Details of the Researcher

PHOTO

Takuma Sato
Section
Tohoku University Hospital
Job title
Senior Assistant Professor
Degree

  • 博士（医学）（東北大学）

e-Rad No.
80804856

Research Areas 1

  • Life sciences / Urology /

Papers 52

  1. Trends in the use and efficacy of adjuvant immunotherapy in muscle-invasive urothelial carcinoma. International-journal

    Shingo Hatakeyama, Naoki Fujita, Mizuki Kobayashi, Shuya Kandori, Daiki Ikarashi, Hiroki Fukuhara, Takuma Sato, Shingo Myoen, Motohide Uemura, Takamitsu Inoue, Masaaki Oikawa, Yasuhiro Kaiho, Jun Miyazaki, Yoshiyuki Kojima, Hisanobu Adachi, Akihiro Ito, Norihiko Tsuchiya, Wataru Obara, Hiroyuki Nishiyama, Tomonori Habuchi, Chikara Ohyama

    Scientific reports　15　(1)　25247-25247　2025/07/12

    DOI： 10.1038/s41598-025-11319-w 　

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    We investigated trends in the use of perioperative therapy and the efficacy of adjuvant immunotherapy on the prognosis of patients with muscle-invasive urothelial carcinoma (MIUC). The usage and trends in neoadjuvant and adjuvant therapy were examined, and the efficacy of adjuvant immunotherapy was assessed using propensity score-adjusted Cox multivariate analysis. We investigated 1383 patients with muscle-invasive bladder cancer and 1124 patients with upper tract urothelial carcinoma; 1095 (43.7%) patients received neoadjuvant therapy and 366 (14.6%) patients received adjuvant therapy. Adjuvant therapy usage rate increased from 30.3% before 2022 to 61% after 2022 in patients with pathological high-risk cancer (pT3-4, ypT2-4, or pN+). The adjuvant immunotherapy usage rate increased from 2.8% before 2022 to 67.5% after 2022. Sixty-three (18.9%) of the 334 patients with pathological high-risk cancer who were treated with adjuvant therapy were treated with adjuvant immunotherapy. The propensity score-adjusted Cox multivariate analysis showed that adjuvant immunotherapy significantly improved disease-free survival (Hazard ratios (HR) 0.39, P < 0.005) and overall survival (HR 0.20, P < 0.005) compared with conventional adjuvant chemotherapy. In conclusion, the introduction of adjuvant immunotherapy led to the increased use of adjuvant therapy and improved prognoses in patients with MIUC in real-world practice.

  2. Course of Multimodal Therapy and Genetic Profile of HLRCC with Early Recurrence During Adjuvant Therapy After Radical Nephrectomy. International-journal

    Hiroshi Masuda, Tomonori Sato, Satoko Sato, Takuro Goto, Hiromichi Katayama, Yohei Satake, Takuma Sato, Yoshihide Kawasaki, Naoki Kawamorita, Hidekazu Shirota, Akihiro Ito

    Urologia internationalis　1-9　2025/07/12

    DOI： 10.1159/000547393 　

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    Introduction Fumarate hydratase-deficient renal cell carcinoma is a rare and aggressive subtype associated with hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome, characterized by germline mutations in the fumarate hydratase (FH) gene. Here, we report a case of HLRCC with early recurrence during adjuvant therapy following radical nephrectomy. Case presentation A 34-year-old woman with FH-deficient RCC presented with fever, right flank pain, and a large renal mass with a tumor thrombus. Open radical nephrectomy and IVC tumor thrombectomy were performed. Pathological findings and genetic analyses confirmed the diagnosis of HLRCC. Despite adjuvant pembrolizumab therapy after nephrectomy, bone metastases were detected within nine weeks. The patient was treated with stereotactic body radiotherapy (SBRT), followed by systemic therapy with nivolumab and cabozantinib. After 16 months since the recurrence, no further disease progression was observed. Genetic counseling revealed the same FH mutation in her daughter, prompting annual surveillance. Conclusion This case highlights the potential efficacy of combining tyrosine kinase inhibitor therapy with SBRT in managing aggressively progressive HLRCC.

  3. Effect of imipramine on ejaculatory dysfunction in a rat hypogastric nerve injury model. International-journal

    Kunihisa Nezu, Shinichi Yamashita, Juntaro Koyama, Takuro Goto, Yu Suzuki, Takuma Sato, Yoshihide Kawasaki, Naoki Kawamorita, Akihiro Ito

    The journal of sexual medicine　2025/05/02

    DOI： 10.1093/jsxmed/qdaf092 　

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    BACKGROUND: Peripheral sympathetic nerve injury, resulting from surgery around the abdominal aorta, including retroperitoneal lymph node dissection for testicular cancer, often causes ejaculatory dysfunction (EjD). EjD reduces sexual activity and male fertility. Imipramine (IMI) has been empirically used for EjD. However, research using animal models and clinical studies on EjD is limited. AIM: We investigated the effects of IMI in a rat model of EjD following hypogastric nerve (HGN) injury using apomorphine (APO)-induced ejaculations and lumbar splanchnic nerve (LSN) electrostimulation. METHODS: Thirty-six male Sprague-Dawley rats were divided into six groups: Sham, Sham-IMI, Crush-Vehicle, Crush-IMI, Cut-Vehicle, and Cut-IMI. In the Crush group, the bilateral HGNs were crushed, and in the Cut group, the bilateral HGNs were excised. IMI (1 mg/kg) or Vehicle was administered intraperitoneally 7-30 days after HGN injury. OUTCOMES: Ejaculatory function was assessed weekly using the weight of solid semen ejaculated from the urethral meatus after subcutaneous administration of 0.5 mg/kg APO. Changes in seminal vesicle pressure (SVP) were assessed using APO-induced ejaculation (ΔSVPA) and LSN electrostimulation (ΔSVPE) 30 days after HGN injury. Dunnett's test was used to determine significant differences between groups. RESULTS: In the Crush-IMI group, the mean solid semen weights significantly increased 21 and 28 days after HGN injury compared with those in the Crush-Vehicle group (P = .011 and P = .036, respectively). However, in the Cut-IMI group, no increase in solid semen weight was observed. The ΔSVPA in the Crush-IMI group was higher than that in the Crush-Vehicle group; however, the difference was not statistically significant. Furthermore, ΔSVPE in the Crush-IMI group was significantly higher than that in the Crush-Vehicle group (P = .024). Additionally, the mean seminal vesicle weights in the Crush-IMI group were lower than those in the Crush-Vehicle group at 30 days after HGN injury (P = .014). CLINICAL IMPLICATIONS: IMI improves SV function, suggested that IMI might be useful in patients with EjD. STRENGTHS AND LIMITATIONS: This study shows that IMI has an effect on EjD by improving SV function in a rat model. Limitations include a lack of the mechanisms or the effect of IMI at different doses on EjD. CONCLUSION: This model allowed for the comprehensive assessment of EjD in rats, and IMI attenuated EjD after HGN injury. It aids in the clarification of the mechanism and development of treatments for nerve injury-related EjD.

  4. Association Between Daily Mode of Transportation and Cognitive Function Among Older Adults With Mild Cognitive Impairment: A Cross-Sectional Observational Study. International-journal

    Teruaki Masuda, Emiko Segawa, Noriyuki Kimura, Takuma Sato, Kenichi Anabuki, Yoshitaka Nakamura, Shigenobu Mitsuzawa, Satoru Shinkawa, Ken Aoshima, Etsuro Matsubara

    Cureus　17　(4)　e83021　2025/04

    DOI： 10.7759/cureus.83021 　

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    Background Changes in mode of transportation, such as driving cessation, elevate the risk of mild cognitive impairment (MCI) and Alzheimer's disease among older adults residing in communities. However, the association between transportation-related lifestyles and cognitive function in older adults with MCI remains unclear. This study aimed to explore the relationship between mobility independence and cognitive dysfunction among older patients with MCI. Methods This was a retrospective study of community-dwelling adults aged 65 years or older from Usuki, Oita Prefecture, Japan. Data from 117 participants with MCI were analyzed. Using the Lawton Instrumental Activities of Daily Living scale, participants were categorized into independent and dependent mobility groups based on their mode of transportation. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) and the Japanese version of the Montreal Cognitive Assessment (MoCA-J), and scores were compared across modes of transportation. Results Significant differences were found in total MoCA-J scores, visuospatial executive function, naming, and orientation, and MMSE orientation of time and place, with higher scores observed in the independent mobility group compared to the dependent group (p < 0.05). Analysis of covariance further supported these findings, showing higher scores in total MoCA-J and MMSE scores in the independent mobility group. Conclusions This study highlights the relationship between daily mode of transportation and cognitive function in patients with MCI. Participants with independent mobility exhibited superior cognitive function compared to the dependent mobility group. These findings may contribute to the development of new interventions for preventing the transition from MCI to dementia by further validation of causal relationships in longitudinal or intervention studies.

  5. A severe case of the bladder inversion treated by total cystectomy and hysterectomy with ileal conduit. International-journal

    Taro Akai, Naoki Kawamorita, Tetsuro Shiraiwa, Mahoro Watanabe, Tomonori Sato, Takuma Sato, Emi Yokoyama, Masumi Ishibashi, Zen Watanabe, Akihiro Ito

    IJU case reports　8　(2)　85-88　2025/03

    DOI： 10.1002/iju5.12795 　

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    INTRODUCTION: Female pelvic organ prolapse (POP) is considered a borderline disease between urology and gynecology and is treated by reconstructive surgery, which restores the organs to their original positions. CASE PRESENTATION: An 82-year-old woman with bladder and uterine prolapse at POP-Q Stage IV was treated with an indwelling catheter for voiding dysfunction. Eventually, the catheter has been often spontaneously removed when pelvic organ prolapse occurs, resulting in a diagnosis of bladder inversion. Because of bladder inversion and low bladder capacity at the time of bladder retraction, the patient underwent total cystectomy, combined with total hysterectomy, colpopexy, and posterior colporraphy, and ileal conduit. CONCLUSION: The cases of complete bladder and uterine prolapse combined with bladder inversion, total hysterectomy, colpopexy, posterior colporraphy, and ileal conduit were performed safely. Considering urinary function, surgery without organ preservation with urinary diversion may be an option.

  6. Immune-Related Fulminant Myocarditis Revealed Using Myocardial Histopathology at Autopsy in the Treatment of Advanced Renal Cell Carcinoma: A Case Report. International-journal

    Yuka Hayashi, Yoshihide Kawasaki, Hiromichi Katayama, Rie Sakagami, Takuro Goto, Tomonori Sato, Yohei Satake, Takuma Sato, Naoki Kawamorita, Shinichi Yamashita, Hiroyuki Takahama, Satoko Sato, Akihiro Ito

    Case reports in oncology　18　(1)　738-743　2025

    DOI： 10.1159/000546288 　

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    INTRODUCTION: Although immune checkpoint inhibitor-associated myocarditis is relatively rare, it has the highest mortality rate among all immune-related adverse events, at 30-50%. CASE PRESENTATION: We encountered a case of advanced renal cancer in which immune checkpoint inhibitor-associated myocarditis was confirmed on autopsy. A 78-year-old man was diagnosed with a left renal tumor secondary to hematuria. A tumor biopsy was performed, and the tumor was diagnosed as cT4N0M1 clear cell renal carcinoma, which was classified as poor risk by the International mRCC Database Consortium. Combination therapy with pembrolizumab and axitinib was initiated. One month later, the patient developed anorexia, dizziness, and fatigue, which were judged to be adverse events due to systemic therapy, and the patient was admitted to the hospital urgently. After admission, the patient experienced a sudden drop in blood pressure and loss of consciousness and was referred to a cardiologist for treatment. Blood tests showed elevated brain-type natriuretic peptide levels, but echocardiography showed good cardiac function. However, soon thereafter, the patient developed tachycardia, and echocardiography revealed a significant decline in systolic function, leading to the diagnosis of immune checkpoint inhibitor-associated myocarditis. Despite intensive care in the cardiac high-care unit and steroid administration, the patient died. An autopsy revealed necrotic changes in the myocardium, loss of myocardial cells, and severe lymphocyte infiltration, leading to a diagnosis of inhibitor-associated myocarditis. CONCLUSION: Delay in the initiation of treatment is considered a risk factor for poor prognosis, and the administration of high-dose steroids within 24 h of onset contributes to a better outcome. Herein, we discuss the pathology, diagnosis, and treatment of immune checkpoint inhibitor-associated myocarditis.

  7. Enfortumab Vedotin-Induced Diabetic Ketoacidosis and Acute Tubulointerstitial Nephritis Requiring Intensive Care in the Treatment of Advanced Urothelial Carcinoma: A Case Report. International-journal

    Ryo Matsui, Yoshihide Kawasaki, Yohei Satake, Kei Takahashi, Satoko Kurosawa, Tomonori Sato, Hiromichi Katayama, Takuma Sato, Naoki Kawamorita, Shinichi Yamashita, Hideki Katagiri, Akihiro Ito

    Case reports in oncology　18　(1)　667-674　2025

    DOI： 10.1159/000545957 　

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    INTRODUCTION: Enfortumab vedotin (EV) has been approved for the treatment of many types of cancer, and its use is still expanding. It is an essential drug used as a standard treatment for advanced and metastatic urothelial carcinoma but is known to cause various adverse events (AEs). CASE PRESENTATION: We report a patient with metastatic urothelial carcinoma who experienced multiple AEs associated with diabetic ketoacidosis (DKA) during EV treatment. The onset of DKA during EV treatment has been reported to be associated with poor prognosis. Although strict management was required in the intensive care unit, we were able to save the patient's life. CONCLUSION: Although the detailed mechanism that induced insulin resistance remains unclear, the patient required high-dose insulin because of a marked increase in insulin resistance. If hyperglycemia is observed during EV therapy, DKA may lead to the occurrence of serious AEs. We report on the pathogenesis and management of drug-induced DKA caused by EV based on our case and a literature review.

  8. Ultrasound irradiation in the presence of microbubbles may enhance the antitumor effect of chemotherapeutic agents against bladder cancer. International-journal

    Takehiro Suzuki, Takuma Sato, Ariunbuyan Sukhbaatar, Maya Sakamoto, Shiro Mori, Tetsuya Kodama, Akihiro Ito

    Journal of Cancer　16　(2)　368-381　2025

    DOI： 10.7150/jca.100846 　

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    Intravesical instillation of chemotherapy has been performed to reduce the risk of intravesical recurrence of bladder cancer. However, its antitumor effect is not necessarily sufficient, which may be partially due to inadequate delivery of intravesically administered chemotherapeutic agents to bladder tumors. Ultrasound irradiation to target tissues in the presence of microbubbles is a technique to transiently enhance cell membrane permeability and achieve efficient drug delivery to the desired sites without damage to non-target areas; this technique has been used in chemotherapy, immunotherapy, gene therapy, and radiotherapy for the treatment of various cancers. However, the effectiveness of combining intravesical instillation of chemotherapy and this strategy for the treatment of bladder cancer has not been fully investigated. This report shows that mitomycin C combined with ultrasound and microbubbles has a higher antitumor effect than mitomycin C alone against mouse bladder cancer cells. Next, the antitumor effect of intravesical instillation of chemotherapy combined with ultrasound and microbubbles was demonstrated using an orthotopic mouse bladder cancer model. In vivo experiments showed that ultrasound irradiation in the presence of microbubbles enhanced the local delivery of fluorescent molecules and had the potential to enhance the antitumor effect of intravesical instillation of chemotherapy without visible damage to the surrounding normal tissues. The results of the present study demonstrate that intravesical chemotherapy combined with ultrasound and microbubbles is potentially a safe and effective treatment for bladder cancer.

