Details of the Researcher

PHOTO

Masayuki Yasuda
Section
Tohoku University Hospital
Job title
Assistant Professor
Degree

Research History 1

  • Tohoku University University Hospital, Ophthalmology　Assistant Professor

Research Areas 1

  • Life sciences / Ophthalmology /

Papers 84

  1. Linking the Heart-Eye-Brain Axis: Ocular and Cerebral Blood Flow Changes After Catheter Ablation in Atrial Fibrillation. International-journal

    Nobuhiko Yamamoto, Hideaki Suzuki, Makoto Nakano, Shinich Yamanaka, Tomohiro Ito, Hiroyuki Sato, Takahiko Chiba, Kotaro Nochioka, Kentaro Takanami, Masayuki Yasuda, Hiroshi Kunikata, Toru Nakazawa, Satoshi Yasuda

    Heart rhythm　2026/02/09

    DOI： 10.1016/j.hrthm.2026.02.003 　

  2. Safety and Efficacy of Orally Administered SJP-0008 in Central Retinal Artery Occlusion: A Phase IIa Randomized Clinical Trial

    Satoru Tsuda, Hiroshi Kunikata, Kazuki Hashimoto, Toshifumi Asano, Azusa Ito, Mitsuhide Yoshida, Masayuki Yasuda, Fumihiko Nitta, Toru Nakazawa

    OPHTHALMOLOGY SCIENCE　6　(1)　2026/01

    DOI： 10.1016/j.xops.2025.100965 　

    ISSN： 2666-9145

  3. Safety and Efficacy of Orally Administered SJP-0008 in Central Retinal Artery Occlusion: A Phase IIa Randomized Clinical Trial. International-journal

    Satoru Tsuda, Hiroshi Kunikata, Kazuki Hashimoto, Toshifumi Asano, Azusa Ito, Mitsuhide Yoshida, Masayuki Yasuda, Fumihiko Nitta, Toru Nakazawa

    Ophthalmology science　6　(1)　100965-100965　2026/01

    DOI： 10.1016/j.xops.2025.100965 　

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    PURPOSE: To assess the efficacy and safety of orally administered calpain inhibitor SJP-0008 in Japanese patients with central retinal artery occlusion (CRAO), to establish a disease registry for the prospective tracking of observational data from patients with CRAO, intended for regulatory use, and to support the development of new therapeutic agents for CRAO. DESIGN: This was a 2-part study. Part 1 was a physician-/investigator-initiated, phase IIa, single-center, randomized, double-blinded, parallel-group study. Part 2 was a prospective cohort study, during which the CRAO registry was established, and included patients diagnosed with CRAO (including a nonrandomized registry cohort, the non-SJP group, which did not receive SJP-0008). Additionally, in part 2, a combined analysis was performed using data from part 1 patients. PARTICIPANTS: The study participants were patients recruited within 48 hours of developing CRAO. METHODS: SJP-0008 administration was initiated at least 3 hours but no more than 48 hours after the onset of CRAO. Patients were randomized in a 1:1 ratio using masked randomization to receive either 100-mg or 200-mg doses of SJP-0008. The dosing period was defined as the 4-week postinitiation period (up to 29 days), followed by an 8-week postobservation phase. MAIN OUTCOME MEASURES: The main outcome measure was to determine the efficacy of SJP-0008 treatment; the primary endpoint was the change in ETDRS visual acuity at 12 weeks in the target eye of patients with CRAO. RESULTS: The study included 28 patients (mean age: 68.8 ± 14.9 years; 78.6% male). ETDRS scores (mean [95% confidence interval]) were higher at week 12 than at baseline in both the 100-mg (27.9 letters [10.14, 45.61]) and 200-mg (25.7 letters [12.02, 39.40]) SJP-0008 groups, in contrast to the non-SJP group (10.2 letters [4.58, 15.76]). The improvement in the 200-mg SJP-0008 group was greater than in the nonrandomized non-SJP group (P = 0.040). No safety concerns were identified. CONCLUSIONS: The preliminary study supports the safety and efficacy of oral administration of SJP-0008 for treating CRAO, with greater improvement compared with the nonrandomized registry cohort. However, large-scale, multicenter randomized controlled trials are warranted to validate the findings of this study. FINANCIAL DISCLOSURES: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

  4. Risk Score Predicting Primary Open-Angle Glaucoma Patients With Vascular Predisposition. International-journal

    Nana Takahashi, Yukihiro Shiga, Naoki Kiyota, Masayuki Yasuda, Naoki Takahashi, Kota Sato, Ryutaro Arita, Akiko Kikuchi, Shin Takayama, Tadashi Ishii, Toru Nakazawa

    Translational vision science & technology　14　(4)　9-9　2025/04/01

    DOI： 10.1167/tvst.14.4.9 　

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    PURPOSE: We tested the hypothesis that a questionnaire-based risk score predicts the prevalence of patients with primary open-angle glaucoma (POAG) with vascular predisposition. METHODS: The Flammer Syndrome Questionnaire (FSQ) was used to determine vascular risk scores in 823 healthy subjects and 512 patients with POAG. Next, we characterized blood flow pulsatility changes within the optic nerve head (ONH) in Flammer syndrome (FS) using laser speckle flowgraphy (LSFG) in 358 eyes of 206 patients with normal-tension glaucoma (NTG). Last, we examined the association between changes in Mean blur rate (MBRAve), an LSFG-derived ONH blood flow measurement, during cold provocation and the FSQ risk score in 56 eyes of 56 patients with NTG. RESULTS: Five FSQ-related symptoms were significantly associated in patients with POAG patients; cold hands/feet (odds ratio [OR] = 1.82), low blood pressure (BP; OR = 3.29), increased response to drugs (OR = 2.27), underweight (OR = 1.99), and tendency toward perfectionism (OR = 1.88). The vascular risk score showed the best discriminative accuracy in differentiating healthy subjects from patients with NTG (area under the curve [AUC] = 0.73). In the NTG eyes, ONH pulsatile blood flow in the FS group was characterized by greater pulsatility. Moreover, the negative correlation between the high FSQ risk score and the cold-induced ONH blood flow reduction was pronounced in eyes with NTG (correlation coefficient = -0.41). CONCLUSIONS: The FSQ risk score can be a screening tool to identify patients with POAG with increased vascular stiffness and further reduced ONH blood flow during cold stress. TRANSLATIONAL RELEVANCE: The vascular risk score may help tailor individual glaucoma care.

  5. Systemic oxidative stress levels and their associations with the risk of neovascular age-related macular degeneration and treatment response. International-journal

    Maiko Abe, Hiroshi Kunikata, Naoko Aizawa, Masayuki Yasuda, Fumihiko Nitta, Toshiaki Abe, Toru Nakazawa

    International journal of retina and vitreous　11　(1)　16-16　2025/02/10

    DOI： 10.1186/s40942-025-00632-1 　

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    PURPOSE: To investigate the association between oxidative stress (OS) and both the risk of neovascular age-related macular degeneration (nAMD) and the treatment response to intravitreal anti-vascular endothelial growth factor injections (anti-VEGF IVIs). METHODS: This retrospective study included 46 treatment-naïve nAMD eyes of 46 patients (26 male and 20 female) who received anti-VEGF IVIs with a "treat-and-extend" regimen following an initial loading phase for one year. The patients were divided into two groups according to the total number of anti-VEGF IVIs administered during the year: the "effective" group and the "resistant" group. OS was evaluated by diacron reactive oxygen metabolites (d-ROMs), biological antioxidant potential (BAP), and skin autofluorescence (SAF) at baseline. For comparison, 54 control subjects were recruited. RESULTS: There were no significant differences in d-ROM or BAP levels between control subjects and nAMD patients, regardless of sex, whereas SAF levels were higher in nAMD patients overall and in male nAMD patients than in controls (P < 0.001 for both). The effective and resistant groups included 30 and 16 eyes, respectively. Among the male nAMD patients, the effective and resistant groups had similar baseline characteristics, including age, smoking history, visual acuity, and central macular thickness; however, the resistant group had higher SAF levels (effective vs. resistant: 2.3 vs. 2.6 arbitrary units [AU]; P = 0.02). This finding was further supported by a multiple logistic regression analysis, which showed that the odds ratio for SAF was 1.57 per 0.1 AU increase (P = 0.01). CONCLUSION: SAF levels were significantly higher in nAMD patients than in controls. The total number of anti-VEGF IVIs required over one year in male nAMD patients depended on SAF levels, suggesting that the SAF levels may serve as a potential biomarker for the response to anti-VEGF IVIs in nAMD.

  6. Systemic Oxidative Stress Level as a Pathological and Prognostic Factor in Myopic Choroidal Neovascularization

    Jiying Wang, Hiroshi Kunikata, Masayuki Yasuda, Noriko Himori, Fumihiko Nitta, Toru Nakazawa

    Ophthalmology Science　4　(6)　2024/11/01

    DOI： 10.1016/j.xops.2024.100550 　

    eISSN： 2666-9145

  7. Ocular blood flow dynamics following sinus rhythm restoration through catheter ablation: laser speckle flowgraphy in patients with persistent atrial fibrillation. International-journal

    Nobuhiko Yamamoto, Makoto Nakano, Kotaro Nochioka, Masayuki Yasuda, Hiroshi Kunikata, Toru Nakazawa, Satoshi Yasuda

    European heart journal. Imaging methods and practice　2　(3)　qyae071　2024/07

    DOI： 10.1093/ehjimp/qyae071 　

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    AIMS: Laser speckle flowgraphy (LSFG) is a well-established tool renowned for its non-invasive and reproducible assessment of ocular blood flow. While rhythm control therapies, such as catheter ablation (CA), have shown promise in enhancing cognitive function in atrial fibrillation (AF) patients, the acute impact of CA on microcirculatory changes, particularly in ocular blood flow, remains a topic of limited understanding. The present study aims to delve into the potential of LSFG in detecting microcirculatory alterations following the restoration of sinus rhythm (SR) through CA in patients with AF. METHODS AND RESULTS: We studied 8 paroxysmal AF (Paf) and 20 persistent AF (PeAF) patients (mean age 67 ± 6 years, 26% female) undergoing CA. Ocular blood flow was assessed using LSFG by measuring the mean blur rate (MBR) pre- and post-CA. Post-CA, all PeAF patients achieved SR restoration, resulting in a significant increase in tissue MBR (10.0 ± 2.2 to 10.8 ± 2.9, P = 0.021). In contrast, Paf patients showed no significant difference between pre- and post-MBR (12.0 ± 2.7 vs. 11.8 ± 2.6, P = 0.76). CONCLUSION: LSFG analysis effectively identified microcirculatory changes in patients undergoing CA for PeAF, suggesting that therapeutic interventions targeting the heart may have broader implications for ocular and cerebral health, establishing a novel 'cardio-oculo-cerebral relationship'.

  8. Relationship between oxidative stress level and diabetic retinopathy severity. International-journal

    Tatsu Okabe, Hiroshi Kunikata, Masayuki Yasuda, Toru Nakazawa

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie　2024/06/29

    DOI： 10.1007/s00417-024-06563-1 　

  9. Changes in ocular blood flow in patients with neovascular age-related macular degeneration after intravitreal injection of ranibizumab biosimilar and brolucizumab. International-journal

    Hiroki Takizawa, Masayuki Yasuda, Keisuke Hoshi, Tatsu Okabe, Hiroshi Kunikata, Toru Nakazawa

    International ophthalmology　44　(1)　181-181　2024/04/16

    DOI： 10.1007/s10792-024-03107-8 　

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    PURPOSE: To assess ocular blood flow (OBF) changes in patients with neovascular age-related macular degeneration (nAMD) treated with intravitreal injections of ranibizumab biosimilar (IVRbs) or brolucizumab (IVBr). METHODS: This retrospective longitudinal study included 43 eyes of 43 patients (74.5 ± 9.8 years old, male to female ratio 31:12) with nAMD treated with IVBr (29 eyes) or IVRbs (14 eyes). OBF in the optic nerve head (ONH) and choroid (Ch) was measured with laser speckle flowgraphy (Softcare Co., Ltd., Fukutsu, Japan) before and one month after treatment. Changes in mean blur rate (MBR) before and after each treatment were tested using Wilcoxon's signed-rank tests and mixed-effect models for repeated measures. RESULTS: In the IVBr group, MBR was significantly reduced in both the ONH and Ch (p < 0.01). In contrast, the IVRbs group showed no significant change in MBR in either the ONH or Ch (p = 0.56, p = 1). The linear mixed effect model showed a significant interaction between time and anti-VEGF drugs for MBR in both the ONH and Ch (ONH: p = 0.04; Ch: p = 0.002). A post hoc pairwise comparison of estimated marginal means showed that MBR decreased significantly only after IVBr (p < 0.001). CONCLUSION: Our findings suggest that the short-term impact on OBF varies depending on the drug used for nAMD.

  10. Author Correction: Reduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma. International-journal

    Kota Sato, Daisuke Saigusa, Taiki Kokubun, Amane Fujioka, Qiwei Feng, Ritsumi Saito, Akira Uruno, Naomi Matsukawa, Michiko Ohno-Oishi, Hiroshi Kunikata, Yu Yokoyama, Masayuki Yasuda, Noriko Himori, Kazuko Omodaka, Satoru Tsuda, Shigeto Maekawa, Masayuki Yamamoto, Toru Nakazawa

    npj aging　10　(1)　8-8　2024/01/20

    DOI： 10.1038/s41514-024-00137-5 　

  11. The Relationship Between Artificial Intelligence-Assisted OCT Angiography-Derived Foveal Avascular Zone Parameters and Visual-Field Defect Progression in Eyes with Open-Angle Glaucoma. International-journal

    Takahiro Ninomiya, Naoki Kiyota, Parmanand Sharma, Kazuko Omodaka, Noriko Himori, Masayuki Yasuda, Hiroshi Kunikata, Toru Nakazawa

    Ophthalmology science　4　(2)　100387-100387　2024

    DOI： 10.1016/j.xops.2023.100387 　

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    PURPOSE: To investigate clinical factors associated with foveal avascular zone (FAZ) parameters obtained using OCT angiography (OCTA) with assistance from a previously developed artificial intelligence (AI) platform in eyes with open-angle glaucoma (OAG). DESIGN: Retrospective longitudinal. PARTICIPANTS: This study followed up 885 eyes of 558 patients with OAG for ≥ 2 years; all eyes underwent ≥ 5 Humphrey visual-field (VF) tests and had 3.0 × 3.0 mm macular OCTA scans available. METHODS: Average total deviation (TD) in the superior, superocentral, inferocentral, and inferior sectors of the Humphrey 24-2 program was calculated. We collected 3.0 × 3.0 mm macular OCTA images from each patient and used a previously developed AI platform with these images to obtain FAZ parameters, including FAZ area, FAZ circularity index (CI), and FAZ perimeter. Multivariable linear mixed-effects models were used to analyze the relationship between FAZ parameters, TD or TD slope in each quadrant, and systemic factors, adjusting for potential confounding factors, including axial length. MAIN OUTCOME MEASURES: Ophthalmic and systemic variables, FAZ parameters, and TD or TD slope in each quadrant. RESULTS: The multivariable model showed that FAZ parameters were correlated with both TD and TD slope in the inferocentral quadrant (β = -0.244 - 0.168, P < 0.001). Both upper-half and lower-half FAZ parameters were better associated with TD-inferocentral and TD-inferocentral slope than TD-superocentral or TD-superocentral slope in terms of β size and statistical significance, indicating that there was no evident vertical anatomical correspondence between TD in the central quadrant and FAZ parameters. Foveal avascular zone area enlargement was associated with female gender (β = 0.242, P = 0.003). Loss of FAZ circularity was associated with both aging and comorbid sleep apnea syndrome (SAS) (yes: 1, no: 0) (β = -0.188, P < 0.001; β = -0.261, P = 0.031, respectively). Foveal avascular zone perimeter elongation was associated with aging and female gender (β = 0.084, P = 0.040; β = 0.168, P = 0.042, respectively). CONCLUSIONS: Artificial intelligence-assisted OCTA-measured FAZ enlargement and irregular shape might be good markers of ocular hypoperfusion and associated inferocentral VF defect progression in eyes with OAG. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

  12. Baseline characteristics associated with the incidence of intraocular inflammation after the intravitreous injection of brolucizumab. International-journal

    Keisuke Hoshi, Hiroshi Kunikata, Naoko Aizawa, Masayuki Yasuda, Tatsu Okabe, Hiroki Takizawa, Toshiaki Abe, Toru Nakazawa

    International ophthalmology　43　(12)　4701-4709　2023/12

    DOI： 10.1007/s10792-023-02870-4 　

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    PURPOSE: To investigate baseline characteristics associated with the incidence of intraocular inflammation (IOI) after the intravitreal injection of brolucizumab (IVBr) for the treatment of neovascular age-related macular degeneration (nAMD). METHODS: This retrospective study included 66 eyes of 62 consecutive patients with nAMD who received IVBr (18 eyes were treatment naïve and 48 eyes had switched from other anti-vascular endothelial growth factor [VEGF] therapy). Baseline clinical characteristics were compared in non-IOI and IOI groups. RESULTS: Although a dry macula was achieved at a high rate even 6 months after IVBr, IOI occurred in 8 of 66 eyes (12.1%; all had switched therapy) during the study period. Baseline characteristics including age, sex, nAMD type, lens status, visual acuity, central macular thickness, and a history of diabetes did not differ between the groups. The number of previous anti-VEGF injections before IVBr was greater in the IOI group (P = 0.004), and the ratio of patients with a laser flare-cell photometry (LFCP) value over 15 photon count per millisecond (pc/ms) was higher in the IOI group (P = 0.017). Multivariate logistic regression analysis showed that a greater number of previous anti-VEGF injections (odds ratio [OR]: 1.12, P = 0.006; area under the curve: 0.82, cut-off score: 14.0) and an LFCP value over 15 pc/ms (OR: 81.6, P = 0.031) were significantly associated with the incidence of IOI after IVBr. CONCLUSION: A number of previous anti-VEGF injections greater than 14 and an LFCP value more than 15 pc/ms might be useful predictors of the incidence of IOI after IVBr in eyes with nAMD.

