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Hiroaki Tomita

Section

Graduate School of Medicine

Job title

Professor

Degree

博士（医学）（岡山大学）

researchmap

https://researchmap.jp/hiroakitomita

J-GLOBAL ID

201801014087738123

Research History 7

2018/12 - Present

Tohoku University　Graduate School of Medicine
2012/04 - Present

International Research Institute for Disaster Psychiatry　Professor
2008 - 2012/03

東北大学医学(系)研究科(研究院)　准教授
1998 - 1999

Nagasaki University　School of Medicine
2007 -

東北大学医学系研究科・大学院　准教授
2007 -

東北大学医学(系)研究科(研究院)　助教授
2006 -

Tohoku University　Graduate School of Medicine

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Education 2

Okayama University　Graduate School, Division of Medicine

- 1995/03/31
Okayama University　Faculty of Medicine　Medicine

- 1989/03/31

Committee Memberships 10

生物学的精神医学会脳バンク設立準備委員会　委員

2007/07 - Present
生物学的精神医学会脳バンク設立準備委員会　委員

2007/07 - Present
理化学研究所脳科学総合研究センター　脳バンク・ネットワーク設立検討委員

2006/10 - Present
理化学研究所脳科学総合研究センター　脳バンク・ネットワーク設立検討委員

2006/10 - Present
日本統合失調症学会　評議員

2006/04 - Present
日本統合失調症学会　評議員

2006/04 - Present
日本精神・行動遺伝学会　評議員

1995/10 - Present
日本精神・行動遺伝学会　評議員

1995/10 - Present
日本精神神経学会　編集委員

1990/10 - Present
日本精神神経学会　編集委員

1990/10 - Present

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Professional Memberships 7

Society for Neuroscience(2002/10-)
日本精神神経学会(1990/10- 編集委員)
日本生物学的精神医学会(1990/10- ブレインバンクネットワーク設立委員)
日本人類遺伝学会(1997/10- 論文査読者)
日本精神・行動遺伝学会(1995/10- 評議員)
日本うつ病学会(2007/06-)
日本統合失調症学会(2006/04- 評議員)

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Research Interests 23

災害精神医学
個別化医療
精神疾患
神経科学
脳・神経
遺伝子
前頭前野
ゲノム
統合失調症
情動
脳神経疾患
認知
ドーパミン
薬理学
遺伝子発現
マイクロアレイ
精神薬理学
ゲノム創薬
連鎖解析
気分安定薬
発作性運動誘発性コレオアテトーシス
包括脳ネットワーク
統合脳・病態脳

Research Areas 1

Life sciences / Psychiatry /

Papers 340

Weekly Changes in the Clozapine Concentration-to-Dose Ratio During Clozapine Titration in Japanese Patients With Schizophrenia

Yuki Kikuchi, Mutsumi Sakata, Kazuro Ikawa, Daisuke Kume, Naoki Horikawa, Hiroshi Komatsu, Hiroaki Tomita

Journal of Clinical Psychopharmacology　2025/04/07
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI： 10.1097/jcp.0000000000002003 　

ISSN： 0271-0749

eISSN： 1533-712X

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Abstract Background To prevent inflammatory side effects early in the titration phase of clozapine, international guidelines recommend measuring clozapine blood levels weekly. However, data on such measurements are lacking. Methods We retrospectively reviewed the medical records of all patients with schizophrenia who were treated with clozapine for the first time and whose clozapine blood levels were measured for at least 2 consecutive weeks from clozapine initiation at our institution from 2020 to 2024. Patients were divided into 2 groups based on whether they had a fever during the first 6 weeks of clozapine treatment. The clozapine concentration-to-dose (C/D) ratios were compared weekly within 6 weeks after starting clozapine. Results A total of 28 patients were included in the study, of whom 6 developed a fever and 22 did not. The median C/D ratios in weeks 1 and 2 were significantly higher in patients with a fever than in those without (week 1: 2.12 vs 1.31, P = 0.0217; week 2: 3.48 vs 1.23, P = 0.01). There was no significant difference in C/D ratios between the groups from week 3 to week 6. During the first 6 weeks of treatment, C/D ratios increased markedly and showed peaks in patients with fever but remained stable in patients without fever. Conclusions Measuring clozapine blood levels early in the titration phase helps estimate the metabolic capacity of patients. Furthermore, it is essential to pay attention to inflammation, which may increase clozapine C/D ratios.
Effects of pharmacological inhibition of FABP4 during gestation and lactation on offspring neurodevelopment and behavior. International-journal

Sun Zhengkang, Hinako Kirikae, He Xiaofeng, Fumiko Yoshimachi, Minori Ikuta, Tetsuo Ohnishi, Yui Yamamoto, Hirofumi Miyazaki, Yoshiyuki Kasahara, Mai Sakai, Zhiqian Yu, Noriko Osumi, Hiroaki Tomita, Yuji Owada, Motoko Maekawa

Neuroscience letters　853　138199-138199　2025/03/14

DOI： 10.1016/j.neulet.2025.138199 　

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Fatty acid-binding protein 4 (FABP4), a key regulator of lipid metabolism and inflammation, has been implicated in neurodevelopmental disorders, including autism spectrum disorder (ASD). This study investigated the effects of FABP4 inhibition during gestation and lactation on offspring neurodevelopment using the selective FABP4 inhibitor BMS309403. Female mice received BMS309403 (15 mg/kg) via oral gavage from two weeks before mating to postnatal day 28 (P28). Administration of BMS309403 to mouse dams resulted in autism-like phenotypes in male offspring (behavioral tests: n = 7-10 per group; spine analysis: 6 mice per group, n = 26-38 dendrites per group), characterized by increased dendritic spine density in the prefrontal cortex, impaired vocal communication, increased repetitive behaviors, and depression-like symptoms. Fatty acid analysis (n = 4-6 per group) revealed significant alterations in maternal and fetal lipid profiles, including elevated arachidonic acid levels in maternal plasma and increased n6PUFAs in the fetal brain, suggesting a pro-inflammatory lipid environment. Principal component analysis demonstrated distinct clustering of lipid profiles between control and BMS309403-treated groups. Cytokine analysis (n = 6 per group) indicated reductions in IL-10 and IL-12(p40) in maternal plasma and decreased TNFα in the fetal plasma, suggesting dysregulation in systemic inflammatory signaling. These findings suggest that FABP4 inhibition during the perinatal period perturbs lipid metabolism and may influence neurodevelopment through systemic metabolic changes. Although the direct effects of BMS309403 on the fetal brain cannot be excluded, alteration in maternal metabolism and placental function may have contributed to the observed neurodevelopmental changes in offspring.
Mental health needs in the acute and subacute phases of the 2024 Noto Peninsula earthquake: Emergency Medical Information System data analysis in Disaster Psychiatric Assistance Team activities

Yasuto Kunii, Yumiko Hamaie, Mizuki Hino, Yusuke Utsumi, Yasuhisa Fukuo, Hiroaki Tomita

PSYCHIATRY AND CLINICAL NEUROSCIENCES REPORTS　4　(1)　2025/03

DOI： 10.1002/pcn5.70085 　

ISSN： 2769-2558
Experimenters' sex modulates anxiety-like behavior, contextual fear, and microglial oxytocin transcription in mice

Mai Sakai, Zhiqian Yu, Rosanne Picotin, Tomoko Kasahara, Yoshie Kikuchi, Chiaki Ono, Mizuki Hino, Yasuto Kunii, Yuko Maejima, Kenju Shimomura, Miharu Nakanishi, Takaaki Abe, Hatsumi Yoshii, Hiroaki Tomita

Behavioural Brain Research　115480-115480　2025/02
Publisher: Elsevier BV
DOI： 10.1016/j.bbr.2025.115480 　

ISSN： 0166-4328
COVID-19 outbreak in a ward led three patients to discontinue clozapine due to neutropenia: Call for urgent considerations regarding clozapine regulation in Japan

Yuki Kikuchi, Sota Ueno, Bunichiro Onodera, Hiroaki Tanifuji, Hiroshi Komatsu, Hiroaki Tomita

Schizophrenia Research　276　194-195　2025/02
Publisher: Elsevier BV
DOI： 10.1016/j.schres.2025.01.024 　

ISSN： 0920-9964
Inclination of antidepressant medication continuation during pregnancy between 2012 and 2023 in Japan: A cohort study. International-journal

Tomofumi Ishikawa, Takamasa Sakai, Aoi Noda, Saya Kikuchi, Natsuko Kobayashi, Hiroaki Tomita, M Hidekazu Nishigori, Shinichi Kuriyama, Nariyasu Mano, Taku Obara

Journal of affective disorders　2025/01/10

DOI： 10.1016/j.jad.2025.01.044 　

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BACKGROUND: As multiple Japanese academic societies have recently issued treatment guidelines for perinatal antidepressant treatments, it is considered worthwhile to evaluate the latest trends and continuation of antidepressant medication during pregnancy to optimize antenatal prescriptions. METHODS: The prevalence, trend, and continuation of antidepressant use during pregnancy in Japan from 2012 to 2023 were evaluated, using a large administrative claims database, in women whose pregnancies ended in live births. Annual changes were evaluated using a multivariate logistic regression model adjusted for maternal age at delivery. RESULTS: Of 179,797 women with a mean maternal age at delivery of 32.5 years, 1870 (1.04 %) were prescribed antidepressants during pregnancy. The prevalence significantly increased (P < 0.0001) from 0.63 % in 2012 to 1.67 % in 2023. Antidepressants were prescribed to 1730 women (0.96 %) during the first trimester. Of these, 670 (38.7 %) were antidepressant continuers throughout pregnancy, showing a significant increase (P < 0.0001) from 19.51 % in 2012 to 50.70 % in 2023. The most frequently prescribed class of antidepressants during pregnancy was serotonin reuptake inhibitors (0.74 %), especially sertraline (0.33 %) and escitalopram (0.23 %), with a significant increase in their annual prevalence. LIMITATIONS: Prescriptions for women whose pregnancies ended in abortion or stillbirth could not be evaluated. CONCLUSIONS: Given that antidepressant use and its continuation during pregnancy have become more common, it is important to further disseminate knowledge of the guidelines to healthcare professionals and women of childbearing age, including the promotion of preconception care and shared decision-making.
Autistic symptoms and clinical features of individuals at clinical high risk for psychosis and first-episode psychosis. International-journal

Hiroshi Komatsu, Yutaro Sato, Kazuho Tomimoto, Goh Onoguchi, Tasuku Matsuki, Yumiko Hamaie, Atsushi Sakuma, Noriyuki Ohmuro, Masahiro Katsura, Fumiaki Ito, Takashi Ono, Kazunori Matsumoto, Hiroaki Tomita

Asian journal of psychiatry　103　104345-104345　2024/12/17

DOI： 10.1016/j.ajp.2024.104345 　

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INTRODUCTION: Autistic symptoms in schizophrenia are reportedly associated with cognitive and social functions. However, few studies have investigated the association between autistic symptoms and clinical features in individuals with a clinical high risk for psychosis (CHR-P) and first-episode psychosis (FEP). We aimed to determine the association between autistic symptoms and clinical features in a cohort of individuals with CHR-P or FEP. METHODS: This cross-sectional study included 111 participants (CHR-P: 61, FEP: 50). Autistic symptoms were assessed using the Positive and Negative Syndrome Scale for Schizophrenia Autism Severity Scale. We assessed the association between autistic symptoms and global and social functioning, and cognitive function in individuals with CHR-P or EFP. Multiple regression analysis was also performed using age and sex as covariates to determine the association between autistic symptoms and global functioning. RESULTS: The participants with FEP had more severe autistic symptoms than those with CHR-P. The results of bivariate correlation analysis showed a significantly negative association of autistic symptoms with global and cognitive functions in both participants with CHR-P and those with FEP. Multiple regression analysis showed that sex, autistic symptoms, and positive symptoms were significant predictors of overall functioning in those participants. CONCLUSION: These findings suggest that autistic symptoms are associated with lower global functioning with both individuals at CHR-P and those with FEP. Further longitudinal analysis is needed to characterize the association between autistic symptoms and global functioning in CHR-P and FEP.
Relationship Between Clozapine-Induced Inflammation and Eosinophilia: A Retrospective Cohort Study. International-journal

Yuki Kikuchi, Yuji Otsuka, Fumiaki Ito, Yuji Yada, Hiroaki Tanifuji, Hiroshi Komatsu, Hiroaki Tomita

Schizophrenia bulletin　2024/12/16

DOI： 10.1093/schbul/sbae213 　

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BACKGROUND AND HYPOTHESIS: Eosinophilia has not been highlighted in clozapine-induced adverse inflammatory events, as it is often asymptomatic and self-limiting, while drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome occurs rarely. This study aimed to reveal the temporal relationships between eosinophilia and other inflammatory events during clozapine initiation. STUDY DESIGN: The temporal relationships between eosinophilia and other inflammatory events were evaluated among 241 patients with schizophrenia treated with clozapine for the first time at 7 hospitals. Risk factors for eosinophilia were investigated among preceding inflammatory events and other clinical characteristics. Furthermore, patients with eosinophilia were stratified by the severity of adverse inflammatory events and their clinical characteristics were compared. STUDY RESULTS: Of the 54 patients who experienced inflammatory adverse events, 27 (50%) developed eosinophilia. In all but 1 patient, clinical symptoms of inflammatory adverse events preceded eosinophilia. In contrast, of the 187 patients without inflammatory events, 21 (11%) developed eosinophilia. Multivariate analysis revealed that more severe preceding inflammatory adverse events were associated with a greater risk of eosinophilia. The median time to the first detection of eosinophilia and peak eosinophil count occurred significantly earlier in patients with severe adverse events than in asymptomatic patients. CONCLUSIONS: In most cases, eosinophilia developed after the onset of inflammatory symptoms. Preceding inflammation was associated with the development of clozapine-induced eosinophilia. Eosinophilia may not be suitable as an early detection marker of severe inflammatory adverse effects. These findings enhanced our understanding of the involvement of eosinophilia in clozapine-induced inflammatory events.
Evaluation of depression at 6 and 12 months postpartum by examining depressive symptoms and self-harm ideation during the early postpartum period: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Masatsugu Orui, Taku Obara, Mami Ishikuro, Aoi Noda, Genki Shinoda, Keiko Murakami, Noriyuki Iwama, Ippei Chiba, Kumi Nakaya, Rieko Hatanaka, Mana Kogure, Natsuko Kobayashi, Saya Kikuchi, Hirohito Metoki, Masahiro Kikuya, Naoki Nakaya, Atsushi Hozawa, Hiroaki Tomita, Shinichi Kuriyama

PCN reports : psychiatry and clinical neurosciences　3　(4)　e70025　2024/12

DOI： 10.1002/pcn5.70025 　

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AIM: The aim of this study was to evaluate depression at 6 and 12 months postpartum, using the Edinburgh Postpartum Depression Scale (EPDS) total score and its subitem regarding self-harm ideation (SHI) at 1 month postpartum. METHODS: A sample of 12,358 postpartum women answered the EPDS and questionaries at 1, 6, and 12 months postpartum longitudinally. RESULTS: For participants with postpartum depression (PPD; EPDS total score ≥9) and SHI (SHI sub-score ≥1) at 1 month postpartum, the risk of depression at 6 and 12 months postpartum (odds ratio [95% confidence interval] at 6 and 12 months postpartum: 20.03 [16.8-23.8] and 14.55 [12.3-17.2], respectively) was higher than for those with PPD but without SHI at 1 month postpartum (OR: 8.57 [7.36-10.0], and 6.24 [5.38-7.24], respectively). Additionally, SHI even without depressive symptoms at 1 month postpartum is also a risk for depression at 6 and 12 months postpartum. To support our longitudinal evaluation of depression at 6 and 12 months postpartum, these related factors were examined: traumatic events or relocations after the Great East Japan Earthquake, employment status, household income, personality traits, sleep status, psychological distress, and social networks. The result showed employment status, low household income and poor social networks were significantly associated with depression at 12 months postpartum but not at 6 months postpartum. CONCLUSION: This study showed a high risk of depression at 6 and 12 months postpartum for those who had depressive symptoms with SHI at 1 month postpartum. Our findings may contribute to the precise evaluation of depression at 6 and 12 months postpartum while considering sleep status, psychological distress and social network during pregnancy.
Antipsychotic Monotherapy vs Polytherapy for Pneumonia Risk. International-journal

Yuki Kikuchi, Hiroshi Komatsu, Hiroaki Tomita

JAMA psychiatry　2024/10/23

DOI： 10.1001/jamapsychiatry.2024.3330 　
Identification of risk loci for postpartum depression in a genome-wide association study. International-journal

Xue Li, Nagahide Takahashi, Akira Narita, Yukako Nakamura, Mika Sakurai-Yageta, Keiko Murakami, Mami Ishikuro, Taku Obara, Masahiro Kikuya, Fumihiko Ueno, Hirohito Metoki, Hisashi Ohseto, Ippei Takahashi, Tomohiro Nakamura, Noriko Warita, Tomoka Shoji, Zhiqian Yu, Chiaki Ono, Natsuko Kobayashi, Saya Kikuchi, Tasuku Matsuki, Fuji Nagami, Soichi Ogishima, Junichi Sugawara, Tetsuro Hoshiai, Masatoshi Saito, Nobuo Fuse, Kengo Kinoshita, Masayuki Yamamoto, Nobuo Yaegashi, Norio Ozaki, Gen Tamiya, Shinichi Kuriyama, Hiroaki Tomita

Psychiatry and clinical neurosciences　2024/09/17

DOI： 10.1111/pcn.13731 　

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AIM: Genome-wide association studies (GWAS) of postpartum depression (PPD) based on accumulated cohorts with multiple ethnic backgrounds have failed to identify significantly associated loci. Herein, we conducted a GWAS of Japanese perinatal women along with detailed confounding information to uncover PPD-associated loci. METHODS: The first and second cohorts (n = 9260 and n = 8582 perinatal women enrolled in the Tohoku Medical Megabank Project) and the third cohort (n = 997), recruited at Nagoya University, underwent genotyping. Of them, 1421, 1264, and 225 were classified as PPD based on the Edinburgh Postnatal Depression Scale 1 month after delivery. The most influential confounding factors of genetic liability to PPD were selected, and logistic regression analyses were performed to evaluate genetic associations with PPD after adjusting for confounders. RESULTS: A meta-analysis of GWAS results from the three cohorts identified significant associations between PPD and the following loci (P < 5 × 10-8) by integrating the number of deliveries and the number of family members living together as the most influential confounders: rs377546683 at DAB1, rs11940752 near UGT8, rs141172317, rs117928019, rs76631412, rs118131805 at DOCK2, rs188907279 near ZNF572, rs504378, rs690150, rs491868, rs689917, rs474978, rs690118, rs690253 near DIRAS2, rs1435984417 at ZNF618, rs57705782 near PTPRM, and rs185293917 near PDGFB. Pathway analyses indicated that SNPs suggestively associated with PPD were mostly over-represented in categories including long-term depression, GnRH signaling, glutamatergic synapse, oxytocin signaling, and Rap1 signaling. CONCLUSION: The current GWAS study identified eight loci significantly associated with PPD, which may clarify the genetic structure underlying its pathogenesis.
Association between exposure to atypical antipsychotics during pregnancy and risk of miscarriage. International-journal

Tomofumi Ishikawa, Takamasa Sakai, Noriyuki Iwama, Ryo Obara, Kei Morishita, Motohiko Adomi, Aoi Noda, Mami Ishikuro, Saya Kikuchi, Natsuko Kobayashi, Hiroaki Tomita, Masatoshi Saito, Hidekazu Nishigori, Shinichi Kuriyama, Nariyasu Mano, Taku Obara

Acta psychiatrica Scandinavica　2024/09/05

DOI： 10.1111/acps.13755 　

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OBJECTIVE: To evaluate the association between exposure to atypical antipsychotics during pregnancy and risk of miscarriage. MATERIAL AND METHODS: This nested case-control study used a large Japanese administrative database. Pregnancy onset and outcomes were estimated using previously reported algorithms, classifying cases as women becoming pregnant between 2013 and 2022 and ending in a miscarriage. Controls were randomly selected from the entire pregnancy cohort by risk-set sampling with replacement and were individually matched to the cases (3:1). The association between exposure to atypical antipsychotics and risk of miscarriage was assessed using conditional logistic regression adjusted for confounders. The association between benzodiazepine exposure and the risk of miscarriage was assessed as a positive control. RESULTS: In the cohort, 44,118 patients were matched with 132,317 controls. The mean ages (standard deviations) of the case and control groups were 33.3 (5.7) and 33.2 (5.5) years, respectively. The prevalence of atypical antipsychotics was 0.5% in both groups. Aripiprazole is an individual antipsychotic with the highest prescription prevalence. The adjusted odds ratios (aOR) for miscarriage were 0.966 (95% confidence interval [CI], 0.796-1.173) for atypical antipsychotics and 0.998 (0.784-1.269) for aripiprazole. A higher aOR (1.431, 95% CI 1.303-1.573) suggested an association with benzodiazepines. A sensitivity analysis that limited the population to women diagnosed with schizophrenia alone did not suggest an association between atypical antipsychotics and the risk of miscarriage. CONCLUSIONS: The results of this study do not suggest an association between exposure to atypical antipsychotics during pregnancy and the risk of miscarriage.
【-身体疾患の患者・家族のこころを支える-コンサルテーション・リエゾン精神医学】周産期医療におけるコンサルテーション・リエゾン精神医学プレコンセプションケアから育児支援まで

菊地紗耶, 小林奈津子, 富田博秋

精神医学　66　(9)　1165-1171　2024/09
Publisher: (株)医学書院
ISSN： 0488-1281

eISSN： 1882-126X
Combination of taking neuropsychiatric medications and psychological distress in pregnant women, with behavioral problems in children at 2 years of age: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Ippei Takahashi, Taku Obara, Saya Kikuchi, Natsuko Kobayashi, Ryo Obara, Aoi Noda, Minoru Ohsawa, Tomofumi Ishikawa, Nariyasu Mano, Hidekazu Nishigori, Fumihiko Ueno, Genki Shinoda, Keiko Murakami, Masatsugu Orui, Mami Ishikuro, Hiroaki Tomita, Shinichi Kuriyama

PCN reports : psychiatry and clinical neurosciences　3　(3)　e226　2024/09

DOI： 10.1002/pcn5.226 　

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AIM: To examine the association of the combination of taking neuropsychiatric medications from the onset of pregnancy to mid-pregnancy and maternal psychological distress at mid-pregnancy, with children's behavioral problems. METHODS: Neuropsychiatric medication use from the onset of pregnancy to mid-pregnancy was defined by the self-reported name of the neuropsychiatric medication in the questionnaire in early and mid-pregnancy. Maternal psychological distress was defined by the Kessler Psychological Distress Scale (K6) ≥13 on the questionnaire in mid-pregnancy. We classified the participants into four categories based on the combination of taking neuropsychiatric medications and psychological distress: "None," "Medications only," "K6 ≥ 13 only," and "Both." Children's behavioral problems were assessed using the Child Behavior Checklist for Ages 1½-5 (CBCL) at 2 years of age. The clinical ranges of the internalizing and externalizing scales of the CBCL were defined as behavioral problems. We conducted a multivariable logistic regression analysis to examine the associations between the four categories of maternal exposure and children's behavioral problems. RESULTS: Compared with the "None" category (n = 9873), the "K6 ≥ 13 only" category (n = 308) was statistically significantly associated with internalizing and externalizing problems. In contrast, the "Medications only" (n = 93) and "Both" (n = 22) categories were not statistically significantly associated with internalizing and externalizing problems, although the point estimates of the odds ratio in the "Both" category were relatively high (1.58 for the internalizing problem and 2.50 for the externalizing problem). CONCLUSION: The category of mothers taking neuropsychiatric medications and having no psychological distress during pregnancy was not associated with children's behavioral problems in the present population.
【こんなときどうする?いまさら聞けないうつ病治療における薬物療法-虎の巻-】産後うつ病における薬物療法の考え方

菊地紗耶, 小林奈津子, 富田博秋

精神科治療学　39　(8)　881-886　2024/08
Publisher: (株)星和書店
ISSN： 0912-1862
CPMSイエロー基準による頻回の血液検査が続き効果的だったクロザピンの中止を希望した治療抵抗性統合失調症の1例

佐久間篤, 五十嵐江美, 内海裕介, 菊地佑樹, 畠山拓志, 高橋雄太, 小松浩, 菊地紗耶, 富田博秋

総合病院精神医学　36　(3)　241-247　2024/07
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
Development of a simultaneous LC-MS/MS analytical method for plasma: 16 antipsychotics approved in Japan and 4 drug metabolites. International-journal

Masamitsu Maekawa, Maki Yokota, Toshihiro Sato, Yu Sato, Masaki Kumondai, Yuji Sato, Masato Suzuka, Daisuke Kobayashi, Kotaro Sakamoto, Masaki Matsuura, Masafumi Kikuchi, Hiroshi Komatsu, Kumiko Fujii, Yuji Ozeki, Hiroaki Tomita, Nariyasu Mano

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry　2024/06/25

DOI： 10.1007/s44211-024-00619-2 　

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The increased risk of adverse drug reactions due to the concomitant use of antipsychotics is problematic in the treatment of schizophrenia. Therefore, the simultaneous analysis of their plasma concentrations is required. In this study, we developed a simultaneous liquid chromatography/tandem mass spectrometry (LC-MS/MS) method for analyzing plasma antipsychotics approved in Japan for therapeutic drug monitoring (TDM) applications. First, we counted the prescriptions for 16 antipsychotics and concomitant drugs used at the Tohoku University Hospital. LC-MS/MS was used for the simultaneous analysis of 16 antipsychotics and four drug metabolites. This analysis was conducted using a combination of selected reaction monitoring mode and reversed-phase chromatography. Following the examination of the MS/MS and LC conditions, an analytical method validation test was conducted. The developed method was used to analyze plasma antipsychotic levels in patients with schizophrenia. One-third of the patients received treatment with multiple antipsychotics. Under LC-MS/MS conditions, LC separation was performed using a combination of a C18 column and ammonium formate-based mobile phases with a gradient flow. The calibration curves were optimized by adjusting the ion abundance, and 11 compounds met the criteria for intra- and inter-day reproducibility tests. Some stability test results did not meet these criteria; therefore, further investigation is required. The developed method permitted the measurement of all the plasma parameters, including concentrations above the therapeutic range. Therefore, this method may be useful in the daily TDM practice of antipsychotics.
光干渉断層計による統合失調症の網膜厚および血管密度の解析研究潜在的バイオマーカーとしての網膜

小松浩, 小野口豪, 矢花武史, 佐熊惇, 宮武博, 中澤徹, 富田博秋

精神神経学雑誌　(2024特別号)　S560-S560　2024/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
双極性障害におけるADHD特性と認知機能の直接的または抑うつ症状とレジリエンス経由での社会機能への影響

小野口豪, 小松浩, 割田紀子, 小野千晶, 堀越翔, 富田博秋

精神神経学雑誌　(2024特別号)　S397-S397　2024/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
光干渉断層計による統合失調症の網膜厚および血管密度の解析研究潜在的バイオマーカーとしての網膜

小松浩, 小野口豪, 矢花武史, 佐熊惇, 宮武博, 中澤徹, 富田博秋

精神神経学雑誌　(2024特別号)　S560-S560　2024/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
【周産期メンタルヘルスを深掘り!】精神疾患合併妊産婦の対応双極性障害(双極症)

菊地紗耶, 小林奈津子, 富田博秋

産科と婦人科　91　(6)　665-669　2024/06
Publisher: (株)診断と治療社
ISSN： 0386-9792
Obesity as a potential confounder of clozapine-induced myocarditis in the Hunter region of Australia

Yuki Kikuchi, Hiroshi Komatsu, Hiroaki Tomita

Schizophrenia Research　267　42-43　2024/05
Publisher: Elsevier BV
DOI： 10.1016/j.schres.2024.03.004 　

ISSN： 0920-9964
Availability of individual proteins for quantitative analysis in postmortem brains preserved in two different brain banks

Atsuko Nagaoka, Mizuki Hino, Ryuta Izumi, Risa Shishido, Miki Ishibashi, Masataka Hatano, Makoto Sainouchi, Akiyoshi Kakita, Hiroaki Tomita, Yasuto Kunii

Neuropsychopharmacology Reports　2024/04
Publisher: Wiley
DOI： 10.1002/npr2.12430 　

ISSN： 2574-173X

eISSN： 2574-173X

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Abstract Aim Postmortem brain research is necessary for elucidating the pathology of schizophrenia; an increasing number of studies require a combination of suitable tissue samples preserved at multiple brain banks. In this study, we examined whether a comparative study of protein expression levels can be conducted using postmortem brain samples preserved in different facilities. Methods We compared the demographic factors of postmortem brain samples preserved in two institutions and measured and compared the expression levels of glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) and glial fibrillary acidic protein (GFAP) in the prefrontal cortex and superior temporal gyrus. GAPDH is generally used as a loading control for western blotting, and GFAP is considered as an astrocyte marker in the brain. Results We found significant differences between the two institutions in postmortem interval, age at death, and preservation time. To reduce the effects of these differences on our measurements, the parameters were set as covariates in our analyses of covariance. Subsequently, no differences in GAPDH and GFAP expression were found between institutions. Conclusions When studies are conducted using brain samples preserved in different brain banks, differences in demographic factors should be carefully considered and taken into account by statistical methods to minimize their impact as much as possible. Since there was no significant difference in the protein expression levels of GAPDH and GFAP in either region between the two institutions that preserved the postmortem brains, we concluded that it is possible to perform protein quantitative analysis assuming that there is no effect of difference between two institutions.
Response to ‘Potential role of anti‐inflammatory cytokines in postpartum depression: Considerations for future research and improvement’

Chiaki T. Ono, Zhiqian Yu, Saya Kikuchi, Natsuko Kobayashi, Hiroaki Tomita

Psychiatry and Clinical Neurosciences　78　(5)　335-336　2024/03/20
Publisher: Wiley
DOI： 10.1111/pcn.13660 　

ISSN： 1323-1316

eISSN： 1440-1819
Risk Factors, Prognosis, Influence on the Offspring, and Genetic Architecture of Perinatal Depression Classified Based on the Depressive Symptom Trajectory

Hisashi Ohseto, Ippei Takahashi, Akira Narita, Taku Obara, Mami Ishikuro, Natsuko Kobayashi, Saya Kikuchi, Xue Li, Aoi Noda, Keiko Murakami, Gen Tamiya, Junichi Sugawara, Hiroaki Tomita, Shinichi Kuriyama

Depression and Anxiety　2024　1-13　2024/03/15
Publisher: Wiley
DOI： 10.1155/2024/6622666 　

ISSN： 1091-4269

eISSN： 1520-6394

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This study is aimed at revealing the risk factors, prognosis, influence on offspring, and genetic architecture of perinatal depression (PD) classified based on the depressive symptom trajectory. Pregnant women with no history of major depressive disorder (MDD) were recruited and followed up with their offspring from 1 to 5 years postpartum. Using four self-report questionnaires in the perinatal period, PD was classified into four subtypes: pregnancy, early postpartum, late postpartum, and chronic PD. Risk factors, depressive symptom trajectory from 1 to 5 years postpartum, and child behavior problems were compared among the four PD subtypes. Genome-wide association studies (GWASs) were conducted for each subtype. The relationships between the PD subtypes and polygenic risk scores (PRS) for MDD, a psychiatric disorder, and premenstrual syndrome (PMS), a hormonal disorder, were examined. Among 12,338 participants, 1,145 (9.3%) developed pregnancy PD, 856 (6.9%) developed early postpartum PD, 382 (3.1%) developed late postpartum PD, and 1,048 (8.5%) developed chronic PD. Depressive symptoms decreased to 61.0%–73.3% in the 5 years postpartum. The relationship between risk factors and PD varied based on the PD subtype. Additionally, chronic PD increased the risk of child behavior problems by 2- to 3-fold. The GWASs uncovered five significant variants in different loci depending on PD subtypes, suggesting a subtype-specific genetic architecture. The PRS for MDD was related to pregnancy, early postpartum, and chronic PD, while that for PMS was related to late postpartum PD. It was concluded that PD is heterogeneous depending on the depressive symptom trajectory. Thus, specific prevention and treatment strategies are needed.
【よくわかる! 精神疾患対応これ1冊-内科医と精神科医の連携のために】(第2部)精神科との連携が特に必要な領域児童虐待への対応

菊地紗耶, 小林奈津子, 富田博秋

診断と治療　112　(Suppl.)　61-65　2024/03
Publisher: (株)診断と治療社
ISSN： 0370-999X
Patterns of C-reactive protein trends during clozapine titration and the onset of clozapine-induced inflammation: a case series of weekly and daily C-reactive protein monitoring

Yuki Kikuchi, Hiroaki Tanifuji, Sota Ueno, Yoshifumi Onuma, Masatomo Goto, Masato Ishihara, Takeshi Toraiwa, Hiroshi Komatsu, Hiroaki Tomita

Frontiers in Psychiatry　15　2024/02/21
Publisher: Frontiers Media SA
DOI： 10.3389/fpsyt.2024.1366621 　

eISSN： 1664-0640

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Background International guidelines for clozapine titration recommend measuring C-reactive protein (CRP) weekly for 4 weeks after clozapine initiation to prevent fatal inflammatory adverse events, including myocarditis. However, limited evidence exists regarding whether weekly CRP monitoring can prevent clozapine-induced inflammation. Aims We examined the relationship between CRP trends and the development of clozapine-induced inflammation. We also explored the usefulness and limitations of CRP monitoring during clozapine titration. Method This study presents 17 and 4 cases of weekly and daily CRP monitoring during clozapine initiation, respectively. Results Among 17 patients with weekly CRP measurements, 7 had fever. Elevated CRP levels were detected before the onset of fever in two of the seven patients. Of the five remaining patients, the CRP levels on a previous test had been low; however, the fever developed suddenly. Of the 10 patients with no fever under weekly CRP monitoring, three had elevated CRP levels &gt;3.0 mg/dL. Refraining from increasing the clozapine dose may have prevented fever in these patients. Among four patients with daily CRP measurements, two became febrile. In both cases, CRP levels increased almost simultaneously with the onset of fever. Conclusion Weekly and daily CRP monitoring during clozapine titration is valuable for preventing clozapine-induced inflammation, assessing its severity, and guiding clozapine dose adjustments. Weekly CRP monitoring may not adequately predict clozapine-induced inflammation in some cases. Consequently, clinicians should be aware of the sudden onset of clozapine-induced inflammation, even if CRP levels are low. Daily CRP monitoring is better for detecting clozapine-induced inflammation.
Effect of concomitant use of valproic acid during clozapine initiation on clozapine-induced inflammation among Japanese patients with schizophrenia

Yuki Kikuchi, Hiroshi Komatsu, Yuji Otsuka, Fumiaki Ito, Yuji Yada, Hiroaki Tanifuji, Hiroaki Tomita

Psychiatry Research　115810-115810　2024/02
Publisher: Elsevier BV
DOI： 10.1016/j.psychres.2024.115810 　

ISSN： 0165-1781
Marked alteration of phosphoinositide signaling‐associated molecules in postmortem prefrontal cortex with bipolar disorder

Mizuki Hino, Yasuto Kunii, Risa Shishido, Atsuko Nagaoka, Junya Matsumoto, Hiroyasu Akatsu, Yoshio Hashizume, Hideki Hayashi, Akiyoshi Kakita, Hiroaki Tomita, Hirooki Yabe

Neuropsychopharmacology Reports　2024/01/22
Publisher: Wiley
DOI： 10.1002/npr2.12409 　

ISSN： 2574-173X

eISSN： 2574-173X

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Abstract Aim The etiology of bipolar disorder (BD) remains unknown; however, lipid abnormalities in BD have received increasing attention in recent years. In this study, we examined the expression levels of enzyme proteins associated with the metabolic pathway of phosphoinositides (PIs) and their downstream effectors, protein kinase B (Akt1) and glycogen synthase kinase 3β (GSK3β), which have been assumed to be the targets of mood stabilizers such as lithium, in the postmortem brains of patients with BD. Methods The protein expression levels of phosphatidylinositol 4‐phosphate 5‐kinase type‐1 gamma (PIP5K1C), phosphatidylinositol 4‐kinase alpha (PIK4CA), phosphatase and tensin homolog deleted from chromosome 10 (PTEN), Akt1, and GSK3β were measured using enzyme‐linked immunosorbent assays and multiplex fluorescent bead‐based immunoassays in the prefrontal cortex (PFC). Specifically, PTEN, Akt1, GSK3β, and PIP5K1C were measured in seven BD patients and 48 controls. Additionally, PIK4CA was analyzed in 10 cases and 34 controls. Results PTEN expression levels were markedly decreased in the PFCs of patients with BD, whereas those of Akt and GSK3β were prominently elevated. Moreover, patients medicated with lithium exhibited higher Akt1 expression levels and lower PTEN expression levels in comparison with the untreated group. Conclusion Our results suggest that the expression levels of Akt1/GSK3β and its upstream regulator PTEN are considerably altered.
Concomitant Use of Clozapine and Suvorexant Doubled Clozapine Plasma Levels: A Case Report. International-journal

Yuki Kikuchi, Toshihiro Sato, Keiichi Murakami, Tatsui Otsuka, Terufumi Machida, Keigo Yoshikawa, Yoshiaki Shiozawa, Hiroshi Komatsu, Masamitsu Maekawa, Nariyasu Mano, Hiroaki Tomita

Journal of clinical psychopharmacology　2024/01/16

DOI： 10.1097/JCP.0000000000001808 　
クロザピン血中濃度変動と薬物動態関連因子の一塩基多型の関連解析

佐藤紀宏, 公文代將希, 林和未, 小野口豪, 小松浩, 平塚真弘, 前川正充, 富田博秋, 眞野成康

日本臨床薬理学会学術総会抄録集　44回　1-5　2024/01
Publisher: (一社)日本臨床薬理学会
eISSN： 2436-5580
Live two‐way video versus <scp>face‐to‐face</scp> treatment for depression, anxiety, and <scp>obsessive‐compulsive</scp> disorder: A <scp>24‐week</scp> randomized controlled trial

Taishiro Kishimoto, Shotaro Kinoshita, Momoko Kitazawa, Akitoyo Hishimoto, Takeshi Asami, Akira Suda, Shogyoku Bun, Toshiaki Kikuchi, Mitsuhiro Sado, Akihiro Takamiya, Masaru Mimura, Yasunori Sato, Ryo Takemura, Kengo Nagashima, Takashi Nakamae, Yoshinari Abe, Tetsufumi Kanazawa, Yasuo Kawabata, Hiroaki Tomita, Koichi Abe, Seiji Hongo, Hiroshi Kimura, Aiko Sato, Hisashi Kida, Kei Sakuma, Michitaka Funayama, Naoya Sugiyama, Kousuke Hino, Toru Amagai, Maki Takamiya, Hideyuki Kodama, Kenichi Goto, Shuichiro Fujiwara, Hisanobu Kaiya, Kiichiro Nagao

Psychiatry and Clinical Neurosciences　2023/12/15
Publisher: Wiley
DOI： 10.1111/pcn.13618 　

ISSN： 1323-1316

eISSN： 1440-1819

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Aim Live two‐way video, easily accessible from home via smartphones and other devices, is becoming a new way of providing psychiatric treatment. However, lack of evidence for real‐world clinical setting effectiveness hampers its approval by medical insurance in some countries. Here, we conducted the first large‐scale pragmatic, randomized controlled trial to determine the effectiveness of long‐term treatment for multiple psychiatric disorders via two‐way video using smartphones and other devices, which are currently the primary means of telecommunication. Methods This randomized controlled trial compared two‐way video versus face‐to‐face treatment for depressive disorder, anxiety disorder, and obsessive‐compulsive disorder in the subacute/maintenance phase during a 24‐week period. Adult patients with the above‐mentioned disorders were allocated to either a two‐way video group (≥50% video sessions) or a face‐to‐face group (100% in‐person sessions) and received standard treatment covered by public medical insurance. The primary outcome was the 36‐Item Short‐Form Health Survey Mental Component Summary (SF‐36 MCS) score. Secondary outcomes included all‐cause discontinuation, working alliance, adverse events, and the severity rating scales for each disorder. Results A total of 199 patients participated in this study. After 24 weeks of treatment, two‐way video treatment was found to be noninferior to face‐to‐face treatment regarding SF‐36 MCS score (48.50 vs 46.68, respectively; p < 0.001). There were no significant differences between the groups regarding most secondary end points, including all‐cause discontinuation, treatment efficacy, and satisfaction. Conclusion Two‐way video treatment using smartphones and other devices, was noninferior to face‐to‐face treatment in real‐world clinical settings. Modern telemedicine, easily accessible from home, can be used as a form of health care.
Retina as a potential biomarker in schizophrenia spectrum disorders: a systematic review and meta-analysis of optical coherence tomography and electroretinography

Hiroshi Komatsu, Goh Onoguchi, Steven M. Silverstein, Stefan Jerotic, Atsushi Sakuma, Nobuhisa Kanahara, Yoshihisa Kakuto, Takashi Ono, Takeshi Yabana, Toru Nakazawa, Hiroaki Tomita

Molecular Psychiatry　2023/12/11
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s41380-023-02340-4 　

ISSN： 1359-4184

eISSN： 1476-5578

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Abstract Introduction Abnormal findings on optical coherence tomography (OCT) and electroretinography (ERG) have been reported in participants with schizophrenia spectrum disorders (SSDs). This study aims to reveal the pooled standard mean difference (SMD) in retinal parameters on OCT and ERG among participants with SSDs and healthy controls and their association with demographic characteristics, clinical symptoms, smoking, diabetes mellitus, and hypertension. Methods Using PubMed, Scopus, Web of Science, and PSYNDEX, we searched the literature from inception to March 31, 2023, using specific search terms. This study was registered with PROSPERO (CRD4202235795) and conducted according to PRISMA 2020. Results We included 65 studies in the systematic review and 44 in the meta-analysis. Participants with SSDs showed thinning of the peripapillary retinal nerve fiber layer (pRNFL), macular ganglion cell layer- inner plexiform cell layer, and retinal thickness in all other segments of the macula. A meta-analysis of studies that excluded SSD participants with diabetes and hypertension showed no change in results, except for pRNFL inferior and nasal thickness. Furthermore, a significant difference was found in the pooled SMD of pRNFL temporal thickness between the left and right eyes. Meta-regression analysis revealed an association between retinal thinning and duration of illness, positive and negative symptoms. In OCT angiography, no differences were found in the foveal avascular zone and superficial layer foveal vessel density between SSD participants and controls. In flash ERG, the meta-analysis showed reduced amplitude of both a- and b-waves under photopic and scotopic conditions in SSD participants. Furthermore, the latency of photopic a-wave was significantly shorter in SSD participants in comparison with HCs. Discussion Considering the prior report of retinal thinning in unaffected first-degree relatives and the results of the meta-analysis, the findings suggest that retinal changes in SSDs have both trait and state aspects. Future longitudinal multimodal retinal imaging studies are needed to clarify the pathophysiological mechanisms of these changes and to clarify their utility in individual patient monitoring efforts.
Slower clozapine titration is associated with delayed onset of clozapine-induced fever among Japanese patients with schizophrenia

Yuki Kikuchi, Yuji Yada, Yuji Otsuka, Fumiaki Ito, Hiroaki Tanifuji, Hiroshi Komatsu, Hiroaki Tomita

Schizophrenia　9　(1)　2023/11/20
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s41537-023-00412-6 　

eISSN： 2754-6993

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Abstract Clozapine-induced fever marks the beginning of its inflammatory and potentially life-threatening adverse effects, such as myocarditis. We retrospectively analyzed the correlation between clozapine titration rate and fever onset date in 254 Japanese patients, including 55 with treatment-resistant schizophrenia who developed clozapine-induced fever. Pearson’s product-moment correlation indicated a significant delay in the fever onset date with slower titration. Most fever onset cases occurred within 4 weeks, even with slow titration. Therefore, clinicians should remain vigilant in monitoring clozapine-induced fever within 4 weeks of clozapine initiation, regardless of the titration rate.
総合病院における産科と精神科の連携:妊産婦のメンタルヘルスと精神病患者の出産のために周産期における精神科薬物療法と共同意思決定東北大学病院における実践報告

菊地紗耶, 小林奈津子, 木村涼子, 岩渕賢嗣, 富田博秋

総合病院精神医学　35　(Suppl.)　S-97　2023/11
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
妊娠中の睡眠に関する主観的評価の変化と産後うつ病リスクの関連性

木村涼子, 菊地紗耶, 小林奈津子, 小野千晶, 割田紀子, 富田博秋

総合病院精神医学　35　(Suppl.)　S-162　2023/11
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
ペリネイタルロスに伴うメンタルヘルス上の問題と心理社会的要因に関する後方視調査

岩渕賢嗣, 菊地紗耶, 小林奈津子, 木村涼子, 富田博秋

総合病院精神医学　35　(Suppl.)　S-194　2023/11
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
自殺企図を契機にレビー小体型認知症が疑われECTを施行した双極性障害の1例

佐々木茜, 高柳義哉, 小番健矢, 冨本和歩, 佐久間篤, 菊地紗耶, 小松浩, 富田博秋

総合病院精神医学　35　(Suppl.)　S-252　2023/11
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
東日本大震災被災地域の子どものメンタルヘルスと学校における集団活動の関連について

松木佑, 吉田弘和, 北川佳奈, 遠藤愛子, 小林奈津子, 菊地紗耶, 本多奈美, 大塚達以, 富田博秋

日本児童青年精神医学会総会抄録集　64回　O17-3　2023/11
Publisher: (一社)日本児童青年精神医学会
精神疾患ブレインバンクにおける生前登録時の自殺予防と自殺脳研究の取り組み

長岡敦子, 旗野将貴, 細貝優人, 宍戸理紗, 日野瑞城, 三浦至, 國井泰人, 富田博秋

総合病院精神医学　35　(Suppl.)　S-212　2023/11
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
東北大学病院精神科を拠点としたクロザピン療法,ECT,rTMS療法の地域連携体制の構築

小松浩, 小野口豪, 富田博秋

総合病院精神医学　35　(Suppl.)　S-155　2023/11
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
自殺企図を契機にレビー小体型認知症が疑われECTを施行した双極性障害の1例

佐々木茜, 高柳義哉, 小番健矢, 冨本和歩, 佐久間篤, 菊地紗耶, 小松浩, 富田博秋

総合病院精神医学　35　(Suppl.)　S-252　2023/11
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
薬剤性イレウスをきたした治療抵抗性双極I型障害に対し維持ECTが有効であった一例

小番健矢, 小松浩, 小林奈津子, 冨本和歩, 佐久間篤, 富田博秋

総合病院精神医学　35　(Suppl.)　S-254　2023/11
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
産後早期の睡眠に関する主観的評価の変化と産後うつ病リスクの関連性

木村涼子, 菊地紗耶, 小林奈津子, 小野千晶, 割田紀子, 富田博秋

日本周産期メンタルヘルス学会学術集会抄録集　19回　112-112　2023/10
Publisher: 日本周産期メンタルヘルス学会
向精神薬服用中の母乳育児の実態と児への影響授乳プランシートの結果から

菊地紗耶, 小林奈津子, 小原拓, 岩渕理子, 齋藤昌利, 木村涼子, 岩渕賢嗣, 富田博秋

日本周産期メンタルヘルス学会学術集会抄録集　19回　114-114　2023/10
Publisher: 日本周産期メンタルヘルス学会
Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1 expression in the postmortem brain and responsiveness to antipsychotics

Kazusa Miyahara, Mizuki Hino, Risa Shishido, Ryuta Izumi, Atsuko Nagaoka, Hideki Hayashi, Akiyoshi Kakita, Hirooki Yabe, Hiroaki Tomita, Yasuto Kunii

Journal of Psychiatric Research　166　10-16　2023/10
Publisher: Elsevier BV
DOI： 10.1016/j.jpsychires.2023.08.007 　

ISSN： 0022-3956
Editorial: Molecular pathology in psychiatric diseases: frontiers of postmortem brain research

Yasuto Kunii, Mizuki Hino, Hiroaki Tomita

Frontiers in Psychiatry　14　2023/09/27
Publisher: Frontiers Media SA
DOI： 10.3389/fpsyt.2023.1286182 　

eISSN： 1664-0640
Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background.

