Details of the Researcher

PHOTO

Ryusuke Inoue
Section
Tohoku University Hospital
Job title
Senior Assistant Professor
Degree
  • 博士(医学)(東北大学)

Research Areas 1

  • Life sciences / Medical systems /

Papers 162

  1. Association between the Number of Deliveries and Cognitive Impairment Considering the Presence of Subclinical Cerebrovascular Diseases: the Ohasama Study

    Teiichiro Yamazaki, Kyoko Nomura, Michihiro Satoh, Azusa Hara, Megumi Tsubota-Utsugi, Takahisa Murakami, Kei Asayama, Yukako Tatsumi, Yuki Kobayashi, Takuo Hirose, Ryusuke Inoue, Tomoko Totsune, Masahiro Kikuya, Hirohito Metoki, Atsushi Hozawa, Yutaka Imai, Takayoshi Ohkubo

    The Tohoku Journal of Experimental Medicine 2024

    Publisher: Tohoku University Medical Press

    DOI: 10.1620/tjem.2024.j139  

    ISSN: 0040-8727

    eISSN: 1349-3329

  2. Female Reproductive Events and Subclinical Atherosclerosis of the Brain and Carotid Arteriopathy: the Ohasama Study.

    Wakana Sato, Kyoko Nomura, Michihiro Satoh, Azusa Hara, Megumi Tsubota-Utsugi, Takahisa Murakami, Kei Asayama, Yukako Tatsumi, Yuki Kobayashi, Takuo Hirose, Ryusuke Inoue, Tomoko Totsune, Masahiro Kikuya, Atsushi Hozawa, Hirohito Metoki, Yutaka Imai, Hiroyuki Watanabe, Takayoshi Ohkubo

    Journal of atherosclerosis and thrombosis 30 (8) 956-978 2022/10/05

    DOI: 10.5551/jat.63592  

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    AIMS: Few studies have investigated the subclinical atherosclerotic changes in the brain and carotid artery, and in East Asian populations. We sought to investigate whether gravidity, delivery, the age at menarche and menopause and estrogen exposure period are associated with subclinical atherosclerosis of the brain and carotid arteriopathy. METHODS: This cross-sectional study formed part of a cohort study of Ohasama residents initiated in 1986. Brain atherosclerosis and carotid arteriopathy were diagnosed as white matter hyperintensity (WMH) and lacunae evident on brain magnetic resonance imaging (MRI) and carotid intimal media thickness (IMT) or plaque revealed by ultrasound, respectively. The effect of the reproductive events on brain atherosclerosis and carotid arteriopathy was investigated using logistic regression and general linear regression models after adjusting for covariates. RESULTS: Among 966 women aged ≥ 55 years in 1998, we identified 622 and 711 women (mean age: 69.2 and 69.7 years, respectively) who underwent either MRI or carotid ultrasound between 1992-2008 or 1993-2018, respectively. The highest quartile of gravidity (≥ 5 vs. 3) and delivery (≥ 4 vs. 2), and the highest and second highest (3 vs. 2) quartiles of delivery were associated with an increased risk of WMH and carotid artery plaque, respectively. Neither of age at menarche, menopause, and estrogen exposure period estimated by subtracting age at menarche from age at menopause was associated with atherosclerotic changes of brain and carotid arteries. CONCLUSIONS: Higher gravidity and delivery are associated with subclinical atherosclerosis of the brain and carotid plaque.

  3. 尿ナトリウム/カリウム比と脳性ナトリウム利尿ペプチド 大迫研究

    室谷 智子, 佐藤 倫広, 村上 任尚, 中山 晋吾, 廣瀬 卓男, 橋本 英明, 遠山 真弥, 高畠 恭介, 辰巳 友佳子, 井上 隆輔, 坪田 恵[宇津木], 小暮 真奈, 中谷 直樹, 浅山 敬, 野村 恭子, 菊谷 昌浩, 目時 弘仁, 今井 潤, 寳澤 篤, 大久保 孝義

    東北公衆衛生学会誌 (71) 29-30 2022/07

    Publisher: 東北公衆衛生学会

    ISSN: 0915-549X

  4. Association of home and office systolic and diastolic hypertension with glucose metabolism in a general population: the Ohasama study. International-journal

    Yukako Tatsumi, Michihiro Satoh, Kei Asayama, Takahisa Murakami, Takuo Hirose, Azusa Hara, Megumi Tsubota-Utsugi, Ryusuke Inoue, Masahiro Kikuya, Kyoko Nomura, Hirohito Metoki, Atsushi Hozawa, Hideki Katagiri, Yutaka Imai, Takayoshi Ohkubo

    Journal of hypertension 40 (7) 1336-1343 2022/07/01

    DOI: 10.1097/HJH.0000000000003145  

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    OBJECTIVE: This study was performed to investigate the association of hypertension subtypes with glucose metabolism among the Japanese general population. METHODS: The study involved 646 residents (mean age: 62.4 years) without treatment for hypertension or a history of diabetes from Ohasama, a rural Japanese community, who underwent an oral glucose tolerance test. Hypertension subtypes [normotension, isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), and systolic and diastolic hypertension (SDH)] were defined on the basis of home and office SBP and DBP (HBP and OBP, respectively). The estimated means of blood glucose related indices among the groups were compared by analysis of covariance adjusted for possible confounding factors. RESULTS: Blood glucose related indices were not different among the morning HBP-defined hypertension subtypes. Participants with evening HBP-defined ISH had a significantly higher estimated mean BG at 120 min, higher homeostasis model assessment-insulin resistance (HOMA-IR) and lower Matsuda-DeFronzo index than participants with NT (all P < 0.021). Participants with OBP-defined SDH had a significantly higher estimated mean fasting blood glucose; blood glucose at 30, 60 and 120 min; and HOMA-IR and a lower Matsuda-DeFronzo index than participants with NT (all P < 0.0025). CONCLUSION: The blood glucose related indices were different among hypertension subtypes. Participants with evening HBP-defined ISH and OBP-defined SDH had higher blood glucose levels and insulin resistance than participants with correspondingly defined normotension, while those with morning HBP did not. These findings suggest the importance of measuring evening HBP and office blood pressure for early detection of coexisting hypertension and diabetes.

  5. Regular dental visits, periodontitis, tooth loss, and atherosclerosis: The Ohasama study

    Sho Yamada, Takamasa Komiyama, Takashi Ohi, Takahisa Murakami, Yoshitada Miyoshi, Kosei Endo, Takako Hiratsuka, Azusa Hara, Michihiro Satoh, Yukako Tatsumi, Ryusuke Inoue, Kei Asayama, Masahiro Kikuya, Atsushi Hozawa, Hirohito Metoki, Yutaka Imai, Takayoshi Ohkubo, Yoshinori Hattori

    Journal of Periodontal Research 57 (3) 615-622 2022/06

    Publisher: Wiley

    DOI: 10.1111/jre.12990  

    ISSN: 0022-3484

    eISSN: 1600-0765

  6. Electronic Phenotyping to Identify Patients with Arrythmia Disease from a Hospital Information System

    Masaharu Nakayama, Ryusuke Inoue

    Studies in Health Technology and Informatics 2022/05/25

    Publisher: IOS Press

    DOI: 10.3233/shti220452  

    ISSN: 0926-9630

    eISSN: 1879-8365

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    Electronic phenotyping is an important method to identify a disease group by collecting clinical data from hospital information systems. This study aimed to extract accurate cases of supraventricular arrythmia, ventricular arrythmia, and bradycardia from clinical data of a hospital information system. The electronic phenotyping algorithm was improved using the machine learning method. Subsequently, it showed a higher area under the curve for prediction and higher specificity. However, the algorithm needs further improvement to classify each arrythmia disease accurately. In conclusion, phenotyping using clinical data from hospital information systems has some affinities and issues depending on the disease.

  7. Association between urinary sodium-to-potassium ratio and home blood pressure and ambulatory blood pressure: the Ohasama study. International-journal

    Tomoko Muroya, Michihiro Satoh, Takahisa Murakami, Shingo Nakayama, Kei Asayama, Takuo Hirose, Yukako Tatsumi, Ryusuke Inoue, Megumi Tsubota-Utsugi, Azusa Hara, Mana Kogure, Naoki Nakaya, Kyoko Nomura, Masahiro Kikuya, Hirohito Metoki, Yutaka Imai, Atsushi Hozawa, Takayoshi Ohkubo

    Journal of hypertension 40 (5) 862-869 2022/05/01

    DOI: 10.1097/HJH.0000000000003087  

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    OBJECTIVE: No studies have demonstrated the association between urinary sodium-to-potassium (Na/K) ratio and all out-of-office blood pressure (BP) [home morning and evening BP (self-measured at home), and 24-h, daytime, and night-time ambulatory BP] in the same cohort. We aimed to assess, which type of out-of-office BP is more strongly associated with urinary Na/K ratio in the general population. METHODS: This cross-sectional study was conducted in the general population of Ohasama, Japan. Home and ambulatory BP levels were measured, and 24-h urine samples were obtained from 875 participants (men, 25.5%; mean age, 60.1 years). The urinary Na/K ratio in the 24-h urine samples was calculated. RESULTS: The median (interquartile range) urinary Na/K ratio was 4.19 (3.36-5.26). Significant positive trends of home morning, home evening, 24-h, and daytime SBP were observed across quartiles of urinary Na/K ratio (trend P  < 0.041; adjusted mean values between Q1 and Q4 of urinary Na/K ratio: 121.0-125.5 mmHg for home morning, 120.1-123.8mmhg for home evening, 121.6-123.4mmHg for 24-h, 127.5-129.5 mmHg for daytime). Urinary Na/K ratio was not significantly associated with office or night-time SBP and nocturnal BP fall (trend P > 0.13). In the model with both home morning or evening SBP and daytime SBP, only home SBP was significantly associated with urinary Na/K ratio (P < 0.048 for home SBP). CONCLUSION: These findings suggest that urinary Na/K ratio might be more strongly associated with home BP than with 24-h and daytime BP but was not associated with night-time BP.

  8. Validity of Administrative Data for Identifying Birth-Related Outcomes with the End Date of Pregnancy in a Japanese University Hospital. International-journal

    Kentaro Tajima, Tomofumi Ishikawa, Fumiko Matsuzaki, Aoi Noda, Kei Morishita, Ryusuke Inoue, Noriyuki Iwama, Hidekazu Nishigori, Junichi Sugawara, Masatoshi Saito, Taku Obara, Nariyasu Mano

    International journal of environmental research and public health 19 (8) 2022/04/16

    DOI: 10.3390/ijerph19084864  

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    This study aimed to develop and validate claims-based algorithms for identifying live birth, fetal death, and cesarean section by utilizing administrative data from a university hospital in Japan. We included women who visited the Department of Obstetrics at a university hospital in 2018. The diagnosis, medical procedures, and medication data were used to identify potential cases of live birth, fetal death, and cesarean section. By reviewing electronic medical records, we evaluated the positive predictive values (PPVs) and the accuracy of the end date of pregnancy for each claims datum. "Selected algorithm 1" based on PPVs and "selected algorithm 2" based on both the PPVs and the accuracy of the end date of pregnancy were developed. A total of 1757 women were included, and the mean age was 32.8 years. The PPVs of "selected algorithm 1" and "selected algorithm 2" were both 98.1% for live birth, 99.0% and 98.9% for fetal death, and 99.7% and 100.0% for cesarean section, respectively. These findings suggest that the developed algorithms are useful for future studies for evaluating live birth, fetal death, and cesarean section with an accurate end date of pregnancy.

  9. Prediction Models for the 5- and 10-Year Incidence of Home Morning Hypertension: The Ohasama Study. International-journal

    Michihiro Satoh, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Takahisa Murakami, Yukako Tatsumi, Azusa Hara, Megumi Tsubota-Utsugi, Takuo Hirose, Ryusuke Inoue, Kyoko Nomura, Atsushi Hozawa, Yutaka Imai, Takayoshi Ohkubo

    American journal of hypertension 35 (4) 328-336 2022/04/02

    DOI: 10.1093/ajh/hpab177  

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    BACKGROUND: We aimed to develop risk prediction models for new-onset home morning hypertension. METHODS: We followed up 978 participants without home hypertension in the general population of Ohasama, Japan (men: 30.1%, age: 53.3 years). The participants were divided into derivation (n = 489) and validation (n = 489) cohorts by their residential area. The C-statistics and calibration plots were assessed after the 5- or 10-year follow-up. RESULTS: In the derivation cohort, sex, age, body mass index, smoking, office systolic blood pressure (SBP), and home SBP at baseline were selected as significant risk factors for new-onset home hypertension (≥135/85 mm Hg or the initiation of antihypertensive treatment) using the Cox model. In the validation cohort, Harrell's C-statistic for the 5-/10-year home hypertension was 0.7637 (0.7195-0.8100)/0.7308 (0.6932-0.7677), when we used the full model, which included the significant risk factors in the derivation cohort. The calibration test revealed good concordance between the observed and predicted 5-/10-year home hypertension probabilities (P ≥ 0.19); the regression slope of the observed probability on the predicted probability was 1.10/1.02, and the intercept was -0.04/0.06, respectively. A model without home SBP was also developed; for the 10-year home hypertension risk, the calibration test revealed a good concordance (P = 0.19) but Harrell's C-statistic was 0.6689 (0.6266-0.7067). CONCLUSIONS: The full model revealed good ability to predict the 5- and 10-year home morning hypertension risk. Although the model without home SBP is acceptable, the low C-statistic implies that home BP should be measured to predict home morning hypertension precisely.

  10. 地域医療連携システムを用いた専門医による治療アドバイスの予後改善効果の検討

    井戸 敬介, 井上 隆輔, 宮田 敏, 清水 宏明, 中山 雅晴

    医療情報学連合大会論文集 41回 891-893 2021/11

    Publisher: (一社)日本医療情報学会

    ISSN: 1347-8508

    eISSN: 2433-698X

  11. 家庭血圧に基づく高血圧発症10年予測モデル 大迫研究

    佐藤 倫広, 目時 弘仁, 浅山 敬, 菊谷 昌浩, 村上 任尚, 辰巳 友佳子, 原 梓, 廣瀬 卓男, 井上 隆輔, 野村 恭子, 寳澤 篤, 今井 潤, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集 43回 318-318 2021/10

    Publisher: (NPO)日本高血圧学会

  12. 家庭血圧に基づく高血圧発症10年予測モデル 大迫研究

    佐藤 倫広, 目時 弘仁, 浅山 敬, 菊谷 昌浩, 村上 任尚, 辰巳 友佳子, 原 梓, 廣瀬 卓男, 井上 隆輔, 野村 恭子, 寳澤 篤, 今井 潤, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集 43回 318-318 2021/10

    Publisher: (NPO)日本高血圧学会

  13. 妊娠・分娩回数と脳血管動脈硬化性変化 大迫研究

    佐藤 和奏, 野村 恭子, 佐藤 倫広, 原 梓, 坪田 恵, 小林 雄紀, 村上 任尚, 戸恒 智子, 廣瀬 卓男, 辰巳 友佳子, 井上 隆輔, 浅山 敬, 菊谷 昌浩, 目時 弘仁, 寶澤 篤, 渡邊 博之, 今井 潤, 大久保 孝義

    東北公衆衛生学会誌 (70) 11-11 2021/07

    Publisher: 東北公衆衛生学会

    ISSN: 0915-549X

  14. Oral health-related quality of life is associated with the prevalence and development of depressive symptoms in older Japanese individuals: The Ohasama Study. International-journal

    Takashi Ohi, Takahisa Murakami, Takamasa Komiyama, Yoshitada Miyoshi, Kosei Endo, Takako Hiratsuka, Michihiro Satoh, Kei Asayama, Ryusuke Inoue, Masahiro Kikuya, Hirohito Metoki, Atsushi Hozawa, Yutaka Imai, Makoto Watanabe, Takayoshi Ohkubo, Yoshinori Hattori

    Gerodontology 39 (2) 204-212 2021/05/19

    DOI: 10.1111/ger.12557  

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    OBJECTIVE: This prospective study investigated the cross-sectional association between impaired oral health-related quality of life (OHRQoL) and the prevalence of depressive symptoms, and the longitudinal association between impaired OHRQoL and development of depressive symptoms among older adults. BACKGROUND: Previous studies have shown a relationship between poor oral health and depression among older adults; however, findings are inconsistent. MATERIALS AND METHODS: Participants were 669 community-dwelling older Japanese individuals aged≥55 years (mean: 67.8 ± 7.2 years). Data of 296 participants were used for longitudinal analyses. OHRQoL was evaluated using the Oral Impacts on Daily Performances scale. Impaired OHRQoL was defined as the presence of at least one impact on the scale. Depressive symptoms were assessed using the Japanese version of the Zung self-rating depression scale with a cut-off score of 40. RESULTS: The cross-sectional logistic regression model demonstrated that impaired OHRQoL was significantly associated with depressive symptoms (odds ratio [OR], 5.17; 95% confidence interval [CI], 2.99-8.95) independent of age, sex, body mass index, hypertension, cerebrovascular/cardiovascular disease, smoking, drinking alcohol, education, cognitive function, objective oral health (dentition status) and oral health behaviour (dental visit within 1 year). Similarly, impaired OHRQoL predicted the development of depressive symptoms within 4 years in a fully adjusted longitudinal model (OR, 6.00; 95% CI, 1.38-26.09). CONCLUSION: Impaired OHRQoL was identified as a potential comorbidity of depressive symptoms and a predictor for depressive disorder later in life. OHRQoL may be a useful clinical outcome for elder patients with regard to their mental and oral health.

  15. Validity of congenital malformation diagnoses in healthcare claims from a university hospital in Japan. International-journal

    Tomofumi Ishikawa, Gen Oyanagi, Taku Obara, Aoi Noda, Kei Morishita, Shuyu Takagi, Ryusuke Inoue, Hiroshi Kawame, Nariyasu Mano

    Pharmacoepidemiology and drug safety 30 (7) 975-978 2021/04/09

    DOI: 10.1002/pds.5244  

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    PURPOSE: This study aimed to assess the validity of diagnoses of congenital malformations (CMs) recorded in claims of a university hospital in Japan. METHODS: Congenital malformations were identified according to Code Q00-Q89 of the International Classification of Diseases, 10th revision. All the children who had been diagnosed with CMs based on their claims in 2015 and within 1 year from their birth month were selected for this study. The infants' medical records were considered as a gold standard. Positive predictive values (PPVs) for CMs were calculated. RESULTS: This study included 227 infants who had a CM diagnosis in their claims. Based on the algorithms established by the Quebec Pregnancy Cohort study group, the PPV for any CM was 90.7% and that for major CMs (MCMs) was 91.5%. Concerning MCMs of specific organ systems, those of the circulatory system (PPV 85.1%) were the most frequent, followed by cleft lip and cleft palate (PPV 100.0%), and other CMs of the digestive system (PPV 96.4%). Based on the EUROCAT classification, the PPV for any MCM was 88.5%. Specific MCMs reported in ≥20 infants were ventricular septal defect (PPV 96.0%), patent ductus arteriosus (PPV 72.7%) and cleft lip with or without cleft palate (PPV 100.0%). CONCLUSIONS: The PPVs for CMs in the Japanese administrative data were high enough to suggest that these data could be utilized for perinatal pharmacoepidemiological evaluations. The results were from a single center, and further validation studies are needed.

  16. Lifetime risk of stroke stratified by chronic kidney disease and hypertension in the general Asian population: the Ohasama study

    Shingo Nakayama, Michihiro Satoh, Hirohito Metoki, Takahisa Murakami, Kei Asayama, Azusa Hara, Takuo Hirose, Atsuhiro Kanno, Ryusuke Inoue, Megumi Tsubota-Utsugi, Masahiro Kikuya, Takefumi Mori, Atsushi Hozawa, Yutaka Imai, Takayoshi Ohkubo

    Hypertension Research 2021/03/19

    Publisher: Springer Science and Business Media LLC

    DOI: 10.1038/s41440-021-00635-z  

    ISSN: 0916-9636

    eISSN: 1348-4214

  17. 児の先天奇形に関するレセプト傷病名の妥当性評価

    石川 智史, 小原 拓, 大柳 元, 野田 あおい, 森下 啓, 高木 秀侑, 井上 隆輔, 川目 裕, 眞野 成康

    Journal of Epidemiology 31 (Suppl.) 131-131 2021/01

    Publisher: (一社)日本疫学会

    ISSN: 0917-5040

    eISSN: 1349-9092

  18. 児の先天奇形に関するレセプト傷病名の妥当性評価

    石川 智史, 小原 拓, 大柳 元, 野田 あおい, 森下 啓, 高木 秀侑, 井上 隆輔, 川目 裕, 眞野 成康

    Journal of Epidemiology 31 (Suppl.) 131-131 2021/01

    Publisher: (一社)日本疫学会

    ISSN: 0917-5040

    eISSN: 1349-9092

  19. Blood Pressure Phenotypes Defined by Ambulatory Blood Pressure Monitoring and Carotid Artery Changes in Community-Dwelling Older Japanese Adults: The Ohasama Study.

    Ayami Fujita, Azusa Hara, Masahiro Kikuya, Kei Asayama, Michihiro Satoh, Kaori Asakura, Yoriko Shintani, Shinya Uchida, Yuko Takatsuji, Takahisa Murakami, Takuo Hirose, Megumi Tsubota-Utsugi, Ryusuke Inoue, Kyoko Nomura, Hirohito Metoki, Atsushi Hozawa, Seiko Miyazaki, Yutaka Imai, Takayoshi Ohkubo

    The Tohoku journal of experimental medicine 252 (3) 269-279 2020/11

    DOI: 10.1620/tjem.252.269  

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    White coat hypertension is defined as elevated blood pressure in the office, but a normal blood pressure out-of-office, whereas masked hypertension is defined as elevated blood pressure in the office, but normal out-of-office blood pressure. The objective was to investigate the associations between these blood pressure phenotypes and carotid artery changes. Conventional blood pressure, ambulatory blood pressure, and carotid ultrasonography were evaluated in 851 Ohasama residents (31.8% men; mean age 66.3 years). The blood pressure phenotypes were defined by the ordinary thresholds (140/90 mmHg for conventional blood pressure, 135/85 mmHg for daytime blood pressure) and then by the 2017 American College of Cardiology/American Heart Association (ACC/AHA) thresholds for hypertension (130/80 mmHg for both conventional and daytime blood pressure), irrespective of antihypertensive medication treatment status. Blood pressure phenotypes were linearly associated with the mean intima-media thickness of the carotid artery in ascending order for sustained normal blood pressure, white coat hypertension, masked hypertension, and sustained hypertension according to the ordinary thresholds and the 2017 ACC/AHA thresholds (both linear trends P < 0.0001) after adjustments for possible confounding factors. The odds ratios for the presence of carotid plaques showed similar linear trends with the blood pressure phenotypes according to the 2017 ACC/AHA thresholds (linear trend P < 0.0191). In conclusion, there was a close relationship between blood pressure phenotypes and carotid artery changes, suggesting that blood pressure phenotypes as defined by ambulatory blood pressure are potentially useful for risk stratification of carotid artery changes in the Japanese general population.

  20. CORRIGENDUM: N-Terminal Pro-B-Type Natriuretic Peptide Is a Predictor of Chronic Kidney Disease in an Asian General Population - The Ohasama Study.

    Shingo Nakayama, Michihiro Satoh, Hirohito Metoki, Takahisa Murakami, Kei Asayama, Azusa Hara, Takuo Hirose, Ryusuke Inoue, Megumi Tsubota-Utsugi, Masahiro Kikuya, Takefumi Mori, Atsushi Hozawa, Koichi Node, Yutaka Imai, Takayoshi Ohkubo

    Circulation reports 2 (7) 384-384 2020/07/10

    DOI: 10.1253/circrep.CR-66-0006  

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    [This corrects the article DOI: 10.1253/circrep.CR-19-0044.].