  13. Reduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma. International-journal

    Kota Sato, Daisuke Saigusa, Taiki Kokubun, Amane Fujioka, Qiwei Feng, Ritsumi Saito, Akira Uruno, Naomi Matsukawa, Michiko Ohno-Oishi, Hiroshi Kunikata, Yu Yokoyama, Masayuki Yasuda, Noriko Himori, Kazuko Omodaka, Satoru Tsuda, Shigeto Maekawa, Masayuki Yamamoto, Toru Nakazawa

    npj aging　9　(1)　28-28　2023/11/21

    DOI： 10.1038/s41514-023-00124-2 　

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    Glaucoma is a leading cause of blindness worldwide in older people. Profiling the aqueous humor, including the metabolites it contains, is useful to understand physiological and pathological conditions in the eye. In the current study, we used mass spectrometry (MS) to characterize the aqueous humor metabolomic profile and biological features of patients with glaucoma. Aqueous humor samples were collected during trabeculectomy surgery or cataract surgery and analyzed with global metabolomics. We included 40 patients with glaucoma (32 with POAG, 8 with NTG) and 37 control subjects in a discovery study. VIP analysis revealed five metabolites that were elevated and three metabolites that were reduced in the glaucoma patients. The identified metabolomic profile had an area under the receiver operating characteristic curve of 0.953. Among eight selected metabolites, the glutathione level was significantly decreased in association with visual field defects. Moreover, in a validation study to confirm the reproducibility of our findings, the glutathione level was reduced in NTG and POAG patients compared with a cataract control group. Our findings demonstrate that aqueous humor profiling can help to diagnose glaucoma and that various aqueous humor metabolites are correlated with clinical parameters in glaucoma patients. In addition, glutathione is clearly reduced in the aqueous humor of glaucoma patients with both IOP-dependent and IOP-independent disease subtypes. These findings indicate that antioxidant agents in the aqueous humor reflect glaucomatous optic nerve damage and that excessive oxidative stress may be involved in the pathogenesis of glaucoma.

  14. Relationship between nailfold capillaroscopy parameters and the severity of diabetic retinopathy. International-journal

    Tatsu Okabe, Hiroshi Kunikata, Masayuki Yasuda, Shinjiro Kodama, Yuta Maeda, Joe Nakano, Dan Takeno, Nobuo Fuse, Toru Nakazawa

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie　2023/10/24

    DOI： 10.1007/s00417-023-06220-z 　

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    PURPOSE: To determine whether non-invasive measurements of the nailfold capillaries (NCs) are associated with the presence and severity of diabetic retinopathy (DR) in patients with type 2 diabetes. METHODS: Eighty-three eyes of 83 patients with type 2 diabetes were enrolled. Sixty-three age-matched non-diabetic subjects served as controls. Diabetic patients were classified by the severity of their DR: non-DR (NDR), non-proliferative DR (NPDR), and proliferative DR (PDR). We used nailfold capillaroscopy to measure NC parameters, including number, length, width, and turbidity. RESULTS: Four NC parameters in the diabetic patients were significantly lower than in the controls (all P < 0.001). There was a statistically significant decrease in the NC parameters along with the increasing severity of DR (number: P = 0.02; all others: P < 0.001). Logistic regression analysis revealed that combining the systemic characteristics of age, sex, systolic blood pressure, estimated glomerular filtration rate, hemoglobin A1c level, and history of hypertension and dyslipidemia could indicate the presence of DR and PDR (the area under the receiver operating characteristic curve [AUC] = 0.81, P = 0.006; AUC = 0.87, P = 0.001, respectively). Furthermore, the discriminative power of DR was significantly improved (P = 0.03) by adding NC length to the systemic findings (AUC = 0.89, P < 0.001). CONCLUSION: NC measurement is a simple and non-invasive way to assess the risk of DR and its severity.

  15. 近視性脈絡膜新生血管と血中潜在的抗酸化能の関連

    王 紀英, 安田 正幸, 國方 彦志, 岡部 達, 星 佳佑, 瀧澤 廣輝, 中澤 徹

    日本眼科学会雑誌　127　(臨増)　213-213　2023/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  16. Sex differences in the association between systemic oxidative stress status and optic nerve head blood flow in normal-tension glaucoma. International-journal

    Masataka Sato, Masayuki Yasuda, Nana Takahashi, Kazuki Hashimoto, Noriko Himori, Toru Nakazawa

    PloS one　18　(2)　e0282047　2023

    DOI： 10.1371/journal.pone.0282047 　

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    PURPOSE: To investigate the association of systemic oxidative stress markers and optic nerve head (ONH) blood flow in normal-tension glaucoma (NTG) patients, as well as sex differences in this association. METHODS: This was a cross-sectional study of 235 eyes with NTG of 134 patients (56 male, 78 female; mean age, 60.9±14.1 years). Laser speckle flowgraphy (LSFG) was used to measure ONH blood flow (mean blur rate in the tissue area of the ONH; MBR-T) and LSFG pulse-waveform parameters, including flow acceleration index in the tissue area of the ONH (FAI-T). Oxidative stress markers, diacron-reactive oxygen metabolites (d-ROMs), and biological antioxidant potential (BAP) were measured with a free radical elective evaluator. Spearman's rank correlation test and a multivariate linear mixed-effect model were used to investigate factors associated with ONH blood flow. RESULTS: MBR-T was significantly correlated with age (rs = -0.28, p < 0.001), mean arterial pressure (rs = -0.20, p = 0.002), intraocular pressure (rs = 0.24, p < 0.001), peripapillary retinal nerve fiber layer thickness (rs = 0.62, p < 0.001), and disc area (rs = -0.26, p < 0.001), but not with serum d-ROM level. Separate analyses of the subjects divided by sex showed that BAP was positively correlated to MBR-T (rs = 0.21, p = 0.036) and FAI-T (rs = 0.36, p < 0.001) only in male subjects. Similarly, BAP was significantly associated with MBR-T (β = 0.25, p = 0.026) and FAI-T (β = 0.37, p < 0.001) in male subjects in a multivariate linear mixed-effect model. CONCLUSION: A lower serum antioxidant level, as indicated by BAP, was associated with reduced ONH blood flow only in male NTG patients. Our findings suggest that there are sex differences in the involvement of oxidative stress in the pathogenesis of reduced ocular blood flow in NTG.

  17. Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

    Thomas W. Winkler, Humaira Rasheed, Alexander Teumer, Mathias Gorski, Bryce X. Rowan, Kira J. Stanzick, Laurent F. Thomas, Adrienne Tin, Anselm Hoppmann, Audrey Y. Chu, Bamidele Tayo, Chris H. L. Thio, Daniele Cusi, Jin-Fang Chai, Karsten B. Sieber, Katrin Horn, Man Li, Markus Scholz, Massimiliano Cocca, Matthias Wuttke, Peter J. van der Most, Qiong Yang, Sahar Ghasemi, Teresa Nutile, Yong Li, Giulia Pontali, Felix Günther, Abbas Dehghan, Adolfo Correa, Afshin Parsa, Agnese Feresin, Aiko P. J. de Vries, Alan B. Zonderman, Albert V. Smith, Albertine J. Oldehinkel, Alessandro De Grandi, Alexander R. Rosenkranz, Andre Franke, Andrej Teren, Andres Metspalu, Andrew A. Hicks, Andrew P. Morris, Anke Tönjes, Anna Morgan, Anna I. Podgornaia, Annette Peters, Antje Körner, Anubha Mahajan, Archie Campbell, Barry I. Freedman, Beatrice Spedicati, Belen Ponte, Ben Schöttker, Ben Brumpton, Bernhard Banas, Bernhard K. Krämer, Bettina Jung, Bjørn Olav Åsvold, Blair H. Smith, Boting Ning, Brenda W. J. H. Penninx, Brett R. Vanderwerff, Bruce M. Psaty, Candace M. Kammerer, Carl D. Langefeld, Caroline Hayward, Cassandra N. Spracklen, Cassianne Robinson-Cohen, Catharina A. Hartman, Cecilia M. Lindgren, Chaolong Wang, Charumathi Sabanayagam, Chew-Kiat Heng, Chiara Lanzani, Chiea-Chuen Khor, Ching-Yu Cheng, Christian Fuchsberger, Christian Gieger, Christian M. Shaffer, Christina-Alexandra Schulz, Cristen J. Willer, Daniel I. Chasman, Daniel F. Gudbjartsson, Daniela Ruggiero, Daniela Toniolo, Darina Czamara, David J. Porteous, Dawn M. Waterworth, Deborah Mascalzoni, Dennis O. Mook-Kanamori, Dermot F. Reilly, E. Warwick Daw, Edith Hofer, Eric Boerwinkle, Erika Salvi, Erwin P. Bottinger, E-Shyong Tai, Eulalia Catamo, Federica Rizzi, Feng Guo, Fernando Rivadeneira, Franco Guilianini, Gardar Sveinbjornsson, Georg Ehret, Gerard Waeber, Ginevra Biino, Giorgia Girotto, Giorgio Pistis, Girish N. Nadkarni, Graciela E. Delgado, Grant W. Montgomery, Harold Snieder, Harry Campbell, Harvey D. White, He Gao, Heather M. Stringham, Helena Schmidt, Hengtong Li, Hermann Brenner, Hilma Holm, Holgen Kirsten, Holly Kramer, Igor Rudan, Ilja M. Nolte, Ioanna Tzoulaki, Isleifur Olafsson, Jade Martins, James P. Cook, James F. Wilson, Jan Halbritter, Janine F. Felix, Jasmin Divers, Jaspal S. Kooner, Jeannette Jen-Mai Lee, Jeffrey O’Connell, Jerome I. Rotter, Jianjun Liu, Jie Xu, Joachim Thiery, Johan Ärnlöv, Johanna Kuusisto, Johanna Jakobsdottir, Johanne Tremblay, John C. Chambers, John B. Whitfield, John M. Gaziano, Jonathan Marten, Josef Coresh, Jost B. Jonas, Josyf C. Mychaleckyj, Kaare Christensen, Kai-Uwe Eckardt, Karen L. Mohlke, Karlhans Endlich, Katalin Dittrich, Kathleen A. Ryan, Kenneth M. Rice, Kent D. Taylor, Kevin Ho, Kjell Nikus, Koichi Matsuda, Konstantin Strauch, Kozeta Miliku, Kristian Hveem, Lars Lind, Lars Wallentin, Laura M. Yerges-Armstrong, Laura M. Raffield, Lawrence S. Phillips, Lenore J. Launer, Leo-Pekka Lyytikäinen, Leslie A. Lange, Lorena Citterio, Lucija Klaric, M. Arfan Ikram, Marcus Ising, Marcus E. Kleber, Margherita Francescatto, Maria Pina Concas, Marina Ciullo, Mario Piratsu, Marju Orho-Melander, Markku Laakso, Markus Loeffler, Markus Perola, Martin H. de Borst, Martin Gögele, Martina La Bianca, Mary Ann Lukas, Mary F. Feitosa, Mary L. Biggs, Mary K. Wojczynski, Maryam Kavousi, Masahiro Kanai, Masato Akiyama, Masayuki Yasuda, Matthias Nauck, Melanie Waldenberger, Miao-Li Chee, Miao-Ling Chee, Michael Boehnke, Michael H. Preuss, Michael Stumvoll, Michael A. Province, Michele K. Evans, Michelle L. O’Donoghue, Michiaki Kubo, Mika Kähönen, Mika Kastarinen, Mike A. Nalls, Mikko Kuokkanen, Mohsen Ghanbari, Murielle Bochud, Navya Shilpa Josyula, Nicholas G. Martin, Nicholas Y. Q. Tan, Nicholette D. Palmer, Nicola Pirastu, Nicole Schupf, Niek Verweij, Nina Hutri-Kähönen, Nina Mononen, Nisha Bansal, Olivier Devuyst, Olle Melander, Olli T. Raitakari, Ozren Polasek, Paolo Manunta, Paolo Gasparini, Pashupati P. Mishra, Patrick Sulem, Patrik K. E. Magnusson, Paul Elliott, Paul M. Ridker, Pavel Hamet, Per O. Svensson, Peter K. Joshi, Peter Kovacs, Peter P. Pramstaller, Peter Rossing, Peter Vollenweider, Pim van der Harst, Rajkumar Dorajoo, Ralene Z. H. Sim, Ralph Burkhardt, Ran Tao, Raymond Noordam, Reedik Mägi, Reinhold Schmidt, Renée de Mutsert, Rico Rueedi, Rob M. van Dam, Robert J. Carroll, Ron T. Gansevoort, Ruth J. F. Loos, Sala Cinzia Felicita, Sanaz Sedaghat, Sandosh Padmanabhan, Sandra Freitag-Wolf, Sarah A. Pendergrass, Sarah E. Graham, Scott D. Gordon, Shih-Jen Hwang, Shona M. Kerr, Simona Vaccargiu, Snehal B. Patil, Stein Hallan, Stephan J. L. Bakker, Su-Chi Lim, Susanne Lucae, Suzanne Vogelezang, Sven Bergmann, Tanguy Corre, Tarunveer S. Ahluwalia, Terho Lehtimäki, Thibaud S. Boutin, Thomas Meitinger, Tien-Yin Wong, Tobias Bergler, Ton J. Rabelink, Tõnu Esko, Toomas Haller, Unnur Thorsteinsdottir, Uwe Völker, Valencia Hui Xian Foo, Veikko Salomaa, Veronique Vitart, Vilmantas Giedraitis, Vilmundur Gudnason, Vincent W. V. Jaddoe, Wei Huang, Weihua Zhang, Wen Bin Wei, Wieland Kiess, Winfried März, Wolfgang Koenig, Wolfgang Lieb, Xin Gao, Xueling Sim, Ya Xing Wang, Yechiel Friedlander, Yih-Chung Tham, Yoichiro Kamatani, Yukinori Okada, Yuri Milaneschi, Zhi Yu, Chris H. L. Thio, Peter J. van der Most, Martin H. de Borst, Kevin Ho, Navya Shilpa Josyula, Sarah A. Pendergrass, Bryce X. Rowan, Cassianne Robinson-Cohen, John M. Gaziano, Lawrence S. Phillips, Ran Tao, Adriana M. Hung, Klaus J. Stark, Kari Stefansson, Carsten A. Böger, Adriana M. Hung, Florian Kronenberg, Anna Köttgen, Cristian Pattaro, Iris M. Heid

    Communications Biology　5　(1)　2022/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s42003-022-03448-z 　

    eISSN： 2399-3642

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    Abstract Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (nDM = 178,691, nnoDM = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.