  9. [Clinical Study of Lymph Node Dissection in Robot-Assisted Radical Prostatectomy for High-Risk Prostate Cancer].

    Shotaro Hatano, Takayuki Goto, Jin Kono, Takayuki Sumiyoshi, Kimihiko Masui, Takuma Sato, Takeshi Sano, Atsuro Sawada, Shusuke Akamatsu, Takahiro Inoue, Osamu Ogawa, Takashi Kobayashi

    Hinyokika kiyo. Acta urologica Japonica　70　(11)　367-372　2024/11

    DOI： 10.14989/ActaUrolJap_70_11_367 　

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    We retrospectively analyzed the regions and perioperative outcomes associated with lymph node dissection in patients with prostate cancer. Of 543 patients who underwent robot-assisted radical prostatectomy for prostate cancer with or without lymph node dissection according to the modified D'Amico criteria, 333 (61.3%), 128 (23.6%), and 82 (15.1%) were classified into the non-dissection, limited dissection, and extended dissection groups, respectively. Lymph node metastasis was identified in eight patients : one in the limited dissection group and seven in the extended dissection group. Notably, all eight biopsies showed Gleason scores of 4＋4 or higher, and the initial prostate-specific antigen (PSA) concentration was ≥10 ng/ml in seven of these patients. Lymph node metastasis was detected in areas other than the obturator lymph nodes in five patients (62.5%). Although there was no significant difference in the rate of Clavien- Dindo grade ≥II complications among the three groups, six patients (7.3%) in the extended dissection group developed infectious lymphoceles. In the extended dissection group, the PSA progression-free survival (PSA-PFS) was significantly shorter in patients with than in those without lymph node metastasis (p＜0.001). Because lymph node metastases were rare in the limited dissection group in our cohort of patients with a high risk of localized prostate cancer, achieving a diagnosis seems difficult with limited dissection. By contrast, in the extended dissection group, the PSA-PFS prognosis was significantly worse in lymph node-positive cases. Therefore, considering the high complication risk of lymphoceles, extended dissection should be performed in patients with a high likelihood of lymph node metastasis.

  10. Distant recurrence of non-muscle invasive bladder cancer 8 years after initial treatment. International-journal

    Mahoro Watanabe, Naoki Kawamorita, Tetsuro Shiraiwa, Tomonori Sato, Takuma Sato, Yoshihide Kawasaki, Shinichi Yamashita, Akiko Ebata, Satoko Sato, Akihiro Ito

    IJU case reports　7　(6)　448-453　2024/11

    DOI： 10.1002/iju5.12775 　

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    INTRODUCTION: Distant recurrence of non-muscle invasive bladder cancer is a rare condition that is poorly understood and difficult to detect in follow-up protocols. CASE PRESENTATION: A 73-year-old female with a history of T1N0M0 bladder cancer 8 years ago suffered from a left axillary tumor, a left lung tumor, left mediastinal lymph node swelling, and bilateral adrenal gland tumors. Initially, she was diagnosed with metastatic left breast cancer of the left accessory mamma by needle biopsy of an axillary tumor. Subsequent bronchoscopic biopsy of the mediastinal lymph node revealed metastatic urothelial carcinoma, although no recurrence was detected in the urinary tract. She underwent systemic therapy, and all regions shrank without reprogression. CONCLUSION: Non-muscle invasive bladder cancer should be managed considering distant metastasis. If the origin of the metastatic lesions is unknown, this disease should be considered as a possible origin, even in the absence of urinary tract recurrence.

  11. Assessment of Clinicopathological Characteristics and Clinical Outcomes of Patients who Developed Non-Muscle-Invasive Bladder Cancer after Radiotherapy for Prostate Cancer: A Retrospective Multicenter Study.

    Takuma Sato, Takeshi Sano, Hisanobu Adachi, Yoshihiro Ikeda, Jun Takemoto, Shingo Myoen, Koji Mitsuzuka, Atsushi Kyan, Hiroshi Aoki, Satoru Tokuyama, Hideo Saito, Shinichi Yamashita, Yoichi Arai, Takashi Kobayashi, Akihiro Ito

    The Tohoku journal of experimental medicine　2024/10/17

    DOI： 10.1620/tjem.2024.J109 　

  12. Outcomes of active surveillance for Japanese patients with prostate cancer (PRIAS-JAPAN). International-journal

    Takuma Kato, Ryuji Matsumoto, Akira Yokomizo, Yoichiro Tohi, Hiroshi Fukuhara, Yoichi Fujii, Keiichiro Mori, Takuma Sato, Junichi Inokuchi, Katsuyoshi Hashine, Shinichi Sakamoto, Hidefumi Kinoshita, Koji Inoue, Toshiki Tanikawa, Takanobu Utsumi, Takayuki Goto, Isao Hara, Hiroshi Okuno, Yoshiyuki Kakehi, Mikio Sugimoto

    BJU international　2024/06/17

    DOI： 10.1111/bju.16436 　

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    OBJECTIVE: To report the outcomes of repeat biopsies, metastasis and survival in the Prostate Cancer Research International: Active Surveillance (PRIAS)-JAPAN study, a prospective observational study for Japanese patients, initiated in 2010. PATIENTS AND METHODS: At the beginning, inclusion criteria were initially low-risk patients, prostate-specific antigen (PSA) density (PSAD) <0.2, and ≤2 positive biopsy cores. As from 2014, GS3+4 has also been allowed for patients aged 70 years and over. Since January 2021, the age limit for Gleason score (GS) 3 + 4 cases was removed, and eligibility criteria were expanded to PSA ≤20 ng/mL, PSAD <0.25 nd/mL/cc, unlimited number of positive GS 3 + 3 cores, and positive results for fewer than half of the total number of cores for GS 3 + 4 cases if magnetic resonance imaging fusion biopsy was performed at study enrolment or subsequent follow-up. For patients eligible for active surveillance, PSA tests were performed every 3 months, rectal examination every 6 months, and biopsies at 1, 4, 7 and 10 years, followed by every 5 years thereafter. Patients with confirmed pathological reclassification were recommended for secondary treatments. RESULTS: As of February 2024, 1302 patients were enrolled in AS; 1274 (98%) met the eligibility criteria. The median (interquartile range) age, PSA level, PSAD, and number of positive cores were 69 (64-73) years, 5.3 (4.5-6.6) ng/mL, 0.15 (0.12-0.17) ng/mL, and 1 (1-2), respectively. The clinical stage was T1c in 1089 patients (86%) and T2 in 185 (15%). The rates of acceptance by patients for the first, second, third and fourth re-biopsies were 83%, 64%, 41% and 22%, respectively. The pathological reclassification rates for the first, second, third and fourth re-biopsies were 29%, 30%, 35% and 25%, respectively. The 1-, 5- and 10-year persistence rates were 77%, 45% and 23%, respectively. Six patients developed metastasis, and one patient died from prostate cancer. CONCLUSION: Pathological reclassification was observed in approximately 30% of the patients during biopsy; however, biopsy acceptance rates decreased over time. Although metastasis occurred in six patients, only one death from prostate cancer was recorded.

  13. A case of testicular tumor and respiratory failure caused by choriocarcinoma syndrome managed through modified chemotherapy and extracorporeal membrane oxygenation International-journal

    Tetsuro Shiraiwa, Hiromichi Katayama, Yudai Iwasaki, Shingo Kimura, Yohei Satake, Takuma Sato, Yoshihide Kawasaki, Naoki Kawamorita, Shinichi Yamashita, Akihiro Ito

    IJU Case Reports　7　(4)　285-288　2024

    DOI： 10.1002/iju5.12725 　

    eISSN： 2577-171X

  14. The impact of second transurethral resection on survival outcomes in patients with non-muscle-invasive bladder cancer treated with bacillus Calmette-Guérin therapy. International-journal

    Hiroshi Kikuchi, Takashige Abe, Makito Miyake, Haruka Miyata, Ryuji Matsumoto, Takahiro Osawa, Nobutaka Nishimura, Kiyohide Fujimoto, Junichi Inokuchi, Takahiro Yoneyama, Ryotaro Tomida, Kazuyuki Numakura, Yuto Matsushita, Kazumasa Matsumoto, Takuma Sato, Rikiya Taoka, Takashi Kobayashi, Takahiro Kojima, Yoshiyuki Matsui, Naotaka Nishiyama, Hiroshi Kitamura, Hiroyuki Nishiyama, Nobuo Shinohara

    Japanese journal of clinical oncology　2023/11/16

    DOI： 10.1093/jjco/hyad155 　

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    OBJECTIVE: Several guidelines recommended that second transurethral resection should be performed in patients with diagnosis of high-risk non-muscle-invasive bladder cancer. However, therapeutic benefits of second transurethral resection before bacillus Calmette-Guérin intravesical instillation were conflicting amongst previous studies. We investigated the prognostic impact of second transurethral resection before bacillus Calmette-Guérin instillation in high-risk non-muscle-invasive bladder cancer patients. METHODS: This retrospective study included 3104 non-muscle-invasive bladder cancer patients who received bacillus Calmette-Guérin instillations between 2000 and 2019 at 31 collaborative institutions. Univariate and multivariate Cox proportional hazards models were used to assess the risk factors of intravesical recurrence, disease progression, cancer-specific mortality and overall mortality. RESULTS: In the entire population, patients undergoing second transurethral resection (33%, 1026/3104) had a lower risk of intravesical recurrence on univariate analysis (hazard ratio 0.85, 95% confidence interval 0.73-0.98, P = 0.027), although it did not remain significant on multivariate analysis (hazard ratio 0.90, 95% confidence interval 0.76-1.07, P = 0.24). Subgroup analysis revealed that, in pT1 patients (n = 1487), second transurethral resection was significantly correlated with a lower risk of intravesical recurrence on multivariate analysis (hazard ratio 0.80, 95% confidence interval 0.64-1.00, P = 0.048), but lower risks of disease progression (hazard ratio 0.75, 95% confidence interval 0.56-1.00, P = 0.049), cancer-specific mortality (hazard ratio 0.54, 95% confidence interval 0.35-0.85, P = 0.007) and overall mortality (hazard ratio 0.73, 95% confidence interval 0.55-0.97, P = 0.027) on univariate analysis. CONCLUSIONS: Second transurethral resection confers accurate pathological staging and could be used to safely select good candidates for intravesical bacillus Calmette-Guérin instillation. We further confirm that second transurethral resection could confer an oncological benefit in pT1 bladder cancer patients treated by bacillus Calmette-Guérin instillation, and so strongly recommend second transurethral resection in this patient population.

  15. Improving compliance with guidelines may lead to favorable clinical outcomes for patients with non-muscle-invasive bladder cancer: A retrospective multicenter study. International-journal

    Takuma Sato, Takeshi Sano, Sadafumi Kawamura, Yoshihiro Ikeda, Kazuhiko Orikasa, Takaki Tanaka, Atsushi Kyan, Shozo Ota, Satoru Tokuyama, Hideo Saito, Koji Mitsuzuka, Shinichi Yamashita, Yoichi Arai, Takashi Kobayashi, Akihiro Ito

    International journal of urology : official journal of the Japanese Urological Association　2023/09/04

    DOI： 10.1111/iju.15294 　

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    OBJECTIVES: Clinical guidelines recommend that patients with non-muscle-invasive bladder cancer (NMIBC) should be treated with appropriate adjuvant therapy. However, compliance with guideline recommendations is insufficient, and this may lead to unfavorable outcomes. We aimed to investigate the level of adherence to guideline recommendations in patients with NMIBC and evaluate the outcomes of those who did and did not receive guideline-recommended therapies. METHODS: We performed a retrospective analysis of patients with histologically diagnosed NMIBC. The percentage of patients with intermediate- and high-risk tumors who received adjuvant intravesical therapy or second transurethral resection (TUR) was calculated. Recurrence-free survival was assessed in patients who did and did not receive the therapies. We conducted a propensity score-matched analysis to compare outcomes between patients with intermediate-risk and T1 NMIBC who did and did not undergo guideline-recommended therapies. RESULTS: Overall, 1204 patients from the Tohoku Urological Evidence-Based Medicine Study Group and Kyoto University Hospital were included. Of patients with intermediate- and high-risk tumors, 91.0% and 74.0% did not receive maintenance bacillus Calmette-Guérin (BCG), respectively. In both groups, significantly better recurrence-free survival was found for patients treated with maintenance BCG. Among patients with T1 NMIBC, only 16.7% underwent guideline-recommended therapies, that is, a second TUR and maintenance BCG. Significantly greater recurrence-free survival was observed in patients who received guideline-recommended therapies compared with propensity-matched patients who did not. CONCLUSIONS: Guideline-recommended therapies may contribute to improvements in outcomes for patients with NMIBC, suggesting that improvements in adherence to clinical guidelines may lead to favorable outcomes.

  16. A case of testicular cancer with retroperitoneal lymph node metastasis of teratoma with somatic-type malignancy 18 years after initial treatment. International-journal

    Maiko Yamashita, Takanari Sakai, Shinichi Yamashita, Fumiyoshi Fujishima, Takuro Goto, Takuma Sato, Yoshihide Kawasaki, Naoki Kawamorita, Takaki Tanaka, Akihiro Ito

    IJU case reports　6　(4)　226-229　2023/07

    DOI： 10.1002/iju5.12593 　

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    INTRODUCTION: In testicular cancer, late relapse of teratoma with somatic-type malignancy is rare and associated with a poor survival. A case of retroperitoneal lymph node metastasis of teratoma with somatic-type malignancy 18 years after initial treatment for testicular cancer is reported. CASE PRESENTATION: A 46-year-old man had a 15-mm-sized mass in the para-aortic region 18 years after initial treatment for testicular cancer, without elevated serum alfa-fetoprotein or human chorionic gonadotropin levels. Laparoscopic retroperitoneal lymph node dissection was performed. The pathological findings showed teratoma with somatic-type malignancy, and the findings of primary testicular cancer reported a yolk sac tumor, not teratoma. CONCLUSION: Late relapse of teratoma with somatic-type malignancy was resected by laparoscopic retroperitoneal lymph node dissection. Therefore, long-term follow-up should be considered if patients with small retroperitoneal masses did not undergo retroperitoneal lymph node dissection, and early detection and surgical resection for relapse might be effective.

