Details of the Researcher

PHOTO

Tatsuo Yoshinobu
Section
Graduate School of Biomedical Engineering
Job title
Professor
Degree

  • 博士（工学）（京都大学）

  • 工学修士（京都大学）

Research History 6

  • 2008/04 - Present
    Tohoku University　Graduate School of Biomedical Engineering　Professor

  • 2005/04 - 2008/03
    Tohoku University　Department of Electronic Engineering　Professor

  • 2001/11 - 2005/03
    Osaka University　The Institute of Scientific and Industrial Research　Associate Professor

  • 1996/04 - 2001/10
    Osaka University　The Institute of Scientific and Industrial Research　Lecturer

  • 1999/05 - 2000/04
    Research Centre Jülich, Germany　Institute of Thin Film and Ion Technology　Visiting Scientist

  • 1992/04 - 1996/03
    Osaka University　The Institute of Scientific and Industrial Research　Research Associate

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Education 3

  • Kyoto University　Graduate School of Engineering　Department of Electrical Engineering II

    1989/04 - 1992/03

  • Kyoto University　Graduate School of Engineering　Department of Electrical Engineering II

    1987/04 - 1989/03

  • Kyoto University　Faculty of Engineering　Department of Electrical Engineering II

    1983/04 - 1987/03

Professional Memberships 4

  • The Institute of Electrical Engineers of Japan

  • The Surface Science Society of Japan

  • Japan Association of Chemical Sensors, The Electrochemical Society of Japan

  • The Japan Society of Applied Physics

Research Interests 2

  • biosensors

  • chemical sensors

Research Areas 3

  • Nanotechnology/Materials / Analytical chemistry /

  • Manufacturing technology (mechanical, electrical/electronic, chemical engineering) / Electronic devices and equipment /

  • Life sciences / Biomedical engineering /

Papers 240

  1. Silk‐Fibroin as Biocompatible and Bioresorbable Enzyme Immobilization Matrix for Screen‐Printed Amperometric Glucose Biosensors Peer-reviewed

    Kevin A. Janus, Stefan Achtsnicht, Benedetta Isella, Alexander Kopp, Koichiro Miyamoto, Tatsuo Yoshinobu, Michael Keusgen, Michael J. Schöning

    Advanced Sensor Research　2025/06/18

    Publisher: Wiley

    DOI： 10.1002/adsr.202500048 　

    ISSN： 2751-1219

    eISSN： 2751-1219

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    Abstract Silk‐fibroin is utilized as a biocompatible and bioresorbable enzyme immobilization matrix and exemplarily demonstrated for a screen‐printed amperometric glucose biosensor. The silk‐fibroin is derived from the silkworm Bombyx mori. The enzyme immobilization matrix consisting of silk‐fibroin, together with glucose oxidase from Aspergillus niger, is applied to a screen‐printed carbon‐based, biocompatible, and biodegradable working electrode on a flexible silk‐fibroin substrate. The biosensor is characterized electrochemically at physiological glucose concentrations in the range from 0.5 to 10 mm. The results are compared to a “conventional” glucose biosensor, also fabricated on a flexible silk‐fibroin substrate, however utilizing a laboratory standard enzyme immobilization matrix based on bovine serum albumin and glutaraldehyde. Furthermore, the influence of pH (pH 5.5 to pH 8.0) and temperature variations (21 to 70 °C) on these two different immobilization matrices are studied.

  2. Advancing multiplexed ion monitoring techniques: The development of integrated thermally drawn polymer fiber-based ion probes Peer-reviewed

    Jingxuan Wu, Tomoki Saizaki, Tatsuo Yoshinobu, Yuanyuan Guo

    Talanta　285　127249-127249　2025/04

    Publisher: Elsevier BV

    DOI： 10.1016/j.talanta.2024.127249 　

    ISSN： 0039-9140

  3. Nanograting Microring Optical Resonators for Enhanced Refractive Index Sensitivity

    Anh Igarashi, Yasuo Ohtera, Tatsuo Yoshinobu, Hirohito Yamada

    IEEE Sensors Letters　1-4　2025

    Publisher: Institute of Electrical and Electronics Engineers (IEEE)

    DOI： 10.1109/lsens.2025.3585131 　

    eISSN： 2475-1472

  4. Control Circuits for Potentiostatic/Galvanostatic Polarization and Simultaneous Chemical Sensing by a Light-Addressable Potentiometric Sensor Peer-reviewed

    Tatsuo Yoshinobu, Rintaro Ikeda, Ko-ichiro Miyamoto

    Sensors　24　(17)　5666-5666　2024/08/30

    Publisher: MDPI AG

    DOI： 10.3390/s24175666 　

    eISSN： 1424-8220

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    A light-addressable potentiometric sensor (LAPS) is a semiconductor-based sensor platform for sensing and imaging of various chemical species. Being a potentiometric sensor, no faradaic current flows through its sensing surface, and no electrochemical reaction takes place in the course of LAPS measurement. In this study, a four-electrode system is proposed, in which a LAPS is combined with the conventional three-electrode electrochemical system. A LAPS is included as the fourth electrode for potentiometric sensing and imaging of the target analyte in the course of an electrochemical reaction taking place on the surface of the working electrode. The integrated system will be useful for analyzing dynamic processes, where both the electrochemical process on the electrode surface and the ion distribution in the solution need to be simultaneously investigated. Different grounding modes of control circuits that can simultaneously conduct potentiostatic/galvanostatic polarization and LAPS measurement are designed, and their functionalities are tested. The interference between polarization and LAPS measurement will also be discussed.

  5. Loose Ag-Doped LaFeO₃ Nanotubes-Based Gas Sensor for Excellent Acetic Acid Sensing Peer-reviewed

    Jingxuan Wu, Yu Wan, Zhenxing Wang, Yimu Wang, Qingsong Luo, Changhao Feng, Tatsuo Yoshinobu

    IEEE Sensors Journal　24　(5)　5821-5829　2024/03/01

    Publisher: Institute of Electrical and Electronics Engineers (IEEE)

    DOI： 10.1109/jsen.2024.3350873 　

    ISSN： 1530-437X

    eISSN： 1558-1748 2379-9153

  6. Field-Effect Sensors Combined with the Scanned Light Pulse Technique: From Artificial Olfactory Images to Chemical Imaging Technologies Peer-reviewed

    Tatsuo Yoshinobu, Ko-ichiro Miyamoto, Torsten Wagner, Michael J. Schöning

    Chemosensors　12　(2)　20-20　2024/01/28

    Publisher: MDPI AG

    DOI： 10.3390/chemosensors12020020 　

    eISSN： 2227-9040

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    The artificial olfactory image was proposed by Lundström et al. in 1991 as a new strategy for an electronic nose system which generated a two-dimensional mapping to be interpreted as a fingerprint of the detected gas species. The potential distribution generated by the catalytic metals integrated into a semiconductor field-effect structure was read as a photocurrent signal generated by scanning light pulses. The impact of the proposed technology spread beyond gas sensing, inspiring the development of various imaging modalities based on the light addressing of field-effect structures to obtain spatial maps of pH distribution, ions, molecules, and impedance, and these modalities have been applied in both biological and non-biological systems. These light-addressing technologies have been further developed to realize the position control of a faradaic current on the electrode surface for localized electrochemical reactions and amperometric measurements, as well as the actuation of liquids in microfluidic devices.

  7. Enhanced acetone sensing properties of W-doped ZnFe2O4 electrospinning nanofibers Peer-reviewed

    Jingxuan Wu, Song Zou, Bo Wang, Changhao Feng, Tatsuo Yoshinobu

    Journal of Alloys and Compounds　938　168440-168440　2023/03

    Publisher: Elsevier BV

    DOI： 10.1016/j.jallcom.2022.168440 　

    ISSN： 0925-8388

  8. Thermally Drawn CNT-Based Hybrid Nanocomposite Fiber for Electrochemical Sensing Peer-reviewed

    Rino Nishimoto, Yuichi Sato, Jingxuan Wu, Tomoki Saizaki, Mahiro Kubo, Mengyun Wang, Hiroya Abe, Inès Richard, Tatsuo Yoshinobu, Fabien Sorin, Yuanyuan Guo

    Biosensors　12　(8)　559-559　2022/07/24

    Publisher: MDPI AG

    DOI： 10.3390/bios12080559 　

    eISSN： 2079-6374

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    Nowadays, bioelectronic devices are evolving from rigid to flexible materials and substrates, among which thermally-drawn-fiber-based bioelectronics represent promising technologies thanks to their inherent flexibility and seamless integration of multi-functionalities. However, electrochemical sensing within fibers remains a poorly explored area, as it imposes new demands for material properties—both the electrochemical sensitivity and the thermomechanical compatibility with the fiber drawing process. Here, we designed and fabricated microelectrode fibers made of carbon nanotube (CNT)-based hybrid nanocomposites and further evaluated their detailed electrochemical sensing performances. Carbon-black-impregnated polyethylene (CB-CPE) was chosen as the base material, into which CNT was loaded homogeneously in a concentration range of 3.8 to 10 wt%. First, electrical impedance characterization of CNT nanocomposites showed a remarkable decrease of the resistance with the increase in CNT loading ratio, suggesting that CNTs notably increased the effective electrical current pathways inside the composites. In addition, the proof-of-principle performance of fiber-based microelectrodes was characterized for the detection of ferrocenemethanol (FcMeOH) and dopamine (DA), exhibiting an ultra-high sensitivity. Additionally, we further examined the long-term stability of such composite-based electrode in exposure to the aqueous environment, mimicking the in vivo or in vitro settings. Later, we functionalized the surface of the microelectrode fiber with ion-sensitive membranes (ISM) for the selective sensing of Na+ ions. The miniature fiber-based electrochemical sensor developed here holds great potential for standalone point-of-care sensing applications. In the future, taking full advantage of the thermal drawing process, the electrical, optical, chemical, and electrochemical modalities can be all integrated together within a thin strand of fiber. This single fiber can be useful for fundamental multi-mechanistic studies for biological applications and the weaved fibers can be further applied for daily health monitoring as functional textiles.

  9. Efficient Illumination for a Light-Addressable Potentiometric Sensor Peer-reviewed

    Tatsuo Yoshinobu, Ko-ichiro Miyamoto

    SENSORS　22　(12)　2022/06

    DOI： 10.3390/s22124541 　

    eISSN： 1424-8220

  10. Simultaneous In Situ Imaging of pH and Surface Roughening during the Progress of Crevice Corrosion of Stainless Steel Peer-reviewed

    Ko-ichiro Miyamoto, Rinya Hiramitsu, Carl Frederik Werner, Tatsuo Yoshinobu

    Sensors　22　(6)　2246-2246　2022/03/14

    Publisher: MDPI AG

    DOI： 10.3390/s22062246 　

    eISSN： 1424-8220

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    Stainless steel plays an important role in industry due to its anti-corrosion characteristic. It is known, however, that local corrosion can damage stainless steel under certain conditions. In this study, we developed a novel measurement system to observe crevice corrosion, which is a local corrosion that occurs inside a narrow gap. In addition to pH imaging inside the crevice, another imaging technique using an infrared light was combined to simultaneously visualize surface roughening of the test piece. According to experimental results, the lowering of local pH propagated inside the crevice, and after that, the surface roughening started and expanded due to propagation of corrosion. The real-time measurement of the pH distribution and the surface roughness can be a powerful tool to investigate the crevice corrosion.

  11. Thermally-Drawn Multi-Electrode Fibers for Bipolar Electrochemistry and Magnified Electrochemical Imaging Peer-reviewed

    Tomoki Iwama, Yuanyuan Guo, Shoma Handa, Kumi Y. Inoue, Tatsuo Yoshinobu, Fabien Sorin, Hitoshi Shiku

    ADVANCED MATERIALS TECHNOLOGIES　2021/11

    DOI： 10.1002/admt.202101066 　

    ISSN： 2365-709X

  12. Detection of Hydrogen Permeation through Pure Iron with Light-addressable Potentiometric Sensor Peer-reviewed

    Ko-ichiro Miyamoto, Manato Kaneko, Mengyun Wang, Carl Frederik Werner, Tatsuo Yoshinobu

    ISIJ International　61　(4)　1330-1332　2021/04/15

    Publisher: Iron and Steel Institute of Japan

    DOI： 10.2355/isijinternational.isijint-2020-560 　

    ISSN： 0915-1559

    eISSN： 1347-5460

  13. Consideration of Repassivation Process Based on the Measurement pH in Crevice and Metal Dissolution Rate of SUS304 Stainless Steel in Artificial Seawater Peer-reviewed

    Kiyomi Nose, Ryo Matsuhashi, Haruhiko Kajimura, Ko-ichiro Miyamoto, Tatsuo Yoshinobu

    Zairyo-to-Kankyo　70　(4)　131-139　2021/04/10

    Publisher: Japan Society of Corrosion Engineering

    DOI： 10.3323/jcorr.70.131 　

    ISSN： 0917-0480

    eISSN： 1881-9664

  14. Miniature multiplexed label-free pH probe in vivo Peer-reviewed

    Yuanyuan Guo, Carl Frederik Werner, Shoma Handa, Mengyun Wang, Tomokazu Ohshiro, Hajime Mushiake, Tatsuo Yoshinobu

    Biosensors and Bioelectronics　174　112870-112870　2020/11

    Publisher: Elsevier BV

    DOI： 10.1016/j.bios.2020.112870 　

    ISSN： 0956-5663

  15. Estimation of Potential Distribution during Crevice Corrosion through Analysis of I–V Curves Obtained by LAPS Peer-reviewed

    Kiyomi Nose, Ko-ichiro Miyamoto, Tatsuo Yoshinobu

    Sensors　20　(10)　2873-2873　2020/05/19

    DOI： 10.3390/s20102873 　

    eISSN： 1424-8220

  16. The pH in Crevice Measured by a Semiconductor Chemical Sensor and Relationship with Crevice Corrosion Behavior of Stainless Steel Peer-reviewed

    Kiyomi Nose, Haruhiko Kajimura, Ko-ichiro Miyamoto, Tatsuo Yoshinobu

    Zairyo-to-Kankyo　69　(2)　40-48　2020/02/10

    Publisher: Japan Society of Corrosion Engineering

    DOI： 10.3323/jcorr.69.40 　

    ISSN： 0917-0480

    eISSN： 1881-9664

  17. Polymer-fiber-coupled field-effect sensors for label-free deep brain recordings Peer-reviewed

    Y. Guo, C.F. Werner, A. Canales, L. Yu, X. Jia, P. Anikeeva, T. Yoshinobu

    PLOS ONE　15　(1)　2020/01

    DOI： 10.1371/journal.pone.0228076 　

  18. Modeling of the Return Current in a Light-Addressable Potentiometric Sensor Peer-reviewed

    Tatsuo Yoshinobu, Daisuke Sato, Yuanyuan Guo, Carl Frederik Werner, Ko-ichiro Miyamoto

    Sensors　19　(20)　4566-1-4566-12　2019/10

    DOI： 10.3390/s19204566 　

    eISSN： 1424-8220

  19. A Gas-Sensitive SPIM Sensor for Detection of Ethanol Using SnO2 as Sensing Element Peer-reviewed

    Mengyun Wang, Hoang A. Truong, Carl F. Werner, Ko ichiro Miyamoto, Tatsuo Yoshinobu

    Physica Status Solidi (A) Applications and Materials Science　216　(12)　2019/06/19

    DOI： 10.1002/pssa.201800766 　

    ISSN： 1862-6300

    eISSN： 1862-6319

  20. Multi-Well Sensor Platform Based on a Partially Etched Structure of a Light-Addressable Potentiometric Sensor Peer-reviewed

    Hoang Anh Truong, Carl Frederik Werner, Ko ichiro Miyamoto, Tatsuo Yoshinobu

    Physica Status Solidi (A) Applications and Materials Science　216　(12)　2019/06

    DOI： 10.1002/pssa.201800764 　

    ISSN： 1862-6300

    eISSN： 1862-6319

  21. Imaging detection of ethanol vapor by scanning photo-induced impedance microscopy with suspended-gate structure Peer-reviewed

    Mengyun Wang, Hoang Anh Truong, Carl Frederik Werner, Ko Ichiro Miyamoto, Tatsuo Yoshinobu

    ISOEN 2019 - 18th International Symposium on Olfaction and Electronic Nose, Proceedings　2019/05

    DOI： 10.1109/ISOEN.2019.8823159 　

  22. Sensors and techniques for visualization and characterization of local corrosion Peer-reviewed

    Ko Ichiro Miyamoto, Tatsuo Yoshinobu

    Japanese Journal of Applied Physics　58　2019/01

    DOI： 10.7567/1347-4065/ab01da 　

    ISSN： 0021-4922

  23. Improved Spatial Resolution of the Chemical Imaging Sensor with a Hybrid Illumination That Suppresses Lateral Diffusion of Photocarriers Peer-reviewed

    K. Miyamoto, K. Seki, T. Suto, C. F. Werner, T. Wagner, M. J. Schöning, T. Yoshinobu

    Sensors and Actuators, B: Chemical　273　1328-1333　2018/11

    DOI： 10.1016/j.snb.2018.07.016 　

    ISSN： 0925-4005

    eISSN： 0925-4005

  24. A Modified Chemical Imaging Sensor System for Real-Time pH Imaging of Accelerated Crevice Corrosion of Stainless Steel Peer-reviewed

    Ko ichiro Miyamoto, Sakura Sakakita, Carl Frederik Werner, Tatsuo YoshinobuK. Miyamoto, S. Sakakita, C. F. Werner, T. Yoshinobu

    Physica Status Solidi (A) Applications and Materials Science　215　(15)　2018/08

    DOI： 10.1002/pssa.201700963 　

    ISSN： 1862-6300

    eISSN： 1862-6319

  25. A Partially Etched Structure of Light-Addressable Potentiometric Sensor for High-Spatial-Resolution and High-Speed Chemical Imaging Peer-reviewed

    H. A. Truong, C. F. Werner, K. Miyamoto, T. Yoshinobu

    Physica Status Solidi (A) Applications and Materials Science　215　(15)　2018/08

    DOI： 10.1002/pssa.201700964 　

    ISSN： 1862-6300

    eISSN： 1862-6319

  26. Light-addressable potentiometric sensors for (bio-)chemical sensing and imaging

    M. J. Schöning, T. Wagner, A. Poghossian, K. I. Miyamoto, C. F. Werner, S. Krause, T. Yoshinobu

    Encyclopedia of Interfacial Chemistry: Surface Science and Electrochemistry　295-308　2018/01/01

    Publisher: Elsevier

    DOI： 10.1016/B978-0-12-409547-2.13483-3 　

  27. Lateral resolution enhancement of pulse-driven light-addressable potentiometric sensor Peer-reviewed

    Carl Frederik Werner, Ko-ichiro Miyamoto, Torsten Wagner, Michael J. Schoening, Tatsuo Yoshinobu

    SENSORS AND ACTUATORS B-CHEMICAL　248　961-965　2017/09

    DOI： 10.1016/j.snb.2017.02.057 　

    ISSN： 0925-4005

  28. A bubble-assisted electroosmotic micropump for a delivery of a droplet in a microfluidic channel combined with a light-addressable potentiometric sensor Peer-reviewed

    Xueliang Li, Shibin Liu, Pingping Fan, Carl Frederik Werner, Ko-ichiro Miyamoto, Tatsuo Yoshinobu

    SENSORS AND ACTUATORS B-CHEMICAL　248　993-997　2017/09

    DOI： 10.1016/j.snb.2017.02.165 　

    ISSN： 0925-4005

  29. A high-Q resonance-mode measurement of EIS capacitive sensor by elimination of series resistance Peer-reviewed

    Ko-ichiro Miyamoto, Kosuke Hayashi, Azuma Sakamoto, Carl Frederik Werner, Torsten Wagner, Michael J. Schoening, Tatsuo Yoshinobu

    SENSORS AND ACTUATORS B-CHEMICAL　248　1006-1010　2017/09

    DOI： 10.1016/j.snb.2017.03.002 　

    ISSN： 0925-4005

  30. Restraining the Diffusion of Photocarriers to Improve the Spatial Resolution of the Chemical Imaging Sensor

    K. Miyamoto, T. Suto, C. F. Werner, T. Wagner, M. J. Schöning, T. Yoshinobu

    MDPI Proceedings　1　(4)　471-1-471-4　2017/08

    DOI： 10.3390/proceedings1040477 　

  31. Polymer Composite with Carbon Nanofibers Aligned during Thermal Drawing as a Microelectrode for Chronic Neural Interfaces Peer-reviewed

    Yuanyuan Guo, Shan Jiang, Benjamin J. B. Grena, Ian F. Kimbrough, Emily G. Thompson, Yoel Fink, Harald Sontheimer, Tatsuo Yoshinobu, Xiaoting Jia

    ACS NANO　11　(7)　6574-6585　2017/07

    DOI： 10.1021/acsnano.6b07550 　

    ISSN： 1936-0851

    eISSN： 1936-086X

  32. Light-Addressable Potentiometric Sensors for Quantitative Spatial Imaging of Chemical Species Peer-reviewed

    Tatsuo Yoshinobu, Ko-ichiro Miyamoto, Carl Frederik Werner, Arshak Poghossian, Torsten Wagner, Michael J. Schöning

    Annual Review of Analytical Chemistry　10　(1)　225-246　2017/06/12

    DOI： 10.1146/annurev-anchem-061516-045158 　

    ISSN： 1936-1327

    eISSN： 1936-1335

  33. 化学イメージセンサの開発とその応用 Invited

    吉信達夫

    化学工業　68　(6)　389-394　2017/06/01

    Publisher:

    ISSN： 0451-2014

  34. Towards addressability of light-addressable potentiometric sensors: Shunting effect of non-illuminated region and cross-talk Peer-reviewed

    A. Poghossian, C. F. Werner, V. V. Buniatyan, T. Wagner, K. Miamoto, T. Yoshinobu, M. J. Schoening

    SENSORS AND ACTUATORS B-CHEMICAL　244　1071-1079　2017/06

    DOI： 10.1016/j.snb.2017.01.047 　

    ISSN： 0925-4005

  35. An on-chip electroosmotic micropump with a light- addressable potentiometric sensor Peer-reviewed

    Xue-liang Li, Shi-bin Liu, Ping-ping Fan, Carl Frederik Werner, Koichiro Miyamoto, Tatsuo Yoshinobu

    Optoelectronics Letters　13　(2)　113-115　2017/03/01

    Publisher: Springer Verlag

    DOI： 10.1007/s11801-017-6264-x 　

    ISSN： 1993-5013 1673-1905

  36. Visualization of the recovery process of defects in a cultured cell layer by chemical imaging sensor Peer-reviewed

    Ko-ichiro Miyamoto, Bing Yu, Hiroko Isoda, Torsten Wagner, Michael J. Schoening, Tatsuo Yoshinobu

    SENSORS AND ACTUATORS B-CHEMICAL　236　965-969　2016/11

    DOI： 10.1016/j.snb.2016.04.018 　

    ISSN： 0925-4005

  37. Light-Addressable Potentiometric Sensor as a Sensing Element in Plug-Based Microfluidic Devices Peer-reviewed

    Ko-Ichiro Miyamoto, Takuya Sato, Minami Abe, Torsten Wagner, Michael J. Schoening, Tatsuo Yoshinobu

    MICROMACHINES　7　(7)　111-1-111-8　2016/07

    DOI： 10.3390/mi7070111 　

    ISSN： 2072-666X

  38. Application of electroosmotic micropumps to a microfluidic system combined with a light-addressable potentiometric sensor Peer-reviewed

    Xueliang Li, Shibin Liu, Jintao Liang, Ko-ichiro Miyamoto, Tatsuo Yoshinobu

    PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE　213　(6)　1500-1504　2016/06

    DOI： 10.1002/pssa.201532879 　

    ISSN： 1862-6300

    eISSN： 1862-6319

  39. Light-addressable potentiometric sensor (LAPS) combined with magnetic beads for pharmaceutical screening Peer-reviewed

    Torsten Wagner, Wolfgang Vornholt, Carl Frederik Werner, Tatsuo Yoshinobu, Ko-ichiro Miyamoto, Michael Keusgen, Michael J. Schöning

    Physics in Medicine　1　2-7　2016/06/01

    Publisher: Elsevier B.V.

