松洋祐, 坂田洋之, 佐藤健一, 藤村幹, 園田順彦, 冨永悌二

Neurological Surgery　43　(4)　339-343　2015/04
Publisher: (株)医学書院
ISSN： 0301-2603

eISSN： 1882-1251
1型糖尿病に合併した成人・類もやもや病の1手術例

赤松洋祐, 藤村幹, 坂田洋之, 遠藤英徳, 板橋亮, 冨永悌二

Neurological Surgery　43　(3)　227-233　2015/03
Publisher: (株)医学書院
ISSN： 0301-2603

eISSN： 1882-1251

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32歳女。6歳時に1型糖尿病を発症しインスリン自己注射を行っていた。右眼前暗黒感で受診し、MRIで頭蓋内虚血性病変を指摘された。123I-IMP SPECTでは、左前頭葉・頭頂葉において左前頭葉の梗塞巣周囲に広がる安静時血流低下を認めた。左大脳半球に直接・間接血行再建術を施行した。周術期の血糖コントロールは持続皮下インスリン注入療法にボーラスインスリン療法を併用した。過灌流症候群の予防を目的として、術直後より予防的降圧とミノサイクリン塩酸塩投与を開始した。術翌日、7日目のSPECT上も明らかな過灌流はみられなかった。術後MRAでは良好なSTAの開通性を確認し、拡散強調像でも新たな虚血性病変はなく、術後2週間で神経学的欠損症状もなく自宅退院した。術後3ヵ月間、脳血管イベントはなく経過している。
perimedullary AVFとdural AVF合併の一例

伊藤明, 遠藤俊毅, 佐藤健一, 新妻邦泰, 坂田洋之, 冨永悌二

日本脊髄外科学会プログラム・抄録集　30th　2015
もやもや病疾患感受性遺伝子RNF213c.14484G>A変異マウスにおける経時的頭部MRA所見に関する検討

鹿毛淳史, 藤村幹, 新妻邦泰, 坂田洋之, 伊藤明, 前田美香, 呉繁夫, 冨永悌二

東北医学雑誌　127　(1)　2015

ISSN： 0040-8700
ステント支援下瘤内塞栓術後の患者に対する退院指導の重要性

伊藤亜沙美, 本郷磨依子, 太田祥代, 齋藤美奈子, 小野崎美樹, 松本康史, 佐藤健一, 坂田洋之

JNET: Journal of Neuroendovascular Therapy　8　(6)　449-449　2014/12
Publisher: (一社)日本脳神経血管内治療学会
ISSN： 1882-4072

eISSN： 2186-2494
M1 distalからM2閉塞に対するステント型血栓回収機器の当院での使用成績~血栓全体をretreval/active zoneで覆えない場合の経験より

重畠裕也, 板橋亮, 川田健太, 矢澤由加子, 坂田洋之, 佐藤健一, 松本康史, 古井英介

Journal of Neuroendovascular Therapy　8　(6)　322　2014/12/01

ISSN： 1882-4072
AVM塞栓術の適応と方法 OnyxとNBCAの使い分け AVM塞栓術の治療戦略 OnyxとNBCAの使い分け

松本康史, 佐藤健一, 坂田洋之, 遠藤英徳, 藤原悟, 高橋明, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　8　(6)　179-179　2014/12
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072

eISSN： 2186-2494
CEA術前後にSPECTは必須か?

井上敬, 藤村幹, 佐藤健一, 遠藤英徳, 新妻邦泰, 坂田洋之, 江面正幸, 上之原広司, 藤原悟, 冨永悌二

脳循環代謝　26　(1)　200-200　2014/11
Publisher: 日本脳循環代謝学会
ISSN： 0915-9401

eISSN： 2188-7519
もやもや病疾患感受性遺伝子RNF213 R4859K変異マウスにおける経時的頭部MRA所見に関する検討

鹿毛淳史, 藤村幹, 新妻邦泰, 坂田洋之, 伊藤明, 前田美香, 呉繁夫, 冨永悌二

脳循環代謝　26　(1)　180-180　2014/11
Publisher: 日本脳循環代謝学会
ISSN： 0915-9401
もやもや病疾患感受性遺伝子RNF213ノックアウトマウスの一過性局所脳虚血への反応性の検討

