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Toshiyuki Hayase

Section

Frontier Research Institute for Interdisciplinary Sciences

Job title

President-Appointed Extraordinary Professor

Degree

工学博士（名古屋大学）

researchmap

https://researchmap.jp/read0168553

J-GLOBAL ID

200901092147890664

Research History 6

2018/04 - Present

Tohoku University　Frontier Research Institute for Interdisciplinary Sciences　Director
2000/04 - 2021/03

Tohoku University　Institute of Fluid Science　Professor
2008/04 - 2014/03

Tohoku University　Institute of Fluid Science　Director
2006/04 - 2008/03

Tohoku University　Institute of Fluid Science Transdisciplinary Fluid Integration Research Center　Director
1990/10 - 2000/03

Tohoku University　Institute of Fluid Science　Associate professor
1980/03 - 1990/09

Nagoya University　School of Engineering　Research associate

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Education 2

Nagoya University　Graduate School, Division of Engineering　Mechanical Engineering

- 1980/03/25
Nagoya University　Faculty of Engineering　Mechanical Engineering

- 1978/03/25

Committee Memberships 14

日本機械学会　フェロー

2007/03 - Present
Japan Fluid Power System Association　理事

2016/05 - 2018/04
日本フルードパワーシステム学会　理事

2016/05 - 2018/04
統計数理研究所　外部評価委員

2013/04 - 2014/03
日本機械学会バイオエンジニアリング部門　運営委員

2012/04 - 2014/03
九州大学応用力学研究所運営協議会　委員

2008/04 - 2014/03
一般財団法人機器研究会　理事長

2008/04 - 2014/03
Japan Fluid Power System Association　理事

2008/05 - 2010/04
日本フルードパワーシステム学会　理事

2008/05 - 2010/04
計測自動制御学会東北支部　評議員

2009/01 - 2009/12
日本機械学会　評議員

2007/03 - 2009/02
計測自動制御学会東北支部　支部長

2006/01 - 2008/01
Japan Fluid Power System Association　理事

2003/05 - 2006/04
日本フルードパワーシステム学会　理事

2003/05 - 2006/04

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Professional Memberships 3

Japan Fluid Power System Association
計測自動制御学会
日本機械学会

Research Interests 4

Microcirculation
Ultrasonography
Measurement Integrated Simulation
Bioengineering

Research Areas 4

Manufacturing technology (mechanical, electrical/electronic, chemical engineering) / Fluid engineering / Flow Field Control
Informatics / Information theory / Fluid Intormatics
Life sciences / Biomaterials / Bioengineering
Life sciences / Biomedical engineering / Bioengineering

Awards 13

第25回功績賞

2021/06　日本機械学会バイオエンジニアリング部門
部門賞

2017/10　日本機械学会流体工学部門
Fluids Science Research Award

2016/10/11　一般財団法人機器研究会　流体科学における計測と数値解析の融合手法の開発とその応用
平成28 年度科学技術分野の文部科学大臣表彰（科学技術賞研究部門）

2016/04/20　文部科学省　流体計測と数値流体解析の融合手法とその応用に関する研究
日本機械学会バイオエンジニアリング部門第22回業績賞

2014/01/11　日本機械学会バイオエンジニアリング部門
日本機械学会流体工学部門フロンティア表彰

2007/11/17　日本機械学会流体工学部門
日本機械学会論文賞

2007/04/06　日本機械学会
(財)油空圧機器技術振興財団学術論文賞

1999/04/01　(財)油空圧機器技術振興財団
一般社団法人画像電子学会最優秀論文賞

2016/06/18　一般社団法人画像電子学会　2 次元非定常流動場の位相べースビジュアルデータマイニング
2015 JBSE Graphics of the year award

2016/03/31　Journal of Biomechanical Science and Engineering　Investigation of characteristic hemodynamic parameters indicating thinning and thickening sites of cerebral aneurysms
第４１回流体力学講演会／航空宇宙数値シミュレーション技術シンポジウム２００９最優秀賞流体力学部門

2009/09/30　航空宇宙学会　計測融合シミュレーションの誤差ダイナミクスに対する固有値解析
第２２回数値流体力学シンポジウムベストCFDグラフィックス・アワード最優秀賞

2008/12/18　流体力学会
第１２回計算工学講演会グラフィックスアワード優秀賞

2007/05/22　日本計算工学会

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Papers 513

Tracking of Blood Vessels Motion from 4D-flow MRI Data

Mocia Agbalessi, Alain Lalande, Olivier Bouchot, Toshiyuki Hayase, Jean Joseph Christophe, Miguel Angel Fernández, Damiano Lombardi

Cardiovascular Engineering and Technology　14　(4)　577-604　2023/08

DOI： 10.1007/s13239-023-00677-z 　

ISSN： 1869-408X

eISSN： 1869-4098
Development of Ultrasound Phantom Made of Transparent Material: Feasibility of Optical Particle Image Velocimetry International-journal Peer-reviewed

Muhammad Shiddiq Sayyid Hashuro, Simon Tupin, Narendra Kurnia Putra, Kotaro Daibo, Kosuke Inoue, Takuro Ishii, Hiroyuki Kosukegawa, Kenichi Funamoto, Toshiyuki Hayase, Makoto Ohta

Ultrasound in Medicine and Biology　49　(6)　1385-1394　2023/06

DOI： 10.1016/j.ultrasmedbio.2022.12.020 　

ISSN： 0301-5629

eISSN： 1879-291X
Numerical analysis of hemodynamic changes and blood stagnation in the left ventricle by internal structures and torsional motion Peer-reviewed

Suguru Miyauchi, Koichi Hosoi, Shingo Tsuda, Toshiyuki Hayase, Kenichi Funamoto

AIP Advances　13　(4)　045105　2023/04/01

DOI： 10.1063/5.0143833 　
Energy transfer in turbulent flows behind two side-by-side square cylinders International-journal International-coauthorship Peer-reviewed

Y. Zhou, K. Nagata, Y. Sakai, T. Watanabe, Y. Ito, T. Hayase

Journal of Fluid Mechanics　903　A4　2020/09/01

DOI： 10.1017/jfm.2020.611 　
Real-Time Estimation of Molten Steel Flow in Continuous Casting Mold Peer-reviewed

Yoshinari Hashimoto, Akitoshi Matsui, Toshiyuki Hayase, Manabu Kano

Metallurgical and Materials Transactions B: Process Metallurgy and Materials Processing Science　51　(2)　581-588　2020/04

DOI： 10.1007/s11663-020-01775-2 　

ISSN： 1073-5615
Blood pressure estimation based on pulse rate variation in a certain period Peer-reviewed

Toshiyuki Hayase

Scientific Reports　10　(1)　2020/01/29
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s41598-020-58367-y 　

eISSN： 2045-2322
Application of spectral proper orthogonal decomposition to velocity and passive scalar fields in a swirling coaxial jet Peer-reviewed

Pravin Ananta Kadu, Yasuhiko Sakai, Yasumasa Ito, Koji Iwano, Masatoshi Sugino, Takahiro Katagiri, Toshiyuki Hayase, Koji Nagata

Physics of Fluids　32　(1)　2020/01/01

DOI： 10.1063/1.5131627 　

ISSN： 1070-6631

eISSN： 1089-7666
Influence on Measurement Signal by Pressure and Viscosity Changes of Fluid and Installation Condition of FBG Sensor Using Blood Flow Simulation Model Peer-reviewed

Shouhei Koyama, Toshiyuki Hayase, Suguru Miyauchi, Atsushi Shirai, Shun Chino, Yuki Haseda, Hiroaki Ishizawa

IEEE Sensors Journal　19　(24)　11946-11954　2019/12/15

DOI： 10.1109/JSEN.2019.2938243 　

ISSN： 1530-437X

eISSN： 1558-1748
Three-DimensionalNumerical Analysis foran Erythrocyte Behaviornear a Wall in a Fluidunder an InclinedCentrifugal Force: FiniteElement Analysis of anErythrocyte Membrane

Suguru Miyauchi, Toshiyuki Hayase, Arash Alizad Banaei, Jean-Christophe Loiseau, Luca Brandt

Proceedings of 16th International Conference on Flow Dynamics (ICFD2019)　2019/11
Fundamental study ofThree-DimensionalUltrasonic-Measurement-Integrated Blood FlowAnalysis System :Verification of 3D-UMISimulation Algorithmwith Flow Phantom Experiment

Hirose Kudo, Suguru Miyauchi, Toshiyuki Hayase, Kosuke Inoue

Proceedings of 16th International Conference on Flow Dynamics (ICFD2019)　2019/11
Development of Wearable Device for Blood Pressure Estimation Based onPulse Rate Measurement: Fundamental Study of Estimation Algorithm

Soshi Kuroe, Toshiyuki Hayase, Suguru Miyauchi, Daisuke Ito, Shunkei Pak, Osamu Iwamoto

Proceedings of 16th International Conference on Flow Dynamics (ICFD2019)　2019/11
Viscosity estimation of a suspension with rigid spheres in circular microchannels using particle tracking velocimetry Peer-reviewed

Misa Kawaguchi, Tomohiro Fukui, Kenichi Funamoto, Miho Tanaka, Mitsuru Tanaka, Shigeru Murata, Suguru Miyauchi, Toshiyuki Hayase

Micromachines　10　(10)　2019/10/01

DOI： 10.3390/mi10100675 　

eISSN： 2072-666X
Numerical analysis of the blood flow in the left ventricle with internal structures: Effect of trabeculae carneae models and atrial fibrillation Peer-reviewed

Suguru Miyauchi, Tomomi Yamada, Koichi Hosoi, Toshiyuki Hayase, Kenichi Funamoto

AIP ADVANCES　9　(10)　2019/10

DOI： 10.1063/1.5124730 　

eISSN： 2158-3226
Dissipation scaling in the transition region of turbulent mixing layer Peer-reviewed

K. Takamure, Y. Sakai, Y. Ito, K. Iwano, T. Hayase

International Journal of Heat and Fluid Flow　75　77-85　2019/02

DOI： 10.1016/j.ijheatfluidflow.2018.11.012 　

ISSN： 0142-727X
Elucidation of Mechanisms of FBG Vital Sensing by Ultrasonic-Measurement-Integrated Simulation Invited

MIYAUCHI SUGURU, HAYASE TOSHIYUKI

Sen'i Gakkaishi　75　(12)　P-628-P-632　2019

DOI： 10.2115/fiber.75.P-628 　

ISSN： 0037-9875
Experimental study on the effects of radial dispersion of spherical particles on the suspension rheology Peer-reviewed

Misa Kawaguchi, Tomohiro Fukui, Kenichi Funamoto, Suguru Miyauchi, Toshiyuki Hayase

ASME-JSME-KSME 2019 8th Joint Fluids Engineering Conference, AJKFluids 2019　5　2019

DOI： 10.1115/AJKFluids2019-5322 　
Fluid Dynamics and Energy/scalar Transport in Coexisting Flows of Turbulence and Non-turbulence Peer-reviewed

Y. Sakai, Y. Ito, K. Iwano, T. Hayase, Z. Yi, S. Nagaya, J. Yu

Proceedings of 18th International Symposium on Advanced Fluid Information　188-189　2018/11
Numerical and experimental studies on non-Newtonian rheology of a suspension Peer-reviewed

M. Kawaguchi, T. Fukui, K. Funamoto, S. Miyauchi, T. Hayase

Proceedings of 18th International Symposium on Advanced Fluid Information　134-135　2018/11
Influence of Swirl on Coaxial Jets Peer-reviewed

P. Kadu, Y. Sakai, Y. Ito, K. Iwano, M. Sugino, T. Katagiri, T. Hayase

Proceedings of the Fifteenth International Conference on Flow Dynamics (ICFD2018)　776-777　2018/11
Fundamental Evaluation of a Pulse Wave Measurement System Mimicking Pulse Diagnosis Using a Wrist Pulsatile Blood Flow Model Peer-reviewed

Tsuboi, T, Shirai, A, Miyauchi, S, Hayase, T

Proceedings of the Fifteenth International Conference on Flow Dynamics (ICFD2018)　714-715　2018/11
Finite Element Analysis for Flows in a Tumor Capillary Considering a Leakage to Interstitium Peer-reviewed

Takeda, T, Miyauchi, S, Hayase, T

Proceedings of the Fifteenth International Conference on Flow Dynamics (ICFD2018)　632-633　2018/11
Elucidation of Mechanism of Fiber Bragg Grating Vital Sensing by Ultrasonic-Measurement-Integrated Simulation: Flow Analysis in Ultrasound Flow Phantom Peer-reviewed

Miyauchi, S, Hayase, T, Inoue, K, Ogasawara, T, Tsuboi, T, Shirai, A, Chino, S, Koyama, S, Ishizawa, H

Proceedings of the Fifteenth International Conference on Flow Dynamics (ICFD2018)　602-603　2018/11
Study of Hemodynamic Parameters to Identify Thickening and Thinning Parts of Cerebral Aneurysm Wall: Evaluation of Confined Relative Residence Time based on Analysis of Transport Equation Peer-reviewed

Aoki, K, Miyauchi, S, Hayase, T, Sugiyama, S, Tominaga, T

Proceedings of the Fifteenth International Conference on Flow Dynamics (ICFD2018)　620-621　2018/11
Development of new human thermal model based on blood flow rate measurements under different temperature conditions Peer-reviewed

T Goto, D Terayama, H Sakamoto, T Hayase, Y Saijo, R Sugawara, Z Niu

15th Conference of the International Society of Indoor Air Quality and Climate (Indoor Air 2018)　2018/07
Amplification and attenuation of shock wave strength caused by homogeneous isotropic turbulence Peer-reviewed

K. Tanaka, T. Watanabe, K. Nagata, A. Sasoh, Y. Sakai, T. Hayase

Physics of Fluids　30　(3)　2018/03/01

DOI： 10.1063/1.5019867 　

ISSN： 1070-6631

eISSN： 1089-7666
Momentum transport process in the quasi self-similar region of free shear mixing layer Peer-reviewed

K. Takamure, Y. Ito, Y. Sakai, K. Iwano, T. Hayase

Physics of Fluids　30　(1)　2018/01/01

DOI： 10.1063/1.5004500 　

ISSN： 1070-6631

eISSN： 1089-7666
Numerical analysis of the effect of trabeculae carneae models on blood flow in a left ventricle model constructed from magnetic resonance images Peer-reviewed

Tomomi Yamada, Toshiyuki Hayase, Suguru Miyauchi, Kenichi Funamoto

Journal of Biomechanical Science and Engineering　13　(2)　2018

DOI： 10.1299/jbse.17-00597 　

ISSN： 1880-9863
Detection and Correction of Aliasing and Reverse Flow in Two-Dimensional Ultrasonic-Measurement-Integrated Blood Flow Analysis

Daisuke Harada, Toshiyuki Hayase, Suguru Miyauchi, Kosuke Inoue

Proceedings of the 14th International Conference on Flow Dynamics (ICFD2017)　2017/11
Study of Hemodynamic Parameters to Identify Thickening and Thinning Parts of Cerebral Aneurysm Wall: Proposition of a New Parameter Taking Account of Second Derivative of Near-wall Velocity to Identify the Thickening Part

Kazumasa Aoki, Daichi Suzuki, Toshiyuki Hayase, Suguru Miyauchi, Shin-ichiro. Sugiyama, Teiji Tominaga

Proceedings of the 14th International Conference on Flow Dynamics (ICFD2017)　2017/11
Patient-Specific Analysis of Flow Patterns and Stress Areas Associated with Tricuspid and Bicuspid Valve

Clément Acquitter, Masato Ogitsu, Stéphanie Bricq, Jean-Joseph. Christophe, Olivier Bouchot, Suguru Miyauchi, Toshiyuki Hayase, Alain Lalande

Proceedings of the 14th International Conference on Flow Dynamics (ICFD2017)　2017/11
Fundamental Study of MR-Measurement-Integrated Simulation of Heart-Aorta System: Inflow Estimation Using 4D Flow MR data

Masato Ogitsu, Toshiyuki Hayase, Suguru Miyauchi, Kosuke Inoue, Alain Lalande, Clément Acquitter, Jean-Joseph Christophe

Proceedings of the 14th International Conference on Flow Dynamics (ICFD2017)　2017/11
Estimation of viscosity profiles of semidilute suspensions by computational and experimental studies

Misa Kawaguchi, Tomohiro Fukui, Kenichi Funamoto, Toshiyuki Hayase

Proceedings of the 17th International Symposium on Advanced Fluid Information (AFI-2017)　78-79　2017/11/01
Universality of periodic oscillation induced in side branch of a T-junction in numerical simulation Peer-reviewed

Ryuhei Yamaguchi, Gaku Tanaka, Tadashi Nakagawa, Atsushi Shirai, Hao Liu, Toshiyuki Hayase

Journal of Flow Control, Measurement & Visualization　5　(4)　73-85　2017/10
Photoplethysmography and ultrasonic-measurement-integrated simulation to clarify the relation between two-dimensional unsteady blood flow field and forward and backward waves in a carotid artery Peer-reviewed

Shusaku Sone, Toshiyuki Hayase, Kenichi Funamoto, Atsushi Shirai

Medical & Biological Engineering & Computing　55　(5)　719-731　2017/05
Publisher: Springer Science and Business Media {LLC}
DOI： 10.1007/s11517-016-1543-4 　

ISSN： 0140-0118

eISSN： 1741-0444
Patient-Specific Study Of Stress Area Of The Pathological Aorta. A Combined 4D Flow MRI - Computational Fluid Dynamics Analysis

Acquitter Clément, Hayase Toshiyuki, Lalande Alain

Transactions of Japanese Society for Medical and Biological Engineering　55　(5)　413-413　2017
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.55Annual.413 　

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A methodology allowing a combined analysis of pathological human thoracic aorta (TA) using both 4D flow MRI and computational fluid dynamics (CFD) is presented. MR images from patient with aneurysm have been acquired with a 4D Flow MRI sequence. The segmentation of the aorta has been performed on the PCMRA image. A volumetric tetrahedral mesh with one inlet and four outlets was generated. In CFD simulations, blood density and viscosity were assumed to be 1060kg/m3 and 4.10-3 Pa.s, respectively. MRI velocity measurements have been used as boundary conditions. CFD simulations have been compared to MRI measurements both qualitatively and quantitatively. A visual evaluation using streamlines and volumetric flow rates at the outlets show good agreements. Moreover, hemodynamics parameters such as WSS have been computed and allow for the evaluation of stress areas. A methodology for a combined analysis of TA taking advantage of both MRI and CFD was proposed.
Effects of upstream bifurcation and bend on the blood flow in a cerebral aneurysm Peer-reviewed

Daichi Suzuki, Kenichi Funamoto, Shin-ichiro Sugiyama, Toshiyuki Hayase, Suguru Miyauchi, Teiji Tominaga

Journal of Biomechanical Science and Engineering　12　(4)　17-00189-1-17-00189-11　2017
Publisher: Japan Society of Mechanical Engineers
DOI： 10.1299/jbse.17-00189 　

ISSN： 1880-9863
Two-dimensional numerical simulation of the behavior of a circular capsule subject to an inclined centrifugal force near a plate in a fluid Peer-reviewed

Suguru Miyauchi, Toshiyuki Hayase, Arash Alizad Banaei, Jean-Christophe Loiseau, Luca Brandt, Fredrik Lundell

Journal of Fluid Science and Technology　12　(2)　2017

DOI： 10.1299/jfst.2017jfst0015 　

ISSN： 1880-5558
Deformation of stenotic blood vessel model made from Poly (Vinyl Alcohol) Hydrogel by hydrostatic pressure Peer-reviewed

Yasutomo Shimizu, Lei Liu, Hiroyuki Kosukegawa, Kenichi Funamoto, Toshiyuki Hayase, Toshio Nakayama, Makoto Ohta

PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, 2016, VOL. 3　2016　2017
Numerical analysis for elucidation of mechanical interaction between an erythrocyte moving in medium subject to inclined centrifugal force and endothelial cells on a plate Peer-reviewed

Akira Yatsuyanagi, Toshikyuki Hayase, Suguru Miyauchi, Kenichi Funamoto, Kosuke Inoue, Atsushi Shirai, Luca Brandt

Journal of Fluid Science and Technology　11　(4)　2016/12

DOI： 10.1299/jfst.2016jfst0029 　
Measurement of blood flow rates under three different temperatures, and development of a new human thermal model

Daiki Terayama, Hiroto Sakamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomonobu Goto

The 5th International Conference on Human-Environment System　2016/10/29
Preliminary study for fluid dynamic effects of upstream bifurcation and bend on blood flow simulation in cerebral aneurysm

Daichi Suzuki, Kenichi Funamoto, Shin-ichiro Sugiyama, Toshiyuki Hayase, Suguru Miyauchi, Teiji Tominaga

Proceedings of the 13th International Conference on Flow Dynamics (ICFD2016)　264-265　2016/10/11
Analysis of an autonomic nervous system of mouse fetus with congenital heart defect

Kiyoe Funamoto, Rika Sugibayashi, Kenichi Funamoto, Kana Nakanishi, Takuya Ito, Motoyoshi Kawataki, Toshiyuki Hayase, Yoshitaka Kimura

Proceedings of the 16th International Symposium on Advanced Fluid Information (AFI-2016)　92-93　2016/10/11
Computational and experimental studies on the blood cells behavior in microcirculation

Tomohiro Fukui, Misa Kawaguchi, Atsuhide Kitagawa, Kenichi Funamoto, Toshiyuki Hayase

Proceedings of the 16th International Symposium on Advanced Fluid Information (AFI-2016)　82-83　2016/10/11
Computational investigation toward selective collection of water particles containing odorous molecules by electrostatic spraying Peer-reviewed

Jin Muraoka, Kenichi Funamoto, Mariko Seno, Satoshi Arimoto, Ken Shimono, Satoshi Suzuki, Yoshio Mitsutake, Tetsuya Maekawa, Toshihiko Yoshioka, Toshiyuki Hayase

JOURNAL OF ELECTROSTATICS　83　35-41　2016/10

DOI： 10.1016/j.elstat.2016.07.004 　

ISSN： 0304-3886

eISSN： 1873-5738
Grid Convergence Property of Three-Dimensional Measurement-Integrated Simulation for Unsteady Flow Behind a Square Cylinder with Karman Vortex Street Peer-reviewed

Takayuki Yamagata, Toshiyuki Hayase

Journal of Flow Control, Measurement & Visualization　4　125-142　2016/09/13
Effects of inflow velocity profile on two-dimensional hemodynamic analysis by ordinary and ultrasonic-measurement-integrated simulations Peer-reviewed

Takaumi Kato, Shusaku Sone, Kenichi Funamoto, Toshiyuki Hayase, Hiroko Kadowaki, Nobuyuki Taniguchi

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING　54　(9)　1331-1339　2016/09

DOI： 10.1007/s11517-015-1376-6 　

ISSN： 0140-0118

eISSN： 1741-0444
Fluid Vibration Induced by High-Shear-Rate Flow in a T-Junction Peer-reviewed

Gaku Tanaka, Ryuhei Yamaguchi, Hao Liu, Toshiyuki Hayase

JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME　138　(8)　2016/08

DOI： 10.1115/1.4032935 　

ISSN： 0098-2202

eISSN： 1528-901X
水棲微小生物の繊毛遊泳脚による推進機構に関する数値解析(単一遊泳脚モデルの繊毛間隔が推進力に与える影響) Peer-reviewed

A. Shirai, K. Inoue, T. Hayase, S. Sudo

日本機械学会論文集　82　(840)　16-00099-16-00099　2016/08
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/transjsme.16-00099 　

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The goal of this study is elucidation of propulsion mechanism of small creatures by ciliated swimming legs. For this purpose, a ciliated pereiopod of an opossum shrimp was introduced and it was modeled with a straight cylindrical stem with 10 much narrower cylindrical poles perpendicularly projecting on the stem. Flow drag acting on the pereiopod in a steady flow, which corresponds to the thrust force by paddling of the pereiopod, was computed with a variety of clearance between each adjacent pair of cilia d and the flow velocity U. It was found that the drag increased with the increase in d to be saturated with a certain value in the range of d ≥ 0.04 mm where influence of boundary layers of adjacent cilia is negligible, and the drag agreed well with that estimated from drag of a two-dimensional cylinder. This result suggests that the opossum shrimp is propelled with the drag-based swimming and the ciliated pereiopods supply greater thrust force than tabular pereiopods with the same projection area. It was also found that the drag decreased in the range of d > 0.07 mm in which some cilia come into the boundary layer of body of the shrimp. It was optically observed that distance between adjacent cilia is around 0.07 mm on the stem and cilia near the root of the pereiopod are shorter than those near the tip. The present results suggest that the ciliated pereiopod is well designed to efficiently generate the thrust force within a limited length and mass by preventing influence of the boundary layers.
Implicit large eddy simulation of a scalar mixing layer in fractal grid turbulence Peer-reviewed

Tomoaki Watanabe, Yasuhiko Sakai, Kouji Nagata, Yasumasa Ito, Toshiyuki Hayase

PHYSICA SCRIPTA　91　(7)　2016/07

DOI： 10.1088/0031-8949/91/7/074007 　

ISSN： 0031-8949

eISSN： 1402-4896
Reduced Uterine Perfusion Pressure (RUPP) Model of Preeclampsia in Mice Peer-reviewed

Tomofumi Fushima, Akiyo Sekimoto, Takahiro Minato, Takuya Ito, Yuji Oe, Kiyomi Kisu, Emiko Sato, Kenichi Funamoto, Toshiyuki Hayase, Yoshitaka Kimura, Sadayoshi Ito, Hiroshi Sato, Nobuyuki Takahashi

PLOS ONE　11　(5)　e0155426　2016/05

DOI： 10.1371/journal.pone.0155426 　

ISSN： 1932-6203
Spatial evolution of the helical behavior and the 2/3 power-law in single-square-grid-generated turbulence Peer-reviewed

Yi Zhou, Kouji Nagata, Yasuhiko Sakai, Yasumasa Ito, Toshiyuki Hayase

FLUID DYNAMICS RESEARCH　48　(2)　2016/04

DOI： 10.1088/0169-5983/48/2/021404 　

ISSN： 0169-5983

eISSN： 1873-7005
Lagrangian properties of the entrainment across turbulent/non-turbulent interface layers Peer-reviewed

Tomoaki Watanabe, Carlos B. da Silva, Yasuhiko Sakai, Koji Nagata, Toshiyuki Hayase

PHYSICS OF FLUIDS　28　(3)　2016/03

DOI： 10.1063/1.4942959 　

ISSN： 1070-6631

eISSN： 1089-7666
Enstrophy production and dissipation in developing grid-generated turbulence Peer-reviewed

Yi Zhou, Koji Nagata, Yasuhiko Sakai, Yasumasa Ito, Toshiyuki Hayase

PHYSICS OF FLUIDS　28　(2)　2016/02

DOI： 10.1063/1.4941855 　

ISSN： 1070-6631

eISSN： 1089-7666
Study of Estimation Method for Unsteady Inflow Velocity in Two-Dimensional Ultrasonic-Measurement-Integrated Blood Flow Simulation Peer-reviewed

Hiroko Kadowaki, Toshiyuki Hayase, Kenichi Funamoto, Nobuyuki Taniguchi

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING　63　(2)　403-414　2016/02

DOI： 10.1109/TBME.2015.2461559 　

ISSN： 0018-9294

eISSN： 1558-2531
Three-Dimensional Numerical Analysis for an Erythrocyte Behavior near a wall in a fluid under an inclined centrifugal force

Suguru Miyauchi, Toshiyuki Hayase, Arash Alizad Banaei, Jean-Christophe Loiseau, Luca Brandt

Proceedings of the 16th International Symposium on Advanced Fluid Information　2016
Reproduction of Turbulent flow field behind a square cylinder by hybrid wind tunnel

Kohei Kawamoto, Toshiyuki Hayase, Suguru Miyauchi, Kosuke Inoue, Shervin Bagheri, Fredrik Lundell

Proceedings of the 13th International Conference on Flow Dynamics (ICFD2016)　2016　(51)　43-44　2016
Publisher: The Japan Society of Mechanical Engineers
Two-Dimensional ultrasonic-measurement-integrated blood flow analysis considering deformation of blood vessel by pulsation: extraction of unsteady vessel shape from B-mode images

Daisuke Harada, Toshiyuki Hayase, Suguru Miyauchi, Kosuke Inoue, Hiroko Kadowaki, Tadashi Shimazaki, Takao Jibiki, Koji Miyama

Proceedings of the 13th International Conference on Flow Dynamics (ICFD2016)　2016　(51)　183-184　2016
Publisher: The Japan Society of Mechanical Engineers
Determination of fluid mechanical effects caused by near wall blood flow field on endothelial cell damage: effect of shear stress on cell peeling of cultured endothelial cells

Miria Suzuki, Toshiyuki Hayase, Suguru Miyauchi, Kosuke Inoue

Proceedings of the 13th International Conference on Flow Dynamics (ICFD2016)　2016　(51)　185-186　2016
Publisher: The Japan Society of Mechanical Engineers
Fundamental Numerical analysis of the effect of inner structure of left ventricle on the blood flow field

Tomomi Yamada, Toshiyuki Hayase, Suguru Miyauchi

Proceedings of the 13th International Conference on Flow Dynamics (ICFD2016)　2016
Fundamental Study of MR-Measurement-Integral Simulation of Hear-Aorta System: Numerical Simulation of Blood Flow in an Aorta

Masato Ogitsu, Toshiyuki Hayase, Suguru Miyauchi, Kosuke Inoue, Alain Lalande, Clement Aquitter, Jean-Joseph Christophe

Proceedings of the 13th International Conference on Flow Dynamics (ICFD2016)　2016
Study of Permeability Changes of Endothelial Cell Monolayer Exposed to Hypoxia

K. Matsubara, K. Funamoto, I.K. Zervantonakis, K. Funamoto, T. Ito, Y. Kimura, T. Hayase, R.D. Kamm

Proceedings of the 12th International Conference on Flow Dynamics (ICFD2015)　362-363　2015/10/29
Determination of Optimum Feedback Gain of Two-Dimensional Ultrasonic-Measurement-Integrated Blood Flow Analysis System

H. Kadowaki, T. Hayase, K. Funamoto, S. Miyauchi, K. Inoue, T. Shimazaki, T. Jibiki, K. Miyama

Proceedings of the 12th International Conference on Flow Dynamics (ICFD2015)　460-461　2015/10/29
Fundamental Study of Interaction between Erythrocyte and Endothelial Cell under Inclined Centrifugal Force (Physical Explanation of Interaction Model)

A. Yatsuyagagi, T. Hayase, S. Miyauchi, K. Funamoto, K. Inoue, A. Shirai, L. Brandt

Proceedings of 12th International Conference on Flow Dynamics (ICFD2015)　320-321　2015/10/28
Numerical Analysis of Ultrasound Scattering Property of Medium Mimicking Blood (Influence of Ultrasound Frequency)

Y. Chiba, T. Hayase, S. Miyauchi, K. Funamoto

Proceedings of the 12th International Conference on Flow Dynamics (ICFD2015)　308-309　2015/10/28
Cardiac Evaluation of Fetal Mice by ECG and Ultrasound

R. Sugibayashi, T. Ito, K. Funamoto, T. Hayase, Y. Kimura

Proceedings of the 15th International Symposium on Advanced Fluid Information (AFI-2015)　184-185　2015/10/28
Investigation of Inlet Position in Hemodynamic Analysis of a Cerebral Aneurysm

D. Suzuki, K. Funamoto, S. Sugiyama, T. Hayase, S. Miyauchi, T. Tominaga

Proceedings of the 12th International Conference on Flow Dynamics (ICFD2015)　304-305　2015/10/27
Measurement-Integrated Analysis Methodology for Complex Flow Systems: Collaborative Research Overview

Toshiyuki Hayase, Suguru Miyauchi, Kosuke Inoue, Luca Brandt, Shervin Bagheri, Fredrik Lundell

Proceedings of 15th International Symposium on Advanced Fluid Information　2015/10
Zero-dimensional simulation of internal and external blood flows of a human body

Yuya Saito, Toshiyuki Hayase, Suguru Miyauchi

Proceedings of Twelfth International Conference on Flow Dynamics (ICFD2015)　2016　(51)　139-140　2015/10
Publisher: The Japan Society of Mechanical Engineers
LES-Lagrangian particle method for turbulent reactive flows based on the approximate deconvolution model and mixing model Peer-reviewed

Tomoaki Watanabe, Yasuhiko Sakai, Kouji Nagata, Yasumasa Ito, Toshiyuki Hayase

JOURNAL OF COMPUTATIONAL PHYSICS　294　127-148　2015/08

DOI： 10.1016/j.jcp.2015.03.038 　

ISSN： 0021-9991

eISSN： 1090-2716
Turbulent mixing of passive scalar near turbulent and non-turbulent interface in mixing layers Peer-reviewed

T. Watanabe, Y. Sakai, K. Nagata, Y. Ito, T. Hayase

PHYSICS OF FLUIDS　27　(8)　1-19　2015/08

DOI： 10.1063/1.4928199 　

ISSN： 1070-6631

eISSN： 1089-7666
Effect of Speckle Noise in Ultrasonic Measurement on Two-Dimensional Ultrasonic-Measurement-Integrated Blood Flow Analysis Peer-reviewed

H. Kadowaki, T. Hayase, K. Funamoto, S. Miyauchi, K. Inoue, T. Shimazaki, T. Jibiki, K. Miyama

Proceedings of the World Congress on Electrical Engineering and Computer Systems and Science (EECSS 2015)　323-1-323-8　2015/07/15
On the evolution of the invariants of the velocity gradient tensor in single-square-grid-generated turbulence Peer-reviewed

Yi Zhou, Koji Nagata, Yasuhiko Sakai, Yasumasa Ito, Toshiyuki Hayase

PHYSICS OF FLUIDS　27　(7)　1-24　2015/07

DOI： 10.1063/1.4926472 　

ISSN： 1070-6631

eISSN： 1089-7666
Measurements of Blood Flow and Blood Pressure under Different Indoor Temperature and Body Postural Conditions, and Development of a New Human Simulation Model Peer-reviewed

H. Sakamoto, Y. Chiba, T. Hayase, K. Funamoto, Y. Saijo, T. Goto

Healthy Buildings Europe 2015　437-1-437-8　2015/05/18
A Review of Measurement-Integrated Simulation of Complex Real Flows Invited Peer-reviewed

Hayase T

J Flow Control Meas Visualization　3　(2)　51-66　2015/04/03
Numerical analysis of hemodynamic changes in the left atrium due to atrial fibrillation Peer-reviewed

Ryo Koizumi, Kenichi Funamoto, Toshiyuki Hayase, Yusuke Kanke, Muneichi Shibata, Yasuyuki Shiraishi, Tomoyuki Yambe

JOURNAL OF BIOMECHANICS　48　(3)　472-478　2015/02

DOI： 10.1016/j.jbiomech.2014.12.025 　

ISSN： 0021-9290

eISSN： 1873-2380
Preface for the "Special issue on biomedical flow dynamics" Peer-reviewed

Toshiyuki Hayase, Takehiko Sato, Makoto Ohta

Journal of Biomechanical Science and Engineering　10　(1)　1-1　2015
Publisher: Japan Society of Mechanical Engineers
DOI： 10.1299/jbse.15preface01 　

ISSN： 1880-9863
Poly(vinyl alcohol) gel ultrasound phantom with durability and visibility of internal flow Peer-reviewed

Kenichi Funamoto, Osamu Yamashita, Toshiyuki Hayase

JOURNAL OF MEDICAL ULTRASONICS　42　(1)　17-23　2015/01

DOI： 10.1007/s10396-014-0560-x 　

ISSN： 1346-4523

eISSN： 1613-2254
Microscopic observation of glass bead movement in soft tissue-mimicking phantom under ultrasound PW mode scanning Peer-reviewed

Lei Liu, Kenichi Funamoto, Masayuki Tanabe, Toshiyuki Hayase

JOURNAL OF MEDICAL ULTRASONICS　42　(1)　59-63　2015/01

DOI： 10.1007/s10396-014-0565-5 　

ISSN： 1346-4523

eISSN： 1613-2254
Blood flow analysis in carotid artery bifurcation by two-dimensional ultrasonic-measurement-integrated simulation Peer-reviewed

Hiroko Kadowaki, Toshiyuki Hayase, Kenichi Funamoto, Shusaku Sone, Tadashi Shimazaki, Takao Jibiki, Koji Miyama

Journal of Biomechanical Science and Engineering　10　(1)　1-14　2015
Publisher: Japan Society of Mechanical Engineers
DOI： 10.1299/jbse.14-00266 　

ISSN： 1880-9863
Investigation of characteristic hemodynamic parameters indicating thinning and thickening sites of cerebral aneurysms Peer-reviewed

Daichi Suzuki, Kenichi Funamoto, Shinichiro Sugiyama, Toshio Nakayama, Toshiyuki Hayase, Teiji Tominaga

Journal of Biomechanical Science and Engineering　10　(1)　1-10　2015
Publisher: Japan Society of Mechanical Engineers
DOI： 10.1299/jbse.14-00265 　

ISSN： 1880-9863
Numerical Analysis for Elucidation of Nonlinear Frictional Characteristics of a Deformed Erythrocyte Moving on a Plate in Medium Subject to Inclined Centrifugal Force Peer-reviewed

Takashi Oshibe, Toshiyuki Hayase, Kenichi Funamoto, Atsushi Shirai

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME　136　(12)　121003　2014/12

DOI： 10.1115/1.4028723 　

ISSN： 0148-0731

eISSN： 1528-8951
Development and feasibility study of a two-dimensional ultrasonic-measurement-integrated blood flow analysis system for hemodynamics in carotid arteries Peer-reviewed

Takaumi Kato, Kenichi Funamoto, Toshiyuki Hayase, Shusaku Sone, Hiroko Kadowaki, Tadashi Shimazaki, Takao Jibiki, Koji Miyama, Lei Liu

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING　52　(11)　933-943　2014/11

DOI： 10.1007/s11517-014-1193-3 　

ISSN： 0140-0118

eISSN： 1741-0444
Vortex stretching and compression near the turbulent/non-turbulent interface in a planar jet Peer-reviewed

Tomoaki Watanabe, Yasuhiko Sakai, Kouji Nagata, Yasumasa Ito, Toshiyuki Hayase

JOURNAL OF FLUID MECHANICS　758　754-785　2014/11

DOI： 10.1017/jfm.2014.559 　

ISSN： 0022-1120

eISSN： 1469-7645
On the Motility and Locomotive Organs of Beach Flea

Seiichi Sudo, Atsushi Shirai, Toshiyuki Hayase, Takuya Amano

Proceedings of ISABME2014　2014/11

DOI： 10.5226/jabmech.4.37 　
Analysis of High Reynolds Number Flow behind a Square Cylinder by Hybrid Wind Tunnel (Improvement of Critical Gain of Instability for Pressure Feedback)

Jumpei Okutani, Toshiyuki Hayase, Kosuke Inoue, Shusaku Sone, Kenichi Funamoto

Proceedings of the Eleventh International Conference on Flow Dynamics (ICFD2014)　270-271　2014/10/10
Application of MR-Measurement-Integrated Hemodynamic Simulation to Cerebrovascular Diseases

S. Sugiyama, K. Funamoto, D. Suzuki, T. Hayase, T. Tominaga

Proceedings of the 14th International Symposium on Advanced Fluid Information (AFI-2014)　104-105　2014/10/09
Elucidation of Mechanisms of the Frictional Characteristics of Erythrocytes under Inclined Centrifugal Force

K. Funamoto, L. Brandt, A. Yatsuyanagi, K. Inoue, T. Hayase

Proceedings of the 14th International Symposium on Advanced Fluid Information (AFI-2014)　100-101　2014/10/09
Investigation on Advanced Medical Ultrasound Imaging Technology

M. Tanabe, H. Hashimoto, K. Funamoto, Y. Chiba, T. Hayase

Proceedings of the 14th International Symposium on Advanced Fluid Information (AFI-2014)　192-193　2014/10/09
Fundamental Study of Interaction between Erythrocyte and Endothelial Cell under Inclined Centrifugal Force (Reproduction of Friction Characteristics by Numerical Analysis Using Simple Interaction Model)

Akira Yatsuyanagi, Toshiyuki Hayase, Kenichi Funamoto, Kosuke Inoue, Atsushi Shirai

Proceedings of the Eleventh International Conference on Flow Dynamics (ICFD2014)　296-297　2014/10/08
Enstrophy and passive scalar transport near the turbulent/non-turbulent interface in a turbulent planar jet flow Peer-reviewed

T. Watanabe, Y. Sakai, K. Nagata, Y. Ito, T. Hayase

PHYSICS OF FLUIDS　26　(10)　2014/10

DOI： 10.1063/1.4898208 　

ISSN： 1070-6631

eISSN： 1089-7666
Reactive scalar field near the turbulent/non-turbulent interface in a planar jet with a second-order chemical reaction Peer-reviewed

T. Watanabe, Y. Sakai, K. Nagata, Y. Ito, T. Hayase

PHYSICS OF FLUIDS　26　(10)　2014/10

DOI： 10.1063/1.4900403 　

ISSN： 1070-6631

eISSN： 1089-7666
Wavelet analysis of coherent vorticity near the turbulent/non-turbulent interface in a turbulent planar jet Peer-reviewed

T. Watanabe, Y. Sakai, K. Nagata, Y. Ito, T. Hayase

PHYSICS OF FLUIDS　26　(9)　2014/09

DOI： 10.1063/1.4896298 　

ISSN： 1070-6631

eISSN： 1089-7666
Studies on the basic technology of “Sono-cytometry” Peer-reviewed

Yosuke Komatsu, Ryo Nagaoka, Kenichi Funamoto, Toshiyuki Hayase, Nobuo Masauzi, Hiroshi Kanai, Yoshifumi Saijo

Transactions of Japanese Society for Medical and Biological Engineering　52　351-O-352　2014/08/17
Publisher: Japan Soc. of Med. Electronics and Biol. Engineering
DOI： 10.11239/jsmbe.52.O-351 　

ISSN： 1347-443X 1881-4379
Simultaneous Analysis System for Blood Pressure and Flow Using Ultrasonic-Measurement-Integrated Simulation

Shusaku Sone, Toshiyuki Hayase, Kenichi Funamoto, Atsushi Shirai

Abstracts of the 7th World Congress of Biomechanics　F5　2014/07/11
Optimization of Strut Placement in Flow Diverter Stents for Four Different Aneurysm Configurations Peer-reviewed

Hitomi Anzai, Jean-Luc Falcone, Bastien Chopard, Toshiyuki Hayase, Makoto Ohta

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME　136　(6)　2014/06

DOI： 10.1115/1.4027411 　

ISSN： 0148-0731

eISSN： 1528-8951
Development of turbulence behind the single square grid Peer-reviewed

Yi Zhou, Kouji Nagata, Yasuhiko Sakai, Hiroki Suzuki, Yasumasa Ito, Osamu Terashima, Toshiyuki Hayase

PHYSICS OF FLUIDS　26　(4)　2014/04

DOI： 10.1063/1.4870167 　

ISSN： 1070-6631

eISSN： 1089-7666
Topologically-Based Visual Data Mining for 2D Unsteady Flow Fields Peer-reviewed

Takeshima Yuriko, Fujishiro Issei, Takahashi Shigeo, Hayase Toshiyuki

The Journal of the Institute of Image Electronics Engineers of Japan　43　(3)　357-366　2014
Publisher: The Institute of Image Electronics Engineers of Japan
DOI： 10.11371/iieej.43.357 　

ISSN： 0285-9831

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Vortices can be considered as one of the most fundamental features of a fluid, and play an indispensable role in the understanding of dynamics of underlying flows. However, it is difficult to capture time-varying, complex vortex structures consistently with traditional trial-and-error visualization methods because flow fields are changing drastically in unsteady fluid datasets. In this paper, we therefore propose a topologically-based approach to visual data mining of unsteady flow field datasets. Since it is well-known that the vortex centers are located at local minima in the 2D associated pressure field, we identify their locations by extracting critical points of the field, segmenting it into sub-regions each of vortices using topological information, and trace the vortices in the unsteady datasets. In addition, we propose a novel transfer function design which employs constant hue assignment and a stepwise brightness setting for timeseries datasets. The design of transfer function allows users to understand the global change in the flow fields from the hue value as well as the behavior of the vortices even if the flow fields are changing drastically. The feasibility of our approach is illustrated with an application to practical datasets for Karman vortex street, which are taken from measurement-integrated simulation of the Hybrid Wind Tunnel.
DNS of turbulent Schmidt number and eddy diffusivity for reactive concentrations Peer-reviewed

WATANABE Tomoaki, SAKAI Yasuhiko, NAGATA Kouji, TERASHIMA Osamu, ITO Yasumasa, HAYASE Toshiyuki

Transactions of the JSME (in Japanese)　80　(809)　FE0008-FE0008　2014
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/transjsme.2014fe0008 　

ISSN： 2187-9761

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The gradient diffusion hypothesis for turbulent mass fluxes of reactive scalar is investigated by using direct numerical simulations (DNS) of a planar jet with a second-order chemical reaction A+B→R. Reactants A and B are separately supplied in the jet and ambient fluids, respectively. DNS is performed at three different Damköhler numbers, i.e, Da=0.1, 1, and 10. Eddy diffusivity and turbulent Schmidt number of reactive species are calculated from the DNS results. The results show that the longitudinal (x-direction) eddy diffusivity of reactant A near the jet centerline is always positive, whereas the longitudinal eddy diffusivities of reactant B and product R can be negative near the jet centerline. Near the jet centerline, the lateral (y-direction) eddy diffusivity of reactant A, D_tA,y, becomes small, but the lateral eddy diffusivity of reactant B, D_tB,y, becomes large because of the chemical reaction. In the outer region of the jet flow, the chemical reaction has the opposite effect on D_tA,y and D_tB,y, and the chemical reaction makes D_tA,y large, but D_tB,y small. It is concluded that the gradient diffusion hypothesis is largely affected by the chemical reaction, and this effect of chemical reaction should be taken into account when the gradient diffusion model is used to estimate turbulent mass fluxes of reactive scalar.
"Sonocytometry" - Novel Diagnostic Method of Ultrasonic Differentiation of Cells in Blood Flow Peer-reviewed

Yosuke Komatsu, Ryo Nagaoka, Ken-ichi Funamoto, Toshiyuki Hayase, Nobuo Masauzi, Hiroshi Kanai, Yoshifumi Saijo

2014 36TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　2014　2761-2764　2014

DOI： 10.1109/EMBC.2014.6944195 　

ISSN： 1557-170X
Relevance of turbulence behind the single square grid to turbulence generated by regular- and multiscale-grids Peer-reviewed

Yi Zhou, Kouji Nagata, Yasuhiko Sakai, Hiroki Suzuki, Yasumasa Ito, Osamu Terashima, Toshiyuki Hayase

Physics of Fluids　26　(7)　2014

DOI： 10.1063/1.4890746 　

ISSN： 1070-6631

eISSN： 1089-7666
Effects of Time-Varying Feedback Signals on Pressure Field in Ultrasonic-Measurement-Integrated Simulation of Pulsatile Blood Flow Peer-reviewed

K. Funamoto, T. Hayase

Proceedings of the 3rd International Conference on Computational and Mathematical Biomedical Engineering (CMBE13)　295-298　2013/12/17
Direct numerical simulation of fractal-generated turbulence Peer-reviewed

H. Suzuki, K. Nagata, Y. Sakai, T. Hayase, Y. Hasegawa, T. Ushijima

Fluid Dynamics Research　45　(6)　061409　2013/12

DOI： 10.1088/0169-5983/45/6/061409 　

ISSN： 0169-5983
Numerical Simulation of Ultrasound Imaging for Detection of Microcalcification in Soft Tissue

M. Tanabe, E. Tagomori, L. Liu, K. Funamoto, M. Nishimoto, T. Hayase

Proceedings of the 13th International Symposium on Advanced Fluid Information (AFI-2013)　62-63　2013/11/26
Evaluation of Intracranial Aneurysm Rupture Using MR-Measurement-Integrated Simulation

S. Sugiyama, K. Funamoto, D. Suzuki, T. Hayase, T. Tominaga

Proceedings of the 13th International Symposium on Advanced Fluid Information (AFI-2013)　86-87　2013/11/26
In-Depth Investigation of Twinkling Sign: Optical Observation of Ultrasound Radiation Force Driven Oscillation of Glass Particle

L. Liu, K. Funamoto, M. Tanabe, T. Hayase

Proceedings of the 13th International Symposium on Advanced Fluid Information (AFI-2013)　58-59　2013/11/26
Consideration on the Evaluation Function of Blood Flow Rate Estimation in Ultrasonic-Measurement-Integrated Simulation

Hiroko Kadowaki, Toshiyuki Hayase, Kenichi Funamoto, Shusaku Sone, Takao Jibiki, Hiroshi Hashimoto, Koji Miyama, Lei Liu

Proceedings of 7th East Asian Consortium on Biomedical Engineering　64-65　2013/11/18
Improvement of Simultaneous Analysis System for Blood Pressure and Flow Velocity Using Photoplethymography and Ultrasonic-Measurement-Integrated Simulation

Shusaku Sone, Toshiyuki Hayase, Kenichi Funamoto, Atsushi Shirai

Proceedings of the 7th East Asian Consortium on Biomedical Engineering　66-67　2013/11/18
Numerical Simulation of Reactive Planar Jet by Combining the Probability Density with Direct Numerical Simulation Peer-reviewed

WATANABE TOMOAKI, SAKAI YASUHIKO, NAGATA KOJI, TERASHIMA OSAMU, ITO YASUMASA, HAYASE TOSHIYUKI

日本機械学会論文集 B編(Web)　79　(807)　2434-2445　2013/11

DOI： 10.1299/kikaib.79.2434 　

ISSN： 1884-8346
An attempt to improve accuracy of higher-order statistics and spectra in direct numerical simulation of incompressible wall turbulence by using the compact schemes for viscous terms Peer-reviewed

H. Suzuki, K. Nagata, Y. Sakai, T. Hayase, Y. Hasegawa, T. Ushijima

International Journal for Numerical Methods in Fluids　73　(6)　509-522　2013/10/30

DOI： 10.1002/fld.3810 　

ISSN： 0271-2091 1097-0363
Computational simulation of convection-enhanced drug delivery in the non-human primate brainstem: a simple model predicting the drug distribution Peer-reviewed

Shin-ichiro Sugiyama, Ryuta Saito, Kenichi Funamoto, Toshio Nakayama, Yukihiko Sonoda, Yoji Yamashita, Tomoo Inoue, Toshihiro Kumabe, Toshiyuki Hayase, Teiji Tominaga

NEUROLOGICAL RESEARCH　35　(8)　773-781　2013/10

DOI： 10.1179/1743132813Y.0000000215 　

ISSN： 0161-6412
Ultrasonic-Measurement-Integrated Simulation of Complex Blood Flow

K. Funamoto, T. Hayase

Proceedings of the International Workshop on Flow Dynamics Related to Energy, Aerospace and Material Science　1-2　2013/09/11
Direct Numerical Simulation of Single-Square Grid-Generated Turbulence Peer-reviewed

Y. Zhou, K. Nagata, Y. Sakai, H. Suzuki, Y. Ito, O. Terashima, T. Hayase

Proc. of the 4th International Conference on Jets, Wakes and Separated Flows　2013/09
DNS study on Small-Scale Characteristics of Fractal-Generated Turbulence Peer-reviewed

H. Suzuki, K. Nagata, Y. Sakai, T. Hayase, Y. Hasegawa, T. Ushijima

Proc. of the 4th International Conference on Jets, Wakes and Separated Flows　2013/09
Effects of Initial Condition on Coherent Structure and Evolution of Turbulent Plane Jets Peer-reviewed

N. Wu, Y. Sakai, K. Nagata, H. Suzuki, O. Terashima, T. Hayase

Proc. of the 4th International Conference on Jets, Wakes and Separated Flows　2013/09
Study on the Effects of Grid-Generated Turbulence on the Initial Growth of Turbulent Boundary Layer by Direct Numerical Simulation Peer-reviewed