  21. 慢性腎臓病と高血圧の脳卒中発症生涯リスク 大迫研究

    中山 晋吾, 佐藤 倫広, 目時 弘仁, 村上 任尚, 浅山 敬, 原 梓, 廣瀬 卓男, 菅野 厚博, 井上 隆輔, 坪田 恵, 菊谷 昌浩, 森 建文, 寳澤 篤, 今井 潤, 大久保 孝義

    日本腎臓学会誌 62 (4) 302-302 2020/07

    Publisher: (一社)日本腎臓学会

    ISSN: 0385-2385

    eISSN: 1884-0728

  22. 慢性腎臓病と高血圧の脳卒中発症生涯リスク 大迫研究

    中山 晋吾, 佐藤 倫広, 目時 弘仁, 村上 任尚, 浅山 敬, 原 梓, 廣瀬 卓男, 菅野 厚博, 井上 隆輔, 坪田 恵, 菊谷 昌浩, 森 建文, 寳澤 篤, 今井 潤, 大久保 孝義

    日本腎臓学会誌 62 (4) 302-302 2020/07

    Publisher: (一社)日本腎臓学会

    ISSN: 0385-2385

    eISSN: 1884-0728

  23. 抗炎症作用を有する食事と高次生活機能低下との関連 大迫研究

    佐藤 桂子, 今井 絵理, 坪田 恵[宇津木], 佐藤 倫広, 村上 任尚, 辰巳 友佳子, 井上 隆輔, 浅山 敬, 菊谷 昌浩, 野村 恭子, 目時 弘仁, 寶澤 篤, 今井 潤, 大久保 孝義

    日本栄養・食糧学会大会講演要旨集 74回 240-240 2020/04

    Publisher: (公社)日本栄養・食糧学会

  24. 抗炎症作用を有する食事と高次生活機能低下との関連 大迫研究

    佐藤 桂子, 今井 絵理, 坪田 恵[宇津木], 佐藤 倫広, 村上 任尚, 辰巳 友佳子, 井上 隆輔, 浅山 敬, 菊谷 昌浩, 野村 恭子, 目時 弘仁, 寶澤 篤, 今井 潤, 大久保 孝義

    日本栄養・食糧学会大会講演要旨集 74回 240-240 2020/04

    Publisher: (公社)日本栄養・食糧学会

  25. 重度歯周病罹患歯の保有数と血圧との関連 大迫研究

    村上 任尚, 佐藤 倫広, 小宮山 貴将, 大井 孝, 遠藤 耕生, 平塚 貴子, 浅山 敬, 菊谷 昌浩, 井上 隆輔, 坪田 恵, 目時 弘仁, 寳澤 篤, 今井 潤, 服部 佳功, 大久保 孝義

    日本衛生学雑誌 75 (Suppl.) S161-S161 2020/03

    Publisher: (一社)日本衛生学会

    ISSN: 0021-5082

    eISSN: 1882-6482

  26. 重度歯周病罹患歯の保有数と血圧との関連 大迫研究 Peer-reviewed

    村上 任尚, 佐藤 倫広, 小宮山 貴将, 大井 孝, 遠藤 耕生, 平塚 貴子, 浅山 敬, 菊谷 昌浩, 井上 隆輔, 坪田 恵, 目時 弘仁, 寳澤 篤, 今井 潤, 服部 佳功, 大久保 孝義

    日本衛生学雑誌 75 (Suppl.) S161-S161 2020/03

    Publisher: (一社)日本衛生学会

    ISSN: 0021-5082

    eISSN: 1882-6482

  27. N-Terminal Pro-B-Type Natriuretic Peptide Is a Predictor of Chronic Kidney Disease in an Asian General Population - The Ohasama Study.

    Shingo Nakayama, Michihiro Satoh, Hirohito Metoki, Takahisa Murakami, Kei Asayama, Azusa Hara, Takuo Hirose, Ryusuke Inoue, Megumi Tsubota-Utsugi, Masahiro Kikuya, Takefumi Mori, Atsushi Hozawa, Koichi Node, Yutaka Imai, Takayoshi Ohkubo

    Circulation reports 2 (1) 24-32 2019/12/11

    DOI: 10.1253/circrep.CR-19-0044  

    More details Close

    Background: N-terminal pro-B-type natriuretic peptide (NT-proBNP) is known to increase in heart failure patients. Given that no reports have described the association between NT-proBNP and chronic kidney disease (CKD) incidence in Asian populations, we investigated this association in the Japanese population. Methods and Results: We followed up 867 participants without CKD from the general population of Ohasama, Japan. We defined CKD as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 and/or proteinuria. In accordance with previous studies, the participants were classified into 4 groups according to NT-proBNP level (<30.0, 30.0-54.9, 55.0-124.9, and ≥125.0 pg/mL). The Cox model was applied to assess adjusted hazard ratios (HR) for CKD incidence after full adjustment including baseline eGFR. Participant mean age was 59.1 years, and 587 (67.7%) were women. During the mean follow-up period of 9.7 years, 177 participants developed CKD. When the group with NT-proBNP <30.0 pg/mL was used as the reference, adjusted HR for CKD incidence in the 30.0-54.9, 55.0-124.9, and ≥125.0 pg/mL groups were 1.34 (95% CI: 0.90-2.01), 1.25 (95% CI: 0.81-1.92), and 1.83 (95% CI: 1.05-3.18), respectively. Conclusions: NT-proBNP can be significantly predictive for CKD incidence in Asian populations.

  28. 本態性高血圧患者における治療前および降圧治療中の家庭血圧指標の予後予測能 HOMED-BP研究 Peer-reviewed

    渡部 大介, 浅山 敬, 花澤 智大, 保坂 実樹, 佐藤 倫広, 安井 大策, 小原 拓, 井上 隆輔, 目時 弘仁, 菊谷 昌浩, 今井 潤, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集 42回 223-223 2019/10

    Publisher: (NPO)日本高血圧学会

  29. Association of Office and Ambulatory Blood Pressure With Mortality and Cardiovascular Outcomes

    Wen-Yi Yang, Jesus D. Melgarejo, Lutgarde Thijs, Zhen-Yu Zhang, Jose Boggia, Fang-Fei Wei, Tine W. Hansen, Kei Asayama, Takayoshi Ohkubo, Jorgen Jeppesen, Eamon Dolan, Katarzyna Stolarz-Skrzypek, Sofia Malyutina, Edoardo Casiglia, Lars Lind, Jan Filipovsky, Gladys E. Maestre, Yan Li, Ji-Guang Wang, Yutaka Imai, Kalina Kawecka-Jaszcz, Edgardo Sandoya, Krzysztof Narkiewicz, Eoin O'Brien, Peter Verhamme, Jan A. Staessen, B. Mujaj, N. Cauwenberghs, T. Kuznetsova, W. -Y. Yang, C. -G. Yu, C. -S. Sheng, Q. -F. Huang, J. Seidlerova, M. Ticha, H. Ibsen, S. Rasmussen, C. Torp-Pedersen, A. Pizzioli, V. Tikhonoff, J. Hashimoto, H. Hoshi, R. Inoue, M. Kikuya, H. Metoki, T. Obara, H. Satoh, K. Totsune, N. Gilis-Malinowska, A. Adamkiewicz-Piejko, M. Cwynar, J. Gasowski, T. Grodzicki, W. Lubaszewski, A. Olszanecka, B. Wizner, W. Wojciechowska, J. Zyczkowska, Y. Nikitin, E. Pello, G. Simonova, M. Voevoda, B. Andren, L. Berglund, K. Bjorklund-Bodegard, B. Zethelius, M. Bianchi, V. Moreira, C. Schettini, E. Schwedt, H. Senra

    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 322 (5) 409-420 2019/08

    DOI: 10.1001/jama.2019.9811  

    ISSN: 0098-7484

    eISSN: 1538-3598

  30. Age-Related Trends in Home Blood Pressure, Home Pulse Rate, and Day-to-Day Blood Pressure and Pulse Rate Variability Based on Longitudinal Cohort Data: The Ohasama Study. Peer-reviewed

    Satoh M, Metoki H, Asayama K, Murakami T, Inoue R, Tsubota-Utsugi M, Matsuda A, Hirose T, Hara A, Obara T, Kikuya M, Nomura K, Hozawa A, Imai Y, Ohkubo T

    Journal of the American Heart Association 8 (15) e012121 2019/08

    DOI: 10.1161/JAHA.119.012121  

  31. Development and evaluation of a home nocturnal blood pressure monitoring system using a wrist-cuff device. Peer-reviewed

    Imai Y, Asayama K, Fujiwara S, Saito K, Sato H, Haga T, Satoh M, Murakami T, Metoki H, Kikuya M, Obara T, Inoue R, Ohkubo T

    Blood pressure monitoring 23 (6) 318-326 2018/12

    DOI: 10.1097/MBP.0000000000000351  

    ISSN: 1359-5237

  32. Predictive power of home blood pressure indices at baseline and during follow-up in hypertensive patients: HOMED-BP study. Peer-reviewed

    Watabe D, Asayama K, Hanazawa T, Hosaka M, Satoh M, Yasui D, Obara T, Inoue R, Metoki H, Kikuya M, Imai Y, Ohkubo T, Hypertension Objective Treatment, Based on Measurement, by Electrical Devices of, Blood Pressure, HOMED-BP) investigators

    Hypertension research : official journal of the Japanese Society of Hypertension 41 (8) 622-628 2018/08

    DOI: 10.1038/s41440-018-0050-4  

    ISSN: 0916-9636

  33. Association between tooth loss and cognitive impairment in community-dwelling older Japanese adults: a 4-year prospective cohort study from the Ohasama study. Peer-reviewed

    Saito S, Ohi T, Murakami T, Komiyama T, Miyoshi Y, Endo K, Satoh M, Asayama K, Inoue R, Kikuya M, Metoki H, Imai Y, Ohkubo T, Hattori Y

    BMC oral health 18 (1) 142 2018/08

    Publisher: Springer Science and Business Media LLC

    DOI: 10.1186/s12903-018-0602-7  

    eISSN: 1472-6831

  34. Development of algorithms to determine the onset of pregnancy and delivery date using health care administrative data in a university hospital in Japan. Peer-reviewed

    Ishikawa T, Obara T, Nishigori H, Miyakoda K, Inoue R, Hoshiai T, Saito M, Yaegashi N, Mano N

    Pharmacoepidemiology and drug safety 27 (7) 751-762 2018/07

    DOI: 10.1002/pds.4444  

    ISSN: 1053-8569

  35. N-Terminal Pro-B-Type Natriuretic Peptide Is Not a Significant Predictor of Stroke Incidence After 5 Years - The Ohasama Study. Peer-reviewed

    Satoh M, Murakami T, Asayama K, Hirose T, Kikuya M, Inoue R, Tsubota-Utsugi M, Murakami K, Matsuda A, Hara A, Obara T, Kawasaki R, Nomura K, Metoki H, Node K, Imai Y, Ohkubo T

    Circulation journal : official journal of the Japanese Circulation Society 82 (8) 2055-2062 2018/07

    DOI: 10.1253/circj.CJ-17-1227  

    ISSN: 1346-9843

  36. Association Between Amplitude of Seasonal Variation in Self-Measured Home Blood Pressure and Cardiovascular Outcomes: HOMED-BP (Hypertension Objective Treatment Based on Measurement By Electrical Devices of Blood Pressure) Study. Peer-reviewed

    Hanazawa T, Asayama K, Watabe D, Tanabe A, Satoh M, Inoue R, Hara A, Obara T, Kikuya M, Nomura K, Metoki H, Imai Y, Ohkubo T, HOMED‐BP (Hypertension, Objective Treatment, Based on Measurement, by Electrical Devices of, Blood, Pressure) Investigators

    Journal of the American Heart Association 7 (10) 2018/05

    DOI: 10.1161/JAHA.117.008509  

  37. Genome-wide association study for white coat effect in Japanese middle-aged to elderly people: The HOMED-BP study. Peer-reviewed

    Ogata S, Kamide K, Asayama K, Tabara Y, Kawaguchi T, Satoh M, Katsuya T, Sugimoto K, Hirose T, Inoue R, Hara A, Obara T, Kikuya M, Metoki H, Matsuda F, Staessen JA, Ohkubo T, Rakugi H, Imai Y

    Clinical and experimental hypertension (New York, N.Y. : 1993) 40 (4) 363-369 2018

    DOI: 10.1080/10641963.2017.1384481  

    ISSN: 1064-1963

  38. Effect of amlodipine, efonidipine, and trichlormethiazide on home blood pressure and upper-normal microalbuminuria assessed by casual spot urine test in essential hypertensive patients. Peer-reviewed

    Hosaka M, Inoue R, Satoh M, Watabe D, Hanazawa T, Ohkubo T, Asayama K, Obara T, Imai Y, J-HOME-ALB Study group

    Clinical and experimental hypertension (New York, N.Y. : 1993) 40 (5) 468-475 2018

    DOI: 10.1080/10641963.2017.1403617  

    ISSN: 1064-1963

  39. Nocturnal blood pressure decline based on different time intervals and long-term cardiovascular risk: the Ohasama Study. Peer-reviewed

    Satoh M, Asayama K, Kikuya M, Inoue R, Tsubota-Utsugi M, Obara T, Murakami K, Matsuda A, Murakami T, Nomura K, Metoki H, Imai Y, Ohkubo T

    Clinical and experimental hypertension (New York, N.Y. : 1993) 40 (1) 1-7 2018

    DOI: 10.1080/10641963.2016.1259324  

    ISSN: 1064-1963

  40. Psychometric validation of a new measurement instrument for time-oriented patient information in electronic medical records: A questionnaire survey of physicians Peer-reviewed

    Akiko Shibuya, Jimpei Misawa, Yukihiro Maeda, Rie Ichikawa, Michiyo Kamata, Ryusuke Inoue, Tetsuji Morimoto, Masaharu Nakayama, Teruyoshi Hishiki, Yoshiaki Kondo

    JOURNAL OF EVALUATION IN CLINICAL PRACTICE 23 (6) 1459-1465 2017/12

    DOI: 10.1111/jep.12824  

    ISSN: 1356-1294

    eISSN: 1365-2753

  41. Home blood pressure predicts stroke incidence among older adults with impaired physical function: the Ohasama study. Peer-reviewed

    Murakami K, Asayama K, Satoh M, Hosaka M, Matsuda A, Inoue R, Tsubota-Utsugi M, Murakami T, Nomura K, Kikuya M, Metoki H, Imai Y, Ohkubo T

    Journal of hypertension 35 (12) 2395-2401 2017/12

    DOI: 10.1097/HJH.0000000000001473  

    ISSN: 0263-6352

  42. eXChartを用いた診療情報の利用

    佐藤 佳奈子, 末永 洋子, 井上 隆輔, 中村 直毅, 中山 雅晴

    医療情報学連合大会論文集 37回 1046-1048 2017/11

    Publisher: (一社)日本医療情報学会

    ISSN: 1347-8508

    eISSN: 2433-698X

  43. Risk Factors for Stroke among Young-Old and Old-Old Community-Dwelling Adults in Japan: The Ohasama Study. Peer-reviewed

    Murakami K, Asayama K, Satoh M, Inoue R, Tsubota-Utsugi M, Hosaka M, Matsuda A, Nomura K, Murakami T, Kikuya M, Metoki H, Imai Y, Ohkubo T

    Journal of atherosclerosis and thrombosis 24 (3) 290-300 2017/03

    Publisher: Japan Atherosclerosis Society

    DOI: 10.5551/jat.35766  

    ISSN: 1340-3478

    More details Close

    <p>Aim: Few studies have addressed stroke risk factors in older populations, particularly among the old-old. We examined differences in traditional risk factors for stroke among the old-old compared with the young-old in community-dwelling Japanese adults.</p><p>Methods: We followed 2,065 residents aged ≥ 60 years who had no history of stroke. Traditional risk factors for stroke were obtained from a self-administered questionnaire at baseline. We classified participants into two age categories, 60–74 years (n=1,502) and ≥ 75 years (n=563), and assessed whether traditional risk factors were differentially associated with stroke incidence according to age category. Hazard ratios were calculated by the Cox proportional hazards model, adjusting for confounding factors and competing risk of death.</p><p>Results: During a median follow-up of 12.8 and 7.9 years, 163 and 111 participants aged 60–74 and ≥ 75 years, respectively, developed a first stroke. Hypertension was consistently associated with increased risk of stroke, regardless of age category. Diabetes mellitus was associated with increased risk of stroke in those aged 60–74 years (hazard ratio, 1.50; 95% confidence interval, 1.00–2.25), but not in those aged ≥ 75 years (hazard ratio, 0.65; 95% confidence interval, 0.33–1.29), with significant interaction by age (P=0.035). No traditional risk factor other than hypertension was associated with stroke among those aged ≥ 75 years.</p><p>Conclusion: Those with hypertension had significantly higher stroke risk among old people, while diabetes mellitus was differentially associated with stroke according to age category. Our findings indicate the importance of different prevention strategies for stroke incidence according to age category.</p>

  44. Seasonal variation in self-measured home blood pressure among patients on antihypertensive medications: HOMED-BP study. Peer-reviewed

    Hanazawa T, Asayama K, Watabe D, Hosaka M, Satoh M, Yasui D, Obara T, Inoue R, Metoki H, Kikuya M, Imai Y, Ohkubo T

    Hypertension research : official journal of the Japanese Society of Hypertension 40 (3) 284-290 2017/03

    DOI: 10.1038/hr.2016.133  

    ISSN: 0916-9636

  45. Lacunar Infarcts Rather than White Matter Hyperintensity as a Predictor of Future Higher Level Functional Decline: The Ohasama Study. Peer-reviewed

    Tsubota-Utsugi M, Satoh M, Tomita N, Hara A, Kondo T, Hosaka M, Saito S, Asayama K, Inoue R, Hirano M, Hosokawa A, Murakami K, Murakami T, Metoki H, Kikuya M, Izumi SI, Imai Y, Ohkubo T

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 26 (2) 376-384 2017/02

    DOI: 10.1016/j.jstrokecerebrovasdis.2016.09.036  

    ISSN: 1052-3057

  46. Trends in Antihypertensive Drug Prescriptions Based on Claims Data in a Japanese Hospital

    Satoh Michihiro, Kurosawa Keiko, Obara Taku, Matsuura Masaki, Inoue Ryusuke, Takahashi Nobuyuki, Sato Hiroshi, Murai Yuriko, Mano Nariyasu

    Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) 43 (1) 9-17 2017

    Publisher: 一般社団法人日本医療薬学会

    ISSN: 1346-342X

    eISSN: 1882-1499

  47. Reference values and associated factors for Japanese newborns' blood pressure and pulse rate: the babies' and their parents' longitudinal observation in Suzuki Memorial Hospital on intrauterine period (BOSHI) study. Peer-reviewed

    Satoh M, Inoue R, Tada H, Hosaka M, Metoki H, Asayama K, Murakami T, Mano N, Ohkubo T, Yagihashi K, Hoshi K, Suzuki M, Imai Y

    Journal of hypertension 34 (8) 1578-1585 2016/08

    DOI: 10.1097/HJH.0000000000000976  

    ISSN: 0263-6352

  48. The velocity of antihypertensive effects of seven angiotensin II receptor blockers determined by home blood pressure measurements. Peer-reviewed

    Satoh M, Haga T, Hosaka M, Obara T, Metoki H, Murakami T, Kikuya M, Inoue R, Asayama K, Mano N, Ohkubo T, Imai Y

    Journal of hypertension 34 (6) 1218-1223 2016/06

    DOI: 10.1097/HJH.0000000000000902  

    ISSN: 0263-6352

  49. Maternal clinic and home blood pressure measurements during pregnancy and infant birth weight: The BOSHI study

    Noriyuki Iwama, Hirohito Metoki, Takayoshi Ohkubo, Mami Ishikuro, Taku Obara, Masahiro Kikuya, Katsuyo Yagihashi, Hidekazu Nishigori, Takashi Sugiyama, Junichi Sugawara, Nobuo Yaegashi, Kazuhiko Hoshi, Masakuni Suzuki, Shinichi Kuriyama, Yutaka Imai, Kohei Tanaka, Kunihiko Okamura, Kei Asayama, Ryusuke Inoue, Rie Tsuchida, Azusa Hara, Takuo Hirose, Takeshi Kobayashi, Kenta Gonokami, Takanao Hashimoto, Yumiko Watanabe, Misato Nishimura, Maiko Kawaguchi, Yurie Sato, Minako Hoshikawa, Ayano Sasaki, Kasumi Sakurai, Michihiro Sato, Konomi Akutsu, Mami Yamamoto, Aya Shiraishi, Miki Hosaka, Ikuo Tachibana, Maki Omura, Mikiko Ishikawa, Yoshimi Fujii, Hidemi Kobayashi, Kazuyuki Akaishi, Yuko Kikuchi, Kei Tate, Chieko Koishi, Saori Sugawara, Junko Saitou, Hiromi Sasaki, Tomoko Suzuki, Junko Takahashi, Yoko Narita, Satoko Shigihara, Hideko Tada, Yumi Hamada, Nozomi Satou, Nami Satou, Setsuko Sai, Nana Atsumi, Naoko Sekine, Yukari Ueno, Yu Itou, Yukie Obara, Nami Onodera, Asako Sato, Youko Iwasa, Mamiko Abe, Yukari Kido, Risako Komuro, Yukiko Nakamura, Marie Watanabe, Chikako Matsumoto, Koto Oyama, Aya Takahashi, Michiko Kojima, Miyuki Abe, Mariko Sane, Mana Takahashi, Kana Sugata Miho Igari, Haruhi Sasaki, Mizuki Kobayashi, Aya Kikuchi, Risa Yamamoto, Akiho Goto, Eri Yamauchi, Mika Chiba, Sakiko Ota, Hiromi Ishikawa, Akemi Sasaki, Tomoko Kawamura, Hiroko Hiji, Misaki Kishinami, Yurie Kowata, Eiko Yamauchi, Yasuko Takahashi, Naho Sato, The BOSHI Study Group

    Hypertension Research 39 (3) 151-157 2016/03/01

    Publisher: Nature Publishing Group

    DOI: 10.1038/hr.2015.108  

    ISSN: 1348-4214 0916-9636

  50. Impaired Higher-Level Functional Capacity as a Predictor of Stroke in Community-Dwelling Older Adults: The Ohasama Study. Peer-reviewed

    Murakami K, Tsubota-Utsugi M, Satoh M, Asayama K, Inoue R, Ishiguro A, Matsuda A, Kanno A, Yasui D, Murakami T, Metoki H, Kikuya M, Imai Y, Ohkubo T

    Stroke 47 (2) 323-328 2016/02

    DOI: 10.1161/STROKEAHA.115.011131  

    ISSN: 0039-2499

  51. Menstrual Factors and Stroke Incidence in Japanese Postmenopausal Women: The Ohasama Study. Peer-reviewed

    Murakami K, Metoki H, Satoh M, Asayama K, Hosaka M, Matsuda A, Inoue R, Tsubota-Utsugi M, Murakami T, Nomura K, Kikuya M, Imai Y, Ohkubo T

    Neuroepidemiology 47 (2) 109-116 2016

    DOI: 10.1159/000452220  

    ISSN: 0251-5350

  52. Long-Term Stroke Risk Due to Partial White-Coat or Masked Hypertension Based on Home and Ambulatory Blood Pressure Measurements: The Ohasama Study. Peer-reviewed

    Satoh M, Asayama K, Kikuya M, Inoue R, Metoki H, Hosaka M, Tsubota-Utsugi M, Obara T, Ishiguro A, Murakami K, Matsuda A, Yasui D, Murakami T, Mano N, Imai Y, Ohkubo T