  17. マウス膀胱がんモデルに対する、微小気泡と超音波を併用した抗がん剤の膀胱注入療法の治療効果の解析(The combination of vesical instillation of chemotherapy with ultrasound and nanobubbles is efficient against experimental tumors in murine bladder cancer model)

    鈴木 健大, 佐藤 琢磨, アリウンブヤン・スフバートル, 阪本 真弥, 森 士朗, 小玉 哲也, 伊藤 明宏

    日本泌尿器科学会総会　110回　AOP06-08　2023/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  18. 筋層非浸潤性膀胱がんに対する術後膀胱内注入療法および2nd TURの治療効果について(Recurrence-free survival in patients with non-muscle invasive bladder cancer who received adjuvant intravesical therapy and second transurethral resection)

    佐藤 琢磨, 田中 峻希, 折笠 一彦, 齋藤 英郎, 池田 義弘, 徳山 聡, 喜屋武 淳, 川村 貞文, 太田 章三, 小林 恭, 小川 修, 伊藤 明宏

    日本泌尿器科学会総会　110回　OP41-05　2023/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  19. 東北大学病院における進行腎細胞癌に対する1次療法の選択に関する検討(Selection of first-line therapy for advanced renal cell carcinoma at Tohoku University Hospital)

    坂井 孝成, 川崎 芳英, 諸角 謙人, 方山 博路, 嶋田 修一, 佐藤 琢磨, 佐竹 洋平, 川守田 直樹, 山下 慎一, 伊藤 明宏

    日本泌尿器科学会総会　110回　OP63-01　2023/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  20. 前立腺生検で診断された下垂体と前立腺に病変を有するIgG4関連疾患の一例

    佐藤 泰史, 佐藤 琢磨, 鈴木 悠, 村川 裕希, 佐竹 洋平, 川崎 芳英, 川守田 直樹, 山下 慎一, 伊藤 明宏, 手塚 雄太, 棚橋 善克

    泌尿器外科　36　(4)　357-357　2023/04

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  21. Considerations for safe laparoscopic renal biopsy

    川崎芳英, 森本玲, 手塚雄太, 尾股慧, 小野美澄, 山崎有人, 方山博路, 佐竹洋平, 嶋田修一, 佐藤琢磨, 川守田直樹, 山下慎一, 宮崎真理子, 田中哲洋, 鈴木貴, 佐藤文俊, 笹野公伸, 伊藤明宏

    Japanese Journal of Endourology and Robotics (Web)　36　(1)　124-128　2023/04

    Publisher:

    ISSN： 2436-875X

    eISSN： 2436-875X

  22. Cohen法術後の成人にて内視鏡操作が困難であった2例

    宇佐見毅, 武田詩奈子, 久保田優花, 城之前翼, 相野谷慶子, 坂井清英, 佐藤琢磨, 伊藤明宏

    日本逆流性腎症フォーラム記録集　29th　39-42　2023

    Publisher: 日本逆流性腎症フォーラム

    ISSN： 2435-323X

  23. Laparoscopic radical nephrectomy for renal cell carcinoma with renal venous thrombus from the viewpoint of safety and certainty

    川崎芳英, 川守田直樹, 方山博路, 佐竹洋平, 佐藤琢磨, 嶋田修一, 山下慎一, 伊藤明宏

    泌尿器外科　36　(臨増)　745-749　2023

    Publisher:

    ISSN： 0914-6180

  24. NMIBC治療:Next generationをズバリ予想する

    佐藤琢磨

    日本泌尿器科学会東部総会プログラム・抄録集　88th (CD-ROM)　2023

  25. Contemplation of the Effect of Nivolumab Plus Cabosantinib Therapy on Cerebral Hemorrhage in Patients with Brain Metastasis of Renal Cell Carcinoma: A Case Report. International-journal

    Yasufumi Sato, Yoshihide Kawasaki, Yohei Satake, Yoshiteru Shimoda, Hiromichi Katayama, Takuma Sato, Shuichi Shimada, Naoki Kawamorita, Shinichi Yamashita, Masayuki Kanamori, Akihiro Ito

    Case reports in oncology　16　(1)　1573-1578　2023

    DOI： 10.1159/000533785 　

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    Although the response to combination therapy has been reported in patients with brain metastases from advanced renal cancer, treatment-related cerebral hemorrhage has not been adequately studied. The CheckMate 9ER clinical trial of nivolumab and cabozantinib excluded patients with brain metastases. Therefore, the associated treatment outcomes in these patients with brain metastases are unclear. Herein, we report a case of bleeding from brain metastases in a patient with advanced renal cancer after gamma knife combination therapy with nivolumab and cabozantinib. Fortunately, the cerebral hemorrhage of the patient was alleviated by conservative treatment. Despite treatment interruption, the metastatic lesions reduced in size, and treatment was gradually resumed. In this case study, we report the risk of cerebral hemorrhage in combination therapy for brain metastasis cases, how to manage hemorrhage cases, and their prognosis.

  26. Impact of Adrenalectomy on Diastolic Cardiac Dysfunction in Patients with Primary Aldosteronism.

    Kunihisa Nezu, Yoshihide Kawasaki, Ryo Morimoto, Yoshikiyo Ono, Kei Omata, Yuta Tezuka, Shuichi Shimada, Youhei Satake, Hiromichi Katayama, Takuma Sato, Naoki Kawamorita, Shinichi Yamashita, Hiroyuki Takahama, Koji Mitsuzuka, Fumitoshi Satoh, Akihiro Ito

    The Tohoku journal of experimental medicine　2022/12/29

    DOI： 10.1620/tjem.2022.J117 　

  27. Low-energy shock wave therapy ameliorates ischemic-induced overactive bladder in a rat model. International-journal

    Shingo Kimura, Naoki Kawamorita, Yoku Kikuchi, Tomohiko Shindo, Yuichi Ishizuka, Yoichi Satake, Takuma Sato, Hideaki Izumi, Shinichi Yamashita, Satoshi Yasuda, Hiroaki Shimokawa, Akihiro Ito

    Scientific reports　12　(1)　21960-21960　2022/12/19

    DOI： 10.1038/s41598-022-26292-x 　

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    This study was to evaluate whether Low-energy shock wave therapy (LESW) improves ischemic-induced overactive bladder in rats and investigate its therapeutic mechanisms. Sixteen-week-old male Sprague-Dawley rats were divided into three groups: arterial injury (AI), AI with LESW (AI-SW), and control groups. LESW was irradiated in AI-SW during 20-23 weeks of age. At 24 weeks of age, conscious cystometry was performed (each n = 8). The voiding interval was shortened in AI (mean ± SEM: 5.1 ± 0.8 min) than in control (17.3 ± 3.0 min), whereas significant improvements were observed in AI-SW (14.9 ± 3.3 min). The bladder blood flow was significantly increased in AI-SW than in AI. Microarray analysis revealed higher gene expression of soluble guanylate cyclase (sGC) α1 and β1 in the bladder of AI-SW compared to AI. Protein expression of sGCα1 and sGCβ1 was higher in AI-SW and control groups than in AI. Cyclic guanosine monophosphate (cGMP) was elevated in AI-SW. As an early genetic response, vascular endothelial growth factor and CD31 were highly expressed 24 h after the first LESW. Suburothelial thinning observed in AI was restored in AI-SW. Activation of sGC-cGMP may play a therapeutic role of LESW in the functional recovery of the bladder.

  28. Deliberation on Deferred Cytoreductive Nephrectomy and Postoperative Treatment for Advanced Renal Cell Carcinoma: A Case Report

    Takuya Nakagawa, Yoshihide Kawasaki, Satoko Sato, Hiromichi Katayama, Yohei Satake, Shuichi Shimada, Takuma Sato, Naoki Kawamorita, Shinichi Yamashita, Koji Mitsuzuka, Atsushi Kohyama, Masaharu Ishida, Hideo Ohtsuka, Michiaki Unno, Akihiro Ito

    Case Reports in Oncology　15　(3)　1014-1020　2022/11/08

    Publisher: S. Karger AG

    DOI： 10.1159/000527089 　

    eISSN： 1662-6575

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    In a rare case, free from systemic therapy, deferred cytoreductive nephrectomy was implemented in treating an advanced renal cell carcinoma with liver, lung, and splenic colon metastases. A 59-year-old man diagnosed with advanced renal cell carcinoma underwent deferred cytoreductive nephrectomy due to a partial response to systemic treatment after a period of 1 year. After the surgery, no additional treatment was implemented. Furthermore, after 10 months, the patient had no recurrence of renal cell carcinoma. Through a review of this case and deferred cases in the current literature, we could emphasize the importance of image evaluation and pathological findings as an indication for surgery and subsequent treatment options. However, there is room for debate with regards to the indications for deferred cytoreductive nephrectomy as well as a therapeutic strategy after the surgery. This report discusses the significance of deferred cytoreductive nephrectomy in terms of prognosis and quality-of-life improvement in advanced renal cancer.

  29. ロボット支援腎部分切除術において温阻血時間が術後腎機能に与える影響

    川守田 直樹, 田中 峻希, 方山 博路, 佐竹 洋平, 佐藤 琢磨, 嶋田 修一, 川崎 芳英, 山下 慎一, 伊藤 明宏

    日本泌尿器内視鏡・ロボティクス学会総会　36回　O-2　2022/11

    Publisher: (一社)日本泌尿器内視鏡・ロボティクス学会

  30. A novel missense mutation in the folliculin gene associated with the renal tumor-only phenotype of Birt-Hogg-Dubé syndrome. International-journal

    Takeshi Sano, Tomohiro Fukui, Noriyuki Makita, Kosuke Shimizu, Jin Kono, Kimihiko Masui, Takuma Sato, Takayuki Goto, Atsuro Sawada, Masakazu Fujimoto, Fumiyoshi Kojima, Masako Torishima, Takahito Wada, Mitsuko Furuya, Osamu Ogawa, Takashi Kobayashi, Shusuke Akamatsu

    Cancer genetics　266-267　28-32　2022/08

    DOI： 10.1016/j.cancergen.2022.06.001 　

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    Birt-Hogg-Dubé syndrome is an autosomal dominant disease caused by germline mutations in the folliculin gene (FLCN), characterized by skin fibrofolliculomas, pulmonary cysts, and multiple renal tumors. We report the case of a 51-year-old woman with multiple bilateral renal tumors resected by bilateral open partial nephrectomy. Following pathological diagnosis of hybrid oncocytic/chromophobe tumors, targeted next-generation sequencing of FLCN of the patient's blood revealed a novel missense mutation (c.602A>C, p.Gln201Pro) in exon 6. Sanger sequencing revealed that this mutation was heterozygous. In silico prediction programs consistently indicated the mutation as pathogenic. Western blot analysis and immunohistochemistry revealed suppressed FLCN expression and the upregulation of glycoprotein nonmetastatic B, a downstream target negatively regulated by FLCN, in the tumor tissue, suggesting that the mutation resulted in reduction of functional FLCN expression. Whole-genome sequencing of one of the tumors identified another frameshift mutation in exon 4, suggesting a "second hit" leading to tumorigenesis. We recommend that gene sequencing should be considered in patients with multiple renal tumors to identify their genetic predisposition to renal tumors.

  31. 鑑別が困難であった再発膀胱癌を原発とした続発性外陰部乳房外Paget病の1例

    加藤 淳史, 川崎 芳英, 諸角 謙人, 佐藤 友紀, 林 夏穂, 嶋田 修一, 佐藤 琢磨, 川守田 直樹, 山下 慎一, 三塚 浩二, 渡邊 みか, 星 宣次, 伊藤 明宏

    泌尿器外科　35　(4)　354-354　2022/04

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  32. ラット慢性骨盤虚血モデルにおける低出力衝撃波の有用性と,過活動膀胱治療メカニズムの解明

    木村信吾, 川守田直樹, 石塚雄一, 佐竹洋平, 佐藤琢磨, 泉秀明, 泉秀明, 伊藤明宏

    日本排尿機能学会誌(Web)　33　(1)　208-208　2022

    Publisher: (一社)日本排尿機能学会

    ISSN： 1347-6513

  33. 安全性と確実性を考慮した腎静脈腫瘍塞栓を伴う腎癌に対する腹腔鏡下手術

    川崎芳英, 方山博路, 嶋田修一, 佐藤琢磨, 佐竹洋平, 川守田直樹, 山下慎一, 伊藤明宏

    日本泌尿器科学会東部総会プログラム・抄録集　87th　2022

  34. ペンブロリズマブが著効したMSI-highの去勢抵抗性前立腺癌の1例

    清水浩介, 佐野剛視, 畑野翔太郎, 服部悠斗, 羽間悠祐, 藤原裕士, 河野仁, 増井仁彦, 佐藤琢磨, 後藤祟之, 澤田篤郎, 赤松秀輔, 小林恭, 小川修, 藤本正数

    泌尿器科紀要　68　(12)　398-398　2022

    Publisher: 泌尿器科紀要刊行会

    ISSN： 0018-1994

  35. 陰嚢平滑筋肉腫の1例

    羽間悠祐, 増井仁彦, 清水浩介, 畑野翔太郎, 服部悠斗, 藤原裕士, 河野仁, 佐藤琢磨, 佐野剛視, 後藤崇之, 澤田篤郎, 赤松秀輔, 小林恭, 小川修

    泌尿器科紀要　68　(12)　395-395　2022

    Publisher: 泌尿器科紀要刊行会

    ISSN： 0018-1994

  36. 原発性アルドステロン症における左心室リモデリングと腹腔鏡下副腎摘除術の効果

    祢津晋久, 川崎芳英, 嶋田修一, 佐藤琢磨, 森本怜, 高濱博幸, 川守田直樹, 山下慎一, 伊藤明宏

    日本泌尿器内視鏡・ロボティクス学会(Web)　36th　AP-4　2022

    Publisher: (一社)日本泌尿器内視鏡・ロボティクス学会

  37. 透析腎癌患者における治療モニタリングによるカボザンチニブ血清濃度の検討

    川崎 芳英, 高崎 新也, 前川 正充, 嶋田 修一, 佐竹 洋平, 方山 博路, 佐藤 琢磨, 川守田 直樹, 山下 慎一, 三塚 浩二, 伊藤 明宏

    日本癌治療学会学術集会抄録集　59回　O23-4　2021/10

    Publisher: (一社)日本癌治療学会

  38. A multilocular thymic cyst associated with mediastinal seminoma: evidence for its medullary epithelial origin highlighted by POU2F3-positive thymic tuft cells and concomitant myoid cell proliferation. International-journal

    Akihiko Sugimoto, Yosuke Yamada, Masakazu Fujimoto, Sachiko Minamiguchi, Takuma Sato, Shusuke Akamatsu, Alexander Marx, Hironori Haga

    Virchows Archiv : an international journal of pathology　479　(1)　215-220　2021/05/24

    DOI： 10.1007/s00428-021-03125-2 　

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    Multilocular thymic cyst (MTC) and germ cell tumors are common diseases that impact the mediastinum. Correctly diagnosing these diseases can be difficult because several other conditions can mimic them. We report a male patient with MTC associated with mediastinal seminoma. A needle biopsy of the mediastinal tumor revealed numerous epithelioid cell granulomas that mimicked sarcoidosis or mycobacterial infection. However, large atypical cells positive for Oct3/4 and KIT were noted between the granulomas; thus, we diagnosed the patient with mediastinal seminoma. The resected tumor, after chemotherapy, consisted of multiple cystic lesions, and a residual germ cell tumor was first considered. However, thymic medulla-specific elements, namely, POU2F3-positive thymic tuft cells and rhabdomyomatous myoid cells accompanying the epithelium, led to the correct diagnosis of MTC. Our case underscores the importance of recognizing the histological features associated with mediastinal seminoma and provides novel findings for MTC pathogenesis, namely, the presence of thymic tuft cells.

  39. BK Virus-Associated Urothelial Carcinoma in a Patient with Peripheral Blood Stem Cell Transplantation for Acute Lymphoblastic Leukemia: A Case Report

    Juntaro Koyama, Yoshihide Kawasaki, Shingo Kimura, Takuma Sato, Shuichi Shimada, Naoki Kawamorita, Shinichi Yamashita, Ryo Nakagawa, Akihisa Kawajiri, Koichi Onodera, Yasushi Onishi, Koji Mitsuzuka, Mika Watanabe, Akihiro Ito

    Case Reports in Oncology　8-12　2021/01/11

    Publisher: S. Karger AG

    DOI： 10.1159/000511053 　

    eISSN： 1662-6575

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    Bladder tamponade due to hemorrhagic cystitis caused by BK virus in immunocompetent patients is familiar to urologists. BK virus is an important cause of nephropathy and graft loss in kidney transplant recipients. Although urothelial carcinoma of the bladder in kidney transplant recipients with persistent BK viruria is known, BK virus-associated urothelial carcinoma (BKVUC) in peripheral blood stem cell transplantation recipients is not as well known. A 54-year-old man with acute lymphoblastic leukemia was treated in the Department of Hematology of our hospital. After recurrence 25 months later, he received chemotherapy for half a year and underwent peripheral blood stem cell transplantation. He achieved temporarily complete remission, but he developed hematuria with BK virus-positive result 1 month after peripheral blood stem cell transplantation. One month later, he developed bladder tamponade-diagnosed hemorrhagic cystitis due to BK virus in our Urological Department. We performed transurethral coagulation to manage hemorrhage and removed a bleeding lesion in the bladder wall. Pathological examination of the removed bladder wall revealed pT1 stage BKVUC. We found that bladder tamponade could have led to reactivation of BK virus in this immunocompetent patient. This could be the first report of BKVUC of the bladder found in a peripheral blood stem cell transplantation recipient with close urological follow-up for 24 months. Adequate removal of bleeding lesions from the bladder mucosa with appropriate timing during hemorrhagic cystitis due to BKVUC could be essential to achieve good outcomes.