  18. 近視性脈絡膜新生血管と全身酸化ストレスマーカーの関連

    王 紀英, 安田 正幸, 國方 彦志, 岡部 達, 星 佳佑, 滝澤 廣輝, 中澤 徹

    日本眼科学会雑誌　126　(臨増)　280-280　2022/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  19. 滲出型加齢黄斑変性に対するブロルシズマブ投与前後の眼血流評価

    瀧澤 廣輝, 安田 正幸, 國方 彦志, 王 英紀, 星 佳佑, 岡部 達, 新田 文彦, 阿部 俊明, 中澤 徹

    日本眼科学会雑誌　126　(臨増)　187-187　2022/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  20. 糖代謝異常者における爪床毛細血管と黄斑部毛細血管の関連

    岡部 達, 安田 正幸, 國方 彦志, 高田 菜生子, 瀧澤 廣輝, 前川 重人, 前田 雄大, 中野 譲, 武野 團, 中澤 徹

    日本眼科学会雑誌　126　(臨増)　208-208　2022/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  21. 近視性脈絡膜新生血管と全身酸化ストレスマーカーの関連

    王 紀英, 安田 正幸, 國方 彦志, 岡部 達, 星 佳佑, 滝澤 廣輝, 中澤 徹

    日本眼科学会雑誌　126　(臨増)　280-280　2022/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  22. メタボローム解析による糖尿病網膜症のバイオマーカーの探索

    安田 正幸, 國方 彦志, 児玉 慎二郎, 岡部 達, 菱沼 英史, 瀧澤 廣輝, 片桐 秀樹, 小柴 生造, 中澤 徹

    日本眼科学会雑誌　126　(臨増)　168-168　2022/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  23. CHOP deletion and anti-neuroinflammation treatment with hesperidin synergistically attenuate NMDA retinal injury in mice. International-journal

    Kota Sato, Taimu Sato, Michiko Ohno-Oishi, Mikako Ozawa, Shigeto Maekawa, Yukihiro Shiga, Takeshi Yabana, Masayuki Yasuda, Noriko Himori, Kazuko Omodaka, Kosuke Fujita, Koji M Nishiguchi, Shi Ge, Toru Nakazawa

    Experimental eye research　213　108826-108826　2021/12

    DOI： 10.1016/j.exer.2021.108826 　

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    Glaucoma is a leading cause of blindness worldwide and is characterized by degeneration associated with the death of retinal ganglion cells (RGCs). It is believed that glaucoma is a group of heterogeneous diseases with multifactorial pathomechanisms. Here, we investigate whether anti-inflammation treatment with an ER stress blockade can selectively promote neuroprotection against NMDA injury in the RGCs. Retinal excitotoxicity was induced with an intravitreal NMDA injection. Microglial activation and neuroinflammation were evaluated with Iba1 immunostaining and cytokine gene expression. A stable HT22 cell line transfected with an NF-kB reporter was used to assess NF-kB activity after hesperidin treatment. CHOP-deficient mice were used as a model of ER stress blockade. Retinal cell death was evaluated with a TUNEL assay. As results, in the NMDA injury group, Iba1-positive microglia increased 6 h after NMDA injection. Also at 6 h, pro-inflammatory cytokines and chemokine increased, including TNFα, IL-1b, IL-6 and MCP-1. In addition, the MCP-1 promoter-driven EGFP signal, which we previously identified as a stress signal in injured RGCs, also increased; hesperidin treatment suppressed this inflammatory response and reduced stressed RGCs. In CHOP-deficient mice that received an NMDA injection, the gene expression of pro-inflammatory cytokines, chemokines, markers of active microglia, and inflammatory regulators was greater than in WT mice. In WT mice, hesperidin treatment partially prevented retinal cell death after NMDA injury; this neuroprotective effect was enhanced in CHOP-deficient mice. These findings demonstrate that ER stress blockade is not enough by itself to prevent RGC loss due to neuroinflammation in the retina, but it has a synergistic neuroprotective effect after NMDA injury when combined with an anti-inflammatory treatment based on hesperidin.

  24. 糖尿病における体成分組成と眼血流の関連

    安田 正幸, 國方 彦志, 伊藤 梓, 岡部 達, 黒澤 聡子, 土屋 暁子, 澤田 正二郎, 片桐 秀樹, 中澤 徹

    眼科臨床紀要　14　(10)　692-692　2021/10

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  25. 糖尿病における体成分組成と眼血流の関連

    安田 正幸, 國方 彦志, 伊藤 梓, 岡部 達, 黒澤 聡子, 土屋 暁子, 澤田 正二郎, 片桐 秀樹, 中澤 徹

    眼科臨床紀要　14　(10)　692-692　2021/10

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  26. 正常眼圧緑内障患者における酸化ストレスマーカーと視神経乳頭血流の関連

    佐藤 正隆, 安田 正幸, 高橋 成奈, 橋本 和軌, 檜森 紀子, 中澤 徹

    日本緑内障学会抄録集　32回　80-80　2021/09

    Publisher: 日本緑内障学会

  27. 正常眼圧緑内障における血中エンドセリン濃度とFlammer症候群および視野進行の関連

    高橋 成奈, 佐藤 孝太, 高田 菜生子, 志賀 由己浩, 清田 直樹, 安田 正幸, 津田 聡, 面高 宗子, 中澤 徹

    日本緑内障学会抄録集　32回　80-80　2021/09

    Publisher: 日本緑内障学会

  28. 正常眼圧緑内障患者における酸化ストレスマーカーと視神経乳頭血流の関連

    佐藤 正隆, 安田 正幸, 高橋 成奈, 橋本 和軌, 檜森 紀子, 中澤 徹

    日本緑内障学会抄録集　32回　80-80　2021/09

    Publisher: 日本緑内障学会

  29. 正常眼圧緑内障における血中エンドセリン濃度とFlammer症候群および視野進行の関連

    高橋 成奈, 佐藤 孝太, 高田 菜生子, 志賀 由己浩, 清田 直樹, 安田 正幸, 津田 聡, 面高 宗子, 中澤 徹

    日本緑内障学会抄録集　32回　80-80　2021/09

    Publisher: 日本緑内障学会

  30. Polypoidal choroidal vasculopathy in a case of retinitis pigmentosa, successfully treated with intravitreal aflibercept. International-journal

    Nana Takahashi, Hiroshi Kunikata, Masayuki Yasuda, Takehiro Hariya, Koji M Nishiguchi, Toru Nakazawa

    American journal of ophthalmology case reports　23　101123-101123　2021/09

    DOI： 10.1016/j.ajoc.2021.101123 　

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    Purpose: Polypoidal choroidal vasculopathy (PCV) is a subtype of age-related macular degeneration that is seen frequently in Asians. Nevertheless, it is rare for this condition to be combined with retinitis pigmentosa (RP). The purpose of this paper is to present findings from this rare combination in a Japanese patient, and to describe its successful treatment with intravitreal aflibercept (IVA). Observations: The patient was a 71-year-old Japanese woman with RP (diagnosed at the age of 30) and PCV. She noticed a decrease in vision in her right eye 6 months previously. Decimal best-corrected visual acuity (BCVA) was 0.05 in her right eye. Optical coherence tomography and indocyanine green angiography (IA) revealed serous retinal detachment (SRD) and PCV in her right eye. The SRD was initially resolved after 3 monthly treatments with IVA, but recurrences began 5 months later, requiring four more treatments with IVA, performed about every 4 months within the next 12 months, for successful resolution. There were no recurrences of PCV in 7 more months of follow-up, as confirmed with IA at the final appointment. Final decimal BCVA in the right eye improved to 0.15. Furthermore, macular retinal sensitivity, measured with microperimetry, increased after the treatment, and RP-related visual field narrowing, determined by Goldmann perimetry, did not progress throughout follow up of 26 months. Conclusion: More than 2 years of follow up showed that IVA may be effective for treating PCV, even in RP patients, and can increase central visual function without causing progression of RP-related visual field narrowing.

  31. 爪床毛細血管パラメータと増殖糖尿病網膜症の関連

    岡部 達, 安田 正幸, 國方 彦志, 武野 團, 中澤 徹

    日本眼科学会雑誌　125　(臨増)　197-197　2021/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  32. 正常眼圧緑内障におけるFlammer症候群と血流因子の関連

    高橋 成奈, 志賀 由己浩, 清田 直樹, 安田 正幸, 面高 宗子, 檜森 紀子, 中澤 徹

    日本眼科学会雑誌　125　(臨増)　217-217　2021/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  33. Ocular microcirculation changes, measured with laser speckle flowgraphy and optical coherence tomography angiography, in branch retinal vein occlusion with macular edema treated by ranibizumab. International-journal

    Toshifumi Asano, Hiroshi Kunikata, Masayuki Yasuda, Koji M Nishiguchi, Toshiaki Abe, Toru Nakazawa

    International ophthalmology　41　(1)　151-162　2021/01

    DOI： 10.1007/s10792-020-01562-7 　

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    PURPOSE: This study searched for early predictive vascular biomarkers for visual outcomes in eyes with macular edema caused by branch retinal vein occlusion (BRVOME). METHODS: Twenty-four eyes of 24 subjects with BRVOME were treated with the intravitreal injection of ranibizumab (IVR) for at least 6 months. We measured mean blur rate (MBR) in the optic nerve head (ONH) and vessel density (VD) in the macula with laser speckle flowgraphy and optical coherence tomography angiography, respectively. RESULTS: Six-month post-IVR best-corrected visual acuity (BCVA) was correlated positively with age, pre-IVR BCVA, 1-month post-IVR BCVA, 3-month post-IVR BCVA and pre-IVR systolic blood pressure (P < 0.001, P < 0.001, P < 0.001, P < 0.001 and P = 0.02, respectively) and negatively with pre-IVR overall MBR, 1-month post-IVR overall MBR, 6-month post-IVR overall MBR, 3-month post-IVR deep retinal capillary plexus (DCP) VD and 6-month post-IVR DCP VD (P = 0.03, P = 0.03, P = 0.02, P = 0.01 and P = 0.005, respectively). Furthermore, a multiple regression analysis showed that pre-IVR overall MBR (β =  - 0.67, P = 0.009) was among independent prognostic factors predicting 6-month post-IVR BCVA. Six-month post-IVR DCP VD was also correlated with overall MBR at all time points. CONCLUSION: ONH blood flow may be a pre-IVR biomarker of both visual outcomes and post-IVR deep macular microcirculation in eyes with BRVOME.

  34. RETINAL SENSITIVITY AND VESSEL DENSITY AFTER MACULAR HOLE SURGERY WITH THE SUPERIOR INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE. International-journal Peer-reviewed

    Hiroshi Kunikata, Masayuki Yasuda, Naoko Aizawa, Urara Osada, Koji M Nishiguchi, Toshiaki Abe, Toru Nakazawa

    Retina (Philadelphia, Pa.)　41　(1)　45-53　2021/01/01

    DOI： 10.1097/IAE.0000000000002839 　

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    PURPOSE: To evaluate retinal vessel density and retinal sensitivity (RS) after macular hole surgery with the superior inverted internal limiting membrane flap technique. METHODS: Retrospective, observational case series. Twenty-one patients with idiopathic macular hole underwent 27-gauge vitrectomy with the superior inverted internal limiting membrane flap technique and triamcinolone acetonide. Measurements included RS, which was measured with microperimetry, as well as retinal vessel density in the superficial capillary plexus (SCP) and deep capillary plexus (DCP), which was measured with optical coherence tomography angiography. All parameters were evaluated in the superior and inferior sectors of the macula preoperatively and 1, 3, and 6 months postoperatively. RESULTS: Six months postoperatively, retinal thickness in the inferior sector was unchanged, but retinal thickness in the superior sector decreased significantly (P < 0.01). SCP vessel density in both sectors was unchanged at all postoperative time points. DCP vessel density in both sectors increased very significantly at 3 months (P < 0.01) and returned to baseline at 6 months. RS in the inferior sector increased by 47% 3 months postoperatively and by 61% 6 months postoperatively (P < 0.05 and P < 0.001, respectively), but RS in the superior sector increased only at 6 months postoperatively and only by 22% (P < 0.05). CONCLUSION: Lower recovery of RS in the superior sector suggests that internal limiting membrane peeling might affect the postoperative visual function.

  35. Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline. International-journal

    Mathias Gorski, Bettina Jung, Yong Li, Pamela R Matias-Garcia, Matthias Wuttke, Stefan Coassin, Chris H L Thio, Marcus E Kleber, Thomas W Winkler, Veronika Wanner, Jin-Fang Chai, Audrey Y Chu, Massimiliano Cocca, Mary F Feitosa, Sahar Ghasemi, Anselm Hoppmann, Katrin Horn, Man Li, Teresa Nutile, Markus Scholz, Karsten B Sieber, Alexander Teumer, Adrienne Tin, Judy Wang, Bamidele O Tayo, Tarunveer S Ahluwalia, Peter Almgren, Stephan J L Bakker, Bernhard Banas, Nisha Bansal, Mary L Biggs, Eric Boerwinkle, Erwin P Bottinger, Hermann Brenner, Robert J Carroll, John Chalmers, Miao-Li Chee, Miao-Ling Chee, Ching-Yu Cheng, Josef Coresh, Martin H de Borst, Frauke Degenhardt, Kai-Uwe Eckardt, Karlhans Endlich, Andre Franke, Sandra Freitag-Wolf, Piyush Gampawar, Ron T Gansevoort, Mohsen Ghanbari, Christian Gieger, Pavel Hamet, Kevin Ho, Edith Hofer, Bernd Holleczek, Valencia Hui Xian Foo, Nina Hutri-Kähönen, Shih-Jen Hwang, M Arfan Ikram, Navya Shilpa Josyula, Mika Kähönen, Chiea-Chuen Khor, Wolfgang Koenig, Holly Kramer, Bernhard K Krämer, Brigitte Kühnel, Leslie A Lange, Terho Lehtimäki, Wolfgang Lieb, Ruth J F Loos, Mary Ann Lukas, Leo-Pekka Lyytikäinen, Christa Meisinger, Thomas Meitinger, Olle Melander, Yuri Milaneschi, Pashupati P Mishra, Nina Mononen, Josyf C Mychaleckyj, Girish N Nadkarni, Matthias Nauck, Kjell Nikus, Boting Ning, Ilja M Nolte, Michelle L O'Donoghue, Marju Orho-Melander, Sarah A Pendergrass, Brenda W J H Penninx, Michael H Preuss, Bruce M Psaty, Laura M Raffield, Olli T Raitakari, Rainer Rettig, Myriam Rheinberger, Kenneth M Rice, Alexander R Rosenkranz, Peter Rossing, Jerome I Rotter, Charumathi Sabanayagam, Helena Schmidt, Reinhold Schmidt, Ben Schöttker, Christina-Alexandra Schulz, Sanaz Sedaghat, Christian M Shaffer, Konstantin Strauch, Silke Szymczak, Kent D Taylor, Johanne Tremblay, Layal Chaker, Pim van der Harst, Peter J van der Most, Niek Verweij, Uwe Völker, Melanie Waldenberger, Lars Wallentin, Dawn M Waterworth, Harvey D White, James G Wilson, Tien-Yin Wong, Mark Woodward, Qiong Yang, Masayuki Yasuda, Laura M Yerges-Armstrong, Yan Zhang, Harold Snieder, Christoph Wanner, Carsten A Böger, Anna Köttgen, Florian Kronenberg, Cristian Pattaro, Iris M Heid

    Kidney international　2020/10/30

    DOI： 10.1016/j.kint.2020.09.030 　

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    Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m2/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m2 at follow-up among those with eGFRcrea 60 mL/min/1.73m2 or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or LARP4B. Individuals at high compared to those at low genetic risk (8-14 vs 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.

  36. 広義原発開放隅角緑内障病型とFlammer問診票スコアの関連

    高橋 成奈, 志賀 由己浩, 清田 直樹, 安田 正幸, 佐藤 茉莉華, 津田 聡, 檜森 紀子, 面高 宗子, 高山 真, 石井 正, 中澤 徹

    日本緑内障学会抄録集　31回　75-75　2020/10

    Publisher: 日本緑内障学会

  37. Association of retinal vessel density with retinal sensitivity in surgery for idiopathic epiretinal membrane. International-journal Peer-reviewed

    Urara Osada, Hiroshi Kunikata, Masayuki Yasuda, Kazuki Hashimoto, Koji M Nishiguchi, Toru Nakazawa

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie　258　(9)　1911-1920　2020/09

    DOI： 10.1007/s00417-020-04754-0 　

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    PURPOSE: The success of surgical treatment for idiopathic epiretinal membrane (ERM) is measured by postoperative best-corrected visual acuity (BCVA), metamorphopsia, and foveal retinal sensitivity (RS).This study searched for predictive biomarkers of surgical success by determining the association between foveal RS and various aspects of vessel density (VD) in the fovea of patients with ERM. METHODS: The study examined 25 eyes of 25 patients with ERM who underwent 27-gauge microincision vitrectomy surgery (MIVS). RS was measured with microperimetry (MP-3; NIDEK) at four central points in the fovea with an interpoint distance of 2°. VD was measured with SD-OCT (RS 3000; NIDEK) within the 1-mm2 square defined by the 4 RS points at various depths, including the superficial and deep retinal capillary plexus (SCP and DCP, respectively). RESULTS: Though VD did not change throughout the follow-up period, BCVA and RS significantly improved 1 and 3 months after surgery, respectively (both P < 0.0017). Postoperative RS at 6 months was positively correlated with postoperative DCP VD at 1, 3, and 6 months (r = 0.62, P = 0.001; r = 0.40, P = 0.049; r = 0.53, P = 0.007, respectively), but not with SCP VD at any time point. Multiple regression analysis confirmed that postoperative RS at 6 months was associated with postoperative DCP VD at 1 month (P = 0.03). CONCLUSION: Higher postoperative DCP VD at 1 month contributed to better postoperative foveal RS at 6 months. Early postoperative VD in the fovea might be a useful predictive biomarker of late postoperative RS in the fovea in ERM patients.

