Details of the Researcher

PHOTO

Yoichiro Asai
Section
Tohoku University Hospital
Job title
Assistant Professor
Degree

Research Areas 1

  • Life sciences / Metabolism and endocrinology /

Research Projects 3

  1. Association of blood glucose variability and home hypertension with dementia-related brain findings: a machine learning study

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Teikyo University

    2024/04/01 - 2028/03/31

  2. The involvement of the liver in hyperinsulinemia associated with obesity

    Yoichiro Asai

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Early-Career Scientists

    Institution: Tohoku University

    2020/04/01 - 2022/03/31

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    The involvement of the liver in hyperinsulinemia associated with obesity was investigated. High fat diet (HFD) feeding caused obesity and liver steatosis in wild type mice. Hepatic insulin clearance was decreased in obese mice. The expression levels of the molecules involved in insulin degradation were decreased in the livers of obese mice. Scanning electron microscopy revealed that fenestrations in liver sinusoidal endothelial cells (LSECs) were decreased in HFD-fed mice. These results may be involved in decreased hepatic insulin clearance and hyperinsulinemia in obese mice. RNA-seq analyses of LSECs revealed gene expression s of inflammatory response and extra-cellular matrix were up-regulated in HFD-fed mice.

  3. The mechanism of the effect of Alzheimer's disease on the systemic glucose metabolism

    Asai Yoichiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Early-Career Scientists

    Institution: Tohoku University

    2018/04/01 - 2020/03/31

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    The effects of sporadic Alzheimer's disease on systemic glucose metabolism were investigated. The intra-cerebroventricular injection of streptozotocin(STZ) caused wild type mice cognitive dysfunction. The inflammation with the increase of microglia was observed in the areas of hippocampus and entorhinal cortex of STZ-icv mice. Furthermore, STZ-icv mice exhibited hyper-insulinemia and insulin resistance. The expression levels of insulin signal-related genes were different between the liver and the skeletal muscles. These results suggest the possibility that Alzheimer's disease itself may bring systemic insulin resistance.