    Hypertension 67 (1) 48-55 2015/11

    DOI: 10.1161/HYPERTENSIONAHA.115.06461  

    ISSN: 0194-911X

  53. Randomized trial comparing the velocities of the antihypertensive effects on home blood pressure of candesartan and candesartan with hydrochlorothiazide. Peer-reviewed

    Hosaka M, Metoki H, Satoh M, Ohkubo T, Asayama K, Kikuya M, Inoue R, Obara T, Hirose T, Imai Y

    Hypertension research : official journal of the Japanese Society of Hypertension 38 (10) 701-707 2015/10

    DOI: 10.1038/hr.2015.64  

    ISSN: 0916-9636

  54. Association between N-terminal pro B-type natriuretic peptide and day-to-day blood pressure and heart rate variability in a general population: the Ohasama study. Peer-reviewed

    Satoh M, Hosaka M, Asayama K, Kikuya M, Inoue R, Metoki H, Tsubota-Utsugi M, Hara A, Hirose T, Obara T, Totsune K, Hoshi H, Mano N, Node K, Imai Y, Ohkubo T

    Journal of hypertension 33 (8) 1536-1541 2015/08

    DOI: 10.1097/HJH.0000000000000570  

    ISSN: 0263-6352

  55. Living situations associated with poor dietary intake among healthy Japanese elderly: the Ohasama Study. Peer-reviewed

    Tsubota-Utsugi M, Kikuya M, Satoh M, Inoue R, Hosaka M, Metoki H, Hirose T, Asayama K, Imai Y, Ohkubo T

    The journal of nutrition, health & aging 19 (4) 375-382 2015/04

    DOI: 10.1007/s12603-015-0456-5  

    ISSN: 1279-7707

  56. Mapping the genetic diversity of HLA haplotypes in the Japanese populations Peer-reviewed

    Saw W.-Y, Liu X, Khor C.-C, Takeuchi F, Katsuya T, Kimura R, Nabika T, Ohkubo T, Tabara Y, Yamamoto K, Yokota M, Akiyama K, Asano H, Asayama K, Haga T, Hara A, Hirose T, Hosaka M, Ichihara S, Imai Y, Inoue R, Ishiguro A, Isomura M, Isono M, Kamide K, Kato N, Kikuya M, Kohara K, Matsubara T, Matsuda A, Metoki H, Miki T, Murakami K, Nakatochi M, Ogihara T, Ohnaka K, Rakugi H, Satoh M, Shiwaku K, Sugimoto K, Takami Y, Takayanagi R, Tsubota-Utsugi M, Yamamoto K, Yamasaki M, Yasui D, Teo Y.-Y

    Scientific Reports 5 2015

    Publisher: Nature Publishing Group

    DOI: 10.1038/srep17855  

    ISSN: 2045-2322

  57. Association of Aldosterone-to-Renin Ratio With Hypertension Differs by Sodium Intake: The Ohasama Study. Peer-reviewed

    Satoh M, Kikuya M, Hosaka M, Asayama K, Inoue R, Metoki H, Tsubota-Utsugi M, Hara A, Hirose T, Obara T, Mori T, Totsune K, Hoshi H, Mano N, Imai Y, Ohkubo T

    American journal of hypertension 28 (2) 208-215 2014/06

    DOI: 10.1093/ajh/hpu115  

    ISSN: 0895-7061

  58. Day-to-day variability in home blood pressure is associated with cognitive decline: the Ohasama study. Peer-reviewed

    Matsumoto A, Satoh M, Kikuya M, Ohkubo T, Hirano M, Inoue R, Hashimoto T, Hara A, Hirose T, Obara T, Metoki H, Asayama K, Hosokawa A, Totsune K, Hoshi H, Hosokawa T, Sato H, Imai Y

    Hypertension 63 1333-1338 2014/06

    Publisher: 6

    DOI: 10.1161/HYPERTENSIONAHA.113.01819  

    ISSN: 0194-911X

  59. Conformational Change in Transfer RNA Is an Early Indicator of Acute Cellular Damage. Peer-reviewed

    Mishima E, Inoue C, Saigusa D, Inoue R, Ito K, Suzuki Y, Jinno D, Tsukui Y, Akamatsu Y, Araki M, Araki K, Shimizu R, Shinke H, Suzuki T, Takeuchi Y, Shima H, Akiyama Y, Toyohara T, Suzuki C, Saiki Y, Tominaga T, Miyagi S, Kawagisihi N, Soga T, Ohkubo T, Yamamura K, Imai Y, Masuda S, Sabbisetti V, Ichimura T, Mount DB, Bonventre JV, Ito S, Tomioka Y, Itoh K, Abe T

    Journal of the American Society of Nephrology : JASN 25 (10) 2316-2326 2014/05

    DOI: 10.1681/ASN.2013091001  

    ISSN: 1046-6673

  60. Animal protein intake is associated with higher-level functional capacity in elderly adults: the Ohasama study. Peer-reviewed

    Imai E, Tsubota-Utsugi M, Kikuya M, Satoh M, Inoue R, Hosaka M, Metoki H, Fukushima N, Kurimoto A, Hirose T, Asayama K, Imai Y, Ohkubo T

    Journal of the American Geriatrics Society 62 (3) 426-434 2014/03

    Publisher: 3

    DOI: 10.1111/jgs.12690  

    ISSN: 0002-8614

  61. The Need for Standardization of Allergy Information in Electronic Medical Record among Japanese Hospitals Peer-reviewed

    Masaharu Nakayama, Ryusuke Inoue

    Studies in Health Technology and Informatics 205 1257 2014

    Publisher: IOS Press

    DOI: 10.3233/978-1-61499-432-9-1257  

    ISSN: 1879-8365 0926-9630

  62. Personality traits as predictors of decline in higher-level functional capacity over a 7-year follow-up in older adults: the Ohasama study. Peer-reviewed

    Tsubota-Utsugi M, Satoh M, Hosaka M, Inoue R, Asayama K, Hirose T, Metoki H, Kikuya M, Imai Y, Ohkubo T

    The Tohoku journal of experimental medicine 234 (3) 197-207 2014

    Publisher: Tohoku University Medical Press

    DOI: 10.1620/tjem.234.197  

    ISSN: 0040-8727

    More details Close

    Numerous factors that affect functional decline have been identified, and personality traits are considered to be an important factor in functional decline risk. The Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG) was developed to measure three higher-level functional capacities, instrumental activities of daily living, intellectual activity, and social roles, in Japanese elderly, which were previously not assessed adequately with existing scales of functional decline. The objective of this study was to explore the effect of personality traits as predictors of higher-level functional decline over a 7-year follow-up in a rural Japanese community. Data on 676 participants (mean 67.1 years) who were free of functional decline and had completed questionnaires at baseline and 7 years later, were analyzed. Demographic characteristics, lifestyle and personality characteristics were obtained from a self-administered questionnaire at baseline. Higher-level functional decline was examined using the subscales of the TMIG at baseline and at a 7-year follow-up examination. Over the 7-year study period, 21.7% of eligible participants reported decline in higher-level functional capacity. After adjustment for putative confounding factors, the traits that were significant predictors of decline in higher-level functional capacity at the 7-year follow-up had higher psychoticism scores [odds ratio (95% confidence interval) 2.12 (1.23-3.66)] and lower extraversion scores [1.89 (1.01-3.56)]. The personality traits of higher psychoticism and lower extraversion were significantly associated with a risk of future functional decline. A better understanding of these personality traits may help identify of at-risk individuals and could help reduce functional decline in older adults.

  63. Aldosterone-to-renin ratio and nocturnal blood pressure decline assessed by self-measurement of blood pressure at home: the Ohasama Study. Peer-reviewed

    Satoh M, Hosaka M, Asayama K, Kikuya M, Inoue R, Metoki H, Utsugi MT, Hara A, Hirose T, Obara T, Mori T, Totsune K, Hoshi H, Mano N, Imai Y, Ohkubo T

    Clinical and experimental hypertension (New York, N.Y. : 1993) 36 108-114 2014

    Publisher: 2

    DOI: 10.3109/10641963.2014.892121  

    ISSN: 1064-1963

  64. Night-time blood pressure is associated with the development of chronic kidney disease in a general population: the Ohasama Study. Peer-reviewed

    Kanno A, Kikuya M, Asayama K, Satoh M, Inoue R, Hosaka M, Metoki H, Obara T, Hoshi H, Totsune K, Sato T, Taguma Y, Sato H, Imai Y, Ohkubo T

    Journal of hypertension 31 2410-2417 2013/12

    Publisher: 12

    DOI: 10.1097/HJH.0b013e328364dd0f  

    ISSN: 0263-6352

  65. Genome-wide response to antihypertensive medication using home blood pressure measurements: a pilot study nested within the HOMED-BP study. Peer-reviewed

    Kamide K, Asayama K, Katsuya T, Ohkubo T, Hirose T, Inoue R, Metoki H, Kikuya M, Obara T, Hanada H, Thijs L, Kuznetsova T, Noguchi Y, Sugimoto K, Ohishi M, Morimoto S, Nakahashi T, Takiuchi S, Ishimitsu T, Tsuchihashi T, Soma M, Higaki J, Matsuura H, Shinagawa T, Sasaguri T, Miki T, Takeda K, Shimamoto K, Ueno M, Hosomi N, Kato J, Komai N, Kojima S, Sase K, Miyata T, Tomoike H, Kawano Y, Ogihara T, Rakugi H, Staessen JA, Imai Y, GEANE study group, HOMED-BP study group

    Pharmacogenomics 14 (14) 1709-1721 2013/11

    DOI: 10.2217/PGS.13.161  

    ISSN: 1462-2416

    eISSN: 1744-8042

  66. Breastfeeding leads to lower blood pressure in 7-year-old Japanese children: Tohoku Study of Child Development (vol 36, pg 117, 2012) Peer-reviewed

    Hosaka Miki, Asayama Kei, Staessen Jan A, Ohkubo Takayoshi, Hayashi Katsuhisa, Tatsuta Nozomi, Kurokawa Naoyuki, Satoh Michihiro, Hashimoto Takanao, Hirose Takuo, Obara Taku, Metoki Hirohito, Inoue Ryusuke, Kikuya Masahiro, Nakai Kunihiko, Imai Yutaka, Satoh Hiroshi

    HYPERTENSION RESEARCH 36 (2) 184 2013/02

    DOI: 10.1038/hr.2012.203  

    ISSN: 0916-9636

  67. Breastfeeding leads to lower blood pressure in 7-year-old Japanese children: Tohoku Study of Child Development. Peer-reviewed

    Hosaka M, Asayama K, Staessen JA, Ohkubo T, Hayashi K, Tatsuta N, Kurokawa N, Satoh M, Hashimoto T, Hirose T, Obara T, Metoki H, Inoue R, Kikuya M, Nakai K, Imai Y, Satoh H

    Hypertension research : official journal of the Japanese Society of Hypertension 36 117-122 2013/02

    Publisher: 2

    DOI: 10.1038/hr.2012.128  

    ISSN: 0916-9636

  68. Home blood pressure variability as cardiovascular risk factor in the population of Ohasama. Peer-reviewed

    Asayama K, Kikuya M, Schutte R, Thijs L, Hosaka M, Satoh M, Hara A, Obara T, Inoue R, Metoki H, Hirose T, Ohkubo T, Staessen JA, Imai Y

    Hypertension 61 61-69 2013/01

    Publisher: 1

    DOI: 10.1161/HYPERTENSIONAHA.111.00138  

    ISSN: 0194-911X

  69. Cardiovascular outcomes in the first trial of antihypertensive therapy guided by self-measured home blood pressure. Peer-reviewed

    Asayama K, Ohkubo T, Metoki H, Obara T, Inoue R, Kikuya M, Thijs L, Staessen JA, Imai Y, Hypertension Objective Treatment, Based on Measurement, by Electrical Devices of, Blood Pressure, HOMED-BP

    Hypertension research : official journal of the Japanese Society of Hypertension 35 1102-1110 2012/11

    Publisher: 11

    DOI: 10.1038/hr.2012.125  

    ISSN: 0916-9636

  70. Mother-offspring aggregation in home versus conventional blood pressure in the Tohoku Study of Child Development (TSCD) Peer-reviewed

    Kei Asayama, Jan A. Staessen, Katsuhisa Hayashi, Miki Hosaka, Nozomi Tatsuta, Naoyuki Kurokawa, Michihiro Satoh, Takanao Hashimoto, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Masahiro Kikuya, Takayoshi Ohkubo, Kunihiko Nakai, Yutaka Imai, Hiroshi Satoh

    ACTA CARDIOLOGICA 67 (4) 449-456 2012/08

    DOI: 10.2143/AC.67.4.2170687  

    ISSN: 0001-5385

  71. Home Blood Pressure Level, Blood Pressure Variability, Smoking, and Stroke Risk in Japanese Men: The Ohasama Study Peer-reviewed

    Takanao Hashimoto, Masahiro Kikuya, Takayoshi Ohkubo, Michihiro Satoh, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Taku Obara, Takuo Hirose, Azusa Hara, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Hiroshi Sato, Yutaka Imai

    AMERICAN JOURNAL OF HYPERTENSION 25 (8) 883-891 2012/08

    DOI: 10.1038/ajh.2012.62  

    ISSN: 0895-7061

  72. Plasma renin activity and the aldosterone-to-renin ratio are associated with the development of chronic kidney disease: the Ohasama Study Peer-reviewed

    Shiho Terata, Masahiro Kikuya, Michihiro Satoh, Takayoshi Ohkubo, Takanao Hashimoto, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Hiroshi Sato, Yutaka Imai

    JOURNAL OF HYPERTENSION 30 (8) 1632-1638 2012/08

    DOI: 10.1097/HJH.0b013e328354f65b  

    ISSN: 0263-6352

  73. Pre-hypertension as a significant predictor of chronic kidney disease in a general population: the Ohasama Study Peer-reviewed

    Atsuhiro Kanno, Masahiro Kikuya, Takayoshi Ohkubo, Takanao Hashimoto, Michihiro Satoh, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Yoh Shishido, Haruhisa Hoshi, Masaaki Nakayama, Kazuhito Totsune, Hiroshi Satoh, Hiroshi Sato, Yutaka Imai

    NEPHROLOGY DIALYSIS TRANSPLANTATION 27 (8) 3218-3223 2012/08

    DOI: 10.1093/ndt/gfs054  

    ISSN: 0931-0509

  74. The velocity of antihypertensive effect of losartan/hydrochlorothiazide and angiotensin II receptor blocker Peer-reviewed

    Hirohito Metoki, Takayoshi Ohkubo, Masahiro Kikuya, Kei Asayama, Ryusuke Inoue, Taku Obara, Takuo Hirose, Michihiro Sato, Takanao Hashimoto, Yutaka Imai

    JOURNAL OF HYPERTENSION 30 (7) 1478-1486 2012/07

    DOI: 10.1097/HJH.0b013e328353f1fe  

    ISSN: 0263-6352

  75. Aldosterone-to-Renin Ratio as a Predictor of Stroke Under Conditions of High Sodium Intake: The Ohasama Study Peer-reviewed

    Michihiro Satoh, Masahiro Kikuya, Takayoshi Ohkubo, Takefumi Mori, Hirohito Metoki, Azusa Hara, Megumi T. Utsugi, Takanao Hashimoto, Takuo Hirose, Taku Obara, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    AMERICAN JOURNAL OF HYPERTENSION 25 (7) 777-783 2012/07

    DOI: 10.1038/ajh.2012.33  

    ISSN: 0895-7061

  76. Evaluating home blood pressure in treated hypertensives in comparison with the referential value of casual screening of blood pressure: the Ohasama study Peer-reviewed

    Daisaku Yasui, Kei Asayama, Noriko Takada, Takayoshi Ohkubo, Masahiro Kikuya, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Jan A. Staessen, Yutaka Imai

    BLOOD PRESSURE MONITORING 17 (3) 89-95 2012/06

    DOI: 10.1097/MBP.0b013e328351de34  

    ISSN: 1359-5237

    eISSN: 1473-5725

  77. Predictive Value for Mortality of the Double Product at Rest Obtained by Home Blood Pressure Measurement: The Ohasama Study Peer-reviewed

    Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Atsuhiro Kanno, Taku Obara, Takuo Hirose, Azusa Hara, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Yoshiaki Kondo, Yutaka Imai

    AMERICAN JOURNAL OF HYPERTENSION 25 (5) 568-575 2012/05

    DOI: 10.1038/ajh.2012.3  

    ISSN: 0895-7061

  78. Ambulatory Versus Home Versus Clinic Blood Pressure The Association With Subclinical Cerebrovascular Diseases: The Ohasama Study Peer-reviewed

    Azusa Hara, Kazushi Tanaka, Takayoshi Ohkubo, Takeo Kondo, Masahiro Kikuya, Hirohito Metoki, Takanao Hashimoto, Michihiro Satoh, Ryusuke Inoue, Kei Asayama, Taku Obara, Takuo Hirose, Shin-Ichi Izumi, Hiroshi Satoh, Yutaka Imai

    HYPERTENSION 59 (1) 22-U99 2012/01

    DOI: 10.1161/HYPERTENSIONAHA.111.174938  

    ISSN: 0194-911X

    eISSN: 1524-4563

  79. Prognostic Significance of Home Arterial Stiffness Index Derived From Self-Measurement of Blood Pressure: The Ohasama Study Peer-reviewed

    Masahiro Kikuya, Takayoshi Ohkubo, Michihiro Satoh, Takanao Hashimoto, Takuo Hirose, Hirohito Metoki, Taku Obara, Ryusuke Inoue, Kei Asayama, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Jan A. Staessen, Yutaka Imai

    AMERICAN JOURNAL OF HYPERTENSION 25 (1) 67-73 2012/01

    DOI: 10.1038/ajh.2011.167  

    ISSN: 0895-7061

  80. Validation of the Parama-Tech PS-501 Device for Office Blood Pressure Measurement According to the International Protocol Peer-reviewed

    Masahiro Kikuya, Takayoshi Ohkubo, Michihiro Satoh, Takanao Hashimoto, Takuo Hirose, Hirohito Metoki, Taku Obara, Ryusuke Inoue, Kei Asayama, Kazuhito Totsune, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION 34 (1) 71-73 2012

    DOI: 10.3109/10641963.2011.618198  

    ISSN: 1064-1963

  81. Influence of adrenomedullin 2/intermedin gene polymorphism on blood pressure, renal function and silent cerebrovascular lesions in Japanese: the Ohasama study Peer-reviewed

    Takuo Hirose, Kazuhito Totsune, Yukiko Nakashige, Hirohito Metoki, Masahiro Kikuya, Takayoshi Ohkubo, Azusa Hara, Michihiro Satoh, Ryusuke Inoue, Kei Asayama, Takeo Kondo, Kei Kamide, Tomohiro Katsuya, Toshio Ogihara, Shin-Ichi Izumi, Hiromi Rakugi, Kazuhiro Takahashi, Yutaka Imai

    HYPERTENSION RESEARCH 34 (12) 1327-1332 2011/12

    DOI: 10.1038/hr.2011.131  

    ISSN: 0916-9636

  82. 中年者におけるヘルスリテラシーと血圧との関連に関する検討

    渋谷 昭子, 井上 隆輔, 前田 幸宏, 梅里 良正, 根東 義明

    医療情報学連合大会論文集 31回 539-540 2011/11

    Publisher: (一社)日本医療情報学会

    ISSN: 1347-8508

  83. The relation between health literacy, hypertension knowledge, and blood pressure among middle-aged Japanese adults Peer-reviewed

    Akiko Shibuya, Ryusuke Inoue, Takayoshi Ohkubo, Yumiko Takeda, Takeo Teshima, Yutaka Imai, Yoshiaki Kondo

    BLOOD PRESSURE MONITORING 16 (5) 224-230 2011/10

    DOI: 10.1097/MBP.0b013e32834af7ba  

    ISSN: 1359-5237

  84. Aldosterone-to-renin ratio and nocturnal blood pressure decline in a general population: the Ohasama study Peer-reviewed

    Michihiro Satoh, Masahiro Kikuya, Takayoshi Ohkubo, Takefumi Mori, Hirohito Metoki, Takanao Hashimoto, Azusa Hara, Megumi T. Utsugi, Takuo Hirose, Taku Obara, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    JOURNAL OF HYPERTENSION 29 (10) 1940-1947 2011/10

    DOI: 10.1097/HJH.0b013e32834ab46a  

    ISSN: 0263-6352

    eISSN: 1473-5598

  85. Aldosterone-to-renin ratio and home blood pressure in subjects with higher and lower sodium intake: the Ohasama Study Peer-reviewed

    Michihiro Satoh, Masahiro Kikuya, Azusa Hara, Takayoshi Ohkubo, Takefumi Mori, Hirohito Metoki, Megumi T. Utsugi, Takuo Hirose, Taku Obara, Ryusuke Inoue, Kei Asayama, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    HYPERTENSION RESEARCH 34 (3) 361-366 2011/03

    DOI: 10.1038/hr.2010.236  

    ISSN: 0916-9636

  86. How many measurements are needed to provide reliable information in terms of the ambulatory arterial stiffness index? the Ohasama study Peer-reviewed

    Masahiro Kikuya, Jan A. Staessen, Takayoshi Ohkubo, Lutgarde Thijs, Kei Asayama, Michihiro Satoh, Takanao Hashimoto, Takuo Hirose, Hirohito Metoki, Taku Obara, Ryusuke Inoue, Yan Li, Eamon Dolan, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Ji-Guang Wang, Eoin O&apos;Brien, Yutaka Imai

    HYPERTENSION RESEARCH 34 (3) 314-318 2011/03

    DOI: 10.1038/hr.2010.240  

    ISSN: 0916-9636

  87. Self-monitoring of ambulatory blood pressure by the Microlife WatchBP O3--an application test. Peer-reviewed

    Nakano H, Kikuya M, Hara A, Nakashita M, Hirose T, Obara T, Metoki H, Inoue R, Asayama K, Ohkubo T, Totsune K, Imai Y

    Clinical and experimental hypertension (New York, N.Y. : 1993) 33 34-40 2011

    Publisher: 1

    DOI: 10.3109/10641963.2010.503300  

    ISSN: 1064-1963

  88. Low-Dose and Very Low-Dose Spironolactone in Combination Therapy for Essential Hypertension: Evaluation by Self-Measurement of Blood Pressure at Home Peer-reviewed

    Tomohiro Hanazawa, Taku Obara, Kei Ogasawara, Takahiro Shinki, Sakiko Katada, Ryusuke Inoue, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Nariyasu Mano, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION 33 (7) 427-436 2011

    DOI: 10.3109/10641963.2010.531844  

    ISSN: 1064-1963

    eISSN: 1525-6006

  89. Associated Factors of Home Versus Ambulatory Heart Rate Variability in the General Population: The Ohasama Study Peer-reviewed

    Kenta Gonokami, Masahiro Kikuya, Takayoshi Ohkubo, Michihiro Satoh, Takanao Hashimoto, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION 33 (6) 404-410 2011

    DOI: 10.3109/10641963.2010.549269  

    ISSN: 1064-1963

  90. Serum Magnesium, Ambulatory Blood Pressure, and Carotid Artery Alteration: The Ohasama Study Peer-reviewed

    Takanao Hashimoto, Azusa Hara, Takayoshi Ohkubo, Masahiro Kikuya, Yoriko Shintani, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Manami Nakashita, Shiho Terata, Taku Obara, Takuo Hirose, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

    AMERICAN JOURNAL OF HYPERTENSION 23 (12) 1292-1298 2010/12

    DOI: 10.1038/ajh.2010.168  

    ISSN: 0895-7061

  91. Usefulness of assessing masked and white-coat hypertension by ambulatory blood pressure monitoring for determining prevalent risk of chronic kidney disease: the Ohasama study Peer-reviewed