  38. The optic nerve head vasoreactive response to systemic hyperoxia and visual field defect progression in open-angle glaucoma, a pilot study. International-journal Peer-reviewed

    Naoki Kiyota, Yukihiro Shiga, Masayuki Yasuda, Naoko Aizawa, Kazuko Omodaka, Satoru Tsuda, Kyongsun Pak, Hiroshi Kunikata, Toru Nakazawa

    Acta ophthalmologica　98　(6)　e747-e753　2020/09

    DOI： 10.1111/aos.14361 　

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    PURPOSE: To investigate the effect of optic nerve head (ONH) tissue vasoreactivity on glaucoma visual field defect progression. METHODS: This prospective, longitudinal study comprised 28 eyes of 16 patients with open-angle glaucoma. Baseline data were obtained from oxygen inhalation testing, including laser speckle flowgraphy measurements of tissue-area mean blur rate (MT), which represents ONH tissue blood flow, and the mean percentage change in MT (MT-change). Follow-up data were collected for at least 2 years, including at least 5 reliable visual field tests. The average total deviation (TD) was calculated in each sector of the Garway-Heath map; in this study, superior, central and inferior TD corresponded to inferior, temporal and superior MT or MT-change, respectively. MT and MT-change in three sectors per eye were included as explanatory variables in a multivariable linear mixed-effects model, with TD slope set as the response variable. RESULTS: At baseline, lower MT and higher diastolic blood pressure were associated with lower MT-change (p < 0.05). Additionally, MT-change significantly contributed to TD slope in the corresponding sectors (β = 0.41, p = 0.01). CONCLUSIONS: Weaker ONH tissue vasoreactivity to systemic hyperoxia, assessed with laser speckle flowgraphy, was associated with lower baseline ONH tissue blood flow, higher diastolic blood pressure and rapid visual field defect progression. Laser speckle flowgraphy variables during oxygen provocation testing may represent potentially useful predictive biomarkers of glaucoma progression.

  39. Vascular resistance of carotid and vertebral arteries is associated with retinal microcirculation measured by laser speckle flowgraphy in patients with type 2 diabetes mellitus. International-journal Peer-reviewed

    Shojiro Sawada, Satoko Tsuchiya, Shinjiro Kodama, Satoko Kurosawa, Akira Endo, Hiroto Sugawara, Shinichiro Hosaka, Yohei Kawana, Yoichiro Asai, Junpei Yamamoto, Yuichiro Munakata, Tomohito Izumi, Kei Takahashi, Keizo Kaneko, Junta Imai, Azusa Ito, Masayuki Yasuda, Hiroshi Kunikata, Toru Nakazawa, Hideki Katagiri

    Diabetes research and clinical practice　165　108240-108240　2020/07

    DOI： 10.1016/j.diabres.2020.108240 　

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    AIMS: Evaluation of the retinal microcirculation is key to understanding retinal vasculopathies, such as diabetic retinopathy. Laser speckle flowgraphy (LSFG) has recently enabled us to directly evaluate the vascular resistance in both retinal vessels and capillaries, non-invasively. We therefore assessed whether retinal vessel blood flow and/or the capillary microcirculation are associated with blood flow in the cervical arteries in diabetic patients without severe retinopathy. METHODS: We enrolled 110 type 2 diabetes patients, with no or mild non-proliferative diabetic retinopathy, in this prospective cross-sectional study. We measured the resistivity indices (RIs) of the retinal vessel and capillaries by LSFG and those of cervical arteries by Doppler ultrasonography, followed by analyzing associations. RESULTS: The RIs of not only the carotid but also vertebral arteries were associated with those of retinal vessel blood flow and the retinal capillary microcirculation. Multiple regression analyses revealed these associations to be independent of other explanatory variables including age and diabetes duration. CONCLUSIONS: We obtained novel and direct evidence demonstrating a close association between the retinal microcirculation and cervical artery hemodynamics in diabetic patients. These findings suggest shared mechanisms to underlie micro- and macro-angiopathies. Thus, high vascular resistance of cervical arteries may be a risk of developing retinopathy.

  40. Progression in Open-Angle Glaucoma with Myopic Disc and Blood Flow in the Optic Nerve Head and Peripapillary Chorioretinal Atrophy Zone

    Naoki Kiyota, Yukihiro Shiga, Nana Takahashi, Masayuki Yasuda, Kazuko Omodaka, Satoru Tsuda, Hiroshi Kunikata, Toru Nakazawa

    Ophthalmology Glaucoma　3　(3)　202-209　2020/05/01

    Publisher: American Academy of Ophthalmology

    DOI： 10.1016/j.ogla.2020.03.005 　

    ISSN： 2589-4196 2589-4234

  41. 乳頭周囲網脈絡膜萎縮部血流と緑内障視野障害進行の関連

    清田 直樹, 志賀 由己浩, 高橋 成奈, 安田 正幸, 面高 宗子, 津田 聡, 國方 彦志, 中澤 徹

    日本眼科学会雑誌　124　(臨増)　172-172　2020/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  42. Carotid artery intima-media thickness, HDL cholesterol levels, and gender associated with poor visual acuity in patients with branch retinal artery occlusion. International-journal

    Masayuki Yasuda, Hajime Sato, Kazuki Hashimoto, Urara Osada, Takehiro Hariya, Hiroko Nakayama, Toshifumi Asano, Noriyuki Suzuki, Tatsu Okabe, Mai Yamazaki, Megumi Uematsu, Masanori Munakata, Toru Nakazawa

    PloS one　15　(10)　e0240977　2020

    DOI： 10.1371/journal.pone.0240977 　

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    PURPOSE: To investigate factors associated with poor visual acuity (VA) in branch retinal artery occlusion (BRAO). METHODS: This was a retrospective cross-sectional study of 72 eyes with BRAO of 72 patients. For statistical comparison, we divided the patients into worse-VA (decimal VA < 0.5) and better-VA (decimal VA > = 0.5) groups. We examined the association of clinical findings, including blood biochemical test data and carotid artery ultrasound parameters, with poor VA. RESULTS: Median age, hematocrit, hemoglobin and high-density lipoprotein (HDL) differed significantly between the groups (P = 0.018, P < 0.01, P < 0.01, and P = 0.025). There was a tendency towards higher median IMT-Bmax in the worse-VA group (worse-VA vs. better-VA: 2.70 mm vs. 1.60 mm, P = 0.152). Spearman's rank correlation test revealed that logMAR VA was significantly correlated to IMT-Bmax (rs = 0.31, P < 0.01) and IMT-Cmax (rs = 0.24, P = 0.035). Furthermore, logMAR VA was significantly correlated to HDL level (rs = -0.33, P < 0.01). Multivariate logistic regression analysis revealed that IMT-Bmax (odds ratio [OR] = 2.70, P = 0.049), HDL level (OR = 0.91, P = 0.032), and female gender (OR = 15.63, P = 0.032) were independently associated with worse VA in BRAO. CONCLUSIONS: We found that increased IMT-Bmax, decreased HDL, and female sex were associated with poor VA in BRAO patients. Our findings might suggest novel risk factors for visual dysfunction in BRAO and may provide new insights into the pathomechanisms underlying BRAO.

  43. 糖尿病患者における黄斑部表層毛細血管密度と視神経乳頭血流波形パラメータの関連

    安田 正幸, 國方 彦志, 澤田 正二郎, 伊藤 梓, 佐竹 千尋, 片桐 秀樹, 中澤 徹

    眼科臨床紀要　12　(10)　772-772　2019/10

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  44. 早期糖尿病網膜症患者における浅層中心窩無血管領域と心臓足首血管指数の関連

    伊藤 梓, 國方 彦志, 澤田 正二郎, 安田 正幸, 佐竹 千尋, 片桐 秀樹, 中澤 徹

    眼科臨床紀要　12　(10)　772-772　2019/10

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  45. 糖尿病患者における黄斑部表層毛細血管密度と視神経乳頭血流波形パラメータの関連 Peer-reviewed

    安田 正幸, 國方 彦志, 澤田 正二郎, 伊藤 梓, 佐竹 千尋, 片桐 秀樹, 中澤 徹

    眼科臨床紀要　12　(10)　772-772　2019/10

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  46. 早期糖尿病網膜症患者における浅層中心窩無血管領域と心臓足首血管指数の関連 Peer-reviewed

    伊藤 梓, 國方 彦志, 澤田 正二郎, 安田 正幸, 佐竹 千尋, 片桐 秀樹, 中澤 徹

    眼科臨床紀要　12　(10)　772-772　2019/10

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  47. Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria. International-journal

    Alexander Teumer, Yong Li, Sahar Ghasemi, Bram P Prins, Matthias Wuttke, Tobias Hermle, Ayush Giri, Karsten B Sieber, Chengxiang Qiu, Holger Kirsten, Adrienne Tin, Audrey Y Chu, Nisha Bansal, Mary F Feitosa, Lihua Wang, Jin-Fang Chai, Massimiliano Cocca, Christian Fuchsberger, Mathias Gorski, Anselm Hoppmann, Katrin Horn, Man Li, Jonathan Marten, Damia Noce, Teresa Nutile, Sanaz Sedaghat, Gardar Sveinbjornsson, Bamidele O Tayo, Peter J van der Most, Yizhe Xu, Zhi Yu, Lea Gerstner, Johan Ärnlöv, Stephan J L Bakker, Daniela Baptista, Mary L Biggs, Eric Boerwinkle, Hermann Brenner, Ralph Burkhardt, Robert J Carroll, Miao-Li Chee, Miao-Ling Chee, Mengmeng Chen, Ching-Yu Cheng, James P Cook, Josef Coresh, Tanguy Corre, John Danesh, Martin H de Borst, Alessandro De Grandi, Renée de Mutsert, Aiko P J de Vries, Frauke Degenhardt, Katalin Dittrich, Jasmin Divers, Kai-Uwe Eckardt, Georg Ehret, Karlhans Endlich, Janine F Felix, Oscar H Franco, Andre Franke, Barry I Freedman, Sandra Freitag-Wolf, Ron T Gansevoort, Vilmantas Giedraitis, Martin Gögele, Franziska Grundner-Culemann, Daniel F Gudbjartsson, Vilmundur Gudnason, Pavel Hamet, Tamara B Harris, Andrew A Hicks, Hilma Holm, Valencia Hui Xian Foo, Shih-Jen Hwang, M Arfan Ikram, Erik Ingelsson, Vincent W V Jaddoe, Johanna Jakobsdottir, Navya Shilpa Josyula, Bettina Jung, Mika Kähönen, Chiea-Chuen Khor, Wieland Kiess, Wolfgang Koenig, Antje Körner, Peter Kovacs, Holly Kramer, Bernhard K Krämer, Florian Kronenberg, Leslie A Lange, Carl D Langefeld, Jeannette Jen-Mai Lee, Terho Lehtimäki, Wolfgang Lieb, Su-Chi Lim, Lars Lind, Cecilia M Lindgren, Jianjun Liu, Markus Loeffler, Leo-Pekka Lyytikäinen, Anubha Mahajan, Joseph C Maranville, Deborah Mascalzoni, Barbara McMullen, Christa Meisinger, Thomas Meitinger, Kozeta Miliku, Dennis O Mook-Kanamori, Martina Müller-Nurasyid, Josyf C Mychaleckyj, Matthias Nauck, Kjell Nikus, Boting Ning, Raymond Noordam, Jeffrey O' Connell, Isleifur Olafsson, Nicholette D Palmer, Annette Peters, Anna I Podgornaia, Belen Ponte, Tanja Poulain, Peter P Pramstaller, Ton J Rabelink, Laura M Raffield, Dermot F Reilly, Rainer Rettig, Myriam Rheinberger, Kenneth M Rice, Fernando Rivadeneira, Heiko Runz, Kathleen A Ryan, Charumathi Sabanayagam, Kai-Uwe Saum, Ben Schöttker, Christian M Shaffer, Yuan Shi, Albert V Smith, Konstantin Strauch, Michael Stumvoll, Benjamin B Sun, Silke Szymczak, E-Shyong Tai, Nicholas Y Q Tan, Kent D Taylor, Andrej Teren, Yih-Chung Tham, Joachim Thiery, Chris H L Thio, Hauke Thomsen, Unnur Thorsteinsdottir, Anke Tönjes, Johanne Tremblay, André G Uitterlinden, Pim van der Harst, Niek Verweij, Suzanne Vogelezang, Uwe Völker, Melanie Waldenberger, Chaolong Wang, Otis D Wilson, Charlene Wong, Tien-Yin Wong, Qiong Yang, Masayuki Yasuda, Shreeram Akilesh, Murielle Bochud, Carsten A Böger, Olivier Devuyst, Todd L Edwards, Kevin Ho, Andrew P Morris, Afshin Parsa, Sarah A Pendergrass, Bruce M Psaty, Jerome I Rotter, Kari Stefansson, James G Wilson, Katalin Susztak, Harold Snieder, Iris M Heid, Markus Scholz, Adam S Butterworth, Adriana M Hung, Cristian Pattaro, Anna Köttgen

    Nature communications　10　(1)　4130-4130　2019/09/11

    DOI： 10.1038/s41467-019-11576-0 　

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    Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an independent electronic medical records database (n = 192,868) reveal connections with proteinuria, hyperlipidemia, gout, and hypertension. Fine-mapping and trans-Omics analyses with gene expression in 47 tissues and plasma protein levels implicate genes potentially operating through differential expression in kidney (including TGFB1, MUC1, PRKCI, and OAF), and allow coupling of UACR associations to altered plasma OAF concentrations. Knockdown of OAF and PRKCI orthologs in Drosophila nephrocytes reduces albumin endocytosis. Silencing fly PRKCI further impairs slit diaphragm formation. These results generate a priority list of genes and pathways for translational research to reduce albuminuria.

  48. Sectoral Differences in the Association of Optic Nerve Head Blood Flow and Glaucomatous Visual Field Defect Severity and Progression. International-journal Peer-reviewed

    Naoki Kiyota, Yukihiro Shiga, Masayuki Yasuda, Naoko Aizawa, Kazuko Omodaka, Satoru Tsuda, Hiroshi Kunikata, Toru Nakazawa

    Investigative ophthalmology & visual science　60　(7)　2650-2658　2019/06/03

    DOI： 10.1167/iovs.19-27230 　

    ISSN： 0146-0404

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    Purpose: To investigate sectoral differences in the relationship between optic nerve head tissue blood flow, anatomically corresponding visual field defect severity, and future progression. Methods: This retrospective longitudinal medical chart review comprised 508 eyes of 319 open-angle glaucoma patients (mean deviation: -9.2 ± 7.0 dB), followed for an average of 4.7 ± 1.1 years; an average 11.7 ± 3.7 visual field tests were performed. Average total deviation (TD) was calculated in the superior, central, and inferior sectors of the Humphrey 24-2 program. The optic nerve head was divided to obtain inferior, temporal, and superior tissue-area mean blur rate (MT), derived from laser speckle flowgraphy. At baseline, the correlation between MT and TD was compared in anatomically corresponding sectors. We performed a multivariate analysis to determine the contribution of baseline MT to corresponding TD slope and to determine background factors influencing superior to temporal MT. We used a linear-mixed effect model for the statistical analysis. Results: At baseline, the highest β coefficients were found between MT-superior and TD-inferior, MT-temporal and TD-central, and between MT-inferior and TD-superior, in that order (β = 0.38, β = 0.27, β = 0.26, respectively). MT-superior and MT-temporal independently contributed to corresponding TD slope (P < 0.05). Male sex, high body mass index, and the prevalence of sleep apnea syndrome were contributing factors to lower superior to temporal MT (P < 0.05). Conclusions: Review of medical history, measurements of systemic variables, and laser speckle flowgraphy parameters might help clinicians to predict visual field defect severity and progression.