  40. Combination Therapy of Pembrolizumab plus Axitinib for a Patient on Hemodialysis with Metastatic Renal Cell Carcinoma: A Case Report

    Yuki Katsumata, Yoshihide Kawasaki, Kayu Tanaka, Daisuke Nakayama, Hiromichi Katayama, Shuichi Shimada, Yohei Satake, Takuma Sato, Naoki Kawamorita, Shinichi Yamashita, Testuya Sato, Kosuke Shoji, Koji Mitsuzuka, Akihiro Ito

    CASE REPORTS IN ONCOLOGY　14　(3)　1522-1529　2021

    DOI： 10.1159/000519855 　

    ISSN： 1662-6575

  41. Night-Time Urinary Frequency Is Increased after the Great East Japan Earthquake along with Seasonal Variation: A Five-Year Longitudinal Study in Kesennuma City.

    Shingo Kimura, Takuma Sato, Kazuhiko Orikasa, Haruo Nakagawa, Akihiro Ito

    The Tohoku journal of experimental medicine　252　(4)　329-337　2020/12

    DOI： 10.1620/tjem.252.329 　

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    Disasters influence various health conditions; however, little has been reported about urinary symptoms. The objective of this study is to evaluate whether night-time urinary frequency was influenced by the Great East Japan Earthquake (GEJE) in March 2011. We also evaluated seasonal variation of night-time frequency, which may affect the primary objective. A retrospective chart review was conducted on 300 evaluable patients who resided in the impacted area: 263 men with benign prostatic hyperplasia and/or overactive bladder and 37 women with overactive bladder. Data concerning night-time frequency were collected repeatedly every three months from March 2009 until March 2014, then compared yearly and seasonally among same patients. In addition, night-time frequency was analyzed for potential relations to sex, age, comorbidities, and whether residences had been destroyed. There was a significant increase of night-time frequency during 2011-2013 when compared yearly with 2009 and 2010. In seasonal comparisons of the entire period, night-time frequency was greater during autumn and winter compared with summer. In quarterly comparisons, a sudden increase was not observed after the GEJE, but night-time frequency was increased significantly in spring, summer and autumn in 2011 when compared with the corresponding seasons in 2010. While hypertension was related to exacerbation of night-time frequency during winter, we did not find any factors associated with increase after the disaster out of sex, age, comorbidities or residential situations. In conclusion, night-time urinary frequency is increased shortly after the GEJE and remains elevated for the following three years along with seasonal variation.

  42. Impact of cancer therapy on post-treatment ejaculation disorder and sexual life in testicular cancer survivors. International-journal

    Juntaro Koyama, Shinichi Yamashita, Shigeyuki Yamada, Shinji Fujii, Takuro Goto, Hiromichi Katayama, Yohei Satake, Takuma Sato, Shuichi Shimada, Yoshihide Kawasaki, Naoki Kawamorita, Koji Mitsuzuka, Yoichi Arai, Akihiro Ito

    International journal of urology : official journal of the Japanese Urological Association　28　(1)　69-74　2020/10/31

    DOI： 10.1111/iju.14403 　

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    OBJECTIVE: To evaluate the impact of cancer therapy on post-treatment ejaculation in patients with testicular cancer. METHODS: A total of 74 testicular cancer survivors provided completed International Index of Erectile Function-15 questionnaires before and after treatment between 2010 and 2017. Sexual function, particularly ejaculatory function, was evaluated before and after treatment. In this study, patients who answered "1 = almost never/never" or "2 = a few times" for questionnaire number 9 (ejaculation frequency) were defined as having "ejaculation disorder." RESULTS: Of 74 testicular cancer survivors, 50 (68%) had no ejaculation disorders before treatment. Four (44%) of nine survivors, who received chemotherapy and retroperitoneal lymph node dissection, developed ejaculation disorders after treatment. On multivariate analysis, retroperitoneal lymph node dissection was a significant predictor of post-treatment ejaculation disorder (P = 0.042). Of 60 survivors with evaluable ejaculation function after treatment, 24 (40%) did not attempt sexual intercourse, and multivariate analysis showed ejaculation disorder had a significant negative impact on having sexual intercourse (P = 0.035). Furthermore, the mean International Index of Erectile Function-15 scores in the groups with and without ejaculation disorders after treatment were 24.0 and 51.9, respectively (P < 0.001). CONCLUSION: Ejaculation disorders occur at high rate after retroperitoneal lymph node dissection. Many testicular cancer survivors reporting no sexual intercourse have ejaculation disorders, suggesting an adverse impact on sexual life. Urologists should provide proper counselling regarding the risk of ejaculation disorder and its possible impact on sexual life.

  43. Improvement of Cardiac Function by Laparoscopic Adrenalectomy in a Patient with Severe Heart Failure Attributable to Primary Aldosteronism. Peer-reviewed

    Shin Sato, Yoshihide Kawasaki, Akihiro Ito, Ryo Morimoto, Shuichi Shimada, Takuma Sato, Hideaki Izumi, Naoki Kawamorita, Shinichi Yamashita, Koji Mitsuzuka, Yoichi Arai

    The Tohoku journal of experimental medicine　248　(1)　31-36　2019/05

    DOI： 10.1620/tjem.248.31 　

    ISSN： 0040-8727

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    Aldosterone affects various systems and organs, including the cardiovascular system, through mineralocorticoid receptors. We here report a primary aldosteronism patient with severe cardiac dysfunction who showed dramatic improvement after laparoscopic adrenalectomy. The 57-year-old man presented with acute heart failure exacerbation. Performance status was 4, and New York Heart Association classification was 4. Echocardiography showed diffuse hypokinetic wall motion with an ejection fraction of 20%. The patient was found to have a high plasma level of brain natriuretic peptide (4,935 pg/mL), hypokalemia (2.7 mEq/L), an extremely elevated plasma aldosterone concentration (1,804 pg/mL), and high aldosterone-to-renin ratio [plasma aldosterone concentration (pg/mL)/plasma renin activity (ng/mL/hr)] (9,002). Computed tomography revealed a tumor 42 mm in diameter in the right adrenal gland. Primary aldosteronism was diagnosed with adrenal venous sampling. Medical treatment for heart failure was continued for several months, but the cardiac function was not sufficiently improved, suggesting the indication of heart transplantation. However, the patient could not be considered a candidate because of the adrenal tumor. Laparoscopic adrenalectomy was therefore performed. Immediately after surgery, echocardiography showed improved wall motion with an ejection fraction of 36%. Performance status and New York Heart Association classification were improved to 0 and 2, respectively. The present case has shown the efficacy of laparoscopic adrenalectomy for primary aldosteronism patients with severe heart failure.

  44. Phosphodiesterase type 5 inhibitor attenuates chronic ischemia-induced prostatic hyperplasia in a rat model. International-journal Peer-reviewed

    Shinji Fujii, Shinichi Yamashita, Natsuho Hayashi, Takuro Goto, Juntaro Koyama, Takuma Sato, Shuichi Shimada, Yoshihide Kawasaki, Hideaki Izumi, Naoki Kawamorita, Koji Mitsuzuka, Akihiro Ito, Yoichi Arai

    The Prostate　79　(5)　536-543　2019/04

    DOI： 10.1002/pros.23759 　

    ISSN： 0270-4137

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    BACKGROUND: Many elderly men suffer from benign prostatic hyperplasia (BPH). Recently, chronic ischemia in the prostate has been suggested to be related to BPH. Thus, the impact of chronic ischemia on the development of prostatic hyperplasia and the efficacy of phosphodiesterase type 5 (PDE5) inhibitor for hyperplasia were evaluated in a rat model with chronic ischemia induced by local atherosclerosis. METHODS: Eighteen male Sprague-Dawley rats were divided into three groups: sham operation, regular diet, placebo (SRP); arterial endothelial injury, high cholesterol diet, placebo (AHP); or arterial endothelial injury, high cholesterol diet, and tadalafil as a PDE5 inhibitor (AHT). The endothelial injury in the common iliac arteries was performed using a 2-Fr Fogarty arterial embolectomy catheter through an incision in the femoral artery into the common iliac artery. Diet and oral drugs were administrated for 8 weeks after surgery. At 8 weeks, blood flow to the ventral prostate (VP) was measured using laser speckle blood flow analysis, and the VP was histologically evaluated. RESULTS: In the AHP group, prostatic blood flow was reduced, and mean VP weight and the interstitial area were significantly enlarged compared with the SRP group. In the AHT group, tadalafil administration obviously ameliorated the reduction of prostatic blood flow relative to the AHP group. Importantly, mean VP weight and the morphological changes in the AHT group were significantly smaller than those in the AHP group. CONCLUSIONS: Enlargement of the VP resulted from chronic ischemia induced by local arteriosclerosis. Also, administration of tadalafil attenuated VP enlargement. Chronic ischemia in the prostate might thus contribute to the development of BPH, and PDE5 inhibitors might provide an innovative approach to preventing BPH.

  45. Monitoring of Blood Vessel Density Using Contrast-Enhanced High Frequency Ultrasound May Facilitate Early Diagnosis of Lymph Node Metastasis Peer-reviewed

    Takuma Sato, Tomoaki Takemura, Tomoki Ouchi, Shiro Mori, Maya Sakamoto, Yoichi Arai, Tetsuya Kodama

    JOURNAL OF CANCER　8　(5)　704-715　2017

    DOI： 10.7150/jca.18027 　

    ISSN： 1837-9664

  46. Direct Delivery of a Cytotoxic Anticancer Agent into the Metastatic Lymph Node Using Nano/Microbubbles and Ultrasound Peer-reviewed

    Takuma Sato, Shiro Mori, Maya Sakamoto, Yoichi Arai, Tetsuya Kodama

    PLOS ONE　10　(4)　e0123619　2015/04

    DOI： 10.1371/journal.pone.0123619 　

    ISSN： 1932-6203

  47. 転移リンパ節に対する超音波と微小気泡を利用したリンパ行性薬剤送達法の開発

    白井 優子, 加藤 茂樹, 佐藤 琢磨, 森 士朗, 小玉 哲也

    日本DDS学会学術集会プログラム予稿集　30回　155-155　2014/07

    Publisher: 日本DDS学会

  48. THE COMBINATION OF INTRALYMPHATIC CHEMOTHERAPY WITH ULTRASOUND AND NANO-/MICROBUBBLES IS EFFICIENT IN THE TREATMENT OF EXPERIMENTAL TUMORS IN MOUSE LYMPH NODES Peer-reviewed

    Takuma Sato, Shiro Mori, Yoichi Arai, Tetsuya Kodama

    ULTRASOUND IN MEDICINE AND BIOLOGY　40　(6)　1237-1249　2014/06

    DOI： 10.1016/j.ultrasmedbio.2013.12.012 　

    ISSN： 0301-5629

    eISSN： 1879-291X

  49. Lymphatic mapping of mice with systemic lymphoproliferative disorder: Usefulness as an inter-lymph node metastasis model of cancer Peer-reviewed

    Lenan Shao, Shiro Mori, Yoko Yagishita, Tatsuki Okuno, Yuriko Hatakeyama, Takuma Sato, Tetsuya Kodama

    JOURNAL OF IMMUNOLOGICAL METHODS　389　(1-2)　69-78　2013/03

    DOI： 10.1016/j.jim.2013.01.004 　

    ISSN： 0022-1759

  50. [Radical retropubic prostatectomy]. Peer-reviewed

    Arai Y, Kaiho Y, Sato T, Kawamorita N, Ishidoya S

    Nihon rinsho. Japanese journal of clinical medicine　69 Suppl 5　334-338　2011/06

    ISSN： 0047-1852

  51. Metastatic renal cell carcinoma to right ventricle without vena caval involvement Peer-reviewed

    Takuma Sato, Atsushi Takeda, Shigeyuki Yamada, Isao Numata, Kazuhiro Sakamoto

    INTERNATIONAL JOURNAL OF UROLOGY　15　(4)　366-368　2008/04

    DOI： 10.1111/j.1442-2042.2008.01996.x 　

    ISSN： 0919-8172

  52. Intrarenal pseudoaneurysm with renal cell carcinoma Peer-reviewed

    Takuma Sato, Atsushi Takeda, Shigeynki Yamada, Isao Numata

    JOURNAL OF MEDICAL ULTRASONICS　35　(1)　31-32　2008

    DOI： 10.1007/s10396-007-0162-y 　

    ISSN： 1346-4523

Show all ︎Show first 5

Misc. 148

  1. 治療に難渋した転移性神経内分泌前立腺癌症例

    桐原大地, 佐藤友紀, 西條憲, 増田博, 加藤淳史, 佐竹洋平, 佐藤琢磨, 川崎芳英, 川守田直樹, 山下慎一, 伊藤明宏

    泌尿器外科　38　(2)　2025

    ISSN： 0914-6180

  2. 術後補助免疫療法中に早期再発をきたした遺伝性平滑筋腫症腎細胞癌症候群の一例

    増田博, 佐藤友紀, 佐藤聡子, 林柚花, 坂上里絵, 佐藤琢磨, 川崎芳英, 川守田直樹, 山下慎一, 伊藤明宏

    泌尿器外科　38　(2)　2025

    ISSN： 0914-6180

  3. 副腎皮質髄質混合腫瘍の1例

    北村洋輝, 佐藤琢磨, 三浦竜也, 渡辺真秀, 佐藤友紀, 川崎芳英, 川守田直樹, 山下慎一, 小野美澄, 片桐秀樹, 佐藤聡子, 伊藤明宏

    泌尿器外科　38　(2)　2025

    ISSN： 0914-6180

  4. 剖検にて判明した進行腎癌に対する免疫チェックポイント阻害薬関連劇症型心筋炎の1例

    林柚花, 川崎芳英, 松井涼, 坂上理絵, 後藤拓郎, 方山博路, 佐藤琢磨, 川守田直樹, 山下慎一, 佐藤聡子, 伊藤明宏

    泌尿器外科　38　(2)　2025

    ISSN： 0914-6180

  5. 原発性アルドステロン症治療の衆知を集める(最適な治療の解は?) 腹腔鏡下副腎摘除術が原発性アルドステロン症患者のQOL、心機能に与える影響

    川崎 芳英, 祢津 晋久, 手塚 ゆうた, 小野 美澄, 尾股 慧, 小黒 草太, 方山 博路, 佐竹 洋平, 佐藤 琢磨, 川守田 直樹, 山下 慎一, 高瀬 圭, 佐藤 文俊, 片桐 秀樹, 伊藤 明宏

    日本内分泌外科学会雑誌　41　(Suppl.1)　S136-S136　2024/04

    Publisher: (一社)日本内分泌外科学会

    ISSN： 2434-6535

    eISSN： 2758-8785

  6. ロボット支援下副腎手術の衆知を集める(標準化を目指して) 原発性アルドステロン症に対するロボット支援下副腎部分切除術

    川崎 芳英, 手塚 雄太, 小野 美澄, 尾股 慧, 佐藤 友紀, 方山 博路, 佐竹 洋平, 佐藤 琢磨, 川守田 直樹, 山下 慎一, 小黒 草太, 高瀬 圭, 片桐 秀樹, 伊藤 明宏