    DOI： 10.1016/j.phmed.2016.03.001 　

    ISSN： 2352-4510

  40. A Novel Data Acquisition Method for Visualization of Large pH Changes by Chemical Imaging Sensor Peer-reviewed

    Ko-ichiro Miyamoto, Sakura Sakakita, Tatsuo Yoshinobu

    ISIJ INTERNATIONAL　56　(3)　492-494　2016

    DOI： 10.2355/isijinternational.ISIJINT-2015-330 　

    ISSN： 0915-1559

    eISSN： 1347-5460

  41. Development and Bio-imaging Applications of a Chemical Imaging Sensor Peer-reviewed

    Ko-ichiro Miyamoto, Tatsuo Yoshinobu

    SENSORS AND MATERIALS　28　(10)　1091-1104　2016

    DOI： 10.18494/SAM.2016.1364 　

    ISSN： 0914-4935

  42. Application of chemical imaging sensor to in-situ pH imaging in the vicinity of a corroding metal surface Peer-reviewed

    Ko-ichiro Miyamoto, Sakura Sakakita, Torsten Wagner, Michael J. Schoening, Tatsuo Yoshinobu

    ELECTROCHIMICA ACTA　183　137-142　2015/11

    DOI： 10.1016/j.electacta.2015.07.184 　

    ISSN： 0013-4686

    eISSN： 1873-3859

  43. Recent developments of chemical imaging sensor systems based on the principle of the light-addressable potentiometric sensor Peer-reviewed

    Tatsuo Yoshinobu, Ko-ichiro Miyamoto, Torsten Wagner, Michael J. Schoening

    SENSORS AND ACTUATORS B-CHEMICAL　207　926-932　2015/02

    DOI： 10.1016/j.snb.2014.09.002 　

    ISSN： 0925-4005

  44. Visualization of defects on a cultured cell layer by utilizing chemical imaging sensor

    Ko-ichiro Miyamoto, Yu Bing, Torsten Wagner, Tatsuo Yoshinobu, Michael J. Schoening

    EUROSENSORS 2015　120　936-939　2015

    DOI： 10.1016/j.proeng.2015.08.806 　

    ISSN： 1877-7058

  45. Device simulation of the light-addressable potentiometric sensor for the investigation of the spatial resolution Peer-reviewed

    Yuanyuan Guo, Ko-ichiro Miyamoto, Torsten Wagner, Micheal J. Schoening, Tatsuo Yoshinobu

    SENSORS AND ACTUATORS B-CHEMICAL　204　659-665　2014/12

    DOI： 10.1016/j.snb.2014.08.016 　

    ISSN： 0925-4005

  46. Theoretical study and simulation of light-addressable potentiometric sensors Peer-reviewed

    Yuanyuan Guo, Ko-ichiro Miyamoto, Torsten Wagner, Michael J. Schoening, Tatsuo Yoshinobu

    PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE　211　(6)　1467-1472　2014/06

    DOI： 10.1002/pssa.201330354 　

    ISSN： 1862-6300

    eISSN： 1862-6319

  47. Novel photoexcitation method for light-addressable potentiometric sensor with higher spatial resolution Peer-reviewed

    Yuanyuan Guo, Kosuke Seki, Ko-ichiro Miyamoto, Torsten Wagner, Michael J. Schoening, Tatsuo Yoshinobu

    APPLIED PHYSICS EXPRESS　7　(6)　067301-1-067301-4　2014/06

    DOI： 10.7567/APEX.7.067301 　

    ISSN： 1882-0778

    eISSN： 1882-0786

  48. High-speed chemical imaging inside a microfluidic channel Peer-reviewed

    Ko-ichiro Miyamoto, Akinori Itabashi, Torsten Wagner, Michael J. Schoening, Tatsuo Yoshinobu

    SENSORS AND ACTUATORS B-CHEMICAL　194　521-527　2014/04

    DOI： 10.1016/j.snb.2013.12.090 　

    ISSN： 0925-4005

  49. Enhancement of the Spatial Resolution of the Chemical Imaging Sensor by a Hybrid Fiber-Optic Illumination Peer-reviewed

    K. Miyamoto, K. Seki, Y. Guo, T. Wagner, M. J. Schoening, T. Yoshinobu

    28TH EUROPEAN CONFERENCE ON SOLID-STATE TRANSDUCERS (EUROSENSORS 2014)　87　612-615　2014

    DOI： 10.1016/j.proeng.2014.11.563 　

    ISSN： 1877-7058

  50. Device simulation of the light-addressable potentiometric sensor with a novel photoexcitation method for a higher spatial resolution Peer-reviewed

    Yuanyuan Guo, Kosuke Seki, Ko-ichiro Miyamoto, Torsten Wagner, Michael J. Schoening, Tatsuo Yoshinobu

    28TH EUROPEAN CONFERENCE ON SOLID-STATE TRANSDUCERS (EUROSENSORS 2014)　87　456-459　2014

    DOI： 10.1016/j.proeng.2014.11.369 　

    ISSN： 1877-7058

  51. Chemical imaging of the concentration profile of ion diffusion in a microfluidic channel Peer-reviewed

    Ko-ichiro Miyamoto, Hiroki Ichimura, Torsten Wagner, Michael J. Schoening, Tatsuo Yoshinobu

    SENSORS AND ACTUATORS B-CHEMICAL　189　240-245　2013/12

    DOI： 10.1016/j.snb.2013.04.057 　

    ISSN： 0925-4005

  52. Visualization of enzymatic reaction in a microfluidic channel using chemical imaging sensor Peer-reviewed

    Ko-ichiro Miyamoto, Yuji Hirayama, Torsten Wagner, Michael J. Schoening, Tatsuo Yoshinobu

    ELECTROCHIMICA ACTA　113　768-772　2013/12

    DOI： 10.1016/j.electacta.2013.08.089 　

    ISSN： 0013-4686

    eISSN： 1873-3859

  53. High-speed chemical imaging system based on front-side-illuminated LAPS Peer-reviewed

    Akinori Itabashi, Naoki Kosaka, Ko-ichiro Miyamoto, Torsten Wagner, Michael J. Schoening, Tatsuo Yoshinobu

    SENSORS AND ACTUATORS B-CHEMICAL　182　315-321　2013/06

    DOI： 10.1016/j.snb.2013.03.016 　

    ISSN： 0925-4005

  54. Frequency behaviour of light-addressable potentiometric sensors Peer-reviewed

    Carl Frederik Werner, Torsten Wagner, Tatsuo Yoshinobu, Michael Keusgen, Michael J. Schoening

    PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE　210　(5)　884-891　2013/05

    DOI： 10.1002/pssa.201200929 　

    ISSN： 1862-6300

  55. Semiconductor-based sensors for imaging of chemical processes

    C. Frederik Werner, Tatsuo Yoshinobu, Ko-Ichiro Miyamoto, Michael J. Schöning, Torsten Wagner

    Sensoren und Messsysteme 2014 - 17. ITG/GMA-Fachtagung　2013

    Publisher: VDE Verlag GmbH

  56. Extraction of High Gamma Band EEG During Hand Movements

    Kanoh Shin'ichiro, Scherer Reinhold, Miyamoto Ko-ichiro, Yoshinobu Tatsuo

    BME　51　R-286-R-286　2013

    Publisher: Japanese Society for Medical and Biological Engineering

    DOI： 10.11239/jsmbe.51.R-286 　

    ISSN： 1347-443X

  57. High-speed chemical imaging inside a microfluidic channel Peer-reviewed

    A. Itabashi, K. Miyamoto, T. Wagner, M. J. Schoning, T. Yoshinobu

    2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013　1731-1734　2013

    DOI： 10.1109/Transducers.2013.6627121 　

  58. High speed and high resolution chemical imaging based on a new type of OLED-LAPS set-up Peer-reviewed

    Carl Frederik Werner, Torsten Wagner, Ko-ichiro Miyamoto, Tatsuo Yoshinobu, Michael J. Schoening

    SENSORS AND ACTUATORS B-CHEMICAL　175　118-122　2012/12

    DOI： 10.1016/j.snb.2011.12.102 　

    ISSN： 0925-4005

  59. Development and characterisation of a compact light-addressable potentiometric sensor (LAPS) based on the digital light processing (DLP) technology for flexible chemical imaging Peer-reviewed

    Torsten Wagner, Carl Frederik Werner, Ko-ichiro Miyamoto, Michael J. Schoening, Tatsuo Yoshinobu

    SENSORS AND ACTUATORS B-CHEMICAL　170　34-39　2012/07

    DOI： 10.1016/j.snb.2010.12.003 　

    ISSN： 0925-4005

  60. Miniaturized chemical imaging sensor system using an OLED display panel Peer-reviewed

    Ko-ichiro Miyamoto, Kazumi Kaneko, Akira Matsuo, Torsten Wagner, Shin'ichiro Kanoh, Michael J. Schoening, Tatsuo Yoshinobu

    SENSORS AND ACTUATORS B-CHEMICAL　170　82-87　2012/07

    DOI： 10.1016/j.snb.2011.02.029 　

    ISSN： 0925-4005

  61. Nutrient concentration-sensitive microorganism-based biosensor Peer-reviewed

    Carl Frederik Werner, Simone Groebel, Christoph Krumbe, Torsten Wagner, Thorsten Selmer, Tatsuo Yoshinobu, Marcus E. M. Baumann, Michael Keusgen, Michael J. Schoening

    PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE　209　(5)　900-904　2012/05

    DOI： 10.1002/pssa.201100801 　

    ISSN： 1862-6300

  62. Biorobotic actuator with a muscle tissue driven by a photostimulation Peer-reviewed

    Masahiro Shimizu, Shintaro Yawata, Kota Miyasaka, Koichiro Miyamoto, Toshifumi Asano, Tatsuo Yoshinobu, Hiromu Yawo, Toshihiko Ogura, Akio Ishiguro

    Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)　7375　394-395　2012

    DOI： 10.1007/978-3-642-31525-1_58 　

    ISSN： 0302-9743 1611-3349

  63. Light-addressable potentiometric sensors and light-addressable electrodes as a combined sensor-and-manipulator microsystem with high flexibility Peer-reviewed

    T. Wagner, N. Shigiahara, K. Miyamoto, J. Suzurikawa, F. Finger, M. J. Schoening, T. Yoshinobu

    26TH EUROPEAN CONFERENCE ON SOLID-STATE TRANSDUCERS, EUROSENSOR 2012　47　890-893　2012

    DOI： 10.1016/j.proeng.2012.09.290 　

    ISSN： 1877-7058

  64. Chemical imaging of ion diffusion in a microfluidic channel Peer-reviewed

    K. Miyamoto, H. Ichimura, T. Wagner, T. Yoshinobu, M. J. Schoening

    26TH EUROPEAN CONFERENCE ON SOLID-STATE TRANSDUCERS, EUROSENSOR 2012　47　886-889　2012

    DOI： 10.1016/j.proeng.2012.09.289 　

    ISSN： 1877-7058

  65. Generation of Spatial Filters by ICA for Detecting Motor-related Oscillatory EEG Peer-reviewed

    Shin'ichiro Kanoh, Ko-ichiro Miyamoto, Tatsuo Yoshinobu

    2012 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　1703-1706　2012

    ISSN： 1557-170X

  66. Field-programmable gate array based controller for multi spot light-addressable potentiometric sensors with integrated signal correction mode Peer-reviewed

    Carl Frederik Werner, Sebastian Schusser, Heiko Spelthahn, Torsten Wagner, Tatsuo Yoshinobu, Michael J. Schoening

    ELECTROCHIMICA ACTA　56　(26)　9656-9660　2011/11

    DOI： 10.1016/j.electacta.2011.03.012 　

    ISSN： 0013-4686

  67. Constant-phase-mode operation of the light-addressable potentiometric sensor Peer-reviewed

    Ko-ichiro Miyamoto, Torsten Wagner, Shuhei Mimura, Shin'ichiro Kanoh, Tatsuo Yoshinobu, Michael J. Schoening

    SENSORS AND ACTUATORS B-CHEMICAL　154　(2)　119-123　2011/06

    DOI： 10.1016/j.snb.2010.01.004 　

    ISSN： 0925-4005

  68. A high-density multi-point LAPS set-up using a VCSEL array and FPGA control Peer-reviewed

    Torsten Wagner, Carl Frederik B. Werner, Ko-Ichiro Miyamoto, Michael J. Schoening, Tatsuo Yoshinobu

    SENSORS AND ACTUATORS B-CHEMICAL　154　(2)　124-128　2011/06

    DOI： 10.1016/j.snb.2010.03.009 　

    ISSN： 0925-4005

  69. Determination of the extracellular acidification of Escherichia coli by a light-addressable potentiometric sensor Peer-reviewed

    Carl Frederik Werner, Christoph Krumbe, Katharina Schumacher, Simone Groebel, Heiko Spelthahn, Michael Stellberg, Torsten Wagner, Tatsuo Yoshinobu, Thorsten Selmer, Michael Keusgen, Marcus E. M. Baumann, Michael J. Schoening

    PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE　208　(6)　1340-1344　2011/06

    DOI： 10.1002/pssa.201001141 　

    ISSN： 1862-6300

  70. Development of a Muscle Cell Actuator That Contracts by a Photostimulation

    八幡 慎太郎, 清水 正宏, 宮本 浩一郎, 宮坂 恒太, 浅野 豪文, 吉信 達夫, 八尾 寛, 小椋 利彦, 石黒 章夫

    日本機械学会ロボティクス・メカトロニクス講演会（ROBOMEC2011）予稿集　1A2-E01　2011/05

  71. Phase-mode LAPS and its application to chemical imaging Peer-reviewed

    Ko-ichiro Miyamoto, Torsten Wagner, Tatsuo Yoshinobu, Shin'ichiro Kanoh, Michael J. Schoening

    SENSORS AND ACTUATORS B-CHEMICAL　154　(1)　28-32　2011/05

    DOI： 10.1016/j.snb.2009.12.022 　

    ISSN： 0925-4005

  72. Positive Patterning of Ferritin and Fibronectin Molecules on Silicon by the Atomic Force Microscopic Anodic Oxidation Technique Peer-reviewed

    Kumaran Shanmugam, Tatsuo Yoshinobu, Wonchul Moon, Hiroshi Lwasaki

    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY　11　(5)　3808-3813　2011/05

    DOI： 10.1166/jnn.2011.4171 　

    ISSN： 1533-4880

  73. Differential Setup of Light-Addressable Potentiometric Sensor with an Enzyme Reactor in a Flow Channel Peer-reviewed

    Ko-ichiro Miyamoto, Midori Yoshida, Taito Sakai, Atsushi Matsuzaka, Torsten Wagner, Shin'ichiro Kanoh, Tatsuo Yoshinobu, Michael J. Schoening

    JAPANESE JOURNAL OF APPLIED PHYSICS　50　(4)　04DL08　2011/04

    DOI： 10.1143/JJAP.50.04DL08 　

    ISSN： 0021-4922

    eISSN： 1347-4065

  74. Phase-Mode Operation of FDM-LAPS Peer-reviewed

    Ko-ichiro Miyamoto, Torsten Wagner, Tatsuo Yoshinobu, Shin'ichiro Kanoh, Michael J. Schoening

    SENSOR LETTERS　9　(2)　691-694　2011/04

    DOI： 10.1166/sl.2011.1593 　

    ISSN： 1546-198X

    eISSN： 1546-1971

  75. Utilising Digital Micro-Mirror Device (DMD) as Scanning Light Source for Light-Addressable Potentiometric Sensors (LAPS) Peer-reviewed

    T. Wagner, K. Miyamoto, C. F. Werner, M. J. Schoening, T. Yoshinobu

    SENSOR LETTERS　9　(2)　812-815　2011/04

    DOI： 10.1166/sl.2011.1620 　

    ISSN： 1546-198X

    eISSN： 1546-1971

  76. Multi-well structure for cell culture on the chemical imaging sensor Peer-reviewed

    K. Miyamoto, T. Wagner, M. J. Schöning, T. Yoshinobu

    2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11　2130-2132　2011

    DOI： 10.1109/TRANSDUCERS.2011.5969264 　

  77. Flexible electrochemical imaging with "zoom-in" functionality by using a new type of light-addressable potentiometric sensor Peer-reviewed

    T. Wagner, K. Miyamoto, C. F. Werner, M. J. Schöning, T. Yoshinobu

    2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11　2133-2135　2011

    DOI： 10.1109/TRANSDUCERS.2011.5969294 　

  78. A P300-based BCI System for Controlling Computer Cursor Movement Peer-reviewed

    S. Kanoh, K. Miyamoto, T. Yoshinobu

    2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　6405-6408　2011

    ISSN： 1557-170X

  79. Monitoring the metabolic Activity of Microorganisms for Controlling the biological Process in the Biogas Fermenter Peer-reviewed

    C. Frederik Werner, Simone Groebel, Thorsten Selmer, Marcus M. E. Baumann, Michael J. Schoening, Torsten Wagner, Tatsuo Yoshinobu

    BIOGAS 2011: ENERGIETRAGER DER ZUKUNFT　2121　285-286　2011

    ISSN： 0083-5560

  80. Microfluidic systems with free definable sensor spots by an integrated light-addressable potentiometric sensor Peer-reviewed

    Torsten Wagner, Ko-ichiro Miyamoto, Noriko Shigihara, Michael J. Schoening, Tatsuo Yoshinobu

    EUROSENSORS XXV　25　2011

    DOI： 10.1016/j.proeng.2011.12.194 　

    ISSN： 1877-7058

  81. High speed and high resolution chemical imaging based on a new type of OLED-LAPS set-up Peer-reviewed

    Carl Frederik Werner, Torsten Wagner, Ko-ichiro Miyamoto, Tatsuo Yoshinobu, Michael J. Schoeninig

    EUROSENSORS XXV　25　118-122　2011

    DOI： 10.1016/j.proeng.2011.12.085 　

    ISSN： 1877-7058

  82. Self-organization of a Myofilament-actuator by Exploiting Mechanical Stimulus

    武田孟, 八幡慎太郎, 清水正宏, 宮本浩一郎, 宮坂恒太, 浅野豪文, 吉信達夫, 八尾寛, 小椋利彦, 石黒章夫

    計測自動制御学会SI部門講演会SI2010予稿集　777-780　2010/12

  83. Efficient Fabrication of a Myofilament-actuator by Exploiting Mechanical Stimulus

    武田孟, 八幡慎太郎, 清水正宏, 宮本浩一郎, 宮坂恒太, 浅野豪文, 吉信達夫, 八尾寛, 小椋利彦, 石黒章夫

    第28回日本ロボット学会学術講演会予稿集　AC2N2-2　2010/09

  84. xBCI: A Generic Platform for Development of an Online BCI System Peer-reviewed

    I. Putu Susila, Shin'ichiro Kanoh, Ko-ichiro Miyamoto, Tatsuo Yoshinobu

    IEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING　5　(4)　467-473　2010/07

    DOI： 10.1002/tee.20560 　

    ISSN： 1931-4973

    eISSN： 1931-4981

  85. Development of a Micro-actuator by Exploiting Mechanical Stimulus Response of Muscle Cells

    武田孟, 八幡慎太郎, 清水正宏, 宮本浩一郎, 宮坂恒太, 吉信達夫, 小椋利彦, 石黒章夫

    日本機械学会ロボティクス・メカトロニクス講演会（ROBOMEC2010）予稿集　2010　2P1-B11(1)-2P1-B11(4)　2010/06

    Publisher: The Japan Society of Mechanical Engineers

    More details Close

    Recently, robotic studies based on biological materials have been attracting a lot of attention, because of its intrinsic abilities. Biological materials have some interesting capabilities in such a way that tissues as devices can be self-organized, adaptable, self-repaired, and so on. Such significant abilities are based on cellular behavior that reflects mechanical stimuli during the development of the tissues. Under this circumstance, in this paper, we intend to deal with development of a micro-actuator by exploiting mechanical stimulus response of muscle cells. To do so, we carry out the induction of differentiation into myofilaments from a cultured myoblasts C2C12 under the periodic stretching forces for 70 hours. As a result, interestingly, we found that induction of differentiation into myofilament-like calls are promoted under the mechanical stimulus.

  86. FPGA-based LAPS device for the flexible design of sensing sites on functional interfaces Peer-reviewed

    Torsten Wagner, Carl Frederik Werner, Ko-ichiro Miyamoto, Hans-Josef Ackermann, Tatsuo Yoshinobu, Michael J. Schoening

    PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE　207　(4)　844-849　2010/04

    DOI： 10.1002/pssa.200983320 　

    ISSN： 1862-6300

    eISSN： 1862-6319

  87. Image correction method for the chemical imaging sensor Peer-reviewed

    Ko-ichiro Miyamoto, Yuri Sugawara, Shin'ichiro Kanoh, Tatsuo Yoshinobu, Torsten Wagner, Michael J. Schoening

    SENSORS AND ACTUATORS B-CHEMICAL　144　(2)　344-348　2010/02

    DOI： 10.1016/j.snb.2008.10.069 　

    ISSN： 0925-4005

  88. A brain-computer interface (BCI) system based on auditory stream segregation Peer-reviewed

    Shin'ichiro Kanoh, Ko-Ichiro Miyamoto, Tatsuo Yoshinobu

    Journal of Biomechanical Science and Engineering　5　(1)　32-40　2010

    DOI： 10.1299/jbse.5.32 　

    ISSN： 1880-9863

  89. Miniaturized chemical imaging sensor system using an OLED display panel

    Ko-ichiro Miyamoto, Kazumi Kaneko, Akira Matsuo, Torsten Wagner, Shin'ichiro Kanoh, Michael J. Schoening, Tatsuo Yoshinobu

    EUROSENSORS XXIV CONFERENCE　5　516-519　2010

    DOI： 10.1016/j.proeng.2010.09.160 　

    ISSN： 1877-7058

  90. Novel combination of digital light processing (DLP) and light-addressable potentiometric sensors (LAPS) for flexible chemical imaging

    Torsten Wagner, Ko-ichiro Miyamoto, Michael J. Schoening, Tatsuo Yoshinobu

    EUROSENSORS XXIV CONFERENCE　5　520-523　2010

    DOI： 10.1016/j.proeng.2010.09.161 　

    ISSN： 1877-7058

  91. Characteristics of Short-Term Sequence Memory of Tone Durations Peer-reviewed

    S. Kanoh, R. Futami, T. Yoshinobu, N. Hoshimiya

    Transactions of Japanese Society for Medical and Biological Engineering　47　(6)　566-573　2009/12

    Publisher: Japanese Society for Medical and Biological Engineering

    DOI： 10.11239/jsmbe.47.566 　

    ISSN： 1347-443X

    More details Close

    The mechanism to encode and store the information on time is essential to uncover the nature of temporal information processing in the sensory, memory and higher-order areas in the brain. In this article, the results of psychophysical experiments on short-term memory of tone durations in auditory sequence were reported. Subjects were requested to recall the durations of all the tones presented serially (sequence) by a telegraph key. The performance of recall was evaluated by correlation coefficients and the distribution in correlation diagram between presented and recalled tone durations, and the relationship to the serial order and the number of tones in a presented sequence were investigated. It was shown that the performance of the recall of tone durations could be evaluated by cross-correlation, and the performance decreased when the serial order of the target tone in the presented sequence was later or the number of tones in a sequence was larger. It was also shown that there were some types of characteristic distribution on the correlation diagram between presented and recalled tone durations which corresponded to the degree of memory decay. This result indicated that the behavioral process of memory decay of the analogue (non-categorized) information could be observed by the profile of correlation diagram.