  49. A catalog of genetic loci associated with kidney function from analyses of a million individuals. International-journal

    Matthias Wuttke, Yong Li, Man Li, Karsten B Sieber, Mary F Feitosa, Mathias Gorski, Adrienne Tin, Lihua Wang, Audrey Y Chu, Anselm Hoppmann, Holger Kirsten, Ayush Giri, Jin-Fang Chai, Gardar Sveinbjornsson, Bamidele O Tayo, Teresa Nutile, Christian Fuchsberger, Jonathan Marten, Massimiliano Cocca, Sahar Ghasemi, Yizhe Xu, Katrin Horn, Damia Noce, Peter J van der Most, Sanaz Sedaghat, Zhi Yu, Masato Akiyama, Saima Afaq, Tarunveer S Ahluwalia, Peter Almgren, Najaf Amin, Johan Ärnlöv, Stephan J L Bakker, Nisha Bansal, Daniela Baptista, Sven Bergmann, Mary L Biggs, Ginevra Biino, Michael Boehnke, Eric Boerwinkle, Mathilde Boissel, Erwin P Bottinger, Thibaud S Boutin, Hermann Brenner, Marco Brumat, Ralph Burkhardt, Adam S Butterworth, Eric Campana, Archie Campbell, Harry Campbell, Mickaël Canouil, Robert J Carroll, Eulalia Catamo, John C Chambers, Miao-Ling Chee, Miao-Li Chee, Xu Chen, Ching-Yu Cheng, Yurong Cheng, Kaare Christensen, Renata Cifkova, Marina Ciullo, Maria Pina Concas, James P Cook, Josef Coresh, Tanguy Corre, Cinzia Felicita Sala, Daniele Cusi, John Danesh, E Warwick Daw, Martin H de Borst, Alessandro De Grandi, Renée de Mutsert, Aiko P J de Vries, Frauke Degenhardt, Graciela Delgado, Ayse Demirkan, Emanuele Di Angelantonio, Katalin Dittrich, Jasmin Divers, Rajkumar Dorajoo, Kai-Uwe Eckardt, Georg Ehret, Paul Elliott, Karlhans Endlich, Michele K Evans, Janine F Felix, Valencia Hui Xian Foo, Oscar H Franco, Andre Franke, Barry I Freedman, Sandra Freitag-Wolf, Yechiel Friedlander, Philippe Froguel, Ron T Gansevoort, He Gao, Paolo Gasparini, J Michael Gaziano, Vilmantas Giedraitis, Christian Gieger, Giorgia Girotto, Franco Giulianini, Martin Gögele, Scott D Gordon, Daniel F Gudbjartsson, Vilmundur Gudnason, Toomas Haller, Pavel Hamet, Tamara B Harris, Catharina A Hartman, Caroline Hayward, Jacklyn N Hellwege, Chew-Kiat Heng, Andrew A Hicks, Edith Hofer, Wei Huang, Nina Hutri-Kähönen, Shih-Jen Hwang, M Arfan Ikram, Olafur S Indridason, Erik Ingelsson, Marcus Ising, Vincent W V Jaddoe, Johanna Jakobsdottir, Jost B Jonas, Peter K Joshi, Navya Shilpa Josyula, Bettina Jung, Mika Kähönen, Yoichiro Kamatani, Candace M Kammerer, Masahiro Kanai, Mika Kastarinen, Shona M Kerr, Chiea-Chuen Khor, Wieland Kiess, Marcus E Kleber, Wolfgang Koenig, Jaspal S Kooner, Antje Körner, Peter Kovacs, Aldi T Kraja, Alena Krajcoviechova, Holly Kramer, Bernhard K Krämer, Florian Kronenberg, Michiaki Kubo, Brigitte Kühnel, Mikko Kuokkanen, Johanna Kuusisto, Martina La Bianca, Markku Laakso, Leslie A Lange, Carl D Langefeld, Jeannette Jen-Mai Lee, Benjamin Lehne, Terho Lehtimäki, Wolfgang Lieb, Su-Chi Lim, Lars Lind, Cecilia M Lindgren, Jun Liu, Jianjun Liu, Markus Loeffler, Ruth J F Loos, Susanne Lucae, Mary Ann Lukas, Leo-Pekka Lyytikäinen, Reedik Mägi, Patrik K E Magnusson, Anubha Mahajan, Nicholas G Martin, Jade Martins, Winfried März, Deborah Mascalzoni, Koichi Matsuda, Christa Meisinger, Thomas Meitinger, Olle Melander, Andres Metspalu, Evgenia K Mikaelsdottir, Yuri Milaneschi, Kozeta Miliku, Pashupati P Mishra, Karen L Mohlke, Nina Mononen, Grant W Montgomery, Dennis O Mook-Kanamori, Josyf C Mychaleckyj, Girish N Nadkarni, Mike A Nalls, Matthias Nauck, Kjell Nikus, Boting Ning, Ilja M Nolte, Raymond Noordam, Jeffrey O'Connell, Michelle L O'Donoghue, Isleifur Olafsson, Albertine J Oldehinkel, Marju Orho-Melander, Willem H Ouwehand, Sandosh Padmanabhan, Nicholette D Palmer, Runolfur Palsson, Brenda W J H Penninx, Thomas Perls, Markus Perola, Mario Pirastu, Nicola Pirastu, Giorgio Pistis, Anna I Podgornaia, Ozren Polasek, Belen Ponte, David J Porteous, Tanja Poulain, Peter P Pramstaller, Michael H Preuss, Bram P Prins, Michael A Province, Ton J Rabelink, Laura M Raffield, Olli T Raitakari, Dermot F Reilly, Rainer Rettig, Myriam Rheinberger, Kenneth M Rice, Paul M Ridker, Fernando Rivadeneira, Federica Rizzi, David J Roberts, Antonietta Robino, Peter Rossing, Igor Rudan, Rico Rueedi, Daniela Ruggiero, Kathleen A Ryan, Yasaman Saba, Charumathi Sabanayagam, Veikko Salomaa, Erika Salvi, Kai-Uwe Saum, Helena Schmidt, Reinhold Schmidt, Ben Schöttker, Christina-Alexandra Schulz, Nicole Schupf, Christian M Shaffer, Yuan Shi, Albert V Smith, Blair H Smith, Nicole Soranzo, Cassandra N Spracklen, Konstantin Strauch, Heather M Stringham, Michael Stumvoll, Per O Svensson, Silke Szymczak, E-Shyong Tai, Salman M Tajuddin, Nicholas Y Q Tan, Kent D Taylor, Andrej Teren, Yih-Chung Tham, Joachim Thiery, Chris H L Thio, Hauke Thomsen, Gudmar Thorleifsson, Daniela Toniolo, Anke Tönjes, Johanne Tremblay, Ioanna Tzoulaki, André G Uitterlinden, Simona Vaccargiu, Rob M van Dam, Pim van der Harst, Cornelia M van Duijn, Digna R Velez Edward, Niek Verweij, Suzanne Vogelezang, Uwe Völker, Peter Vollenweider, Gerard Waeber, Melanie Waldenberger, Lars Wallentin, Ya Xing Wang, Chaolong Wang, Dawn M Waterworth, Wen Bin Wei, Harvey White, John B Whitfield, Sarah H Wild, James F Wilson, Mary K Wojczynski, Charlene Wong, Tien-Yin Wong, Liang Xu, Qiong Yang, Masayuki Yasuda, Laura M Yerges-Armstrong, Weihua Zhang, Alan B Zonderman, Jerome I Rotter, Murielle Bochud, Bruce M Psaty, Veronique Vitart, James G Wilson, Abbas Dehghan, Afshin Parsa, Daniel I Chasman, Kevin Ho, Andrew P Morris, Olivier Devuyst, Shreeram Akilesh, Sarah A Pendergrass, Xueling Sim, Carsten A Böger, Yukinori Okada, Todd L Edwards, Harold Snieder, Kari Stefansson, Adriana M Hung, Iris M Heid, Markus Scholz, Alexander Teumer, Anna Köttgen, Cristian Pattaro

    Nature genetics　51　(6)　957-972　2019/06

    DOI： 10.1038/s41588-019-0407-x 　

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    Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these, 147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.

  50. 2型糖尿病患者におけるLaser speckle flowgraphyによる視神経乳頭領域の眼血流指標と超音波検査による頸動脈血流指標との関係

    澤田 正二郎, 佐竹 千尋, 國方 彦志, 安田 正幸, 伊藤 梓, 黒澤 聡子, 児玉 慎二郎, 山本 淳平, 金子 慶三, 今井 淳太, 中澤 徹, 片桐 秀樹

    糖尿病　62　(Suppl.1)　S-128　2019/04

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

    eISSN： 1881-588X

  51. The Relationship between Carotid Intima-Media Thickness and Ocular Circulation in Type-2 Diabetes. International-journal Peer-reviewed

    Kohei Ichinohasama, Hiroshi Kunikata, Azusa Ito, Masayuki Yasuda, Shojiro Sawada, Keiichi Kondo, Chihiro Satake, Hideki Katagiri, Toru Nakazawa

    Journal of ophthalmology　2019　3421305-3421305　2019

    DOI： 10.1155/2019/3421305 　

    ISSN： 2090-004X

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    Purpose: To compare clinical findings, including ocular blood flow and intima-media thickness (IMT) of the carotid artery, in mild nonproliferative diabetic retinopathy (NPDR) and no diabetic retinopathy (NDR) patients, and to determine risk factors contributing to mild NPDR. Methods: In 129 subjects (129 eyes) with type-2 diabetes patients and mild NPDR or NDR, standard statistical techniques were used to determine associations between clinical findings, including diabetes duration, blood levels of creatinine and hemoglobin A1c (HbA1c), central macular thickness (CMT; measured with optical coherence tomography), mean blur rate (MBR; measured with laser speckle flowgraphy), and ultrasound-measured carotid IMT. Results: Diabetes duration, IMT, and CMT were significantly higher in the mild NPDR patients than the NDR patients (P=0.004, P=0.004, and P=0.003, respectively), while conversely, MBR in the overall optic nerve head (MBR-A) was lower in the mild NPDR patients. Furthermore, a logistic regression analysis showed that diabetes duration (OR, 1.11; P=0.006), diastolic blood pressure (OR, 0.93; P=0.025), heart rate (OR, 1.07; P=0.004), IMT (OR, 8.65; P=0.005), and CMT (OR, 1.03; P=0.007) were independent contributing factors to mild NPDR. Spearman's rank correlation test also showed that IMT was negatively correlated with MBR-A (P=0.011). Conclusions: Increased IMT showed a close association with ocular ischemia in patients with type-2 diabetes and contributed to the presence of mild NPDR. These findings suggest that IMT may be an early biomarker of mild NPDR.

  52. Macular thickness profile and diabetic retinopathy: the Singapore Epidemiology of Eye Diseases Study. International-journal Peer-reviewed

    Wei Dai, Yih Chung Tham, Ning Cheung, Masayuki Yasuda, Nicholas Y Q Tan, Carol Y Cheung, Jie Jin Wang, Paul Mitchell, Charumathi Sabanayagam, Tien-Yin Wong, Ching-Yu Cheng

    The British journal of ophthalmology　102　(8)　1072-1076　2018/08

    DOI： 10.1136/bjophthalmol-2017-310959 　

    ISSN： 0007-1161

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    BACKGROUND: To evaluate retinal thickness profiles in eyes with and without diabetic retinopathy (DR) using spectral-domain optical coherence tomography (SD-OCT) among individuals with diabetes. METHODS: Participants were recruited from the Singapore Epidemiology of Eye Diseases Study, a population-based study among Chinese, Malays and Indians aged 40 years or older residing in Singapore. All participants underwent standardised systemic and ophthalmic examinations. Average thickness of the macula, ganglion cell-inner plexiform layer and outer retina layer (from the outer plexiform layer to the retinal pigment epithelium layer) were measured using SD-OCT. DR status and severity were graded based on fundus photographs using the modified Airlie House classification system. Participants with macular oedema were excluded. RESULTS: 2240 eyes from 1280 participants were included. Of these, 1764 (78.7%) eyes had no DR, 351 (15.7%) eyes had minimal or mild DR and 125 (5.6%) eyes had moderate or worse DR. After adjusting for age, gender, ethnicity, axial length, hypertension, glycated haemoglobin, body mass index, total cholesterol and diabetes duration, eyes with DR had thicker macula (245.44 µm vs 243.04 µm, P=0.03) and outer retina (124.26 µm vs 123.08 µm, P=0.01) than eyes without DR. When stratified by DR severity, thicker macula (250.24 µm vs 242.88 µm, P=0.011) and outer retina (126.4 µm vs 123.0 μm, P=0.006) were observed in eyes with moderate or worse, but not minimal or mild DR, compared with eyes without DR. CONCLUSIONS: Even in the absence of macular oedema, eyes with DR, particularly those with more severe DR, had thicker macular and outer retinal layers than eyes without DR.

  53. The Impact of Intraocular Pressure Elevation on Optic Nerve Head and Choroidal Blood Flow. International-journal Peer-reviewed

    Naoki Kiyota, Yukihiro Shiga, Kohei Ichinohasama, Masayuki Yasuda, Naoko Aizawa, Kazuko Omodaka, Naoto Honda, Hiroshi Kunikata, Toru Nakazawa

    Investigative ophthalmology & visual science　59　(8)　3488-3496　2018/07/02

    DOI： 10.1167/iovs.18-23872 　

    ISSN： 0146-0404

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    Purpose: To use laser speckle flowgraphy (LSFG) to assess blood flow (BF) in the optic nerve head (ONH) tissue and choroid during elevated intraocular pressure (IOP). Methods: This prospective study included 20 eyes of 20 healthy volunteers. The testing protocol had a baseline phase, two elevated IOP phases (+10 and +20 mm Hg), and a recovery phase. IOP was elevated by pushing against the eyelid with a novel tubular device attached to the LSFG apparatus. Measurement parameters in each phase included: LSFG-derived mean blur rate (MBR) and flow acceleration index (FAI); systemic parameters, and IOP. The % change against baseline was calculated for each phase. The protocol was repeated five times to calculate the coefficient of variation (CV) for % change MBR and to determine the effect of mydriasis on % change MBR. We compared % change MBR and FAI and evaluated the relationship between % change ocular perfusion pressure (OPP) and MBR in the choroid and ONH tissue. Results: The % change MBR was highly reproducible (CV: 6.1-8.7%) and not affected by mydriasis (P = 0.57-0.96). The % change MBR and FAI were higher in the ONH tissue than choroid during IOP elevation (P = 0.04). The % change OPP and MBR showed positive linear correlations and two-segmental linear correlations in the choroid and ONH tissue, respectively (P < 0.01). Conclusion: Hemodynamics during IOP elevation differ in the choroid and ONH tissue. LSFG enables highly reproducible assessment of the dynamic autoregulation of ocular BF in the ONH tissue.

  54. Associations of Peripapillary Atrophy and Fundus Tessellation with Diabetic Retinopathy. International-journal

    Nicholas Y Q Tan, Yih-Chung Tham, Yang Ding, Masayuki Yasuda, Charumathi Sabanayagam, Seang-Mei Saw, Jie Jin Wang, Paul Mitchell, Tien Yin Wong, Ching-Yu Cheng

    Ophthalmology. Retina　2　(6)　574-581　2018/06

    DOI： 10.1016/j.oret.2017.09.019 　

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    PURPOSE: There is a limited understanding of ocular risk factors for diabetic retinopathy (DR). Our aim therefore was to determine the relationship of 2 retinal signs related to axial myopia (peripapillary atrophy [PPA] and fundus tessellation) with DR. DESIGN: Cross-sectional study. METHODS: Of 3353 subjects (72.8% response rate) who participated in the population-based Singapore Chinese Eye Study, 592 participants had diabetes. Of these, 1010 eyes from 530 participants were included in our analyses after excluding participants without gradable retinal photographs or missing key variables. DR, PPA-beta (β), and fundus tessellation were graded from retinal photographs. The associations between PPA-β or fundus tessellation with DR were analyzed using logistic regression models with generalized estimating equations. MAIN OUTCOME MEASURES: Diabetic retinopathy. RESULTS: Among the 530 participants, the mean (standard deviation) age was 62.8 (9.2) years, and 288 (54.3%) were male. PPA-β and fundus tessellation were both associated with longer axial length (AL). In multivariable analyses adjusting for potential confounders including AL, eyes with PPA-β or fundus tessellation were less likely to have any DR, with odds ratio (95% confidence interval) 0.58 (0.41-0.83) and 0.46 (0.25-0.87), respectively. These associations with DR were consistent in models adjusting for refractive status, and in a subanalysis that excluded eyes with high AL (>24.5 mm). CONCLUSIONS: Eyes with PPA-β or fundus tessellation were less likely to have DR, independent of diabetes risk factors, AL, or refractive status. The presence of these 2 ophthalmic features may indicate lower risk of DR.

