Details of the Researcher

PHOTO

Fumihiko Nitta
Section
Tohoku University Hospital
Job title
Senior Assistant Professor
Degree

  • Doctor of Philosophy (Tohoku University)

Professional Memberships 1

  • 日本網膜硝子体学会

Papers 24

  1. Impact of Intravitreal Ranibizumab on Retinopathy of Prematurity: A Retrospective Analysis. International-journal

    Fumihiko Nitta, Hiroshi Kunikata, Shimpei Watanabe, Toru Nakazawa

    Cureus　18　(3)　e105794　2026/03

    DOI： 10.7759/cureus.105794 　

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    Purpose The purpose of this study was to evaluate the impact of intravitreal ranibizumab (IVR) introduction on treatment patterns for retinopathy of prematurity (ROP) and the incidence of severe complications, including retinal detachment (RD), in a real-world setting. Methods We retrospectively analyzed 785 infants born at ≤1800 g or ≤34 weeks of gestation between January 2016 and December 2022 at two tertiary hospitals in Japan. IVR (0.2 mg/0.02 mL) was introduced in August 2020 at Tohoku University Hospital and in December 2019 at Miyagi Children's Hospital. Infants meeting Early Treatment for Retinopathy of Prematurity (ETROP) criteria received either retinal photocoagulation (RPC), IVR, or both, depending on the treatment era. Severe cases with RD (stage 4A or higher) were managed with scleral buckling or vitreous surgery as needed. Results Of the 472 infants treated prior to IVR introduction, 41.3% were extremely low birth weight (ELBW), comparable to 41.5% among the 291 infants treated after IVR introduction. The proportion undergoing RPC significantly decreased from 9.7% to 5.4% following IVR availability (p=0.03). Notably, the incidence of RD dropped from 2.1% to 0% after IVR introduction (p=0.01), despite no significant change in ELBW distribution. Conclusion The introduction of IVR has markedly shifted ROP treatment paradigms, reducing reliance on RPC and completely eliminating RD in our cohort. IVR offers a targeted, less destructive therapeutic alternative, potentially preserving retinal architecture and improving long-term visual outcomes. While these findings are encouraging, prospective studies are needed to further assess the safety and efficacy of IVR in this vulnerable population.

  2. Safety and Efficacy of Orally Administered SJP-0008 in Central Retinal Artery Occlusion: A Phase IIa Randomized Clinical Trial

    Satoru Tsuda, Hiroshi Kunikata, Kazuki Hashimoto, Toshifumi Asano, Azusa Ito, Mitsuhide Yoshida, Masayuki Yasuda, Fumihiko Nitta, Toru Nakazawa

    OPHTHALMOLOGY SCIENCE　6　(1)　2026/01

    DOI： 10.1016/j.xops.2025.100965 　

    ISSN： 2666-9145

  3. Safety and Efficacy of Orally Administered SJP-0008 in Central Retinal Artery Occlusion: A Phase IIa Randomized Clinical Trial. International-journal

    Satoru Tsuda, Hiroshi Kunikata, Kazuki Hashimoto, Toshifumi Asano, Azusa Ito, Mitsuhide Yoshida, Masayuki Yasuda, Fumihiko Nitta, Toru Nakazawa

    Ophthalmology science　6　(1)　100965-100965　2026/01

    DOI： 10.1016/j.xops.2025.100965 　

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    PURPOSE: To assess the efficacy and safety of orally administered calpain inhibitor SJP-0008 in Japanese patients with central retinal artery occlusion (CRAO), to establish a disease registry for the prospective tracking of observational data from patients with CRAO, intended for regulatory use, and to support the development of new therapeutic agents for CRAO. DESIGN: This was a 2-part study. Part 1 was a physician-/investigator-initiated, phase IIa, single-center, randomized, double-blinded, parallel-group study. Part 2 was a prospective cohort study, during which the CRAO registry was established, and included patients diagnosed with CRAO (including a nonrandomized registry cohort, the non-SJP group, which did not receive SJP-0008). Additionally, in part 2, a combined analysis was performed using data from part 1 patients. PARTICIPANTS: The study participants were patients recruited within 48 hours of developing CRAO. METHODS: SJP-0008 administration was initiated at least 3 hours but no more than 48 hours after the onset of CRAO. Patients were randomized in a 1:1 ratio using masked randomization to receive either 100-mg or 200-mg doses of SJP-0008. The dosing period was defined as the 4-week postinitiation period (up to 29 days), followed by an 8-week postobservation phase. MAIN OUTCOME MEASURES: The main outcome measure was to determine the efficacy of SJP-0008 treatment; the primary endpoint was the change in ETDRS visual acuity at 12 weeks in the target eye of patients with CRAO. RESULTS: The study included 28 patients (mean age: 68.8 ± 14.9 years; 78.6% male). ETDRS scores (mean [95% confidence interval]) were higher at week 12 than at baseline in both the 100-mg (27.9 letters [10.14, 45.61]) and 200-mg (25.7 letters [12.02, 39.40]) SJP-0008 groups, in contrast to the non-SJP group (10.2 letters [4.58, 15.76]). The improvement in the 200-mg SJP-0008 group was greater than in the nonrandomized non-SJP group (P = 0.040). No safety concerns were identified. CONCLUSIONS: The preliminary study supports the safety and efficacy of oral administration of SJP-0008 for treating CRAO, with greater improvement compared with the nonrandomized registry cohort. However, large-scale, multicenter randomized controlled trials are warranted to validate the findings of this study. FINANCIAL DISCLOSURES: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