  92. Chemical image scanner based on FDM-LAPS Peer-reviewed

    K. Miyamoto, Yohei Kuwabara, Shin'ichiro Kanoh, Tatsuo Yoshinobu, Torsten Wagner, Michael J. Schoening

    SENSORS AND ACTUATORS B-CHEMICAL　137　(2)　533-538　2009/04

    DOI： 10.1016/j.snb.2008.12.008 　

    ISSN： 0925-4005

  93. Visualization of Ion Distribution by a Chemical Imaging Sensor

    Tatsuo Yoshinobu

    Nano-Biomedical Engineering 2009 (Imperial College Press)　2009/03/31

  94. Phase-mode LAPS and its application to chemical imaging Peer-reviewed

    K. Miyamoto, T. Wagner, T. Yoshinobu, S. Kanoh, M. J. Schöning

    TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems　1842-1845　2009

    DOI： 10.1109/SENSOR.2009.5285704 　

  95. Development of Brain-Computer Interface (BCI) System for Bridging Brain and Computer Peer-reviewed

    S. Kanoh, K. Miyamoto, T. Yoshinobu

    13TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, VOLS 1-3　23　(1-3)　2264-2267　2009

    ISSN： 1680-0737

  96. A NIRS-based Brain-Computer Interface System during Motor Imagery: System Development and Online Feedback Training Peer-reviewed

    Shin'ichiro Kanoh, Yu-mi Murayama, Ko-ichiro Miyamoto, Tatsuo Yoshinobu, Ryuta Kawashima

    2009 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-20　594-+　2009

    DOI： 10.1109/IEMBS.2009.5333710 　

    ISSN： 1557-170X

  97. A high-density multi-point LAPS set-up using a VCSEL array and FPGA control

    T. Wagner, C. F. Werner, K. Miyamoto, M. J. Schoening, T. Yoshinobu

    PROCEEDINGS OF THE EUROSENSORS XXIII CONFERENCE　1　(1)　1483-+　2009

    DOI： 10.1016/j.proche.2009.07.370 　

    ISSN： 1876-6196

  98. Constant-phase-mode operation of the light-addressable potentiometric sensor

    Ko-ichiro Miyamoto, Torsten Wagner, Shuhei Mimura, Shin'ichiro Kanoh, Tatsuo Yoshinobu, Michael J. Schoening

    PROCEEDINGS OF THE EUROSENSORS XXIII CONFERENCE　1　(1)　1487-+　2009

    DOI： 10.1016/j.proche.2009.07.371 　

    ISSN： 1876-6196

  99. Method of menu selection by gaze movement using AC EOG signals Peer-reviewed

    ShiN'Ichiro Kanoh, Ryoko Futami, Tatsuo Yoshinobu, Nozomu Hoshimiya

    IEEJ Transactions on Electronics, Information and Systems　129　(10)　1822-1827　2009

    Publisher: Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejeiss.129.1822 　

    ISSN： 1348-8155 0385-4221

  100. Investigation of methods for extracting features related to motor imagery and resting states in EEG-based BCI system Peer-reviewed

    I Putu Susila, Shin'Ichiro Kanoh, Ko-Ichiro Miyamoto, Tatsuo Yoshinobu

    IEEJ Transactions on Electronics, Information and Systems　129　(10)　1828-1833　2009

    Publisher: Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejeiss.129.1828 　

    ISSN： 1348-8155 0385-4221

  101. Visualization of Ion Distribution by Chemical Imaging Sensor

    Tatsuo YOSHINOBU

    MATERIALS INTEGRATION　21　(5)　225-231　2008/05

    Publisher:

    ISSN： 1344-7858

  102. A Brain-Computer Interface (BCI) System Based on Auditory Stream Segregation Peer-reviewed

    Shin'ichiro Kanoh, Ko-ichiro Miyamoto, Tatsuo Yoshinobu

    2008 30TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-8　642-645　2008

    DOI： 10.1109/IEMBS.2008.4649234 　

    ISSN： 1557-170X

  103. Handheld multi-channel LAPS device as a transducer platform for possible biological and chemical multi-sensor applications Peer-reviewed

    Torsten Wagner, Roberto Molina, Tatsuo Yoshinobu, Joachim P. Kloock, Manfi-Ed Biselli, Michelangelo Canzoneri, Thomas Schnitzler, Michael J. Schooning

    ELECTROCHIMICA ACTA　53　(2)　305-311　2007/12

    DOI： 10.1016/j.electacta.2007.04.006 　

    ISSN： 0013-4686

  104. A Semiconductor-Based Field-Effect Platform for (Bio-)Chemical and Physical Sensors: From Capacitive EIS Sensors and LAPS over ISFETs to Nano-scale Devices Peer-reviewed

    M. J. Sch?ning, M. H. Abouzar, T. Wagner, N. N?ther, D. Rolka, T. Yoshinobu, J. P. Kloock, M. Turek, S. Ingebrandt, A. Poghossian

    Mater. Res. Soc. Symp. Proc.　952E　0952-F08-02　2007/02

  105. Application of thin-film amorphous silicon to chemical imaging Invited Peer-reviewed

    Tatsuo Yoshinobu, Werner Moritz, Friedhelm Finger, Michael J. Schoening

    Amorphous and Polycrystalline Thin-Film Silicon Science and Technology 2006　910　481-490　2007

    ISSN： 0272-9172

  106. "All-in-one" solid-state device based on a light-addressable potentiometric sensor platform Peer-reviewed

    Torsten Wagner, Tatsuo Yoshinobu, Chanwen Rao, Ralph Otto, Michael J. Schoening

    SENSORS AND ACTUATORS B-CHEMICAL　117　(2)　472-479　2006/10

    DOI： 10.1016/j.snb.2005.12.056 　

    ISSN： 0925-4005

  107. PLD-prepared cadmium sensors based on chalcogenide glasses- ISFET, LAPS and mu ISE semiconductor structures Peer-reviewed

    J. P. Kloock, L. Moreno, A. Bratov, S. Huachupoma, J. Xu, T. Wagner, T. Yoshinobu, Y. Ermolenko, Y. G. Vlasov, M. J. Schoening

    SENSORS AND ACTUATORS B-CHEMICAL　118　(1-2)　149-155　2006/10

    DOI： 10.1016/j.snb.2006.04.018 　

    ISSN： 0925-4005

  108. "LAPS Card" - A novel chip card-based light-addressable potentiometric sensor (LAPS) Peer-reviewed

    T. Wagner, C. Rao, J. P. Kloock, T. Yoshinobu, R. Otto, M. Keusgen, M. J. Schoening

    SENSORS AND ACTUATORS B-CHEMICAL　118　(1-2)　33-40　2006/10

    DOI： 10.1016/j.snb.2006.04.019 　

    ISSN： 0925-4005

  109. Molecular fluorescence from H2TBP porphyrin film on Ag substrate excited by tunneling electrons Peer-reviewed

    Hongwen Liu, Ryusuke Nishitani, Yutaka Ie, Koichi Sudoh, Marek Nowicki, Tatsuo Yoshinobu, Yoshio Aso, Hiroshi Wasaki

    ULTRAMICROSCOPY　106　(8-9)　785-788　2006/06

    DOI： 10.1016/j.ultramic.2006.01.011 　

    ISSN： 0304-3991

  110. Micropatterning of Si surface with protein molecules by the AFM anodic oxidation method Invited Peer-reviewed

    J Suzuki, T Yoshinobu, W Moon, K Shanmugam, H Iwasaki

    ELECTROCHEMISTRY　74　(2)　131-134　2006/02

    DOI： 10.5796/electrochemistry.74.131 　

    ISSN： 1344-3542

  111. Plasmon-enhanced molecular fluorescence from an organic film in a tunnel junction Peer-reviewed

    HW Liu, Y Le, T Yoshinobu, Y Aso, H Iwasaki, R Nishitani

    APPLIED PHYSICS LETTERS　88　(6)　061901　2006/02

    DOI： 10.1063/1.2171795 　

    ISSN： 0003-6951

  112. The light-addressable potentiometric sensor for multi-ion sensing and imaging Invited Peer-reviewed

    T Yoshinobu, H Iwasaki, Y Ui, K Furuichi, Y Ermolenko, Y Mourzina, T Wagner, N Nather, MJ Schoning

    METHODS　37　(1)　94-102　2005/09

    DOI： 10.1016/j.ymeth.2005.05.020 　

    ISSN： 1046-2023

  113. Development of a handheld 16 channel pen-type LAPS for electrochemical sensing Peer-reviewed

    MJ Schoning, T Wagner, C Wang, R Otto, T Yoshinobu

    SENSORS AND ACTUATORS B-CHEMICAL　108　(1-2)　808-814　2005/07

    DOI： 10.1016/j.snb.2005.01.055 　

    ISSN： 0925-4005

  114. "All-in-one" solid-state device based on a light-addressable potentiometric sensor platform Peer-reviewed

    T Wagner, T Yoshinobu, R Otto, MJ Schoning

    Transducers '05, Digest of Technical Papers, Vols 1 and 2　1872-1875　2005

  115. Scanning tunneling microscope (STM)-excited molecular fluorescence from porphyrin thin films Peer-reviewed

    HW Liu, R Nishitani, Y Ie, T Yoshinobu, Y Aso, H Iwasaki

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS & EXPRESS LETTERS　44　(16-19)　L566-L569　2005

    DOI： 10.1143/JJAP.44.L566 　

    ISSN： 0021-4922

  116. Fabrication of thin-film LAPS with amorphous silicon Peer-reviewed

    T Yoshinobu, MJ Schoning, F Finger, W Moritz, H Iwasaki

    SENSORS　4　(10)　163-169　2004/10

    ISSN： 1424-8220

  117. A Handheld 16 Channel Pen-Type LAPS as a Platform for (Bio-)Electrochemical Sensing

    T. Wagner, M. J. Sch?ning, R. Otto and, T. Yoshinobu

    Biomedical Engineering　49　(Supplement 2)　996-997　2004/09

    DOI： 10.1016/j.snb.2005.01.055 　

  118. Potentiometric Imaging in a Microfluidic Channel

    T. Yoshinobu, Y. Ui, H. Iwasaki, N. N?ther, M. Koudelka-Hep, M. J. Sch?ning

    Biomedical Engineering　49　(Supplement 2)　998-999　2004/09

  119. Microscopy of Impedance and Surface Ion Concentrations

    W. Moritz, T. Yoshinobu, F. Finger, S. Krause, M. Xu, M. J. Sch?ning

    Biomedical Engineering　49　(Supplement 2)　1000-1002　2004/09

  120. Micropatterning of Biomolecules on Silicon by AFM Anodic Oxidation

    T. Yoshinobu, W. Moon, A. Nishikawa, J. Suzuki, H. Iwasaki

    Biomedical Engineering　49　(Supplement 2)　1038-1039　2004/09

  121. Laser-scanned silicon transducer (LSST) as a multisensor system Peer-reviewed

    YE Ermolenko, T Yoshinobu, YG Mourzina, YG Vlasov, MJ Schoning, H Iwasaki

    SENSORS AND ACTUATORS B-CHEMICAL　103　(1-2)　457-462　2004/09

    DOI： 10.1016/j.snb.2004.05.005 　

    ISSN： 0925-4005

  122. High resolution LAPS using amorphous silicon as the semiconductor material Peer-reviewed

    W Moritz, T Yoshinobu, F Finger, S Krause, M Martin-Fernandez, MJ Schoning

    SENSORS AND ACTUATORS B-CHEMICAL　103　(1-2)　436-441　2004/09

    DOI： 10.1016/j.snb.2004.04.073 　

    ISSN： 0925-4005

  123. Development of a Handheld 16 Channel Pen-Type LAPS for Electrochemical Sensing

    M. J. Sch?ning, C. Wang, R. Otto, T. Yoshinobu

    Chemical Sensors (Technical Digest of The 10th International Meeting on Chemical Sensors)　20　(Supplement B)　136-137　2004/07

  124. AFM Patterning and Immobilization of Biomolecules on Si

    W.-C. Moon, T. Yoshinobu, A. Nishikawa, H. Iwasaki

    Chemical Sensors (Technical Digest of The 10th International Meeting on Chemical Sensors)　20　(Supplement B)　772-773　2004/07

  125. Immobilization of Urease and Cholinesterase on the Surface of Semiconductor Transducer for the Development of Light-Addressable Potentiometric Sensors

    I. G. Mourzina, T. Yoshinobu, Yu. E. Ermolenko, Yu. G. Vlasov, M. J. Sch?ning, H. Iwasaki

    Chemical Sensors (Technical Digest of The 10th International Meeting on Chemical Sensors)　20　(Supplement B)　788-789　2004/07

  126. Patterning of biomolecules on silicon by AFM oxidation

    T. Yoshinobu, W. C. Moon, A. Nishikawa, J. Suzuki, H. Iwasaki

    Digest of Papers - Microprocesses and Nanotechnology 2004　336-337　2004

  127. Fabrication of thin-film LAPS with amorphous silicon

    Tatsuo Yoshinobu, Michael J. Schöning, Friedhelm Finger, Werner Moritz, Hiroshi Iwasaki

    Sensors　4　(10)　163-169　2004

    Publisher: MDPI AG

    DOI： 10.3390/s41000163 　

    ISSN： 1424-3210

  128. Immobilization of urease and cholinesterase on the surface of semiconductor transducer for the development of light-addressable potentiometric sensors Peer-reviewed

    IG Mourzina, T Yoshinobu, YE Ermolenko, YG Vlasov, MJ Schoning, H Iwasaki

    MICROCHIMICA ACTA　144　(1-3)　41-50　2004/01

    DOI： 10.1007/s00604-003-0091-4 　

    ISSN： 0026-3672

  129. Application of AFM anodic oxidation to patterning of biomolecules on Si Peer-reviewed

    T Yoshinobu, W Moon, A Nishikawa, J Suzuki, H Iwasaki

    SENSORS AND MATERIALS　16　(8)　421-428　2004

    ISSN： 0914-4935

  130. Detection of protein-protein interactions onSiO(2)/Si surfaces by spectroscopic ellipsometry Peer-reviewed

    S Kodera, T Okajima, H Iwabuki, D Kitaguchi, S Kuroda, T Yoshinobu, K Tanizawa, M Futai, H Iwasaki

    ANALYTICAL BIOCHEMISTRY　321　(1)　65-70　2003/10

    DOI： 10.1016/S0003-2697(03)00422-6 　

    ISSN： 0003-2697

  131. Portable light-addressable potentiometric sensor (LAPS) for multisensor applications Peer-reviewed

    T Yoshinobu, MJ Schoning, R Otto, K Furuichi, Y Mourizina, Y Ermolenko, H Iwasaki

    SENSORS AND ACTUATORS B-CHEMICAL　95　(1-3)　352-356　2003/10

    DOI： 10.1016/S0925-4005(03)00437-4 　

    ISSN： 0925-4005

  132. Investigation on light-addressable potentiometric sensor as a possible cell-semiconductor hybrid Peer-reviewed

    ABM Ismail, T Yoshinobu, H Iwasaki, H Sugihara, T Yukimasa, Hirata, I, H Iwata

    BIOSENSORS & BIOELECTRONICS　18　(12)　1509-1514　2003/10

    DOI： 10.1016/S0956-5663(03)00129-5 　

    ISSN： 0956-5663

  133. K+-selective field-effect sensors as transducers for bioelectronic Peer-reviewed

    Y Mourzina, T Mai, A Poghossian, Y Ermolenko, T Yoshinobu, Y Vlasov, H Iwasaki, MJ Schoning

    ELECTROCHIMICA ACTA　48　(20-22)　3333-3339　2003/09

    DOI： 10.1016/S0013-4686(03)000402-X 　

    ISSN： 0013-4686

  134. AFM fabrication of oxide patterns and immobilization of biomolecules on Si surface Peer-reviewed

    T Yoshinobu, J Suzuki, H Kurooka, WC Moon, H Iwasaki

    ELECTROCHIMICA ACTA　48　(20-22)　3131-3135　2003/09

    DOI： 10.1016/S0013-4686(03)00342-6 　

    ISSN： 0013-4686

  135. Flow-velocity microsensors based on semiconductor field-effect structures Peer-reviewed

    A Poghossian, T Yoshinobu, MJ Schoning

    SENSORS　3　(7)　202-212　2003/07

    ISSN： 1424-8220

  136. Anion-selective light-addressable potentiometric sensors (LAPS) for the determination of nitrate and sulphate ions Peer-reviewed

    YG Mourzina, YE Ermolenko, T Yoshinobu, Y Vlasov, H Iwasaki, MJ Schoning

    SENSORS AND ACTUATORS B-CHEMICAL　91　(1-3)　32-38　2003/06

    DOI： 10.1016/S0925-4005(03)00063-7 　

    ISSN： 0925-4005

  137. Multi-Component Analysis Based on the Light-Addressable Potentiometric Sensor (LAPS)

    T. Yoshinobu, Y. Ermolenko, Y. Mourzina, M. J. Sch?ning, H. Iwasaki, Y. Vlasov

    SENSOR 2003 Proceedings　141-144　2003/05

    DOI： 10.1016/S0925-4005(03)00437-4 　

  138. The double K+/Ca2+ sensor based on laser scanned silicon transducer (LSST) for multi-component analysis Peer-reviewed

    Y Ermolenko, T Yoshinobu, Y Mourzina, K Furuichi, S Levichev, MJ Schoning, Y Vlasov, H Iwasaki

    TALANTA　59　(4)　785-795　2003/03

    DOI： 10.1016/S0039-9140(02)00620-3 　

    ISSN： 0039-9140

  139. Flow-velocity microsensors based on semiconductor field-effect structures

    Arshak Poghossian, Tatsuo Yoshinobu, Michael J. Schöning

    Sensors　3　(7)　202-212　2003

    Publisher: MDPI AG

    DOI： 10.3390/s30700202 　

    ISSN： 1424-3210

  140. Investigation on LaF3 material in a simple structure of Si/LaF3 as a possible light-addressable potentiometric fluoride (F-) sensor. Peer-reviewed

    AB Ismail, K Furuichi, T Yoshinobu, H Iwasaki

    ICEMI'2003: PROCEEDINGS OF THE SIXTH INTERNATIONAL CONFERENCE ON ELECTRONIC MEASUREMENT & INSTRUMENTS, VOLS 1-3　819-822　2003

  141. Patterned surface as a template for DNA-based nanotechnology

    WC Moon, A Nishikawa, T Yoshinobu, H Iwasaki

    CEC: 2003 CONGRESS ON EVOLUTIONARY COMPUTATION, VOLS 1-4, PROCEEDINGS　2727-2732　2003

    DOI： 10.1109/CEC.2003.1299433 　

  142. Light-addressable potentiometric fluoride (F-) sensor Peer-reviewed

    AM Ismail, K Furuichi, T Yoshinobu, H Iwasaki

    SENSORS AND ACTUATORS B-CHEMICAL　86　(1)　94-97　2002/08

    DOI： 10.1016/S0925-4005(02)00153-3 　

    ISSN： 0925-4005

  143. Enhanced nano-oxidation on a SCl-treated Si surface using atomic force microscopy Peer-reviewed

    WC Moon, T Yoshinobu, H Iwasaki

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS　41　(7A)　4754-4757　2002/07

    DOI： 10.1143/JJAP.41.4754 　

    ISSN： 0021-4922

  144. Photocurable membranes for ion-selective light-addressable potentiometric sensor Peer-reviewed

    Y Ermolenko, T Yoshinobu, Y Mourzina, S Levichev, K Furuichi, Y Vlasov, MJ Schoning, H Iwasaki

    SENSORS AND ACTUATORS B-CHEMICAL　85　(1-2)　79-85　2002/06

    DOI： 10.1016/S0925-4005(02)00056-4 　

    ISSN： 0925-4005

  145. Lithium sensor based on the laser scanning semiconductor transducer Peer-reviewed

    Y Ermolenko, T Yoshinobu, Y Mourzina, K Furuichi, S Levichev, Y Vlasov, MJ Schoning, H Iwasaki

    ANALYTICA CHIMICA ACTA　459　(1)　1-9　2002/05

    DOI： 10.1016/S0003-2670(02)00102-2 　

    ISSN： 0003-2670

  146. Chalcogenide Glass Sensors for the Heavy Metal Analysis

    J. P. Klook, Yu. Mourzina, T. Yoshinobu, J. Schubert, M. J. Sch?ning

    Sensors and Measurement System 2002　397-400　2002/03

  147. Innovative Film Technologies and Measurement Principles for Capacitive Field Effect Sensors

    M. J. Sch?ning, T. Yoshinobu, J. Schubert, A. Steffen, H. L?th

    Sensors and Measurement System 2002　151-154　2002/03

  148. Technology of Photocurable Polymeric Membranes for the Integrated LAPS

    Yu. Ermolenko, T. Yoshinobu, Yu. Mourzina, K. Furuichi, H. Iwasaki, Yu. Vlasov, M. J. Sch?ning

    Chemical Sensors (Proceedings of The 5th East Asian Conference on Chemical Sensors / The 33rd Chemical Sensor Symposium)　17　(Supplement B)　66-68　2001/12

  149. Simultaneous Visualization of Multiple Ions by the Chemical Imaging Sensor

    K. Furuichi, T. Yoshinobu, Yu. Ermolenko, Yu. Mourzina, H. Iwasaki, M. J. Sch?ning

    Chemical Sensors (Proceedings of The 5th East Asian Conference on Chemical Sensors / The 33rd Chemical Sensor Symposium)　17　(Supplement B)　399-401　2001/12

  150. The Hybrid K+/Ca2+ Sensor Based on Laser Scanned Silicon Transducer for Multi-Component Analysis Peer-reviewed

    Yu. Ermolenko, T. Yoshinobu, Yu. Mourzina, M. J. Schoening, Yu. Vlasov, H. Iwasaki

    Analytical Sciences　17　(Suppl.)　i777-i780　2001/12

  151. シリコン表面のナノトライボロジー Peer-reviewed

    W. C. Moon, T. Yoshinobu, H. Iwasaki

    J. Surf. Sci. Soc. Jpn.　22　(12)　805-810　2001/12

    Publisher: The Surface Science Society of Japan

    DOI： 10.1380/jsssj.22.805 　

    ISSN： 0388-5321

    More details Close

    Atomic force microscopy (AFM) has been used for nanotribological studies of silicon surfaces covered by oxide layers of various kinds: chemical oxides prepared by SC 1 (NH4OH/H2O2/H2O) and SC 2 (HCl/H2O2/H2O) treatments, a thermally treated silicon surface and a H-terminated oxide-free silicon surface. Only in the case of SC 1 chemical oxide, scratching of the oxide and ploughing of the silicon by a Si3N4 AFM tip were observed. On the other hand, no wear of the sample was noted on other surfaces. By annealing the SC 1-treated surface in N2 gas above 200oC for 30 min, the oxide layer could not be scratched. By soaking the thermal oxide in KOH, the oxide layer was then scratched. It is suggested that the presence of OH bases is a requirement for the nano-scratching of the oxide layers.

  152. Induction of chemical waves by mechanical stimulation in elastic Belousov-Zhabotinsky media Peer-reviewed

    K Suzuki, T Yoshinobu, H Iwasaki

    CHEMICAL PHYSICS LETTERS　349　(5-6)　437-441　2001/12

    DOI： 10.1016/S0009-2614(01)01243-X 　

    ISSN： 0009-2614

  153. Ion-selective light-addressable potentiometric sensor (LAPS) with chalcogenide thin film prepared by pulsed laser deposition Peer-reviewed

    Y Mourzina, T Yoshinobu, J Schubert, H Luth, H Iwasaki, MJ Schoning

    SENSORS AND ACTUATORS B-CHEMICAL　80　(2)　136-140　2001/11

    DOI： 10.1016/S0925-4005(01)00906-6 　

    ISSN： 0925-4005

  154. Chemical imaging sensor and its application to biological systems Peer-reviewed

    T Yoshinobu, H Ecken, ABM Ismail, H Iwasaki, H Luth, MJ Schoning

    ELECTROCHIMICA ACTA　47　(1-2)　259-263　2001/09

    DOI： 10.1016/S0013-4686(01)00564-3 　

    ISSN： 0013-4686

  155. Penicillin detection by means of field-effect based sensors: EnFET, capacitive EIS sensor or LAPS? Peer-reviewed

    A Poghossian, T Yoshinobu, A Simonis, H Ecken, H Luth, MJ Schoning

    SENSORS AND ACTUATORS B-CHEMICAL　78　(1-3)　237-242　2001/08

    DOI： 10.1016/S0925-4005(01)00819-X 　

    ISSN： 0925-4005

  156. Bioelectronic Signal Processing - Intact Chemoreceptors Coupled to Field-Effect Devices Peer-reviewed

    P. Schroth, B. Weissbecker, S. Schutz, H. Ecken, T. Yoshinobu, H. Lueth, M. J. Schoening

    Biocybernetics and Biomedical Engineering　21　(3)　27-42　2001/06

  157. Alternative sensor materials for light-addressable potentiometric sensors Peer-reviewed

    T Yoshinobu, H Ecken, A Poghossian, H Luth, H Iwasaki, MJ Schoning

    SENSORS AND ACTUATORS B-CHEMICAL　76　(1-3)　388-392　2001/06

    DOI： 10.1016/S0925-4005(01)00646-3 　

    ISSN： 0925-4005

  158. Constant-current-mode LAPS (CLAPS) for the detection of penicillin Peer-reviewed

    T Yoshinobu, H Ecken, A Poghossian, A Simonis, H Iwasaki, H Luth, MJ Schoning

    ELECTROANALYSIS　13　(8-9)　733-736　2001/05

    DOI： 10.1002/1521-4109(200105)13:8/9<733::AID-ELAN733>3.0.CO;2-N 　

    ISSN： 1040-0397

  159. A novel low-noise measurement principle for LAPS and its application to faster measurement of pH Peer-reviewed

    ABM Ismail, H Sugihara, T Yoshinobu, H Iwasaki

    SENSORS AND ACTUATORS B-CHEMICAL　74　(1-3)　112-116　2001/04

    DOI： 10.1016/S0925-4005(00)00719-X 　

    ISSN： 0925-4005

  160. An Organic Film/SiO2/Si Heterostructure as a Novel Biological Interface of a Light-Addressable Potentiometric Sensor Peer-reviewed

    A. B, Md. Ismail, T. Yoshinobu, H. Iwasaki

    Trans. IEE of Japan　121E　(2)　94-99　2001/02

    Publisher: The Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejsmas.121.94 　

    ISSN： 1341-8939

    More details Close

    A light-addressable potentiometric sensor (LAPS) with Poly-L-Omithine with Laminin (PLOL)-coated SiO2 layer as the only insulating material on the bulk Si in SiO2/Si structure, is investigated as a possible biological interface. Comparing with the conventional structure (Si3N4/SiO2/Si) of the LAPS, much steeper photocurrent response was observed for the PLOL-coated SiO2/Si structure, which shows higher surface potential sensitivity and pH resolution. PLOL-coated SiO2 layer is kept soaked with the electrolyte for ten days and no appreciable change in the surface potential sensitivity was noticed. The pH sensitivity of the sensor was investigated in the pH range of pH4 to pH10, and a nearly Nernstian sensitivity was observed.