S. Xia, Y. Ito, K. Nagata, Y. Sakai, H. Suzuki, O. Terashima, T. Hayase

Proc. of the 4th International Conference on Jets, Wakes and Separated Flows　2013/09
Analysis of Flow Characteristics of Turbulent Plane Jets Based on Velocity and Scalar Fields Using DNS Peer-reviewed

N. Wu, Y. Sakai, K. Nagata, H. Suzuki, O. Terashima, T. Hayase

Journal of Fluid Science and Technology　8　(3)　247-261　2013/08
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jfst.8.247 　

ISSN： 1880-5558

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Turbulent plane jets are prototypical free shear flows on which fundamental research can expand the overall understanding of turbulent flows. In this study, flow characteristics of the turbulent plane jets are studied by means of direct numerical simulation (DNS) based on the finite difference method. The effects of the initial conditions at the jet exit (i.e. Reynolds number and velocity profile) on the spatial development of velocity and scalar fields are mainly investigated. Meanwhile the instantaneous coherent structures, based on the Q-criterion and the local minimum of pressure, are presented. The results suggest that the plane jet flow with the higher Re (=U_bd/ν : U_b is the bulk mean velocity at the jet exit, d is the slot width, and ν is the kinematic viscosity) and the parabola velocity profile at the jet exit will correspond to the shorter potential core, furthermore, the lower Re and the parabola velocity profile will strengthen the decay of the mean field in the process of flow transition to full turbulence. The flow self-similarity will be achieved at shorter streamwise distance from the jet exit for the higher Re and the parabola velocity profile at the jet exit. Moreover, the dependency of coherent structures on the initial Reynolds number is remarkable, especially in the flow development region, but the change of initial velocity profile at the jet exit hardly acts on the scale of coherent structures. It is also observed that the scalar field is more sensitive to changes of initial conditions than the velocity field.
DNS on Multiscale-Generated Grid Turbulence Using Classical Grid Peer-reviewed

H. Suzuki, K. Nagata, Y. Sakai, T. Hayase, Y. Hasegawa, T. Ushijima

Proc. of the 8th International Symposium on Turbulence and Shear Flow Phenomena　2013/08
In vitro study of ultrasound radiation force-driven twinkling sign using PVA-H gel and glass beads tissue-mimicking phantom. Peer-reviewed

Lei Liu, Kenichi Funamoto, Kei Ozawa, Makoto Ohta, Toshiyuki Hayase, Masafumi Ogasawara

Journal of medical ultrasonics (2001)　40　(3)　197-203　2013/07

DOI： 10.1007/s10396-012-0429-9 　

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The twinkling sign observed in ultrasound coded-excitation imaging (e.g., GE B-Flow) has been reported in previous research as a potential phenomenon to detect micro calcification in soft tissue. However, the mechanism of the twinkling sign has not been clearly understood yet. We conducted an in vitro experiment to clarify the mechanism of the twinkling sign by measuring a soft tissue-mimicking phantom with ultrasonic and optical devices. A soft tissue-mimicking phantom was made of poly(vinyl alcohol) hydro (PVA-H) gel and 200-μm-diameter glass beads. We applied ultrasound to the phantom using medical ultrasound diagnostic equipment to observe the twinkling sign of glass beads. Optical imaging with a laser sheet and a high-speed camera was performed to capture the scatter lights of the glass beads with and without ultrasound radiation. The scatter lights from the glass beads were quantified and analyzed to evaluate their oscillations driven by the ultrasound radiation force. The twinkling sign from the glass beads embedded in the PVA-H gel soft tissue phantom was observed in ultrasound B-Flow color imaging. The intensity and oscillation of the scattered lights from the glass beads showed significant difference between the cases with and without ultrasound radiation. The results showed a close relationship between the occurrence of the twinkling sign and the variations of the scatter lights of glass beads, indicating that ultrasound radiation force-driven micro oscillation causes the twinkling sign of micro calcification in soft tissue.
Reproduction of pressure field in ultrasonic-measurement-integrated simulation of blood flow Peer-reviewed

Kenichi Funamoto, Toshiyuki Hayase

INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING　29　(7)　726-740　2013/07

DOI： 10.1002/cnm.2522 　

ISSN： 2040-7939

eISSN： 2040-7947
Frictional Characteristics of Erythrocytes on Endothelia-Cultured or Material-Coated Glass Plates Subject to Inclined Centrifugal Forces Invited

Toshiyuki Hayase, Kousuke Inoue, Kenichi Funamoto, Atsushi Shirai

Proceedings of 8th International Conference on Multiphase Flow　1-8　2013/05/29
The Kinematics of Jumping of Globular Springtail Peer-reviewed

Seiichi Sudo, Masahiro Shiono, Toshiya Kainuma, Atsushi Shirai, Toshiyuki Hayase

Journal of Aero Aqua Bio-mechanisms　3　(1)　85-91　2013/05
Publisher: Society of Aero Aqua Bio-mechanisms
DOI： 10.5226/jabmech.3.85 　

ISSN： 2185-1522

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This paper describes jumping behaviour of the globular springtails. Direct observations on the jumping and climbing behaviour of springtails were conducted in the laboratory. The kinematics of jumping in tiny springtails was analyzed with high-speed video camera system. The vertical climbing behaviour was analyzed in contrast to the jumping behaviour. The jumping performance of springtails was revealed.
Observations on the Springtail Leaping Organ and Jumping Mechanism Worked by a Spring Peer-reviewed

Seiichi Sudo, Masahiro Shiono, Toshiya Kainuma, Atsushi Shirai, Toshiyuki Hayase

Journal of Aero Aqua Bio-mechanisms　3　(1)　92-96　2013/05
Publisher: Society of Aero Aqua Bio-mechanisms
DOI： 10.5226/jabmech.3.92 　

ISSN： 2185-1522

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This paper is concerned with a small jumping mechanism. Microscopic observations of springtail leaping organs were conducted using a confocal leaser scanning microscope. A simple springtail mechanism using a spring and small electromagnet was produced based on the observations of leaping organ and the jumping analysis of the globular springtail. Jumping characteristics of the mechanism were examined with high-speed video camera system.
超音波Mモードイメージングと光電容積脈波センシングによる脈波同定の比較

曾根周作, 早瀬敏幸, 船本健一

超音波医学　40　(Suppl.)　S429-S429　2013/04
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176

eISSN： 1881-9311
INFLUENCE OF PLAQUE STIFFNESS ON CHANGE OF BLOOD VESSEL GEOMETRY LEADING HEMODYNAMICAL CHANGES IN PVA-H STENOSIS MODELS Peer-reviewed

Yasutomo Shimizu, Shuya Shida, Kenichi Funamoto, Toshiyuki Hayase, Makoto Ohta

INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION - 2012, VOL 2: BIOMEDICAL AND BIOTECHNOLOGY　IMECE2012　455-460　2013

DOI： 10.1115/IMECE2012-87073 　
Mechanism of blast-induced traumatic brain injury Peer-reviewed

Nakagawa A, Ohtani K, Goda K, Arafune T, Washio T, Hayase T, Tominaga T

Proceedings of the Thirteenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　72-73　2013
Simultaneous Analysis System for Blood Pressure and Flow Using Photoplethysmography and Ultrasonic-Measurement-Integrated Simulation Peer-reviewed

Shusaku Sone, Toshiyuki Hayase, Kenichi Funamoto, Atsushi Shirai

2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　1827-1830　2013

DOI： 10.1109/EMBC.2013.6609878 　

ISSN： 1557-170X
Fundamental Study on Micro Calcification Detection Using Twinkling Sign (TS): The Effect of Stiffness of Surrounding Tissue on the Appearance of TS Peer-reviewed

Lei Liu, Kenichi Funamoto, Masayuki Tanabe, Toshiyuki Hayase

2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　1390-1393　2013

DOI： 10.1109/EMBC.2013.6609769 　

ISSN： 1557-170X
DNS-PDF simulation of turbulent mixing in a reactive planar jet Peer-reviewed

Tomoaki Watanabe, Yasuhiko Sakai, Kouji Nagata, Yasumasa Ito, Osamu Terashima, Toshiyuki Hayase

Communications in Computer and Information Science　402　445-452　2013
Publisher: Springer
DOI： 10.1007/978-3-642-45037-2_49 　

ISSN： 1865-0929
A Topologically-Enhanced Juxtaposition Tool for Hybrid Wind Tunnel Peer-reviewed

Yuriko Takeshima, Issei Fujishiro, Shigeo Takahashi, Toshiyuki Hayase

2013 IEEE SYMPOSIUM ON PACIFIC VISUALIZATION (PACIFICVIS)　113-120　2013

DOI： 10.1109/PacificVis.2013.6596135 　

ISSN： 2165-8765
Flow observations in elastic stenosis biomodel with comparison to rigid-like model Peer-reviewed

Yasutomo Shimizu, Ashkan Javadzadegan, Toshiyuki Hayase, Makoto Ohta

TECHNOLOGY AND HEALTH CARE　21　(4)　305-314　2013

DOI： 10.3233/THC-130725 　

ISSN： 0928-7329

eISSN： 1878-7401
Visualization of turbulent reactive jet by using direct numerical simulation Peer-reviewed

Tomoaki Watanabe, Yasuhiko Sakai, Kouji Nagata, Osamu Terashima, Hiroki Suzuki, Toshiyuki Hayase, Yasumasa Ito

International Journal of Modeling, Simulation, and Scientific Computing　4　(SUPPL.1)　1341001　2013

DOI： 10.1142/S1793962313410018 　

ISSN： 1793-9623

eISSN： 1793-9615
Fundamental Study on Micro Calcification Detection Using Twinkling Sign (TS): The Effect of Stiffness of Surrounding Tissue on the Appearance of TS Peer-reviewed

Lei Liu, Kenichi Funamoto, Masayuki Tanabe, Toshiyuki Hayase

2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　1390-1393　2013

DOI： 10.1109/EMBC.2013.6609769 　

ISSN： 1557-170X
Simultaneous Analysis System for Blood Pressure and Flow Using Photoplethysmography and Ultrasonic-Measurement-Integrated Simulation Peer-reviewed

Shusaku Sone, Toshiyuki Hayase, Kenichi Funamoto, Atsushi Shirai

2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　1827-1830　2013

DOI： 10.1109/EMBC.2013.6609878 　

ISSN： 1557-170X
Numerical Simulation of Reactive Planar Jet by Combining the Probability Density Function Method with Direct Numerical Simulation Peer-reviewed

WATANABE Tomoaki, SAKAI Yasuhiko, NAGATA Kouji, TERASHIMA Osamu, ITO Yasumasa, HAYASE Toshiyuki

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series B　79　(807)　2434-2445　2013
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.79.2434 　

ISSN： 0387-5016

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Direct numerical simulation (DNS) is combined with probability density function (PDF) methods to simulate turbulent reactive flows. DNS is performed to predict an instantaneous velocity field and an instantaneous mixture fraction, whereas reactive scalars are predicted by the PDF method, in which a transport equation of joint PDF of reactive scalars is solved by using a large number of particles. We develop a new model for a mixing timescale of mixing model, which is used in the PDF method. In the present model, the mixing timescale is estimated from the mixture fraction predicted by the DNS. The numerical simulation based on the DNS and the PDF method is applied to a reactive planar jet. The results show that the PDF method can accurately predict the statistics of mixture fraction, and the present model for the mixing timescale can implicitly take into account the effect of distance between two particles without adjusting any model parameters. It is also found that the PDF method can accurately predict the statistics of reactive scalars.
DNS-PDF simulation of turbulent mixing in a reactive planar jet Peer-reviewed

Tomoaki Watanabe, Yasuhiko Sakai, Kouji Nagata, Yasumasa Ito, Osamu Terashima, Toshiyuki Hayase

Communications in Computer and Information Science　402　445-452　2013

DOI： 10.1007/978-3-642-45037-2_49 　

ISSN： 1865-0929
Direct numerical simulation of grid-generated turbulence (analysis on invariants and rotta model) Peer-reviewed

Hiroki Suzuki, Kouji Nagata, Yasuhiko Sakai, Toshiyuki Hayase, Yutaka Hasegawa, Tatsuo Ushijima

Nihon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japan Society of Mechanical Engineers, Part B　79　(807)　2363-2374　2013
Publisher: Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.79.2363 　

ISSN： 0387-5016
植物表面細胞の形状計測－植物流体力学的アプローチ－ Peer-reviewed

須藤誠一, 塩野正裕, 白井敦, 早瀬敏幸

実験力学　12　(4)　338-343　2012/12
Publisher:
DOI： 10.11395/jjsem.12.338 　

ISSN： 1346-4930
Erratum to "Influence of surface model extraction parameter on computational fluid dynamics modeling of cerebral aneurysms" [Journal of Biomechanics 45 (2012) 2355-2361] Peer-reviewed

Shunsuke Omodaka, Takashi Inoue, Kenichi Funamoto, Shin-ichirou Sugiyama, Hiroaki Shimizu, Toshiyuki Hayase, Akira Takahashi, Teiji Tominaga

Journal of Biomechanics　45　(16)　2947　2012/11/15

DOI： 10.1016/j.jbiomech.2012.09.012 　

ISSN： 0021-9290 1873-2380

eISSN： 1873-2380
Integration of CFD and EFD for Analysis of Complex Real Flows Invited

Toshiyuki Hayase

5th Symposium on Integrating CFD and Experiments in Aerodynamics (Integration 2012)　2012/10/04
Rheological Analysis of the Mechanism of Fetal Brain Hemorrhage

T. Ito, K. Funamoto, K. Funamoto, T. Hayase, Y. Kimura

Proceedings of the 12th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2012)　116-117　2012/09/20
Magnetic Resonance Fluid Dynamics for Intracranial Aneurysms

S. Sugiyama, K. Funamoto, T. Hayase, T. Tominaga

Proceedings of the 12th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2012)　118-119　2012/09/20
Numerical Analysis of Levitation Mechanism of Red Blood Cell in Inclined Centrifuge Microscope - Effect of Asymmetric Cell Shape on the Motion

Takashi OSHIBE, Toshiyuki HAYASE, Kenichi FUNAMOTO, Atsushi SHIRAI

Proceedings of the 9th International Conference on Flow Dynamics (ICFD2012)　756-757　2012/09/20
Ultrasound Radiation Force Driven B-Flow Twinkling Sign for Microcalcification Detection

L. Liu, K. Funamoto, K. Ozawa, M. Ohta, T. Hayase, M. Ogasawara

Proceedings of the 12th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2012)　86-87　2012/09/20
Intra-left Atrial Flow

M. Shibata, T. Yambe, K. Funamoto, T. Hayase

Proceedings of the 9th International Conference on Flow Dynamics (ICFD2012)　404-405　2012/09/19
Measurement of Pressure Drop for Modeling Intracranial Flow Diverter Stent Using Porous Medium

Yukihisa Miura, Hitomi Anzai, Toshio Nakayama, Toshiyuki Hayase, Makoto Ohta

Proceedings Ninth International Conference on Flow Dynamics　586-587　2012/09
Influence of surface model extraction parameter on computational fluid dynamics modeling of cerebral aneurysms Peer-reviewed

Shunsuke Omodaka, Takashi Inoue, Kenichi Funamoto, Shin-ichirou Sugiyama, Hiroaki Shimizu, Toshiyuki Hayase, Akira Takahashi, Teiji Tominaga

JOURNAL OF BIOMECHANICS　45　(14)　2355-2361　2012/09

DOI： 10.1016/j.jbiomech.2012.07.006 　

ISSN： 0021-9290
Neumerical and Experimental Study of Flow in Stenosis models with Several Mechanical Properties

Yasutomo Shimizu, Shuya Shida, Ashkan Javadzadegan, Kenichi Funamoto, Toshiyuki Hayase, Makoto Ohta

Proceedings Ninth International Conference on Flow Dynamics　422-423　2012/09
The Jump of the Globular Springtail and Jumping Mechanism Worked by a Spring

S. Sudo, M. Shiono, A. Shirai, T. Hayase

Proceedings of the 5th International Symposium on Aero Aqua Bio-mechanisms　2012/08
Influence of Pressing Force on Motion of HL60 Cells on HUVEC substrate

A. Shirai, H. Uranuma, T. Hayase

Journal of Biomechanics　45　(1)　S41　2012/07
Motion of fMLP-Stimulated HL60 Cells on HUVEC Cultured on a Flat Glass Plate Peer-reviewed

A. Shirai, H. Sato, T. Hayase

Proceedings of Surface Modification Technologies XXVI　2012/06
2次元超音波計測融合シミュレーションによる頸動脈分岐部の非定常血流量推定

門脇弘子, 船本健一, 早瀬敏幸, 曾根周作, 小笠原正文, 地挽隆夫, 橋本浩, 見山広二

超音波医学　39　(Suppl.)　S338-S338　2012/04
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176

eISSN： 1881-9311
Behavior of HL60 cells on HUVEC substrate under inclined centrifugal forces

A. Shirai, H. Uranuma, T. Hayase

2012 Annual ELyT Workshop Abstract Book　2012/03
DYNAMICS IN MOTION OF DANDELION FLOWER HEAD Peer-reviewed

Seiichi Sudo, Masahiro Shiono, Atsushi Shirai, Toshiyuki Hayase

ICEM15: 15TH INTERNATIONAL CONFERENCE ON EXPERIMENTAL MECHANICS　2012
Propagation of Shock Wave within Complex Biomaterial Layer: Implications for the Mechanism Blast-Induced Traumatic Brain Injury Peer-reviewed

Nakagawa A, Ohtani K, Goda K, Arafune T, Washio T, Hayase T, Tominaga T

Proceedings of the Twelfth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　124-125　2012
Investigation of eddy diffusivity in a reactive plane jet by using direct numerical simulation Peer-reviewed

Tomoaki Watanabe, Yasuhiko Sakai, Kouji Nagata, Osamu Terashima, Yasumasa Ito, Hiroki Suzuki, Toshiyuki Hayase

Communications in Computer and Information Science　323 CCIS　(PART 1)　144-150　2012

DOI： 10.1007/978-3-642-34384-1_18 　

ISSN： 1865-0929
Local Hemodynamics at the Rupture Point of Cerebral Aneurysms Determined by Computational Fluid Dynamics Analysis Peer-reviewed

Shunsuke Omodaka, Shin-ichirou Sugiyama, Takashi Inoue, Kenichi Funamoto, Miki Fujimura, Hiroaki Shimizu, Toshiyuki Hayase, Akira Takahashi, Teiji Tominaga

CEREBROVASCULAR DISEASES　34　(2)　121-129　2012

DOI： 10.1159/000339678 　

ISSN： 1015-9770
Flow Analysis of Rupture Point in Cerebral Aneurysms: Computational Fluid Dynamics Study

S. Omodaka, T. Inoue, K. Funamoto, S. Sugiyama, M. Fujimura, H. Shimizu, T. Hayase, A. Takahashi, T. Tominaga

Proceedings on the 5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering　68-69　2011/12/13
Numerical Analysis of the Effect of Angle of Attack on a Red Blood Cell Moving in an Inclined Centrifuge Microscope

T. Oshibe, T. Hayase, K. Funamoto, A. Shirai

Proceedings on the 5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering　82-83　2011/12/13
Two-Dimensional Ultrasonic-Measurement-Integrated Simulation of Blood Flow in Bifurcation of Carotid Artery

H. Kadowaki, K. Funamoto, T. Hayase, S. Sone, M. Ogasawara, T. Jibiki, H. Hashimoto, K. Miyama

Proceedings on the 5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering　80-81　2011/12/13
Implementation of visual data mining for unsteady blood flow field in an aortic aneurysm Peer-reviewed

Seiichiro Morizawa, Koji Shimoyama, Shigeru Obayashi, Kenichi Funamoto, Toshiyuki Hayase

JOURNAL OF VISUALIZATION　14　(4)　393-398　2011/12

DOI： 10.1007/s12650-011-0101-2 　

ISSN： 1343-8875
Comparison between Ultrasonic-Measurement-Integrated Simulation and Ordinary Simulation with Measured Upstream Velocity Condition

S. Sone, T. Kato, K. Funamoto, T. Hayase, M. Ogasawara, T. Jibiki, H. Hashimoto, K. Miyama

Proceedings of the 8th International Conference on Flow Dynamics　456-457　2011/11/10
Computational Simulation of Blood Flow in Intracranial Aneurysms under Patient-Specific Pulsatile Inlet Condition

S. Sugiyama, K. Funamoto, T. Hayase, T. Tominaga

Proceedings of the 11th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2011)　90-91　2011/11/10
Detection of Microcalcification in Soft Tissue Employing B-Flow ”Twinkling” Sign

L. Liu, K. Ozawa, K. Funamoto, M. Ohta, T. Hayase, M. Ogasawara

Proceedings of the 11th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2011)　94-95　2011/11/10
Left Atrial Vortex

M. Shibata, T. Yambe, K. Funamoto, T. Hayase

Proceedings of the 11th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2011)　88-89　2011/11/10
Volumetric and Angiogenic Evaluation of Antitumor Effects with Acoustic Liposome and High-Frequency Ultrasound Peer-reviewed

Tetsuya Kodama, Noriko Tomita, Yoko Yagishita, Sachiko Horie, Kenichi Funamoto, Toshiyuki Hayase, Maya Sakamoto, Shiro Mori

CANCER RESEARCH　71　(22)　6957-6964　2011/11

DOI： 10.1158/0008-5472.CAN-11-2389 　

ISSN： 0008-5472
Measurement-integrated simulation and visualization of Karman vortex streets in Hybrid Wind Tunnel Invited

TAKESHIMA Yuriko, FUJISHIRO Issei, TAKAHASHI Shigeo, HAYASE Toshiyuki

Proceedings of ASIAGRAPH2011　35-40　2011/10/21
Publisher: Virtual Reality Society of Japan

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We have developed a hybrid wind tunnel, where 2D measurement-integrated (MI) simulation, which utilizes actual data acquired from real air flow behind a square cylinder, plays an important role in improving the accuracy of its numerical analysis. The wind tunnel requires an accompanying visual analysis tool with which we can effectively peer into the relationships between the actual and simulated flow fields. In this paper, we attempt to exploit the augmented reality-style display technique to that end. The basic idea is to instantaneously superimpose the computationally-visualized MI simulated pressure field onto the actual flow velocity structure physically-visualized with oil mist-traced streak lines. Space registration of these two visual sources is rather straight-forward since the fixed cylinder of the wind tunnel is easily identified, whereas visualizing the MI simulated pressure field can be characterized with its sophisticated scheme based on differential topology. Considering the facts that vortex centers are located at local minima in the pressure field, and each minimum is surrounded by a derived topological feature called ravine cycle, we can colorize the field adaptiv
微小な海浜生物のいくつかの移動様式 Peer-reviewed

須藤誠一, 星加恭平, 白井敦, 早瀬敏幸

実験力学　11　(2)　91-100　2011/06
Publisher:
DOI： 10.11395/jjsem.11.91 　

ISSN： 1346-4930
Integration of Ultrasound Color Doppler Imaging and Numerical Simulation

K. Funamoto, T. Kato, T. Hayase

Proceedings of the 2nd International Conference on Computational and Mathematical Biomedical Engineering (CMBE11)　262-265　2011/04/01
Numerical Analysis of Effects of Measurement Errors on Ultrasonic-Measurement-Integrated Simulation Peer-reviewed

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING　58　(3)　653-663　2011/03

DOI： 10.1109/TBME.2010.2095418 　

ISSN： 0018-9294
Statistical properties of a turbulent boundary layer affected by grid-generated turbulence (analysis of spatial development by means of direct numerical simulation) Peer-reviewed

Hiroki Suzuki, Kouji Nagata, Yasuhiko Sakai, Toshiyuki Hayase

Nihon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japan Society of Mechanical Engineers, Part B　77　(775)　737-748　2011

DOI： 10.1299/kikaib.77.737 　

ISSN： 0387-5016
DNS on a spatially developing grid turbulence Peer-reviewed

Hiroki Suzuki, Kouji Nagata, Yasuhiko Sakai, Toshiyuki Hayase

(全文査読付) Proceedings of the 13th European Turbulence Conference　318　032043-(5 pages)　2011

DOI： 10.1088/1742-6596/318/3/032043 　

ISSN： 1742-6588
Numerical analysis of one-dimensional mathematical model of blood flow to reproduce fundamental pulse wave measurement for scientific verification of pulse diagnosis Peer-reviewed

Atsushi Shirai, Tsutomu Nakanishi, Toshiyuki Hayase

Journal of Biomechanical Science and Engineering　6　(4)　330-342　2011

DOI： 10.1299/jbse.6.330 　

ISSN： 1880-9863
Preliminary experiments for investigation on mechanism of contra-coup injury blast-induced traumatic brain injury Peer-reviewed

Nakagawa A, Ohtani K, Goda K, Arafune T, WahioT, Hayase T, Tominaya T

The Eleventh International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　96-97　2011
Hemodynamic changes in the left atrium due to atrial fibrillation

Kenichi Funamoto, Ryo Koizumi, Toshiyuki Hayase, Muneichi Shibata, Tomoyuki Yambe

ASME 2011 Summer Bioengineering Conference, SBC 2011　1131-1132　2011

DOI： 10.1115/SBC2011-53817 　
Erratum to: Implementation of visual data mining for unsteady blood flow field in an aortic aneurysm. Peer-reviewed

Seiichiro Morizawa, Koji Shimoyama, Shigeru Obayashi, Array,Toshiyuki Hayase

J. Visualization　14　(4)　399　2011

DOI： 10.1007/s12650-011-0101-2 　 10.1007/s12650-011-0111-0 　
Blood Flow Analysis in the Left Atrium with/without Atrial Fibrillation

R. Koizumi, K. Funamoto, T. Hayase, M. Shibata

Proceedings on the 4th East Asian Pacific Student Workshop on Nano-Biomedical Engineering　96-97　2010/12/16
Some Theoretical Issues on Measurement-Integrated Simulation Invited

Toshiyuki Hayase

4th East Asian Pacific Student Workshop on Nano-Biomedical Engineering　54-55　2010/12/16
Experimental Validation of Ultrasonic-Measurement-Integrated Blood Flow Simulation Using Carotid Artery Models

T. Sawao, K. Funamoto, T. Hayase

Proceedings on the 4th East Asian Pacific Student Workshop on Nano-Biomedical Engineering　96-97　2010/12/15
Eigenvalue analysis of linearized error dynamics of measurement integrated flow simulation Peer-reviewed

Kentaro Imagawa, Toshiyuki Hayase

COMPUTERS & FLUIDS　39　(10)　1796-1803　2010/12

DOI： 10.1016/j.compfluid.2010.06.008 　

ISSN： 0045-7930
Direct numerical simulation of turbulent mixing in regular and fractal grid turbulence Peer-reviewed

Hiroki Suzuki, Kouji Nagata, Yasuhiko Sakai, Toshiyuki Hayase

PHYSICA SCRIPTA　T142　1-4　2010/12

DOI： 10.1088/0031-8949/2010/T142/014065 　

ISSN： 0031-8949
Stabilization of Measurement-Integrated Simulation by Elucidation of Destabilizing Mechanism Peer-reviewed

Toshiyuki Hayase, Kentaro Imagawa, Kenichi Funamoto, Atsushi Shirai

Journal of Fluid Science and Technology　5　(3)　632-647　2010/12
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jfst.5.632 　

ISSN： 1880-5558

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Measurement-integrated (MI) simulation is a numerical flow analysis method with a feedback mechanism from measurement of a real flow. It correctly reproduces a real flow under inherent ambiguity in a mathematical model or a computational condition. In this paper we theoretically investigated the destabilization phenomenon of MI simulation, in which analysis error suddenly increases at some critical feedback gain. This phenomenon has been considered as instability of a closed-loop feedback system, but present study treated it as that of a numerical scheme. First, the mechanism of the destabilization phenomenon was investigated based on the sufficient condition of the convergence of iterative calculation of existing MI simulation. It was found that the feedback signal in the source term destabilized the iterative calculation. Then, a new MI simulation scheme was derived by evaluating the feedback signal in the linear term to remove the cause of the destabilization. The validity of the present theoretical analysis was verified for examples treated in former studies of MI simulations: blood flow in an aneurismal aorta with ultrasonic measurement, blood flow in a cerebral aneurism with magnetic resonance measurement, Karman vortex street behind a square cylinder with PIV measurement, and fully developed turbulent flow in a square duct with ideal measurement. Occurrences of destabilization phenomenon in all the examples were well explained by the condition of this study, especially for cases of relatively small time steps and large feedback gains. Furthermore, the new MI simulation scheme realized the analysis without the destabilization phenomenon. The present theoretical result confirming that the destabilization phenomenon is not the instability of the feedback system but that of a numerical scheme is generally applicable to MI simulations using the velocity error for the feedback signal.
Observation of velocity of Antibody-modified HL60 cells on glass plates using the inclined centrifuge microscope

Hiroki SATO, Atsushi SHIRAI, Toshiyuki HAYASE

Proceedings on 4th East Asian Pacific Student Workshop on Nano-Biomedical ENgineering　62-63　2010/12
MR-Measurement-Integrated Simulation for Reproduction of Blood Flow in Cerebral Aneurysm Invited

K. Funamoto, T. Hayase

Swiss/Japan International Seminar on Medical Engineering Based on Vessel Biology　2010/11/15
Computer Simulation Predicts the Convective Drug Distribution in the Primate Brainstem

S. Sugiyama, R. Saito, K. Funamoto, Y. Sonoda, T. Kumabe, T. Hayase, T. Tominaga

Proceedings of the tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2010)　98-99　2010/11/02
Consideration for Simulations of Infusion in Realistic Animal Brain Geometries

J. H. Smith, K. Funamoto, K. A. Starkweather, T. Hayase

Proceedings of the tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2010)　96-97　2010/11/02
Detection of Microcalcification in Soft Tissue

L. Liu, M. Ogasawara, K. Ozawa, K. Funamoto, M. Ohta, T. Hayase

Proceedings of the tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2010)　80-81　2010/11/02
Evaluation of Wall Shear Stress on Carotid Artery with Ultrasonic-Measurement-Integrated Simulation

T. Kato, K. Funamoto, T. Hayase, M. Ogasawara, T. Jibiki, H. Hashimoto, K. Miyama

Proceedings of the seventh International Conference on Flow Dynamics　542-543　2010/11/02
Fluid Analysis of the Mechanism of Fetal Brain Hemorrhage

T. Ito, K. Funamoto, K. Funamoto, K. Tanabe, A. Nakamura, T. Hayase, Y. Kimura

Proceedings of the tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2010)　78-79　2010/11/02
Left Atrial Appendage

M. Shibata, T. Yambe, T. Yamaguchi, R. Koizumi, K. Funamoto, T. Hayase

Proceedings of the tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2010)　94-95　2010/11/02
Design of Version Tree Operators for Sophisticated Visualization Provenance

Issei Fujishiro, Yuriko Takeshima, Yuusuke Seshita, Toshiyuki Hayase

Proceedings of The Tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　134-135　2010/11
Direct Numerical Simulation on the Effects of Free-stream Turbulence on an Isothermal Turbulent Boundary Layer

Kouji Nagata, Yasuhiko Sakai, Hiroki Suzuki, Toshiyuki Hayase

Proceedings of The Tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　148-149　2010/11
Experimental Study on Effect of Direction of Endothelial Cells’ Orientation on Motion of HL60 Cells

Haruka URANUMA, Atsushi SHIRAI, Toshiyuki HAYASE

The 7th International Conference on Flow Dynamics　620-621　2010/11
Measurement-Integrated Simulations Applied to a Co-Flowing Jet

Gabriele Bellani, Fredrik Lundell, Outi Tammisola, Kentaro Imagawa, Hiroshi Higuchi, Toshiyuki Hayase

The 7th International Conference on Flow Dynamics　134-135　2010/11
Numerical experiment of measurement-integrated simulation to reproduce turbulent flows with feedback loop to dynamically compensate the solution using real flow information Peer-reviewed

Kentaro Imagawa, Toshiyuki Hayase

COMPUTERS & FLUIDS　39　(9)　1439-1450　2010/10

DOI： 10.1016/j.compfluid.2010.04.012 　

ISSN： 0045-7930
The Correlation Between Ultrasonographic Findings and Pathologic Features in Breast Disorders Peer-reviewed

Kentaro Tamaki, Hironobu Sasano, Takanori Ishida, Kazuyuki Ishida, Minoru Miyashita, Motohiro Takeda, Masakazu Amari, Narumi Harada-Shoji, Masaaki Kawai, Toshiyuki Hayase, Nobumitsu Tamaki, Noriaki Ohuchi

JAPANESE JOURNAL OF CLINICAL ONCOLOGY　40　(10)　905-912　2010/10

DOI： 10.1093/jjco/hyq070 　

ISSN： 0368-2811
Computational Simulation on Convection-Enhanced Drug Delivery into the Primate Brain

S. Sugiyama, T. Nakayama, K. Funamoto, T. Hayase, T. Tominaga

Abstracts of the 6th World Congress of Biomechanics　578-579　2010/08/04
ナノテクノロジーを応用したテーラーメイド人工心筋 Peer-reviewed

山家智之, 白石泰之, 三浦英和, 馬場敦, 井街宏, 早瀬敏幸, 円山重直, 柴田宗一, 三引義明, 大沢上, 佐藤尚

東北医誌　122　65-70　2010/06
Measurement-Integrated Simulations and Kalman Filter Applied to a Co-Flowing Jet Peer-reviewed

Kentaro Imagawa, Gabriele Bellani, Outi Tammisola, Fredrik Lundell, Hiroshi Higuchi, Toshiyuki Hayase

Seventh International Conference on Flow Dynamics　1-23　2010/06
Anisotropic In Vitro Vessel Model Using Poly(vinyl Alcohol) Hydro Gel and Mesh Material Peer-reviewed

Lei Liu, Hiroyuki Kosukegawa, Makoto Ohta, Toshiyuki Hayase

JOURNAL OF APPLIED POLYMER SCIENCE　116　(4)　2242-2250　2010/05

DOI： 10.1002/app.31687 　

ISSN： 0021-8995
Determination of Local Fine Structure of Blood Flows by Measurement Coupled Simulation Invited

T. Hayase, K. Funamoto, K. Imagawa

Proceedings of 12th International Symposium of Tohoku University Global COE Programme Global Nano-Biomedical Engineering Education and Research Network Centre　89-92　2010/03
Eigenvalue Analysis for Error Dynamics of Measurement-Integrated Simulation of Blood Flow

K. Imagawa, T. Funamoto, T. Hayase

Proceedings of 12th International Symposium of Tohoku University Global COE Programme Global Nano-Biomedical Engineering Education and Research Network Centre　109-110　2010/03
Clinical Application of Ultrasonic-Measurement-Integrated Simulation for Diagnosis of Carotid Artery

K. Funamoto, T. Kato, T. Hayase, M. Ogasawara, T. Jibiki, H. Hashimoto, K. Miyama

Proceedings of SMART-Tohoku GCOE joint Workshop on Micro & Nano Bioengineering: MIT, NUS, NTU and Tohoku　41-42　2010/01/12
G0200-1-5 Fundamental observation of microscopic behavior of HL60 cells on glass plate using the inclined centrifuge microscope

Sato Hiroki, Shirai Atsushi, Hayase Toshiyuki

The proceedings of the JSME annual meeting　2010　9-10　2010
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2010.5.0_9 　

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The authors have investigated the adhesion and friction characteristics of the neutrophils on a flat glass plate using the inclined centrifuge microscope. In their studies, however, precise behavior of the neutrophils on the plate has not been observed. In this study, microbeads were attached on the HL60 cells, a model cell of neutrophils, via an antibody as marker particles to observe if the cells were rolling or sliding on the plate. Some cells were observed to roll on the glass plate and showed the stick-slip motion. Influence of stimulation of the HL60 cells by the antibody on their adhesivity to the plate was also investigated with respect to the adhesion ratio. It was shown that the adhesion ratio of the stimulated cells did not change with coating of the plate with the MPC polymer which prevents the cells adhesion, while that of the not-stimulated cells decreased drastically.
Turbulence structure of multiscale generated turbulence by fractal grids and scalar transfer mechanism (2nd report, DNS on the influence of grid parameters on homogeneity, isotropy and intermittency) Peer-reviewed

Hiroki Suzuki, Kouji Nagata, Yasuhiko Sakai, Toshiyuki Hayase

Nihon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japan Society of Mechanical Engineers, Part B　76　(772)　2024-2031　2010
Publisher: Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.76.772_2024 　

ISSN： 0387-5016
Visual Data Mining for Unsteady Blood Flow Field, Peer-reviewed

S. Morizawa, K. Shimoyama, S. Obayashi, K. Funamoto, T. Hayase

OE-001　2010
VISUALIZATION OF MICROCIRCULATION BASED ON BRIGHTNESS VARIATION IN CONTRAST-ENHANCED ULTRASOUND

Kenichi Funamoto, Toshiyuki Hayase, Tetsuya Kodama

PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, 2010　219-220　2010

DOI： 10.1115/SBC2010-19349 　
A Stabilization Technique of Wobbly Images Taken by the Inclined Centrifuge Microscope Peer-reviewed

A. Shirai, T. Hayase

6TH WORLD CONGRESS OF BIOMECHANICS (WCB 2010), PTS 1-3　31　1570-1573　2010

DOI： 10.1007/978-3-642-14515-5_400 　

ISSN： 1680-0737
Effect of Measurement Error on Ultrasonic-Measurement-Integrated Simulation of Blood Flow in an Aortic Aneurysm

K. Funamoto, T. Hayase, Y. Saijo, T. Yambe

6TH WORLD CONGRESS OF BIOMECHANICS (WCB 2010), PTS 1-3　31　1652-+　2010

ISSN： 1680-0737
Experimental Observation of Behavior of Neutrophil-like HL60 Cells on Oriented Endothelial Cells

Haruka Uranuma, Atsushi Shirai, Toshiyuki Hayase

Proceedings of 3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering　22-23　2009/12
Analysis of Clinical Data with Ultrasonic-Measurement-Integrated Simulation

T. Kato, K. Funamoto, T. Hayase, M. Ogasawara, T. Jibiki, H. Hashimoto, K. Miyama

Proceedings of the 3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering　102-103　2009/12
Dynamic Characteristics Analysis of Diseased Circulatory System with Lumped Parameter Model 1st Report : Heart Valve Disease

R. Koizumi, T. Hayase, K. Funamoto

Proceedings of the 3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering　6-7　2009/12
Eigenvalue Analysis for Error Dynamics of Ultrasonic-Measurement-Integrated Simulation of Blood Flow in the Aneurismal Aorta

K. Imagawa, T. Hayase, K. Funamoto

Proceedings of the 3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering　114-115　2009/12
Three-Dimensional Ultrasonic-Measurement-Integrated Blood flow Simulation using PVA Carotid Artery Model

T. Suzuki, T. Hayase, K. Funamoto, K. Inoue

Proceedings of the 3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering　116-117　2009/12
埋め込み境界法と高精度差分によるフラクタル格子乱流の三次元直接数値計算 Peer-reviewed

鈴木博貴, 長田孝二, 酒井康彦, 早瀬敏幸

数理科学会論文集　11　(1)　33-38　2009/12
Publisher:
ISSN： 1345-5206
Atrial Vortex

M. Shibata, H. Ito, T. Yambe, R. Koizumi, K. Funamoto, T. Hayase

Proceedings of the 9th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　64-65　2009/11/05
Blood Flow Analysis by Measurement-Integrated Simulation

K. Funamoto, T. Hayase

Proceedings of the 9th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　120-121　2009/11/05
Convection-enhanced Delivery of ACNU under MRI Monitoring against Recurrent Gliomas-Development of Computational Simulation of Drug Distribution

R. Saito, Y. Sonoda, T. Kumabe, K. Funamoto, T. Hayase, T. Tominaga

Proceedings of the 9th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　72-73　2009/11/05
Fundamental Study of Convection-Enhanced Delivery Simulation in Rat Brain

J.H. Smith, K. Funamoto, M.V. Racenis, T. Hayase

Proceedings of the 9th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　70-71　2009/11/05
フラクタル格子により生成されるマルチスケール誘起乱流の構造とスカラー拡散機構（第１報，DNSによるフラクタル基本形状の影響に関する検討） Peer-reviewed

鈴木博貴, 長田孝二, 酒井康彦, 早瀬敏幸, 久保貴

日本機械学会論文集（Ｂ編）　75　(755)　1387-1394　2009/07
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.75.755_1387 　

ISSN： 0387-5016

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Turbulence characteristics in the spatially developing fractal-generated turbulence are investigated by means of the direct numerical simulation (DNS). Three kinds of fractal grids, namely, cross, I and square types, are numerically constructed using the immersed boundary method. The results show that fractal grids generate high turbulence intensities compared with the classical grid turbulence using a biplane square mesh grid at the same mesh Reynolds number. Among the three types, the fractal square grid is the best to generate nearly homogeneous and isotropic turbulence in the far downstream decaying region. The integral length scale in the fractal generated turbulence remains approximately constant in the decaying region, whereas it grows downstream in the classical grid turbulence. These results are in good agreement with the previous experiments.
Numerical Validation of MR-Measurement-Integrated Simulation of Blood Flow in a Cerebral Aneurysm Peer-reviewed

Kenichi Funamoto, Yoshitsugu Suzuki, Toshiyuki Hayase, Takashi Kosugi, Haruo Isoda

ANNALS OF BIOMEDICAL ENGINEERING　37　(6)　1105-1116　2009/06

DOI： 10.1007/s10439-009-9689-y 　

ISSN： 0090-6964
Effect of Aliasing on Ultrasonic-Measurement-Integrated Simulation of Three-Dimensional Unsteady Blood Flow

K. Funamoto, T. Hayase, K. Imagawa, Y. Saijo, T. Yambe

Proceedings of the 10th International Symposium of 2007 Tohoku University Global COE Program “Global Nano-Biomedical Engineering Education and Research Network Centre”　18-19　2009/04/17
Fluid-Structure Coupled Ultrasonic-Measurement-Integrated Simulation of Fluid in Elastic Tube with Contraction

L. Liu, T. Hayase, K. Funamoto

Proceedings of 9th International Symposium of Tohoku University Global COE Programme Global Nano-Biomedical Engineering Education and Research Network Centre　106-107　2009/03
Experimental and Numerical Study of Forward Flight Aerodynamics of Insect Flapping Wing Peer-reviewed

Hiroto Nagai, Koji Isogai, Tatsumi Fujimoto, Toshiyuki Hayase

AIAA JOURNAL　47　(3)　730-742　2009/03

DOI： 10.2514/1.39462 　

ISSN： 0001-1452
J0203-3-2 Experimental Observation of influence of Orientation of Endothelial Cells on Motion of Neutrophils

URANUMA Haruka, SHIRAI Atsushi, HAYASE Toshiyuki

The proceedings of the JSME annual meeting　2009　195-196　2009
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2009.6.0_195 　

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Neutrophils tend to adhere and roll on the endothelial cells (ECs) in blood vessels. In the former research, we observed behavior of neutrophil-like HL60 cells on cultured ECs in terms of the adhesion, ratio and moving velocity using the inclined centrifuge microscope. However, ECs exposed to blood flow are said to be oriented to the flow direction. In this study, we observed the motion of HL60s on oriented and on not-oriented ECs to investigate the influence of the orientation on the behavior of HL60s. Consequently, we found that adhesion ratio of HL60s is lower and the mean velocity is higher on the oriented ECs than not-oriented cells.
Atrial Vortex Measurement by Magnetic Resonance Imaging Peer-reviewed

M. Shibata, T. Yambe, Y. Kanke, T. Hayase

13TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, VOLS 1-3　23　(1-3)　2254-+　2009

ISSN： 1680-0737
Evaluation of Compliance of Poly (vinyl alcohol) Hydrogel for Development of Arterial Biomodeling Peer-reviewed

Kosukegawa, H., Mamada, K., Kuroki, K., Liu, L., Inoue, K., Hayase, T., Ohta, M.

13th International Conference on Biomedical Engineering, Vols 1-3　23　2009
NUMERICAL EXPERIMENT OF MR-MEASUREMENT-INTEGRATED SIMULATION OF STEADY BLOOD FLOW IN A CEREBRAL ANEURYSM

Kenichi Funamoto, Yoshitsugu Suzuki, Toshiyuki Hayase, Takashi Kosugi, Haruo Isoda

PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE 2008, PTS A AND B　1089-1090　2009
Numerical Evaluation of MR-Measurement-Integrated Simulation of Unsteady Hemodynamics in a Cerebral Aneurysm

K. Funamoto, Y. Suzuki, T. Hayase, T. Kosugi, H. Isoda

13TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, VOLS 1-3　23　(1-3)　2188-+　2009

ISSN： 1680-0737
Numerical Experiment of Transient and Steady Characteristics of Ultrasonic-Measurement-Integrated Simulation in Three-Dimensional Blood Flow Analysis Peer-reviewed

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

ANNALS OF BIOMEDICAL ENGINEERING　37　(1)　34-49　2009/01

DOI： 10.1007/s10439-008-9600-2 　

ISSN： 0090-6964
Improvement of the DNS of turbulent channel flow using the finite difference method (Introduction of the compact scheme to the viscous terms for high spatial resolution in the dissipation range) Peer-reviewed

Hiroki Suzuki, Kouji Nagata, Yasuhiko Sakai, Toshiyuki Hayase, Takashi Kubo

Nihon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japan Society of Mechanical Engineers, Part B　75　(752)　642-649　2009
Publisher: Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.75.752_642 　

ISSN： 0387-5016
NUMERICAL EXPERIMENT OF MR-MEASUREMENT-INTEGRATED SIMULATION OF STEADY BLOOD FLOW IN A CEREBRAL ANEURYSM Peer-reviewed

Kenichi Funamoto, Yoshitsugu Suzuki, Toshiyuki Hayase, Takashi Kosugi, Haruo Isoda

PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE 2008, PTS A AND B　1089-1090　2009
REPRODUCTION OF BLOOD FLOW FIELD BY NUMERICAL SIMULATION INTEGRATED WITH ULTRASONIC MEASUREMENT WITH NOISE Peer-reviewed

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2009, PT A AND B　455-456　2009
Reproduction of Pulse Waveform Measurement using One-dimensional Mathematical Model for Validation of Pulse Diagnosis

Tsutomu Nakanishi, Atsushi Shirai, Toshiyuki Hayase

Proceedings of GPBE/NUS-Tohoku Graduate Student Conference in Bioengineering　9-10　2008/12
Anisotropic Hybrid Blood Vessel Model using Poly (Vinyl Alcohol) Hydro Gel and Mesh Material

Lei Liu, Hiroyuki Kosukegawa, Makoto Ohta, Toshiyuki Hayase

GPBE/NUS-Tohoku Graduate Student Conference in Bioengineering　19-20　2008/12
Development of Poly (Vinyl Alchol) Gel with in vivo Acoustic Properties

O. Yamashita, K. Funamoto, T. Hayase

Proceedings of GPBE/NUS-Tohoku Graduate Student Conference in Bioengineering　30-31　2008/12
Effect of Vertical Distribution of Shear Stress Generated by Flow or Centrifugal Force on Orientation of Cultured Endothelial Cell

Manabu Saito, Toshiyuki Hayase, Kousuke Inoue, Motohiro Takeda

GPBE/NUS-Tohoku Graduate Student Conference in Bioengineering　38-39　2008/12
Formulation of Linearized Error Dynamics Equation of Measurement-Integrated Simulation

Kentaro Imagawa, Toshiyuki Hayase

GPBE/NUS-Tohoku Graduate Student Conference in Bioengineering　36-37　2008/12
Measurement of Friction Characteristics of Neutrophils on MPC Polymer with the Inclined Centrifuge Microscope

Takashi Umimoto, Atsushi Shirai, Toshiyuki Hayase

GPBE/NUS-Tohoku Graduate Student Conference in Bioengineering　11-12　2008/12
Physics Data Mining for Three-Dimensional Unsteady Blood Flow Field in an Aneurysmal Aorta

S. Morizawa, K. Shimoyama, S. Obayashi, K. Funamoto, T. Hayase

Proceedings of the 8th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　74-75　2008/12
Reproduction of Three-Dimensional Flow with Karman Vortex Street by Integrating Flow Simulation and Pressure Measurement

Takayuki Yamagata, Toshiyuki Hayase

Proceedings of Eighth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　50-51　2008/12
Numerical simulation of distribution of neutrophils in a lattice alveolar capillary network Peer-reviewed

Atsushi Shirai, Toshiyuki Hayase

Respiratory Physiology & Neurobiology　doi:10.1016/j.resp.2008.1　1-11　2008/11
Eigenvalue Analysis for Error Dynamics of Measurement Integrated Simulation to Reproduce Real Flows

Kentaro Imagawa, Toshiyuki Hayase

61st Annual Meeting of the APS Division of Fluid Dynamics　2008/11
Measurement-Integrated Simulation of Three-Dimensional Flow Behind a Square Cylinder Using Pressure Measurement on the Cylinder

Takayuki Yamagata, Toshiyuki Hayase

Bulletin of the Americal Physical Society　53　(15)　36-37　2008/11
Direct numerical simulation of turbulent mixing in grid-generated turbulence Peer-reviewed

Kouji Nagata, Hiroki Suzuki, Yasuhiko Sakai, Toshiyuki Hayase, Takashi Kubo

PHYSICA SCRIPTA　T132　2008/10

DOI： 10.1088/0031-8949/2008/T132/014054 　

ISSN： 0031-8949
Frictional characteristics of erythrocytes on coated glass plates subject to inclined centrifugal forces Peer-reviewed

Takashi Kandori, Toshiyuki Hayase, Kousuke Inoue, Kenichi Funamoto, Takanori Takeno, Makoto Ohta, Motohiro Takeda, Atsushi Shirai

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME　130　(5)　051007-1-8　2008/10

DOI： 10.1115/1.2948420 　

ISSN： 0148-0731
Estimation of Unsteady Blood Flow Rate in Ultrasonic-Measurement-Integrated Simulation －Effect of Estimation Precision on Reproducibility of Blood Flow

Takayuki Yamagata, Toshiyuki Hayase

International Symposium on Nano-Biomedical Engineering, 7th International Symposium of 2007 Tohoku University Global COE Program “Global Nano-Biomedical Engineering Education and Research Network Centre　36-37　2008/10
Numerical experiment for Ultrasonic-Measurement-Integrated simulation of three-dimensional unsteady blood flow Peer-reviewed

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

ANNALS OF BIOMEDICAL ENGINEERING　36　(8)　1383-1397　2008/08

DOI： 10.1007/s10439-008-9519-7 　

ISSN： 0090-6964
圧力測定孔の動特性と波形復元（第１報，オリフィスモデルを用いた場合） Peer-reviewed

廣瀬圭, 飯村彧郎, 佐々木芳宏, 土岐仁, 早瀬敏幸, 林叡, 畑中浩

日本フルードパワーシステム学会論文集　39　(4)　1-6　2008/07
Publisher: The Japan Fluid Power System Society
DOI： 10.5739/jfps.39.61 　

ISSN： 1346-7719

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This paper proposes a restoration method for the pneumatic pressure signal distorted due to dynamics of a cavity-mounted pressure sensing system, in order to obtain the "correct" or true pressure waveform to be sensed directly at the measuring point. Restoration is performed in the time domain by computing the output waveform of the "inverse transfer function" for the sensing system whose input is the actual, distorted signal from the system. For a relatively short (or thin) hole, restoration is to evaluate the left-hand side of a second order nonlinear differential equation itself. The restored pressure signal form has excellent agreement with the directly measured original one over a wide range of signal frequencies and amplitudes, or, despite overshoot and delay to a step-like change of the pressure.
Effect of Feedback Data Rate in PIV Measurement-Integrated Simulation Peer-reviewed

Takayuki Yamagata, Toshiyuki Hayase, Hiroshi Higuchi

Journal of Fluid Science and Technology　3　(4)　477-487　2008/06
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jfst.3.477 　

