Details of the Researcher

PHOTO

Kazuhiro Imoto
Section
Tohoku University Hospital
Job title
Assistant Professor
Degree

  • DDS, Ph.D (Tohoku University)

e-Rad No.
90972828

Research History 6

  • 2025/04 - Present
    東北大学大学院 歯学研究科 顎顔面口腔再建外科学分野　助教

  • 2025/01 - 2025/03
    東北大学大学院 歯学研究科 顎顔面口腔再建外科学分野　診療助教

  • 2022/06 - 2024/12
    東北大学病院 歯科顎口腔外科　医員

  • 2021/04 - 2022/05
    石巻赤十字病院 歯科口腔外科

  • 2017/04 - 2021/03
    東北大学大学院歯学研究科 顎顔面・口腔外科学分野

  • 2010/04 - 2016/03
    東北大学歯学部

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Education 2

  • 東北大学大学院 歯学研究科

    2017/04 - 2021/03

  • 東北大学歯学部

    2010/04 - 2016/03

Papers 11

  1. 下顎後退症患者に対する下顎前方移動後の下顎頭の3次元的形態評価

    岩前 有香, 武田 裕利, 菅井 優生, 矢崎 麻衣, 奥山 喬介, 井本 和宏, 齋藤 志都, 江副 祐史, 野上 晋之介, 山内 健介

    日本口腔科学会雑誌　74　(2)　150-150　2025/07

    Publisher: (NPO)日本口腔科学会

    ISSN： 0029-0297

    eISSN： 2185-0461

  2. インプラント周囲に発症した薬剤関連顎骨壊死の4症例

    岩前 有香, 武田 裕利, 服部 雄介, 五十嵐 彩乃, 冨塚 賢弥, 井本 和宏, 江副 祐史, 森島 浩允, 野上 晋之介, 山内 健介

    顎顔面補綴　48　(1)　66-66　2025/06

    Publisher: (一社)日本顎顔面補綴学会

    ISSN： 0389-4045

    eISSN： 2435-0389

  3. Osteonecrosis of the jaw in a patient treated with alendronate and then denosumab: A case of dramatic amelioration by minocycline and then etidronate

    Takefumi Oizumi, Kazuhiro Imoto, Kanan Bando, Yukinori Tanaka, Hiromi Funayama, Kensuke Yamauchi, Hiroyuki Kumamoto, Tetsu Takahashi, Yasuo Endo

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology　37　(2)　348-355　2025/03

    Publisher: Elsevier BV

    DOI： 10.1016/j.ajoms.2024.07.012 　

    ISSN： 2212-5558

  4. Relationship of preoperative serum data with MRONJ patient postoperative course – Retrospective study

    Yuri Takeda, Yushi Ezoe, Yuka Iwamae, Tai Kimura, Kenya Tomitsuka, Shinki Koyama, Kazuhiro Imoto, Hiromitsu Morishima, Shinnosuke Nogami, Kensuke Yamauchi

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology　2025

    DOI： 10.1016/j.ajoms.2025.02.006 　

    ISSN： 2212-5558

  5. Periosteal expansion osteogenesis using a tubular dynamic frame device: An experimental study in rats. International-journal

    Karen Hoshi, Kazuhiro Imoto, Yuta Yanagisawa, Shinnosuke Nogami, Hidero Unuma, Kensuke Yamauchi

    Journal of biomedical materials research. Part B, Applied biomaterials　112　(9)　e35471　2024/09