  161. Improvement of sensitivity of the light-addressable potentiometric sensors for the purpose of noninvasive measurement of electrical activity of biological cells Peer-reviewed

    ABM Ismail, H Sugihara, T Yukimasa, T Yoshinobu, H Iwasaki

    SICON/01: ISA/IEEE SENSORS FOR INDUSTRY CONFERENCE, PROCEEDINGS　215-218　2001

  162. Atomic surface characterisation and modification of the layered compounds Bi2Se3, Bi1.9Sb0.1Se3 and Bi1.6Sb0.4Se3 Peer-reviewed

    SA Contera, T Yoshinobu, H Iwasaki, Z Bastl, P Lostak

    ULTRAMICROSCOPY　86　(1-2)　55-61　2001/01

    DOI： 10.1016/S0304-3991(00)00088-7 　

    ISSN： 0304-3991

  163. Nanotribology of Si oxide layers on Si by atomic force microscopy Peer-reviewed

    WC Moon, T Yoshinobu, H Iwasaki

    ULTRAMICROSCOPY　86　(1-2)　49-53　2001/01

    DOI： 10.1016/S0304-3991(00)00089-9 　

    ISSN： 0304-3991

  164. Semiconductor-based field-effect structures for chemical sensing Peer-reviewed

    MJ Schoning, A Poghossian, T Yoshinobu, H Luth

    ADVANCED ENVIRONMENTAL AND CHEMICAL SENSING TECHNOLOGY　4205　188-198　2001

    DOI： 10.1117/12.417449 　

    ISSN： 0277-786X

  165. Investigation of pulsed laser-deposited Al2O3 as a high pH-sensitive layer for LAPS-based biosensing applications Peer-reviewed

    AM Ismail, T Harada, T Yoshinobu, H Iwasaki, MJ Schoning, H Luth

    SENSORS AND ACTUATORS B-CHEMICAL　71　(3)　169-172　2000/12

    DOI： 10.1016/S0925-4005(99)00380-9 　

    ISSN： 0925-4005

  166. Comparative study of chemical waves and temporal oscillations in the Ru(bpy)(3)(2+)-catalyzed photosensitive Belousov-Zhabotinsky reaction Peer-reviewed

    T Akagi, N Okazaki, T Yoshinobu, T Matsumura-Inoue

    CHEMICAL PHYSICS LETTERS　328　(1-2)　214-220　2000/09

    ISSN： 0009-2614

  167. Unidirectional propagation of chemical waves through microgaps between zones with different excitability Peer-reviewed

    K Suzuki, T Yoshinobu, H Iwasaki

    JOURNAL OF PHYSICAL CHEMISTRY A　104　(28)　6602-6608　2000/07

    DOI： 10.1021/jp0007078 　

    ISSN： 1089-5639

  168. Diffusive propagation of chemical waves through a microgap Peer-reviewed

    K Suzuki, T Yoshinobu, H Iwasaki

    JOURNAL OF PHYSICAL CHEMISTRY A　104　(21)　5154-5159　2000/06

    DOI： 10.1021/jp000009n 　

    ISSN： 1089-5639

  169. Application of the pH-imaging sensor to determining the diffusion coefficients of ions in electrolytic solutions Peer-reviewed

    T Yoshinobu, T Harada, H Iwasaki

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS　39　(4A)　L318-L320　2000/04

    DOI： 10.1143/JJAP.39.L318 　

    ISSN： 0021-4922

  170. Current-induced step bunching on vicinal Si(111) studied by light scattering Peer-reviewed

    T Yoshinobu, S Matsukawa, K Sudoh, H Iwasaki

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS　39　(4B)　L380-L383　2000/04

    DOI： 10.1143/jjap.39.L380 　

    ISSN： 0021-4922

  171. Formation of nano-pyramids of layered materials with AFM Peer-reviewed

    SA Contera, T Yoshinobu, H Iwasaki, Z Bastl, P Lostak

    ULTRAMICROSCOPY　82　(1-4)　165-170　2000/02

    DOI： 10.1016/S0304-3991(99)00128-X 　

    ISSN： 0304-3991

  172. Lift-off patterning of thin Au films on Si surfaces with atomic force microscopy Peer-reviewed

    W Moon, T Yoshinobu, H Iwasaki

    ULTRAMICROSCOPY　82　(1-4)　119-123　2000/02

    DOI： 10.1016/S0304-3991(99)00130-8 　

    ISSN： 0304-3991

  173. Scanning tunneling microscopy nanofabrication of electronic industry compatible thermal Si oxide Peer-reviewed

    N Li, T Yoshinobu, H Iwasaki

    ULTRAMICROSCOPY　82　(1-4)　97-101　2000/02

    DOI： 10.1016/S0304-3991(99)00129-1 　

    ISSN： 0304-3991

  174. Nanotribology of clean and oxide-covered silicon surfaces using atomic force microscopy Peer-reviewed

    W Moon, SA Contera, T Yoshinobu, H Iwasaki

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS　39　(1)　272-274　2000/01

    DOI： 10.1143/JJAP.39.272 　

    ISSN： 0021-4922

  175. Nanoscale patterning of Au films on Si surfaces by atomic force microscopy Peer-reviewed

    WC Moon, T Yoshinobu, H Iwasaki

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS　38　(12A)　6952-6954　1999/12

    DOI： 10.1143/JJAP.38.6952 　

    ISSN： 0021-4922

  176. Mesoscopic scanning tunneling and atomic force microscopy study of the misfit-layer compounds (LaSe)(x)NbSe2 and (PbSe)(x)NbSe2 Peer-reviewed

    SA Contera, T Yoshinobu, H Iwasaki, K Kisoda

    SURFACE SCIENCE　441　(2-3)　384-390　1999/11

    DOI： 10.1016/S0039-6028(99)00858-4 　

    ISSN： 0039-6028

  177. Application of the chemical imaging sensor to electrophysiological measurement of a neural cell Peer-reviewed

    Hiroshi Tanaka, Tatsuo Yoshinobu, Hiroshi Iwasaki

    Sensors and Actuators, B: Chemical　59　(1)　21-25　1999/10/05

    Publisher: Elsevier Sequoia SA

    DOI： 10.1016/S0925-4005(99)00012-X 　

    ISSN： 0925-4005

  178. Ligation errors in DNA computing Peer-reviewed

    Y Aoi, T Yoshinobu, K Tanizawa, K Kinoshita, H Iwasaki

    BIOSYSTEMS　52　(1-3)　181-187　1999/10

    DOI： 10.1016/S0303-2647(99)00045-3 　

    ISSN： 0303-2647

  179. Experimental measurement of the intensity profiles of a low-energy electron beam extracted from a scanning tunneling microscope tip by field emission Peer-reviewed

    Kawamoto, I, N Li, T Yoshinobu, H Iwasaki

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS　38　(10)　6172-6173　1999/10

    DOI： 10.1143/JJAP.38.6172 　

    ISSN： 0021-4922

  180. Controllable nanopit formation on Si(001) with a scanning tunneling microscope Peer-reviewed

    N Ueda, K Sudoh, N Li, T Yoshinobu, H Iwasaki

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS　38　(9A)　5236-5238　1999/09

    DOI： 10.1143/JJAP.38.5236 　

    ISSN： 0021-4922

  181. Kinetic roughening in electrodissolution of copper Peer-reviewed

    A Iwamoto, T Yoshinobu, H Iwasaki

    PHYSICAL REVIEW E　59　(5)　5133-5136　1999/05

    DOI： 10.1103/PhysRevE.59.5133 　

    ISSN： 1063-651X

  182. Nano-fabrication on Si oxide Si surface by using STM: a low energy electron beam stimulated reaction Peer-reviewed

    N Li, T Yoshinobu, H Iwasaki

    APPLIED SURFACE SCIENCE　141　(3-4)　305-312　1999/03

    DOI： 10.1016/S0169-4332(98)00516-9 　

    ISSN： 0169-4332

  183. Low energy electron stimulated etching of thin Si-oxide layer in nanometer scale using scanning tunneling microscope Peer-reviewed

    N Li, T Yoshinobu, H Iwasaki

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS　38　(3A)　L252-L254　1999/03

    DOI： 10.1143/jjap.38.L252 　

    ISSN： 0021-4922

  184. Anisotropic waves propagating on two-dimensional arrays of Belousov-Zhabotinsky oscillators Peer-reviewed

    K Suzuki, T Yoshinobu, H Iwasaki

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS　38　(3B)　L345-L348　1999/03

    DOI： 10.1143/jjap.38.L345 　

    ISSN： 0021-4922

  185. Nanofabrication on Si oxide with scanning tunneling microscope: Mechanism of the low-energy electron-stimulated reaction Peer-reviewed

    N Li, T Yoshinobu, H Iwasaki

    APPLIED PHYSICS LETTERS　74　(11)　1621-1623　1999/03

    DOI： 10.1063/1.123636 　

    ISSN： 0003-6951

  186. Statistical analysis of step meandering on Si(113) miscut along a low symmetry azimuth Peer-reviewed

    K Sudoh, T Yoshinobu, H Iwasaki

    SURFACE SCIENCE　419　(2-3)　128-133　1999/01

    DOI： 10.1016/S0039-6028(98)00770-5 　

    ISSN： 0039-6028

  187. Fabrication of nanopit arrays on Si(111) Peer-reviewed

    WC Moon, T Yoshinobu, H Iwasaki

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS　38　(1B)　483-486　1999/01

    DOI： 10.1143/JJAP.38.483 　

    ISSN： 0021-4922

  188. Scanning tunneling microscopy study of the misfit layer compounds (LaSe)(x)NbSe2 and (PbSe)(x)NbSe2 Peer-reviewed

    SA Contera, T Yoshinobu, H Iwasaki, K Kisoda

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS　37　(11)　6157-6160　1998/11

    DOI： 10.1143/JJAP.37.6157 　

    ISSN： 0021-4922

  189. Scanning tunneling microscopy study of faceting on vicinal Si(113) Peer-reviewed

    K Sudoh, T Yoshinobu, H Iwasaki

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS　37　(11)　5870-5874　1998/11

    DOI： 10.1143/JJAP.37.5870 　

    ISSN： 0021-4922

  190. Estimation of Possible Errors in DNA Computing Peer-reviewed

    Y. Aoi, T. Yoshinobu, K. Tanizawa, K. Kinoshita, H. Iwasaki

    Technology Reports of the Osaka University　48　(2333)　301-307　1998/10

  191. Solution of the knapsack problem by deoxyribonucleic acid computing Peer-reviewed

    Y Aoi, T Yoshinobu, K Tanizawa, K Kinoshita, H Iwasaki

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS　37　(10)　5839-5841　1998/10

    DOI： 10.1143/JJAP.37.5839 　

    ISSN： 0021-4922

  192. Low energy electron beam stimulated surface reaction: Selective etching of SiO2/Si using scanning tunneling microscope Peer-reviewed

    N Li, T Yoshinobu, H Iwasaki

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS　37　(8B)　L995-L998　1998/08

    DOI： 10.1143/jjap.37.L995 　

  193. STM study of the reactivity of niobium diselenide in air and N(2) Peer-reviewed

    SA Contera, T Yoshinobu, H Iwasaki, K Kisoda, S Nakashima

    APPLIED SURFACE SCIENCE　130　623-628　1998/06

    DOI： 10.1016/S0169-4332(98)00126-3 　

    ISSN： 0169-4332

  194. Scanning chemical microscope for the visualization of a microscopic pH distribution Peer-reviewed

    M Nakao, S Nomura, T Nakanishi, S Takamatsu, K Tomita, T Yoshinobu, H Iwasaki

    BUNSEKI KAGAKU　47　(6)　369-373　1998/06

    DOI： 10.2116/bunsekikagaku.47.369 　

    ISSN： 0525-1931

  195. Step fluctuations on vicinal Si(113) Peer-reviewed

    K Sudoh, T Yoshinobu, H Iwasaki, ED Williams

    PHYSICAL REVIEW LETTERS　80　(23)　5152-5155　1998/06

    DOI： 10.1103/PhysRevLett.80.5152 　

    ISSN： 0031-9007

    eISSN： 1079-7114

  196. Application of chemical imaging sensor to electro generated pH distribution Peer-reviewed

    T Yoshinobu, H Iwasaki, M Nakao, S Nomura, T Nakanishi, S Takamatsu, K Tomita

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS　37　(3B)　L353-L355　1998/03

    DOI： 10.1143/jjap.37.L353 　

  197. Chemical imaging sensor for observation of microscopic pH-distribution Peer-reviewed

    M Nakao, S Nomura, S Takamatsu, K Tomita, T Yoshinobu, H Iwasaki

    MICROMACHINED DEVICES AND COMPONENTS IV　3514　92-102　1998

    ISSN： 0277-786X

  198. High Resolution Chemical Imaging Sensor using Semiconductor Si Peer-reviewed

    Motoi Nakao, Satoshi Nomura, Shuji Takamatsu, Katsuhiko Tomita, Tatsuo Yoshinobu, Hiroshi Iwasaki

    IEEJ Transactions on Sensors and Micromachines　118　(12)　584-589　1998

    DOI： 10.1541/ieejsmas.118.584 　

    ISSN： 1347-5525 1341-8939

  199. Visualization of pH Change of E. coli with a Novel pH Imaging Microscope Peer-reviewed

    T. Yoshinobu, H. Iwasaki, M. Nakao, S. Nomura, T. Nakanishi, S. Takamatsu, K. Tomita

    Bioimages　5　(4)　143-147　1997/12

  200. Visualization of chemical waves in Belousav-Zhabotinsky reaction by chemical imaging sensors Peer-reviewed

    T Yoshinobu, N Oba, H Iwasaki

    JOURNAL OF THE ELECTROCHEMICAL SOCIETY　144　(11)　3919-3921　1997/11

    DOI： 10.1149/1.1838111 　

    ISSN： 0013-4651

  201. High-resolution pH imaging sensor for microscopic observation of microorganisms Peer-reviewed

    M Nakao, S Inoue, T Yoshinobu, H Iwasaki

    SENSORS AND ACTUATORS B-CHEMICAL　34　(1-3)　234-239　1996/08

    DOI： 10.1016/S0925-4005(96)01903-X 　

    ISSN： 0925-4005

  202. Light scattering by submicron particles on film-coated wafers Peer-reviewed

    H Kondo, S Yanagi, K Takaishi, T Shingyouji, T Yoshinobu, H Iwasaki

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS　35　(5B)　L616-L618　1996/05

    DOI： 10.1143/jjap.35.L616 　

    ISSN： 0021-4922

  203. Chemical-imaging sensor using enzyme Peer-reviewed

    S Inoue, M Nakao, T Yoshinobu, H Iwasaki

    SENSORS AND ACTUATORS B-CHEMICAL　32　(1)　23-26　1996/04

    DOI： 10.1016/0925-4005(96)80104-3 　

    ISSN： 0925-4005

  204. Fluctuations of a single step and surface height on vicinal surfaces Peer-reviewed

    K Sudoh, T Yoshinobu, H Iwasaki, N Akutsu, T Yamamoto

    JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN　65　(4)　988-991　1996/04

    DOI： 10.1143/JPSJ.65.988 　

    ISSN： 0031-9015

  205. Redox potential imaging sensor Peer-reviewed

    N Oba, T Yoshinobu, H Iwasaki

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS　35　(4A)　L460-L463　1996/04

    DOI： 10.1143/jjap.35.L460 　

    ISSN： 0021-4922

  206. Simulation of light scattering by a particle on a film-coated substrate using coupled-dipole method Peer-reviewed

    Hideyuki Kondo, Tatsuo Yoshinobu, Takayuki Shingyouji, Hiroshi Iwasaki

    Optical Review　3　(6 B)　497-500　1996

    Publisher: Optical Society of Japan

    DOI： 10.1007/BF02932057 　

    ISSN： 1340-6000

  207. SCALING OF SI/SIO2 INTERFACE ROUGHNESS Peer-reviewed

    T YOSHINOBU, A IWAMOTO, K SUDOH, H IWASAKI

    JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B　13　(4)　1630-1634　1995/07

    ISSN： 1071-1023

  208. Scaling of Si/SiO2 interface roughness Peer-reviewed

    T. Yoshinobu, A. Iwamoto, K. Sudoh, H. Iwasaki

    Journal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures　13　(4)　1630-1634　1995/07

    Publisher: American Inst of Physics

    DOI： 10.1116/1.587869 　

    ISSN： 0734-211X

  209. High-resolution pH-imaging sensor for microscopic observation of microorganisms

    Motoi Nakao, Shinji Inoue, Tatsuo Yoshinobu, Hiroshi Iwasaki

    International Conference on Solid-State Sensors and Actuators, and Eurosensors IX, Proceedings　2　451-454　1995

    Publisher: IEEE

  210. Subnanosecond in-line soft X-Ray holography using germanium laser in the 20 nm wavelength region Peer-reviewed

    H. Daido, M. S. Schulz, K. Murai, R. Kodama, G. Yuan, J. Goto, K. A. Tanaka, Y. Kato, J. Nakai, K. Shinohara, T. Honda, I. Kodama, H. Iwasaki, T. Yoshinobu, M. Tsukamoto, M. Niibe, Y. Fukuda, D. Neely, A. MacPhee, G. Slark

    Journal of X-Ray Science and Technology　5　(1)　105-120　1995

    DOI： 10.3233/XST-1995-5109 　

    ISSN： 0895-3996

  211. OBSERVATION OF MICROORGANISM COLONIES USING A SCANNING-LASER-BEAM PH-SENSING MICROSCOPE Peer-reviewed

    M NAKAO, S INOUE, R OISHI, T YOSHINOBU, H IWASAKI

    JOURNAL OF FERMENTATION AND BIOENGINEERING　79　(2)　163-166　1995

    DOI： 10.1016/0922-338X(95)94085-6 　

    ISSN： 0922-338X

  212. Scaling analysis of alpha- and poly-Si surface roughness by atomic force microscopy

    T YOSHINOBU, A IWAMOTO, K SUDOH, H IWASAKI

    FRACTAL ASPECTS OF MATERIALS　367　329-334　1995

    ISSN： 0272-9172

  213. Dynamic scaling in electrochemical deposition

    H IWASAKI, A IWAMOTO, K SUDOH, T YOSHINOBU

    FRACTAL ASPECTS OF MATERIALS　367　159-168　1995

    ISSN： 0272-9172

  214. High-speed and high-precision chemical-imaging sensor Peer-reviewed

    Tatsuo Yoshinobu, Noriko Oba, Hiroshi Tanaka, Hiroshi Iwasaki

    Sensors and Actuators: A. Physical　51　(2-3)　231-235　1995

    DOI： 10.1016/S0924-4247(96)01226-5 　

    ISSN： 0924-4247

  215. SCANNING-LASER-BEAM SEMICONDUCTOR PH-IMAGING SENSOR Peer-reviewed

    M NAKAO, T YOSHINOBU, H IWASAKI

    SENSORS AND ACTUATORS B-CHEMICAL　20　(2-3)　119-123　1994/06

    DOI： 10.1016/0925-4005(93)01199-E 　

    ISSN： 0925-4005

  216. STABLE GROWTH AND KINETIC ROUGHENING IN ELECTROCHEMICAL DEPOSITION Peer-reviewed

    A IWAMOTO, T YOSHINOBU, H IWASAKI

    PHYSICAL REVIEW LETTERS　72　(25)　4025-4028　1994/06

    DOI： 10.1103/PhysRevLett.72.4025 　

    ISSN： 0031-9007

  217. CONTROLLED CARBONIZATION OF SI(001) SURFACE USING HYDROCARBON RADICALS IN ULTRAHIGH-VACUUM Peer-reviewed

    T HATAYAMA, Y TARUI, T YOSHINOBU, T FUYUKI, H MATSUNAMI

    JOURNAL OF CRYSTAL GROWTH　136　(1-4)　333-337　1994/03

    DOI： 10.1016/0022-0248(94)90435-9 　

    ISSN： 0022-0248

  218. IMPROVEMENT OF SPATIAL-RESOLUTION OF A LASER-SCANNING PH-IMAGING SENSOR Peer-reviewed

    M NAKAO, T YOSHINOBU, H IWASAKI

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS　33　(3A)　L394-L397　1994/03

    DOI： 10.1143/JJAP.33.L394 　

    ISSN： 0021-4922

  219. ATOMIC CONFIGURATION OF SURFACE SUPERSTRUCTURES IN LAYER-BY-LAYER GROWTH OF CUBIC SIC Peer-reviewed

    T FUYUKI, T YOSHINOBU, H MATSUNAMI

    ADVANCED MATERIALS '93, VI - A & B　19　(A & B)　153-156　1994

  220. RECENT PROGRESS IN COLLISIONALLY-EXCITED X-RAY LASER RESEARCH AT THE INSTITUTE-OF-LASER-ENGINEERING Invited Peer-reviewed

    Y KATO, H DAIDO, R KODAMA, K MURAI, G YUAN, M SCHULZ, M YAMANAKA, M TAKAGI, T KANABE, S NAKAI, D NEELY, A MACPHEE, CLS LEWIS, G SLARK, M NIIBE, M TSUKAMOTO, Y FUKUDA, H TSUNEMI, S NOMOTO, KODAMA, I, T HONDA, K SHINOHARA, H IWASAKI, T YOSHINOBU

    ULTRASHORT WAVELENGTH LASERS II　2012　12-21　1994

  221. MESOSCOPIC ROUGHNESS CHARACTERIZATION OF GROWN SURFACES BY ATOMIC-FORCE MICROSCOPY Peer-reviewed

    T YOSHINOBU, A IWAMOTO, H IWASAKI

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS　33　(1A)　L67-L69　1994/01

    DOI： 10.1143/jjap.33.L67 　

    ISSN： 0021-4922

  222. SCALING ANALYSIS OF SIO2/SI INTERFACE ROUGHNESS BY ATOMIC-FORCE MICROSCOPY Peer-reviewed

    T YOSHINOBU, A IWAMOTO, H IWASAKI

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS　33　(1B)　383-387　1994/01

    DOI： 10.1143/JJAP.33.383 　

    ISSN： 0021-4922

  223. Scaling Analysis of SiO2/Si Interface Roughness by Atomic Force Microscopy

    T. Yoshinobu, A. Iwamoto, H. Iwasaki

    1993 International Conference on Solid State Devices and Materials　612-614　1993/12

  224. 4H-SIC/6H-SIC INTERFACE STRUCTURES STUDIED BY HIGH-RESOLUTION TRANSMISSION ELECTRON-MICROSCOPY Peer-reviewed

    H IWASAKI, S INOUE, T YOSHINOBU, M TARUTANI, Y TAKAI, R SHIMIZU, A ITO, T KIMOTO, H MATSUNAMI

    APPLIED PHYSICS LETTERS　63　(19)　2636-2637　1993/11

    DOI： 10.1063/1.110405 　

    ISSN： 0003-6951

  225. SCALING ANALYSIS OF CHEMICAL-VAPOR-DEPOSITED TUNGSTEN FILMS BY ATOMIC-FORCE MICROSCOPY Peer-reviewed

    T YOSHINOBU, H IWASAKI

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS & EXPRESS LETTERS　32　(10B)　L1562-L1564　1993/10

    DOI： 10.1143/JJAP.32.L1562 　

    ISSN： 0021-4922

  226. SELF-AFFINE GROWTH OF COPPER ELECTRODEPOSITS Peer-reviewed

    H IWASAKI, T YOSHINOBU

    PHYSICAL REVIEW B　48　(11)　8282-8285　1993/09

    DOI： 10.1103/PhysRevB.48.8282 　

    ISSN： 0163-1829

  227. ATOMIC LAYER EPITAXY CONTROLLED BY SURFACE SUPERSTRUCTURES IN SIC Peer-reviewed

    T FUYUKI, T YOSHINOBU, H MATSUNAMI

    THIN SOLID FILMS　225　(1-2)　225-229　1993/03

    ISSN： 0040-6090

  228. SOFT-X-RAY HOLOGRAPHY USING AN X-RAY LASER AT 23.2 23.6 NM AND 19.6 NM Peer-reviewed

    MS SCHULZ, H DAIDO, K MURAI, Y KATO, R KODAMA, G YUAN, S NAKAI, H IWASAKI, T YOSHINOBU, K SHINOHARA, KODAMA, I, T HONDA, D NEELY, G SLARK

    OSA PROCEEDINGS ON SHORTWAVELENGTH V: PHYSICS WITH INTENSE LASER PULSES　17　226-230　1993

  229. CRACKING OF SATURATED-HYDROCARBON GAS MOLECULAR-BEAM FOR CARBONIZATION OF SI(001) SURFACE Peer-reviewed

    T YOSHINOBU, H MITSUI, Y TARUI, T FUYUKI, H MATSUNAMI

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS & EXPRESS LETTERS　31　(11B)　L1580-L1582　1992/11

    ISSN： 0021-4922

  230. UNDOPED SILICON LAYERS GROWN BY GAS SOURCE MOLECULAR-BEAM EPITAXY USING SI2H6 Peer-reviewed

    T YOSHINOBU, T FUYUKI, H MATSUNAMI

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS & EXPRESS LETTERS　31　(9A)　L1213-L1215　1992/09

    ISSN： 0021-4922

  231. HETEROEPITAXIAL GROWTH OF SINGLE CRYSTALLINE 3C-SIC ON SI SUBSTRATES BY GAS SOURCE MOLECULAR-BEAM EPITAXY Peer-reviewed

    T YOSHINOBU, H MITSUI, Y TARUI, T FUYUKI, H MATSUNAMI

    JOURNAL OF APPLIED PHYSICS　72　(5)　2006-2013　1992/09

    DOI： 10.1063/1.351628 　

    ISSN： 0021-8979

  232. LATTICE-MATCHED EPITAXIAL-GROWTH OF SINGLE CRYSTALLINE 3C-SIC ON 6H-SIC SUBSTRATES BY GAS SOURCE MOLECULAR-BEAM EPITAXY Peer-reviewed