ISSN： 1880-5558

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This paper deals with measurement-integrated (MI) simulation, which is based on the observer in dynamical system theory to obtain the exact and detailed information of real flows. In this study, we propose the MI simulation coupled with Particle Image Velocimetry (PIV) for a flow with the Karman vortex street behind a square cylinder at Reynolds number of 1200 based on the cylinder width. The validity of the PIV-MI simulation is first examined in two-dimensional numerical experiment. The effect of feedback data rate is investigated by changing the feedback frequency and the feedback area. Then effectiveness of the PIV-MI simulation is validated in experiment. As a result, the PIV-MI simulation with full feedback shows good agreement with the standard solution for both the mean velocity and the velocity fluctuation. From the viewpoint of the reduced feedback data rate, spatially limited feedback shows better results than temporarily limited feedback. It is also confirmed that the information around the cylinder is important to reproduce the wake behind the cylinder. In the result of the experimental validation, the PIV-MI simulation reproduces the experimentally obtained flow field, showing the same effect of the feedback in accordance with the numerical experiment.
Development of Material Close to Anatomy: Experimental Apparatus to Measure Acoustic Properties

O. Yamashita, K. Funamoto, T. Hayase

Proceedings of Tohoku-NUS Student Joint Symposium　6-7　2008/05
Measurement of Unsteady Aerodynamic Forces of 3D Flapping Wing in Hovering Flight : 2nd Report, Comparison Between Trapezoidal and Sinusoidal Flapping Motions Peer-reviewed

NAGAI Hiroto, ITO Takumi, MIURA Keita, HAYASE Toshiyuki, ISOGAI Koji

Transactions of the Japan Society of Mechanical Engineers B　74　(739)　536-544　2008/03/25
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.74.536 　

ISSN： 0387-5016

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An experimental study of the aerodynamic characteristics of 3-dimensional flapping wing in hovering flight is conducted. Lift and power are measured in water on a scaled flapping wing of bumblebee. Two types of flapping motion are employed. One is a trapezoidal type of flapping motion which consists of translational, reversal and rotational phases; the other is a sinusoidal type of flapping motion, in which a wing is rotating continuously. The results show that the trapezoidal type has higher efficiency than the sinusoidal type. The shorter rotational phase enhances a fluid force normal to the wing surface. However, the rotational phase during the flapping translational phase contributes the increase of power rather than that of lift. This is because the enhanced fluid force vector due to the rotational phase is directed to the stroke plane, which requires more flapping power. In order to attain higher efficiency in hovering flight, the rotational phase should be done during the reversal phase rather than the flapping translational phase.
Accuracy Verification of Ultrasonic Measurement for Ultrasonic-Measurement-Integrated Simulation Using Poly (vinyl alcohol) Hydrogel Straight Tube Phantom

Lei Liu, Toshiyuki Hayase, Makoto Ohta, Kosuke Inoue

5th International Symposium on Tohoku University Global COE Program Global Nano-Biomedical Engineering Education and research Network Centre　2008/03
Determination of Fine Structure of Blood Flows by Coupling Measurement and Simulation

Toshiyuki Hayase

5th International Symposium on Tohoku University Global COE Program Global Nano-Biomedical Engineering Education and research Network Centre　2008/03
Accuracy Verification of Ultrasonic Measurement for Ultrasonic-Measurement-Integrated Simulation Using Poly (vinyl alcohol) Hydrogel Straight Tube Phantom

Lei Liu, Toshiyuki Hayase, Makoto Ohta, Kosuke Inoue

5th International Symposium on Global COE Program Global Nano-Biomedical Engineering Education and Research Network Centre　103-106　2008/03
Numerical Evaluation of Ultrasonic-Measurement-Integrated Simulation of Blood Flow

K. Funamoto, T. Hayase, Y. Saijo, T. Yambe

Proceedings of the 5th International Bio-Fluid Symposium and Workshop　116-117　2008/03
Experimental Study of Flow Oscillation Phenomenon in Right-Angle Branch with Double Side Branch Peer-reviewed

是松大樹, 奈良橋英樹, 生井智章, 藤井亀, 早瀬敏幸, 山口隆平

Transactions of the Japan Society of Mechanical Engineers (B), in Japanese　74　(738)　280-285　2008/02

DOI： 10.1299/kikaib.74.280 　
Reproduction of the Unsteady Pressure Field of Karman Vortex Street Behind a Square Cylinder by Hybrid Wind Tunnel Peer-reviewed

Takayuki Yamagata, Hikaru Shibata, Toshiyuki Hayase, Kasper Smit

Transactions of the Japan Society of Mechanical Engineers (B), in Japanese　74　(738)　362-369　2008/02
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.74.362 　

ISSN： 0387-5016

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This paper deals with the hybrid wind tunnel which combines wind tunnel experiment and numerical simulation to obtain the exact and detailed information of real flows. The hybrid wind tunnel, which is based on the observer theory, utilizes partial pressure measurement of a real flow for the numerical simulation. The measured pressure is included by the simulation through a feedback loop to overcome the difficulty of specifying exact boundary or initial conditions as well as the effect of modeling error. In this paper, the reproducibility of a pressure field on the hybrid wind tunnel, which treats a fundamental flow with the Karman vortex street behind a square cylinder, is investigated by comparison with pressure measurement on the side wall of the wind tunnel. As compared with ordinary simulation, mean pressure and pressure fluctuation reproduced by the hybrid wind tunnel agree well with that of experiment with large time steps which are inappropriate for ordinary simulations. Especially, the oscillation of the pressure synchronizes with that of experiment at -4D≦x≦3D (D: cylinder width) on the side wall of the wind tunnel, showing positive correlation with the experiment. The reduction of computational cost by using large time steps enables the hybrid wind tunnel to perform real time analysis of real flows.
Examples of Collaborative Japan- U.S. Fluids Information Triad Research Invited

Hiroshi Higuchi, Toshiyuki Hayase

46th AIAA Aerospace Sciences Meeting and Exhibition　2008/01/09
フラクタル格子乱流による乱流熱輸送の直接数値計算

鈴木博貴, 長田孝二, 酒井康彦, 早瀬敏幸, 久保貴

化学工学会研究発表講演要旨集　2008　577-577　2008
Publisher: 公益社団法人化学工学会
DOI： 10.11491/scej.2008f.0.577.0 　
フラクタル格子乱流の直接数値シミュレーション

鈴木博貴, 長田孝二, 酒井康彦, 早瀬敏幸, 久保貴

化学工学会研究発表講演要旨集　2008　5-5　2008
Publisher: 公益社団法人化学工学会
DOI： 10.11491/scej.2008.0.5.0 　
Measurement of unsteady aerodynamic force of 3d flapping wing in hovering to forward flight

Hiroto Nagai, Koji Isogai, Toshiyuki Hayase

ICAS Secretariat - 26th Congress of International Council of the Aeronautical Sciences 2008, ICAS 2008　5　800-810　2008
Direct numerical simulation of turbulent mixing in grid-generated turbulence Peer-reviewed

Kouji Nagata, Hiroki Suzuki, Yasuhiko Sakai, Toshiyuki Hayase, Takashi Kubo

Physica Scripta T　T132　2008

DOI： 10.1088/0031-8949/2008/T132/014054 　

ISSN： 0281-1847
Development of One-Dimensional Mathematical Model for Validation of Pulse Diagnosis Peer-reviewed

Kentaro Narumi, Tsutomu Nakanishi, Atsushi shirai, Toshiyuki Hayase

Transactions of the Japan Society of Mechanical Engineers (B)　74　(737)　142-148　2008/01

DOI： 10.1299/kikaib.74.142 　
Examples of Collaborative Japan- U.S. Fluids Information Triad Research (Invited) Invited

Hiroshi Higuchi, Toshiyuki Hayase

46th AIAA Aerospace Sciences Meeting and Exhibit　1-9　2008/01
Measurements of Dynamic Viscoelasticity of Poly (vinyl alcohol) Hydrogel for the Development of Blood Vessel Biomodeling Peer-reviewed

Hiroyuki KOSUKEGAWA, Keisuke MAMADA, Kanju KUROKI, Lei LIU, Kosuke INOUE, Toshiyuki HAYASE, Makoto OHTA

Journal of Fluid Science and Technology　3　(4)　533-543　2008/01
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jfst.3.533 　

ISSN： 1880-5558

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In vitro blood vessel biomodeling with realistic mechanical properties and geometrical structures is helpful for training in surgical procedures, especial those used in endovascular treatment. Poly (vinyl alcohol) hydrogel (PVA-H), which is made of Poly (vinyl alcohol) (PVA) and water, may be useful as a material for blood vessel biomodeling due to its low surface friction resistance and good transparency. In order to simulate the mechanical properties of blood vessels, measurements of mechanical properties of PVA-H were carried out with a dynamic mechanical analyzer, and the storage modulus (G') and loss modulus (G") of PVA-H were obtained. PVA-Hs were prepared by the low-temperature crystallization method. They were made of PVA with various concentrations (C) and degrees of polymerization (DP), and made by blending two kinds of PVA having different DP or saponification values (SV). The G' and G" of PVA-H increased, as the C or DP of PVA increased, or as the proportion of PVA with higher DP or SV increased. These results indicate that it is possible to obtain PVA-H with desirable dynamic viscoelasticity. Furthermore, it is suggested that PVA-H is stable in the temperature range of 0°C to 40°C, indicating that biomodeling made of PVA-H should be available at 37°C, the physiological temperature. The dynamic viscoelasticity of PVA-H obtained was similar to that of the dog blood vessel measured in previous reports. In conclusion, PVA-H is suggested to be useful as a material of blood vessel biomodeling.
Numerical Experiment for Ultrasonic-Measurement-Integrated Simulation of Developed Laminar Pipe Flow Using Axisymmetric Model Peer-reviewed

Lei Liu, Kenichi Funamoto, Toshiyuki Hayase

Journal of Biomechanical Science and Engineering　3　(2)　101-115　2008

DOI： 10.1299/jbse.3.101 　

ISSN： 1880-9863
Experimental Validation of Color Doppler Velocity Measurement for Ultrasonic-Measurement-Integrated Simulation of Blood Flow Peer-reviewed

Lei Liu, Toshiyuki Hayase, Makoto Ohta, Kosuke Inoue

Journal of Biomechanical Science and Engineering　3　(2)　161-175　2008

DOI： 10.1299/jbse.3.161 　

ISSN： 1880-9863
Measurement of Unsteady Aerodynamic Forces of 3D Flapping Wing in Hovering Flight : 1st Report, Influences of Reynolds Number, Reduced Frequency and Planform Peer-reviewed

NAGAI Hiroto, ITO Takumi, MIURA Keita, HAYASE Toshiyuki, ISOGAI Koji

Transactions of the Japan Society of Mechanical Engineers B　73　(736)　2450-2458　2007/12/25
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.73.2450 　

ISSN： 0387-5016

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An experimental study of the aerodynamic characteristics of 3-dimensional flapping wing in hovering flight is conducted in the wide range of parameters, which are Reynolds number, reduced frequency and wing planforms. Lift and power are measured on scaled flapping wings, which mimic bumblebee and cicada wings, and which are delta wings with different locations of maximum chord. The results show that lift and power (1) are almost unchanged in Re=800-5 000, (2) increase as the reduced frequency increases, although the effeciency is constant, and (3) increase as the location of maximum chord moves from wing base to tip, although the effeciency decreases.
Measurement of Mechanical Properties of Poly (vinyl alcohol) Hyrdogel for Development of Blood Vessel Biomodeling Peer-reviewed

Hiroyuki KOSUKEGAWA, Keisuke MAMADA, kanju KUROKI, Lei LIU, Kosuke INOUE, Toshiyuki HAYASE, Makoto Ohta

Proceedings of The Seventh International Symposium on Advanced Fluid Information and The Fourth International Symposium on Transdisciplinary Fluid Integration　50-51　2007/12
Three-Dimensional Flow Simulation around a Deformed Red Blood Cell Moving on a Flat Plate

Yuki Okuyama, Toshiyuki Hayase, Kenichi Funamoto

Proceedings of the 7th International Symposium on Advanced Fluid Information and the 4th International Symposium on Transdisciplinary Fluid Integration (AFI/TFI-2007)　60-61　2007/12
Effects of Number of Feedback Points in PIV Measurement-Integrated Simulation

Takayuki Yamagata, Toshiyuki Hayase, Hiroshi Higuchi

Proceedings of The Seventh International Symposium on Advanced Fluid Information and The Fourth International Symposium on Transdisciplinary Fluid Integration　232-235　2007/12
Effect of Time Resolution of Measurement on Ultrasonic-Measurement-Integrated Simulation of Three-Dimensional Unsteady Blood Flow in an Aneurysmal Aorta

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

Proceedings of the 3rd Tohoku-NUS Joint Symposium on Nano-Biomedical Engineering in the East Asian-Pacific Rim Region　13-16　2007/12
Measurement of Unsteady Aerodynamic Forces on 3D Flapping Wing (Comparison between Rotational and Sinusoidal Flapping Motions)

Hiroto Nagai, Koji Isogai, Toshiyuki Hayase

JSASS-KSAS Joint International Symposium on Aerospace Engineering　284-287　2007/10
Overview of Nano-Biomechanics Group in Global Nano-Biomedical Engineering Network Centre Invited

Toshiyuki Hayase

2nd International Symposium on 2007 Tohoku University Global COE Program Global Nano-Biomedical Engineering Education and research Network Centre　13-16　2007/09
ナノバブルと高周波超音波による腫瘍内血管の三次元画像の構築(Construction of three-dimentional image of intratumoral vessel using high-frequency contrast-enhanced micro-ultrasound)

冨田典子, 堀江佐知子, 渡邊夕紀子, 船本健一, 早瀬敏幸, 大木宏介, 森川秀広, 小野栄夫, 森士朗, 小玉哲也

日本癌学会総会記事　66回　353-353　2007/08
Publisher: 日本癌学会
ISSN： 0546-0476
鍼灸所見の臨床的意義と客観化六部定位の脈診について脈波情報の客観化と脈診 Invited Peer-reviewed

丸山満也, 金野敏, 仁田新一, 高島充, 白石泰之, 山家智之, 関隆志, 荒井啓行, 太田信, 劉磊, 白井敦, 早瀬敏幸

全日本鍼灸学会雑誌　57　(2)　116-118　2007/05
Publisher: The Japan Society of Acupuncture and Moxibustion
DOI： 10.3777/jjsam.57.110 　

ISSN： 0285-9955

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The purpose of this symposium was to clarify clinical significance of the pulse diagnosis at the wrist used for detecting the function of various organs. Base of the literature survey and his personal experiences, the importance of reliability (reproducibility) test of the pulse diagnosis in blinded manner and necessity of clinical trials with "_??_"-specific intervention was proposed by Ogawa. A unique training program of the pulse diagnosis was introduced by Kido, and he also demonstrated a significant positive result of "_??_"-specific intervention determined by the pulse diagnosis procedure in his program and suggested the clinical significance of the pulse diagnosis. Detection of various changes in pulse waveforms at the wrist using pressure transducer was demonstrated by Maruyama, and he also suggested a possible progress of objectivity in pulse diagnosis by various sensors and biomedical devices in future. From circulatory physiological point of view, factors which may affect the pressure pulse wave at the wrist were explained with several examples of pathologic conditions by Chihara. He also suggested a possibility of reflection of general condition in the pressure pulse at the wrist although it might be partial one, and stressed the necessity of other information for the accurate diagnosis. In general discussion, it was pointed out that evidence of the pulse diagnosis was still limited, and further experimental approaches of the pulse diagnosis will be required.
Studies on Funstional Biomodeling of Cerebral Artery with Mechanical Properties using Poly (vinyl alcohole) Hydro-gel Peer-reviewed

Hiroyuki KOSUKEGAWA, Keisuke MAMADA, Lei LIU, Kanju KUROKI, Toshiyuki HAYASE, Makoto OHTA

The 4th International Intracranial Stent Meeting ICS07 PROGRAM&ABSTRACTS　39-40　2007/04
1122 Effect of Retention Time of Neutrophils in Pulmonary Capillary Network on Increase in Their Concentration in the Network

SHIRAI Atsushi, HAYASE Toshiyuki

The proceedings of the JSME annual meeting　2007　83-84　2007
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2007.6.0_83 　

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Neutrophils can be retained in pulmonary capillaries causing higher concentration than in systemic circulation, and it is thought to be due to the cells' low deformability in passing through narrow capillaries. The authors numerically simulated flow of neutrophils through a simple capillary network model taking into consideration the cells deformability. However, in the simulation, the concentration ratio of the cells between those in the network and those injected into the network was less than a half of the experimentally obtained value. Other possible factors for the long retention time are friction or plasma leak between the cells and the endothelium of the capillaries. In this paper, these effects were simply modeled to introduce into the simulation and their contribution to the increase in the concentration was numerically investigated. Consequently, it was found that the concentration ratio has an upper limit, and it increases only in the case large amount of plasma leak.
1310 Prototyping of Cooperative Visualization Environment and Its application to Transdisplinary Fluid Integration Research

FUJISHIRO Issei, TAKESHIMA Yuriko, HAYASE Toshiyuki

The proceedings of the JSME annual meeting　2007　175-176　2007
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2007.6.0_175 　

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In this paper, we present the prototype of a novel cooperative visualization environment, called VIDELICET (<VI>___-sualization <DE>___-sign and <LI>___-fe C__-yclE__- managemenT__-), and explore datasets from transdisciplinary fluid integration research to illustrate the effective usage of the system.
1518 Study of Fluid Oscillation in Right-Angle Branch with Double Side Branch

NARAHASHI Hideki, KOREMATSU Taiki, NAMAI Tomoaki, HAYASE Toshiyuki, YAMAGUCHI Ryuhei

The proceedings of the JSME annual meeting　2007　101-102　2007
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2007.7.0_101 　

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In the previous study, it was clarified in the right-angle branch with single side branch that the velocity periodically oscillates in the side branch, and the Strouhal number is independent of cross-sectional area ratio, the flow division ratio of main branch to side branch, and the Reynolds number. In the present study, the flow structure in the right angle branch with double side branch has been experimentally studied in laminar steady flow using laser Doppler anemometer and particle image velocimetry. Consequently, the velocity periodically also oscillates in both side branches, and the Strouhal number is independent of the Reynolds number although the Strouhal number in the downstream side branch is a little larger than that in the upstream side branch. It has been clarified that the flow oscillation in the right-angle branch is a characteristic phenomenon caused from the geometry of right-angle branch and the factor inducing oscillation would be high shear rate.
156 Measurement of Frictional Characteristics of Red Blood Cells Moving on the Plates Coated with DLC or MPC Polymer Using Inclined Centrifuge Microscope Peer-reviewed

KANDORI Takashi, INOUE Kousuke, HAYASE Toshiyuki, TAKAGI Toshiyuki, TAKENO Takanori, OHTA Makoto, TAKEDA Motohiro

The Proceedings of Conference of Tohoku Branch　2007　(0)　111-112　2007
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmeth.2007.42.111 　
161 Basic Study for Development of Numerical Model of the Pulse Diagnosis Peer-reviewed

NARUMI Kentarou, NITTA Shin-ichi, NAKANISHI Tsutomu, LIU Lei, SHIRAI Atsushi, HAYASE Toshiyuki, OHTA Makoto, KONNO Satoshi, KAWATA Hiroshi, MARUYAMA Mitsuya

The Proceedings of Conference of Tohoku Branch　2007　(0)　121-122　2007
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmeth.2007.42.121 　
Effect of neutrophils retention time in capillaries on increase in their concentration in a lattice capillary network model Peer-reviewed

Atsushi Shirai, Toshiyuki Hayase

PROCEEDING OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2007　431-432　2007
Experimental Validation of Ultrasonic-Measurement-Integrated Simulation for Blood Flow in Aorta Invited

Lei Liu, Kosuke Inoue, Toshiyuki Hayase, Makoto Ohta

Future Medical Engineering Based on Bionanotechnology　Eds. Esashi, M., Ishii, K., Oh　981-986　2007/01
Development of Ultrasonic-Measurement-Integrated Simulation System for Complex Blood Flows Invited

Takayuki Yamagata, Toshiyuki Hayase

Future Medical Engineering Based on Bionanotechnology　Eds. Esashi, M., Ishii, K., Oh　1045-1051　2007/01
Numerical simulation of flow for viscoelastic neutrophil models in a rectangular capillary network: Effects of capillary shape and cell stiffness on transit time Peer-reviewed

Atsushi Shirai, Ryo Fujita, Toshiyuki Hayase

Technology and Health Care　15　(2)　131-146　2007

ISSN： 0928-7329
Accuracy of Ultrasonic-Measurement-Integrated simulation for three-dimensional blood flow in aneurysmal aorta Peer-reviewed

K. Funamoto, T. Hayase, Y. Saijo, T. Yambe

FEDSM 2007: PROCEEDINGS OF THE 5TH JOINT ASME/JSME FLUIDS ENGINEERING SUMMER CONFERENCE, VOL 2, PTS A AND B　733-738　2007

DOI： 10.1115/FEDSM2007-37497 　
Effect of retention time of neutrophils in alveolar capillaries on increase in their concentration in the capillary network Peer-reviewed

A. Shirai, T. Hayase

FEDSM 2007: PROCEEDINGS OF THE 5TH JOINT ASME/JSME FLUIDS ENGINEERING SUMMER CONFERENCE, VOL 2, PTS A AND B　773-778　2007

DOI： 10.1115/FEDSM2007-37653 　
Fundamental numerical experiment for validation of ultrasonic-measurement-integrated simulation using straight tube model Peer-reviewed

L. Liu, T. Hayase

FEDSM 2007: PROCEEDINGS OF THE 5TH JOINT ASME/JSME FLUIDS ENGINEERING SUMMER CONFERENCE, VOL 2, PTS A AND B　739-742　2007

DOI： 10.1115/FEDSM2007-37559 　
Direct numerical simulation of turbulent boundary layer downstream of turbulence-generating grid Peer-reviewed

H. Suzuki, K. Nagata, Y. Sakai, T. Hayase, T. Kubo

FEDSM 2007: PROCEEDINGS OF THE 5TH JOINT ASME/JSME FLUIDS ENGINEERING SUMMER CONFERENCE, VOL 2, PTS A AND B　1407-1411　2007

DOI： 10.1115/FEDSM2007-37433 　
Application of Ultrasonic Measurement to PVA-H Tissue-mimicking phantom

Liu L, Inoue, K, Hayase, T, Ohta, M

The 2nd Tohoku-NUS Joint Symposium on the Future Nano-medicine and Bioengineering in the East Asian Region　97-98　2006/12
Fundamental Study ofUltrasonic-Mesurement-Integrated Simulation: Numerical Experimant and Experimantal Applicatin with PVA Straight Pipe Model Peer-reviewed

Lei LIU, Kosuke INOUE, Toshiyuki HAYASE, Makoto OHTA

Proceedings of the 6th International Symposium on Advanced Fluid Information,　53-54　2006/12
3次元PIVデータによる脳内速度分布の定量的解析

村上洋紀, 太田信, 早瀬敏幸, 加藤琢真, 小杉隆司, 礒田治夫

第22回に本能神経血管内治療学会　157　2006/11
Numerical simulation of noninvasive blood pressure measurement Peer-reviewed

Satoru Hayashi, Toshiyuki Hayase, Atsushi Shirai, Masaru Maruyama

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME　128　(5)　680-687　2006/10

DOI： 10.1115/1.2241592 　

ISSN： 0148-0731
Numerical simulation of 3-D deformation of a neutrophil in a rectangular microchannel

Atsushi SHIRAI, Sunao MASUDA, Toshiyuki HAYASE

Journal of Biomechanics (Abstract of the 5th World Congress of Biomechanics)　333-CD-ROM　2006/08
Improvement of Accuracy of Blood Flow Simulation by Integrating Measurement Using Ultrasonic Doppler Method

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

Proceedings of the 5th World Congress of Biomechanics　CD-ROM　2006/07
3-D Numerical Simulation of Flow of a Neutrophil for the Retention Time in a Moderate Constriction of a Rectangular Microchannel Peer-reviewed

Atsushi Shirai, Sunao Masuda, Toshiyuki Hayase

Proceedings of ASME 2006 Summer Bioengineering Conference (CD-ROM)　1-2　2006/06
Fundamental study of transient characteristics of ultrasonic-measurement-integrated simulaiton toward reproduction of unsteady blood flows Peer-reviewed

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

Proceedings of ASME 2006 Summer Bioengineering Conference(CD-ROM)　1-2　2006/06
Numerical study on variation of feedback methods in ultrasonic-measurement-integrated simulation of blood flow in the aneurysmal aorta Peer-reviewed

K Funamoto, T Hayase, Y Saijo, T Yambe

JSME INTERNATIONAL JOURNAL SERIES C-MECHANICAL SYSTEMS MACHINE ELEMENTS AND MANUFACTURING　49　(1)　144-155　2006/03

DOI： 10.1299/jsmec.49.144 　

ISSN： 1344-7653
634 Numerical Simulation of Flow of a Neutrophil through a Rectangular Microchannel : Effect of Cross-section size of the Channel on the Transit Time

SHIRAI Atsushi, MASUDA Sunao, HAYASE Toshiyuki

The proceedings of the JSME annual meeting　2006　189-190　2006
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2006.5.0_189 　

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Transit characteristics of neutrophils through narrow capillaries is the fundamental knowledge for the understanding of the behavior of the cells in immune system in lungs. Authors have developed a simple mathematical model to predict the transit time of the cell through a capillary segment considering the cell as a visco-elastic sphere and the segment as an axisymmetric moderate constriction in a straight pipe. However, the real capillaries do not have the perfect circle cross section, and thus, the cell has to deform three dimensionally in passing through it. In this paper, the capillary is considered to be a moderate constriction in a rectangular channel, and flow of the cell through the constriction is numerically investigated in terms of the transit time for some combinations of the minimum width of the constriction and height of the channel. The transit time is compared with the axisymmetric model to show the effect of cross section of the channel on the transit time.
637 Blood Flow Simulation Integrated with Ultrasonic Measurement : 6^<th> Report : Three-Dimensional Unsteady Blood Flow Simulation

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

The proceedings of the JSME annual meeting　2006　195-196　2006
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2006.5.0_195 　

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Development and progress of circulatory diseases are closely related to the hemodynamics in the blood vessel. However, detailed and accurate information of blood flow field has yet to be obtained due to the limitations both in measurement and numerical simulation. Hence, we have proposed the Ultrasonic-Measurement-Integrated (UMI) simulation. In this method, feedback signals derived from the difference between measured and computed Doppler velocities are fed back to the numerical simulation. The transient and steady characteristics of the UMI simulation have been revealed. In this paper, we performed the numerical experiment aiming at the reproduction of the three-dimensional unsteady flow field. As the result, the application of the feedback in the UMI simulation made the computational results converge and trace to the model of real blood flow.
3709 Experimental Analysis of Oscillation Phenomena in Right-Angled Branch with Double Side Branch

Korematsu Taiki, Narahashi Hideki, Hayase Toshiyuki, Yamaguchi Ryuhei

The proceedings of the JSME annual meeting　2006　45-46　2006
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2006.7.0_45 　

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The flow structure in the right-angled branch with double side branch has been experimentally studied in laminar steady flow with laser doppler anemometer and particle image velocimetry. In the study of the right-angled branch with single side branch, it was clarified that the velocity periodically oscillates in the side branch, and the Strouhal number is independent of cross-sectional area ratio, the flow division ratio of main branch to side branch, and the Reynolds number. Periodical oscillation appears in the separation shearing layer, and a factor of oscillation is high shear rate. In this study, the factor of oscillation phenomena was examined in right-angled branch with double side branch.
S-14 超音波による心臓・血管の中の流れの医工学的解析(特別企画II(要望演題5) 逆流性疾患・閉塞性疾患・拡張性疾患に対する治療戦略-管と流れと-,第43回日本小児外科学会総会)

西條芳文, 白石泰之, 関根一光, 山家智之, 田中元直, 田林晄一, 早瀬敏幸, 船本健一, 大槻茂雄, 菅原重生

日本小児外科学会雑誌　42　(3)　355-355　2006
Publisher: 特定非営利活動法人日本小児外科学会
DOI： 10.11164/jjsps.42.3_355_2 　
Numerical Simulation of Flow and Deformation of a Neutrophil Passing Through a Constriction in a Fine Capillary

Atsushi SHIRAI, Ryo FUJITA, Toshiyuki HAYASE

Reports of the Institute of Fluid Science, Tohoku University　18　2006

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Published in the Proc. 5th JSME-KSME Fluid Eng. Conf., (2002).
B108 Development and Experimental Validation of Mathematical Model for Acquisition of Information in Pulse Diagnosis

NARUMI Kentarou, SHIRAISHI Mitsuya, NITTA Shin-ichi, NAKANISHI Tsutomu, LIU Lei, INOUE Kosuke, SHIRAI Atsushi, HAYASE Toshiyuki, OHTA Makoto, KONNO Satoshi, KAWATA Hiroshi

The Proceedings of the JSME Conference on Frontiers in Bioengineering　2006　(0)　55-56　2006
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebiofro.2006.17.55 　

ISSN： 1348-2939
Blood Flow Simulation Coupled with Ultrasonic Measurement

Toshiyuki Hayase, Kenichi Funamoto

Proceedings of the 1st Japan Korea Student Workshop　2　2006
3次元泳動特性解析法を用いたらせん型磁気マイクロマシンの形状設計 Peer-reviewed

山崎彩, 仙道雅彦, 石山和志, 早瀬敏幸, 荒井賢一

日本機械学会論文集C　72　(723)　3555-3560　2006

DOI： 10.1299/kikaic.72.3555 　

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通研インポート200703
Mechanism of Periodical Fluid Oscillation Induced by Separating High Shear Rate Flow in Side Branch of Right-Angle Branch Peer-reviewed

Ryuhei Yamaguchi, Johji Shimane, Syuichi Saito, Norimichi Hiraoka, Hisashi Fujii, Toshiyuki Hayase

Transactions of the Japan Society of Mechanical Engineers　72　(713)　75-80　2006/01
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.72.75 　

ISSN： 0387-5016

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In the previous study, it has been clarified in the right-angle branch that the periodical oscillation flow is induced in the side branch and the Strouhal number based on the variables in the side branch is independent of the Reynolds number, the flow division ratio, and the radius of the side branch. This periodical oscillation appears along the boundary between two pairs of vortices with the opposite rotation at the cross section of the side branch across the separation flow. In the present study, another source of the periodical oscillation is experimentally clarified that the high shear rate flow is induced along the separation shearing layer between the separation flow of low velocity and the main flow with high velocity along the distal wall in the side branch since the high shear rate along this separation shearing layer is several times as large as that in the upstream trunk or in the downstream region of the side branch.
Numerical realization of blood flow in aneurysmal aorta by integrating measurement and simulation Invited

Toshiyuki Hayase, Kenichi Funamoto, Takayuki Yamagata, Lei Liu, Atsushi Shirai, Makoto Ohta, Kosuke Inoue, Yoshifumi Saijo, Tomoyuki Yambe

FUTURE MEDICAL ENGINEERING BASED ON BIONANOTECHNOLOGY, PROCEEDINGS　Eds. Esashi, M., Ishii, K., Oh　857-+　2006
Development of Ultrasonic-Measurement-Integrated Simulation System for Complex Blood flows

Takayuki Yamagata, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

Proceedings of the Fifth International Symposium of Advanced Fluid Information　61-62　2005/12
Effect of Ultrasound Probe Placement in Ultrasonic-Measurement-Integrated Simulation of Blood Flows Peer-reviewed

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

Proceedings of the 12th International Conference on Biomedical Engineering (ICBME 2005)　CD-ROM　1-4　2005/12
Moderate Constriction Model for Neutrophils Flow in Pulmonary Capillaries

Atsushi Shirai, Ryo Fujita, Toshiyuki Hayase

Proceedings of The 7th International Symposium on Future Medical Engineering based on Bio-nanotechnology (21st Century COE Program) in The 12th International Conference on Biomedical Engineering (ICBME2005)　60-61　2005/12
Adaptive Visualization of Measurement-Integrated Simulation of Karman Vortex Street Based on Critical Points

Yuriko Takeshima, Hikaru Shibata, Shigeo Takahashi, Issei Fujishiro, Toshiyuki Hayase

Proceedings of the Fifth International Symposium on Advanced Fluid information, AFI-2005　94-95　2005/12
Development of Fundamental Technologies with Use of In-Vitro and In-Silico Models for Endovascular Treatments

Makoto Ohta, Daniel A. Ruefenacht, Pedro Lylyk, Toshiyuki Hayase, Akira Takahashi

Proceedings of the Fifth International Symposium on Advanced Fluid information, AFI-2005　32-35　2005/12
Numerical Analysis of Effect of Cross-section of Microchannel on Transit Characteristics of a Neutrophil

Sunao Masuda, Atsushi Shirai, Toshiyuki Hayase

Proceedings of the Fifth International Symposium on Advanced Fluid Information, AFI-2005　64-65　2005/12
Transdisciplinary Methodology Integrating Measurement and Simulation in Application of Complex Biomedical Flows Invited

Toshiyuki Hayase, Kenichi Funamoto, Takayuki Yamagata, Lei Liu, Atsushi Shirai, Makoto Ohta, Kosuke Inoue, Yoshifumi Saijo, Tomoyuki Yambe

Proceedings of the Fifth International Symposium on Advanced Fluid information, AFI-2005　36-39　2005/12
Development of a functional vessel biomodelling with Poly (vinyl alcohol) Hydrogel for in-vitro simulation Peer-reviewed

Lei Liu, Kousuke Inoue, Toshiyuki Hayase, Akira Handa, Edouard Fonck, Fumio Asakura, Stephan G. Wetzel, German Abdo, Hasan Yilmaz, Karl-Olof. Lovblad, Luca Augsburger, Daniel A. Rüfenacht, Hiroo Iwata, Suong-Hyu Hyon, Sadami Tsutsumi

The 6th international symposium on future medical engineering based on Bio-nanotechnology (21st Century COE program)　31-32　2005/11/21
Effect of Feedback Domain in Ultrasonic-Measurement-Integrated Simulation on Reproduction of Blood Flow Field in an Aneurysmal Aorta

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

Proceedings of the 6th International Symposium on Future Medical Engineering based on Bio-nanotechnology　62-63　2005/11
Numerical Simulation for Spatial Distribution of Neutrophils in a Capillary Network

Atsushi Shirai, Toshiyuki Hayase

Proceedings of the 6th International Symposium on Future Medical Engineering based on Bio-nanotechnology　60-61　2005/11
Experimental Validation of Ultrasonic-Measurement-Integrated Simulation for Blood Flow in Aorta

Lei Liu, Kosuke Inoue, Toshiyuki Hayase, Makoto Ohta

Proceedings of Second International Symposium on Transdisciplinary Fluid Integration, TFI-2005　37　2005/10
Variation of wall shear stress and periodic oscillations induced in the right-angle branch during laminar steady flow Peer-reviewed

R Yamaguchi, T Mashima, H Amagai, H Fujii, T Hayase, K Tanishita

JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME　127　(5)　1013-1020　2005/09

DOI： 10.1115/1.1852480 　

ISSN： 0098-2202
Reproduction of Instantaneous Distributions of Turbulent Flow by Simulation Integrated with Measurement Invited

Toshiyuki Hayase, Kentaro Imagawa

Proceedings of Mechanical Engineering Congress, 2005, Japan (MECJ-05)　8　277　2005/09
Reproduction of Exact Turbulent Flow Structure Using Measurement-integrated Simulation Invited

Toshiyuki Hayase, Kentaro Imagawa

Conference Proceedings of 8th U.S. National Congress on Computational Mechanics　CD-ROM　1　2005/07
Development of In-vitro model of cerebral aneurysm by PVA

Makoto Ohta Lei Liu Toshiyuki, Hayase Akira, Handa DA Ruefenacht, Hiroo Iwata, Sadami Tsutsumi

Journal of Japanese Society od Biorheology　28　(s)　36-36　2005/06/30
Inclined Centrifuge Microscope For Measuring Frictional Characteristics Of Red Blood Cells Moving On Glass Plate In Plasma Peer-reviewed

Toshiyuki Hayase, Hidekatsu Sugiyama, Takayuki Yamagata, Kosuke Inoue, Atsushi Shirai, Motohiro Takeda

Proceedings of the 2005 Summer Bioengineering Conference　CD-ROM　1-2　2005/06
Three-Dimensional Numerical Analysis Of Plasma Flow Around A Neutrophil In A Microchannel Peer-reviewed

Atsushi Shirai, Sunao Masuda, Toshiyuki Hayase

Proceedings of the 2005 Summer Bioengineering Conference　CD-ROM　1-2　2005/06
Ultrasonic-Measurement-Integrated Simulation For Reproduction Of Three-Dimensional Blood Flow Field In The Aorta With Aneurysm Peer-reviewed

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

Proceedings of the 2005 Summer Bioengineering Conference　CD-ROM　1-2　2005/06
Fundamental study of ultrasonic-measurement-integrated simulation of real blood flow in the aorta Peer-reviewed

K Funamoto, T Hayase, A Shirai, Y Saijo, T Yambe

ANNALS OF BIOMEDICAL ENGINEERING　33　(4)　415-428　2005/04

DOI： 10.1007/s10439-005-2495-2 　

ISSN： 0090-6964
Effect of Density of Monitoring Points for Feedback in Ultrasonic-Measurement-Integrated Simulation of Blood Flow in the Aorta with Aneurysm Peer-reviewed

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

Proceedings of the Third IASTED International Conference on Biomedical Engineering (BioMED 2005)　118-123　2005/02/17
Flow Simulation of Neutrophils in Capillary Network (Effect of Capillary Geometry on Transit Time of Cells Through Network) Peer-reviewed

Atsushi Shirai, Ryo Fujita, Toshiyuki Hayase

Proceedings of the Third IASTED International Conference on Biomedical Engineering (BioMED 2005)　284-289　2005/02/17
Numerical realization for analysis of real flows by integrating computation and measurement Peer-reviewed

T Hayase, K Nisugi, A Shirai

INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS　47　(6-7)　543-559　2005/02

DOI： 10.1002/fld.829 　

ISSN： 0271-2091
Measurement-Integrated Simulation for Numerical Realization of Complex Bio-Fluid Systems Invited

Toshiyuki Hayase, Kenichi Funamoto, Atsushi Shirai

The Second International Symposium on Intelligent Artifacts and Bio-systems, 2nd INABIO　65　2005/01/28
Stability of partly pressurized collapsible tube

Satoru Hayashi, Toshiyuki Hayase, Atsushi Shirai, Masaru Maruyama

Proceedings of the 2005 Summer Bioengineering Conference　2005　179-180　2005
1108 Blood Flow Simulation Integrated with Ultrasonic Measurement : 4^<th> Report: Improvement of Accuracy of Computational Hemodynamics

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

The proceedings of the JSME annual meeting　2005　89-90　2005
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2005.5.0_89 　

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Hemodynamics plays an important role in the development, progress and rupture of aneurysms, and therefore, is essential for advanced diagnosis. However, existing methodologies have yet to provide detailed and accurate information of blood flow field due to their individual limitations. As a solution to the problem, we have proposed Ultrasonic-Measurement-Integrated (UMI) simulation. In this method, feedback signals derived from the difference between measured Doppler velocity and the calculated one by numerical simulation are fed back to the numerical simulation. In this paper, we validate the efficacy of three-dimensional UMI simulation by the numerical analysis with various irradiation methods of ultrasonic beam. As the result, UMI simulation improves computational accuracy and enables us to obtain more accurate information of blood flow field including wall shear stress.
1265 Numerical Analysis of Effect of Cross-Sectional Configuration of Channel on Transit Characteristics of a Neutrophil

MASUDA Sunao, SHIRAI Atsushi, HAYASE Toshiyuki

The proceedings of the JSME annual meeting　2005　141-142　2005
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2005.6.0_141 　

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Neutrophils retain in pulmonary capillaries causing 40- to 80-fold higher concentration than in systemic large vessels even in normal lungs. The highly concentrated neutrophils are effectively recruited to inflammations for the host defense. Tube-flow model and Sheet-flow model are well known in the investigation of blood flow in pulmonary capillaries. Cross-sectional configuration of Tube-flow model is circle, but that of Sheet-flow model is rectangular. In the previous research, flow of neutrophil in an axisymmetric capillary model was investigated. In this research, three-dimensional deformation of a neutrophil and flow of plasma in a rectangular model are simulated to investigate effects of the difference in cross-sectional configuration. The neutrophil is largely deformed in the direction of X- and Y-axes. There are clearances between corners of the channel and the cell during the cell is in the channel, and pressure acting on the cell decreases due to plasma leak through the clearances.
321 Real-Time Analysis of Kalman Vortex Street Using Hybrid Wind Tunnel

SHIBATA Hikaru, HAYASE Toshiyuki

The proceedings of the JSME annual meeting　2005　11-12　2005
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2005.7.0_11 　

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It is difficult to obtain accurate and complete information of real flows by either numerical analysis or experimental measurement. Especially, determination of the pressure field in real flows is critically difficult problem. Hybrid wind tunnel integrating the numerical simulation and the measurement is possible solution to this problem, but has been investigated as off-line analysis tool. In this paper, we improved the hybrid wind tunnel system to obtain the accurate pressure, and to perform the real-time analysis. Karman vortex street behind a square cylinder was investigated with new system. Comparison between the measurement and the analysis for the pressure at feed back point shows good agreement.
211 Improvement of Flow Channels in Observation System for Blood Cells in a Micro-Channel

MASUDA Sunao, SHIRAI Atsushi, HAYASE Toshiyuki

Proceedings of the JSME Bioengineering Conference and Seminar　2004　59-60　2005
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebs.2004.17.0_59 　
212 Flow Simulation of Neutrophils in Capillary Network : Effect of Capillary Geometry on Transit Time of Cells Passing Through Network

SHIRAI Atsushi, FUJITA Ryo, HAYASE Toshiyuki

Proceedings of the JSME Bioengineering Conference and Seminar　2004　61-62　2005
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebs.2004.17.0_61 　
410 Study of Three-dimensional Feedback Law for Ultrasonic-Measurement-Integrated Simulation of Blood Flow in the Aorta

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

Proceedings of the JSME Bioengineering Conference and Seminar　2004　151-152　2005
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebs.2004.17.0_151 　
345 Design of Spiral Magnetic Micro-machine with Three-Dimensional Analysis of Swimming Properties

Yamazaki A., Sendoh M., Ishiyama K., Hayase T., Arai K. I.

Proceedings of the JSME Bioengineering Conference and Seminar　2004　337-338　2005
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebs.2004.17.0_337 　
Detection and correction of aliasing in ultrasonic measurement of blood flows with Ultrasonic-Measurement-Integrated simulation Peer-reviewed

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

Technology and Health Care　13　(4)　331-344　2005

ISSN： 0928-7329
Simulation model for flow of neutrophils in pulmonary capillary network Peer-reviewed

Atsushi Shirai, Ryo Fujita, Toshiyuki Hayase

Technology and Health Care　13　(4)　301-311　2005

ISSN： 0928-7329
Active control of Laminar boundary layer using various wall motions Peer-reviewed

J Qiu, T Hayase, T Okutani

CMC-COMPUTERS MATERIALS & CONTINUA　1　(4)　301-308　2004/12

ISSN： 1546-2218
Ultorasonic-Measurement-Integrated Simulation of Blood Flow in the Aorta with an Aneurysm

Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

Proceedings of The Fourth International Symposium on Advanced Fluid Information and The First International Symposium on Transdisciplinary Fluid Intergration AFI/TFI2004　1　(1)　16-21　2004/11
Numerical Realization of Flow with Karman Vortex Street Behind a Square Cylinder

Toshiyuki Hayase, Hikaru Shibata

Proceedings of The Fourth International Symposium on Advanced Fluid Information and The First International Symposium on Transdisciplinary Fluid Intergration AFI/TFI2004　1　(1)　356-357　2004/11
Effect of Cell Stiffnes on Transit Through Pulmonary Capillary Network

Atsushi Shirai, Ryo Fujita, Toshiyuki Hayase

Proceedings of The Fourth International Symposium on Advanced Fluid Information and The First International Symposium on Transdisciplinary Fluid Intergration AFI/TFI2004　1　(1)　26-29　2004/11
完全埋込を目指した人工心室補助装置の血行力学的影響慢性動物実験における心収縮補助効果の検討 Peer-reviewed

白石泰之, 山家智之, 岡本英治, 関根一光, 小川大祐, ポール・オレガリオ, 吉澤誠, 青木秀宜, 永利潤, 伊藤慎二, 田中明, 佐藤文博, 西條芳文, 王慶田, 圓山重直, 早瀬敏幸, 松木英敏, 本間大, 梅津光生, 仁田新一

人工臓器　33　(2)　S193-S193　2004/09
Fundamental study of aerodynamic drag reduction for vehicle with feedback flow control Peer-reviewed

K Nisugi, T Hayase, A Shirai

JSME INTERNATIONAL JOURNAL SERIES B-FLUIDS AND THERMAL ENGINEERING　47　(3)　584-592　2004/08

DOI： 10.1299/jsmeb.47.584 　

ISSN： 1340-8054
Fundamental study of hybrid wind tunnel integrating numerical simulation and experiment in analysis of flow field Peer-reviewed

K Nisugi, T Hayase, A Shirai

JSME INTERNATIONAL JOURNAL SERIES B-FLUIDS AND THERMAL ENGINEERING　47　(3)　593-604　2004/08

DOI： 10.1299/jsmeb.47.593 　

ISSN： 1340-8054
Development of Measurement System of Blood Cell Velocities in Microchannels

Sunao Masuda, Atsushi Shirai, Toshiyuki Hayase

Frontiers of Medical Infomatics, The 4th International Simposium on Future Medical Engineering based on Bio-nanotechnology(21st Century COE Program)　88-89　2004/06
Microscopic Observation of Red Blood Cells Moving on Glass Plate under Inclined Centrifugal Force

Kotomi Saito, Takayuki Yamagata, Toshiyuki Hayase, Atsushi Shirai, Kosuke Inoue, Motohiro Takeda

Frontiers of Medical Infomatics, The 4th International Simposium on Future Medical Engineering based on Bio-nanotechnology(21st Century COE Program)　2004　86-87　2004/06
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2004.5.0_51 　

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Precise frictional characteristics of the red blood cells (RBCs) have not been understood. Hayase et al. developed the inclined centrifuge microscope, and the frictional characteristics of RBCs on a glass plate were measured at the first step. In that research, it was the subject of discussion whether the cells glide or roll on the glass plate since the resolution of the microscope was not sufficient to distinguish the cell motion. This report deals with improvement of the observation technique for cell motion. At first, the magnification of the inclined centrifuge microscope is increased by 5 times. The shape of RBCs under movement can be seen clearly and cells seem to glide on the glass plate. However, it is still difficult to exclude the possibility of cell rolling. So authors investigated microbeads as the indicator of cell motion. It revealed that ordinary microbeads are too small to observe, and they don't adhere to RBCs.
Application of Ultrasonic-Measurement-Integrated Simulation to Blood Flow

Kenichi Funamoto, Toshiyuki Hayase, Atsushi Shirai, Yoshifumi Saijo, Tomoyuki Yambe

Frontiers of Medical Infomatics, The 4th International Simposium on Future Medical Engineering based on Bio-nanotechnology(21st Century COE Program)　78-79　2004/06
Flow Simuration of Neutrophils in Pulmonary Capillary Network

Atsushi Shirai, Ryou Fujita, Toshiyuki Hayase

Frontiers of Medical Infomatics, The 4th International Simposium on Future Medical Engineering based on Bio-nanotechnology(21st Century COE Program)　28-29　2004/06
Numerical Calculation of Species Transport in Poroelastic Media with Application to Perfusion in Brain Tissue

Joshua H. Smith, Joseph A. C. Humphrey, Toshiyuki Hayase

Frontiers of Medical Infomatics, The 4th International Simposium on Future Medical Engineering based on Bio-nanotechnology(21st Century COE Program)　76-77　2004/06
形状記憶合金アクチュエータを応用した人工食道開発 Peer-reviewed

山家智之, 堀, 義生, 渡辺, 誠, 白石泰之, 井口篤志, 田林胱一, 芳賀洋一, 江刺正喜, 吉澤誠, 田中, 明, 松木英敏, 佐藤文博, 川野恭之, 羅雲, 高木敏行, 早瀬敏幸, 圓山重直, 仁田新一, 佐々田比呂志, 佐藤英明, 宮田剛, 里見, 進, 本間, 大, 前田剛

日本AEM学会誌　12　(2)　94-99　2004/03
Flow Simulation of Neutrophil in Micro Capillary Network

SHIRAI Atsushi, FUJITA Ryo, HAYASE Toshiyuki

The proceedings of the JSME annual meeting　2004　45-46　2004
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2004.5.0_45 　

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Neutrophils are known as the most popular cells in leukocytes. They retain in pulmonary capillaries even in normal lungs causing 40- to 80-fold higher concentration than in systemic large vessels. The highly concentrated neutrophils are recruited to inflammations for the host defense. Therefore, it is essential to know their flow characteristics in the pulmonary capillary bed for the understanding of the immune system in lungs. For that purpose, authors have investigated the flow of a neutrophil in single capillary segment, and developed a mathematical model to simulate the flow of neutrophils in a capillary network. In this research, effect of the cell stiffness on the distribution of transit time of the cells is investigated. The result shows that the median of the transit times is longer than the average value for all the three levels of cell stiffness.
Fundamental Study on Optimum Design of Cardiac Motion Supporting Device

HANZAWA Toru, HAYASE Toshiyuki

The proceedings of the JSME annual meeting　2004　55-56　2004
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2004.5.0_55 　

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The principle of heart massager is applied to develop a new implantable cardiac supporting device that pushes the heart from outside to enhance the blood circulation only when it is needed. In order to use this devise clinically, this study aims to establish the methodology of the optimum design of its geometry and operating condition through numerical simulatioa As the first step, present report deals with development of the lumped parameter model of the systemic cycle of the cardiac system. Numerical solution was obtained with standard Runge-Kutta method. The solution qualitatively describes the dynamic characteristics of the system including essential information for the optimum design of the supporting devise, such as the power consumption and the energy of the cardiac motion. Furthermore, simulation was performed for a disabled heart to understand the effect of the parameter of the heart on the total blood flow.
Basic Study of Ultrasonic-Measurement-Integrated Simulation System

YAMAGATA Takayuki, Funamoto Kenichi, HAYASE Toshiyuki

The proceedings of the JSME annual meeting　2004　57-58　2004
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2004.5.0_57 　

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Detailed information of the velocity and pressure field of the blood flow is essential to establish an advanced diagnosis and treatment of serious circulatory diseases. Commonly used medical measurement equipments cannot measure such information, while even state-of-the-art numerical simulation cannot reproduce real blood flow accurately. In order to overcome this problem, the authors have proposed a new technique, Ultrasonic-Measurement-Integrated (UMI) simulation, that integrates ultrasonic measurement equipment and numerical, simulation, and revealed its usefulness by numerical simulation. The present report describes the development of fundamental procedure of the interface between ultrasonic equipment and simulation, and acceleration of computational speed for real time operation. By considering the tolerance of the solution, computational speed has been accelerated by a factor of 90 achieving only ten times longer computational time than real phenomena.
Development of Observation System for Blood Cells in Micro-Channel

MASUDA Sunao, SHIRAI Atsushi, HAYASE Toshiyuki

The proceedings of the JSME annual meeting　2004　49-50　2004
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2004.5.0_49 　

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Neutrophils retain in pulmonary capillaries causing 40- to 80-fold higher concentration than in systemic large vessels in normal lungs. The highly concentrated neutrophils are effectively recruited to inflammations for the host defense. Therefore, it is important to know the flow characteristics of neutrophils in pulmonary capillary bed for the understanding of the immune system in lungs. In previous studies, flow of a neutrophil through a narrow capillary was investigated numerically to develop a mathematical model. It is indispensable to evaluate the accuracy of the model. In this research, an observation system of flow of blood cells in microchannels is constructed, and the cell velocities are measured. Neutrophils don't pass through the channel under the pressure control. Erythrocytes pass through it under the flow rate control, and their velocities are measured to show that the velocity profile along their loci varies with the cell orientation entering the channel.
Experimental Analysis of Oscillation in Side Branch at Right-Angle Branch

SHIMANE Johji, KUDO Susumu, HAYASE Toshiyuki, YAMAGUCHI Ryuhei

The proceedings of the JSME annual meeting　2004　79-80　2004
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2004.7.0_79 　