    日本内分泌外科学会雑誌　41　(Suppl.1)　S152-S152　2024/04

    Publisher: (一社)日本内分泌外科学会

    ISSN： 2434-6535

    eISSN： 2758-8785

  7. 進行腎癌患者に対する当院の1次療法の選択と予後への影響

    赤井太郎, 川崎芳英, 佐藤友紀, 方山博路, 佐竹洋平, 佐藤琢磨, 川守田直樹, 山下慎一, 伊藤明宏

    日本泌尿器科学会東部総会プログラム・抄録集　89th (CD-ROM)　2024

  8. 副腎皮質癌の病態と治療戦略

    川崎芳英, 手塚雄太, 高橋紀善, 佐藤友紀, 方山博路, 佐藤琢磨, 小野美澄, 小野美澄, 川守田直樹, 川守田直樹, 山下慎一, 神宮啓一, 片桐秀樹, 伊藤明宏

    日本泌尿器科学会東部総会プログラム・抄録集　89th (CD-ROM)　2024

  9. 転移を有する遺伝性平滑筋腫症腎細胞癌症候群2例の治療経過と遺伝子プロファイリング

    佐藤友紀, 増田博, 佐藤聡子, 方山博路, 佐竹洋平, 佐藤琢磨, 川崎芳英, 川守田直樹, 山下慎一, 城田英和, 伊藤明宏

    日本泌尿器科学会東部総会プログラム・抄録集　89th (CD-ROM)　2024

  10. 術前化学放射線治療併用進行直腸癌に対する尿路再建を伴うロボット支援下手術の実際

    佐藤友紀, 川守田直樹, 唐澤秀明, 方山博路, 佐竹洋平, 佐藤琢磨, 川崎芳英, 山下慎一, 大沼忍, 伊藤明宏

    日本泌尿器内視鏡・ロボティクス学会(Web)　38th　2024

  11. 後腹膜アプローチで行ったロボット支援腎尿管全摘術の検討

    川守田直樹, 後藤拓郎, 佐藤友紀, 方山博路, 佐竹洋平, 佐藤琢磨, 川崎芳英, 山下慎一, 伊藤明宏

    日本泌尿器内視鏡・ロボティクス学会(Web)　38th　2024

  12. PhiとS2,3PSA%の監視療法におけるプロトコール生検の再分類予測の検討:PRIAS-JAPAN

    加藤琢磨, 米山徹, 畠山真悟, 佐藤琢磨, 松本隆児, 森啓一郎, 谷川俊貴, 坂本信一, 井上雅晴, 土肥洋一郎, 福原浩, 納谷幸男, 大山力, 杉元幹史

    日本癌治療学会学術集会(Web)　62nd　2024

  13. 東北大学病院における非セミノーマ性胚細胞腫瘍に対する腹腔鏡下後腹膜リンパ節郭清のアウトカム

    鈴木悠, 山下慎一, 後藤拓郎, 佐藤友紀, 方山博路, 佐竹洋平, 佐藤琢磨, 川崎芳英, 川守田直樹, 伊藤明宏

    泌尿器科再建再生研究会プログラム・抄録集　21st　2024

  14. 腎部分切除術(RAPN)の適応を再考する 開腹および腹腔鏡下腎部分切除との比較からみる、ロボット腎部分切除術の現状と今後

    川崎 芳英, 川守田 直樹, 木村 信吾, 佐藤 友紀, 方山 博路, 佐竹 洋平, 佐藤 琢磨, 高橋 紀善, 山下 慎一, 伊藤 明宏

    日本泌尿器内視鏡・ロボティクス学会総会　37回　SY3-5　2023/11

    Publisher: (一社)日本泌尿器内視鏡・ロボティクス学会

  15. ロボット支援腹腔鏡下全尿路全摘の2例

    方山 博路, 山下 麻衣子, 坂井 孝成, 佐竹 洋平, 嶋田 修一, 佐藤 琢磨, 川崎 芳英, 川守田 直樹, 山下 慎一, 伊藤 明宏

    日本泌尿器内視鏡・ロボティクス学会総会　37回　O-1　2023/11

    Publisher: (一社)日本泌尿器内視鏡・ロボティクス学会

  16. 監視療法の多施設共同前向き観察研究の長期成績 PRIAS-JAPAN

    加藤 琢磨, 松本 隆児, 横溝 晃, 土肥 洋一郎, 木村 高広, 久米 春喜, 福原 浩, 佐藤 琢磨, 猪口 淳一, 橋根 勝義, 坂本 真一, 杉元 幹史, 筧 善行

    日本癌治療学会学術集会抄録集　61回　O14-6　2023/10

    Publisher: (一社)日本癌治療学会

  17. 診断に難渋した筋層非浸潤性膀胱癌の晩期遠隔再発の一例

    渡辺 真秀, 川守田 直樹, 白岩 徹郎, 佐藤 友紀, 佐藤 琢磨, 川崎 芳英, 山下 慎一, 江幡 明子, 佐藤 聡子, 伊藤 明宏

    泌尿器外科　36　(10)　1158-1158　2023/10

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  18. 監視療法の多施設共同前向き観察研究の長期成績 PRIAS-JAPAN

    加藤 琢磨, 松本 隆児, 横溝 晃, 土肥 洋一郎, 木村 高広, 久米 春喜, 福原 浩, 佐藤 琢磨, 猪口 淳一, 橋根 勝義, 坂本 真一, 杉元 幹史, 筧 善行

    日本癌治療学会学術集会抄録集　61回　O14-6　2023/10

    Publisher: (一社)日本癌治療学会

  19. 尿路上皮癌に対するPembrolizumabの治療効果予測因子の後ろ向き研究-観察期間3年の結果(Predictive factors in patients with metastatic urothelial carcinoma treated with pembrolizumab: 36 month follow-up study in Japanese patients)

    勝又 有記, 嶋田 修一, 方山 博路, 佐竹 洋平, 佐藤 琢磨, 川崎 芳英, 川守田 直樹, 山下 慎一, 伊藤 明宏

    日本泌尿器科学会総会　110回　PP19-01　2023/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  20. ロボット支援前立腺全摘術後早期の排尿機能に関するQOL研究 EPICを用いた検討(Patient-reported outcome of urinary function and bother from shortly after robot-assisted radical prostatectomy)

    川守田 直樹, 石塚 雄一, 木村 信吾, 田中 峻希, 方山 博路, 佐竹 洋平, 佐藤 琢磨, 嶋田 修一, 川崎 芳英, 山下 慎一, 三塚 浩二, 伊藤 明宏

    日本泌尿器科学会総会　110回　PP41-02　2023/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  21. 下大静脈腫瘍塞栓を伴う腎癌において、術前CTの腫瘍早期濃染効果の低下は、術中肺腫瘍塞栓の予測因子となるかの検討(Can Preoperative CT findings predict the risk of intraoperative pulmonary tumor embolization in patients with renal cell carcinoma extending into IVC?)

    方山 博路, 佐藤 琢磨, 嶋田 修一, 川崎 芳英, 川守田 直樹, 山下 慎一, 佐藤 友美, 小黒 草太, 佐藤 英揮, 佐藤 聡子, 赤松 大二郎, 伊藤 明宏

    日本泌尿器科学会総会　110回　PP55-09　2023/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  22. マウス膀胱がんモデルに対する、微小気泡と超音波を併用した抗がん剤の膀胱注入療法の治療効果の解析(The combination of vesical instillation of chemotherapy with ultrasound and nanobubbles is efficient against experimental tumors in murine bladder cancer model)

    鈴木 健大, 佐藤 琢磨, アリウンブヤン・スフバートル, 阪本 真弥, 森 士朗, 小玉 哲也, 伊藤 明宏

    日本泌尿器科学会総会　110回　AOP06-08　2023/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  23. 筋層非浸潤性膀胱がんに対する術後膀胱内注入療法および2nd TURの治療効果について(Recurrence-free survival in patients with non-muscle invasive bladder cancer who received adjuvant intravesical therapy and second transurethral resection)

    佐藤 琢磨, 田中 峻希, 折笠 一彦, 齋藤 英郎, 池田 義弘, 徳山 聡, 喜屋武 淳, 川村 貞文, 太田 章三, 小林 恭, 小川 修, 伊藤 明宏

    日本泌尿器科学会総会　110回　OP41-05　2023/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  24. 東北大学病院における進行腎細胞癌に対する1次療法の選択に関する検討(Selection of first-line therapy for advanced renal cell carcinoma at Tohoku University Hospital)

    坂井 孝成, 川崎 芳英, 諸角 謙人, 方山 博路, 嶋田 修一, 佐藤 琢磨, 佐竹 洋平, 川守田 直樹, 山下 慎一, 伊藤 明宏

    日本泌尿器科学会総会　110回　OP63-01　2023/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  25. 尿路上皮癌に対するPembrolizumabの治療効果予測因子の後ろ向き研究-観察期間3年の結果(Predictive factors in patients with metastatic urothelial carcinoma treated with pembrolizumab: 36 month follow-up study in Japanese patients)

    勝又 有記, 嶋田 修一, 方山 博路, 佐竹 洋平, 佐藤 琢磨, 川崎 芳英, 川守田 直樹, 山下 慎一, 伊藤 明宏

    日本泌尿器科学会総会　110回　PP19-01　2023/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  26. ロボット支援前立腺全摘術後早期の排尿機能に関するQOL研究 EPICを用いた検討(Patient-reported outcome of urinary function and bother from shortly after robot-assisted radical prostatectomy)

    川守田 直樹, 石塚 雄一, 木村 信吾, 田中 峻希, 方山 博路, 佐竹 洋平, 佐藤 琢磨, 嶋田 修一, 川崎 芳英, 山下 慎一, 三塚 浩二, 伊藤 明宏

    日本泌尿器科学会総会　110回　PP41-02　2023/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  27. 下大静脈腫瘍塞栓を伴う腎癌において、術前CTの腫瘍早期濃染効果の低下は、術中肺腫瘍塞栓の予測因子となるかの検討(Can Preoperative CT findings predict the risk of intraoperative pulmonary tumor embolization in patients with renal cell carcinoma extending into IVC?)

    方山 博路, 佐藤 琢磨, 嶋田 修一, 川崎 芳英, 川守田 直樹, 山下 慎一, 佐藤 友美, 小黒 草太, 佐藤 英揮, 佐藤 聡子, 赤松 大二郎, 伊藤 明宏

    日本泌尿器科学会総会　110回　PP55-09　2023/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  28. Considerations for safe laparoscopic renal biopsy

    川崎芳英, 森本玲, 手塚雄太, 尾股慧, 小野美澄, 山崎有人, 方山博路, 佐竹洋平, 嶋田修一, 佐藤琢磨, 川守田直樹, 山下慎一, 宮崎真理子, 田中哲洋, 鈴木貴, 佐藤文俊, 笹野公伸, 伊藤明宏

    Japanese Journal of Endourology and Robotics (Web)　36　(1)　124-128　2023/04

    Publisher: (一社)日本泌尿器内視鏡・ロボティクス学会

    ISSN： 2436-875X

    eISSN： 2436-875X

  29. ロボット支援腹腔鏡下全尿路全摘の2例

    方山博路, 山下麻衣子, 坂井孝成, 佐竹洋平, 嶋田修一, 佐藤琢磨, 川崎芳英, 川守田直樹, 山下慎一, 伊藤明宏

    日本泌尿器内視鏡・ロボティクス学会(Web)　37th　O-1　2023

    Publisher: (一社)日本泌尿器内視鏡・ロボティクス学会

  30. 開腹および腹腔鏡下腎部分切除との比較からみる,ロボット腎部分切除術の現状と今後

    川崎芳英, 川守田直樹, 木村信吾, 佐藤友紀, 方山博路, 佐竹洋平, 佐藤琢磨, 高橋紀善, 山下慎一, 伊藤明宏

    日本泌尿器内視鏡・ロボティクス学会(Web)　37th　SY3-5　2023

    Publisher: (一社)日本泌尿器内視鏡・ロボティクス学会

  31. 前立腺生検により組織所見を確認し得たIgG4関連下垂体炎の一例

    玉懸 直人, 手塚 雄太, 尾股 慧, 小野 美澄, 森本 玲, 佐藤 琢磨, 伊藤 明宏, 山崎 有人, 鈴木 貴, 田中 哲洋, 佐藤 文俊

    日本内分泌学会雑誌　98　(2)　569-569　2022/10

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  32. 逐次治療後にdeferred cytoreductive nephrectomyにてsurgical CRを得た進行腎細胞癌の一例

    中川 拓也, 川崎 芳英, 佐竹 洋平, 片山 博路, 嶋田 修一, 佐藤 琢磨, 川守田 直樹, 山下 慎一, 三塚 浩二, 伊藤 明宏, 佐藤 聡子, 神山 篤史, 石田 晶玄, 大塚 英郎

    泌尿器外科　35　(9)　1021-1021　2022/09

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  33. 逐次治療後にdeferred cytoreductive nephrectomyにてsurgical CRを得た進行腎細胞癌の一例

    中川 拓也, 川崎 芳英, 佐竹 洋平, 片山 博路, 嶋田 修一, 佐藤 琢磨, 川守田 直樹, 山下 慎一, 三塚 浩二, 伊藤 明宏, 佐藤 聡子, 神山 篤史, 石田 晶玄, 大塚 英郎

    泌尿器外科　35　(9)　1021-1021　2022/09

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  34. 転移性腎癌に対してペンブロリズマブ・アキシチニブ併用療法を施行した血液透析患者の一例

    勝又 有記, 川崎 芳英, 方山 博路, 佐竹 洋平, 佐藤 琢磨, 嶋田 修一, 川守田 直樹, 山下 慎一, 三塚 浩二, 伊藤 明宏

    泌尿器外科　35　(臨増)　816-816　2022/07

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  35. DIAGNOSTIC ACCURACY OF TRANSPERINEAL MRI-ULTRASOUND FUSION BIOPSY AT THE INTRODUCTION PERIOD

    服部悠斗, 河野仁, 吉野喬之, 吉野喬之, 増井仁彦, 佐藤琢磨, 佐藤琢磨, 嘉島相輝, 嘉島相輝, 佐野剛視, 後藤崇之, 澤田篤郎, 赤松秀輔, 小林恭, 井上貴博, 井上貴博, 小川修

    泌尿器科紀要　68　(4)　99-105　2022/04

    Publisher: 泌尿器科紀要刊行会

    ISSN： 0018-1994

  36. 中/高リスク筋層非浸潤性膀胱がんに対するBCG膀胱内注入療法の治療効果について

    佐藤 琢磨, 小林 恭, 田中 峻希, 折笠 一彦, 齋藤 英郎, 池田 義弘, 徳山 聡, 喜屋武 淳, 川村 貞文, 太田 章三, 小川 修, 伊藤 明宏

    日本泌尿器科学会総会　109回　PP06-01　2021/12

    Publisher: (一社)日本泌尿器科学会総会事務局

  37. 当院でのロボット支援下根治的前立腺全摘除術におけるリンパ節郭清の適応基準と郭清範囲の検討

    畑野 翔太郎, 後藤 崇之, 木村 博子, 河野 仁, 増井 仁彦, 佐藤 琢磨, 佐野 剛視, 澤田 篤郎, 赤松 秀輔, 小林 恭, 井上 貴博, 小川 修

    日本泌尿器科学会総会　109回　PP41-04　2021/12

    Publisher: (一社)日本泌尿器科学会総会事務局

  38. 腎移植後の固有腎に発生した尿路上皮癌の一例

    荒川 洋介, 佐藤 琢磨, 嶋田 修一, 川崎 芳英, 川守田 直樹, 山下 慎一, 三塚 浩二, 伊藤 明宏

    泌尿器外科　34　(11)　1288-1288　2021/11

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  39. 水腎症解除にて腎機能廃絶を回避できなかった後腹膜線維症の1例