    T YOSHINOBU, H MITSUI, IZUMIKAWA, I, T FUYUKI, H MATSUNAMI

    APPLIED PHYSICS LETTERS　60　(7)　824-826　1992/02

    DOI： 10.1063/1.107430 　

    ISSN： 0003-6951

  233. Atomic-Layer Level Control in SiC Crystal Growth Using Gas Source Molecular Beam Epitaxy Peer-reviewed

    Takashi Fuyuki, Tatsuo Yoshinobu, Hiroyuki Matsunami

    Shinku　35　(11)　905-911　1992

    DOI： 10.3131/jvsj.35.905 　

    ISSN： 0559-8516

  234. DYNAMIC REFLECTION HIGH-ENERGY ELECTRON-DIFFRACTION OBSERVATION OF 3C-SIC(001) SURFACE RECONSTRUCTION UNDER SI2H6 BEAM IRRADIATION Peer-reviewed

    T YOSHINOBU, IZUMIKAWA, I, H MITSUI, T FUYUKI, H MATSUNAMI

    APPLIED PHYSICS LETTERS　59　(22)　2844-2846　1991/11

    DOI： 10.1063/1.105852 　

    ISSN： 0003-6951

  235. INTERFACE MODIFICATION BY HYDROCARBON-GAS MOLECULAR-BEAMS IN HETEROEPITAXY OF SIC ON SI Peer-reviewed

    T YOSHINOBU, T FUYUKI, H MATSUNAMI

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS & EXPRESS LETTERS　30　(6B)　L1086-L1088　1991/06

    ISSN： 0021-4922

  236. ATOMIC LEVEL CONTROL IN CRYSTAL-GROWTH UTILIZING RECONSTRUCTION OF THE SURFACE SUPERSTRUCTURE

    T FUYUKI, T YOSHINOBU, HY MATSUNAMI

    ATOMIC LAYER GROWTH AND PROCESSING　222　207-211　1991

  237. CARBONIZATION DYNAMICS OF SILICON SURFACES BY HYDROCARBON-GAS MOLECULAR-BEAMS

    T YOSHINOBU, T FUYUKI, H MATSUNAMI

    SILICON MOLECULAR BEAM EPITAXY　220　575-580　1991

  238. ATOMIC LEVEL CONTROL IN GAS SOURCE MBE GROWTH OF CUBIC SIC Peer-reviewed

    T YOSHINOBU, M NAKAYAMA, H SHIOMI, T FUYUKI, H MATSUNAMI

    JOURNAL OF CRYSTAL GROWTH　99　(1-4)　520-524　1990/01

    ISSN： 0022-0248

  239. Atomic Layer Control in Cubic SiC Growth Utilizing Surface Superstructure in Gas Source MBE

    H. Matsunami, M. Nakayama, T. Yoshinobu, H. Shiomi, T. Fuyuki

    Springer Proceedings in Physics, "Amorphous and Crystalline Silicon Carbide and Related Materials II"　43　157-161　1989/12

  240. ATOMIC LAYER EPITAXY OF CUBIC SIC BY GAS SOURCE MBE USING SURFACE SUPERSTRUCTURE Peer-reviewed

    T FUYUKI, M NAKAYAMA, T YOSHINOBU, H SHIOMI, H MATSUNAMI

    JOURNAL OF CRYSTAL GROWTH　95　(1-4)　461-463　1989/02

    DOI： 10.1016/0022-0248(89)90442-9 　

    ISSN： 0022-0248

Show all ︎Show first 5

Misc. 46

  1. Light-addressable potentiometric sensors for cell monitoring and biosensing Peer-reviewed

    Tatsuo Yoshinobu, Michael J. Schöning

    Current Opinion in Electrochemistry　28　2021/08/01

    Publisher: Elsevier B.V.

    DOI： 10.1016/j.coelec.2021.100727 　

    ISSN： 2451-9111 2451-9103

  2. Light-Addressable Potentiometric Sensors for Quantitative Spatial Imaging of Chemical Species Peer-reviewed

    Tatsuo Yoshinobu, Ko-ichiro Miyamoto, Carl Frederik Werner, Arshak Poghossian, Torsten Wagner, Michael J. Schöning

    Annual Review of Analytical Chemistry　10　(1)　225-246　2017/06/12

    Publisher: Annual Reviews

    DOI： 10.1146/annurev-anchem-061516-045158 　

    ISSN： 1936-1327

    eISSN： 1936-1335

    More details Close

    A light-addressable potentiometric sensor (LAPS) is a semiconductor-based chemical sensor, in which a measurement site on the sensing surface is defined by illumination. This light addressability can be applied to visualize the spatial distribution of pH or the concentration of a specific chemical species, with potential applications in the fields of chemistry, materials science, biology, and medicine. In this review, the features of this chemical imaging sensor technology are compared with those of other technologies. Instrumentation, principles of operation, and various measurement modes of chemical imaging sensor systems are described. The review discusses and summarizes state-of-the-art technologies, especially with regard to the spatial resolution and measurement speed; for example, a high spatial resolution in a submicron range and a readout speed in the range of several tens of thousands of pixels per second have been achieved with the LAPS. The possibility of combining this technology with microfluidic devices and other potential future developments are discussed.

  3. Recent developments of chemical imaging sensor systems based on the principle of the light-addressable potentiometric sensor Peer-reviewed

    Tatsuo Yoshinobu, Ko-ichiro Miyamoto, Torsten Wagner, Michael J. Schöning

    Sensors and Actuators B: Chemical　207　926-932　2015/02

    Publisher: Elsevier BV

    DOI： 10.1016/j.snb.2014.09.002 　

    ISSN： 0925-4005

  4. The light-addressable potentiometric sensor for multi-ion sensing and imaging Peer-reviewed

    T. Yoshinobu, H. Iwasaki, Y. Ui, K. Furuichi, Yu. Ermolenko, Yu. Mourzina, T. Wagner, N. Näther, M.J. Schöning

    Methods　37　(1)　94-102　2005/09

    Publisher: Elsevier BV

    DOI： 10.1016/j.ymeth.2005.05.020 　

    ISSN： 1046-2023

  5. EVALUATION OF DIFFUSION COEFFICIENTS OF IONS USING CHEMICAL IMAGING SENSOR

    Proceedings of the Chemical Sensor Symposium　61　64-66　2017/03

    Publisher: 電気化学会化学センサ研究会

  6. NOVEL CELL MIGRATION ASSAY UTILIZING SPIM MODE OF CHEMICAL IMAGING SENSOR

    Proceedings of the Chemical Sensor Symposium　60　66-68　2016/03

    Publisher: 電気化学会化学センサ研究会

  7. In situ pH measurement in the vicinity of anode by the chemical image sensor

    32　4p　2015/10/28

    Publisher: Institute of Electrical Engineers of Japan

  8. Fabrication and application of fluidic device utilizing 3D-printing technique

    32　1-4　2015/10/28

    Publisher: Institute of Electrical Engineers of Japan

  9. Development of a miniaturized sensor head for chemical imaging and its application to Escherichia coli colony detection

    Proceedings of the Chemical Sensor Symposium　56　34-36　2014/03

    Publisher: 電気化学会化学センサ研究会

  10. Development of chemical imaging sensor systems based on the light-addressable potentiometric sensor

    Chemical sensors　30　(2)　48-53　2014

    Publisher: 化学センサ研究会

  11. Device Simulation of the Light-addressable Potentiometric Sensor for High Spatial Resolution

    Proceedings of the Chemical Sensor Symposium　55　25-27　2013/09

    Publisher: 電気化学会化学センサ研究会

  12. Muscle tissue actuator driven with light-gated ion channels channelrhodopsin

    Masahiro Shimizu, Kota Miyasaka, Koichiro Miyamoto, Toshifumi Asano, Tatsuo Yoshinobu, Hiromu Yawo, Toshihiko Ogura, Akio Ishiguro, Koh Hosoda

    Procedia CIRP　5　169-174　2013/01/01

    DOI： 10.1016/j.procir.2013.01.034 　

  13. Measurement of Hemodynamic Responses of the Motor Cortex and Its Application to BCI

    KANOH Shin'ichiro, YOSHINOBU Tatsuo

    50　(1)　62-67　2011/01/10

    Publisher: 計測自動制御学会

    ISSN： 0453-4662

  14. A BCI system that detects visual event-related potentials for online cursor control

    FUJIMAKI Raita, KANOH Shin'ichiro, MIYAMOTO Ko-ichiro, YOSHINOBU Tatsuo

    IEICE technical report　110　(295)　59-64　2010/11/11

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    A BCI (brain-computer interface) system that detects visual ERPs (event-related potentials) to control a cursor on the computer screen is proposed in this paper. The ERPs induced by the selective attention to one of the eight circles around the cursor which was blinked in random order, was used to control the cursor movement. Information bit rates for five subjects were about 11 to 16 bit/min. Improvement of an information bit rate and increasing a speed of cursor movement are left for further studies.

  15. Generation of spatial filter by ICA for detecting motor-related oscillatory EEG

    ICHIMURA Hiroki, KANOH Shin'ichiro, MIYAMOTO Ko-ichiro, YOSHINOBU Tatsuo

    IEICE technical report　110　(295)　53-58　2010/11/11

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    To detect the imagined limb from EEG related to the motor imagery for the use in BCI, the spatial filter using neighboring channels was commonly used. But, the spatial filter has been selected mainly by the empirical method on trial-and-error basis. In this study, we recorded the EEG during left hand, right hand and feet motor imagery from five subjects and the ICA was applied to discovering the spatial filter for extracting event-related EEG components to the motor imagery. It was shown that the spatial filter can be generated semi-automatically by applying ICA to recorded multichannel EEG.

  16. Effect of NIRS-based neurofeedback on brain activity during motor imagery : Evaluation by NIRS measurement

    IIZUKA Kei, KANOH Shin'ichiro, MIYAMOTO Ko-ichiro, YOSHINOBU Tatsuo, KAWASHIMA Ryuta

    IEICE technical report. Neurocomputing　109　(280)　59-64　2009/11/05

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    The authors have evaluated the effect of neurofeedback training for subjects on the brain activity to be used in the brain-computer interface (BCI) which detected motor imagery from cerebrum blood flow measured by NIRS (near-infrared spectroscopy). The concentrations of oxy-hemoglobin on motor cortex during motor imagery of a subject's right hand were measured, and were visually fed back to the subject. It was shown that the training enhanced the cerebral blood flow during motor imagery on two out of five subjects. Investigation of more effective training and neurofeedback methods were left for the further study.

  17. An Auditory BCI System using Auditory Stream Segregation

    KANOH Shin'ichiro, YAMAGISHI Tomohisa, MIYAMOGO Ko-ichiro, YOSHINOBU Tatsuo

    IEICE technical report　107　(542)　445-449　2008/03/05

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    An auditory brain-computer interface (BCI) which detected event-related potential (ERP) elicited by selective attention to one of the tone streams was proposed. Each tone in two kinds of auditory oddball sequences with different frequencies of standard tones was presented alternatively to subjects, and they were perceived by subjects as two kinds of segregated streams. Event-related potentials elicited by two kinds of deviant tones were classified by linear discriminant analysis (LDA) to find which streams subjects paid selective attention. By the experiments to six healthy subjects, it was shown that this system could achieve binary selection of two kinds of tone streams.

  18. A BCI system using event-related potentials during selective attention to tone frequencies

    YAMAGISHI Tomohisa, KANOH Shin'ichiro, MIYAMOTO Ko-ichiro, YOSHINOBU Tatsuo

    IEICE technical report　107　(351)　37-40　2007/11/15

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    A Brain-Computer Interface (BCI) is a communication system that translates brain activity into commands for controlling a computer or an external device for disabled users like amyotrophic lateral sclerosis (ALS) patients. We developed a BCI system using event-related potentials during selective attention to tone frequencies and a classification accuracy of detecting event-related potentials caused by two kinds of deviant stimulation with different frequencies was evaluated. A classification accuracy of 60〜90% and a classification rate of 3〜4bit/min were obtained respectively for two subjects.

  19. Effect of feedback training on BCI using EEG during motor imagery

    TAKAHASHI Masafumi, KANOH Shin'ichiro, MIYAMOTO Ko-ichiro, YOSHINOBU Tatsuo

    IEICE technical report　107　(351)　33-36　2007/11/15

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    In this study, we investigated the effect of feedback training to the user to improve the accuracy of command detection on BCI system which detects a command from EEG during motor imagery. During the feedback training session, subjects were visually presented a white bar on LCD whose length was proportional to the EEG band power of the specific frequency range. The effects of feedback training were evaluated in terms of the change of the band power and the accuracy of command detection. It was shown that the feedback training was effective on two subjects out of four.

  20. Biomedical Signal Detection and Application for Neuro-Muscular Control by FES (Functional Electrical Stimulation)

    HOSHIMIYA Nozomu, KANOH Shin'ichiro, YOSHINOBU Tatsuo

    IEICE technical report　107　(263)　51-56　2007/10/11

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    Research activities on Functional Electrical Stimulation (FES) were described by focussing to the several research activities on biomedical signal detection methods. Recent activities on Brain-Computer Interface (BCI) were also described. In addition, the historical first step of the NC research group was also briefly described.

  21. A generic platform for realizing an EEG-based online BCI system

    SUSILA I Putu, KANOH Shin'ichiro, MIYAMOTO Koichiro, YOSHINOBU Tatsuo, HOSHIMIYA Nozomu

    IEICE technical report　107　(263)　99-104　2007/10/11

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    A generic platform for realizing online brain-computer interface (BCI) system was developed. The platform is module-based, and has a GUI-based diagram editor for building desired system. The platform can be extended easily, and supports multiple acquisition hardware and operating system. An online BCI system that detects the band power of EEG beta oscillation during hand or foot motor imagery was built on this platform. We confirmed that the system was able to realize an online BCI system. The platform is extendable, and a various system can be realized by adding new modules.

  22. A Basic Study on Brain-Computer Interface to Detect Foot Movement Imagery from EEG

    KANOH Shin'ichiro, SCHERER Reinhold, YOSHINOBU Tatsuo, HOSHIMIYA Nozomu, PFURTSCHELLER Gert

    IEICE technical report　106　(370)　9-12　2006/11/15

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    EEG-based asynchronous brain-computer interface (BCI) system to realize binary switch by using simple thresholding of EEG beta band power was tested to six healthy subjects. EEG signal was measured from a bipolar channel on the vertex of the head, and was band-pass filtered, squared and smoothed on-line to extract the band power of beta oscillation. Subjects were requested to imagine foot movement, and if the band power exceeded a pre-defined threshold value, a command was generated. It was shown that two subjects out of six were able to induce bursts of beta oscillations by foot movement imagery, and binary commands could be detected in higher correct rates by these subjects.

  23. A human-computer interfacing system for menu selection using AC EOG

    KANOH Shin'ichiro, YOSHINOBU Tatsuo, HOSHIMIYA Nozomu

    IEICE technical report　105　(655)　33-36　2006/03/08

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    The human intafacing system to detect the direction and distance of voluntary eye gaze movement from EOG (electrooculogram) was investigated. In this study, a method to detect 8-class directions and 2-class distances of voluntary eye gaze movements from AC-amplified vertical and horizontal EOGs was proposed. This technique could avoid strict eye tracking which required DC amplification of very small signal. It was found that this technique enabled detection of eye gaze movement with high correct rate by AC-amplified EOG. It may be useful to develop robust human inter facing system based on menu selection for severely paralyzed patients.

  24. 半導体化学イメージセンサのマイクロ流路デバイスへの応用

    宇井 靖人, 吉信 達夫, 岩崎 裕

    Proceedings of the Chemical Sensor Symposium　38　79-81　2004/03

    Publisher: 電気化学会化学センサ研究会

  25. Nanolithography on SiO2/Si with a scanning tunnelling microscope

    H Iwasaki, T Yoshinobu, K Sudoh

    NANOTECHNOLOGY　14　(11)　R55-R62　2003/11

    ISSN： 0957-4484

  26. 半導体化学イメージセンサによるマイクロ流路内のイオン濃度分布測定

    宇井 靖人, 吉信 達夫, 岩崎 裕

    Proceedings of the Chemical Sensor Symposium　37　13-15　2003/09

    Publisher: 電気化学会化学センサ研究会

  27. In situ observation and analysis on tetragonal lysozyme (110) surface during crystal growth

    Kimura K., Yoshinobu T., Sudoh K., Iwasaki H.

    Meeting abstracts of the Physical Society of Japan　58　(2)　769-769　2003/08/15

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  28. 半導体化学イメージセンサの開発と応用 (特集 マテリアルインテグレーション--材料・生体・情報の融合を目指して(1))

    岩崎 裕, 吉信 達夫

    マテリアルインテグレ-ション　15　(7)　73-76　2002/07

    Publisher: ティ-・アイ・シ-

    ISSN： 1344-7858

  29. 原子間力顕微鏡を用いたシリコン表面の局所陽極酸化 (特集 マテリアルインテグレーション--材料・生体・情報の融合を目指して(1))

    吉信 達夫, 岩崎 裕

    マテリアルインテグレ-ション　15　(7)　77-80　2002/07

    Publisher: ティ-・アイ・シ-

    ISSN： 1344-7858

  30. Nanometer-scale anodic oxidation of Si by atomic force microscope

    2001　(2)　281-281　2001/09/01

  31. Nanotribology of Si Oxide Layers on Si Surfaces by AFM

    MOON Won-chul, YOSHINOBU Tatsuo, IWASAKI Hiroshi

    44　(3)　393-393　2001/03/20

    ISSN： 0559-8516

  32. Generation and motion of spiral waves in the presence of defects

    Suzuki K., Yoshinobu T., Iwasaki H.

    Meeting abstracts of the Physical Society of Japan　55　(1)　250-250　2000/03/10

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  33. Nanofabrication on Semiconductor Surfaces by the Scanning Probe Technique

    SUDOH K., LI N., KAWAMOTO I., YOSHINOBU T., IWASAKI H.

    Electron-microscopy　34　173-176　1999/11/01

    Publisher: 日本電子顕微鏡学会

    ISSN： 0417-0326

  34. Diffusion of Ions in Aqueous Electrolyte Solutions Measured by a pH Imaging Sensor

    IWASAKI Hiroshi, HARADA Tetsurou, ISMAIL Abu Bakar Md., YOSHINOBU Tatsuo

    1999　(28)　29-34　1999/09/13

  35. 25aT-5 Transmission of chemical waves through a narrow gap

    SUZUKI K, YOSHINOBU T, IWASAKI H

    Meeting abstracts of the Physical Society of Japan　54　(2)　216-216　1999/09/03

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  36. 28a-P-9 The pattern formations in two-dimensional dot-arrays for BZ reactions

    Suzuki Kenji, Yoshinobu Tatuo, Iwasaki Hiroshi

    Meeting abstracts of the Physical Society of Japan　54　(1)　639-639　1999/03/15

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  37. Low Energy Electron Stimulated Etching of Thin Si Oxide Layer Using STM : Nano-fabrication with A Localized Low-energy e-Beam

    LI Nan, YOSHINOBU Tatsuo, IWASAKI Hiroshi

    42　(3)　488-488　1999/03

    ISSN： 0559-8516

  38. Step Fluctuations on Si(113)

    SUDOH Koichi, YOSHINOBU Tatsuo, IWASAKI Hiroshi

    42　(3)　421-421　1999/03

    ISSN： 0559-8516

  39. STM Nano Fabrication Process Using SiO2 Film.

    IWASAKI Hiroshi, LI Nan, YOSHINOBU Tatsuo

    J. Surf. Sci. Soc. Jpn.　20　(6)　435-442　1999

    Publisher: The Surface Science Society of Japan

    DOI： 10.1380/jsssj.20.435 　

    ISSN： 0388-5321 1881-4743

    More details Close

    Combined with thermal annealing, the locally confined low energy electron-beam from a scanning tunneling microscope (STM) tip can be used for nanofabrication of Si oxide film on Si substrate as nano-lithography mask; the oxide layer within the field emission a-beam exposed area can be decomposed, and then evacuated from the surface at elevated temperatures of about 600°C. Different manometer scale patterns of the oxide windows on Si substrate such as dot window arrays, lines, and circles can be formed. The minimum feature size attained so far is 25nm and the rms edge roughness of line patterns is less than 3.5nm. Mechanism and controllability of the STM nanofabrication processing are discussed.

  40. 光走査型化学顕微鏡による微生物代謝活動の観察

    中尾 基, 野村 聡, 高松 修司, 冨田 勝彦, 吉信 達夫, 岩崎 裕

    バイオイメージング　6　(3)　68-69　1997/10/01

    ISSN： 0919-4916

  41. Imaging of microbial colonies by pH-imaging sensor

    IWASAKI Hiroshi, YOSHINOBU Tatsuo

    66　(5)　488-489　1997/05/10

    ISSN： 0369-8009

  42. Kinetic Roughening in Electrochemical Deposition of Copper : Simulation Study

    Iwamoto A, Yoshinobu T, Iwasaki H

    Abstracts of the meeting of the Physical Society of Japan. Annual meeting　50　(3)　570-570　1995/03/16

    Publisher: The Physical Society of Japan (JPS)

  43. レ-ザ-ビ-ム走査型バイオセンシング顕微鏡の開発基礎研究

    岩崎 裕, 吉信 達夫

    旭硝子財団助成研究成果報告　(1995)　p411-417　1995

    Publisher: 旭硝子財団

    ISSN： 0919-9179

  44. Thermal and kinetic surface roughening studied by scanning tunneling microscopy and atomic force microscopy

    H Iwasaki, T Yoshinobu

    PHASE TRANSITIONS　53　(2-4)　235-248　1995

    ISSN： 0141-1594

  45. 3a-YH-7 Fluctuations of Steps and Surfaces on Vicinal Surfaces

    Sudoh K, Yoshinobu T, Iwasaki H, Akutsu N, Akutsu Y, Yamamoto T

    Abstracts of the meeting of the Physical Society of Japan. Sectional meeting　1994　(2)　8-8　1994/08/16

    Publisher: The Physical Society of Japan (JPS)

  46. 4p-E-5 Kinetic Roughening of Electrochemically Deposited Copper Surfaces

    Iwamoto A, Yoshinobu T, Iwasaki H

    Abstracts of the meeting of the Physical Society of Japan. Sectional meeting　1994　(3)　497-497　1994/08/16

    Publisher: The Physical Society of Japan (JPS)

Show all ︎Show first 5

Books and Other Publications 5

  1. Encyclopedia of Interfacial Chemistry: Surface Science and Electrochemistry, ed. K. Wandelt

    M. J. Schöning, T. Wagner, A. Poghossian, K. Miyamoto, C. F. Werner, S. Krause, T. Yoshinobu

    Elsevier　2018

    ISBN: 9780128097397

  2. Label-Free Biosensing: Advanced Materials, Devices and Applications (Springer Series on Chemical Sensors and Biosensors), eds. M. J. Schöning and A. Poghossian

    T. Yoshinobu, S. Krause, K. Miyamoto, C. F. Werner, A. Poghossian, T. Wagner, M. J. Schöning

    Springer　2018

    ISBN: 9783319752198

  3. 先進化学センサ―ガス・バイオ・イオンセンシングの最新技術 電気化学会化学センサ研究会編

    吉信 達夫

    株式会社ティー・アイ・シィー　2008/06

    ISBN: 4924890707

  4. Nano-Biomedical Engineering 2012, ed. T. Yamaguchi

    T. Yoshinobu, K. Miyamoto, T. Wagner, M. J. Schöning

    Imperial College Press　2012

    ISBN: 9781848169050

  5. Nano-Biomedical Engineering 2009, ed. T. Yamaguchi

    T. Yoshinobu, K. Miyamoto, S. Kanoh, T. Wagner, M. J. Schöning

    Imperial College Press　2009

    ISBN: 9781848163522

Presentations 169

  1. (Plenary Lecture) Light-addressable Potentiometric Sensors and Related Technologies for Biological and Electrochemical Systems International-presentation Invited

    T. Yoshinobu

    4th European Biosensor Symposium 2023

  2. (Invited Talk) Applications of Chemical Imaging Sensor in the Field of Electrochemistry International-presentation Invited

    K. Miyamoto, T. Yoshinobu

    2018 International Conference on Solid-State Devices and Materials (SSDM 2018)　2018/09/09

  3. (Invited Talk) On the Possibility of LAPS as a Sensing Element in Microfluidic Devices International-presentation Invited

    T. Yoshinobu

    12th Asian Conference on Chemical Sensors (ACCS2017)　2017/11/12

  4. (Keynote Lecture) Applications of a Chemical Imaging Sensor to Micro-volume Samples International-presentation Invited

    K. Miyamoto, T. Yoshinobu

    Engineering of Functional Interfaces 2017 (EnFI2017)　2017/08/28

  5. (Keynote Lecture) Application of a Chemical Imaging Sensor to Electrochemical Systems International-presentation Invited