伊藤明, 藤村幹, 新妻邦泰, 坂田洋之, 鹿毛淳史, 呉繁夫, 冨永悌二

脳循環代謝　26　(1)　208-208　2014/11
Publisher: 日本脳循環代謝学会
ISSN： 0915-9401
Experimental Model of Lacunar Infarcts in Mice with Long-Lasting Functional Disabilities

Hiroki Uchida, Hiroyuki Sakata, Miki Fujimura, Kuniyasu Niizuma, Mari Dezawa, Teiji Tominaga

CEREBROVASCULAR DISEASES　38　9-9　2014/09

ISSN： 1015-9770

eISSN： 1421-9786
周術期管理に苦慮した動脈硬化を合併した成人類もやもや病の1例

坂田洋之, 藤村幹, 佐藤健一, 清水宏明, 冨永悌二

Neurological Surgery　42　(8)　737-743　2014/08
Publisher: (株)医学書院
ISSN： 0301-2603

eISSN： 1882-1251
血管内手術および直達手術で治療した幼児横静脈洞部硬膜動静脈瘻の1例

新妻邦泰, 坂田洋之, 小山新弥, 昆博之, 長南雅志, 佐々木達也, 西嶌美知春, 江面正幸, 冨永悌二

Neurological Surgery　40　(11)　1015-1020　2012/11
Publisher: (株)医学書院
ISSN： 0301-2603

eISSN： 1882-1251
Increased Survival of Transplanted Neural Stem Cells with Minocycline Pretreatment by Antioxidant Gene Expression after Ischemic Stroke in Rats

Hiroyuki Sakata, Kuniyasu Niizuma, Hideyuki Yoshioka, Gab Seok Kim, Masataka Katsu, Joo Eun Jung, Purnima Narasimhan, Nobuya Okami, Teiji Tominaga, Pak H. Chan

STROKE　42　(3)　E94-E94　2011/03

ISSN： 0039-2499
両側視床病変を呈した脳静脈洞血栓症の一例

三木康生, 西江信, 布村仁一, 馬場正之, 西村真実, 坂田洋之, 西嶌美知春, 緑川宏

青森県立中央病院医誌　54　(3)　105-106　2009/09
Publisher: 青森県立中央病院
ISSN： 0387-0138
破裂脳動脈瘤に対する慢性期クリッピング術を前提にした急性期意図的部分塞栓術

西村真実, 藤田智昭, 坂田洋之, 堀恵美子, 三野正樹, 西嶌美知春, 緑川宏

Neurological Surgery　37　(8)　757-763　2009/08
Publisher: (株)医学書院
ISSN： 0301-2603

eISSN： 1882-1251
笑い発作が改善した視床下部過誤腫の1手術例

藤田智昭, 西村真実, 坂田洋之, 古野優一, 三野正樹, 堀恵美子, 貝森光大, 白根礼造, 西嶌美知春

Neurological Surgery　37　(8)　781-785　2009/08
Publisher: (株)医学書院
ISSN： 0301-2603

eISSN： 1882-1251
脳動脈瘤術後の慢性硬膜下血腫についての検討

米澤慎悟, 藤田智昭, 西村真実, 坂田洋之, 小濱みさき, 三野正樹, 堀恵美子, 西嶌美知春

青森県立中央病院医誌　54　(2)　75-77　2009/06
Publisher: 青森県立中央病院
ISSN： 0387-0138
小児脳腫瘍の特性小児悪性脳腫瘍転移病巣の休眠状態

坂田洋之, 隈部俊宏, 金森政之, 斉藤竜太, 永松謙一, 山下洋二, 園田順彦, 田代学, 渡辺みか, 冨永悌二

Brain Tumor Pathology　26　(Suppl.)　50-50　2009/05
Publisher: 日本脳腫瘍病理学会
ISSN： 1433-7398

eISSN： 1861-387X
Chronic Subdural Hematoma and Remote Cerebellar Hemorrhage Developing after Unruptured Aneurysmal Surgery