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The flow structure in the right-angle branch has been experimentally studied in laminar steady flow with laser Doppler anemometry and particle image velocimetry. In the previous study, it was clarified that the velocity periodically oscillates in the side branch, and the Strouhal number is independent of cross-sectional area ratio, the flow division ratio of main branch-to-side branch, and the Reynolds number. The mechanism has not clarified adequately. There is another possibility that high shear rate is one of the factors inducing the periodical oscillation in side branch from a result of the velocity oscillation along the separation shearing layer from the entrance of side branch.
Analysis of Blood Flow in Aorta with Ultrasonic-Measurement-Integrated Simulation

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

The proceedings of the JSME annual meeting　2004　39-40　2004
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2004.7.0_39 　

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In order to reproduce the blood velocity and pressure fields of the blood flow for an accurate diagnosis or treatment for serious circulatory diseases such as aortic aneurysms, we are developing a new analysis methodology, namely Ultrasonic-Measurement-Integrated (UMI) simulation, by integrating color Doppler ultrasonography and numerical simulation. In the UMI simulation, feedback signals are added to the governing equations to compensate for the difference between computation and measurement. In this paper, we perform UMI simulation for the blood flow in descending aorta with an aneurysm. It is revealed that the UMI simulation reproduces the complicated blood flow structure and detects the incorrect measurement data.
Two-dimensional computational flow analysis and frictional characteristics model for red blood cell under inclined centrifuge microscopy Peer-reviewed

K Funamoto, T Hayase, A Shirai

JSME INTERNATIONAL JOURNAL SERIES C-MECHANICAL SYSTEMS MACHINE ELEMENTS AND MANUFACTURING　46　(4)　1304-1311　2003/12

DOI： 10.1299/jsmec.46.1304 　

ISSN： 1344-7653
Transit characteristics of a neutrophil passing through two moderate constrictions in a cylindrical capillary vessel - (Effect of cell deformation on transit through the second constriction) Peer-reviewed

A Shirai, R Fujita, T Hayase

JSME INTERNATIONAL JOURNAL SERIES C-MECHANICAL SYSTEMS MACHINE ELEMENTS AND MANUFACTURING　46　(4)　1198-1207　2003/12

DOI： 10.1299/jsmec.46.1198 　

ISSN： 1344-7653
Numerical Analysis for Affect of Neutrophil Shape on Transit Through Capillaries

A. SHIRAI, R. FUJITA, T. HAYASE

JSME International Journal, Series C　41-42　2003/11
Transit characteristics of a deformed neutrophil through a moderate constriction

Atsushi Shirai, Ryo Fujita, Toshiyuki Hayase

2003 ASME International Mechanical Engineering Congress　1　1-2　2003/11
One-Dimensional Finite Element Analysis of Poroelastic Media with Application to Perfusion in Brain Tissue

Joshua H. Smith, Joseph A. C. Humphrey, Toshiyuki Hayase

Third International Symposium on Advanced Fluid Information, AFI-2003　43-44　2003/11
Biomedical and Environmental Researches in Transdisciplinary Fluid Integration (TFI) Research Center

Takuma Kato, Toshiyuki Hayase, Yasuyuki Kohama

Third International Symposium on Advanced Fluid Information, AFI-2003　71-72　2003/11
Reproduction of Real Blood Flow in Aorta with Ultrasonic-Measurement-Integrated Simulation

Kenichi Funamoto, Toshiyuki Hayase, Atsushi Shirai, Tomoyuki Yambe, Yoshifumi Saijo

Third International Symposium on Advanced Fluid Information, AFI-2003, Fluid-Informatics for Biomedical and Environmental Quality Applications　39-40　2003/11
機械式人工心筋の開発心補助効果と生体心臓との力学的相互作用の基礎検討 Peer-reviewed

白石泰之, 岡本英治, 山家智之, 段旭東, 王慶田, 柴田宗一, 田中明, 小川大祐, 吉澤誠, 西條芳文, 仁田新一, 青木秀宜, 永利潤, 川合潤子, 末弘淳一, 吉田敬, 梅津光生, 井口篤志, 田林晄一, 圓山重直, 早瀬敏幸

人工臓器　32　(2)　S149-S149　2003/09
Fabrication of micropump with spiral-type magnetic micromachine Peer-reviewed

A Yamazaki, M Sendoh, K Ishiyama, KI Arai, T Hayase

IEEE TRANSACTIONS ON MAGNETICS　39　(5)　3289-3291　2003/09

DOI： 10.1109/TMAG.2003.816748 　

ISSN： 0018-9464
PARTIALLY PRESSURIZED COLLAPSIBLE TUBE MODEL

Satoru Hayashi, Masaru Maruyama, Toshiyuki Hayase, Atsushi Shirai

Proceedings of 7th Triennial International Symposium on Fluid Control, Measurement and Visualization (FLUCOME '03)　2003/08

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Three-dimensional analysis of swimming properties of a spiral-type magnetic micro-machine Peer-reviewed

A Yamazaki, M Sendoh, K Ishiyama, T Hayase, KI Arai

SENSORS AND ACTUATORS A-PHYSICAL　105　(1)　103-108　2003/06

DOI： 10.1016/S0924-4247(03)00069-4 　

ISSN： 0924-4247
Drag Reduction of Large-Size Vehicle by Feedback Flow Control

IWAFUNE Kensuke, HAYASE Toshiyuki, SHIRAI Atsushi

The proceedings of the JSME annual meeting　2003　201-202　2003
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2003.6.0_201 　

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Drag reduction of vehicles is an important problem concerned with energy saving and the environment protection. Especially in the commercial transportation field, it benefits significant saving in the fuel cost. Aerodynamic drag reduction has been conducted by designing body shape, but commercial vehicles have restrictions in it to keep the loading capacity. Therefore, other method for the drag reduction is desired. This report deals with the drag reduction of a large-size vehicle using feedback control. For the first step, effect of the location of control point on the drag reduction is investigated numerically.
Characteristics of a deformed neutrophil through a moderate constriction Peer-reviewed

A Shirai, R Fujita, T Hayase

2003 ADVANCES IN BIOENGINEERING　133-134　2003
Evidence-based Simulation of Blood Flow with Feedback of Ultrasonic Measurement

Toshiyuki Hayase, Kenichi Funamoto, Atsushi Shirai, Tomoyuki Yambe, Yoshifumi Saijo

The 1st International Symposium on Future Medical Engineering based on Bio-nanotechnology　40-42　2003/01
Transit characteristics of a neutrophil passing through a circular constriction in a cylindrical capillary vessel (effect of mechanical properties of the cell and constriction geometry) Peer-reviewed

A Shirai, R Fujita, T Hayase

JSME INTERNATIONAL JOURNAL SERIES C-MECHANICAL SYSTEMS MACHINE ELEMENTS AND MANUFACTURING　45　(4)　974-980　2002/12

DOI： 10.1299/jsmec.45.974 　

ISSN： 1344-7653
Numerical Realization of Flow by Integrating Computation and Measurement in Medical Applications Invited

Toshiyuki Hayase, Kenichi Funamoto, Keisuke Nisugi, Atsushi Shirai, Tomoyuki Yambe, Yoshifumi Saijo

Proceedings of Mini-Symposium on Advanced Fluid Information: Fusion of EFD and CFD　77-85　2002/12
Flow and Deformation of a Neutrophil Passing Through a Constriction in a Fine Capillary Peer-reviewed

Atsushi Shirai, Ryo Fujita, Toshiyuki Hayase

The Fifth JSME-KSME Fluids Engineering Conference　CD-ROM　(02-207)　187-192　2002/11
Effect of Column Separation on Self-Excited Osciliations in a Direct-Acting Poppet Valve Circuit Peer-reviewed

Satoru Hayashi, Weimin Wang, Toshiyuki Hayase

Proceedings of The 5th JFPS International Symposium on Fluid Power, NARA 2002　3　(5)　781-786　2002/11
Publisher: The Japan Fluid Power System Society
DOI： 10.5739/isfp.2002.781 　

ISSN： 2185-6303

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In this paper, the authors have shown that amplitudes of self-excited oscillations occurring in a poppet valve circuit are significantly affected by oil column separation. The numerical simulation has indicated that the magnitude of amplitude of self-excited oscillations is reduced into half in the large amplitude region by the effect of oil column separation.
Fundamental Consideration on Numerical Analysis of Unsteady Flow Through Spool Valve Peer-reviewed

Toshiyuki Hayase, Yupeng Xia, Atsushi Shirai, Satoru Hayashi

Proceedings of The 5th JFPS International Symposium on Fluid Power, NARA 2002　3　(5)　929-934　2002/11
Publisher: The Japan Fluid Power System Society
DOI： 10.5739/isfp.2002.929 　

ISSN： 2185-6303

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The present paper deals with the numerical analysis on unsteady flow through a spool valve. Especially the effect of the spatial and temporal grid resolutions on the computational results is investigated. For the valve model of a simple geometry, unsteady fow was calculated for the step change of the supply pressure. Variations of the fow rate and the fow force were obtained for several values of the grid resolution and the time step. Comparison of the results revealed the complex convergence process of the relevant flow analysis. The transient response corresponding to the flow rate change does not much depend on spatial grid resolution and the time step. After the transition, the fow force is strongly affected by the time step, and its convergence with the grid refinement is rather slow, while the fow rate is not sensitive to the time step and converges with a relatively rough spatial grid resolution.
Analysis of Dynamic Characteristics of Water hydraulic Relief Valve Peer-reviewed

Satoru HAYASHI, Takayuki NAKANISHI, Toshiyuki HAYASE, Atsushi SHIRAI

JOURNAL OF THE JAPAN FLUID POWER SYSTEM SOCIETY　33　(7)　149-155　2002/11

DOI： 10.5739/jfps.33.149 　
EFFECT OF CONSTRICTION GEOMETRY ON TRANSIT OF DEFORMABLE NEUTROPHILS IN CAPILLARIES

Atsushi Shirai, Ryo Fujita, Toshiyuki Hayase

Proceedings of IV World Congress of Biomechanics (WCB2002)　2002/08

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直径0.5mmの永動型磁気マイクロマシンの泳動特性解析 Peer-reviewed

山崎彩, 仙道雅彦, 石山和志, 早瀬敏幸, 荒井賢一

日本応用磁気学会誌　26　(4)　645-648　2002/08
Publisher: The Magnetics Society of Japan
DOI： 10.3379/jmsjmag.26.645 　

ISSN： 0285-0192

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The swimming properties of miniature magnetic micro-machines with spiral structures were analyzed theoretically employing a two-dimensional finite volume method. Based on the analysis results, a miniature machine was fabricated. The miniature machine was found to be able to swim in a fluid with Reynolds numbers of 10^-5 to 0.2. This result shows that the machine is suitable as a micro-size swimming machine. Good agreement was obtained between experimental and theoretical results. This method made it possible to design an optimum machine structure.
Numerical Realization of Flow Field by Integrating Computation and Measurement (Invited Paper) Invited

Toshiyuki Hayase, Keisuke Nisugi, Atsushi Shirai

Proceedings of Fifth World Congress on Computational Mechnics (WCCM V), July 7-12, (2002), Vienna, Austria　(Paper-ID: 81524)　1-12　2002/07
Hydraulic servo system with mechanically adjustable compliance Peer-reviewed

T Hayase, K Ishizawa, S Hayashi, Iimura, I

JOURNAL OF DYNAMIC SYSTEMS MEASUREMENT AND CONTROL-TRANSACTIONS OF THE ASME　124　(1)　168-175　2002/03

DOI： 10.1115/1.1433803 　

ISSN： 0022-0434
Suppression of T-S wave using wall motion actuator Peer-reviewed

JH Qiu, JJ Tani, T Hayase, M Suzuki

JSME INTERNATIONAL JOURNAL SERIES B-FLUIDS AND THERMAL ENGINEERING　45　(1)　29-34　2002/02

DOI： 10.1299/jsmeb.45.29 　

ISSN： 1340-8054
Numerical Simulation of Red Blood Cell under Inclined Centrifugal Force

FUNAMOTO Kenichi, HAYASE Toshiyuki, SHIRAI Atsushi

The proceedings of the JSME annual meeting　2002　97-98　2002
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2002.6.0_97 　

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Two dimensional flow analysis was performed to simulate the former experiment using the inclined centrifuge microscope for the frictional characteristics of red blood cells moving on a glass plate in a medium. Lift, drag and momentum acting on a red blood cell were obtained in various conditions. Considering a balance among various forces acting on a red blood cell, the frictional characteristics of a red blood cell were modeled as the sum of Coulomb friction and drag. The result indicates the possibility that a red blood cell deforms to expand on the front side, and the plasma layer of the thickness of 0.16 μm exists on a glass plate.
Wall Shear Stress and Periodical Oscillation in Side Branch in Right Angle Branch

Yamaguchi Ryuhei, Kudo Susumu, Amagai Hideaki, Hayase Toshiyuki

The proceedings of the JSME annual meeting　2002　83-84　2002
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2002.6.0_83 　

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In the present study, the wall shear stress and flow structure in the right angle branch have been studied experimentally in laminar steady flow using a laser Doppler velocimeter. The side branch, 14 mm in diameter, bifurcates at a right angle from the trunk, 24.5 mm in diameter, and both upstream and downstream corners at the entrance of the side branch are square edged. There is a periodical change of velocity in the side branch, and the Strouhal number based on the variables of the side branch is constant to be St_S=1.03. This phenomenon is a characteristic flow structure in the right angle branch.
Significant Improvement of Analysis Performance in Hybrid Wind Tunnel With Integration of Numerical Simulation and Experimental Measurement

NISUGI Keisuke, SHIRAI Atsushi, HAYASE Toshiyuki

The proceedings of the JSME annual meeting　2002　29-30　2002
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2002.7.0_29 　

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The new flow field analysis system of "Hybrid Wind Tunnel" is proposed. The basic idea of this facility is an integration of experimental measurement and computer simulation for general flow related problems. The problem treated in this work is well-known flow field as Karman Vortex Street in a wake of a column. The fundamental system components and first-step results are investigated in previous report. In the report, favorable results have been earned even if it used a course grid system. It is generally known that very-fine grid spacing and time increment are necessary for high-accurate numerical analysis. So it needs a huge calculation load. In this paper, the hybrid wind tunnel is compared to the ordinary numerical analysis with fine grid spacing and time increments in its analysis performance including accuracy and calculation time. As a result, calculation load is drastically decreased with valid accuracy.
Effect of Non-dimensional Mechanical Properties of a Neutrophil on the Transit Time Through a Moderate Constriction

SHIRAI Atsushi, BATHE Mark, FUJITA Ryo, HAYASE Toshiyuki

Proceedings of the JSME Bioengineering Conference and Seminar　2002　147-148　2002
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebs.2002.13.0_147 　
Three-dimensional flow analysis in VFP type artificial heart by unstructured grid

Satoyuki Kawano, Takuma Kato, Kazuhiro Nakahashi, Atsushi Shirai, Toshiyuki Hayase, Tomoyuki Yambe, Shin-Ichi Nitta, Hiroyuki Hashimoto

American Society of Mechanical Engineers, Pressure Vessels and Piping Division (Publication) PVP　448　(1)　229-238　2002

DOI： 10.1115/PVP2002-1556 　

ISSN： 0277-027X
Measurement of frictional characteristics of red blood cells moving on a plate in plasma due to inclined centrifugal force Peer-reviewed

Toshiyuki Hayase, Atsushi Shirai, Hidekatsu Sugiyama, Tsuyoshi Hamaya

Nippon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japan Society of Mechanical Engineers, Part B　68　(676)　3386-3391　2002
Publisher: Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.68.3386 　

ISSN： 0387-5016
The Effect of Neutrophil Activation on Transit Time through Pulmonary Capillaries

Atsushi Shirai, Mark Bathe, Toshiyuki Hayase

Proceedings of the First International Symposium on Advanced Fluid Information (AFI-2001)　125-130　2001/10
Suppression of T-S Wave Using Wall Motion Actuator

Jinhao Qiu, Junji Tani, Toshiyuki Hayase, Morio Suzuki

Proceedings of the First International Symposium on Advanced Fluid Information　169-174　2001/10
1B16 Flow of Neutrophils in Fine Capillaries with Constriction

SHIRAI Atsushi, FUJITA Ryo, HAYASE Toshiyuki

Proceedings of the JSME Bioengineering Conference and Seminar　2001　55-56　2001
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebs.2001.12.0_55 　
1B13 Mathematical Model of Red Blood Cell Moving on Glass Plate under the Influence of Centrifugal Force

HAYASE Toshiyuki, SUGIYAMA Hidekatsu, SHIRAI Atsushi, HAMAYA Tsuyoshi

Proceedings of the JSME Bioengineering Conference and Seminar　2001　49-50　2001
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebs.2001.12.0_49 　
Swimming of a Spiral-Type Magnetic Micro-Machine under Very Low Reynolds Number Conditions Peer-reviewed

Masahiko Sendou, Aya Yamazaki, Kazushi Ishiyama, Mituteru Inoue, Toshiyuki Hayase, Kenichi Arai

日本応用磁気学会誌　25　(4-2)　1223-1226　2001/01
Publisher: The Magnetics Society of Japan
DOI： 10.3379/jmsjmag.25.1223 　

ISSN： 0285-0192

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The swimming properties of a magnetic micro-machine with a spiral structure were examined experimentally and theoretically under very low Reynolds number conditions. It was demonstrated that the micro-machine could swim in a highly viscous fluid with a Reynolds number of 10^-7. This result suggests that the micro-machine has a great potential for medical applications. It was found that the optimum blade shape of the micro-machine varied with the Reynolds number condition.
Static and dynamic characteristics of a pressure-compensated flow control

S Hayashi, A Shirai, NN Guo, T Hayase

PROCEEDINGS OF THE FIFTH INTERNATIONAL CONFERENCE ON FLUID POWER TRANSMISSION AND CONTROL (ICFP'2001)　156-160　2001
Effect of initial axial strain of collapsible tube on self-excited oscillation Peer-reviewed

Y Xia, T Hayase, S Hayashi, T Hamaya

JSME INTERNATIONAL JOURNAL SERIES C-MECHANICAL SYSTEMS MACHINE ELEMENTS AND MANUFACTURING　43　(4)　882-888　2000/12

DOI： 10.1299/jsmec.43.882 　

ISSN： 1340-8062
Suppression of micro stick-slip vibrations in hydraulic servo-system Peer-reviewed

T Hayase, S Hayashi, K Kojima, Iimura, I

JOURNAL OF DYNAMIC SYSTEMS MEASUREMENT AND CONTROL-TRANSACTIONS OF THE ASME　122　(2)　249-256　2000/06

DOI： 10.1115/1.482450 　

ISSN： 0022-0434
Verification of One-Dimensional Models of Collapsible Tube Flow Based on Three-Dimensional Calculation of Tube Deformation Peer-reviewed

Yupeng Xia, Toshiyuki Hayase, Satoru Hayashi, Tsuyoshi Hamaya

Reports of the Institute of Fluid Science, Tohoku University　12　23-33　2000/04
Publisher:
Flow Structure and Fluid Oscillation in Right Angle Branch

TAKAYAMA Tsukasa, SUZUE Akihiro, SHIGETA Masaya, KUDO Susumu, YAMAGUCHI Ryuhei, HAYASE Toshiyuki

The proceedings of the JSME annual meeting　2000　931-932　2000
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2000.1.0_931 　

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In the present study the time variation of velocity and the distribution of wall shear stress in right angle branch have been experimentally studied in laminar steady flow by using a laser Doppler velocimeter. A side branch 8mm in diameter bifurcates from a trunk 24.5mm in diameter, and both upstream and downstream corners at the entrance of the side branch are square edge. The Strouhal number based on the variables in the side branch approximately is constant. In side branch, there are two symmetrical pairs of large vortices and small vortices. The fluid oscillation might be induced at the boundary between two vortices.
Development of magnetic micro-machine system for use in medical applications

ISHIYAMA Kazushi, SENDOH Masahiko, YABUKAMI Shin, YAMAZAKI Aya, YAMAGUCHI Masahiro, ARAI KenIchi, HAYASE Toshiyuki

The proceedings of the JSME annual meeting　2000　309-310　2000
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2000.1.0_309 　

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To develop micro-machines for use in medical application, two kinds of spiral-type magnetic micro-machine, which is driven by an external rotational magnetic field, were fabricated. These machines constructed by permanent magnets and spiral blade. It was demonstrated that changing the direction of the rotation planet of the external rotational field could control swimming direction of the swimming type magnetic micro-machine. The radius of the bend depended on the viscosity of the fluid and on the frequency of the external field. The another magnetic micro-machine could run in a gel and even in bovine meat. Running behavior of the machine depend on a frequency and strength of the external field. In addition, it can be detected where position of the magnetic micro-machine by a magnetic motion capture system.
Numerical Simulation of Flow in Right Angle Branch : Mechanism of Periodical Flow Oscillation in Side Branch

NAKAGAWA Tadashi, SHIRAI Atsushi, HAYASE Toshiyuki, HAYASHI Satoru, YAMAGUCHI Ryuhei

The proceedings of the JSME annual meeting　2000　257-258　2000
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2000.1.0_257 　

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This report deals with a numerical analysis on the stability of a flow in a right angle side branch. Spatial growth of velocity perturbation at the upstream boundary of the side branch is examined for various frequencies. The computational result revealed that frequency range of the maximum amplification coincides with that of the fluctuation observed in experiment. Distribution of the wall shear stress fluctuation due to instability shows the local extremum in both the proximal and the distal wall.
Fundamental Study on Hybrid Wind Tunnel : Analysis of Karman Vortex Street

HAYASE Toshiyuki, NISUGI Keisuke, SHIRAI Atsushi

The proceedings of the JSME annual meeting　2000　303-304　2000
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2000.4.0_303 　

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This report proposes a new concept of "Hybrid Wind Tunnel". The basic idea of this facility is an integration of experimental measurement and computer simulation for general flow related problems. A general structure of the equipment is first explained and a possible application for a simple unsteady flow problem is then discussed. The problem treated in this work is well-known flow field as Karman vortex street in a wake of a column. As the first step, a flow velocity component is estimated in off-line operation of the hybrid wind tunnel with feedback of the measurement pressure data on the column wall. Comparing the estimated data with measurement, the estimation performance of hybrid wind tunnel is investigated. As the results, even if its feedback scheme is tentative, it is shown that the estimated pressure and velocity is close to the measured one with its fluctuation and phase.
Feedback Control of Flow Field around the Vehicle : Effect of Control Parameters

NISUGI Keisuke, HAYASE Toshiyuki, SHIRAI Atsushi, HAYASHI Satoru

The proceedings of the JSME annual meeting　2000　301-302　2000
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2000.4.0_301 　

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This report deals with the numerical simulation of flow field around the vehicle with feedback control. In previous work, the flow field and vortex structure around the vehicle was investigated and effect of control port location was surveyed. The control law was composed of control parameters, such as the monitoring point location of the flow velocity output, the bias velocity, and the feedback gain. In this report, the effect of drag reduction and lift is surveyed for these parameters. As the result, lift is increased whenever the drag is reduced drastically in some parameter region. But using a simple front spoiler for the numerical model as aerodynamical device, the drag reduction keeps its effect while suppression the lift increase.
Measurement of Frictional Characteristics of a Red Blood Cell

SAKASHITA Shigeto, HAYASE Toshiyuki, SHIRAI Atsushi, HAMAYA Tsuyoshi

Proceedings of the JSME Bioengineering Conference and Seminar　2000　43-44　2000
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebs.2000.11.0_43 　
Effect of initial axial strain of collapsible tube on self-excited oscillation Peer-reviewed

Yupeng Xia, Toshiyuki Hayase, Satoru Hayashi, Tsuyoshi Hamaya

JSME International Journal, Series C: Mechanical Systems, Machine Elements and Manufacturing　43　(4)　882-888　2000
Publisher: Japan Society of Mechanical Engineers
DOI： 10.1299/jsmec.43.882 　

ISSN： 1344-7653
Analysis of Swimming Properties and Design of Spiral-Type Magnetic Micromachine. Peer-reviewed

Masahiko Sendoh, Noriyuki Ajiro, Kazushi Ishiyama, Mitsuteru Inoue, Toshiyuki Hayase, Ken Ichi Arai

JRM　12　(2)　165-171　2000

DOI： 10.20965/jrm.2000.p0165 　
Numerical Analysis of Flow around the Main Valve of Hydraulic Damper and Effect of Axial Flow Force on Stability of the Damper Peer-reviewed

HAYASE Toshiyuki

Transactions of the Japan Hydraulics & Pneumatics Society　31　(1)　22-29　2000
Publisher:
DOI： 10.14888/jfps1998.31.22 　

ISSN： 1343-4616
Analysis of Swimming Properties and Design of the Spiral-Type MagneticMicro-Machine Peer-reviewed

HAYASE Toshiyuki

Journal of Robotics and Mechatronics　12　(2)　165-171　2000
Wall shear stress and periodical oscillation induced in side branch at right angle branch in laminar steady flow Peer-reviewed

Ryuhei Yamaguchi, Susumu Kudo, Masaya Shigeta, Toshiyuki Hayase

American Society of Mechanical Engineers, Fluids Engineering Division (Publication) FED　251　(11085)　845-850　2000

ISSN： 0888-8116
Aerodynamic Drag Reduction by Feedback Control of Flow Field Peer-reviewed

HAYASE Toshiyuki

Proceedings of Sixth Triennal International Simposium on Fluid Control, Measurement and Visualization　(60)　1-6　2000
Influence of Pipeline Friction on Chaotic Oscillations in a Direct-Acting Poppet Valve Circuit Peer-reviewed

HAYASE Toshiyuki

Transactions of the Japan Hydraulics & Pneumatics Society　31　(5)　123-131　2000
Publisher: The Japan Fluid Power System Society
DOI： 10.14888/jfps1998.31.123 　

ISSN： 1343-4616

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Poppet valve circuits are liable to be unstable and various kinds of oscillations induced. This paper deals with chaotic oscillations occurring in a direct-acting poppet valve circuit with a long pipeline on the basis of a distributed parameter model with average pipeline friction. Then, the influence of pipeline friction on chaotic oscillations was examined taking the pipeline length as a control parameter by using the method of numerical simulation. Simulation results are qualitatively in better agreement with experimental results than the case of a frictionless pipeline model.
Stability Analysis of Collapsible Tube Flow Peer-reviewed

HAYASE Toshiyuki

Proceedings of Sixth Triennal International Simposium on Fluid Control, Measurement and Visualization　(69)　1-6　2000
Numerical Analysis of Flow Oscillation in Right Angle Side Branch Peer-reviewed

HAYASE Toshiyuki

Proceedings of Symposium on Computational Fluid Science, SCFS 2000, Sendai　29-34　2000
Effect of Initial Tube Strain on Self-Excited Oscillation of Collapsible Tube Flow Peer-reviewed

HAYASE Toshiyuki

The 2000 International Mechanical Engineering Congress & Exposition, Orlando, USA　BED-48　117-118　2000
Effect of machine shape on swimming properties of the spiral-type magnetic micro-machine Peer-reviewed

M Sendoh, N Ajiro, K Ishiyama, M Inoue, KI Arai, T Hayase, J Akedo

IEEE TRANSACTIONS ON MAGNETICS　35　(5)　3688-3690　1999/09

DOI： 10.1109/20.800632 　

ISSN： 0018-9464
Dynamic characteristics of collapsible tube flow Peer-reviewed

S Hayashi, T Hayase, Y Miura, Iimura, I

JSME INTERNATIONAL JOURNAL SERIES C-MECHANICAL SYSTEMS MACHINE ELEMENTS AND MANUFACTURING　42　(3)　689-696　1999/09

DOI： 10.1299/jsmec.42.689 　

ISSN： 1344-7653
Monotonic convergence property of turbulent flow solution with central difference and QUICK schemes Peer-reviewed

T Hayase

JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME　121　(2)　351-358　1999/06

DOI： 10.1115/1.2822213 　

ISSN： 0098-2202
Stability of a direct-acting poppet valve circuit with a long pipeline

Satoru Hayashi, Weimin Wang, Toshiyuki Hayase, Atsushi Shirai

Proceedings of the 3rd International Symposium on Fluid Power Transmission and Control (ISFP'99)　7-12　1999
Vehicle Vibration Control using Hydraulic Semi-Active Damper (Study Based on Quarter-Car Model) Peer-reviewed

HAYASE Toshiyuki

Transactions of the Japan Hydraulics & Pneumatics Society　30　(1)　10-19　1999
Publisher:
DOI： 10.14888/jfps1998.30.10 　

ISSN： 1343-4616
Validity of One-Dimensional Models of Collapsible Tube Flow Based on Three-Dimensional Calculation of Tube Deformation Peer-reviewed

HAYASE Toshiyuki

Transactions of the Japan Society of Mechanical Engineers (B)　65　(630)　497-504　1999

DOI： 10.1299/kikaib.65.497 　
Periodical oscillation in side branch of right angle branch in laminar steady flow Peer-reviewed

Ryuhei Yamaguchi, Yasunori Takahashi, Susumu Kudo, Toshiyuki Hayase

Nihon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japan Society of Mechanical Engineers, Part B　65　(630)　559-565　1999

DOI： 10.1299/kikaib.65.559 　

ISSN： 0387-5016
Two-Dimensional Analysis of the Properties of Magnetic Micro-Machines by the Finite Volume Method Peer-reviewed

HAYASE Toshiyuki

日本応用磁気学会誌　23　(4)　1665-1668　1999
Publisher: The Magnetics Society of Japan
DOI： 10.3379/jmsjmag.23.1665 　

ISSN： 0285-0192

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The swimming properties of magnetic micro-machines with spiral structures were analyzed theoretically by employing the two-dimensional finite volume method. Good agreement between the experimental and theoretical results was obtained. It was demonstrated that the swimming properties of machines depend strongly on the operational environment, including the state of the flow field and machine structure. Thus, there exists an optimum machine structure corresponding to the operation environment, which can be determined from the present analytical results.
Local Stability of a Direct-Acting Poppet Valve Circuit with a Long Pipeline Peer-reviewed

HAYASE Toshiyuki

Transactions of the Japan Hydraulics & Pneumatics Society　30　(3)　67-74　1999

DOI： 10.14888/jfps1998.30.67 　
Eigenvalue Analysis of Direct-Acting Poppet Valve Circuit Peer-reviewed

HAYASE Toshiyuki

Transactions of the Japan Hydraulics & Pneumatics Society　30　(3)　75-80　1999

DOI： 10.14888/jfps1998.30.75 　
Flow visualization of right angle branch in laminar steady flow Peer-reviewed

Ryuhei Yamaguchi, Yasunori Takahashi, Susumu Kudo, Toshiyuki Hayase

Nihon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japan Society of Mechanical Engineers, Part B　65　(634)　1986-1991　1999

DOI： 10.1299/kikaib.65.1986 　

ISSN： 0387-5016
Chaotic Oscillations in a Direct-Acting Poppet Valve Circuit (Case of a Long Pipeline) Peer-reviewed

HAYASE Toshiyuki

Transactions of the Japan Hydraulics & Pneumatics Society　30　(5)　119-127　1999

DOI： 10.14888/jfps1998.30.119 　
Effect of Initial Axial Strain of Collapsible Tube on Self-Excited Oscillation Peer-reviewed

HAYASE Toshiyuki

Transactions of the Japan Society of Mechanical Engineers (B)　65　(638)　3352-3358　1999
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.65.3352 　

ISSN： 0387-5016

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In this paper an experiment was performed to investigate the dynamic characteristics of a collapsible tube flow. The effect of initial axial strain of the tube on the self-excited oscillation was studied by changing the initial stretch of a silicone rubber tube for various values of the flow rate. The frequency and the amplitude of pressure and flow rate oscillation at the upstream and the downstream ends were measured. The characteristics of the self-excited oscillation were strongly related to the initial strain in a range of lower flow rate and lower initial stretch. Three different types of oscillation were observed in the present condition. The type of the oscillation changes to the other one due to variation of the initial axial strain of the tube or the supply flow rate.
Eigenvalue Analysis of Direct-Acting Poppet Valve Circuit Peer-reviewed

HAYASE Toshiyuki

Proceedings of the Fourth JHPS International Symposium on Fluid Power　303　303-308　1999
Numerical Simulation of Water Hydraulic Relief Valve Peer-reviewed

HAYASE Toshiyuki

Proceedings of the Fourth JHPS International Symposium on Fluid Power　555-560　1999
Chaotic Oscillations in a Direct-Acting Poppet Valve Circuit (Pipeline Length as a Control Parameter) Peer-reviewed

HAYASE Toshiyuki

Proceedings of the Fourth JHPS International Symposium on Fluid Power　11　(1)　597-602　1999
Numerical analysis for stability and self-excited oscillation in collapsible tube flow Peer-reviewed

S Hayashi, T Hayase, H Kawamura

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME　120　(4)　468-475　1998/08

DOI： 10.1115/1.2798016 　

ISSN： 0148-0731
Nonlinear Control of Micro Stick-Slip Vibration in Hydraulic Servo Systems Peer-reviewed

HAYASE Toshiyuki

Transactions of Japan Society of Mechanical Engineers(C)　64　(619)　772-779　1998
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/kikaic.64.772 　

ISSN： 0387-5024

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This paper treats nonlinear control of a hydraulic servo system to suppress micro stick-slip vibrations. The system consists of a hydraulic cylinder, a servo-valve and a personal computer. Self-excited vibrations of two different types occur in the conventional feedback control system. Discontinuous control signal generated through a D/A converter causes a stick-slip vibration of micron order over the wide range of the feedback gain. Increasing the feedback gain results in the other type of stick-slip vibration of nearly ten times larger amplitude due to the locally increased flow gain in the underlap region of the servo-valve. The feedback linearization technique is applied to compensate the nonlinearity of the valve. Numerical simulation and experiment were performed for both the present nonlinear control system and the ordinary linear control system to confirm the validity of the former one in suppressing the micro stick-slip vibration. The other type of micro stick-slip vibration due to the D/A converter was effectively suppressed by improving the resolution of the input signal.
Numerical Analysis of Transient Flow through a Spool Valve(Modeling of Transient Characteristic in High Reynolds Number Flow) Peer-reviewed

HAYASE Toshiyuki

Transactions of Japan Society of Mechanical Engineers(B)　64　(619)　724-731　1998

DOI： 10.1299/kikaib.64.724 　
Dynamic Characteristics of Flow in Collapsible Tube Peer-reviewed

HAYASE Toshiyuki

Transactions of Japan Society of Mechanical Engineers(B)　64　(620)　1055-1062　1998

DOI： 10.1299/kikaib.64.1055 　
Hydraulic Servo System with Variable Compliance Peer-reviewed

HAYASE Toshiyuki

Transactions of Japan Society of Mechanical Engineers(C)　64　(621)　1588-1595　1998
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/kikaic.64.1588 　

ISSN： 0387-5024

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This paper describes a hydraulic servo system of variable compliance used in the environment of frequent machine-human interaction. Sufficient reliability is critical in such a circumstance, so a mechanical adjustment of compliance of the servo system is considered here. In the present system neutral position of the bridge valve circuit is controlled to adjust the compliance. Mathematical model of the system is derived to study the static and dynamic behavior of the system. In the operating condition with large compliance, the present system has a strong nonlinear characteristic, and the nonlinear control technique of feedback linearization was successfully applied. On the other hand, conventional linear control was applicable for the operating condition of small compliance. Validity of the present servo system was confirmed by experiment.
Study of Hydraulic Semi-Active Damper(2nd Report, Stability of the Damper) Peer-reviewed

HAYASE Toshiyuki

Transactions of the Japan Hydraulics and Pneumatics Society　29　(3)　66-73　1998

DOI： 10.14888/jfps1998.29.66 　
Feedback Control of Turbulent Flow Field Using State Observer Peer-reviewed

HAYASE Toshiyuki

Proceedings of 2nd Japan-France Seminar on Intelligent Materials and Structures　24-27　1998
Verification of One-Dimensional Collapsible Tube Models Based on Three-Dimensional Calculation of Tube Deformation Peer-reviewed

HAYASE Toshiyuki

Proceedings of the 5th Japan-USA-Singapore-China Conference on Biomechanics　82-83　1998
Numerical Analysis of Stochastic Red Blood Cell Motion in Capillaries Peer-reviewed

HAYASE Toshiyuki

Proceedings of the 5th Japan-USA-Singapore-China Conference on Biomechanics　40-41　1998
Numerical Analysis for Flow in Partly Pressurized Collapsible Tube Peer-reviewed

HAYASE Toshiyuki

Advances in Bioengineering, International Mechanical Engineering Congress & Exposition, ASME　39　55-56　1998
State estimator of flow as an integrated computational method with the feedback of online experimental measurement Peer-reviewed

T Hayase, S Hayashi

JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME　119　(4)　814-822　1997/12

DOI： 10.1115/1.2819503 　

ISSN： 0098-2202
Chaos in a hydraulic control valve Peer-reviewed

S Hayashi, T Hayase, T Kurahashi

JOURNAL OF FLUIDS AND STRUCTURES　11　(6)　693-716　1997/08

DOI： 10.1006/jfls.1997.0096 　

ISSN： 0889-9746
Numerical Analysis for Stability and Self-Excited Oscillation in Collapsible Tube Flow

Satoru Hayashi, Toshiyuki Hayase, Hiroshi Kawamura

Workshop on Biofluid and Mechanics, Sendai　1-11　1997/07
Dynamic Characteristics of Collapsible Tube Flow and Simulation of Korotkoff Sounds by Starling Resistor Peer-reviewed

Satoru Hayashi, Toshiyuki Hayase

The Memoirs of the Institute of Fluid Science, Tohoku University　8　63-70　1997/03
Publisher: Tohoku University
ISSN： 0916-2860
Micro Stick-Slip Vibration in Hydraulic Servo Systems Peer-reviewed

HAYASE Toshiyuki

Transactions of Japan Society of Mechanical Engineers(C)　63　(606)　444-450　1997
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/kikaic.63.444 　

ISSN： 0387-5024

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This report treats micro stick-slip vibrations occurring in a typical computer-controlled hydraulic servo system. The relevant system consists of a hydraulic cylinder, a servo valve and a personal computer. First, an experiment was performed for a conventional feedback control system to confirm the occurrence of two different types of stick-slip vibration of small amplitude. Detailed numerical analysis was then performed to identify the main factors contributing to the vibrations. The control signal generated by the D/A converter causes micro stick-slip vibration of small amplitude over a wide range of control feedback gain. Increasing the feedback gain results in another type of micro stick-slip vibration of large amplitude due to the locally increased flow gain within the underlap of the servo valve. Computational results agree well with the experimental ones.
Numerical Analysis of the Dynamic Characteristics of a Balanced Piston Type Relief Valve(1st Report, Numerical Simulation and Experimental Results) Peer-reviewed

HAYASE Toshiyuki

Journal of the Japan Hydraulics and Pneumatics Society　28　(2)　232-238　1997
Publisher: The Japan Fluid Power System Society
DOI： 10.5739/jfps1970.28.232 　

ISSN： 0286-6900

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In this paper, the authors have derived a mathematical model describing the dynamics of a balanced piston type relief valve, which is represented by 11 ordinary differential equations and 3 difference equations depicting the dynamics of a supply and load pipeline which are assumed to be as lossless distributed parameter elements. The validity of the model has been confirmed by comparing the simulated results with experimental results. Furthermore, influences of the system parameters on the dynamic characteristics of a relief valve have been investigated by simulation of the proposed model.
Numerical Analysis of the Dynamic Characteristics of a Balanced Piston Type Relief Valve(2nd Report, Stability of a Relief Valve) Peer-reviewed

HAYASE Toshiyuki

Journal of the Japan Hydraulics and Pneumatics Society　28　(2)　239-244　1997
Publisher: The Japan Fluid Power System Society
DOI： 10.5739/jfps1970.28.239 　

ISSN： 0286-6900

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In this paper, the authors have studied the stability of a balanced piston type relief valve on the basis of a mathematical model derived and confirmed to be valid qualitatively in the previous paper. It has been demonstrated that the stability of a relief valve can be easily analyzed by a method dividing the overall operating region into two parts by the cracking condition of the main valve. The analysis shows that the stability of a relief valve is subject to the stability of the pilot part.
Deformation of Red Blood Cells in Fine Capillaries Peer-reviewed

HAYASE Toshiyuki

Proceedings of the International Conference on New Frontiers in Biomechanical Engineering, Tokyo　399-402　1997
Study on Stability of Semi-Active Damper Peer-reviewed

HAYASE Toshiyuki

Proceedings of The Fifth International Symposium on Fluid Control, Measurement and Visualization, FLUCOME'97　2　651-656　1997
Numerical Analysis of Transient Flow through a Spool Valve(Modeling of Transient Characteristic in High Reynolds Number Flow) Peer-reviewed

HAYASE Toshiyuki

Proceedings of The Fifth International Symposium on Fluid Measurement, Control and Visualization, FLUCOME'97　1　379-384　1997
Numerical Simulation of Korotkoff Sounds Peer-reviewed

HAYASE Toshiyuki

Advances in Bioengineering, International Mechanical Engineering Congress & Exposition, ASME　36　93-94　1997
Analysis of Instability and Self-Excited Vibration for Collapsible Tube by Distributed Parameter Model Peer-reviewed

HAYASE Toshiyuki

Advances in Bioengineering, International Mechanical Engineering Congress & Exposition, ASME　36　105-106　1997
Numerical Analysis on Stability and Self-Excited Vibration in Collapsible Tube Peer-reviewed

HAYASE Toshiyuki

Transactions of Japan Society of Mechanical Engineers　62　(594)　556-563　1996

DOI： 10.1299/kikaib.62.556 　
Fundamental Study on Computer Aided Flow Field Control(State Ovserver for Flow System) Peer-reviewed

HAYASE Toshiyuki

Transactions of Japan Society of Mechanical Engineers　62　(598)　2261-2268　1996
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.62.2261 　

ISSN： 0387-5016

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This paper deals with a fundamental study on the control problem of distributed parameter and nonlinear flow fields using a high-performance supercomputer as a controller. A state observer is proposed as a basic element of the control system to estimate the complete state from th mathematical model and partial measurements. A SIMPLER-based flow simulation algorithm is used as the mathematical model of the system. The error of the numerical solution evaluated by comparison with the measurement is fed back to the mathematical model to reduce the discrepancy. The adoption of this feedback loop distinguishes the state observer from ordinary flow simulations. With this feedback loop the computational result may converge even for unstable flows with fluctuations. A numerical simulation has been performed for a turbulent flow through a square duct to confirm the validity of the present state observer. A real flow is simulated using a standard numerical solution of a developed turbulent flow. Appropriate choice of the proportional feedback gain accelerates the convergence in the simulation by a factor of 60 and reduces the error in estimating the perturbation velocity component by a factor of 0.5 in comparison with he ordinary flow simulation without a feedback loop.
State of the Art of Oil- and Water Hydraulic Control Technologies Peer-reviewed

HAYASE Toshiyuki

Journal of the Society of Instrument and Control Engineers　35　(2)　106-110　1996
Publisher: The Society of Instrument and Control Engineers
DOI： 10.11499/sicejl1962.35.106 　

ISSN： 0453-4662
Numerical Analysis of Response for Pulsatile Flow in Collapsible Tube under variable External Pressure(Simulation for Korotkoff Sounds) Peer-reviewed

HAYASE Toshiyuki

10th Conference of the European Society of Biomechanics Abstracts　22　1996
Chaotic Vibration in Direct Acting Poppet Valve Peer-reviewed

HAYASE Toshiyuki

19th International Congress of Theoretical and Applied Mechanics, Abstracts　113　1996
Transient Characteristics of Hydraulic Control Elements Peer-reviewed

HAYASE Toshiyuki

Turbo Machinery　24　(9)　540-546　1996
Publisher: Turbomachinery Society of Japan
DOI： 10.11458/tsj1973.24.540 　

ISSN： 0385-8839
Advanced Oil- and Water Hydraulic Control Technologies Peer-reviewed

HAYASE Toshiyuki

M&E　23　(10)　198-205　1996
Numerical Analysis for Stability of Balanced Piston Type Relief Valve Peer-reviewed

HAYASE Toshiyuki

Proceedings of 3rd JHPS International Symposium on Fluid Power, Yokohama　531-536　1996
Micro Sticks-Slip Vibration in Hydraulic Servo Systems Peer-reviewed

HAYASE Toshiyuki

Proceedings of 3rd JHPS International Symposium on Fluid Power, Yokohama　555-560　1996
Self-Excited Vibration Occurring in Pulsation Flow in Collapsible Tube

Satoru Hayashi, Toshiyuki Hayase, Akihito Koretsune

Advances in Bioengineering, International Mechanical Engineering Congress & Exposition, ASME　Vol. BED-31　207-208　1995/11
Fundamental Study on Computer Aided Flow Field Control

Toshiyuki Hayase, Satoru Hayashi

Proceedings of International Symposium on Microsystems, Intelligent Materials and Robots　386-389　1995/09
Chaos in a Hydraulic Control Valve

Satoru Hayashi, Toshiyuki Hayase, Tetsuo Kurahashi

Fluid-Structure Interaction and Structural Mechanics　PVP　(310)　109-115　1995/07
NUMERICAL-ANALYSIS OF TRANSIENT FLOW-THROUGH A PIPE ORIFICE - (TIME CONSTANT FOR SETTLING FLOW) Peer-reviewed

T HAYASE, P CHENG, S HAYASHI

JSME INTERNATIONAL JOURNAL SERIES B-FLUIDS AND THERMAL ENGINEERING　38　(2)　157-163　1995/05

DOI： 10.1299/jsmeb.38.157 　

ISSN： 0914-8817
Numerical Analysis of Transient Flow through a Spool Valve Peer-reviewed

Toshiyuki Hayase, Ping Cheng, Satoru Hayashi

The Reports of the Institute of Fluid Science　7　123-133　1995/03
Publisher: Tohoku University
ISSN： 0916-2879
Numerical Analysis of Transient Flow through Spool Valve Peer-reviewed

HAYASE Toshiyuki

Transactions of Japan Society of Mechanical Engineers　61　(584)　1382-1388　1995

DOI： 10.1299/kikaib.61.1382 　
Chaotic Vibration in Poppet Valve Circuit Peer-reviewed

HAYASE Toshiyuki

Transactions of Japan Society of Mechanical Engineers　61　(585)　18010-1815　1995
Comparison Between Discretization Schemes in Direct Numerical Simulation of Turbulent Flow Through a Square Pipe Peer-reviewed

HAYASE Toshiyuki

Transactions of Japan Society of Mechanical Engineers　61　(591)　3967-3974　1995
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.61.3967 　

ISSN： 0387-5016

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A direct numerical simulation has been conducted for turbulent flow through a square pipe. Turbulent flow solutions are obtained using the 2nd order accurate central difference scheme as well as Leonard's QUICK scheme for discretizing convective terms on three grid systems of different resolution. Comparison between the results has revealed that the QUICK scheme provides more accurate results with less computational effort than the central difference scheme. In the present condition, the solution for the QUICK scheme converges monotonically with increasing number of grid points, while the result for the central difference scheme shows rather complex behavior.
Mechanism of Hard Self-Excited Vibration in Pipe Value Circuit Peer-reviewed

Satoru Hayashi, Tetsuo Kurahashi, Toshiyuki Hayase

Proceedings of 4th Triennial International symposium on fluid Control, Measurement, and Visualization　641-646　1994/08
Nonlinear Control of Hydraulic Manipulator

Toshiyuki Hayase, Hiroshi Ishigami, Satoru Hayashi

Proceedings of 1st Asian Control Conference　2　565-568　1994/07
Numerical Analysis of Collapsible Tube Flow without Separation

Satoru Hayashi, Toshiyuki Hayase, Hiroshi Kawamura

Second World Congress of biomechanics Abstracts　2　263　1994/07
Numerical Analysis of Transient Flow through a Pipe Orifice Starting from Initial Steady flow Peer-reviewed

Toshiyuki Hayase, Ping Cheng, Satoru Hayashi

Proceedings of 3rd JSME-KSME Fluids Engineering Conference　277-282　1994/07
Strongly Nonlinear Hydraulic Manipulator Designed for Precise Motion Control

Toshiyuki Hayase, Hiroshi Ishigami, Satoru Hayashi

Proceedings of 3rd International Workshop on Advanced Motion Control　783-790　1994/03
Numerical Analysis of Transient Flow through a Pipe Orifice (2nd Report, Step Response from Initial steady Flow) Peer-reviewed

HAYASE Toshiyuki

Transactions of Japan Society of Mechanical Engineers　60　(569)　78-84　1994

DOI： 10.1299/kikaib.60.78 　
CONTROL OF A FLEXIBLE INVERTED PENDULUM Peer-reviewed

T HAYASE, Y SUEMATSU

ADVANCED ROBOTICS　8　(1)　1-12　1994

ISSN： 0169-1864
Numerical Treatment of Discontinuity due to Collision Peer-reviewed

HAYASE Toshiyuki

油圧と空気圧　25　(3)　439-445　1994

DOI： 10.5739/jfps1970.25.439 　
Basic Study on Loss torque of Rotating Polygon Mirror (1st Report, Numerical Analysis for Three-Dimensional Unsteady Flow) Peer-reviewed

HAYASE Toshiyuki

Transactions of Japan Society of Mechanical Engineers　60　(576)　2679-2683　1994
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/kikaic.60.2679 　

ISSN： 0387-5024

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A rotating polygon mirror is commonly used in contemporary printing devices. The understanding of the flow field around the rotating mirror is essential for analysis and design, since reduction of the hydrodynamic load torque directly leads to an improvement in the performance. In this paper, a numerical analysis has been conducted for the flow in the space between a fixed outer cylinder and a rotating octagonal inner cylinder. Discretized transport equations are solved for two-dimensional and three-dimensional time-dependent constant property flows using a second-order accurate finite volume scheme within the context of SIMPLER-based iterative methodology. Two-dimensional calculations show a shear-driven recirculating flow in cavity regions, while three-dimensional calculations reveal a distinct turbulent flow structure. The hydrodynamic loss torque is mainly due to an asymmetric pressure distribution on the polygon surface especially at high rotating speed. This result is qualitatively confirmed by a simple model experiment.
コラプシブルチューブに発生する自励振動(集中定数モデルによる検討) Peer-reviewed

HAYASE Toshiyuki

Transactions of Japan Society of Mechanical Engineers　60　(579)　3636-3641　1994

DOI： 10.1299/kikaib.60.3636 　
Piecewise-Linear Modeling of Hydraulic System for State-Feedback Control Strategy Peer-reviewed

Toshiyuki Hayase, Naoyuki Isozaki, Satoru Hayashi

Proceedings of the Second JHPS International Symposium on Fluid Power　1993　(2)　533-538　1993/09
Publisher: The Japan Fluid Power System Society
DOI： 10.5739/isfp.1993.533 　

ISSN： 2185-6303

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A piecewise linear model was developed for an electro-hydraulic servo system as a fundamental consideration for applying modern control theory to hydraulic control systems with strong nonlinearity. Comparison among the experimental result and numerical simulations based on the nonlinear and linear models has revealed the advantage of the piecewise linear model to the ordinary linear one. Then singular perturbation technique was applied to obtain a reduced order piecewise-linear model which is conveniently used for personal-computer controlled system design.
Numerical Analysis of Transient Flow through a Pipe Orifice: Time Constant for the Settling Flow Peer-reviewed

Toshiyuki Hayase, Ping Cheng, Satoru Hayashi

Proceedings of the Second JHPS International Symposium on Fluid Power　1993　(2)　671-676　1993/09
Publisher: The Japan Fluid Power System Society
DOI： 10.5739/isfp.1993.671 　

ISSN： 2185-6303

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As a fundamental consideration in hydraulic valve dynamics, transient flow through a pipe orifice has been studied via' a numerical analysis. Steady axisymmetric viscous fluid flow was first investigated to confirm the present SIMPLER based finite volume methodology. Time-dependent calculation for suddenly imposed pressure gradient has shown two distinct characteristic time constants for the transient state. The first characteristic time is commonly considered corresponding to the flow rate change, while the second one concerning to the variation of flow structure has not been treated in earlier studies. The final settling of the flow is established throughout the second characteristic time which is almost ten times larger than the first one for the present condition.
Control of a flexible inverted pendulum Peer-reviewed