    T. Yoshinobu

    7th Kurt-Schwabe-Symposium　2016/09/04

  6. (Invited Talk) Development of LAPS-based Chemical Imaging Systems and their Applications International-presentation Invited

    T. Yoshinobu

    11th Asian Conference on Chemical Sensors (ACCS2015)　2015/11/16

  7. (Keynote Lecture) Recent Developments and Applications of the Chemical Imaging Sensor Systems International-presentation Invited

    T. Yoshinobu

    4th International Symposium on Sensor Science (I3S2015)　2015/07/13

  8. (Invited Talk) Miniaturized and High-Speed Chemical / Bio-Imaging System International-presentation Invited

    T. Yoshinobu

    4th IEEE International NanoElectronics Conference (INEC2011)　2011/06/21

  9. Effect of Parylene Coating on an Ion-selective Membrane-modified Light-addressable Potentiometric Sensor

    A. Matsumoto, Y. Hemmi, H. Matsui, K. Miyamoto, T. Yoshinobu, C. F. Werner

    16th International Workshop on Engineering of Functional Interfaces (EnFI2025)

  10. Sodium-sensitive Capacitive Field-Effect Sensor

    S. Beging, K. Miyamoto, T. Wagner, T. Yoshinobu, M. J. Schöning

    16th International Workshop on Engineering of Functional Interfaces (EnFI2025)

  11. Scanning Photoelectron Yield Spectroscopy for Visualization of Hydrogen in Steel Specimen

    K. Miyamoto, T. Yoshinobu

    16th International Workshop on Engineering of Functional Interfaces (EnFI2025)

  12. Thermally-drawn-Fiber-based Probe for Multiplexed Ion Monitoring

    J. Wu, T. Saizaki, T. Yoshinobu, Y. Guo

    15th Asian Conference on Chemical Sensors (ACCS 2024)

  13. In-situ Measurement of the Work Function of Steel Surface by Photoelectron Yield Spectroscopy under Atmospheric Condition

    K. Miyamoto, T. Yoshinobu

    15th International Workshop on Engineering of Functional Interfaces (EnFI 2024)

  14. Microbaial Counting in an Array of Microchambers Combined with a Chemical Imaging Sensor International-presentation

    K. Miyamoto, Y. Horie, R. Arai, C. F. Werner, T. Yoshinobu

    The 27th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS 2023)

  15. In vivo Multi-ion Monitoring with Thermally Drawn All-in-fiber Probe International-presentation

    J. Wu, K. Nagamine, T. Yoshinobu, Y. Guo

    74th Annual Meeting of the International Society of Electrochemistry

  16. Silk-fibroin as Immobilization Matrix for Enzymes on Light-addressable Potentiometric Biosensors International-presentation

    K. A. Janus, A. Drinic, K. Miyamoto, M. Keusgen, A. Kopp, M. J. Schöning, T. Yoshinobu

    4th European Biosensor Symposium 2023

  17. Microbial Counting in a Multi-Chamber Microfluidic Device Combined with a Chemical Imaging Sensor International-presentation

    K. Miyamoto, R. Arai, S. Kawashima, C. F. Werner, T. Yoshinobu

    4th European Biosensor Symposium 2023

  18. Biocompatible Enzyme Immobilization Matrix for Light-addressable Potentiometric Biosensor Applications International-presentation

    K.A. Janus, A. Drinic, K. Miyamoto, M. Keusgen, A. Kopp, M.J. Schöning, T. Yoshinobu

    14th International Workshop on Engineering of Functional Interfaces (EnFI 20023)

  19. LAPS-based Multi Measurement Cell Array Sensor International-presentation

    C. F. Werner, Y. Takahashi, A. Yamamoto, K. Miyamoto, T. Yoshinobu, M. Noda

    13th International Workshop on Engineering of Functional Interfaces (EnFI 2022)

  20. Visualization of pH Distribution in a Vertical Cross Section of Plant Rhizosphere by a Chemical Imaging Senso International-presentation

    K. Miyamoto, D. Sato, C.F. Werner, T. Yoshinobu

    13th International Workshop on Engineering of Functional Interfaces (EnFI 2022)

  21. Impedance Mapping of Cell Layer Cultured on Field-Effect Chemical Sensor International-presentation

    K. Miyamoto, D. Suzuki, C. F. Werner, T. Yoshinobu

    8th International Symposium on Control of Semiconductor Interfaces (ISCSI-VIII)

  22. Biochemical Sensors Coupled with Multifunctional Fibers for Label-free Imaging in the Brain and Beyond International-presentation

    Y. Guo, S. Handa, C. F. Werner, K. Miyamoto, P. Anikeeva, T. Yoshinobu

    13th Asian Conference on Chemical Sensors (ACCS 2019)

  23. pH Change in Rhizosphere Measured by a LAPS International-presentation

    C. F. Werner, D. Sato, K. Miyamoto, T. Wagner, M. J. Schöning, T. Yoshinobu

    12th International Workshop on Engineering of Functional Interfaces (EnFI 2019)　2019/07/08

  24. Real-time Monitoring of Ion Concentration Distributions with LAPS International-presentation

    C. F. Werner, S. Taharima, K. Miyamoto, T. Wagner, M. J. Schöning, T. Yoshinobu

    12th International Workshop on Engineering of Functional Interfaces (EnFI 2019)　2019/07/08

  25. SPIM Gas Sensor Equipped with a Ti/Au Thin-film Micro-heater International-presentation

    M. Wang, H. A. Truong, C. F. Werner, K. Miyamoto, T. Yoshinobu

    12th International Workshop on Engineering of Functional Interfaces (EnFI 2019)　2019/07/08

  26. Scanning Photo-induced Impedance Microscopy to Characterize Biodegradable Polymers International-presentation

    C. F. Werner, S. Aoki, K. Miyamoto, T. Wagner, M. J. Schöning, T. Yoshinobu

    10th International Conference on Molecular Electronics & BioElectronics (M&BE10)　2019/06/25

  27. In situ Observation of Crevice Corrosion by a Modified Chemical Imaging Sensor System International-presentation

    K. Miyamoto, T. Yoshinobu

    8th Kurt Schwabe Symposium (jointly organized with RSE-SEE 7)　2019/05/28

  28. Imaging Detection of Ethanol Vapor by Scanning Photo-induced Impedance Microscopy with Suspended-gate Structure International-presentation

    M. Wang, H. A. Truong, C. F. Werner, K. Miyamoto, T. Yoshinobu

    18th International Symposium on Olfaction and Electronic Nose (ISOEN 2019)　2019/05/28

  29. Impedance Mapping of a Defect in a Cell Layer Cultured Directly on a Chemical Imaging Sensor International-presentation

    K. Miyamoto, D. Suzuki, C. F. Werner, T. Yoshinobu

    Electrochemical Micro & Nano System Technologies 2018 (EMNT 2018)　2018/08/29

  30. A Chemical Imaging Sensor with Multi-well Structure for High-throughput Analysis International-presentation

    H. A. Truong, C. F. Werner, K. Miyamoto, T. Yoshinobu

    6th International Symposium on Sensor Science (I3S 2018)　2018/08/06

  31. Microwell-based Microfluidic Device to Estimate the Living Cell Concentration International-presentation

    C. F. Werner, S. Kawashima, K. Miyamoto, T. Yoshinobu

    6th International Symposium on Sensor Science (I3S 2018)　2018/08/06

  32. pH Imaging of Ion Diffusion at Laminar Flow Interface and Estimation of Diffusion Coefficients International-presentation

    K. Miyamoto, S. Naito, C. F. Werner, S. Uno, T. Yoshinobu

    17th International Meeting on Chemical Sensors (IMCS 2018)　2018/07/15

  33. Characterization of Biodegradable Polymers with Scanning Photo-induced Impedance Microscopy International-presentation

    C. F. Werner, S. Aoki, K. Miyamoto, T. Wagner, M. J. Schöning, T. Yoshinobu

    11th International Workshop on Engineering of Functional Interfaces (EnFI 2018)　2018/07/01

  34. (Poster Award) A Gas-sensitive SPIM Sensor for Detection of Ethanol Using SnO2 as Sensing Element International-presentation

    M. Wang, H. A. Truong, C. F. Werner, K. Miyamoto, T. Yoshinobu

    11th International Workshop on Engineering of Functional Interfaces (EnFI 2018)　2018/07/01

  35. Effect of Light Intensity towards the Signal of a Light-addressable Potentiometric Sensor International-presentation

    C. F. Werner, K. Miyamoto, M. J. Schoning, T. Wagner, T. Yoshinobu

    22nd Topical Meeting of the International Society of Electrochemistry　2018/04/15

  36. Gas-imaging Sensor Based on Metal Oxide and Field Effect Structure International-presentation

    M. Wang, K. Miyamoto, H. A. Truong, C. F. Werner, T. Yoshinobu

    22nd Topical Meeting of the International Society of Electrochemistry　2018/04/15

  37. Visualization of the Barrier Function of an Epithelial Cell Layer by Chemical Imaging Sensor and its Future Application International-presentation

    K. Miyamoto, D. Suzuki, S. Uno, C. F. Werner, Y. Yanase, T. Yoshinobu

    22nd Topical Meeting of the International Society of Electrochemistry　2018/04/15

  38. Multi-well Sensor Platform Based on a Partially Etched Structure of Light-addressable Potentiometric Sensor International-presentation

    H. A. Truong, K. Miyamoto, C. F. Werner, T. Yoshinobu

    22nd Topical Meeting of the International Society of Electrochemistry　2018/04/15

  39. Restraining the Diffusion of Photocarriers to Improve the Spatial Resolution of the Chemical Imaging Sensor International-presentation

    T. Suto, K. Miyamoto, C. F. Werner, T. Wagner, M. J. Schöning, T. Yoshinobu

    Eurosensors 2017　2017/09/05

  40. Lateral Resolution of a Light-addressable Sensor with Regard to Modulation Frequency and Light Intensity International-presentation

    C. F. Werner, K. Miyamoto, T. Wagner, M. J. Schöning, T. Yoshinobu

    Engineering of Functional Interfaces 2017 (EnFI2017)　2017/08/28

  41. A Partially Etched Structure of Light-addressable Potentiometric Sensor for High-resolution and High-speed Chemical Imaging International-presentation

    H. A. Truong, C. F. Werner, K. Miyamoto, T. Yoshinobu

    Engineering of Functional Interfaces 2017 (EnFI2017)　2017/08/28

  42. (Poster Spotlight) 3D-Printed Microfluidic Channel and Cultivation Mold for Quantitative Evaluation of Cell Migration Property

    K. Miyamoto, T. Wagner, M. J. Schöning, T. Yoshinobu

    25th ESACT Meeting (European Society for Animal Cell Technology)　2017/05/14

  43. Implantable Polymer Composite Electrode with Carbon Nano Fibers (CNF) Aligned during Thermal Drawing as a Reliable Chronic Neural Interface International-presentation

    Y. Guo, S. Jiang, B. Grena, I. Kimbrough, Y. Fink, H. Sontheimer, T. Yoshinobu, X. Jia

    Materials Research Society 2017 Spring Meeting　2017/04/17

  44. Novel Flexible Neural Probes Integrated with Multi-Functionality for Probing Neural Circuits at Different Brain Regions with High Precision International-presentation

    Y. Guo, D. Hu, I. Kimbrough, A. Wang, H. Sontheimer, T. Yoshinobu, X. Jia

    Materials Research Society 2016 Fall Meeting　2016/11/27

  45. Detection of Defects in a Cell Layer by Chemical Imaging Sensor International-presentation

    K. Miyamoto, B. Yu, T. Yoshinobu

    KJF International Conference on Organic Materials for Electronics and Photonics 2016 (KJF-ICOMEP 2016)　2016/09/04

  46. Lateral Resolution Enhancement of Pulse-Driven Light-Addressable Potentiometric Sensor International-presentation

    C. F. Werner, T. Wagner, M. J. Schöning, T. Yoshinobu

    The 16th International Meeting on Chemical Sensors (IMCS 2016)　2016/07/10

  47. A High-Q LC Resonance Circuit for the Readout of an EIS Capacitive Sensor International-presentation

    K. Miyamoto, K. Hayashi, C. F. Werner, T. Wagner, M. J. Schöning, T. Yoshinobu

    The 16th International Meeting on Chemical Sensors (IMCS 2016)　2016/07/10

  48. A Bubble-Assisted Electroosmotic Micropump for a Delivery of a Droplet in a Microfluidic Channel Combined with a Light-Addressable Potentiometric Sensor International-presentation

    X. Li, S. Liu, J. Liang, C. F. Werner, K. Miyamoto, T. Yoshinobu

    The 16th International Meeting on Chemical Sensors (IMCS 2016)　2016/07/10

  49. Pulse-based Light-addressable Potentiometric Sensor for Bio/Chemical Probing Station International-presentation

    C. F. Werner, K. Miyamoto, T. Wagner, M. J. Schöning, T. Yoshinobu

    9th Meeting of Engineering of Functional Interfaces (EnFI 2016)　2016/07/03

  50. (Best Poster Award) In vivo Label-Free Microscopy Device Based on Field-Effect Sensor and Polymer Fibers for Deep Brain Imaging International-presentation

    Y. Guo, X. Jia, P. Anikeeva, T. Yoshinobu

    Materials Research Society 2015 Fall Meeting　2015/11/29

  51. Visualization of Defects on a Cultured Cell Layer by Utilizing Chemical Imaging Sensor International-presentation

    K. Miyamoto, B. Yu, T. Wagner, T. Yoshinobu, M. J. Schöning

    Eurosensors XXIX　2015/09/06

  52. From the Light‐Addressable Potentiometric Sensor towards a Fully Integrated (Bio)chemical Sensor Platform International-presentation

    T. Wagner, C. F. Werner, K. Miyamoto, T. Yoshinobu, M. J. Schöning

    4th International Symposium on Sensor Science (I3S2015)　2015/07/13

  53. Application of Electroosmotic Micropumps to a Microfluidic System Combined with a Light-addressable Potentiometric Sensor International-presentation

    X. L. Li, S. B. Liu, J. T. Liang, K. Miyamoto, T. Yoshinobu

    Engineering of Functional Interfaces 2015 (EnFI 2015)　2015/07/06

  54. LAPS-based Optoelectronic Device for Mapping the Brain Activities in vivo International-presentation

    Y. Guo, X. Jia, A. Canales, U. P. Froriep, K. Miyamoto, P. Anikeeva, T. Yoshinobu

    Engineering of Functional Interfaces 2015 (EnFI 2015)　2015/07/06

  55. Rapid Prototyping of Microfluidic Devices for On-chip Cell Assay Combined with a Chemical Imaging Sensor International-presentation

    K. Miyamoto, T. Wagner, T. Yoshinobu, M. J. Schöning

    Engineering of Functional Interfaces 2015 (EnFI 2015)　2015/07/06

  56. New LAPS Driving Method for Better Lateral Resolutions International-presentation

    C. F. Werner, T. Wagner, M. J. Schöning, T. Yoshinobu

    Engineering of Functional Interfaces 2015 (EnFI 2015)　2015/07/06

  57. Surface Treatment of 3D-printed Microfluidics for Cell-based Biosensors International-presentation

    S. Takenaga, B. Schneider, E. Erbay, T. Schnitzler, K. Miyamoto, T. Yoshinobu, M. Biselli, M. J. Schöning, T. Wagner

    10th International Symposium on Electrochemical Micro & Nanosystem Technologies (EMNT 2014)　2014/11/05

  58. Highly Flexible and Portable Electrochemical Imaging Station International-presentation

    C. F. Werner, T. Yoshinobu, K. Miyamoto, M. J. Schöning, T. Wagner

    10th International Symposium on Electrochemical Micro & Nanosystem Technologies (EMNT 2014)　2014/11/05

  59. Real-time pH Imaging System Based on the Light-addressable Potentiometric Sensor International-presentation

    T. Yoshinobu, K. Miyamoto, K. Kurosu, C. F. Werner, T. Wagner, M. J. Schöning

    10th International Symposium on Electrochemical Micro & Nanosystem Technologies (EMNT 2014)　2014/11/05

  60. In situ Observation of pH Change on the Metal Surface Caused by Electrolysis Corrosion International-presentation

    S. Sakakita, K. Miyamoto, T. Yoshinobu

    10th International Symposium on Electrochemical Micro & Nanosystem Technologies (EMNT 2014)　2014/11/05

  61. Detection of Enzymatic Reaction by Capacitive EIS Sensor with a Bridge Circuit International-presentation

    A. Kato, K. Miyamoto, dT. Yoshinobu

    10th International Symposium on Electrochemical Micro & Nanosystem Technologies (EMNT 2014)　2014/11/05

  62. Enhancement of the Spatial Resolution of the Chemical Imaging Sensor by a Hybrid Fiber-Optic Illumination International-presentation

    K. Miyamoto, K. Seki, Y. Guo, T. Wagner, M. J. Schöning, T. Yoshinobu

    Eurosensors 2014,　2014/09/07

  63. Device Simulation of the Light-Addressable Potentiometric Sensor with a Novel Photoexcitation Method for a Higher Spatial Resolution

    Y. Guo, K. Seki, K. Miyamoto, T. Wagner, M. J. Schöning, T. Yoshinobu

    Eurosensors 2014　2014/09/07

  64. Development of Embedded Light-addressable Potentiometric Sensor Devices International-presentation

    C. F. Werner, N. Tobies, P. Schulze-Schwering, T. Yoshinobu, M. J. Schöning, T. Wagner

    Engineering of Functional Interfaces Workshop 2014 (EnFI2014)　2014/07/14

  65. Microfluidic-based Light-addressable Potentiometric Sensor (LAPS) for the Detection of Metabolic Activity by Differential Measurements International-presentation

    S. Takenaga, Th. Schnitzler, T. Yoshinobu, M. Biselli, M. J. Schöning, T. Wagner

    Engineering of Functional Interfaces Workshop 2014 (EnFI2014)　2014/07/14

  66. Visualization of the Barrier Function of Small Intestine Model Using Chemical Imaging Sensor International-presentation

    K. Miyamoto, Y. Bing, J. Han, H. Isoda, T. Yoshinobu

    Engineering of Functional Interfaces Workshop 2014 (EnFI2014)　2014/07/14

  67. OLED-based and Embedded Sensor Platform for Chemical Imaging International-presentation

    C. F. Werner, T. Yoshinobu, K. Miyamoto, M. J. Schöning, T. Wagner

    The 15th International Meeting on Chemical Sensors (IMCS 2014)　2014/03/16

  68. Light-Addressable Potentiometric Sensor as Sensing Element in Plug-Based Microfluidic Devices International-presentation

    K. Miyamoto, T. Sato, T. Wagner, M. J. Schöning, T. Yoshinobu

    The 15th International Meeting on Chemical Sensors (IMCS 2014)　2014/03/16

  69. Device-level Simulation of the Light-addressable Potentiometric Sensor for High-speed and High-resolution Chemical Imaging International-presentation

    Y. Guo, K. Miyamoto, T. Wagner, M.J. Schöning, T. Yoshinobu

    2013 International Conference on Solid State Devices and Materials (SSDM 2013)　2013/09/24

  70. (Best Presentation Award) Theoretical Study and Simulation of Light-Addressable Potentiometric Sensors International-presentation

    Y. Guo, K. Miyamoto, T. Wagner, M. J. Schöning, T. Yoshinobu

    Engineering of Functional Interfaces Workshop 2013 (EnFI2013)　2013/07/08

  71. High-Speed Chemical Imaging Inside a Microfluidic Channel International-presentation

    A. Itabashi, K. Miyamoto, T. Wagner, M.J. Scöning, T. Yoshinobu

    The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2013) & Eurosensors XXVII　2013/06/16

  72. Development of the system for multi-channel TER measurement International-presentation

    K. Miyamoto, J. Han, T. Yoshinobu, H. Isoda

    The 25th Annual and International Meeting of the Japanese Association for Animal Cell Technology (JAACT2012)　2012/11/27

  73. High-Resolution and High-Speed Chemical Imaging Sensor Based on Optical Fiber Array International-presentation

    K. Miyamoto, N. Kosaka, T. Wagner, T. Yoshinobu

    2012 International Conference on Solid State Devices and Materials (SSDM 2012)　2012/09/25

  74. Chemical Imaging of Ion Diffusion in a Microfluidic Channel International-presentation

    K. Miyamoto, H. Ichimura, T. Wagner, T. Yoshinobu, M. J. Schöning

    Eurosensors XXVI　2012/09/09

  75. Light-Addressable Potentiometric Sensor and Light-Addressable Electrodes as a Combined Sensor-and-Manipulator Microsystem with High Flexibility International-presentation

    T. Wagner, N. Shigihara, K. Miyamoto, J. Suzurikawa, F. Finger, M. J. Schöning, T. Yoshinobu

    Eurosensors XXVI　2012/09/09

  76. A Novel Flexible Chemical Imaging Set-Up of Amorphous- Si-Based Light-Addressable Potentiometric Sensor by Video Projector International-presentation

    A. Das, Y.-H. Lin, T. Yoshinobu, C.-S. Lai

    The 14th International Meeting on Chemical Sensors (IMCS 2012)　2012/05/20

  77. High-Speed Chemical Imaging System Based on Front-Side-Illuminated LAPS International-presentation

    A. Itabashi, N. Kosaka, K. Miyamoto, T. Wagner, T. Yohsinobu

    The 14th International Meeting on Chemical Sensors (IMCS 2012)　2012/05/20

  78. High Speed and High Resolution Chemical Imaging Based on a New Type of OLED-LAPS Set-Up International-presentation

    C. F. Werner, T. Wagner, K. Miyamoto, T. Yoshinobu, M. J. Schöning

    Eurosensors XXV　2011/09/05

  79. Microfluidic Systems with Free Definable Sensor Spots by an Integrated Light-Addressable Potentiometric Sensor International-presentation

    T. Wagner, K. Miyamoto, N. Shigihara, M. J. Schöning, T. Yoshinobu

    Eurosensors XXV　2011/09/05

  80. Determination of Glucose Concentration by Means of a Microorganism-Based Biosensor International-presentation

    C. F. Werner, S. Groebel, T. Wagner, T. Selmer, T. Yoshinobu, M. E. M. Baumann, M. Keusgen, M. J. Schöning

    Engineering of Functional Interfaces Workshop 2011 (EnFI2011)　2011/07/19

  81. Light-Addressable Potentiometric Sensor System Based on a Single-Chip Controller Unit International-presentation

    T. Wagner, K. Miyamoto, T. Kaga, F. Werner, M.J. Schöning, T. Yoshinobu

    Engineering of Functional Interfaces Workshop 2011 (EnFI2011)　2011/07/19

  82. Multi-Well Structure for Cell Culture on the Chemical Imaging Sensor International-presentation

    K. Miyamoto, T. Wagner, M. J. Schöning, T. Yoshinobu

    The 16th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers'11)　2011/06/05

  83. Flexible Electrochemical Imaging by Light-Addressable Potentiometric Sensor with 'Zoom-in' Functionality International-presentation

    T. Wagner, K. Miyamoto, C. F. Werner, M. J. Schöning, T. Yoshinobu

    The 16th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers'11)　2011/06/05

  84. Differential Setup of Light-Addressable Potentiometric Sensor with an Enzyme Reactor International-presentation

    K. Miyamoto, M. Yoshida, T. Wagner, T. Yoshinobu, M. J. Schöning

    2010 International Conference on Solid State Devices and Materials (SSDM 2010)　2010/09/22

  85. Miniaturized Chemical Imaging Sensor System Using an OLED Display Panel International-presentation

    K. Miyamoto, K. Kaneko, A. Matsuo, T. Wagner, M. J. Schöning, T. Yoshinobu

    Eurosensors XXIV　2010/09/05

  86. Novel Combination of Digital Light Processing (DLP) and Light-Addressable Potentiometric Sensors (LAPS) for Flexible Chemical Imaging International-presentation

    T. Wagner, K. Miyamoto, M. J. Schöning, T. Yoshinobu

    Eurosensors XXIV　2010/09/05

  87. (Invited Talk) Chemical Imaging Sensor and its Applications Invited

    T. Yoshinobu

    Engineering of Functional Interfaces Workshop (EnFI2010)

  88. Differential Set-Up for Detecting Local Changes of Ion Concentration Using a Single Sensor Chip International-presentation

    T. Wagner, K. Miyamoto, M. J. Schöning, T. Yoshinobu

    Engineering of Functional Interfaces Workshop (EnFI2010)　2010/07/15

  89. On-Line Determination of the Condition of Microorganisms by a Light-Addressable Potentiometric Sensor International-presentation

    C. F. Werner, S. Groebel, H. Spelthahn, T. Wagner, T. Yoshinobu, T. Selmer, M. Keusgen, M. J. Schöning

    Engineering of Functional Interfaces Workshop (EnFI2010)　2010/07/15

  90. Phase-Mode Operation of FDM-LAPS International-presentation

    K. Miyamoto, T. Sakai, T. Wagner, S. Kanoh, T. Yoshinobu, M. J. Schöning

    The 13th International Meeting on Chemical Sensors　2010/07/11

  91. Utilising Digital Micro Mirror Device (DMD) as Scanning Light Source for Light-Addressable Potentiometric Sensors (LAPS) International-presentation