NISHIMURA Shinjitsu, FUJITA Tomoaki, SAKATA Hiroyuki, HORI Emiko, MINO Masaki, NISHIJIMA Michiharu

Surgery for Cerebral Stroke　37　(5)　350-356　2009
Publisher: The Japanese Society on Surgery for Cerebral Stroke
DOI： 10.2335/scs.37.350 　 10.2176/nmc.oa.2014-0455_references_DOI_XzzgKPBA0SdkVvdwFpFiq50t1Df 　

ISSN： 0914-5508

eISSN： 1880-4683

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Postoperative chronic subdural hematoma (CSH) and remote cerebellar hemorrhage (RCH) is one of the important complications for treatment of unruptured intracranial aneurysm. The purpose of this study was to determine how to prevent CSH and RCH following the treatment of unruptured intracranial aneurysms. Between January 2000 and December 2007, 290 patients underwent clipping for unruptured intracranial aneurysms at our institution. We studied the patient's age and sex, location, size and multiplicity of aneurysm, the craniotomy site, the operative time required, operator and the procedure and the methods of anesthesia. We also reviewed the findings and outcomes of CSH and RCH. The incidence was 4.4% (males, 9.5%; females, 2.9%) and the mean age was 65 years with CSH. The incidence of RCH was 6.0% (males, 6.8%; females, 5.8%) and the mean age was 59.5 years. There was no statical significance in the occurrence of CSH or RCH in location, size and multiplicity of aneurysm or the operative time required. RCH occurred in 4.4% of cases using inhalation anesthesia, and 7.2% in total intravenous anesthesia, respectively. There was no evidence of associated morbidity in any of the cases. CSH occurred predominantly in male patients over 65 years old. The risk of RCH was intraoperative draining of large volumes of CSF, total intravenous anesthesia with mannitol use and postoperative drainage of larger amounts of fluid. The results showed the importance of careful operative procedure and the effectiveness of arachnoid plasty in preventing CSH and RCH.
抗血栓療法と慢性硬膜下血腫との関連性について

藤田智昭, 西村真実, 坂田洋之, 三野正樹, 堀恵美子, 西嶌美知春

青森県立中央病院医誌　53　(3)　129-131　2008/09
Publisher: 青森県立中央病院
ISSN： 0387-0138
高齢者での内頸動脈内膜剥離術施行例の検討

西野晶子, 鈴木一郎, 坂田洋之, 仁村太郎, 宇都宮昭裕, 鈴木晋介, 上之原広司, 桜井芳明

The Mt. Fuji Workshop on CVD　26　91-91　2008/07
Publisher: The Mt. Fuji Workshop on CVD事務局
ISSN： 0289-8438
両側視床病変を呈した脳静脈洞血栓症の1例

三木康生, 坂田洋之, 西江信, 布村仁一, 西嶌美知春, 馬場正之, 東海林幹夫

臨床神経学　48　(7)　515-515　2008/07
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
解離性脳動脈瘤の治療成績と長期予後についての検討

西嶌美知春, 堀恵美子, 三野正樹, 藤田智昭, 坂田洋之, 上山浩永, 西村真実

青森県立中央病院医誌　53　(2)　95-97　2008/06
Publisher: 青森県立中央病院
ISSN： 0387-0138
硬膜動静脈瘻(dural AVF)の成因に関する臨床病理学的検討

西村真実, 西嶌美知春, 坂田洋之, 藤田智昭, 三野正樹, 堀恵美子, 貝森光大

青森県立中央病院医誌　53　(2)　97-97　2008/06
Publisher: 青森県立中央病院
ISSN： 0387-0138
抗血小板・抗凝固療法中の慢性硬膜下血腫症例についての臨床的研究