Toshiyuki Hayase, Yoshikazu Suematsut

Advanced Robotics　8　(1)　1-12　1993

DOI： 10.1163/156855394X00013 　

ISSN： 1568-5535 0169-1864
Numerical Analysis of Transient Flow through a Pipe Orifice (1st Report, Time Constant for the Settling Flow) Peer-reviewed

HAYASE Toshiyuki

Transaction of JSME(B)　59　(560)　1023-1029　1993

DOI： 10.1299/kikaib.59.1023 　
Mechanism of Hard Self-Excited Vibration in Poppet Valve (1st Report, The Case of Large Valve Lift) Peer-reviewed

HAYASE Toshiyuki

Transection of JSME(C)　59　(563)　2020-2025　1993

DOI： 10.1299/kikaic.59.2020 　
Direct Numerical Simulation of Turbulent Flow in a Square Pipe Peer-reviewed

Toshiyuki Hayase, Yoshikazu Suematsu, Akio Kikuchi

Transactions of Japan Society of Mechanical Engineers　58　(546)　p364-370　1992/02
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.58.364 　

ISSN： 0387-5016

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A numerical analysis is conducted without introducing any turbulence model for the turbulent flow in a square pipe. The direct numerical calculation approach generally requires a huge computational time and memory size, and is possibly performed on a relatively coarse grid system. Therefore, evaluation of the solution for the coarse grid system is important in practical applications. Comparison with the experiment and the large eddy simulation (LES) reveals that the present calculation successfully predicts the characteristic feature of the turbulent flow even with the coarse grid system. Quantitative improvement of the solution is achieved nearly in proportion to the grid resolution squared.
Induced Flows and Torque Characteristics of a Slitted Disk Enclosed in a Cylinder(Numerical Analysis of Three Dimensional Flow) Peer-reviewed

HAYASE Toshiyuki

Transaction of JSME(B)　58　(550)　1674-1681　1992
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.58.1674 　

ISSN： 0387-5016

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Numerical calculations by a finite-difference method have been made for a steady three-dimensional flow induced by a rotating disk with radial slits enclosed in a cylinder, and the results were compared with those for the nonslitted condition. The main conclusions obtained from the calculations are summarized as follows: (1)Considerable radial flows are generated inside the slits of the disk, resulting in a flow pattern quite different from that induced by a disk without slits and an increase of the momentum exchange. (2)With the increase in the Reynolds number the torque transmitted to the slitted disk is increased more due to the angular momentum exchange compared with that of the nonslitted disk.
NUMERICAL STUDY OF 3-DIMENSIONAL FLOW AND HEAT-TRANSFER BETWEEN A FIXED OUTER CYLINDER AND A ROTATING INNER CYLINDER WITH CAVITIES Peer-reviewed

T HAYASE, JAC HUMPHREY, R GREIF

ROTATING MACHINERY : TRANSPORT PHENOMENA　239-254　1992
Numerical calculation of convective heat transfer between rotating coaxial cylinders with periodically embedded cavities Peer-reviewed

T. Hayase, J. A.C. Humphrey, R. Greif

Journal of Heat Transfer　114　(3)　589-597　1992

DOI： 10.1115/1.2911322 　

ISSN： 1528-8943 0022-1481
A CONSISTENTLY FORMULATED QUICK SCHEME FOR FAST AND STABLE CONVERGENCE USING FINITE-VOLUME ITERATIVE CALCULATION PROCEDURES Peer-reviewed

T HAYASE, JAC HUMPHREY, R GREIF

JOURNAL OF COMPUTATIONAL PHYSICS　98　(1)　108-118　1992/01

DOI： 10.1016/0021-9991(92)90177-Z 　

ISSN： 0021-9991
Direct Numerical Simulation of Turbulent Flow in a Square Pipe Peer-reviewed

Toshiyuki Hayase, Yoshikazu Suematsu

Proceedings of 3rd Triennial International Symposium on Fluid control, Measurement, and Visualization　99-106　1991/08
Numerical Calculation of Static Flow Characteristics of Collapsible Tube Peer-reviewed

Satoru Hayashi, Toshiyuki Honda, Toshiyuki Hayase

The Reports of the Institute of Fluid Science　3　201-206　1991/03
Control of Flexible Inverted Pendulum Peer-reviewed

HAYASE Toshiyuki

Journal of the Robotics Society of Japan　9　(2)　162-168　1991
Publisher: The Robotics Society of Japan
DOI： 10.7210/jrsj.9.162 　

ISSN： 0289-1824

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This study treats a particular control problem of an inverted pendulum with flexible structure. An inverted pendulum problem is a fundamental of stabilizing unstable systems such as a walking robot. Furthermore, consideration of the flexibility is essential for control of a light weight mechanical system with quick motion. A controlled system in this study consists of a wire-driven carrier, a flexible beam hinged to the carrier and a weight fixed at the other side of the beam. Linear quadratic control was applied to stabilize the system using a personal computer. However, steady vibration due to the coulomb friction was observed in the system. Characteristics of the nonlinear vibration were well explained by the analysis using the method of averaging. A simple recursive algorithm was employed to estimate the value of the Coulomb friction. With an on-line estimation and compensation of the Coulomb friction, linear quadratic control was successfully applied to stabilize, the system.
AN ADVANCED VISION SENSOR WITH FOVEA

Y SUEMATSU, T HAYASE

IECON 90, VOLS 1 AND 2　1　581-585　1990
DISTRIBUTION PATTERNS OF EIGENVALUES OF LAMINAR PIPE-FLOW - CLASSIFICATION OF MODES BASED ON DYNAMICS OF THE SYSTEM Peer-reviewed

T ITO, Y SUEMATSU, K HASE, T HAYASE

JSME INTERNATIONAL JOURNAL SERIES II-FLUIDS ENGINEERING HEAT TRANSFER POWER COMBUSTION THERMOPHYSICAL PROPERTIES　31　(4)　632-638　1988/11

DOI： 10.1299/jsmeb1988.31.4_632 　

ISSN： 0914-8817
Distribution Patterns of Eivenvalues of Laminar Pipe Flow 3rd Report, Effect of the Reynolds Number Peer-reviewed

末松良一, 早瀬敏幸, 長谷賢治, 伊藤忠哉

Transactions of Japan Society of Mechanical Engineers　54　(505)　2433-2440　1988/09
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.54.2433 　

ISSN： 0387-5016

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This study investigates the structure and dynamic behavior of a linear system which describes the perturbation of a laminar pipe flow. In the preceding papers a numerical method for calculating the eigenvalues with sufficient accuracy was proposed, and the characteristic distribution pattern of eigenvalues for Poiseuille pipe flow and the classification of the modes of the perturbations were presented. This paper discusses the effects of the Reynolds number on the distribution pattern of eigenvalues. In the first place, for the Poiseuille pipe flow, it is shown how the distribution of eigenvalues in a complex phase velocity plane takes a tree like shape as the Reynolds number increases. Then the distributions of eigenvalues are calculated for the laminar developing pipe flow and the Poiseuille pipe flow with rigid rotation, which are known to be unstable for high Reynolds number. It is found that these distribution patterns take the same shape as that of Poiseuille pipe flow, and that the unstable eigenvalues belong to the specified modes of perturbations, as predicted in the former report.
Numerical Method for Distribution of Eigenvalues in Laminar Pipe Flows

Tadaya Ito, Kenji Hase, YOshikazu Suematsu, Toshiyuki Hayase

Memories of the Factory Engineering, Nagoya University　40　(1)　121-134　1988/05
Distribution Patterns of Eigenvalues of Laminar Pipe Flow (1st Report, Determination of Approximate Subspace in the Galerkin Method) Peer-reviewed

伊藤忠哉, 長谷賢治, 末松良一, 早瀬敏幸

Transactions of Japan Society of Mechanical Engineers　53　(491)　1917-1924　1987/07
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.53.1917 　

ISSN： 0387-5016

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As the first step in clarifying the structure and dynamic behavior of a linear system which describes the perturbation of a parallel flow in a pipe, the distribution of the eigenvalues in the system in studied. For this purpose, first the formulation is made in a Hilbert space, which facilitates the geometrical interpretation of the problem. Then, by applying the Galerkin method, a finite dimensional approximate linear system is obtained. In the latter process, a difficulty arises as to how the order of the approximation is to be determined. To give an answer to this, a concrete measure is proposed using the concept of the operator invariance of the subspace. To examine the validity of the measure, the distribution of the eigenvalues of Poiseuille flow is calculated. It is found that the proposed measure is a dequate for obtaining the accurate distribution of the eigenvalues.
distribution Patterns of Eigenvalues of Laminar Pipe Flow (2nd Report, Classification of Modes Based on Dynamics of the System) Peer-reviewed

HAYASE Toshiyuki

Transactions of Japan Society of Mechanical Engineers　53　(495)　3227-3235　1987
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.53.3227 　

ISSN： 0387-5016

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This study aims to clarify the structure and dynamic behavior of the linear system which describes the small perturbation of a laminar pipe flow. In the preceding paper the eigenvalue problem was formulated for a Hilbert space, based on the spectrum theory. And a numerical method for calculating the eigenvalues was proposed, together with a measure of accuracy. Applying the proposed method, this paper discusses the distribution of eigenvalues and the mode of perturbations for the Poiseuille pipe flow. The wave perturbations for various azimuthal and axial wave numbers are investigated with a fixed Reynolds number. It is shown that the distribution of eigenvalues in a complex phase velocity plane has a tree like shape. The mode of perturbations is divided into three classes : slow, fast and mean modes by the axial phase velocity, or wall, center and neutral modes by the radial distribution of the magnitude of the eigenfunction. For each type of mode, the location of the corresponding eigenvalue in the complex phase velocity plane is clarified, and the dependence of the eigenvalue on the original linear dynamic system is also clarified by computer calculations.
VORTEX BREAKDOWN PHENOMENA IN A CIRCULAR PIPE .5. AXISYMMETRICAL BREAKDOWN IN ROTATING CONICAL PIPES Peer-reviewed

Y SUEMATSU, T ITO, T HAYASE

BULLETIN OF THE JSME-JAPAN SOCIETY OF MECHANICAL ENGINEERS　29　(258)　4122-4129　1986/12

ISSN： 0021-3764
VORTEX BREAKDOWN PHENOMENA IN A CIRCULAR PIPE .4. MECHANISM OF AXISYMMETRICAL BUBBLE TYPE BREAKDOWN Peer-reviewed

Y SUEMATSU, T HAYASE, T ITO

BULLETIN OF THE JSME-JAPAN SOCIETY OF MECHANICAL ENGINEERS　29　(253)　2086-2094　1986/07

ISSN： 0021-3764
Vortex Breakdown Phenomena in a Circular Pipe 5th Report, Axisymmetric Breakdown in Rotating Conical Pipes Peer-reviewed

末松良一, 伊藤忠哉, 早瀬敏幸

Transactions of Japan Society of Mechanical Engineers　52　(476)　1626-1633　1986/04
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.52.1626 　

ISSN： 0387-5016

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It is known that a swirling flow in a diverging pipe breaks down more easily than a flow in a converging one. In this report, experiments are made using diverging, converging and straight pipes, in order to clarify the relation between the shape of pipes and the occurrence of the breakdown. Swirling flow fields, that are realized by rotation of pipes, are measured by a Laser-Doppler-Velocimeter. When each pipe rotates faster than a certain critical value, a stationary internal wave occurs. The vortex breakdown phenomenon is due to the internal waves in swirling flows, as pointed out in preceding reports. In the diverging pipe, the amplitude of the wave is rather smaller than that in the converging pipe ; but the mean axial flow near the axial is fairly retarded, so that the flow reverses at the trough of the superposed wave component, and bubble type breakdown appears. A mathematical model is also presented to give a qualitative explanation of the effect of a sectional area variation.
GROWING PROCESS AND STRUCTURE OF AXISYMMETRICAL VORTEX BREAKDOWN .1. AN INVISCID LINEAR-MODEL OF THE GROWING PROCESS OF A BUBBLE Peer-reviewed

Y SUEMATSU, T ITO, T HAYASE, N KATO

BULLETIN OF THE JSME-JAPAN SOCIETY OF MECHANICAL ENGINEERS　29　(249)　773-780　1986/03

ISSN： 0021-3764
Vortex Breakdown Phenomena in a Circular Pipe 4th Report, Mechanism of Axisymmetric Bubble Type Breakdown in a Rotating Pipe Peer-reviewed

末松良一, 伊藤忠哉, 早瀬敏幸

Transactions of Japan Society of Mechanical Engineers　51　(471)　3488-3496　1985/11
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.51.3488 　

ISSN： 0387-5016
On the Vortex Breakdown Phenomena in a Swirling Pipe-Flow Peer-reviewed

Tadaya Ito, Yoshikazu Suematsu, Toshiyuki Hayase

Memoirs of the Faculty of Engineering, Nagoya University　37　(2)　117-172　1985/10
Growing Process and Structure of Axisymmetric Vortex Breakdown (1st Rep. An Inviscid Linear Model of the Growing Process of a Bubble) Peer-reviewed

HAYASE Toshiyuki

Transactions of Japan Society of Mechanical Engineers　51　(467)　2288-2295　1985
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/kikaib.51.2288 　

ISSN： 0387-5016

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This paper treats the vortex breakdown of the axisymmetric type in a swirling pipe flow, in reder to clarify the growing process of the bubble. The unsteady flow field is investigated based on the inviscid linear theory of the internal wave (inertia wave). The expression of the time dependent flow field with the internal wave propagation whibh satisfies the condition of arbitrary velocity change at the upstream boundary of the circular pipe, is derived. Using this expression, the transition of the flow field, the streamlines and the streaklines calculated by computer, are examined. The unsteady flow field, as the result of a sudden azimuthal velocity change at the upstream boundary, clearly shows the birth of the bubble and the growing process into a stationary state. The theoretical results are compared with the experimental growing process of the bubble in an actual swirling pipe flow obtained by the visualization technique. Both results agree with each other fairly well concerning the bubble structure during the growing period. The behaviour of the flulid elements which are entrained into the bubble is also mentioned from the results of calculated pathlines.
EXPERIMENTS ON THE ELASTOID-INERTIA OSCILLATIONS OF A RIGIDLY ROTATING FLUID IN A CYLINDRICAL VESSEL Peer-reviewed

T ITO, Y SUEMATSU, T HAYASE, T NAKAHAMA

BULLETIN OF THE JSME-JAPAN SOCIETY OF MECHANICAL ENGINEERS　27　(225)　458-467　1984

DOI： 10.1299/jsme1958.27.458 　

ISSN： 0021-3764
Experiments on the Elastoid-Inertia Oscillations of a Rigidly Rotating Fluid in a Cylindrical Vessel Peer-reviewed

伊藤忠哉, 末松良一, 早瀬敏幸, 中浜敬文

Transactions of Japan Society of Mechanical Engineers　49　(443)　1398-1409　1983/07
Publisher:
DOI： 10.1299/kikaib.49.1398 　

ISSN： 0387-5016
EXPERIMENTS ON THE PRECESSION OF THE VORTEX .1. ON THE OSCILLATORY PHENOMENA IN A SWIRLING PIPE-FLOW Peer-reviewed

T ITO, Y SUEMATSU, N KANDA, T HAYASE

BULLETIN OF THE JSME-JAPAN SOCIETY OF MECHANICAL ENGINEERS　26　(218)　1348-1356　1983

ISSN： 0021-3764
On the Oscillatory Phenomena in a Swirling Pipe Flow 1st Report, Experiments on the Precession of the Vortex Peer-reviewed

伊藤忠哉, 末松良一, 神田直美, 早瀬敏幸

Transactions of Japan Society of Mechanical Engineers　48　(436)　2472-2483　1982/12
Publisher:
DOI： 10.1299/kikaib.48.2472 　

ISSN： 0387-5016
Vortex Breakdown Phenomena in a Circular Pipe 3rd Report, Comparison between Theory and Experiment on the Flow Pattern of Breakdown Peer-reviewed

末松良一, 伊藤忠哉, 早瀬敏幸, 堀藤夫

Transactions of Japan Society of Mechanical Engineers　47　(421)　1736-1747　1981/09
Publisher:
DOI： 10.1299/kikaib.47.1736 　

ISSN： 0387-5016

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Misc. 280

Numerical simulation of real-world flows Invited Peer-reviewed

Toshiyuki Hayase

Fluid Dynamics Research　47　(5)　1-19　2015/09/23
Publisher: Institute of Physics Publishing
DOI： 10.1088/0169-5983/47/5/051201 　

ISSN： 0169-5983
F051003 Flow Analysis by Integrating Experimental Measurement and Numerical Simulation Invited

HAYASE Toshiyuki

Mechanical Engineering Congress, Japan　2012　"F051003-1"-"F051003-4"　2012/09/09
Publisher: The Japan Society of Mechanical Engineers

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High repetition rate simultaneous planar laser induced fluorescence (PLIF) of CH and OH radicals and stereoscopic particle imaging velocimetry (PIV), both at 10 kHz, was developed. The high repetition simultaneous system is applied to methane-air turbulent jet premixed flame to show the performance of developed system. The obtained simultaneous CH and OH PLIF images well represent flame dynamics in turbulent jet premixed flame. Simultaneously obtained three-component velocity vectors also represent relation between fluid velocity and flame dynamics. From temporal analyses, the injection frequency of the large-scale unburnt mixture island is clarified. The creation of small scale unburnt mixture islands from the large scale ones, which may contribute the enhancement of turbulent burning velocity, is also presented. For general understanding of flame structure, Proper Orthogonal Decomposition (POD) analysis has been applied to the OH PLIF images.
Analysis of Real-World Flows by Measurement-Integrated Simulation

HAYASE Toshiyuki

Turbomachinery　47　(9)　537-545　2019/09
Publisher: ターボ機械協会 ; 1973-
ISSN： 0385-8839
Medical Application of Measurement-Integrated Blood Flow Analysis

50　(4)　174-177　2019/07
Publisher: 日本フルードパワーシステム学会
ISSN： 1346-7719
Fluid Mechanical Effects of Near Wall Blood Flow Field on Endothelial Cell Damage:Comparison of Peeling Rate of HUVEC and HAEC in Oblique Flow Load Experiment

INOUE Kosuke, HAYASE Toshiyuki, MIYAUCHI Suguru

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2019　(0)　2G33　2019
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2019.31.2G33 　
Finite element analysis for flows in a tumor microenvironment considering a leakage to interstitium:Evaluation of the validity of the proposed method

TAKEDA Tomofumi, MIYAUCHI Suguru, HAYASE Toshiyuki

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2019　(0)　2G23　2019
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2019.31.2G23 　
Fundamental Study of MR-Measurement-Integrated Simulation of Heart-Aorta-System:Bloodflow of Ascending Aorta．

HORI Yuki, MIYAUCHI Suguru, HAYASE Toshiyuki, Lalande Alain, Christophe Jean-Joseph

The Proceedings of the JSME Conference on Frontiers in Bioengineering　2019　(0)　1C23　2019
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebiofro.2019.30.1C23 　
Two-dimensional-ultrasonic-measurement-integrated blood flow analysis for the arm artery:(Blood flow in radial artery)

KIMURA Seiichi, MIYAUCHI Suguru, HAYASE Toshiyuki

The Proceedings of the JSME Conference on Frontiers in Bioengineering　2019　(0)　1C31　2019
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebiofro.2019.30.1C31 　
Numerical Analysis of the Influence of Aortic Stenosis on Blood Flow Field in the Left Ventricle:(Influence of Ejection Fraction)

TSUYOSHI Tsuyoshi, MIYAUCHI Suguru, HAYASE Toshiyuki

The Proceedings of the JSME Conference on Frontiers in Bioengineering　2019　(0)　1C22　2019
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebiofro.2019.30.1C22 　
Numerical Analysis of the Blood Outflow Velocity Distribution of a Left Ventricle

KOSAKA Shuta, MIYAUCHI Suguru, HAYASE Toshiyuki

The Proceedings of the JSME Conference on Frontiers in Bioengineering　2019　(0)　1C21　2019
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebiofro.2019.30.1C21 　
Finite element analysis for flows in a tumor microenvironment considering a leakage to interstitium:Applications to two-dimensional problems

TAKEDA Tomofumi, MIYAUCHI Suguru, HAYASE Toshiyuki

The Proceedings of the JSME Conference on Frontiers in Bioengineering　2019　(0)　1C34　2019
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebiofro.2019.30.1C34 　
Fundamental study of Three-Dimensional Ultrasonic-Measurement-Integrated Blood Flow Analysis System:Blood Vessel Shape Extraction

KUDO Hirose, MIYAUCHI Suguru, HAYASE Toshiyuki, INOUE Kosuke

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2019　(0)　2G35-717　2019
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2019.31.2G35 　
Numerical Analysis of the Influence of Heart Disease on Blood Flow Field in the Left Ventricle:Influence of Aortic Stenosis

TAKADA Tsuyoshi, MIYAUCHI Suguru, HAYASE Toshiyuki

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2019　(0)　2G26-613　2019
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2019.31.2G26 　
Two-dimensional fluid analysis for flows in a simple-shaped tumor capillary model considering a leakage to interstitium

MIYAUCHI Suguru, HAYASE Toshiyuki

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2018　(0)　2F09　2018
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2018.30.2F09 　
182 Elucidation of Mechanisms of FBG vital sensing by Ultrasonic-Measurement-Integrated simulation::Experiment using Ultrasound Flow Phantom

HARADA Daisuke, MIYAUCHI Suguru, HAYASE Toshiyuki, INOUE Kosuke, SHIRAI Atsushi, KOYAMA Shouhei, ISHIZAWA Hiroaki

The Proceedings of Conference of Tohoku Branch　2018　(0)　161-162　2018
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmeth.2018.53.161 　
Fundamental evaluation of a pulse wave measurement system using a wrist pulsatile flow model:Analysis of measured signal, blood pressure and vessel deformation

TSUBOI Tatsuya, SHIRAI Atsushi, MIYAUCHI Suguru, HAYASE Toshiyuki

The Proceedings of the JSME Conference on Frontiers in Bioengineering　2018　(0)　1B31　2018
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebiofro.2018.29.1B31 　
Study of Hemodynamic Parameters to Identify Thickening and Thinning Parts of Cerebral Aneurysm Wall:Evaluation of the Parameters based on Analysis of Transport Equation

AOKI Kazumasa, MIYAUCHI Suguru, HAYASE Toshiyuki, SUGIYAMA Shin-ichiro, TOMINAGA Teiji

The Proceedings of the JSME Conference on Frontiers in Bioengineering　2018　(0)　1C25　2018
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebiofro.2018.29.1C25 　
Numerical Analysis of the Effect of the Inner Structure of a Left Ventricle on the Blood Flow Field:Effect of Papillary Muscles, Trabeculae Carneaes and Torsional Motion

HOSOI Koichi, MIYAUCHI Suguru, HAYASE Toshiyuki

The Proceedings of the JSME Conference on Frontiers in Bioengineering　2018　(0)　1C22-623　2018
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebiofro.2018.29.1C22 　
Investigation of Non-equilibrium Turbulence and Its Application to Flow Control (Cases of inhomogeneous, anisotropic and compressible turbulence)

Y. Sakai, K. Nagata, Y. Ito, K. Iwano, T. Watanabe, T. Hayase, K. Takamure, K. Tanaka, S. Nagaya

Proc. of the 17th International Symposium on Advanced Fluid Information (AFI-2017)　1 page　2017/11
Direct Numerical Simulations of Interaction between Planar Shock Wave and Homogeneous Isotropic Turbulence at Low Turbulent Mach Number Peer-reviewed

K. Tanaka, T. Watanabe, K. Nagata, A. Sasoh, Y. Sakai, T. Hayase

Proc. of the 31st International Symposium on Shock Waves (ISSW31)　USB (6 pages)　2017/07

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The 31st International Symposium on Shock Waves (ISSW31) will be held July 9-14, 2017, at Toyoda Auditorium, Nagoya University, Nagoya, Japan. This will be the third ISSW held in Japan, after 26 years from ISSW-18 in Sendai. The symposium will be organized with strong supports from International Shock Wave Institute (ISWI), Shock Wave Research Society of Japan, School of Engineering of Nagoya University, and some other societies, organizations, governments and industries. ISSW provides excellent forum of shock wave research and its applications to science, engineering, medical and other various fields. As well as scientific programs, participants will enjoy cultural activities including watching Grand Sumo Tournament held during the symposium period.
先進的医用超音波イメージングに関する研究

田邉将之, 内藤優, 西本昌彦, 橋本浩, 地挽隆夫, 島崎正, 宮内優, 井上浩介, 早瀬敏幸

東北大学流体科学研究所共同利用・共同研究拠点流体科学研究拠点活動報告書　2015　221‐224　2017/03
Investigation of Non-equilibrium Turbulence and Its Application to Flow Control (Cases of Mixing Layer, Grid Turbulence and Jet)

Y. Sakai, K. Nagata, Y. Ito, K. Iwano, T. Watanabe, T. Hayase, K. Takamure, M. Li

Proc. of the 16th International Symposium on Advanced Fluid Information (AFI-2016)　Paper No. CRF-57, pp.116-117　2016/10
二次元超音波計測融合血流解析における超音波計測のスペックルノイズの影響

門脇弘子, 早瀬敏幸, 船本健一, 宮内優, 井上浩介, 島崎正, 地挽隆夫, 見山広二

超音波TECHNO　5-6　15-20　2016/06
Publisher: 日本工業出版
外乱がtwinkling artifactに与える影響

田邉将之, 内藤優, 橋本浩, 地挽隆夫, 島崎正, 宮内優, 井上浩介, 早瀬敏幸, 西本昌彦

超音波医学　43　(Suppl.)　S768(J‐STAGE)-S768　2016/04/15
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176
2D34 Investigation of Permeability of Endothelial Cell Monolayer by Using Microfluidic Device with Controllability of Oxygen Tension

MATSUBARA Kento, FUNAMOTO Kenichi, ZERVANTONAKIS Ioannis K., FUNAMOTO Kiyoe, ITO Takuya, MASAMUNE Jun, KIMURA Yoshitaka, HAYASE Toshiyuki, KAMM Roger D.

2016　(28)　"2D34-1"-"2D34-5"　2016/01/09
Publisher: The Japan Society of Mechanical Engineers

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Permeability changes of an endothelial cell (EC) monolayer are related to many diseases. This study evaluated permeability of the EC monolayer under normoxia and hypoxia by using fluorescent dextrans of two different molecular weights in a microfluidic device with controllability of oxygen tension. As the results, permeability of the EC monolayer increased by hypoxic exposure, and the increase of the permeability measured by fluorescent dextran of 10 kDa was smaller than that measured by fluorescent dextran of 70 kDa. The results indicated that the size-selectivity of EC monolayer became weaken under hypoxia.
2F42 Validation of Accuracy of Velocity Vectors in Two-Dimensional Ultrasonic-Measurement-Integrated Blood Flow Analysis

KADOWAKI Hiroko, HAYASE Toshiyuki, MIYAUCHI Suguru, INOUE Kosuke, SHIMAZAKI Tadashi, JIBIKI Takao, MIYAMA Koji

2016　(28)　"2F42-1"-"2F42-5"　2016/01/09
Publisher: The Japan Society of Mechanical Engineers

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Information on hemodynamics is essential for elucidation of mechanisms and development of novel diagnostic methods for circulatory diseases. Two-dimensional ultrasonic-measurement-integrated (2D-UMI) blood flow analysis system provides detailed information on intravascular hemodynamics by feeding back an ultrasonic measurement to a numerical blood flow simulation. The purpose of this study was to clarify analysis accuracy of velocity vectors in 2D-UMI blood flow analysis. 2D-UMI analysis was performed for ultrasonic measurement data of a steady flow of blood-mimicking fluid in a model of a human carotid artery with a stenosis, and the analysis result was compared with corresponding three-dimensional computational fluid dynamics (3D-CFD) analysis result. As a result, the velocity vector profile deflected to the lower wall side obtained in 3D-CFD analysis result was properly reproduced in the 2D-UMI analysis.
168 Blood Flow Simulation in Left Ventricle Based on Magnetic Resonance Imaging Data : Influence of Structures on Ventricular Surface

YAMADA Tomomi, HAYASE Toshiyuki, MIYAUCHI Suguru

2016　(51)　133-134　2016
Publisher: The Japan Society of Mechanical Engineers
B106 Measurement of permeability of endothelial monolayer under hypoxia by using microfluidic device

MATSUBARA Kento, FUNAMOTO Kenichi, ZERVANTONAKIS Ioannis K., FUNAMOTO Kiyoe, ITO Takuya, MASAMUNE Jun, KIMURA Yoshitaka, HAYASE Toshiyuki, KAMM Roger D.

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2015　(26)　35-36　2015/10/01
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
7・8・1 生体流動(7・8 生体・生物流れ,7.流体工学,<特集>機械工学年鑑)

早瀬敏幸

日本機械学會誌　118　(1161)　472-473　2015/08/05
Publisher: 一般社団法人日本機械学会
ISSN： 0021-4728
機械工学年鑑，7. 流体工学

西山秀哉, 福西祐, 伊澤精一郎, 浅井圭介, 澤田恵介, 孫明宇, 祖山均, 石本淳, 山本悟, 伊賀由佳, 須藤誠一, 中野政身, 佐藤岳彦, 高奈秀匡, 徳増崇, 米村茂, 早瀬敏幸, 石川拓司

日本機械学会誌　118　(1161)　27-33　2015/08/05
Publisher: 日本機械学会
生体流動

早瀬敏幸

日本機械学会誌　118　(1161)　472-473　2015/08/05
2A24 Investigation of setting of upstream boundary in computational hemodynamic analysis in a cerebral aneurysm

SUZUKI Daichi, FUNAMOTO Kenichi, SUGIYAMA Shin-ichiro, HAYASE Toshiyuki, TOMINAGA Teiji

2015　(27)　317-318　2015/01/08
Publisher: The Japan Society of Mechanical Engineers
1D42 Measurement of frictional characteristics of erythrocytes on endothelial cells with an inclined centrifuge microscope : influence of normal component of inclined centrifugal force

INOUE Kosuke, HAYASE Toshiyuki, FUNAMOTO Kenichi, SHIRAI Atsushi

2015　(27)　169-170　2015/01/08
Publisher: The Japan Society of Mechanical Engineers
1B11 Investigation on reproduction of pressure field by three-dimensional unsteady ultrasonic-measurement-integrated blood flow simulation

FUNAMOTO Kenichi, HAYASE Toshiyuki

2015　(27)　49-50　2015/01/08
Publisher: The Japan Society of Mechanical Engineers
1B13 Experimental validation of analysis accuracy in two-dimensional ultrasonic-measurement-integrated simulation system

KADOWAKI Hiroko, HAYASE Toshiyuki, FUNAMOTO Kenichi, INOUE Kosuke, SHIMAZAKI Tadashi, JIBIKI Takao, MIYAMA Koji

2015　(27)　53-54　2015/01/08
Publisher: The Japan Society of Mechanical Engineers
1C34 Evaluation of permeability of endothelial monolayer by using hypoxia microfluidic device

MATSUBARA Kento, FUNAMOTO Kenichi, Zervantonakis Ioannis, FUNAMOTO Kiyoe, ITO Takuya, MASAMUNE Jun, KIMURA Yoshitaka, HAYASE Toshiyuki, KAMM Roger

2015　(27)　121-122　2015/01/08
Publisher: The Japan Society of Mechanical Engineers
超音波計測と計測融合シミュレーションによる血圧場と血流場の同時解析システム

曾根周作, 早瀬敏幸, 船本健一, 白井敦

バイオエンジニアリング講演会講演論文集　27th　2015

ISSN： 1348-2920
空間発展する乱流の構造に及ぼす外部乱れの影響の解明およびその熱流動制御への応用

酒井康彦, 早瀬敏幸, 長田孝二, 寺島修, 呉楠楠, 夏爽, 渡邉智昭

東北大学流体科学研究所共同利用・共同研究拠点流体科学研究拠点活動報告書　2013　61-62　2014/10
Effects of External Disturbances on Spatial Development of Turbulence and toward the Control of Thermo-Fluid Dynamics (Cases of Boundary Layer, Wake, and Jet)

Y. Sakai, K. Nagata, Y. Ito, T. Hayase, S. Xia, Y. Zhou, T. Watanabe, A. Sasoh, N. Wu, K. Takeuchi

Proc. of the 14th International Symposium on Advanced Fluid Information　170-171　2014/10
Heat Transfer in a Developing Region of a Boundary Layer Affected by a Wake of a Square Bar

S. Xia, Y. Ito, K. Nagata, Y. Sakai, T. Hayase

Proc. of the 11th International Conference on Flow Dynamics　606-607　2014/10
The Helical Behavior of the Single-Square Grid-Generated Turbulence

Y. Zhou, K. Nagata, Y. Sakai, Y. Ito, T. Hayase

Proc. of the 11th International Conference on Flow Dynamics　544-545　2014/10
Numerical Study on a Boundary Layer with Heat Transfer Affected by a Wake of a Square Bar Peer-reviewed

S. Xia, Y. Ito, K. Nagata, Y. Sakai, T. Hayase

Journal of Fluid Science and Technology　9　(3)　No.14-00042 (9pages)　2014/09

DOI： 10.1299/jfst.2014jfst0061 　
Influence of Reynolds Number on Coherent Structure, Flow Transition and Evolution of Plane Jet Peer-reviewed

N. Wu, Y. Sakai, K. Nagata, H. Suzuki, O. Terashima, T. Hayase

Journal of Fluid Science and Technology　9　(2)　13- 00288 (14pages)　2014/07

DOI： 10.1299/jfst.2014jfst0013 　
Twinkling Sign機序解明のための超音波照射による微粒子挙動の光学観察

LIU LEI, FUNAMOTO KEN'ICHI, TANABE MASAYUKI, HAYASE TOSHIYUKI

超音波医学　41　(Suppl.)　S449-S449　2014/04/15
Publisher: (一社)日本超音波医学会
ISSN： 1346-1176
ソノサイトメトリーの基盤技術の検討

小松洋介, 長岡亮, 船本健一, 早瀬敏幸, 政氏伸夫, 金井浩, 西條芳文

超音波医学　41　(Suppl.)　S481-S481　2014/04
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176
超音波計測融合シミュレーションにおける血流量推定精度の向上

門脇弘子, 早瀬敏幸, 船本健一, 曾根周作, 島崎正, 地挽隆夫, 見山広二, 劉磊

超音波医学　41　(Suppl.)　S480-S480　2014/04
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176

eISSN： 1881-9311
光電脈派計測と超音波計測融合解析による血圧血流同時計測システムによるWI解析

曾根周作, 早瀬敏幸, 船本健一, 白井敦

超音波医学　41　(Suppl.)　S480-S480　2014/04
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176

eISSN： 1881-9311
DNS Study on the Development of Boundary Layer with Heat Transfer under the Effects of External and Internal Disturbances Peer-reviewed

S. Xia, Y. Ito, K. Nagata, Y. Sakai, H. Suzuki, O. Terashima, T. Hayase

Journal of Fluid Science and Technology　9　(1)　No.13-00259 (13pages)-JFST0005　2014/03
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jfst.2014jfst0005 　

ISSN： 1880-5558

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The effects of external and internal disturbances on the development of boundary layer with heat transfer are investigated by means of direct numerical simulation (DNS) based on the finite difference scheme. The fractional step method is used to solve the governing equations. The external disturbance is generated by a regular turbulence-generating grid, while the internal disturbance is generated by a tripping object mounted on the wall. In order to clarify the momentum and heat transfer mechanism in a boundary layer under these effects, the instantaneous and statistical characteristics of velocity and temperature fields are presented and discussed along with their interactions. The results show that the boundary layer in the case with grid turbulence becomes turbulent even though the Reynolds number based on the momentum thickness is low. On the other hand, in the case with the tripping object, only low-amplitude fluctuations are generated in the vicinity of the tripping object and the boundary layer does not fully developed. The grid increases the skin friction and enhances heat transfer more significantly than the tripping object. It is also found that strong strain in the viscous sublayer, which is induced by the vortical motion in the buffer layer, contributes to the enhancement of heat transfer.
流体解析における計測とシミュレーションの融合 Invited

早瀬敏幸

機械の研究　66　(2)　93-101　2014/02
Publisher: 養賢堂
ISSN： 0368-5713
1G11 Comparison of hemodynamic parameters and wall characteristics of cerebral aneurysms

SUZUKI Daichi, FUNAMOTO Kenichi, SUGIYAMA Shin-ichiro, NAKAYAMA Toshio, HAYASE Toshiyuki, TOMINAGA Teiji

2014　(26)　207-208　2014/01/10
Publisher: The Japan Society of Mechanical Engineers
2B25 Validations of 3D blood vessel reconstruction and blood flow analysis by ultrasonic-measurement-integrated flow-structure interaction simulation system for small animals

SAKANISHI Sanga, HAYASE Toshiyuki, FUNAMOTO Kenichi, SONE Shusaku

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2014　(26)　309-310　2014/01/10
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2014.26.309 　
2B46 The influence of axial variation of the plane flow rate on two-dimensional ultrasonic-measurement-integrated simulation of blood flow in a common carotid artery

MATSUMOTO Takuya, FUNAMOTO Kenichi, HAYASE Toshiyuki

2014　(26)　335-336　2014/01/10
Publisher: The Japan Society of Mechanical Engineers
2B47 Consideration on the evaluation function of blood flow rate estimation in ultrasonic-measurement-integrated simulation

KADOWAKI Hiroko, HAYASE Toshiyuki, FUNAMOTO Kenichi, SONE Shusaku, JIBIKI Takao, HASHIMOTO Hiroshi, MIYAMA Koji, LIU Lei

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2014　337-338　2014
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2014.26.337 　
168 Fundamental Study of Interaction between Red Blood Cell and Endothelial Cell under Inclined Centrifugal Force : Reproduction of Friction Characteristics by Numerical Analysis Using Interaction Model

YATSUYANAGI Akira, HAYASE Toshiyuki, INOUE Kosuke, FUNAMOTO Kenichi, SHIRAI Atsushi

2014　(49)　133-134　2014
Publisher: The Japan Society of Mechanical Engineers
MR計測融合シミュレーションによる脳動脈瘤破裂予測

杉山慎一郎, 船本健一, 早瀬敏幸, 清水宏明, 冨永悌二

東北大学流体科学研究所共同利用・共同研究拠点流体科学研究拠点活動報告書　2013　2014
模擬モデルを用いた爆風による外傷性脳損機序解明研究

大谷清伸, 中川敦寛, 沼田大樹, 合田圭介, 荒船龍彦, 鷲尾利克, 古川宗, Mark Richardson, 早瀬敏幸

日本機械学会第26回バイオエンジニアリング講演　33-34　2014
Characteristics of Turbulent/non-turbulent Interface in a Turbulent Planar Jet with a Chemical Reaction

Tomoaki Watanabe, Yasuhiko Sakai, Kouji Nagata, Osamu Terashima, Yasumasa Ito, Toshiyuki Hayase

APS Meeting Abstracts　2013/11
DNS Study on Boundary Layer with Heat Transfer affected by Disturbances Created by a Grid and Small Cubes

S. Xia, Y. Ito, K. Nagata, Y. Sakai, H. Suzuki, O. Terashima, T. Hayase

Proc. of the 10th International Conference on Flow Dynamics (ICFD)　126-127　2013/11

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November 25-27, 2013 Sendai International Center
Reynolds-Number Dependency of Budget of Kinetic Energy and Turbulence Structure in Plane Jet

N. Wu, Y. Sakai, K. Nagata, H. Suzuki, O. Terashima, T. Hayase

Proc. of the 10th International Conference on Flow Dynamics (ICFD)　76-77　2013/11

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November 25-27, 2013 Sendai International Center
Scalar Transfer across a Turbulent/non-turbulent Interface in a Planar Jet

Tomoaki Watanabe, Yasuhiko Sakai, Kouji Nagata, Osamu Terashima, Yasumasa Ito, Toshiyuki Hayase

2013/10/02

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This fluid dynamics video is an entry for the Gallery of Fluid Motion of the 66th Annual Meeting of the APS-DFD. In this video, the scalar transfer across the turbulent/non-turbulent (T/NT) interface in a planar jet is investigated by using a direct numerical simulation. Visualization of the scalar flux across the T/NT interface shows that the diffusive species premixed in the ambient flow is transferred into the turbulent region mainly across the leading edge (Here, the leading edge is the T/NT interface across which the turbulent fluid turns into the non-turbulent fluid in the streamwise direction).
空間発展する乱流の構造に及ぼす外部乱れの影響の解明およびその熱流動制御への応用

酒井康彦, 早瀬敏幸, 長田孝二, 寺島修, 呉楠楠, 夏爽, 渡邉智昭

東北大学流体科学研究所共同利用・共同研究拠点流体科学研究拠点活動報告書　2012　37-38　2013/10
1109 DNS STUDY ON PRESSURE CHARACTERISTICS OF FRACTAL-GENERATED TURBULENCE

Hiroki Suzuki, Kouji Nagata, Yasuhiko Sakai, Toshiyuki Hayase, Yutaka Hasegawa, Tatsuo Ushijima

Jets, wakes and separated flows : proceedings of International Conference on Jets, Wakes and Separated Flows, ICJWSF　2013　(4)　"1109-1"-"1109-4"　2013/09/16
Publisher: The Japan Society of Mechanical Engineers

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We discuss the fundamental characteristics of pressure fluctuation in fractal-generated turbulence, generated by a square-type fractal grid, along the center line. Several experiments in recent years have indicated an unconventional nature of fractal-generated turbulence, in contrast to conventional grid turbulence and homogeneous isotropic turbulence, although all fall into the general category of grid turbulence. Although numerical analyses such as direct numerical simulations can investigate quantities that are difficult to measure, such as fluctuation in static pressure and derivatives of velocity fluctuations, there have been few numerical investigations on fractal-generated turbulence. Therefore, in this research we attempt to simulate such quantities of fractalgenerated turbulence along the center line, where previous experiments focused on turbulence characteristics. The Reynolds number based on the effective mesh size is 2500. The computational domain size in the streamwise direction is larger than one hundred times the effective mesh size. The numerical technique of our direct numerical simulation is based on the higher order Runge-Kutta method and the finite-difference method basically consisting of the Morinishi scheme. The results show that the ratio between the rms fluctuating static pressure and the intensity of the velocity fluctuation, which would be constant according to theories of homogeneous isotropic turbulence, increases along the streamwise direction.
軟組織内微細石灰化Twinkling Signに関する実験的研究:粒子径,粒子種類が与える影響

LIU LEI, FUNAMOTO KEN'ICHI, TANABE MASAYUKI, HAYASE TOSHIYUKI

超音波医学　40　(Suppl.)　S408-S408　2013/04/15
Publisher: (一社)日本超音波医学会
ISSN： 1346-1176
228 等方性乱流場と平面衝撃波の相互干渉に関する直接数値シミュレーション(OS3-3 乱流現象の実験と数値シミュレーション(3),OS3 乱流現象の実験と数値シミュレーション)

齋藤大輝, 酒井武治, 佐宗章弘, 長田孝二, 酒井康彦, 北村拓也, 早瀬敏幸

東海支部総会講演会講演論文集　2013　(62)　127-128　2013/03/18
Publisher: 一般社団法人日本機械学会
3C14 Comparison of three-dimensional blood flow analysis in cerebral aneurysm with MRI measurement

SUZUKI Daichi, FUNAMOTO Kenichi, HAYASE Toshiyuki, SUGIYAMA Shin-ichiro

2013　(25)　547-548　2013/01/08
Publisher: The Japan Society of Mechanical Engineers
2A08 Validation of two-dimensional ultrasonic-measurement-integrated simulation for three-dimensional blood flow in common carotid artery

MATSUMOTO Takuya, FUNAMOTO Kenichi, HAYASE Toshiyuki

2013　(25)　247-248　2013/01/08
Publisher: The Japan Society of Mechanical Engineers
2A10 Analysis of blood flow in mouse carotid artery by ultrasonic-measurement-integrated flow-structure interaction simulation system for small animal

SAKANISHI Sanga, HAYASE Toshiyuki, FUNAMOTO Kenichi, SONE Shusaku

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2013　(25)　251-252　2013/01/08
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2013.25.251 　
2C10Observation of influence of differentiation on motion of HL60 cells on a flat glass plate using the inclined centrifuge microscope

SUGIYAMA Yoshiro, SHIRAI Atsushi, HAYASE Toshiyuki

2013　(25)　331-332　2013/01/08
Publisher: The Japan Society of Mechanical Engineers
2A09 Estimation of Blood Viscosity Based on Ultrasonic-Measurement-Integrated Simulation

KADOWAKI Hiroko, FUNAMOTO Kenichi, HAYASE Toshiyuki, SONE Shusaku, OGASAWARA Masafumi, JIBIKI Takao, HASHIMOTO Hiroshi, MIYAMA Koji, LIU Lei

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2013　(25)　249-250　2013/01/08
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2013.25.249 　
超音波Mモードイメージングと光電容積脈波センシングによる脈波同定の比較

曾根周作, 早瀬敏幸, 船本健一

超音波医学　40　2013

ISSN： 1346-1176
超音波計測融合シミュレーションによる生体内の血液粘度の推定

門脇弘子, 船本健一, 早瀬敏幸, 曾根周作, 地挽隆夫, 橋本浩, 見山広二, LIU Lei

超音波医学　40　2013

ISSN： 1346-1176
MR計測融合シミュレーションによる脳動脈瘤破裂予測

杉山慎一郎, 船本健一, 早瀬敏幸, 清水宏明, 冨永悌二

東北大学流体科学研究所共同利用・共同研究拠点流体科学研究拠点活動報告書　2012　2013
226 Numerical Simulation of a Reactive Planar Jet by Using DNS and PDF Methods

WATANABE Tomoaki, SAKAI Yasuhiko, NAGATA Kouji, TERASHIMA Osamu, ITO Yasumasa, HAYASE Toshiyuki

The Proceedings of Conference of Tokai Branch　2013　(0)　123-124　2013
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmetokai.2013.62.123 　
2C16 The relationship between geometrical change based on inlet pressure and blood flow pattern in a stenotic vessel

SHIMIZU Yasutomo, LIU Lei, SHIDA Shuya, FUNAMOTO Kenichi, HAYASE Toshiyuki, OHTA Makoto

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2013　(0)　343-344　2013
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2013.25.343 　
爆風による外傷性脳損傷機序解明に関する研究

大谷清伸, 中川敦寛, 合田圭介, 荒船龍彦, 鷲尾利克, 早瀬敏幸

平成24年度衝撃波シンポジウム　303-304　2013
爆風による外傷性脳損傷機序解明のための模擬モデル実験

大谷清伸, 中川敦寛, 沼田大樹, 合田圭介, 荒船龍彦, 鷲尾利克, 古川宗, Mark Richardson, 早瀬敏幸

高速度イメージングとフォトニクスに関する総合シンポジウム　22　2013
Influence of surface model extraction parameter on computational fluid dynamics modeling of cerebral aneurysms (vol 45, pg 2355, 2012)

Shunsuke Omodaka, Takashi Inoue, Kenichi Funamoto, Shin-ichirou Sugiyama, Hiroaki Shimizu, Toshiyuki Hayase, Akira Takahashi, Teiji Tominaga

JOURNAL OF BIOMECHANICS　45　(16)　2947-2947　2012/11

DOI： 10.1016/j.jbiomech.2012.09.012 　

ISSN： 0021-9290
C207 Improvement of extraction of vessel shape in ultrasonic-measurement-integrated flow-structure interaction simulation system for small animal experiment

Sakanishi Sanga, Hayase Toshiyuki, Funamoto Kenichi, Sone Shusaku

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2012　(23)　181-182　2012/10/04
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebiofro.2012.23.181 　

ISSN： 1348-2939
A103 Blood Flow Analysis in Carotid Bifurcation with Two-Dimensional Ultrasonic-Measurement-Integrated Simulation

Kadowaki Hiroko, Funamoto Kenichi, Hayase Toshiyuki, Sone Shusaku, Ogasawara Masafumi, Jibiki Takao, Hashimoto Hiroshi, MIYAMA Koji

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2012　(23)　5-6　2012/10/04
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebiofro.2012.23.5 　

ISSN： 1348-2939
J024044 Verification of reflected pressure pulse waves at bifurcation of one-dimensional arterial vascular model of an arm

TAKASHIMA Minoru, SHIRAI Atsushi, HAYASE Toshiyuki

Mechanical Engineering Congress, Japan　2012　"J024044-1"-"J024044-5"　2012/09/09
Publisher: The Japan Society of Mechanical Engineers

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The pulse diagnosis is one of medical techniques in the traditional Chinese medicine. In the pulse diagnosis, a doctor put fingers onto radial artery of a patient and diagnoses diseases from the tactile sense of the pulse waves detected by the fingers with various indentation patterns of the artery. This diagnosis is a simple and non-invasive. And it is also said to be able to detect decline of the health. We have developed one dimensional mathematical model of arterial blood flow in an arm to reproduce the indentation of the radial artery by a finger, expecting essence of the diagnosis is in the change of the pulse waves by the indentation. This model takes into consideration bifurcation and reconnection of radial and ulnar arteries. In this research, we modified this model to quantitatively reproduce reflection of pressure waves at the bifurcation and reconnection, and it was verified by comparing the numerical result with analytical solution derived from characteristic impedance of the arteries.
J024021 Hydrodynamics of Water-jumping Insect

KAINUMA Toshiya, SUDO Seiichi, SHIRAI Atsushi, HAYASE Toshiyuki

Mechanical Engineering Congress, Japan　2012　"J024021-1"-"J024021-4"　2012/09/09
Publisher: The Japan Society of Mechanical Engineers

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This paper concerned with the relationship between the body structure and the locomotive functions of springtail. The jumping movements of springtails from the inside of the bubble at the air-water interface were analyzed from high-speed sequences of images captured at rate of 4500 frames per second. The results of an experiment aimed at elucidating the jumping mechanisms of water-floating springtails are described. The variation of vertical velocity during the springtail jump was analyzed. The microscopic structure of body was also clarified by a laser scanning microscope. The effect of drag reduction during the movements of springtail in the air was discussed with the analysis of jumping motion from the view point of hydrodynamics and microscopic observation of the structure on the body surface.
J024022 Numerical Simulation for Propulsion Mechanism of Small Aquatic Creatures : Influence of shape of single pleopod model on propulsion force in a steady laminar flow

INOUE Kosuke, SHIRAI Atsushi, HAYASE Toshiyuki, SUDO Seiichi

Mechanical Engineering Congress, Japan　2012　"J024022-1"-"J024022-4"　2012/09/09
Publisher: The Japan Society of Mechanical Engineers

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In this study, opossum shrimps were introduced to elucidate propulsion mechanism of small aquatic creatures by ciliated pleopods. A pleopod was simplified to a straight cylindrical stem of 1.0mm in length and 0.1mm in diameter with 10 much narrower cylinders perpendicularly projecting on its either side to mimic the cilia. Flow resistance acting on the pleopod in a uniform flow, which corresponds to the propulsion force in rowing it, was computed, and it was found that the resistance decreased when interval between the adjacent cilia was below 0.4 mm.
S054031 A Study on the Petal Surface Cells as the Plant Hydrodynamics

SUDO Seiichi, SHIONO Masahiro, SHIRAI Atsushi, HAYASE Toshiyuki

Mechanical Engineering Congress, Japan　2012　"S054031-1"-"S054031-4"　2012/09/09
Publisher: The Japan Society of Mechanical Engineers

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This paper is concerned with plant hydrodynamics. The water disappearance process from the cut dandelion petal was observed by a Color 3D Laser Scanning Microscope. Some morphological parameters and cell shape profiles of the petal surface of the dandelion, Taraxacum officinale, was measured. The time change in the surface-roughness of the petal surface was obtained. The stoma surface shape on the involucral scale was also measured. Processes to the cell death of a plant were discussed using the time change of the petal surface shape of dandelion.
Effects of External Disturbances on Spatially Developing Turbulence and Its Application to Control of Thermo-Fluid Dynamics

Y. Sakai, K. Nagata, T. Hayase, O. Terashima, N. Wu, S. Xia, T. Watanabe, T. Kitamura, K. Hiruta, H. Saito, T. Sakai, A. Sasoh, Y. Ito

Proc. of the 12th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2012)　156-157　2012/09
Numerical Simulation of a Reactive Liquid Jet by Combination of DNS and PDF Method