    T. Wagner, K. Miyamoto, C. F. Werner, M. J. Schöning, T. Yoshinobu

    The 13th International Meeting on Chemical Sensors　2010/07/11

  92. Miniaturized and High-Speed Chemical / Bio-Imaging System International-presentation

    T. Yoshinobu

    4th IEEE International NanoElectronics Conference (INEC2011)　2010/06/21

  93. Real-Time Correction of Biosensor Signals by Combination of EIS Sensor and LAPS into a Single Sensor Structure International-presentation

    T Wagner, C.F. Werner, K Miyamoto, M. J. Schöning, T Yoshinobu

    20th Anniversary World Congress on Biosensors　2010/05/26

  94. Multi-Point Measurement in a Fluidic Channel for the Sensing of Urea Concentration International-presentation

    T. Sakai, M. Yoshida, K. Miyamoto, T. Wagner, S. Kanoh, T. Yoshinobu

    5th International Sympotium on Medical, Bio- and Nano-Electronics　2010/02/24

  95. Miniaturized Chemical Imaging Sensor System Using a Display Panel as a Light Source International-presentation

    K. Kaneko, A. Matsuo, K. Miyamoto, T. Wagner, S. Kanoh, T. Yoshinobu

    5th International Sympotium on Medical, Bio- and Nano-Electronics　2010/02/24

  96. The Effect of Feedback Training on Brain Activation during Motor Imagery: a NIRS Study International-presentation

    K. Iizuka, S. Kanoh, K. Miyamoto, T. Yoshinobu, R. Kawashima

    5th International Sympotium on Medical, Bio- and Nano-Electronics　2010/02/24

  97. A High-Density Multi-Point Laps Set-Up Using a VCSEL Array and FPGA Control International-presentation

    T. Wagner, C. F. Werner, K. Miyamoto, M. J. Schöning, T. Yoshinobu

    Eurosensors XXIII　2009/09/06

  98. Constant-Phase-Mode Operation of the Light-Addressable Potentiometric Sensor International-presentation

    K. Miyamoto, T. Wagner, S. Mimura, S. Kanoh, T. Yoshinobu, M. J. Schöning

    Eurosensors XXIII　2009/09/06

  99. A NIRS-Based Brain-Computer Interface System during Motor Imagery: System Development and Online Feedback Training International-presentation

    S. Kanoh, Y. Murayama, K. Miyamoto, T. Yoshinobu, R. Kawashima

    31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2009)　2009/09/02

  100. A Brain-Computer Interface Based on Auditory Stream Segregation International-presentation

    S. Kanoh, K. Miyamoto, T. Yoshinobu

    2009 IEEE 11th International Conference on Rehabilitation Robotics (ICORR2009)　2009/06/23

  101. Phase-Mode LAPS and its Application to Chemical Imaging International-presentation

    K. Miyamoto, T. Wagner, T. Yoshinobu, S. Kanoh, M. J. Schöning

    15th Int. Conf. on Solid-State Sensors, Actuators & Microsystems (Transducers2009)　2009/06/21

  102. FPGA-based LAPS Device for the Flexible Design of Sensing Sites on Functional Interfaces International-presentation

    T. Wagner, C. F. Werner, K. Miyamoto, H.-J. Ackerman, T. Yoshinobu, M. J. Schöning

    Engineering of Functional Interfaces Workshop (EnFI 2009)　2009/06/18

  103. A Brain-Computer Interface (BCI) System Using Selective Attention to Auditory Streams International-presentation

    S. Kanoh, K. Miyamoto, T. Yoshinobu

    Forth Asian Pacific Conference on Biomechanics (APAB2009)　2009/04/14

  104. Image Correction for the Chemical Imaging Sensor International-presentation

    9th International Symposium of Tohoku University Global COE Programme　2009/03/27

  105. Cell culture based biosensor utilising the light-addressable potentiometric sensor (LAPS) International-presentation

    T. Wagner, W. Vornholt, C. F. Werner, K. Miyamoto, M. Keusgen, T. Yoshinobu, M. J. Schöning

    4th International Sympotium on Medical, Bio- and Nano-Electronics　2009/03/05

  106. Extraction methods of motor imagery-related features for EEG-based BCI system International-presentation

    I Putu Susila, S. Kanoh, K. Miyamoto, T. Yoshinobu

    4th International Sympotium on Medical, Bio- and Nano-Electronics　2009/03/05

  107. A brain-computer interface (BCI) system to detect motor imagery by NIRS International-presentation

    Y. Murayama, S. Kanoh, K. Miyamoto, T. Yoshinobu, R. Kawashima

    4th International Sympotium on Medical, Bio- and Nano-Electronics　2009/03/05

  108. ICA-based feature extraction from multi-channel EEG signal for brain-computer interface (BCI) International-presentation

    I. Asanuma, S. Kanoh, K. Miyamoto, T. Yoshinobu

    4th International Sympotium on Medical, Bio- and Nano-Electronics　2009/03/05

  109. New FPGA-based LAPS driver for simultaneous operation of a large number of measurement spots International-presentation

    T. Wagner, C. F. Werner, K. Miyamoto, H.-J. Ackermann, T. Yoshinobu, M. J. Schöning

    4th International Sympotium on Medical, Bio- and Nano-Electronics　2009/03/05

  110. Image calibration to compensate for the nonuniformity of a chemical image sensor plate International-presentation

    Y. Sugawara, K. Miyamoto, S. Kanoh, T. Yoshinobu, T. Wagner, M. J. Schöning

    4th International Sympotium on Medical, Bio- and Nano-Electronics　2009/03/05

  111. Multi-point LAPS system for differential measurement of enzyme reaction International-presentation

    M. Yoshida, T. Wagner, K. Miyamoto, S. Kanoh, T. Yoshinobu, M. J. Schöning

    4th International Sympotium on Medical, Bio- and Nano-Electronics　2009/03/05

  112. Development of Brain-Computer Interface (BCI) System for Bridging Brain and Computer International-presentation

    S. Kanoh, K. Miyamoto, T. Yoshinobu

    13th International Conference on Biomedical Engineering (ICBME 2008)　2008/12/03

  113. Measurement of Brain Activities and its Application to Brain-Computer Interface (BCI) International-presentation

    S. Kanoh, K. Miyamoto, T. Yoshinobu

    International Symposium on Nano-Biomedical Engineering　2008/10/19

  114. Effects of Long-Term Feedback Training on Oscillatory EEG Components Modulated by Motor Imagery International-presentation

    S. Kanoh, R. Scherer, T. Yoshinobu, N. Hoshimiya, G. Pfurtscheller

    4th International Brain-Computer Interface Workshop and Training Course 2008　2008/09/18

  115. The "xBCI" Platform: Development and Application to On-Line BCI System International-presentation

    I Putu Susila, S. Kanoh, K. Miyamoto, T. Yoshinobu

    Joint 4th International Conference on Soft Computing and Intelligent Systems and 9th International Symposium on Advanced Intelligent Systems (SCIS & ISIS 2008)　2008/09/17

  116. Image Correction Method for the Chemical Imaging Sensor International-presentation

    Y. Sugawara, K. Miyamoto, S. Kanoh, T. Yoshinobu, T. Wagner, M. J. Schöning

    Eurosensors XXII 2008　2008/09/07

  117. A Brain-Computer Interface (BCI) System Based on Auditory Stream Segregation International-presentation

    Shin'ichiro Kanoh, Ko-ichiro Miyamoto, Tatsuo Yoshinobu

    IEEE Engineering in Medicine and Biology Conference (EMBC) 2008　2008/08/20

  118. Chemical Image Scanner Based on FDM-LAPS International-presentation

    Y. Kuwabara, K. Miyamoto, S. Kanoh, T. Yoshinobu, T. Wagner, M. J. Schöning

    12th International Meeting on Chemical Sensors (IMCS12)　2008/07/13

  119. Parallel Scanning System for the Chemical Imaging Sensor International-presentation

    5th International Symposium of 2007 Tohoku University Global COE Programme　2008/03/27

  120. Brain-Computer Intarface (BCI) : Bridging Brain and Computer International-presentation

    S. Kanoh, K. Miyamoto, T. Yoshinobu

    3rd International Symposium on Medical, Bio- and Nano-Electronics　2008/03/05

  121. Fast Scan of Chemical Images Based on Multi-Light LAPS International-presentation

    Y. Kuwabara, K. Miyamoto, S. Kanoh, T. Yoshinobu

    3rd International Symposium on Medical, Bio- and Nano-Electronics　2008/03/05

  122. Multi-Point LAPS Measurement in Flow Channels International-presentation

    A. Matsuzaka, K. Miyamoto, S. Kanoh, T. Yoshinobu

    3rd International Symposium on Medical, Bio- and Nano-Electronics　2008/03/05

  123. Application of EIS Capacitive Sensor to Micro Channels International-presentation

    K. Morihiro, K. Miyamoto, S. Kanoh, T. Yoshinobu

    3rd International Symposium on Medical, Bio- and Nano-Electronics　2008/03/05

  124. Light-Addressable Potentiometric Sensor (LAPS) Platform for Biotechnological Processes International-presentation

    T. Wagner, M. E. M. Baumann, S. Grobel, M. Biselli, T. Yoshinobu, M. J. Schöning

    3rd International Symposium on Medical, Bio- and Nano-Electronics　2008/03/05

  125. A BCI System Using Event-Related Potentials with Auditory Stream Segregation International-presentation

    T. Yamagishi, S. Kanoh, K. Miyamoto, T. Yoshinobu

    3rd International Symposium on Medical, Bio- and Nano-Electronics　2008/03/05

  126. Effect of Feedback Training on EEG-Based BCI System to Detect Motor Imagery International-presentation

    M. Takahashi, S. Kanoh, R. Scherer, T. Yoshinobu, N. Hoshimiya, G. Pfurtscheller

    3rd International Symposium on Medical, Bio- and Nano-Electronics　2008/03/05

  127. Rapid Prototyping of an EEG-Based Online BCI System: Development of a Generic Platform International-presentation

    I Putu Susila, S. Kanoh, K. Miyamoto, T. Yoshinobu

    3rd International Symposium on Medical, Bio- and Nano-Electronics　2008/03/05

  128. A Light-Addressable Potentiometric Sensor System for Fast, Simultaneous and Spatial Detection of the Metabolic Activity of Biological Cells International-presentation

    T. Wagner, R. Molina, M. Biselli, M. Canzoneri, T. Schnitzler, T. Yoshinobu, M. J. Schöning

    The 14th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers '07) & Eurosensors XXI　2007/06/10

  129. Brain Switch' BCI System Based on EEG during Foot Movement Imagery International-presentation

    S. Kanoh, R. Scherer, T. Yoshinobu, N. Hoshimiya, Gert Pfurtscheller

    3rd International BCI Workshop 2006　2006/09/21

  130. Positive Patterning of Ferritin Molecules on Silicon by Atomic Force Microscopy Anodic Oxidation International-presentation

    K. Shanmugam, T. Yoshinobu, H. Iwasaki

    Sanken International Symposium on Nanoscience and Nanotechnology 2006 - Perspective on Interdisciplinary Nanobiology and Industrial Nanotechnology -　2006/09/19

  131. Handheld Multi-Channel LAPS Device as a Transducer Platform for Possible Biological Applications International-presentation

    T. Wagner, R. Molina, T. Yoshinobu, R. Otto, M. J. Schöning

    The Sixth International Symposium on Electrochemical Micro & Nanosystem Technologies (EMNT2006)　2006/08/22

  132. Positive Patterning of Ferritin and Fibronectin Molecules on Silicon International-presentation

    K. Shanmugam, T. Yoshinobu, H. Iwasaki

    Scanning Probe Microscopy, Sensors and Nanostructures　2006/06/03

  133. (Invited Talk) Application of Thin-Film Amorphous Silicon to Chemical Imaging International-presentation Invited

    T. Yoshinobu, W. Moritz, F. Finger, M. J. Schöning

    Materials Research Society 2006 Spring Meeting　2006/04/17

  134. Licht-adressierbare potentiometrische Sensorsysteme - Konzepte und Anwendungen International-presentation

    T. Wagner, T. Yoshinobu, R. Otto, S. Wang, C. Rao, R. Molina, M.J. Schöning

    Sensoren und Messsysteme 2006　2006/03/13

  135. Chemical Imaging by the Light-Addressable Potentiometric Sensor International-presentation

    S. Ito, T. Kinefuchi, A. Matsuzaka, S. Kanoh, T. Yoshinobu

    International Symposium on Bio- and Nano-Electronics in Sendai　2006/03/02

  136. Chipkarten-basierter Multikanal lichtadressierbarer potentiometrische Sensor für analytische Untersuchungen in flüssigen Medien International-presentation

    T. Wagner, C.-W. Rao, R. Otto, T. Yoshinobu, J. P. Klook, M. J. Schöning

    7. Dresdner Sensor-Symposium, Neue Herausforderungen und Anwendungen in der Sensortechnik　2005/12/12

  137. Thin-Film Sensors with Chalcogenide Glass Materials - a General Survey International-presentation

    J. P. Kook, J. Schubert, Y. Ermolenko, Y. G. Vlasov, T. Yoshinobu, A. Bratov, M. J. Schöning

    84th ICB Seminar on Biochemical Sensing - Utilisation of Micro- and Nanotechnologies　2005/11/23

  138. Multi-Parameter Sensing of Both Physical and (Bio-)Chemical Quantities Using the Same Transducer Principle International-presentation

    N. Näther, A. Poghossian, J. Platen, T. Yoshinobu, M. Koudelka-Hep, M. J. Schöning

    84th ICB Seminar on Biochemical Sensing - Utilisation of Micro- and Nanotechnologies　2005/11/23

  139. PLD-Prepared Cadmium Sensors Based on Chalcogenide Glasses - ISFET, LAPS and μISE Semiconductor Structures International-presentation

    J. P. Kloock, L. Moreno, A. Bratov, T. Wagner, T. Yoshinobu, Y. Ermolenko, Y. G. Vlasov, M.J. Schöning

    Eurosensors XIX　2005/09/11

  140. LAPS Card - a Novel Chip Card-Based Light-Addressable Potentiometric Sensor (LAPS) International-presentation

    T. Wagner, C. Rao, J. P. Kloock, T. Yoshinobu, R. Otto, M.J. Schöning

    Eurosensors XIX　2005/09/11

  141. First Step Towards Parallel Real-Time Measurements for a Solid-State LAPS Device Based on FFT Algorithm International-presentation

    T. Wagner, R. Molina, C. Rao, R. Otto, T. Yoshinobu, M. J. Schöning

    The 3rd International Symposium on Sensor Science (I3S2005)　2005/07/18

  142. Development of the Chemical Imaging Sensor and its Application to Microfluidic Channels International-presentation

    T. Yoshinobu, H. Iwasaki, M. J. Schöning

    The 3rd International Symposium on Sensor Science (I3S2005)　2005/07/18

  143. All-in-one' Solid-State Device Based on a Light-addressable Potentiometric Sensor Platform International-presentation

    T. Wagner, T. Yoshinobu, R. Otto, M. J. Schöning

    The 13th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers '05)　2005/06/05

  144. Plasmon-Enhanced Molecular Fluorescence by Using a STM International-presentation

    H. W. Liu, R. Nishitani, Y. Ie, M. Nowicki, T. Yoshinobu, K. Sudoh, Y. Aso, H. Iwasaki

    Scanning Probe Microscopy, Sensors & Nanostructures　2005/06/05

  145. Positive Patterning of Ferritin Molecules on Silicon International-presentation

    K. Shanmugam, T. Yoshinobu, H. Iwasaki

    Scanning Probe Microscopy, Sensors & Nanostructures　2005/06/05

  146. Positive Patterning of Ferritin Molecules on Silicon International-presentation

    K. Shanmugam, S. Iida, T. Yoshinobu, H. Iwasaki

    Third 21st Century COE "Towards Creating New Industries Based on Inter-Nanoscience" International Symposium (ISCOE-2005)　2005/03/09

  147. Study of Porphyrin Molecules Adsorbed on Conductive Substrates by STL International-presentation

    H. W. Liu, R. Nishitani, Y. Ie, T. Yoshinobu, Y. Aso, H. Iwasaki

    Third 21st Century COE "Towards Creating New Industries Based on Inter-Nanoscience" International Symposium (ISCOE-2005)　2005/03/09

  148. AFM Micropatterning of Biomolecules on Silicon International-presentation

    T. Yoshinobu

    Molecule-Based Information Transmission and Reception - Application of Membrane Protein Biofunction - (MB-ITR2005)　2005/03/03

  149. STM-Excited Luminescence from Organic Materials on Au(111) International-presentation

    H. W. Liu, R. Nishitani, Y. Ie, T. Yoshinobu, Y. Aso, H. Iwasaki

    SANKEN International Symposium on Scientific and Industrial Nanotechnology - Advanced Characterization for Nanomaterials, Nanodevices and Nanoprocessing (8th SANKEN International Symposium & 3rd International Symposium on Scientific and Industrial Nanotec　2004/12/06

  150. Micropatterning of Protein and DNA Molecules on Si by AFM International-presentation

    T. Yoshinobu, W. C. Moon, J. Suzuki, A. Nishikawa, H. Iwasaki

    SANKEN International Symposium on Scientific and Industrial Nanotechnology - Advanced Characterization for Nanomaterials, Nanodevices and Nanoprocessing (8th SANKEN International Symposium & 3rd International Symposium on Scientific and Industrial Nanotec　2004/12/06

  151. Portable Multi-Sensor LAPS (Light-Addressable Potentiometric Sensor) for Ion Sensing International-presentation

    T. Wagner, R. Otto, H. Iwasaki, T. Yoshinobu, M.J. Schöning

    Shanghai International Conference on Physiological Biophysics (Shanghai ICPB'04)　2004/11/09

  152. AFM Micropatterning of Protein and DNA Molecules on Si International-presentation

    T. Yoshinobu, W.-C. Moon, A. Nishikawa, J. Suzuki, H. Iwasaki

    Shanghai International Conference on Physiological Biophysics (Shanghai ICPB'04)　2004/11/09

  153. STM-Excited Fluorescence from Organic Films International-presentation

    H. W. Liu, R. Nishitani, T. Yoshinobu, H. Iwasaki, T. Matsumura-Inoue

    Korea Japan Joint Forum 2004 "Organic Materials for Electronics and Photonics"　2004/11/03

  154. Patterning of Biomolecules on Silicon by AFM Oxidation International-presentation

    T. Yoshinobu, W. C. Moon, A. Nishikawa, J. Suzuki, H. Iwasaki

    2004 International Microprocesses and Nanotechnology Conference (MNC 2004)　2004/10/26

  155. Micropatterning of Biomolecules on Si by AFM Anodic Oxidation Technique International-presentation

    T. Yoshinobu, H. Iwasaki

    International Workshop on Surface-Biotronics　2004/10/19

  156. Scanning Photo-Induced Impedance Microscopy - Improvements in Lateral Resolution International-presentation

    W. Moritz, T. Yoshinobu, F. Finger, S. Krause, M. J. Schöning

    2004 Joint International Meeting: 206th Meeting of The Electrochemical Society, Inc. & 2004 Fall Meeting of The Electrochemical Society of Japan　2004/10/03

  157. Immobilization of DNA on Arrayed SiO2 Dots Prepared by AFM Anodic Oxidation International-presentation

    T. Yoshinobu, W. Moon, A. Nishikawa, H. Iwasaki

    5th International Symposium on Electrochemical Micro & Nanosystem Technologies (EMT2004)　2004/09/28

  158. Application of the Light-Addressable Potentiometric Sensor to Chemical Imaging of a Microfluidic Channel International-presentation

    T. Yoshinobu, Y. Ui, H. Iwasaki, N. Näther, M. J. Schöning, M. Koudelka-Hep

    5th International Symposium on Electrochemical Micro & Nanosystem Technologies (EMT2004)　2004/09/28

  159. A Handheld 16 Channel Pen-Type LAPS as a Platform for (Bio-)Electrochemical Sensing International-presentation

    T. Wagner, M. J. Schöning, R. Otto and, T. Yoshinobu

    International Symposium on Cellular Engineering and Nanosensors (part of the 38th Annual Congress on Biomedical Engineering)　2004/09/21

  160. Potentiometric Imaging in a Microfluidic Channel International-presentation

    T. Yoshinobu, Y. Ui, H. Iwasaki, N. Näther, M. Koudelka-Hep, M. J. Schöning

    International Symposium on Cellular Engineering and Nanosensors (part of the 38th Annual Congress on Biomedical Engineering)　2004/09/21

  161. Microscopy of Impedance and Surface Ion Concentrations International-presentation

    W. Moritz, T. Yoshinobu, F. Finger, S. Krause, M. Xu, M. J. Schöning

    International Symposium on Cellular Engineering and Nanosensors (part of the 38th Annual Congress on Biomedical Engineering)　2004/09/21

  162. Micropatterning of Biomolecules on Silicon by AFM Anodic Oxidation International-presentation

    T. Yoshinobu, W. Moon, A. Nishikawa, J. Suzuki, H. Iwasaki

    International Symposium on Cellular Engineering and Nanosensors (part of the 38th Annual Congress on Biomedical Engineering)　2004/09/21

  163. Application of the Light-Addressable Potentiometric Sensor to Microfluidic Devices International-presentation

    T. Yoshinobu, Y. Ui, H. Iwasaki, N. Näther, M. J. Schöning, M. Koudelka-Hep

    Eurosensors XVIII (18th European Conference on Solid-State Transducers)　2004/09/13

  164. Development of a Handheld 16 Channel Pen-Type LAPS for Electrochemical Sensing International-presentation

    M. J. Schöning, C. Wang, R. Otto, T. Yoshinobu

    The 10th International Meeting on Chemical Sensors (10-IMCS)　2004/07/11

  165. AFM Patterning and Immobilization of Biomolecules on Si International-presentation

    W.-C. Moon, T. Yoshinobu, A. Nishikawa, H. Iwasaki

    The 10th International Meeting on Chemical Sensors (10-IMCS)　2004/07/11

  166. Immobilization of Urease and Cholinesterase on the Surface of Semiconductor Transducer for the Development of Light-Addressable Potentiometric Sensors International-presentation

    I. G. Mourzina, T. Yoshinobu, Yu. E. Ermolenko, Yu. G. Vlasov, M. J. Schöning, H. Iwasaki

    The 10th International Meeting on Chemical Sensors (10-IMCS)　2004/07/11

  167. Fabrication of Thin-Film LAPS with Amorphous Silicon International-presentation

    T. Yoshinobu, M. J. Schöning, F. Finger, W. Moritz, H. Iwasaki

    The 2nd International Symposium on Sensor Science　2004/05/29

  168. Towards a Portable Multi-Sensor LAPS Unit with Integrated Signal Processing International-presentation

    T. Wagner, C. Wang, R. Otto, J. P. Kloock, T. Yoshinobu, M. J. Schöning

    The 2nd International Symposium on Sensor Science　2004/05/29

  169. Surface Morphological Evolution During Protein Crystal Growth from Solutions International-presentation

    K. Kimura, T. Yoshinobu, K. Sudoh, H. Iwasaki

    2004 Scanning Probe Microscopy, Sensors and Nanostructures　2004/05/23

Show all Show first 5

Research Projects 21

  1. 化学イメージセンサのマルチアナライト化による反応可視化汎用プラットフォームの実現

    吉信 達夫, 宮本 浩一郎, WERNER Frederik, 郭 媛元

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2022/04/01 - 2026/03/31

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    本研究は、1枚のセンサで複数の種類のイオンや分子の濃度分布を同時に画像化できる「マルチアナライト化学イメージセンサ」の実現を目的としている。従来、1枚のセンサで測定できる化学種は1つに限られていたたが、本研究では測定したい各化学種に応答する複数の感応膜を1枚のセンサ面上に集積する方法と、それらの応答を高速かつ正確に読み出す機構を開発することによって、目的の達成を目指している。 本年度は昨年度に引き続き、各種イオノフォアを含有する高分子膜をセンサ面上に作製し、感度や測定限界の違いを調べた。センサ面とイオン感応膜の密着性や、得られるスロープ感度の再現性に課題があったが、センサ面と各感応膜の間に画素の大きさに対応する導電性の下地層を設けることによりこれらの課題を解決できる見込みを得た。また、光走査によって多数の感応膜から正確に信号を読み出すための機構についても、昨年度に引き続き改良を進め、100万画素の画像を読み出せるようになった。 実用上問題になると思われる、試料溶液と半導体基板との容量結合による信号電流のロスについて、MIS構造における実験と回路モデルの解析により周波数特性などを調べ、感応膜アレイを有するセンサ構造において高周波動作を可能にする方法について検討を行った。 本システムの生物学的応用のため、センサ面上に設けた多数の培養チャンバに微生物を含む培養液を自動分注できるシステムの開発を行ったほか、植物根の生育をモニターする実験を行った。また、化学イメージセンサと各種電気化学システムを複合するための各種制御回路の開発を行った。

  2. 化学イメージセンサのマルチアナライト化による反応可視化汎用プラットフォームの実現

    吉信 達夫, 宮本 浩一郎, WERNER Frederik, 郭 媛元

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2022/04/01 - 2026/03/31

  3. Study of atmospheric corrosion of steel by hydrogen mapping and surface water analysis

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2022/04/01 - 2026/03/31

  4. Semiconductor-based chemical imaging sensor platform for realization of high-definition images of 10 megapixels

    Yoshinobu Tatsuo

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2017/04/01 - 2021/03/31

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    For realization of a high-definition chemical imaging sensor system, methods to improve the spatial resolution, to shorten the measurement time, and to use a large-area sensing plate were developed. The spatial resolution was improved by using a hybrid illumination that suppressed the lateral diffusion of photocarriers in the semiconductor layer. The measurement time was shortened by parallel readout of data using a plurality of light probes. A distributed-element model was constructed to evaluate the influence of a large-area sensing plate, and the dependence on various parameters such as the frequency, the conductivity of the solution, and the series resistance was investigated. The developed chemical imaging sensor system was applied to visualization of the corrosion process on a metal surface and the metabolism of microorganisms.