藤田智昭, 西村真実, 坂田洋之, 三野正樹, 堀恵美子, 上山浩永, 西嶌美知春

青森県立中央病院医誌　53　(2)　98-100　2008/06
Publisher: 青森県立中央病院
ISSN： 0387-0138
慢性硬膜下血腫に対する穿頭ドレナージ術後の血腫外膜外血腫の一例慢性硬膜下血腫の出血源と中硬膜動脈塞栓術の有用性

三野正樹, 西村真実, 藤田智昭, 堀恵美子, 坂田洋之, 緑川宏, 西嶌美知春

日本神経外傷学会プログラム・抄録集　31回　86-86　2008/04
Publisher: (一社)日本脳神経外傷学会
部分コイル塞栓術後クリッピングを行った破裂脳動脈瘤の1症例

西村雅之, 堀恵美子, 西村真実, 藤田智昭, 三野正樹, 坂田洋之, 緑川宏, 西嶌美知春

青森県立中央病院医誌　53　(1)　24-27　2008/03
Publisher: 青森県立中央病院
ISSN： 0387-0138
evidence-based medicineの功罪経過観察中に破裂した未破裂脳動脈瘤症例についての検討 Evidence-Based Medicineの功罪

三野正樹, 西村真実, 堀恵美子, 藤田智昭, 坂田洋之, 西嶌美知春

脳卒中　30　(2)　206-206　2008/03
Publisher: (一社)日本脳卒中学会
ISSN： 0912-0726

eISSN： 1883-1923
脳卒中急性期における画像電送装置を用いた遠隔医療

藤田智昭, 西村真実, 坂田洋之, 三野正樹, 堀恵美子, 西嶌美知春

脳卒中　30　(2)　254-254　2008/03
Publisher: (一社)日本脳卒中学会
ISSN： 0912-0726

eISSN： 1883-1923
大脳皮質下出血の臨床的検討 occult AVMの存在

坂田洋之, 西村真実, 藤田智昭, 三野正樹, 堀恵美子, 西嶌美知春

脳卒中　30　(2)　338-338　2008/03
Publisher: (一社)日本脳卒中学会
ISSN： 0912-0726

eISSN： 1883-1923
硬膜動静脈瘻の成因に関する臨床的検討 denovo症例および多発症例を中心に

西村真実, 坂田洋之, 藤田智昭, 三野正樹, 堀恵美子, 西嶌美知春

脳卒中　30　(2)　366-366　2008/03
Publisher: (一社)日本脳卒中学会
ISSN： 0912-0726

eISSN： 1883-1923
頭蓋内海綿状血管腫の治療成績についての検討

三野正樹, 西村真実, 堀恵美子, 藤田智昭, 坂田洋之, 西嶌美知春

脳卒中　30　(2)　366-366　2008/03
Publisher: (一社)日本脳卒中学会
ISSN： 0912-0726

eISSN： 1883-1923
解離性脳動脈瘤の治療法選択と成績

堀恵美子, 西村真実, 三野正樹, 藤田智昭, 坂田洋之, 西嶌美知春

脳卒中　30　(2)　393-393　2008/03
Publisher: (一社)日本脳卒中学会
ISSN： 0912-0726

eISSN： 1883-1923
破裂脳動脈瘤治療の現状 clipping vs coil 破裂脳動脈瘤治療の現状 neck clippingとcoilingの役割

西村真実, 藤田智昭, 坂田洋之, 堀恵美子, 三野正樹, 西嶌美知春, 緑川宏

日本脳神経外科救急学会プログラム・抄録集　13回　89-89　2008/01
Publisher: (NPO)日本脳神経外科救急学会
Subarachnoid hemorrhage during conservative management of unruptured intracranial aneurysms

Mino Masaki, Nishimura Shinjitsu, Hori Emiko, Fujita Tomoaki, Sakata Hiroyuki, Nishijima Michiharu

Japanese Journal of Stroke　30　(6)　925-930　2008
Publisher: The Japan Stroke Society
DOI： 10.3995/jstroke.30.925 　