Makiko Taira, Shunji Mugikura, Naoko Mori, Atsushi Hozawa, Tomo Saito, Tomohiro Nakamura, Hideyasu Kiyomoto, Tadao Kobayashi, Soichi Ogishima, Fuji Nagami, Akira Uruno, Ritsuko Shimizu, Tomoko Kobayashi, Jun Yasuda, Shigeo Kure, Miyuki Sakurai, Ikuko N Motoike, Kazuki Kumada, Naoki Nakaya, Taku Obara, Kentaro Oba, Atsushi Sekiguchi, Benjamin Thyreau, Tatsushi Mutoh, Yuji Takano, Mitsunari Abe, Norihide Maikusa, Yasuko Tatewaki, Yasuyuki Taki, Nobuo Yaegashi, Hiroaki Tomita, Kengo Kinoshita, Shinichi Kuriyama, Nobuo Fuse, Masayuki Yamamoto

JMA journal　6　(3)　246-264　2023/07/14

DOI： 10.31662/jmaj.2022-0220 　

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The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study (TMM Brain MRI Study) was established to collect multimodal information through neuroimaging and neuropsychological assessments to evaluate the cognitive function and mental health of residents who experienced the Great East Japan Earthquake (GEJE) and associated tsunami. The study also aimed to promote advances in personalized healthcare and medicine related to mental health and cognitive function among the general population. We recruited participants for the first (baseline) survey starting in July 2014, enrolling individuals who were participating in either the TMM Community-Based Cohort Study (TMM CommCohort Study) or the TMM Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). We collected multiple magnetic resonance imaging (MRI) sequences, including 3D T1-weighted sequences, magnetic resonance angiography (MRA), diffusion tensor imaging (DTI), pseudo-continuous arterial spin labeling (pCASL), and three-dimensional fluid-attenuated inversion recovery (FLAIR) sequences. To assess neuropsychological status, we used both questionnaire- and interview-based rating scales. The former assessments included the Tri-axial Coping Scale, Impact of Event Scale in Japanese, Profile of Mood States, and 15-item Depression, Anxiety, and Stress Scale, whereas the latter assessments included the Mini-Mental State Examination, Japanese version. A total of 12,164 individuals were recruited for the first (baseline) survey, including those unable to complete all assessments. In parallel, we returned the MRI results to the participants and subsequently shared the MRI data through the TMM Biobank. At present, the second (first follow-up) survey of the study started in October 2019 is underway. In this study, we established a large and comprehensive database that included robust neuroimaging data as well as psychological and cognitive assessment data. In combination with genomic and omics data already contained in the TMM Biobank database, these data could provide new insights into the relationships of pathological processes with neuropsychological disorders, including age-related cognitive impairment.
The influence of tissue pH and RNA integrity number on gene expression of human postmortem brain

Kazusa Miyahara, Mizuki Hino, Zhiqian Yu, Chiaki Ono, Atsuko Nagaoka, Masataka Hatano, Risa Shishido, Hirooki Yabe, Hiroaki Tomita, Yasuto Kunii

Frontiers in Psychiatry　14　2023/07/14
Publisher: Frontiers Media SA
DOI： 10.3389/fpsyt.2023.1156524 　

eISSN： 1664-0640

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Background Evaluating and controlling confounders are necessary when investigating molecular pathogenesis using human postmortem brain tissue. Particularly, tissue pH and RNA integrity number (RIN) are valuable indicators for controlling confounders. However, the influences of these indicators on the expression of each gene in postmortem brain have not been fully investigated. Therefore, we aimed to assess these effects on gene expressions of human brain samples. Methods We isolated total RNA from occipital lobes of 13 patients with schizophrenia and measured the RIN and tissue pH. Gene expression was analyzed and gene sets affected by tissue pH and RIN were identified. Moreover, we examined the functions of these genes by enrichment analysis and upstream regulator analysis. Results We identified 2,043 genes (24.7%) whose expressions were highly correlated with pH; 3,004 genes (36.3%) whose expressions were highly correlated with RIN; and 1,293 genes (15.6%) whose expressions were highly correlated with both pH and RIN. Genes commonly affected by tissue pH and RIN were highly associated with energy production and the immune system. In addition, genes uniquely affected by tissue pH were highly associated with the cell cycle, whereas those uniquely affected by RIN were highly associated with RNA processing. Conclusion The current study elucidated the influence of pH and RIN on gene expression profiling and identified gene sets whose expressions were affected by tissue pH or RIN. These findings would be helpful in the control of confounders for future postmortem brain studies.
Polydipsia and autistic traits in patients with schizophrenia spectrum disorders

Hiroshi Komatsu, Takashi Ono, Yuji Onouchi, Goh Onoguchi, Yoshinori Maita, Yusuke Ishida, Takahiro Maki, Akiko Oba, Hiroaki Tomita, Yoshihisa Kakuto

Frontiers in Psychiatry　14　2023/07/06
Publisher: Frontiers Media SA
DOI： 10.3389/fpsyt.2023.1205138 　

eISSN： 1664-0640

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Introduction Polydipsia, prevalent in 6%–20% of patients with schizophrenia, results in seclusion and prolonged hospitalization. It is also observed in autistic individuals, with previous studies reporting that autism accounted for 20% of all hospitalized patients with polydipsia. The current study investigated the association between polydipsia and autistic traits in patients with schizophrenia spectrum disorders (SSDs) based on the hypothesis that higher autistic traits would be observed in schizophrenic patients with polydipsia. Methods In the first study (study A), the autism-spectrum quotient [(AQ); Japanese version] scores of long-stay inpatients with and without polydipsia were compared. Furthermore, the association between polydipsia and autistic traits was also examined in short-stay inpatients and outpatients with SSDs (study B). Results Study A showed that patients with polydipsia scored significantly higher on the three AQ subscales (attention switching; communication; and imagination) compared to those without. Study B also showed that patients with polydipsia had significantly higher AQ scores overall and for several subscales compared to those without polydipsia. Binary logistic regression analysis of the combined sample showed that male gender and higher autistic traits were significant predictors of polydipsia. Discussion The study highlights the importance of focusing on such traits to understand the pathogenesis of polydipsia in SSD patients.
On the Mental Health Needs Under the Russian Invasion in Ternopil, Ukraine: A Preliminary Report on the Provision of Mental Health Service

Mizuki Hino, Yasuto Kunii, Bogdan I. Gerashchenko, Yumiko Hamaie, Shinichi Egawa, Shinichi Kuriyama, Oksana O. Shevchuk, Mykhaylo M. Korda, Olena P. Venher, Hiroaki Tomita

Annals of Global Health　89　(1)　2023/06/08
Publisher: Ubiquity Press, Ltd.
DOI： 10.5334/aogh.4076 　

ISSN： 2214-9996
Comprehensive evaluation of machine learning algorithms for predicting sleep–wake conditions and differentiating between the wake conditions before and after sleep during pregnancy based on heart rate variability

Xue Li, Chiaki Ono, Noriko Warita, Tomoka Shoji, Takashi Nakagawa, Hitomi Usukura, Zhiqian Yu, Yuta Takahashi, Kei Ichiji, Norihiro Sugita, Natsuko Kobayashi, Saya Kikuchi, Ryoko Kimura, Yumiko Hamaie, Mizuki Hino, Yasuto Kunii, Keiko Murakami, Mami Ishikuro, Taku Obara, Tomohiro Nakamura, Fuji Nagami, Takako Takai, Soichi Ogishima, Junichi Sugawara, Tetsuro Hoshiai, Masatoshi Saito, Gen Tamiya, Nobuo Fuse, Susumu Fujii, Masaharu Nakayama, Shinichi Kuriyama, Masayuki Yamamoto, Nobuo Yaegashi, Noriyasu Homma, Hiroaki Tomita

Frontiers in Psychiatry　14　2023/06/06
Publisher: Frontiers Media SA
DOI： 10.3389/fpsyt.2023.1104222 　

eISSN： 1664-0640

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Introduction Perinatal women tend to have difficulties with sleep along with autonomic characteristics. This study aimed to identify a machine learning algorithm capable of achieving high accuracy in predicting sleep–wake conditions and differentiating between the wake conditions before and after sleep during pregnancy based on heart rate variability (HRV). Methods Nine HRV indicators (features) and sleep–wake conditions of 154 pregnant women were measured for 1 week, from the 23rd to the 32nd weeks of pregnancy. Ten machine learning and three deep learning methods were applied to predict three types of sleep–wake conditions (wake, shallow sleep, and deep sleep). In addition, the prediction of four conditions, in which the wake conditions before and after sleep were differentiated—shallow sleep, deep sleep, and the two types of wake conditions—was also tested. Results and Discussion In the test for predicting three types of sleep–wake conditions, most of the algorithms, except for Naïve Bayes, showed higher areas under the curve (AUCs; 0.82–0.88) and accuracy (0.78–0.81). The test using four types of sleep–wake conditions with differentiation between the wake conditions before and after sleep also resulted in successful prediction by the gated recurrent unit with the highest AUC (0.86) and accuracy (0.79). Among the nine features, seven made major contributions to predicting sleep–wake conditions. Among the seven features, “the number of interval differences of successive RR intervals greater than 50 ms (NN50)” and “the proportion dividing NN50 by the total number of RR intervals (pNN50)” were useful to predict sleep–wake conditions unique to pregnancy. These findings suggest alterations in the vagal tone system specific to pregnancy.
Maternal social isolation in the perinatal period and early childhood development: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Keiko Murakami, Aoi Noda, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Tomomi Onuma, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Social psychiatry and psychiatric epidemiology　58　(11)　1593-1601　2023/06/03

DOI： 10.1007/s00127-023-02498-w 　

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PURPOSE: Studies examining the associations between maternal social relationships and early childhood development have mainly focused on social relationships after childbirth. We aimed to prospectively examine the associations between the transition of maternal social isolation from the prenatal to postnatal period and early childhood development. METHODS: We analyzed data for 6692 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Social isolation in the prenatal and postnatal periods was assessed by the Lubben Social Network Scale-abbreviated version and categorized into four groups: none, prenatal only, postnatal only, and both. The Ages and Stages Questionnaire, Third Edition, which consists of five developmental areas, was used to assess developmental delays in children at 2 and 3.5 years of age. Multiple logistic regression analyses were conducted to examine the associations between maternal social isolation and developmental delays. RESULTS: The prevalence of social isolation in both the prenatal and postnatal periods was 13.1%. Social isolation in both the prenatal and postnatal periods was associated with developmental delays in children at 2 and 3.5 years of age: the multivariate-adjusted odds ratios (95% confidence intervals) were 1.68 (1.39-2.04) and 1.43 (1.17-1.76), respectively. Social isolation in the prenatal period only and social isolation in the postnatal period only were not associated with developmental delays in children at 2 and 3.5 years of age. CONCLUSION: Maternal social isolation in both the prenatal and postnatal periods was associated with an increased risk of developmental delays in early childhood.
緩和ケア×リエゾンチーム～精神疾患のある患者を支える～東北大学病院における緩和ケアチームと精神科リエゾンチームの連携

五十嵐江美, 中條康子, 田上恵太, 鴇田百合子, 内海裕介, 佐久間篤, 井上彰, 富田博秋

Palliative Care Research　18　(Suppl.)　S99-S99　2023/06
Publisher: (NPO)日本緩和医療学会
eISSN： 1880-5302
ウクライナ侵攻に関するメンタルヘルス上の諸課題ロシア侵攻下のウクライナにおけるメンタルヘルスの実態

國井泰人, 藤井進, 日野瑞城, 濱家由美子, 野中小百合, 江川新一, 栗山進一, 富田博秋

精神神経学雑誌　(2023特別号)　S310-S310　2023/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
妊婦における精神神経用剤服薬および心理的苦痛の有無と2歳時点の児の行動特性との関連

高橋一平, 小原拓, 菊地紗耶, 小林奈津子, 小原竜, 野田あおい, 上野史彦, 大沼ともみ, 村上慶子, 石黒真美, 富田博秋, 栗山進一

精神神経学雑誌　(2023特別号)　S584-S584　2023/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
白血球数4000/μL未満による頻回の血液検査が続きクロザピン中止を希望した治療抵抗性統合失調症の一例

佐久間篤, 五十嵐江美, 内海裕介, 菊地佑樹, 畠山拓志, 高橋雄太, 小松浩, 菊地紗耶, 富田博秋

精神神経学雑誌　(2023特別号)　S695-S695　2023/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
長期入院中の統合失調症患者のself-stigmaに関わる臨床要因に関する予備的検討

尾之内勇治, 小松浩, 大野高志, 富田博秋, 角藤芳久

精神神経学雑誌　(2023特別号)　S395-S395　2023/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
統合失調症スペクトラム障害における網膜異常と精神症状の重症度との関連性メタ解析による知見

小松浩, 小野口豪, 矢花武史, 富田博秋

精神神経学雑誌　(2023特別号)　S405-S405　2023/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
クロザピン誘発性の薬剤性肺炎による投与中止後に、緩徐増量によりクロザピン再投与に成功した一例

菊地佑樹, 小松浩, 佐久間篤, 谷藤弘淳, 富田博秋

精神神経学雑誌　(2023特別号)　S410-S410　2023/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
New long-stay患者における自閉性特性と多飲症との関連についての調査

小松浩, 大野高志, 尾之内勇治, 小野口豪, 米田芳則, 富田博秋, 角藤芳久

精神神経学雑誌　(2023特別号)　S580-S580　2023/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
統合失調症における自閉性と自閉スペクトラム症-病態における同異の研究を臨床に活かす知見- 統合失調症の自閉症的特性に関連するバイオマーカー研究の取り組み

小松浩, 小野口豪, 富田博秋

精神神経学雑誌　(2023特別号)　S624-S624　2023/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
白血球数4000/μL未満による頻回の血液検査が続きクロザピン中止を希望した治療抵抗性統合失調症の一例

佐久間篤, 五十嵐江美, 内海裕介, 菊地佑樹, 畠山拓志, 高橋雄太, 小松浩, 菊地紗耶, 富田博秋

精神神経学雑誌　(2023特別号)　S695-S695　2023/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
Slower clozapine titration than the official Japanese protocol led to fewer inflammatory adverse effects: A retrospective chart review of seven hospitals

Yuki Kikuchi, Hiroshi Komatsu, Yuji Otsuka, Fumiaki Ito, Nobuhisa Kanahara, Hiroaki Tanifuji, Hiroaki Tomita

Schizophrenia Research　2023/06
Publisher: Elsevier BV
DOI： 10.1016/j.schres.2023.06.003 　

ISSN： 0920-9964
Association between low levels of anti-inflammatory cytokines during pregnancy and postpartum depression. International-journal

Chiaki T Ono, Zhiqian Yu, Taku Obara, Mami Ishikuro, Keiko Murakami, Masahiro Kikuya, Saya Kikuchi, Natsuko Kobayashi, Hisaaki Kudo, Soichi Ogishima, Naoko Minegishi, Junichi Sugawara, Shinichi Kuriyama, Masayuki Yamamoto, Nobuo Yaegashi, Hiroaki Tomita

Psychiatry and clinical neurosciences　77　(8)　434-441　2023/05/13

DOI： 10.1111/pcn.13566 　

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AIM: Previous studies based on a relatively limited number of subjects have indicated potential associations between plasma cytokine concentrations in perinatal women and postpartum depression (PPD). This report aimed to examine alterations in cytokine levels during pregnancy and after delivery by measuring nine cytokines in prenatal and postnatal plasma samples in a large cohort. METHODS: A nested, case-control study was conducted using plasma samples from 247 women with PPD (Edinburgh Postnatal Depression Scale: EPDS ≥9) and 243 age-matched control (EPDS ≤2) women from among perinatal women who participated in the Tohoku Medical Megabank three-generation cohort. Concentrations of nine plasma cytokines (IFN-γ, IL-1β, IL-4, IL-6, IL-10, IL-12p40, IL-12p70, IL-13, and TNF-α) in plasma collected at the time of enrollment during pregnancy and one month after delivery were determined using an immunoassay kit. RESULTS: Cross-sectional comparisons of cytokine levels during pregnancy and after delivery indicated that the PPD group maintained significantly lower plasma IL-4 levels during pregnancy and after delivery than the control group, and that plasma IL-4 levels decreased significantly during pregnancy regardless of PPD status. Plasma IL-10 levels were significantly higher during pregnancy than after delivery only among healthy controls, and plasma IL-10 levels were significantly higher in the control group than in the PPD group. Moreover, IFN-γ, IL-6, IL-12p40, and TNF-α levels were significantly lower during pregnancy compared with after delivery regardless of PPD status. CONCLUSIONS AND RELEVANCE: These results suggest a potential protective effect of the anti-inflammatory cytokines IL-4 and IL-10 during pregnancy against the development of PPD. This article is protected by copyright. All rights reserved.
Identification of schizophrenia symptom-related gene modules by postmortem brain transcriptome analysis. International-journal

Kazusa Miyahara, Mizuki Hino, Risa Shishido, Atsuko Nagaoka, Ryuta Izumi, Hideki Hayashi, Akiyoshi Kakita, Hirooki Yabe, Hiroaki Tomita, Yasuto Kunii

Translational psychiatry　13　(1)　144-144　2023/05/04

DOI： 10.1038/s41398-023-02449-8 　

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Schizophrenia is a multifactorial disorder, the genetic architecture of which remains unclear. Although many studies have examined the etiology of schizophrenia, the gene sets that contribute to its symptoms have not been fully investigated. In this study, we aimed to identify each gene set associated with corresponding symptoms of schizophrenia using the postmortem brains of 26 patients with schizophrenia and 51 controls. We classified genes expressed in the prefrontal cortex (analyzed by RNA-seq) into several modules by weighted gene co-expression network analysis (WGCNA) and examined the correlation between module expression and clinical characteristics. In addition, we calculated the polygenic risk score (PRS) for schizophrenia from Japanese genome-wide association studies, and investigated the association between the identified gene modules and PRS to evaluate whether genetic background affected gene expression. Finally, we conducted pathway analysis and upstream analysis using Ingenuity Pathway Analysis to clarify the functions and upstream regulators of symptom-related gene modules. As a result, three gene modules generated by WGCNA were significantly correlated with clinical characteristics, and one of these showed a significant association with PRS. Genes belonging to the transcriptional module associated with PRS significantly overlapped with signaling pathways of multiple sclerosis, neuroinflammation, and opioid use, suggesting that these pathways may also be profoundly implicated in schizophrenia. Upstream analysis indicated that genes in the detected module were profoundly regulated by lipopolysaccharides and CREB. This study identified schizophrenia symptom-related gene sets and their upstream regulators, revealing aspects of the pathophysiology of schizophrenia and identifying potential therapeutic targets.
Correction: Retinal layers and associated clinical factors in schizophrenia spectrum disorders: a systematic review and meta-analysis (Molecular Psychiatry, (2022), 27, 9, (3592-3616), 10.1038/s41380-022-01591-x)

Hiroshi Komatsu, Goh Onoguchi, Stefan Jerotic, Nobuhisa Kanahara, Yoshihisa Kakuto, Takashi Ono, Shunichi Funakoshi, Takeshi Yabana, Toru Nakazawa, Hiroaki Tomita

Molecular Psychiatry　28　(5)　2170　2023/05

DOI： 10.1038/s41380-023-01983-7 　

ISSN： 1359-4184

eISSN： 1476-5578
Association between maternal psychological distress and children's neurodevelopment in offspring aged 4 years in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Ippei Takahashi, Taku Obara, Saya Kikuchi, Mika Kobayashi, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Shigeo Kure, Nobuo Yaegashi, Shinichi Kuriyama

Journal of paediatrics and child health　59　(3)　548-554　2023/05

DOI： 10.1111/jpc.16353 　

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AIM: An association between maternal psychological distress and children's development has been reported, but reports from Japan are limited. This study aimed to examine the association of maternal psychological distress with children's neurodevelopment in Japan. METHODS: The study assessed data of 7646 mother-infant pairs in the Japanese population. We used Kessler Psychological Distress Scale, a screening tool for psychological distress, to assess maternal psychological distress in early pregnancy and 2 years postpartum and divided it into four categories: none in both the pre-natal and post-natal periods, only the pre-natal period, only the post-natal period and both the pre-natal and post-natal periods. Children's neurodevelopment was assessed using the Ages & Stages Questionnaires Third Edition (ASQ-3) at 4 years of age. ASQ-3 comprises five domains (communication, gross motor, fine motor, problem solving and personal-social), and the score of less than -2 standard deviation relative to the mean in reference was defined as having developmental delay. We conducted multivariate logistic regression analysis to examine the association between maternal psychological distress and children's neurodevelopment. RESULTS: The prevalence of developmental delay of communication, gross motor, fine motor, problem solving and personal-social were 4.0%, 4.3%, 4.9%, 3.8% and 4.6%, respectively. Maternal psychological distress in only the postpartum period and both pre-natal and postpartum periods were associated with risks of developmental delay in all domains. Maternal psychological distress in only the pre-natal period was associated with developmental delay in communication. CONCLUSIONS: Maternal psychological distress is associated with risks of children's developmental delay.
【プレコンセプションケアからみた精神医学-妊娠・出産に向けたメンタルヘルスの新たな潮流-】うつ病・不安症のプレコンセプションケア

菊地紗耶, 小林奈津子, 木村涼子, 富田博秋

精神科治療学　38　(5)　549-554　2023/05
Publisher: (株)星和書店
ISSN： 0912-1862
10年間のコホート調査に基づく東日本大震災被災者における心理的苦痛の経年変化 Peer-reviewed

臼倉瞳, 内海裕介, 瀬戸萌, 佐久間篤, 菅原由美, 國井泰人, 中谷直樹, 寳澤篤, 辻一郎, 富田博秋

精神神経学雑誌　125　(4)　266-274　2023/04/25

DOI： 10.57369/pnj.23-039 　
特集わが国の若手による統合失調症研究最前線死後脳を用いた統合失調症研究

國井泰人, 日野瑞城, 富田博秋

精神医学　65　(4)　417-424　2023/04/15
Publisher: 株式会社医学書院
DOI： 10.11477/mf.1405206889 　

ISSN： 0488-1281

eISSN： 1882-126X
【統合失調症診療のフロントライン Part 1】クロザピンの作用機序

國井泰人, 日野瑞城, 富田博秋

臨床精神医学　52　(4)　425-432　2023/04
Publisher: (株)アークメディア
ISSN： 0300-032X
【わが国の若手による統合失調症研究最前線】死後脳を用いた統合失調症研究

國井泰人, 日野瑞城, 富田博秋

精神医学　65　(4)　417-424　2023/04
Publisher: (株)医学書院
ISSN： 0488-1281

eISSN： 1882-126X
【こんな時どうする? 5W2Hで学ぶ抗うつ薬の使い方】5W2Hで学ぶ抗うつ薬の使い方妊娠・授乳期

菊地紗耶, 小林奈津子, 木村涼子, 富田博秋

薬事　65　(5)　903-907　2023/04
Publisher: (株)じほう
ISSN： 0016-5980
Maternal social isolation and behavioral problems in preschool children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Ippei Takahashi, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

European child & adolescent psychiatry　2023/03/30

DOI： 10.1007/s00787-023-02199-4 　

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It is essential to clarify factors associated with mental health and behavioral problems in early childhood, because children are critical stages of life for mental health. We aimed to prospectively examine the associations between maternal social isolation and behavioral problems in preschool children. We analyzed data from 5842 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. The Lubben Social Network Scale-abbreviated version was used to assess social isolation (defined as scores < 12) one year after delivery. The Child Behavior Checklist 1½-5 was used to assess behavioral problems, and its subscales were used to assess internalizing and externalizing problems in children at 4 years of age. Multiple logistic regression analyses were conducted to examine the associations between social isolation and behavioral problems, after adjustment for age, education, income, work status, marital status, extraversion, neuroticism, depressive symptoms, child sex, and number of siblings. Multiple logistic regression analyses were also conducted for internalizing problems and externalizing problems. The prevalence of maternal social isolation was 25.4%. Maternal social isolation was associated with an increased risk of behavioral problems in children: the odds ratio (OR) was 1.37 (95% confidence interval [CI] 1.14-1.64). Maternal social isolation was also associated with increased risks of internalizing problems and externalizing problems in children: the ORs were 1.33 (95% CI, 1.12-1.59) and 1.40 (95% CI, 1.18-1.66), respectively. In conclusion, maternal social isolation one year after delivery was associated with behavioral problems in children at 4 years of age.
母親における出産前後の社会的孤立と児の発達との関連三世代コホート調査

村上慶子, 野田あおい, 石黒真美, 小原拓, 上野史彦, 菊地紗耶, 小林奈津子, 濱田裕貴, 岩間憲之, 目時弘仁, 齋藤昌利, 菅原準一, 富田博秋, 八重樫伸生, 栗山進一

日本衛生学雑誌　78　(Suppl.)　S173-S173　2023/03
Publisher: (一社)日本衛生学会
ISSN： 0021-5082

eISSN： 1882-6482
Maternal postnatal bonding disorder and developmental delays in children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Keiko Murakami, Aoi Noda, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Archives of women's mental health　26　(2)　219-226　2023/02/21

DOI： 10.1007/s00737-023-01298-0 　

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Although there is some evidence regarding an association between maternal bonding disorder and child development, studies have mainly focused on development during the period of infancy. We aimed to examine the associations between maternal postnatal bonding disorder and developmental delays in children beyond 2 years of age. We analyzed data from 8380 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Maternal bonding disorder was defined as Mother-to-Infant Bonding Scale score of ≥5 at 1 month after delivery. The Ages & Stages Questionnaires, Third Edition, which consists of five developmental areas, was used to assess developmental delays in children at 2 and 3.5 years of age. Multiple logistic regression analyses were conducted to examine the associations between postnatal bonding disorder and developmental delays after adjustment for age, education, income, parity, feelings toward pregnancy, postnatal depressive symptoms, child's sex, preterm birth, and birth defects. Bonding disorder was associated with developmental delays in children at 2 and 3.5 years of age: the odds ratios (95% confidence intervals) were 1.55 (1.32-1.83) and 1.60 (1.34-1.90), respectively. Bonding disorder was associated with delay in communication only at 3.5 years of age. Bonding disorder was associated with delay in gross motor, fine motor, and problem solving, but not delay in the personal-social domain, at 2 and 3.5 years of age. In conclusion, maternal bonding disorder 1 month after delivery was associated with an increased risk of developmental delays in children beyond 2 years of age.
Decreased β‐hydroxybutyrate and ketogenic amino acid levels in depressed human adults

Shiho Sato, Zhiqian Yu, Mai Sakai, Ikuko N. Motoike, Daisuke Saigusa, Ryo Hirayama, Yoshie Kikuchi, Takaaki Abe, Kengo Kinoshita, Seizo Koshiba, Hiroaki Tomita

European Journal of Neuroscience　2023/02/07
Publisher: Wiley
DOI： 10.1111/ejn.15931 　

ISSN： 0953-816X

eISSN： 1460-9568
母親の社会的孤立と児の問題行動の関連東北メディカル・メガバンク計画三世代コホート調査

村上慶子, 石黒真美, 小原拓, 上野史彦, 野田あおい, 大沼ともみ, 松崎芙実子, 高橋一平, 菊地紗耶, 小林奈津子, 濱田裕貴, 岩間憲之, 目時弘仁, 菊谷昌浩, 齋藤昌利, 菅原準一, 富田博秋, 八重樫伸生, 栗山進一

Journal of Epidemiology　33　(Suppl.1)　92-92　2023/02
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
Microarray dataset of gene transcription in mouse microglia and peripheral monocytes in contextual fear conditioning

Zhiqian Yu, Mai Sakai, Hotaka Fukushima, Chiaki Ono, Yoshie Kikuchi, Ryuta Koyama, Ko Matsui, Tomoyuki Furuyashiki, Satoshi Kida, Hiroaki Tomita

Data in Brief　46　108862-108862　2023/02
Publisher: Elsevier BV
DOI： 10.1016/j.dib.2022.108862 　

ISSN： 2352-3409
Maternal postnatal bonding disorder and emotional/behavioral problems in preschool children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Keiko Murakami, Mami Ishikuro, Taku Obara, Aoi Noda, Fumihiko Ueno, Tomomi Onuma, Fumiko Matsuzaki, Ippei Takahashi, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Journal of affective disorders　325　582-587　2023/01/12

DOI： 10.1016/j.jad.2023.01.044 　

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BACKGROUND: Although there is some evidence that maternal perinatal mental disorders are associated with emotional/behavioral problems in children, the long-term impacts of postnatal bonding disorder remain unclear. We aimed to examine the associations between maternal postnatal bonding disorder and emotional/behavioral problems in preschool children. METHODS: We analyzed data from 7220 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Maternal bonding disorder was defined as Mother-to-Infant Bonding Scale score ≥5 at 1 month after delivery. The Child Behavior Checklist 1½-5 was used to assess emotional/behavioral problems, and its subscales were used to assess internalizing and externalizing problems in children at 4 years of age. Multiple logistic regression analyses were conducted to examine the associations of postnatal bonding disorder with emotional/behavioral, internalizing, and externalizing problems after adjustment for age, education, income, parity, prenatal psychological distress, postnatal depressive symptoms, child's sex, preterm birth, and birth defects. RESULTS: The prevalence of postnatal bonding disorder was 14.8 %. Postnatal bonding disorder was associated with an increased risk of emotional/behavioral problems in children: the odds ratio (OR) was 2.06 (95 % confidence interval [CI], 1.72-2.46). Postnatal bonding disorder was also associated with increased risks of internalizing problems and externalizing problems in children: the ORs were 1.69 (95 % CI, 1.42-2.02) and 1.90 (95 % CI, 1.59-2.26), respectively. LIMITATIONS: Bonding and problems were self-reported. CONCLUSIONS: Bonding disorder at 1 month after delivery was associated with an increased risk of emotional/behavioral problems in children at 4 years of age.
Risk Factors Associated With Peripartum Suicide Attempts in Japan. International-journal

Tetsuya Akaishi, Kunio Tarasawa, Kiyohide Fushimi, Hirotaka Hamada, Masatoshi Saito, Natsuko Kobayashi, Saya Kikuchi, Hiroaki Tomita, Tadashi Ishii, Kenji Fujimori, Nobuo Yaegashi

JAMA network open　6　(1)　e2250661　2023/01/03

DOI： 10.1001/jamanetworkopen.2022.50661 　

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IMPORTANCE: Peripartum suicide attempt is a major psychiatric complication associated with pregnancy, but the risk factors remain largely uncertain. OBJECTIVE: To identify the demographic characteristics and predisposing risks for peripartum suicide attempts and postpartum depression. DESIGN, SETTING, AND PARTICIPANTS: This cohort study used retrospective data on pregnant women who delivered children between April 1, 2016, and March 31, 2021, at 712 hospitals in Japan. The nationwide Diagnosis Procedure Combination database was used. EXPOSURES: Psychiatric and nonpsychiatric medical history, age, alcohol and tobacco use, and obstetric complications and procedures. MAIN OUTCOMES AND MEASURES: Data on admissions for prepartum suicide attempt and delivery during the same hospital stay and readmissions for depression or suicide attempt within 1 year post partum were collected. Comparisons of prevalence of each study variable were performed, and multivariable logistic regression analyses were used to determine risk factors. RESULTS: From a total of 39 908 649 hospitalization episodes, 804 617 cumulative pregnant women (median [IQR] age at childbirth, 33 [29-36] years) who delivered at the enrolled hospitals were identified, including 1202 who were admitted for suicide attempt and delivery during the same hospital stay and 111 readmitted for suicide attempt within 1 year post partum. Risk factors associated with prepartum suicide attempts included younger age (adjusted odds ratio [aOR], 0.99; 95% CI, 0.98-1.00) and histories of personality disorder (aOR, 10.81; 95% CI, 5.70-20.49), depression (aOR, 3.97; 95% CI, 2.35-6.70), schizophrenia (aOR, 2.89; 95% CI, 1.52-5.50), and adjustment disorder (aOR, 2.66; 95% CI, 1.07-6.58). Risk factors associated with postpartum suicide attempts included younger age (aOR, 0.96; 95% CI, 0.93-1.00), heavy tobacco use (aOR, 23.09; 95% CI, 5.46-97.62), and histories of alcohol use disorder (aOR, 163.54; 95% CI, 28.30-944.95), personality disorder (aOR, 10.28; 95% CI, 3.29-32.10), anxiety disorders (aOR, 8.13; 95% CI, 2.88-22.98), depression (aOR, 7.27; 95% CI, 2.95-17.91), schizophrenia (aOR, 5.77; 95% CI, 2.17-15.38), bipolar disorder (aOR, 3.98; 95% CI, 1.36-11.67), and insomnia (aOR, 3.17; 95% CI, 1.30-7.78). On sensitivity analysis, risk factors associated with postpartum depression after excluding those with prenatal depression included histories of personality disorder, adjustment disorder, bipolar disorder, insomnia, and anxiety disorders. CONCLUSIONS AND RELEVANCE: The findings of this cohort study suggest that histories of smoking and prenatal psychiatric disorders are potential risk factors for peripartum suicide attempts and may require additional treatment and prevention interventions.
Evidence for increased DNA damage repair in the postmortem brain of the high stress-response group of schizophrenia. International-journal

Risa Shishido, Yasuto Kunii, Mizuki Hino, Ryuta Izumi, Atsuko Nagaoka, Hideki Hayashi, Akiyoshi Kakita, Hiroaki Tomita, Hirooki Yabe

Frontiers in psychiatry　14　1183696-1183696　2023

DOI： 10.3389/fpsyt.2023.1183696 　

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BACKGROUND: Schizophrenia (SZ) is a disorder diagnosed by specific symptoms and duration and is highly heterogeneous, clinically and pathologically. Although there are an increasing number of studies on the association between genetic and environmental factors in the development of SZ, the actual distribution of the population with different levels of influence of these factors has not yet been fully elucidated. In this study, we focused on stress as an environmental factor and stratified SZ based on the expression levels of stress-responsive molecules in the postmortem prefrontal cortex. METHODS: We selected the following stress-responsive molecules: interleukin (IL) -1β, IL-6, IL-10, tumor necrosis factor-α, interferon-γ, glucocorticoid receptor, brain-derived neurotrophic factor, synaptophysin, S100 calcium-binding protein B, superoxide dismutase, postsynaptic density protein 95, synuclein, apolipoprotein A1 (ApoA1), ApoA2, and solute carrier family 6 member 4. We performed RNA sequencing in the prefrontal gray matter of 25 SZ cases and 21 healthy controls and conducted a hierarchical cluster analysis of SZ based on the gene expression levels of stress-responsive molecules, which yielded two clusters. After assessing the validity of the clusters, they were designated as the high stress-response SZ group and the low stress-response SZ group, respectively. Ingenuity Pathway Analysis of differentially expressed genes (DEGs) between clusters was performed, and Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining was conducted on four cases each in the high and low stress-response SZ groups to validate DNA damage. RESULTS: We found higher prevalence of family history of SZ in the low stress-response SZ group (0/3 vs. 5/4, p = 0.04). Pathway analysis of DEGs between clusters showed the highest enrichment for DNA double-strand break repair. TUNEL staining showed a trend toward a lower percentage of TUNEL-positive cells in the high stress-response SZ group. CONCLUSION: Our results suggest that there are subgroups of SZ with different degrees of stress impact. Furthermore, the pathophysiology of these subgroups may be associated with DNA damage repair. These results provide new insights into the interactions and heterogeneity between genetic and environmental factors.
Plasma metabolic disturbances during pregnancy and postpartum in women with depression. International-journal Peer-reviewed

Zhiqian Yu, Naomi Matsukawa, Daisuke Saigusa, Ikuko N Motoike, Chiaki Ono, Yasunobu Okamura, Tomomi Onuma, Yuta Takahashi, Mai Sakai, Hisaaki Kudo, Taku Obara, Keiko Murakami, Matusyuki Shirota, Saya Kikuchi, Natsuko Kobayashi, Yoshie Kikuchi, Junichi Sugawara, Naoko Minegishi, Soichi Ogishima, Kengo Kinoshita, Masayuki Yamamoto, Nobuo Yaegashi, Shinichi Kuriyama, Seizo Koshiba, Hiroaki Tomita

iScience　25　(12)　105666-105666　2022/12/22

DOI： 10.1016/j.isci.2022.105666 　

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Examining plasma metabolic profiling during pregnancy and postpartum could help clinicians understand the risk factors for postpartum depression (PPD) development. This analysis targeted paired plasma metabolites in mid-late gestational and 1 month postpartum periods in women with (n = 209) or without (n = 222) PPD. Gas chromatogram-mass spectrometry was used to analyze plasma metabolites at these two time points. Among the 170 objected plasma metabolites, principal component analysis distinguished pregnancy and postpartum metabolites but failed to discriminate women with and without PPD. Compared to women without PPD, those with PPD exhibited 37 metabolites with disparate changes during pregnancy and the 1-month postpartum period and an enriched citrate cycle. Machine learning and multivariate statistical analysis identified two or three compounds that could be potential biomarkers for PPD prediction during pregnancy. Our findings suggest metabolic disturbances in women with depression and may help to elucidate metabolic processes associated with PPD development.
Sex-Specific Differences in the Transcriptome of the Human Dorsolateral Prefrontal Cortex in Schizophrenia. International-journal

Zhiqian Yu, Kazuko Ueno, Ryo Funayama, Mai Sakai, Naoki Nariai, Kaname Kojima, Yoshie Kikuchi, Xue Li, Chiaki Ono, Junpei Kanatani, Jiro Ono, Kazuya Iwamoto, Kenji Hashimoto, Kengo Kinoshita, Keiko Nakayama, Masao Nagasaki, Hiroaki Tomita

Molecular neurobiology　60　(2)　1083-1098　2022/11/22

DOI： 10.1007/s12035-022-03109-6 　

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Schizophrenia presents clinical and biological differences between males and females. This study investigated transcriptional profiles in the dorsolateral prefrontal cortex (DLPFC) using postmortem data from the largest RNA-sequencing (RNA-seq) database on schizophrenic cases and controls. Data for 154 male and 113 female controls and 160 male and 93 female schizophrenic cases were obtained from the CommonMind Consortium. In the RNA-seq database, the principal component analysis showed that sex effects were small in schizophrenia. After we analyzed the impact of sex-specific differences on gene expression, the female group showed more significantly changed genes compared with the male group. Based on the gene ontology analysis, the female sex-specific genes that changed were overrepresented in the mitochondrion, ATP (phosphocreatine and adenosine triphosphate)-, and metal ion-binding relevant biological processes. An ingenuity pathway analysis revealed that the differentially expressed genes related to schizophrenia in the female group were involved in midbrain dopaminergic and γ-aminobutyric acid (GABA)-ergic neurons and microglia. We used methylated DNA-binding domain-sequencing analyses and microarray to investigate the DNA methylation that potentially impacts the sex differences in gene transcription using a maternal immune activation (MIA) murine model. Among the sex-specific positional genes related to schizophrenia in the PFC of female offspring from MIA, the changes in the methylation and transcriptional expression of loci ACSBG1 were validated in the females with schizophrenia in independent postmortem samples by real-time PCR and pyrosequencing. Our results reveal potential genetic risks in the DLPFC for the sex-dependent prevalence and symptomology of schizophrenia.
Association of maternal psychological distress and the use of childcare facilities with children's behavioral problems: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal Peer-reviewed

Ippei Takahashi, Keiko Murakami, Mika Kobayashi, Saya Kikuchi, Ayaka Igarashi, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shigeo Kure, Shinichi Kuriyama

BMC psychiatry　22　(1)　693-693　2022/11/11

DOI： 10.1186/s12888-022-04330-2 　

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BACKGROUND: Childcare facilities are a factor that lowers the established association of mother's postnatal psychiatric symptoms with children's behavioral problems. However, no studies have considered the prenatal psychiatric symptoms yet. This study examined whether the use of childcare facilities moderates the association of maternal psychological distress in early pregnancy and at two years postpartum with behavioral problems in children aged four years. METHODS: The present study was based on the data from 23,130 mother-child pairs participating in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. K6 was used to classify maternal psychological distress in early pregnancy and at two years postpartum into four categories: none in both prenatal and postnatal periods (none), only the prenatal period (prenatal only); only the postnatal period (postnatal only); both prenatal and postnatal periods (both). The children's behavioral problems were assessed using the Child Behavior Checklist for Ages 1½-5 (CBCL) aged four years. The clinical range of the externalizing, internalizing, and total problem scales of the CBCL was defined as having behavioral problems. To examine whether availing childcare facilities moderates the association between maternal psychological distress and children's behavioral problems, we conducted a stratified analysis based on the use of childcare facilities or not, at two years of age. The interaction term between maternal psychological distress and use of childcare facilities was included as a covariate in the multivariate logistic regression analysis to confirm the p-value for the interaction. RESULTS: The prevalence of the clinical ranges of externalizing problems, internalizing problems, and clinical range of total problems were 13.7%, 15.4%, and 5.8%, respectively. The association of maternal psychological distress with a high risk of children's behavioral problems was significant; however, the association between prenatal only psychological distress and externalizing problems in the group that did not use childcare facilities was not significant. Interactions between the use of childcare facilities and maternal psychological distress on behavioral problems in children were not significant. CONCLUSIONS: Use of childcare facilities did not moderate the association of maternal psychological distress in early pregnancy and at two years postpartum with behavioral problems in children aged four years.
Social isolation and insomnia among pregnant women in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Sleep health　8　(6)　714-720　2022/10/10

DOI： 10.1016/j.sleh.2022.08.007 　

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OBJECTIVES: To estimate the prevalence of insomnia and examine the association between social isolation and insomnia among pregnant women. METHODS: This cross-sectional study was part of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study from 2013 to 2017. Pregnant women were recruited at obstetric clinics and hospitals in Miyagi Prefecture, Japan. We analyzed 17,586 women who completed the questionnaires and were allowed to transcribe medical records. Insomnia was defined as the Athens Insomnia Scale score of ≥6. The Lubben Social Network Scale-abbreviated version was used to assess social isolation (defined as scores <12), and its subscales were used to assess marginal family ties and marginal friendship ties. Multiple logistic regression analyses were conducted to examine the association between social isolation and insomnia during pregnancy, adjusting for age, parity, prepregnancy body mass index, feelings toward pregnancy, education, income, work status, morning sickness, and psychological distress. Multiple logistic regression analyses were also conducted for marginal family ties and marginal friendship ties. RESULTS: The prevalence of insomnia in the second trimester was 37.3%. Women who were socially isolated were more likely to have insomnia than women who were socially integrated: the multivariate-adjusted odds ratio (OR) was 1.26 (95% confidence interval [CI], 1.16-1.36). Marginal family ties and marginal friendship ties were also associated with increased risks of insomnia: the multivariate-adjusted ORs were 1.40 (95% CI, 1.25-1.56) and 1.15 (95% CI, 1.07-1.24), respectively. CONCLUSIONS: Social isolation from family and friends was associated with increased risks of insomnia among pregnant women.
精神科リエゾンでの簡易脳波計東北大学病院オープンベッドラボ(OBL)での試用

佐久間篤, 内海裕介, 鴇田百合子, 五十嵐江美, 鈴木美野里, 浅黄優, 辻本悠郁子, 落合康, 三木俊, 中川敦寛, 中里信和, 富田博秋

総合病院精神医学　34　(Suppl.)　S-202　2022/10
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
入院中のがん患者における身体活動量とせん妄文献的レビューに基づく考察

五十嵐江美, 内海裕介, 鴇田百合子, 佐久間篤, 富田博秋

総合病院精神医学　34　(Suppl.)　S-178　2022/10
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
入院化学療法中のがん患者の抑うつ,不安,せん妄症状とウェアラブルデバイスによる身体活動量との関連

内海裕介, 五十嵐江美, 佐久間篤, 鴇田百合子, 富田博秋

総合病院精神医学　34　(Suppl.)　S-171　2022/10
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
精神科リエゾンでの簡易脳波計東北大学病院オープンベッドラボ(OBL)での試用

佐久間篤, 内海裕介, 鴇田百合子, 五十嵐江美, 鈴木美野里, 浅黄優, 辻本悠郁子, 落合康, 三木俊, 中川敦寛, 中里信和, 富田博秋

総合病院精神医学　34　(Suppl.)　S-202　2022/10
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
Traumatic experiences of the Great East Japan Earthquake and postpartum depressive symptoms: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Journal of affective disorders　320　461-467　2022/09/30

DOI： 10.1016/j.jad.2022.09.139 　

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BACKGROUND: Natural disasters can have serious mental health consequences. We aimed to examine the long-term effects of the 2011 Great East Japan Earthquake (GEJE) on postpartum depressive symptoms (PDS). METHODS: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study recruited pregnant women in Miyagi Prefecture from 2013 to 2016. Data from 11,403 participants were used in this study. Women were asked about their traumatic experiences of the GEJE with questions addressing threat, witness, and loss. PDS were defined as Edinburgh Postnatal Depression Scale score ≥9 at 1 month after delivery. Multiple logistic regression analyses were conducted to examine the associations of different traumatic experiences of the GEJE and number of traumatic experiences with PDS, after adjustment for age, parity, feelings toward pregnancy, education, income, social isolation, house damage caused by the GEJE, and survey year. RESULTS: About two-fifths of women had at least one traumatic experience of the GEJE. The prevalence of PDS at 1 month after delivery was 13.3 %. Life-threatening experience and witnessing another person's actual or threatened death were associated with PDS: the odds ratios (ORs) were 1.40 (95 % confidence interval [CI], 1.24-1.59) and 1.28 (95 % CI, 1.08-1.53), respectively. Loss of close person was not associated with PDS: the OR was 1.13 (95 % CI, 0.99-1.30). Larger number of traumatic experiences of the GEJE was associated with increased risk of PDS (p for trend <0.001). LIMITATIONS: PDS was self-reported. CONCLUSIONS: Traumatic experiences of the GEJE prior to pregnancy were associated with increased risks of PDS.
Social isolation and postnatal bonding disorder in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Archives of Women's Mental Health　2022/09/17
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s00737-022-01266-0 　

ISSN： 1434-1816

eISSN： 1435-1102
うつ病相での自殺企図後に躁転し、再企図防止策を講じた双極性障害の1例

曽良かおり, 五十嵐江美, 飯塚邦夫, 佐藤祐太朗, 桂雅宏, 阿部光一, 富田博秋

精神神経学雑誌　124　(9)　653-653　2022/09
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
双極性障害患者におけるスーパー救急病棟入院後の簡易型集団心理教育参加後のself-stigmaの変化

小松浩, 大野高志, 高梨央康, 酒井道代, 芳野昭文, 岡村知保, 石黒奈々子, 伊木威和, 菅原聡美, 小野口豪, 富田博秋, 角藤芳久

日本精神科救急学会学術総会プログラム・抄録集　30回　140-140　2022/09
Publisher: (一社)日本精神科救急学会
Successful rechallenge with clozapine after discontinuation due to drug‐induced pneumonia: A case report

Yuki Kikuchi, Hiroshi Komatsu, Atsushi Sakuma, Hiroaki Tanifuji, Hiroaki Tomita

Psychiatry and Clinical Neurosciences Reports　1　(3)　2022/09
Publisher: Wiley
DOI： 10.1002/pcn5.38 　

ISSN： 2769-2558

eISSN： 2769-2558
Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia. International-journal

Zhiqian Yu, Mai Sakai, Hotaka Fukushima, Chiaki Ono, Yoshie Kikuchi, Ryuta Koyama, Ko Matsui, Tomoyuki Furuyashiki, Satoshi Kida, Hiroaki Tomita

Brain research bulletin　189　57-68　2022/08/17

DOI： 10.1016/j.brainresbull.2022.08.017 　

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Microglia have been suggested to be involved in the underlying mechanism of conditional fear memory formation by regulating inflammatory cytokines. However, the mechanism linking microglia and neuronal activity related to fear conditioning remains unclear. This study characterized the transcription profile of microglia in a fear memory conditional mouse model. Compared with those in control mice microglia, the most significantly induced genes were synapse-related, whereas immune-related genes were reduced due to fear memory consolidation. Whilst the increased expression of synapse-related genes was reversed after fear memory extinction, that of immunological genes was not, strongly suggesting a connection between microglia, neurons, and a dysregulated immune response following contextual fear conditioning. Furthermore, in the hippocampal microglia, we found that the expression of neurotransmitter release regulators, γ-aminobutyric acid (GABA) receptor GABRB3 and synapsin 1/2, increased under fear memory consolidation and restored (decreased) after extinction. In addition, compared with the transcription profile in peripheral monocytes, few overlapping genes were not enriched in biological processes. Taken together, the identified conditional fear stress-induced changes in mouse microglial transcription profiles suggest that microglia-neuron communication mediates contextual fear conditioning.
医療における危機と再生〜東日本大震災から新型コロナウイルスまで〜大規模災害とコミュニティのレジリエンス精神医学の視点から

富田博秋, 國井泰人, 濱家由美子, 臼倉瞳, 瀬戸萌, 内海裕介

てんかん研究　40　(2)　265-265　2022/08
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
Association between maternal infertility treatment and child neurodevelopment: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan. International-journal

Aoi Noda, Mami Ishikuro, Taku Obara, Keiko Murakami, Fumihiko Ueno, Fumiko Matsuzaki, Tomomi Onuma, Zen Watanabe, Naomi Shiga, Noriyuki Iwama, Hamada Hirotaka, Tatsui Otsuka, Masahito Tachibana, Hiroaki Tomita, Masatoshi Saito, Junichi Sugawara, Shigeo Kure, Nobuo Yaegashi, Shinichi Kuriyama

BMJ open　12　(6)　e060944　2022/06/07

DOI： 10.1136/bmjopen-2022-060944 　

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OBJECTIVES: This study aimed to examine the association between infertility treatment and neurodevelopment in children at 2 and 3.5 years of age. DESIGN: Prospective cohort study. SETTING AND PARTICIPANTS: The study population consisted of mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan. Pregnant women were recruited in obstetric clinics or hospitals and their children were followed up by the questionnaire. OUTCOME MEASURES: The children's neurodevelopmental outcomes were assessed at 2 and 3.5 years of age using the Ages and Stages Questionnaire, third edition (ASQ-3), which consists of questions on five developmental domains. We performed a multivariate logistic regression analysis of the association between infertility treatment (including ovulation induction (OI), artificial insemination with husband's sperm (AIH) and assisted reproductive technology (ART)) and the clinical range of ASQ-3. RESULTS: Of 9655 mother-child pairs, 273 (2.8%) and 487 (5.0%) were conceived through OI/AIH and ART, respectively. The odds of having developmental delays at 2 years of age were higher in children conceived through OI/AIH (OR, 1.36; 95% CI 1.00 to 1.85) and ART (OR, 1.36; 95% CI 1.07 to 1.72) than in those conceived naturally. Additionally, OI/AIH and ART were significantly associated with communication (OR, 1.93; 95% CI 1.25 to 2.98) and gross motor (OR, 1.50; 95% CI 1.08 to 2.09) delays, respectively. There were no statistically significant differences in the odds of having developmental delays at 3.5 years of age in children conceived through OI/AIH (OR, 1.13; 95% CI 0.79 to 1.61) and ART (OR, 1.03; 95% CI 0.78 to 1.37). CONCLUSION: In this study, we found a significant association between infertility treatment and children's neurodevelopment at 2 years of age, whereas no statistically significant differences were found at 3.5 years of age.
Review of Mental Health Consequences of the Great East Japan Earthquake through Long-Term Epidemiological Studies: The Shichigahama Health Promotion Project.