    DOI： 10.1002/jbm.b.35471 　

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    Periosteal expansion osteogenesis (PEO) is a technique for augmenting bone by creating a gradual separation between the bone and periosteum. This study assessed PEO-induced bone formation around the femurs of rats using a dynamic frame device (DFD), consisting of a shape memory membrane made of polyethylene terephthalate (PET) formed into a tubular shape. The DFDs, consisting of a PET membrane coated with hydroxyapatite (HA)/gelatin on the bone-contact surface, were inserted between the periosteum and bone of the femurs of rats. In the experimental group, DFDs were suture-fixed to the femur with 4-0 Vicryl Rapid; in the control group, 4-0 silk thread was used for fixation. Five rats per group were euthanized at intervals of 3, 5, and 8 weeks postoperatively. Bone formation was evaluated via micro-CT imaging, histomorphometry, and histological analysis. Morphological analysis revealed new bone between the femur and the periosteum, expanded by the DFD, in all groups. The mean values of new bone were 0.30 mm2 proximally, 0.18 mm2 centrally, and 0.82 mm2 distally in the control group, compared to 1.05 mm2 proximally, 0.27 mm2 centrally, and 0.84 mm2 distally in the experimental group. A significant difference in new bone was observed in the proximal region of the experimental group. Histological examination showed that a single layer of newly formed neoplastic bone was noted on the cortical bone surface across all sites. The proximal portion displayed a bone marrow cavity at the center, encircled by a thick bone cortex with a layered structure. New bone formation was notable between existing cortical bone and the periosteum, particularly at both ends of the DFD. The use of PET in PEO was a viable option for achieving ideal bone morphology.

  6. Static and dynamic guided bone regeneration using a shape-memory polyethylene terephthalate membrane: An experimental study in rabbit mandible. International-journal

    Kazuhiro Imoto, Karen Hoshi, Kenji Odashima, Shinnosuke Nogami, Hidero Unuma, Kensuke Yamauchi

    Clinical implant dentistry and related research　2024/05/28

    DOI： 10.1111/cid.13337 　

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    BACKGROUND: Periosteal expansion (PEO) results in the formation of new bone in the space created between existing bone by expanding the periosteum. PEO has already been performed on rabbit parietal bone and effective new bone formation has been demonstrated. In this study, the utility of a polyethylene terephthalate (PET) membrane as an activator was evaluated in the more complex morphology of the mandible. METHODS: A PET membrane coated with hydroxyapatite (HA)/gelatine was placed in the rabbit mandibular bone at lower margin of mandibular molar region underneath periosteum, and screw-fixed. In the experimental group, the membrane was bent and screw-fixed along the lateral surface of the bone, with removal of the outer screw after 7 days followed by activation of the membrane. The experimental group was divided into two subgroups: with and without a waiting period for activation. Three animals were euthanized at 3 weeks and another three at 5 weeks postoperatively. Bone formation was assessed using micro-CT as well as histomorphometric and histological methods. RESULTS: No PET membrane-related complications were observed. The area of newly formed bone and the percentage of new bone in the space created by the stretched periosteum did not significantly differ between the control and experimental groups. However, in the experimental group a greater volume was present after 5 weeks than after 3 weeks. Histologically, bone formation occurred close to the site of cortical bone perforation, with many sinusoidal vessels extending through the perforations in the new bone into the overlying fibrous tissue. Inflammatory cells were not seen in the bone.

  7. 上顎洞内に生じたセメント質骨性異形成症の1例

    柳沢 佑太, 橋元 亘, 野上 晋之助, 井本 和宏, 山内 健介, 熊本 裕行, 高橋 哲

    東北大学歯学雑誌　41/42　(2/1)　27-31　2023/06

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

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    症例は55歳男性で、歯科治療目的に紹介元歯科医院を受診し、パノラマX線写真で左側上顎洞内に不透過性病変を指摘され、加療依頼で当科紹介初診となった。画像所見より左側上顎骨腫瘍と診断し、全身麻酔下に顎骨腫瘍摘出術を施行した。病変は上顎洞前壁および上顎洞底に連続しており、上顎洞前壁に沿って分離し一塊として摘出した。創部を洗浄後、骨窓を復位し吸収性縫合糸で固定した後、粘膜弁を閉鎖縫合し手術を終了した。術後は疼痛や鼻症状などの自覚症状を認めず、術後感染もなく経過し、術後1年時点で病変の再発は認めなかった。病理組織学的所見では、病変は既存骨と連続してセメント質ないし梁状の骨様硬組織を形成しており、限局性セメント質骨性異形成症と診断した。