T. Watanabe, Y. Sakai, K. Nagata, O. Terashima, Y. Ito, T. Hayase

Proc. of the 9th International Conference on Flow Dynamics (ICFD)　102-103　2012/09
Direct Numerical Simulation of Eddy Diffusivity in a Plane Jet with a Second-Order Reaction Peer-reviewed

T. Watanabe, Y. Sakai, K. Nagata, H. Suzuki, Y. Ito, O. Terashima, T. Hayase

Proc. of the International Conference on Simulation Technology 2012 (JSST 2012)　USB　paper no. JSST2012_OS5-11 (4pa　2012/09

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JSST 2012 Date: Sep. 27-28, 2012 Venue: Port Island, Kobe
Visual Synergetics(9)Realization of Blood Flow Dynamics based on Visual Synergetics

17　4p　2012/05
Publisher: 日本計算工学会
106 Locomotion Mechanism of Beach Flea

AMANO Takuya, SUDO Seiichi, SHIRAI Atsushi, HAYASE Toshiyuki

2012　(47)　18-19　2012/03/13
Publisher: The Japan Society of Mechanical Engineers
105 Jump of Springtail on the Water Surface

KAINUMA Toshiya, SUDO Seiichi, SHIRAI Atsushi, HAYASE Toshiyuki

2012　(47)　16-17　2012/03/13
Publisher: The Japan Society of Mechanical Engineers
Numerical Simulation of Turbulence Genereted by the Multiscale Grid Invited

H. Suzuki, K. Nagata, Y. Sakai, H. Toshiyuki, Y. Hasegawa

Bulletin of the 2nd UK-Japan Bilateral Workshop and 1st ERCOFTAC Workshop on Turbulent Flows Generated/designed in Multiscale/fractal Ways: Fundamentals and Application　11　2012/03
8F23 Observation of influence of fMLP stimulation on behavior of HL60 cells on glass plate using the inclined centrifuge microscope

SATO Hiroki, SHIRAI Atsushi, HAYASE Toshiyuki

2012　(24)　"8F23-1"-"8F23-2"　2012/01/06
Publisher: The Japan Society of Mechanical Engineers
8F21 Influence of normal force on behavior of HL60 cells moving on HUVEC substrate

SHIRAI Atsushi, URANUMA Haruka, HAYASE Toshiyuki

2012　(24)　"8F21-1"-"8F21-2"　2012/01/06
Publisher: The Japan Society of Mechanical Engineers
8F24 Numerical Analysis of Levitation Mechanism of Red Blood Cell in Inclined Centrifuge Microscope : 2nd Report: Validity of Rigid Red Blood Cell Model for Reproduction of Friction Characteristics

OSHIBE Takashi, HAYASE Toshiyuki, FUNAMOTO Kenichi, SHIRAI Atsushi

2012　(24)　"8F24-1"-"8F24-2"　2012/01/06
Publisher: The Japan Society of Mechanical Engineers
頸動脈分岐部内血流の2次元超音波計測融合シミュレーョン

門脇弘子, 船本健一, 早瀬敏幸, 曾根周作, 小笠原正文, 地挽隆夫, 橋本浩, 見山広二

バイオエンジニアリング講演会講演論文集　24th (CD-ROM)　2012

ISSN： 1348-2920
2次元超音波計測融合シミュレーションによる頸動脈分岐部の非定常血流量推定

門脇弘子, 船本健一, 早瀬敏幸, 曾根周作, 小笠原正文, 地挽隆夫, 橋本浩, 見山広二

超音波医学　39　2012

ISSN： 1346-1176
MR計測融合シミュレーションによる脳動脈瘤破裂予測

杉山慎一郎, 船本健一, 清水宏明, 冨永悌二, 早瀬敏幸

東北大学流体科学研究所共同利用・共同研究拠点流体科学研究拠点活動報告書　2011　2012
8F36 Influence of plaque stiffness on steady flow with blood vessel stenosis biomodel

SHIMIZU Yasutomo, SHIDA Shuya, HAYASE Toshiyuki, OHTA Makoto

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2012　(0)　_8F36-1_-_8F36-2_　2012
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2012.24._8F36-1_ 　
生体模擬物質中を伝播する衝撃波現象

大谷清伸, 中川敦寛, 早瀬敏幸, 荒船龍彦, 鷲尾利克, 合田圭介

平成23年度衝撃波シンポジウム講演論文集　125-126　2012
C124 Effects of freestream turbulence on heat transfer in a turbulent boundary layer

Suzuki Hiroki, Nagata Kouji, Sakai Yasuhiko, Hayase Toshiyuki

Procee[d]ings of Thermal Engineering Conference　2011　63-64　2011/10/28
Publisher: The Japan Society of Mechanical Engineers

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The aim of this research is to investigate the effects of freestream turbulence (FST) in a main flow on turbulent structure and heat transfer in turbulent boundary layers (TBLs) by means of direct numerical simulation (DNS). The FST is generated by a turbulence-generating grid as in previous experimental studies. The results show that instantaneous and mean temperature profiles are affected by the FST in the outer region of the TBL. The rms temperature normalized by the friction temperature is enhanced by the FST.
A207 Contribution of ulnar artery on numerical reproduction of pulse wave measurement in pulse diagnosis

TAKASHIMA Minoru, SHIRAI Atsushi, HAYASE Toshiyuki

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2011　(22)　91-92　2011/10/06
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
B120 Numerical Analysis of Levitation Mechanism of Red Blood Cell in Inclined Centrifuge Microscope

OSHIBE Takashi, HAYASE Toshiyuki, FUNAMOTO Kenichi, SHIRAI Atsushi

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2011　(22)　77-78　2011/10/06
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
F051001 Integration of Measurement and Simulation in Flow Analysis

HAYASE Toshiyuki

Mechanical Engineering Congress, Japan　2011　"F051001-1"-"F051001-5"　2011/09/11
Publisher: The Japan Society of Mechanical Engineers

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Measurement-integrated (MI) simulation is a numerical flow analysis method with a feedback mechanism from measurement of a real flow. It correctly reproduces a real flow under inherent ambiguity in a mathematical model or a computational condition. In this paper we theoretically investigated the destabilization phenomenon of MI simulation, in which analysis error suddenly increases at some critical feedback gain. This phenomenon has been considered as instability of a closed-loop feedback system, but present study treated it as that of a numerical scheme. First, the mechanism of the destabilization phenomenon was investigated based on the sufficient condition of the convergence of iterative calculation of existing MI simulation. It was found that the feedback signal in the source term destabilized the iterative calculation. The validity of the present theoretical analysis was verified for examples treated in former studies of MI simulations. Occurrences of destabilization phenomenon in all the examples were well explained by the condition of this study, especially for cases of relatively small time steps and large feedback gains.
DNS on Spatially Developing Fractal Generated Turbulence with Heat Transfer Invited

H. Suzuki, K. Nagata, Y. Sakai, T. Hayase

Bulletin of the 1st UK-Japan Bilateral Workshop Turbulent Flows Generated/designed in Multiscale/fractal Ways: Fundamentals and Application　21　2011/03
格子乱流の影響を受けた乱流境界層の統計的特性（直接数値計算による空間発展解析） Peer-reviewed

鈴木博貴, 長田孝二, 酒井康彦, 早瀬敏幸

日本機械学会論文集(B編)　77　(775)　737-748　2011/03
9E-19 Numerical Simulation for Effect of Curved Pipe Movement on the Flow Inside 2^<th> Report : Effect of Inlet Velocity Distribution

INOUE Kosuke, HAYASE Toshiyuki, HIGUCHI Hiroshi

2010　(23)　537-538　2011/01/07
Publisher: The Japan Society of Mechanical Engineers
超音波計測融合シミュレーションと計測による上流速度を与えたシミュレーションの比較

曾根周作, 加藤宇海, 船本健一, 早瀬敏幸, 小笠原正文, 地挽隆夫, 橋本浩, 見山広二

超音波医学　38　2011

ISSN： 1346-1176
計測連成シミュレーションの臨床応用の検討と血流の局所微細構造の解明

早瀬敏幸

ナノ医工学年報　5　(1)　15-24　2011
Publisher: 東北大学グローバルCOEプログラム「新世紀世界の成長焦点に築くナノ医工学拠点」
ISSN： 1882-4692
脳動脈瘤破裂点の流体力学的特徴:コンピュータ流体解析による検討

面高俊介, 井上敬, 船本健一, 杉山慎一郎, 藤村幹, 清水宏明, 早瀬敏幸, 高橋明, 冨永悌二

脳循環代謝　23　(1)　2011

ISSN： 0915-9401
Rheological analysis of the mechanism of fetal brain hemorrhage.

T. Ito, K. Funamoto, K. Funamoto, K. Tanabe, A. Nakamura, T. Hayase, Y. Kimura

Eighth International Conference on Flow Dynamics　86-87　2011
DNS of Grid Turbulence with Scalar Transfer Using the Immersed Boundary Method and Fully Conservative Higher-Order Finite-Difference Schemes

K. Nagata, H. Suzuki, Y. Sakai, T. Hayase

Proc. of International Workshop on Process Intensification 2010 (IWPI2010)　85-86　2010/12

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December 2-3, 2010 Kyushu University INAMORI International Hall, Fukuoka Japan
フラクタル格子により生成されるマルチスケール誘起乱流の構造とスカラー拡散機構(第2報，DNSによる一様等方性と間欠性に及ぼす格子パラメータの影響の検討) Peer-reviewed

鈴木博貴, 長田孝二, 酒井康彦, 早瀬敏幸

日本機械学会論文集(B編)　76　(772)　2024-2031　2010/12
A204 Experimental study on effect of direction of orientation of endothelial cells on motion of neutrophils

URANUMA Haruka, SHIRAI Atsushi, HAYASE Toshiyuki

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2010　(21)　45-46　2010/11/11
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
B215 Evaluation of Wall Shear Stress in Carotid Artery with Ultrasonic-Measurement-Integrated Simulation

KATO Takaumi, FUNAMOTO Kenichi, HAYASE Toshiyuki, OGASAWARA Masafumi, JIBIKI Takao, HASHIMOTO Hiroshi, MIYAMA Koji

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2010　(21)　113-114　2010/11/11
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
B214 Development of Ultrasonic-Measurement-Integrated Simulation System for Small Animal Experiment : Confirmation Experiment

TANAKA Yuji, FUNAMOTO Kenichi, HAYASE Toshiyuki, INOUE Kosuke

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2010　(21)　111-112　2010/11/11
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
A104 Blood Flow Analysis in the Left Atrium with/without Atrial Fibrillation

KOIZUMI Ryo, FUNAMOTO Kenichi, HAYASE Toshiyuki, SHIBATA Muneichi

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2010　(21)　7-8　2010/11/11
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
W205 Blood Flow Simulation Integrated with Medical Measurement

Funamoto Kenichi, Hayase Toshiyuki

Fluids engineering conference ...　2010　619-622　2010/10/29
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882

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Measurement-integrated (MI) simulation, in which feedback signals are applied to the governing equations based on errors between measurement and numerical simulation, has been investigated to solve various problems related to fluid flows. As medical applications of MI simulation, the authors have proposed integration of medical measurement, such as ultrasound Doppler measurement or phase-contrast MRI (PC MRI), of blood flow velocity and a numerical simulation. Effects of feedback of errors in one- or three-directional velocity information between ultrasound Doppler measurement or PC MRI and the numerical simulation were examined by numerical experiments, respectively. Each MI simulation converged to the standard solution and yielded the hemodynamic stresses accurately and in detail.
可視化による知識発見のライフサイクル管理とその流動応用評価

FUJISHIRO Issei, HAYASE Toshiyuki, OOBAYASHI Shigeru, TAKESHIMA Yuriko

平成21年度公募共同研究報告書　(J09038)　79-80　2010/08
Publisher: 東北大学流体科学研究所
Fluid-Structure Interaction Simulation of a Red Blood Cell under Inclined Centrifugal Force

15　(2)　561-564　2010/05
Publisher: 日本計算工学会
ISSN： 1342-145X
Direct Numerical Simulation of Regular and Fractal-Grid Turbulence Using the Immersed Boundary Method and Fully Conservative Higher-Order Finite-Difference Schemes Peer-reviewed

H. Suzuki, K. Nagata, Y. Sakai, T. Hayase

International Review of Physics　4　(2)　83-90　2010/04
214 Eigenvalue Analysis of Measurement-Integrated Simulation of Two-Dimensional Blood Flow in the Vinicity of Aneurysm in the Descending Aorta

Funamoto Takakazu, Hayase Toshiyuki, Imagawa Kentaro, Funamoto Kenichi

2010　(45)　228-229　2010/03/12
Publisher: The Japan Society of Mechanical Engineers
0624 Dynamic Characteristics Analysis of Diseased Circulatory System with Lumped Parameter Model : 2^<nd> Report:Ventricular Septal Defect

KOIZUMI Ryo, HAYASE Toshiyuki, FUNAMOTO Kenichi

2009　(22)　279-279　2010/01/08
Publisher: The Japan Society of Mechanical Engineers
0434 Numerical Simulation for Effect of Curved Pipe Movement on the Flow Inside

INOUE Kosuke, HAYASE Toshiyuki, HIGUCHI Hiroshi

2009　(22)　259-259　2010/01/08
Publisher: The Japan Society of Mechanical Engineers
A Compensation Technique of Shaking of Successive Images Taken by the Inclined Centrifuge Microscope

SHIRAI Atsushi, HAYASE Toshiyuki

2010　215-215　2010
Publisher: 日本流体力学会

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The authors have observed motion of neutrophils on endothelial cells cultured on a flat glass plate using the inclined centrifuge microscope. The successive images of the neutrophils taken by the inclined centrifuge microscope were wobbly due to flatter of rotation of the rotor or vibration of the motor. The shaking of the images led some error in measuring the velocities of individual cells by PTV. The authors have compensated the shaking by sliding the images referring a cross-hair drawn on the glass plate as the index. The cross-hair, however, was blurred because the lines were out of focus of the microscope and the images were dark for the PTV, and thus, they sometimes failed in extracting the lines. Then, in this research, the authors introduced the Hough transformation to extract the lines. Moreover, they detected adherent cells through the images to eliminate remaining shaking of the images. Consequently, the shaking was eliminated within ±1 pixel.
Effect of Feedback of Zeroed Doppler Velocity on Ultrasonic-Measurement-Integrated Simulation of Blood Flow

Funamoto Kenichi, Hayase Toshiyuki, Saijo Yoshifumi, Yambe Tomoyuki

2010　216-216　2010
Publisher: 日本流体力学会

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Ultrasonic-measurement-integrated (UMI) simulation, in which feedback signals are applied to the governing equations based on errors between ultrasonic measurement and numerical simulation, has been investigated for reproduction of the blood flow field. In this study, the effects of wall filter and lack of data, which provide zero Doppler velocity, on UMI simulation were examined by a numerical experiment dealing with the blood flow field in the descending aorta with an aneurysm. Effects of wall filter and lack of data appeared in diastole and in the whole period, respectively. However, by not adding feedback signals where measured Doppler velocities were zero, the computational accuracy of the UMI simulation substantially improved for the sake of the feedback.
熱流体解析の最近の動向

早瀬敏幸

油空圧技術　49　1-4　2010/01
Turbulence Structure and Scalar Transfer in Fractal Generated Turbulence Invited

K. Nagata, Y. Sakai, H. Suzuki, T. Hayase

Proc. of the Japan-Korea CFD Workshop　CDROM　5 pages　2009/12
B212 Dynamic Characteristics Analysis of Diseased Circulatory System with Lumped Parameter Model 1^<st> Report : Heart Valve Disease

KOIZUMI Ryo, HAYASE Toshiyuki, FUNAMOTO Kenichi

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2009　(20)　115-116　2009/11/06
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
B108 Analysis of Clinical Data with Ultrasonic-Measurement-Integrated Simulation

KATTO Takaumi, FUNAMOTO Kenichi, HAYASE Toshiyuki, OGASAWARA Masafumi, JIBIKI Takao, HASHIMOTO Hiroshi, MIYAMA Koji

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2009　(20)　43-44　2009/11/06
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
B213 Blood Flow Simulation Integrated with Ultrasonic Measurement 9^<th> Report : Effect of Noise in Ultrasonic Measurement

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2009　(20)　117-118　2009/11/06
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
Direct Numerical Simulation of Scalar Transfer in Regular and Fractal Grid Turbulence

H. Suzuki, K. Nagata, Y. Sakai, T. Hayase

Bulletin of the International Conference "Turbulent Mixing and Beyond"　107-108　2009/08
Pulse wave velocity(PWV)とCardio Ankle Vascular Index(CAVI) 数理モデルから臨床,予防医学への展開－

山家智之, 白石泰之, 金野敏, 劉紅箭, 川島隆太, 吉澤誠, 早瀬敏幸, 阿部恒之, ビクター・ミラーゲン, ユーリ・コバレフ, イリーナ・ミリャジーナ, 候暁彫, 張秀敏

日本臨床生理学会雑誌　39　(4)　189-213　2009/08

ISSN： 0286-7052
医療計測と数値シミュレーションを融合した血管内血流の解析

船本健一, 早瀬敏幸

日本可視化情報学会誌　29　(114)　20-26　2009/07
Publisher: 社団法人可視化情報学会
DNS of Passive Scalar Field with Mean Gradient in Fractal-Generated Turbulence Peer-reviewed

H. Suzuki, K. Nagata, Y. Sakai, T. Hayase, T. Kubo

Proc. of the 6th International Symposium on Turbulence and Shear Flow Phenomena　1　55-60　2009/06
計測融合シミュレーションによる血流解析

船本健一, 早瀬敏幸

日本機械学会流体工学部門ニューズレター流れ　2009/04
539 Development of Poly (Vinyl Alcohol) Gel with in vivo Acoustic Properties

YAMASHITA Osamu, FUNAMOTO Kenichi, HAYASE Toshiyuki

2008　(21)　451-452　2009/01/22
Publisher: The Japan Society of Mechanical Engineers
127 Effect of Curved Pipe Movement due to Flow Force on the Pulsatile Flow Inside

INOUE Kosuke, HAYASE Toshiyuki

2008　(21)　285-286　2009/01/22
Publisher: The Japan Society of Mechanical Engineers
326 Blood Flow Simulation Integrated with Ultrasonic Measurement 8th Report : Effect of Error in Ultrasonic Measurement

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

2008　(21)　353-354　2009/01/22
Publisher: The Japan Society of Mechanical Engineers
130 Effect of Vertical Distribution of Shear Stress Generated by Flow or Centrifugal Force on Orientation of Cultured Endothelial Cells

SAITO Manabu, HAYASE Toshiyuki, INOUE Kosuke, TAKEDA Motohiro

2008　(21)　291-292　2009/01/22
Publisher: The Japan Society of Mechanical Engineers
212 Measurement of Friction Characteristics of Neutrophil on Endothelial Cells with the Inclined Centrifuge Microscope

UMIMOTO Takashi, SHIRAI Atsushi, HAYASE Toshiyuki

2008　(21)　81-82　2009/01/22
Publisher: The Japan Society of Mechanical Engineers
327 Evaluation of Mechanical Properties of Poly (vinyl alcohol) Hydrogel for the Development of Blood Vessel Biomodeling

KOSUKEGAWA Hiroyuki, MAMADA Keisuke, LIU Lei, KUROKI Kanju, INOUE Kosuke, HAYASE Toshiyuki, OHTA Makoto

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2008　(0)　355-356　2009
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2008.21.355 　
Direct Numerical Simulation of Turbulence Characteristics Generated by Fractal Grids Peer-reviewed

K. Nagata, H. Suzuki, Y. Sakai, T. Hayase, T. Kubo

International Review of Physics　2　(6)　400-409　2008/12
DNS of Spatially Developing Fractal-Generated Turbulence

H. Suzuki, K. Nagata, Y. Sakai, T. Hayase, T. Kubo

Proc. of the 7th JSME-KSME Thermal and Fluids Engineering Conference　CDROM　3 pages　2008/10
B406 Development of Material with Acoustic Property Close to Anatomy : Measurement System

YAMASHITA Osamu, FUNAMOTO Kenichi, HAYASE Toshiyuki

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2008　(19)　141-142　2008/09/22
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
B206 Numerical Experiment of MR-Measurement-Integrated Simulation of Unsteady Blood Flow in a Cerebral Aneurysm

FUNAMOTO Kenichi, SUZUKI Yoshitsugu, HAYASE Toshiyuki, KOSUGI Takashi, ISODA Haruo

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2008　(19)　52-53　2008/09/22
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
A316 Measurement of Friction Characteristics of Neutrophil on MPC polymer with an Inclined Centrifuge Microscope

UMIMOTO Takashi, SHIRAI Atsushi, HAYASE Toshiyuki

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2008　(19)　111-112　2008/09/22
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
計測融合シミュレーションによる流れ解析

早瀬敏幸

フルードパワーシステム　39　(4)　220-224　2008/07
A107 Transport phenomena of macro and micro flows behind orifice and flow accelerated corrosion

FUJISAWA Nobuyuki, HAYASE Toshiyuki, OHARA Taku, IKOHAGI Toshiaki

National Symposium on Power and Energy Systems　2008　(13)　15-16　2008/06/18
Publisher: The Japan Society of Mechanical Engineers

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This paper describes experiment and numerical simulations for macro and micro flows behind an orifice model in a square pipe, which are carried from the viewpoint of flow accelerated corrosion (FAC). The measurements of velocity field behind the orifice model were carried out using particle image velocimetry, and the variations of velocity field with respect to the accuracy of the orifice position were studied. It is found that the reattachment behavior of the flow is highly influenced by the orifice position, which is a critical problem for predicting the pipe thinning phenomena by FAC. The DNS simulation was also conducted for calculating the macro flow behind the orifice. The result suggests that the DNS simulation is applicable to the prediction of pipe thinning macro flow for highly aged nuclear plant. The micro flow simulation can predict the pipe thinning phenomena near the wall.
NUMERICAL EXPERIMENT OF MR-MEASUREMENT-INTEGRATED SIMULATION OF STEADY BLOOD FLOW IN A CEREBRAL ANEURYSM

FUNAMOTO Kenichi, SUZUKI Yoshitsugu, HAYASE Toshiyuki, KOSUGI Takashi, ISODA Haruo

Proceedings of the conference on computational engineering and science　13　(2)　547-550　2008/05/19
Publisher: 日本計算工学会
ISSN： 1342-145X
Visualization of blood flow field by ultrasonic-measurement-integrated simulation

FUNAMOTO Kenichi, HAYASE Toshiyuki, LIU Lei, OGASAWARA Masafumi, JIBIKI Takao, HASHIMOTO Hiroshi, MIYAMA Koji

35　S254　2008/04/15

ISSN： 1346-1176
Carotid artery phantom using PVA-H (Poly vinyl alcohol hydro gel) for ultrasonic measurement and visualization

LIU Lei, HAYASE Toshiyuki, FUNAMOTO Kenichi, OGASAWARA Masafumi, JIBIKI Takao, HASHIMOTO Hiroshi, MIYAMA Kouji

35　S311　2008/04/15

ISSN： 1346-1176
314 Direct Numerical Simulation of the Effects of External Turbulence on Turbulence Structure and Heat Transfer in a Turbulent Boundary Layer

SUZUKI Hiroki, NAGATA Kouji, SAKAI Yasuhiko, HAYASE Toshiyuki, KUBO Takashi

2008　(57)　211-212　2008/03/01
Publisher: The Japan Society of Mechanical Engineers
132 Ultrasonic-Measurement-Integrated Simulation on Laminar Flow in a Straight Tube : Three-Dimensional Analysis Using Non-Axisymmetric Feedback Law

FUNAMOTO Kenichi, LIU Lei, HAYASE Toshiyuki

2007　(20)　271-272　2008/01/24
Publisher: The Japan Society of Mechanical Engineers
131 Ultrasonic-Measurement-Integrated Simulation on Laminar Flow in a Straight Tube : Axisymmetric Analysis Using Axisymmetric Feedback Law

LIU Lei, FUNAMOTO Kenichi, HAYASE Toshiyuki

2007　(20)　269-270　2008/01/24
Publisher: The Japan Society of Mechanical Engineers
116 Development of Three-Dimensional Blood Vessel Image Acquiring System With Ultrasonic Diagnostic Equipment

TAKEUCHI Kosuke, INOUE Kosuke, HAYASE Toshiyuki

2007　(20)　31-32　2008/01/24
Publisher: The Japan Society of Mechanical Engineers
115 Numerical Simulation of Blood Flow in Left Atrium Modeled with Magnetic Resonance Imaging

KANKE Yusuke, HAYASE Toshiyuki, YAMBE Tomoyuki, SHIBATA Muneichi, SHIRAISHI Yasuyuki

2007　(20)　29-30　2008/01/24
Publisher: The Japan Society of Mechanical Engineers
111 Friction Characteristics of Red Blood Cells under Physiological Temperature Condition Measured with an Inclined Centrifuge Microscope

HAGANUMA Tomomi, HAYASE Toshiyuki, Inoue Kosuke, Takeda Motohiro

2007　(20)　21-22　2008/01/24
Publisher: The Japan Society of Mechanical Engineers
Characteristics of Turbulent Heat Transfer in Fractal Grid Turbulence

SUZUKI Hiroki, NAGATA Kouji, SAKAI Yasuhiko, HAYASE Toshiyuki, KUBO Takashi

2008　200-200　2008
Publisher: 日本流体力学会

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Experimental studies on the turbulence generated by 'fractal grids' have been done by Hurst & Vassilicos (2007) and Seoud & Vassilicos (2007). In this study, turbulence structure and passive scalar field in the spatially developing fractal generated turbulence are investigated by means of the direct numerical simulation (DNS). The results show that fractal grid produces higher Reynolds number flow compared with a classical grid turbulence using a biplane square grid, as observed in the previous experiments. The scalar field shows that larger temperature fluctuations are generated in the fractal grid turbulence compared with a classical grid turbulence.
B408 Fabrication of Anisotropic Vessel Model Using PVA-H and Mesh Materials

LIU Lei, KOSUKEGAWA Hiroyuki, OHTA Makoto, HAYASE Toshiyuki

The Proceedings of the JSME Conference on Frontiers in Bioengineering　2008　(0)　145-146　2008
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebiofro.2008.19.145 　

ISSN： 1348-2939
1003 Direct Numerical Simulation of the Effects of Grid-Generated Turbulence on Turbulence Structure and Heat Transfer in the Turbulent Boundary Layer(2)

SUZUKI Hiroki, NAGATA Kouji, SAKAI Yasuhiko, HAYASE Toshiyuki, KUBO Takashi

Fluids engineering conference ...　2007　"1003-1"-"1003-4"　2007/11/17
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882

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The effects of external grid turbulence in a free stream on the turbulent boundary layer are investigated by means of the direct numerical simulation (DNS). A square turbulence-generating-grid, on which the velocity and components are set to zero, is located at a short distance downstream of the front edge of the flat boundary with a nonslip condition. The fractional step method is used to solve the governing equations. The results show that turbulence intensities, Reynolds stress, and heat flux normalized by the inner parameters are suppressed in the log-law region by the external grid turbulence.
A212 Accuracy Verification of Ultrasonic Measurement for Ultrasonic-Measurement-Integrated Simulation Using PVA-H Straight Tube Model

LIU Lei, HAYASE Toshiyuki

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2007　(18)　99-100　2007/10/05
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
機械工学年鑑ミクロスケールの流れ

Toshiyuki Hayase

日本機械学会誌　110　(1065)　594-595　2007/08/05
Publisher: 一般社団法人日本機械学会
ISSN： 0021-4728
Direct Numerical Simulation of the Convective Boundary Layer with External Grid Turbulence Peer-reviewed

H. Suzuki, K. Nagata, Y. Sakai, T. Hayase, T. Kubo

Proc. of the 18th International Symposium on Transport Phenomena　1957-1961　2007/08
力学特性を付与した脳動脈瘤モデル開発のためのPoly(vinyl alcohol)hydro‐gelの物性評価

小助川博之, 間々田圭祐, 劉磊, 黒木完樹, 早瀬敏幸, 太田信

日本バイオレオロジー学会年会プログラム・抄録集　30th　69　2007/06/06
(1)Transit Characteristics of a Neutrophil Passing through Two Moderate Constrictions in a Cylindrical Capillary Vessel : Effect of Cell Deformation on Transit through the Second Constriction

Journal of the Japan Society of Mechanical Engineers　110　(1062)　339-339　2007/05/05
Publisher: The Japan Society of Mechanical Engineers
ISSN： 0021-4728
157 Measurement of fluid velocity of blood cell in microchannel with observation system

ASAHINA Sho, SHIRAI Atsushi, HAYASE Toshiyuki

2007　(42)　113-114　2007/03/13
Publisher: The Japan Society of Mechanical Engineers
191 Basic Examination of Eigenvalue Analysis for Measurement-Integrated Simulation

Imagawa Kentaro, Hayase Toshiyuki

2007　(42)　179-180　2007/03/13
Publisher: The Japan Society of Mechanical Engineers
309 Blood Flow Simulation Integrated with Ultrasonic Measurement : 7^<th> Report: Effect of Time Resolution of Measurement

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

2006　(19)　68-69　2007/01/06
Publisher: The Japan Society of Mechanical Engineers
Direct Numerical Simulation of the Effects of Grid-Generated Turbulence on the Turbulent Boundary Layer

SUZUKI Hiroki, NAGATA Kouji, SAKAI Yasuhiko, HAYASE Toshiyuki, KUBO Takashi

2007　59-59　2007
Publisher: 日本流体力学会

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The effects of external grid turbulence in a free stream on the turbulent boundary layer are investigated by means of the direct numerical simulation (DNS). A square grid-generated turbulence, on which the velocity components are set to zero, is located at a short distance downstream of the front edge of the flat boundary with a nonslip condition. The fractional step method is used to solve the governing equations. The results show that turbulence intensities and Reynolds stress normalized by the inner parameters are suppressed in the log-law region by the external grid turbulence.
310 Method of Determining Unsteady Blood Flow Rate Condition in Ultrasonic-Measurement-Integrated Simulation

YAMAGATA Takayuki, HAYASE Toshiyuki

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2006　(0)　70-71　2007
Publisher: The Japan Society of Mechanical Engineers
G603 Three-Dimensional Analysis of Karman Vortex Street Behind a Square Cylinder by Hybrid Wind Tunnel

YAMAGATA Takayuki, HAYASE Toshiyuki

The Proceedings of the Fluids engineering conference　2007　(0)　_G603-1_-_G603-4_　2007
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882

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This study deals with the hybrid wind tunnel which combines wind tunnel experiment and numerical simulation to obtain the exact and detailed information of real flows. The hybrid wind tunnel based on the observer theory utilizes partial information of the real flow from pressure measurement for the numerical simulation through a feedback loop to overcome the difficulty of specifying exact boundary or initial conditions as well as the effect of modeling error. In previous two-dimensional analyses on the hybrid wind tunnel, the difference between computation and experiment in regard to perturbation velocity increased with the computational grid of a high resolution due to the inappropriateness of the two-dimensional model. In this paper, three-dimensional analyses with three grid systems of different resolutions are performed on the hybrid wind tunnel for a fundamental flow with the Karman vortex street behind a square cylinder. The reproducibility of a velocity field on the hybrid wind tunnel is improved in three-dimensional analysis by using the high resolution grid system. In addition, three-dimensional analysis with the coarse grid system on the hybrid wind tunnel effectively reduces the error due to the insufficient grid resolution for ordinary numerical simulation.
自動車周りの気流制御

仁杉圭延, 早瀬敏幸

フルードパワーシステム　38　(1)　52-55　2007/01
B110 Development of observation System of Neutrophils Transit in Microchannel : Prevention of Adhesion of the Cells on Microchannel by MPC Coating

ASAHINA Sho, SHIRAI Atsushi, HAYASE Toshiyuki

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2006　(17)　59-60　2006/11/10
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
B109 Comparison of frictional characteristics of red blood cells on various substrates measured with inclined centrifuge microscope

Kandori Takashi, Haganuma Tomomi, Inoue Kousuke, Hayase Toshiyuki, Takeda motohiro

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2006　(17)　57-58　2006/11/10
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
818 Effect of Mechanical Properties of Neutrophils on Their Transit Time through a Capillary Network(2)

SHIRAI Atsushi, HAYASE Toshiyuki

Fluids engineering conference ...　2006　"818-1"-"818-4"　2006/10/28
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882

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It is known that neutrophils are retained in pulmonary microvasculature causing higher concentration than in large systemic vessels. Neutrophils have to undergo large deformation in passing through the narrow capillaries, and their low deformability is thought to lead the long-term retention in the pulmonary capillaries. In this research, the authors numerically investigated the passage of the cells through a narrow capillary network for three levels of the cell stiffness. It was shown that transit time of the cells through the network was not proportion to the cell stiffness, that is, the transit time did not increase as much as the increase in the cell stiffness. Then, the authors analytically investigated the effect of the cell stiffness on the transit time of a cell through the network from a mathematical model to predict the transit time of a cell through a single capillary segment.
1305 Numerical Experiment of Reproduction of Turbulent Flow in Square Duct with Measurement-Integrated Simulation : Reduction of Feedback Points by Considering Influence Area of Feedback(2)

Imagawa K., Hayase T.

Fluids engineering conference ...　2006　"1305-1"-"1305-4"　2006/10/28
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882

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A measurement-integrated simulation (MI simulation) is a SIMPLER-based flow simulation scheme modified by adding a feedback signal proportional to the difference between the simulation and the real flow. MI simulation has been in practical use, however, a general theory of MI simulation has not been established. In this study, numerical experiment was performed for MI simulation of turbulent flow in a square duct to obtain fundamental knowledge in constructing a general theory. MI simulation applying feedback at one grid point revealed that the effect of feedback propagates sharply in the downstream direction. As a result, MI simulation applying feedback at the grid points on every twentieth plane in the x_1 direction still reduces the error by a factor on the order of 10^<-4> at some feedback gain, while MI simulation with the feedback on the planes skipped in the x_2 direction requires ten times more planes to achieve the same reduction rate.
1306 Numerical Experiment of Ultrasonic-Measurement-Integrated Simulation for Three-Dimensional Unsteady Blood Flow(1)

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

Fluids engineering conference ...　2006　"1306-a"　2006/10/28
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882
Ultrasonic-Measurement-Integrated Blood Flow Simulation

Toshiyuki Hayase

フルードパワーシステム　37　(5)　302-305　2006/09
Reproduction of Real Flows by Integrating Measurement and Simulation

Toshiyuki Hayase

日本応用数理学会誌　16　(1)　78-84　2006/03
Publisher: The Japan Society for Industrial and Applied Mathematics
DOI： 10.11540/bjsiam.16.1_78 　

ISSN： 0917-2270
Real-Time Reproduction of Pressure and Velocity Fields of Complex Flows

Toshiyuki Hayase

Inspection Engineering　11　(2)　12-16　2006/02
Publisher: 日本工業出版
21 COE artificial organ project using regenerative medicine and nano technology : In artificial internal organs, smaller is better. And an important issue is bio affinity. From these points of view, Regenerative medicine and Nano technology are very useful technology. In Tohoku University, various artificial internal organ research including Artificial esophagus, Artificial Myocardium, and Artificial sphincter based on 21 COE program. Ideal artificial organs may be embodied in future

YAMBE Tomoyuki, HORI Yoshio, SHIRAISHI Yasuyuki, SEKINE Kazumitsu, IGUCHI Atsushi, TABAYASHI Kouichi, HAGA Youichi, ESASHI Masayoshi, YOSHIZAWA Makoto, TANAKA Akira, MATSUKI Hidetoshi, SATO Fumihiro, KAWANO Satoyuki, LUO Yun, HIGA Masaru, TAKAGI Toshiyuki, HAYASE Toshiyuki, MARUYAMA Shigenao, WANG Quintian, DHUANG Kyokuto, NITTA Shinichi, IMACHI Kou, SASADA Hiroshi, SATO Eimei, SATO Masaaki, OKAMOTO Eiji, KUBO Yutaka, OSAKA Motohisa, UMETSU Mitsuo, HONMA Dai, MAEDA Takeshi

Ensho Saisei　26　(1)　35-39　2006/01/25
Publisher: The Japanese Society of Inflammation and Regeneration
DOI： 10.2492/jsir.26.35 　

ISSN： 1346-8022

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In artificial internal organs, smaller is better. And an important issue is bio affinity. From these points of view, Regenerative medicine and Nano technology are very useful technology. In Tohoku University, various artificial internal organ research including Artificial esophagus, Artificial Myocardium, and Artificial sphincter based on 21 COE program. Ideal artificial organs may be embodied in future.
At the Issue of "Worldwide Research Trend Appearing in Sixth JFPS International Symposium on Fluid Power, Tsukuba 2005"

HAYASE Toshiyuki

37　(1)　12-12　2006/01/15

ISSN： 1346-7719
223 Effect of Anisotropic Feedback Points Arrangement in Three-dimensional Ultrasonic-Measurement-Integrated Simulation

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

2005　(18)　105-106　2006/01/12
Publisher: The Japan Society of Mechanical Engineers
カルマン渦列計測融合シミュレーションの臨界点情報を用いたリアルタイム可視化

竹島由里子, 柴田光, 高橋成雄, 藤代一成, 早瀬敏幸

画像電子学会Visual Computing情報処理学会グラフィクスとCAD研究会合同シンポジウム　263-266　2006

DOI： 10.11371/aiieej.34vc.0.263.0 　
1304 Validation of Real-Time Analysis of Karman Vortex Street Using Hybrid Wind Tunnel(2)

YAMAGATA Takayuki, Shibata Hikaru, SMIT Kasper, HAYASE Toshiyuki

The Proceedings of the Fluids engineering conference　2006　(0)　_1304-1_-_1304-4_　2006
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882

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Numerical simulation and experiment are important tools in flow analysis, but they have advantages and disadvantages. We have proposed Measurement-Integrated simulation that integrates numerical simulation and measurement to reproduce the real flows. This new methodology reproduced the velocity field of Karman vortex street behind a square cylinder in far better agreement with the real flow than the ordinary simulation. In this paper, the pressure field obtained by the MI simulation is validated in comparison with pressure measurement on the sidewall of the wind tunnel. Results show the MI simulation successfully reproduces the pressure oscillation near the cylinder although the root-mean-square pressure is degraded in the downstream region. In addition, the pressure field of Karman vortex street is analyzed and visualized in real-time using the hybrid wind tunnel.
1307 Numerical Experiment and Experimental Application of Ultrasonic-Measurement Integrated-Simulation with PVA Straight Pipe Model(2)

LIU Lei, INOUE Kosuke, HAYASE Toshiyuki, OHTA Makoto

The Proceedings of the Fluids engineering conference　2006　(0)　_1307-1_-_1307-4_　2006
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmefed.2006._1307-1_ 　

ISSN： 1348-2882

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Thoracic aortic dissection has a high fatality rate, and the number of fatalities has tendency to increase with advancing age. Because of our fast-aging society, it is a problem calling for immediate solution. It is difficult to recognize the exact structure of the 3D blood flow with measurement existing. Besides, because we cannot set precise boundary condition of living body, computer simulation is not a complete tool to analyze real blood flows. Our research group had propounded a new solution, integrating together ultrasonic-measurement and CFD to investigate blood flows, which is called Ultrasonic-Measurement-Integrated (UMI) Simulation. Usability of UMI simulation has been confirmed by numerical experiment in former studies. In this report, experimental system consisting of a PVA hydro-gel straight pipe model and constant head flow tank was developed, and fundamental experiment to confirm the performance of the ultrasound measurement device was performed. In parallel with experiment, a numerical experiment with axisymmetric straight pipe model was performed. In this report, we confirmed characteristics of the ultrasound measurement to the PVA model in experiment and usability of the UMI simulation in numerical experiment.
B210 Numerical Analysis for Increase in Concentration of Neutrophils in Capillary Network

SHIRAI Atsushi, HAYASE Toshiyuki

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2005　(16)　147-148　2005/11/08
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
B205 Blood Flow Simulation Integrated with Ultrasonic Measurement : 5^<th> Report: Reproduction of Three-dimensional Unsteady Blood Flow Field

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2005　(16)　137-138　2005/11/08
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
903 Numerical Experiment of Reproduction of Turbulent Flow in Square Duct with Measurement-Integrated Simulation

Imagawa K., Hayase T.

Fluids engineering conference ...　2005　135-135　2005/10/28
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882
902 Verification of Reproducibility of Pressure Field in Analysis of Karman Vortex Street with Hybrid Wind Tunnel

SHIBATA Hikaru, HAYASE Toshiyuki, SATO Yutaka

Fluids engineering conference ...　2005　134-134　2005/10/28
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882
907 Evaluation of Effectiveness of Feedback Formulae in Three-dimensional Ultrasonic-Measurement-Integrated Simulation of Blood Flow

Funamoto Kenichi, Hayase Toshiyuki, Saijo Yoshifumi, Yambe Tomoyuki

Fluids engineering conference ...　2005　139-139　2005/10/28
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882
【消化管とナノテクノロジー医療】ナノバイオマテリアルを応用した人工食道の開発 (G.I.Research)

山家智之, 堀義生, 渡辺誠, 白石泰之, 井口篤志, 田林晄一, 芳賀洋一, 江刺正喜, 吉澤誠, 田中明, 松木英敏, 佐藤文博, 川野恭之, 羅雲, 高木敏行, 早瀬敏幸, 圓山重直, 仁田新一, 佐々田比呂志, 佐藤英明, 本間大, 前田剛

G.I.Research　13　(4)　271-276　2005/08
複雑な流れをリアルタイムで再現する計測融合シミュレーション技術

早瀬敏幸

原子力eye　51　(8)　66-69　2005/08
Publisher: 日刊工業出版プロダクション
ISSN： 1343-3563
AM05-17-022 Numerical Simulation for Concentration Distribution of Neutrophils in Caoillary Network

SHIRAI Atsushi, HAYASE Toshiyuki

2005　313-313　2005
Publisher: 日本流体力学会

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Concentration of neutrophils in pulmonary microvasculature is higher than in systemic circulation even in normal lungs. Authors presented a simulation model for the flow of neutrophils through a capillary network to show the effects of segment geometry and cell stiffness on the distribution of transit time of the cells through the network. In this research, spatial distribution of the cells in a lattice capillary network was investigated with various segment geometry, cell stiffness and flow condition. Consequently, it was found that distribution of number of cell passage through individual capillary segment was not always symmetric. Even if the time integrated distribution was symmetric, it could be the result of alternatively changed deviated cell passage.
AM05-17-010 Effect of Feedback Points Arrangement on Accuracy of Three-dimensional Ultrasonic-Measurement-Integrated Simulation of Blood Flow

Funamoto Kenichi, Hayase Toshiyuki, Saijo Yoshifumi, Yambe Tomoyuki

2005　226-226　2005
Publisher: 日本流体力学会

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We have developed Ultrasonic-Measurement-Integrated (UMI) simulation to obtain detailed and accurate information of blood flow field numerically for the diagnosis or treatment of aneurysms. In this methodology, feedback signals derived from the difference between Doppler velocities by measurement and computation are fed back to the numerical simulation. In this study, we investigate the effect of feedback point arrangement on the computational accuracy of three-dimensional UMI simulation by numerical analysis. The result of UMI simulation converges to the standard solution in the feedback domain and in some extent of the downstream region of the feedback domain. The computational accuracy is more improved as the increment of feedback point density, while the necessary computational time for convergence is unchanged.
AM05-17-012 Frictional Characteristics of Red Blood Cells moving on DLC-Coated Plate

Kandori Takashi, Inoue Kousuke, Hayase Toshiyuki, Takagi Toshiyuki

2005　228-228　2005
Publisher: 日本流体力学会

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Recently, DLC (Diamond-Like amorphous Carbon, DLC) film attracted considerable attention as a coating material in medical applications because of low coefficient of friction and excellent biocompatibility. The present paper focuses on the frictional characteristics of DLC coated glass plate with respect to individual red blood cells sliding on the plate in plasma. Experiment was performed for a DLC coated and a plane glass plate with an inclined centrifuge microscope. In observation of cells' motion, tendency of cell clustering was reduced on the DLC coated glass in comparison with the plane glass plate. There exists no difference between the mean cell velocity on the both plates in a small frictional force range. But further study is needed for a large frictional force range.
1109 Development of Ultrasonic-Measurement-Integrated Blood Flow Simulation System : Automatic Adjustment of Parameters

YAMAGATA Takayuki, HAYASE Toshiyuki

The proceedings of the JSME annual meeting　2005　(0)　91-92　2005
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemecjo.2005.5.0_91 　

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Detailed information of the velocity and pressure field of the blood flow is essential to establish an advanced diagnosis and treatment of serious circulatory diseases. Commonly used medical measurement equipments does not provide complete information of blood flow in real-time. In this report, we develop a new blood flow measurement system applying Ultrasonic- Measurement-Integrated (UMI) simulation, that integrates ultrasonography and numerical simulation. The system consists of ultrasonic diagnostic imaging equipment, a graphics workstation, and a calculation server. Computer programs for measurement data acquisition, flow simulation, and visualization are synchronized using socket communication scheme. By considering blood flow velocity measured, the system adjusted the phase of a flow rate waveform automatically to match the cycle of pulsation in real diagnostic images.
906 Automatic Adjustment of Flow Rate in Ultrasonic-Measurement-Integrated Blood Flow Simulation System

YAMAGATA Takayuki, HAYASE Toshiyuki

The Proceedings of the Fluids engineering conference　2005　(0)　138-138　2005
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882
AM05-17-011 Experimental Apparatus to Simulate Blood Flow in Aorta for Validation of Ultrasonic-Measurement-Integrated Simulation

LIU Lei, Inoue KOSUKE, HAYASE Toshiyuki, OHTA Makoto

日本流体力学会年会講演論文集　2005　227-227　2005
Publisher: 日本流体力学会

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Thoracic aortic dissection has a high fatality rate, and the number of fatalities is tendency to increase with advancing age. Because of our fast-aging society, it's a problem calling for immediate solution. It's difficult to recognize the exact structure of the 3D blood flow with measurement existing, and that makes having an elucidation of mechanism adversity. Our research group had propounded a new solution; integrate together ultrasonic-measurement and CFD to investigate blood flow, which is called Ultrasonic-Measurement-Integrated (UMI) Simulation. Usability of UMI simulation has been confirmed by numerical experiment in former studies. In this paper,_<in-vitro> system for fluid flow experiment to verify UMI simulation was fabricated and pilot study was performed. Thoracic aneurysm models in this system, based on CT scan data and duplicated its original configuration precisely, were made of Silicone rubber and PVA-polymer. The letter models has elasticity like real vessels is a point worthy of special mention.
Bio-Fluids

HAYASE Toshiyuki, FUNAMOTO Kenichi

Fluids engineering conference ...　2004　201-201　2004/11/24
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882
Blood Flow Simulation Integrated with Ultrasonic Measurement 3^<rd> Report : Reproduction of Three-dimensional Blood Flow Field

FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2004　(15)　113-114　2004/11/04
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
流体シミュレーションと融合した高度流体計測手法の開発 (第21回センシングフォーラム資料--センシング技術の新たな展開と融合) -- (セッション1A1 高機能流速・流量センシング--流体計測部会企画OS)

早瀬敏幸, 船本健一

センシングフォ-ラム資料　21　3-6　2004/09/14
Publisher: 〔計測自動制御学会〕
ISSN： 1343-7631
Development of the Artificial Internal Organs by the Use of Nanotechnology -Artificial Esophagus and Artificial Myocardium-

Tomoyuki Yambe, Yoshio Hori, Yasuyuki Shiraishi, Atsushi Iguchi, Kouichi Tabayashi, Youichi Haga, Masayoshi Esashi, Makoto Yoshizawa, Akira Tanaka, Hidetoshi Matsuki, Fumihiro Sato, Satoyuki Kawano, Yun Luo, Toshiyuki Takagi, Toshiyuki Hayase, Shigenao Ma

ナノ学会会報　2　(2)　104-112　2004/02
Oscillation in Side Branch at Right-Angle Branch along the Separation Region

Shimane Johji, Kudo Susumu, Hayase Toshiyuki, Yamaguchi Ryuhei

2004　(16)　227-228　2004/01/21
Publisher: The Japan Society of Mechanical Engineers
Ultrasonic-Measurement-Integrated Simulation for Blood Flows 2^<nd> Report : Reproduction of Blood Flow in Aorta

FUNAMOTO Kenichi, HAYASE Toshiyuki, SHIRAI Atsushi, YAMBE Tomoyuki, SAIJO Yoshifumi

2004　(16)　165-166　2004/01/21
Publisher: The Japan Society of Mechanical Engineers
Time Variation of the Maximum Radius of a Deformed Neutrophil that has Passed through a Narrow Capillary

SHIRAI Atsushi, FUJITA Ryo, HAYASE Toshiyuki

2004　(16)　179-180　2004/01/21
Publisher: The Japan Society of Mechanical Engineers
B324 Study of Feedback Law for Ultrasonic-Measurement-Integrated Simulation of Blood Flow

FUNAMOTO Kenichi, HAYASE Toshiyuki, SHIRAI Atsushi, SAIJO Yoshifumi, YAMBE Tomoyuki

2004　538-539　2004
Publisher: 日本流体力学会

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In order to reproduce the blood velocity and pressure fields of the blood flow for an accurate diagnosis or treatment for serious circulatory diseases such as aortic aneurysms, we integrate color Doppler ultrasonography and numerical simulation. We term this method as Ultrasonic-Measurement-Integrated (UMI) simulation. In the UMI simulation, feedback signals are added to the governing equations to compensate for the difference between computation and measurement. In this paper, we investigate effects of feedback law of the UMI simulation, such as feedback formulae, number and arrangement of monitoring points and the direction of ultrasonic beam for acquisition of Doppler velocity data, on the accuracy of the UMI simulation and computational time. It is revealed that the result of UMI simulation in the feedback domain rapidly converges to the standard solution, even with inevitably incorrect upstream boundary conditions.
B323 Numerical Simulation of Neutrophils Flow in Capillary Network

SHIRAI Atsushi, FUJITA Ryo, HAYASE Toshiyuki

2004　536-537　2004
Publisher: 日本流体力学会

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Neutrophils retain in pulmonary capillaries in normal lungs, causing 40- to 80-fold greater concentration than in systemic large vessels. The highly concentrated neutrophils are thought to be effectively recruited to inflammations, and thus, it is essential to know how neutrophils flow in pulmonary capillaries for the understanding of immune system in lungs. Authors have developed a simple mathematical model to predict the transit time of a neutrophil passing through a capillary segment to investigate the flow characteristics of neutrophils in pulmonary capillary bed. In this research, numerical simulation model is developed to obtain the distribution of transit times of the cells through a capillary network based on the mathematical model obtained in the previous research. This paper introduces the detail of the simulation model and shows an example of the numerical result.
計測と融合した流体シミュレーションの新展開

早瀬敏幸

平成16年春季フルードパワーシステム講演会講演論文集　27　2004
B322 Measurement of Frictional Characteristics of Cells Using Inclined Centrifuge Microscope

HAYASE Toshiyuki, SAITO Kotomi, YAMAGATA Takayuki, INOUE Kosuke, SHIRAI Atsushi

日本流体力学会年会講演論文集　2004　534-535　2004
Publisher: 日本流体力学会

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In order to understand precise frictional characteristics of the red blood cells in blood capillaries, the inclined centrifuge microscope has been developed, and the frictional characteristics of blood cells on a glass plate were measured as the first step. In that research, it was the subject of discussion whether the cells glide or roll on the glass plate since the resolution of the microscope was not sufficient to distinguish the cell motion. This report deals with improvement of the observation technique for cell motion. The magnification of the inclined centrifuge microscope is increased by 5 times. The shape of red blood cells under movement can be seen clearly and cells seem to glide on the glass plate, although it is still difficult to exclude the possibility of cell rolling.
ナノテク集積型埋め込み式寝室補助装置

山家智之, 仁田新一, 江刺正喜, 芳賀洋一, 吉澤誠, 田中明, 岡本英治, 円山重直, 早瀬敏幸, 高木敏行, 羅雲, 松本英敏, 佐藤文博, 福田寛, 田林晄一, 西條芳文, 飯島俊彦, 大阪元久, 久保豊, 川野聡恭, 梅津光生, 堀義生, 紺野能史, 山内清, 山口健二

平成14－15年度研究報告書　35-38　2004
ナノテクを応用した人工臓器開発の新しい地平

山家智之, 堀義生, 白石泰之, 井口篤志, 田林晄一, 芳賀洋一, 江刺正喜, 吉澤誠, 田中明, 松木英敏, 佐藤文博, 川野恭之, 羅雲, 高木敏行, 早瀬敏幸, 圓山重直, 王慶田, 段旭東, 仁田新一, 井街宏, 佐々田比呂志, 佐藤英明, 岡本英治, 久保豊, 大坂元久, 梅津光生, 本間大, 前田剛

月刊未来材料　4　(8)　30-37　2004
東北大学における産学連携の体制と事例・成果・期待

Toshiyuki Hayase

油空圧技術　42　(11)　8-12　2003/10
Publisher: 日本工業出版
ISSN： 0914-6253
Improvement of Accuracy of Measurement for Frictional Characteristics of Red Blood Cells with Inclined Centrifuge Microscope by Image Processing Technique

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2003　(14)　27-28　2003/09/17
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
Flow Structure and Periodical Oscillation in side branch in Right Angle Branch

Amagai Hideaki, Yamaguchi Ryuhei, Kudo Susumu, Hayase Toshiyuki

2003　(15)　381-382　2003/01/20
Publisher: The Japan Society of Mechanical Engineers
Flow Analysis of the circumference of the Renal Artery Branch Pipe by Using PIV

Usui Hideaki, Kaneya Mamoru, Kudo Susumu, Yamaguti Ryuhei, Hayase Toshiyuki

2003　(15)　379-380　2003/01/20
Publisher: The Japan Society of Mechanical Engineers
Ultrasonic-Measurement-Integrated Simulation for Blood Flows : 1^<st> Report : Reduction of Error Originating from Upstream Boundary Condition

FUNAMOTO Kenichi, HAYASE Toshiyuki, SHIRAI Atsushi, YAMBE Tomoyuki, SAIJO Yoshifumi

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　1　83-84　2003
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
Three-Dimensional Analysis of Swimming Properties of Spiral-Type Magnetic Micro-Machines

YAMAZAKI A., SENDOH M., ISHIYAMA K., HAYASE T., ARAI K. I.