  55. Characteristic Profiles of Inflammatory Cytokines in the Aqueous Humor of Glaucomatous Eyes. International-journal Peer-reviewed

    Taiki Kokubun, Satoru Tsuda, Hiroshi Kunikata, Masayuki Yasuda, Noriko Himori, Shiho Kunimatsu-Sanuki, Kazuichi Maruyama, Toru Nakazawa

    Ocular immunology and inflammation　26　(8)　1177-1188　2018

    DOI： 10.1080/09273948.2017.1327605 　

    ISSN： 0927-3948

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    PURPOSE: To analyze cytokine profiles of the aqueous humor of eyes with primary open-angle glaucoma (POAG), neovascular glaucoma (NVG), and cataract (as controls). METHODS: A multiplex bead assay was used to measure concentrations of 27 cytokines in aqueous humor samples from 54 eyes. RESULTS: Detection rates were as follows: IL-7: NVG higher than POAG; IL-10: POAG lower than cataract or NVG; and GM-CSF: cataract higher than POAG or NVG. Concentrations were as follows: IL-8, IP-10, MCP-1, and MIP-1β: POAG and NVG higher than cataract; IL-9: POAG lower than NVG; IL-12: POAG lower than cataract or NVG; and VEGF: NVG higher than cataract or POAG and POAG lower than cataract. Further analysis showed that IL-8, IP-10, MCP-1, and MIP-1β were correlated with intraocular pressure and age. CONCLUSIONS: The detection rates and levels of various cytokines had different patterns in POAG and NVG patients, suggesting distinctive alterations in the microenvironment in different types of glaucoma.

  56. The Relationship between Peripheral Nerve Conduction Velocity and Ophthalmological Findings in Type 2 Diabetes Patients with Early Diabetic Retinopathy. International-journal Peer-reviewed

    Azusa Ito, Hiroshi Kunikata, Masayuki Yasuda, Shojiro Sawada, Keiichi Kondo, Chihiro Satake, Kazuki Hashimoto, Naoko Aizawa, Hideki Katagiri, Toru Nakazawa

    Journal of ophthalmology　2018　2439691-2439691　2018

    DOI： 10.1155/2018/2439691 　

    ISSN： 2090-004X

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    Purpose: Nerve conduction velocity (NCV) is an indicator of neuronal damage in the distal segment of the peripheral nerves. Here, we determined the association between NCV and other systemic and ocular clinical findings, in type 2 diabetes patients with early diabetic retinopathy (DR). Methods: This study included 42 eyes of 42 type 2 diabetes patients (median age: 54 years) with no DR or with mild nonproliferative DR. Standard statistical techniques were used to determine associations between clinical findings. Results: Sural sensory conduction velocity (SCV) and tibial motor conduction velocity (MCV) were significantly lower in mild nonproliferative DR patients than patients with no DR (P = 0.008 and P = 0.01, resp.). Furthermore, logistic regression analyses revealed that sural SCV and tibial MCV were independent factors contributing to the presence of mild nonproliferative DR (OR 0.83, P = 0.012 and OR 0.69 P = 0.02, resp.). Tibial MCV was correlated with choroidal thickness (CT) (P = 0.01), and a multiple regression analysis revealed that age, tibial MCV, and carotid intima-media thickness were independent associating factors with CT (P = 0.035, P = 0.015, and P = 0.008, resp.). Conclusions: Our findings suggest that reduced NCV may be closely associated with early DR in type 2 diabetes patients. Thus, reduced nerve conduction is a potential early biomarker of DR.

  57. Associations between sleep duration, sleep quality and diabetic retinopathy. International-journal Peer-reviewed

    Nicholas Y Q Tan, Merwyn Chew, Yih-Chung Tham, Quang Duc Nguyen, Masayuki Yasuda, Ching-Yu Cheng, Tien Yin Wong, Charumathi Sabanayagam

    PloS one　13　(5)　e0196399　2018

    DOI： 10.1371/journal.pone.0196399 　

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    BACKGROUND: Abnormal durations of sleep have been associated with risk of diabetes. However, it is not clear if sleep duration is associated with diabetic retinopathy (DR). METHODS: In a cross-sectional study, we included 1,231 (Malay, n = 395; Indian, n = 836) adults (mean age 64.4 ± 9.0 years, 50.4% female) with diabetes from the second visit of two independent population-based cohort studies (2011-15) in Singapore. Self-reported habitual sleep duration was categorized as short (<6 h), normal (6≤ h <8), and long (≥8 h). Questionnaires were administered to detect risk of obstructive sleep apnea (OSA), excessive daytime sleepiness, and insomnia, all of which may indicate poor quality of sleep. The associations between sleep-related characteristics with moderate DR and vision-threatening DR (VTDR) were analysed using logistic regression models adjusted for potential confounders. RESULTS: Prevalence of moderate DR and VTDR in the study population were 10.5% and 6.3% respectively. The mean duration of sleep was 6.4 ± 1.5 h. Compared to normal sleep duration, both short and long sleep durations were associated with moderate DR with multivariable odds ratio (95% confidence interval) of 1.73 (1.03-2.89) and 2.17 (1.28-3.66) respectively. Long sleep duration (2.37 [1.16-4.89]), high risk of OSA (2.24 [1.09-4.75]), and excessive daytime sleepiness (3.27 [1.02-10.30]) were separately associated with VTDR. CONCLUSION: Sleep duration had a U-shaped association with moderate DR; long sleep duration, excessive daytime sleepiness and high risk of OSA were positively associated with VTDR.

  58. The neuroprotective effect of latanoprost acts via klotho-mediated suppression of calpain activation after optic nerve transection. International-journal Peer-reviewed

    Kotaro Yamamoto, Kota Sato, Masayoshi Yukita, Masayuki Yasuda, Kazuko Omodaka, Morin Ryu, Kosuke Fujita, Koji M Nishiguchi, Shigeki Machida, Toru Nakazawa

    Journal of neurochemistry　140　(3)　495-508　2017/02

    DOI： 10.1111/jnc.13902 　

    ISSN： 0022-3042

    eISSN： 1471-4159

  59. Brimonidine Enhances the Electrophysiological Response of Retinal Ganglion Cells through the Trk-MAPK/ERK and PI3K Pathways in Axotomized Eyes. International-journal Peer-reviewed

    Masayoshi Yukita, Kazuko Omodaka, Shigeki Machida, Masayuki Yasuda, Kota Sato, Kazuichi Maruyama, Koji M Nishiguchi, Toru Nakazawa

    Current eye research　42　(1)　125-133　2017/01

    DOI： 10.3109/02713683.2016.1153112 　

    ISSN： 0271-3683

    eISSN： 1460-2202

  60. The relationship between advanced glycation end products and ocular circulation in type 2 diabetes Peer-reviewed

    Kazuki Hashimoto, Hiroshi Kunikata, Masayuki Yasuda, Azusa Ito, Naoko Aizawa, Shojiro Sawada, Keiichi Kondo, Chihiro Satake, Yoshimasa Takano, Koji M. Nishiguchi, Hideki Katagiri, Toru Nakazawa

    JOURNAL OF DIABETES AND ITS COMPLICATIONS　30　(7)　1371-1377　2016/09

    DOI： 10.1016/j.jdiacomp.2016.04.024 　

    ISSN： 1056-8727

    eISSN： 1873-460X

  61. Transcriptome profiling of the rat retina after optic nerve transection. International-journal Peer-reviewed

    Masayuki Yasuda, Yuji Tanaka, Kazuko Omodaka, Koji M Nishiguchi, Orie Nakamura, Satoru Tsuda, Toru Nakazawa

    Scientific reports　6　28736-28736　2016/06/29

    DOI： 10.1038/srep28736 　

    ISSN： 2045-2322

  62. Real-time imaging of RGC death with a cell-impermeable nucleic acid dyeing compound after optic nerve crush in a murine model. International-journal Peer-reviewed

    Satoru Tsuda, Yuji Tanaka, Hiroshi Kunikata, Yu Yokoyama, Masayuki Yasuda, Azusa Ito, Toru Nakazawa

    Experimental eye research　146　179-88　2016/05

    DOI： 10.1016/j.exer.2016.03.017 　

    ISSN： 0014-4835

    eISSN： 1096-0007

  63. In vivo cellular imaging of various stress/response pathways using AAV following axonal injury in mice. International-journal Peer-reviewed

    Kosuke Fujita, Koji M Nishiguchi, Yu Yokoyama, Yusuke Tomiyama, Satoru Tsuda, Masayuki Yasuda, Shigeto Maekawa, Toru Nakazawa

    Scientific reports　5　18141-18141　2015/12/16

    DOI： 10.1038/srep18141 　

    ISSN： 2045-2322

  64. Molecular, anatomical and functional changes in the retinal ganglion cells after optic nerve crush in mice. International-journal Peer-reviewed

    Masayoshi Yukita, Shigeki Machida, Koji M Nishiguchi, Satoru Tsuda, Yu Yokoyama, Masayuki Yasuda, Kazuichi Maruyama, Toru Nakazawa

    Documenta ophthalmologica. Advances in ophthalmology　130　(2)　149-56　2015/04

    DOI： 10.1007/s10633-014-9478-2 　

    ISSN： 0012-4486

    eISSN： 1573-2622

  65. Relationship of skin autofluorescence to severity of retinopathy in type 2 diabetes. International-journal Peer-reviewed

    Masayuki Yasuda, Masahiko Shimura, Hiroshi Kunikata, Hiroko Kanazawa, Kanako Yasuda, Yuji Tanaka, Hideyuki Konno, Mai Takahashi, Taiki Kokubun, Kazuichi Maruyama, Noriko Sato, Masako Kakizaki, Mari Sato, Ichiro Tsuji, Toshio Miyata, Toru Nakazawa

    Current eye research　40　(3)　338-45　2015/03

    DOI： 10.3109/02713683.2014.918152 　

    ISSN： 0271-3683

    eISSN： 1460-2202

  66. Pulse-waveform analysis of normal population using laser speckle flowgraphy. International-journal Peer-reviewed

    Satoru Tsuda, Hiroshi Kunikata, Masahiko Shimura, Naoko Aizawa, Kazuko Omodaka, Yukihiro Shiga, Masayuki Yasuda, Yu Yokoyama, Toru Nakazawa

    Current eye research　39　(12)　1207-15　2014/12

    DOI： 10.3109/02713683.2014.905608 　

    ISSN： 0271-3683

    eISSN： 1460-2202

  67. Artemin augments survival and axon regeneration in axotomized retinal ganglion cells. International-journal Peer-reviewed

    Kazuko Omodaka, Takuji Kurimoto, Orie Nakamura, Kota Sato, Masayuki Yasuda, Yuji Tanaka, Noriko Himori, Yu Yokoyama, Toru Nakazawa

    Journal of neuroscience research　92　(12)　1637-46　2014/12

    DOI： 10.1002/jnr.23449 　

    ISSN： 0360-4012

    eISSN： 1097-4547

  68. Retinal transcriptome profiling at transcription start sites: a cap analysis of gene expression early after axonal injury. International-journal Peer-reviewed

    Masayuki Yasuda, Yuji Tanaka, Koji M Nishiguchi, Morin Ryu, Satoru Tsuda, Kazuichi Maruyama, Toru Nakazawa

    BMC genomics　15　982-982　2014/11/18

    DOI： 10.1186/1471-2164-15-982 　

    ISSN： 1471-2164

  69. Neuroprotective effect against axonal damage-induced retinal ganglion cell death in apolipoprotein E-deficient mice through the suppression of kainate receptor signaling. International-journal Peer-reviewed

    Kazuko Omodaka, Koji M Nishiguchi, Masayuki Yasuda, Yuji Tanaka, Kota Sato, Orie Nakamura, Kazuichi Maruyama, Toru Nakazawa

    Brain research　1586　203-12　2014/10/24

    DOI： 10.1016/j.brainres.2014.08.053 　

    ISSN： 0006-8993

    eISSN： 1872-6240

  70. The role of calpain in an in vivo model of oxidative stress-induced retinal ganglion cell damage. International-journal Peer-reviewed

    Yu Yokoyama, Kazuichi Maruyama, Kotaro Yamamoto, Kazuko Omodaka, Masayuki Yasuda, Noriko Himori, Morin Ryu, Koji M Nishiguchi, Toru Nakazawa

    Biochemical and biophysical research communications　451　(4)　510-5　2014/09/05

    DOI： 10.1016/j.bbrc.2014.08.009 　

    ISSN： 0006-291X

    eISSN： 1090-2104

  71. Critical neuroprotective roles of heme oxygenase-1 induction against axonal injury-induced retinal ganglion cell death. International-journal Peer-reviewed

    Noriko Himori, Kazuichi Maruyama, Kotaro Yamamoto, Masayuki Yasuda, Morin Ryu, Kazuko Omodaka, Yukihiro Shiga, Yuji Tanaka, Toru Nakazawa

    Journal of neuroscience research　92　(9)　1134-42　2014/09

    DOI： 10.1002/jnr.23398 　

    ISSN： 0360-4012

    eISSN： 1097-4547

  72. Profiles of extracellular miRNAs in the aqueous humor of glaucoma patients assessed with a microarray system. International-journal Peer-reviewed

    Yuji Tanaka, Satoru Tsuda, Hiroshi Kunikata, Junko Sato, Taiki Kokubun, Masayuki Yasuda, Koji M Nishiguchi, Toshifumi Inada, Toru Nakazawa

    Scientific reports　4　5089-5089　2014/05/28

    DOI： 10.1038/srep05089 　

    ISSN： 2045-2322

  73. RNA sequence reveals mouse retinal transcriptome changes early after axonal injury. International-journal Peer-reviewed

    Masayuki Yasuda, Yuji Tanaka, Morin Ryu, Satoru Tsuda, Toru Nakazawa

    PloS one　9　(3)　e93258　2014

    DOI： 10.1371/journal.pone.0093258 　

    ISSN： 1932-6203

  74. The effect of intravitreal bevacizumab on ocular blood flow in diabetic retinopathy and branch retinal vein occlusion as measured by laser speckle flowgraphy. International-journal Peer-reviewed

    Fumihiko Nitta, Hiroshi Kunikata, Naoko Aizawa, Kazuko Omodaka, Yukihiro Shiga, Masayuki Yasuda, Toru Nakazawa

    Clinical ophthalmology (Auckland, N.Z.)　8　1119-27　2014

    DOI： 10.2147/OPTH.S62022 　

    ISSN： 1177-5467

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    BACKGROUND: This study evaluated the effect of intravitreal injection of bevacizumab (IVB) on macular edema associated with diabetic retinopathy (DME) or branch retinal vein occlusion (BRVOME) using laser speckle flowgraphy. METHODS: A comparative interventional study of 25 eyes from 22 patients with macular edema (DME group: 12 eyes; BRVOME group: 13 eyes) who underwent IVB. Mean blur rate (MBR) was measured in the retinal artery, retinal vein, optic nerve head (ONH), and choroid before and after IVB. RESULTS: In the BRVOME group, there was no significant change in MBR in the retinal artery, retinal vein or ONH, but choroidal MBR decreased significantly (P=0.04). In the DME group, the MBR in the retinal artery, retinal vein, ONH, and choroid decreased significantly (P=0.02, P=0.04, P<0.001, and P=0.04, respectively). In the DME group, pre-IVB MBR in the ONH was significantly correlated with post-IVB foveal thickness (R= -0.71, P=0.002). There was no such correlation in the BRVOME group in the ONH. CONCLUSION: IVB had a suppressive effect on circulation in eyes with DME but not in those with BRVOME. This suggests that this noninvasive and objective biomarker may be a useful part of pre-IVB evaluations and decision-making in DME.

  75. Intraocular concentrations of cytokines and chemokines in rhegmatogenous retinal detachment and the effect of intravitreal triamcinolone acetonide. International-journal Peer-reviewed

    Hiroshi Kunikata, Masayuki Yasuda, Naoko Aizawa, Yuji Tanaka, Toshiaki Abe, Toru Nakazawa

    American journal of ophthalmology　155　(6)　1028-1037　2013/06

    DOI： 10.1016/j.ajo.2013.01.013 　

    ISSN： 0002-9394

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    PURPOSE: To investigate the role of intravitreal injection of triamcinolone acetonide (IVTA) in preventing photoreceptor apoptosis in eyes with rhegmatogenous retinal detachment (RRD) by measuring cytokine levels in the aqueous humor before and after IVTA. DESIGN: Prospective, nonrandomized, interventional case series. METHODS: setting: Institutional. patients: Nineteen eyes of 19 consecutive patients with RRD. intervention: All 19 eyes underwent IVTA 1 day before 25-gauge vitrectomy. Seventeen eyes free of retinal vascular disease served as controls. main outcome measure: Both baseline and 1 day post-IVTA measurements were made of the relative concentrations of 15 soluble factors (3 cytokines, 7 chemokines, and 5 growth factors). The associations with clinical findings, including macular status, were then analyzed. RESULTS: Elevated monocyte chemotactic protein 1 (MCP-1), macrophage inflammatory protein 1β (MIP-1β), and interferon γ-induced protein 10 (IP-10) in eyes with RRD were significantly reduced after IVTA. MCP-1 levels were significantly correlated with MIP-1β and IP-10 before and after IVTA. The decreases in MCP-1, MIP-1β, and IP-10 were also closely correlated to each other. Both before and after IVTA, MCP-1 was higher in eyes with macula-off RRD than in eyes with macula-on RRD. CONCLUSIONS: IVTA suppressed elevated levels of intraocular MCP-1, MIP-1β, and IP-10 in eyes with RRD. The decrease in the aqueous levels of each of these factors was significantly correlated with the others. In addition to MCP-1, MIP-1β and IP-10 might potentially be additional target molecules for RRD therapy.