  8. A case of tenosynovial giant cell tumor secondary to synovial chondromatosis in the temporomandibular joint

    Hiromitsu Morishima, Shinnosuke Nogami, Ayano Igarashi, Kazuhiro Imoto, Shizu Saito, Masatoshi Chiba, Hiroyuki Kumamoto, Tetsu Takahashi, Kensuke Yamauchi

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology　2023/03

    Publisher: Elsevier BV

    DOI： 10.1016/j.ajoms.2023.03.009 　

    ISSN： 2212-5558

  9. A collagen membrane for periosteal expansion osteogenesis using a timed-release system in rabbit calvaria. International-journal

    Kensuke Yamauchi, Kazuhiro Imoto, Kenji Odajima, Hiromitsu Morishima, Yoshinaka Shimizu, Shinnosuke Nogami, Tetsu Takahashi

    International journal of implant dentistry　8　(1)　9-9　2022/03/04

    DOI： 10.1186/s40729-022-00407-5 　

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    BACKGROUND: The purpose of this study was to evaluate the effects of resorbable membranes, combined with a shape memory alloy (SMA) mesh device, on bone formation using a timed-release system for periosteal expansion osteogenesis (TIME-PEO). MATERIALS AND METHODS: Twelve Japanese white rabbits were used in this study. An SMA device was inserted under the forehead periosteum, pushed and bent for attachment to the bone surface, and then fixed using resorbable thread. The rabbits were divided into four groups: C1 (5 weeks postoperatively without membrane), C2 (8 weeks postoperatively without membrane), E1 (5 weeks postoperatively with membrane), and E2 (8 weeks postoperatively with membrane). The rabbits were killed 5 or 8 weeks after the operation and the newly formed bone was assessed histologically and radiographically. RESULTS: SMA devices, concealed under soft tissue until the time of euthanasia, did not cause active inflammation. The mean activation height, from the original bone surface to the midpoint of the mesh, was 3.1 ± 0.6 mm. Newly formed bone was observed, and most of the subperiosteal space underneath the device was occupied by fibrous tissue. Immature bone was present at the outer surface of the original skull bone in all groups. On histomorphometric analysis, there was no significant difference in the volume of the new bone between C1 and E1 (p = 0.885), and C2 and E2 (p = 0.545). CONCLUSIONS: PEO using an SMA mesh device, which is based on guided bone regeneration (in atrophic alveolar bone), shows promise as an alternative for bone augmentation, irrespective of whether a resorbable membrane is used.

  10. Condylar Resorption Following Compressive Mechanical Stress in Rabbit Model - Association of Matrix Metalloproteinases. International-journal

    Shinnosuke Nogami, Yoshihiro Kataoka, Kensuke Yamauchi, Yuta Yanagisawa, Kazuhiro Imoto, Akira Kumasaka, Kuniyuki Izumita, Tomonari Kajita, Masahiro Iikubo, Hiroyuki Kumamoto, Tetsu Takahashi

    In vivo (Athens, Greece)　36　(5)　2126-2133　2022

    DOI： 10.21873/invivo.12938 　

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    BACKGROUND/AIM: Idiopathic condylar resorption (ICR) is a morphological change of the condylar head that occurs following orthodontic treatment or orthognathic surgery. This complication is serious, as it can cause relapse after mandible treatment. The aim of this experimental study was to evaluate the mechanism of influence of condylar resorption on compressive mechanical stress in temporomandibular joint following a change in occlusal position by mandible advancement. MATERIALS AND METHODS: An osteotomy procedure at the midline of mandible was performed in 15 rabbits, with the left side moved forward by 3.5 mm. Advancement of the left side of the mandible resulted in compressive mechanical stress on condylar head on the left side. Samples were subjected to micro-computed tomography, histological staining and immunohistochemistry. RESULTS: The area and depth of anterior condylar resorption at two weeks were significantly different as compared to those at one week (p<0.05). TRAP staining confirmed the significantly largest number of TRAP-positive cells after two weeks (p=0.02), compared to one week. MMP-3 and MMP-13 immunostaining of the anterior condylar head at two weeks revealed high levels of both proteins from the surface to the deep layer of cartilage. CONCLUSION: Compressive mechanical stress following mandible advancement results in load on the anterior surface of the condylar head, which leads to bone resorption there, and induces MMP-3 and MMP-13 related to degradation of condylar head cartilage.