    赤井 太郎, 川崎 芳英, 坂上 里絵, 木村 信吾, 佐藤 琢磨, 嶋田 修一, 泉 秀明, 山下 慎一, 三塚 浩二, 伊藤 明宏

    泌尿器外科　34　(11)　1292-1292　2021/11

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  40. 急速増大した肺転移Growing teratoma syndromeの精巣腫瘍を救命し得たダウン症患者の一例

    山田 智哉, 方山 博路, 長澤 美幸, 諸角 謙人, 佐藤 琢磨, 嶋田 修一, 川崎 芳英, 川守田 直樹, 山下 慎一, 三塚 浩二, 伊藤 明宏

    泌尿器外科　34　(11)　1296-1296　2021/11

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  41. 腎嚢胞に発生した神経内分泌腫瘍の一例

    井上 拓也, 嶋田 修一, 佐藤 琢磨, 川崎 芳英, 川守田 直樹, 山下 慎一, 三塚 浩二, 伊藤 明宏, 藤島 史喜

    泌尿器外科　34　(11)　1298-1298　2021/11

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  42. 副腎鏡視下手術 ここまでの症例に応用(経験に基づいた限界と展望) 褐色細胞腫及び傍神経節腫に対する腹腔鏡手術における到達法の選択について(経験に基づいた限界と展望)

    川崎 芳英, 川守田 直樹, 森本 玲, 小野 美澄, 尾股 慧, 手塚 雄太, 方山 博路, 佐竹 洋平, 佐藤 琢磨, 嶋田 修一, 山下 慎一, 三塚 浩二, 伊藤 明宏

    日本内分泌外科学会雑誌　38　(Suppl.2)　S247-S247　2021/10

    Publisher: (一社)日本内分泌外科学会

    ISSN： 2434-6535

    eISSN： 2758-8785

  43. 不完全な表現型のBirt-Hogg-Dube症候群を呈するFolliculin遺伝子の新規ミスセンス変異

    佐野 剛視, 福井 智洋, 牧田 哲幸, 清水 浩介, 河野 仁, 増井 仁彦, 佐藤 琢磨, 後藤 崇之, 澤田 篤郎, 赤松 秀輔, 小林 恭, 鳥嶋 雅子, 和田 敬仁, 古屋 充子, 小川 修

    日本癌治療学会学術集会抄録集　59回　O17-6　2021/10

    Publisher: (一社)日本癌治療学会

  44. 透析腎癌患者における治療モニタリングによるカボザンチニブ血清濃度の検討

    川崎 芳英, 高崎 新也, 前川 正充, 嶋田 修一, 佐竹 洋平, 方山 博路, 佐藤 琢磨, 川守田 直樹, 山下 慎一, 三塚 浩二, 伊藤 明宏

    日本癌治療学会学術集会抄録集　59回　O23-4　2021/10

    Publisher: (一社)日本癌治療学会

  45. ロボット手術アップデート ロボット支援下前立腺全摘除術におけるアップデート 尿禁制の早期回復を目指して

    澤田 篤郎, 小林 恭, 高橋 雄大, 河野 仁, 増井 仁彦, 佐藤 琢磨, 佐野 剛視, 後藤 崇之, 赤松 秀輔, 小川 修

    泌尿器科紀要　67　(6)　289-289　2021/06

    Publisher: 泌尿器科紀要刊行会

    ISSN： 0018-1994

  46. 当院における新規ドナー特異的抗体(DSA)の検討

    中村健治, 小林恭, 河野仁, 増井仁彦, 佐藤琢磨, 佐野剛視, 後藤崇之, 澤田篤郎, 赤松秀輔, 小川修

    日本臨床腎移植学会プログラム・抄録集　54th　140-140　2021

    Publisher: (一社)日本臨床腎移植学会

  47. RARC ICUDを行う際のpit fall RARC ICUDを行うにあたっての当院での注意点

    澤田 篤郎, 後藤 崇之, 佐野 剛視, 河野 仁, 佐藤 琢磨, 増井 仁彦, 赤松 秀輔, 小林 恭, 小川 修

    日本泌尿器内視鏡学会総会　34回　SY-3　2020/11

    Publisher: (一社)日本泌尿器内視鏡・ロボティクス学会

  48. 尿中代謝物の組み合わせによる腎癌の診断および悪性度予測モデルの構築

    川崎 芳英, 佐藤 友紀, 嶋田 修一, 前川 正充, 高崎 新也, 佐藤 琢磨, 川守田 直樹, 山下 慎一, 三塚 浩二, 伊藤 明宏

    泌尿器外科　33　(臨増)　886-886　2020/06

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  49. New risk classification to predict survival after administration of pembrolizumab for urothelial cancer. Multicenter retrospective study

    嶋田修一, 三塚浩二, 山下慎一, 川守田直樹, 佐藤琢磨, 佐竹洋平, 諸角謙人, 川崎芳英, 方山博路, 伊藤明宏

    日本泌尿器科学会総会(Web)　108th　1844-1844　2020

    Publisher: (一社)日本泌尿器科学会総会事務局

  50. A risk assessment for intravesical recurrence in non-muscle invasive bladder cancer and outcome of intravesical BCG immunotherapy

    佐藤琢磨, 山下慎一, 齋藤英郎, 池田義弘, 喜屋武淳, 太田章三, 伊藤明宏

    日本泌尿器科学会総会(Web)　108th　1834-1834　2020

    Publisher: (一社)日本泌尿器科学会総会事務局

  51. Effect of treatment for testicular tumor on postoperative ejaculation function

    小山淳太朗, 山下慎一, 山田成幸, 山田成幸, 藤井紳司, 藤井紳司, 方山博路, 佐竹洋平, 佐藤琢磨, 嶋田修一, 川崎芳英, 川守田直樹, 三塚浩二, 荒井陽一, 荒井陽一, 伊藤明宏

    日本泌尿器科学会総会(Web)　108th　835-835　2020

    Publisher: (一社)日本泌尿器科学会総会事務局

  52. 精巣腫瘍サバイバーにおける性機能の横断的調査

    小山淳太朗, 山下慎一, 山田成幸, 山田成幸, 藤井紳司, 藤井紳司, 後藤拓郎, 佐藤琢磨, 嶋田修一, 川崎芳英, 泉秀明, 泉秀明, 川守田直樹, 三塚浩二, 荒井陽一, 荒井陽一, 伊藤明宏

    日本性機能学会雑誌　34　(2)　152-152　2019/08

    Publisher: (一社)日本性機能学会

    ISSN： 1345-8361

  53. 当院で経験した両側精巣腫瘍14例 対側発生時の病期に影響を与える因子の検討

    小山 淳太朗, 山下 慎一, 藤井 紳司, 山田 成幸, 佐藤 琢磨, 嶋田 修一, 川崎 芳英, 泉 秀明, 川守田 直樹, 三塚 浩二, 伊藤 明宏, 荒井 陽一

    日本泌尿器科学会総会　107回　AOP-035　2019/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  54. 多施設共同前向き研究からみた腎癌に対する腎摘除術後の腎機能に及ぼす因子の検討

    川崎 芳英, 伊藤 明宏, 嶋田 修一, 佐藤 琢磨, 泉 秀明, 川守田 直樹, 三塚 浩二, 齋藤 英郎, 荒井 陽一

    日本泌尿器科学会総会　107回　OP-044　2019/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  55. ホスホジエステラーゼ5型阻害剤はアテローム性動脈硬化による慢性骨盤内虚血ラットモデルに生じる前立腺肥大を抑制する

    藤井 紳司, 山下 慎一, 林 夏穂, 後藤 拓郎, 小山 淳太朗, 佐藤 琢磨, 嶋田 修一, 川崎 芳英, 泉 秀明, 川守田 直樹, 三塚 浩二, 伊藤 明宏, 荒井 陽一

    日本泌尿器科学会総会　107回　PP1-082　2019/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  56. 非セミノーマ精巣腫瘍に対する化学療法後の腹腔鏡下後腹膜リンパ節郭清術の長期治療成績

    山下 慎一, 藤井 紳司, 小山 淳太朗, 山田 成幸, 佐藤 琢磨, 嶋田 修一, 川崎 芳英, 泉 秀明, 川守田 直樹, 三塚 浩二, 伊藤 明宏, 荒井 陽一

    日本泌尿器科学会総会　107回　PP1-134　2019/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  57. 尿路上皮癌に対するペムブロリズマブの初期使用経験/効果を予測する臨床バイオマーカーの検討

    嶋田 修一, 三塚 浩二, 山下 慎一, 川守田 直樹, 泉 秀明, 佐藤 琢磨, 川崎 芳英, 伊藤 明宏

    日本泌尿器科学会総会　107回　PP3-276　2019/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  58. 当院における筋層非浸潤性膀胱がんの治療成績について

    佐藤 琢磨, 山下 慎一, 伊藤 明宏

    日本泌尿器科学会総会　107回　PP3-291　2019/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  59. 褐色細胞腫に対する腹腔鏡下副腎摘除術における到達法の検討(後腹膜到達法の有用性)

    川崎芳英, 諸角謙人, 嶋田修一, 佐藤琢磨, 方山博路, 川守田直樹, 山下慎一, 三塚浩二, 伊藤明宏

    日本泌尿器内視鏡学会(Web)　33rd　VWS-4　2019

    Publisher: (一社)日本泌尿器内視鏡・ロボティクス学会

  60. 当院におけるロボット支援腎部分切除術の治療成績-Da Vinci SとXiの比較-

    川守田直樹, 山下慎一, 三塚浩二, 川崎芳英, 嶋田修一, 佐藤琢磨, 伊藤明宏

    日本泌尿器内視鏡学会(Web)　33rd　O-1　2019

    Publisher: (一社)日本泌尿器内視鏡・ロボティクス学会

  61. 膀胱扁平上皮癌の一例

    今野 将人, 信濃 寛久, 佐藤 琢磨, 折笠 一彦

    泌尿器外科　32　(1)　84-85　2019/01

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  62. 腹腔鏡下副腎摘除術にて劇的な心機能の改善により心移植を回避できた重症心不全併発原発性アルドステロン症の一例

    佐藤 新, 川崎 芳英, 佐藤 真彦, 佐藤 琢磨, 川守田 直樹, 山下 真一, 三塚 浩二, 伊藤 明宏, 森本 玲, 伊藤 貞嘉, 荒井 陽一

    泌尿器外科　32　(1)　85-86　2019/01

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  63. 多発血管炎性肉芽腫症患者に発症した浸潤性膀胱癌の一例

    佐藤 真彦, 山下 慎一, 江里口 智大, 佐藤 琢磨, 川崎 芳英, 川守田 直樹, 荒井 陽一

    泌尿器外科　32　(1)　95-95　2019/01

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  64. ～エキスパートのResilienceを学ぶ～高難度の腹腔鏡下副腎摘除と後腹膜腫瘍摘除～困難例の克服とResilience～ 重症心不全併発原発性アルドステロン症に対する腹腔鏡下副腎摘除術

    川崎 芳英, 伊藤 明宏, 森本 玲, 嶋田 修一, 佐藤 琢磨, 泉 秀明, 川守田 直樹, 山下 慎一, 三塚 浩二, 荒井 陽一

    日本泌尿器内視鏡学会総会　32回　VWS-3　2018/11

    Publisher: (一社)日本泌尿器内視鏡・ロボティクス学会

  65. 当科における上部尿路結石手術の検討 高齢者、PS不良例を中心に

    小山 淳太朗, 泉 秀明, 佐藤 琢磨, 嶋田 修一, 川崎 芳英, 川守田 直樹, 山下 慎一, 三塚 浩二, 伊藤 明宏

    日本泌尿器内視鏡学会総会　32回　P-1　2018/11

    Publisher: (一社)日本泌尿器内視鏡・ロボティクス学会

  66. 胚細胞腫瘍予後不良において肺転移病変の最大径は予後不良因子である

    藤井 紳司, 山下 慎一, 山田 成幸, 佐藤 琢磨, 嶋田 修一, 泉 秀明, 川崎 芳英, 川守田 直樹, 三塚 浩二, 伊藤 明宏, 荒井 陽一

    泌尿器外科　31　(臨増)　845-845　2018/06

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  67. 陰茎悪性黒色腫の一例

    信濃 寛久, 今野 将人, 佐藤 琢磨, 折笠 一彦, 芳賀 貴裕

    泌尿器外科　31　(臨増)　820-820　2018/06

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  68. 胚細胞腫瘍予後不良において肺転移病変の最大径は予後不良因子である

    藤井 紳司, 山下 慎一, 山田 成幸, 佐藤 琢磨, 嶋田 修一, 泉 秀明, 川崎 芳英, 川守田 直樹, 三塚 浩二, 伊藤 明宏, 荒井 陽一

    泌尿器外科　31　(臨増)　845-845　2018/06

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  69. 東北大学病院における筋層非浸潤性膀胱がんの治療成績

    佐藤 琢磨, 荒井 陽一

    日本泌尿器科学会総会　106回　PP2-060　2018/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  70. EPIC、SF-8でみた低リスク前立腺癌短期〜中期QOL比較 PARP vs brachytherapy(BT) vs active surveillance(AS)

    嶋田 修一, 川崎 芳英, 伊藤 明宏, 三塚 浩二, 山下 慎一, 川守田 直樹, 泉 秀明, 佐藤 琢磨, 高橋 正博, 佐藤 友紀, 佐藤 真彦, 荒井 陽一

    日本泌尿器科学会総会　106回　PP2-066　2018/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  71. 東北大学病院における筋層非浸潤性膀胱がんの治療成績

    佐藤 琢磨, 荒井 陽一

    日本泌尿器科学会総会　106回　PP2-060　2018/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  72. EPIC、SF-8でみた低リスク前立腺癌短期〜中期QOL比較 PARP vs brachytherapy(BT) vs active surveillance(AS)

    嶋田 修一, 川崎 芳英, 伊藤 明宏, 三塚 浩二, 山下 慎一, 川守田 直樹, 泉 秀明, 佐藤 琢磨, 高橋 正博, 佐藤 友紀, 佐藤 真彦, 荒井 陽一

    日本泌尿器科学会総会　106回　PP2-066　2018/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  73. 重症心不全併発原発性アルドステロン症に対する腹腔鏡下副腎摘除術

    川崎芳英, 伊藤明宏, 森本玲, 嶋田修一, 佐藤琢磨, 泉秀明, 川守田直樹, 山下慎一, 三塚浩二, 荒井陽一

    Japanese Journal of Endourology　31　(3 (Web))　140 (WEB ONLY)-3　2018

    Publisher: (一社)日本泌尿器内視鏡・ロボティクス学会

    ISSN： 2186-1889

  74. 当科における上部尿路結石手術の検討:高齢者,PS不良例を中心に

    小山淳太朗, 泉秀明, 佐藤琢磨, 嶋田修一, 川崎芳英, 川守田直樹, 山下慎一, 三塚浩二, 伊藤明宏

    Japanese Journal of Endourology　31　(3 (Web))　919 (WEB ONLY)-1　2018

    Publisher: (一社)日本泌尿器内視鏡・ロボティクス学会

    ISSN： 2186-1889

  75. 下大静脈背側で増大する神経鞘腫に対し後腹膜アプローチ腹腔鏡下切除術を施行した2例

    後藤 拓郎, 山下 慎一, 嶋田 修一, 佐藤 琢磨, 川崎 芳英, 泉 秀明, 川守田 直樹, 三塚 浩二, 伊藤 明宏, 荒井 陽一

    Japanese Journal of Endourology　30　(3)　204-204　2017/11

    Publisher: (一社)日本泌尿器内視鏡学会

    ISSN： 2186-1889

    eISSN： 2187-4700

  76. ロボット支援腎部分切除後のisolated calyxにより尿瘻が遷延した症例

    三塚 浩二, 佐藤 新, 高橋 正博, 佐藤 琢磨, 川守田 直樹, 山下 慎一, 伊藤 明宏, 荒井 陽一

    Japanese Journal of Endourology　30　(3)　244-244　2017/11

    Publisher: (一社)日本泌尿器内視鏡学会

    ISSN： 2186-1889

    eISSN： 2187-4700

  77. 新しい前立腺癌Grading systemを用いた手術療法、放射線療法、内分泌療法の治療成績

    折笠 一彦, 佐藤 琢磨, 今野 将人

    泌尿器外科　30　(8)　1317-1319　2017/08

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  78. 気仙沼市立病院における震災前後の新規透析患者の推移