    Atsuhiro Kanno, Hirohito Metoki, Masahiro Kikuya, Hiroyuki Terawaki, Azusa Hara, Takanao Hashimoto, Kei Asayama, Ryusuke Inoue, Yoh Shishido, Masaaki Nakayama, Kazuhito Totsune, Takayoshi Ohkubo, Yutaka Imai

    HYPERTENSION RESEARCH 33 (11) 1192-1198 2010/11

    DOI: 10.1038/hr.2010.139  

    ISSN: 0916-9636

  92. Relationship of dysregulation of glucose metabolism with white-coat hypertension: the Ohasama study Peer-reviewed

    Miki Hosaka, Akira Mimura, Kei Asayama, Takayoshi Ohkubo, Katsuhisa Hayashi, Masahiro Kikuya, Michihiro Sato, Takanao Hashimoto, Atsuhiro Kanno, Azusa Hara, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Haruhisa Hoshi, Hiroshi Satoh, Yoshitomo Oka, Yutaka Imai

    HYPERTENSION RESEARCH 33 (9) 937-943 2010/09

    DOI: 10.1038/hr.2010.114  

    ISSN: 0916-9636

  93. Practice and awareness of physicians regarding casual-clinic blood pressure measurement in Japan Peer-reviewed

    Mitsuru Kobayashi, Taku Obara, Takayoshi Ohkubo, Hidefumi Fukunaga, Michihiro Satoh, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Masahiro Kikuya, Nariyasu Mano, Masaaki Miyakawa, Yutaka Imai

    HYPERTENSION RESEARCH 33 (9) 960-964 2010/09

    DOI: 10.1038/hr.2010.89  

    ISSN: 0916-9636

  94. Association of environmental tobacco smoke exposure with elevated home blood pressure in Japanese women: the Ohasama study Peer-reviewed

    Mami Seki, Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Azusa Hara, Hirohito Metoki, Takuo Hirose, Megumi Tsubota-Utsugi, Kei Asayama, Atsuhiro Kanno, Taku Obara, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

    JOURNAL OF HYPERTENSION 28 (9) 1814-1820 2010/09

    DOI: 10.1097/HJH.0b013e32833a3911  

    ISSN: 0263-6352

  95. Factors Associated With Day-By-Day Variability of Self-Measured Blood Pressure at Home: The Ohasama Study Peer-reviewed

    Tetsuo Kato, Masahiro Kikuya, Takayoshi Ohkubo, Michihiro Satoh, Azusa Hara, Taku Obara, Hirohito Metoki, Kei Asayama, Takuo Hirose, Ryusuke Inoue, Atsuhiro Kanno, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    AMERICAN JOURNAL OF HYPERTENSION 23 (9) 980-986 2010/09

    DOI: 10.1038/ajh.2010.94  

    ISSN: 0895-7061

  96. アンジオテンシンII受容体拮抗薬カンデサルタンの家庭血圧測定に基づく降圧速度に関する検討 Invited

    小原 拓, 安 真美子, 花澤 智大, 堅田 早紀子, 目時 弘仁, 浅山 敬, 井上 隆輔, 菊谷 昌浩, 大久保 孝義, 眞野 成康, 今井 潤

    診断と治療 98巻 (6号) 1039-1045 2010/08

    ISSN: 0370-999X

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    アンジオテンシンII受容体拮抗薬の一つであるカンデサルタンについて、家庭血圧測定に基づいて降圧速度の定量化を試みた。未治療本態性高血圧患者を対象とした。早朝・就寝前血圧は治療1週目から有意に低下した。早朝および就寝前心拍に有意な変化は認めなかった。早朝血圧において、収縮期および拡張期血圧の推移は指数関数に有意にフィッティングした。就寝前血圧においても、早朝血圧と同様、就寝前血圧の推移は指数関数に有意にフィッティングした。早朝血圧の降圧レベル別にフィッティングを行い、降圧レベルによらず、カンデサルタンによる血圧推移は指数関数に有意にフィッティングした。

  97. アンジオテンシンII受容体拮抗薬テルミサルタンの家庭血圧測定にもとづく降圧速度に関する検討 Invited

    安 真美子, 小原 拓, 花澤 智大, 小笠原 慧, 堅田 早紀子, 目時 弘仁, 浅山 敬, 井上 隆輔, 菊谷 昌浩, 大久保 孝義, 今井 潤

    血圧 17巻 (5号) 445-449 2010/07

    ISSN: 1340-4598

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    早朝平均収縮期血圧135mmHg以上/平均拡張期血圧85mmHg以上の未治療本態性高血圧患者20名(男9名、女11名、年齢60.1±7.4歳)を対象にテルミサルタン40mg 1日1回朝食後服用後の家庭血圧の推移を単純指数関数にフィッティングさせ、降圧効果安定化までの時間(stabilizing time)を求めた。早朝および就寝前心拍に有意な変化は認めなかったが、早朝および就寝前の血圧を有意に低下させ、最大降圧度は早朝収縮期血圧13.7mmHgでstabilizing timeは8.9日、早朝拡張期血圧6.8mmHgでstabilizing timeは9.6日であり、就寝前収縮期血圧は15.2mmHgでstabilizing time 8.6日、就寝前拡張期血圧7.8mmHgでstabilizing time 7.7日であった。また、家庭低血圧推移は降圧レベルによらず指数関数に有意にフィッティングし、フィッティング度合を表す回帰係数Rは0.72〜0.80でstabilizing timeは8.3〜12.6日であった。

  98. アンジオテンシンII受容体拮抗薬オルメサルタンの家庭血圧測定に基づく降圧速度に関する検討 Invited

    小原 拓, 安 真美子, 花澤 智大, 小笠原 慧, 堅田 早紀子, 目時 弘仁, 浅山 敬, 井上 隆輔, 菊谷 昌浩, 大久保 孝義, 眞野 成康, 今井 潤

    Therapeutic Research 31巻 (4号) 569-575 2010/07

    ISSN: 0289-8020

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    未治療の本態性高血圧患者26例を対象にオルメサルタン20mgを4週間投与し、その効果を家庭用血圧測定に基づく降圧度と降圧速度より検討した。その結果、早朝家庭血圧において治療4週後の降圧度は16.4/9.3 mmHgであり、降圧効果安定化までの時間は約9日であることが示唆された。

  99. Electrocardiographic abnormalities and home blood pressure in treated elderly hypertensive patients: Japan home versus office blood pressure measurement evaluation in the elderly (J-HOME-Elderly) study Peer-reviewed

    Taku Shibamiya, Taku Obara, Takayoshi Ohkubo, Takahiro Shinki, Kazuki Ishikura, Makoto Yoshida, Michihiro Satoh, Takanao Hashimoto, Azusa Hara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Masahiro Kikuya, Yutaka Imai

    HYPERTENSION RESEARCH 33 (7) 670-677 2010/07

    DOI: 10.1038/hr.2010.55  

    ISSN: 0916-9636

    eISSN: 1348-4214

  100. Practice and awareness of physicians regarding home blood pressure measurement in Japan Peer-reviewed

    Taku Obara, Takayoshi Ohkubo, Hidefumi Fukunaga, Mitsuru Kobayashi, Michihiro Satoh, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Masahiro Kikuya, Nariyasu Mano, Masaaki Miyakawa, Yutaka Imai

    HYPERTENSION RESEARCH 33 (5) 428-434 2010/05

    DOI: 10.1038/hr.2010.10  

    ISSN: 0916-9636

    eISSN: 1348-4214

  101. Stroke Risk in Treated Hypertension Based on Home Blood Pressure: the Ohasama Study Peer-reviewed

    Daisaku Yasui, Kei Asayama, Takayoshi Ohkubo, Masahiro Kikuya, Atsuhiro Kanno, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    AMERICAN JOURNAL OF HYPERTENSION 23 (5) 508-514 2010/05

    DOI: 10.1038/ajh.2010.15  

    ISSN: 0895-7061

    eISSN: 1941-7225

  102. アンジオテンシンII受容体拮抗薬ロサルタンの家庭血圧測定にもとづく降圧速度に関する検討 Invited

    安 真美子, 小原 拓, 花澤 智大, 小笠原 慧, 堅田 早紀子, 目時 弘仁, 浅山 敬, 井上 隆輔, 菊谷 昌浩, 大久保 孝義, 今井 潤

    血圧 17巻 (2号) 145-150 2010/03

    ISSN: 1340-4598

    More details Close

    未治療本態性高血圧患者23例(男12例・女11例・平均64.1歳)にロサルタン50mg/日を1日1回4週間投与し、家庭血圧測定によりその効果を検討した。早朝収縮期/拡張期血圧は治療開始前平均152.1/90.4mmHgで、降圧度は治療2週目で8.9/4.9mmHg、4週目で12.5/7.5mmHgと有意な変化を認めた。就寝前血圧は平均142.4/83.1mmHgで、降圧度は2週目13.5/7.7mmHg、4週目11.6/7.7mmHgであった。降圧速度に関してMashimaらの研究に基づくフィッティング解析を行ったところ、収縮期/拡張期血圧の推移は指数関数に有意にフィッティングした。早朝収縮期血圧の最大降圧度は11.9mmHg、stabilizing timeは22.8日、拡張期血圧はそれぞれ7.3mmHg、24.1日であった。同様に、就寝前血圧も指数関数に有意にフィッテイングし、就寝前収縮期血圧の最大降圧度は11.4mmHg、stabilizing timeは20.9日、拡張期血圧はそれぞれ6.7mmHg、21.7日であった。降圧レベル別に解析した結果も同様であった。

  103. Accumulation of common polymorphisms is associated with development of hypertension: A 12-year follow-up from the Ohasama study Peer-reviewed

    Yumiko Watanabe, Hirohito Metoki, Takayoshi Ohkubo, Tomohiro Katsuya, Yasuharu Tabara, Masahiro Kikuya, Takuo Hirose, Ken Sugimoto, Kei Asayama, Ryusuke Inoue, Azusa Hara, Taku Obara, Jun Nakura, Katsuhiko Kohara, Kazuhito Totsune, Toshio Ogihara, Hiromi Rakugi, Tetsuro Miki, Yutaka Imai

    Hypertension Research 33 (2) 129-134 2010/02

    DOI: 10.1038/hr.2009.193  

    ISSN: 0916-9636 1348-4214

  104. Parental longevity and offspring's home blood pressure: the Ohasama study Peer-reviewed

    Yumiko Watanabe, Hirohito Metoki, Takayoshi Ohkubo, Takuo Hirose, Masahiro Kikuya, Kei Asayama, Ryusuke Inoue, Azusa Hara, Taku Obara, Haruhisa Hoshi, Kazuhito Totsune, Yutaka Imai

    JOURNAL OF HYPERTENSION 28 (2) 272-277 2010/02

    DOI: 10.1097/HJH.0b013e328332fa78  

    ISSN: 0263-6352

    eISSN: 1473-5598

  105. Association of Kidney Dysfunction with Silent Lacunar Infarcts and White Matter Hyperintensity in the General Population: The Ohasama Study Peer-reviewed

    Harunori Otani, Masahiro Kikuya, Azusa Hara, Shiho Terata, Takayoshi Ohkubo, Takeo Kondo, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Hiroyuki Terawaki, Masaaki Nakayama, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Shin-Ichi Izumi, Yutaka Imai

    CEREBROVASCULAR DISEASES 30 (1) 43-50 2010

    DOI: 10.1159/000313612  

    ISSN: 1015-9770

    eISSN: 1421-9786

  106. What Determines the Later Clinical Course of Patients Who Do Not Undergo Colectomy at the First Attack? A Japanese Cohort Study on Ulcerative Colitis Peer-reviewed

    Hisashi Shiga, Sho Takagi, Ryusuke Inoue, Yoshitaka Kinouchi, Takayoshi Ohkubo, Seiichi Takahashi, Kenichi Negoro, Hiroshi Yokoyama, Seiichi Kato, Kouhei Fukushima, Nobuo Hiwatashi, Tooru Shimosegawa

    DIGESTION 81 (2) 104-112 2010

    DOI: 10.1159/000229773  

    ISSN: 0012-2823

  107. Validation of the FM-800 Ambulatory Blood Pressure Monitor According to the Association for the Advancement of Medical Instrumentation Criteria and the International Protocol Peer-reviewed

    Kaori Nakamura, Masahiro Kikuya, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Takayoshi Ohkubo, Kazuhito Totsune, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION 32 (8) 523-527 2010

    DOI: 10.3109/10641963.2010.496513  

    ISSN: 1064-1963

  108. サプリメント摂取者の人口学的特性及び生活習慣に関する研究 大迫研究 Invited

    原 梓, 大久保 孝義, 小原 拓, 坪田 恵, 宇津木, 菊谷 昌浩, 目時 弘仁, 井上 隆輔, 浅山 敬, 戸恒 和人, 星 晴久, 細川 徹, 佐藤 洋, 今井 潤

    医薬品相互作用研究 33巻 (1号) 7-13 2009/12

    ISSN: 0385-5015

    More details Close

    一般地域住民におけるサプリメント摂取者の特性及び生活習慣について検討した。岩手県花巻市大迫町における高血圧・循環器疾患に関する長期コホート研究の一環である。「生活習慣と健康に関するアンケート調査」に回答した、35歳以上の岩手県花巻市大迫町の地域住民4227例を対象とした。単変量解析でサプリメント摂取と関連が認められた因子と年齢を補正項目とし、サプリメント摂取に対するオッズ比をロジスティック回帰分析で解析した。女性において、サプリメントの摂取は、高齢、飲酒歴あり、体力不足、主観的健康度不良、学歴高校卒業以上、週1回以上の外食習慣と有意に関連した。男性において、サプリメントの摂取は、疾病既往あり、朝食の毎日摂取と有意に関連した。女性において、外向性傾向および神経症傾向がサプリメント摂取と有意に関連していた。男性において、神経症傾向とサプリメント摂取との間に有意な関連を認めた。

  109. Uncontrolled hypertension based on morning and evening home blood pressure measurements from the J-HOME study. Peer-reviewed

    Obara T, Ito K, Ohkubo T, Shibamiya T, Shinki T, Nakashita M, Hara A, Metoki H, Inoue R, Asayama K, Kikuya M, Mano N, Imai Y, J-HOME Study Group

    Hypertension research : official journal of the Japanese Society of Hypertension 32 (12) 1072-1078 2009/12

    Publisher: 12

    DOI: 10.1038/hr.2009.152  

    ISSN: 0916-9636

  110. Influence of alcohol intake on circadian blood pressure variation in Japanese men: the Ohasama study. Peer-reviewed

    Nakashita M, Ohkubo T, Hara A, Metoki H, Kikuya M, Hirose T, Tsubota-Utsugi M, Asayama K, Inoue R, Kanno A, Obara T, Hoshi H, Totsune K, Satoh H, Imai Y

    American journal of hypertension 22 1171-1176 2009/11

    Publisher: 11

    DOI: 10.1038/ajh.2009.160  

    ISSN: 0895-7061

  111. Stroke Risk of Blood Pressure Indices Determined by Home Blood Pressure Measurement The Ohasama Study Peer-reviewed

    Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Atsuhiro Kanno, Taku Obara, Takuo Hirose, Azusa Hara, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Yoshiaki Kondo, Yutaka Imai

    STROKE 40 (8) 2859-2861 2009/08

    DOI: 10.1161/STROKEAHA.108.546499  

    ISSN: 0039-2499

  112. Influence of home blood pressure measuring conditions in the evening on the morning-evening home blood pressure difference in treated hypertensive patients: the J-HOME study Peer-reviewed

    Kie Ito, Taku Obara, Takayoshi Ohkubo, Kenta Gonokami, Takahiro Shinki, Taku Shibamiya, Manami Nakashita, Mitsuru Kobayashi, Jin Funahashi, Azusa Hara, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Masahiro Kikuya, Nariyasu Mano, Yutaka Imai

    BLOOD PRESSURE MONITORING 14 (4) 160-165 2009/08

    DOI: 10.1097/MBP.0b013e32832e2a40  

    ISSN: 1359-5237

  113. The association between masked hypertension and waist circumference as an obesity-related anthropometric index for metabolic syndrome: the Ohasama study Peer-reviewed

    Kei Asayama, Atsushi Sato, Takayoshi Ohkubo, Akira Mimura, Katsuhisa Hayashi, Masahiro Kikuya, Daisaku Yasui, Atsuhiro Kanno, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    HYPERTENSION RESEARCH 32 (6) 438-443 2009/06

    DOI: 10.1038/hr.2009.37  

    ISSN: 0916-9636

  114. Repeated evening home blood pressure measurement improves prognostic significance for stroke: a 12-year follow-up of the Ohasama study Peer-reviewed

    Kei Asayama, Takayoshi Ohkubo, Azusa Hara, Takuo Hirose, Daisaku Yasui, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Masahiro Kikuya, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    BLOOD PRESSURE MONITORING 14 (3) 93-98 2009/06

    DOI: 10.1097/MBP.0b013e32832a9d91  

    ISSN: 1359-5237

  115. Detection of silent cerebrovascular lesions in individuals with &apos;masked&apos; and &apos;white-coat&apos; hypertension by home blood pressure measurement: the Ohasama study Peer-reviewed

    Azusa Hara, Takayoshi Ohkubo, Takeo Kondo, Masahiro Kikuya, Yoko Aono, Sugiko Hanawa, Kyoko Shioda, Sayaka Miyamoto, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Takuo Hirose, Kazuhito Totsune, Haruhisa Hoshi, Shin-Ichi Izumi, Hiroshi Satoh, Yutaka Imai

    JOURNAL OF HYPERTENSION 27 (5) 1049-1055 2009/05

    DOI: 10.1097/HJH.0b013e3283298522  

    ISSN: 0263-6352

  116. Decision making and physician prescribing characteristics: a pilot study of Japanese physicians. Peer-reviewed

    Shibuya Akiko, Nakayama Masaharu, Inoue Ryusuke, Imai Yutaka, Kondo Yoshiaki

    AMIA Annu Symp Proc 2009 604-608 2009/04

  117. 家庭血圧・随時血圧とアディポサイトカインとの関連 大迫研究 Peer-reviewed

    林克剛, 浅山敬, 大久保孝義, 菊谷昌浩, 三村亨, 保坂美樹, 原梓, 小原拓, 目時弘仁, 井上隆輔, 星晴久, 佐藤洋, 及川眞一, 今井潤

    日本循環器病予防学会誌 44 (2) 98-98 2009/04

  118. 飲酒習慣と血圧日内変動の横断的検討 大迫研究 Peer-reviewed

    中下愛実, 大久保孝義, 原梓, 菊谷昌浩, 目時弘仁, 宇津木恵, 浅山敬, 井上隆輔, 菅野厚博, 戸恒和人, 星晴久, 佐藤洋, 今井潤

    日本循環器病予防学会誌 44 (2) 97-97 2009/04

  119. Masked Hypertension Determined by Self-Measured Blood Pressure at Home and Chronic Kidney Disease in the Japanese General Population: The Ohasama Study Peer-reviewed

    Hiroyuki Terawaki, Hirohito Metoki, Masaaki Nakayama, Takayoshi Ohkubo, Masahiro Kikuya, Kei Asayama, Ryusuke Inoue, Haruhisa Hoshi, Sadayoshi Ito, Yutaka Imai

    HYPERTENSION RESEARCH 31 (12) 2129-2135 2008/12

    DOI: 10.1291/hypres.31.2129  

    ISSN: 0916-9636

  120. Day-by-Day Variability of Blood Pressure and Heart Rate at Home as a Novel Predictor of Prognosis The Ohasama Study Peer-reviewed

    Masahiro Kikuya, Takayoshi Ohkubo, Hirohito Metoki, Kei Asayama, Azusa Hara, Taku Obara, Ryusuke Inoue, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

    HYPERTENSION 52 (6) 1045-1050 2008/12

    DOI: 10.1161/HYPERTENSIONAHA.107.104620  

    ISSN: 0194-911X

  121. 大迫研究から 日本の高血圧治療ガイドラインに基づいた脳卒中リスク分類 Peer-reviewed

    浅山敬, 大久保孝義, 菊谷昌浩, 廣瀬卓男, 原梓, 菅野厚博, 安井大策, 小原拓, 目時弘仁, 井上隆輔, 橋本潤一郎, 戸恒和人, 星晴久, 佐藤洋, 今井潤

    血圧 15 (10) 902-903 2008/10

    Publisher:

    ISSN: 1340-4598

  122. Predictive value of ambulatory heart rate in the Japanese general population: the Ohasama study Peer-reviewed

    Atsushi Hozawa, Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Azusa Hara, Takuo Hirose, Atsuhiro Kanno, Taku Obara, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

    JOURNAL OF HYPERTENSION 26 (8) 1571-1576 2008/08

    DOI: 10.1097/HJH.0b013e3283041172  

    ISSN: 0263-6352

  123. Proposal of a risk-stratification system for the Japanese population based on blood pressure levels: the Ohasama study. Peer-reviewed

    Asayama K, Ohkubo T, Sato A, Hara A, Obara T, Yasui D, Metoki H, Inoue R, Kikuya M, Hashimoto J, Hoshi H, Satoh H, Imai Y

    Hypertension research : official journal of the Japanese Society of Hypertension 31 (7) 1315-1322 2008/07

    Publisher: 7

    DOI: 10.1291/hypres.31.1315  

    ISSN: 0916-9636

  124. Difference between home and office blood pressures among treated hypertensive patients from the Japan Home versus Office Blood Pressure Measurement Evaluation (J-HOME) study Peer-reviewed

    Tsuyoshi Horikawa, Taku Obara, Takayoshi Ohkubo, Hirohito Metoki, Ryusuke Inoue, Masahiro Kikuya, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

    HYPERTENSION RESEARCH 31 (6) 1115-1123 2008/06

    DOI: 10.1291/hypres.31.1115  

    ISSN: 0916-9636

  125. Optimal cutoff point of waist circumference and use of home blood pressure as a definition of metabolic syndrome: The Ohasama study Peer-reviewed

    Atsushi Sato, Kei Asayama, Takayoshi Ohkubo, Masahiro Kikuya, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Azusa Hara, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yoshitomo Oka, Yutaka Imai

    AMERICAN JOURNAL OF HYPERTENSION 21 (5) 514-520 2008/05

    DOI: 10.1038/ajh.2007.88  

    ISSN: 0895-7061

  126. Automated measurement of cardiothoracic ratio using an R package. Peer-reviewed

    Nakayama Masaharu, Shibuya Akiko, Inoue Ryusuke, Kondo Yoshiaki

    AMIA Annu Symp Proc 1064-1064 2008/04

  127. The Medical Cells: For the spread of Clinical knowledge management. Peer-reviewed

    Shibuya Akiko, Nakayama Masaharu, Inoue Ryusuke, Endo Akira, Imai Yutaka, Kondo Yoshiaki

    AMIA Annu Symp Proc 1130-1130 2008/04

  128. Large Scale Intervention Study to Hypertension with Information Technology: Hypertension Objective treatment based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) Study. Peer-reviewed

    Inoue Ryusuke, Nakayama Masaharu, Shibuya Akiko, Ohkubo Takayoshi, Asayama Kei, Metoki Hirohito, Tamura Tomoko, Kondo Yoshiaki, Imai Yutaka

    AMIA Annu Symp Proc 986-986 2008/04

  129. Association of micro albuminuria with brachial-ankle pulse wave velocity: The ohasama study Peer-reviewed

    Tomofumi Ishikawa, Junichiro Hashimoto, Rieko H. Morito, Tomohiro Hanazawa, Tomoyuki Aikawa, Azusa Hara, Yoriko Shintani, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    AMERICAN JOURNAL OF HYPERTENSION 21 (4) 413-418 2008/04