  11. Periosteal expansion osteogenesis using an innovative, shape-memory polyethylene terephthalate membrane: An experimental study in rabbits. International-journal

    Kazuhiro Imoto, Kensuke Yamauchi, Kenji Odashima, Shinnosuke Nogami, Yoshinaka Shimizu, Peter Kessler, Bernd Lethaus, Hidero Unuma, Tetsu Takahashi

    Journal of biomedical materials research. Part B, Applied biomaterials　109　(9)　1327-1333　2021/09

    DOI： 10.1002/jbm.b.34793 　

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    Periosteal expansion osteogenesis (PEO) results in the formation of new bone in the gap between periosteum and original bone. The purpose of this study is to evaluate the use of a polyethylene terephthalate (PET) membrane as an activation device. A dome-shaped PET membrane coated with hydroxyapatite/gelatin on the inner side was inserted between the elevated periosteum and bone at the rabbit calvaria. In the experimental group, the membrane was pushed, bent, and attached to the bone surface and fixed with a titanium screw. In control group, the membrane was only inserted and fixed with titanium screw at original shape under the periosteum. After 7 days, the screw was removed and the mesh was activated in the experimental group. Three animals per group with or without setting a latency period for activation were sacrificed at 3 and 5 weeks after surgery. Bone formation was evaluated via micro-computed tomography and determined by histomorphometric methods and histological evaluation. No PET membrane-associated complications were observed during this study. The quantitative data by the area and the occupation of newly formed bone indicated that the experimental group had a higher volume of new bone than the control group at 3 weeks after surgery. Histologically, bone formation progressed to areas adjacent to the cortical perforations; many sinusoidal vessels ran from the perforations to overlying fibrous tissue via the new bone. No bone or obvious inflammatory cells were observed over the membrane. The PET membrane has biocompatible device for PEO that induces a natural osteogenic response at the gap between the original bone and periosteum.