  76. Effect of Topical Tafluprost on Optic Nerve Head Blood Flow in Patients With Myopic Disc Type Peer-reviewed

    Satoru Tsuda, Yu Yokoyama, Naoki Chiba, Naoko Aizawa, Yukihiro Shiga, Masayuki Yasuda, Shunji Yokokura, Takaaki Otomo, Nobuo Fuse, Toru Nakazawa

    JOURNAL OF GLAUCOMA　22　(5)　398-403　2013/06

    DOI： 10.1097/IJG.0b013e318237c8b3 　

    ISSN： 1057-0829

  77. Visual outcome after intravitreal bevacizumab depends on the optical coherence tomographic patterns of patients with diffuse diabetic macular edema. International-journal Peer-reviewed

    Masahiko Shimura, Kanako Yasuda, Masayuki Yasuda, Toru Nakazawa

    Retina (Philadelphia, Pa.)　33　(4)　740-7　2013/04

    DOI： 10.1097/IAE.0b013e31826b6763 　

    ISSN： 0275-004X 1539-2864

  78. Metabolic stress response implicated in diabetic retinopathy: the role of calpain, and the therapeutic impact of calpain inhibitor. International-journal Peer-reviewed

    Ahmed Y Shanab, Toru Nakazawa, Morin Ryu, Yuji Tanaka, Noriko Himori, Keiko Taguchi, Masayuki Yasuda, Ryo Watanabe, Jiro Takano, Takaomi Saido, Naoko Minegishi, Toshio Miyata, Toshiaki Abe, Masayuki Yamamoto

    Neurobiology of disease　48　(3)　556-67　2012/12

    DOI： 10.1016/j.nbd.2012.07.025 　

    ISSN： 0969-9961

  79. Critical role of calpain in axonal damage-induced retinal ganglion cell death. International-journal Peer-reviewed

    Morin Ryu, Masayuki Yasuda, Dong Shi, Ahmed Y Shanab, Ryo Watanabe, Noriko Himori, Kazuko Omodaka, Yu Yokoyama, Jiro Takano, Takaomi Saido, Toru Nakazawa

    Journal of neuroscience research　90　(4)　802-15　2012/04

    DOI： 10.1002/jnr.22800 　

    ISSN： 0360-4012

  80. Choroidal blood flow following photodynamic therapy measured by laser speckle flowgraphy

    Fumihiko Nitta, Hiroshi Kunikata, Toru Nakazawa, Jiro Kinugawa, Masayuki Yasuda, Toshiaki Abe

    Japanese Journal of Clinical Ophthalmology　65　(6)　863-868　2011/06/15

    ISSN： 0370-5579

  81. Suppression of phagocytic cells in retinal disorders using amphiphilic poly(γ-glutamic acid) nanoparticles containing dexamethasone. International-journal Peer-reviewed

    Morin Ryu, Toru Nakazawa, Takami Akagi, Tatsuhide Tanaka, Ryou Watanabe, Masayuki Yasuda, Noriko Himori, Kazuichi Maruyama, Toshihide Yamashita, Toshiaki Abe, Mitsuru Akashi, Kohji Nishida

    Journal of controlled release : official journal of the Controlled Release Society　151　(1)　65-73　2011/04/10

    DOI： 10.1016/j.jconrel.2010.11.029 　

    ISSN： 0168-3659

  82. Tumor necrosis factor-alpha mediates photoreceptor death in a rodent model of retinal detachment. International-journal Peer-reviewed

    Toru Nakazawa, Maki Kayama, Morin Ryu, Hiroshi Kunikata, Ryou Watanabe, Masayuki Yasuda, Jiro Kinugawa, Demetrios Vavvas, Joan W Miller

    Investigative ophthalmology & visual science　52　(3)　1384-91　2011/03

    DOI： 10.1167/iovs.10-6509 　

    ISSN： 0146-0404

  83. Reproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-NAVI in patients with glaucoma. International-journal Peer-reviewed

    Naoko Aizawa, Yu Yokoyama, Naoki Chiba, Kazuko Omodaka, Masayuki Yasuda, Takaaki Otomo, Masahiko Nakamura, Nobuo Fuse, Toru Nakazawa

    Clinical ophthalmology (Auckland, N.Z.)　5　1171-6　2011

    DOI： 10.2147/OPTH.S22093 　

    ISSN： 1177-5467

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    BACKGROUND: Laser speckle flowgraphy (LSFG) enables noninvasive quantification of the retinal circulation in glaucoma patients. In this study, we tested the intrasession reproducibility of LSFG-NAVI, a modified LSFG technique. METHODS: Sixty-five eyes from 33 subjects (male (M):female (F) = 17:16) with a mean age of 49.4 ± 11.2 years were examined in this study. Two parameters indicating reproducibility - the coefficient of variation (COV) and the intraclass correlation coefficient (ICC) - were analyzed three times on the same day that mean blur rate (MBR) was measured using LSFG-NAVI. The sites analyzed were the retinal artery and vein, the optic disk, and the choroid. Following classification according to the Glaucoma Hemifield Test (GHT; SITA-Standard 30-2 program), the COV and ICC were examined in patients with (GHT+; 38 eyes, M:F = 20:18, average age 48.9 ± 12.8 years) and without (GHT-; 27 eyes, M:F = 13:14, average age 50.1 ± 8.7 years) abnormal glaucomatous visual fields. RESULTS: FOR ALL SUBJECTS, THE INTRASESSION REPRODUCIBILITY OF MBR IN THE OPTIC DISK (COV: 3.4 ± 2.0; ICC: 0.95) and choroid (COV: 4.7 ± 3.4; ICC: 0.98) was excellent. The reproducibility for the retinal vein (COV: 8.4 ± 5.6, ICC: 0.90) and retinal artery (COV: 10.9 ± 9.9, ICC: 0.9) was moderate. MBRs in the optic disk had good reproducibility in both the GHT+ group (COV: 3.8 ± 2.0; ICC: 0.97) and the GHT- group (COV: 2.9 ± 2.1; ICC: 0.95). Local assessment of the optic disk in normal or glaucoma patients showed that the COVs of the quadrant optic disk areas were best in the temporal area of MBR (3.4%, 4.2%, respectively). CONCLUSION: LSFG-NAVI showed favorable reproducibility in evaluation of retinal circulation of glaucoma patients, particularly in the optic disk and choroid.

  84. Association between optic nerve blood flow and objective examinations in glaucoma patients with generalized enlargement disc type. International-journal Peer-reviewed

    Naoki Chiba, Kazuko Omodaka, Yu Yokoyama, Naoko Aizawa, Satoru Tsuda, Masayuki Yasuda, Takaaki Otomo, Shunji Yokokura, Nobuo Fuse, Toru Nakazawa

    Clinical ophthalmology (Auckland, N.Z.)　5　1549-56　2011

    DOI： 10.2147/OPTH.S22097 　

    ISSN： 1177-5467

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    BACKGROUND: The purpose of this study was to investigate the correlations between microcirculation in the optic disc, average peripapillary retinal nerve fiber layer thickness cupping parameters, and visual field defects in glaucoma patients with the generalized enlargement disc type. METHODS: A total of 38 eyes from 38 glaucoma patients with the generalized enlargement disc type were included. The microcirculation of the optic nerve head was examined with laser speckle flow graphy, and the mean blur rate in all areas, in vessel area, and in tissue area were calculated using the laser speckle flow graphy analyzer software. Average peripapillary retinal nerve fiber layer thickness was measured using Stratus optical coherence tomography, and cupping parameters were accessed using the Heidelberg retina tomograph. The mean deviation in the Humphrey field analyzer (30-2 SITA standard) was analyzed. The correlation between these parameters was evaluated using the Spearman rank correlation coefficient. RESULTS: The correlation coefficient of mean blur rate in all optic disc area to the average peripapillary retinal nerve fiber layer thickness, vertical C/D, and mean deviation were r = 0.7546 (P < 0.0001), r = -0.6208 (P < 0.0001), and r = 0.6010 (P = 0.0001), respectively. The mean blur rate in tissue area of the optic disc showed r = 0.7305 (P < 0.0001), r = -0.6438 (P < 0.0001), and r = 0.6338 (P < 0.0001). CONCLUSION: We found that the mean blur rate in the optic disc was significantly correlated with the average peripapillary retinal nerve fiber layer thickness, vertical C/D, and mean deviation in patients with the generalized enlargement disc type of glaucoma. In particular, the mean blur rate in tissue area was more highly correlated than the vessel area with other results of examination in glaucoma patients with the generalized enlargement disc type.

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Misc. 78

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    ISSN： 0029-0203

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    日本糖尿病眼学会総会講演抄録集　31st　2025

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    日本網膜硝子体学会総会プログラム・講演抄録集　62nd　2023

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    日本網膜硝子体学会総会プログラム・講演抄録集　61st　2022

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    日本眼科学会雑誌　126　2022

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    日本眼科学会雑誌　124　2020

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    糖尿病　62　(Suppl.1)　S-128　2019/04

    Publisher: (一社)日本糖尿病学会

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    日本眼科学会雑誌　123　(臨増)　221-221　2019/03

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    日本眼科学会雑誌　123　(臨増)　156-156　2019/03

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    ISSN： 0029-0203

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    日本眼科学会雑誌　123　(臨増)　173-173　2019/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  19. 特発性黄斑前膜の術後網膜内層厚と術前黄斑部血管密度の部位別関連

    安田 正幸, 國方 彦志, 長田 麗, 橋本 和軌, 中澤 徹

    日本眼科学会雑誌　123　(臨増)　206-206　2019/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  20. 糖尿病神経障害と視神経乳頭血流波形パラメータの関連

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    日本網膜硝子体学会総会プログラム・講演抄録集　58th　2019

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    日本網膜硝子体学会総会プログラム・講演抄録集　58th　2019

  22. 2型糖尿病患者におけるLaser speckle flowgraphyによる視神経乳頭領域の眼血流指標と超音波検査による頸動脈血流指標との関係

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    糖尿病(Web)　62　(Suppl)　2019

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    安田 正幸, 橋本 和軌, 針谷 威寛, 中山 紘子, 浅野 俊文, 鈴木 哲章, 宗像 正徳, 中澤 徹, 佐藤 肇

    日本眼科学会雑誌　122　(臨増)　186-186　2018/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  24. 網膜中心動脈閉塞症に対する高圧酸素療法の治療効果と治療後視力に関連する因子の検討

    橋本 和軌, 安田 正幸, 針谷 威寛, 中山 紘子, 浅野 俊文, 鈴木 哲章, 宗像 正徳, 中澤 徹, 佐藤 肇

    日本眼科学会雑誌　122　(臨増)　268-268　2018/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  25. 緑内障患者におけるFlammer問診票の有用性

    高橋成奈, 志賀由己浩, 安田正幸, 佐藤茉莉華, 清田直樹, 津田聡, 面高宗子, 檜森紀子, 高山真, 石井正, 中澤徹

    日本緑内障学会抄録集　29th　2018

  26. 緑内障患者のベースライン4分割視神経乳頭組織血流が対応する部位の視野進行に与える影響

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    日本緑内障学会抄録集　29th　76　2018

  27. 糖尿病患者における黄斑部表層毛細血管密度と視神経乳頭血流波形パラメータの関連

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    日本網膜硝子体学会総会プログラム・講演抄録集　57th　70　2018

  28. 早期糖尿病網膜症患者における浅層中心窩無血管領域と心臓足首血管指数の関連

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    日本網膜硝子体学会総会プログラム・講演抄録集　57th　71　2018

  29. 全身性エリテマトーデス患者における眼血流解析

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    眼科臨床紀要　10　(10)　849-849　2017/10

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  30. 糖尿病網膜症における強膜自発蛍光測定の有用性の検討

    安田 正幸, 國方 彦志, 相澤 奈帆子, 田中 佑治, 永富 良一, 中澤 徹

    眼科臨床紀要　9　(10)　853-854　2016/10

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  31. 黄斑円孔に対するinverted ILM flap法の術後成績とOCT所見

    橋本和軌, 國方彦志, 安田正幸, 相澤奈帆子, 伊藤梓, 中澤徹

    日本眼科学会雑誌　120　(臨増)　281-281　2016/03/02

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  32. 早期糖尿病網膜症患者における脈絡膜厚と運動神経伝導速度の関係

    伊藤 梓, 國方 彦志, 安田 正幸, 澤田 正二郎, 近藤 敬一, 佐竹 千尋, 橋本 和軌, 相澤 奈帆子, 片桐 秀樹, 中澤 徹

    日本眼科学会雑誌　120　(臨増)　217-217　2016/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  33. ラット視神経挫滅モデルの網膜トランスクリプトーム解析

    安田 正幸, 西口 康二, 面高 宗子, 田中 佑治, 中澤 徹

    日本眼科学会雑誌　120　(臨増)　246-246　2016/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  34. 全身性エリテマトーデス患者における眼血流解析

    伊藤梓, 國方彦志, 安田正幸, 相澤奈帆子, 石井智徳, 中澤徹

    日本網膜硝子体学会総会プログラム・講演抄録集　55th　75　2016

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    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　88回・38回　[4T18p-11(3P1293)]　2015/12

    Publisher: (公社)日本生化学会

  36. Role of GDNF receptor-related genes to axonal damage-induced retinal ganglion cell death and regeneration

    Kazuko Omodaka, Takuji Kurimoto, Orie Nakamura, Kota Sato, Masayuki Yasuda, Noriko Himori, Yu Yokoyama, Toru Nakazawa

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　56　(7)　2015/06

    ISSN： 0146-0404

    eISSN： 1552-5783

  37. マウス視神経挫滅モデルにおけるScotopic Threshold Response早期変化

    雪田 昌克, 町田 繁樹, 西口 康二, 津田 聡, 田中 佑治, 横山 悠, 安田 正幸, 丸山 和一, 中澤 徹

    眼科臨床紀要　8　(4)　251-251　2015/04

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  38. 眼疾患メカニズムの新しい理解 失明ゼロを目指して

    中澤 徹, 國方 彦志, 横倉 俊二, 丸山 和一, 西口 康二, 高橋 秀肇, 国松 志保, 劉 孟林, 檜森 紀子, 田中 佑治, 新田 文彦, 森藤 暁, 藤田 幸輔, 中村 織江, 面高 宗子, 安田 正幸, 横山 悠, 相澤 奈帆子, 山本 耕太郎, 雪田 昌克, 津田 聡, 志賀 由己浩, 前川 重人, 國分 太貴, 今野 瑛之, 高橋 麻衣, 萱場 寛子, 橋本 清香, 佐藤 茉莉華, 矢花 武史, 高田 菜生子, 高橋 世理, 鎌田 泰彰

    日本眼科学会雑誌　119　(3)　168-194　2015/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  39. RNAシークエンスを用いたラット視神経軸索障害モデルの網膜トランスクリプトーム解析

    安田 正幸, 西口 康二, 面高 宗子, 田中 佑治, 中澤 徹

    日本眼科学会雑誌　119　(臨増)　242-242　2015/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  40. パスウェイ特異的レポーターによる網膜神経節細胞ストレス応答のin vivoイメージング

    西口 康二, 藤田 幸輔, 藤井 裕介, 山本 耕太郎, 津田 聡, 安田 正幸, 中澤 徹

    日本眼科学会雑誌　119　(臨増)　244-244　2015/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  41. 早期糖尿病網膜症患者における皮膚自発蛍光と眼血流の関係

    橋本 和軌, 國方 彦志, 安田 正幸, 伊藤 梓, 相澤 奈帆子, 西口 康二, 近藤 敬一, 澤田 正二郎, 佐竹 千尋, 中澤 徹

    日本眼科学会雑誌　119　(臨増)　254-254　2015/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  42. マウス視神経挫滅モデルにおけるscotopic threshold response早期変化