    阿部 倫明, 折笠 一彦, 佐藤 琢磨, 横田 憲一, 大友 浩志, 芹澤 玄, 佐藤 美智代, 尾形 百合, 及川 明子, 加藤 維, 小山 咲子, 清元 秀泰, 宮崎 真理子, 伊藤 貞嘉, 安海 清

    日本透析医学会雑誌　50　(Suppl.1)　817-817　2017/05

    Publisher: (一社)日本透析医学会

    ISSN： 1340-3451

    eISSN： 1883-082X

  79. 胚細胞腫瘍予後不良群において肺転移病変の最大径は予後不良因子である

    藤井紳司, 山下慎一, 山田成幸, 佐藤琢磨, 嶋田修一, 泉秀明, 川崎芳英, 川守田直樹, 三塚浩二, 伊藤明宏, 荒井陽一

    日本泌尿器科学会東部総会プログラム・抄録集　82nd　335　2017

  80. ロボット支援腹腔鏡下前立腺全摘術と恥骨後式前立腺全摘術の術後QOLの比較

    高橋正博, 三塚浩二, 山下慎一, 佐藤琢磨, 川崎芳英, 泉秀明, 川守田直樹, 海法康裕, 伊藤明宏, 荒井陽一

    泌尿器科再建再生研究会プログラム・抄録集　14th　49　2017

  81. 膀胱原発MALTリンパ腫の一例

    今野 将人, 佐藤 琢磨, 折笠 一彦

    泌尿器外科　29　(12)　1798-1798　2016/12

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  82. 骨盤臓器脱手術後の長期QOL評価

    折笠 一彦, 佐藤 琢磨, 今野 将人

    日本女性骨盤底医学会誌　13　(1)　178-181　2016/12

    Publisher: 日本女性骨盤底医学会

    ISSN： 2187-5669

    eISSN： 2434-8996

  83. 前立腺癌尿管転移の一例

    今野 将人, 佐藤 琢磨, 折笠 一彦, 渡辺 みか

    泌尿器外科　29　(9)　1495-1495　2016/09

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  84. 膀胱子宮内膜症の一例

    今野 将人, 佐藤 琢磨, 折笠 一彦

    泌尿器外科　29　(9)　1502-1502　2016/09

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  85. 筋層非浸潤性膀胱癌症例の再発、予後の臨床病理学的解析

    折笠 一彦, 佐藤 琢磨, 今野 将人

    泌尿器外科　29　(臨増)　927-927　2016/05

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  86. 宮城県気仙沼市における夜間頻尿の季節性変動

    木村 信吾, 佐藤 琢磨, 折笠 一彦, 中川 晴夫, 荒井 陽一

    日本泌尿器科学会総会　104回　OP-137　2016/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  87. 当院における去勢抵抗性前立腺癌に対するカバジタキセルの使用経験

    今野 将人, 佐藤 琢磨, 折笠 一彦

    日本泌尿器科学会総会　104回　PP3-318　2016/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  88. 陰茎海綿体膿瘍の1例

    小山 淳太朗, 並木 俊一, 明円 真吾, 佐藤 琢磨, 山下 慎一, 安達 尚宣, 海法 康裕, 中川 晴夫, 荒井 陽一

    泌尿器外科　29　(2)　186-186　2016/02

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  89. ゲムシタビン+シスプラチン療法に反応した前立腺導管癌の2例

    神山 佳展, 三塚 浩二, 勝又 有記, 高橋 正博, 伊藤 淳, 佐藤 琢磨, 川崎 芳英, 川守田 直樹, 中川 晴夫, 荒井 陽一, 棚橋 善克, 渡辺 みか

    泌尿器外科　29　(2)　192-193　2016/02

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  90. 卵巣静脈浸潤を経て下大静脈腫瘍塞栓をきたした腎癌の1例

    木村 信吾, 佐藤 琢磨, 折笠 一彦

    泌尿器外科　29　(2)　197-197　2016/02

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  91. 当院におけるHo:YAGレーザーを用いた上部尿路結石内視鏡治療の初期経験について

    佐藤 琢磨, 今野 将人, 折笠 一彦

    Japanese Journal of Endourology　28　(3)　260-260　2015/11

    Publisher: (一社)日本泌尿器内視鏡学会

    ISSN： 2186-1889

    eISSN： 2187-4700

  92. 膀胱癌症例の臨床病理学的再発、予後因子の解析

    折笠 一彦, 佐藤 琢磨, 今野 将人

    日本癌治療学会誌　50　(3)　1906-1906　2015/09

    Publisher: (一社)日本癌治療学会

    ISSN： 0021-4671

  93. 当院で経験したS状結腸膀胱瘻の2例

    佐藤 琢磨, 木村 信吾, 折笠 一彦, 横田 憲一

    泌尿器外科　28　(臨増)　864-864　2015/05

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  94. 東日本大震災による夜間頻尿への影響

    木村 信吾, 佐藤 琢磨, 折笠 一彦, 中川 晴夫

    日本泌尿器科学会総会　103回　487-487　2015/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  95. 切除不能膀胱癌の膀胱出血に対する経尿道的蒸散術(TURisV)の有効性

    木村 信吾, 佐藤 琢磨, 折笠 一彦

    Japanese Journal of Endourology　27　(3)　217-217　2014/11

    Publisher: (一社)日本泌尿器内視鏡学会

    ISSN： 2186-1889

    eISSN： 2187-4700

  96. 転移リンパ節に対する超音波と微小気泡を利用したリンパ行性薬剤送達法の開発(development of intralymphatic drug delivery system for metastatic lymph nodes by sonoporation with nano/micro bubbles)

    白井 優子, 佐藤 琢磨, 阪本 真弥, 森 士朗, 小玉 哲也

    日本癌学会総会記事　73回　P-3379　2014/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  97. 勃起障害治療への新テクノロジーの応用 超音波および低強度体外衝撃波の治療応用の可能性

    佐藤 琢磨, 折笠 一彦, 荒井 陽一

    日本性機能学会雑誌　29　(2)　170-170　2014/08

    Publisher: (一社)日本性機能学会

    ISSN： 1345-8361

  98. 限局性前立腺癌に対する内分泌療法、放射線療法、手術療法の治療成績

    折笠 一彦, 江里口 智大, 木村 信吾, 佐藤 琢磨

    泌尿器外科　27　(8)　1315-1318　2014/08

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  99. 限局性前立腺癌に対する放射線外照射療法の治療成績

    折笠 一彦, 佐藤 琢磨, 江里口 智大, 木村 信吾

    日本癌治療学会誌　49　(3)　2645-2645　2014/06

    Publisher: (一社)日本癌治療学会

    ISSN： 0021-4671

  100. 男性重症尿失禁に対する人工尿道括約筋埋め込み術 治療成績とQOL

    海法 康裕, 川守田 直樹, 佐藤 真彦, 佐藤 琢磨, 栫井 成彦, 中川 晴夫, 荒井 陽一

    泌尿器外科　27　(4)　521-521　2014/04

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  101. 下大静脈腫瘍塞栓の遊離による肺塞栓に対し、観血的治療を行い救命し得た腎細胞癌の2例

    嶋田 修一, 齋藤 英郎, 三塚 浩二, 川守田 直樹, 佐藤 琢磨, 木田 智, 伊藤 明宏, 中川 晴夫, 荒井 陽一

    泌尿器外科　27　(4)　522-522　2014/04

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  102. 前立腺全摘術後の性機能障害の経時的変化および関連する因子について

    大原 慎也, 海法 康弘, 佐藤 琢磨, 福士 太郎, 泉 秀明, 山下 慎一, 並木 俊一, 中川 晴夫, 荒井 陽一

    泌尿器外科　27　(4)　533-533　2014/04

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  103. マウス転移リンパ節モデルに対する低出力超音波と微小気泡を用いた抗がん剤治療に関する研究

    佐藤 琢磨, 阪本 真弥, 森 士朗, 荒井 陽一, 小玉 哲也

    日本泌尿器科学会総会　102回　622-622　2014/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  104. 2A15 Development of drug delivery system to the secondary lymph node after dissection

    OUCHI Tomoki, LENAN Shao, KATO Shigeki, SHIRAI Yuko, SATO Takuma, SAKAMOTO Maya, MORIKAWA Hidehiro, MORI Shiro, KODAMA Tetsuya

    2014　(26)　259-260　2014/01/10

    Publisher: The Japan Society of Mechanical Engineers

  105. 2B24 Application of blood vessel imaging using contrast enhanced high frequency ultrasound to diagnosis of early lymph node metastasis in an early stage

    TAKEMURA Tomoaki, SATO Takuma, KATO Shigeki, SAKAMOTO Maya, MORI Shiro, ARAI Youichi, KODAMA Tetsuya

    2014　(26)　307-308　2014/01/10

    Publisher: The Japan Society of Mechanical Engineers

  106. リンパ節担がんマウスに対する超音波と微小気泡をもちいた抗がん剤治療に関する研究

    佐藤 琢磨, 荒井 陽一

    Japanese Journal of Endourology　26　(3)　308-308　2013/11

    Publisher: (一社)日本泌尿器内視鏡学会

    ISSN： 2186-1889

    eISSN： 2187-4700

  107. リンパ節癌細胞移植マウスに対する超音波およびナノマイクロバブルをもちいたドラッグデリバリーに関する研究(Drug delivery to the mouse model of tumor bearing lymphnode with nano/microbubbles and ultrasound)

    佐藤 琢磨, 阪本 真弥, 森 士朗, 荒井 陽一, 小玉 哲也

    日本癌学会総会記事　72回　474-474　2013/10

    Publisher: 日本癌学会

    ISSN： 0546-0476

  108. J023014 Molecular delivery system into lymph nodes using ultrasound and nanobubbles

    Shirai Yuko, Kato Shigeki, Sato Takuma, Kanzaki Hiroyuki, Mori Shiro, Kodama Tetsuya

    Mechanical Engineering Congress, Japan　2013　"J023014-1"-"J023014-5"　2013/09/08

    Publisher: The Japan Society of Mechanical Engineers

    More details Close

    Appropriate treatment of lymph node metastasis is essential to improve the prognosis for patients. Although lymph node dissection is a primary option, it is invasive and associated with adverse effects. The development of novel, non-invasive therapeutic methods in preclinical experiments using mice has been restricted by the small lymph node size (only a few millimeters in diameter) and the limited techniques available for non-invasive monitoring of the progression of lymph node metastasis. Here, we show a local drug delivery using nanobubbles and ultrasound via lymphatic vessels shows potential as a non-invasive treatment for tumors in the proper axillary lymph nodes (proper-ALNs) of MXHIO/Mo-Ipr/lpr mice, which develop systemic swelling of lymph nodes (up to 13 mm in diameter, similar in size to human lymph nodes). Tumor cells were inoculated into the proper-ALNs to develop a model of metastatic lesions, and any anti-tumor effects of therapy were assessed with an in vivo bioluminescence imaging system, a high-frequency ultrasound system, and immunohistochemical analysis. We confirmed the successful noninvasive deliveiy of small molecule (TOTO-3 iodide) into lymphocytes invaded by cancer. Our system has a potential for a novel local delivery system for the treatment of lymph node metastasis.

  109. 超音波と微小気泡によるリンパ管を介したリンパ節内細胞への外来分子導入法の開発

    加藤 茂樹, 白井 優子, 佐藤 琢磨, 菅崎 弘幸, 本園 千尋, 宮澤 正顯, 森 士朗, 小玉 哲也

    超音波医学　40　(3)　307-307　2013/05

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  110. 転移リンパ節モデルへの微小気泡と超音波をもちいたドラッグデリバリーに関する研究

    佐藤 琢磨

    超音波医学　40　(Suppl.)　S441-S441　2013/04

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  111. 乳がんにおける腫瘍周辺上皮組織のリンパ管および血管分布に関する研究(The distribution of lymphatic and blood vessels in the peritumoral epithelium tissue in breast cancer)

    三浦 由宣, 佐藤 琢磨, 阪本 真弥, 森 士朗, 小玉 哲也

    日本癌学会総会記事　71回　492-493　2012/08

    Publisher: 日本癌学会

    ISSN： 0546-0476

  112. 前立腺全摘術後のPad free rateの経時的変化および関連する因子について

    佐藤 琢磨, 海法 康裕, 大原 慎也, 石戸谷 滋人, 荒井 陽一

    泌尿器外科　25　(臨増)　1118-1118　2012/05

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  113. 前立腺全摘術後の性機能障害の経時的変化および関連する因子について

    大原 慎也, 海法 康裕, 佐藤 琢磨, 石戸谷 滋人, 荒井 陽一

    日本泌尿器科学会雑誌　103　(2)　436-436　2012/03

    Publisher: (一社)日本泌尿器科学会

    ISSN： 0021-5287

    eISSN： 1884-7110

  114. 7E36 Drug Delivery System for the Lymphatic Metastases.