    DOI: 10.1038/ajh.2007.77  

    ISSN: 0895-7061

  130. Cost-effectiveness of the introduction of home blood pressure measurement in patients with office hypertension Peer-reviewed

    Hidefumi Fukunaga, Takayoshi Ohkubo, Makoto Kobayashi, Yuichiro Tamaki, Masahiro Kikuya, Taku Obara, Miwa Nakagawa, Azusa Hara, Kei Asayama, Hirohito Metoki, Ryusuke Inoue, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

    JOURNAL OF HYPERTENSION 26 (4) 685-690 2008/04

    DOI: 10.1097/HJH.0b013e3282f42285  

    ISSN: 0263-6352

    eISSN: 1473-5598

  131. 血清マグネシウム濃度と頸動脈硬化指標の横断的検討 大迫研究 Peer-reviewed

    橋本貴尚, 新谷依子, 原梓, 菊谷昌浩, 大久保孝義, 大谷陽範, 田中一翔, 浅山敬, 井上隆輔, 目時弘仁, 小原拓, 森戸里衣子, 橋本潤一郎, 戸恒和人, 星晴久, 佐藤洋, 今井潤

    日本循環器病予防学会誌 43 (1) 77-86 2008/04

    Publisher:

    ISSN: 1346-6267

  132. 家庭血圧に基づく仮面高血圧・白衣高血圧と、ウエスト周囲径ならびにBMIに関する横断的検討 大迫研究 Peer-reviewed

    佐藤敦, 浅山敬, 大久保孝義, 菊谷昌浩, 三村享, 原梓, 小原拓, 目時弘仁, 井上隆輔, 星晴久, 佐藤洋, 坂本尚夫, 今井潤

    日本循環器病予防学会誌 43 (1) 39-39 2008/04

  133. Home blood pressure measurements associated with better blood pressure control: the J-HOME study Peer-reviewed

    T. Obara, T. Ohkubo, K. Asayama, H. Metoki, R. Inoue, M. Kikuya, T. Kato, K. Tanaka, A. Hara, J. Hashimoto, K. Totsune, Y. Imai

    JOURNAL OF HUMAN HYPERTENSION 22 (3) 197-204 2008/03

    DOI: 10.1038/sj.jhh.1002320  

    ISSN: 0950-9240

  134. Prevalence of masked hypertension in subjects treated with antihypertensive drugs as assessed by morning versus evening home blood pressure measurements: The J-HOME study Peer-reviewed

    Taku Obara, Takayoshi Ohkubo, Kei Asayama, Masahiro Kikuya, Hirohito Metoki, Ryusuke Inoue, Rie Komai, Kayo Murai, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION 30 (3-4) 277-287 2008

    DOI: 10.1080/10641960802071018  

    ISSN: 1064-1963

  135. Time-dependent effects of imidapril administration in patients with morning hypertension measured as home blood pressure Peer-reviewed

    Takako Shibasaki, Taku Obara, Takayoshi Ohkubo, Azusa Hara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Masahiro Kikuya, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION 30 (3-4) 243-254 2008

    DOI: 10.1080/10641960802069806  

    ISSN: 1064-1963

  136. Incorporating self-blood pressure measurements at home in the guideline from the Ohasama study Peer-reviewed

    Takayoshi Ohkubo, Masahiro Kikuya, Kei Asayama, Hirohito Metoki, Azusa Hara, Ryusuke Inoue, Taku Obara, Takuo Hirose, Rieko Hatanaka, Atsushi Hozawa, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

    BLOOD PRESSURE MONITORING 12 (6) 407-409 2007/12

    DOI: 10.1097/MBP.0b013e328244e8a7  

    ISSN: 1359-5237

  137. PubMedからのコピー&ペーストによる複数一括取り込み可能な論文業績管理システムの導入効果 Peer-reviewed

    大佐賀敦, 佐藤大, 中村直毅, 井上隆輔, 國井重男, 近藤克幸, 根東義明

    第27回医療情報学連合大会論文集 1271-1272 2007/11/23

  138. Factors affecting heart rate as measured at home among treated hypertensive patients: The Japan Home versus Office blood pressure Measurement Evaluation (J-HOME) study Peer-reviewed

    Rie Komai, Taku Obara, Takayoshi Ohkubo, Tetsuo Kato, Masahiro Kikuya, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Azusa Hara, Koji Tanaka, Kenta Gonokami, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

    HYPERTENSION RESEARCH 30 (11) 1051-1057 2007/11

    DOI: 10.1291/hypres.30.1051  

    ISSN: 0916-9636

  139. Stroke risk in Systolic and combined Systolic and Diastolic hypertension determined using ambulatory blood pressure Peer-reviewed

    Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Taku Obara, Takuo Hirose, Azusa Hara, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yoshiaki Kondo, Yutaka Imai

    AMERICAN JOURNAL OF HYPERTENSION 20 (10) 1125-1131 2007/10

    DOI: 10.1016/j.amjhyper.2007.04.017  

    ISSN: 0895-7061

  140. Control of home heart rate and home blood pressure levels in treated patients with hypertension: the J-HOME study Peer-reviewed

    Taku Obara, Takayoshi Ohkubo, Rie Komai, Kei Asayama, Masahiro Kikuya, Hirohito Metoki, Ryusuke Inoue, Kayo Murai, Koji Tanaka, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

    BLOOD PRESSURE MONITORING 12 (5) 289-295 2007/10

    DOI: 10.1097/MBP.0b013e3282c9ad42  

    ISSN: 1359-5237

  141. 早朝高血圧患者におけるオルメサルタンとアムロジピンの薬効比較 Peer-reviewed

    佐藤茜, 小原拓, 大久保孝義, 井上奈緒, 目時弘仁, 井上隆輔, 浅山敬, 菊谷昌浩, 橋本潤一郎, 戸恒和人, 今井潤

    臨床高血圧 13 (3) 199-207 2007/09

    Publisher:

    ISSN: 1342-2154

  142. Reproducibility of nocturnal blood pressure assessed by self-measurement of blood pressure at home Peer-reviewed

    Keiko Hosohata, Masahiro Kikuya, Takayoshi Ohkubo, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Taku Obara, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    HYPERTENSION RESEARCH 30 (8) 707-712 2007/08

    DOI: 10.1291/hypres.30.707  

    ISSN: 0916-9636

  143. Ambulatory blood pressure, blood pressure variability and the prevalence of carotid artery alteration: the Ohasama study Peer-reviewed

    Yoriko Shintani, Masahiro Kikuya, Azusa Hara, Takayoshi Ohkubo, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Taku Obara, Yoko Aono, Takanao Hashimoto, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    JOURNAL OF HYPERTENSION 25 (8) 1704-1710 2007/08

    DOI: 10.1097/HJH.0b013e328172dc2e  

    ISSN: 0263-6352

  144. Kidney dysfunction as a risk factor for first symptomatic stroke events in a general Japanese population - the Ohasama study Peer-reviewed

    Masaaki Nakayama, Hirohito Metoki, Hiroyuki Terawaki, Takayoshi Ohkubo, Masahiro Kikuya, Toshinobu Sato, Keisuke Nakayama, Kei Asayama, Ryusuke Inoue, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Sadayoshi Ito, Yutaka Imai

    NEPHROLOGY DIALYSIS TRANSPLANTATION 22 (7) 1910-1915 2007/07

    DOI: 10.1093/ndt/gfm051  

    ISSN: 0931-0509

  145. An XML-based integration method for different types of patient data in cardiology. Invited Peer-reviewed

    Nakayama Masaharu, Shibuya Akiko, Inoue Ryusuke, Ohsaga Atsushi, Kondo Yoshiaki

    AMIA Annu Symp Proc 1057-1057 2007/04

  146. A new approach to medical and clinical knowledge management by using the Medical Cells strategy. Peer-reviewed

    Shibuya Akiko, Inoue Ryusuke, Ohsaga Atsushi, Nakayama Masaharu, Endo Akira, Kondo Yoshiaki

    AMIA Annu Symp Proc 1113-1113 2007/04

  147. Ambulatory arterial stiffness index and 24-hour ambulatory pulse pressure as predictors of mortality in Ohasama, Japan Peer-reviewed

    Masahiro Kikuya, Jan A. Staessen, Takayoshi Ohkubo, Lutgarde Thijs, Hirohito Metoki, Kei Asayama, Taku Obara, Ryusuke Inoue, Yan Li, Eamon Dolan, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Ji-Guang Wang, Eoin O'Brien, Yutaka Imai

    STROKE 38 (4) 1161-1166 2007/04

    DOI: 10.1161/01.STR.0000259604.67283.69  

    ISSN: 0039-2499

  148. Plasma fibrinogen, ambulatory blood pressure, and silent cerebrovascular lesions: the Ohasama study. International-journal Peer-reviewed

    Aono Yoko, Ohkubo Takayoshi, Kikuya Masahiro, Hara Azusa, Kondo Takeo, Obara Taku, Metoki Hirohito, Inoue Ryusuke, Asayama Kei, Shintani Yoriko, Hashimoto Junichiro, Totsune Kazuhito, Hoshi Haruhisa, Satoh Hiroshi, Izumi Shin-ichi, Imai Yutaka

    Arterioscler Thromb Vasc Biol 27 (4) 963-968 2007/04

    DOI: 10.1161/01.ATV.0000258947.17570.38  

    eISSN: 1524-4636

    More details Close

    OBJECTIVE: Twenty-four-hour ambulatory blood pressure (24-hour ABP) values are considered a powerful predictor of stroke. Silent cerebrovascular lesions are associated with an increased risk of stroke. Because fibrinogen is a major determinant of plasma viscosity, an elevated fibrinogen level might also be associated with stroke risk. We evaluated the association of 24-hour ABP and plasma fibrinogen levels with the risk of silent cerebrovascular lesions (white matter hyperintensity and lacunar infarct) detected by MRI. METHODS AND RESULTS: The study cohort comprised 958 individuals from the general population of Ohasama, a rural Japanese community. Multiple logistic regression analysis adjusted for age, sex, smoking and drinking status, use of antihypertensive medication, body mass index, 24-hour ABP, and a history of hypercholesterolemia, diabetes mellitus, and atrial fibrillation demonstrated that each 1-SD increase in fibrinogen level was associated with a significantly increased risk of silent cerebrovascular lesions (odds ratio, 1.26; P=0.001). The 24-hour ABP was also significantly and independently associated with the risk of silent cerebrovascular lesions. Even when 24-hour ABP values were within normal range (<135/80 mm Hg), elevated fibrinogen levels were associated with an increased risk of silent cerebrovascular lesions. Fibrinogen and 24-hour BP had additive effects on silent cerebrovascular lesions. CONCLUSION: The 24-hour ABP and plasma fibrinogen levels were closely and independently associated with the risk of silent cerebrovascular lesions including white matter hyperintensity and lacunar infarct.

  149. Detection of carotid atherosclerosis in individuals with masked hypertension and white-coat hypertension by self-measured blood pressure at home: The Ohasama Study Peer-reviewed

    Azusa Hara, Takayoshi Ohkubo, Masahiro Kikuya, Yoriko Shintani, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Takanao Hashimoto, Toshiya Harasawa, Yoko Aono, Harunori Otani, Kazushi Tanaka, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

    JOURNAL OF HYPERTENSION 25 (2) 321-327 2007/02

    DOI: 10.1097/HJH.0b013e3280115bbf  

    ISSN: 0263-6352

  150. 家庭血圧にもとづく選択的AT1受容体拮抗薬オルメサルタンの臨床的評価 Peer-reviewed

    井上奈緒, 小原拓, 大久保孝義, 佐藤茜, 中川美和, 橋本貴尚, 皆川加奈, 渡邉悠美子, 目時弘仁, 井上隆輔, 浅山敬, 菊谷昌浩, 橋本潤一郎, 戸恒和人, 今井潤

    血圧 14 (2) 205-212 2007/02

    Publisher:

    ISSN: 1340-4598

  151. Current usage of diuretics among hypertensive patients in Japan: The Japan home versus office blood pressure measurement evaluation (J-HOME) study Peer-reviewed

    Kayo Murai, Taku Obara, Takayoshi Ohkubo, Hirohito Metoki, Takuya Oikawa, Ryusuke Inoue, Rie Komai, Tsuyoshi Horikawa, Kei Asayama, Masahiro Kikuya, Kazuhito Totsune, Junichiro Hashimoto, Yutaka Imai

    HYPERTENSION RESEARCH 29 (11) 857-863 2006/11

    DOI: 10.1291/hypres.29.857  

    ISSN: 0916-9636

  152. Predicting stroke using 4 ambulatory blood pressure monitoring-derived blood pressure indices - The ohasama study Peer-reviewed

    Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Taku Obara, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yoshiaki Kondo, Yutaka Imai

    HYPERTENSION 48 (5) 877-882 2006/11

    DOI: 10.1161/01.HYP.0000242285.83728.ee  

    ISSN: 0194-911X

  153. PubMedからのコピー&ペーストによる複数一括取り込み可能な論文業績管理システム

    大佐賀 敦, 佐藤 大, 井上 隆輔, 國井 重男, 根東 義明

    医療情報学連合大会論文集 26回 696-697 2006/10

    Publisher: (一社)日本医療情報学会

    ISSN: 1347-8508

  154. Prediction of stroke by home "morning" versus "evening" blood pressure values - The Ohasama study Peer-reviewed

    Kei Asayama, Takayoshi Ohkubo, Masahiro Kikuya, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Azusa Hara, Takuo Hirose, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

    HYPERTENSION 48 (4) 737-743 2006/10

    DOI: 10.1161/01.HYP.0000240332.01877.11  

    ISSN: 0194-911X

  155. The economic impact of the introduction of home blood pressure measurement for the diagnosis and treatment of hypertension Peer-reviewed

    Jin Funahashi, Takayoshi Ohkubo, Hidefumi Fukunaga, Masahiro Kikuya, Noriko Takada, Kei Asayama, Hirohito Metoki, Taku Obara, Ryusuke Inoue, Junichiro Hashimoto, Kazuhito Totsune, Makoto Kobayashi, Yutaka Imai

    BLOOD PRESSURE MONITORING 11 (5) 257-267 2006/10

    DOI: 10.1097/01.mbp.0000217996.19839.70  

    ISSN: 1359-5237

  156. 家庭血圧に基づいた高血圧管理ガイドラインの有用性 大迫研究 Peer-reviewed

    浅山敬, 大久保孝義, 小原拓, 菊谷昌浩, 目時弘仁, 井上隆輔, 星晴久, 橋本潤一郎, 戸恒和人, 佐藤洋, 今井潤

    血圧 13 (10) 1130-1131 2006/10

    Publisher:

    ISSN: 1340-4598

  157. 家庭血圧測定経験の有無と降圧治療 J-HOME研究より Peer-reviewed

    小原拓, 大久保孝義, 浅山敬, 目時弘仁, 井上隆輔, 菊谷昌浩, 橋本潤一郎, 戸恒和人, 今井潤

    血圧 13 (10) 1128-1129 2006/10

    Publisher:

    ISSN: 1340-4598

  158. The current status of home and office blood pressure control among hypertensive patients with diabetes mellitus: The Japan Home Versus Office Blood Pressure Measurement Evaluation (J-HOME) study Peer-reviewed

    Taku Obara, Takayoshi Ohkubo, Masahiro Kikuya, Kei Asayama, Hirohito Metoki, Ryusuke Inoue, Takuya Oikawa, Kayo Murai, Rie Komai, Tsuyoshi Horikawa, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

    DIABETES RESEARCH AND CLINICAL PRACTICE 73 (3) 276-283 2006/09

    DOI: 10.1016/j.diabres.2006.01.015  

    ISSN: 0168-8227

  159. Prevalence of masked uncontrolled and treated white-coat hypertension defined according to the average of morning and evening home blood pressure value: from the Japan Home versus Office Measurement Evaluation Study Peer-reviewed

    T Obara, T Ohkubo, M Kikuya, K Asayama, H Metoki, R Inoue, T Oikawa, R Komai, K Murai, T Horikawa, J Hashimoto, K Totsune, Y Imai

    BLOOD PRESSURE MONITORING 10 (6) 311-316 2005/12

    DOI: 10.1097/00126097-200512000-00005  

    ISSN: 1359-5237

  160. 血漿フィブリノーゲン値と無症候性脳血管障害との関連大迫研究 Peer-reviewed

    青野蓉子, 菊谷昌浩, 原梓, 大久保孝義, 近藤健男, 浅山敬, 井上隆輔, 目時弘仁, 小原拓, 新谷依子, 橋本潤一郎, 戸恒和人, 星晴久, 佐藤洋, 出江伸一, 今井潤

    日本循環器病予防学会誌 40 (3) 181-189 2005/10

    Publisher:

    DOI: 10.11381/jjcdp2001.40.181  

    ISSN: 1346-6267

  161. 家庭血圧による血圧日間変動の脳卒中予測能 Peer-reviewed

    菊谷昌浩, 大久保孝義, 浅山敬, 目時弘仁, 小原拓, 井上隆輔, 星晴久, 橋本潤一郎, 戸恒和人, 佐藤洋, 今井潤

    血圧 12 (9) 990-991 2005/09

    Publisher:

    ISSN: 1340-4598

  162. 小児科医メーリングリストの専門医間コミュニケーションツールとしての有用性 Peer-reviewed

    井上隆輔, 古関義人, 大佐賀敦, 根東義明

    日本小児科学会雑誌 109 (5) 686-690 2005/05

    Publisher:

    ISSN: 0001-6543

Show all ︎Show first 5

Misc. 140

  1. 慢性腎臓病と高血圧の脳卒中発症生涯リスク:大迫研究

    中山晋吾, 佐藤倫広, 目時弘仁, 村上任尚, 浅山敬, 原梓, 廣瀬卓男, 菅野厚博, 井上隆輔, 坪田恵, 菊谷昌浩, 森建文, 寳澤篤, 今井潤, 大久保孝義

    日本腎臓学会誌(Web) 62 (4) 2020

    ISSN: 1884-0728

  2. 本態性高血圧患者における治療前および降圧治療中の家庭血圧指標の予後予測能 HOMED-BP研究

    渡部 大介, 浅山 敬, 花澤 智大, 保坂 実樹, 佐藤 倫広, 安井 大策, 小原 拓, 井上 隆輔, 目時 弘仁, 菊谷 昌浩, 今井 潤, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集 42回 223-223 2019/10

    Publisher: (NPO)日本高血圧学会

  3. NT-proBNPと慢性腎臓病との関連性 大迫研究

    中山 晋吾, 佐藤 倫宏, 目時 弘仁, 村上 任尚, 浅山 敬, 原 梓, 廣瀬 卓男, 井上 隆輔, 坪田 恵, 宇津木, 菊谷 昌浩, 森 建文, 寳澤 篤, 野出 孝一, 今井 潤, 大久保 孝義

    日本腎臓学会誌 61 (3) 289-289 2019/05

    Publisher: (一社)日本腎臓学会

    ISSN: 0385-2385

    eISSN: 1884-0728

  4. NT-proBNPと慢性腎臓病との関連性 大迫研究

    中山 晋吾, 佐藤 倫宏, 目時 弘仁, 村上 任尚, 浅山 敬, 原 梓, 廣瀬 卓男, 井上 隆輔, 坪田 恵, 宇津木, 菊谷 昌浩, 森 建文, 寳澤 篤, 野出 孝一, 今井 潤, 大久保 孝義

    日本腎臓学会誌 61 (3) 289-289 2019/05

    Publisher: (一社)日本腎臓学会

    ISSN: 0385-2385

  5. 米国高血圧新基準と一般地域住民における白衣・仮面高血圧の分布 大迫研究

    佐藤 倫広, 村上 任尚, 浅山 敬, 菊谷 昌浩, 坪田 恵, 原 梓, 松田 彩子, 井上 隆輔, 野村 恭子, 目時 弘仁, 今井 潤, 大久保 孝義

    東北公衆衛生学会誌 (67) 25-25 2018/07

    Publisher: 東北公衆衛生学会

    ISSN: 0915-549X

  6. 米国高血圧新基準と一般地域住民における白衣・仮面高血圧の分布 大迫研究

    佐藤 倫広, 村上 任尚, 浅山 敬, 菊谷 昌浩, 坪田 恵, 原 梓, 松田 彩子, 井上 隆輔, 野村 恭子, 目時 弘仁, 今井 潤, 大久保 孝義

    東北公衆衛生学会誌 (67) 25-25 2018/07

    Publisher: 東北公衆衛生学会

    ISSN: 0915-549X

  7. 睡眠時間と潜在性脳血管病変の関連 大迫研究

    朝倉 佳桜里, 原 梓, 浅山 敬, 佐藤 倫広, 藤田 彩未, 菊谷 昌浩, 井上 隆輔, 野村 恭子, 目時 弘仁, 今井 潤, 大久保 孝義

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集 7回 193-193 2018/05

    Publisher: (NPO)日本高血圧学会

  8. 自由行動下血圧により定義した白衣高血圧・仮面高血圧の頸動脈病変 大迫研究

    藤田 彩未, 原 梓, 浅山 敬, 佐藤 倫広, 朝倉 佳桜里, 菊谷 昌浩, 井上 隆輔, 野村 恭子, 目時 弘仁, 今井 潤, 大久保 孝義

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集 7回 206-206 2018/05

    Publisher: (NPO)日本高血圧学会

  9. 睡眠時間と潜在性脳血管病変の関連 大迫研究

    朝倉 佳桜里, 原 梓, 浅山 敬, 佐藤 倫広, 藤田 彩未, 菊谷 昌浩, 井上 隆輔, 野村 恭子, 目時 弘仁, 今井 潤, 大久保 孝義

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集 7回 193-193 2018/05

    Publisher: (NPO)日本高血圧学会

  10. 自由行動下血圧により定義した白衣高血圧・仮面高血圧の頸動脈病変 大迫研究

    藤田 彩未, 原 梓, 浅山 敬, 佐藤 倫広, 朝倉 佳桜里, 菊谷 昌浩, 井上 隆輔, 野村 恭子, 目時 弘仁, 今井 潤, 大久保 孝義

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集 7回 206-206 2018/05

    Publisher: (NPO)日本高血圧学会

  11. The fine-scale genetic structure and evolution of the Japanese population

    Fumihiko Takeuchi, Tomohiro Katsuya, Ryosuke Kimura, Toru Nabika, Minoru Isomura, Takayoshi Ohkubo, Yasuharu Tabara, Ken Yamamoto, Mitsuhiro Yokota, Xuanyao Liu, Xuanyao Liu, Woei Yuh Saw, Woei Yuh Saw, Dolikun Mamatyusupu, Wenjun Yang, Shuhua Xu, Shuhua Xu, Shuhua Xu, Yik Ying Teo, Yik Ying Teo, Yik Ying Teo, Yik Ying Teo, Yik Ying Teo, Yik Ying Teo, Norihiro Kato, Koichi Akiyama, Hiroyuki Asano, Kei Asayama, Toshikazu Haga, Azusa Hara, Takuo Hirose, Miki Hosaka, Sahoko Ichihara, Yutaka Imai, Ryusuke Inoue, Aya Ishi-guro, Minoru Isomura, Masato Isono, Kei Kamide, Norihiro Kato, Tomohiro Katsuya, Masahiro Kikuya, Katsuhiko Kohara, Tatsuaki Matsubara, Ayako Matsuda, Hirohito Metoki, Tetsuro Miki, Tetsuro Miki, Keiko Murakami, Toru Nabika, Masahiro Nakatochi, Toshio Ogihara, Keizo Ohnaka, Takayoshi Ohkubo, Hiromi Rakugi, Michihiro Satoh, Kuni hiro Shiwaku, Ken Sugimoto, Yasuharu Tabara, Yoichi Takami, Ryoichi Takayanagi, Fumihiko Takeuchi, Megumi Tsubota-Utsugi, Ken Yamamoto, Koichi Yamamoto, Masayuki Yamasaki, Daisaku Yasui, Mitsuhiro Yokota