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Misc. 19

  1. ラット下顎骨モデルによる骨造成法Shell techniqueでの骨間隙材料による骨形成過程の実験的検証

    権 寧こう, 森島 浩允, 柳沢 佑太, 井本 和宏, 野上 晋之介, 山内 健介

    日本口腔インプラント学会誌　37　(特別号)　O-89　2024/11

    Publisher: (公社)日本口腔インプラント学会

    ISSN： 0914-6695

    eISSN： 2187-9117

  2. インプラント周囲に発症した薬剤関連顎骨壊死の4症例

    岩前 有香, 武田 裕利, 服部 雄介, 五十嵐 彩乃, 冨塚 賢弥, 井本 和宏, 江副 祐史, 森島 浩允, 野上 晋之介, 山内 健介

    Japanese Journal of Maxillo Facial Implants　23　(3)　177-177　2024/11

    Publisher: (公社)日本顎顔面インプラント学会

    ISSN： 1347-894X

    eISSN： 2433-5509

  3. ナビゲーションシステムを用いた薬剤関連顎骨壊死の外科的治療の1例

    郷家 隆平, 武田 裕利, 岩前 有香, 冨塚 賢弥, 高山 慎騎, 井本 和宏, 森島 浩允, 江副 祐史, 野上 晋之介, 山内 健介

    日本口腔科学会雑誌　73　(3)　277-277　2024/09

    Publisher: (NPO)日本口腔科学会

    ISSN： 0029-0297

    eISSN： 2185-0461

  4. 下顎後退症に対して下顎骨形成術と同時に両側関節円板整位術を施行した1例

    齊藤 志都, 矢崎 麻衣, 奥山 喬介, 井本 和宏, 鈴木 飛佳理, 武田 裕利, 纐纈 衆, 野上 晋之介, 山内 健介

    日本顎変形症学会雑誌　34　(2)　112-112　2024/05

    Publisher: (NPO)日本顎変形症学会

    ISSN： 0916-7048

    eISSN： 1884-5045

  5. ナビゲーションシステムを用いた薬剤関連顎骨壊死の外科的治療の1症例

    郷家隆平, 武田裕利, 岩前有香, 冨塚賢弥, 高山慎騎, 井本和宏, 森島浩允, 江副祐史, 野上晋之介, 山内健介

    日本口腔科学会雑誌(Web)　73　(3)　2024

    ISSN： 2185-0461

  6. 形状記憶樹脂メンブレンを用いたラット大腿骨周囲の骨造成評価

    星 香蓮, 柳沢 佑太, 井本 和宏, 森島 浩允, 野上 晋之介, 山内 健介

    日本口腔インプラント学会誌　36　(特別号)　O-3　2023/09

    Publisher: (公社)日本口腔インプラント学会

    ISSN： 0914-6695

    eISSN： 2187-9117

  7. Le Fort I型骨切り術の上顎後方移動における翼突上顎縫合部の形態評価

    野上 晋之介, 武田 裕利, 齊藤 志都, 鈴木 飛佳理, 井本 和宏, 矢崎 麻衣, 黒田 佳奈子, 山内 健介

    日本顎変形症学会雑誌　33　(2)　142-142　2023/05

    Publisher: (NPO)日本顎変形症学会

    ISSN： 0916-7048

    eISSN： 1884-5045

  8. 当科での両側下顎枝矢状分割術における術中出血量に関する臨床的検討

    井本 和宏, 野上 晋之介, 矢崎 麻衣, 齊藤 志都, 鈴木 飛佳理, 武田 裕利, 山内 健介

    日本顎変形症学会雑誌　33　(2)　201-201　2023/05

    Publisher: (NPO)日本顎変形症学会

    ISSN： 0916-7048

    eISSN： 1884-5045

  9. 顎関節の滑膜性軟骨腫症に合併した腱滑膜巨細胞腫の1例

    五十嵐 彩乃, 野上 晋之介, 森島 浩允, 井本 和宏, 大竹 義雄, 纐纈 衆, 千葉 雅俊, 山内 健介, 熊本 裕行, 高橋 哲

    日本顎関節学会雑誌　34　(Suppl.)　143-143　2022/07

    Publisher: (一社)日本顎関節学会

    ISSN： 0915-3004

    eISSN： 1884-4308

  10. A case of tenosynovial giant cell tumor associated with synovial chondromatosis in the temporomandibular joint

    五十嵐彩乃, 野上晋之介, 森島浩允, 井本和宏, 大竹義雄, 纐纈衆, 千葉雅俊, 山内健介, 熊本裕行, 高橋哲, 高橋哲

    日本顎関節学会雑誌(Web)　34　2022

    ISSN： 1884-4308

  11. 当科における骨代謝調節薬投与患者に対する外科処置の臨床的検討