Yasuto Kunii, Hitomi Usukura, Yusuke Utsumi, Moe Seto, Yumiko Hamaie, Yumi Sugawara, Naoki Nakaya, Shinichi Kuriyama, Atsushi Hozawa, Ichiro Tsuji, Hiroaki Tomita

The Tohoku journal of experimental medicine　257　(2)　85-95　2022/06/04

DOI： 10.1620/tjem.2022.J039 　

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After the Great East Japan Earthquake, Tohoku University began to provide mental health services during the acute phase of the disaster in cooperation with Shichigahama Town, one of the municipalities located in the coastal area of the Miyagi Prefecture that was severely damaged by the earthquake and tsunami; it continued to be providing long-term mental health activities, incorporating annual surveys for affected residents in the town for 10 years. Ten years of combination of surveys and outreach activities first depicted detailed longitudinal alterations in the mental health conditions of communities affected by a catastrophe. While posttraumatic stress reaction had recovered year by year after the year following the Great East Japan Earthquake, recovery from psychological distress retreated between 2014 and 2017, probably due to the relocation from temporal to eternal housing conditions. The annual cycles of assessment and provision of mental health support and promotion activities continued for 10 years can be an initial model for evidence-based, long-term post-disaster mental health and psychosocial support for the affected communities. Data regarding subsequent disasters should be collected in comparable ways, in order to improve the accuracy and usefulness of the accumulated data for planning and providing evidence-based post-disaster mental health and psychosocial support.
RELN rs7341475 Associates with Brain Structure in Japanese Healthy Females. International-journal

Ryo Yamaguchi, Izumi Matsudaira, Hikaru Takeuchi, Tadashi Imanishi, Ryosuke Kimura, Hiroaki Tomita, Ryuta Kawashima, Yasuyuki Taki

Neuroscience　494　38-50　2022/05/13

DOI： 10.1016/j.neuroscience.2022.05.007 　

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Although temperament has been regarded as an innate aspect of human personality, its association with proteins involved in embryonic development is unclear. Reelin, encoded by RELN, plays an important role in brain development. Herein, we investigated the association between the RELN rs7341475 (G/A) single nucleotide polymorphism, detected as a female-specific risk factor for schizophrenia, brain structure, and temperament to elucidate the role of RELN in the development of human personality. In this study, 1580 healthy young Japanese adults were genotyped for RELN rs7341475 and completed the Temperament and Character Inventory. Whole-brain analysis of covariance was conducted to investigate differences between genotypes in regional gray matter volume (rGMV) and cortical morphology. Additionally, multiple regression analysis was performed to examine the association of four temperaments with rGMV. Those statistical analyses were performed separately for males and females. Individuals with G/G homozygosity showed significantly greater rGMV in several areas of the brain, particularly the bilateral cingulate and temporal gyrus, as well as a larger value of fractal dimension in the left lateral occipital cortex. Furthermore, of the four temperaments, the novelty seeking was significantly and positively associated with rGMV in the right superior temporal gyrus, partially overlapping with areas where differences between the rs7341475 genotypes were detected. The above findings were detected only in females, but not in males. This is the first study to demonstrate the contribution of RELN rs7341475 to differences in brain structure in Japanese females, which may indicate vulnerability to schizophrenia and variations in human personality.
Retinal layers and associated clinical factors in schizophrenia spectrum disorders: a systematic review and meta-analysis

Hiroshi Komatsu, Goh Onoguchi, Stefan Jerotic, Nobuhisa Kanahara, Yoshihisa Kakuto, Takashi Ono, Shunichi Funakoshi, Takeshi Yabana, Toru Nakazawa, Hiroaki Tomita

Molecular Psychiatry　2022/05/02
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s41380-022-01591-x 　

ISSN： 1359-4184

eISSN： 1476-5578
Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial International-journal Peer-reviewed

Hidenori Yamasue, Masaki Kojima, Hitoshi Kuwabara, Miho Kuroda, Kaori Matsumoto, Chieko Kanai, Naoko Inada, Keiho Owada, Keiko Ochi, Nobutaka Ono, Seico Benner, Tomoyasu Wakuda, Yosuke Kameno, Jun Inoue, Taeko Harada, Kenji Tsuchiya, Kazuo Umemura, Aya Yamauchi, Nanayo Ogawa, Itaru Kushima, Norio Ozaki, Satoshi Suyama, Takuya Saito, Yukari Uemura, Junko Hamada, Yukiko Kano, Nami Honda, Saya Kikuchi, Moe Seto, Hiroaki Tomita, Noriko Miyoshi, Megumi Matsumoto, Yuko Kawaguchi, Koji Kanai, Manabu Ikeda, Itta Nakamura, Shuichi Isomura, Yoji Hirano, Toshiaki Onitsuka, Hirotaka Kosaka, Takashi Okada

Brain　145　(2)　490-499　2022/04/18
Publisher: Oxford University Press (OUP)
DOI： 10.1093/brain/awab291 　

ISSN： 0006-8950

eISSN： 1460-2156

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Abstract Although intranasal oxytocin is expected to be a novel therapy for the core symptoms of autism spectrum disorder, which has currently no approved medication, the efficacy of repeated administrations was inconsistent, suggesting that the optimal dose for a single administration of oxytocin is not optimal for repeated administration. The current double-blind, placebo-controlled, multicentre, crossover trial (ClinicalTrials.gov Identifier: NCT03466671) was aimed to test the effect of TTA-121, a new formulation of intranasal oxytocin spray with an enhanced bioavailability (3.6 times higher than Syntocinon® spray, as assessed by area under the concentration–time curve in rabbit brains), which enabled us to test a wide range of multiple doses, on autism spectrum disorder core symptoms and to determine the dose–response relationship. Four-week administrations of TTA-121, at low dose once per day (3 U/day), low dose twice per day (6 U/day), high dose once per day (10 U/day), or high dose twice per day (20 U/day), and 4-week placebo were administered in a crossover manner. The primary outcome was the mean difference in the reciprocity score (range: 0–14, higher values represent worse outcomes) on the Autism Diagnostic Observation Schedule between the baseline and end point of each administration period. This trial with two administration periods and eight groups was conducted at seven university hospitals in Japan, enrolling adult males with high-functioning autism spectrum disorder. Enrolment began from June 2018 and ended December 2019. Follow-up ended March 2020. Of 109 males with high-functioning autism spectrum disorder who were randomized, 103 completed the trial. The smallest P-value, judged as the dose–response relationship, was the contrast with the peak at TTA-121 6 U/day, with inverted U-shape for both the full analysis set (P = 0.182) and per protocol set (P = 0.073). The Autism Diagnostic Observation Schedule reciprocity score, the primary outcome, was reduced in the TTA-121 6 U/day administration period compared with the placebo (full analysis set: P = 0.118, mean difference = −0.5; 95% CI: −1.1 to 0.1; per protocol set: P = 0.012, mean difference = −0.8; 95% CI: −1.3 to −0.2). The per protocol set was the analysis target population, consisting of all full analysis set participants except those who deviated from the protocol. Most dropouts from the full analysis set to the per protocol set occurred because of poor adherence to the test drug (9 of 12 in the first period and 8 of 15 in the second period). None of the secondary clinical and behavioural outcomes were significantly improved with the TTA-121 compared with the placebo in the full analysis set. A novel intranasal spray of oxytocin with enhanced bioavailability enabled us to test a wide range of multiple doses, revealing an inverted U-shape dose–response curve, with the peak at a dose that was lower than expected from previous studies. The efficacy of TTA-121 shown in the current exploratory study should be verified in a future large-scale, parallel-group trial.
Maternal personality and postpartum mental disorders in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Scientific reports　12　(1)　6400-6400　2022/04/16

DOI： 10.1038/s41598-022-09944-w 　

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Personality has been shown to predict postpartum depressive symptoms (PDS) assessed by the Edinburgh Postnatal Depression Scale (EPDS). However, existing studies have not considered the underlying symptom dimensions in the EPDS. We analyzed data from 15,012 women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Personality was assessed in middle pregnancy using the short-form Eysenck Personality Questionnaire-Revised. PDS were defined as EPDS score ≥ 9 at 1 month after delivery. The EPDS items were further divided into three dimensions: depressed mood, anxiety, and anhedonia. Multiple analyses were conducted to examine the associations of each personality scale with PDS and three dimensions in the EPDS, adjusting for age, parity, mode of delivery, education, income, and social isolation. The prevalence of PDS assessed by the EPDS at 1 month after delivery was 13.1%. Higher neuroticism scores were associated with PDS (odds ratio [OR], 2.63; 95% confidence interval [CI], 2.48 to 2.79) and all three dimensions (all p < 0.001). Lower extraversion scores were associated with PDS (OR, 0.74; 95% CI, 0.70 to 0.78) and all three dimensions (all p < 0.001). Lower psychoticism scores were associated with PDS (OR, 0.89; 95% CI, 0.85 to 0.94) and anxiety (p < 0.001), but not with depressed mood (p = 0.20) or anhedonia (p = 0.92). In conclusion, higher neuroticism and lower extraversion were associated with PDS and the three underlying dimensions in the EPDS, while lower psychoticism was associated with anxiety, but not with depressed mood or anhedonia.
A Pilot Study for Return of Individual Pharmacogenomic Results to Population-Based Cohort Study Participants. Peer-reviewed

Kinuko Ohneda, Masahiro Hiratsuka, Hiroshi Kawame, Fuji Nagami, Yoichi Suzuki, Kichiya Suzuki, Akira Uruno, Mika Sakurai-Yageta, Yohei Hamanaka, Makiko Taira, Soichi Ogishima, Shinichi Kuriyama, Atsushi Hozawa, Hiroaki Tomita, Naoko Minegishi, Junichi Sugawara, Inaho Danjoh, Tomohiro Nakamura, Tomoko Kobayashi, Yumi Yamaguchi-Kabata, Shu Tadaka, Taku Obara, Eiji Hishimuma, Nariyasu Mano, Masaki Matsuura, Yuji Sato, Masateru Nakasone, Yohei Honkura, Jun Suzuki, Yukio Katori, Yoichi Kakuta, Atsushi Masamune, Yoko Aoki, Masaharu Nakayama, Shigeo Kure, Kengo Kinoshita, Nobuo Fuse, Masayuki Yamamoto

JMA journal　5　(2)　177-189　2022/04/15

DOI： 10.31662/jmaj.2021-0156 　

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Introduction: Pharmacogenomic (PGx) testing results provide valuable information on drug selection and appropriate dosing, maximization of efficacy, and minimization of adverse effects. Although the number of large-scale, next-generation-sequencing-based PGx studies has recently increased, little is known about the risks and benefits of returning PGx results to ostensibly healthy individuals in research settings. Methods: Single-nucleotide variants of three actionable PGx genes, namely, MT-RNR1, CYP2C19, and NUDT15, were returned to 161 participants in a population-based Tohoku Medical Megabank project. Informed consent was obtained from the participants after a seminar on the outline of this study. The results were sent by mail alongside sealed information letter intended for clinicians. As an exception, genetic counseling was performed for the MT-RNR1 m.1555A > G variant carriers by a medical geneticist, and consultation with an otolaryngologist was encouraged. Questionnaire surveys (QSs) were conducted five times to evaluate the participants' understanding of the topic, psychological impact, and attitude toward the study. Results: Whereas the majority of participants were unfamiliar with the term PGx, and none had undergone PGx testing before the study, more than 80% of the participants felt that they could acquire basic PGx knowledge sufficient to understand their genomic results and were satisfied with their potential benefit and use in future prescriptions. On the other hand, some felt that the PGx concepts or terminology was difficult to fully understand and suggested that in-person return of the results was desirable. Conclusions: These results collectively suggest possible benefits of returning preemptive PGx information to ostensibly healthy cohort participants in a research setting.
A psychiatric disorder risk polymorphism of <scp>ITIH3</scp> is associated with multiple neuroimaging phenotypes in young healthy adults

Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono(Tanaka), Zhiqian Yu, Izumi Matsudaira, Rui Nouchi, Tadashi Imanishi, Ryuta Kawashima

Psychiatry and Clinical Neurosciences　2022/04/05
Publisher: Wiley
DOI： 10.1111/pcn.13347 　

ISSN： 1323-1316

eISSN： 1440-1819
統合失調症スペクトラム障害における網膜層異常と臨床要因との関連性系統的レビューとメタ解析

小松浩, 小野口豪, Jerotic Stefan, 金原信久, 角藤芳久, 大野高志, 舩越俊一, 矢花武史, 中澤徹, 富田博秋

精神神経学雑誌　124　(4付録)　S-546　2022/04
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
ウエラブルデバイスおよび睡眠ログにより測定した産後早期の睡眠特徴とメンタルヘルスとの関連

菊地紗耶, 小林奈津子, 小野千晶, 割田紀子, 木村涼子, 富田博秋

精神神経学雑誌　124　(4付録)　S-378　2022/04
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
入院化学療法中のがん患者へのウェアラブルデバイス活用の試み

内海裕介, 五十嵐江美, 佐久間篤, 富田博秋

精神神経学雑誌　124　(4付録)　S-391　2022/04
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
【妊娠・出産をめぐる最近の話題】妊娠中・産後の精神状態を紐解く

菊地紗耶, 小林奈津子, 富田博秋

保健の科学　64　(4)　242-246　2022/04
Publisher: (株)杏林書院
ISSN： 0018-3342
ウエラブルデバイスおよび睡眠ログにより測定した産後早期の睡眠特徴とメンタルヘルスとの関連

菊地紗耶, 小林奈津子, 小野千晶, 割田紀子, 木村涼子, 富田博秋

精神神経学雑誌　124　(4付録)　S-378　2022/04
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
双極性障害の集団心理教育参加後のself-stigmaの変化と心理教育の満足度、心理状態の変化との関連

小松浩, 大野高志, 高梨央康, 酒井道代, 芳野昭文, 岩崎辰也, 笠原猛, 岡村知保, 石黒奈々子, 伊木威和, 菅原聡美, 小野口豪, 富田博秋, 角藤芳久

精神神経学雑誌　124　(4付録)　S-367　2022/04
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
治療抵抗性統合失調症の分類と治療治療抵抗性統合失調症のサブタイプに基づく新規バイオマーカー同定と病態解明に向けた東北大学の取り組み

小松浩, 小野口豪, 富田博秋

精神神経学雑誌　124　(4付録)　S-478　2022/04
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
統合失調症スペクトラム障害における網膜層異常と臨床要因との関連性系統的レビューとメタ解析

小松浩, 小野口豪, Jerotic Stefan, 金原信久, 角藤芳久, 大野高志, 舩越俊一, 矢花武史, 中澤徹, 富田博秋

精神神経学雑誌　124　(4付録)　S-546　2022/04
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
入院化学療法中のがん患者へのウェアラブルデバイス活用の試み

内海裕介, 五十嵐江美, 佐久間篤, 富田博秋

精神神経学雑誌　124　(4付録)　S-391　2022/04
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan International-journal Peer-reviewed

Nobuo Fuse, Miyuki Sakurai, Ikuko N. Motoike, Kaname Kojima, Takako Takai-Igarashi, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Akiko Miyazawa, Kei Homma, Keisuke Ido, Makiko Taira, Tomoko Kobayashi, Ritsuko Shimizu, Akira Uruno, Eiichi N. Kodama, Kichiya Suzuki, Yohei Hamanaka, Hiroaki Tomita, Junichi Sugawara, Yoichi Suzuki, Fuji Nagami, Soichi Ogishima, Fumiki Katsuoka, Naoko Minegishi, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Yaegashi, Shigeo Kure, Kengo Kinoshita, Masayuki Yamamoto

Ophthalmology Science　2　(1)　100113-100113　2022/03
Publisher: Elsevier BV
DOI： 10.1016/j.xops.2022.100113 　

ISSN： 2666-9145

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PURPOSE: To elucidate the differences in ocular biometric parameters by generation and gender and to identify axial length (AL)-associated genetic variants in Japanese individuals, we analyzed Tohoku Medical Megabank Organization (ToMMo) Eye Study data. DESIGN: We designed the ToMMo Eye Study, examined AL variations, and conducted genome-wide association studies (GWASs). PARTICIPANTS: In total, 33 483 participants aged > 18 years who were recruited into the community-based cohort (CommCohort) and the birth and three-generation cohort (BirThree Cohort) of the ToMMo Eye Study were examined. METHODS: Each participant was screened with an interview, ophthalmic examinations, and a microarray analysis. The GWASs were performed in 22 379 participants in the CommCohort (discovery stage) and 11 104 participants in the BirThree Cohort (replication stage). We evaluated the associations of single nucleotide polymorphisms (SNPs) with AL using a genome-wide significance threshold (5 × 10-8) in each stage of the study and in the subsequent meta-analysis. MAIN OUTCOME MEASURES: We identified the association of SNPs with AL and distributions of AL in right and left eyes and individuals of different sexes and ages. RESULTS: In the discovery stage, the mean AL of the right eye (23.99 mm) was significantly greater than that of the left eye (23.95 mm). This difference was reproducible across sexes and ages. The GWASs revealed 703 and 215 AL-associated SNPs with genome-wide significance in the discovery and validation stages, respectively, and many of the SNPs in the discovery stage were replicated in the validation stage. Validated SNPs and their associated loci were meta-analyzed for statistical significance (P < 5 × 10-8). This study identified 1478 SNPs spread over 31 loci. Of the 31 loci, 5 are known AL loci, 15 are known refractive-error loci, 4 are known corneal-curvature loci, and 7 loci are newly identified loci that are not known to be associated with AL. Of note, some of them shared functional relationships with previously identified loci. CONCLUSIONS: Our large-scale GWASs exploiting ToMMo Eye Study data identified 31 loci linked to variations in AL, 7 of which are newly reported in this article. The results revealed genetic heterogeneity and similarity in SNPs related to ethnic variations in AL.
Lessons learned from psychosocial support and mental health surveys during the 10 years since the Great East Japan Earthquake: Establishing evidence‐based disaster psychiatry

Yasuto Kunii, Hitomi Usukura, Kotaro Otsuka, Masaharu Maeda, Hirooki Yabe, Sho Takahashi, Hirokazu Tachikawa, Hiroaki Tomita

Psychiatry and Clinical Neurosciences　2022/03
Publisher: Wiley
DOI： 10.1111/pcn.13339 　

ISSN： 1323-1316

eISSN： 1440-1819
Deficient Autophagy in Microglia Aggravates Repeated Social Defeat Stress-Induced Social Avoidance

Mai Sakai, Zhiqian Yu, Ryo Hirayama, Masa Nakasato, Yoshie Kikuchi, Chiaki Ono, Hiroshi Komatsu, Miharu Nakanishi, Hatsumi Yoshii, David Stellwagen, Tomoyuki Furuyashiki, Masaaki Komatsu, Hiroaki Tomita

Neural Plasticity　2022　1-13　2022/02/16
Publisher: Hindawi Limited
DOI： 10.1155/2022/7503553 　

ISSN： 2090-5904

eISSN： 1687-5443

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Major depressive disorder (MDD) is associated with repeated exposure to environmental stress. Autophagy is activated under various stress conditions that are associated with several diseases in the brain. This study was aimed at elucidating the autophagy signaling changes in the prefrontal cortex (PFC) under repeated social defeat (RSD) to investigate the involvement of microglial autophagy in RSD-induced behavioral changes. We found that RSD stress, an animal model of MDD, significantly induced initial autophagic signals followed by increased transcription of autophagy-related genes (Atg6, Atg7, and Atg12) in the PFC. Similarly, significantly increased transcripts of ATGs (Atg6, Atg7, Atg12, and Atg5) were confirmed in the postmortem PFC of patients with MDD. The protein levels of the prefrontal cortical LC3B were significantly increased, whereas p62 was significantly decreased in the resilient but not in susceptible mice and patients with MDD. This indicates that enhanced autophagic flux may alleviate stress-induced depression. Furthermore, we identified that FKBP5, an early-stage autophagy regulator, was significantly increased in the PFC of resilient mice at the transcript and protein levels. In addition, the resilient mice exhibited enhanced autophagic flux in the prefrontal cortical microglia, and the autophagic deficiency in microglia aggravated RSD-induced social avoidance, indicating that microglial autophagy involves stress-induced behavioral changes.
Families' Health after the Great East Japan Earthquake: Findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

Mami Ishikuro, Aoii Noda, Keiko Murakami, Tomomi Onuma, Fumiko Matsuzaki, Fumihiko Ueno, Masahiro Kikuya, Hirohito Metoki, Hiroaki Tomita, Taku Obara, Nobuo Yaegashi, Shinichi Kuriyama

The Tohoku journal of experimental medicine　256　(2)　93-101　2022/02

DOI： 10.1620/tjem.256.93 　

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Infectious diseases, chronic diseases, and mental disorders in both adults and children are reported after disasters occur. The correlation between chronic diseases and mental disorders has also been reported. Moreover, disasters may affect perinatal outcomes. Thus, both adult and child health should be carefully monitored in disaster aftermath. A prospective cohort study of pregnant women and their families, the Tohoku Medical Megabank Project (TMM) Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study), has been conducted since 2013. A total of 73,529 family members participated in the TMM BirThree Cohort Study. Among siblings, the proportion of "small for gestational age" was the same in the pre- and post-disaster periods. Among parents and grandparents who answered the baseline questionnaire, 5.6% in the inland area and 19.8% in the coastal area had their houses totally/mostly destroyed by the Great East Japan Earthquake. Although a depression trend due to house damage was not observed in mothers, the proportion of psychological distress was high according to house damage (P for trend = 0.04). Among parents, there was an increase in overweight persons (P for trend = 0.004 in mothers and < 0.0001 in fathers) and in the number of smokers based on the severity of house damage (P for trend = 0.002 in mothers and < 0.0001 in fathers), whereas no such trend was observed in grandparents. Continuous monitoring and support for those who need are essential. Moreover, utilizing existing cohort studies to investigate health status when we face a new disaster is desirable.
Heart Rate Information-Based Machine Learning Prediction of Emotions Among Pregnant Women

Xue Li, Chiaki Ono, Noriko Warita, Tomoka Shoji, Takashi Nakagawa, Hitomi Usukura, Zhiqian Yu, Yuta Takahashi, Kei Ichiji, Norihiro Sugita, Natsuko Kobayashi, Saya Kikuchi, Yasuto Kunii, Keiko Murakami, Mami Ishikuro, Taku Obara, Tomohiro Nakamura, Fuji Nagami, Takako Takai, Soichi Ogishima, Junichi Sugawara, Tetsuro Hoshiai, Masatoshi Saito, Gen Tamiya, Nobuo Fuse, Shinichi Kuriyama, Masayuki Yamamoto, Nobuo Yaegashi, Noriyasu Homma, Hiroaki Tomita

Frontiers in Psychiatry　12　2022/01/27
Publisher: Frontiers Media SA
DOI： 10.3389/fpsyt.2021.799029 　

eISSN： 1664-0640

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In this study, the extent to which different emotions of pregnant women can be predicted based on heart rate-relevant information as indicators of autonomic nervous system functioning was explored using various machine learning algorithms. Nine heart rate-relevant autonomic system indicators, including the coefficient of variation R-R interval (CVRR), standard deviation of all NN intervals (SDNN), and square root of the mean squared differences of successive NN intervals (RMSSD), were measured using a heart rate monitor (MyBeat) and four different emotions including “happy,” as a positive emotion and “anxiety,” “sad,” “frustrated,” as negative emotions were self-recorded on a smartphone application, during 1 week starting from 23rd to 32nd weeks of pregnancy from 85 pregnant women. The k-nearest neighbor (k-NN), support vector machine (SVM), logistic regression (LR), random forest (RF), naïve bayes (NB), decision tree (DT), gradient boosting trees (GBT), stochastic gradient descent (SGD), extreme gradient boosting (XGBoost), and artificial neural network (ANN) machine learning methods were applied to predict the four different emotions based on the heart rate-relevant information. To predict four different emotions, RF also showed a modest area under the receiver operating characteristic curve (AUC-ROC) of 0.70. CVRR, RMSSD, SDNN, high frequency (HF), and low frequency (LF) mostly contributed to the predictions. GBT displayed the second highest AUC (0.69). Comprehensive analyses revealed the benefits of the prediction accuracy of the RF and GBT methods and were beneficial to establish models to predict emotions based on autonomic nervous system indicators. The results implicated SDNN, RMSSD, CVRR, LF, and HF as important parameters for the predictions.
外傷性脳損傷後のフォローアップにおける精神症状のスクリーニングの検討

小鯖貴子, 佐久間篤, 中川敦寛, 八木橋真央, 古谷桂子, 井上昌子, 松井憲子, 富田博秋, 冨永悌二

日本脳神経外傷学会プログラム・抄録集　45回　143-143　2022/01
Publisher: (一社)日本脳神経外傷学会
Real-Time Prediction of Medical Demand and Mental Health Status in Ukraine under Russian Invasion Using Tweet Analysis

Susumu Fujii, Yasuto Kunii, Sayuri Nonaka, Yumiko Hamaie, Mizuki Hino, Shinichi Egawa, Shinichi Kuriyama, Hiroaki Tomita

The Tohoku Journal of Experimental Medicine　2022
Publisher: Tohoku University Medical Press
DOI： 10.1620/tjem.2022.j111 　

ISSN： 0040-8727

eISSN： 1349-3329
母親の妊娠中と産後の心理的ストレス反応と児の問題行動との関連三世代コホート調査

高橋一平, 村上慶子, 五十嵐彩華, 小林美佳, 菊地紗耶, 大柳元, 野田あおい, 大沼ともみ, 松崎芙実子, 上野史彦, 石黒真美, 小原拓, 菅原準一, 富田博秋, 栗山進一

Journal of Epidemiology　32　(Suppl.1)　143-143　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
母親の妊娠中と産後の心理的ストレス反応と児の問題行動との関連三世代コホート調査

高橋一平, 村上慶子, 五十嵐彩華, 小林美佳, 菊地紗耶, 大柳元, 野田あおい, 大沼ともみ, 松崎芙実子, 上野史彦, 石黒真美, 小原拓, 菅原準一, 富田博秋, 栗山進一

Journal of Epidemiology　32　(Suppl.1)　143-143　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
The return of individual genomic results to research participants: design and pilot study of Tohoku Medical Megabank Project

Hiroshi Kawame, Akimune Fukushima, Nobuo Fuse, Fuji Nagami, Yoichi Suzuki, Mika Sakurai-Yageta, Jun Yasuda, Yumi Yamaguchi-Kabata, Kengo Kinoshita, Soichi Ogishima, Takako Takai, Shinichi Kuriyama, Atsushi Hozawa, Naoki Nakaya, Tomohiro Nakamura, Naoko Minegishi, Junichi Sugawara, Kichiya Suzuki, Hiroaki Tomita, Akira Uruno, Tomoko Kobayashi, Yayoi Aizawa, Tomoharu Tokutomi, Kayono Yamamoto, Kinuko Ohneda, Shigeo Kure, Yoko Aoki, Hideki Katagiri, Yasushi Ishigaki, Shojiro Sawada, Makoto Sasaki, Masayuki Yamamoto

Journal of Human Genetics　67　(1)　9-17　2022/01
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s10038-021-00952-8 　

ISSN： 1434-5161

eISSN： 1435-232X
dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project. International-journal

Soichi Ogishima, Satoshi Nagaie, Satoshi Mizuno, Ryosuke Ishiwata, Keita Iida, Kazuro Shimokawa, Takako Takai-Igarashi, Naoki Nakamura, Sachiko Nagase, Tomohiro Nakamura, Naho Tsuchiya, Naoki Nakaya, Keiko Murakami, Fumihiko Ueno, Tomomi Onuma, Mami Ishikuro, Taku Obara, Shunji Mugikura, Hiroaki Tomita, Akira Uruno, Tomoko Kobayashi, Akito Tsuboi, Shu Tadaka, Fumiki Katsuoka, Akira Narita, Mika Sakurai, Satoshi Makino, Gen Tamiya, Yuichi Aoki, Ritsuko Shimizu, Ikuko N Motoike, Seizo Koshiba, Naoko Minegishi, Kazuki Kumada, Takahiro Nobukuni, Kichiya Suzuki, Inaho Danjoh, Fuji Nagami, Kozo Tanno, Hideki Ohmomo, Koichi Asahi, Atsushi Shimizu, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Fuse, Teiji Tominaga, Shigeo Kure, Nobuo Yaegashi, Kengo Kinoshita, Makoto Sasaki, Hiroshi Tanaka, Masayuki Yamamoto

Human genome variation　8　(1)　44-44　2021/12/10

DOI： 10.1038/s41439-021-00175-5 　

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To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an integrated biobank, we developed an integrated database called "dbTMM" that incorporates both the individual cohort/clinical data and the genome/multiomics data of 157,191 participants in the Tohoku Medical Megabank project. To our knowledge, dbTMM is the first database to store individual whole-genome data on a variant-by-variant basis as well as cohort/clinical data for over one hundred thousand participants in a prospective cohort study. dbTMM enables us to stratify our cohort by both genome-wide genetic factors and environmental factors, and it provides a research and development platform that enables prospective analysis of large-scale data from genome cohorts.
Mediating effects of self-stigma and depression on the association between autistic symptoms and recovery in patients with schizophrenia-spectrum disorders: a cross-sectional study

Hiroshi Komatsu, Takashi Ono, Goh Onoguchi, Hiroaki Tomita, Yoshihisa Kakuto

BMC Psychiatry　21　(1)　2021/12
Publisher: Springer Science and Business Media LLC
DOI： 10.1186/s12888-021-03472-z 　

eISSN： 1471-244X

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<title>Abstract</title><sec> <title>Background</title> Several studies have indicated that self-stigma is associated with depressive symptoms and could be a barrier to recovery in patients with schizophrenia-spectrum disorders. More recently, an association between autistic symptoms and self-stigma was found in schizophrenia-spectrum patients. This study aimed to investigate the association between self-stigma, autistic and depressive symptoms, and recovery in patients with schizophrenia. </sec><sec> <title>Methods</title> In total, 105 participants were evaluated using the Autism Spectrum Quotient, the Internalized Stigma of Mental Illness Scale, the Quick Inventory of Depressive Symptomatology, and the Recovery Assessment Scale to investigate autistic symptoms, self-stigma, depressive symptoms, and recovery, respectively. The relationship between self-stigma, autistic symptoms, depressive symptoms, and recovery was assessed using structural equation modeling analysis. </sec><sec> <title>Results</title> Impaired attention switching, one symptom of autism, was found to positively affect stereotype endorsement, which negatively influenced recovery through depressive symptoms. Moreover, problems with communication skills negatively affected recovery through depressive symptoms. Concerning self-stigma, stereotype endorsement and perceived discrimination had a negative effect on recovery through depressive symptoms, whereas stigma resistance had a direct negative effect on recovery. </sec><sec> <title>Conclusions</title> This study may provide meaningful insight into the psychological structure of recovery and could inform effective interventions for patients with schizophrenia-spectrum disorders. This was a cross-sectionally designed study; therefore, further longitudinal studies are needed to identify the causal relationships between self-stigma, autistic and depressive symptoms, and recovery. </sec>
Association between the social isolation and depressive symptoms after the great East Japan earthquake: findings from the baseline survey of the TMM CommCohort study

Yuka Kotozaki, Kozo Tanno, Kiyomi Sakata, Eri Takusari, Kotaro Otsuka, Hiroaki Tomita, Ryohei Sasaki, Nobuyuki Takanashi, Takahiro Mikami, Atsushi Hozawa, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Yasuyuki Taki, Atsushi Shimizu, Jiro Hitomi, Mamoru Satoh, Makoto Sasaki

BMC Public Health　21　(1)　2021/12
Publisher: Springer Science and Business Media LLC
DOI： 10.1186/s12889-021-10896-5 　

eISSN： 1471-2458

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<title>Abstract</title><sec> <title>Background</title> Social isolation and mental health issues have become a severe problem in disaster areas in the Great East Japan Earthquake. This study examined whether the combination of the house damage and social isolation or the combination of the death of family members and social isolation is associated with depressive symptoms among survivors using the baseline study data of the Tohoku Medical Megabank Project Community-Based Cohort Study (TMM CommCohort Study). </sec><sec> <title>Methods</title> We used cross-sectional data from a baseline survey of 48,958 participants (18,423 males, 30,535 females; aged 60.1 ± 11.2 years) to examine the association between social isolation measured by the Lubben social network scale 6 (LSNS-6) and depressive symptoms measured by the Center for Epidemiological Studies-Depressive Scale (CES-D). The presence of social isolation and depressive symptoms was defined by an LSNS-6 score of < 12 and a CES-D score of ≥16, respectively. We performed a logistic regression analysis to determine the multivariable-adjusted odds ratio (95% confidence interval) [AOR (95% CI)] for depressive symptoms according to sex in the social isolation in comparison to without social isolation, and the associations of the combination of the house damage or the death of family members and social isolation and depressive symptoms. </sec><sec> <title>Results</title> Social isolation was significantly associated with depressive symptoms (males: OR = 1.87; 95% CI = 1.72–2.04, females: OR = 2.13; 95% CI = 2.00–2.26). Both males and females respondents with severe house damage and social isolation had a greater risk of depressive symptoms in comparison to those with an undamaged house and without social isolation (males: OR = 3.40; 95% CI = 2.73–4.24, females: OR = 2.92; 95% CI = 2.46–3.46). The risk of depressive symptoms was also higher in both males and females respondents with the death of family members and social isolation in comparison to those without the death of family members and without social isolation (males: OR = 2.18; 95% CI = 1.90–2.50, females: OR = 2.60; 95% CI = 2.35–2.88). </sec><sec> <title>Conclusion</title> The findings suggested that a combination of social isolation and severe house damage and the death of family members caused by a large-scale natural disaster was associated with a higher risk of depressive symptoms although the interaction was not statistically significant. </sec>
Impact of type of reconstructed residence on social participation and mental health of population displaced by disasters. International-journal

Tomomi Suzuki, Tetsuya Akaishi, Harumi Nemoto, Yusuke Utsumi, Moe Seto, Hitomi Usukura, Yasuto Kunii, Yumi Sugawara, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Atsushi Hozawa, Ichiro Tsuji, Tadashi Ishii, Hiroaki Tomita

Scientific reports　11　(1)　21465-21465　2021/11/02

DOI： 10.1038/s41598-021-00913-3 　

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After disasters, people are often forced to reconstruct or move to new residences. This study aimed to reveal the association between the types of reconstructed residences and psychosocial or psychiatric conditions among the population. A total of 1071 adult residents in a coastal town, whose houses were destroyed by the tsunami caused by the Great East Japan Earthquake, enrolled in the study five years after the disaster. The type of reconstructed post-disaster residences (reconstructed on the same site/disaster-recovery public condominium/mass-translocation to higher ground/privately moving to remote areas) and the current psychosocial indicators were investigated. The results revealed that individuals living in public condominiums showed significantly worse scores on the Lubben Social Network Scale-6 (p < 0.0001) and the Center for Epidemiologic Studies Depression Scale (p < 0.0001), and slightly worse scores on the Kessler Psychological Distress Scale (p = 0.035) and the Impact of Event Scale-Revised (p = 0.028). Lower psychosocial indicator scores in the public condominium group were more remarkable in younger adults aged < 65 years. Insomnia evaluated using the Athens Insomnia Scale was not different among the four residential types. In summary, residents moving into disaster-recovery public condominiums are likely to have less social interaction, be more depressed, and may need additional interventions.
東日本大震災被災地域の子どもの睡眠状況の変化とメンタルヘルスとの関連について

松木佑, 吉田弘和, 北川佳奈, 遠藤愛子, 小林奈津子, 菊地紗耶, 本多奈美, 大塚達以, 富田博秋

日本児童青年精神医学会総会抄録集　62回　O-67　2021/11
Publisher: (一社)日本児童青年精神医学会
統合失調症患者のがん終末期における共有意思決定(SDM)を用いた薬剤選択

五十嵐江美, 佐久間篤, 富田博秋

総合病院精神医学　33　(Suppl.)　S-168　2021/11
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
【児童虐待を予防する-産婦人科医,小児科医,精神科医のコラボレーション-】虐待予防のために精神科医ができること周産期メンタルケア外来の実践から

菊地紗耶, 小林奈津子, 本多奈美, 富田博秋

精神神経学雑誌　123　(10)　640-646　2021/10
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
Corrigendum: The delivery of a placenta/fetus with high gonadal steroid production contributes to postpartum depressive symptoms. International-journal

Saya Kikuchi, Natsuko Kobayashi, Zen Watanabe, Chiaki Ono, Takashi Takeda, Hidekazu Nishigori, Nobuo Yaegashi, Takahiro Arima, Kunihiko Nakai, Hiroaki Tomita

Depression and anxiety　38　(10)　1100-1100　2021/10

DOI： 10.1002/da.23216 　
Polygenic risk score for bipolar disorder associates with divergent thinking and brain structures in the prefrontal cortex. International-journal

Hikaru Takeuchi, Ryosuke Kimura, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Izumi Matsudaira, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Sugiko Hanawa, Kunio Iizuka, Atsushi Sekiguchi, Tsuyoshi Araki, Carlos Makoto Miyauchi, Shigeyuki Ikeda, Kohei Sakaki, Kelssy H Dos S Kawata, Takayuki Nozawa, Susumu Yokota, Daniele Magistro, Tadashi Imanishi, Ryuta Kawashima

Human brain mapping　42　(18)　6028-6037　2021/09/29

DOI： 10.1002/hbm.25667 　

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It has been hypothesized that a higher genetic risk of bipolar disorder (BD) is associated with greater creativity. Given the clinical importance of bipolar disorder and the importance of creativity to human society and cultural development, it is essential to reveal their associations and the neural basis of the genetic risk of bipolar disorder to gain insight into its etiology. However, despite the previous demonstration of the associations of polygenic risk score (PRS) of BD and creative jobs, the associations of BD-PRS and creativity measured by the divergent thinking (CMDT) and regional gray matter volume (rGMV) as well as regional white matter volume (rWMV) have not been investigated. Using psychological analyses and whole-brain voxel-by-voxel analyses, we examined these potential associations in 1558 young, typically developing adult students. After adjusting for confounding variables and multiple comparisons, a greater BD-PRS was associated with a greater total CMDT fluency score, and a significant relationship was found in fluency subscores. A greater BD-PRS was also associated with lower total mood disturbance. Neuroimaging analyses revealed that the BD-PRS was associated with greater rGMV in the right inferior frontal gyrus, which is a consistently affected area in BD, as well as a greater rWMV in the left middle frontal gyrus, which has been suggested to play a central role in the increased creativity associated with the risk of BD with creativity. These findings suggest a relationship between the genetic risk of BD and CMDT and prefrontal cortical structures among young educated individuals.
The influence of NRXN1 on systemizing and the brain structure in healthy adults

Yuka Shiota, Izumi Matsudaira, Hikaru Takeuchi, Chiaki Ono, Hiroaki Tomita, Ryuta Kawashima, Yasuyuki Taki

Brain Imaging and Behavior　16　(2)　692-701　2021/09/16
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s11682-021-00530-8 　

ISSN： 1931-7557

eISSN： 1931-7565
One-year trajectories of postpartum depressive symptoms and associated psychosocial factors: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Saya Kikuchi, Keiko Murakami, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Natsuko Kobayashi, Junichi Sugawara, Masayuki Yamamoto, Nobuo Yaegashi, Shinichi Kuriyama, Hiroaki Tomita

Journal of affective disorders　295　632-638　2021/09/04

DOI： 10.1016/j.jad.2021.08.118 　

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BACKGROUND: Trajectories of postpartum depressive symptoms up to 1 year after childbirth and the related risk factors remain unclear. Accordingly, this study aimed to examine the 1-year trajectories of postpartum depressive symptoms and their associated risk factors. METHODS: A total of 22,493 pregnant women were recruited between July 2013 and September 2016 in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Japan. Among them, 11,668 women with no missing data were included in the analyses. Depressive symptoms were assessed at 1 month and 1 year postpartum using the Edinburgh Postnatal Depression Scale. Multinominal logistic regression analysis was conducted after adjusting for covariates. RESULTS: The prevalence of depression was 13.9% at 1 month and 12.9% at 1 year postpartum. We identified four depression trajectories, i.e., "persistent (depressed throughout the 1 year postpartum)" (6.0%), "recovered (depressed at 1 month postpartum and recovered within a year)" (7.9%), "late-onset (became depressed after 1 month postpartum)" (6.8%), and "resilient (not depressed throughout 1 year postpartum)" (79.2%). Psychological distress during pregnancy was significantly associated with all trajectories (persistent: odds ratio [OR]=10.24, 95% confidence interval (CI)=8.40-12.48; recovered: OR=3.78, 95%CI=3.28-4.36; and late-onset: OR=3.96, 95%CI=3.40-4.62). LIMITATIONS: Postpartum depression was evaluated only by a self-administered questionnaire and the dropout rate was not neglectable. CONCLUSIONS: This study highlighted the high prevalence of depressive symptoms at 1 year postpartum and found that half of the depressive symptoms at 1 year were late-onset. The findings suggest the necessity of long-term follow-up (up to 1 year) for perinatal mental health.
【母と子のメンタルヘルスと心理社会的支援多職種連携で妊産婦を支える】知識編各職種の立場から出産前後の性ホルモン変化と産後うつとの関連精神科医師の立場から

菊地紗耶, 小林奈津子, 富田博秋

ペリネイタルケア　40　(9)　856-860　2021/09
Publisher: (株)メディカ出版
ISSN： 0910-8718
がん終末期において薬物動態に配慮を要した統合失調症の2例

五十嵐江美, 佐久間篤, 和田努, 佐藤博俊, 富田博秋

精神神経学雑誌　(2021特別号)　S543-S543　2021/09
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
運動処方(FITT)の観点からみる健康意識を伴った歩行のあり方と精神的健康の関連

内海裕介, 臼倉瞳, 瀬戸萌, 佐久間篤, 國井泰人, 富田博秋

精神神経学雑誌　(2021特別号)　S599-S599　2021/09
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
東日本大震災発災後9年間における被災地域住民の心理的苦痛および不眠症状の変化の特徴

臼倉瞳, 内海裕介, 瀬戸萌, 佐久間篤, 國井泰人, 富田博秋

精神神経学雑誌　(2021特別号)　S563-S563　2021/09
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
あらゆる脅威に対するメンタルヘルス対策:自然災害、人為災害からテロまで新型コロナウイルス感染症(COVID-19)流行下におけるメンタルヘルス対策

國井泰人, 臼倉瞳, 瀬戸萌, 富田博秋

精神神経学雑誌　(2021特別号)　S478-S478　2021/09
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
New long stay患者の包括的な退院困難要因に関する調査予備的検討

小松浩, 大野高志, 米田芳則, 石田雄介, 槙貴浩, 大場綾希子, 鈴木明, 森康子, 庄司盟子, 坂本洋生, 尾崎伸也, 海老名貴幸, 高橋幸子, 本間竜太, 富田博秋, 角藤芳久