    PLoS ONE 12 2017/11/01

    DOI: 10.1371/journal.pone.0185487  

  12. 家庭血圧および家庭脈拍とそれらの日間変動の加齢に伴う推移―大迫研究―

    佐藤倫広, 浅山敬, 浅山敬, 菊谷昌浩, 井上隆輔, 小原拓, 小原拓, 村上慶子, 村上任尚, 原梓, 川崎良, 野村恭子, 目時弘仁, 今井潤, 大久保孝義

    日本高血圧学会総会プログラム・抄録集 40th 409-409 2017/10/20

    Publisher: (NPO)日本高血圧学会

  13. 降圧治療中患者におけるHome Arterial Stiffness Index(HASI)の臨床的有用性の評価

    小原拓, 菊谷昌浩, 佐藤倫広, 井上隆輔, 浅山敬, 目時弘仁, 目時弘仁, 今井潤, 大久保孝義

    日本高血圧学会総会プログラム・抄録集 40th 446-446 2017/10/20

    Publisher: (NPO)日本高血圧学会

  14. 降圧治療中患者におけるHome Arterial Stiffness Index(HASI)の臨床的有用性の評価

    小原 拓, 菊谷 昌浩, 佐藤 倫広, 井上 隆輔, 浅山 敬, 目時 弘仁, 今井 潤, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集 40回 446-446 2017/10

    Publisher: (NPO)日本高血圧学会

  15. 一般地域住民における家庭血圧に基づく高血圧の分布 大迫研究

    佐藤 倫広, 村上 任尚, 浅山 敬, 菊谷 昌浩, 井上 隆輔, 坪田 恵, 小原 拓, 村上 慶子, 松田 彩子, 原 梓, 野村 恭子, 目時 弘仁, 今井 潤, 大久保 孝義

    東北公衆衛生学会誌 (66) 40-40 2017/07

    Publisher: 東北公衆衛生学会

    ISSN: 0915-549X

  16. 高たんぱく食生活と耐糖能異常発症リスクとの関連 岩手県大迫町における追跡から

    今井 絵理, 坪田 恵, 宇津木, 伊藤 美沙, 佐藤 倫広, 菊谷 昌浩, 浅山 敬, 井上 隆輔, 村上 慶子, 松田 彩子, 村上 任尚, 野村 恭子, 目時 弘仁, 今井 潤, 大久保 孝義

    日本栄養・食糧学会大会講演要旨集 71回 352-352 2017/04

    Publisher: (公社)日本栄養・食糧学会

  17. eXChartを用いた診療情報の利用

    佐藤佳奈子, 末永洋子, 井上隆輔, 中村直毅, 中山雅晴

    医療情報学連合大会論文集(CD-ROM) 37th 2017

    ISSN: 2433-698X

  18. HIGH -PROTEIN DIETARY PATTERN INCREASED A RISK OF IMPAIRED GLUCOSE TOLERANCE: THE OHASAMA STUDY Peer-reviewed

    Imai Eri, Tsubota-Utsugi Megumi, Satoh Michihiro, Kikuya Masahiro, Asayama Kei, Inoue Ryusuke, Murakami Takahisa, Metoki Hirohito, Imai Yutaka, Ohkubo Takayoshi

    ANNALS OF NUTRITION AND METABOLISM 71 934 2017

    ISSN: 0250-6807

  19. 家庭血圧値は身体機能レベルが低下した高齢者においても脳卒中発症を予測する:大迫研究

    村上慶子, 浅山敬, 浅山敬, 佐藤倫広, 井上隆輔, 坪田恵, 松田彩子, 野村恭子, 村上任尚, 菊谷昌浩, 目時弘仁, 今井潤, 大久保孝義

    日本高血圧学会総会プログラム・抄録集 39th 318-318 2016/09/30

    Publisher: (NPO)日本高血圧学会

  20. 一般地域住民における異なる時間定義に基づく夜間降圧度と脳心血管長期予後との関連―大迫研究―

    佐藤倫広, 浅山敬, 浅山敬, 菊谷昌浩, 井上隆輔, 坪田恵, 小原拓, 小原拓, 村上慶子, 松田彩子, 村上任尚, 野村恭子, 目時弘仁, 今井潤, 大久保孝義

    日本高血圧学会総会プログラム・抄録集 39th 319-319 2016/09/30

    Publisher: (NPO)日本高血圧学会

  21. 家庭血圧の季節変動と脳心血管イベントとの関連:HOMED‐BP研究

    花澤智大, 花澤智大, 浅山敬, 浅山敬, 渡部大介, 渡部大介, 田辺杏由美, 佐藤倫広, 井上隆輔, 小原拓, 小原拓, 菊谷昌浩, 野村恭子, 目時弘仁, 大久保孝義, 今井潤

    日本高血圧学会総会プログラム・抄録集 39th 387-387 2016/09/30

    Publisher: (NPO)日本高血圧学会

  22. 家庭血圧値は身体機能レベルが低下した高齢者においても脳卒中発症を予測する 大迫研究

    村上 慶子, 浅山 敬, 佐藤 倫広, 井上 隆輔, 坪田 恵, 松田 彩子, 野村 恭子, 村上 任尚, 菊谷 昌浩, 目時 弘仁, 今井 潤, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集 39回 318-318 2016/09

    Publisher: (NPO)日本高血圧学会

  23. 一般地域住民における異なる時間定義に基づく夜間降圧度と脳心血管長期予後との関連 大迫研究

    佐藤 倫広, 浅山 敬, 菊谷 昌浩, 井上 隆輔, 坪田 恵, 小原 拓, 村上 慶子, 松田 彩子, 村上 任尚, 野村 恭子, 目時 弘仁, 今井 潤, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集 39回 319-319 2016/09

    Publisher: (NPO)日本高血圧学会

  24. 家庭血圧の季節変動と脳心血管イベントとの関連 HOMED-BP研究

    花澤 智大, 浅山 敬, 渡部 大介, 田辺 杏由美, 佐藤 倫広, 井上 隆輔, 小原 拓, 菊谷 昌浩, 野村 恭子, 目時 弘仁, 大久保 孝義, 今井 潤

    日本高血圧学会総会プログラム・抄録集 39回 387-387 2016/09

    Publisher: (NPO)日本高血圧学会

  25. 本態性高血圧患者における未治療時および降圧治療中の家庭血圧指標(収縮期、拡張期、平均、脈圧)の脳心血管イベント予測能 HOMED-BP研究

    渡部 大介, 浅山 敬, 花澤 智大, 安井 大策, 井上 隆輔, 保坂 実樹, 佐藤 倫広, 小原 拓, 目時 弘仁, 菊谷 昌浩, 今井 潤, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集 38回 396-396 2015/10

    Publisher: (NPO)日本高血圧学会

  26. 新生児血圧に影響する要因の検討 BOSHI-新生児研究

    井上 隆輔, 目時 弘仁, 大久保 孝義, 小原 拓, 菊谷 昌浩, 佐藤 倫広, 保坂 実樹, 多田 秀子, 八木橋 香津代, 田中 耕平, 星 和彦, 森 滋, 鈴木 雅洲, 今井 潤

    日本高血圧学会総会プログラム・抄録集 38回 406-406 2015/10

    Publisher: (NPO)日本高血圧学会

  27. Differential effects of angiotensin II receptor blocker and losartan/hydrochlorothiazide combination on central blood pressure and augmentation index

    Hirohito Metoki, Hirohito Metoki, Taku Obara, Taku Obara, Taku Obara, Taku Obara, Kei Asayama, Kei Asayama, Kei Asayama, Michihiro Satoh, Michihiro Satoh, Miki Hosaka, Noha Elnagar, Yoshinori Miyawaki, Iwao Kojima, Takayoshi Ohkubo, Takayoshi Ohkubo, Takayoshi Ohkubo, Yutaka Imai, Yutaka Imai, Ryusuke Inoue, Junichiro Hashimoto, Masahiro Kikuya, Kazuhito Totsune, Motoya Nakagawa, Shigemichi Tanaka, Kotaro Nakamura, Nanako Hiwatari, Mutsuo Watanabe, Kenji Ito, Ruriko Mori, Hiroki Hoshi, Shuichi Sasaki, Daisuke Nakayama, Kouzou Ohta, Hiroshi Shishido, Youkou Emura, Hideo Odaka, Norihisa Kumasaka, Kazuteru Ohhira, Kuninobu Nihei, Kiyoto Ishibashi, Mitsutoshi Kato, Kiyoshi Uchiba, Masaaki Miyakawa, Hisao Mori, Takao Sugawara, Nobuhisa Yamada, Naoto Yagi, Yutaka Hatori, Tomoko Gomi, Toshio Ikeda, Takeshi Koitabashi, Shuji Arima, Masao Hiwatari

    Clinical and Experimental Hypertension 37 294-302 2015/07/01

    DOI: 10.3109/10641963.2014.960972  

    ISSN: 1064-1963

  28. 後期高齢者における脳卒中発症のリスク要因に関する検討

    MURAKAMI KEIKO, SATO TOMOHIRO, ASAYAMA KEI, INOUE RYUSUKE, METOKI HIROHITO, TSUBOTA MEGUMI, KIKUYA MASAHIRO, MURAKAMI TAKAHISA, IMAI JUN, OKUBO TAKAYOSHI

    日本循環器病予防学会誌 50 (2) 120-120 2015/06/01

    Publisher: (一社)日本循環器病予防学会

    ISSN: 1346-6267

  29. レセプトデータを用いた東北大学病院の本態性高血圧患者における降圧薬の処方動向調査

    黒澤 桂子, 佐藤 倫広, 飯田 優太郎, 小原 拓, 松浦 正樹, 井上 隆輔, 高橋 信行, 佐藤 博, 村井 ユリ子, 眞野 成康

    日本薬学会年会要旨集 135年会 (4) 134-134 2015/03

    Publisher: (公社)日本薬学会

    ISSN: 0918-9823

  30. 本態性高血圧患者における家庭血圧と脳心血管疾患発症リスクの男女別解析 HOMED-BP研究

    保坂 実樹, 浅山 敬, 佐藤 倫広, 井上 隆輔, 小原 拓, 目時 弘仁, 菊谷 昌浩, 大久保 孝義, 今井 潤

    日本高血圧学会総会プログラム・抄録集 37回 376-376 2014/10

    Publisher: (NPO)日本高血圧学会

  31. DIFFERENCE IN LIVING FORMS ASSOCIATED WITH POOR DIETARY INTAKE AMONG JAPANESE ELDERLY: THE OHASAMA STUDY

    M. Tsubota-Utsugi, M. Kikuya, M. Satoh, R. Inoue, M. Hosaka, H. Metoki, N. Fukushima, T. Hirose, K. Asayama, Y. Imai, T. Ohkubo

    INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE 21 S68-S69 2014/08

    ISSN: 1070-5503

    eISSN: 1532-7558

  32. 家庭血圧に基づく血漿アルドステロン濃度/血漿レニン活性化とNon‐dippingの関連―大迫研究―

    SATO TOMOHIRO, HOSAKA MIKI, KIKUYA MASAHIRO, ASAYAMA KEI, INOUE RYUSUKE, TSUBOTA MEGUMI, HARA AZUSA, HIROSE TAKUO, OHARA TAKU, METOKI HIROHITO, TOTSUNE KAZUHITO, HOSHI HARUHISA, MANO NARIYASU, IMAI JUN, OKUBO TAKAYOSHI

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集 3rd 115 2014/05/24

  33. Risk Stratification by Self-Measured Home Blood Pressure across Categories of Conventional Blood Pressure: A Participant-Level Meta-Analysis

    Kei Asayama, Kei Asayama, Lutgarde Thijs, Jana Brguljan-Hitij, Teemu J. Niiranen, Teemu J. Niiranen, Atsushi Hozawa, José Boggia, Lucas S. Aparicio, Lucas S. Aparicio, Azusa Hara, Jouni K. Johansson, Takayoshi Ohkubo, Christophe Tzourio, George S. Stergiou, Edgardo Sandoya, Ichiro Tsuji, Antti M. Jula, Yutaka Imai, Jan A. Staessen, Jan A. Staessen, K. Asayama, T. Ohkubo, M. Kikuya, R. Inoue, M. Satoh, M. Hosaka, M. T. Utsugi, T. Hirose, A. Hara, N. Fukushima, T. Obara, H. Metoki, Y. Imai, T. Niiranen, J. Johansson, A. Reunanen, A. Jula, K. Ohmori-Matsuda, S. Kuriyama, M. Kakizaki, A. Hozawa, I. Tsuji, G. Stergiou, A. Kollias, G. Thomopoulou, P. Kalogeropoulos, I. Skeva, E. Nasothimiou, N. Pantazis, N. Baibas, T. Mountokalakis, J. Boggia, E. Sandoya, J. A. Staessen, L. Thijs, N. Cauwenberghs, Z. Zhang, F. Wei, J. Knez, A. Odili, Y. Gu, Y. Liu, Y. Jin, L. Jacobs, T. Kuznetzova

    PLoS Medicine 11 2014/01/01

    DOI: 10.1371/journal.pmed.1001591  

    ISSN: 1549-1277

  34. 一般地域住民における,家庭血圧および24時間血圧に基づく真性および部分白衣高血圧と脳卒中発症の関連―大迫研究―

    佐藤倫広, 菊谷昌浩, 浅山敬, 井上隆輔, 宇津木(坪田, 恵, 原梓, 廣瀬卓男, 小原拓, 目時弘仁, 戸恒和人, 星晴久, 眞野成康, 今井潤, 大久保孝義

    日本高血圧学会総会プログラム・抄録集 36th 321-321 2013/10/24

    Publisher: (NPO)日本高血圧学会

  35. 微量アルブミン尿を呈する高血圧症患者に対するイルベサルタン単独治療および併用治療が腎機能,家庭血圧に及ぼす効果:多施設共同無作為比較研究(J‐HOMEアルブミン研究)

    井上隆輔, 大久保孝義, 菊谷昌浩, 目時弘仁, 小原拓, 佐藤倫広, 今井潤

    日本高血圧学会総会プログラム・抄録集 36th 269-269 2013/10/24

    Publisher: (NPO)日本高血圧学会

  36. 一般地域住民におけるセルフメディケーションに関する実態調査

    岩森紗希, 松本章裕, 佐藤倫広, 原梓, 菊谷昌浩, 小原拓, 目時弘仁, 廣瀬卓男, 井上隆輔, 浅山敬, 高橋信行, 眞野成康, 佐藤博, 今井潤, 大久保孝義

    日本医療薬学会年会講演要旨集 23rd 354 2013/08/28

  37. 治療中高血圧患者の高血圧管理における保険調剤薬局の関与:J‐HOME‐Morning研究

    小原拓, 小林由香, 池田うらら, 保坂実樹, 佐藤倫広, 菊谷昌浩, 目時弘仁, 井上隆輔, 大久保孝義, 眞野成康, 栗山進一, 今井潤

    日本医療薬学会年会講演要旨集 23rd 405 2013/08/28

  38. 一般住民における血漿アルドステロン濃度/血漿レニン活性比(ARR)と高血圧発症の関連 大迫研究

    佐藤 倫広, 菊谷 昌浩, 大久保 孝義, 森 建文, 宇津木 恵, 田, 目時 弘仁, 廣瀬 卓男, 原 梓, 小原 拓, 井上 隆輔, 浅山 敬, 戸恒 和人, 星 晴久, 今井 潤

    日本高血圧学会総会プログラム・抄録集 35回 394-394 2012/09

    Publisher: (NPO)日本高血圧学会

  39. 同居家族の喫煙は脳卒中発症の危険因子である 大迫研究

    井上 隆輔, 大久保 孝義, 菊谷 昌浩, 関 真美, 浅山 敬, 目時 弘仁, 小原 拓, 廣瀬 卓男, 原 梓, 橋本 貴尚, 佐藤 倫広, 星 晴久, 戸恒 和人, 根東 義明, 今井 潤

    日本高血圧学会総会プログラム・抄録集 35回 400-400 2012/09

    Publisher: (NPO)日本高血圧学会

  40. 新生児の血圧分布に関する研究 BOSHI 新生児研究

    井上 隆輔, 目時 弘仁, 大久保 孝義, 小原 拓, 菊谷 昌浩, 多田 秀子, 八木橋 香津代, 田中 耕平, 星 和彦, 森 滋, 鈴木 雅洲, 今井 潤

    日本高血圧学会総会プログラム・抄録集 35回 410-410 2012/09

    Publisher: (NPO)日本高血圧学会

  41. 左室肥大と家庭血圧に基づく治療抵抗性高血圧との関連 J-HOME-Morning研究

    小林 由香, 小原 拓, 大久保 孝義, 菊谷 昌浩, 井上 隆輔, 目時 弘仁, 池田 うらら, 佐藤 博, 今井 潤

    日本高血圧学会総会プログラム・抄録集 35回 411-411 2012/09

    Publisher: (NPO)日本高血圧学会

  42. PLASMA RENIN ACTIVITY AND ALDOSTERONE-TO-RENIN RATIO ARE ASSOCIATED WITH THE DEVELOPMENT OF CHRONIC KIDNEY DISEASE: THE OHASAMA STUDY Peer-reviewed

    Satoh Michihiro, Terata Shiho, Kikuya Masahiro, Ohkubo Takayoshi, Hashimoto Takanao, Hara Azusa, Hirose Takuo, Obara Taku, Metoki Hirohito, Inoue Ryusuke, Asayama Kei, Nakayama Masaaki, Kanno Atsuhiro, Totsune Kazuhito, Hoshi Haruhisa, Satoh Hiroshi, Sato Hiroshi, Imai Yutaka

    NEPHROLOGY DIALYSIS TRANSPLANTATION 27 121 2012/05

    ISSN: 0931-0509

  43. 慢性腎臓病の病気分類からみた超音波ドプラ検査による大動脈・腎内血流評価について

    阿部 倫明, 小泉 賢治, 山本 多恵, 井上 隆輔, 清元 秀泰, 宮崎 真理子, 森 建文, 佐藤 博, 伊藤 貞嘉

    超音波医学 39 (Suppl.) S399-S399 2012/04

    Publisher: (公社)日本超音波医学会

    DOI: 10.3179/jjmu.39.399  

    ISSN: 1346-1176

  44. 治療中高血圧患者の高血圧管理における保険調剤薬局の関与 J-HOME-Morning研究より

    小原 拓, 小林 由香, 池田 うらら, 菊谷 昌浩, 目時 弘仁, 井上 隆輔, 大久保 孝義, 眞野 成康, 栗山 進一, 今井 潤

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集 1回 101-101 2012/04

    Publisher: (NPO)日本高血圧学会

  45. 電子血圧計を用いた客観的な高血圧治療に関する研究(HOMED-BP研究) 主結果報告

    大久保 孝義, 浅山 敬, 井上 隆輔, 小原 拓, 目時 弘仁, 菊谷 昌浩, 三浦 幸雄, Staessen Jan A, 今井 潤, HOMED-BP研究グループ

    日本高血圧学会総会プログラム・抄録集 34回 323-323 2011/10

    Publisher: (NPO)日本高血圧学会

  46. 電子血圧計を用いた客観的な高血圧治療に関する研究(HOMED-BP研究) 家庭血圧降圧レベルと予後との関連

    浅山 敬, 大久保 孝義, 井上 隆輔, 小原 拓, 目時 弘仁, 菊谷 昌浩, 三浦 幸雄, Staessen Jan A, 今井 潤, HOMED-BP研究グループ

    日本高血圧学会総会プログラム・抄録集 34回 327-327 2011/10

    Publisher: (NPO)日本高血圧学会

  47. 家庭血圧・血圧日間変動と認知機能低下との関連 大迫研究

    松本 章裕, 佐藤 倫広, 菊谷 昌浩, 大久保 孝義, 橋本 貴尚, 原 梓, 目時 弘仁, 廣瀬 卓男, 小原 拓, 井上 隆輔, 浅山 敬, 戸恒 和人, 星 晴久, 佐藤 洋, 佐藤 博, 今井 潤

    日本高血圧学会総会プログラム・抄録集 34回 372-372 2011/10

    Publisher: (NPO)日本高血圧学会

  48. 喫煙習慣は男性における家庭血圧値・血圧日間変動の脳卒中発症リスクを上昇させるか? 大迫研究

    橋本 貴尚, 菊谷 昌浩, 大久保 孝義, 佐藤 倫広, 目時 弘仁, 井上 隆輔, 浅山 敬, 菅野 厚博, 小原 拓, 廣瀬 卓男, 星 晴久, 戸恒 和人, 佐藤 洋, 佐藤 博, 今井 潤

    日本高血圧学会総会プログラム・抄録集 34回 477-477 2011/10

    Publisher: (NPO)日本高血圧学会

  49. 一般住民における血漿アルドステロン/血漿レニン活性比(ARR)とnon-dippingおよびNa排泄量との関連 大迫研究

    佐藤 倫広, 菊谷 昌浩, 大久保 孝義, 森 建文, 橋本 貴尚, 目時 弘仁, 原 梓, 坪田 恵, 廣瀬 卓男, 小原 拓, 井上 隆輔, 浅山 敬, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集 34回 518-518 2011/10

    Publisher: (NPO)日本高血圧学会

  50. 血漿アルドステロン/レニン比とCKD発症に関する縦断的検討 大迫研究

    寺田 志保, 菊谷 昌浩, 佐藤 倫広, 大久保 孝義, 橋本 貴尚, 原 梓, 廣瀬 卓男, 目時 弘仁, 井上 隆輔, 小原 拓, 浅山 敬, 星 晴久, 戸恒 和人, 佐藤 洋, 佐藤 博, 今井 潤

    日本高血圧学会総会プログラム・抄録集 34回 520-520 2011/10

    Publisher: (NPO)日本高血圧学会

  51. 同居家族の喫煙は家庭高血圧発症の危険因子である 大迫研究

    井上 隆輔, 大久保 孝義, 菊谷 昌浩, 関 真美, 浅山 敬, 目時 弘仁, 小原 拓, 廣瀬 卓男, 原 梓, 橋本 貴尚, 佐藤 倫広, 星 晴久, 戸恒 和人, 佐藤 洋, 根東 義明, 今井 潤

    日本高血圧学会総会プログラム・抄録集 34回 527-527 2011/10

    Publisher: (NPO)日本高血圧学会

  52. 家庭血圧によるHome Arterial Stiffness Index(HASI)と頸動脈病変との関連 大迫研究

    菊谷 昌浩, 大久保 孝義, 佐藤 倫広, 橋本 貴尚, 原 梓, 廣瀬 卓男, 目時 弘仁, 井上 隆輔, 小原 拓, 浅山 敬, 星 晴久, 戸恒 和人, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集 34回 528-528 2011/10

    Publisher: (NPO)日本高血圧学会

  53. P2-138 ロサルタン/ヒドロクロロチアジド合剤の医療経済学的評価 : 家庭血圧を用いた検討(一般演題 ポスター発表,薬剤疫学・医療経済,臨床から学び臨床へと還元する医療薬学)

    佐藤 慶子, 大久保 孝義, 小林 慎, 目時 弘仁, 小原 拓, 浅山 敬, 井上 隆輔, 佐藤 博, 今井 潤

    日本医療薬学会年会講演要旨集 20 413-413 2010/10/25

    Publisher: 日本医療薬学会

  54. 一般住民における血清アルドステロン/血漿レニン活性比(ARR)と脳卒中発症およびNa摂取量との関連 大迫研究

    佐藤 倫広, 菊谷 昌浩, 原 梓, 大久保 孝義, 森 建文, 目時 弘仁, 宇津木 恵, 廣瀬 卓男, 小原 拓, 井上 隆輔, 浅山 敬, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集 33回 236-236 2010/10