    雪田 昌克, 町田 繁樹, 西口 康二, 津田 聡, 横山 悠, 安田 正幸, 丸山 和一, 中澤 徹

    日本眼科学会雑誌　119　(2)　80-80　2015/02

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  43. 糖尿病網膜症における強膜自発蛍光測定の有用性の検討

    安田正幸, 國方彦志, 相澤奈帆子, 田中佑治, 永富良一, 中澤徹

    日本網膜硝子体学会総会プログラム・講演抄録集　54th　85　2015

  44. 12方向網膜視神経線維層厚と静的自動視野計検査点との相関

    鈴木 哲章, 横山 悠, 国松 志保, 今野 瑛之, 安田 正幸, 西口 康二, 中澤 徹

    日本緑内障学会抄録集　25回　96-96　2014/09

    Publisher: 日本緑内障学会

  45. In vivo imagingによる視神経挫滅後の網膜神経節細胞死の評価

    津田 聡, 田中 佑治, 國方 彦志, 横山 悠, 安田 正幸, 中澤 徹

    日本緑内障学会抄録集　25回　115-115　2014/09

    Publisher: 日本緑内障学会

  46. マウス軸索障害に対するheme oxygenase-1の内在性神経保護作用

    檜森 紀子, 丸山 和一, 山本 耕太郎, 安田 正幸, 劉 孟林, 面高 宗子, 志賀 由己浩, 中澤 徹

    日本抗加齢医学会総会プログラム・抄録集　14回　324-324　2014/06

    Publisher: (一社)日本抗加齢医学会

  47. 眼疾患と遺伝子 緑内障のゲノム解析 次世代医療・個別化医療に向けて

    布施 昇男, 清水 愛, 木村 雅恵, 高野 良真, 石 棟, 宮澤 晃子, 国松 志保, 劉 孟林, 渡邉 亮, 安田 正幸, 横山 悠, 檜森 紀子, 津田 聡, 山本 耕太郎, 中澤 徹, 安田 純, 勝岡 史城, 小島 要, 成相 直樹, 松本 光代, 元池 育子, 長崎 正朗, 木下 賢吾, 五十嵐 和彦, 山本 雅之, 新堀 哲也, 青木 洋子, 松原 洋一, 舟山 亮, 長嶋 剛史, 中山 啓子, 眞島 行彦, 船山 智代, 田中 光一, 原田 高幸, 阿部 春樹, 福地 健郎, 安田 典子, 出田 秀尚, 鄭 暁東, 白石 敦, 大橋 裕一, 石田 誠夫, 原 岳, 金森 章泰, 山田 裕子, 中村 誠, 酒井 寛, Richards Julia E

    日本眼科学会雑誌　118　(3)　216-240　2014/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  48. 濾過胞の生存に関与する前房水サイトカインの検討

    國分 太貴, 津田 聡, 安田 正幸, 清水 愛, 横山 悠, 渡邊 亮, 劉 孟林, 国松 志保, 丸山 和一, 國方 彦志, 中澤 徹

    日本眼科学会雑誌　118　(1)　48-48　2014/01

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  49. 濾過胞の生存に関与する前房水サイトカインの検討

    國分 太貴, 津田 聡, 安田 正幸, 清水 愛, 横山 悠, 渡邉 亮, 劉 孟林, 国松 志保, 丸山 和一, 中澤 徹

    日本緑内障学会抄録集　24回　47-47　2013/09

    Publisher: 日本緑内障学会

  50. RNA-Seqによるマウス視神経挫滅後早期における網膜の網羅的遺伝子発現定量解析

    田中 佑治, 安田 正幸, 中澤 徹

    日本緑内障学会抄録集　24回　51-51　2013/09

    Publisher: 日本緑内障学会

  51. 緑内障に関連する前房水miRNAマーカーのマイクロアレイ解析

    津田 聡, 田中 佑治, 安田 正幸, 佐藤 順子, 國分 太貴, 中澤 徹

    日本緑内障学会抄録集　24回　51-51　2013/09

    Publisher: 日本緑内障学会

  52. 低酸素応答生理活性蛍光プローブを用いた網膜低酸素領域のin vivoイメージング

    津田 聡, 田中 佑治, 朴 文, 國方 彦志, 横山 悠, 安田 正幸, 花岡 健二郎, 長野 哲雄, 中澤 徹

    日本眼科学会雑誌　117　(臨増)　280-280　2013/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  53. エリスロポエチンノックアウトマウスを用いた網膜・視神経の組織学的検討

    安田 正幸, 劉 孟林, 田中 佑治, 檜森 紀子, 面高 宗子, 横山 悠, 雪田 昌克, 津田 聡, 丸山 和一, 山本 雅之, 中澤 徹

    日本眼科学会雑誌　117　(臨増)　311-311　2013/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  54. 酸化ストレスによる網膜神経節細胞死におけるカルパインの働き

    横山 悠, 劉 孟林, 山本 耕太郎, 安田 正幸, 田中 佑治, 丸山 和一, 中澤 徹

    日本眼科学会雑誌　117　(臨増)　332-332　2013/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  55. 巨大裂孔網膜剥離に対するMIVSと20G硝子体手術の比較

    國方 彦志, 阿部 俊明, 新田 文彦, 安田 正幸, 玉井 洋, 相澤 奈帆子, 中澤 徹

    眼科臨床紀要　5　(10)　960-960　2012/10

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  56. 加齢黄斑変性症におけるラニビズマブ硝子体内投与前後の眼循環血流変化

    新田 文彦, 國方 彦志, 安田 正幸, 玉井 洋, 阿部 俊明, 中澤 徹

    眼科臨床紀要　5　(10)　976-977　2012/10

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  57. 黄斑円孔術後に発症した脈絡膜新生血管の一例

    伊藤 梓, 國方 彦志, 阿部 俊明, 安田 正幸, 中澤 徹

    眼科臨床紀要　5　(9)　855-859　2012/09

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  58. 正常眼圧緑内障における視神経乳頭血流と皮膚AGEとの相関

    高橋 秀肇, 金澤 紘子, 劉 孟林, 安田 正幸, 宮田 敏男, 中澤 徹

    日本緑内障学会抄録集　23回　99-99　2012/09

    Publisher: 日本緑内障学会

  59. 軸索流障害による網膜神経節細胞死のcalpain pathwayの関与

    劉 孟林, 横山 悠, 安田 正幸, アハメッド・シャナブ, 檜森 紀子, 面高 宗子, 渡辺 亮, 高野 二郎, 西道 隆臣, 中澤 徹

    日本緑内障学会抄録集　23回　102-102　2012/09

    Publisher: 日本緑内障学会

  60. 正常眼圧緑内障における進行予測因子としての皮膚AGEの有用性

    金澤 紘子, 劉 孟林, 安田 正幸, 面高 宗子, 橋本 清香, 國分 太貴, 今野 瑛之, 宮田 敏男, 佐藤 肇, 中澤 徹

    日本緑内障学会抄録集　23回　112-112　2012/09

    Publisher: 日本緑内障学会

  61. アポリポ蛋白質E欠損マウスにおけるカイニン酸障害および軸索障害に対する網膜神経節細胞の保護効果

    田中 佑治, Ahmed Shanab, 安田 正幸, 面高 宗子, 横山 悠, 劉 孟林, 中澤 徹

    日本緑内障学会抄録集　23回　152-152　2012/09

    Publisher: 日本緑内障学会

  62. DNAマイクロアレイによるラタノプロストの神経保護作用の解析

    山本 耕太郎, 劉 孟林, 面高 宗子, 安田 正幸, 中澤 徹

    日本緑内障学会抄録集　23回　153-153　2012/09

    Publisher: 日本緑内障学会

  63. 特発性黄斑円孔に対する硝子体手術成績とトリアムシノロンアセトニドの効果

    金澤 紘子, 國方 彦志, 安田 正幸, 新田 文彦, 鬼怒川 次郎, 阿部 俊明, 中澤 徹

    臨床眼科　66　(8)　1219-1224　2012/08

    Publisher: (株)医学書院

    DOI： 10.11477/mf.1410104327 　

    ISSN： 0370-5579

    eISSN： 1882-1308

  64. Outcome of microincision vitrectomy for idiopathic macular hole with or without triamcinolone acetonide

    金澤 紘子, 國方 彦志, 安田 正幸

    臨床眼科　66　(8)　1219-1224　2012/08

    Publisher: 医学書院

    DOI： 10.11477/mf.1410104327 　

    ISSN： 0370-5579

  65. 糖尿病黄斑浮腫に対するベバシズマブ・トリアムシノロン併用療法

    志村 雅彦, 安田 佳奈子, 安田 尚子, 安田 正幸, 中澤 徹

    日本眼科学会雑誌　116　(臨増)　264-264　2012/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  66. 酸化ストレス研究における網膜神経節細胞純化回収法の確立

    檜森 紀子, 田口 恵子, 劉 孟林, 安田 正幸, 横山 悠, 相澤 奈帆子, 面高 宗子, 山本 雅之, 中澤 徹

    日本眼科学会雑誌　116　(臨増)　303-303　2012/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  67. 漿液性網膜剥離を伴う網膜血管腫にトリアムシノロンテノン嚢下注射が奏功した1例

    安田 正幸, 阿部 俊明, 國方 彦志, 鬼怒川 次郎, 新田 文彦

    眼科臨床紀要　4　(10)　1007-1007　2011/10

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  68. 全身虚血性疾患合併の緑内障における皮膚AGE測定の有用性

    金澤 紘子, 安田 正幸, 志村 雅彦, 布施 昇男, 宮田 敏男, 中澤 徹

    日本緑内障学会抄録集　22回　101-101　2011/09

    Publisher: 日本緑内障学会

  69. レーザースペックルフローグラフィを用いた光線力学療法後の血流解析

    新田 文彦, 國方 彦志, 中澤 徹, 鬼怒川 次郎, 安田 正幸, 阿部 俊明

    臨床眼科　65　(6)　863-868　2011/06

    Publisher: (株)医学書院

    DOI： 10.11477/mf.1410103693 　

    ISSN： 0370-5579

  70. マウス網膜神経節細胞障害におけるNrf2の役割

    檜森 紀子, 中澤 徹, 田口 恵子, 劉 孟林, 安田 正幸, 面高 宗子, シャナブ・アフメド, 山本 雅之

    日本眼科学会雑誌　115　(臨増)　252-252　2011/04

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  71. 軸索流障害による正常眼圧緑内障モデルにおけるカルパイン阻害剤の神経保護効果

    安田 正幸, 劉 孟林, 檜森 紀子, 面高 宗子, シャナブ・アフメド, 高野 二郎, 西道 隆臣, 中澤 徹

    日本眼科学会雑誌　115　(臨増)　253-253　2011/04

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  72. 当院における増殖性糖尿病網膜症の悪化因子の検討

    鬼怒川 次郎, 國方 彦志, 阿部 俊明, 新田 文彦, 安田 正幸, 布施 昇男

    日本眼科学会雑誌　115　(臨増)　301-301　2011/04

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  73. 加齢黄斑変性症におけるラニビズマブ硝子体内投与前後の眼循環血流変化

    新田文彦, 國方彦志, 安田正幸, 玉井洋, 阿部俊明, 中澤徹

    日本糖尿病眼学会総会講演抄録集　17th　121　2011

  74. 巨大裂孔網膜剥離に対するMIVSと20G硝子体手術の比較

    國方彦志, 阿部俊明, 新田文彦, 安田正幸, 玉井洋, 相澤奈帆子, 中澤徹

    日本糖尿病眼学会総会講演抄録集　17th　99　2011

  75. 強度近視黄斑円孔に対する硝子体手術後の脈絡膜新生血管

    伊藤梓, 國方彦志, 安田正幸, 新田文彦, 阿部俊明, 中澤徹

    日本糖尿病眼学会総会講演抄録集　17th　114　2011

  76. 漿液性網膜剥離を伴う網膜血管腫にトリアムシノロンテノン嚢下注射が奏功した一例

    安田正幸, 阿部俊明, 國方彦志, 鬼怒川次郎, 新田文彦

    日本糖尿病眼学会総会講演抄録集　16th　106　2010

  77. Churg-Strauss症候群に網膜動脈分枝閉塞症を合併した1例

    安田 正幸, 清宮 基彦, 板橋 俊隆

    臨床眼科　63　(7)　1159-1162　2009/07

    Publisher: (株)医学書院

    DOI： 10.11477/mf.1410102801 　

    ISSN： 0370-5579

  78. Branch retinal artery occlusion in a case of Churg-Strauss syndrome

    安田 正幸, 清宮 基彦, 板橋 俊隆

    臨床眼科　63　(7)　1159-1162　2009/07

    Publisher: 医学書院

    DOI： 10.11477/mf.1410102801 　

    ISSN： 0370-5579

Show all ︎Show first 5

Industrial Property Rights 3

  1. 視神経障害発症リスクの判定方法

    田中 佑治, 安田 正幸, 面高 宗子, 中澤 徹

    Property Type: Patent

  2. 蛍光測定装置及び蛍光測定方法

    目賀 章正, 田中 佑治, 安田 正幸, 永富 良一, 中澤 徹

    Property Type: Patent

  3. 蛍光測定装置及び蛍光測定方法

    目賀 章正, 田中 佑治, 安田 正幸, 永富 良一, 中澤 徹

    特許第6161693号

    Property Type: Patent

Research Projects 5

  1. 心眼脳連関に着目したマルチモーダル解析での循環器病・認知症個別化リスク層別法開発

    中野 誠, 安田 正幸, 野田 崇, 後岡 広太郎, 中澤 徹, 國方 彦志, 長谷部 雄飛

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2024/04/01 - 2027/03/31

  2. STING経路に着目した滲出型加齢黄斑変性の網膜下線維化の病態解明

    安田 正幸, 俵山 寛司, 佐藤 孝太

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2023/04/01 - 2026/03/31

  3. 酸化ストレスによる細胞老化とSTING経路に着目した糖尿病網膜症の病態解明

    安田 正幸

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 若手研究

    Institution: 東北大学

    2021/04/01 - 2023/03/31

    More details Close

    糖尿病網膜症は糖尿病の細小血管合併症の一つであり、就労年齢に多い失明疾患である。このため、労働力人口が減少している少子超高齢化社会において特に対策が必要な疾患である。糖尿病網膜症は高血糖が主要な病態ではあるが、同程度に血糖降下しても予後には個人差があり、様々な血糖降下薬が臨床応用されている にもかかわらず十分な失明予防ができていない。本研究では、糖尿病網膜症の高血糖以外の病態として酸化ストレスと細胞老化に着目し、生体試料解析と、培養細胞や動物実験を用いた基礎研究の両面からバイオマーカーの同定と病態解明をすることを目的として研究を行っている。2021年度は、東北大学眼科外来を受診した糖尿病患者で生体試料の収集を行った。血液を採取し、遺伝子やタンパク質解析のための試料を蓄積した。同日に血液の酸化ストレス測定も行った。酸化ストレス測定にはフリーラジカル解析装置(FREE carpe diem、ウィスマー社)を用い、全身の酸化ストレス度 (dROM)値と抗酸化能(BAP)値を測定した。さらに、光干渉断層計や光干渉断層血管撮影も同時に撮影した。遺伝子やタンパク質、酸化ストレスといった生体試料解析のマーカーと糖尿病網膜症の有無や重症度との関連を調べ、さらに、黄斑部毛細血管密度など早期糖尿病網膜症と関連するパラメータとの関連を現在検討している。次年度は、生体試料を引き続き収集し解析を行い、糖尿病網膜症の病態に関連が示唆される分子を同定しながら基礎研究で検証を行っていく。

  4. Gut microbiome and genetic variants in exudative age-related macular degeneration

    Yasuda Masayuki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Early-Career Scientists

    Institution: Tohoku University

    2019/04/01 - 2021/03/31

    More details Close

    Age-related macular degeneration (AMD) is an important ocular disease that is one of the leading causes of blindness in adults. In this study, we investigated the relationship of blood oxidative stress marker (i.e., oxidative stress level (dROM) and antioxidant capacity (BAP)) with exudative AMD (wAMD) using a free radical analyzer. The results showed that dROM was significantly higher in the wAMD group (P<0.01). Next, we extracted DNA from the feces of the wAMD patients, then, performed 16s rRNA sequence. The results showed significant changes in the composition of the phylum Bacteroidetes and Verrucomicrobia in wAMD. This study suggests that oxidative stress and changes in the gut microbiota are associated with the pathogenesis of wAMD.

  5. CAGE 法を用いた 2 型糖尿病における網膜神経障害の病態解明

    安田 正幸

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 若手研究(B)

    Institution: 東北大学

    2016/04/01 - 2018/03/31