    KATO Shigeki, HORIE Sachiko, SATO Takuma, KODAMA Tetsuya

    2012　(24)　"7E36-1"-"7E36-2"　2012/01/06

    Publisher: The Japan Society of Mechanical Engineers

  115. 精巣カルチノイドの1例

    渋谷 彰良, 竹田 篤史, 並木 俊一, 佐藤 琢磨, 沼田 功, 坂元 和宏

    泌尿器外科　25　(1)　120-120　2012/01

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  116. 高齢者に発生した精巣腫瘍の1例

    佐藤 琢磨, 伊藤 淳, 徳山 聡, 浅野 重之

    泌尿器外科　25　(1)　130-130　2012/01

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  117. 後腹膜脂肪肉腫の1例

    佐藤 琢磨

    泌尿器外科　25　(1)　133-133　2012/01

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  118. 肩甲帯離断術を要した腎癌骨転移の一例

    伊藤 淳, 佐藤 琢磨, 徳山 聡, 佐竹 洋平

    泌尿器外科　25　(1)　136-136　2012/01

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  119. 前立腺全摘術後の性機能障害の経時的変化および関連する因子について

    大原 慎也, 海法 康裕, 佐藤 琢磨, 石戸谷 滋人, 荒井 陽一

    日本性機能学会雑誌　26　(2)　165-165　2011/09

    Publisher: (一社)日本性機能学会

    ISSN： 1345-8361

  120. 停留精巣を有するダウン症に発生し、化学療法関連死を来した進行性精巣腫瘍の1例

    木田 智, 山田 成幸, 佐藤 琢磨, 嶋田 修一, 大原 慎也, 宮里 実, 齋藤 英郎, 伊藤 明宏, 石戸谷 滋人, 荒井 陽一

    日本癌治療学会誌　46　(2)　713-713　2011/09

    Publisher: (一社)日本癌治療学会

    ISSN： 0021-4671

  121. 東北大学における前立腺小細胞癌の治療経験

    佐藤 琢磨, 石戸谷 滋人, 青木 大志, 伊藤 明宏, 渡邉 みか, 荒井 陽一

    泌尿器外科　24　(8)　1365-1367　2011/08

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  122. 【前立腺癌(第2版)-基礎・臨床研究のアップデート-】 臨床 前立腺癌の治療 外科治療 恥骨後式前立腺全摘除術

    荒井 陽一, 海法 康裕, 佐藤 琢磨, 川守田 直樹, 石戸谷 滋人

    日本臨床　69　(増刊5 前立腺癌)　334-338　2011/06

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  123. 前立腺全摘術後のPad free rateの経時的変化および関連する因子について

    佐藤 琢磨, 海法 康裕, 石戸谷 滋人, 荒井 陽一

    日本泌尿器科学会雑誌　102　(2)　543-543　2011/03

    Publisher: (一社)日本泌尿器科学会

    ISSN： 0021-5287

    eISSN： 1884-7110

  124. 前立腺全摘術後のPad free rateの経時的変化について

    佐藤 琢磨, 海法 康裕, 石戸谷 滋人, 荒井 陽一

    Japanese Journal of Endourology and ESWL　23　(3)　215-215　2010/10

    Publisher: (一社)日本泌尿器内視鏡学会

    ISSN： 0914-9635

  125. 子宮内膜症による尿管狭窄の2例

    佐藤 琢磨, 竹田 篤史, 山田 成幸, 沼田 功, 坂元 和宏

    泌尿器外科　22　(11)　1469-1469　2009/11

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  126. 陰茎結核疹の1例

    佐藤 琢磨, 竹田 篤史, 山田 成幸, 沼田 功, 蔵本 陽子, 玉渕 尚宏, 坂元 和宏

    泌尿器外科　22　(11)　1475-1475　2009/11

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  127. 高齢者に発生した精巣胚細胞腫瘍の1例

    佐藤 琢磨, 伊藤 淳, 徳山 聡

    泌尿器外科　22　(10)　1357-1360　2009/10

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  128. 限局性前立腺癌に対する根治的外照射 大崎市民病院の治療成績

    竹田 篤史, 山田 成幸, 佐藤 琢磨, 沼田 功, 壺井 匡浩, 高橋 ちあき, 大田 英揮

    大崎市民病院誌　12　(1)　35-38　2008/12

    Publisher: 大崎市民病院

    ISSN： 1881-6142

  129. 精巣カルチノイドの1例

    渋谷 彰良, 竹田 篤史, 並木 俊一, 佐藤 琢磨, 沼田 功, 坂元 和宏

    大崎市民病院誌　12　(1)　77-79　2008/12

    Publisher: 大崎市民病院

    ISSN： 1881-6142

  130. 陰茎結核疹の1例

    佐藤 琢磨, 竹田 篤史, 山田 成幸, 沼田 功, 蔵本 陽子, 玉渕 尚宏, 坂元 和宏

    泌尿器外科　21　(2)　201-204　2008/02

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  131. 当院における腹腔鏡下手術の検討

    佐藤琢磨, 竹田篤史, 山田成幸, 沼田功

    泌尿器外科　21　(臨増)　436-436　2008

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  132. 右心室転移をきたした左腎細胞癌の1例

    佐藤 琢磨, 竹田 篤史, 山田 成幸, 沼田 功, 坂本 和弘

    泌尿器外科　21　(1)　107-107　2008/01

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  133. 後腹膜鏡下尿管皮膚瘻造設術と対側尿管の結紮 片側からのアプローチ

    竹田 篤史, 山田 成幸, 佐藤 琢磨, 沼田 功

    泌尿器外科　21　(1)　109-109　2008/01

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  134. 大崎市民病院における根治的前立腺全摘除術症例の臨床的検討

    山田 成幸, 竹田 篤史, 佐藤 琢磨, 沼田 功

    大崎市民病院誌　11　(1)　33-36　2007/12

    Publisher: 大崎市民病院

    ISSN： 1881-6142

  135. 子宮内膜症による尿管狭窄の2例

    佐藤 琢磨, 竹田 篤史, 山田 成幸, 沼田 功, 坂元 和宏

    大崎市民病院誌　11　(1)　97-100　2007/12

    Publisher: 大崎市民病院

    ISSN： 1881-6142

  136. 腎リンパ管腫の1例

    佐藤 琢磨, 竹田 篤史, 山田 成幸, 沼田 功, 坂元 和宏

    超音波医学　34　(6)　595-597　2007/11

    Publisher: (公社)日本超音波医学会

    DOI： 10.3179/jjmu.34.595 　

    ISSN： 1346-1176

    eISSN： 1881-9311

  137. 前立腺全摘術直後に輸血関連急性肺障害(transfusion related acute lung injury:TRALI)を呈した1例

    佐藤 琢磨, 竹田 篤史, 山田 成幸, 沼田 功

    泌尿器外科　20　(5)　726-726　2007/05

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  138. 限局性前立腺に対する根治的外照射 当院の治療成績

    竹田 篤史, 山田 成幸, 佐藤 琢磨, 沼田 功, 壷井 匡浩, 高橋 ちあき, 大田 英揮

    泌尿器外科　20　(臨増)　589-589　2007/05

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  139. 腎リンパ管腫の1例

    佐藤 琢磨, 竹田 篤史, 山田 成幸, 沼田 功, 坂本 和宏

    超音波医学　34　(Suppl.)　S472-S472　2007/04

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  140. 大崎市民病院における根治的前立腺全摘除術症例の臨床的検討

    山田 成幸, 佐藤 琢磨, 竹田 篤史, 沼田 功

    日本泌尿器科学会雑誌　98　(2)　501-501　2007/02

    Publisher: (一社)日本泌尿器科学会

    DOI： 10.5980/jpnjurol.98.501_1 　

    ISSN： 0021-5287

    eISSN： 1884-7110

  141. 大崎市民病院泌尿器科での腹腔鏡下手術の検討

    沼田 功, 竹田 篤史, 山田 成幸, 佐藤 琢磨

    大崎市民病院誌　10　(1)　25-27　2006/12

    Publisher: 大崎市民病院

    ISSN： 1881-6142

  142. 後腹膜鏡下尿管皮膚瘻造設術と対側尿管の結紮 片側からのアプローチ

    竹田 篤史, 山田 成幸, 佐藤 琢磨, 沼田 功

    Japanese Journal of Endourology and ESWL　19　(3)　236-236　2006/10

    Publisher: (一社)日本泌尿器内視鏡学会

    ISSN： 0914-9635

  143. 古川市でのPSA前立腺癌検診と超音波ガイド下前立腺生検結果

    佐藤 琢磨, 竹田 篤史, 沼田 功

    超音波医学　33　(3)　397-398　2006/05

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  144. 全尿路真菌症による腎不全症例

    嶋田 修一, 中川 晴夫, 伊藤 明宏, 斉藤 誠一, 新宅 一郎, 青木 大志, 三塚 浩二, 佐藤 琢磨, 荒井 陽一

    泌尿器外科　19　(3)　286-286　2006/03

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  145. 膀胱癌患者における仮想膀胱鏡の試み

    齋藤 敏典, 中川 晴夫, 新宅 一郎, 佐藤 琢磨, 荒井 陽一

    泌尿器外科　19　(3)　292-292　2006/03

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  146. 悪性膀胱パラガングリオーマの一例

    海法 康裕, 石戸谷 滋人, 斉藤 誠一, 沼畑 健司, 並木 修一, 三塚 浩二, 佐々木 光晴, 佐藤 琢磨, 荒井 陽一

    泌尿器外科　19　(2)　186-186　2006/02

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  147. 前立腺全摘除術直後に輸血関連急性肺障害(transfusion related acute lung injury,TRALI)を呈した1例

    佐藤琢磨, 竹田篤史, 山田成幸, 沼田功

    大崎市民病院誌　10　(1)　79-81　2006

    Publisher: 大崎市民病院

    ISSN： 1881-6142

  148. 腎動脈遮断による後腹膜鏡下腎部分切除術を施行した4例

    新宅 一郎, 佐藤 琢磨, 齋藤 英郎, 伊藤 明宏, 竹田 篤史, 石戸谷 滋人, 及川 克彦, 坂井 清英, 斎藤 誠一, 荒井 陽一

    Japanese Journal of Endourology and ESWL　16　(2)　111-111　2003/10

    Publisher: (一社)日本泌尿器内視鏡学会

    ISSN： 0914-9635

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Research Projects 7

  1. 低活動膀胱に対する低出力衝撃波およびPDE5阻害薬を用いた新規治療法の開発

    佐藤 琢磨

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 若手研究

    Institution: 東北大学

    2021/04/01 - 2024/03/31

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    排尿筋低活動（detrusor underactivity: DU）/低活動膀胱(underactive bladder: UAB)は排尿筋収縮力/排尿筋収縮時間の減少により尿排泄の効率が低下する膀胱機能障害であり、下部尿路症状（lower urinary tract symptoms: LUTS）を有する多くの症例の病態に関与することが明らかとなっている。現在、DU/UABに対して有効性が証明された治療法は存在せず、低侵襲で効果の高い新規治療法の開発が望まれている。DU/UABの原因は多岐にわたることが知られているが、近年、膀胱の慢性的な血流障害とDU/UABの関連が報告されている。本研究では慢性的な血流障害に起因するDU/UABに着目し、PDE5阻害薬と低出力衝撃波照射の併用による新規治療法の開発を目的としている。PDE5阻害薬と低出力衝撃波照射はどちらも慢性的な血流障害に対して血流改善、抗炎症作用、酸化ストレスの軽減、血管内皮細胞の機能改善などの生物学的作用を持つことが知られている。本研究では、腸骨動脈（総腸骨および外腸骨動脈）の内腔を機械的に擦過することにより、腸骨動脈の動脈硬化が惹起されるラット動物モデルを用いる。この動物モデルは動脈擦過回数および擦過から経過した時間と動脈硬化および骨盤の血流障害の程度が相関すること知られている。本年度はまず、様々な条件（動脈の擦過回数および擦過からの期間）でどの程度の動脈硬化および骨盤の血流障害が惹起されるか、またその際の排尿/蓄尿に関するパラメーターについての検討を行っており、現在のその結果を解析している最中である。

  2. A new treatment of non-muscle invasive bladder cancer with ultrasound-assisted intravesical chemotherapy.

    SATO TAKUMA

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Early-Career Scientists

    2018/04/01 - 2021/03/31

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    Ultrasound (US) irradiation in the presence of US contrast agents induces transient and reversible membrane poration of target cells that enhances delivery of exogenous molecules and improves the antitumor activity of chemotherapeutic drugs. In the present study, the synergistic antitumor activity of chemotherapeutic drugs combined with microbubbles (MBs) and US exposure on bladder cancer cells (in vitro) and experimental bladder cancer model (in vivo) was investigated. In the specific condition, cell viability was significantly lower in the chemotherapeutic drugs + MBs + US group than in the chemotherapeutic drugs + MBs and US + MBs groups. In vivo study showed that, in comparison with other groups, the chemotherapeutic drugs + MBs + US group expressed higher antitumor activity against tumor in the bladder, although statistical significance was not reached.

  3. Development of approach to improve functional outcome after robot-assisted radical prostatectomy

    ARAI Yoichi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2018/04/01 - 2021/03/31

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    Pelvic hemodynamics in rat was evaluated by stimulating pelvic nerve, which branched out from sacral nerve. Neuromodulation increased blood flow to bladder, prostate, and penis via stimulation of pelvic nerves. This study enrolled patients with localized prostate cancer who underwent MRI before radical prostatectomy. Continence was evaluated using the Expanded Prostate Index Composite (EPIC) instrument before surgery and at 1, 3, 6, and 12 months after surgery. Minimal residual membranous urethral length (mRUL) was measured the distance between the lower margins of the puboperinealis and bulbospongiosus muscles in a direction parallel with the urethra on preoperative MRI. Preoperative mRUL was associated with continence after radical prostatectomy.

  4. elucidating the pathophysiology of chronic pelvic pain syndrome via neural cross-sensitization among pelvic organs and development of new treatment

    Kawamorita Naoki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2017/04/01 - 2020/03/31

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    Chronic pelvic pain syndrome (CPPS) is one of the intractable diseases defined as the occurrence of persistent pelvic pain in the absence of other identifiable cause such as infection or cancer in the bladder. In order to, elucidate the pathology, we paid attention cross-sensitization among pelvic organs which means the theory of pathology that one pelvic organ with pathogen causes significant effects on another non-inflammatory pelvic organ. The bladder hypersensitivity and significantly high level of TRPA1 in the bladder and the dorsal route ganglions bladder were demonstrated in the endometoriosis rats. Once LH-RH antagonist was injected to treat endometoriosis, bladder function was ameliorated and the level of TRIPA1 at the bladder and DRG was resumed, suggesting that endometoriosis caused bladder hypersensitivity via hyperfunction of TRIPA1 in association with cross-sensitization among the pelvic organs.

  5. Glycoconjugate biomarker of Prostate cancer

    Ito Akihiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2017/04/01 - 2020/03/31

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    DSGb5 is a ganglioside originally isolated from tissue extracts of renal cell carcinoma with metastasis. Previous study revealed that DSGb5 expression in prostatectomy specimens can predict PSA recurrence after radical prostatectomy. In this study, we investigated the relationship between DSGb5 expression in prostate biopsy specimen and prognosis after radical treatment for prostate cancer. DSGb5 expression in prostate biopsy specimen can predict lymphovascular invasion of prostatectomy specimens and PSA recurrence after radical prostatectomy. And more DSGb5 expression in biops specimen can predict biochemical recurrence following radiation therapy. Thus, DSGb5 expression at clinical diagnosis of prostate cancer can be a predictor of the patients receiving radical therapy for prostate cancer.

  6. A novel immunotherapy for advanced renal cell carinoma by glycobiological interaction with natural killer cells

    Kawasaki Yoshihide

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2017/04/01 - 2020/03/31

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    We reported new immunotherapy with activated NK cells therapy by regulating glycoantigen DSGb5 on renal cancer cells. However, when there was small expression of DSGb5 of tumor we found that anticancer effect by activated NK cells was so restricted. We faced difficult task to quantify DSGb5 expressing on renal cancer cells to select the patients adaptable to activated NK cells therapy. Therefore, we needed to quantify glycoatnigen DSGb5 on renal cancer cells. DSGb5 consists of carbohydrate chain and sphingolipid which have variety of fatty acids. First of all, we estimated expression level of DSGb5 by calculating 8 fatty acids with 16 carbons to 26 carbons. However, standard substance of DSGb5 were necessary to accurate quantify DSGb5 of tumor. And then we established experimental system of chemical synthesis of DSGb5, at last we were able to synthase DSGb5 chemically to accurate quantify by mass spectrometer.

  7. Establishment of nerve sparing procedure to improve functional outcome of radical prostatectomy

    Arai Yoichi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2014/04/01 - 2018/03/31

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    Prospective study demonstrated that minimal residual urethral length (mRUL) on preoperative MRI is associated with preoperative urinary function and predicts postoperative urinary continence recovery (Satake Y, Urology, 2018). Using nerve-sparing rat model we originally developed, we revealed that use of tissue sealing sheet attenuated postoperative inflammatory changes and oxidative stress and improved erectile function after cavernous nerve injury in rats（Yamashita S , J Sex Med. 2016;）. Based on the findings, randomized clinical controlled study on the efficacy of tissue sealing sheet in robot-assisted radical prostatectomy is ongoing. The interim analyses will be reported in 2018 Annual Meeting of American Urological Association. Using rat model, it was demonstrated that sacral surface therapeutic electrical stimulation increases blood flow of penis and bladder, suggesting the possible role of improving functional outcome after radical prostatectomy.

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