    Publisher: (NPO)日本高血圧学会

  55. 電子血圧計を用いた客観的な高血圧治療に関する研究(HOMED-BP研究) 対象者のベースライン特性 HOMED-BP研究グループを代表して

    大久保 孝義, 浅山 敬, 高橋 ちひろ, 井上 隆輔, 目時 弘仁, 小原 拓, 三浦 幸雄, 今井 潤

    日本高血圧学会総会プログラム・抄録集 33回 273-273 2010/10

    Publisher: (NPO)日本高血圧学会

  56. 降圧治療中患者における家庭血圧管理と腎機能低下に関する縦断的検討 J-HOME-Morning研究

    石倉 一樹, 小原 拓, 吉田 愛琴, 池田 うらら, 目時 弘仁, 井上 隆輔, 浅山 敬, 中山 昌明, 菊谷 昌浩, 大久保 孝義, 今井 潤, J-HOME-Mornig研究グループ

    日本高血圧学会総会プログラム・抄録集 33回 277-277 2010/10

    Publisher: (NPO)日本高血圧学会

  57. 受動喫煙の家庭血圧に対する影響 大迫研究

    関 真美, 井上 隆輔, 大久保 孝義, 菊谷 昌浩, 目時 弘仁, 浅山 敬, 原 梓, 廣瀬 卓男, 菅野 厚博, 小原 拓, 橋本 貴尚, 星 晴久, 戸恒 和人, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集 33回 281-281 2010/10

    Publisher: (NPO)日本高血圧学会

  58. 家庭血圧によるHome Arterial Stiffness Index(HASI)の脳卒中発症予測能

    菊谷 昌浩, 大久保 孝義, 佐藤 倫広, 廣瀬 卓男, 橋本 貴尚, 目時 弘仁, 井上 隆輔, 小原 拓, 浅山 敬, 星 晴久, 戸恒 和人, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集 33回 283-283 2010/10

    Publisher: (NPO)日本高血圧学会

  59. 家庭血圧を指標とする降圧薬反応性のゲノムワイド解析 HOMED-BP-GENE研究

    勝谷 友宏, 浅山 敬, 大久保 孝義, 杉本 研, 神出 計, 井上 隆輔, 目時 弘仁, 小原 拓, 大石 充, 森下 竜一, 荻原 俊男, 今井 潤, 楽木 宏実

    日本高血圧学会総会プログラム・抄録集 33回 333-333 2010/10

    Publisher: (NPO)日本高血圧学会

  60. 家庭血圧測定に基づくカルシウム拮抗薬シルニジピンの降圧効果および薬効持続の検討

    吉田 愛琴, 小原 拓, 石倉 一樹, 佐々木 彩乃, 池田 うらら, 目時 弘仁, 浅山 敬, 井上 隆輔, 菊谷 昌浩, 大久保 孝義, 眞野 成康, 今井 潤

    日本高血圧学会総会プログラム・抄録集 33回 372-372 2010/10

    Publisher: (NPO)日本高血圧学会

  61. カルシウム拮抗薬・アンジオテンシン変換酵素阻害薬・アンジオテンシンII受容体拮抗薬の単剤服用者への、利尿薬併用効果に関する利尿薬種別・用量別検討 HOMED-BP研究サブ分析

    高橋 ちひろ, 浅山 敬, 井上 隆輔, 大久保 孝義, 目時 弘仁, 小原 拓, 三浦 幸雄, 佐藤 博, 今井 潤

    日本高血圧学会総会プログラム・抄録集 33回 378-378 2010/10

    Publisher: (NPO)日本高血圧学会

  62. High green tea consumption is associated with lower risk of silent lacunar infarcts: The OHASAMA study

    M. Tsubota-Utsugi, T. Ohkubo, A. Hara, M. Kikuya, T. Kondo, H. Metoki, R. Inoue, K. Asayama, S. Izumi, Y. Imai

    EUROPEAN HEART JOURNAL 31 685-685 2010/09

    ISSN: 0195-668X

  63. BIRTH-WEIGHT PREDICTS THE HOME BLOOD PRESSURE IN CHILDREN 7 YEARS OF AGE: FROM THE TOHOKU STUDY OF CHILD DEVELOPMENT (TSCD)

    K. Asayama, K. Hayashi, T. Ohkubo, A. Kanno, A. Hara, T. Hirose, T. Obara, H. Metoki, R. Inoue, M. Kikuya, K. Nakai, Y. Imai, H. Satoh

    JOURNAL OF HYPERTENSION 28 E78-E79 2010/06

    ISSN: 0263-6352

  64. 家庭血圧・自由行動下血圧に基づく循環器病の予防戦略 大迫研究 Peer-reviewed

    今井 潤, 浅山 敬, 井上 隆輔, 小原 拓, 菊谷 昌浩, 大久保 孝義

    日本循環器病予防学会誌 44巻 (3号) 200-212 2010/01

    ISSN: 1346-6267

    More details Close

    1986年から開始され、循環器疾患の包括的な疫学研究に成長した岩手県花巻市における大迫(おおはさま)研究は、常に臨床的視点に立脚した循環器疫学研究として遂行されてきた。本研究は、家庭自己測定血圧(家庭血圧)および自由行動下血圧(ABP)測定(ABPM)に基づく循環器疫学研究という希有な特徴を有することから、これまでに家庭血圧、自由行動下血圧と脳血管疾患を含む循環器疾患の関係に関する多くのエビデンスを発信し続けてきた。その結果、世界の主要な高血圧ガイドラインが提唱している家庭血圧、自由行動下血圧の高血圧、正常血圧基準値の根拠を形成してきた。本稿では大迫研究の成り立ちと、その実践を中心に概説し、研究の進行状況、横断的研究成果、並びにこの23年の縦断的研究の成果につき概説する。(著者抄録)

  65. Serum magnesium, ambulatory blood pressure, and the prevalence of carotid artery alteration: The Ohasama study

    T. Hashimoto, A. Hara, T. Ohkubo, M. Kikuya, Y. Shintani, H. Metoki, R. Inoue, K. Asayama, A. Kanno, M. Nakashita, T. Obara, K. Totsune, H. Hoshi, H. Sato, Y. Imai

    INTERNATIONAL JOURNAL OF CARDIOLOGY 137 S145-S145 2009/10

    DOI: 10.1016/j.ijcard.2009.09.499  

    ISSN: 0167-5273

  66. 仮面・白衣高血圧と慢性腎臓病との関連 24時間自由行動下血圧測定を用いた検討 大迫研究より

    菅野 厚博, 目時 弘仁, 菊谷 昌浩, 浅山 敬, 井上 隆輔, 寺脇 博之, 中山 昌明, 宍戸 洋, 戸恒 和人, 大久保 孝義, 今井 潤

    日本高血圧学会総会プログラム・抄録集 32回 154-154 2009/10

    Publisher: (NPO)日本高血圧学会

  67. 白衣効果と脳卒中発症 大迫研究

    井上 隆輔, 大久保 孝義, 菊谷 昌浩, 目時 弘仁, 浅山 敬, 原 梓, 廣瀬 卓男, 菅野 厚博, 小原 拓, 星 晴久, 戸恒 和人, 佐藤 洋, 根東 義明, 今井 潤

    日本高血圧学会総会プログラム・抄録集 32回 159-159 2009/10

    Publisher: (NPO)日本高血圧学会

  68. 電子血圧計を用いた客観的な高血圧治療に関する研究(HOMED-BP研究) 終了予定変更とその根拠

    大久保 孝義, 浅山 敬, 井上 隆輔, 目時 弘仁, 小原 拓, 三浦 幸雄, 今井 潤

    日本高血圧学会総会プログラム・抄録集 32回 206-206 2009/10

    Publisher: (NPO)日本高血圧学会

  69. 家庭血圧と頸動脈病変進展との関連 大迫研究

    原 梓, 大久保 孝義, 菊谷 昌浩, 橋本 貴尚, 中下 愛実, 寺田 志保, 目時 弘仁, 井上 隆輔, 浅山 敬, 菅野 厚博, 廣瀬 卓男, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集 32回 213-213 2009/10

    Publisher: (NPO)日本高血圧学会

  70. 高齢者高血圧患者における早朝家庭血圧管理と降圧治療 J-HOME-Elderly研究

    小原 拓, 芝宮 拓, 新木 貴大, 目時 弘仁, 浅山 敬, 井上 隆輔, 菊谷 昌浩, 大久保 孝義, 眞野 成康, 今井 潤

    日本高血圧学会総会プログラム・抄録集 32回 214-214 2009/10

    Publisher: (NPO)日本高血圧学会

  71. 飲酒習慣が血圧日内変動に及ぼす影響 大迫研究

    中下 愛実, 大久保 孝義, 原 梓, 菊谷 昌浩, 目時 弘仁, 宇津木 恵, 浅山 敬, 井上 隆輔, 菅野 厚博, 橋本 貴尚, 小原 拓, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集 32回 239-239 2009/10

    Publisher: (NPO)日本高血圧学会

  72. 治療中高血圧患者における家庭血圧コントロール改善・悪化の要因に関する検討 J-HOME-Morning研究

    小原 拓, 小林 満, 芝宮 拓, 新木 貴大, 原 梓, 目時 弘仁, 浅山 敬, 井上 隆輔, 菊谷 昌浩, 眞野 成康, 大久保 孝義, 今井 潤

    日本高血圧学会総会プログラム・抄録集 32回 263-263 2009/10

    Publisher: (NPO)日本高血圧学会

  73. 血漿アルドステロン/レニン活性比と高血圧有病およびNa摂取量との関連 家庭血圧を用いた検討(大迫研究)

    佐藤 倫広, 菊谷 昌浩, 原 梓, 大久保 孝義, 森 建文, 目時 弘仁, 宇津木 恵, 井上 隆輔, 浅山 敬, 小原 拓, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集 32回 318-318 2009/10

    Publisher: (NPO)日本高血圧学会

  74. 【高齢者高血圧 ガイドラインと今後の課題】 高齢者高血圧の疫学 (Geriatric Medicine)

    井上隆輔, 今井潤

    Geriatric Medicine 47 (7) 831-834 2009/07

  75. STROKE RISK IN TREATED HYPERTENSION BASED ON HOME BLOOD PRESSURE: THE OHASAMA STUDY

    D. Yasui, K. Asayama, T. Ohkubo, A. Kanno, A. Hara, T. Hirose, T. Obara, H. Metoki, R. Inoue, M. Kikuya, K. Totsune, H. Satoh, Y. Imai

    JOURNAL OF HYPERTENSION 27 S24-S24 2009/06

    ISSN: 0263-6352

  76. INFLUENCE OF HOME BLOOD PRESSURE MEASURING CONDITION IN EVENING ON THE MORNING-EVENING HOME BLOOD PRESSURE DIFFERENCE IN TREATED HYPERTENSIVE PATIENTS; THE J-HOME STUDY

    T. Obara, K. Ito, T. Ohkubo, K. Gonokami, T. Shibamiya, T. Shinki, M. Nakashita, A. Hara, H. Metoki, K. Asayama, R. Inoue, M. Kikuya, N. Mano, Y. Imai

    JOURNAL OF HYPERTENSION 27 S190-S190 2009/06

    ISSN: 0263-6352

  77. PROPOSAL OF COMMUNITY-BASED HOME BLOOD PRESSURE CRITERIA IN RELATION TO ANTIHYPERTENSIVE MEDICATION: THE OHASAMA STUDY

    K. Asayama, D. Yasui, T. Ohkubo, A. Kanno, A. Hara, T. Hirose, T. Obara, H. Metoki, R. Inoue, M. Kikuya, K. Totsune, H. Satoh, Y. Imai

    JOURNAL OF HYPERTENSION 27 S337-S337 2009/06

    ISSN: 0263-6352

  78. CHARACTERISTICS OF UNCONTROLLED HYPERTENSIVE PATIENTS DETERMINED BY MORNING AND EVENING HOME BLOOD PRESSURE MEASUREMENT FROM THE J-HOME STUDY

    T. Obara, K. Ito, T. Ohkubo, K. Gonokami, T. Shibamiya, T. Shinki, A. Hara, H. Metoki, K. Asayama, R. Inoue, M. Kikuya, N. Mano, Y. Imai

    JOURNAL OF HYPERTENSION 27 S259-S259 2009/06

    ISSN: 0263-6352

  79. 【後期高齢者・超高齢者の降圧治療】 病態と疫学研究 (血圧)

    井上隆輔, 大久保孝義, 今井潤

    血圧 15 (11) 942-946 2008/11

  80. Genome-Wide Association Study for the Response to Antihypertensive Medication: HOMED-BP-GENE Study Peer-reviewed

    Katsuya Tomohiro, Asayama Kei, Inoue Ryusuke, Sugimoto Ken, Ohkubo Takayoshi, Metoki Hirohito, Obara Taku, Ishiakwa Kazuhiko, Fujisawa Tomomi, Ohishi Mitsuru, Ogihara Toshio, Imai Yutaka, Rakugi Hiromi

    CIRCULATION 118 (18) S890 2008/10/28

    ISSN: 0009-7322

  81. 家庭血圧を用いた高血圧発症予測遺伝子多型の同定 大迫研究における12年の追跡から

    渡邉 悠美子, 目時 弘仁, 大久保 孝義, 勝谷 友宏, 田原 康玄, 菊谷 昌浩, 廣瀬 卓男, 杉本 研, 浅山 敬, 井上 隆輔, 原 梓, 小原 拓, 橋本 潤一郎, 名倉 潤, 小原 克彦, 戸恒 和人, 荻原 俊男, 樂木 宏実, 三木 哲郎, 今井 潤

    日本高血圧学会総会プログラム・抄録集 31回 207-207 2008/10

    Publisher: (NPO)日本高血圧学会

  82. 家庭血圧導入の医療経済学的評価 外来血圧コントロール良好高血圧患者における検討

    田巻 佑一朗, 中川 美和, 大久保 孝義, 小林 慎, 福永 英史, 菊谷 昌浩, 小原 拓, 原 梓, 浅山 敬, 目時 弘仁, 井上 隆輔, 橋本 潤一郎, 戸恒 和人, 今井 潤

    日本高血圧学会総会プログラム・抄録集 31回 207-207 2008/10

    Publisher: (NPO)日本高血圧学会

  83. 高血圧治療ガイドラインに基づいたリスク分類 大迫研究

    浅山 敬, 大久保 孝義, 菊谷 昌浩, 廣瀬 卓男, 原 梓, 菅野 厚博, 安井 大策, 小原 拓, 目時 弘仁, 井上 隆輔, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集 31回 208-208 2008/10

    Publisher: (NPO)日本高血圧学会

  84. 自由行動下心拍短期変動と家庭心拍日間変動の規定要因に関する検討 大迫研究

    後ノ上 健太, 菊谷 昌浩, 大久保 孝義, 原 梓, 目時 弘仁, 浅山 敬, 井上 隆輔, 小原 拓, 廣瀬 卓男, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集 31回 214-214 2008/10

    Publisher: (NPO)日本高血圧学会

  85. 降圧治療と関連する遺伝因子のゲノムスキャン HOMED-BP-GENE研究

    勝谷 友宏, 浅山 敬, 大久保 孝義, 杉本 研, 井上 隆輔, 目時 弘仁, 小原 拓, 石川 一彦, 藤澤 智巳, 大石 充, 荻原 俊男, 今井 潤, 樂木 宏実

    日本高血圧学会総会プログラム・抄録集 31回 262-262 2008/10

    Publisher: (NPO)日本高血圧学会

  86. AASIおよび24時間脈圧の再現性・予後予測能 全血圧値および一部の血圧値による検討 大迫研究

    菊谷 昌浩, Staessen Jan A, 大久保 孝義, Thijs Lutgarde, 目時 弘仁, 浅山 敬, 小原 拓, 井上 隆輔, Li Yan, Dolan Eamon, 星 晴久, 橋本 潤一郎, 戸恒 和人, 佐藤 洋, Wang Ji-Guang, O'Brien Eoin, 今井 潤

    日本高血圧学会総会プログラム・抄録集 31回 284-284 2008/10

    Publisher: (NPO)日本高血圧学会

  87. 血清マグネシウム濃度・24時間自由行動下血圧と頸動脈硬化指標との関連 大迫研究

    橋本 貴尚, 原 梓, 大久保 孝義, 菊谷 昌浩, 新谷 依子, 目時 弘仁, 井上 隆輔, 浅山 敬, 菅野 厚博, 中下 愛実, 小原 拓, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集 31回 285-285 2008/10

    Publisher: (NPO)日本高血圧学会

  88. 家庭ダブルプロダクトと予後 大迫研究より

    井上 隆輔, 大久保 孝義, 菊谷 昌浩, 浅山 敬, 目時 弘仁, 原 梓, 廣瀬 卓男, 菅野 厚博, 小原 拓, 星 晴久, 橋本 潤一郎, 戸恒 和人, 佐藤 洋, 根東 義明, 今井 潤

    日本高血圧学会総会プログラム・抄録集 31回 286-286 2008/10

    Publisher: (NPO)日本高血圧学会

  89. 非飲酒者における就寝前家庭血圧の有用性 大迫研究

    浅山 敬, 大久保 孝義, 菅野 厚博, 原 梓, 廣瀬 卓男, 安井 大策, 小原 拓, 目時 弘仁, 井上 隆輔, 菊谷 昌浩, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集 31回 313-313 2008/10

    Publisher: (NPO)日本高血圧学会

  90. Cost-effectiveness of the introduction of home blood pressure measurement in patients with office hypertension

    H. Fukunaga, T. Ohkubo, M. Kobayashi, Y. Tamaki, M. Kikuya, T. Obara, M. Nakagawa, A. Hara, K. Asayama, H. Metoki, R. Inoue, J. Hashimoto, K. Totsune, Y. Imai

    JOURNAL OF HYPERTENSION 26 S488-S488 2008/06

    ISSN: 0263-6352

  91. Evening home blood pressure predicts stroke risk independent of morning home blood pressure among non-drinkers: The Ohasama study

    K. Asayama, T. Ohkubo, A. Kanno, A. Hara, T. Hirose, D. Yasui, T. Obara, H. Metoki, R. Inoue, M. Kikuya, J. Hashimoto, K. Totsune, H. Satoh, Y. Imai

    JOURNAL OF HYPERTENSION 26 S93-S93 2008/06

    ISSN: 0263-6352

  92. Ambulatory versus home blood pressure - Which is more closely associated with silent cerebrovascular lesions and carotid atherosclerosis? The Ohasama study

    A. Hara, T. Ohkubo, T. Kondo, M. Kikuya, H. Metoki, K. Asayama, R. Inoue, T. Obara, J. Hashimoto, K. Totsune, H. Satoh, S. Izumi, Y. Imai

    JOURNAL OF HYPERTENSION 26 S503-S503 2008/06

    ISSN: 0263-6352

  93. Current status of home blood pressure measurement in Japan: Practice and awareness of 1,928 physicians

    T. Obara, T. Ohkubo, H. Hukunaga, K. Asayama, H. Metoki, R. Inoue, A. Hara, T. Hirose, M. Kikuya, J. Hashimoto, K. Totsune, Y. Imai

    JOURNAL OF HYPERTENSION 26 S510-S510 2008/06

    ISSN: 0263-6352

  94. 本邦の高血圧治療にJSH2004が与えた影響 J-HOME研究

    小原 拓, 大久保 孝義, 加藤 哲夫, 田中 宏治, 浅山 敬, 菊谷 昌浩, 目時 弘仁, 井上 隆輔, 原 梓, 橋本 潤一郎, 戸恒 和人, 今井 潤

    日本高血圧学会総会プログラム・抄録集 30回 153-153 2007/10

    Publisher: (NPO)日本高血圧学会

  95. 日本人のメタボリックシンドローム診断における家庭血圧の有用性ならびにウエスト周囲径基準値についての検討 大迫研究

    佐藤 敦, 浅山 敬, 大久保 孝義, 菊谷 昌浩, 小原 拓, 目時 弘仁, 井上 隆輔, 原 梓, 原 晴久, 橋本 潤一郎, 戸恒 和人, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集 30回 154-154 2007/10

    Publisher: (NPO)日本高血圧学会

  96. 家庭血圧による各血圧因子の持つ脳卒中発症予測能の比較 大迫研究

    井上 隆輔, 大久保 孝義, 菊谷 昌浩, 浅山 敬, 目時 弘仁, 小原 拓, 廣瀬 卓男, 原 梓, 森戸 里衣子, 星 晴久, 橋本 潤一郎, 戸恒 和人, 佐藤 洋, 根東 義明, 今井 潤

    日本高血圧学会総会プログラム・抄録集 30回 176-176 2007/10

    Publisher: (NPO)日本高血圧学会

  97. 一般住民における家庭血圧と慢性腎臓病との関連 大迫研究

    寺脇 博之, 目時 弘仁, 中山 昌明, 大久保 孝義, 菊谷 昌浩, 菅野 厚博, 大谷 陽範, 原 梓, 浅山 敬, 井上 隆輔, 中山 啓輔, 橋本 潤一郎, 戸恒 和人, 伊藤 貞嘉, 今井 潤

    日本高血圧学会総会プログラム・抄録集 30回 179-179 2007/10

    Publisher: (NPO)日本高血圧学会

  98. 随時血圧・自由行動下血圧・家庭血圧 頸動脈病変と最も強く関連しているのはどれか? 大迫研究

    田中 一翔, 原 梓, 大久保 孝義, 菊谷 昌浩, 目時 弘仁, 小原 拓, 大谷 陽範, 井上 隆輔, 浅山 敬, 森戸 里衣子, 廣瀬 卓男, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集 30回 180-180 2007/10

    Publisher: (NPO)日本高血圧学会

  99. (プロ)レニン受容体遺伝子多型と高血圧症との関連の検討 大迫研究

    橋本 和啓, 戸恒 和人, 廣瀬 卓男, 目時 弘仁, 渡邊 悠美子, 中繁 由紀子, 井上 隆輔, 浅山 敬, 菊谷 昌浩, 大久保 孝義, 橋本 潤一郎, 高橋 和広, 今井 潤

    日本高血圧学会総会プログラム・抄録集 30回 234-234 2007/10

    Publisher: (NPO)日本高血圧学会

  100. 降圧治療中患者において家庭血圧測定より得られた血圧日間変動の規定因子

    加藤 哲夫, 菊谷 昌浩, 小原 拓, 大久保 孝義, 原 梓, 目時 弘仁, 井上 隆輔, 浅山 敬, 廣瀬 卓男, 森戸 里衣子, 田中 宏治, 橋本 潤一郎, 戸恒 和人, 今井 潤

    日本高血圧学会総会プログラム・抄録集 30回 237-237 2007/10

    Publisher: (NPO)日本高血圧学会

  101. 若年女性における月経周期と家庭血圧・脈拍との関連

    目時 弘仁, 渡邉 悠美子, 西村 美里, 大久保 孝義, 菊谷 昌浩, 森戸 里衣子, 原 梓, 廣瀬 卓男, 田村 知子, 小原 拓, 菅野 厚博, 浅山 敬, 井上 隆輔, 橋本 潤一郎, 戸恒 和人, 今井 潤

    日本高血圧学会総会プログラム・抄録集 30回 238-238 2007/10

    Publisher: (NPO)日本高血圧学会

  102. 家庭血圧測定経験の有無と降圧治療 J-HOME研究より

    小原 拓, 大久保 孝義, 浅山 敬, 菊谷 昌浩, 目時 弘仁, 井上 隆輔, 加藤 哲夫, 田中 宏治, 原 梓, 橋本 潤一郎, 戸恒 和人, 今井 潤

    日本高血圧学会総会プログラム・抄録集 30回 250-250 2007/10

    Publisher: (NPO)日本高血圧学会

  103. 自由行動下血圧による血圧短期変動と家庭血圧による血圧日間変動 大迫研究

    菊谷 昌浩, 大久保 孝義, 目時 弘仁, 浅山 敬, 原 梓, 小原 拓, 井上 隆輔, 星 晴久, 橋本 潤一郎, 戸恒 和人, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集 30回 251-251 2007/10