精神神経学雑誌　(2021特別号)　S570-S570　2021/09
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
White matter volume not associated with hallucinations in clinical high risk and first-episode psychosis: A voxel-based morphometry study. International-journal

Yutaro Sato, Atsushi Sakuma, Noriyuki Ohmuro, Masahiro Katsura, Koichi Abe, Kazuho Tomimoto, Kunio Iizuka, Fumiaki Ito, Hiroaki Tomita, Kazunori Matsumoto

Psychiatry and clinical neurosciences　75　(9)　299-301　2021/09

DOI： 10.1111/pcn.13284 　
The association between psychological distress and risk of incident functional disability in elderly survivors after the Great East Japan Earthquake: The mediating effect of lifestyle and bodily pain. International-journal

Toshimasa Sone, Yumi Sugawara, Fumiya Tanji, Naoki Nakaya, Hiroaki Tomita, Ichiro Tsuji

Journal of affective disorders　295　552-558　2021/08/31

DOI： 10.1016/j.jad.2021.08.068 　

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BACKGROUND: We previously reported that psychological distress was associated with an increased risk of functional disability. However, the mechanism of the association remains unclear. Our aim was to estimate the mediating effect of lifestyle and bodily pain on the association among elderly survivors after the Great East Japan Earthquake. METHODS: The study population comprised 1037 residents aged ≥ 65 years. The baseline surveys (exposure and mediators) were conducted in 2011. We classified participants into three categories according to their Kessler 6 score (low: 0-9, moderate: 10-12, and high: 13-24) and defined functional disability as certification for long-term care insurance in Japan. The Cox proportional hazards model was used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for incident functional disability according to Kessler 6 categories and explored the mediating effects of lifestyle and bodily pain on the association. RESULTS: During approximately 8 years of follow-up, we documented 271 incident cases of functional disability. Compared with those in the low distress group, the multivariate adjusted HR for incident functional disability was 1.95 (95% CI 1.21-3.13) for those in the high distress group. Time spent walking, going out, and bodily pain significantly mediated the association between psychological distress and incident functional disability by 10.2%, 10.5%, and 10.3% for the high distress group, respectively. LIMITATIONS: We did not consider unmeasured confounders and use of appropriate medication. CONCLUSIONS: The evaluation and treatment of bodily pain as well as promotion of active lifestyle would be important for preventing disability among disaster survivors.
Five-Year Psychosocial Impact of Living in Postdisaster Prefabricated Temporary Housing. International-journal

Tetsuya Akaishi, Tomomi Suzuki, Harumi Nemoto, Yusuke Utsumi, Moe Seto, Hitomi Usukura, Yasuto Kunii, Yumi Sugawara, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Atsushi Hozawa, Ichiro Tsuji, Tadashi Ishii, Hiroaki Tomita

Disaster medicine and public health preparedness　16　(5)　1-9　2021/08/20

DOI： 10.1017/dmp.2021.214 　

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OBJECTIVE: This study aims to evaluate the long-term impact of living in postdisaster prefabricated temporary housing on social interaction activities and mental health status. METHODS: A total of 917 adult residents in a coastal town, whose residences were destroyed by the tsunami caused by the Great East Japan Earthquake (GEJE), were enrolled for the assessment held 5 y after the disaster. They answered questions about their experience and consequence of living in prefabricated temporary housing after the disaster. Their present scores on 5 types of self-reported measures regarding the psychosocial or psychiatric status and their present and recalled social interaction activities were cross-sectionally collected. RESULTS: A total of 587 (64.0%) participants had a history of living in prefabricated temporary housing, while the other 330 (36.0%) had not. The prevalence of social interaction activities significantly decreased after the GEJE. However, the experience of living in prefabricated temporary housing did not adversely affect the subsequent social interaction activities or mental conditions of the participants 5 y after the disaster. CONCLUSIONS: Living in postdisaster prefabricated temporary housing may not negatively impact subsequent psychosocial conditions or social interaction activities 5 y later.
The mental health problems of public health center staff during the COVID-19 pandemic in Japan

Hitomi Usukura, Moe Seto, Yasuto Kunii, Akira Suzuki, Ken Osaka, Hiroaki Tomita

Asian Journal of Psychiatry　61　102676-102676　2021/07
Publisher: Elsevier BV
DOI： 10.1016/j.ajp.2021.102676 　

ISSN： 1876-2018
Five-year Psychosocial Impact of Living in Post-Disaster Prefabricated Temporary Housing. International-journal

Tetsuya Akaishi, Tomomi Suzuki, Harumi Nemoto, Yusuke Utsumi, Moe Seto, Hitomi Usukura, Yasuto Kunii, Yumi Sugawara, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Atsushi Hozawa, Ichiro Tsuji, Tadashi Ishii, Hiroaki Tomita

Disaster medicine and public health preparedness　1-31　2021/06/23

DOI： 10.1017/dmp.2021.212 　

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OBJECTIVE: This study aims to evaluate the long-term impact of living in post-disaster prefabricated temporary housing on social interaction activities and mental health status. METHODS: A total of 917 adult residents in a coastal town, whose residences were destroyed by the tsunami caused by the Great East Japan Earthquake (GEJE), were enrolled for the assessment held five years after the disaster. They answered questions about their experience and consequence of living in prefabricated temporary housing after the disaster. Their present scores on five types of self-reported measures regarding the psychosocial or psychiatric status and their present and recalled social interaction activities were cross-sectionally collected. RESULTS: A total of 587 (64.0%) participants had a history of living in prefabricated temporary housing, while the other 330 (36.0%) had not. The prevalence of social interaction activities significantly decreased after the GEJE. However, the experience of living in prefabricated temporary housing did not adversely affect the subsequent social interaction activities or mental conditions of the participants five years after the disaster. CONCLUSIONS: Living in post-disaster prefabricated temporary housing may not negatively impact subsequent psychosocial conditions or social interaction activities five years later.
【日本の周産期メンタルヘルス事情update】産科医のための周産期メンタルヘルスケア入門

菊地紗耶, 小林奈津子, 木村涼子, 富田博秋

産婦人科の実際　70　(6)　635-640　2021/06
Publisher: 金原出版(株)
ISSN： 0558-4728
鑑別に苦慮した老年期精神障害の3例

小野口豪, 小松浩, 橘高一, 富田博秋

精神神経学雑誌　123　(6)　367-367　2021/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
レビー小体型認知症と症候性てんかんによる意識障害が重畳していたと考えられる症例

山内昂也, 佐久間篤, 田坂有香, 小松浩, 富田博秋

精神神経学雑誌　123　(6)　371-371　2021/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
【双極性障害診療を極める】妊産婦双極性障害における治療継続の方法・気をつけること

菊地紗耶, 小林奈津子, 本多奈美, 富田博秋

精神科治療学　36　(5)　569-574　2021/05
Publisher: (株)星和書店
ISSN： 0912-1862
Tumor necrosis factor α negatively regulates the retrieval and reconsolidation of hippocampus-dependent memory. International-journal

Shohei Takahashi, Hotaka Fukushima, Zhiqian Yu, Hiroaki Tomita, Satoshi Kida

Brain, behavior, and immunity　94　79-88　2021/05

DOI： 10.1016/j.bbi.2021.02.033 　

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Neural inflammation is associated with cognitive decline, especially learning and memory. Tumor necrosis factor α (TNFα) is a major cytokine generated during neuroinflammation. Previous studies indicated that TNFα impairs hippocampus-dependent memory including contextual fear and spatial memories. However, it is unknown which memory processes are impaired by TNFα. Here, we show that TNFα blocked the retrieval and reconsolidation of contextual fear and spatial memories. Micro-infusion of TNFα into the dorsal hippocampus at 6-18 h before retrieval impaired the retrieval of contextual fear memory, although micro-infusion before contextual fear conditioning had no effect on memory formation. Interestingly, hippocampal TNFα micro-infusion before memory retrieval decreased freezing responses, even at 24 h after retrieval, suggesting that TNFα impairs the reconsolidation of contextual fear memory. Similarly, hippocampal TNFα micro-infusion impaired the retrieval and reconsolidation of spatial memory in the Morris water maze. Consistent with these observations, hippocampal TNFα micro-infusion before retrieval blocked the induction of c-fos expression in the hippocampus, which is a marker of neural activation, in response to the retrieval of contextual fear memory. Collectively, our findings indicate that TNFα negatively regulates the retrieval and reconsolidation of hippocampus-dependent memory.
The delivery of a placenta/fetus with high gonadal steroid production contributes to postpartum depressive symptoms. International-journal

Saya Kikuchi, Natsuko Kobayashi, Zen Watanabe, Chiaki Ono, Takashi Takeda, Hidekazu Nishigori, Nobuo Yaegashi, Takahiro Arima, Kunihiko Nakai, Hiroaki Tomita

Depression and anxiety　38　(4)　422-430　2021/04

DOI： 10.1002/da.23134 　

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BACKGROUND: A correlation between gonadal steroids and depressive symptoms during the perinatal period has long been suggested; however, the underlying mechanism for this relationship remains unclear. METHODS: This study was designed to examine the correlation between gonadal steroid concentrations of umbilical cord blood and postpartum depressive symptoms as well as longitudinal alterations in maternal plasma gonadal steroid concentrations among 204 perinatal women. The levels of postpartum depressive state at 1 month postpartum were evaluated using the Edinburgh Postnatal Depression Scale. RESULTS: Umbilical progesterone, estradiol, and testosterone levels were significantly higher in infants delivered by depressed mothers (870.7 ± 281.7 ng/ml, 8607.7 ± 4354.6 pg/ml, and 2.5 ± 0.9 ng/ml, respectively) than those delivered by nondepressed mothers (741.3 ± 324.0 ng/ml, 5221.9 ± 3416.3 pg/ml, and 2.1 ± 0.6 ng/ml, p < .01, p < .05, and p < .05, respectively). Postpartum plasma progesterone levels of depressed mothers (3.5 ± 3.1 ng/ml) measured in the early postpartum period were significantly lower than those of nondepressed mothers (9.1 ± 9.7 ng/ml, p < .01). The decrease in progesterone from mid-pregnancy to the early postpartum period was significantly higher in depressed mothers than in nondepressed mothers. Subgroup analyses specific to primiparas or multiparas indicated that a significant drop of progesterone was seen only in primiparas. CONCLUSION: The current study suggests that the delivery of a placenta/fetus with high gonadal steroid production may cause a wider range of fluctuations in maternal plasma gonadal steroid concentrations, which may be concurrent with postpartum depressive symptoms.
Association Between OLIG2 Gene SNP rs1059004 and Negative Self-Schema Constructing Trait Factors Underlying Susceptibility to Depression

Hiroshi Komatsu, Hikaru Takeuchi, Chiaki Ono, Zhiqian Yu, Yoshie Kikuchi, Yoshihisa Kakuto, Shunichi Funakoshi, Takashi Ono, Ryuta Kawashima, Yasuyuki Taki, Hiroaki Tomita

Frontiers in Psychiatry　12　2021/03/08
Publisher: Frontiers Media SA
DOI： 10.3389/fpsyt.2021.631475 　

eISSN： 1664-0640

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Recent evidence has indicated that the disruption of oligodendrocytes may be involved in the pathogenesis of depression. Genetic factors are likely to affect trait factors, such as characteristics, rather than state factors, such as depressive symptoms. Previously, a negative self-schema had been proposed as the major characteristic of constructing trait factors underlying susceptibility to depression. Thus, the association between a negative self-schema and the functional single nucleotide polymorphism (SNP) rs1059004 in the <italic>OLIG2</italic> gene, which influences <italic>OLIG2</italic> gene expression, white matter integrity, and cerebral blood flow, was evaluated. A total of 546 healthy subjects were subjected to genotype and psychological evaluation using the Beck Depression Inventory-II (BDI-II) and the Brief Core Schema Scale (BCSS). The rs1059004 SNP was found to be associated with the self-schema subscales of the BCSS and scores on the BDI-II in an allele dose-dependent manner, and to have a predictive impact on depressive symptoms via a negative-self schema. The results suggest the involvement of a genetic factor regulating oligodendrocyte function in generating a negative-self schema as a trait factor underlying susceptibility to depression.
Machine learning to reveal hidden risk combinations for the trajectory of posttraumatic stress disorder symptoms

Yuta Takahashi, Kazuki Yoshizoe, Masao Ueki, Gen Tamiya, Yu Zhiqian, Yusuke Utsumi, Atsushi Sakuma, Koji Tsuda, Atsushi Hozawa, Ichiro Tsuji, Hiroaki Tomita

Scientific Reports　10　(1)　2020/12
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s41598-020-78966-z 　

eISSN： 2045-2322

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<title>Abstract</title>The nature of the recovery process of posttraumatic stress disorder (PTSD) symptoms is multifactorial. The Massive Parallel Limitless-Arity Multiple-testing Procedure (MP-LAMP), which was developed to detect significant combinational risk factors comprehensively, was utilized to reveal hidden combinational risk factors to explain the long-term trajectory of the PTSD symptoms. In 624 population-based subjects severely affected by the Great East Japan Earthquake, 61 potential risk factors encompassing sociodemographics, lifestyle, and traumatic experiences were analyzed by MP-LAMP regarding combinational associations with the trajectory of PTSD symptoms, as evaluated by the Impact of Event Scale-Revised score after eight years adjusted by the baseline score. The comprehensive combinational analysis detected 56 significant combinational risk factors, including 15 independent variables, although the conventional bivariate analysis between single risk factors and the trajectory detected no significant risk factors. The strongest association was observed with the combination of short resting time, short walking time, unemployment, and evacuation without preparation (adjusted <italic>P</italic> value = 2.2 × 10⁻⁴, and raw <italic>P</italic> value = 3.1 × 10⁻⁹). Although short resting time had no association with the poor trajectory, it had a significant interaction with short walking time (<italic>P</italic> value = 1.2 × 10⁻³), which was further strengthened by the other two components (<italic>P</italic> value = 9.7 × 10⁻⁵). Likewise, components that were not associated with a poor trajectory in bivariate analysis were included in every observed significant risk combination due to their interactions with other components. Comprehensive combination detection by MP-LAMP is essential for explaining multifactorial psychiatric symptoms by revealing the hidden combinations of risk factors.
Experiences of perinatal women and public healthcare providers in a community affected by the great east Japan earthquake and tsunami: Concerns that must be considered for the mental healthcare of perinatal women in postdisaster settings

Natsuko Kobayashi, Harumi Nemoto, Moe Seto, Shosuke Sato, Saya Kikuchi, Nami Honda, Tomomi Suzuki, Kineko Sato, Junichi Sugawara, Kiyoshi Ito, Ryoma Kayano, Norio Ozaki, Charles W. Beadling, Ilan Kelman, Fumihiko Imamura, Hiroo Matsuoka, Hiroaki Tomita

International Journal of Disaster Risk Reduction　51　2020/12

DOI： 10.1016/j.ijdrr.2020.101767 　

ISSN： 2212-4209
Machine learning for effectively avoiding overfitting is a crucial strategy for the genetic prediction of polygenic psychiatric phenotypes Peer-reviewed

Yuta Takahashi, Masao Ueki, Gen Tamiya, Soichi Ogishima, Kengo Kinoshita, Atsushi Hozawa, Naoko Minegishi, Fuji Nagami, Kentaro Fukumoto, Kotaro Otsuka, Kozo Tanno, Kiyomi Sakata, Atsushi Shimizu, Makoto Sasaki, Kenji Sobue, Shigeo Kure, Masayuki Yamamoto, Hiroaki Tomita

Translational Psychiatry　10　(1)　2020/12
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s41398-020-00957-5 　

eISSN： 2158-3188
Improved metabolomic data-based prediction of depressive symptoms using nonlinear machine learning with feature selection Peer-reviewed

Yuta Takahashi, Masao Ueki, Makoto Yamada, Gen Tamiya, Ikuko N. Motoike, Daisuke Saigusa, Miyuki Sakurai, Fuji Nagami, Soichi Ogishima, Seizo Koshiba, Kengo Kinoshita, Masayuki Yamamoto, Hiroaki Tomita

Translational Psychiatry　10　(1)　2020/12/01

DOI： 10.1038/s41398-020-0831-9 　

eISSN： 2158-3188
【新型コロナウイルス感染症(COVID-19)と精神科病院】宮城県精神科医療機関新型コロナウイルス感染症対策ネットワークにおける対策指針策定の経緯と意義コロナ禍が精神医療にもたらした教訓

富田博秋, 佐藤博俊, 角藤芳久, 國井泰人, 佐久間篤, 牧野祐子, 児玉栄一, 徳田浩一, 鈴木陽, 吉田眞紀子, 賀来満夫, 押谷仁, 小坂健

日本精神科病院協会雑誌　39　(11)　1125-1130　2020/11
Publisher: (公社)日本精神科病院協会
ISSN： 1347-4103
【パンデミックと精神医療・精神科リハビリテーション】求められる精神保健医療福祉・自治体ネットワークの再編

富田博秋, 國井泰人

精神障害とリハビリテーション　24　(2)　166-170　2020/11
Publisher: 日本精神障害者リハビリテーション学会
ISSN： 1343-0386
最近の多様化する災害と総合病院精神医学の対応について災害医療に従事した病院職員に対するメンタルヘルス支援縦断調査からみえてきた課題

佐久間篤, 内海裕介, 臼倉瞳, 五十嵐江美, 田坂有香, 高橋雄太, 菊地紗耶, 本多奈美, 國井泰人, 富田博秋

総合病院精神医学　32　(Suppl.)　S-68　2020/11
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
【新型コロナウイルス感染症(COVID-19)と精神科病院】宮城県精神科医療機関新型コロナウイルス感染症対策ネットワークにおける対策指針策定の経緯と意義コロナ禍が精神医療にもたらした教訓

富田博秋, 佐藤博俊, 角藤芳久, 國井泰人, 佐久間篤, 牧野祐子, 児玉栄一, 徳田浩一, 鈴木陽, 吉田眞紀子, 賀来満夫, 押谷仁, 小坂健

日本精神科病院協会雑誌　39　(11)　1125-1130　2020/11
Publisher: (公社)日本精神科病院協会
ISSN： 1347-4103
Impact of the Great East Japan Earthquake on the Employment Status and Mental Health Conditions of Affected Coastal Communities

Mitsuaki Katayanagi, Moe Seto, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Yumi Sugawara, Akira Kodaka, Yusuke Utsumi, Hitomi Usukura, Yasuto Kunii, Atsushi Hozawa, Ichiro Tsuji, Hiroaki Tomita

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH　17　(21)　2020/11

DOI： 10.3390/ijerph17218130 　

eISSN： 1660-4601
全身状態悪化に伴う好中球減少症から回復後に、クロザピンを再投与できた統合失調症症例

菊地佑樹, 佐久間篤, 若栗碧子, 富田博秋

総合病院精神医学　32　(4)　417-422　2020/10
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
東日本大震災被災者の居住環境の変化による他者との交流習慣・メンタルヘルスへの影響

鈴木智美, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 中谷直樹, 寳澤篤, 辻一郎, 富田博秋

日本公衆衛生学会総会抄録集　79回　415-415　2020/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
Sex-Dependent Effects of the APOE ɛ4 Allele on Behavioral Traits and White Matter Structures in Young Adults

Hikaru Takeuchi, Hiroaki Tomita, Ryan Browne, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Yuko Sassa, Ryuta Kawashima

Cerebral Cortex　31　(1)　672-680　2020/09/21
Publisher: Oxford University Press (OUP)
DOI： 10.1093/cercor/bhaa251 　

ISSN： 1047-3211

eISSN： 1460-2199

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<title>Abstract</title> The APOE ɛ4 allele is associated with a risk of Alzheimer’s disease in the elderly, with the association being pronounced in females. Conversely, findings of the effects of the APOE ɛ4 allele in young adults are mixed. Here, we investigated the sex–genotype interaction effects of the APOE ɛ4 allele on cognitive functions as well as brain structures among 1258 young adults. After adjusting for multiple comparisons, there were significant effects of the interaction between sex and the number of APOE ɛ4 allele on some speed tasks (e.g., simple processing speed tasks and the reverse Stroop task) as well as on regional white matter volume (rWMV). The observed sex–genotype interaction conferred better cognitive performance and greater rWMV in the anterior frontal and precentral white matter areas in females having more APOE ɛ4 alleles and reduced rWMV in the same areas in male having more APOE ɛ4 alleles. These findings support the long-debated antagonistic pleiotropic effects of the APOE ɛ4 allele in females.
児童虐待を予防する-産婦人科医、小児科医、精神科医のコラボレーション- 虐待予防のために精神科医ができること周産期メンタルケア外来の実践から

菊地紗耶, 小林奈津子, 本多奈美, 富田博秋

精神神経学雑誌　(2020特別号)　S487-S487　2020/09
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
周産期メンタルヘルスの最前線産後うつ病の特徴と治療

小林奈津子, 菊地紗耶, 本多奈美, 富田博秋

精神神経学雑誌　(2020特別号)　S538-S538　2020/09
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
【周産期メンタルヘルスの今】東北メディカル・メガバンク事業出生コホートを起点とした産後うつ病研究

菊地紗耶, 小林奈津子, 小野千晶, 割田紀子, 村上慶子, 小原拓, 長神風二, 栗山進一, 富田博秋

精神医学　62　(9)　1245-1251　2020/09
Publisher: (株)医学書院
ISSN： 0488-1281

eISSN： 1882-126X
周産期の統合失調症に対する抗精神病薬投与と代謝性合併症

小林奈津子, 菊地紗耶, 齋藤昌利, 本多奈美, 富田博秋

精神神経学雑誌　(2020特別号)　S441-S441　2020/09
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
個別化精神医療確立に向けたバイオバンク整備の展望バイオバンク情報への機械学習の導入

高橋雄太, 植木優夫, 田宮元, 富田博秋

精神神経学雑誌　(2020特別号)　S247-S247　2020/09
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
Ultra High Risk者を対象とした精神病発症予測因子の検討睡眠関連パラメータとサイトカインの計測

北村真吾, 盛本翼, 岸本直子, 田形弘実, 根本隆洋, 樋口悠子, 大島勇人, 加藤隆郎, 三島和夫, 石間環, 橋本謙二, 大西隆, 松木佑, 桂雅宏, 富田博秋, 内村直尚, 鈴木道雄, 水野雅文, 岸本年史, 住吉太幹, 中込和幸

精神神経学雑誌　(2020特別号)　S307-S307　2020/09
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
Trajectories for Post-traumatic Stress Disorder Symptoms Among Local Disaster Recovery Workers Following the Great East Japan Earthquake: Group-based Trajectory Modeling

Atsushi Sakuma, Ikki Ueda, Wataru Shoji, Hiroaki Tomita, Hiroo Matsuoka, Kazunori Matsumoto

Journal of Affective Disorders　274　742-751　2020/09/01

DOI： 10.1016/j.jad.2020.05.152 　

ISSN： 0165-0327

eISSN： 1573-2517
Onset and remission of common mental disorders among adults living in temporary housing for three years after the triple disaster in Northeast Japan: comparisons with the general population. International-journal

Norito Kawakami, Maiko Fukasawa, Kiyomi Sakata, Ruriko Suzuki, Hiroaki Tomita, Harumi Nemoto, Seiji Yasumura, Hirooki Yabe, Naoko Horikoshi, Maki Umeda, Yuriko Suzuki, Haruki Shimoda, Hisateru Tachimori, Tadashi Takeshima, Evelyn J Bromet

BMC public health　20　(1)　1271-1271　2020/08/20

DOI： 10.1186/s12889-020-09378-x 　

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BACKGROUND: People living in temporary housing for long periods after a disaster are at risk of poor mental health. This study investigated the post-disaster incidence and remission of common mental disorders among adults living in temporary housing for the 3 years following the 2011 Great East Japan Earthquake. METHODS: Three years after the disaster, face-to-face interviews were conducted with 1089 adult residents living in temporary housing in the disaster area, i.e., the shelter group, and a random sample of 852 community residents from non-disaster areas of East Japan. The World Health Organization Composite International Diagnostic Interview was used to diagnose DSM-IV mood, anxiety, and alcohol use disorders. Information on demographic variables and disaster experiences was also collected. RESULTS: Response rates were 49 and 46% for the shelter group and the community residents, respectively. The incidence of mood/anxiety disorder in the shelter group was elevated only in the first year post-disaster compared to that of the general population. The rate of remission for mood and anxiety disorders was significantly lower in the shelter group than in the community residents. The proportion seeking medical treatment was higher in the shelter group. CONCLUSIONS: The onset of common mental disorders increased in the first year, but then levelled off in the following years among residents in temporary housing after the disaster. Remission from incident post-disaster mental disorders was slower in the shelter group than in the general population. Post-disaster mental health service could consider the greater incidence in the first year and prolonged remission of mental disorders among survivors with a long-term stay in temporary housing after a disaster.
妊婦心拍変異性情報、睡眠状況と情緒調節の関連性研究(The correlations between the heart rate variability information, sleep conditions and emotions regulation among individuals with pregnant women)

Li Xue, 兪志前, 小野千晶, 富田博秋

日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集　50回・42回・4回　183-183　2020/08
Publisher: 日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会
予測符号化理論に基づくニューラルネットワークを用いた自閉スペクトラム症における表情認知特性に関する検討

高橋雄太, 村田真悟, 出井勇人, 富田博秋, 山下祐一

日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集　50回・42回・4回　183-183　2020/08
Publisher: 日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会
産後うつ病の予測と予防のための血漿サイトカインレベルの検証

兪志前, 小野千晶, 小原拓, 菊地沙耶, 小林奈津子, 菅原準一, 栗山進一, 山本雅之, 八重樫伸生, 富田博秋

日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集　50回・42回・4回　195-195　2020/08
Publisher: 日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会
産後うつ病の予測と予防のための血漿サイトカインレベルの検証

兪志前, 小野千晶, 小原拓, 菊地沙耶, 小林奈津子, 菅原準一, 栗山進一, 山本雅之, 八重樫伸生, 富田博秋

日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集　50回・42回・4回　195-195　2020/08
Publisher: 日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会
The Impact of Health Consciousness on the Association Between Walking Durations and Mental Health Conditions After a Disaster: a Cross-Sectional Study. International-journal Peer-reviewed

Yusuke Utsumi, Harumi Nemoto, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Tomomi Suzuki, Moe Seto, Mitsuaki Katayanagi, Junko Okuyama, Atsushi Sakuma, Nami Honda, Yumi Sugawara, Halley Kaye-Kauderer, Yuta Takahashi, Akemi Kayama, Yoshihisa Kakuto, Masahiro Kohzuki, Atsushi Hozawa, Ichiro Tsuji, Hiroaki Tomita

Sports medicine - open　6　(1)　30-30　2020/07/16

DOI： 10.1186/s40798-020-00259-6 　

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BACKGROUND: In communities affected by a disaster, walking can be a feasible form of physical exercise to improve physical and mental health conditions. However, there is limited evidence to support relationships between walking habits and mental health conditions in post-disaster settings. Cross-sectional epidemiological data obtained from a questionnaire survey (conducted in October 2017) of a community affected by the 2011 Great East Japan Earthquake (GEJE) was analyzed to evaluate the relationships. METHODS: Participants included individuals over 20 years of age (N = 718) from Shichigahama town in Miyagi prefecture, whose houses were significantly damaged by the GEJE. Their mental health conditions were assessed by the Kessler Psychological Distress Scale (K6), the Center for Epidemiologic Studies Depression Scale (CES-D), and the Impact of Event Scale-Revised (IES-R). Additionally, the questionnaire asked the participants spent duration walking on average and their walking purpose by the following items: (1) longer than 60 min per day, (2) between 30 and 60 min per day, or (3) less than 30 min per day, and whether they walked to maintain healthy living habits (health-conscious walkers) or merely for transportation without considering health consequences (non-health-conscious walkers). These information and mental health indicators were analyzed using analysis of covariance (ANCOVA). RESULTS: Among the three walking duration groups of health-conscious walkers, there were significant differences in CES-D and K6 scores (p = 0.01 and p = 0.04), but not in IES-R scores, considering age, gender, and alcohol drinking habits as covariates. CES-D score was significantly higher among short walkers (p = 0.004). Among the three walking duration groups of non-health-conscious walkers, there were significant differences in avoidance symptoms, the subdomain of IES-R (p = 0.01), but not in CES-D, K6, and total IES-R scores, considering the variants. CONCLUSION: Our study suggests that walking durations may positively affect mood, but not PTSR, only when walking is performed with the purpose of maintaining healthy living habits. Walking durations were negatively associated with avoidance symptoms among non-health-conscious walkers in the community affected by the GEJE, indicating that the disaster may have had a long-lasting impact on walking habits.
【妊娠・出産と精神科臨床アップデート】授乳期の精神科薬物療法

菊地紗耶, 小林奈津子, 小原拓, 本多奈美, 富田博秋

臨床精神医学　49　(7)　907-915　2020/07
Publisher: (株)アークメディア
ISSN： 0300-032X
Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project

Akito Tsuboi, Hiroyuki Matsui, Naru Shiraishi, Takahisa Murakami, Akihito Otsuki, Junko Kawashima, Tomomi Kiyama, Toru Tamahara, Maki Goto, Shihoko Koyama, Junichi Sugawara, Eiichi N. Kodama, Hirohito Metoki, Atsushi Hozawa, Shinichi Kuriyama, Hiroaki Tomita, Masahiro Kikuya, Naoko Minegishi, Kichiya Suzuki, Seizo Koshiba, Gen Tamiya, Nobuo Fuse, Yuichi Aoki, Takako Takai-Igarashi, Soichi Ogishima, Tomohiro Nakamura, Mika Sakurai-Yageta, Fuji Nagami, Kengo Kinoshita, Shigeo Kure, Ritsuko Shimizu, Keiichi Sasaki, Masayuki Yamamoto

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　251　(2)　97-115　2020/06

DOI： 10.1620/tjem.251.97 　

ISSN： 0040-8727

eISSN： 1349-3329
Effect of the interaction between BDNF Val66Met polymorphism and daily physical activity on mean diffusivity. International-journal Peer-reviewed

Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Brain imaging and behavior　14　(3)　806-820　2020/06

DOI： 10.1007/s11682-018-0025-8 　

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Numerous studies have reported that the Met allele of the brain-derived neurotrophic factor (BDNF) gene polymorphism reduces neural plasticity. A reduction in mean diffusivity (MD) in diffusion tensor imaging (DTI) characteristically reflects the neural plasticity that involves increased tissue components. In this study, we revealed that the number of Met-BDNF alleles was negatively associated with MD throughout the whole-brain gray and white matter areas of 743 subjects using DTI and whole-brain multiple regression analyses. Within the same sample, the region of interest analysis revealed that the number of Met-BDNF alleles significantly and positively correlated with the mean FA value in the body of the corpus callosum. In addition, we observed interaction effects between BDNF Val66Met polymorphism and daily physical activity levels on MD, but not FA, in significant clusters of the bilateral hemisphere (n = 577 subjects). Post-hoc multiple regression analyses revealed that after correcting for confounding variables, there was a significant negative correlation between the physical activity level and mean MD of the whole brain in the Val/Val group [standardized partial regression coefficient (β) = -0.196, P = 0.005, t = -2.825], but not in the Val/Met (β = 0.050, P = 0.412, t = 0.822) and Met/Met groups (β = 0.092, P = 0.382, t = 0.878). These results underscore the importance of the interaction between physical activity and the BDNF Val66Met polymorphism, which affects the plasticity of neural mechanisms.
Ethnicity-Dependent Effects of Schizophrenia Risk Variants of the OLIG2 Gene on OLIG2 Transcription and White Matter Integrity Peer-reviewed

Hiroshi Komatsu, Hikaru Takeuchi, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Kunio Iizuka, Yuji Takano, Yoshihisa Kakuto, Shunichi Funakoshi, Takashi Ono, Junko Ito, Yasuto Kunii, Mizuki Hino, Atsuko Nagaoka, Yasushi Iwasaki, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Hirotsugu Azechi, Noriko Kudo, Ryota Hashimoto, Hirooki Yabe, Mari Yoshida, Yuko Saito, Akiyoshi Kakita, Nobuo Fuse, Ryuta Kawashima, Yasuyuki Taki, Hiroaki Tomita

Schizophrenia Bulletin　46　(6)　1619-1628　2020/04/14
Publisher: Oxford University Press (OUP)
DOI： 10.1093/schbul/sbaa049 　

ISSN： 0586-7614

eISSN： 1745-1701

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<title>Abstract</title> Previous studies have indicated associations between several OLIG2 gene single-nucleotide polymorphisms (SNPs) and susceptibility to schizophrenia among Caucasians. Consistent with these findings, postmortem brain and diffusion tensor imaging studies have indicated that the schizophrenia-risk-associated allele (A) in the OLIG2 SNP rs1059004 predicts lower OLIG2 gene expression in the dorsolateral prefrontal cortex (DLPFC) of schizophrenia patients and reduced white matter (WM) integrity of the corona radiata in normal brains among Caucasians. In an effort to replicate the association between this variant and WM integrity among healthy Japanese, we found that the number of A alleles was positively correlated with WM integrity in some fiber tracts, including the right posterior limb of the internal capsule, and with mean blood flow in a widespread area, including the inferior frontal operculum, orbital area, and triangular gyrus. Because the A allele affected WM integrity in opposite directions in Japanese and Caucasians, we investigated a possible association between the OLIG2 gene SNPs and the expression level of OLIG2 transcripts in postmortem DLPFCs. We evaluated rs1059004 and additional SNPs in the 5′ upstream and 3′ downstream regions of rs1059004 to cover the broader region of the OLIG2 gene. The 2 SNPs (rs1059004 and rs9653711) had opposite effects on OLIG2 gene expression in the DLPFC in Japanese and Caucasians. These findings suggest ethnicity-dependent opposite effects of OLIG2 gene SNPs on WM integrity and OLIG2 gene expression in the brain, which may partially explain the failures in replicating associations between genetic variants and psychiatric phenotypes among ethnicities.
周産期におけるメンタルヘルスのスクリーニングと連携のポイント

菊地紗耶, 小林奈津子, 本多奈美, 富田博秋

女性心身医学　24　(3)　244-248　2020/03
Publisher: (一社)日本女性心身医学会
ISSN： 1345-2894
Antidepressant prescriptions for prenatal and postpartum women in Japan: A health administrative database study. International-journal Peer-reviewed

Tomofumi Ishikawa, Taku Obara, Saya Kikuchi, Natsuko Kobayashi, Keiko Miyakoda, Hidekazu Nishigori, Hiroaki Tomita, Manabu Akazawa, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano

Journal of affective disorders　264　295-303　2020/03/01

DOI： 10.1016/j.jad.2020.01.016 　

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BACKGROUND: The prevalence and pattern of perinatal antidepressant prescriptions in Japan are unknown. METHODS: The prevalence of antidepressant prescriptions between 180 days before pregnancy onset and 180 days postpartum was evaluated using a large administrative database. The dates of pregnancy onset and delivery were estimated using developed algorithms. RESULTS: Of 33,941 women, at least one antidepressant was prescribed to 451 (133/10,000 deliveries) between 180 days before pregnancy and 180 days postpartum and to 241 (71/10,000 deliveries) during pregnancy. The prevalence of antidepressant prescriptions decreased during the first and second trimesters and increased in the postpartum period. Of 339 women with antidepressant prescriptions before pregnancy, 151 (44.5%) discontinued it during pregnancy. Selective serotonin-reuptake inhibitors were the most frequently prescribed class of antidepressants in the time period studied (356 women, 105/10,000 deliveries), followed by tricyclic/non-tricyclic antidepressants (101 women, 30/10,000 deliveries). Of the 57 women who had at least one record of paroxetine prescription in the first trimester, 13 (22.8%) were prescribed >25 mg/day. Fifty-seven women (17/10,000 deliveries) were concurrently prescribed two or more classes of antidepressants between 180 days before pregnancy and 180 days postpartum. LIMITATIONS: It may not always have been the case that the prescribed antidepressants were used. Women whose pregnancy ended in an abortion or stillbirth were not included. CONCLUSIONS: Various antidepressants were prescribed to prenatal and postpartum women in Japan. Approximately half of pregnant women discontinued treatment with antidepressants after becoming pregnant. Women of childbearing age should select an appropriate antidepressant considering the risk/benefit profile.
軽傷頭部外傷後の患者の睡眠障害受傷から1年間の後方視的調査

八木橋真央, 中川敦寛, 佐久間篤, 麦倉俊司, 古谷桂子, 工藤大介, 刈部博, 久志本成樹, 富田博秋, 冨永悌二

日本脳神経外傷学会プログラム・抄録集　43回　89-89　2020/02
Publisher: (一社)日本脳神経外傷学会
Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective. International-journal Peer-reviewed

Shinichi Kuriyama, Hirohito Metoki, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Masato Nagai, Hiroko Matsubara, Tomoko Kobayashi, Junichi Sugawara, Gen Tamiya, Atsushi Hozawa, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Takumi Hirata, Ichiro Tsuji, Fuji Nagami, Nobuo Fuse, Tomohiko Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Yoichi Suzuki, Noriko Osumi, Keiko Nakayama, Kiyoshi Ito, Shinichi Egawa, Koichi Chida, Eiichi Kodama, Hideyasu Kiyomoto, Tadashi Ishii, Akito Tsuboi, Hiroaki Tomita, Yasuyuki Taki, Hiroshi Kawame, Kichiya Suzuki, Naoto Ishii, Soichi Ogishima, Satoshi Mizuno, Takako Takai-Igarashi, Naoko Minegishi, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Osamu Tanabe, Seizo Koshiba, Hiroaki Hashizume, Hozumi Motohashi, Teiji Tominaga, Sadayoshi Ito, Kozo Tanno, Kiyomi Sakata, Atsushi Shimizu, Jiro Hitomi, Makoto Sasaki, Kengo Kinoshita, Hiroshi Tanaka, Tadao Kobayashi, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto

International journal of epidemiology　49　(1)　18-19　2020/02/01

DOI： 10.1093/ije/dyz169 　

ISSN： 0300-5771
Study profile of The Tohoku Medical Megabank Community-Based Cohort Study. Peer-reviewed

Atsushi Hozawa, Kozo Tanno, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Akira Narita, Mana Kogure, Kotaro Nochioka, Ryohei Sasaki, Nobuyuki Takanashi, Kotaro Otsuka, Kiyomi Sakata, Shinichi Kuriyama, Masahiro Kikuya, Osamu Tanabe, Junichi Sugawara, Kichiya Suzuki, Yoichi Suzuki, Eiichi N Kodama, Nobuo Fuse, Hideyasu Kiyomoto, Hiroaki Tomita, Akira Uruno, Yohei Hamanaka, Hirohito Metoki, Mami Ishikuro, Taku Obara, Tomoko Kobayashi, Kazuyuki Kitatani, Takako Takai-Igarashi, Soichi Ogishima, Mamoru Satoh, Hideki Ohmomo, Akito Tsuboi, Shinichi Egawa, Tadashi Ishii, Kiyoshi Ito, Sadayoshi Ito, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Masao Nagasaki, Kazuhiko Igarashi, Seizo Koshiba, Ritsuko Shimizu, Gen Tamiya, Keiko Nakayama, Hozumi Motohashi, Jun Yasuda, Atsushi Shimizu, Tsuyoshi Hachiya, Yuh Shiwa, Teiji Tominaga, Hiroshi Tanaka, Kotaro Oyama, Ryoichi Tanaka, Hiroshi Kawame, Akimune Fukushima, Yasushi Ishigaki, Tomoharu Tokutomi, Noriko Osumi, Tadao Kobayashi, Fuji Nagami, Hiroaki Hashizume, Tomohiro Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Ryujin Endo, Satoshi Nishizuka, Ichiro Tsuji, Jiro Hitomi, Motoyuki Nakamura, Kuniaki Ogasawara, Nobuo Yaegashi, Kengo Kinoshita, Shigeo Kure, Akio Sakai, Seiichiro Kobayashi, Kenji Sobue, Makoto Sasaki, Masayuki Yamamoto

Journal of epidemiology　31　(1)　65-76　2020/01/11

DOI： 10.2188/jea.JE20190271 　

ISSN： 0917-5040

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BackgroundWe established a community-based cohort study to assess the long-term impact of the Great East Japan Earthquake on disaster victims and gene-environmental interactions on the incidence of major diseases such as cancer and cardiovascular diseases.MethodsWe asked participants to join our cohort in the health check-up settings and assessment center based settings. Inclusion criteria was aged 20 years or over and living in Miyagi or Iwate Prefecture. We obtained information on lifestyle, effect of disaster, blood, and urine information (Type 1 survey), and some detailed measurements (Type 2 survey), for example, carotid echography, calcaneal ultrasound bone mineral density, and so on. All participants agreed to measure genome information and to distribute their information widely.ResultsAs a result, 87,865 gave their informed consent to join our study. Participation rate at health check-up site was about 70%. The participants with Type 1 survey were more likely to have psychological distress than those of Type 2 survey, and women were more likely to have psychological distress than men. Additionally, coastal residents were more likely to have higher degrees of psychological distress than inland residents regardless of sex.ConclusionThis cohort comprised large sample size and it contains information on disaster, genome information, and metabolome information. This cohort also had several detailed measurements. Using this cohort enabled us to clarify the long-term effect of disaster and also to establish personalized prevention based on genome, metabolome, and other omics information.
Blast-induced traumatic brain injury: Injury mechanisms, pathophysiology, diagnosis, and treatment Peer-reviewed

Nakagawa Atsuhiro, Ohtani Kiyonobu, Yagihashi Mao, Sakuma Atsushi, Tomita Hiroaki, Karibe Hiroshi, Armonda Rocco, Kushimoto Shigeki, Tominaga Teiji

NEUROSURGICAL EMERGENCY　25　(2)　195-202　2020
Publisher: Japan Society of Neurosurgical Emergency
DOI： 10.24723/jsne.25.2_195 　

ISSN： 1342-6214

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A blast wave (BW) is generated by an explosion and is comprised of a lead shock wave followed by a supersonic flow. In addition to civilian traumatic brain injury (TBI) mechanisms, pressure‒induced damage accounts for the occurrence of blast‒induced TBIs (bTBIs). Fracture, hemorrhage, massive and rapid edema progression, and cerebral vasospasm are the characteristic clinical findings of bTBI in the acute phase, and in the chronic period the characteristic clinical findings are cognitive dysfunction and posttraumatic disorder. Since a BW is invisible and impacts the brain within an extremely short period of time (in contrast to direct‒impact and penetrating mechanism injuries), the victim may not immediately realize that s/he has suffered clinically. There have been few animal models that can be examined in the laboratory and validated in terms of shock wave (SW) physics, and this has hampered the understanding of the mechanisms and pathophysiology of bTBIs. At the Institute of Fluid Science, we have successfully formed organized infrastructures and accumulated knowledge concerning SWs and BWs since the 1980s for both engineering issues and medical applications. Here, we describe the pathophysiology and the mechanisms underlying bTBIs and the current research tasks in the field of SW physics. We also describe the diagnoses of blast injury patients and their treatment.
Association Between Autistic Symptoms and Self-Stigma in Patients with Schizophrenia Spectrum Disorders. International-journal

Hiroshi Komatsu, Takashi Ono, Yoshinori Maita, Yusuke Ishida, Tatsuo Kikuchi, Takahiro Maki, Satoshi Hase, Hisakazu Sakurai, Akiko Oba, Osamu Teshirogi, Akira Suzuki, Yasuko Mori, Chikako Shoji, Akira Fujita, Sachiko Takahashi, Takayuki Ebina, Shinya Ozaki, Ryuta Honma, Hiroaki Tomita, Yoshihisa Kakuto

Neuropsychiatric disease and treatment　16　2553-2561　2020

DOI： 10.2147/NDT.S280485 　

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Purpose: Self-stigma negatively influences self-esteem, quality of life, self-efficacy, treatment adherence, and recovery in psychiatric patients. By revealing personality traits that influence self-stigma, we can gain useful knowledge for the management of self-stigma. A previous meta-analysis indicated that patients with schizophrenia have higher scores on the Autism-Spectrum Quotient (AQ) than healthy controls. However, the relationship between autistic symptoms and self-stigma in patients with schizophrenia spectrum disorders remains unclear. Therefore, the present study aimed to reveal the association between autistic symptoms and self-stigma in patients with schizophrenia spectrum disorders. Patients and Methods: We recruited 127 patients with schizophrenia spectrum disorders (schizophrenia, schizoaffective disorder, and delusional disorder). We assessed participants' self-stigma and autistic symptoms using the Internalized Stigma for Mental Illness (ISMI) scale and the Autism-Spectrum Quotient (AQ), respectively. The differences in the scores of ISMI and AQ according to patient characteristics were investigated. Multiple regression analysis controlling for age and gender was performed to determine the relationship between the total scores on the AQ and IMSI scale. Results: Female patients showed a higher level of self-stigma than males. Unmarried patients showed a significantly higher score on the AQ than married patients. Multiple regression analysis adjusted for age and gender indicated that the total score on AQ might be a predictor of the overall rating on ISMI in patients with schizophrenia spectrum disorders. Conclusion: This study is the first to reveal the association between autistic symptoms and self-stigma in patients with schizophrenia spectrum disorders. Our results highlight the importance of considering autistic symptoms in the assessment and management of self-stigma in patients with schizophrenia spectrum disorders.
A single nucleotide polymorphism (−250 A/C) of the GFAP gene is associated with brain structures and cerebral blood flow Peer-reviewed

Yuta Takahashi, Hikaru Takeuchi, Mai Sakai, Zhiqian Yu, Yoshie Kikuchi, Fumiaki Ito, Hiroo Matsuoka, Osamu Tanabe, Jun Yasuda, Yasuyuki Taki, Ryuta Kawashima, Hiroaki Tomita

Psychiatry and Clinical Neurosciences　74　(1)　49-55　2020/01
Publisher: Wiley
DOI： 10.1111/pcn.12932 　

ISSN： 1323-1316

eISSN： 1440-1819
【さまざまな背景のある患者にどうする?-リアルワールドの薬物療法】妊娠授乳期の精神科薬物療法

菊地紗耶, 小林奈津子, 本多奈美, 富田博秋

臨床精神薬理　22　(12)　1205-1212　2019/12
Publisher: (株)星和書店
ISSN： 1343-3474
最新の知見に基づいた周産期における薬物治療のあり方とは何か産後うつ病の薬物療法期待される抗うつ薬とは

菊地紗耶, 小林奈津子, 本多奈美, 富田博秋

総合病院精神医学　31　(Suppl.)　S-104　2019/11
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
軽症頭部外傷の睡眠障害東北大学病院TBIクリニックの受傷から1年間の後方視的調査

佐久間篤, 八木橋真央, 中川敦寛, 麦倉俊司, 内海裕介, 古谷桂子, 工藤大介, 大沢伸一郎, 久志本成樹, 冨永悌二, 富田博秋

総合病院精神医学　31　(Suppl.)　S-195　2019/11
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
東北大学病院精神科リエゾンチームの活動と今後の課題

内海裕介, 鴇田百合子, 佐久間篤, 深谷真理子, 富田博秋

総合病院精神医学　31　(Suppl.)　S-216　2019/11
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
救急医療における身体科-精神科との連携医療圏の特性に応じた最適解を探る〜宮城県の事例を通じて〜救急医療と精神科との連携東北大学病院精神科リエゾンチームの活動