    高山 慎騎, 永井 宏和, 佐藤 舜, 井本 和宏, 森島 浩允, 武田 裕利, 江副 祐史, 高橋 哲

    日本口腔科学会雑誌　70　(2)　152-152　2021/07

    Publisher: (NPO)日本口腔科学会

    ISSN： 0029-0297

    eISSN： 2185-0461

  12. 腓骨再建後のインプラント治療において歯槽骨造成用チタンメッシュとテンティングスクリューを併用した骨造成法の臨床的検討

    井本 和宏, 山内 健介, 森島 浩允, 武田 裕利, 片岡 良浩, 高橋 哲

    Japanese Journal of Maxillo Facial Implants　19　(3)　178-178　2020/11

    Publisher: (公社)日本顎顔面インプラント学会

    ISSN： 1347-894X

    eISSN： 2433-5509

  13. 未治療の骨粗鬆症にてインプラント一次手術時に下顎骨内にインプラント体が迷入した一例

    森島 浩允, 井本 和宏, 斎藤 政二, 山内 健介, 高橋 哲

    Japanese Journal of Maxillo Facial Implants　19　(3)　186-186　2020/11

    Publisher: (公社)日本顎顔面インプラント学会

    ISSN： 1347-894X

    eISSN： 2433-5509

  14. 肩甲骨による下顎再建後にPCBMとTIME法を用いて広範囲顎骨支持型装置を応用した一例

    森島 浩允, 片岡 良浩, 井本 和宏, 武田 裕利, 山内 健介, 高橋 哲

    Japanese Journal of Maxillo Facial Implants　18　(3)　167-167　2019/11

    Publisher: (公社)日本顎顔面インプラント学会

    ISSN： 1347-894X

    eISSN： 2433-5509

  15. 骨膜伸展骨形成法での吸収性メンブレンの有用性に関する実験的研究

    山内 健介, 井本 和宏, 小田島 健二, 片岡 良浩, 野上 晋之介, 高橋 哲

    日本口腔インプラント学会誌　32　(特別号)　313-313　2019/09

    Publisher: (公社)日本口腔インプラント学会

    ISSN： 0914-6695

    eISSN： 2187-9117

  16. インプラント専門外来における下顎枝から採取した自家骨移植の臨床的検討

    片岡 良浩, 山内 健介, 小田島 健二, 井本 和宏, 北村 淳, 飯久保 正弘, 小山 重人, 高橋 哲

    日本口腔インプラント学会誌　32　(特別号)　349-349　2019/09

    Publisher: (公社)日本口腔インプラント学会

    ISSN： 0914-6695

    eISSN： 2187-9117

  17. 当科における過去5年間の口腔扁平上皮癌N0症例の臨床的検討

    武田 裕利, 黒羽根 壮, 宮下 仁, 纐纈 衆, 北村 淳, 斎藤 博紀, 田代 和樹, 柳沢 佑太, 井本 和宏, 黒田 佳奈子, 齊藤 志郎, 森 士朗, 永井 宏和, 山内 健介, 高橋 哲

    頭頸部癌　45　(2)　217-217　2019/05

    Publisher: (一社)日本頭頸部癌学会

    ISSN： 1349-5747

    eISSN： 1881-8382

  18. 当院歯科インプラントセンターにおけるサイナスリフト・ソケットリフトの臨床的検討

    井本 和宏, 片岡 良浩, 齊藤 博紀, 依田 信裕, 山内 健介, 小山 重人, 高橋 哲

    Japanese Journal of Maxillo Facial Implants　17　(3)　279-279　2018/11

    Publisher: (公社)日本顎顔面インプラント学会

    ISSN： 1347-894X

    eISSN： 2433-5509

  19. 当科における過去4年間の口腔扁平上皮癌NO症例の臨床的検討

    黒羽根 壮, 宮下 仁, 永井 宏和, 山内 健介, 森 士朗, 川井 忠, 北村 淳, 纐纈 衆, 齊藤 博紀, 田代 和樹, 柳沢 佑太, 井本 和宏, 黒田 佳奈子, 齊藤 志都

    頭頸部癌　44　(2)　233-233　2018/05

    Publisher: (一社)日本頭頸部癌学会

    ISSN： 1349-5747

    eISSN： 1881-8382

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Research Projects 1

  1. 顎堤委縮に対する形状記憶フレーム装置を用いた新規Dynamic GBR法の開発

    井本 和宏

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 若手研究

    Institution: 東北大学

    2025/04/01 - 2028/03/31