  5. 半導体デバイスを応用した分析チップ用高解像度化学イメージングシステム

    吉信 達夫, WERNER CARL FREDERIK, WERNER Carl Frederik

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 特別研究員奨励費

    Institution: 東北大学

    2014/04/25 - 2017/03/31

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    本研究では、微小流体デバイスに組み込み可能な半導体化学センサとして期待される light-addressable potentiometric sensor (LAPS)の空間分解能を向上させる新しい原理の実証と装置の開発を行った。LAPSは、画素構造や配線を形成することなく、光照射位置ごとにpHやイオン濃度の読み出しが行える光アドレス機能を有しており、1枚のセンサチップ上で複数の検体やイオンを測定したり、空間分布を画像化することができる。 LAPSは、半導体センサ裏面の光照射で発生した電子・正孔対が、センサ表面のイオン濃度に応答して形成される空乏層で電荷分離される際に生じる電流を信号として検出する。このとき、面内方向への電荷の拡散によって空間分解能が決まる。本研究では、光をパルス状に照射し、過渡電流を時間分解的に測定することによって、照射点近傍のイオン濃度を高い空間分解能で測定する方法を開発した。前年度までの研究でこの原理の実証が行えたので、最終年度はさまざまなパラメータを変化させて測定条件の最適化を行った。 実験により、パルス照射後の電流信号の積分時間に対する空間分解能の依存性を得ることができた。例として、積分時間2μsおよび10μsにおける空間分解能はそれぞれ110ミクロンおよび240ミクロンであった。積分時間を2μsより短くすることによって空間分解能をさらに向上できることが示されたが、S/N比との間にトレードオフ関係が認められた。実際にこの方法を用いて微細テストパターンのイメージングを行い、高解像度の化学イメージが得られることを確認した。また、pH感度については、従来法と本質的に同じ値を得ることができた。

  6. Development of a chemical imaging sensor for high-speed recording at 1000 fps and its application to analysis of reaction dynamics

    YOSHINOBU TATSUO, MIYAMOTO Koichiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2012/04/01 - 2016/03/31

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    In this study, the data acquisition rate of the chemical imaging sensor, which can visualize the two-dimensional distribution of pH or ion concentration in the sample placed on a semiconductor sensor plate, was enhanced to realize a movie recording of chemical species at a maximum frame rate of 1000 fps. The developed system was applied, for example, to dynamic analysis of reaction in a microfluidic channel constructed on the sensing surface and visualization of pH distribution in the vicinity of a corroding metal surface.

  7. Neurofeedback training for user adaptation to motor-imagery based BCI

    KANOH Shin'ichiro, KAWASHIMA Ryuta, YOSHINOBU Tatsuo

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku Institute of Technology

    2011 - 2013

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    The BCI (brain-computer interface) based on motor imagery is to detect the intension of subjects from their brain activities from sensorimotor cortex during imagining to move their own limbs. This study aimed to investigate the methodology to use neurofeedback training (NF), on which the processed EEG or NIRS (brain blood flow measured by near-infrared spectroscopy) data is presented to subject in real time, for improving the applicability and accuracy on motor-imagery based BCI. It was found that the motor related EEG on mu, beta and gamma band could be extracted by applying local and sparse spatial filters designed by ICA (independent component analysis) to measured EEG data, and such components could be used for neurofeedback training to improve the performance of motor-imagery based BCI.

  8. Development of EEG-based brain-computer interfaces with user adaptation capabilities

    KANOH Shin'ichiro, YOSHINOBU Tatsuo, KAWASHIMA Ryuta, HOSHIMIYA Nozumu, HANDA Yasunobu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2007 - 2009

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    The methods to improve user-applicability of BCI (brain-computer interface) using non-invasive measurements of brain activity were proposed and investigated. The methodologies of feature extraction, pattern classification and online neurofeedback were studied by EEG, NIRS (near-infrared spectroscopy) and fMRI measurements. And the BCIs based on event-related potentials (ERPs) with higher usability were proposed and evaluated.

  9. Development of a flat-bed-type chemical image scanner and its application to bioimaging

    YOSHINOBU Tatsuo, KANOH Shin'ichiro, MIYAMOTO Ko-ichiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2007 - 2009

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    In this study, a flat-bed-type chemical image scanner was developed, which was capable of visualizing the distribution of specific ions or molecules in the specimen placed on the sensing surface. In the developed system, a large-area sensor was scanned by a plurality of light sources in parallel, which resulted in great reduction of measurement time in comparison to the conventional chemical imaging sensor system. A new measurement mode was proposed, in which the ion concentration was determined by measuring the phase of the photocurrent, and its insensitivity to fluctuation of light intensity and defects in the sensor plate was demonstrated.

  10. 形態変化する分子を用いた並行計算と分散計算

    萩谷 昌己, 横山 茂之, 陶山 明, 浅沼 浩之, 藤井 輝夫, ROSE John, 村田 智, 岩崎 裕, 吉信 達夫

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 特定領域研究

    Institution: 東京大学

    2002 - 2006

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    形態変化するDNA分子の設計方法:萩谷は、連続ヘアピンからなる分子マシンに関して、ヘアピンの配列を変化させたときに、3連続ヘアピンから成る分子マシンの挙動がどのように変化するかを調べた。分子マシンの光制御を目指した光機能性超分子の構築:浅沼は、これまでとは逆に「cis-体で二重鎖形成、trans-体で解離」というスイッチングが可能な光応答性DNAの設計と実現に成功した。ヘアピンとバルジによる並行計算:萩谷は、Whiplash PCRの熱力学的な解析と、状態遷移の効率化(Displacement WPCR)を行った。レトロウィルスによる並行計算:陶山は、二つの正帰還と一つの負帰還反応から構成されたオシレータをRTRACの基本反応を用いて構築した。シミュレーションにより発振可能な条件が存在することを確かめた後、実装を進めた。翻訳系による並行計算:横山は、翻訳システムを利用した「オートマトン」を動物細胞(培養細胞)内でも構築することを目標に、非天然型アミノ酸が細胞に与えられた場合にのみ活性化され、サプレッサーtRNAにアミノ酸を結合するような酵素(アミノアシルtRNA合成酵素)を用いることにより、サプレションを制御する機構を構築した。DNA Walker:萩谷は、DNA Walkerの構築に向けて、温度、pH、光の三種類の入力によって駆動する分子マシンに関する予備実験を行った。特に、これらの三種類の入力の独立性について調べた。マイクロチップのための微量液体制御機構の開発:藤井は、液滴操作に必要な周辺技術等の整備を進め、オンデマンド式で液滴の生成・合一の操作が可能にした。また、本技術を用いてDNAとPNAのハイブリダイゼーション反応と電気泳動による反応産物の分離操作をデバイス上で実現した

  11. Development of Two-Dimensional Chemical Sensor as Electronic Sense Organ

    YOSHINOBU Tatsuo, IWASAKI Hiroshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    2004 - 2005

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    As a platform for chemical sensors that can simultaneously detect many chemical species, a measurement system based on the light-addressable potentiometric sensor (LAPS) was developed. 1.Development of thin-film a-Si LAPS The spatial resolution of the LAPS depends on the beam size of the laser beam as a light source, the thickness of the semiconductor layer and the diffusion length of minority carriers. Compared with the LAPS with a bulk Si substrate, the thin-film a-Si LAPS is advantageous for high spatial resolution, realization of large-area sensor and combination with optical sensing methods due to its translucency. It was demonstrated that the fabricated a-Si LAPS worked as a chemical sensor with a sensitivity comparable to that of the conventional LAPS. The spatial resolution of this sensor was higher than 1μm. 2.Micropatterning of biomolecules For the application of LAPS to biosensors and biochips, the micropatterning technology was developed for immobilization of biomolecules on the semiconductor surface. The probe of an atomic force microscope (AFM) was used for local anodic oxidation of the semiconductor surface, and the oxide pattern was employed as a template for immobilization of biomolecules. With this technology, it was possible to fabricate structures such as a line pattern of protein molecules with a thickness narrower than 100nm and a DNA wire structure. 3.Fabrication of sensors with microchannels For highly efficient measurement of analyte with a small valume, a sensor chip with a microchannel was fabricated. The SU-8 walls were fabricated with photolithography, and a glass plate with a conductive film was used as the ceiling of the microchannel. By using a conductive ceiling, the current image of the microchannel became uniform.

  12. 革新的表面ナノバイオトロニクスに関する調査研究-次世代ポストゲノム医理工連携研究の促進を目指して-

    庭野 道夫, 宇理須 恒雄, 岩澤 康裕, 岩崎 裕, 吉信 達夫, 荻野 俊郎

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2004 - 2004

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    DNAの塩基配列の解読により、生命現象を解析するプロテオミクスや、SNP(単一塩基多型)解析に基づいたオーダーメイド医療の実現など、21世紀のバイオテクノロジーを牽引する研究が活発になりつつある。これらの研究を進展させるためには、生体関連物質の高感度分析・解析技術の開発が必要不可欠であり、その技術開発には,20世紀に成熟した半導体エレクトロニクス技術、特に表面ナノスケール制御・解析技術と,バイオテクノロジーとのインテリジェントな融合が有効である.この融合をわれわれは「表面ナノバイオトロニクス」と名づける。この「表面ナノバイオトロニクス」の目標は,表面という2次元空間を作業空間として、生体情報を物理信号(エレクトロン(電子)やフォトン(光子)など)に高効率に変換し,また,その逆に物理信号を生体系にフィードバックするような、高度なバイオ・インタフェイスシステムを構築することである。国内外を見るに、現在,この種の研究は緒についたばかりである。そこで本研究は、半導体工学や表面科学の研究者と、生命科学、バイオテクノロジー分野の研究者が、有機的な医理工連携を図ることにより、「表面ナノバイオトロニクス」技術の戦略目標を討論することを目的とした。 平成16年(2004年)には、応用物理学会秋季大会シンポジウム「ナノバイオテクノロジーにおける表面・界面の課題」を開催し、本研究のメンバーを中心に講演・討論を行った。さらに、平成16年10月に内外の著名な研究者を招待して国際研究集会「International Workshop on Surface-Biotronics」(東京)を開催し、表面バイオトロニクスに関する研究調査を行い、関連情報の収集に努めた。 以上の調査研究に基づいて、平成17年度発足の特定領域研究「生体階層構造に適合した表面バイオトロニクスの創成」(代表:岩崎裕)を申請した。

  13. Development of the multi-ion-imaging sensor and its application to biological specimens

    YOSHINOBU Tatsuo, IWASAKI Hiroshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Osaka University

    2002 - 2003

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    1. Development of multi-ion-imaging technology The conditions for the fabrication of ion-sensitive membranes with ionophores were optimized to implement various ion sensitivities on the sensing surface of the light-addressable potentiometric sensor (LAPS). A photo-patterning process was developed for the integration of ion-sensitive photocurable membranes on a single sensor chip. The distribution of the ion concentration was visualized with a sensor with integrated K^+-and Ca^<2+>-sensitive membranes. 2. Development of Enzyme LAPS For the application of the LAPS and the chemical imaging sensor to biological specimens, enzyme LAPS was developed with urease and butyrylcholinesterase. Various methods for the immobilization of enzyme molecules on the sensor surface were compared in terms of sensitivity and stability. 3. Development of a pen-shaped portable LAPS device To allow more flexible use of LAPS; a pen-shaped portable LAPS device was developed. The control and measurement circuits are built in the device, which can be directly dipped into the solution to be measured. The sensor chip has 4 or 16 measurement points on the surface, each of which can be independently assigned for measurement of different ion species. 4. Application to the microfluidic devices For the application to the detection and measurement of chemical species in the microfluidic devices such as μTAS and Lab-on-a-Chip, a LAPS-based system was combined with a microfluidic channels fabricated with the SU-8/PDMS technology. This system allows label-free measurement of ion concentration at an arbitrary point in the microchannel. The distribution of the ion concentration in the microchannel was visualized.

  14. 実時間化学イメージングシステムの開発

    吉信 達夫, 岩崎 裕

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 大阪大学

    1997 - 1999

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    本グループでは、電解質溶液またはゲル状試料中におけるpH等の化学的情報の2次元的な空間分布を画像化することができる、化学イメージングセンサの開発を行ってきた。この方法では、センサ表面の電荷によって半導体層中に空乏層幅の分布が生じることを利用して、その静電容量を場所ごとに読み出していくことになる。具体的にはセンサ裏面から変調レーザビームを照射し、静電容量に応じて外部回路に流れる交流光電流を計測する。現在までに、空間分解能10ミクロン、pH分解能0.01、測定速度毎秒100ピクセルを達成している。このうち、空間分解能およびpH分解能については多くのアプリケーションにおいて十分な値であるが、測定速度については1画面の測定に分オーダーの時間を要することから、変化の速い現象の測定に用いることは困難であった。 そこで本研究では化学イメージングセンサの実時間化に向けて装置および測定方式の改良を行った。昨年度は各ピクセルごとの測定に単発の光パルスを用いることで10倍以上の高速化を達成し、また低周波ノイズの影響が低減できることを明らかにした。本年度は化学イメージングセンサを用いて、ゲル中におけるイオンの拡散を可視化し、拡散係数の計測に応用できることを明らかにした。平行平板電極を有する電気化学システムにおいて、電気分解によって生じる電極間のpH分布が時間とともに変化する様子を観測し、pH分布の時間変化から拡散係数を計測した。また、分子量の異なるイオンについて各々の拡散係数を求め、分子量との関係を調べた。

  15. Development of Amperometric Biochemical Imaging Sensors Using Photoconductive Materials

    IWASAKI Hiroshi, KITAGAWA Masatosi, YOSHINOBU Tatsuo, SAKATA Yoshiteru

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Osaka University

    1997 - 1999

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    In this study, the chemical imaging sensor system was further developed to achieve higher performance and multifunctions that will meet the requirements of future applications. As an example, a dynamically changing electrochemical system was visualized and quantitatively analyzed. Visualization of chemical quantities other than pH was realized. A high-speed measurement system was proposed. Firstly, the diffusion process of ions was observed by measuring the distribution of ion concentrations in the proximity of the electrode after electrolysis. The Gaussian distribution of the ion concentration was observed as derived from the Fick's law. The ionic diffusion constants were experimentally determined for various ions. Secoedly, a sensor with a Au dot array pattern was developed for visualization of the redox potential distribution. As an application, the photo response of the porphirin was measured. Finally, a high-speed measurement system was proposed for the chemical imaging sensor. The technologies developed in this study can be combined and applied to chemical imaging of various specimens.

  16. ナノ構造界面・断面構造の評価と制御に関する研究

    吉信 達夫, 岩崎 裕

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 重点領域研究

    Institution: 大阪大学

    1997 - 1997

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    本年度はナノ構造形成への応用が考えられるステップのバンチングとファセッティングについて調べた。これらの方法により、原子レベルで平坦なステップフリーの広いテラスが得られ、ナノ構造の形成や量子機能の発現に有利であるほか、高さや密度を制御した多段ステップを量子細線の作製に利用したり、核生成サイトとしての応用が考えられる。 Si(111)微斜面における直流電流の通電によるステップのバンチングおよびデバンチングの過程をin situで観察することができる光散乱測定装置を試作した。超高真空中チャンバ内に置いた試料に対して約1240℃でステップダウン方向に通電加熱を行ない回折光を測定した。その結果、平均テラス幅は3〜14ミクロンの広い範囲にわたって時間の1/2乗に比例して増加することがわかった。またテラス幅分布の標準偏差は平均テラス幅の0.24倍であった。次にステップアップ方向に通電を行なったところ回折ピークの位置は変化せず次第にピークが消滅する様子が観察された。デバンチングにおいてはバンチの間隔は変化せずに各バンチが崩壊していることを示している。 また、Si(113)微斜面においてアニールによるファセッティングの様子を超高真空STMで調べた。高温側ではsingle step相となるのに対して、700℃以下ではファセッティングが進行し、テラス幅が時間の1/6乗で増加することを確認した。また、近距離でのステップ間相互作用を考慮したモンテカルロシミュレーションによってこれを再現した。

  17. DNA鎖を用いた分子コンピューティングの実現手法に関する研究

    岩崎 裕, 吉信 達夫, 谷澤 克行, 樹下 行三

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 萌芽的研究

    Institution: 大阪大学

    1996 - 1997

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    DNAコンピューティングは、DNAの分子認識機能を利用することによって、モル当たりアボガドロ数オーダーの超並列演算を可能にする方法として期待されており、特に、NP完全問題のように問題の規模に対して計算量が著しく増大する場合において、従来の計算機に比べて取り扱える問題の規模が大きくなることが期待されている。DNAコンピューティングについては、これまでにいくつかのインプリメンテーションが提案されており、小規模な問題については実際に演算も行なわれているが、必ずしもそのまま大規模な問題に対してスケーラブルではない。 本研究では、まず、組み合わせ問題のブール代数化と、DNA鎖長へのコーディングを用いてナップサック問題を解くアルゴリズムを提案し、実際に小規模な問題について演算を行ない、解の有無を判定することができた。この方法では、まず、DNA断片の全ての組み合わせからなるDNAをLigation反応によって生成した後、PCR反応によって条件を満たす組み合わせのみを増幅し、電気泳動によって解の有無を判定する。また、解となる組み合わせを具体的に知る方法として、大腸菌プラスミドを用いたクローニングを行ない、DNA配列を読み取った。この方法では、複数の解が存在する場合にも各々分離して解が得られるという利点がある。 さらに、DNAコンピューティングにおいて問題の規模を大きくする際に現実的な問題として現われるてくるであろう、分子生物学的プロセスの信頼性の問題に注目し、間違った組み合わせに対してLigation反応が起こる割合を塩基対ごとに調べ、エラー率の評価を行なった。

  18. ナノ構造界面・断面構造の評価と制御に関する研究

    吉信 達夫, 岩崎 裕

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 重点領域研究

    Institution: 大阪大学

    1996 - 1996

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    本研究では、単電子デバイス構造製作時の結晶成長や加工において問題となるラフニングや、デバイスの長時間安定性にとって問題となるナノ構造やステップ構造の熱的揺らぎについての知見を得ることを目的とし、統計力学に基づいた解析、及びSi表面のSTM観察を行なった。 まず、熱平衡状態における微斜面上の原子ステップの揺らぎの性質をSolid-On-Solid(SOS)モデルに基づいたモンテカルロシミュレーションで調べた。SAステップ及びSBステップの2種類のステップが交互に存在するSi(001)表面に対して、熱平衡状態のシミュレーション像と実際の表面のSTM像におけるステップのゆらぎを比較することにより、結合エネルギーをおよそε(SA)=0.15eV、ε(SB)=0.046eVと見積もった。 熱平衡状態以外では、MBE成長時における表面のカイネティックラフニングと成長条件の関係や、Si(113)表面におけるステップバンチングの時間依存性について調べた。MBE成長のモンテカルロシミュレーションでは表面マイグレーション距離に応じてバリスティックデポジション→3次元成長→レイヤーバイレイヤーモード→ステップフローモードと変化する様子を観察した。 また、実際にナノ構造の揺らぎが電気的特性に与える影響を調べるための準備として、AFM探針を用いたSi表面やAl細線の酸化加工を行ない、幅20nm長さ1μmの細線を作製した。

  19. 表面電位顕微法による神経回路網成長発達の研究

    岩崎 裕, 杉原 宏和, 吉信 達夫

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 重点領域研究

    Institution: 大阪大学

    1995 - 1995

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    本研究では、シリコン窒化膜で覆われたシリコン基板をセンサ面とし、同センサ面上の2次元電位の変化とその分布を顕微的に高速にイメージングする事が可能な装置を新たに開発し、その動作を確認した。さらにこのセンサ面上に人工的に培養した動物の神経細胞を伝達する活動電位を測定することを試み、予備的な結果を得た。 センサ面上で神経細胞を培養し、センサ面上に張り付いた神経細胞の活動電位を測定する場合には、(1)神経培養液の電位と半導体基板電位との差により直流バイアス電位差がセンサ面上に均一に印加されている。(2)神経に活動電位が生じた場合には、神経細胞の内部の電位が外部の電位=培養液の電位に対しパルス的に正に振れ、細胞膜と絶縁膜を介して容量結合により半導体基板のバンドの曲がり方が変化し、交流光電流の振幅が変調されることになる。 本装置の動作を確認するため、センサ面上に金属電極ドットを設け、半導体基板との間に適当な直流バイアスを印加し、パルス電位を重畳し変調光を照射した時の交流光電流の振幅を測定し、交流光電流の振幅がパルス電位により変調されていることを確認した。実際の神経細胞において活動電位の変化を位置敏感に測定できるこを確認するためには、比較的大きな単一又は少数の神経細胞を培養し、その活動電位をガラス電極と本センサで同時に測定し、それらの結果を比較する必要がある。 この目的のために、電極マニピュレータをシステムに組み込んだほか、アンプや培養装置など神経細胞を用いた実験を行なう環境を整備した。また、東海大学の榊原教授に御指導いただき、ウミウシの神経細胞をセンサ基板上に張り付くように培養できる条件を確立し、今後はこの細胞を用いた活動電位測定の実験を行なう予定である。

  20. Developement of a novel laser-beam-scanning bio-chemical sensing microscope

    IWASAKI Hiroshi, MITSUMATA Tadayasu, YOSHINOBU Tatsuo

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Developmental Scientific Research (B)

    Institution: Osaka University

    1993 - 1995

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    A novel chemical imaging microscope has been developed with the aid of the present grant. The chemical imaging microscope is based on the principle of the light-addressable potentiometric sensor (LAPS). The sensing surface of a LAPS device in contact with the electrolyte is made of insulating Si _3N_4 film deposited on semiconducting Si substrate. The two-dimensional chemical information in the electrolyte is mapped into the variation of the width of depletion layr in Si substrate. The electrical impedance of the depletion layr is measured as a function of position, in the form of photocurrent induced by scanning-laser-beam that illuminates the rear surface of the Si substrate. The spatial resolution, sensitivity and measurement speed have been investigated and improved to be 10 micron meter, 0.01pH and 100 pixels/sec, respectively. The microscope has been verified to have capability of visualization of two-dimensional bio/chemical information in electrolytic specimens ; distribution of pH of microorganism colonies, specific molecules and redox potential.It could be also used for imaging rapidly changing electrical-potential such as active neuron potential. To demonstrate its applicability to faster processes, we measured the chemical waves in Belousov-Zhabotinsky reaction. Propagation of chemical waves was observed as variation of redox potential either at a fixed point or on a line along the propagating direction. Such measurement would be useful for microscopic analysis of reaction-diffusion and pattern-formation phenomena in redox reaction systems.

  21. Development of an Ultra-Clean Closed- Multi-Wet Processing-System and Study of Si/Liquid lnterfaces

    IWASAKI Hiroshi, WHOANBEAG Young, YOSHINBU Tatsuo

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for General Scientific Research (B)

    Institution: Osaka University

    1992 - 1994

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    Ultra clean and precisely controlled wet processes such as ultra pure water cleaning and wet chemical etching processes of ULSI are required for further progresses of semiconductor technology. In this study, as the first step to study new wet treating procedures and apparatus which satisfy such high quality demands, we have newly developed an ultra-clean closed multi-wet process system and confirmed the improved multi-wet treatment. Main results are described as follows. A flow system which is capable of RCA cleaning has been developed. Better solution replacement characteristic than conventional over-flow system and superior wet treatment characteristics have been achieved. For example, in etching uniformity of oxide layr on 4 inch wafer, average etching rate was 50.5 A/min.for 10 minute etching by HF at 17ﾟC and uniformity of etching rate in the surface was 1.15 A/min.by rms, less than ? B12.3%. Electrochemical STM study was performed for observation of interface between Si and solution in wet processes. At first, step structures were observed on HF treated Si (111) surfaces and the rms roughness of the surface in 50x50 nm^2 area was 0.60 A.Secondly, the double layr steps of a height of 3.2 A were observed on NH_4F treated Si (111) surface and the rms value of the surface was 0.38 A,which is flatter than the HF treated surface in agreement with previous reports. Surface roughening in mesoscopic scale by surface processes such as chemical etching of Si was studied with STM and AFM experimentally and scaling characteristics of surface roughness, especially self-affine roughness index and characteristic correlation length were measured. Further study to make clear the superiority of newly developed wet processes is in progress.

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