佐久間篤, 鴇田百合子, 内海裕介, 松木佑, 五十嵐江美, 北川佳奈, 渋谷嘉成, 中村元昭, 富田博秋

日本精神科救急学会学術総会プログラム・抄録集　27回　53-53　2019/10
Publisher: (一社)日本精神科救急学会
Minimal amount of tissue‐based pH measurement to improve quality control in neuropsychiatric post‐mortem brain studies Peer-reviewed

Chiaki T. Ono, Zhiqian Yu, Yoshie Kikuchi, Yasuto Kunii, Mizuki Hino, Junya Matsumoto, Atsuko Nagaoka, Junko Ito, Yasushi Iwasaki, Hideo Hagihara, Tsuyoshi Miyakawa, Mari Yoshida, Yuko Saito, Shin‐ichi Niwa, Hirooki Yabe, Akiyoshi Kakita, Hiroaki Tomita

Psychiatry and Clinical Neurosciences　73　(9)　566-573　2019/09
Publisher: Wiley
DOI： 10.1111/pcn.12863 　

ISSN： 1323-1316

eISSN： 1440-1819
Post-disaster mental health;psychosocial support;in the areas affected by the Great East Japan Earthquake;a qualitative study International-journal Peer-reviewed

Seto M, Nemoto H, Kobayashi N, Kikuchi S, Honda N, Kim Y, Kelman I, Tomita H

BMC Psychiatry　19　(1)　261-261　2019/08

DOI： 10.1186/s12888-019-2243-z 　

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BACKGROUND: Few studies exploring the actual practices implemented for long-term mental health and psychosocial support after a natural disaster have been published. This study aimed to reveal (1) the types of activities that were actually provided as mental health and psychosocial support (MHPSS) in the long-term phase after the Great East Japan Earthquake (GEJE) and (2) the problems that must be addressed to provide post-disaster MHPSS activities. METHODS: An open-ended questionnaire was sent to organizations in the Iwate, Miyagi and Fukushima prefectures that were potentially involved in providing MHPSS to communities affected by the GEJE. The organizations were asked to describe their activities and the problems that needed to be addressed to provide these support activities. The collected statements were analysed using content analysis with NVivo11. RESULTS: The support activities conducted to provide MHPSS in the long-term phase after the catastrophe were diverse and classified into 7 major categories, namely, (1) one-on-one support for individuals in need of assistance, (2) support for collective activities, (3) support around living conditions and income, (4) increasing public awareness about mental health, (5) human resource development to improve response capabilities for MHPSS, (6) support for MHPSS providers, and (7) facilitating collaborations among the MHPSS activities provided to affected communities. Problems with human resources and funding were the most frequently mentioned concerns among the organizations participating in the survey. CONCLUSIONS: The establishment of systems to collect and share sufficient and relevant knowledge and to coordinate organizations for long-term post-disaster postventions would be desirable.
A Common CACNA1C Gene Risk Variant has Sex-Dependent Effects on Behavioral Traits and Brain Functional Activity. International-journal Peer-reviewed

Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Yuko Sassa, Ryuta Kawashima

Cerebral cortex (New York, N.Y. : 1991)　29　(8)　3211-3219　2019/07/22

DOI： 10.1093/cercor/bhy189 　

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Genome-wide association studies have suggested that allelic variations in the CACNA1C gene confer susceptibility to schizophrenia and bipolar disorder only in women. Here we investigated the sex-specific effects of the CACNA1C variant rs1024582 on psychiatry-related traits, brain activity during tasks and rest, and brain volume in 1207 normal male and female subjects. After correcting for multiple comparisons, there were significant interaction effects between sex and the minor allele of this polymorphism on the hostile behavior subscale scores of the Coronary-Prone Type Scale mediated by higher scores in female carriers of the minor allele. Imaging analyses revealed significant interaction effects between sex and the minor allele on fractional amplitude of low-frequency fluctuations in the right dorsolateral prefrontal cortex and on brain activity during the 2-back task in areas of the right posterior cingulate cortex, right thalamus, and right hippocampus, which were all mediated by reduced activity in female carriers of the minor allele. Our results demonstrated that the rs1024582 risk variant of CACNA1C is associated with reduced activity in the frontolimbic regions at rest and during a working memory task as well as with greater hostility in females in the healthy population.
Genome-wide association meta-analysis and Mendelian randomization analysis confirm the influence of ALDH2 on sleep durationin the Japanese population. International-journal Peer-reviewed

Takeshi Nishiyama, Masahiro Nakatochi, Atsushi Goto, Motoki Iwasaki, Tsuyoshi Hachiya, Yoichi Sutoh, Atsushi Shimizu, Chaochen Wang, Hideo Tanaka, Miki Watanabe, Akihiro Hosono, Yuya Tamai, Tamaki Yamada, Taiki Yamaji, Norie Sawada, Kentaro Fukumoto, Kotaro Otsuka, Kozo Tanno, Hiroaki Tomita, Kaname Kojima, Masao Nagasaki, Atsushi Hozawa, Asahi Hishida, Tae Sasakabe, Yuichiro Nishida, Megumi Hara, Hidemi Ito, Isao Oze, Yohko Nakamura, Haruo Mikami, Rie Ibusuki, Toshiro Takezaki, Teruhide Koyama, Nagato Kuriyama, Kaori Endoh, Kiyonori Kuriki, Tanvir C Turin, Takashima Naoyuki, Sakurako Katsuura-Kamano, Hirokazu Uemura, Rieko Okada, Sayo Kawai, Mariko Naito, Yukihide Momozawa, Michiaki Kubo, Makoto Sasaki, Masayuki Yamamoto, Shoichiro Tsugane, Kenji Wakai, Sadao Suzuki

Sleep　42　(6)　1-11　2019/06/11

DOI： 10.1093/sleep/zsz046 　

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Usual sleep duration has substantial heritability and is associated with various physical and psychiatric conditions as well as mortality. However, for its genetic locus, only PAX8 and VRK2 have been replicated in previous genome-wide association studies (GWAS). We conducted a GWAS meta-analysis of self-reported usual sleep duration using three population-based cohorts totaling 31 230 Japanese individuals. A genome-wide significant locus was identified at 12q24 (p-value < 5.0 × 10-8). Subsequently, a functional variant in the ALDH2 locus, rs671, was replicated in an independent sample of 5140 Japanese individuals (p-value = 0.004). The association signal, however, disappeared after adjusting for alcohol consumption, indicating the possibility that the rs671 genotype modifies sleep duration via alcohol consumption. This hypothesis explained a modest genetic correlation observed between sleep duration and alcohol consumption (rG = 0.23). A Mendelian randomization analysis using rs671 and other variants as instrumental variables confirmed this by showing a causal effect of alcohol consumption, but not of coffee consumption on sleep duration. Another genome-wide significant locus was identified at 5q33 after adjusting for drinking frequency. However, this locus was not replicated, nor was the PAX8 and VRK2. Our study has confirmed that a functional ALDH2 variant, rs671, most strongly influences on usual sleep duration possibly via alcohol consumption in the Japanese population, and presumably in East Asian populations. This highlights the importance of considering the involvement of alcohol consumption in future GWAS of usual sleep duration, even in non-East Asian populations, where rs671 is monomorphic.
周産期における統合失調症患者の薬物療法と再発に関する後方視的研究

菊地紗耶, 小林奈津子, 本多奈美, 富田博秋

精神神経学雑誌　(2019特別号)　S443-S443　2019/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
東日本大震災における周産期の女性と地域母子保健ヘルスケア従事者の経験に関する質的研究

小林奈津子, 菊地紗耶, 本多奈美, 富田博秋

精神神経学雑誌　(2019特別号)　S650-S650　2019/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
さまざまな精神神経疾患の妊娠・出産・授乳への対応気分障害合併妊産婦に対する妊娠・出産・授乳への対応

菊地紗耶, 小林奈津子, 本多奈美, 富田博秋

精神神経学雑誌　(2019特別号)　S709-S709　2019/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
ゲノムワイド遺伝子多型データを用いた機械学習によるうつ状態脆弱性の予測

高橋雄太, 植木優夫, 田宮元, 荻島創一, 長神風二, 福本健太郎, 大塚耕太郎, 山本雅之, 富田博秋

精神神経学雑誌　(2019特別号)　S609-S609　2019/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
メタボロームデータを用いた非線形変数選択機械学習によるうつ状態の予測

高橋雄太, 植木優夫, 山田誠, 田宮元, 元池育子, 三枝大輔, 櫻井美由紀, 長神風二, 小柴生造, 木下賢吾, 山本雅之, 富田博秋

精神神経学雑誌　(2019特別号)　S609-S609　2019/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
東日本大震災被災地における中長期的な心理社会的支援の実態と課題

瀬戸萌, 富田博秋, 根本晴美, 小林奈津子, 金吉晴

精神神経学雑誌　(2019特別号)　S631-S631　2019/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
東日本大震災が沿岸地域の就労と精神的健康に及ぼした影響

片柳光昭, 富田博秋, 瀬戸萌, 根本晴美, 奥山純子, 鈴木智美, 菅原由美, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 小高晃, 辻一郎, 寳澤篤

精神神経学雑誌　(2019特別号)　S753-S753　2019/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
頭部外傷受傷者に対する東北大学病院精神科リエゾンチームの取り組み

佐久間篤, 八木橋真央, 中川敦寛, 麦倉俊司, 古谷桂子, 工藤大介, 大沢伸一郎, 久志本成樹, 冨永悌二, 富田博秋

精神神経学雑誌　(2019特別号)　S764-S764　2019/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
災害後の精神的健康状態と歩行習慣の関連

内海裕介, 富田博秋, 根本晴美, 奥山純子

精神神経学雑誌　(2019特別号)　S438-S438　2019/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
OLIG2遺伝子多型(rs1059004)と自己スキーマ及び抑うつ症状との関連 Peer-reviewed

小松浩, 竹内光, 菊地淑恵, 小野千晶, 兪志前, 飯塚邦夫, 角藤芳久, 舩越俊一, 大野高志, 川島隆太, 瀧龍之, 富田博秋

精神神経学雑誌　(2019特別号)　S452-S452　2019/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
Prefabricated Temporary Housing and Eczema or Respiratory Symptoms in Schoolchildren after the Great East Japan Earthquake: The ToMMo Child Health Study. International-journal Peer-reviewed

Kuniyoshi Y, Kikuya M, Miyashita M, Yamanaka C, Ishikuro M, Obara T, Metoki H, Nakaya N, Nagami F, Tomita H, Hozawa A, Tsuji I, Kure S, Yaegashi N, Kuriyama S

Disaster medicine and public health preparedness　13　(5-6)　1-7　2019/06

DOI： 10.1017/dmp.2019.8 　

ISSN： 1935-7893

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OBJECTIVE: We aimed to investigate the association between types of housing and allergic symptoms at 3-4 years following the Great East Japan Earthquake. METHODS: Our study was based on the ToMMo Child Health Study conducted in 2014 and 2015, a cross-sectional survey of public school children in Miyagi Prefecture, Japan. Of the 46 648 invited schoolchildren in the 2nd to 8th grades, 9884 were included. Presence of eczema, wheezing, and mental health symptoms was defined with questionnaires. To calculate odds ratios (ORs) and 95% CIs for the associations between types of housing and eczema or respiratory symptoms, we fitted generalized linear mixed models, included a random effect for municipality of residence, and adjusted for sex, school grade, survey year, and mental health symptoms. RESULTS: Prefabricated temporary housing was significantly associated with eczema symptoms (OR, 1.46; 95% CI, 1.06-2.02). Even after adjusting for the presence of mental health symptoms, our analysis produced similar results (OR, 1.42; 95% CI, 1.03-1.96). Conversely, it was not significantly associated with respiratory symptoms (OR, 0.97; 95% CI, 0.61-1.54). CONCLUSIONS: Children living in prefabricated temporary housing had a higher prevalence of eczema symptoms; however, prevalence of respiratory symptoms was not significantly higher.
脳神経外傷の画像診断びまん性軸索損傷の診断に関する来院時CTの意義

中川敦寛, 麦倉俊司, 今井啓道, 八木橋真央, 佐久間篤, 大沢伸一郎, 工藤大介, 刈部博, 近田祐介, 冨田博秋, 久志本成樹, 冨永悌二

日本脳神経外傷学会プログラム・抄録集　42回　61-61　2019/02
Publisher: (一社)日本脳神経外傷学会
スポーツ神経外傷の課題と対応学校における脳振盪教育現場の実情と課題

中川敦寛, 刈部博, 荻野雅宏, 八木橋真央, 中山晴雄, 望月浩一郎, 佐久間篤, 大沢伸一郎, 冨田博秋, 久志本成樹, 冨永悌二

日本脳神経外傷学会プログラム・抄録集　42回　66-66　2019/02
Publisher: (一社)日本脳神経外傷学会
頭部外傷後の患者への精神科介入判断に関する考察質と量的データの関連から

八木橋真央, 佐久間篤, 中川敦寛, 麦倉俊司, 古谷桂子, 工藤大介, 大沢伸一郎, 久志本成樹, 冨永悌二, 富田博秋

日本脳神経外傷学会プログラム・抄録集　42回　115-115　2019/02
Publisher: (一社)日本脳神経外傷学会
Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare. International-journal Peer-reviewed

Jun Yasuda, Kengo Kinoshita, Fumiki Katsuoka, Inaho Danjoh, Mika Sakurai-Yageta, Ikuko N Motoike, Yoko Kuroki, Sakae Saito, Kaname Kojima, Matsuyuki Shirota, Daisuke Saigusa, Akihito Otsuki, Junko Kawashima, Yumi Yamaguchi-Kabata, Shu Tadaka, Yuichi Aoki, Takahiro Mimori, Kazuki Kumada, Jin Inoue, Satoshi Makino, Miho Kuriki, Nobuo Fuse, Seizo Koshiba, Osamu Tanabe, Masao Nagasaki, Gen Tamiya, Ritsuko Shimizu, Takako Takai-Igarashi, Soichi Ogishima, Atsushi Hozawa, Shinichi Kuriyama, Junichi Sugawara, Akito Tsuboi, Hideyasu Kiyomoto, Tadashi Ishii, Hiroaki Tomita, Naoko Minegishi, Yoichi Suzuki, Kichiya Suzuki, Hiroshi Kawame, Hiroshi Tanaka, Yasuyuki Taki, Nobuo Yaegashi, Shigeo Kure, Fuji Nagami, Kenjiro Kosaki, Yoichi Sutoh, Tsuyoshi Hachiya, Atsushi Shimizu, Makoto Sasaki, Masayuki Yamamoto

Journal of biochemistry　165　(2)　139-158　2019/02/01

DOI： 10.1093/jb/mvy096 　

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Personalized healthcare (PHC) based on an individual's genetic make-up is one of the most advanced, yet feasible, forms of medical care. The Tohoku Medical Megabank (TMM) Project aims to combine population genomics, medical genetics and prospective cohort studies to develop a critical infrastructure for the establishment of PHC. To date, a TMM CommCohort (adult general population) and a TMM BirThree Cohort (birth+three-generation families) have conducted recruitments and baseline surveys. Genome analyses as part of the TMM Project will aid in the development of a high-fidelity whole-genome Japanese reference panel, in designing custom single-nucleotide polymorphism (SNP) arrays specific to Japanese, and in estimation of the biological significance of genetic variations through linked investigations of the cohorts. Whole-genome sequencing from >3,500 unrelated Japanese and establishment of a Japanese reference genome sequence from long-read data have been done. We next aim to obtain genotype data for all TMM cohort participants (>150,000) using our custom SNP arrays. These data will help identify disease-associated genomic signatures in the Japanese population, while genomic data from TMM BirThree Cohort participants will be used to improve the reference genome panel. Follow-up of the cohort participants will allow us to test the genetic markers and, consequently, contribute to the realization of PHC.
rs1360780 of the FKBP5 gene modulates the association between maternal acceptance and regional gray matter volume in the thalamus in children and adolescents. Peer-reviewed

Matsudaira I, Oba K, Takeuchi H, Sekiguchi A, Tomita H, Taki Y, Kawashima R

PloS one　14　(8)　e0221768-e0221768　2019
Publisher: Public Library of Science (PLoS)
DOI： 10.1371/journal.pone.0221768 　

eISSN： 1932-6203
神経炎症に対するニューロサイエンスと精神薬理学の協働心的外傷後ストレス反応・抑うつに関わるミクログリアのサイトカイン産生と関連薬剤 Peer-reviewed

富田博秋, 兪志前, 小野千晶

日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集　28回・48回　136-136　2018/11
Publisher: 日本臨床精神神経薬理学会・日本神経精神薬理学会
大学病院総合診療科初診患者のうつ状態を評価するためのハミルトンうつ病評価尺度の有用性

阿部倫明, 野崎裕之, 中川高, 八木橋真央, 石沢興太, 奥田拓史, 赤石哲也, 田中淳一, 大澤稔, 沼田健裕, 菊地章子, 高山真, 奈良正之, 小野寺浩, 富田博秋, 石井正

日本病院総合診療医学会雑誌　14　(6)　556-563　2018/11
Publisher: (一社)日本病院総合診療医学会
ISSN： 2185-8136
精神科病院の災害対策～東日本大震災と熊本地震の教訓から～ Peer-reviewed

富田博秋, 山口喜久雄, 富田正徳, 矢田部裕介, 犬飼邦明, 相澤明憲, 伴亨, 高階憲之, 岩舘敏晴, 菅野庸, 渡部康, 千葉潜, 松田ひろし

日本精神科病院協会雑誌　37　(11)　10-16　2018/11
自然災害に被災した高校生におけるレジリエンス向上にむけた生活習慣の検討

奥山純子, 吉田弘和, 佐藤和繁, 富田博秋

日本児童青年精神医学会総会抄録集　59回　O9-1　2018/10
Publisher: (一社)日本児童青年精神医学会
頭部外傷診療における救急医と脳神経外科医の役割頭部外傷クリニック脳振盪に対する対応の変化を踏まえた救急医と脳神経外科医の役割分担

中川敦寛, 富田博秋, 佐久間篤, 八木橋真央, 麦倉俊司, 大沢伸一郎, 刈部博, ジェフリー・マンレー, 久志本成樹, 冨永悌二

日本救急医学会雑誌　29　(10)　330-330　2018/10
Publisher: (一社)日本救急医学会
ISSN： 0915-924X

eISSN： 1883-3772
知っておきたい避難所・仮設住宅などでの生活 Peer-reviewed

丸谷浩明, 伊藤潔, 富田博秋, 児玉栄一

共済と保険　60　(10)　4-9　2018/10
Strategic Methods for Recruiting Grandparents: The Tohoku Medical Megabank Birth and Three-Generation Cohort Study. Peer-reviewed

Mami Ishikuro, Taku Obara, Tamae Osanai, Chizuru Yamanaka, Yuki Sato, Satoshi Mizuno, Masako Miyashita, Masahiro Kikuya, Kasumi Sakurai, Atsushi Hozawa, Hiroaki Tomita, Yasuyuki Taki, Fuji Nagami, Hirohito Metoki, Shinichi Kuriyama

The Tohoku journal of experimental medicine　246　(2)　97-105　2018/10

DOI： 10.1620/tjem.246.97 　

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Involvement of family members, especially grandparents, in genome epidemiological research is important to investigate both genetic and environmental factors of common diseases. The aim of the present study was to establish strategies to obtain enough number of family recruitment, especially focusing on grandparents, for the Tohoku Medical Megabank Birth and Three-Generation Cohort Study. Our main strategies are summarized below. 1) We standardized informed consent process with reference materials to help people understand the consent form, 2) we created an invitation letter to contact family members, and 3) we recruited family members in several settings. To obtain informed consent, we were careful of explaining clearly the complex reasons as well as drawing people's attention. By the end of March 2017, the number of invitation letters distributed to family members through the pregnant women was 23,806, including 18,702 grandparents. Among the grandparents who received invitation letters, 2,935 (15.7%) responded to us. Furthermore, some grandparents were asked to provide informed consent with other family members by staff at maternal clinics or Community Support Centers, and others directly booked Community Support Centers without responding to the invitation letter. Grandparents joined the study anytime during mother's maternal check-ups or delivery. Overall, 8,054 grandparents participated in our birth cohort study. The setting in which most grandparents were recruited was our own facilities. Importantly, both paternal and maternal grandparents more frequently participated in the study if the father also participated. In conclusion, we are able to recruit not only pregnant women but also fathers and grandparents.
Severity of eczema and mental health problems in Japanese schoolchildren: The ToMMo Child Health Study. International-journal Peer-reviewed

Yasutaka Kuniyoshi, Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, Taku Obara, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Atsushi Hozawa, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama

Allergology international : official journal of the Japanese Society of Allergology　67　(4)　481-486　2018/10

DOI： 10.1016/j.alit.2018.02.009 　

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BACKGROUND: The association between eczema and mental health problems in schoolchildren has been underexplored. We aimed to investigate this association with the validated questionnaires. METHODS: Of 46,648 invited children, we analyzed 9954 (21.3%) in the 2nd to the 8th grades from the ToMMo Child Health Study conducted in 2014 and 2015, a cross-sectional survey in Miyagi Prefecture, Japan. We defined eczema status as "normal," "mild/moderate," or "severe," based on the presence of persistent flexural eczema and sleep disturbance, according to the International Study of Asthma and Allergies in Childhood (ISAAC) Eczema Symptom Questionnaire. Clinical ranges of Strengths and Difficulties Questionnaire (SDQ) total difficulties scores and four SDQ subcategories of emotional symptoms, conduct problems, hyperactivity/inattention, and peer problems were defined as scores ≥16, ≥5, ≥5, ≥7, and ≥5, respectively. RESULTS: The mean SDQ total difficulties score significantly increased as eczema status worsened (all P ≤ 0.004 for trend). The OR of scores in the clinical range for SDQ total difficulties were 1.51 (95% CI, 1.31-1.74) for mild/moderate eczema and 2.63 (95% CI, 1.91-3.63) for severe eczema (P < 0.001 for trend), adjusted for sex, school grade, current wheeze, and disaster-related factors, using normal eczema as a reference. The association between severity of eczema and four SDQ subcategories showed a similar trend (all P ≤ 0.017 for trend). CONCLUSIONS: We found a significant association between severity of eczema and mental health problems. The presence of eczema was associated with four SDQ subcategories.
災害後の心的外傷後ストレス反応と身体活動量との関連

内海裕介, 富田博秋

スポーツ精神医学　15　A18-A18　2018/08
Publisher: 日本スポーツ精神医学会
ISSN： 1349-4929
Longitudinal Characteristics of Resilience among Adolescents: A high school student cohort study to assess the psychological impact of the Great East Japan Earthquake. International-journal Peer-reviewed

Hiroaki Tomita

Psychiatry and Clinical Neurosciences　72　(11)　821-835　2018/07

DOI： 10.1111/pcn.12772 　

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AIM: Resilience, the ability to cope with disasters and significant life adversity, is an important factor to consider when studying the mental health of populations affected by a disaster. Although high school students in a community affected by a disaster should have specific characteristics of resilience, little has been reported on the issue. This study was designed to provide initial data regarding characteristics of the resilience of high school students affected by a catastrophe. METHODS: A total of 760 high school students in Natori City, which was devastated by the Great East Japan Earthquake in 2011, were profiled, and a 3-year longitudinal study was conducted with 254 students who had entered the school in 2012. Resilience was evaluated with the 10-item Connor-Davidson Resilience Scale. The Quick Inventory of Depressive Symptomatology-Japanese version, the Zung Self-Rating Anxiety Scale, and the Impact of Event Scale-Revised were also administered to assess the students' mental health. RESULTS: Among the students who entered the high school in 2012, 28.6% showed high resilience, and the proportion increased to 42.9% in 2013 and 46.6% in 2014. The Quick Inventory of Depressive Symptomatology-Japanese version and Impact of Event Scale-Revised scores decreased significantly over the 3-year study period, but there were no significant differences in the Zung Self-Rating Anxiety Scale scores over time. CONCLUSION: This initial study profiling the characteristics of resilience among adolescents suggests that resilience is a highly changeable component of mental health among people who have faced adversity. Resilience can be a useful indicator of recovery from adversity and a target of interventions for improving mental health conditions.
Effect of tsunami drill experience on evacuation behavior after the onset of the Great East Japan Earthquake Peer-reviewed

Naoki Nakaya, Harumi Nemoto, Carine Yi, Ayako Sato, Kotomi Shingu, Tomoka Shoji, Shosuke Sato, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Yumi Sugawara, Zhiqian Yu, Nicole Gunawansa, Shinichi Kuriyama, Osamu Murao, Takeshi Sato, Fumihiko Imamura, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

International Journal of Disaster Risk Reduction　28　206-213　2018/06/01
Publisher: Elsevier Ltd
DOI： 10.1016/j.ijdrr.2018.02.037 　

ISSN： 2212-4209
Polymorphisms in the microglial marker molecule CX3CR1 affect the blood volume of the human brain Peer-reviewed

Mai Sakai, Hikaru Takeuchi, Zhiqian Yu, Yoshie Kikuchi, Chiaki Ono, Yuta Takahashi, Fumiaki Ito, Hiroo Matsuoka, Osamu Tanabe, Jun Yasuda, Yasuyuki Taki, Ryuta Kawashima, Hiroaki Tomita

Psychiatry and Clinical Neurosciences　72　(6)　409-422　2018/06/01
Publisher: Blackwell Publishing
DOI： 10.1111/pcn.12649 　

ISSN： 1440-1819 1323-1316

eISSN： 1440-1819
Cumulative incidence of suicidal ideation and associated factors among adults living in temporary housing during the three years after the Great East Japan Earthquake Peer-reviewed

Qingyi Xu, Maiko Fukasawa, Norito Kawakami, Toshiaki Baba, Kiyomi Sakata, Ruriko Suzuki, Hiroaki Tomita, Harumi Nemoto, Seiji Yasumura, Hirooki Yabe, Naoko Horikoshi, Maki Umeda, Yuriko Suzuki, Haruki Shimoda, Hisateru Tachimori, Tadashi Takeshima, Evelyn J. Bromet

Journal of Affective Disorders　232　1-8　2018/05/01
Publisher: Elsevier B.V.
DOI： 10.1016/j.jad.2018.01.021 　

ISSN： 1573-2517 0165-0327
Association between mild physical injury and psychological distress: Shichigahama Health Promotion Project Peer-reviewed

NARITA Akira, NAKAYA Naoki, NAKAMURA Tomohiro, TSUCHIYA Naho, KOGURE Mana, TSUJI Ichiro, HOZAWA Atsushi, TOMITA Hiroaki

Nihon Koshu Eisei Zasshi(JAPANESE JOURNAL OF PUBLIC HEALTH)　65　(4)　157-163　2018
Publisher: Japanese Society of Public Health
DOI： 10.11236/jph.65.4_157 　

ISSN： 0546-1766

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Objective Although a number of previous studies have investigated the association between natural disaster-related physical injury and mental health, very few have focused on mild physical injury. The aim of this study was to evaluate the association between natural disaster-related mild physical injury and psychological distress in a cross-sectional study.Method This study is a part of the Shichigahama Health Promotion Project, which was conducted in cooperation with the Tohoku University and Shichigahama Town, Miyagi Prefecture, after the Great East Japan Earthquake (GEJE). We conducted the research about one year after the GEJE, and performed logistic regression analyses using 3,844 participants (1,821 males/2,023 females) aged 20 years or older, who answered all the questions on physical injuries and the Kessler 6 scale (K6), after adjusting for gender, age, social factors, and lifestyles. Psychological distress was defined as a K6 score ≥ 13 out of 24 points. We also investigated the effect of other disaster situations on the association between mild physical injury and psychological distress by stratifying the dataset by bereavement, witnessing someone's death, and house damage.Results The participants with physical injury were at a significantly higher risk of psychological distress, with an adjusted odds ratio (aOR) of 2.05 and 95% confidence interval (CI) of 1.26-3.34, than those uninjured. Additionally, the participants with mild physical injury were at a significantly higher risk of psychological distress (aOR=2.18, 95% CI=1.32-3.59). In the subgroup of participants with small-scale house damage, mild physical injury was significantly associated with psychological distress with an aOR of 4.01 and 95% CI of 2.03-7.93, whereas not in the subgroup of those with large-scale house damage, and a significant interaction was detected between mild physical injury and house damage.Conclusion We investigated the association between natural disaster-related physical injury and psychological distress in a cohort of approximately 4,000 residents in an area devastated by the GEJE. In this study, natural disaster-related physical injury was positively associated with psychological distress. The finding indicates that even mild physical injury can be an indicator of high risk for psychological distress.
災害精神医学から見る復興と障害～障害に関わる医療福祉保健従事者に必要な知識とスキル～ Peer-reviewed

佐久間篤, 富田博秋

総合リハビリテーション　45　(12)　1211-1218　2017/12

DOI： 10.11477/mf.1552201168 　
東北大学病院総合診療外来における簡易心理検査の有用性と関連要因の検討 Peer-reviewed

野崎裕之, 中川高, 阿部倫明, 八木橋真央, 甲賀ひとみ, 吉村直仁, 有田龍太郎, 齊藤奈津美, 田中淳一, 沼田健裕, 菅野武, 鈴木聡子, 大澤稔, 菊池章子, 黒田仁, 高山真, 奈良正之, 富田博秋, 石井正

総合病院精神医学　29　(Suppl.)　S-203　2017/11
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
Primary blast-induced traumatic brain injury: lessons from lithotripsy Peer-reviewed

A. Nakagawa, K. Ohtani, R. Armonda, H. Tomita, A. Sakuma, S. Mugikura, K. Takayama, S. Kushimoto, T. Tominaga

SHOCK WAVES　27　(6)　863-878　2017/11

DOI： 10.1007/s00193-017-0753-5 　

ISSN： 0938-1287

eISSN： 1432-2153
自然災害に被災した高校生におけるレジリエンスとこころの健康指標との相関の検討

奥山純子, 舩越俊一, 佐藤和繁, 富田博秋

日本児童青年精神医学会総会抄録集　58回　116-116　2017/10
Publisher: (一社)日本児童青年精神医学会
Psychological distress and the incident risk of functional disability in elderly survivors after the Great East Japan Earthquake Peer-reviewed

Fumiya Tanji, Yumi Sugawara, Yasutake Tomata, Takashi Watanabe, Kemmyo Sugiyama, Yu Kaiho, Hiroaki Tomita, Ichiro Tsuji

JOURNAL OF AFFECTIVE DISORDERS　221　145-150　2017/10

DOI： 10.1016/j.jad.2017.06.030 　

ISSN： 0165-0327

eISSN： 1573-2517
Mental health and school-based intervention among adolescent exposed to the 2011 Great East Japan Earthquake and tsunami Peer-reviewed

Junko Okuyama, Shunichi Funakoshi, Hiroaki Tomita, Takuhiro Yamaguchi, Hiroo Matsuoka

INTERNATIONAL JOURNAL OF DISASTER RISK REDUCTION　24　183-188　2017/09

DOI： 10.1016/j.ijdrr.2017.06.012 　

ISSN： 2212-4209
School-Based Interventions Aimed at the Prevention and Treatment of Adolescents Affected by the 2011 Great East Japan Earthquake: A Three-Year Longitudinal Study Peer-reviewed

Junko Okuyama, Shunichi Funakoshi, Hiroaki Tomita, Takuhiro Yamaguchi, Hiroo Matsuoka

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　242　(3)　203-213　2017/07

DOI： 10.1620/tjem.242.203 　

ISSN： 0040-8727

eISSN： 1349-3329
The VEGF gene polymorphism impacts brain volume and arterial blood volume. International-journal Peer-reviewed

Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Human brain mapping　38　(7)　3516-3526　2017/07

DOI： 10.1002/hbm.23606 　

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Vascular endothelial growth factor (VEGF) plays a critical role in the angiogenesis and proliferation of various types of cells such as neurons, astroglia, and endothelial cells in the brain. A common polymorphism in the VEGF gene (-2578 C/A) is associated with circulating VEGF levels, cancers and Alzheimer's disease. Nonetheless, the effects of this polymorphism on normal human brain volume, arterial blood volume, and blood supply remain unclear. In this study, the effects of this polymorphism on the total gray matter volume (TGMV) and total white matter volume (TWMV) using T1-weighted structural images and the total arterial blood volume (TABV) and mean cerebral blood flow (mCBF) during rest using arterial spin labeling (ASL) in 765 young adult humans were investigated. Voxel-by-voxel whole-brain analyses of these measures were also performed. Multiple regression analyses with age and sex as covariates revealed that the VEGF genotype (number of C alleles) was significantly and positively correlated with TGMV, TWMV, and TABV as well as with regional gray and white matter volumes in widespread areas and regional arterial blood volume in some areas with high arterial blood volume. However, these regional associations were not seen when the corresponding global signal was included as a covariate in the multiple regression analyses, indicating that we failed to obtain evidence of region-specific associations between these brain measures and the genotype. The results suggest that the VEGF-2578C allele, is associated with changes in the vascular system that lead to increased blood volume and larger brain volume. Hum Brain Mapp 38:3516-3526, 2017. © 2017 Wiley Periodicals, Inc.
グリア線維酸性蛋白質遺伝子多型の脳構造への影響の検討精神疾患感受性メカニズムの理解に向けて

高橋雄太, 伊藤文晃, 竹内光, 坂井舞, 兪志前, 松岡洋夫, 瀧靖之, 川島隆太, 富田博秋

精神神経学雑誌　(2017特別号)　S622-S622　2017/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
Psychological Distress and the Risk of Withdrawing From Hypertension Treatment After an Earthquake Disaster Peer-reviewed

Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS　11　(2)　179-182　2017/04

DOI： 10.1017/dmp.2016.102 　

ISSN： 1935-7893

eISSN： 1938-744X
発達障害・過成長児に対するソトス症候群鑑別スクリーニング検査法の開発

富田博秋, 小野千晶

先進医薬研究振興財団研究成果報告集　2016年度　26-27　2017/03
Publisher: (公財)先進医薬研究振興財団
ISSN： 2189-1303
災害精神医学領域におけるアウトリーチ支援 Peer-reviewed

富田博秋, 佐久間篤

臨床精神医学　46　(2)　199-204　2017/02
東日本大震災から5年こころの復興、こころの防災の現在と未来 Peer-reviewed

富田博秋

トラウマティック・ストレス　15　(1)　3-16　2017
Impact of social capital on psychological distress and interaction with house destruction and displacement after the Great East Japan Earthquake of 2011 Peer-reviewed

Naho Tsuchiya, Naoki Nakaya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Jun Aida, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

PSYCHIATRY AND CLINICAL NEUROSCIENCES　71　(1)　52-60　2017/01

DOI： 10.1111/pcn.12467 　

ISSN： 1323-1316

eISSN： 1440-1819
Microglial production of TNF-alpha is a key element of sustained fear memory Peer-reviewed

Zhiqian Yu, Tiotaka Fukushima, Chiaki Ono, Mai Sakai, Yoshiyuki Kasahara, Yoshie Kikuchi, Nicole Gunawansa, Yuta Takahashi, Hiroo Matsuoka, Satoshi Kida, Hiroaki Tomita

BRAIN BEHAVIOR AND IMMUNITY　59　313-321　2017/01

DOI： 10.1016/j.bbi.2016.08.011 　

ISSN： 0889-1591

eISSN： 1090-2139
災害時精神医療の現状と展望 Peer-reviewed

富田博秋

Depression Strategy　6　(4)　1-4　2016/12
爆風による外傷性損傷：テロ対応の観点から Peer-reviewed

中川敦寛, 大谷清伸, 富田博秋, 久志本成樹, Rocco Armonda, 冨永悌二

安全工学　55　(6)　441-446　2016/12

DOI： 10.18943/safety.55.6_441 　
μ-オピオイド受容体ノックアウトマウスのアルコール摂取量に及ぼす青年期ストレスの影響の性差(Sex Differences in the Effects of Adolescent Stress on Alcohol Consumption in μ-Opioid Receptor Knockout Mice)

森屋由紀, 笠原好之, Hall F. Scott, Uhl George R., 曽良一郎, 富田博秋

日本神経精神薬理学雑誌　36　(5-6)　123-124　2016/11
Publisher: (一社)日本神経精神薬理学会
ISSN： 1340-2544
Disturbed social recognition and impaired risk judgement in older residents with mild cognitive impairment after the Great East Japan Earthquake of 2011: the Tome Project Peer-reviewed

Kyoko Akanuma, Kei Nakamura, Kenichi Meguro, Masanori Chiba, Sergio Ramon Gutierrez Ubeda, Keiichi Kumai, Yuka Kato, Jiro Oonuma, Mari Kasai, Masahiro Nakatsuka, Takashi Seki, Hiroaki Tomita

Psychogeriatrics　16　(6)　349-354　2016/11

DOI： 10.1111/psyg.12175 　

ISSN： 1346-3500

eISSN： 1479-8301
東日本大震災に被災した高校生の精神的影響について

舩越俊一, 奥山純子, 佐藤和繁, 富田博秋

日本児童青年精神医学会総会抄録集　57回　160-160　2016/10
Publisher: (一社)日本児童青年精神医学会
The Tohoku Medical Megabank Project: Design and Mission Peer-reviewed

Shinichi Kuriyama, Nobuo Yaegashi, Fuji Nagami, Tomohiko Arai, Yoshio Kawaguchi, Noriko Osumi, Masaki Sakaida, Yoichi Suzuki, Keiko Nakayama, Hiroaki Hashizume, Gen Tamiya, Hiroshi Kawame, Kichiya Suzuki, Atsushi Hozawa, Naoki Nakaya, Masahiro Kikuya, Hirohito Metoki, Ichiro Tsuji, Nobuo Fuse, Hideyasu Kiyomoto, Junichi Sugawara, Akito Tsuboi, Shinichi Egawa, Kiyoshi Ito, Koichi Chida, Tadashi Ishii, Hiroaki Tomita, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Seizo Koshiba, Kengo Kinoshita, Soichi Ogishima, Takako Takai-Igarashi, Teiji Tominaga, Osamu Tanabe, Noriaki Ohuchi, Toru Shimosegawa, Shigeo Kure, Hiroshi Tanaka, Sadayoshi Ito, Jiro Hitomi, Kozo Tanno, Motoyuki Nakamura, Kuniaki Ogasawara, Seiichiro Kobayashi, Kiyomi Sakata, Mamoru Satoh, Atsushi Shimizu, Makoto Sasaki, Ryujin Endo, Kenji Sobue, Masayuki Yamamoto

JOURNAL OF EPIDEMIOLOGY　26　(9)　493-511　2016/09

DOI： 10.2188/jea.JE20150268 　

ISSN： 0917-5040
震災関連動画の視聴前後における心理的変化の検討

加藤大延, 小野千晶, 内田知宏, 富田博秋

日本社会精神医学会雑誌　25　(3)　270-270　2016/08
Publisher: (一社)日本社会精神医学会
ISSN： 0919-1372
震災後メンタルヘルスの現状について教えてください Peer-reviewed

富田博秋

DEPRESSION JOURNAL　4　(2)　22-23　2016/08
Partners' Ongoing Treatment for Chronic Disease and the Risk of Psychological Distress after the Great East Japan Earthquake Peer-reviewed

Naoki Nakaya, Akira Narita, Naho Tsuchiya, Tomohiro Nakamura, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　239　(4)　307-314　2016/08

DOI： 10.1620/tjem.239.307 　

ISSN： 0040-8727

eISSN： 1349-3329
リチウム投与下でのマウスミクログリアと末梢単球の遺伝子発現プロフィール変化の検討

高橋雄太, 兪志前, 坂井舞, 富田博秋

日本神経精神薬理学会年会プログラム・抄録集　46回　218-218　2016/07
Publisher: (一社)日本神経精神薬理学会
胎児期オキシトシン投与時の胎児脳および成体脳における遺伝子発現変化の解析 Peer-reviewed

鈴木祥恵, 尾之内勇治, 笠原好之, 小野千晶, 菊地淑恵, 兪志前, 富田博秋

日本神経精神薬理学会年会プログラム・抄録集　46回　224-224　2016/07
Publisher: (一社)日本神経精神薬理学会
胎児期のオキシトシン曝露による成育後の不安行動、社会行動への影響 Peer-reviewed

尾之内勇治, 鈴木祥恵, 笠原好之, 小野千晶, 菊地淑恵, 兪志前, 富田博秋

日本神経精神薬理学会年会プログラム・抄録集　46回　224-224　2016/07
Publisher: (一社)日本神経精神薬理学会
恐怖記憶の持続におけるミクログリア由来TNF-αの発現(Role of microglial TNF-alpha in fear memory formation) Peer-reviewed

兪志前, 福島穂高, 小野千晶, 坂井舞, 笠原好之, 菊地淑恵, Gunawansa Nicole, 高橋雄太, 松岡洋夫, 喜田聡, 富田博秋

日本神経精神薬理学会年会プログラム・抄録集　46回　238-238　2016/07
Publisher: (一社)日本神経精神薬理学会
リチウム投与下でのミクログリアと単球の遺伝子発現プロフィールの検討

高橋雄太, 兪志前, 坂井舞, 小松浩, 伊藤文晃, 松岡洋夫, 富田博秋

精神神経学雑誌　(2016特別号)　S481-S481　2016/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
OLIG2遺伝子多型(rs1059004)が脳白質の神経線維束の拡散異方性及び安静時脳灌流量に及ぼす効果の検討 Peer-reviewed

小松浩, 竹内光, 菊地淑恵, 小野千晶, 坂井舞, 小高晃, 舩越俊一, 大野高志, 角藤芳久, 高橋雄太, 松岡洋夫, 瀧靖之, 川島隆太, 富田博秋

精神神経学雑誌　(2016特別号)　S367-S367　2016/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
Linking Activation of Microglia and Peripheral Monocytic Cells to the Pathophysiology of Psychiatric Disorders Peer-reviewed

Yuta Takahashi, Zhiqian Yu, Mai Sakai, Hiroaki Tomita

FRONTIERS IN CELLULAR NEUROSCIENCE　10　Article144　2016/06

DOI： 10.3389/fncel.2016.00144 　

ISSN： 1662-5102
Post-traumatic growth of children affected by the Great East Japan Earthquake and their attitudes to memorial services and media coverage Peer-reviewed

Hirokazu Yoshida, Natsuko Kobayashi, Nami Honda, Hiroo Matsuoka, Takuhiro Yamaguchi, Hiroaki Homma, Hiroaki Tomita

PSYCHIATRY AND CLINICAL NEUROSCIENCES　70　(5)　193-201　2016/05

DOI： 10.1111/pcn.12379 　

ISSN： 1323-1316

eISSN： 1440-1819
Effects of the BDNF Val66Met Polymorphism on Gray Matter Volume in Typically Developing Children and Adolescents Peer-reviewed

Teruo Hashimoto, Kento Fukui, Hikaru Takeuchi, Susumu Yokota, Yoshie Kikuchi, Hiroaki Tomita, Yasuyuki Taki, Ryuta Kawashima

CEREBRAL CORTEX　26　(4)　1795-1803　2016/04

DOI： 10.1093/cercor/bhw020 　

ISSN： 1047-3211

eISSN： 1460-2199
Prospect of future housing and risk of psychological distress at 1 year after an earthquake disaster Peer-reviewed

Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

PSYCHIATRY AND CLINICAL NEUROSCIENCES　70　(4)　182-189　2016/04

DOI： 10.1111/pcn.12377 　

ISSN： 1323-1316

eISSN： 1440-1819
Unemployment risk among individuals undergoing medical treatment for chronic diseases Peer-reviewed

N. Nakaya, T. Nakamura, N. Tsuchiya, I. Tsuji, A. Hozawa, H. Tomita

OCCUPATIONAL MEDICINE-OXFORD　66　(2)　143-149　2016/03

DOI： 10.1093/occmed/kqv159 　

ISSN： 0962-7480

eISSN： 1471-8405
Microglial Gene Expression Alterations in the Brains of Patients with Psychiatric Disorders Peer-reviewed

Mai Sakai, Yuta Takahashi, Zhiqian Yu, Hiroaki Tomita

Advances in Neuroimmune Biology　6　(2)　83-93　2016
Publisher: IOS Press
DOI： 10.3233/NIB-160110 　

ISSN： 1878-9498 1878-948X

eISSN： 1878-9498
Eczema and Asthma Symptoms among Schoolchildren in Coastal and Inland Areas after the 2011 Great East Japan Earthquake: The ToMMo Child Health Study Peer-reviewed

Masako Miyashita, Masahiro Kikuya, Chizuru Yamanaka, Mami Ishikuro, Taku Obara, Yuki Sato, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Hideyasu Kiyomoto, Junichi Sugawara, Atsushi Hozawa, Nobuo Fuse, Yoichi Suzuki, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　237　(4)　297-305　2015/12

DOI： 10.1620/tjem.237.297 　

ISSN： 0040-8727

eISSN： 1349-3329
災害時の妊産褥婦の心理的反応と母子保健・支援活動

小林奈津子, 根本晴美, 佐藤翔輔, 菊地紗耶, 本多奈美, 松岡洋夫, 富田博秋

第12回日本周産期メンタルヘルス学会学術集会　2015/10
Possibilities for a Composite Approach: Summary of the Disaster Gerontology Panel at the International College of Geriatric Psychoneuropharmacology Annual Meeting (ICGP-2014) Peer-reviewed

Adam Lebowitz, Athena Yi-jung Tsai, Brent P. Forester, Hiroaki Tomita, Jun Shigemura, Yoshitomo Takahashi

DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS　9　(5)　478-479　2015/10

DOI： 10.1017/dmp.2015.87 　

ISSN： 1935-7893

eISSN： 1938-744X
Periodontal Disease Is Associated with Insomnia among Victims of the Great East Japan Earthquake: A Panel Study Initiated Three Months after the Disaster Peer-reviewed

Masahiro Tsuchiya, Jun Aida, Yoshihiro Hagiwara, Yumi Sugawara, Yasutake Tomata, Mari Sato, Takashi Watanabe, Hiroaki Tomita, Eiji Nemoto, Makoto Watanabe, Ken Osaka, Ichiro Tsuji

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　237　(2)　83-90　2015/10

DOI： 10.1620/tjem.237.83 　

ISSN： 0040-8727

eISSN： 1349-3329
治療域濃度リチウムによる単球系細胞における遺伝子発現への影響 Peer-reviewed

兪志前, 小野千晶, 相場節也, 菊地淑恵, 曽良一郎, 松岡洋夫, 富田博秋

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集　37回・45回　194-194　2015/09
Publisher: 日本生物学的精神医学会・日本神経精神薬理学会
精神刺激薬によるドパミン作動性神経のホメオスタシス破綻への調節メカニズムモノアミン神経伝達に関わる遺伝子改変マウスを用いた精神疾患研究

笠原好之, 久保有美子, 森屋由紀, 有銘預世布, 富田博秋, 曽良一郎

日本アルコール・薬物医学会雑誌　50　(4)　157-157　2015/08
Publisher: (一社)日本アルコール・アディクション医学会
ISSN： 1341-8963
Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals Peer-reviewed

Masao Nagasaki, Jun Yasuda, Fumiki Katsuoka, Naoki Nariai, Kaname Kojima, Yosuke Kawai, Yumi Yamaguchi-Kabata, Junji Yokozawa, Inaho Danjoh, Sakae Saito, Yukuto Sato, Takahiro Mimori, Kaoru Tsuda, Rumiko Saito, Xiaoqing Pan, Satoshi Nishikawa, Shin Ito, Yoko Kuroki, Osamu Tanabe, Nobuo Fuse, Shinichi Kuriyama, Hideyasu Kiyomoto, Atsushi Hozawa, Naoko Minegishi, James Douglas Engel, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto

NATURE COMMUNICATIONS　6　8018　2015/08

DOI： 10.1038/ncomms9018 　

ISSN： 2041-1723
The Association Between Medical Treatment of Physical Diseases and Psychological Distress After the Great East Japan Earthquake: The Shichigahama Health Promotion Project Peer-reviewed

Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS　9　(4)　374-381　2015/08

DOI： 10.1017/dmp.2015.52 　

ISSN： 1935-7893

eISSN： 1938-744X
Protocol and Research Perspectives of the ToMMo Child Health Study after the 2011 Great East Japan Earthquake Peer-reviewed

Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, Yuki Sato, Taku Obara, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Hideyasu Kiyomoto, Junichi Sugawara, Atsushi Hozawa, Nobuo Fuse, Yoichi Suzuki, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　236　(2)　123-130　2015/06

DOI： 10.1620/tjem.236.123 　

ISSN： 0040-8727

eISSN： 1349-3329
Cognitive and neural correlates of the 5-repeat allele of the dopamine D4 receptor gene in a population lacking the 7-repeat allele. International-journal Peer-reviewed

Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

NeuroImage　110　124-35　2015/04/15

DOI： 10.1016/j.neuroimage.2015.01.053 　

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The 5-repeat allele of a common length polymorphism in the gene that encodes the dopamine D4 receptor (DRD4) is robustly associated with the risk of attention deficit hyperactivity disorder (ADHD) and substantially exists in Asian populations, which have a lower ADHD prevalence. In this study, we investigated the effect of this allele on microstructural properties of the brain and on its functional activity during externally directed attention-demanding tasks and creative performance in the 765 Asian subjects. For this purpose, we employed diffusion tensor imaging, N-back functional magnetic resonance imaging paradigms, and a test to measure creativity by divergent thinking. The 5-repeat allele was significantly associated with increased originality in the creative performance, increased mean diffusivity (the measure of how the tissue includes water molecules instead of neural and vessel components) in the widespread gray and white matter areas of extensive areas, particularly those where DRD4 is expressed, and reduced task-induced deactivation in the areas that are deactivated during the tasks in the course of both the attention-demanding working memory task and simple sensorimotor task. The observed neural characteristics of 5-repeat allele carriers may lead to an increased risk of ADHD and behavioral deficits. Furthermore, the increased originality of creative thinking observed in the 5-repeat allele carriers may support the notion of the side of adaptivity of the widespread risk allele of psychiatric diseases.
Sex differences in the effects of adolescent social deprivation on alcohol consumption in mu-opioid receptor knockout mice Peer-reviewed

Yuki Moriya, Yoshiyuki Kasahara, F. Scott Hall, Yasufumi Sakakibara, George R. Uhl, Hiroaki Tomita, Ichiro Sora

PSYCHOPHARMACOLOGY　232　(8)　1471-1482　2015/04

DOI： 10.1007/s00213-014-3784-y 　

ISSN： 0033-3158

eISSN： 1432-2072
Therapeutic Concentration of Lithium Stimulates Complement C3 Production in Dendritic Cells and Microglia via GSK-3 Inhibition Peer-reviewed

Zhiqian Yu, Chiaki Ono, Setsuya Aiba, Yoshie Kikuchi, Ichiro Sora, Hiroo Matsuoka, Hiroaki Tomita

GLIA　63　(2)　257-270　2015/02

DOI： 10.1002/glia.22749 　

ISSN： 0894-1491

eISSN： 1098-1136
The associations among the dopamine D2 receptor Taq1, emotional intelligence, creative potential measured by divergent thinking, and motivational state and these associations' sex differences. International-journal Peer-reviewed

Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos M Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Frontiers in psychology　6　912-912　2015

DOI： 10.3389/fpsyg.2015.00912 　

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Previous neuroscientific studies have shown that the dopaminergic system plays an important role in creative potential measured by divergent thinking (CPMDT), emotional control, and motivational state. However, although associations between two of these four components have been previously established (e.g., the association between CPMDT and emotional control, the association between CPMDT and motivational state, etc.), the interactions between these four remain unknown. The purpose of this study was to reveal these interactions using path analyses. The Taq1A polymorphism of the dopamine D2 receptor (DRD2) gene was used for this purpose. For measuring emotional intelligence (EI), we used the Japanese version of the Emotional Intelligence Scale. CPMDT was measured using the S-A creativity test. Motivational state was measured using the Vigor subscale of the Japanese version of the Profile of Mood Scale (POMS). Data from 766 healthy, right-handed individuals (426 men and 340 women; 20.7 ± 1.9 years of age) were used in this study. There were significant and robust positive relationships among measures of CPMDT, EI, and motivational state across sex. In addition, the polymorphism of the DRD2 gene was significantly associated with EI, specifically in females. Path analysis in females indicates that the model in which (a) the DRD2 polymorphism primarily facilitates EI, (b) EI in turn facilitates CPMDT and leads to a better motivational state, and (c) a better motivational state also directly facilitates CPMDT explains the data in the most accurate manner. This study suggested a comprehensive picture of the cascade of the associations among dopamine, EI, motivational state, and CPMDT at least in females.
胎生期ストレスが胎児のエピゲノム変化および精神行動に及ぼす影響の特定 Peer-reviewed

兪志前, 舟山亮, 植野和子, 成相直樹, 小島要, 小野千晶, 笠原好之, 長崎正朗, 中山啓子, 富田博秋

日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集　24回・44回　204-204　2014/11
Publisher: 日本臨床精神神経薬理学会・日本神経精神薬理学会
Fluorescently Activated Cell Sorting Followed by Microarray Profiling of Helper T Cell Subtypes from Human Peripheral Blood Peer-reviewed

Chiaki Ono, Zhiqian Yu, Yoshiyuki Kasahara, Yoshie Kikuchi, Naoto Ishii, Hiroaki Tomita

PLOS ONE　9　(11)　e111405-2014　2014/11

DOI： 10.1371/journal.pone.0111405 　

ISSN： 1932-6203
Factors Associated with the Psychological Impact of the Great East Japan Earthquake on High School Students 1 Year and 4 Months after the Disaster Peer-reviewed

Shunichi FUNAKOSHI, Takashi OHNO, Akira KODAKA, Junko OKUYAMA, Nami HONDA, Takao INOUE, Yuki SATO, Maki MIYAJIMA, Hiroaki TOMITA, Kenzou DENDA, Hiroo MATSUOKA

116　(7)　541-554　2014/09
Breakout Session 3 Summary: Psychosocial/Mental Health Concerns and Building Community Resilience Peer-reviewed

Hiroaki Tomita, Robert J. Ursano

DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS　8　(4)　363-365　2014/08

DOI： 10.1017/dmp.2014.68 　

ISSN： 1935-7893

eISSN： 1938-744X
恐怖記憶の再固定化および消去に伴う単球系細胞における遺伝子発現変化の網羅的解析 Peer-reviewed

兪志前, 小野千晶, 福島穂高, 喜田聡, 富田博秋

日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集　23回・43回　240-240　2013/10
Publisher: 日本臨床精神神経薬理学会・日本神経精神薬理学会
G protein-linked signaling pathways in bipolar and major depressive disorders Peer-reviewed

Hiroaki Tomita, Mary E. Ziegler, Helen B. Kim, Simon J. Evans, Prabhakara V. Choudary, Jun Z. Li, Fan Meng, Manhong Dai, Richard M. Myers, Charles R. Neal, Terry P. Speed, Jack D. Barchas, Alan F. Schatzberg, Stanley J. Watson, Huda Akil, Edward G. Jones, William E. Bunney, Marquis P. Vawter

Frontiers in Genetics　4　(4)　1-12　2013

DOI： 10.3389/fgene.2013.00297 　

ISSN： 1664-8021
Expression analysis of a novel mRNA variant of the schizophrenia risk gene ZNF804A Peer-reviewed

Takeya Okada, Ryota Hashimoto, Hidenaga Yamamori, Satomi Umeda-Yano, Yuka Yasuda, Kazutaka Ohi, Motoyuki Fukumoto, Keiko Ikemoto, Yasuto Kunii, Hiroaki Tomita, Akira Ito, Masatoshi Takeda

SCHIZOPHRENIA RESEARCH　141　(2-3)　277-278　2012/11

DOI： 10.1016/j.schres.2012.08.015 　

ISSN： 0920-9964
リチウムの単球系細胞における免疫関連遺伝子の発現誘導(Therapeutic concentration of lithium stimulates immune related gene expressions in differentiated monocytic cells) Peer-reviewed

兪志前, 小野千晶, 相場節也, 曽良一郎, 富田博秋

日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集　22回・42回　195-195　2012/10
Publisher: 日本臨床精神神経薬理学会・日本神経精神薬理学会
Mutations in PRRT2 responsible for paroxysmal kinesigenic dyskinesias also cause benign familial infantile convulsions (vol 57, pg 338, 2012) Peer-reviewed

Ono Shinji, Yoshiura Koh-ichiro, Kinoshita Akira, Kikuchi Taeko, Nakane Yoshibumi, Kato Nobumasa, Sadamatsu Miyuki, Konishi Tohru, Nagamitsu Shinichiro, Matsuura Masato, Yasuda Ayako, Komine Maki, Kanai Kazuaki, Inoue Takeshi, Osamura Toshio, Saito Kayoko, Hirose Shinichi, Koide Hiroyoshi, Tomita Hiroaki, Ozawa Hiroki, Niikawa Norio, Kurotaki Naohiro

JOURNAL OF HUMAN GENETICS　57　(6)　399　2012/06

DOI： 10.1038/jhg.2012.50 　

ISSN： 1434-5161
Mutations in PRRT2 responsible for paroxysmal kinesigenic dyskinesias also cause benign familial infantile convulsions Peer-reviewed

Shinji Ono, Koh-ichiro Yoshiura, Akira Kinoshita, Taeko Kikuchi, Yoshibumi Nakane, Nobumasa Kato, Miyuki Sadamatsu, Tohru Konishi, Shinichiro Nagamitsu, Masato Matsuura, Ayako Yasuda, Maki Komine, Kazuaki Kanai, Takeshi Inoue, Toshio Osamura, Kayoko Saito, Shinichi Hirose, Hiroyoshi Koide, Hiroaki Tomita, Hiroki Ozawa, Norio Niikawa, Naohiro Kurotaki

JOURNAL OF HUMAN GENETICS　57　(5)　338-341　2012/05

DOI： 10.1038/jhg.2012.23 　

ISSN： 1434-5161
Missense mutations in the DNA-binding/dimerization domain of NFIX cause Sotos-like features Peer-reviewed

Yuriko Yoneda, Hirotomo Saitsu, Mayumi Touyama, Yoshio Makita, Akie Miyamoto, Keisuke Hamada, Naohiro Kurotaki, Hiroaki Tomita, Kiyomi Nishiyama, Yoshinori Tsurusaki, Hiroshi Doi, Noriko Miyake, Kazuhiro Ogata, Kenji Naritomi, Naomichi Matsumoto

JOURNAL OF HUMAN GENETICS　57　(3)　207-211　2012/03

DOI： 10.1038/jhg.2012.7 　

ISSN： 1434-5161
Four mood stabilizers commonly induce FEZ1 expression in human astrocytes Peer-reviewed

Zhiqian Yu, Chiaki Ono, Helen B. Kim, Hiroshi Komatsu, Yoichiro Tanabe, Nobutaka Sakae, Keiichi I. Nakayama, Hiroo Matsuoka, Ichiro Sora, William E. Bunney, Hiroaki Tomita

BIPOLAR DISORDERS　13　(5-6)　486-499　2011/08

DOI： 10.1111/j.1399-5618.2011.00946.x 　

ISSN： 1398-5647
双極性障害治療薬のアストロサイトにおける発現プロファイルへの影響． Peer-reviewed

兪志前, 小野千晶, 田邊陽一郎, 小松浩, 松岡洋夫, 曽良一郎, 富田博秋

Bipolar Disorder研究会年会報　9　13-14　2011/05
Publisher:
Effect of chronic lithium treatment on gene expression profile in mouse microglia and brain dendritic cells Peer-reviewed

Zhiqian Yu, Chiaki Ono, Ichiro Sora, Hiroaki Tomita

Japanese Journal of Neuropsychopharmacology　31　(2)　101-102　2011/04

ISSN： 1340-2544
Identification of novel transcription factors for catecholamine gene expression based upon the comprehensive analyses of transcripts in fetal pontine noradrenergic neurons using trasngenic mice expressing green fluorescent protein under the promoter of tyrosine hydroxylase Peer-reviewed

Haruka Yokohashi, Katsuya Uchida, Toshimitsu Fuse, Yasumasa Iwasaki, Kengo Kinoshita, Akira Okazaki, Gopal Das, Keisuke Sawada, Chiaki Tanaka, Hiroaki Tomita, Shinji Ohara, Kazuto Kobayashi, Keiichi Itoi

NEUROSCIENCE RESEARCH　71　E120-E120　2011
Publisher: ELSEVIER IRELAND LTD
DOI： 10.1016/j.neures.2011.07.514 　
Effect of chronic lithium treatment on gene expression profile in mouse microglia and brain dendritic cells Invited

Zhiqian Yu, Chiaki Ono, Yoichiro Tanabe, Ichiro Sora, Hiroaki Tomita

NEUROSCIENCE RESEARCH　71　(2)　E122-E122　2011

DOI： 10.1016/j.neures.2011.07.522 　

ISSN： 0168-0102
気分安定薬バルプロ酸およびラモトリギン投与によるヒト脳細胞遺伝子発現変化のマイクロアレイ解析による包括的検討

田邊陽一郎, 田中千晶, 兪志前, 小松浩, 木村好, 羽藤愛, 松岡洋夫, 曽良一郎, 富田博秋

Bipolar Disorder　8　61-69　2010/06
Publisher: アルタ出版(株)
気分安定薬奏功機序解明のための包括的遺伝子発現解析． Peer-reviewed

富田博秋, 田中千秋, 兪志前, 小松浩, 木村好, 曽良一郎, Helen B. Kim William E. Bunney

臨床薬理の進歩　30　(30)　52-59　2009/07
Publisher:
ISSN： 0914-4366
MONOAMINE TRANSPORTER AS A TARGET MOLECULE FOR PSYCHOSTIMULANTS Peer-reviewed

Ichiro Sora, BingJin Li, Setsu Fumushima, Asami Fukui, Yosefu Arime, Yoshiyuki Kasahara, Hiroaki Tomita, Kazutaka Ikeda

ADVANCES IN NEUROPHARMACOLOGY　85　29-33　2009

DOI： 10.1016/S0074-7742(09)85003-4 　

ISSN： 0074-7742
Sample matching by inferred agonal stress in gene expression analyses of the brain Peer-reviewed

Jun Z. Li, Fan Meng, Larisa Tsavaler, Simon J. Evans, Prabhakara V. Choudary, Hiroaki Tomita, Marquis P. Vawter, David Walsh, Vida Shokoohi, Tisha Chung, William E. Bunney, Edward G. Jones, Huda Akil, Stanley J. Watson, Richard M. Myers

BMC GENOMICS　8　(1)　336-373　2007/09

DOI： 10.1186/1471-2164-8-336 　

ISSN： 1471-2164
Methodological considerations for gene expression profiling of human brain Peer-reviewed

Mary Atz, David Walsh, Preston Cartagena, Jun Li, Simon Evans, Prabhakara Choudary, Kevin Overman, Richard Stein, Hiro Tomita, Steven Potkin, Rick Myers, Stanley J. Watson, E. G. Jones, Huda Akil, William E. Bunney, Marquis P. Vawter

JOURNAL OF NEUROSCIENCE METHODS　163　(2)　295-309　2007/07

DOI： 10.1016/j.jneumeth.2007.03.022 　

ISSN： 0165-0270

eISSN： 1872-678X
Paroxysmal kinesigenic choreoathetosis (PKC): confirmation of linkage to 16p11-q21, but unsuccessful detection of mutations among 157 genes at the PKC-critical region in seven PKC families Peer-reviewed

Taeko Kikuchi, Masayo Nomura, Hiroaki Tomita, Naoki Harada, Kazuaki Kanai, Tohru Konishi, Ayako Yasuda, Masato Matsuura, Nobumasa Kato, Koh-ichiro Yoshiura, Norio Niikawa

JOURNAL OF HUMAN GENETICS　52　(4)　334-341　2007/04

DOI： 10.1007/s10038-007-0116-7 　

ISSN： 1434-5161
Mitochondrial-related gene expression changes are sensitive to agonal-pH state: implications for brain disorders Peer-reviewed

MP Vawter, H Tomita, F Meng, B Bolstad, J Li, S Evans, P Choudary, M Atz, L Shao, C Neal, DM Walsh, M Burmeister, T Speed, R Myers, EG Jones, SJ Watson, H Akil, WE Bunney

MOLECULAR PSYCHIATRY　11　(7)　663-679　2006/07

DOI： 10.1038/sj.mp.4001830 　

ISSN： 1359-4184
A SNP in the ABCC11 gene is the determinant of human earwax type Peer-reviewed

K Yoshiura, A Kinoshita, T Ishida, A Ninokata, T Ishikawa, T Kaname, M Bannai, K Tokunaga, S Sonoda, R Komaki, M Ihara, VA Saenko, GK Alipov, Sekine, I, K Komatsu, H Takahashi, M Nakashima, N Sosonkina, CK Mapendano, M Ghadami, M Nomura, DS Liang, N Miwa, DK Kim, A Garidkhuu, N Natsume, T Ohta, H Tomita, A Kaneko, M Kikuchi, G Russomando, K Hirayama, M Ishibashi, A Takahashi, N Saitou, JC Murray, S Saito, Y Nakamura, N Niikawa

NATURE GENETICS　38　(3)　324-330　2006/03

DOI： 10.1038/ng1733 　

ISSN： 1061-4036
Application of microarray technology in primate behavioral neuroscience research Peer-reviewed

AM Karssen, JZ Li, S Her, PD Patel, F Meng, SJ Evans, MP Vawter, H Tomita, PV Choudary, WE Bunney, EG Jones, SJ Watson, H Akil, RM Myers, AF Schatzberg, DM Lyons

METHODS　38　(3)　227-234　2006/03

DOI： 10.1016/j.ymeth.2005.09.017 　

ISSN： 1046-2023

eISSN： 1095-9130
Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression Peer-reviewed

PV Choudary, M Molnar, SJ Evans, H Tomita, JZ Li, MP Vawter, RM Myers, WE Bunney, H Akil, SJ Watson, EG Jones

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　102　(43)　15653-15658　2005/10

DOI： 10.1073/pnas.0507901102 　

ISSN： 0027-8424
Dysregulation of the fibroblast growth factor system in major depression Peer-reviewed

SJ Evans, PV Choudary, CR Neal, JZ Li, MP Vawter, H Tomita, JF Lopez, RC Thompson, F Meng, JD Stead, DM Walsh, RM Myers, WE Bunney, SJ Watson, EG Jones, H Akil

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　101　(43)　15506-15511　2004/10

DOI： 10.1076/pnas.0406788101 　

ISSN： 0027-8424
Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions Peer-reviewed

JZ Li, MP Vawter, DM Walsh, H Tomita, SJ Evans, PV Choudary, JF Lopez, A Avelar, Shokoohi, V, T Chung, O Mesarwi, EG Jones, SJ Watson, H Akil, WE Bunney, RM Myers

HUMAN MOLECULAR GENETICS　13　(6)　609-616　2004/03

DOI： 10.1093/hmg/ddh065 　

ISSN： 0964-6906
An apamin- and scyllatoxin-insensitive isoform of the human SK3 channel Peer-reviewed

OH Wittekindt, Visan, V, H Tomita, F Imtiaz, JJ Gargus, F Lehmann-Horn, S Grissmer, DJ Morris-Rosendahl

MOLECULAR PHARMACOLOGY　65　(3)　788-801　2004/03

DOI： 10.1124/mol.65.3.788 　

ISSN： 0026-895X
Gender-specific gene expression in post-mortem human brain: Localization to sex chromosomes Peer-reviewed

MP Vawter, S Evans, P Choudary, H Tomita, J Meador-Woodruff, M Molnar, J Li, JF Lopez, R Myers, D Cox, SJ Watson, H Akil, EG Jones, WE Bunney

NEUROPSYCHOPHARMACOLOGY　29　(2)　373-384　2004/02

DOI： 10.1038/sj.npp.1300337 　

ISSN： 0893-133X

eISSN： 1740-634X
SK3-1C, a dominant-negative suppressor of SKCa and IKCa channels Peer-reviewed

A Kolski-Andreaco, H Tomita, VG Shakkottai, GA Gutman, MD Cahalan, JJ Gargus, KG Chandy

JOURNAL OF BIOLOGICAL CHEMISTRY　279　(8)　6893-6904　2004/02

DOI： 10.1074/jbc.M311725200 　

ISSN： 0021-9258
Effect of agonal and postmortem factors on gene expression profile: Quality control in microarray analyses of postmortem human brain Peer-reviewed

H Tomita, MP Vawter, DM Walsh, SJ Evans, PV Choudary, J Li, KM Overman, ME Atz, RM Myers, EG Jones, SJ Watson, H Akil, WE Bunney

BIOLOGICAL PSYCHIATRY　55　(4)　346-352　2004/02

DOI： 10.1016/j.biopsych.2003.10.013 　

ISSN： 0006-3223
LRP5, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density Peer-reviewed

Takeshi Mizuguchi, Itsuko Furuta, Yukio Watanabe, Kazuhiro Tsukamoto, Hiroshi Tomita, Mitsuhiro Tsujihata, Tohru Ohta, Tatsuya Kishino, Naomichi Matsumoto, Hisanori Minakami, Norio Niikawa, Koh-Ichiro Yoshiura

Journal of Human Genetics　49　(2)　80-86　2004

DOI： 10.1007/s10038-003-0111-6 　

ISSN： 1434-5161
Microarray technology: A review of new strategies to discover candidate vulnerability genes in psychiatric disorders Peer-reviewed

WE Bunney, BG Bunney, MP Vawter, H Tomita, J Li, SJ Evans, PV Choudary, RM Myers, EG Jones, SJ Watson, H Akil

AMERICAN JOURNAL OF PSYCHIATRY　160　(4)　657-666　2003/04

DOI： 10.1176/appi.ajp.160.4.657 　

ISSN： 0002-953X
Novel truncated isoform of SK3 potassium channel is a potent dominant-negative regulator of SK currents: implications in schizophrenia Peer-reviewed

H Tomita, VG Shakkottai, GA Gutman, G Sun, WE Bunney, MD Cahalan, KG Chandy, JJ Gargus

MOLECULAR PSYCHIATRY　8　(5)　524-535　2003

DOI： 10.1038/sj.mp.4001271 　

ISSN： 1359-4184

eISSN： 1476-5578
Mapping of the wet/dry earwax locus to the pericentromeric region of chromosome 16 Peer-reviewed

H Tomita, K Yamada, M Ghadami, T Ogura, Y Yanai, K Nakatomi, M Sadamatsu, A Masui, N Kato, N Niikawa

LANCET　359　(9322)　2000-2002　2002/06

DOI： 10.1016/S0140-6736(02)08835-9 　

ISSN： 0140-6736
Haploinsufficiency of NSD1 causes Sotos syndrome Peer-reviewed

N Kurotaki, K Imaizumi, N Harada, M Masuno, T Kondoh, T Nagai, H Ohashi, K Naritomi, M Tsukahara, Y Makita, T Sugimoto, T Sonoda, T Hasegawa, Y Chinen, H Tomita, A Kinoshita, T Mizuguchi, K Yoshiura, T Ohta, T Kishino, Y Fukushima, N Niikawa, N Matsumoto

NATURE GENETICS　30　(4)　365-366　2002/04

DOI： 10.1038/ng863 　

ISSN： 1061-4036
A novel gene is disrupted at a 14q13 breakpoint of t(2;14) in a patient with mirror-image polydactyly of hands and feet Peer-reviewed

S Kondoh, H Sugawara, N Harada, N Matsumoto, H Ohashi, M Sato, PN Kantaputra, T Ogino, H Tomita, T Ohta, T Kishino, Y Fukushima, N Niikawa, K Yoshiura

JOURNAL OF HUMAN GENETICS　47　(3)　136-139　2002

DOI： 10.1007/s100380200015 　

ISSN： 1434-5161
Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2 Peer-reviewed

VG Shakkottai, Regaya, I, H Wulff, Z Fajloun, H Tomita, M Fathallah, MD Cahalan, JJ Gargus, JM Sabatier, KG Chandy

JOURNAL OF BIOLOGICAL CHEMISTRY　276　(46)　43145-43151　2001/11

DOI： 10.1074/jbc.M106981200 　

ISSN： 0021-9258
Confirmation of genetic homogeneity of syndactyly type 1 in an Iranian family Peer-reviewed

M Ghadami, K Majidzadeh-A, BS Haerian, E Damavandi, K Yamada, P Pasallar, MT Najafi, G Nishimura, HA Tomita, KI Yoshiura, N Niikawa

AMERICAN JOURNAL OF MEDICAL GENETICS　104　(2)　147-151　2001/11

DOI： 10.1002/ajmg.10061 　

ISSN： 0148-7299
Nuclear localization and dominant-negative suppression by a mutant SKCa3N-terminal channel fragment identified in a patient with schizophrenia Peer-reviewed

MJ Miller, H Rauer, H Tomita, H Rauer, JJ Gargus, GA Gutman, MD Cahalan, KG Chandy

JOURNAL OF BIOLOGICAL CHEMISTRY　276　(30)　27753-27756　2001/07

DOI： 10.1074/jbc.C100221200 　

ISSN： 0021-9258
Genomic organization and promoter analysis of human KCNN3 gene Peer-reviewed

GF Sun, H Tomita, VG Shakkottai, JJ Gargus

JOURNAL OF HUMAN GENETICS　46　(8)　463-470　2001

DOI： 10.1007/s100380170046 　

ISSN： 1434-5161
Erratum: finckh U, Schroder J, ressler B, veske A, gal A. Spectrum and detection rate of L1CAM mutations in isolated and familial cases with clinically suspected L1-disease. Am J med genet 92:40-46 Peer-reviewed

Ghadami M, Tomita HA, Najafi MT, Damavandi E, Farahvash MS, Yamada K, Majidzadeh-A K, Niikawa N

Am J Med Genet　94　(5)　438-438　2000/10/23

DOI： 10.1002/1096-8628(20001023)94:5<438::AID-AJMG18>3.0.CO;2-F
Bardet-Biedl syndrome type 3 in an Iranian family: Clinical study and confirmation of disease localization Peer-reviewed

M Ghadami, HA Tomita, MT Najafi, E Damavandi, MS Farahvash, K Yamada, K Majidzadeh-A, N Niikawa

AMERICAN JOURNAL OF MEDICAL GENETICS　94　(5)　433-437　2000/10

DOI： 10.1002/1096-8628(20001023)94:5<433::AID-AJMG17>3.0.CO;2-X 　

ISSN： 0148-7299
Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease Peer-reviewed

A Kinoshita, T Saito, H Tomita, Y Makita, K Yoshida, M Ghadami, K Yamada, S Kondo, S Ikegawa, G Nishimura, Y Fukushima, T Nakagomi, H Saito, T Sugimoto, M Kamegaya, K Hisa, JC Murray, N Taniguchi, N Niikawa, K Yoshiura

NATURE GENETICS　26　(1)　19-20　2000/09

DOI： 10.1038/79128 　

ISSN： 1061-4036
An autosomal dominant posterior polar cataract locus maps to human chromosome 20pl 12-q12 Peer-reviewed

K Yamada, H Tomita, K Yoshiura, S Kondo, K Wakui, Y Fukushima, S Ikegawa, Y Nakamura, T Amemiya, N Niikawa

EUROPEAN JOURNAL OF HUMAN GENETICS　8　(7)　535-539　2000/07

DOI： 10.1038/sj.ejhg.5200485 　

ISSN： 1018-4813
Genetically distinct autosomal dominant posterior polar cataract in a four-generation Japanese family Peer-reviewed

K Yamada, HA Tomita, S Kanazawa, A Mera, T Amemiya, N Niikawa

AMERICAN JOURNAL OF OPHTHALMOLOGY　129　(2)　159-165　2000/02

DOI： 10.1016/S0002-9394(99)00313-X 　

ISSN： 0002-9394
Genetic mapping of the Camurati-Engelmann disease locus to chromosome 19q13.1-q13.3 Peer-reviewed

M Ghadami, Y Makita, K Yoshida, G Nishimura, Y Fukushima, K Wakui, S Ikegawa, K Yamada, S Kondo, N Niikawa, H Tomita

AMERICAN JOURNAL OF HUMAN GENETICS　66　(1)　143-147　2000/01

DOI： 10.1086/302728 　

ISSN： 0002-9297
Paroxysmal kinesigenic choreoathetosis locus maps to chromosome 16p11.2-q12.1 Peer-reviewed

H Tomita, S Nagamitsu, K Wakui, Y Fukushima, K Yamada, M Sadamatsu, A Masui, T Konishi, T Matsuishi, M Aihara, K Shimizu, K Hashimoto, M Mineta, M Matsushima, T Tsujita, M Saito, H Tanaka, S Tsuji, T Takagi, Y Nakamura, S Nanko, N Kato, Y Nakane, N Niikawa

AMERICAN JOURNAL OF HUMAN GENETICS　65　(6)　1688-1697　1999/12

DOI： 10.1086/302682 　

ISSN： 0002-9297
Maternal uniparental disomy for chromosome 14 in a boy with intrauterine growth retardation Peer-reviewed

O Miyoshi, S Hayashi, M Fujimoto, H Tomita, M Sohda, N Niikawa

JOURNAL OF HUMAN GENETICS　43　(2)　138-142　1998

DOI： 10.1007/s100380050056 　

ISSN： 1434-5161
The gene for mesomelic dysplasia Kantaputra type is mapped to chromosome 2q24-q32 Peer-reviewed

M Fujimoto, PN Kantaputra, S Ikegawa, Y Fukushima, S Sonta, M Matsuo, T Ishida, T Matsumoto, S Kondo, H Tomita, HX Deng, M D'urso, MM Rinaldi, Ventruto, V, T Takagi, Y Nakamura, N Niikawa

JOURNAL OF HUMAN GENETICS　43　(1)　32-36　1998

DOI： 10.1007/s100380050033 　

ISSN： 1434-5161
A 1.2-megabase BAC/PAC contig spanning the 14q13 breakpoint of t(2;14) in a mirror-image polydactyly patient Peer-reviewed

N Matsumoto, E Soeda, H Ohashi, M Fujimoto, R Kato, T Tsujita, H Tomita, S Kondo, Y Fukushima, N Niikawa

GENOMICS　45　(1)　11-16　1997/10

DOI： 10.1006/geno.1997.4897 　

ISSN： 0888-7543
Polymorphism of dopamine receptors and transporter genes in neuropsychiatric diseases Peer-reviewed

Y Fujiwara, K Yamaguchi, Y Tanaka, H Tomita, Y Shiro, K Kashihara, K Sato, S Kuroda

EUROPEAN NEUROLOGY　38　6-10　1997

ISSN： 0014-3022
Characterization of the promoter region, first ten exons and nine intron-exon boundaries of the DNA-dependent protein kinase catalytic subunit gene, DNA-PKcs (XRCC7) Peer-reviewed

Masahiro Fujimoto, Naomichi Matsumoto, Takahiro Tsujita, Hiroaki Tomita, Shinji Kondo, Noriko Miyake, Motoi Nakano, Norio Niikawa

DNA Research　4　(2)　151-154　1997
Publisher: Universal Academy Press Inc.
DOI： 10.1093/dnares/4.2.151 　

ISSN： 1340-2838
CHANGES IN DOPAMINE D-2 AND GLUR-1 GLUTAMATE-RECEPTOR MESSENGER-RNAS IN THE RAT-BRAIN AFTER TREATMENT WITH PHENCYCLIDINE Peer-reviewed

H TOMITA, M HIKIJI, Y FUJIWARA, K AKIYAMA, S OTSUKI

ACTA MEDICA OKAYAMA　49　(2)　61-68　1995/04

DOI： 10.18926/AMO/30393 　

ISSN： 0386-300X
INCREASE OF KAINATE RECEPTOR MESSENGER-RNA IN THE HIPPOCAMPAL CA3 OF AMYGDALA-KINDLED RATS DETECTED BY IN-SITU HYBRIDIZATION Peer-reviewed

M HIKIJI, H TOMITA, M ONO, Y FUJIWARA, K AKIYAMA

LIFE SCIENCES　53　(10)　857-864　1993

DOI： 10.1016/0024-3205(93)90508-Z 　

ISSN： 0024-3205
CHARACTERIZATION OF A CLONED RAT SEROTONIN 5-HT1A RECEPTOR EXPRESSED IN THE HELA-CELL LINE Peer-reviewed

Y FUJIWARA, H TOMITA, M HIKIJI, K KASHIHARA, S OTSUKI, T OHNUKI, Y HAMAGISHI, T OKI, SORA, I, WR ROESKE, HI YAMAMURA

LIFE SCIENCES　52　(11)　949-958　1993

DOI： 10.1016/0024-3205(93)90530-G 　

ISSN： 0024-3205
LACK OF EFFECT OF HALOPERIDOL OR METHAMPHETAMINE TREATMENT ON THE MESSENGER-RNA LEVELS OF 2 DOPAMINE D(2)-RECEPTOR ISOFORMS IN RAT-BRAIN Peer-reviewed

SORA, I, Y FUJIWARA, H TOMITA, H ISHIZU, K AKIYAMA, S OTSUKI, HI YAMAMURA

JAPANESE JOURNAL OF PSYCHIATRY AND NEUROLOGY　46　(4)　967-973　1992/12

ISSN： 0912-2036
Lack of Effect of Haloperidol or Methamphetamine Treatment on the mRNA Levels of Two Dopamine D, Receptor Isoforms in Rat Brain Peer-reviewed

Ichiro Sora, Yutaka Fujiwara, Hiroaki Tomita, Hideki Ishizu, Kazufumi Akiyama, Saburo Otsuki, Henry I. Yamamura

Psychiatry and Clinical Neurosciences　46　(4)　967-973　1992

DOI： 10.1111/j.1440-1819.1992.tb02868.x 　

ISSN： 1440-1819 1323-1316
LOCALIZATION OF THE MESSENGER-RNAS FOR 2 DOPAMINE D2-RECEPTOR ISOFORMS IN THE RAT-BRAIN Peer-reviewed

Y FUJIWARA, SORA, I, H TOMITA, K AKIYAMA, S OTSUKI, HI YAMAMURA

JAPANESE JOURNAL OF PSYCHIATRY AND NEUROLOGY　45　(4)　897-902　1991/12

ISSN： 0912-2036
Localization of the mRNAs for Two Dopamine D2 Receptor Isoforms in the Rat Brain Peer-reviewed

Yutaka Fujiwara, Ichiro Sora, Hiroaki Tomita, Kazufumi Akiyama, Saburo Otsuki, Henry I. Yamamura

Psychiatry and Clinical Neurosciences　45　(4)　897-902　1991

DOI： 10.1111/j.1440-1819.1991.tb00530.x 　

ISSN： 1440-1819 1323-1316

Show all ︎Show first 5

Misc. 146

日本人のための,より安全なクロザピン導入プロトコルの検討

菊地佑樹, 菊地佑樹, 小松浩, 富田博秋

統合失調症研究(CD-ROM)　13　(1)　2024
クロザピンの血中濃度変動における有機アニオン輸送ポリペプチドの関与

佐藤紀宏, 公文代將希, 林和未, 小野口豪, 小松浩, 平塚真弘, 平塚真弘, 前川正充, 前川正充, 富田博秋, 眞野成康, 眞野成康

臨床化学(Web)　53　2024

ISSN： 0370-5633
幻覚妄想状態を呈し措置入院となったことを機に遺伝性脊髄小脳変性症の診断に至った1例

村上桂一, 村上桂一, 小松浩, 大塚達以, 富田博秋

精神神経学雑誌　126　(6)　2024

ISSN： 0033-2658
母親の妊娠中と産後の心理的苦痛と4歳時点における児の発達との関連三世代コホート調査

高橋一平, 小原拓, 菊地紗耶, 小林美佳, 石黒真美, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 松崎芙実子, 小林奈津子, 濱田裕貴, 岩間憲之, 齋藤昌利, 菅原準一, 富田博秋, 呉繁夫, 八重樫伸生, 栗山進一

DOHaD研究　11　(3)　29-29　2023/08
Publisher: (一社)日本DOHaD学会
ISSN： 2187-2562

eISSN： 2187-2597
クロザピンの作用機序—Mechanism of action responsible for superior efficacy of clozapine—特集統合失調症診療のフロントライン(Part 1)

國井泰人, 日野瑞城, 富田博秋

臨床精神医学 = Japanese journal of clinical psychiatry　52　(4)　425-432　2023/04
Publisher: 東京 : アークメディア
ISSN： 0300-032X
死後脳を用いた統合失調症研究—Schizophrenia Research Using Post-mortem Brains—特集わが国の若手による統合失調症研究最前線

國井泰人, 日野瑞城, 富田博秋

精神医学 = Clinical psychiatry　65　(4)　417-424　2023/04
Publisher: 東京 : 医学書院
ISSN： 0488-1281
自然災害下での精神的負担と不調—Mental burden and disorders under post-disaster settings of natural disasters—特集災害・戦争と精神科

富田博秋, 國井泰人, 濱家由美子, 日野瑞城, 栗山進一

精神科 = Psychiatry / 精神科編集委員会編　42　(2)　261-268　2023/02

ISSN： 1347-4790
Mental burden and disorders under post-disaster settings of natural disasters.

富田博秋, 富田博秋, 國井泰人, 濱家由美子, 日野瑞城, 栗山進一

月刊精神科　42　(2)　2023

ISSN： 1347-4790
Expression changes in molecules related to DNA double-strand break repair in a high stress response group of schizophrenia.

宍戸理紗, 日野瑞城, 日野瑞城, 長岡敦子, 長岡敦子, 林秀樹, 柿田明美, 三浦至, 富田博秋, 國井泰人, 國井泰人

日本生物学的精神医学会(Web)　45th　2023
Gene expression analysis of ZDHHC family of protein S-palmitoylating enzymes in postmortem brains of patients with schizophrenia

細貝優人, 日野瑞城, 日野瑞城, 宍戸理紗, 長岡敦子, 長岡敦子, 林秀樹, 柿田明美, 富田博秋, 三浦至, 國井泰人, 國井泰人

日本生物学的精神医学会(Web)　45th　2023
Evaluation of the influence of confounding factors in comprehensive gene expression analysis of human postmortem brain

旗野将貴, 宮原一総, 日野瑞城, 日野瑞城, 長岡敦子, 長岡敦子, 兪志前, 林秀樹, 柿田明美, 富田博秋, 三浦至, 國井泰人, 國井泰人

日本生物学的精神医学会(Web)　45th　2023
精神科リエゾンにおけるトラウマインフォームド・ケアが有効であった一例

瀬戸萌, 佐藤祐太朗, 五十嵐江美, 内海裕介, 冨本和歩, 坪田瑠美, 佐久間篤, 富田博秋, 富田博秋

総合病院精神医学　35　(Supplement (Nov))　2023

ISSN： 0915-5872
気分障害死後脳研究の最前線—Recent advances in postmortem brain studies for mood disorders—特集臨床につながる気分障害研究最前線

國井泰人, 日野瑞城, 富田博秋

臨床精神医学 = Japanese journal of clinical psychiatry　51　(10)　1151-1157　2022/10

ISSN： 0300-032X
OPRM1 rs1799971 polymorphism has an ethnicity-dependent impact on risk for schizophrenia by disturbing the opioids system: A Meta-analysis and Postmortem Brain Study

宮原一総, 日野瑞城, 日野瑞城, 宍戸理紗, 泉竜太, 長岡敦子, 柿田明美, 矢部博興, 富田博秋, 富田博秋, 國井泰人, 國井泰人

日本生物学的精神医学会(Web)　44th　2022
クライネレビン症候群と考えられた症例過眠後半期と間欠期における終夜睡眠ポリソムノグラフィの比較

尾之内勇治, 尾之内勇治, 冨本和歩, 佐久間篤, 大塚達以, 大塚達以, 富田博秋, 富田博秋

臨床神経生理学(Web)　50　(5)　2022

ISSN： 2188-031X
東日本大震災被災地域住民のレジリエンスの変遷の検討

松木佑, 中川高, 内海裕介, 内海裕介, 瀬戸萌, 佐久間篤, 本多奈美, 本多奈美, 富田博秋, 富田博秋, 富田博秋

精神神経学雑誌　124　(10)　2022

ISSN： 0033-2658
東日本大震災被災地域の子どもの睡眠状況の変化とメンタルヘルスとの関連について

松木佑, 吉田弘和, 北川佳奈, 遠藤愛子, 小林奈津子, 菊地紗耶, 本多奈美, 大塚達以, 富田博秋, 富田博秋

日本児童青年精神医学会総会抄録(Web)　62nd　2021
悲嘆反応により顕著な機能障害を来した配偶者遺族に早期から行動活性化療法的アプローチを試みた1例

五十嵐江美, 濱家由美子, 桂雅宏, 富田博秋

日本サイコオンコロジー学会総会プログラム・抄録集　34th (Web)　2021
躁状態で発症し,オランザピンが奏効した産褥精神病の1例

小野寺文一郎, 田坂有香, 大塚達以, 菊地紗耶, 小林奈津子, 小林奈津子, 富田博秋, 富田博秋

精神神経学雑誌　123　(6)　2021

ISSN： 0033-2658
救急医療と精神科との連携 : 東北大学病院精神科リエゾンチームの活動 (第27回日本精神科救急学会総会シンポジウム) -- (特集救急医療における身体科-精神科との連携医療圏の特性に応じた最適解を探る : 宮城県の事例を通じて)

佐久間篤, 鴇田百合子, 内海裕介, 八木橋真央, 宮川乃理子, 工藤大介, 中川敦寛, 富田博秋

精神科救急 : 日本精神科救急学会誌 = Emergency psychiatry : the journal of the Japanese Association for emergency psychiatry　24　(23)　39-42　2020/09
Publisher: 日本精神科救急学会
ISSN： 1345-7837
宮城県における東日本大震災被災者の健康状態等に関する調査七ヶ浜町における被災者の健康状態の推移に関する研究

富田博秋, 内海裕介, 瀬戸萌, 佐久間篤, 臼倉瞳

宮城県における東日本大震災被災者の健康状態等に関する調査令和元年度総括・分担研究報告書(Web)　2020
宮城県における東日本大震災被災者の健康状態等に関する調査被災者健康調査の実施と分析

辻一郎, 押谷仁, 八重樫伸生, 永富良一, 井樋栄二, 富田博秋, 菅原由美, 萩原嘉廣, 矢部裕, 関口拓矢, 松本和紀, 佐久間篤, 瀬戸萌, 内海裕介, 臼倉瞳

宮城県における東日本大震災被災者の健康状態等に関する調査令和元年度総括・分担研究報告書(Web)　2020
早期精神症における大脳白質微細構造と幻覚との関連

佐藤祐太朗, 佐久間篤, 大室則幸, 桂雅宏, 阿部光一, 冨本和歩, 飯塚邦夫, 松岡洋夫, 富田博秋, 松本和紀

精神神経学雑誌　(2019特別号)　S472-S472　2019/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
早期精神症における大脳白質微細構造と幻覚との関連

佐藤祐太朗, 佐藤祐太朗, 佐久間篤, 大室則幸, 桂雅宏, 阿部光一, 冨本和歩, 飯塚邦夫, 松岡洋夫, 松岡洋夫, 富田博秋, 富田博秋, 富田博秋, 松本和紀, 松本和紀

日本精神神経学会総会プログラム・抄録集　115th　(2019特別号)　S.472-S472　2019/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
東日本大震災が沿岸地域の就労と精神的健康に及ぼした影響

片柳光昭, 富田博秋, 瀬戸萌, 根本晴美, 奥山純子, 鈴木智美, 菅原由美, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 小高晃, 辻一郎, 寳澤篤

精神神経学雑誌　(2019特別号)　S753-S753　2019/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
東日本大震災による津波避難訓練の有効性

中谷直樹, 根本晴美, YI Carine J, 佐藤文子, 新宮古都美, 庄子朋香, 佐藤翔輔, 土屋菜歩, 中村智洋, 成田暁, 小暮真奈, 菅原由美, 兪志前, GUNAWANSA Nicole, 栗山進一, 村尾修, 佐藤健, 今村文彦, 富田博秋

宮城県公衆衛生学会会誌　(51)　12　2019/03

ISSN： 0912-747X
災害(テロ災害・検証) 爆風損傷臨床、診療体制、課題

中川敦寛, ロッコ・アーモンダ, 大谷清伸, ガイ・ローゼンタール, 刈部博, 冨田博秋, 佐久間篤, 八木橋真央, ジェフリー・マンレー, 久志本成樹, 冨永悌二

Neurosurgical Emergency　23　(3)　279-279　2019/02
Publisher: (NPO)日本脳神経外科救急学会
ISSN： 1342-6214
スポーツ神経外傷の課題と対応学校における脳振盪教育現場の実情と課題

中川敦寛, 刈部博, 荻野雅宏, 八木橋真央, 中山晴雄, 望月浩一郎, 佐久間篤, 大沢伸一郎, 冨田博秋, 久志本成樹, 冨永悌二

日本脳神経外傷学会プログラム・抄録集　42回　66-66　2019/02
Publisher: (一社)日本脳神経外傷学会
頭部外傷後の患者への精神科介入判断に関する考察質と量的データの関連から

八木橋真央, 佐久間篤, 中川敦寛, 麦倉俊司, 古谷桂子, 工藤大介, 大沢伸一郎, 久志本成樹, 冨永悌二, 富田博秋

日本脳神経外傷学会プログラム・抄録集　42回　115-115　2019/02
Publisher: (一社)日本脳神経外傷学会
脳神経外傷の画像診断びまん性軸索損傷の診断に関する来院時CTの意義

中川敦寛, 麦倉俊司, 今井啓道, 八木橋真央, 佐久間篤, 大沢伸一郎, 工藤大介, 刈部博, 近田祐介, 冨田博秋, 久志本成樹, 冨永悌二

日本脳神経外傷学会プログラム・抄録集　42回　61-61　2019/02
Publisher: (一社)日本脳神経外傷学会
宮城県における東日本大震災被災者の健康状態等に関する調査被災者健康調査の実施と分析

辻一郎, 遠又靖丈, 菅原由美, 丹治史也, 大塚達以, 松元浩一, 押谷仁, 富田博秋, 松本和紀, 八重樫伸生, 永富良一, 井樋栄二, 萩原嘉廣, 佐々木啓一, 小坂健, 相田潤, 奥山純子, 金村政輝, 粟田主一, 鈴木玲子, 曽根稔雅

宮城県における東日本大震災被災者の健康状態等に関する調査平成30年度総括・分担研究報告書(Web)　2019
オリゴデンドロサイト関連遺伝子多型(rs1059004)と自己スキーマ及び抑うつ症状との相関研究

小松浩, 小松浩, 竹内光, 菊地淑恵, 小野千晶, 兪志前, 兪志前, 飯塚邦夫, 角藤芳久, 舩越俊一, 舩越俊一, 大野高志, 川島隆太, 川島隆太, 川島隆太, 瀧靖之, 瀧靖之, 瀧靖之, 富田博秋, 富田博秋, 富田博秋, 富田博秋

日本うつ病学会総会プログラム・抄録集　16th　2019
東京オリンピック・パラリンピック2020において救急医が果たす役割-MCI対応における課題爆風損傷臨床、診療体制、医療以外の連携