ISSN： 0912-0726

eISSN： 1883-1923

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Purpose We aimed to assess the natural history of unruptured intracranial aneurysms and considered the risk factors of their rupture. Objectives and Methods We assessed 192 unruptured aneurysms in 162 patients that were managed conservatively. Concerning the cases that presented subarachnoid hemorrhage during observation, we assessed the risk factors of rupture, including location, size, shape, and enlargement of aneurysms. Results Among 192 aneurysms, 36% were located at internal carotid artery, 32% at middle cerebral artery, 11% at vertebro-basilar artery, and 11% at anterior communicating artery. During observation, 9 aneurysms ruptured. Three aneurysms were located at basilar artery, 3 at middle cerebral artery, 1 at anterior communicating artery, 1 at distal anterior cerebral artery, and 1 at posterior cerebral artery. Among 9 cases, 5 had multiple aneurysms and 3 had previous history of subarachnoid hemorrhage. Four aneurysms were larger than 10 mm, but 4 were smaller than 5 mm. Enlargement of aneurysms were found in 4 cases. All cases had more than two risk factors of rupture. Conclusions We thought that even for patients of high age with unruptured aneurysms, if he has more than two risk factors of rupture, we have to consider surgical treatment positively.
くも膜下出血と血管閉塞が同時に見られた椎骨動脈解離の1症例—第30回東北脳血管障害研究会

藤田智昭, 西村真実, 坂田洋之

東北脳血管障害研究会学術集会記録集 : cerebrovascular disease Tohoku / [東北脳血管障害研究会] [編]　30　35-38　2007/12/01
Publisher: 仙台 : アベンティスファーマ仙台オフィス
ISSN： 1880-9278
80歳以上のくも膜下出血症例の検討

鈴木一郎, 西野晶子, 齋藤竜太, 坂田洋之, 宇都宮昭裕, 仁村太郎, 鈴木晋介, 上之原広司, 櫻井芳明

日本脳神経外科学会総会CD-ROM抄録集　66回　2K-14　2007/10
Publisher: (一社)日本脳神経外科学会
ISSN： 1347-9040
重症くも膜下出血症例の治療成績の検討

西野晶子, 鈴木一郎, 齋藤竜太, 坂田洋之, 宇都宮昭裕, 仁村太郎, 鈴木晋介, 上之原広司, 桜井芳明

日本脳神経外科学会総会CD-ROM抄録集　66回　3J-1　2007/10
Publisher: (一社)日本脳神経外科学会
ISSN： 1347-9040
36 幼児期に発症した頭蓋頚椎移行部のNeuroenteric cystの1手術例(北日本脳神経外科連合会第30回学術集会)

坂田洋之, 藤村幹, 岩崎真樹, 冨永悌二

新潟医学会雑誌　121　(4)　224-225　2007/04
Publisher: 新潟大学
ISSN： 0029-0440
小児脳腫瘍の病理稀な組織型を呈したmedulloblastomaの2例

坂田洋之, 金森政之, 岩崎真樹, 渡辺みか, 隈部俊宏, 冨永悌二

Brain Tumor Pathology　23　(Suppl.)　87-87　2006/06
Publisher: 日本脳腫瘍病理学会
ISSN： 1433-7398

eISSN： 1861-387X

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Books and Other Publications 7

ブレインナーシング 2019年11月号(第35巻11号)特集:【わかった! につながるコアスタディ】脳卒中患者さんを看るためにだいじな動脈10

坂田洋之

メディカ出版　2019/10/21

ISBN: 4840466203
症例から学ぶ脳血管内治療広南流 30の戦略2

坂田洋之

中外医学社　2018/11
症例から学ぶ脳血管内治療広南流 30の戦略1

坂田洋之

中外医学社　2018/11
Brain Nursing

Hiroyuki Sakata

Medica Shuppan　2015/07
Practical Neurosurgery 5

Hiroyuki Sakata

Bunkodo　2015/04
Practical Neurosurgery 4

Hiroyuki Sakata

Bunkodo　2014/10
Immunological Mechanisms and Therapies in Brain Injuries and Stroke.