Journal of the Magnetics Society of Japan　27　(3)　142-145　2003
Publisher: The Magnetics Society of Japan
DOI： 10.3379/jmsjmag.27.142 　

ISSN： 0285-0192 1880-4004

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The basic equations of incompressible viscous fluid flow were integrated using the three-dimensional finite volume method. We calculated the flow field around the micro-machine was to estimate the swimming velocity, thrust, drag, and load torque of a spiral-type magnetic micro-machine. The swimming properties of the micro-machine were analyzed theoretically. We obtained good agreement was between the experimental and theoretical results, on which basis we judged a technique for three-dimensional analysis to be established.
ナノテク集積人工心筋開発プロジェクト

山家智之, 白石泰之, 井口篤志, 田林晄一, 芳賀洋一, 江刺正喜, 吉澤誠, 田中明, 松木英敏, 佐藤文博, 川野恭之, 羅雲, 高木敏行, 早瀬敏幸, 圓山重直, 王慶田, 段旭東, 仁田新一, 岡本英治, 久保豊, 大坂元久, 梅津光生

循環制御　24　(2)　111-117　2003

ISSN： 0389-1844
Issues of Future Simulation Technology for Fluid Power Systems

Toshiyuki Hayase

Fluid Power System　34　(1)　21-24　2003/01
SIMPLE Method

Toshiyuki Hayase

Fluid Power System　33　(7)　407-413　2002/11
Fundamental Study of Hybrid Wind Tunnel : Investigation of Realtime Analysis

NISUGI Keisuke, HAYASE Toshiyuki, SHIRAI Atsushi

2002　105-106　2002/09/06
Publisher: The Japan Society of Mechanical Engineers
Three-Dimensional Analysis of Swimming Properties of a Spiral-Type Magnetic Micro-Machine

YAMAZAKI A., SENDOH M., ISHIYAMA K., HAYASE T., ARAI K. I.

26　325-325　2002/09/01

ISSN： 1340-8100
Flow structure around branch point and periodical oscillation in side branch at right-angle branch

Ryuhei Yamaguchi, Susumu Kudo, Hideaki Amagai, Masaya Shigeta, Toshiyuki Hayase

Nippon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japan Society of Mechanical Engineers, Part B　68　(671)　2014-2019　2002/07

DOI： 10.1299/kikaib.68.2014 　

ISSN： 0387-5016
Fundamental Study on Hybrid Wind Tunnel : Investigation of Feedback Scheme

TAKEDA Shinpei, NISUGI Keisuke, SHIRAI Atsushi, HAYASE Toshiyuki

2002　(37)　32-33　2002/03/16
Publisher: The Japan Society of Mechanical Engineers
Numerical Simulation of Flow in Right Angle Branch : Mechanism of Unstable Oscillation

NAITO Taiki, HAYASE Toshiyuki, SHIRAI Atsushi, YAMAGUCHI Ryuhei

2002　(37)　44-45　2002/03/16
Publisher: The Japan Society of Mechanical Engineers
Cooperation with Industry in Tohoku University

HAYASE Toshiyuki

Journal of the Japan Fluid Power System Society　33　(2)　75-77　2002/03/15
Publisher: 日本フルードパワーシステム学会
ISSN： 1346-7719
Flow of Neutrophils through Two Constrictions in a Fine Capillary

SHIRAI Atsushi, FUJITA Ryo, HAYASE Toshiyuki

2002　(14)　133-134　2002/03/01
Publisher: The Japan Society of Mechanical Engineers
Error Evaluation and Monotonic Convergence in Numerical Simulation of Flow

Toshiyuki Hayase

ながれ　21　(1)　6-15　2002/02

DOI： 10.11426/nagare1982.21.6 　
Transit of a Deformed Neutrophil through a Constriction in a Fine Capillary : Effect of Throat Radius of Constriction on Transit Time

FUJITA Ryo, SHIRAI Atsushi, HAYASE Toshiyuki

2002　302-303　2002
Publisher: 日本流体力学会

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On the average, neutrophils are significantly less deformable than erythrocytes and, once they are deformed, they require considerable time to recover their initial spherical shape. For this reason, initial cell shape influences the transit time of neutrophils through capillary network. In this research, the flow of a neutrophil in a capillary with two constrictions was investigated numerically, in terms of the transit time of the cell through the second constriction after it had been deformed by passing through the first one.
Measurement of Frictional Characteristics of Red blood Cells in Small Velocity Regime with Inclined Centrifugal Microscope

SUGIYAMA Hidekatsu, HAYASE Toshiyuki, SHIRAI Atsushi, HAMAYA Tsuyoshi

2002　298-299　2002
Publisher: 日本流体力学会

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For understanding the interaction between blood cells, plasma and endothelial surface layer, we describe friction characteristics of red blood cells on the glass plate with inclined centrifugal force, especially in small velocity
Self-Excited Oscillation in Direct-Acting Poppet Valve Circuit : Influence of Column Separation

13　(2)　22-24　2001/11/01
Numerical Simulation and Virtual Measurement of Flow Fields

Toshiyuki Hayase

Journal of the Society of Instrument and Control Engineers　40　(11)　790-794　2001/11
Publisher: The Society of Instrument and Control Engineers
DOI： 10.11499/sicejl1962.40.790 　

ISSN： 0453-4662
308 Numerical Simulation of Flow in Right Angle Branch : Spatial Distribution of Unstable Oscillation

NAITO Taiki, HAYASE Toshiyuki, SHIRAI Atsushi, YAMAGUCHI Ryuhei

Fluids engineering conference ...　2001　39-39　2001/09/28
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882
309 Measurement of Flow Characteristics of Red Blood Cells with Inclined Centrifuge Microscope

HAYASE Toshiyuki, SUGIYAMA Hidekatsu, SHIRAI Atsushi, HAMAYA Tsuyoshi

Fluids engineering conference ...　2001　40-40　2001/09/28
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882
305 Numerical Analysis of Deformation of Neutrophils through Stenotic Capillaries

SHIRAI Atsushi, FUJITA Ryo, HAYASE Toshiyuki

Fluids engineering conference ...　2001　37-37　2001/09/28
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882
307 Wall Shear Stress and Periodical Oscillation in Side Branch in Right Angle Branch

AMAGAI Hideaki, SHIGETA Masaya, KUDO Susumu, YAMAGUCHI Ryuhei, HAYASE Toshiyuki

Fluids engineering conference ...　2001　38-38　2001/09/28
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882
G804 Fundamental Study on Hybrid Wind Tunnel : Evaluation of the Estimation Performance

TAKEDA Shinpei, NISUGI Keisuke, SHIRAI Atsushi, HAYASE Toshiyuki

Fluids engineering conference ...　2001　236-236　2001/09/28
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882
G803 Fundamental Study on Hybrid Wind Tunnel : Study of Feedback Scheme

NISUGI Keisuke, TAKEDA Shinpei, SHIRAI Atsushi, HAYASE Toshiyuki

Fluids engineering conference ...　2001　235-235　2001/09/28
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2882
Analysis of properties of miniature magnetic swimming machine

ISHIYAMA K., YAMAZAKI A., SENDOH M., HAYASE T., ARAI K. I.

2001　431-431　2001/09/21
Analysis of swimming properties of the miniature magnetic micromachine

YAMAZAKI A., SENDOH M., ISHIYAMA K., HAYASE T., ARAI K. I.

25　318-318　2001/09/01

ISSN： 1340-8100
Numerical Simulation of Flow in Right Angle Branch : Simulation in the Whole Region of Sharp Edged Branch

NAITO Taiki, HAYASE Toshiyuki, SHIRAI Atsushi, YAMAGUCHI Ryuhei

2001　(13)　76-77　2001/01/15
Publisher: The Japan Society of Mechanical Engineers
Measurement of Frictional Characteristics of a Red Blood Cell : Effect of Reaction

SAKASHITA Shigeto, SHIRAI Atsushi, HAMAYA Tsuyoshi, HAYASE Toshiyuki

2001　(13)　12-13　2001/01/15
Publisher: The Japan Society of Mechanical Engineers
A study on miniaturization of spiral-type magnetic micro-machine

SENDOH M., YAMAZAKI A, ISHIYAMA K., ARAI K. I., INOUE Mitsuteru, HAYASE Toshiyuki

2000　(283)　39-44　2000/12/07
Numerical Analysis of Flow Control Valve for Water Hydraulics

12　(2)　97-99　2000/10/01
血管分岐部流れの流体力学的安定性

Toshiyuki Hayase

Bio Medical Engineering　14　(10)　6-8　2000/10

DOI： 10.11239/jsmbe1987.14.10_6 　
Swimming of the magnetic micromachine in low Reynolds number

SENDOH M., YAMAZAKI A., ISHIYAMA K., INOUE M., HAYASE T., ARAI K. I.

24　349-349　2000/09/01

ISSN： 1340-8100
F09-(5) 機能流体システム

早瀬敏幸

年次大会資料集　2000　(5)　145-146　2000/07/31
Publisher: 一般社団法人日本機械学会
Swimming properties of the spiral-type magnetic micro-machines on high viscosity

YAMAZAKI A., SENDOH M., ISHIYAMA K., ARAI K. I., INOUE M., HAYASE T.

2000　(75)　13-18　2000/04/26
Education for Hydraulics & Pneumatics in Tohoku University

Toshiyuki Hayase

Journal of the Japan Hydraulics & Pneumatics Society　31　(2)　110　2000/03
非線形制御によりマイクロスティックスリップ振動を抑制した油圧サーボ系

Toshiyuki Hayase

機械設計　44　(2)　52-54　2000/01
Publisher: 日刊工業新聞社
ISSN： 0387-1045
機械的にコンプライアンス調整が可能な油圧サーボ系

Toshiyuki Hayase

機械設計　44　(2)　55-57　2000/01
Publisher: 日刊工業新聞社
ISSN： 0387-1045
乱流場のフィードバック制御 (SCFS'99「スーパーコンピューティングと計算流体科学」) -- (バーチャルリアリティデモンストレーション)

早瀬敏幸, 夏毓鵬, Humphrey J.A.C.

流体科学シンポジウム講演論文集　1999　57-60　1999/11
Publisher: 東北大学流体科学研究所
ISSN： 1344-2236
未来流体情報創造センターのスーパーコンピューターシステム紹介流体科学研究所におけるスーパーコンピュータシステムの導入 (SCFS'99「スーパーコンピューティングと計算流体科学」)

高木敏行, 早瀬敏幸, 小原拓

流体科学シンポジウム講演論文集　1999　69-73　1999/11
Publisher: 東北大学流体科学研究所
ISSN： 1344-2236
Eigenvalue Analysis and Non-Linear Phenomena of Direct-Acting Poppet Valve Circuit

11　(2)　3-4　1999/10/01
Drag Reduction of an Automobile by Feedback Control

11　(2)　102-103　1999/10/01
Effect of Discretization Scheme on Numerical Analysis of Flow through Spool Valve

11　(1)　115-117　1999/05
Stability of Direct-Acting Poppet Valve Circuit (Effect of Accumulator on Vibration of the Circuit)

11　(1)　70-72　1999/05
第4回油空圧国際シンポジウム

林叡, 早瀬敏幸

フルイドパワーシステム : 日本油空圧学会誌 : journal of the Japan Hydraulics & Pneumatics Society　30　(1)　37-38　1999/01/15

ISSN： 1343-4608
Effect of machine shape on swimming properties of the spiral-type magnetic micro machine

SENDOH M., AJIRO N., ISHIYAMA K., INOUE M., ARAI K. I., HAYASE T.

1998　(238)　1-6　1998/12/15
Numerical Simulation of Dynamic Characteristics of Water Hydraulic Relief Valve

10　(2)　16-18　1998/11/01
Two-dimensional analysis of properties of magnetic micro-machines by means of the finite volume method

SENDOH M., AJIRO N., INOUE M., ARAI K. I., HAYASE T.

22　421-421　1998/09/01
Numerical Experiment on Feedback Control of Turbulent Duct Flow with State Observer

HAYASE Toshiyuki

17　231-232　1998/07

ISSN： 1342-8004
Two-dimensional analysis of swimming properties of magnetic micro-machines by means of the finite volume method

SENDOH M., AJIRO N., INOUE M., ARAI K. I., HAYASE T.

1998　(39)　61-66　1998/06/11
Applicability of Lumped Parameter Pipeline Models on Direct-Acting Poppet Valve Circuit

10　(1)　31-33　1998/05
Fundamental Properties of Spiral-Type Magnetic Micro-Machines II

SHIMASAKI Katsuhiko, SENDOH Masahiko, INOUE Mitsuteru, ARAI Ken-ichi, HAYASE Toshiyuki, TAKAGI Toshiyuki

1998　(13)　67-72　1998/02/03
Prof. Dr-Ing. H. Murrenhoff Institut fur fluidtechnische Antriebe und Steuerungen RWTH Aachen, Germany

29　(1)　73-73　1998/01/15

ISSN： 1343-4608
Local Stability of Direct-Acting Poppet Valve Circuit

WANG Weimin, HAYASHI Satoru, HAYASE Toshiyuki, IIMURA Ikuro

9　(2)　35-38　1997/10/01
油圧回路に発生するカオス振動 (「スーパーコンピューティングと複雑系としての流体科学」SCFS '97)

早瀬敏幸, 林叡, 韮沢英夫

流体科学シンポジウム講演論文集　1997　28-32　1997/06
Publisher: 東北大学流体科学研究所
ISSN： 1344-2236
可変コンプライアンス特性を有する油圧サーボ系の非線形制御

早瀬敏幸, 石澤一裕, 林叡

油空圧講演論文集　9　(1)　121-124　1997/05
Advanced Oil- and Water Hydraulic Control Technologies

早瀬敏幸

M&E　23　(10)　198-205　1996/10
Transient Characteristics of Hydraulic Control Elements

早瀬敏幸, 林叡

ターボ機械　24　(9)　540-546　1996/09
Publisher: Turbomachinery Society of Japan
DOI： 10.11458/tsj1973.24.540 　

ISSN： 0385-8839
スターリングレジスタによるコロトコフ音の模擬

林叡, 是常彰人, 早瀬敏幸

油空圧講演論文集　8　(1)　129-132　1996/05
State of the Art of Oil- and Water Hydraulic Control Technologies

早瀬敏幸

計測と制御　35　(2)　106-110　1996/03

DOI： 10.11499/sicejl1962.35.106 　
平成７年度春季油空圧講演会における油圧に関する研究動向

早瀬敏幸

HPIC Quarterly, JHPS　3　7-10　1995/12
リリーフ弁の安定性 (第2報, 数値シミュレーションと実験的検討)

林叡, 飯塚祐二, 早瀬敏幸

油空圧講演論文集　7　(2)　121-124　1995/11
非線形制御による油圧サーボ系の微小スティックスリップ振動の抑制

早瀬敏幸, 林叡, 小嶋和法

油空圧講演論文集　7　(2)　125-128　1995/11
有限体積法(SIMPLER法)

早瀬敏幸

油圧と空気圧　26　407-413　1995/07
Numerical Analysis of Transient Flow through a Pipe Orifice : Time Constant for Settling Flow

HAYASE Toshiyuki, CHENG Ping, HAYASHI Satoru

JSME international journal. Ser. B, Fluids and thermal engineering　38　(2)　157-163　1995/05/15
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1340-8054

More details Close

As a fundamental consideration in hydraulic valve dynamics, transient flow through a pipe orifice has been studied via a numerical analysis. Steady axisymmetric viscous fluid flow was first investigated to confirm the present SIMPLER-based finite volume methodology. Time-dependent calculation for a suddenly imposed pressure gradient has shown two distinct characteristic time constants for the transient state. The first characteristic time is commonly considered to correspond to the flow rate change, while the second one concerning the variation of flow structure has not been treated in earlier studies. The final settling of flow is completed in the second characteristic time which is almost ten times larger than the first one under the present condition.
東北大学流体科学研究所

早瀬敏幸

計測と制御 = Journal of the Society of Instrument and Control Engineers　33　(9)　798-799　1994/09/10

ISSN： 0453-4662
第3回流体の制御,計測と可視化に関する国際シンポジウム(FLUCOME′91)報告

林叡, 早瀬敏幸, 飯村〓郎

油圧と空気圧　22　(7)　p787-791　1991/11
Publisher: 日本油空圧学会
ISSN： 0286-6900

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Books and Other Publications 6

Wearable Biosensing in Medicine and Healthcare

Toshiyuki Hayase

2024/01

DOI： 10.1007/978-981-99-8122-9 　

ISBN: 9789819981212
日常人間ドック: 2040年からのヘルスケアメッセージ

早瀬敏幸

パレード　2023/06

ISBN: 4434316370
スマートヘルスケア

早瀬敏幸

エヌ･ティー･エス　2023/01

ISBN: 9784860438128
フルードインフォマティクス

早瀬敏幸, 渡邉崇, 中村育雄, 藤代一成, 白山晋, 大林茂

技報堂出版　2010/04/30
JSME Mechanical Engineers' Handbook

青木俊之, 東恒雄,ほか

日本機械学会　2006/01/20
水圧駆動テキストブック

池尾茂, 上達政夫, ほか

日本フルードパワーシステム学会　2003/04

Show all Show first 5

Presentations 249

流体解析における計測とシミュレーションの融合とその応用 Invited

早瀬敏幸

日本機械学会2021年度年次大会　2021/09/08
計測融合シミュレーションによる血流解析 Invited

早瀬敏幸

日本機械学会第33回バイオエンジニアリング講演会　2021/06/26
Ultrasonic-measurement-integrated flow analysis for elucidation of FBG vital sign sensing International-presentation Invited

Toshiyuki Hayase

International Symposium of Wearable Systems for the Healthcare Clothing Environment 2019　2019/03/01
心臓・大動脈系の磁気共鳴画像計測融合シミュレーション Invited

早瀬敏幸

流れの数値解析と実験計測の双方向連携に関する研究分科会　2018/12/13
シミュレーション融合流体計測技術の医療分野への応用 Invited

早瀬敏幸

流れの知的制御とそれを実現するための先進計測法に関する研究分科会　2018/01/19
Measurement-Integrated Simulations in Fluid Science International-presentation

16th International Symposium on Advanced Fluid Information AFI-2016　2016/10/13
Finite element analysis for flows in a tumor microenvironment considering a leakage to interstitium:Applications to two-dimensional problems

TAKEDA Tomofumi, MIYAUCHI Suguru, HAYASE Toshiyuki

The Proceedings of the JSME Conference on Frontiers in Bioengineering　2019/07/20
Numerical Analysis of the Blood Outflow Velocity Distribution of a Left Ventricle

KOSAKA Shuta, MIYAUCHI Suguru, HAYASE Toshiyuki

The Proceedings of the JSME Conference on Frontiers in Bioengineering　2019/07/20
Numerical Analysis of the Influence of Aortic Stenosis on Blood Flow Field in the Left Ventricle:(Influence of Ejection Fraction)

TSUYOSHI Tsuyoshi, MIYAUCHI Suguru, HAYASE Toshiyuki

The Proceedings of the JSME Conference on Frontiers in Bioengineering　2019/07/20
Two-dimensional-ultrasonic-measurement-integrated blood flow analysis for the arm artery:(Blood flow in radial artery)

KIMURA Seiichi, MIYAUCHI Suguru, HAYASE Toshiyuki

The Proceedings of the JSME Conference on Frontiers in Bioengineering　2019/07/20
Fundamental Study of MR-Measurement-Integrated Simulation of Heart-Aorta-System:Bloodflow of Ascending Aorta．

HORI Yuki, MIYAUCHI Suguru, HAYASE Toshiyuki, Lalande Alain, Christophe Jean-Joseph

The Proceedings of the JSME Conference on Frontiers in Bioengineering　2019/07/20
Fluid Mechanical Effects of Near Wall Blood Flow Field on Endothelial Cell Damage:Comparison of Peeling Rate of HUVEC and HAEC in Oblique Flow Load Experiment

INOUE Kosuke, HAYASE Toshiyuki, MIYAUCHI Suguru

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2019
血管壁近傍血流場が内皮細胞損傷に与える流体力学的影響の解明（斜流負荷実験におけるHUVECとHAECのはく離率の比較）

井上浩介, 早瀬敏幸, 宮内優

日本機械学会第31回バイオエンジニアリング講演会　2018/12/15
3次元超音波計測融合血流解析システムの基礎的研究（血管形状の抽出）

工藤弘瀬, 宮内優, 早瀬敏幸, 井上浩介

日本機械学会第31回バイオエンジニアリング講演会　2018/12/15
間質領域への漏出を考慮した腫瘍微小環境の流れに対する有限要素解析（提案手法の妥当性の評価）

武田智文, 宮内優, 早瀬敏幸

日本機械学会第31回バイオエンジニアリング講演会　2018/12/15
心臓病変が左心室内の血流場に与える影響に関する数値解析（大動脈弁狭窄症）

高田剛志, 宮内優, 早瀬敏幸

日本機械学会第31回バイオエンジニアリング講演会　2018/12/15
手首拍動流モデルを用いた脈波計測システムの基礎的評価（計測信号と血管内圧、変形の解析）

坪井達哉, 白井敦, 宮内優, 早瀬敏幸

日本機械学会第29回バイオフロンティア講演会　2018/10/24
左心室の内部構造が血流場に与える影響に関する数値解析（肉柱・乳頭筋とひねり運動を考慮した解析）

細井鴻一, 宮内優, 早瀬敏幸

日本機械学会第29回バイオフロンティア講演会　2018/10/24
脳動脈瘤の肥厚部位と菲薄部位を特定する血行力学パラメータに関する研究（輸送方程式の解析に基づく肥厚部位を特定するパラメータの評価）

青木一将, 宮内優, 早瀬敏幸, 杉山慎一郎, 冨永悌二

日本機械学会第29回バイオフロンティア講演会　2018/10/24
心臓・大動脈系の磁気共鳴画像計測融合血流シミュレーションに関する基礎的研究（上行大動脈の解析）

堀雄貴, 宮内優, 早瀬敏幸, 井上浩介, Alain Lalande, Clement Acquitter, Jean-Joseph Christophe

日本機械学会第29回バイオフロンティア講演会　2018/10/24
心臓大動脈系の磁気共鳴画像計測融合血流シミュレーション

荻津正人, 堀雄貴, 宮内優, 早瀬敏幸, Cl?ment Acquitter, Alain Lalande, Christophe Jean-Joseph

統計数理研究所・東北大学流体科学研究所・材料科学高等研究所合同ワークショップ　2018/04/16
超音波計測融合シミュレーションによるFBGバイタルセンシング機序の解明（超音波ファントムによる計測実験）

原田大輔, 宮内優, 早瀬敏幸, 井上浩介, 白井敦, 児山祥平, 石澤広明

日本機械学会東北支部第53期総会・講演会　2018/03/15
Study of Hemodynamic Parameters to Identify Thickening and Thinning Parts of Cerebral Aneurysm Wall:Evaluation of the Parameters based on Analysis of Transport Equation

AOKI Kazumasa, MIYAUCHI Suguru, HAYASE Toshiyuki, SUGIYAMA Shin-ichiro, TOMINAGA Teiji

The Proceedings of the JSME Conference on Frontiers in Bioengineering　2018
Fundamental evaluation of a pulse wave measurement system using a wrist pulsatile flow model:Analysis of measured signal, blood pressure and vessel deformation

TSUBOI Tatsuya, SHIRAI Atsushi, MIYAUCHI Suguru, HAYASE Toshiyuki

The Proceedings of the JSME Conference on Frontiers in Bioengineering　2018
182 Elucidation of Mechanisms of FBG vital sensing by Ultrasonic-Measurement-Integrated simulation::Experiment using Ultrasound Flow Phantom

HARADA Daisuke, MIYAUCHI Suguru, HAYASE Toshiyuki, INOUE Kosuke, SHIRAI Atsushi, KOYAMA Shouhei, ISHIZAWA Hiroaki

The Proceedings of Conference of Tohoku Branch　2018
Two-dimensional fluid analysis for flows in a simple-shaped tumor capillary model considering a leakage to interstitium

MIYAUCHI Suguru, HAYASE Toshiyuki

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2018
Measurement of blood flow rates under three different temperatures, and development of a new human thermal model International-presentation

The 5th International Conference on Human-Environment System　2016/10/29
Analysis of an Autonomic Nervous System of Mouse Fetus with Congenital Heart Defect International-presentation

16th International Symposium on Advanced Fluid Information AFI-2016　2016/10/13
Computational and Experimental Studies on the Blood Cells Behavior in Microcirculation International-presentation

16th International Symposium on Advanced Fluid Information AFI-2016　2016/10/13
Direct Numerical Simulation of Momentum and Mass Transfer in a Spatially Developing Mixing Layer International-presentation

13th International Conference on Flow Dynamics (ICFD2016)　2016/10/13
Investigation of Non-Equilibrium Turbulence and Its Application to Flow Control (Cases of Mixing Layer, Grid-Turbulence and Jet) International-presentation

16th International Symposium on Advanced Fluid Information AFI-2016　2016/10/13
拍動に伴う血管の変形を考慮した2次元超音波計測融合血流解析システム

日本超音波医学会第89回学術集会　2016/05/28
２次元超音波計測融合血流解析システムの検証実験

融合ワークショップ　2016/03/31
ハイブリッド風洞システムによる乱流場の再現

融合ワークショップ　2016/03/31
MR画像データに基づく左心室内血流場の数値解析（心室内部表面構造の影響）

日本機械学会東北支部第51期総会・講演会　2016/03/11
ハイブリッド風洞による角柱後流乱流場の再現

日本機械学会東北支部第51期総会・講演会　2016/03/11
血管壁近傍血流場が内皮細胞損傷に与える流体力学的影響の解明(せん断応力が培養内皮細胞の剥離に及ぼす影響）

日本機械学会東北支部第51期総会・講演会　2016/03/11
生体内外血流の０次元シミュレーション（内出血と外出血の比較）

日本機械学会東北支部第51期総会・講演会　2016/03/11
拍動に伴う血管形状の変形を考慮した2次元超音波計測融合血流解析（Bモード画像による非定常血管形状抽出）

日本機械学会東北支部第51期総会・講演会　2016/03/11
2次元超音波計測融合血流解析における速度ベクトルの解析精度の検証

日本機械学会第28回バイオエンジニアリング講演会　2016/01/10
酸素濃度制御マイクロ流体デバイスによる血管内皮細胞単層の物質透過性の変化

日本機械学会第28回バイオエンジニアリング講演会　2016/01/10
生体内外血流の０次元シミュレーション

日本機械学会第28回バイオエンジニアリング講演会　2016/01/10
Measurement-Integrated Simulation of Turbulent Flow Behind a Square Cylinder International-presentation

International Workshop on Flow Dynamics and Spintronics, KTH, Stockholm　2015/11/12
Study of Permeability Changes of Endothelial Cell Monolayer Exposed to Hypoxia International-presentation

12th International Conference on Flow Dynamics (ICFD2015)　2015/10/29
Cardiac Evaluation of Fetal Mice by ECG and Ultrasound International-presentation

15th International Symposium on Advanced Fluid Information, AFI-2015　2015/10/28
Investigation of Non-equilibrium Turbulence and Its Application to Flow Control International-presentation

15th International Symposium on Advanced Fluid Information, AFI-2015　2015/10/28
Investigation on Advanced Medical Ultrasound Imaging Technology International-presentation

15th International Symposium on Advanced Fluid Information, AFI-2015　2015/10/28
Measurement-Integrated Analysis Methodology for Complex Flow Systems:Collaborative Research Overview International-presentation

15th International Symposium on Advanced Fluid Information, AFI-2015　2015/10/28
Study on Optimization of Tailing Edge for Low Noise Airfoil International-presentation

15th International Symposium on Advanced Fluid Information, AFI-2015　2015/10/28
Measurement-Integrated Analysis for Complex Flow Systems International-presentation

China-Japan Joint Workshop on Flow Dynamics and Transport Phenomena, Tsinghua University　2015/06/23
2次元超音波計測融合血流解析システムにおける最適フィードバックゲインの決定

日本超音波医学会第88回学術集会　2015/05/22
2次元超音波計測融合血流解析システムにおける超音波計測ノイズと解析精度に関する実験的検討

流体科学研究所・統計数理研究所合同ワークショップ　2015/03/26
2次元超音波計測融合血流解析システムの有用性の検証

流体科学研究所・統計数理研究所合同ワークショップ　2015/03/26
MR画像データに基づく左心室内血流場の数値解析（非定常3D心室モデルの構築）

日本機械学会東北支部第50期総会・講演会　2015/03/13
Analysis of High Reynolds Number Flow Behind a Square Cylinder by Hybrid Wind Tunnel: Reproduction of Turbulent VelocityFluctuations International-presentation

2015 Annual ELyT Workshop　2015/02/19
脳動脈瘤内の血流の数値解析における上流端の設定法の検討

日本機械学会第27回バイオエンジニアリング講演会　2015/01/10
2次元超音波計測融合シミュレーションシステムにおける解析精度の実験的検証

日本機械学会第27回バイオエンジニアリング講演会　2015/01/09
3次元非定常の超音波計測融合血流解析における圧力場の再現に関する検討

日本機械学会第27回バイオエンジニアリング講演会　2015/01/09
希釈した血液を模擬した媒質における超音波の散乱特性に関する数値解析(超音波の周波数の影響）

日本機械学会第27回バイオエンジニアリング講演会　2015/01/09
傾斜遠心顕微鏡による内皮細胞上の赤血球の摩擦特性の計測（傾斜遠心力の垂直成分の影響）

日本機械学会第27回バイオエンジニアリング講演会　2015/01/09
傾斜遠心力場における赤血球と内皮細胞との力学的相互作用の解明（相互作用モデルの物理的解釈）

日本機械学会第27回バイオエンジニアリング講演会　2015/01/09
超音波計測と計測融合シミュレーションによる血圧場と血流場の同時解析システム

日本機械学会第27回バイオエンジニアリング講演会　2015/01/09
低酸素マイクロ流体デバイスを用いた血管内皮細胞単層の物質透過性の評価

日本機械学会第27回バイオエンジニアリング講演会　2015/01/09
2次元超音波計測融合血流解析システムによる頸動脈内の血流解析

第14回日本流体力学会中四国・九州支部講演会　2014/12/14
2次元超音波計測融合シミュレーションによる頸動脈分岐部の血流解析

計測自動制御学会東北支部50周年記念学術講演会　2014/12/11
On the Motility and Locomotive Organs of Beach Flea International-presentation

The Sixth International Symposium on Aero Aqua Bio-Mechanisms (ISABME2014)　2014/11
Analysis of High Reynolds Number Flow behind a Square Cylinder by Hybrid Wind Tunnel (Improvement of Critical Gain of Instability for Pressure Feedback) International-presentation

Eleventh International Conference on Flow Dynamics (ICFD2014)　2014/10/10
Application of MR-Measurement-Integrated Hemodynamic Simulation to Cerebrovascular Diseases International-presentation

The 14th International Symposium on Advanced Fluid Information (AFI-2014)　2014/10/09
Cardiac Evaluation of Fetal Mice by ECG and Ultrasound International-presentation

The 14th International Symposium on Advanced Fluid Information (AFI-2014)　2014/10/09
Elucidation of Mechanisms of the Frictional Characteristics of Erythrocytes under Inclined Centrifugal Force International-presentation

The 14th International Symposium on Advanced Fluid Information (AFI-2014)　2014/10/09
Investigation on Advanced Medical Ultrasound Imaging Technology International-presentation

The 14th International Symposium on Advanced Fluid Information (AFI-2014)　2014/10/09
Fundamental Study of Interaction between Erythrocyte and Endothelial Cell under Inclined Centrifugal Force (Reproduction of Friction Characteristics by Numerical Analysis Using Simple Interaction Model) International-presentation

Eleventh International Conference on Flow Dynamics (ICFD2014)　2014/10/08
光電容積脈波計測と超音波計測融合シミュレーションによる頸動脈内の血圧と血流場の同時解析

日本流体力学会年会2014　2014/09/17
超音波計測融合シミュレーションにおける血流量推定手法の有効性の検証

日本流体力学会年会2014　2014/09/17
固体平板と水面でのトビムシの跳躍挙動における比較

日本流体力学会年会2014　2014/09
Simultaneous Analysis System for Blood Pressure and Flow Using Ultrasonic-Measurement-Integrated Simulation International-presentation

7th World Congress of Biomechanics　2014/07/11
Twinkling Sign機序解明のための超音波照射による微粒子挙動の光学観察

日本超音波医学会第87回学術集会　2014/05/10
ソノサイトメトリーの基盤技術の検討

日本超音波医学会第87回学術集会　2014/05/09
光電脈波計測と超音波計測融合解析による血圧血流同時計測システムによるWI解析

日本超音波医学会第87回学術集会　2014/05/09
超音波計測融合シミュレーションにおける血流量推定精度の向上

日本超音波医学会第87回学術集会　2014/05/09
ハイブリッド風洞による角柱後流の高レイノルズ数流れ解析（圧力フィードバックにおける不安定化臨界ゲインの改善）

日本機械学会東北支部第49期総会・講演会　2014/03/14
傾斜遠心力場における赤血球と内皮細胞との力学的相互作用の解明（赤血球とグリコカリックスの相互作用モデルを用いた数値解析による摩擦特性の再現）

日本機械学会東北支部第49期総会・講演会　2014/03/14
光電脈波計測と超音波計測融合シミュレーションによる血圧と血流の同時計測システムの開発（開発システムによるWave Intensityの評価）

日本機械学会第26回バイオエンジニアリング講演会　2014/01/12
小動物用超音波計測連成解析システムによる３次元血管形状抽出と血流解析の精度検証

日本機械学会第26回バイオエンジニアリング講演会　2014/01/12
総頸動脈内血流の2次元超音波計測融合シミュレーションにおける2次元断面流量の軸方向変化の影響

日本機械学会第26回バイオエンジニアリング講演会　2014/01/12
超音波計測融合シミュレーションにおける血流量推定の評価関数に関する考察

日本機械学会第26回バイオエンジニアリング講演会　2014/01/12
脳動脈瘤の壁面性状と血行力学パラメータの比較

日本機械学会第26回バイオエンジニアリング講演会　2014/01/11
Characteristics of Turbulent/Non-Turbulent Interface in a Turbulent Planar Jet with a Chemical Reaction International-presentation

American Physical Society 66th Annual Meeting of the APS Division of Fluid Dynamics　2013/11
Scalar Transfer Across a Turbulent/Non-Turbulent Interface in a Planar Jet International-presentation

American Physical Society 66th Annual Meeting of the APS Division of Fluid Dynamics　2013/11
DNSによる二次元噴流中の反応性物質の乱流拡散係数に関する研究

日本流体力学会年会2013　2013/09
乱流生成方法により格子乱流の基本特性を変える試み

日本流体力学会年会2013　2013/09
DNSによる化学反応を伴う二次元噴流の可視化

第41回可視化情報シンポジウム　2013/07
超音波Mモードイメージングと光電容積脈波センシングによる脈波同定の比較

曾根周作, 早瀬敏幸, 船本健一

超音波医学　2013/04
超音波計測融合シミュレーションによる生体内の血液粘度の推定

門脇弘子, 船本健一, 早瀬敏幸, 曾根周作, 地挽隆夫, 橋本浩, 見山広二, 劉磊

超音波医学　2013/04
小動物用超音波計測連成解析システムにおける血管形状抽出の高精度化

日本機械学会第23回バイオフロンティア講演会　2012/10/06
2次元超音波計測融合シミュレーションによる頸動脈分岐部の血流解析

日本機械学会第23回バイオフロンティア講演会　2012/10/05
超音波計測融合血流シミュレーションシステムの開発

第21回日本形成外科学会基礎学術集会　2012/10/05
Integration of CFD and EFD for Analysis of Complex Real Flows International-presentation

5th Symposium on Integrating CFD and Experiments in Aerodynamics (Integration 2012)　2012/10/04
Rheological Analysis of the Mechanism of Fetal Brain Hemorrhage International-presentation

The 12th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2012)　2012/09/20
Ultrasound Radiation Force Driven B-Flow Twinkling Sign for Microcalcification Detection International-presentation

The 12th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2012)　2012/09/20
Magnetic Resonance Fluid Dynamics for Intracranial Aneurysms International-presentation

The 12th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2012)　2012/09/20
Numerical Analysis of Levitation Mechanism of Red Blood Cell in Inclined Centrifuge Microscope - Effect of Asymmetric Cell Shape on the Motion International-presentation

9th International Conference on Flow Dynamics (ICFD2012)　2012/09/20
Intra-left Atrial Flow International-presentation

The 9th International Conference on Flow Dynamics (ICFD2012)　2012/09/19
実験計測と数値解析の融合流体解析

日本機械学会2012年度年次大会　2012/09/10
Neumerical and Experimental Study of Flow in Stenosis models with Several Mechanical Properties International-presentation

Ninth International Conference on Flow Dynamics　2012/09
視覚協創学(9)：視覚協創による血流動態のリアライゼーション

計算工学講演会　2012/05/30
視覚協創学(1)：視考支援基盤の目的と構成

計算工学講演会　2012/05/30
軟組織内微細石灰化のB-Flow“Twinkling Sign”発生メカニズムに関するin vitro研究

日本超音波医学会第85回学術集会　2012/05/26
2次元超音波計測融合シミュレーションによる頸動脈分岐部の非定常血流量推定

日本超音波医学会第85回学術集会　2012/05/25
Ultrasonic-Measurement-Integrated Simulation of Blood Flows International-presentation

Bilateral Workshop on Green Technology and Life Science between Chang Gung University and Tohoku University　2012/05/15
Blood Flow Analysis in the Left Atrium with/without Atrial Fibrillation International-presentation

The 4th East Asian Pacific Student Workshop on Nano-Biomedical Engineering　2010/12/16
Some Theoretical Issues on Measurement-Integrated Simulation International-presentation

4th East Asian Pacific Student Workshop on Nano-Biomedical Engineering　2010/12/16
Experimental Validation of Ultrasonic-Measurement-Integrated Blood Flow Simulation Using Carotid Artery Models International-presentation

The 4th East Asian Pacific Student Workshop on Nano-Biomedical Engineering　2010/12/15
Observation of velocity of Antibody-modified HL60 cells on glass plates using the inclined centrifuge microscope International-presentation

4th East Asian Pacific Student Workshop on Nano-Biomedical Engineering　2010/12
MR-Measurement-Integrated Simulation for Reproduction of Blood Flow in Cerebral Aneurysm International-presentation

Swiss/Japan International Seminar on Medical Engineering Based on Vessel Biology　2010/11/15
小動物用超音波計測融合シミュレーションシステムの開発（検証実験）

第21回バイオフロンティア講演会　2010/11/13
超音波計測融合シミュレーションによる頚動脈内の壁せん断応力の評価

第21回バイオフロンティア講演会　2010/11/13
心房細動に関する左心房内血流解析

第21回バイオフロンティア講演会　2010/11/12
Computer Simulation Predicts the Convective Drug Distribution in the Primate Brainstem International-presentation

The tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2010)　2010/11/02
Consideration for Simulations of Infusion in Realistic Animal Brain Geometries International-presentation

The tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2010)　2010/11/02
Detection of Microcalcification in Soft Tissue International-presentation

The tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2010)　2010/11/02
Evaluation of Wall Shear Stress on Carotid Artery with Ultrasonic-Measurement-Integrated Simulation International-presentation

The seventh International Conference on Flow Dynamics　2010/11/02
Fluid Analysis of the Mechanism of Fetal Brain Hemorrhage International-presentation

The tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2010)　2010/11/02
Left Atrial Appendage International-presentation

The tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI-2010)　2010/11/02
Design of Version Tree Operators for Sophisticated Visualization Provenance International-presentation

Tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　2010/11
Direct Numerical Simulation on the Effects of Free-stream Turbulence on an Isothermal Turbulent Boundary Layer International-presentation

Tenth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　2010/11
Experimental Study on Effect of Direction of Endothelial Cells’ Orientation on Motion of HL60 Cells International-presentation

The 7th International Conference on Flow Dynamics　2010/11
Measurement-Integrated Simulations Applied to a Co-Flowing Jet International-presentation

Seventh International Conference on Flow Dynamics　2010/11
血管内皮細胞の配向方向が好中球の挙動に与える影響に関する実験的研究

日本機械学会第21回バイオフロンティア講演会　2010/11
医療計測との融合による血流解析

日本機械学会第88期流体工学部門講演会　2010/10/31
血流の超音波計測融合シミュレーションにおけるゼロ表示されたドプラ速度のフィードバックの影響

日本流体力学会年会2010　2010/09/10
傾斜遠心顕微鏡で撮影された連続画像のぶれ補正手法

日本流体力学会年会2010　2010/09
傾斜遠心顕微鏡を用いたガラス平板上におけるHL60の微視的挙動に関する基礎的研究

日本機械学会2010年度年次大会　2010/09
Computational Simulation on Convection-Enhanced Drug Delivery into the Primate Brain International-presentation

The 6th World Congress of Biomechanics　2010/08/04
Effect of Measurement Error on Ultrasonic-Measurement-Integrated Simulation of Blood Flow in an Aortic Aneurysm International-presentation

The 13th International Symposium of 2007 Tohoku University Global COE Program “Global Nano-Biomedical Engineering Education and Research Network Centre”　2010/08/04
A Stabilization Technique of Wobbly Images taken by the Inclined Centrifuge Microscope International-presentation

6th World Congress of Biomechanics　2010/08
Visualization of Microcirculation Based on Brightness Variation in Contrast-Enhanced Ultrasound International-presentation

ASME 2010 Summer Bioengineering Conference　2010/06/17
Measurement-Integrated Simulations and Kalman Filter Applied to a Co-Flowing Jet International-presentation

AIAA 5th Flow Control Conference　2010/06
計測融合シミュレーションの臨界ゲインについての考察

流体力学講演会　2010/06
超音波計測融合シミュレーションによる臨床応用に関する基礎的研究

日本超音波医学会第83回学術集会　2010/05/30
超音波計測融合シミュレーションによる分岐血管の流量推定

日本超音波医学会第83回学術集会　2010/05/29
傾斜遠心力下における赤血球挙動の流体構造連成解析

第15回計算工学講演会　2010/05/26
大動脈瘤内における非定常血流に関する情報探査

第15回計算工学講演会　2010/05/26
2次元下行大動脈瘤近傍における血流の計測融合シミュレーションに関する固有値解析

日本機械学会東北支部第45期総会・講演会　2010/03/12
Determination of Local Fine Structure of Blood Flows by Measurement Coupled Simulation International-presentation

12th International Symposium of Tohoku University Global COE Programme Global Nano-Biomedical Engineering Education and Research Network Centre　2010/03
Eigenvalue Analysis for Error Dynamics of Measurement-Integrated Simulation of Blood Flow International-presentation

12th International Symposium of Tohoku University Global COE Programme Global Nano-Biomedical Engineering Education and Research Network Centre　2010/03
Clinical Application of Ultrasonic-Measurement-Integrated Simulation for Diagnosis of Carotid Artery International-presentation

SMART-Tohoku GCOE joint Workshop on Micro & Nano Bioengineering: MIT, NUS, NTU and Tohoku　2010/01/12
集中定数モデルによる循環器系病態の動特性解析第2報：心室中隔欠損症の考察

第22回バイオエンジニアリング講演会　2010/01/10
超音波Bモード画像の輝度値の変動に基づく微小循環の可視化

第22回バイオエンジニアリング講演会　2010/01/10
PVA頚動脈モデルを用いた3次元超音波計測融合血流シミュレーション

第22回バイオエンジニアリング講演会　2010/01/09
曲がり管の運動が流れに与える影響に関する数値解析

日本機械学会第22回バイオエンジニアリング講演会　2010/01
Analysis of Clinical Data with Ultrasonic-Measurement-Integrated Simulation International-presentation

The 3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering　2009/12
Dynamic Characteristics Analysis of Diseased Circulatory System with Lumped Parameter Model 1st Report : Heart Valve Disease International-presentation

The 3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering　2009/12
Eigenvalue Analysis for Error Dynamics of Ultrasonic-Measurement-Integrated Simulation of Blood Flow in the Aneurismal Aorta International-presentation

3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering　2009/12
Experimental Observation of Behavior of Neutrophil-like HL60 Cells on Oriented Endothelial Cells International-presentation

3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering　2009/12
Three-Dimensional Ultrasonic-Measurement-Integrated Blood flow Simulation using PVA Carotid Artery Model International-presentation

The 3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering　2009/12
Turbulence Structure and Scalar Transfer in Fractal Generated Turbulence International-presentation

Japan-Korea CFD Workshop　2009/12
Eigenvalue Analysis to Design Feedback Scheme in Measurement-Integrated Simulation International-presentation

ASME International Mechanical Engineering Congress (IMECE 2009)　2009/11/19
血流の超音波計測融合シミュレーションに関する研究第9報：計測ノイズの影響

第20回バイオフロンティア講演会　2009/11/08
集中定数モデルによる循環器系病態の動特性解析第1報：心臓弁膜症の考察

第20回バイオフロンティア講演会　2009/11/08
超音波計測融合シミュレーションによる臨床データの解析

第20回バイオフロンティア講演会　2009/11/07
Atrial Vortex International-presentation

The 9th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　2009/11/05
Blood Flow Analysis by Measurement-Integrated Simulation International-presentation

The 9th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　2009/11/05
Convection-enhanced Delivery of ACNU under MRI Monitoring against Recurrent Gliomas-Development of Computational Simulation of Drug Distribution International-presentation

The 9th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　2009/11/05
Fundamental Study of Convection-Enhanced Delivery Simulation in Rat Brain International-presentation

The 9th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　2009/11/05
Realizing Scalable Visualization Through Hierarchical Provenance Management International-presentation

The Ninth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　2009/11/05
Direct Numerical Simulation on the Effects of Free-stream Turbulance on Neutral, Stably and Unstably Stratified Turbulance Boundary Layers International-presentation

Ninth International Symposium on Advanced Fluid Information and The Fourth International Symposium on Transdisciplinary Fluid Integration　2009/11
生体モデリングにおける音響特性の制御と超音波計測

計測自動制御学会東北支部45周年記念学術講演会　2009/09/08
健康度のわかる血管情報の可視化

第8回情報科学技術フォーラム　2009/09/04
Measurements-integrated simulations applied to the case of a planar coflowing jet: results and experimental validation International-presentation

4th Symposium on integrating CFD and experiments in aerodynamics　2009/09
計測融合シミュレーションの誤差ダイナミクスに対する固有値解析

計測自動制御学会東北支部45周年記念学術講演会　2009/09
血管内皮細胞の配向が好中球の挙動に与える影響に関する実験的研究

日本機械学会2009年度年次大会　2009/09
Direct Numerical Simulation of Scalar Transfer in Regular and Fractal Grid Turbulence International-presentation

International Conference ”Turbulent Mixing and Beyond”　2009/08
フラクタル格子乱流の特性とスカラー輸送について

数理科学講演会　2009/08
複雑な実現象流れ場の計測融合リアルタイムシミュレーション

平成21年春季フルードパワーシステム講演会　2009/06/25
Reproduction of Blood Flow Field by Numerical Simulation Integrated with Ultrasonic Measurement with Noise International-presentation

ASME 2009 Summer Bioengineering Conference　2009/06/18
DNS of Passive Scalar Field with Mean Gradient in Fractal-Generated Turbulence International-presentation

Sixth International Symposium on Turbulence and Shear Flow Phenomena　2009/06
計測融合シミュレーションの誤差ダイナミクスに対する固有値解析

第41回流体力学講演会／航空宇宙数値シミュレーション技術シンポジウム2009　2009/06
超音波計測融合シミュレーションによる血行力学情報のリアルタイム可視化に関する研究

日本超音波医学会第82回学術集会　2009/05/24
Effect of Aliasing on Ultrasonic-Measurement-Integrated Simulation of Three-Dimensional Unsteady Blood Flow International-presentation

The 10th International Symposium of 2007 Tohoku University Global COE Program “Global Nano-Biomedical Engineering Education and Research Network Centre”　2009/04/17
Study on the Development of Blood Vessel Biomodeling with Realistic Mechanical Properties by Using Poly (vinyl alcohol) Hydrogel International-presentation

4th Asian Pacific Conference on Biomechanics　2009/04/17
Formulation for Eigenvalue Analysis of Error Dynamics of Measurement-Integrated Simulation International-presentation

4th Asian Pacific Conference on Biomechanics　2009/04
Blood Flow Analysis by Ultrasonic-Measurement-Integrated Simulation with Flow Rate Estimation International-presentation

9th International Symposium of Tohoku University Global COE Programme Global Nano-Biomedical Engineering Education and Research Network Centre　2009/03
Determination of Local Fine Structure of Blood Flows by Measurement Coupled Simulation International-presentation

9th International Symposium of Tohoku University Global COE Programme Global Nano-Biomedical Engineering Education and Research Network Centre　2009/03
Eigenvalue Analysis for Error Dynamics of Measurement-Integrated Simulation International-presentation

9th International Symposium of Tohoku University Global COE Programme Global Nano-Biomedical Engineering Education and Research Network Centre　2009/03
Fluid-Structure Coupled Ultrasonic-Measurement-Integrated Simulation of Fluid in Elastic Tube with Contraction International-presentation

9th International Symposium of Tohoku University Global COE Programme Global Nano-Biomedical Engineering Education and Research Network Centre　2009/03
Reproduction of Complex Real Flows by Measurement-Integrated Simulation International-presentation

International Symposium of Experiment-Integrated Computational Chemistry on Multiscale Fluidics (ECCMF)　2009/01/18
傾斜遠心顕微鏡を用いた好中球の内皮細胞に対する摩擦特性の計測

日本機械学会第21回バイオエンジニアリング講演会　2009/01
血流の超音波計測融合シミュレーションに関する研究第8報：計測誤差の影響

第21回バイオエンジニアリング講演会　2009/01
生体に近い音響特性を有するPVAゲルの開発

第21回バイオエンジニアリング講演会　2009/01
拍動流に起因する曲がり管の動きが流れに与える影響

日本機械学会第21回バイオエンジニアリング講演会　2009/01
脈診の科学的検証のための一次元数学モデルを用いた脈波計測実験の再現

日本機械学会第21回バイオエンジニアリング講演会　2009/01
流れ負荷および遠心力負荷によるせん断応力の垂直方向分布の差が培養内皮細胞の配向に与える影響

日本機械学会第21回バイオエンジニアリング講演会　2009/01
Anisotropic Hybrid Blood Vessel Model using Poly (Vinyl Alcohol) Hydro Gel and Mesh Material International-presentation