中川敦寛, アーマン・ダロッコ, ローゼンタール・ガイ, 富田博秋, 佐久間篤, 八木橋真央, マンレー・ジェフリー, 久志本成樹, 冨永悌二

日本救急医学会雑誌　29　(10)　379-379　2018/10
Publisher: (一社)日本救急医学会
ISSN： 0915-924X
東日本大震災後のメンタルヘルス関連指標変化と家屋被害の関連

土屋菜歩, 中村智洋, 平田匠, 成田暁, 小暮真奈, 丹野高三, 坂田清美, 小原拓, 中谷直樹, 栗山進一, 辻一郎, 呉繁夫, 大塚耕太郎, 富田博秋, 寳澤篤

日本公衆衛生学会総会抄録集　77回　252-252　2018/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
爆傷と銃創臨床、診療体制

中川敦寛, Armonda Rocco, Rosenthal Guy, 大谷清伸, 冨田博秋, 佐久間篤, 八木橋真央, Manley Geoffrey, 久志本成樹, 冨永悌二

Japanese Journal of Acute Care Surgery　8　(1)　44-44　2018/09
Publisher: 日本Acute Care Surgery学会
OLIG2遺伝子多型(rs1059004)と統合失調症との関連、白質統合性、安静時脳灌流量及び認知機能への影響の検討

小松浩, 竹内光, 菊地淑恵, 小野千晶, 角藤芳久, 舩越俊一, 大野高志, 山森秀長, 安田由華, 藤本美智子, 畦地裕統, 工藤紀子, 川島隆太, 橋本亮太, 瀧靖之, 富田博秋

精神神経学雑誌　(2018特別号)　S656-S656　2018/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
高次脳機能障害の評価と対応頭部外傷後の心理的評価と社会復帰支援精神科リエゾン・臨床心理士の視点から

八木橋真央, 佐久間篤, 中川敦寛, 古谷桂子, 久志本成樹, 冨永悌二, 富田博秋

日本脳神経外傷学会プログラム・抄録集　41回　52-52　2018/02
Publisher: (一社)日本脳神経外傷学会
宮城県における東日本大震災被災者の健康状態等に関する調査被災者の身体活動・要介護発生に関する検討

永富良一, 遠又靖丈, 辻一郎, 菅原由美, 関口拓矢, 丹治史也, 大塚達以, 富田博秋

宮城県における東日本大震災被災者の健康状態等に関する調査平成29年度総括・分担研究報告書(Web)　2018
東北大学病院総合診療外来における簡易心理検査の有用性と関連要因の検討

野崎裕之, 中川高, 阿部倫明, 八木橋真央, 甲賀ひとみ, 吉村直仁, 有田龍太郎, 齊藤奈津美, 田中淳一, 沼田健裕, 菅野武, 鈴木聡子, 大澤稔, 菊池章子, 黒田仁, 高山真, 奈良正之, 富田博秋, 石井正

総合病院精神医学　29　(Suppl.)　S-203　2017/11
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
精神医学のフロンティア東日本大震災後の子どもの心的外傷後成長と,法事参加・メディア視聴への態度との関連

吉田弘和, 小林奈津子, 本多奈美, 松岡洋夫, 山口拓洋, 本間博彰, 富田博秋

精神神経学雑誌　119　(11)　819-826　2017/11
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
IMPACT OF OLIG2 GENE VARIANT (RS1059004) ON WHITE MATTER TRACT INTEGRITY AND MEAN CEREBRAL BLOOD FLOW OF THE HUMAN BRAIN

Hiroshi Komatsu, Hikaru Takeuchi, Yoshie Kikuchi, Akira Kodaka, Shunichi Funakoshi, Takashi Ono, Yoshihisa Kakuto, Ryuta Kawashima, Yasuyuki Taki, Hiroaki Tomita

EUROPEAN NEUROPSYCHOPHARMACOLOGY　27　S315-S316　2017/10

ISSN： 0924-977X

eISSN： 1873-7862
ETHICAL ISSUES AND DATA PROTECTION WITHIN THE TOHOKU MEDICAL MEGABANK PROJECT

Fuji Nagami, Hiroaki Tomita

EUROPEAN NEUROPSYCHOPHARMACOLOGY　27　S122-S123　2017/10

ISSN： 0924-977X

eISSN： 1873-7862
性・年齢階級別にみた家族との同居状況と心理的苦痛の関連地域住民コホート調査

及川真紀, 佐藤喜根子, 佐藤眞理, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 富田博秋, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　76回　315-315　2017/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
社会復帰を目指す救急医療:長期予後を改善する頭部外傷クリニック体制、意義、サステナビリティ

中川敦寛, 冨田博秋, 古谷桂子, 佐久間篤, 工藤大介, ジェフリー・マンレー, 久志本成樹, 冨永悌二

日本救急医学会雑誌　28　(9)　431-431　2017/09
Publisher: (一社)日本救急医学会
ISSN： 0915-924X
東日本大震災被災コミュニティの就労状況と精神的健康に関する縦断的研究

片柳光昭, 瀬戸萌, 根本晴美, 菅原由美, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小高晃, 辻一郎, 寳澤篤, 富田博秋

日本社会精神医学会雑誌　26　(3)　240-241　2017/08
Publisher: (一社)日本社会精神医学会
ISSN： 0919-1372
東日本大震災被災者における不眠症と口腔愁訴との関連

土谷昌広, 相田潤, 萩原嘉廣, 菅原由美, 遠又靖丈, 佐藤眞理, 渡邉崇, 富田博秋, 根本英二, 渡邉誠, 小坂健, 小坂健, 辻一郎

Pain Research　32　(2)　125　2017/06/16

ISSN： 0915-8588
東日本大震災後の沿岸部と内陸部の慢性疾患の治療中断割合の比較

中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 富田博秋, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　27th　100 (WEB ONLY)　2017/01/25
東日本大震災後のメンタルヘルスの内陸‐沿岸較差:東北メディカル・メガバンク事業

成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 冨田博秋, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　27th　126 (WEB ONLY)　2017/01/25
東北大学病院総合診療外来新患におけるうつ度および認知度の実態調査

阿部倫明, 野崎裕之, 中川高, 八木橋真央, 有田龍太郎, 齊藤奈津美, 田中淳一, 沼田健裕, 菅野武, 宇佐美修, 大澤稔, 黒田仁, 高山真, 奈良正之, 富田博秋, 石井正

日本プライマリ・ケア連合学会学術大会抄録集　8th　2017
宮城県における東日本大震災被災者の健康状態等に関する調査被災者健康調査の実施と分析

辻一郎, 遠又靖丈, 菅原由美, 渡邉崇, 海法悠, 丹治史也, 大塚達以, 村上綾, 押谷仁, 神垣太郎, 松岡洋夫, 松本和紀, 八重樫伸生, 永富良一, 井樋栄二, 萩原嘉廣, 関口拓矢, 富田博秋, 佐々木啓一, 小坂健, 相田潤, 金村政輝, 粟田主一, 鈴木玲子, 曽根稔雅

宮城県における東日本大震災被災者の健康状態等に関する調査平成28年度総括・分担研究報告書(Web)　9‐14 (WEB ONLY)　2017
インターネットを使用した災害時の精神保健・心理社会的支援に関する研究

大滝涼子, 井筒節, 富田博秋, 堤敦朗, 大沼麻実, 種市康太郎, 宮本有紀, 中谷優, 金吉晴

国立精神・神経医療研究センター精神保健研究所年報　(29)　242-242　2016/10
Publisher: (国研)国立精神・神経医療研究センター精神保健研究所
東日本大震災における外傷と心理的苦痛の関連七ヶ浜健康増進プロジェクト

成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 辻一郎, 寳澤篤, 富田博秋

日本公衆衛生学会総会抄録集　75回　208-208　2016/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災後の身体活動量とこころの健康の関連地域住民コホート調査

中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 坂田清美, 富田博秋, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　75回　288-288　2016/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
沿岸部居住者における東日本大震災後の新規うつ病・PTSD罹患リスク

中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 坂田清美, 富田博秋, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　75回　303-303　2016/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
Psychological changes after trauma-related distress:Using a Great East Japan Earthquake video

Hironobu Kato, Chiaki Ono, Tomohiro Uchida, Hiroaki Tomita

INTERNATIONAL JOURNAL OF PSYCHOLOGY　51　962-962　2016/07

ISSN： 0020-7594

eISSN： 1464-066X
震災1年後の将来の住宅の見通しと心理的苦痛リスク

中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 辻一郎, 寳澤篤, 富田博秋

東北公衆衛生学会誌　(65)　14-14　2016/07
Publisher: 東北公衆衛生学会
ISSN： 0915-549X
Pregnant mice exposure to extreme level of oxytocin influences emotional and social behaviors of the offsprings after growing up

Yoshiyuki Kasahara, Sachie Suzuki, Yuji Onouchi, Ayaka Yoshida, Chiaki Ono, Yoshie Kikuchi, Zhiqian Yu, Hiroaki Tomita

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY　19　50-50　2016/06

ISSN： 1461-1457

eISSN： 1469-5111
Association between mu-opioid receptor gene variant 118 A > G and personality traits among Japanese population

Yumiko Kubo, Hikaru Takeuchi, Yoshie Kikuchi, Yoshiyuki Kasahara, Zhiqian Yu, Yasuyuki Taki, Ryuta Kawashima, Hiroaki Tomita

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY　19　299-300　2016/06

ISSN： 1461-1457

eISSN： 1469-5111
東日本大震災に被災した高校生に対する学校を基盤とした心理的介入

奥山純子, 舩越俊一, 本多奈美, 富田博秋, 大野高志, 小高晃, 井上貴雄, 傳田健三, 松岡洋夫

精神神経学雑誌　(2016特別号)　S519-S519　2016/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
【学校と精神医学II】臨床経験東日本大震災に被災した高校生の不登校について

奥山純子, 舩越俊一, 本多奈美, 富田博秋, 小高晃

精神科治療学　31　(5)　645-649　2016/05
Publisher: (株)星和書店
ISSN： 0912-1862
東日本大震災1年後の沿岸部被災地における心理的苦痛と高血圧治療中断の関連七ヶ浜健康増進プロジェクト

中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 辻一郎, 寳澤篤, 富田博秋

日本循環器病予防学会誌　51　(2)　134-134　2016/05
Publisher: (一社)日本循環器病予防学会
ISSN： 1346-6267
東日本大震災後の宮城県沿岸部における治療中断東北メディカル・メガバンク事業地域住民コホート調査

中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 中谷純, 峯岸直子, 布施昇男, 鈴木洋一, 菅原準一, 菊谷昌浩, 富田博秋, 清元秀泰, 栗山進一, 辻一郎, 呉繁夫, 山本雅之, 寳澤篤, 丹野高三, 佐々木亮平, 坂田清美

宮城県公衆衛生学会会誌　(48)　11-11　2016/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
東日本大震災後2年間の震災関連症状による児童精神科クリニックの受診患者に関する研究

吉田弘和, 水本有紀, 佐藤美和子, 小野寺滋実, 本多奈美, 富田博秋, 本間博彰

児童青年精神医学とその近接領域　57　(1)　195-204　2016/02
Publisher: (一社)日本児童青年精神医学会
ISSN： 0289-0968
東日本大震災後の心理的苦痛と新規要介護認定リスクとの関連

丹治史也, 菅原由美, 遠又靖丈, 渡邉崇, 杉山賢明, 本藏賢治, 海法悠, 富田博秋, 辻一郎, 辻一郎

Journal of Epidemiology (Web)　26　(Supplement 1)　72　2016/01/21

ISSN： 0917-5040
宮城県における東日本大震災被災者の健康状態等に関する調査被災者健康調査の実施

辻一郎, 遠又靖丈, 菅原由美, 渡邉崇, 杉山賢明, 本藏賢治, 海法悠, 丹治史也, 大塚達以, 村上綾, 押谷仁, 神垣太郎, 三村敬司, 松岡洋夫, 松本和紀, 八重樫伸生, 永富良一, 井樋栄二, 萩原嘉廣, 関口拓矢, 富田博秋, 南優子, 佐々木啓一, 小坂健, 相田潤, 金村政輝, 粟田主一, 鈴木玲子, 曽根稔雅

宮城県における東日本大震災被災者の健康状態等に関する調査平成27年度総括・分担研究報告書　9‐13　2016
宮城県における東日本大震災被災者の健康状態等に関する調査医療受療と介護保険認定に関する検討

南優子, 辻一郎, 菅原由美, 遠又靖丈, 渡邉崇, 杉山賢明, 本藏賢治, 海法悠, 丹治史也, 富田博秋

宮城県における東日本大震災被災者の健康状態等に関する調査平成27年度総括・分担研究報告書　62‐69　2016
宮城県における東日本大震災被災者の健康状態等に関する調査被災者における新規要介護認定のリスク要因

辻一郎, 丹治史也, 遠又靖丈, 菅原由美, 渡邉崇, 杉山賢明, 本藏賢治, 海法悠, 富田博秋

宮城県における東日本大震災被災者の健康状態等に関する調査平成27年度総括・分担研究報告書　81‐86　2016
東日本大震災後の宮城県における歯科受診状況と関連因子についての検討

土屋菜歩, 坪井明人, 白石成, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 鈴木洋一, 菊谷昌浩, 富田博秋, 栗山進一, 辻一郎, 呉繁夫, 山本雅之, 寳澤篤

日本公衆衛生学会総会抄録集　74回　261-261　2015/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
宮城県地域住民における心理的苦痛と喫煙行動の関連についての検討

成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 佐々木亮平, 坂田清美, 富田博秋, 栗山進一, 辻一郎, 呉繁夫, 山本雅之, 寳澤篤

日本公衆衛生学会総会抄録集　74回　296-296　2015/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災後の睡眠薬服用開始に関連する規定要因の検討地域住民コホート調査

中村智洋, 富田博秋, 中谷直樹, 土屋菜歩, 成田暁, 中谷純, 菊谷昌浩, 栗山進一, 辻一郎, 呉繁夫, 山本雅之, 寳澤篤, 丹野高三, 佐々木亮平, 坂田清美

日本公衆衛生学会総会抄録集　74回　296-296　2015/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
災害ストレス・トラウマの心身への影響 : 如何に備え,対応するか (第16回身体疾患と不安・抑うつ研究会)

富田博秋

分子精神医学　15　(3)　247-250　2015/07
Publisher: 先端医学社
ISSN： 1345-9082
東北メディカル・メガバンク地域住民コホート宮城エリアにおける随時尿Na/K比の内陸部・沿岸部比較

寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 佐々木亮平, 坂田清美, 中谷純, 峯岸直子, 清元秀泰, 菅原準一, 布施昇男, 菊谷昌浩, 鈴木洋一, 富田博秋, 栗山進一, 辻一郎, 呉繁夫, 八重樫伸生, 山本雅之

日本循環器病予防学会誌　50　(2)　126-126　2015/06
Publisher: (一社)日本循環器病予防学会
ISSN： 1346-6267
東日本大震災被災者の喪失と悲嘆のプロファイル

小林奈津子, 新宮古都美, 庄子朋香, 北田友子, 中谷直樹, 中村智洋, 土屋菜歩, 吉田弘和, 菊地紗耶, 本多奈美, 松岡洋夫, 中島聡美, 寳澤篤, 辻一郎, 富田博秋

日本精神神経学会総会プログラム・抄録集　111th　S.364　2015
東日本大震災での笑いの規定要因と精神的健康度の推測七ヶ浜健康増進プロジェクト

中村智洋, 中谷直樹, 土屋菜歩, 辻一郎, 寳澤篤, 富田博秋

日本公衆衛生学会総会抄録集　73回　239-239　2014/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災の被災地における慢性疾患治療と就労の関連七ヶ浜健康増進プロジェクト

中谷直樹, 中村智洋, 土屋菜歩, 辻一郎, 寳澤篤, 富田博秋

日本公衆衛生学会総会抄録集　73回　270-270　2014/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
ソーシャルキャピタルと健康状態との関連家屋の被災程度との交互作用の検討

土屋菜歩, 中谷直樹, 中村智洋, 辻一郎, 寳澤篤, 富田博秋

日本公衆衛生学会総会抄録集　73回　480-480　2014/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
各種災害関連ストレスが東日本大震災沿岸部被災者の精神的健康に及ぼす影響の検討

鈴木大輔, 中谷直樹, 中村智洋, 中島聡美, 金吉晴, 辻一郎, 寳澤篤, 富田博秋

日本社会精神医学会雑誌　23　(3)　259-259　2014/08
Publisher: (一社)日本社会精神医学会
ISSN： 0919-1372
東北メディカル・メガバンク事業―三世代コホート調査に関する経過報告

目時弘仁, 小原拓, 石黒真美, 成川洋子, 菊谷昌浩, 目時弘仁, 小原拓, 石黒真美, 成川洋子, 菊谷昌浩, 栗山進一, 栗山進一, 栗山進一, 中谷直樹, 寶澤篤, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 中谷直樹, 寶澤篤, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 富田博秋, 富田博秋, 富田博秋, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生

J Epidemiol　24　(Supplement 1)　67　2014/01/23

ISSN： 0917-5040
東北メディカル・メガバンク事業―地域住民コホート調査に関する経過報告

寶澤篤, 寶澤篤, 寶澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 菊谷昌浩, 目時弘仁, 小原拓, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 中谷直樹, 中村智洋, 土屋菜歩, 菊谷昌浩, 目時弘仁, 小原拓, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 富田博秋, 富田博秋, 富田博秋, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生, 山本雅之, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生, 山本雅之

J Epidemiol　24　(Supplement 1)　67　2014/01/23

ISSN： 0917-5040
宮城県における東日本大震災被災者の健康状態等に関する調査被災者健康調査の実施概要

辻一郎, 菅原由美, 遠又靖丈, 柿崎真沙子, 福地成, 周婉てい, 渡邉崇, 杉山賢明, 本蔵賢治, 海法悠, 小暮真奈, 伊藤久美子, 押谷仁, 神垣太郎, 三村敬司, 松岡洋夫, 松本和紀, 富田博秋, 八重樫伸生, 永富良一, 須藤彰子, 井樋栄二, 萩原嘉廣, 南優子, 佐々木啓一, 小坂健, 相田潤, 金村政輝, 粟田主一, 鈴木玲子

宮城県における東日本大震災被災者の健康状態等に関する調査平成25年度総括研究年度終了報告書　11-18　2014
次世代シークエンサーを駆使した希少遺伝性難病の原因解明と治療法開発の研究希少遺伝性難病の精神発達に関する病態解明のための網羅的分子遺伝学的研究

富田博秋, 福與なおみ, 小野千晶, 兪志前

次世代シークエンサーを駆使した希少遺伝性難病の原因解明と治療法開発の研究平成25年度総括・分担研究報告書　61-63　2014
次世代シークエンサーを駆使した希少遺伝性難病の原因解明と治療法開発の研究希少遺伝性難病の精神発達に関する病態解明のための網羅的分子遺伝学的研究

富田博秋, 福與なおみ, 小野千晶, 兪志前

次世代シークエンサーを駆使した希少遺伝性難病の原因解明と治療法開発の研究平成23-25年度総合研究報告書　69-73　2014
宮城県における東日本大震災被災者の健康状態等に関する調査被災者のメンタルヘルス支援と効果評価―東日本大震災被災者のメンタルヘルスの推移―

松岡洋夫, 菅原由美, 辻一郎, 遠又靖丈, 柿崎真沙子, 福地成, 周婉てい, 渡邉崇, 杉山賢明, 本蔵賢治, 海法悠, 小暮真奈, 富田博秋, 松本和紀, 粟田主一

宮城県における東日本大震災被災者の健康状態等に関する調査平成25年度総括研究年度終了報告書　32-40　2014
慢性疾患治療者における心理的苦痛に関する研究七ヶ浜健康増進プロジェクト

中谷直樹, 中村智洋, 辻一郎, 寳澤篤, 富田博秋

日本公衆衛生学会総会抄録集　72回　198-198　2013/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災における喫煙・飲酒の行動変化と規定要因七ヶ浜健康増進プロジェクト

中村智洋, 中谷直樹, 辻一郎, 寳澤篤, 富田博秋

日本公衆衛生学会総会抄録集　72回　198-198　2013/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災沿岸部被災者の精神的健康の変遷と現況

鈴木大輔, 築田美抄, 上田穫, 中谷直樹, 金吉晴, 辻一郎, 寶澤篤, 富田博秋

精神神経学雑誌　(2013特別)　S-568　2013/05
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
Identification of biomarkers for depression in postmortem brain research

244　(5)　496-501　2013/02/02
Publisher: 医歯薬出版
ISSN： 0039-2359
宮城県における東日本大震災被災者の健康状態等に関する調査東日本大震災被災者のメンタルヘルスの推移

松岡洋夫, 柿崎真沙子, 辻一郎, 中原篤史, 佐藤紀子, 高橋英子, 曽根稔雅, 福地成, 遠又靖丈, 菅原由美, 松尾兼幸, 周婉てい, 渡邉崇, 杉山賢明, 本蔵賢治, 小暮真奈, 押谷仁, 平野かよ子, 八重樫伸生, 永富良一, 井樋栄二, 南優子, 佐々木啓一, 小坂健, 富田博秋, 松本和紀, 粟田主一

宮城県における東日本大震災被災者の健康状態等に関する調査平成24年度総括・分担研究報告書　39-47　2013
FACS-arrayによる統合失調症罹患者のTh1およびTh2細胞の遺伝子発現プロファイリング

小野千晶, 兪志前, 小松浩, 小松浩, 石井直人, 曽良一郎, 富田博秋

統合失調症研究　2　(1)　2012
微量脳組織におけるpH測定とその組織内発現プロファイルへの影響～死後脳研究とブレインバンク運営に有用な方法論の検討～

小野千晶, 愈志前, 國井泰人, 和田明, 松本純弥, 日野瑞城, 池本桂子, 曽良一郎, 丹羽真一, 富田博秋

統合失調症研究　2　(1)　127　2012
東日本大震災被災者の健康状態等に関する調査宮城県調査

辻一郎, 佐藤眞理, 柿崎真沙子, 高橋英子, 永井雅人, 曽根稔雅, 福地成, 坪谷透, 遠又靖丈, 菅原由美, 松尾兼幸, 周婉てい, 渡邊崇, 星玲奈, 丹治史也, 平野かよ子, 押谷仁, 松岡洋夫, 八重樫伸生, 永富良一, 南優子, 佐々木啓一, 小坂健, 松本和紀, 富田博秋, 金村正輝, 相田潤, 粟田主一

東日本大震災被災者の健康状態等に関する調査平成23年度総括・分担研究報告書　209-219　2012
統合失調症の死後脳研究の現状と展望 (精神科治療学 )

富田博秋

精神科治療学　26　(12)　1581-1587　2011/12
統合失調症の陰性症状の進行に関わる精神神経免疫学的メカニズムに関する研究． (こころの健康と病気2010年版)

富田博秋, 小野千晶, 兪志前

こころの健康と病気2010年版　119-131　2011/11
ソトス症候群のスクリーニング・診断システムの確立に向けた実態調査

福與なおみ, 富田博秋, 岡本信彦, 黒澤健司, 松本直通, 黒滝直弘, 萩野谷和裕, 植松貢, 土屋滋

脳と発達　43　(Suppl.)　S370-S370　2011/05
Publisher: (一社)日本小児神経学会
ISSN： 0029-0831
ソトス症候群のスクリーニング・診断システムの確立に向けた実態調査

福與なおみ, 冨田博秋, 岡本伸彦, 黒澤健司, 松本直通, 萩野谷和裕, 植松貢, 土屋滋

日本小児科学会雑誌　115　(2)　427-427　2011/02
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
FACS-microarray study of immune cells from patients with schizophrenia

Chiaki Ono, Zhiqian Yu, Yoichiro Tanabe, Naoto Ishii, Hiroaki Tomita

NEUROSCIENCE RESEARCH　71　E366-E366　2011

DOI： 10.1016/j.neures.2011.07.1604 　

ISSN： 0168-0102
ソトス症候群の臨床症状の解析―ソトス症候群のスクリーニング・診断システム確立に向けて―

福與なおみ, 黒澤健司, 岡本伸彦, 松本直通, 黒滝直弘, 石川亜貴, 萩野谷和裕, 植松貢, 呉繁夫, 富田博秋

日本人類遺伝学会大会プログラム・抄録集　56th　195　2011
死後脳研究の展望と脳バンク (精神医学)

富田博秋

精神医学　52　(4)　367-376　2010/11

DOI： 10.11477/mf.1405101606 　
ソトス症候群罹患者リンパ芽球のマイクロアレイ解析~NSD1の下流で発現調節を受ける遺伝子群の検索~

富田博秋, 小野千晶, 兪志前, 田邊陽一郎, 福與なおみ, 西村章, 黒滝直弘, 黒澤健司, 岡本伸彦, 松本直通

日本人類遺伝学会大会プログラム・抄録集　55th　174　2010/10/08
ラモトリギン投与によるヒトニューロン由来SK-N-SH細胞における包括的遺伝子発現の検討(Examination of the comprehensive gene expression in the SK-N-SH cell by the LTG dosage)

田邊陽一郎, 愈志前, 小野千晶, 羽藤愛, 松岡洋夫, 曽良一郎, 富田博秋

日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集　20回・40回　124-124　2010/09
Publisher: 日本臨床精神神経薬理学会・日本神経精神薬理学会
気分安定薬のアストロサイトにおける軸索誘導タンパク発現の誘導 (日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集)

兪志前, 小野千晶, 田邊陽一郎, 小松浩, 松岡洋夫, 曽良一郎, 富田博秋

日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集　20回・40回　124-124　2010/09
Publisher: 日本臨床精神神経薬理学会・日本神経精神薬理学会
統合失調症罹患者のTh1およびTh2細胞のマイクロアレイ遺伝子発現プロファイリング (日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集)

小野千晶, 兪志前, 田邊陽一郎, 小松浩, 松岡洋夫, 曽良一郎, 石井直人, 富田博秋

日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集　20回・40回　151-151　2010/09
Publisher: 日本臨床精神神経薬理学会・日本神経精神薬理学会
双極性障害治療薬のアストロサイトにおける遺伝子発現変化の包括的検討(Mood stabilizers-mediated gene expression in human astrocytes)

兪志前, 小野千晶, 田邊陽一郎, 曽良一郎, 富田博秋

神経化学　49　(2-3)　676-676　2010/08
Publisher: 日本神経化学会
ISSN： 0037-3796
Bardet-Biedl症候群．肥満―最新の基礎・臨床研究― (日本臨牀)

富田博秋

日本臨牀　67　(2)　506-510　2010/04
Molecular mechanisms of obesity and Bardet-Biedl syndrome

Japanese journal of clinical medicine　68　506-510　2010/02
Publisher: 日本臨床社
ISSN： 0047-1852
Effect of chronic lithium treatment on gene expression profile in mouse microglia and brain dendritic cells

Z. Yu, C. Ono, Y. Tanabe, I. Sora, H. Tomita

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY　13　133-134　2010

ISSN： 1461-1457
Comprehensive gene expression analysis of SK-N-SH cells after Lamotrigine treatment

Yoichiro Tanabe, Zhiqian Yu, Chiaki Ono, Ai Hato, Hiroo Matsuoka, Hiroaki Tomita

NEUROSCIENCE RESEARCH　68　E317-E317　2010

DOI： 10.1016/j.neures.2010.07.1409 　

ISSN： 0168-0102
Mood stabilizers-mediated gene expression in human astrocytes

Zhiqian Yu, Chiaki Ono, Yoichiro Tanabe, Ichiro Sora, Hiroaki Tomita

NEUROSCIENCE RESEARCH　68　E317-E317　2010

DOI： 10.1016/j.neures.2010.07.1407 　

ISSN： 0168-0102
死後脳研究の現在と今後．精神医学Update―最新研究動向 (医学のあゆみ)

富田博秋

医学のあゆみ　231　(10)　967-973　2009/12/05
Publisher: 医歯薬出版
ISSN： 0039-2359
交絡因子に配慮した脳バンク構築の必要性 (脳と精神の医学)

富田博秋, 田中千晶, 兪志前

脳と精神の医学　20　(1)　17-24　2009/07

DOI： 10.11249/jsbp.20.17 　
AD/HDの遺伝要因解明の現状 (分子精神医学)

曽良一郎, 笠原好之, 内海修, 久保有美子, 富田博秋, 池田和隆

分子精神医学　9　(3)　262-267　2009/07
Comprehensive gene expression analysis into mood disorder

229　(3)　182-186　2009/04/18
Publisher: 医歯薬出版
ISSN： 0039-2359
気分障害の網羅的遺伝子発現解析 (医学のあゆみ)

富田博秋

医学のあゆみ　229　(3)　8121-8125　2009/04
気分安定薬のアストロサイトにおける遺伝子発現変化の包括的検討

兪志前, 田中千晶, 小松浩, 高橋怜史, 木村好, 曽良一郎, 富田博秋

日本生物学的精神医学会プログラム・講演抄録　31st　2009
気分安定薬リチウムの樹状細胞における遺伝子発現変化の包括的検討

兪志前, 小野千晶, 田邊陽一郎, 田邊陽一郎, 小松浩, 小松浩, 木村好, 羽藤愛, 松岡洋夫, 曽良一郎, 富田博秋

日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集　19th-39th　2009
ラモトリギン投与によるヒト脳由来細胞における包括的遺伝子発現の解析

田邊陽一郎, 田邊陽一郎, 田邊陽一郎, 田中千晶, 愈志前, 小松浩, 小松浩, 木村好, 羽藤愛, 松岡洋夫, 曽良一郎, 富田博秋

日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集　19th-39th　2009
精神医学と倫理(第8回)精神科ブレインバンク構築のための倫理的基盤

富田博秋

分子精神医学　8　(4)　353-356　2008/10
Publisher: 先端医学社
ISSN： 1345-9082
精神科ブレインバンク構築のための倫理的基盤 (分子精神医学)

富田博秋

分子精神医学　8　(4)　69-72　2008/08
精神疾患研究におけるミトコンドリア関連遺伝子の発現変化〜病態か、アーチファクトか？ (脳と精神の医学)

富田博秋, 田中千晶

脳と精神の医学　19　(2)　97-106　2008/07
気分調整薬がヒト神経由来細胞およびグリア由来細胞の各BDNF転写物バリアント発現量に及ぼす影響の検討

小松浩, 田中千晶, 兪志前, 木村好, 高橋さとし, 曽良一郎, 松岡洋夫, 富田博秋

日本生物学的精神医学会プログラム・講演抄録　30th　2008
Lithium-induced gene expression profiles in neuronal and glial cell lines

Hiroaki Tomita, Chiaki Tanaka, Helen B. Kim, William E. Bunney

NEUROSCIENCE RESEARCH　61　S207-S207　2008

ISSN： 0168-0102
精神疾患研究におけるミトコンドリア関連遺伝子の発現変化〜病態か、アーチファクトか？ (脳と精神の医学)

富田博秋, 田中千晶

脳と精神の医学　19　(2)　97-106　2008/01
Bipolar Disorder candidate gene custom SNP panel: Design and preliminary results

Margit Burmeister, Laura J. Scott, Yun Li, Robert C. Thompson, Jun Li, Fan Meng, Weihua Guan, Devin Absher, Marquis P. Vawter, Prabhakara Choudary, Hiroaki Tomita, Simon J. Evans, William E. Bunney, Edward G. Jones, Jack D. Barchas, Alan F. Schatzberg, Huda Akil, Stanley J. Watson, Richard M. Myers, Michael Boehnke

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS　141B　(7)　695-695　2006/10

ISSN： 1552-4841
精神医療に役立つDNA-RNA-蛋白-細胞-組織-臨床症状のリンク情報を求めて (分子精神医学)

富田博秋

分子精神医学　6　(4)　1　2006/10
死後脳組織を使った分子遺伝学的研究の実際 (分子精神医学)

富田博秋

分子精神医学　6　(3)　243-250　2006/07
Publisher: 先端医学社
ISSN： 1345-9082
Mitochondrial related gene expression in suicide

MP Vawter, SJ Evans, PV Choudary, F Meng, ME Atz, P Cartagena, DM Walsh, J Li, H Tomita, RM Myers, H Akil, SJ Watson, EG Jones, WE Bunney

NEUROPSYCHOPHARMACOLOGY　30　S243-S243　2005/12

ISSN： 0893-133X
Gene expression profile of G protein coupled receptor and related signaling pathways in mood disorder

H Tomita, SJ Evans, JZ Li, PV Choudary, MP Vawter, F Meng, H Kim, CR Neal, DM Walsh, ME Atz, L Shao, RM Myers, EG Jones, SJ Watson, H Akil, WE Bunney

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS　138B　(1)　4-5　2005/09

ISSN： 1552-4841
Mitochondrial related gene expression in affective disorders in postmortem brain: An epiphenomenon?

MP Vawter, ME Atz, F Meng, H Tomita, BM Bolstad, JZ Li, L Shao, TE Speed, P Choudary, C Neal, J Stead, S Flagel, S Evans, K Overman, DM Walsh, R Myers, SJ Watson, EG Jones, H Akil, WE Bunney

NEUROPSYCHOPHARMACOLOGY　29　S214-S214　2004/12

ISSN： 0893-133X
Bipolar disorder: A discovery process utilizing microarray technology

WE Bunney, EG Jones, MP Vawter, H Tomita, J Li, SJ Evans, BG Bunney, PV Choudary, RM Myers, SJ Watson, H Akil

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY　7　S79-S79　2004/06

ISSN： 1461-1457
RNA expression studies in major depression

SJ Watson, SJ Evans, MP Vawter, PV Choudary, J Li, H Tomita, RM Myers, EG Jones, WE Bunney, H Akil

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY　7　S79-S79　2004/06

ISSN： 1461-1457
LRP5, low density lipoprotein-receptor-related protein 5, is a bone-mineral-density determinant.

T Mizuguchi, Y Watanabe, K Tsukamoto, H Tomita, N Niikawa, K Yoshiura

AMERICAN JOURNAL OF HUMAN GENETICS　73　(5)　389-389　2003/11

ISSN： 0002-9297
A scyllatoxin-insensitive isoform of the human SK3 channel

OH Wittekindt, Visan, V, H Tomita, F Imtiaz, JJ Gargus, F Lehmann-Horn, S Grissmer, DJ Morris-Rosendahl

AMERICAN JOURNAL OF HUMAN GENETICS　73　(5)　514-514　2003/11

ISSN： 0002-9297
Effects of mood disorders and suicide on gene expression profiles in postmortem brains

H Tomita, MP Vawter, SJ Evans, P Choudary, J Li, B Bolstad, T Speed, RM Myers, EG Jones, S Watson, H Akil, WE Bunney

AMERICAN JOURNAL OF HUMAN GENETICS　73　(5)　518-518　2003/11

ISSN： 0002-9297
Patterns of differential gene expression in schizophrenia overlap InCortical regions

MP Vawter, SJ Evans, P Choudary, M Atz, H Tomita, B Bolstad, J Li, T Speed, R Myers, SJ Watson, EG Jones, H Akil, WE Bunney

AMERICAN JOURNAL OF HUMAN GENETICS　73　(5)　518-518　2003/11

ISSN： 0002-9297
Anterior cingulate gene expression differences found in bipolar disorder by oligonucleotide microarray analysis

MP Vawter, H Tomita, S Evans, P Choudary, J Li, JH Meador-Woodruff, R Myers, EG Jones, SJ Watson, H Akil, WE Bunney

BIOLOGICAL PSYCHIATRY　53　(8)　12S-13S　2003/04

ISSN： 0006-3223
Microarray studies in mood disorders: Distinct patterns seen between major depression and bipolar disorder in two frontal cortical regions

H Akil, S Evans, P Choudary, MP Vawter, H Tomita, J Li, JH Meador-Woodruff, JF Lopez, F Meng, R Myers, WE Bunney, EG Jones, SJ Watson

BIOLOGICAL PSYCHIATRY　53　(8)　12S-12S　2003/04

ISSN： 0006-3223
Naturally occurring dominant-negative SK3 channel isoform (vol 8, pg 460, 2003)

H Tomita, VG Shakkottai, GA Gutman, G Sun, WE Bunney, MD Cahalan, KG Chandy, JJ Gargus

MOLECULAR PSYCHIATRY　8　(8)　766-766　2003

DOI： 10.1038/sj.mp.4001407 　

ISSN： 1359-4184
Quantitative RT-PCR analysis of expression alterations in selective brain regions of patients with mood disorders.

J Li, PV Choudary, SJ Evans, MP Vawter, H Tomita, JM Woodruff, EG Jones, W Bunney, SJ Watson, H Akil, RM Myers

AMERICAN JOURNAL OF HUMAN GENETICS　71　(4)　489-489　2002/10

ISSN： 0002-9297
Camurati-Engelmann病の原因遺伝子の単離

木下晃, 斉藤隆, 蒔田芳男, 富田博秋, Ghadami Mohsen, 山田浩樹, 池川志郎, 福島義光, Murray Jeffrey C, 谷口直之

日本整形外科学会雑誌　75　(9)　480-480　2001/09
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
Domain-specific mutations in the human transforming growth factor beta 1 gene (TGFB1) result in Camurati-Engelmann disease.

A Kinoshita, T Saito, M Ghadami, H Tomita, Y Makita, K Yamada, S Ikegawa, G Nishimura, Y Fukushima, JC Murray, N Taniguchi, N Niikawa, K Yoshiura

AMERICAN JOURNAL OF HUMAN GENETICS　67　(4)　370-370　2000/10

ISSN： 0002-9297
A 1.5-Mb PAC/BAC Contig Spanning the Prader-Willi Syndorome Critical Region (PWCR)

Kondo Shinji, Tomita Hiro-Aki, Kishino Tatsuya, Yoshiura Koh-ichiro, Yamada Koki, Soeda Eiichi, Matsumoto Naomichi, Ohta Tohru, Fujii Tohru, Niikawa Norio

Acta medica Nagasakiensia　45　(1)　43-46　2000/06
Publisher: Nagasaki University
ISSN： 0001-6055
A locus for an autosomal dominant posterior polar cataract on chromosome 20.

K Yamada, H Tomita, K Yoshiura, S Kondo, K Wakui, Y Fukushima, S Ikegawa, Y Nakamura, T Amemiya, N Niikawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　41　(4)　S2-S2　2000/03

ISSN： 0146-0404
A gene responsible for paroxysmal kinesigenic choreoathetosis mapped to chromosome 16p11.2-g12.1.

H Tomita, K Yamada, N Niikawa, Y Nakane, S Nagamitsu, T Matsuishi, K Wakui, Y Fukushima, N Kato

AMERICAN JOURNAL OF HUMAN GENETICS　65　(4)　A449-A449　1999/10

ISSN： 0002-9297
2チャンネル筋電図フィードバックによる痙性斜頸の1治験例 : コンピュータ・グラフィクスを用いた試み : 第13回日本心身医学会中国・四国地方会演題抄録

長田昌士, 好永順二, 佐々木高伸, 井手下久登, 村岡満太郎, 富田博秋, 志和資朗, 引地明義

心身医学　31　(2)　165-166　1991/02/01
Publisher: 日本心身医学会
DOI： 10.15064/jjpm.31.2_165_4 　

ISSN： 0385-0307
The molecular biology of dopamine receptors

Y. Fujiwara, I. Sora, H. Tomita

Japanese Journal of Psychopharmacology　11　(3)　187-196　1991

ISSN： 0285-5313
II-B-49 連続監視課題を用いたうつ病患者のCNV : うつ病の治癒過程における変化を中心に(うつ病・うつ状態)

山中祐介, 好永順二, 佐々木高伸, 井手下久登, 小田尊之, 佐伯俊成, 長田昌士, 重川玲子, 菊本修, 村岡満太郎, 富田博秋, 志和資朗, 引地明義

心身医学　30　119-119　1990/05/01
Publisher: 日本心身医学会
DOI： 10.15064/jjpm.30.Abs_119_1 　

ISSN： 0385-0307

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Books and Other Publications 6

スマートテキスタイルの開発と応用

富田博秋

シーエムシー出版　2019/07
指定難病ペディア2019 (日本医師会生涯教育シリーズ)

富田博秋

日本医師会発行/診断と治療社発売　2019/07
東日本大震災合同調査報告土木編6

富田博秋, 根本晴美

（公社）土木学会　2017/03

ISBN: 9784810608663
災害精神医学

フレデリック・J, スタッダードJr, アナンド・パーンディヤ、クレイグ・L, カッツ(編著, 富田博秋, 高橋祥友, 丹羽真一

星和書店　2015/01

ISBN: 9784791108930
国際比較調査報告書2011年版

独立行政法人科学技術振興機構研究開発戦略センター, ed. 富田博秋

独立行政法人科学技術振興機構　2011/11
脳バンク精神疾患の謎を解くために

加藤忠史, 富田博秋

光文社新書　2011/11

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Presentations 131

個別化精神医療の展望～精神科領域でもそこまで来ている明日の医療技術～

富田博秋

第82回宮崎県精神科医会懇話会　2019/12/07
精神科医は如何に災害に備えるべきか～本邦の現状と展望～

富田博秋

第32回日本総合病院精神医学会総会　2019/11/16
精神疾患の個別化医療実現に向けて

富田博秋

東名古屋メンタルカンファランス学術講演会　2019/11/09
精神科領域の災害後急性期対応の課題と展望〜東日本大震災以降の災害の教訓を踏まえて〜

富田博秋

第27回精神科救急学会学術総会　2019/10/18
災害時に産業保健スタッフが知っておくべき精神保健 Invited

富田博秋

第29回日本産業衛生学会全国協議会　2019/09/12
生物・心理・社会学的側面を統合した幅広い視野からの児童青年精神医学を目指して～東北メディカル・メガバンク事業・未来型医療創成センターの取り組みを如何に児童精神医学領域の発展に活かし得るか～

富田博秋

第21回東北児童青年精神医学会　2019/07/07
母子メンタルヘルスへの脳科学からのアプローチ

富田博秋

2019年度年輪の会講演会　2019/06/30
東日本大震災と熊本地震の教訓に基づく精神科病院の災害対策の改善点

富田博秋

第115回日本精神神経学会学術総会　2019/06/21
東日本大震災からの心の復興と新時代の精神医療の確立を目指して～岩手と宮城の連携を考える～

富田博秋

岩手県精神科医会　2019/06/14
精神疾患の病態解明と個別化精神医療の実現を目指して

富田博秋

第104回東北医学会総会教授就任記念講演会　2019/06/03
栄養・生活習慣・炎症に着目したうつ病の発症要因解明と個別化医療技術開発

富田博秋

日本医療研究開発機構 2019年度融合脳うつ病・双極性障害等の克服研究チーム分科会　2019/05/31
心を健康に保つコツ

富田博秋

河北新報社主催「健康の医学教室」　2019/03/26
栄養・生活習慣・炎症に着目したうつ病の発症要因解明と個別化医療技術開発

富田博秋

平成30年度脳とこころの研究第四回公開シンポジウム「脳とこころの発達と成長」　2019/03/02
心的外傷後ストレス反応・抑うつに関わるミクログリアのサイトカイン産生と関連薬剤 Invited

富田博秋

第28回日本臨床精神神経薬理学会・第48回日本神経精神薬理学会合同年会　2018/11/15
精神疾患の多因子性への挑戦. 最新の脳科学研究で見えて来た精神疾患の治療・診断法-III Invited

富田博秋

2018年度年輪の会講演会　2018/07/08
研究体制整備が望まれる一方特殊な倫理的配慮が必要な研究領域～死後脳研究と災害医学研究の倫理～．委員会シンポジウム 25 精神医学研究の倫理～症例報告から大規模データ研究まで Invited

富田博秋

第114回日本精神神経学会学術総会　2018/06/23
医学研究を計画する段階での倫理的な配慮〜研究計画の立て方、研究対象者への説明と同意の取り方など〜ワークショップ 2 精神医学研究の発表における倫理と利益相反－精神神経学会機関誌への投稿を中心に－ Invited

富田博秋

第114回日本精神神経学会学術総会　2018/06/21
災害精神医学と未来型精神医療の確立 Invited

富田博秋

東北大学門戸開放　2018/05/14
七ヶ浜町役場メンタルヘルス研修 Invited

富田博秋

七ヶ浜町役場メンタルヘルス研修　2018/03/27
東日本大震災から7年を経て健やかに暮らすために Invited

富田博秋

お話しサロンだんだん（談・暖）　2018/03/06
東日本大震災から7年を経て健やかに暮らすために Invited

富田博秋

お話しサロンだんだん（談・暖）　2018/02/27
東日本大震災から7年を経て健やかに暮らすために Invited

富田博秋

お話しサロンだんだん（談・暖）　2018/02/20
災害精神医学研究・未来型精神医療に向けた研究 Invited

富田博秋

第20回evidence-based-psychiatry研修会　2018/02/15
東日本大震災から7年を経て健やかに暮らすために Invited

富田博秋

お話しサロンだんだん（談・暖）　2018/02/06
東日本大震災から7年を経て健やかに暮らすために Invited

富田博秋

お話しサロンだんだん（談・暖）　2018/01/30
東日本大震災から7年を経て健やかに暮らすために Invited

富田博秋

お話しサロンだんだん（談・暖）　2018/01/23
依存への対応～新たな流れ～ Invited

富田博秋

第19回evidence-based-psychiatry研修会　2017/12/28
Establishment of evidence-based disaster psychiatry to disseminate more effective disaster mental health response and preparedness. Symposium ”Perspectives in Evidence-based Mental Health Disaster Response and Preparedness～Towards Effective International International-presentation Invited

Hiroaki Tomita

The 1st World Bosai Forum　2017/11/27
Psychological changes due to watching earthquake-related videos International-presentation

Kato H, Ono C, Uchida T, Tomita H

International Conference on Education, Psychology, and Learning　2017/11/08
大災害とメンタルヘルス～一般診療医が備えるべきこと～

富田博秋

富士市医師会学術講演会　2017/11/01
うつ病病態に関わる遺伝子×環境相互作用の解明 Invited

富田博秋

医療心理懇話会第2回集会　2017/10/25
指定国立大学としての災害医学・精神医学への取り組み Invited

富田博秋

第18回evidence-based-psychiatry研修会　2017/10/19
今後のより有効な災害精神保健対応の体制づくりに向けた展望と課題～災害科学の役割～

富田博秋

第9回災害精神医学セミナー「こころの健康を考える熊本・宮城連携フォーラム～熊本地震から１年、東日本大震災から６年を振り返って～」　2017/10/17
うつ病研究と今後の精神医療の展望 Invited

富田博秋

第29回仙台精神科セミナー　2017/10/13
エビデンスに基づく災害精神医学の樹立に向けて～過去の大災害の教訓を活かして精神科医は如何に災害に備えるべきか～

富田博秋

第 6回日本精神科医学会学術大会　2017/10/12
うつ病患者の睡眠障害とその対応 Invited

富田博秋

EGUIDEプロジェクトうつ病薬物治療ガイドライン講習会　2017/10/08
その他の臨床的諸問題 Invited

富田博秋

EGUIDEプロジェクト統合失調症薬物治療ガイドライン講習会　2017/10/07
Lessons in post-disaster mental health issues - Longitudinal alterations of mental health conditions among communities affected by the Great East Japan Earthquake - International-presentation

Sato A, Tomita H

French-Japanese Week in Tokyo & Sendai.　2017/10/03
Posttraumatic stress reactions among communities affected by the Great East Japan Earthquake and investigations into the pathogeneses of PTSD. Symposium “Perspectives in PTSD research -6 years after the Great East Japan Earthquake- Invited