Narasimhan P, SAKATA H, Jung JE, Nishi T, Wakai T, Maier CM, Chan PH

Springer　2014/01

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Presentations 3

高齢者に対する機械的血栓回収療法の現状 Invited

坂田洋之, 江面正幸, 石田朋久, 遠藤英徳, 井上敬, 上之原広司, 冨永悌二

第34回日本老年脳神経外科学会
第64回日本脳循環代謝学会学術集会 Invited

坂田洋之, 江面正幸, 石田朋久, 斉藤敦志, 遠藤英徳, 上之原広司, 冨永悌二

第64回日本脳循環代謝学会学術集会
術前Dual energy CT画像による血栓性状診断: 血栓回収療法の新たな治療戦略の提唱

坂田洋之, 江面正幸, 石田朋久, 斉藤敦志, 遠藤英徳, 上之原広司, 冨永悌二

第37回日本脳神経血管内治療学会学術総会

Research Projects 11

Mechanical thrombectomy targeting immunothrombosis

Offer Organization: The Japanese Society for Neuroendovacular Therapy

2025/04 - 2027/03
Elucidation of the pathogenesis of moyamoya disease through Endothelial-Smooth Muscle Interaction and RNF213

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (A)

Institution: Tohoku University

2023/04/01 - 2026/03/31
急性期脳梗塞における免疫血栓を標的とした新規治療法の開発

坂田洋之

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(C)

Category: 基盤研究(C)

Institution: 東北大学

2023/04 - 2026/03
シロスタゾールを用いたもやもや病における内因性幹細胞賦活と血管新生促進療法の開発

藤村幹, 冨永悌二, 新妻邦泰, 麦倉俊司, 坂田洋之

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

2020/04/01 - 2023/03/31

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もやもや病は異常血管網発達ならびに代償的な側副血行路を含めた血管新生能を有する原因不明の疾患である。小児や若年成人に好発し、浅側頭動脈・中大脳動脈吻合術（直接血行再建術）や側頭筋を用いた間接血行再建術を含めた外科治療の有効性が確立しているが、重症例に対する治療は未確立である。間接術は脳損傷を伴う重症例にも安全に行うことが可能であるが、間接術単独の場合は血管新生不良例が見られる点が問題である。血管新生能を高める試みがなされているがその効果は限定的であるのが現状である。今回、内因性多能性幹細胞とその活性化に期待が持てる薬剤に着目し、間接術からの血管新生の機序を解明し、その効果を促進する手法を開発することによりもやもや病の治療成績の向上が期待できると着想した。本研究の目的は、もやもや病患者クモ膜における内因性多能性幹細胞の発現と血行再建術後の血管新生の関連を明らかにし、「もやもや病に対するシロスタゾールを用いた内因性多能性幹細胞の賦活と血行再建術効果促進」の概念実証し、臨床レベルでもやもや病手術例に対するシロスタゾールを用いた内因性多能性幹細胞の賦活による血行再建術効果療法を確立することである。２年度目は、血行再建術を行ったもやもや病患者に由来する検体を用いて、患者クモ膜組織における内因性多能性幹細胞を免疫組織学的に検討した。18例の患者より得られたクモ膜について、多能性幹細胞の複数の指標について免疫組織染色を行ったところ多くの検体において多能性幹細胞マーカー陽性所見を認めた。また術後MRAを行い血管新生の程度と術前脳虚血、RNF213遺伝子異常との関連を検証し有意な結果を得た。もやもや病患者クモ膜において内因性多能性幹細胞が存在すること、RNF213遺伝子変異により血管新生が増幅されることが示唆された。
Development of Muse cell therapy for dementia

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2020/04/01 - 2023/03/31
Prediction of ischemic stroke due to carotid artery stenosis based on efferocytosis