  4. Systemic oxidative stress levels and their associations with the risk of neovascular age-related macular degeneration and treatment response. International-journal

    Maiko Abe, Hiroshi Kunikata, Naoko Aizawa, Masayuki Yasuda, Fumihiko Nitta, Toshiaki Abe, Toru Nakazawa

    International journal of retina and vitreous　11　(1)　16-16　2025/02/10

    DOI： 10.1186/s40942-025-00632-1 　

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    PURPOSE: To investigate the association between oxidative stress (OS) and both the risk of neovascular age-related macular degeneration (nAMD) and the treatment response to intravitreal anti-vascular endothelial growth factor injections (anti-VEGF IVIs). METHODS: This retrospective study included 46 treatment-naïve nAMD eyes of 46 patients (26 male and 20 female) who received anti-VEGF IVIs with a "treat-and-extend" regimen following an initial loading phase for one year. The patients were divided into two groups according to the total number of anti-VEGF IVIs administered during the year: the "effective" group and the "resistant" group. OS was evaluated by diacron reactive oxygen metabolites (d-ROMs), biological antioxidant potential (BAP), and skin autofluorescence (SAF) at baseline. For comparison, 54 control subjects were recruited. RESULTS: There were no significant differences in d-ROM or BAP levels between control subjects and nAMD patients, regardless of sex, whereas SAF levels were higher in nAMD patients overall and in male nAMD patients than in controls (P < 0.001 for both). The effective and resistant groups included 30 and 16 eyes, respectively. Among the male nAMD patients, the effective and resistant groups had similar baseline characteristics, including age, smoking history, visual acuity, and central macular thickness; however, the resistant group had higher SAF levels (effective vs. resistant: 2.3 vs. 2.6 arbitrary units [AU]; P = 0.02). This finding was further supported by a multiple logistic regression analysis, which showed that the odds ratio for SAF was 1.57 per 0.1 AU increase (P = 0.01). CONCLUSION: SAF levels were significantly higher in nAMD patients than in controls. The total number of anti-VEGF IVIs required over one year in male nAMD patients depended on SAF levels, suggesting that the SAF levels may serve as a potential biomarker for the response to anti-VEGF IVIs in nAMD.

  5. Systemic Oxidative Stress Level as a Pathological and Prognostic Factor in Myopic Choroidal Neovascularization

    Jiying Wang, Hiroshi Kunikata, Masayuki Yasuda, Noriko Himori, Fumihiko Nitta, Toru Nakazawa