    Publisher: (NPO)日本高血圧学会

  104. 大動脈硬化指標と微量アルブミン尿との関連 大迫研究

    石川 智史, 橋本 潤一郎, 森戸 里衣子, 相川 智之, 原 梓, 目時 弘仁, 井上 隆輔, 浅山 敬, 菊谷 昌浩, 大久保 孝義, 戸恒 和人, 今井 潤

    日本高血圧学会総会プログラム・抄録集 30回 253-253 2007/10

    Publisher: (NPO)日本高血圧学会

  105. 白衣高血圧・仮面高血圧における高感度C反応性蛋白 大迫研究

    原 梓, 大久保 孝義, 菊谷 昌浩, 目時 弘仁, 小原 拓, 大谷 陽範, 田中 一翔, 井上 隆輔, 浅山 敬, 森戸 里衣子, 廣瀬 卓男, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集 30回 264-264 2007/10

    Publisher: (NPO)日本高血圧学会

  106. 正常高値血圧のリスク評価と、高血圧治療ガイドラインへの家庭血圧導入の有用性 大迫研究

    浅山 敬, 大久保 孝義, 佐藤 敦, 菊谷 昌浩, 目時 弘仁, 井上 隆輔, 小原 拓, 原 梓, 廣瀬 卓男, 森戸 里衣子, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集 30回 270-270 2007/10

    Publisher: (NPO)日本高血圧学会

  107. 両親の長寿は子の低い血圧と関連する 大迫研究

    渡邉 悠美子, 目時 弘仁, 大久保 孝義, 廣瀬 卓男, 菊谷 昌浩, 浅山 敬, 井上 隆輔, 森戸 里衣子, 原 梓, 小原 拓, 星 晴久, 橋本 潤一郎, 戸恒 和人, 今井 潤

    日本高血圧学会総会プログラム・抄録集 30回 271-271 2007/10

    Publisher: (NPO)日本高血圧学会

  108. 腎機能障害と無症候性脳血管障害との関連 大迫研究

    大谷 陽範, 原 梓, 大久保 孝義, 菊谷 昌浩, 近藤 健男, 小原 拓, 目時 弘仁, 井上 隆輔, 浅山 敬, 菅野 厚博, 森戸 里衣子, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 出江 伸一, 今井 潤

    日本高血圧学会総会プログラム・抄録集 30回 277-277 2007/10

    Publisher: (NPO)日本高血圧学会

  109. 29-A3-14-5 降圧薬服用コンプライアンス不良者の特性及び生活習慣に関する研究(調剤・服薬指導・薬剤管理指導,社会の期待に応える医療薬学を)

    原 梓, 大久保 孝義, 菊谷 昌浩, 小原 拓, 田中 宏治, 目時 弘仁, 宇津木 恵, 井上 隆輔, 浅山 敬, 橋本 潤一郎, 戸恒 和人, 佐藤 洋, 今井 潤

    日本医療薬学会年会講演要旨集 17 190-190 2007/09/01

    Publisher: 日本医療薬学会

  110. 大迫研究(家庭血圧の重要性を世界に発信した) 縦断的研究によるエビデンス (BIO Clinica)

    井上隆輔, 大久保孝義, 今井潤

    BIO Clinica 22 (9) 831-835 2007/08

  111. Association of ambulatory blood pressure versus home blood pressure with the risk of silent cerebrovascular lesions in a general population: The Ohasama study

    A. Hara T. Ohkubo, T. Kondo, M. Kikuya, Y. Aono, T. Obara, H. Metoki, R. Inoue, K. Asayama, J. Hashimoto, K. Totsune, S. Izumi, Y. Imai

    JOURNAL OF HYPERTENSION 25 S163-S163 2007/06

    ISSN: 0263-6352

  112. Control conditions of blood pressure at home and in the office among elderly hypertensive patients without calcium channel blockers before and after JSH2004

    T. Obara, T. Ohkubo, K. Asayama, M. Kikuya, R. Inoue, A. Hara, J. Hashimoto, K. Totsune, Y. Imai

    JOURNAL OF HYPERTENSION 25 S300-S300 2007/06

    ISSN: 0263-6352

  113. Home blood pressure measurements associated with better blood pressure control: From the J-HOME study

    T. Obara, T. Ohkubo, K. Asayama, M. Kikuya, H. Metoki, R. Inoue, A. Hara, J. Hashimoto, K. Totsune, Y. Imai

    JOURNAL OF HYPERTENSION 25 S299-S299 2007/06

    ISSN: 0263-6352

  114. Prgnostic significance of nocturnal dipping for stroke and heart disease mortality risk: The Ohasama study

    H. Metoki, T. Ohkubo, M. Kikuya, K. Asayama, R. Inoue, A. Hara, T. Hirose, T. Obara, J. Hashimoto, K. Totsune, H. Hoshi, H. Satoh, Y. Imai

    JOURNAL OF HYPERTENSION 25 S168-S169 2007/06

    ISSN: 0263-6352

  115. Stroke prognosis of "masked hypertension" and "white-coat hypertension" detected by home blood pressure measurements: The Ohasama study

    T. Ohkubo, M. Kikuya, K. Asayama, T. Obara, H. Metoki, R. Inoue, A. Hara, T. Hirose, J. Hashimoto, K. Totsune, H. Hoshi, H. Satoh, Y. Imai

    JOURNAL OF HYPERTENSION 25 S3-S3 2007/06

    ISSN: 0263-6352

  116. The current status of heart rate measured at home among treated hypertensive patients: The Japan home versus office blood pressure measurement evaluation (J-HOME) study Peer-reviewed

    Rie Komai, Taku Obara, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Ryusuke Inoue, Takuya Oikawa, Kayo Murai, Tsuyoshi Horikawa, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

    JOURNAL OF HYPERTENSION 24 266-266 2006/12

    ISSN: 0263-6352

  117. The current usage of diuretics among hypertensive patients in Japan: the Japan home versus office blood pressure measurement evaluation (J-HOME) study Peer-reviewed

    Kayo Murai, Taku Obara, Takayoshi Ohkubo, Hirohito Metoki, Masahiro Kikuya, Ryusuke Inoue, Kei Asayama, Takuya Oikawa, Rie Komai, Tuyoshi Horikawa, Junichiro Hashimoto, Kazuhito Totsune, Yutaka Imai

    JOURNAL OF HYPERTENSION 24 260-260 2006/12

    ISSN: 0263-6352

  118. Home and office blood pressure control among elderly hypertensive patients without calcium channel blockers before and after JSH2004 Peer-reviewed

    Obara Taku, Ohkubo Takayoshi, Komai Rie, Murai Kayo, Metoki Hirohito, Inoue Ryusuke, Asayama Kei, Kikuya Masahiro, Hashimoto Junichiro, Totsune Kazuhito, Imai Yutaka

    JOURNAL OF HYPERTENSION 24 379 2006/12

    ISSN: 0263-6352

  119. Detection of silent cerebrovascular lesions in subjects with masked hypertension and white-coat hypertension by self-measured blood pressure at home: The Ohasama study Peer-reviewed

    Hara Azusa, Ohkubo Takayoshi, Kondo Takeo, Kikuya Masahiro, Aono Yoko, Obara Taku, Metoki Hirohito, Inoue Ryusuke, Asayama Kei, Shintani Yoriko, Hashimoto Junichiro, Totsune Kazuhito, Satoh Hiroshi, Izumi Shin-Ichi, Imai Yutaka

    JOURNAL OF HYPERTENSION 24 267 2006/12

    ISSN: 0263-6352

  120. Parental longevity and home blood pressure values in adult offspring: The Ohasama study Peer-reviewed

    Metoki Hirohito, Ohkubo Takayoshi, Watanabe Yumiko, Hirose Takuo, Kikuya Masahiro, Asayama Kei, Inoue Ryusuke, Hara Azusa, Obara Taku, Hoshi Haruhisa, Hashimoto Junichiro, Totsune Kazuhito, Imai Yutaka

    JOURNAL OF HYPERTENSION 24 241 2006/12

    ISSN: 0263-6352

  121. Development of new electronic drug compliance-monitoring device for one dose package (HCM-100) Peer-reviewed

    Obara Taku, Ohkubo Takayoshi, Murai Kayo, Komai Rie, Tanaka Kouji, Metoki Hirohito, Inoue Ryusuke, Asayama Kei, Kikuya Masahiro, Hashimoto Junichiro, Totsune Kazuhito, Imai Yutaka

    JOURNAL OF HYPERTENSION 24 220 2006/12

    ISSN: 0263-6352

  122. Ambulatory blood pressure, plasma fibrinogen, and silent cerebrovascular lesions: The ohasama study Peer-reviewed

    Aono Yoko, Ohkubo Takayoshi, Kikuya Masahiro, Hara Azusa, Kondo Takeo, Obara Taku, Metoki Hirohito, Inoue Ryusuke, Asayama Kei, Shintani Yoriko, Hashirnoto Junichiro, Totsune Kazuhito, Satoh Hiroshi, Izumi Shin-Ichi, Imai Yutaka

    JOURNAL OF HYPERTENSION 24 212 2006/12

    ISSN: 0263-6352

  123. Ambulatory blood pressure, blood pressure variability and the prevalence of carotid atherosclerosis: The ohasama study Peer-reviewed

    Shintani Yoriko, Kikuya Masahiro, Haral Azusa, Ohkubo Takayoshi, Metoki Hirohito, Asayama Kei, Inoue Ryusuke, Obara Taku, Aono Yoko, Hashimoto Takanao, Hashimoto Junichiro, Totsune Kazuhito, Hoshi Haruhisa, Satoh Hiroshi, Imai Yutaka

    JOURNAL OF HYPERTENSION 24 122-123 2006/12

    ISSN: 0263-6352

  124. Ambulatory arterial stiffness index and 24-hour ambulatory pulse pressure as predictors of mortality: Results from the ohasama study Peer-reviewed

    Kikuya Masahiro, Staessen Jan A, Ohkubo Takayoshi, Thijs Lutgarde, Metoki Hirohito, Asayama Kei, Obara Taku, Inoue Ryusuke, Li Yan, Dolan Eamon, Hoshi Haruhisa, Hashimoto Junichiro, Totsune Kazuhito, Satoh Hiroshi, Imai Yutaka

    JOURNAL OF HYPERTENSION 24 171 2006/12

    ISSN: 0263-6352

  125. Factors affecting day-by-day variability of self-measured blood pressure at home: The Ohasama study Peer-reviewed

    Kato Tetsuo, Kikuya Masahiro, Ohkubo Takayoshi, Hara Azusa, Metoki Hirohito, Asayama Kei, Inoue Ryusuke, Obara Taku, Hashimoto Junichiro, Totsune Kazuhito, Hoshi Haruhisa, Hiroshi Satoh, Imai Yutaka

    JOURNAL OF HYPERTENSION 24 87 2006/12

    ISSN: 0263-6352

  126. Comparison of stroke risk among subtypes of hypertension determined by 24-hour ambulatory blood pressure monitoring: The Ohasama study Peer-reviewed

    Inoue Ryusuke, Ohkubo Takayoshi, Kikuya Masahiro, Metoki Hirohito, Asayama Kei, Obara Taku, Hirose Takuo, Hara Azusa, Hoshi Haruhisa, Hashimoto Junichiro, Totsune Kazuhito, Satoh Hiroshi, Kondo Yoshiaki, Imai Yutaka

    JOURNAL OF HYPERTENSION 24 117 2006/12

    ISSN: 0263-6352

  127. 高校生における血圧値および高血圧基準値の認識に関する調査成績(05')

    小原 拓, 大久保 孝義, 目時 弘仁, 井上 隆輔, 浅山 敬, 菊谷 昌浩, 橋本 潤一郎, 戸恒 和人, 今井 潤

    Health Sciences 22 (4) 576-576 2006/10

    Publisher: 日本健康科学学会

    ISSN: 0911-7024

  128. 一般地域住民におけるサプリメント摂取者の人口学的特性及び生活習慣に関する研究

    原 梓, 大久保 孝義, 菊谷 昌浩, 小原 拓, 芝崎 貴子, 目時 弘仁, 井上 隆輔, 浅山 敬, 橋本 潤一郎, 戸恒 和人, 星 晴久, 細川 徹, 佐藤 洋, 今井 潤

    Health Sciences 22 (4) 606-606 2006/10

    Publisher: 日本健康科学学会

    ISSN: 0911-7024

  129. [Measurement and evaluation of blood pressure]. Peer-reviewed

    Inoue R, Ohkubo T, Kikuya M, Imai Y

    Nihon rinsho. Japanese journal of clinical medicine 64 Suppl 6 494-497 2006/08

    ISSN: 0047-1852

  130. 【高血圧 最新の研究動向】 臨床編 高血圧治療ガイドライン JSH2004 血圧の測定と評価 (日本臨床)

    井上隆輔, 大久保孝義, 菊谷昌浩, 今井潤

    日本臨床 64 (増刊6 高血圧(下)) 494-497 2006/08

  131. 診断の指針 治療の指針 「家庭血圧測定ガイドライン」と患者指導 (綜合臨床)

    井上隆輔, 大久保孝義, 菊谷昌浩, 今井潤

    綜合臨床 55 (5) 1533-1534 2006/05

  132. 本邦における利尿薬使用の現状

    村井 華代, 小原 拓, 大久保 孝義, 及川 卓也, 駒井 理恵, 堀川 剛, 菊谷 昌浩, 浅山 敬, 井上 隆輔, 目時 弘仁, 戸恒 和人, 橋本 潤一郎, 今井 潤

    日本薬学会年会要旨集 126年会 (2) 155-155 2006/03

    Publisher: (公社)日本薬学会

    ISSN: 0918-9823

  133. 朝晩の家庭血圧測定値の臨床的有用性 脳卒中発症予測能の観点から 大迫研究

    浅山 敬, 大久保 孝義, 小原 拓, 菊谷 昌浩, 目時 弘仁, 井上 隆輔, 星 晴久, 橋本 潤一郎, 戸恒 和人, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集 28回 32-32 2005/09

    Publisher: (NPO)日本高血圧学会

  134. 24時間自由行動下血圧測定から得られる4つの血圧因子(収縮期血圧,拡張期血圧,平均血圧および脈圧)の脳卒中発症予測能

    井上 隆輔, 大久保 孝義, 菊谷 昌浩, 浅山 敬, 目時 弘仁, 小原 拓, 橋本 潤一郎, 戸恒 和人, 星 晴久, 今井 潤

    日本高血圧学会総会プログラム・抄録集 28回 64-64 2005/09

    Publisher: (NPO)日本高血圧学会

  135. 白衣高血圧・仮面高血圧の頸動脈病変:大迫研究

    原 梓, 大久保 孝義, 菊谷 昌浩, 小原 拓, 目時 弘仁, 井上 隆輔, 浅山 敬, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集 28回 69-69 2005/09

    Publisher: (NPO)日本高血圧学会

  136. 自由行動下血圧測定による血圧短期変動および心拍短期変動の脳卒中予後予測能 大迫研究

    菊谷 昌浩, 大久保 孝義, 浅山 敬, 目時 弘仁, 井上 隆輔, 小原 拓, 橋本 潤一郎, 戸恒 和人, 星 晴久, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集 28回 182-182 2005/09

    Publisher: (NPO)日本高血圧学会

  137. 家庭血圧による夜間血圧,夜間血圧降下度の評価 大迫研究

    細畑 圭子, 菊谷 昌浩, 大久保 孝義, 浅山 敬, 目時 弘仁, 小原 拓, 井上 隆輔, 星 晴久, 橋本 潤一郎, 戸恒 和人, 佐藤 洋, 今井 潤

    日本高血圧学会総会プログラム・抄録集 28回 205-205 2005/09

    Publisher: (NPO)日本高血圧学会

  138. Prediction of stroke by four blood pressure indexes determined by 24-hour ambulatory blood pressure monitoring in a general population: The Ohasama Study

    R Inoue, T Ohkubo, M Kikuya, H Metoki, K Asayama, T Obara, H Hoshi, J Hashimoto, K Tostune, H Satoh, Y Kondc, Y Imai

    JOURNAL OF HYPERTENSION 23 S135-S135 2005/06

    ISSN: 0263-6352

  139. [Clinical significance of home blood pressure measurements for diagnosis of hypertension in the elderly]. Peer-reviewed

    Inoue R, Ohkubo T, Kikuya M, Imai Y

    Nihon rinsho. Japanese journal of clinical medicine 63 1005-1009 2005/06

    Publisher: 6

    ISSN: 0047-1852

  140. 【高齢者高血圧 病態と診断・治療の進歩】 高齢者高血圧の診断 高齢者高血圧の診断における家庭血圧測定の意義 (日本臨床)

    井上隆輔, 大久保孝義, 菊谷昌浩, 今井潤

    日本臨床 63 (6) 1005-1009 2005/06

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Presentations 11

  1. 新生児の血圧分布に関する研究:BOSHI-新生児研究

    井上隆輔, 目時弘仁, 大久保孝義, 小原拓, 菊谷昌浩, 多田秀子, 八木橋香津代, 田中耕平, 星和彦, 森滋, 鈴木雅洲, 今井潤

    第35回日本高血圧学会総会 2012/09/20

  2. 同居家族の喫煙は脳卒中発症の危険因子である:大迫研究

    井上隆輔, 大久保孝義, 菊谷昌浩, 関真美, 浅山敬, 目時弘仁, 小原拓, 廣瀬卓男, 原梓, 橋本貴尚, 佐藤倫広, 星晴久, 戸恒和人, 根東義明, 今井潤

    第35回日本高血圧学会総会 2012/09/20

  3. 同居家族の喫煙は家庭高血圧発症の危険因子である:大迫研究

    井上隆輔, 大久保孝義, 菊谷昌浩, 関真美, 浅山敬, 目時弘仁, 小原拓, 廣瀬卓男, 原梓, 橋本貴尚, 佐藤倫広, 星晴久, 戸恒和人, 佐藤洋, 根東義明, 今井潤

    第34回日本高血圧学会総会 2011/10/20

  4. 受動喫煙の家庭血圧に対する影響:大迫研究

    関真美, 井上隆輔, 大久保孝義, 菊谷昌浩, 目時弘仁, 浅山敬, 原梓, 廣瀬卓男, 菅野厚博, 小原拓, 橋本貴尚, 星晴久, 戸恒和人, 佐藤洋, 今井潤

    高血圧学会 2010/10/15

  5. 白衣効果と脳卒中発症:大迫研究

    井上隆輔, 大久保孝義, 菊谷昌浩, 目時弘仁, 浅山敬, 原梓, 広瀬卓男, 菅野厚博, 小原拓, 星晴久, 戸恒和人, 佐藤洋, 根東義明, 今井潤

    第32回日本高血圧学会総会 2009/10/01

  6. Large Scale Intervention Study to Hypertension with Information Technology: Hypertension Objective treatment based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) Study. International-presentation

    Inoue R, Nakayama M, Shibuya A, Ohkubo T, Asayama K, Metoki H, Tamura T, Kondo Y, Imai Y

    American Medical Informatics Association 2008 Annual Symposium 2008/11/08

  7. 家庭ダブルプロダクトと予後 大迫研究より

    井上隆輔, 大久保孝義, 菊谷昌浩, 浅山敬, 目時弘仁, 原梓, 廣瀬卓男, 菅野厚博, 小原拓, 星晴久, 橋本潤一郎, 戸恒和人, 佐藤洋, 根東義明, 今井潤

    第31回日本高血圧学会総会 2008/10/09

  8. 家庭血圧による各血圧因子の持つ脳卒中発症予測能の比較 大迫研究

    井上隆輔, 大久保孝義, 菊谷昌浩, 浅山敬, 目時弘仁, 小原拓, 廣瀬卓男, 原梓, 森戸里衣子, 星晴久, 橋本潤一郎, 戸恒和人, 佐藤洋, 根東義明, 今井潤

    第30回日本高血圧学会総会 2007/10/25

  9. Comparison of stroke risk among subtypes of hypertension determined by 24-hour ambulatory blood pressure monitoring: the Ohasama study International-presentation

    Inoue R, Ohkubo T, Kikuya M, Metoki H, Asayama K, Obara T, Hirose T, Hara A, Hoshi H, Hashimoto J, Totsune K, Satoh H, Kondo Y, Imai Y

    The 21st Scientific Meeting of the International Society of Hypertension 2006/10/15

  10. 24時間自由行動下血圧測定から得られる4つの血圧因子(収縮期血圧,拡張期血圧,平均血圧および脈圧)の脳卒中発症予測能

    井上隆輔, 大久保孝義, 菊谷昌浩, 浅山敬, 目時弘仁, 小原拓, 橋本潤一郎, 戸恒和人, 星晴久, 今井潤

    第28回日本高血圧学会総会 2005/09/15

  11. Prediction of stroke by four blood pressure indexes determined by 24-hour ambulatory blood pressure monitoring in a general population: the Ohasama study International-presentation

    Inoue R, Ohkubo T, Kikuya M, Metoki H, Asayama K, Obara T, Hoshi H, Hashimoto J, Totsune K, Satoh H, Kondo Y, Imai Y

    Fifteenth European Meeting on Hypertension 2005/06/17

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Research Projects 3

  1. Epidemiology of Japanese newborns' blood pressure

    Inoue Ryusuke

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2013/04/01 - 2016/03/31

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    Currently, normative means and ranges of blood pressure (BP) in Japanese newborns are not available. The objective of the present study was to estimate BP and their distribution among 4212 Japanese newborns. Similarly, we examined factors affecting BP among 2628 newborns. In addition, we estimated mean and range of arm-calf difference of BP among 3188 newborns. Averrage SBP and DBP among 4212 newborns were 70.2/43.9mmHg and they were normally distributed. The factors affecting newborn BP were birthweight, mode of delivery, and consiousness at BP measurement. Averrage arm BP and calf BP were 70.4/44.2mmHg and 69.8/43.6mmHg, respectively. Arm BP was higher than calf BP and the difference was significant. Newborns whose arm BP was lower than calf BP tended to be immature, suggesting that arm-calf difference of BP reflects maturation of newborns and small or negative arm-calf difference of BP may be associated with anoxia or ischemia.

  2. Development of method for urine sample collection in infant

    KURIYAMA Shinichi, METOKI Hirohito, INOUE Ryusuke

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2011 - 2012

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    Finally, 150 infants (76 boys; breastfeeding, 79 infants; mean age, 6.3+/-2.8 months;mean height, 68.0+/-8.8 cm; mean weight, 8.0+/-2.4 kg; gestational age, 39.5+/-1.9 weeks)participated in this study. Of those, we could collect urine sample from 70 infants. Mean day and time for collection of their urine sample was 5 days and 10.3 minutes, respectively. Characteristics of infants were not different between infants who could get urine sample and those who could not. We found that about a half of infants could collect their urine sample using a procedure which we proposed.

  3. Cardiovascular risk of exposure to secondhand smoke: longitudinal investigation with prospective cohort

    INOUE Ryusuke

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2010 - 2012

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    Home systolic blood pressure of nonsmoking women exposed to environmental tobacco smoke was significantly higher than that of women not exposed. Also, the risk of development of home hypertension among nonsmoking women with normal home blood pressure living with current smokers was significantly higher than that of those living with nonsmokers. Moreover, the risk of development of stroke among nonsmoking women with normal home blood pressure living with current smokers was significantly higher than that of those living with nonsmokers. It is important to prevent passive smoke at home.