Sakata Hiroyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists

Category: Grant-in-Aid for Early-Career Scientists

Institution: Tohoku University

2019/04 - 2022/03

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We collected the blood samples from 37 patients with symptomatic or asymptomatic carotid artery stenosis. We analyzed the expression of efferocytosis-related molecules, including Mfge8,CD47, GAS6, IL-10, IL-13, MERTK, and MPO. Significanlt relations were observed between symptomatic lesions and efferocytosis-related molecules.
Neo-angiogenesis induction by pluripotent stem cell Muse as a new therapeutic strategy for severer form of moyamoya disease

Miki Fujimura

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2017/04/01 - 2020/03/31

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In the laboratory research, we established a reproducible chronic hypoperfusion model using mice and rat, and found significant neo-angiogenesis and the migration of immune cells to the brain surface after indirect pial synangiosis. Using moyamoya disease patients’ sample, we found increased serum levels of sCD163 (M2 macrophage-associated factor) and CXCL5, suggesting the contribution of intrinsic immune reaction in its pathophysiology （Fujimura et al. Brain Res 2018）. Finally, we found marked expression of endogenous pluripotent stem cells in the arachnoid membrane of moyamoya disease patients, indicating the possible role of endogenous stem cells in the intrinsic angiogenesis in moyamoya disease (Fujimura et al. submitted）.
Platform for regenerative therapy of central nervous system using Muse cells

TOMINAGA TEIJI

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (A)

Institution: Tohoku University

2017/04/01 - 2020/03/31

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Cerebral infarction accounts for ~60% of the total stroke and the number of patients is increasing. Even with the current sophisticated treatments including thrombolysis and thrombectomy, more than half patients get disabled. Therefore, it is imperative to develop a new treatment to enhance recovery and restore the lost neurological functions. Multilineage-differentiating stress-enduring (Muse) cells are endogenous nontumorigenic stem cells with pluripotency and minimum safety concerns. Muse cells recognize the injured site, home preferentially into the tissue and spontaneously differentiate into tissue-compatible cells to replace the lost cells, and repair the tissue, delivering functional and structural regeneration. The purpose of this study is to develop Muse cell therapy for central nervous system disorders. If Muse cell treatment was successfully developed, the social and economic impact is unimaginable.
New concept of local chemo- and cell-therapy for spinal cord injury using convection-enhanced drug delivery

Sugiyama Shinichiro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2015/04/01 - 2018/03/31

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Spinal cord injury has dismal prognosis even in this modern era. Convection-enhanced delivery (CED) is a method for distributing small and large molecules locally in the interstitial space of the spinal cord. Delivering these molecules to the spinal cord is otherwise difficult due to the blood spinal cord barrier. This study revealed that regional infusion of drugs into the spinal cord via CED is a promising strategy for treating spinal cord injury. In addition, we investigated the safety and efficacy of stem cell transplantation (multilineage-differentiating stress enduring cell (Muse cell) transplantation) in spinal cord injury.
多能性幹細胞(Muse細胞)による脳深部白質梗塞に対する白質再建 Competitive

坂田洋之

Offer Organization: 科学研究費助成事業

System: 若手研究A

2015/04 - 2018/03
Establishment of the stem cell transplantation therapy by MUSE for moyamoya disease

Miki Fujimura

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2014/04/01 - 2017/03/31

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The objective of this study was to establish stem cell transplantation therapy using pluripotent MUSE cells for the patients with moyamoya disease. Mice and rats were subjected to chronic cerebral ischemia and then underwent indirect pial synangiosis, in a consistent situation of indirect bypass for moyamoya disease. Two-staged carotid artery occlusion reproducibly provided chronic hypoperfusion and the development of pial synangiosis by our methods. To obtain more similar condition to moyamoya disease, we alternatively generated genetically-engineered mice of RNF213, a susceptibility gene for moyamoya disease. Spontaneous development of moyamoya disease was not evident in these mice, while RNF213-deficient mice demonstrated decreased ratio of regulatory T cells after immunologic adjuvant administration. Regarding MUSE cell preparation, using MUSE cells were successfully sorted by anti- SSEA-3/CD105 antibodies from cultured mesenchymal stromal cells.

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