GPBE/NUS-Tohoku Graduate Student Conference in Bioengineering　2008/12
Development of Poly (Vinyl Alchol) Gel with in vivo Acoustic Properties International-presentation

GPBE/NUS-Tohoku Graduate Student Conference in Bioengineering　2008/12
Effect of Vertical Distribution of Shear Stress Generated by Flow or Centrifugal Force on Orientation of Cultured Endothelial Cell International-presentation

GPBE/NUS-Tohoku Graduate Student Conference in Bioengineering　2008/12
Formulation of Linearized Error Dynamics Equation of Measurement-Integrated Simulation International-presentation

GPBE/NUS-Tohoku Graduate Student Conference in Bioengineering　2008/12
Measurement of Friction Characteristics of Neutrophils on MPC Polymer with the Inclined Centrifuge Microscope International-presentation

GPBE/NUS-Tohoku Graduate Student Conference in Bioengineering　2008/12
Numerical Evaluation of MR-Measurement-Integrated Simulation of Unsteady Hemodynamics in a Cerebral Aneurysm International-presentation

The 8th International Symposium of 2007 Tohoku University Global COE Program “Global Nano-Biomedical Engineering Education and Research Network Centre”　2008/12
Physics Data Mining for Three-Dimensional Unsteady Blood Flow Field in an Aneurysmal Aorta International-presentation

The 8th International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　2008/12
Reproduction of Pulse Waveform Measurement using One-dimensional Mathematical Model for Validation of Pulse Diagnosis International-presentation

GPBE/NUS-Tohoku Graduate Student Conference in Bioengineering　2008/12
Reproduction of Three-Dimensional Flow with Karman Vortex Street by Integrating Flow Simulation and Pressure Measurement International-presentation

Eighth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration　2008/12
Reproduction of Complex Real Flows with Measurement-Integrated Simulation International-presentation

ASME International Mechanical Engineering Congress and Exposition　2008/11/04
Eigenvalue Analysis for Error Dynamics of Measurement Integrated Simulation to Reproduce Real Flows International-presentation

61st Annual Meeting of the APS Division of Fluid Dynamics　2008/11
Measurement-Integrated Simulation of Three-Dimensional Flow Behind a Square Cylinder Using Pressure Measurement on the Cylinder International-presentation

61st Annual Meeting of the APS Division of Fluid Dynamics　2008/11
Reproduction of Complex Real Flows by Integrating Measurement and Simulation International-presentation

Tsinghua University and IFS, Tohoku University Joint Workshop　2008/10/27
Estimation of Unsteady Blood Flow Rate in Ultrasonic-Measurement-Integrated Simulation －Effect of Estimation Precision on Reproducibility of Blood Flow International-presentation

International Symposium on Nano-Biomedical Engineering, 7th International Symposium of 2007 Tohoku University Global COE Program “Global Nano-Biomedical Engineering Education and Research Network Centre　2008/10
MR計測融合シミュレーションによる脳動脈瘤内の非定常流再現の数値実験

第19回バイオフロンティア講演会　2008/09
PVAハイドロゲルとメッシュ材料を用いた異方性血管モデルの製作

日本機械学会第19回バイオフロンティア講演会　2008/09
傾斜遠心顕微鏡を用いた好中球のMPCポリマーに対する摩擦特性の計測

日本機械学会第19回バイオフロンティア講演会　2008/09
生体の音響特性を有する材料の開発：音響特性計測装置の構築

第19回バイオフロンティア講演会　2008/09
生体計測とシミュレーションの一体化

第１回東北大学バイオフォーラム　2008/06/06
GADGET/FV: Ontology-supported design of visualization workflows in fluid science International-presentation

The first International Workshop on Super Visualization 2008　2008/06
Numerical Experiment of MR-Measurement-Integrated Simulation of Steady Blood Flow in a Cerebral Aneurysm International-presentation

ASME 2008 Summer Bioengineering Conference　2008/06
PIV計測融合シミュレーションにおけるフィードバックデータ率の影響

第40回流体力学講演会／航空宇宙数値シミュレーション技術シンポジウム2008　2008/06
Development of Material Close to Anatomy: Experimental Apparatus to Measure Acoustic Properties International-presentation

Tohoku-NUS Student Joint Symposium　2008/05
MR計測融合シミュレーションによる脳動脈瘤内の定常流再現の数値実験

第13回計算工学講演会　2008/05
PVA-Hによる超音波計測・可視化同時実験用頚動脈ファントム

日本超音波医学会第81回学術集会　2008/05
超音波計測融合シミュレーションによる血流場の可視化

日本超音波医学会第81回学術集会　2008/05
Determination of Fine Structure of Blood Flows by Coupling Measurement and Simulation International-presentation

5th International Symposium on Tohoku University Global COE Program Global Nano-Biomedical Engineering Education and research Network Centre　2008/03/28
Accuracy Verification of Ultrasonic Measurement for Ultrasonic-Measurement-Integrated Simulation Using Poly (vinyl alcohol) Hydrogel Straight Tube Phantom International-presentation

5th International Symposium on Global COE Program Global Nano-Biomedical Engineering Education and Research Network Centre　2008/03
Numerical Evaluation of Ultrasonic-Measurement-Integrated Simulation of Blood Flow International-presentation

The 5th International Bio-Fluid Symposium and Workshop　2008/03
計測との融合による流れの実現象のリアルタイムシミュレーション

早瀬敏幸

EFD/CFD融合研究会　2008/02/26
Examples of Collaborative Japan- U.S. Fluids Information Triad Research International-presentation

46th AIAA Aerospace Sciences Meeting and Exhibition　2008/01/09
MRI計測に基づく左心房内血流場の数値シミュレーション

日本機械学会第20回バイオエンジニアリング講演会　2008/01
MR計測融合シミュレーションによる脳動脈瘤内の血流解析

第20回バイオエンジニアリング講演会　2008/01
傾斜遠心顕微鏡による生理的温度条件下での赤血球の摩擦特性の計測

日本機械学会第20回バイオエンジニアリング講演会　2008/01
超音波計測による3次元血流動態可視化システムの開発

日本機械学会第20回バイオエンジニアリング講演会　2008/01
超音波計測融合シミュレーションにおける直円管内層流の解析（非軸対称フィードバック則による3次元解析）

第20回バイオエンジニアリング講演会　2008/01
超音波計測融合シミュレーションにおける直円管内層流の解析：軸対称フィードバック則による軸対称解析

第20回バイオエンジニアリング講演会　2008/01
平板上を移動する変形した赤血球まわりの3次元流動数値解析

第20回バイオエンジニアリング講演会　2008/01
Effects of Number of Feedback Points in PIV Measurement-Integrated Simulation International-presentation

Takayuki Yamagata, Toshiyuki Hayase, Hiroshi Higuchi

Seventh International Symposium on Advanced Fluid Information and Fourth International Symposium on Transdisciplinary Fluid Integration　2007/12/14
MR-Measurement-Integrated Simulation of Blood Flow in a Cerebral Aneurysm International-presentation

Yoshitsugu Suzuki, Kenichi Funamoto, Toshiyuki Hayase, Takashi Kosugi, Haruo Isoda

Seventh International Symposium on Advanced Fluid Information and Fourth International Symposium on Transdisciplinary Fluid Integration　2007/12/14
Development of a Three-Dimensional Blood Vessel Image Acquisition System with Ultrasonic Diagnostic Equipment International-presentation

Kosuke Takeuchi, Kosuke Inoue, Toshiyuki Hayase

Seventh International Symposium on Advanced Fluid Information and Fourth International Symposium on Transdisciplinary Fluid Integration　2007/12/14
Three-Dimensional Flow Simulation Around a Deformed Red Blood Cell Moving on a Flat Plate International-presentation

Yuki Okuyama, Toshiyuki Hayase, Kenichi Funamoto

Seventh International Symposium on Advanced Fluid Information and Fourth International Symposium on Transdisciplinary Fluid Integration　2007/12/14
Friction Characteristics of Red Blood Cells Under Physiological Temperature Condition Measured with an Inclined Centrifuge Microscope International-presentation

Tomomi Haganuma, Toshiyuki Hayase, Kosuke Inoue, Motohiro Takeda

Seventh International Symposium on Advanced Fluid Information and Fourth International Symposium on Transdisciplinary Fluid Integration　2007/12/14
Numerical Simulation of Blood Flow in Left Atrium Modeled with Magnetic Resonance Imaging International-presentation

Yusuke Kanke, Toshiyuki Hayase, Tomoyuki Yambe, Muneichi Shibata, Yasuyuki Shiraishi

Seventh International Symposium on Advanced Fluid Information and Fourth International Symposium on Transdisciplinary Fluid Integration　2007/12/14
超音波計測融合シミュレーションによる血流解析（教育講演）

早瀬敏幸

第17回日本シミュレーション外科学会　2007/10/20
Integration of Measurement and Simulation in Complex Blood Flow Researches in Super-Real-Time Medical Engineering Laboratory International-presentation

Proceedings of 3rd International Conference on Flow Dynamics　2006/11
Blood Flow Simulation Coupled with Ultrasonic Measurement International-presentation

Toshiyuki Hayase, Kenichi Funamoto

The 1st Japan Korea Student Workshop　2006/11
大動脈瘤内血流の超音波計測融合シミュレーション

EnSightフォーラム　2006/10
Ultrasonic-measurement-integrated simulation of blood flows International-presentation

3rd International Intracranial Stent Meeting　2006/09
計測融合シミュレーションによる流れ解析と医療への応用

第２回REDEEMシンポジウム医療工学の最前線　2006/08
傾斜遠心力場の血漿中でガラス板および内皮細胞上を移動する赤血球の摩擦特性

早瀬敏幸, 神取孝司, 芳賀沼智美, 井上浩介

第29回日本バイオレオロジー学会年会　2006/06
計測と計算の融合による流れの実現象のリアルタイム再現技術

JSAEシンポジウム　2006/03/08
Transdisciplinary Methodology Integrating Measurement and Simulation in Application of Complex Biomedical Flows International-presentation

Toshiyuki HAYASE, Kenichi FUNAMOTO, Takayuki YAMAGATA, Lei LIU, Atsushi SHIRAI, Makoto OHTA, Kosuke INOUE, Yoshifumi SAIJO, Tomoyuki YAMBE

Fifth International Symposium on Advanced Fluid Information (AFI-2005)　2005/12/08
血球摩擦特性の計測と数値シミュレーションの融合による毛細血管内血流の解明

第9回オーガナイズド混相流フォーラム　2005/10/17
計測とシミュレーションの融合による流れの実現象の再現

応用数理学会年会　2005/09/25
REPRODUCTION OF EXACT TURBULENT FLOW STRUCTURE USING MEASUREMENT-INTEGRATED SIMULATION International-presentation

T. Hayase, K. Imagawa

Eighth U.S. National Congress on Computational Mechanics, USNCCM8　2005/07/24

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Industrial Property Rights 4

血圧推定装置、情報処理装置、血圧推定方法、及び、血圧推定プログラム

早瀬敏幸

Property Type: Patent
血圧計用カフ

早瀬敏幸, 臼田孝史

Property Type: Patent
血流可視化診断装置

早瀬敏幸, 船本健一, 白井敦, 山家智之, 西條芳文

特許第4269623号

Property Type: Patent
単箱式接線流羽根車式計量装置

早瀬敏幸

Property Type: Patent

Research Projects 34

スマートテキスタイルの創製とヘルスケア衣環境への実用展開に関する研究

細谷聡, 早瀬敏幸, 児山祥平, 坂口明男, 藤本圭作, 石澤広明

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(S)

Institution: 信州大学

2017/05/31 - 2022/03/31
Prediction of peeling of endothelial cells by magnetic-resonance-imaging measurement-integrated blood flow simulation Competitive

Hayase Toshiyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2018/04 - 2021/03

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The mechanism of endothelial cell peeling on the surface of blood vessels, which triggers the development of vascular lesions such as arteriosclerosis and aneurysms, is still not well understood. The purpose of this study was to obtain knowledge for prediction of endothelial cell peeling by revealing the hydrodynamic action of blood flow near the surface of blood vessels that causes endothelial cell peeling. For the aorta, which is a common site of cardiovascular diseases such as aneurysms, the detailed flow field near the blood vessel wall was clarified by nuclear magnetic resonance imaging measurement fusion blood flow simulation, and the effect of the flow field near the vascular wall on the peeling of endothelial cells was clarified by the experiment, and the relationship between hemodynamic parameters and endothelial cell peeling was clarified by comparing the results.
Advanced human thermophysiological model for evaluating health risks due to thermal environments

GOTO TOMONOBU, TAKAKI RIE

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2016/04/01 - 2019/03/31

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In order to establish a new human thermophysiological model which can predict not only body temperature but also blood pressure and blood flow rate, we conducted reference data collections through some experiments and field surveys, and developments of the sub-models which compose our new model. In the experiments and field surveys, we obtained detailed physiological data under six steady-state and two unsteady-state conditions, and data on the daily life fluctuations of exposure temperature, blood pressure, etc. in winter. As the sub-model developments, we improved the thermal network and cardiovascular models, and verified their applicability. In addition, we developed a prototype of the physiological model to simulate the regulations of sweat, blood pressure and blood flow rate.
Clarification of fluid dynamical effect of near-wall flow field on enrtherial cell damage by measurement-integrated-simulation

Hayase Toshiyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2015/04/01 - 2018/03/31

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It is known that damage on endothelial cells on the surface of a blood vessel causes diseases of blood vessels such as atherosclerosis or aneurisms. However, its mechanism is unknown. This study aimed to clarify the effect of flow field on the endothelial cells’ damage. A complex flow field near the surface of a carotid artery was reconstructed in a flow chamber and experiment of cell peeling by the flow load was conducted. Ultrasonic measurement integrated simulated was also performed to clarify the complex flow field in a carotid artery. Results obtained in this study are expected to be used in developing new diagnostic method of circulatory diseases based on understanding of fluid dynamical effect on cell damages.
Development of an Integrated Environment for Forensic Visual Analytics

Fujishiro Issei, WANG Yunhai

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (A)

Institution: Keio University

2014/04/01 - 2017/03/31

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In this study, we developed an integrated environment for forensic visual analytics. First of all, we defined the forensics ontology to standardize autopsy tasks. Then, we built on the ontology to design a legal medicine mark-up language, called LMML, and implemented designated authoring tool and browser. Users are allowed to generate an individual injured body model in 3D and performed internal and external blood flow simulation and visualization. The developed environment enabled visual analytics to clarify complex mutual relationships among evidences obtained through autopsy and on-the-spot investigation.
Clarification of mechanical interaction between erythrocytes and endothelial cells in an inclined centrifugal force field

Hayase Toshiyuki, INOUE KOSUKE, MIYAUCHI SUGURU

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2014/04/01 - 2017/03/31

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Elucidation of the mechanical interaction between an erythrocyte and an endothelial cell is an important issue relating to mechanisms of cardiovascular diseases. The objective of this study was to clarify the mechanical interaction between an erythrocyte moving in medium subject to inclined centrifugal force and endothelial cells on a plate. Three-dimensional numerical simulation was performed with contact force models between an erythrocyte and glycocalyx on the surface of endothelial cells and two-dimensional analysis was conducted using a lubrication theory for compressible porous media and a simple erythrocyte model. In the 3D simulation, two contact force models were adopted in which shear stresses acting on the bottom surface of an erythrocyte varied proportional or inversely proportional to the distance to the base plate. As a result, the experimental frictional characteristics for an endothelia-cultured plate were properly reproduced by the inverse proportion model.
Prediction of the wall property and rupture risk of cerebral aneurysms based on the computational fluid dynamics

Niizuma Kuniyasu, SUGIYAMA SHIN-ICHIRO, NAKAGAWA ATSUHIRO, HAYASE TOSHIYUKI, OHTA MAKOTO, FUNAMOTO KENICHI, ARAFUNE TATSUHIKO, WASHIO TOSHIKATSU

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Young Scientists (A)

Institution: Tohoku University

2013/04/01 - 2016/03/31

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The purpose of this study was to build a large-scale cerebral aneurysm database including computational fluid dynamics (CFD) analysis, and to predict wall property and rupture risk. In the 3 years around 500 cases were included. Based on the database, we reported that the yellowish wall can be predicted by CFD. In addition, we revealed that rupture risk or recanalization after coil embolization could be predicted by CFD. Further analysis based on the database and outpatient clinic system are planned.
Spatio-temporal analysis of blood flow in bifurcation of blood vessel using ultrasonic-measurement-integrated simulation

HAYASE Toshiyuki, OBAYASHI Shigeru, SAIJO Yoshifumi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2012/04/01 - 2015/03/31

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It has been pointed out that hemodynamics has a strong relationship with occurrence and development of circulatory diseases. However primary parameter to these diseases is still unknown. This research was conducted for a simultaneous analysis of blood pressure (BP) and flow in a carotid artery using photoplethysmography (PPG) and two-dimensional ultrasonic-measurement-integrated (2D-UMI) simulation. The system analyzes BP and flow fields from the viewpoint of influence of phases of BP and flow corresponding to forward and backward waves on vessel wall. The simultaneous analysis system using PPG and 2D-UMI simulation was developed, and characteristics of the blood flow field in a carotid artery was clarified focusing on time variation of the phase corresponding to forward and backward waves identified by wave intensity (WI).
超音波計測融合血流解析システムによる動脈硬化の超早期診断法の確立

早瀬敏幸

System: 産学が連携した研究開発成果の展開研究成果展開事業研究成果最適展開支援プログラム(A-STEP) 探索タイプ

Institution: 東北大学

2013 - 2013

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2次元超音波計測融合血流解析システムにより、健常または疾患を有する任意の頚動脈の超音波カラードプラ計測データに基づく血流解析を可能にし、得られる血行力学パラメータに基づく動脈硬化の超早期診断法を確立することを目的に研究を実施した。動脈硬化が進行して狭窄や蛇行を有する血管についても血流解析を行うことが可能になり、システムの汎用性が向上した。また、本血流解析システムにより得られる血流動態や血行力学パラメータと医師による臨床所見とを比較した結果、血管の状態により内部の血流の速度変化と分布が異なることで壁せん断応力分布に差異が生じ、本システムにより動脈硬化を検出できる可能性が確認された。今後、開発した血流解析機能を実際の超音波診断装置内に搭載することにより臨床応用へと展開する。
Development of Sono-cytometry by High Frequency Ultrasound

SAIJO Yoshifumi, KANAI Hiroshi, HAYASE Toshiyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2011 - 2012

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Microfluidic circulation with suspension of micro-molecules was observed by high speed CCD camera. High frequency ultrasound of 120 MHz was emitted to the model and the spectrum of the reflected ultrasound was analyzed by neural network. The dimensions and structures of the micro-molecules were evaluated by the method. Application of the blood flow or lymph flow to the method in living subjects may realize in vivo “sono-cytometry" in the near future.
Clarification of Endothelial Cells' Response to Flow Force andInclined Centrifugal Force

HAYASE Toshiyuki, INOUE Kousuke, OSHIBE Takashi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2011 - 2012

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Mechanism of endothelial cells' response to blood flow is crucial for clarification of the mechanism of occurrence and development of circulatory diseases and development of new treatment and prevention methods. In this research we proposed a new experimental methodology to investigate the endothelial cells' response to mechanical stimulation. The cells' response to the centrifugal force was compared with those to the conventionalflow force stimulation. The experimental results provide useful information on the location of shear stress sensing in endothelial cells.
Development of a Cooperative Visualization Lifecycle ManagementMiddleware

FUJISHIRO Issei, HAYASE Toshiyuki, TAKESHIMA Yuriko, TAKAHASHI Shigeo, TAKAYAMA Tsuyoshi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Keio University

2010 - 2012

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In this research project, a novel visualization ontology is defined torealize a user support mechanism which searches the case repository for appropriatetechniques so as to meet his/her requirements and executes the corresponding workflows ina semi-automa
Development of a real time diagnosis of lymph node metastasis by ultrasound and nanobubbles

KODAMA Tetsuya, HAYASE Toshiyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2009 - 2011

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The aim of the present study is to develop a real time diagnostic method of lymphatic metastasis less than 1cm in diameter. First we developed the color difference based on standard deviation (CDSD)method. Next we succeeded in extracting vascular structures in the tumors of less than 1 cm in diameter by high-frequency ultrasound (HF-US)system, nanobubbles (NBs), and the CDSD method. We applied the methodology to the lymphatic metastasis model, and found that it was applicable to early diagnostic and treatment evaluation of lymphatic metastasis.
Development of drug delivery system for central nervous system

TOMINAGA Teiji, HAYASE Toshiyuki, HAGA Youichi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (A)

Institution: Tohoku University

2009 - 2011

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This study aimed at developing novel brain interstitial drug delivery system for the treatment of central nervous system disorders. Recently we performed basic and clinical study using convection-enhanced delivery (CED). Convection-enhanced delivery (CED) is a local infusion technique that delivers various molecules to the central nervous system. We firstdeveloped real-time MRI guided monitoring system. In this system, we infuse the mixture of chemotherapeutic agent; ACNU with Gd-DTPA for real-time monitoring using MRI. Subsequently, we developed computational simulating system that predicts the distribution of Gd-DTPA in a brainstem of non-human primate. In addition, we developed a novel drug delivery apparatus.
超音波計測連成解析による超高精度生体機能計測システム

早瀬敏幸

Offer Organization: 科学技術振興機構

System: 産学が連携した研究開発成果の展開研究成果展開事業先端計測分析技術・機器開発プログラム一般領域機器開発タイプ

Institution: 東北大学

2006 - 2011

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小動物を用いた心臓循環器系の先端研究において、超音波計測結果とスーパーコンピュータ解析結果の差異を計算にフィードバックする新たな計測連成解析手法を開発し、循環器系疾患の機序や治療法の解明に不可欠な血流の3次元構造や壁せん断応力などの血流情報の精度を飛躍的に向上させます。本計測技術開発により、循環系や癌の先端研究が大いに進展することが期待されます。
Time-dependent blood flow analysis with measurement coupled simulation

HAYASE Toshiyuki, SHIRAI Atsushi, OHTA Makoto

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2007 - 2009

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This research was performed to develop a method for accurate reproduction of in vivo blood vessels and blood flow state by computer simulation to give feedback from the measurements of a medical ultrasonic diagnostic equipment even if the blood vessels in vivo conditions are unknown. The goal of this research is to contribute to the elucidation of the mechanism of cardiovascular diseases and treatments by analyzing the time dependence of the human body. Indicated possibilities can accurately assess the cardiovascular diseases of aging new combinations can predict atherosclerosis and vascular stenosis diagnosis indices became clear.
Topological Analysis and Advanced Visualization of Large-Scale, High-Order and Multi-Variate Datasets

FUJISHIRO Issei, TAKESHIMA Yuriko, TAKAHASHI Shigeo, HAYASE Toshiyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2006 - 2008
ナノバブルを用いたリアルタイム分子導入法の開発と腫瘍血管新生抑制治療への応用

小玉哲也, 小野栄夫, 早瀬敏幸, 藤川重雄

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 萌芽研究

Institution: 東北大学

2006 - 2007

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本研究は、EPR効果で固形腫瘍内の血管を流れ、漏出・滞留するナノバブルを超音波で破壊し、このとき発生するキャビテーション気泡の衝撃圧で血管壁周辺組織に治療性分子を導入し、「血管新生の抑制を目指す実時間超音波分子導入システムの開発」と「がん遺伝子治療」への応用を検証することを目的とする。本年度では脂質二重膜からで構成されたナノバブルに、ガスと液体を封入し、脂質二重膜には抗体を組み入れることが可能な、ナノサイズの音響性リポゾームを開発することに成功した。これにより、EPR効果で腫瘍新生血管から漏出・滞留するナノバブルを破壊することで封入された薬剤を局所的に血管壁近傍に導入することが可能な分子導入システムを開発した。またバブルの集積の輝度値で超音波を照射することが可能なトリガーシステムを開発し、当初予定していたスーパーコンピュータを介在させた分子デリバリーシステムが可能なった。バブルの移動軌跡は超音波画像として認識されるので、この移動軌跡を抽出することで二次元および三次元の血管構造を抽出することが可能になった。上記の血管壁への分子導入システムと血管構造抽出システムを併用することで、診断と治療が可能なリアルタイムな分子導入システムを構築することができた。
Optimum Control of Plasma Flow Systems through Multi-Scale Integration

NISHIYAMA Hideya, HAYASE Toshiyuki, SATO Takehiko, TOKUMASU Takashi, TAKANA Hidemasa

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (A)

Institution: Tohoku University

2005 - 2007

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In the present study, the plasma flow systems with multi-scale interactions are analyzed by using multi-scale control method and multi-scale integration to give the fundamental data for cold spray, plasma assist combustion, arc melting process and gas circuit breaker. The obtained results are as follows. 1. An integrated model for advanced cold spray process is constructed by integrating nano-micro particle flow model and coating formation model. It is clarified that electrostatic acceleration of nano-particle is effective in the presence of shock wave. The deposition process in the cavity is also clarified by comparing with cold spray experiment. 2. The pulsed arc torch and dielectric barrier discharge torch with small input power are developed to produce oxygen and nitrogen radicals and ozone for combustion assist. The effects of applied voltage and frequency on radical concentrations are clarified experimentally. Time evolution of chemical species in an air plasma are also clarified numerically using complex reaction model 3. Real time simulations are conducted for purpose of compactness of gas circuit breaker (GCB) and optimization of arc melting process. It is clarified that rough structure in the exhaust tube enhances the rapid cooling of exhaust hot gas for compact GCB. It is shown that the temperature dependent surface tension and mushy zone effect the melting pool structure in an arc-melting systems.
計測融合シミュレーションの理論的枠組みの構築

早瀬敏幸

Offer Organization: 日本学術振興会

System: 科学研究費助成事業萌芽研究

Category: 萌芽研究

Institution: 東北大学

2005 - 2006

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実現象の流れの数値シミュレーションと計測結果との誤差をシミュレーションに適切にフィードバックすることにより、シミュレーションの解析精度と計算速度が飛躍的に向上する。この計測融合シミュレーションは、計測と数値シミュレーション両手法の長所を兼ね備えた第3の研究手法として期待されている。これまで正方形管路内の乱流、一様流中におかれた角柱後流のカルマン渦列、大動脈内の血流の計測融合シミュレーションで、非定常流れの変動成分も含めた実現象の流れ場の再現が可能であることが示されている。しかしながら、流れの普遍的な解析手法として計測融合シミュレーションを用いるためには、その一般理論の構築が不可欠である。本研究は、非圧縮粘性流体を対象として、計測融合シミュレーションの一般的な定式化を行って、その収束性解析および誤差解析のための理論的枠組みを与えるとともに、数値実験により本理論の妥当性を検証することを目的として行った。本研究計画は、計測融合シミュレーションの一般理論の構築と、数値実験による検証の2つの研究項目よりなる。平成18年度に実施した研究は以下のとおりである。計測融合シミュレーションの実用問題への適用に関する検討を行った。臨床現場での血流計測に広く用いられている超音波診断装置では、血流速度の超音波ビーム方向の血流速度成分の血管断面内分布がリアルタイムで得られる。体循環系の血流を模擬できる実験装置を用いて超音波計測による計測を行って実験データを得た。超音波計測データを基に、従来の計測では得られない、血管内の三次元血流構造や圧力分布などを計測融合シミュレーションで高精度に再現するための最適フィードバック則を本理論に基づき決定するための検討を行い、本手法の有効性に関する知見を数値実験と実験の両面から得た。前年度に検討した線形フィードバック則の有効性を具体的な問題に適用し、その有効性を確認するための数値実験を行い、有用な知見を得た。
Transdisciplinary Research for Silent Supersonic Aircraft by Integrating Computation and Experiment

OBAYASHI Shigeru, HAYASE Toshiyuki, SASOH Akihiro, SAITOH Tsutomu, NAKAHASHI Kazuhiro, MATSUSHIMA Kisa

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (A)

Institution: TOHOKU UNIVERSITY

2003 - 2006

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One of the fundamental problems preventing commercial transport aircraft from supersonic flight is the generation of strong sonic booms. The strength of the shock waves generated by an aircraft flying at supersonic speed is a direct function of both the aircraft's weight and its occupying volume; it has been very difficult to sufficiently reduce the shock waves generated by the heavier and larger conventional supersonic transport (SST) configuration to meet acceptable at-ground sonic-boom levels. Our team first re-analyzed the classic Busemann biplane configurations to understand its basic wave cancellation concept using modern Computational Fluid Dynamics (CFD) tools. We then designed a two-dimensional (2-D) supersonic biplane that not only shows the desired aerodynamic characteristics at its design condition, but also outperforms a zero-thickness flat-plate airfoil. (Zero-thickness plat-plate airfoils are known as the most efficient monoplane airfoil at supersonic speeds.) Also we studied biplane performance not only at their design Mach numbers but also at off-design conditions. We extended the analysis to 3-D wing configurations as well. In parallel to the computational studies, we carried out series of experiments. The first experiment conducted here was the sonic boom experiment using gas gun. The N-wave was captured successfully. The second experiment was the 2 D wind tunnel test using Indraft Wind Tunnel Facility newly constructed in this research. In addition, conventional wind tunnel tests were conducted using existing wind tunnels. These experiments revealed important off-design flow features to be further studies by using CFD. The main research result is the development of the supersonic biplane theory. Biplane configuration allows canceling shock waves created by supersonic objects. It can be unconventional and innovative concept for future supersonic transport.
Multi-dimensional Nano Control of Plasma Flow Systems by Using Fusion

NISHIYAMA Hideya, HAYASE Toshiyuki, SATO Takehiko, TAKANA Hidemasa

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: TOHOKU UNIVERSITY

2003 - 2004

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‘Plasma Flow Integrated System' is successfully constructed by combining plasma flow with micor/nano particles, radicals and interface with complex interactions and further by integrating with senser and controller. The results obtained in the present study are as follows. (1)The effects of inlet flow rate ratios, swirling flow, gas injection location on needed input power for stable plasma generation and injected reactant gas flow rate are clarified for DC-RF hybrid plasma flow system. Furthermore, the effect of operating pressure on the in-flight characteristics and flow structure is clarified to provide the important element for multi-dimensional control. (2)Based on the statistically optimized DC-RF hybrid plasma flow system for photo-catalytic nano particle synthesis, particle size distribution and crystal structure can be controlled by inlet gas flow rate ratio and quench gas flow rate. (3)Multi-dimensional intelligent control system is developed to stabilize the argon/nitrogen plasma jet impinging onto the substrate for nitridation. Constant control of radiation intensity near substrate and suppression of plasma jet fluctuation are realized by operating back pressure and applied magnetic field. (4)The effects of seeding, applied frequency and trubulent characteristics on phase change and diameter decrease of micro particles are numerically clarified to control particle treatment by ICP with seeding potassium vapor. (5)The effects of quench gas flow rate, applied frequency and DC jet addition on nano particle size distribution for ICP are numerically clarified by realistic nano-particle synthesis model.
Development and operation of individual-based database system for biodiversity

KAWATA Masakado, KASUYA Eiichi, HAYASE Toshiyuki, YOKOYAMA Jun, HIRAYAMA Yoshiharu, MINAKA Nobuhiro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2001 - 2003

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We constructed new database system for biodiversity This system is based on our proposed philosophy that the unit for registration should be individuals. The unit of registration in the system is an individual organism, called an object. To register an object, and information on its traits, and to give the object a unique numerical code for later identification, a server computer is used. At registration, the object is unclassified, meaning that no subjective decision is made as to species or taxa, and no natural classification scheme is assumed. Using search keys, a search function allows registered objects to be retrieved based on morphological, phylogenetic, ecological and genetic traits, as well as on scientific, taxonomic, and common names. In general, the system includes not only machinery necessary for describing biodiversity, but also for extracting information pertaining to it. For testing the database we registered individual data for bamle bees.
Multi-sensing Control of Plasma Flow Systems Utilizing Super Functionalization

NISHIYAMA Hideya, RAMACHANDRAN Kandasamy, SATO Takehiko, HAYASE Toshiyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: TOHOKU UNIVERSITY

2001 - 2002

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The experimental and theoretical studies were carried out to establish a multi-sensing control systems for functional plasma flow by utilizing the applied magnetic effect and by seeding vaporized metal and reactive gas and further by injecting fine particles. The main results obtained here are as follows: (1) A multi-sensing control system for plasma jet stabilization was successfully established by controling the radiation intensity and by operating magnetic flux density. The constant value control performance of radiation intensity for sudden flow rate variation and further the control performance of plasma jet dynamic behavior for oscillating inlet flow rate were clarified experimentally. (2) The effects of applied frequency and seeding ratio of potassium on thermofluid field of inductivley coupled plasma and phase change of various kinds of metal powders injected were clarified by numerical simulation. (3) 3D multiphase plasma jet with carrier gas, particles and water droplet in dense loading were numerically analyzed by taking loading effect, phase change, variation of thermophysical properties, compressible effect and complex configuration into account. (4) Computational simulation for plasma spraying process, arc ash melting process and arc-electrodes system were conducted by developing strongly realistic model. The optimal operating conditions and plasma gun geometry were obtained to increase process efficiency and to extend life time. (5) DC-RF hybrid plasma systems were developed by super functionalization. The elongation of plasma flame and uniform temperature distribution were achieved by controlling the flow rate ratio of sheath gas to carrier gas. Furthermore, vortex flow structure in the coil zone was visualized by using PIV system.
毛細血管内におけるがん細胞流動の定量的な記述が可能なミクロ生体流動モデルの構築

早瀬敏幸, 白井敦

Offer Organization: 日本学術振興会

System: 科学研究費助成事業萌芽的研究

Category: 萌芽的研究

Institution: 東北大学

2000 - 2001

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毛細血管内の血流は,観察的研究により定性的には理解されているが,ミクロンオーダーの流動であるため計測が困難で,定量的データはほとんど得られていない。一方,拡大モデルによる流体工学的実験では,計測は可能であるが,生体内のミクロ流動の状況を再現しているとは言い難い。生体内のミクロな血流の定量的理解は,がん細胞の転移の正確な予測などにおいて極めて重要である。これを可能とするために,ミクロな生体組織による生体工学的実験と,流体工学的モデル実験とを融合し,さらに計算機による数値シミュレーションを援用して,新たな解析手法を確立する。この研究は,ミクロな生体流動現象を定量的に理解する新たな学問分野としての「ミクロ生体流体工学」を体系化するための基礎を確立することを目的とする。初年度の赤血球を用いた実験を異なる条件下で行うとともに,対応する数値解析を行って,実験と数値解析の両面から,ミクロ生体流動モデルの構築を行った。実験装置には,前年度同様,現有の傾斜遠心顕微鏡(倍率1,000倍,回転数10,000rpm)を用いた。回転速度と試料の取り付け角度を変化させながら細胞を観察することにより,赤血球とガラス板間の摩擦特性を計測した。血管内の流動数値解析には,東北大学流体科学研究所のスーパーコンピュータ(現有,SGI社製ORIGIN2000,256CPU)を用いた。実験により得られた細胞間の摩擦特性を数値解析結果と比較することにより,ミクロ生体流動の数学モデルを得た。
Intelligent Electromagnetic Control of Complex Interactions in Plasma Flow Systems

NISHIYAMA Hideya, SATO Takehiko, HAYASE Toshiyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B).

Institution: TOHOKU UNIVERSITY

1999 - 2000

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The experimental and theoretical studies were carried out to establish the intelligent electromagnetic control of plasma flow system, utilizing the complex interactions between plasma flow and mixed reactive gas and also injected fine particles. The main results obtained here are as follows : (1) A numerical model was proposed to clarify the complex plasma-particle-EM field in a pipe or complex configuration. The effects of RF EM field, particle injection and particle composition and nozzle angle on the plasma characteristics and particle behavior were clarified. (2) A virtual plasma spraying process was conducted using the above numerical model to clarify the optimum spraying conditions for high quality coating. (3) The effects of mixing gas on the plasma volume, radiation, and thermofluid field of nonequilibrium RF plasma were clarified experimentally. Furthermore, the effects of injection locations, inlet flow rates of chemical gases on the thermofluid field and species fields were clarified theoretically using multi-compoment model. (4) A feed back control system was successfully established by sensing the radiation and operating the discharge current, magnetic coil current. The control perfomance by changing discharge current or applying magnetic field was clarified.
Development of Hybrid Wind Tunnel Through Integration of Supercomputer and Experimental Wind Tunnel

HAYASE Toshiyuki, IKOHAGI Toshiaki, KOHAMA Yasuaki, HAYASHI Satoru, FUKUNISHI Yu, TAKAGI Toshiyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B).

Category: Grant-in-Aid for Scientific Research (B).

Institution: Tohoku University

1999 - 2000

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This research project aims to establish a new analysis methodology to complex flow problems. Through integration of numerical wind tunnel and experimental wind tunnel, a "Hybrid Wind Tunnel" was developed. First, an experimental wind tunnel was constructed and was connected to the supercomputer system of the Institute of Fluid Science, Tohoku University through a Gigabit Ethernet. As a fundamental flow field, Karman Vortex Street in the wake of a square column in a uniform flow was investigated. A pressure signal on a side wall of the column is fed back to the real-time computation to reduce the estimation error. After some transient, the computational result for the flow field converges to the real flow. The feedback law was optimized through numerical simulation and confirmed by experiment. Using pressure measurement on both sides of the square column, the computational result well converges to the real unsteady flow including the effect of perturbations initially existent in the main flow. Real time computation is essential in the hybrid wind tunnel and is explored through parallel computing. Blood flow control in living bodies and aerodynamic drag reduction of vehicles by feedback control are also investigated as possible application of hybrid wind tunnel.
Integrated Computational and Experimental Method for Flow Problems

HAYASE Toshiyuki, HAYASHI Satoru

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: TOHOKU UNIVERSITY

1998 - 1999

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Numerical analysis and experiment are common tools in flow analysis. Each of these methods, however, has own shortcomings. The result of numerical analysis inherently depends on the mathematical model and the computational grid. A consistent way of validation of numerical solutions has not been established yet. Evaluation of result is relatively easy in experiment, but it usually gives only limited information of the whole flow field. It is, therefore, desirable to establish a new analysis methodology in which the numerical and experimental methods are integrated to compensate their shortcomings. In the present research the concept of "observer" in automatic control theory is applied to flow problems. In the observer the state of the physical system in asymptotically estimated from the mathematical model to which the measurement data are fed back in real time. The SIMPLER-based numerical simulation algorithm is used as the mathematical model and the boundary condition and/or external force terms are modified based on the difference between the experimental measurement and computational result. Validity of the present flow observer was examined through numerical analysis for the turbulent flow in a square duct. Possibility in application to turbulent flow control was also studied. The fundamental grid convergence property of numerical methods, and characteristics of the collapsible tube flow system, in which the flow and the tube deformation interact, were investigated as the basic understandings of the future research. These results give fundamental information in establishing the new methodology to deal with especially complex flow problems to which conventional methods in experiment or computation do not apply effectively.
Microsystems Using Intelligent Materials

TANI Junji, HAGENA Otto, HAYASE Toshiyuki, TAKAGI Toshiyuki, HAYASHI Satoru, KOHL Manfred

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for international Scientific Research

Institution: Tohoku University

1995 - 1997

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The purpose of this research projects is to investigate the basic structures and performances of microsystems, such as microactuators, microsensors, etc. The research activity in this project focused on microfluidic actuators and microsystems using electromagnetically functional materials. For the purpose of an application of laminar proportional fluidic amplifier to micro-fluidics, a device controlling the low pressure is proposed and the static characteristics have been investigated. Application of micro-fluidcs to flow control problems has been investigated. Numerical analysis has been performed on the microcirculation of the human body as a fundamental consideration of bio-fluid control with micro-fluidics. Optimum condition of turbulent flow control with micro-valves has also been investigated via numerical analysis. Optical alignment technique using shape memory alloy (SMA) actuator was studied. It is shown that the SMA actuator is useful for precise optical alignment and for miniatureize the optical system.
Study of Dynamic Vibration Absorber Stabilizing a Circuit Pressure in a Water Hydraulic System

HAYASHI Satoru, IIMURA Ikuro, HAYASE Toshiyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

1995 - 1996

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The aim of this study is to obtain the stabilizing method of a high pressure water hydraulic supply system. The mathematical model has been derived as the system that the constant pump flow enters into a chamber which is connected with a poppet type safety valve, an output line terminated by a load restrictor, and accumulator as a dynamic absorber of vibration. The basic equations have been linearlized about the steady operating point. The effect of the main parameters on the system stability has been investigated by numerical simulation of the linearized equation and by experiment. Critical boundaries of stability are illustrated for the valve lift vs the supply pressure. Stability generally lowers as increase in the supply pressure. The damper installed to the valve shaft is particularly effective, and a sufficient damping coefficient can establish the complete stability over all region of the supply pressure. The complete stability is given also by a sufficient volume of the pump chamber. Addition of an accumulator evidently improves the system stability. The geometry of the tube connecting the accumulator and the pump chamber markedly affects the stability, whose diameter and length have the optima. The shape of stability boundaries is not simple because defferent modes of unstable characteristic roots switches as change of the operating point. A higher charging gas pressure gives a better stability, but the pulsation of the pump is eliminated by a lower charging pressure. The theoretical model has been proved to be valid from experimental results of the static characteristics, the stability boundaries, and from the chaotic waveforms due to collision of the valve against the valve seat. Therefore, useful basic knowledges have been obtained for stabilizing method and active vibration control of the direct operating poppet valve circuit as a water hydraulic pressure regulator, and furthermore, for developement of a balanced piston type relief valve for a water hydraulics.
Study of Acoustic Sounds by Computational and Experimental Fluid Dynamics

INOUE Osamu, TSUBOTA Makoto, SASOH Akihoro, HAYASE Toshiyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for General Scientific Research (B)

Institution: Tohoku University

1994 - 1995

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Acoustic sounds observed in four different fields of fluid dynamics are studied by four experts independently. Each expert in a field is supported by the other three experts in other fields who have different ideas, methods, know-hows and experiences, respectively. Inoue studied sounds produced by vortex-vortex interactions and shock wave-vortex interactions by 2D/3D direct Navier-Stokes simulations, and clarified the quadrupolar natures of sounds by the interactions. He also studied the 3D compressible flows around helicopter rotors and captured numerically vortex ring states and auto-rotation states for first time which are closely related to helicopter noises. Hayase studied numerically unsteady 2D flows in an orifice and also through spool valves, and showed that acoustic sound produced in these flows are closely related to the behavior of vortices. Sasoh studied experimentally tunnel sonic booms produced by highspeed trains, and showed that the booms are directly related to shock waves generated by entrance of a train in a long tunnel. Tsubota studied acoustic sounds in superfluid Helium and clarified that generation of quantized vortices is one of the sources of sounds in low temperature flow fields. The results obtained by the four experts are compared with each other. It is found that there are common natures among the sounds observed in spite of the difference of the flow fields studied ; for example, sounds produced by vortex-vortex interactions and vortex-sounds interactions have quadrupolar natures while dipolar property is predominant when obstacles or walls exist.
Positive Utilization of Nonlinearity of Fluid Control Systems

HAYASE Toshiyuki, IIMURA Ikuro, HAYASHI Satoru

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for General Scientific Research (C)

Category: Grant-in-Aid for General Scientific Research (C)

Institution: Tohoku University

1994 - 1995

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This research deals with fundamental research on positive utilization of the nonlinear characteristics of fluid control systems. Hydraulic control systems have advantages of high power and quick response but also have strong nonlinearity which prevents application of the modern linear control theory. Most hydraulic control systems have been designed through traditional PID control approach in which the nonlinearity of the system is ignored or the operation is restricted within a small linear range. However recent development of nonlinear control theory has enabled us to treat the nonlinear systems directly. As the typical example of such kind of problem, positioning of a hydraulic manipulator is investigated here using a specially designed hydraulic control system with strong nonlinear characteristics. A hydraulic motor is driven by a bridge circuit of four rotary valves each of which is controlled by a pulse motor. Based on a mathematical model of the system feedback linearization and conventional pole placement is applied to design the servo system. Numerical simulation and experiment were performed to confirm the validity of the present nonlinear hydraulic system in comparison with a traditional linear hydraulic control system. The present hydraulic manipulator has two degrees of freedom in its input. This provides the flexibility in control performance of the manipulator. Compliance control of the manipulator, which is essential in the man-machine interface environment, is easily realized. Optimization of the control valves applicable to the purpose of nonlinearity utilized hydraulic control systems is necessary based on the simulation of the 3-dimensional unsteady flow structure in the valves. As the fundamental consideration of this problem, unsteady calculation has been performed for the flow through the spool valve and its dynamic characteristics was investigated. Self-excited vibration due to nonlinearity is closely related to the control perfornance of the system. Experiment and numerical simulation has been performed for the fundamental hydraulic servo system and investigated on several types of the stick-slip vibrations which are generic to hydraulic control systems.
油圧制御弁の非線形挙動に関する研究

林叡, 飯村或郎, 早瀬敏幸

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 一般研究(C)

Institution: 東北大学

1994 - 1994

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油圧回路の圧力調整弁として多用されるポペット弁の非線形挙動を検討し,動作点が安定であっても大きな外乱が弁に加わると弁の非線形特性の影響によって,時として不安定振動が発生し(硬発振現象),この発振現象によってポペット弁回路の発振領域が著しく拡大することを示した. この回路の局所安定性(動作点の安定性)を検討した結果,弁モードと管路モードの不安定現象があることを明らかにし,前者は前開度が比較的大きい領域で,後者は弁リフトが比較的小さい領域で不安定になることを示した. この回路に発生する硬発振現象の発生機構は,弁リフトの大きな管路モードと弁リフトの小さな管路モードの場合では全く異なることを示し,弁開きの比較的大きな場合の硬発振現象が,弁静特性の非対称性に起因することを明らかにした. さらに,この種の弁では回路圧が弁の設定圧力より低い状態では,弁が弁座に着座した状態を安定に保つが,このような場合にも大きな外乱が弁に加わるとき不安定振動が発振し得ることを示し,この領域に発生する不安定振動が,時としてカオス的挙動を示すことを数値シミュレーション法によって明らかにした.弁回路に現れるカオス挙動は,いわゆる,ファイゲンバウム型のカオスで,供給圧力の増加とともに,周期倍分岐を繰り返しカオス領域に至ることを数値シミュレーションによって明らかにした. 弁のカオス挙動の数値解析に当たって,弁と弁座の衝突は不可避である.衝突点の計算精度が計算精度全体を左右するので,その適正な処理法である最適刻み細分化法を提案し,Runge-Kutta法の計算精度を損なわずに計算を遂行することに成功した.精度の良い数値シミュレーションが出来たのはこの計算法に負う所が大きい.これも本研究の成果である.
収束過程での流束の連続性が数値解析の安定性におよぼす影響について

早瀬敏幸

Offer Organization: 日本学術振興会

System: 科学研究費助成事業重点領域研究

Category: 重点領域研究

Institution: 東北大学

1993 - 1993

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平成5年度は,基本的な流れ場の1つである正方形管路内の乱流に関する数値解析を行なった.ただし従来の研究のように最終的な解を得ることのみを目的とするのではなく,境界面での流束の連続性と数値解析手法の安定性との関係について詳しく検討した.有限体積法に基づく反復計算の過程において,対流項の線形化手法によっては有限体積要素境界を通過する流束が不連続となり,その結果数値計算は不安定となる.収束過程での流束の連続性を数値解析手法の満たすべき基本的な条件として検討した結果,対流項を1次の風上法とその修正量の形で表現して線形化するという,従来より数値解法の安定化に有効であることが指摘されてはいるが,その物理的意味づけが明確ではなかった定式化が対流項の線形化の一般的な条件として得られた.この線形化の手法を用いて正方形管内の乱流の数値解析を行った.対流項の離散化には中心差分法と3次の風上差分であるQUICKスキームを用いて計算を行い,格子解像度の変化に対する収束性の比較を行った.従来の数値解析においては中心差分法は格子レイノルズ数の制約から粗い計算格子で解を得ることは困難であったが,本線形化手法により任意の格子で高レイノルズ数の解を得ることができるようになった.種々の格子解像度について系統的な計算を行った結果,中心差分法とQUICKスキームでは収束性に本質的な差異が存在することが明らかとなった. 上記の基本的な流れ場に対する検討に加えて,情報機器においてレーザービームの高速走査に多用される回転多角形ミラー周りの乱流場の数値解析,流体制御機器内の非定常流に関する数値解析も行って対象とした複雑な流れ場に関する知見を得た.

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Teaching Experience 2

Intelligent Mechano-system Analysis　Tohoku University
Control Engineering Ⅱ　Tohoku University, Faculty of Engineering Undergraduate (specialized)

Works 1

A GENERAL COMPUTER PROGRAM FOR THREE-DIMENSIONAL FLOW AND HEAT TRANSFER, ROTFLO2

Toshiyuki Hayase, Joseph A. C. Humphrey, Ralph Greif

1991/10/31 -

Type: Software

Social Activities 1

日本宇宙少年団仙台たなばた分団

2008/04/01 - 2014/03/31

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日本宇宙少年団仙台たなばた分団分団長として青少年の育成に協力している。

Media Coverage 6

東北大学の新世紀計測と計算の融合が命を救う

東日本放送

2007/10/22

Type: TV or radio program
シリーズ東北大学１００年物語世界唯一のスパコンで動脈瘤を解明へ

仙台放送

2006/06/26

Type: TV or radio program
流れの圧力・速度リアルタイムに再現

日刊工業新聞

2005/03/16

Type: Newspaper, magazine
ウオッチンミヤギ

東北放送

2005/01/25

Type: TV or radio program

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ハイブリッド風洞を用いたカルマン渦の計測融合シミュレーションが紹介された
非観血式血圧測定計精度向上の新技術

日刊工業新聞

2004/09/14

Type: Newspaper, magazine
生体内の血流構造再現、超音波診断装置とスパコン融合、シミュレーション装置開発

日刊工業新聞

2003/06/10

Type: Newspaper, magazine

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Academic Activities 1

Third International Symposium on Advanced Fluid Information, AFI 2003

2003/11/21 - 2003/11/22

Activity type: Competition, symposium, etc.

Other 11

MR画像計測に基づく心臓・大動脈系の血流場の数値解析

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MR画像計測に基づく心臓・大動脈系の血流場の数値解析を行って動脈瘤などの循環器系疾患の発生機序を解明する。
傾斜遠心力場における平板上の赤血球挙動の数値解析

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傾斜遠心力場における平板上の赤血球の挙動を数値解析により解明する。
パルプ流れの計測融合シミュレーション

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パルプ流れの計測融合シミュレーションを行なう。
超音波計測連成解析による超高精度生体機能計測システム

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本研究開発は、小動物を用いた心臓循環器系の先端研究において、超音波計測結果とスーパーコンピュータ解析結果の差異を計算にフィードバックする新たな計測連成解析手法を開発し、循環器系疾患の機序や治療法の解明に不可欠な血流の３次元構造や壁せん断応力などの血流情報の精度を飛躍的に向上させる。本計測技術開発により、循環系や癌の先端研究が大いに進展することが期待される。
リンパの超音波計測融合シミュレーション

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リンパの流れを超音波計測融合シミュレーションで明らかにする
非定常流れ場のPIV計測融合シミュレーションと生体流動制御

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非定常流れ場のPIV計測融合シミュレーションと生体流動制御の研究を行なう。
がん細胞の摩擦特性

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傾斜遠心顕微鏡によりがん細胞の摩擦特性を明らかにする
超音波計測融合シミュレーション

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超音波計測と数値シミュレーションを融合し血流動態を解明する
Virtual Measurement and Control of Flow

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流れ場の仮想計測と制御に関する共同研究を行なう。
Numerical Simulation of Flow in Branch

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分岐管内流れの数値解析を行なう。
Numerical Simulation of Flow Around Magnetic Micromachine

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数値解析により磁気マイクロマシンの最適設計を行った

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