富田博秋

第60回日本神経化学会大会　2017/09/09
Psychological impact of the Great East Japan Earthquake –How sience can contribute to the recovery- International-presentation Invited

Hiroaki Tomita

the International Society of Neurochemistry –the Asian-Pacific Society for Neurochemistry-the Japanese Society for Neurochemistry (ISN-APSN-JSN) Joint Advanced School of Neurochemistry　2017/09/03
脳の形と遺伝子の多様性～精神疾患の解明に向けて～ Invited

富田博秋

017年度年輪の会講演会「最新の脳科学研究で見えて来た精神疾患の治療・診断法-Ⅱ」～精神疾患ブレインバンクの最新研究～　2017/06/18
栄養・生活習慣・炎症に着目したうつ病の発症要因解明と個別化医療技術開発の新展開

富田博秋

第17回evidence-based-psychiatry研修会　2017/06/15
東日本大震災とメンタルヘルスの諸問題~医学は如何に被災コミュニティに貢献し得るか~ Invited

富田博秋

熊本大学名医に聴く　2017/05/31
プライマリ・ケア医に向けた気分障害・不安障害診療のポイント Invited

富田博秋

東北大学『コンダクター型総合診療医』養成プログラムインテンシブコース2017年第2回メンタルヘルスサポートゼミ(主催：東北大学「コンダクター型総合診療医」養成プログラム)　2017/04/26
産後うつ対策の進展と研究の展望～臨床と制度策定・診療技術の向上と研究～ Invited

富田博秋

第16回evidence-based-psychiatry研修会　2017/04/20
災害から命と健康を守るための学際研究 Invited

富田博秋

東日本大震災6 周年シンポジウム　2017/03/12
How to deal with Disaster Mental Health Issues - Basics and Lessens from the Great East Japan Earthquake - International-presentation Invited

Hiroaki Tomita

Japan International Cooperation Agency (JICA) Thai C/P training for the Project on Strengthening the ASEAN Regional Capacity on Disaster Health Management (ARCH Project)　2017/03/03
災害メンタルヘルス最近の動向と今後の展望 Invited

富田博秋

第47回多摩田園臨床精神医学研究会　2017/01/20
東日本大震災からのこころの復興とこころの防災～5年半を経た被災地の現状と展望～ Invited

富田博秋

第5回日本精神科医学会学術大会　2016/11/16
災害後中長期のメンタルヘルス支援～東日本大震災後５年半の経験から～ Invited

富田博秋

熊本地震こころの支援者応援シリーズ講演会　2016/10/19
大規模災害と精神医学 Invited

富田博秋

50回日本てんかん学会学術集会　2016/10/07
災害被災者のメンタルヘルス～一般診療科医師の役割の重要性～ Invited

富田博秋

豊川内科医会学術講演会　2016/08/19
メンタルヘルスと脳科学 Invited

富田博秋

東北大学医学部オープンキャンパス2016．世界脳週間2016行事　2016/07/27
心的外傷後ストレス障害病態形成における炎症性メカニズムの解明

富田博秋

第46回日本神経精神薬理学会年会　2016/07/02
ストレスと脳内の微小な炎症～精神疾患病態改善法の開発に向けて～ Invited

富田博秋

2016年度年輪の会講演会　2016/06/19
東日本大震災から５年こころの復興、こころの防災の現在と未来 Invited

富田博秋

第15回日本トラウマティック・ストレス学会　2016/05/20
災害精神医学と被災地精神保健の現況と展望 Invited

富田博秋

第11回日本トラウマティック・ストレス学会　2012/06/10
Identification of novel transcription factors for catecholamine gene expression based upon the comprehensive analyses of transcripts in fetal pontine noradrenergic neurons by FACS-array technology. International-presentation

Itoi K, Uchida K, Fuse T, Iwasaki Y, Yokohashi H, Okazaki A, Sawada K, Das G, Kobayashi K, Tomita H, Tanaka C, Kinoshita K, Ohara S

Society for Neuroscience 38th annual meeting　2011/11/12
本邦におけるソトス症候群の臨床像の検討-ソトス症候群のスクリーニング・診断システム確立にむけて

福與なおみ, 黒澤健司, 岡本伸彦, 松本直通, 黒滝直弘, 石川亜貴, 萩野谷和裕, 土屋滋, 呉繁夫, 富田博秋

日本人類遺伝学会第56回大会　2011/11/11
Neuroethical perspectives in psychiatric brain banking

Tomita H

Neuro2011　2011/09/15
FACS-microarray study of immune cell from patients with schizophrenia

Chiaki Ono, Zhiqian Yu, Yoichiro Tanabe, Naoto Ishii, Hiroaki Tomita

Neuro2011 （第34回日本神経科学大会　2011/09/15
Effect of Chronic Lithium Treatment on Gene Expression Profile in Mouse Microglia and Brain Dendritic Cells

Zhiqian Yu, Chiaki Ono, Yoichiro Tanabe, Ichiro Sora, Hiroaki Tomita

Neuro2011 （第34回日本神経科学大会）　2011/09/15
ソトス症候群のスクリーニング・診断システム確立にむけた実態調査

福與なおみ, 富田博秋, 岡本伸彦, 黒澤健司, 松本直通, 黒滝直弘, 石川亜貴, 萩野谷和裕, 植松貢, 土屋滋, 呉繁夫

第114回日本小児科学会学術集会　2011/08/12
統合失調症理患者のTh1およびTh2細胞のマイクロアレイ遺伝子プロファイリング

小野千晶, 兪志前, 小松浩, 曽良一郎, 松岡洋夫, 石井直人, 富田博秋

第6回統合失調症学会　2011/07/18
脳内ミクログリアと末梢単球の遺伝子発現の相関解析〜統合失調症のミクログリア活性化を介した病態解明に向けた研究手法の開発〜

兪志前, 小野千晶, 富田博秋

第6回統合失調症学会　2011/07/18
ソトス症候群のスクリーニング・診断システムの確立に向けた実態調査．

福與なおみ, 富田博秋, 岡本信彦, 黒澤健司, 松本直道, 黒滝直弘, 萩野谷和裕, 植松貢, 土屋滋

第53回日本小児神経学会総会　2011/05/26
Four mood stabilizers commonly induce FEZ1 expression in human astrocytes

Zhiqian Yu, Chiaki Ono, Helen B Kim, Hiroshi Komatsu, Yoichiro Tanabe, Nobutaka Sakae, Keiichi I Nakayama, Hiroo Matsuoka, Ichiro Sora, William E Bunney, Hiroaki Tomita

第33回日本生物学的精神医学会　2011/05/20
統合失調症リスク遺伝子ZNF804Aの新規mRNA variantの検討

岡田武也, 橋本亮太, 山森英長, 梅田知美, 安田由華, 大井一高, 福本素由己, 富田博秋, 武田雅俊

第33回日本生物学的精神医学会　2011/05/20
双極性障害治療薬のアストロサイトにおける発現プロファイルへの影響

兪志前, 小野千晶, 田邊陽一郎, 小松浩, 松岡洋夫, 曽良一郎, 富田博秋

第9回Bipolar Disorder研究会　2010/11/20
ソトス症候群罹患者リンパ芽球のマイクロアレイ解析〜NSD1の下流で発現調節を受ける遺伝子群の探索〜

富田博秋, 小野千晶, 兪志前, 福與なおみ, 西村章, 黒滝直弘, 黒澤健司, 岡本伸彦, 松本直通

日本人類遺伝学会第55回大会　2010/10/30
本邦におけるソトス症候群の診断の実態調査

福與なおみ, 岡本信彦, 黒澤健司, 松本直道, 萩野谷和裕, 植松貢, 土屋滋, 富田博秋

日本人類遺伝学会第55回大会　2010/10/30
リチウムの樹状細胞を介した奏功機序解明のためのトランスクリプトーム研究

兪志前, 小野千晶, 田邊陽一郎, 小松浩, 松岡洋夫, 曽良一郎, 富田博秋

第18回日本精神行動遺伝医学会　2010/09/18
統合失調症罹患者のTh1およびTh2細胞のマイクロアレイ遺伝子発現プロファイリング

田中千晶, 兪志前, 田邊陽一郎, 小松浩, 松岡洋夫, 曽良一郎, 石井直人, 富田博秋

第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会　2010/09/17
ラモトリギン投与によるヒトニューロン由来SK-N-SH細胞における包括的遺伝子発現の検討

田邊陽一郎, 兪志前, 小野千晶, 羽藤愛, 松岡洋夫, 曽良一郎, 富田博秋

第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会　2010/09/15
精神疾患の薬剤開発に向けた機能ゲノムアプローチの展望

富田博秋

第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会　2010/09/15
気分安定薬のアストロサイトにおける軸索誘導タンパク発現の誘導

兪志前, 小野千晶, 田邊陽一郎, 小松浩, 松岡洋夫, 曽良一郎, 富田博秋

第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会　2010/09/15
Remaining tasks and new strategies in postmortem brain studies of psychiatric disorders

Tomita H

Neuro2010　2010/09/03
SK-N-SH細胞におけるラモトリギン投与後の包括的遺伝子発現解析

田邊陽一郎, 兪志前, 小野千晶, 羽藤愛, 松岡洋夫, 富田博秋

日本神経科学会Neuro2010　2010/09/03
双極性障害治療薬のアストロサイトにおける遺伝子発現変化の包括的検討

兪志前, 小野千晶, 田邊陽一郎, 曽良一郎, 富田博秋

日本神経科学会Neuro2010　2010/09/03
Effect of chronic lithium treatment on gene expression profiles in mouse monocyte, microglia and brain dendritic cells International-presentation

Yu Z, Ono C, Tanabe Y, Sora I, Tomita H

14th International Congress of Immunology (ICI 2010)　2010/08/22
FACS-microarray study of Th1/Th2 helper T cells from patients with schizophrenia International-presentation

Ono C, Yu Z, Tanabe Y, Ishii N, Tomita H

14th International Congress of Immunology (ICI 2010)　2010/08/22
Mechanism of mood stabilizing action of Lamotrigene - comprehensive gene expression analysis of neuronal cells-

Tanabe Y, Yu Z, Ono C, Hato A, Sora I, Matsuoka H, Tomita H

平成 22 年度「包括脳ネットワーク」夏のワークショップ　2010/07/28
Comprehensive gene expression analysis of SK-N-SH cells after Lamotrigine treatment International-presentation

Tanabe Y, Yu Z, Ono C, Hato A, Sora I, Matsuoka H, Tomita H

Collegium internationale neuro-psychopharmacologicum 51th congress　2010/06/06
Effect of chronic lithium treatment on gene expression profiles in mouse microglia and brain dendritic cells International-presentation

Yu Z, Ono C, Tanabe Y, Sora I, Tomita H

Collegium internationale neuro-psychopharmacologicum 51th congress　2010/06/06
Gene expression profiling of Th1/Th2 helper T cells from patients with schizophrenia International-presentation

Ono C, Yu Z, Tanabe Y, Matsuoka H, Ishii N, Tomita H

Collegium internationale neuro-psychopharmacologicum 51th congress　2010/06/06
People’s View on Life and Death and Development of Brain Bank in Japan

Tomita H

17th Annual Meeting of Japanese Society of Transcultural Psychiatry　2010/03/19
ソトス症候群責任遺伝子NSD1遺伝子の下流で発現調節を受ける遺伝子群のスクリーニング

富田博秋, 小野千晶, 竹澤芳樹, 兪志前, 菊地淑恵, 福與なおみ, 西村章, 松本直通

第17回日本精神・行動遺伝医学会　2010/02/11
FACS-array approach into immunological aspects of schizophrenia. International-presentation

Tomita H, Tanaka C, Yu

World Congress of Psychiatric Genetics 15th annual meeting　2010/02/02
ソトス症候群のスクリーニング・診断システム開発のための研究〜リンパ芽球を対象とするNSD1遺伝子の下流遺伝子のスクリーニングを中心に〜

富田博秋, 小野千晶, 竹澤芳樹, 福與なおみ, 植松貢, 土屋滋, 岡本伸彦, 黒澤健司, 松本直通

第９回東北出世前医学研究会　2010/01/30
Effect of Lithium Treatment on Gene Expression Profile of Human Monocyte-Dendritic Cells

Yu Z, Tanaka C, Tomita H

第39回日本免疫学会総会・学術集会　2009/12/02
Microarray Gene Expression Profiling of Th1/Th2 helper T Cells as a Tool for Neuropsychoimmunology

Ono C, Yu Z, Ishii N, Tomita H

第39回日本免疫学会総会・学術集会　2009/12/02
気分安定薬バルプロ酸とラモトリギン投与時のヒト脳細胞における遺伝子発現変化のマイクロアレイ解析による包括的検討

田邊陽一郎, 田中千晶, 兪志前, 小松浩, 木村好, 羽藤愛, 松岡洋夫, 曽良一郎, 富田博秋

第8回Bipolar Disorder研究会　2009/11/22
気分安定薬リチウムの樹状細胞における遺伝子発現変化の包括的検討

兪志前, 田中千晶, 田邊陽一郎, 小松浩, 木村好, 羽藤愛, 松岡洋夫, 曽良一郎, 富田博秋

第19回日本臨床精神神経薬理学会・第39回日本神経精神薬理学会合同年会　2009/11/13
気分安定薬投与によるオリゴデンドロサイトの遺伝子発現変化の解析

羽藤愛, 兪志前, 田中千晶, 田邊陽一郎, 小松浩, 木村好, 松岡洋夫, 曽良一郎, 富田博秋

第19回日本臨床精神神経薬理学会・第39回日本神経精神薬理学会合同年会　2009/11/13
ラモトリギン投与によるヒト脳由来細胞における包括的遺伝子発現の解析

田邊陽一郎, 田中千晶, 兪志前, 小松浩, 木村好, 羽藤愛, 松岡洋夫, 曽良一郎, 富田博秋

第19回日本臨床精神神経薬理学会・第39回日本神経精神薬理学会合同年会　2009/11/13
気分安定薬のアストロサイトにおける遺伝子発現変化の包括的検討

兪志前, 田中千晶, 小松浩, 高橋怜史, 木村好, 曽良一郎, 富田博秋

第31回日本生物学的精神医学会　2009/04/23
気分安定薬リチウムの樹状細胞における遺伝子発現変化の包括的検討

兪志前, 田中千晶, 小松浩, 木村好, 曽良一郎, 富田博秋

第29回リチウム研究会　2009/04/18
ゲノム研究を明日の精神科臨床に役立てるために

富田博秋

第101回岡山大学大学院医歯薬学総合研究科精神神経病態学教室臨床集談会　2008/12/15
Time-dependent genome-wide gene expression study of neural cells after lithium treatment.

Takahashi S, Tanaka C, Yu Z, Kimura K, Sora I, Tomita H

第31回日本分子生物学会年会・第81回日本生化学会大会合同大会　2008/12/09
Hypoxia-induced gene expression profiling in neuron and oligodendrocyte. International-presentation

Tomita H, Tanaka C, Yu Z, Kimura K, Bunney WE

Society for Neuroscience 38th annual meeting　2008/11/15
A comprehensive gene expression analysis of the locus coeruleus noradernergic neurons during early development by the FACS-array technology. International-presentation

Itoi K, Nakamura H, Yokokawa T, Sato Y, Kobayashi K, Tanaka C, Tomita H, Uchida K, Iwasaki Y, Ishii Y

Society for Neuroscience 38th annual meeting　2008/11/15
Microarray gene expression profiling of Th1/Th2 helper t cells as a tool for neuropsychoimmunology. International-presentation

Tanaka C, Yu Z, Kimura K, Ishii N, Tomita H

Society for Neuroscience 38th annual meeting　2008/11/15
Microarray gene expression profiles in neuronal and glial cell lines after lithium, valproate, carbamazepine and lamotrigine treatment International-presentation

Yu Z, Tanaka C, Komatsu H, Takahashi S, Kim HB, Kimura K, Sora I, Bunney WE, Tomita H

Society for Neuroscience 38th annual meeting　2008/11/15
Microarray gene expression analyses of neurons, astrocytes and, oligodendrocytes, and neurons after mood stabilizer treatment. International-presentation

Yu Z, Tanaka C, Komatu H, Takahashi S, Kimura K, Sora I, Tomita H

Tohoku University-Fudan University Neuroscience Workshop for Young Scientists.　2008/10/15
Effect of mood stabilizers on genome-wide gene expression profiles of human CNS-derived cell lines. International-presentation

Tomita H, Tanaka C, Yu Z, Takahashi S, Komatsu H

World Congress of Psychiatric Genetics 15th annual meeting　2008/10/11
Expression profiles of BDNF transcript variants in neuronal and glial cell lines after treatment with mood stabilizers. International-presentation

Komatsu H, Tanaka C, Yu Z, Kimura K, Takahashi S, Sora I, Matsuoka H, Tomita H

World Congress of Psychiatric Genetics 15th annual meeting　2008/10/11
低酸素状態下での脳内細胞種特異的遺伝子発現の包括的検討.

田中千晶, 兪志前, 木村好, 富田博秋

第53回日本人類遺伝学会　2008/09/27
双極性障害治療薬の神経細胞およびグリア細胞における遺伝子発現変化の包括的検討

兪志前, 田中千晶, 小松浩, 高橋怜史, 木村好, 富田博秋

第53回日本人類遺伝学会　2008/09/27
Microarray gene expression profiles in neuronal and glial cell lines after lithium, valproate, carbamazepine and lamotrigine treatment. International-presentation

Yu Z, Tanaka C, Komatsu H, Takahashi S, Kim HB, Kimura K, Sora I, Bunney WE, Tomita H

World Federation of Societies of Biological Psychiatry 2nd Asia-Pacific Congress　2008/09/11
The importance of quality control in brain bank management. International-presentation

Tomita H

World Federation of Societies of Biological Psychiatry 2nd Asia-Pacific Congress.　2008/09/11
Psychoneuroimmunology in schizophrenia. International-presentation

Tomita H

World Federation of Societies of Biological Psychiatry 2nd Asia-Pacific Congress　2008/09/11
気分調整薬がヒト神経由来細胞およびグリア由来細胞の各BDNF転写物バリアント発現量に及ぼす影響の検討.

小松浩, 田中千晶, 兪志前, 木村好, 高橋怜, 曽良一郎, 松岡洋夫, 富田博秋

第30回日本生物学的精神医学会　2008/09/11
Hypoxia-induced gene expression profiles of Neuron and Oligodendrocyte. International-presentation

Tanaka C, Ishikawa M, Tomita H

Collegium internationale neuro-psychopharmacologicum 50th congress　2008/07/13
Neuron- and glia- specific gene expression profiles after lithium treatment. International-presentation

Tomita H, Tanaka C, Kim HB, Bunney WE

Collegium internationale neuro-psychopharmacologicum 50th congress　2008/07/13
神経細胞およびグリア細胞における遺伝子発現プロファイルへのリチウムの影響.

富田博秋, 田中千秋, Helen B. Kim, William E. Bunney

第31回日本神経科学会　2008/07/09
ゲノム精神医学の現状と明日〜統合失調症・気分障害から消化器心身症まで〜

富田博秋

東三河消化器病懇話会学術講演会　2008/05/10
気分安定薬〜開発と奏効機序研究の歴史と現状〜

富田博秋

第65回石川県神経科精神科医学会学術講演会　2008/04/10
低酸素状態がニューロンおよびオリゴデンドロサイトに及ぼす分子遺伝学的変化の検討〜統合失調症死後脳研究に関連して〜

田中千晶, 石川美由紀, 富田博秋

第3回日本統合失調症学会　2008/03/15
低酸素状態がニューロンおよびオリゴデンドロサイトに及ぼす分子遺伝学的変化の検討〜統合失調症死後脳研究に関連して〜.

田中千晶, 石川美由紀, 富田博秋

第3回日本統合失調症学会　2008/03/15
気分安定薬は双極性障害に何故効くのか？〜基本から最新の研究情報まで〜

富田博秋

デパケン双極性障害適応拡大５周年記念講演会　2008/02/01
気分安定薬は双極性障害に何故効くのか？

富田博秋

バルプロ酸学術講演会　2008/02/01
低酸素状態下での脳内細胞種特異的遺伝子発現の包括的検討

田中千晶, 石川美由紀, 富田博秋

日本精神・行動遺伝医学会　2007/11/17
Microarray gene expression profiles in neuronal and glial cell lines after lithium treatment International-presentation

Hiroaki Tomita, Chiaki Tanaka, Helen B. Kim, William E. Bunney

Society for Neuroscience　2007/11/03
精神疾患研究におけるミトコンドリア関連遺伝子の発現変化〜病態か、アーチファクトか？

富田博秋, 田中千晶

日本生物学的精神医学会　2007/07/11
リチウム投与によるニューロンおよびグリア特異的遺伝子発現変化

富田博秋, 服部寿妃, 坂本昌樹, 佐藤大樹, ヘレン・キム, ウィリアム・バニー

リチウム研究会　2007/04/21
認知機能障害評価の標準化としてのMATRICS-CCB

曽良一郎, 富田博秋

日本統合失調症学会　2007/03/24
リチウム投与による神経細胞およびグリア細胞培養細胞における遺伝子発現変化

服部寿妃, 有銘預世布, ヘレン・キム, ウィリアム・バニー, 富田博秋

日本精神・行動遺伝医学会　2006/11/18
気分障害の成因と治療奏効機序に関わる分子遺伝学的機序の解明

富田博秋

第5回宮城県うつ病治療研究会　2006/11/07
気分障害における死後脳研究と遺伝子発現

富田博秋

福島県立医大ブレインバンク・シンポジウム　2006/10/22
Effect of lithium on gene expression profiles International-presentation

Tomita H, Kim HB, Bunney WE

Society for Neuroscience 36th Annual Meeting　2006/10/14
Gene Expression Studies of Postmortem Brain

Tomita H, Kim HB, Choudary PV, Lopez JF, Thompson RC, Evans SJ, Li JZ, Vawter MP, Meng F, Walsh DM, Atz ME, Shao L, Overman KM, Myers RM, Jones EG, Watson SJ, Akil H, Bunney WE

第28回日本生物学的精神医学会・第36回日本神経精神薬理学会・第49回日本神経化学会大会三学会合同大会　2006/09/14

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Industrial Property Rights 1

Compositions and methods for diagnosing and treating neuropsychiatric disorders

Akil H, Atz Mary, Bunney WE, Byerley W, Casey K, Choudary PV, Evans SJ, Jones EG, Li J, Lopez JF, Myers RM, Rollins B, Thompson RC, Tomita H, Vawter MP, Watson SJ

Property Type: Patent

Research Projects 20

認知矯正療法と運動療法の併用効果と個別化医療に向けた三次元眼底撮影による効果予測

角藤芳久, 内海裕介, 富田博秋, 小松浩

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2022/04/01 - 2027/03/31
Development of biomarker for postpartum depression using GWAS and metabolomics

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Nagoya University

2021/04/01 - 2024/03/31
The Actual Conditions of Ethical Consideration on Research Involving Human Subjects

Hiroaki Tomita, IIJIMA Yoshihiko, NEMOTO Harumi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2015/04/01 - 2017/03/31

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While surveys of people affected by the Great East Japan Earthquake under recognition by related agencies of local governments were conducted with approvals from ethical committees and informed consents from subjects, many surveys of affected people were conducted beyond recognition by local governments, which could potentially lack proper ethical considerations. While researchers in medical fields generally conducted surveys following the ethical guidelines for medical research, ethical considerations varied among researchers in other research fields. Consensus regarding ethical considerations on surveys of people affected by a disaster should be made and shared among societies to prevent disadvantages which affected people can suffer.
Psychosocial effect, lifestyle change, and disaster influence among the chronic disease patients under the catastrophic stress

Naoki Nakaya, HOZAWA ATSUSHI, TOMITA HIROAKI, TSUCHIYA NAHO, NAKAMURA TOMOHIRO

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2014/04/01 - 2017/03/31

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This study examined the psychosocial adverse effect, lifestyle change, and disaster influence among the chronic disease patients in the earthquake disaster area. We used data obtained from a population-based study of over 4,000 subjects to investigate the associations between medical treatments for chronic diseases (e.g. stroke, cancer, myocardial infarction), psychosocial adverse effects (psychological distress and depressive symptoms), lifestyle changes (smoking, alcohol, and sleeping status) and the degree of damage to homes (large-scale and small-degree). There was statistically significant increased risk of psychological distress among chronic disease patients to compare with non-chronic disease patients. The chronic disease patients show higher psychological distress among victims assumed to be high in a psychological distress. The need of the psychological support was shown as well as the physical care for the chronic disease patient.
Investigations into psychoneuroimmunology-relevant microendophenotypes of psychiatric disorders

Tomita Hiroaki, YU Zhiqian

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Institution: Tohoku University

2012/06/28 - 2017/03/31

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An intra-field collaborative research with Kida group (A03) has identified microglial cytokine production profiles as microendophenotypes of formation and maintenance of fear memory utilizing a mouse model of posttraumatic stress disorder. Also, a research with Hashimoto group (A02) has indicated altered methylation pattern of glial cell-related gene loci as the pathogeneses of schizophrenia caused by immune stress on maternal body during a fetal period. Furthermore, technologies to identify subpopulations of immune cells related to psychiatric disorders, and an immune-related microendophenotype relevant to the efficacy of a mood stabilizer were developed.
Unraveling the micro-endophenotypes of psychiatric disorders at the molecular, cellular and circuit levels

Kida Satoshi, HASHIMOTO Kenji, TOMITA Hiroaki, NAWA Hiroyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Institution: Tokyo University of Agriculture

2012/06/28 - 2017/03/31

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To develop basic research on psychiatric disorders, we tried to identify “micro-endophenotypes” that are the visualized phenotypes of psychiatric disorders at the molecular, cellular and circuit levels, as an interface between basic and clinical studies, and understand their molecular basis. To do this, we had more than 7 meetings to present and share our findings and employed support activities for scientist in this innovative area by providing with analyses of next generation sequence and epigenome, imaging using two-photon excitation microscopy and STORM/STED, iPS cells derived from patients of psychiatric disorders and so on. We also encouraged young scientists to join basic research fields of psychiatric disorders. Through these activities, we identified candidates of micro-endophenotypes of psychiatric disorders such as schizophrenia, bipolar disorders, PTSD and depression and furthermore, developed state-of-the-art technologies to identify and analyze micro-endophenotypes.
Comprehensive Brain Science Network

Kimura Minoru, Tanji Jun, Takada Masahiko, Nakamura Katsuki, Ohtsuka Toshihisa, Aoki Shigeki, Takao Hidemasa, Shimoji Keigo, Goto Masami, Yoshiura Takashi, Nakata Yasuhiro, Abe Osamu, Masumoto Tomohiko, Tokumaru Aya, Matsumura Akira, Kirino Eiji, Terada Hitoshi, Sato Noriko, Kasai Kiyoto, Hashimoto Ryota, Niwa Shin-ichi, Kato Tadafumi, Suzuki Michio, Shuji Iritani, Nemoto Kiyotaka, Tomita Hiroaki, Murayama Shigeo, Akatsu Hiroyasu, Takao Masaki, Saito Yuko, Bito Haruhiko, Yoshimura Yumiko, Matsuzaki Masanori, Furuta Toshiaki, Okado Haruo, Saito Izumu, Kaibuchi Kozo, Hasegawa Masato, Aiba Atsu, Shiina Nobuyuki, Igarashi Michihiro, Tomoki Nishioka, Watanabe Masahiko, Koike Masato, Sakagami Hiroyuki, Shigemoto Ryuichi, Fukazawa Yugo, Sakimura Kenji, Mori Hisashi, Mishina Masayoshi, Kobayashi Kazuto, Yanagawa Yuchio, Uemura Tadashi, Ishihara Takeshi, Nose Akinao, Iino Yuichi, Miyakawa Tsuyoshi, Takao Keizo, Mushiake Hajime, Katayama Norihiro, Tanaka Tetsu, Inoue Kazuhide, Okabe Shigeo, Kano Masanobu, Fujiyama Fumino, Isa Tadashi, Kageyama Ryoichiro, Fujita Ichiro, Yoshida Akira, Nishikawa Toru, Nukina Nobuyuki, Fukai Tomoki, Iwatsubo Takeshi, Yamamori Tetsuo, Okazawa Hitoshi, Tanaka Keiji, Kakigi Ryusuke, Tsuda Ichiro, Kitazawa Shigeru, Doya Kenji, Takahashi Ryosuke, Ikenaka Kazuhiro, Sobue Gen, Hasegawa Toshikazu, Ota Jun, Saitoe Minoru, Kadomatsu Kenji, Kida Satoshi, Manabe Toshiya, Tomita Taisuke, Iwata Atsushi, Murakami Ikuya, Tsutsui Ken-ichiro, Hanakawa Takashi, Hirai Hirokazu, Mima Tatsuya, Isomura Yoshikazu, Samejima Kazuyuki, Hoshi Eiji, Miyata Mariko, Yuzaki Michisuke, Tanaka Masaki, Fukata Masaki, Suzuki Kyoko, Kuba Hiroshi, Masu Masayuki, Kinoshita Makoto, Sugihara Izumi, Shirane Michiko, Yamamoto Nobuhiko, Nishijo Hisao, Nambu Atsushi, Takumi Toru, Yamashita Toshihide, Sakurai Takeshi, Tamamaki Nobuaki, Hata Yoshio, Harada Akihiro, Ozaki Norio, Sakai Katsuyuki, Kubo Yoshihiro, Nakazawa Takanobu, Tanaka Kenji, Takei Nobuyuki, Hitoshi Seiji, Takahiroa. Kato, Kato Fusao, Shirao Tomoaki, Taira Masato, Okano Hideyuki, Sekino Yuko, Okamoto Yasumasa, KOMATSU Hidehiko, Miyata Takaki, Takahashi Yoshiko, Nishida Shinya, Tominaga Makoto

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Institution: Center for Novel Science Initatives, National Institutes of Natural Sciences

2010/04/01 - 2016/03/31

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The Comprehensive Brain Science Network (CSBN) provided individual researches supported by Grant-in-Aid for Scientific Research with cutting-edge resources and technologies, such as model animals, postmortem brain tissue, optical technologies for imaging and manipulation, virus vectors and more. Support covered researches on neuron-specific genes and molecules, synapse, network system, brain functions in disease states and neuro-computation. Special support was directed to collaboration between different fields. Workshop was held to have joint symposia among fields of peoples, to have a special session to let neuroscience community members share knowledge of how current researches are supported in Japan and discuss about future. Graduate students and postdoctoral fellows were supported to visit other laboratories of different field in Japan and abroad and learn disciplines, and award those who presented high quality work the CBSN Prize. These supports promoted break through from conventional approaches and publication of a number of papers with very high quality.
Relationship among brain structure, genetic factor, lifestyle, and cognitive functions

TAKI Yasuyuki, TOMITA Hiroaki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2011/04/01 - 2015/03/31

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We have collected brain magnetic resonance imaging, cognitive function, gene, and lifestyle data from healthy subjects. As a result, We have shown that the rate of brain volume decline with aging, that relationship between brain volume decline rate and lifestyle such as sleeping habit, and that relationship between brain volume declune rate and genetic factor. These results are useful for early diagnosis of dementia as well as maintaining healthy brain throughout life.
Establishment of biological research linked with community mental health service

TOMITA Hiroaki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2012 - 2012

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Considerations in conducting mental health promotion and health survey were summarized. Saliva samples from victims of the Great East Japan Earthquake of2011 were collected upon informed-consent, and difference in comprehensive gene expression profiles of the samples between groups showing high- and lowpost-traumatic stress responses were analyzed. Data indicated the validity of analyzing saliva samples as an indicator of post-traumatic stress, as long as considerations on proportion of each component cell type in saliva.
Development of clinical marker to predict longitudinal prognosis of early psychosis

MATSUMOTO Kazunori, MATSUOKA Hiroo, MUGIKURA Syunji, TOMITA Hiroaki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2010 - 2012

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To develop useful and reliable clinical markers to predict the longitudinal prognosis of early psychosis, we investigated clinical variables of at risk mental state (ARMS) and first episode psychosis (FEP) at intake and follow-up. In our sample of 116 patients with ARMS, 14% transited to psychosis. Cognitive performance improved to a greater extent in patients with ARMS than in those with FEP. The present findings indicate the importance of using multiple clinical variables in combination to assess and predict the functionalprognosis of early psychosis.
躁うつ病治療薬の脳内ミクログリアと末梢モノサイト系細胞への影響の包括的検討

富田博秋, YU Z., YU Zhiqian

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 特別研究員奨励費

Institution: 東北大学

2009 - 2011

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リチウムの双極性障害治療における有用性は確立しているもののその効果には限界があり,また,作用機序に不明な点が多いため,より有効な治療薬の開発や治療反応性の予測が難しい.一方,脳内の単球系細胞であるミクログリアや樹状細胞が双極性障害を含む中枢神経疾患の病態の進行や改善に関与していることが示唆されており,双極性障害の罹患者では末梢単球から樹状細胞への分化が障害され,自己抗原に対するT細胞反応が抑制され,リチウムの投与により双極障害罹患者における単球から樹状細胞への分化阻害が改善することが報告されている.申請者らはリチウムの単球系細胞への影響を介した双極性障害への奏功機序を想定して,抗CD11b,CD11c磁気ビーズ抗体などを用いた単球系細胞の単離とマイクロアレイ遺伝子発現プロファイリングなどの技術を駆使して下記の研究を行った.(1)リチウム投与によるヒト単球から樹状細胞への分化プロセスに及ぼす影響に関わる分子群の特定.(2)リチウム投与によりマウスの同一固体からの末梢単球と脳内単球系細胞に共通に影響を受ける分子群の特定.これらの解析結果を併せて検討したところ,リチウムがヒト単球から樹状細胞に分化誘導する際に発現を顕著に促進する分子群とリチウムがマウス脳内単球系細胞において顕著に発現を促進する分子群との間に共通性がみられ,リチウムはこれらの分子群の発現誘導を行うことで単球系細胞機能に影響を及ぼすことが想定された.この結果をウエスタンブロット、ELISAなどを用いたタンパク質発現のレベルで検証したり、また、遺伝子発現調節メカニズム解明の機能解析も行った。本研究の成果はリチウムの単球系細胞への影響を介した双極性障害への奏功機序の解明に有用と考えられる.
統合失調症陰性症状の成因解明と治療法開発に関する研究 Competitive

2007/04 - 2010/03
気分調整薬の奏効機序に関与する細胞特異的遺伝子発現の同定 Competitive

2007/04 - 2009/03
Identification of Schizophrenia-susceptible Ep igenetic Marker Engraved by Environmental Factor Competitive

TOMITA Hiroaki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2009 - 2009

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As a model of molecular mechanisms of susceptibility to schizophrenia, increased by e xposure to the environmental factors, including hypoxia and immune response, during neonatal period, DNA methylation patterns engraved by the neonatal exposures, and susta ined throughout the life were proposed, and the fo llowing research has been conducted. 1)Identification of DNA methylation patterns in human neuronal cell lines exposed to hypoxia. 2)Identification of epigenomic conditions in adult mice brain which were exposed to neonatal immune responses to viral infection. 3)Evaluation of epigenomic conditions of schizophrenic postmortem brains.
精神疾患脳バンク構築のための基礎研究 Competitive

富田博秋

Offer Organization: 文部科学省

System: 科学研究費補助金(特定領域研究)

Category: 特定領域研究

Institution: 東北大学

2008 - 2009

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精神疾患の成因解明のための死後脳研究を行う上で慎重な考慮が必要な交絡因子のうち、死戦状態、特に低酸素暴露の脳内の遺伝子転写物への影響を適切に評価し影響を最小限にコントロールするプロトコルを策定するため、ヒト神経細胞、グリア細胞由来の培養細胞の低酸素暴露による遺伝子転写への影響と死亡時低酸素暴露による死後脳組織への転写物への影響を比較し、死戦期の低酸素暴露が死後脳組織の遺伝子転写調節に及ぼす影響を包括的に検討した。低酸素状態に曝された神経細胞由来SK-N-SH細胞はミトコンドリア機能が活性化したが、細胞数には変化を認めなかった。オリゴデンドロサイト由来OL細胞では低酸素暴露によりミトコンドリア機能の増加傾向、有意な乳酸産生の増加がみられ、細胞数が顕著に減少した。アストロサイト由来SVGp12細胞においては細胞数、ミトコンドリア機能ともに顕著な変化は認められなかった。マイクロアレイ解析を行った結果、遺伝子発現レベルでもオリゴデンドロサイトでは他の細胞種に比べ大きな影響が観察された。発現変化を受ける遺伝子の種類は神経細胞と比して、グリア細胞間で全般に高い類似性が認められ、中でも糖代謝系に関わる遺伝子が共通して発現変化を受けていた。低酸素暴露により脳内細胞と末梢組織細胞でともに発現変化する遺伝子を細胞種間で普遍的な低酸素状態暴露履歴のマーカーとして特定した。また、低酸素などの死戦期状況に暴露しpHが低下した死後脳組織と暴露が少なく生理的pHに近く保たれた組織との遺伝子発現プロファイルの相違と低酸素暴露した神経細胞、グリア細胞の遺伝子発現プロファイルを比べ、死後脳組織の低酸素暴露履歴のマーカーを特定した。本研究により低酸素暴露による脳内細胞の細胞種特異的変化や細胞種間に共通の変化が包括的に把握され、死後脳組織の死戦期における低酸素暴露の履歴をより適確に評価することが可能になった。
Comprehensive Molecular Genetics to Elucidate The Mechanism of Action of Mood Stabilizers Competitive

TOMITA Hiroaki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2007 - 2008
前頭前野皮質に特徴的なモノアミン神経伝達制御の役割 Competitive

曽良一郎, 富田博秋

Offer Organization: 文部科学省

System: 科学研究費補助金(特定領域研究)

Category: 特定領域研究

Institution: 東北大学

2006 - 2007

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ドーパミン神経伝達が過剰なドーパミントランスポーター(DAT)欠損マウスにおけるプレパルス・インヒビション(PPI)の改善には前頭前野におけるドーパミンの動態が関与している可能性が考えられた。DAT欠損マウスにおけるノルエピネフリントランスポーター(NET)阻害によるPPIの改善に関与する脳部位および神経回路を明らかにするため、野生型あるいはDAT欠損マウスに選択的NET阻害剤ニソキセチンを局所投与し、PPIを測定した。前頭前野皮質へのニソキセチン局所投与でPPIは改善した。ニソキセチンの全身役与によるPPIの改善効果と前頭前野皮質の関与を調べるため神経興奮のマーカーであるc-Fosを用いて神経活性化のマッピングを行った。十分に環境に馴化させた野生型あるいはDAT欠損マウスにニソキセチンを投与し、投c-Fos抗体を用いて免疫組織化学的にc-Fos陽性細胞を計数したところ、内側前頭前野皮質ではDAT欠損マウスでニソキセチンの腹腔内投与により生食投与群と比較して有意にc-Fos陽性細胞の数が増加した。これはNET阻害剤であるニソキセチンの全身投与により前頭前野のドーパミン神経伝達が賦活され、ドーパミンの神経支配を受ける前頭前野でシナプス後細胞が活性化させることを示唆した。また、これらの結果より前頭前野へのニソキセチン局所投与においても同様な作用が働いていることが予想された。以上の...
遺伝的個人差に基づくオピオイド鎮痛薬によるがん疼痛緩和 Competitive

曽良一郎, 富田博秋

Offer Organization: 文部科学省

System: 科学研究費補助金(特定領域研究)

Category: 特定領域研究

Institution: 東北大学

2006 - 2007

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がん疼痛を含む末梢神経障害疼痛の緩和は患者のQOLの改善に有用である。モルヒネを代表とするオピオイド類は強力な鎮痛効果をもち、がん疼痛患者の第一選択薬である。一方で嘔気・便秘・依存・耐性等の副作用が治療の大きな妨げとなっている。オピオイドの鎮痛効果や副作用には個人差が存在し、様々な遺伝子多型が関係していると考えられる。副作用や鎮痛効果と遺伝子多型との関連を明らかにすることは、個々人にあったテーラーメイド医療の確立に役立つと考えられる。そこで、我々は本研究において、オピオイド投与中のがん疼痛患者を対象に、オピオイド標的受容体であるμオピオイド受容体遺伝子(OPRM1)・δオピオイド受容体遺伝子(OPRD1)・Kオピオイド受容体遺伝子(OPRK1)およびオピオイドの嘔気と関連のあるドーパミンD2受容体遺伝子(DRD2)の一塩基多型(singlenucleotide polymorphism:SNP)が、主観的な痛みの強さや、副作用の強さに影響するか検討した。その結果、オキシコドン投与群では、DRD2の多型で、食欲不振の強さと有意な関連を認めた。一方、モルヒネ投与群では、OPRD1の多型で、痛みの改善率と有意な関連があり、OPRKIの多型で、神経因性疼痛の強さ、BPIの平均値と有意な関連を認めた。
Regulatory mechanisms of prefrontal cortex in cognitive deficit of schizophrenia Competitive

SORA Ichiro, TOMITA Hiroaki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2005 - 2006

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1. Dopamine transporter knockout (DAT KO) mice display deficits in sensorimotor gating that are manifested by reduced prepulse inhibition (PPI) of the acoustic startle reflex. Since PPI deficits may model some of the cognitive dysfunctions identified in certain neuropsychiatric patients, we have studied the effects of transporter blockers on PPI in wild-type and DAT KO mice. Treatments with high dose psychostimulants that block DAT as well as the norepinephrine (NET) and serotonin (SERT) transporters significantly impaired PPI in wild-type mice. By contrast, these treatments significantly ameliorated the PPI deficits observed in untreated DAT KO mice. In studies with more selective transport inhibitors, the selective NET inhibitor nisoxetine also significantly reversed PPI deficits in DAT KO mice. By contrast, while the SERT inhibitor fluoxetine normalized these PPI deficits in DAT KO mice, citalopram failed to do so. The 'paradoxical' effects of cocaine and methylphenidate in DAT KO mice are thus likely to be mediated, at least in part by the ability of these drugs to block NET, although serotonin systems may also have some role. Together with recent microdialysis data,-these results support the hypothesis that prefrontal cortical NET blockade and consequent enhancement of prefrontal cortical extracellular dopamine mediates the reversal of PPI deficits in DAT KO mice. 2. Prepulse inhibition of perceived stimulus intensity (PPI-PSI) is a robust, stable, and convenient method for measurement of sensory gating which is relatively unaffected by a number of biological variables, e.g., sex differences, menstrual cycle, or personality dimensions, in healthy individuals. Patients with schizophrenia showed significantly less PPI-PSI compared with control subjects. The PPI-PSI deficits were significantly correlated with the "thought-disorder" schizophrenia score extracted from the Brief Psychiatric Rating Scale (BPRS). These results provide additional evidence for the notion that schizophrenia is characterized by sensory gating deficits. In addition, PPI-PSI was found to be correlated with integrated clinical symptoms typical of schizophrenia. Our findings suggested that PPI-PSI could be useful for assessing the severity of schizophrenia.
発作性運動誘発性コレオアテトーシスの連鎖解析 Competitive

富田博秋

Offer Organization: 文部科学省

System: 科学研究費補助金(奨励研究(A))

Category: 奨励研究(A)

Institution: 長崎大学

1998 - 1999

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「発作性運動誘発性コレオアテトーシスをはじめとする遺伝性疾患の遺伝子座位の同定および責任遺伝子の単離を目的として研究を行った。発作性運動誘発性コレオアテトーシス罹患者43名を含む8家系84名の構成員からインフォームド・コンセントを得て、ゲノム全体を包括する約400の多型マーカーを用いて連鎖解析を行った。2点連鎖解析でD16S3081において最大のLOD値10.27(組み換え率0.00、浸透率0.7)、多点連鎖解析でD16S3080において最大のLOD値11.51(浸透率0.8)を得た。また、ハプロタイプ解析の結果から、本疾患の責任遺伝子はD16S3093からD16S416までの12.4cMに局在すると考えられた。また、FISHの結果から、この責任領域は16番染色体16p11.2-q12.1の領域に局在することが分かった(Am J Hum Genet.1999,65:1688-1697.)。また、Engelmann病罹患者15名を含む2家系27名の構成員からインフォームド・コンセントを得て、ゲノム全体を包括して連鎖解析を行った。2点連鎖解析でD19S918において最大のLOD値5.81(組み換え率0.00、浸透率0.9)を得、ハプロタイプ解析の結果から、本疾患の責任遺伝子は19番染色体D19S422からD19S606までの15.1cMに局在すると考えられた(Am J Hum G...

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メンタルヘルス研修

七ヶ浜町役場メンタルヘルス研修会

2019/03/07 - 2019/03/07
大災害とメンタルヘルス～報道機関従事者が備えるべきこと～

NKH仙台災害報道研修会

2018/09/21 - 2018/09/21

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次世代シークエンサーを駆使した希少遺伝性難病の原因解明と治療法開発の研究

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次世代シークエンサーを駆使した希少遺伝性難病の原因解明と治療法開発の研究
ソトス症候群のスクリーニング・診断システムの開発と実用化

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ソトス症候群のスクリーニング・診断システムの開発と実用化
ソトス症候群のスクリーニング・診断システムの確立

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ソトス症候群のスクリーニング・診断システムの確立
精神・神経疾患に関するバイオマーカーの探索及び診断・治療法の開発に関する研究

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精神・神経疾患に関するバイオマーカーの探索及び診断・治療法の開発に関する研究
免疫細胞種特異的な遺伝子発現プロファイリングの同定

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免疫細胞種特異的な遺伝子発現プロファイリングの同定
Gene Expression Profiling of Monoaminergic Neurons

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モノアミン神経遺伝子発現プロファイリングに関する共同研究で当方はマイクロアレイ解析を中心に担当する。
ブレインバンク・ワーキンググループ

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日本における精神医学研究のための死後脳組織を対象とする分子遺伝学的研究を推進するための脳バンク・ネットワーク設立準備のためのワークグループ
統合失調症陰性症状の成因解明と治療法開発に関する研究

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下記の３つのアプローチを統合することで統合失調症の陰性症状の形成・進行及び脳萎縮に関わる分子遺伝学的機序を解明し、陰性症状の治療法・予防法の開発に繋げる。？統合失調症罹患者及び健常対照者の各種免疫細胞の機能を評価した上でマイクロアレイ技術を用いて全ゲノムの遺伝子発現量を包括的に評価し、統合失調症陰性症状及び脳組織の萎縮の形成・進行に関与する免疫細胞における分子遺伝学的変化を特定する。？上記と同じ統合失調症罹患者及び健常対照者の臨床所見・脳画像所見・50万種のゲノム多型情報を統合して統合失調症陰性症状及び脳組織の萎縮の形成・進行に関与するゲノム多型を特定する。？統合失調症罹患者及び健常対照者の死後脳組織を対象とする解析により各脳部位や各細胞種で統合失調症の陰性症状の病態形成に関与する分子遺伝学的変化を特定する。
気分調整薬の奏効機序に関わる分子遺伝学的

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気分調整薬の奏効機序に関わる分子遺伝学的
Genetic and Neuropathological Abnormalities in Neuropsychiatric and Neurological Disorders

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精神疾患罹患者死後脳を対象とするマイクロアレイ遺伝子発現解析、気分障害の多型解析研究など
双極性気分障害におけるフォスフォセリン・フォスファターゼ相同性遺伝子の関与の可能性の検討

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双極性気分障害におけるフォスフォセリン・フォスファターゼ相同性遺伝子の関与の可能性の検討

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