    Ophthalmology Science　4　(6)　2024/11/01

    DOI： 10.1016/j.xops.2024.100550 　

    eISSN： 2666-9145

  6. 裂孔原性網膜剥離における術後高眼圧の術式別検討

    新田 文彦, 國方 彦志, 阿部 俊明, 中澤 徹

    臨床眼科　77　(10)　1269-1274　2023/10

    Publisher: (株)医学書院

    ISSN： 0370-5579

    eISSN： 1882-1308

  7. 裂孔原性網膜剥離における術後高眼圧の術式別検討

    新田 文彦, 國方 彦志, 阿部 俊明, 中澤 徹

    臨床眼科　77　(10)　1269-1274　2023/10

    Publisher: (株)医学書院

    ISSN： 0370-5579

    eISSN： 1882-1308

  8. 硝子体手術により腫瘍摘出を行った網膜血管増殖性腫瘍の1例

    新田 文彦, 國方 彦志, 古田 実, 阿部 俊明, 中澤 徹

    臨床眼科　76　(5)　677-683　2022/05

    Publisher: (株)医学書院

    ISSN： 0370-5579

    eISSN： 1882-1308

  9. 硝子体手術により腫瘍摘出を行った網膜血管増殖性腫瘍の1例

    新田 文彦, 國方 彦志, 古田 実, 阿部 俊明, 中澤 徹

    臨床眼科　76　(5)　677-683　2022/05

    Publisher: (株)医学書院

    ISSN： 0370-5579

    eISSN： 1882-1308

  10. 滲出型加齢黄斑変性に対するブロルシズマブ投与前後の眼血流評価

    瀧澤 廣輝, 安田 正幸, 國方 彦志, 王 英紀, 星 佳佑, 岡部 達, 新田 文彦, 阿部 俊明, 中澤 徹

    日本眼科学会雑誌　126　(臨増)　187-187　2022/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  11. 外傷性黄斑円孔に対する硝子体手術成績

    長田 麗, 國方 彦志, 新田 文彦, 阿部 俊明, 中澤 徹

    眼科臨床紀要　14　(11)　754-754　2021/11

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  12. Bilateral diffuse uveal melanocytic proliferationの1例

    新田 文彦, 西口 康二, 國方 彦志, 中澤 徹

    眼科臨床紀要　14　(11)　771-772　2021/11

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  13. MRIにて発見された鉄片異物による遅発性眼内炎の1例

    新田 文彦, 國方 彦志, 西口 康二, 阿部 俊明, 中澤 徹

    臨床眼科　75　(7)　947-952　2021/07

    Publisher: (株)医学書院

    ISSN： 0370-5579

    eISSN： 1882-1308

  14. Concurrent analogous organ damage in the brain, eyes, and kidneys in malignant hypertension: reversible encephalopathy, serous retinal detachment, and proteinuria. International-journal

    Eikan Mishima, Yukino Funayama, Takehiro Suzuki, Fumiko Mishima, Fumihiko Nitta, Takafumi Toyohara, Koichi Kikuchi, Hiroshi Kunikata, Junichiro Hashimoto, Mariko Miyazaki, Hideo Harigae, Toru Nakazawa, Sadayoshi Ito, Takaaki Abe

    Hypertension research : official journal of the Japanese Society of Hypertension　44　(1)　88-97　2020/07/27

    DOI： 10.1038/s41440-020-0521-2 　

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    Malignant hypertension, a form of hypertensive emergency, causes acute damage in vital organs such as the brain, eyes, and kidneys. We aimed to examine the concurrency of acute hypertensive damage across the target organs to elucidate the underlying analogous pathophysiology. This single-center retrospective study evaluated the characteristics of organ damage, short-term clinical course, and interorgan relationships in patients with malignant hypertension treated between 2008 and 2019. Baseline characteristics of 20 patients who met our inclusion criteria were mean age 48 ± 13 years and blood pressure 222 ± 18/142 ± 16 mmHg; the median estimated glomerular filtration rate and urinary protein level were 49 mL/min/1.73 m2 (interquartile range [IQR] 27-79) and 1.9 g/g creatinine (IQR 0.2-4.0), respectively. Posterior reversible encephalopathy syndrome (PRES) was found in 60% of patients with major involvement and a wide variety of distribution patterns in the brainstem. In the fundus, serous retinal detachment was found in 60% of patients. Patients with PRES and serous retinal detachment showed higher levels of urinary protein than those without symptoms (P = 0.007 and 0.02, respectively), and proteinuria >1 g/g creatinine highly complicated both PRES and serous retinal detachment (91%). Matrix analysis also showed that the three symptoms were highly associated with each other. These results demonstrate the close relationship and concurrency of hypertensive acute organ damage in the brain, eyes, and kidneys. A common analogous mechanism, such as hyperperfusion-induced capillary leakage in each organ, implies an underlying pathophysiology of PRES, serous retinal detachment, and proteinuria.

  15. 経角膜硝子体切除を併用した眼内レンズ強膜内固定術3症例の検討 Peer-reviewed

    新田 文彦, 國方 彦志, 大友 孝昭, 西口 康二, 阿部 俊明, 中澤 徹

    臨床眼科　74　(5)　582-588　2020/05

    Publisher: (株)医学書院

    ISSN： 0370-5579

    eISSN： 1882-1308

  16. Pars plana vitrectomy with endolaser cyclophotocoagulation for refractory glaucoma in eleven eyes

    Nana Takahashi, Yu Yokoyama, Hiroshi Kunikata, Koji Nishiguchi, Fumihiko Nitta, Takayuki Takeshita, Toru Nakazawa

    Japanese Journal of Clinical Ophthalmology　72　(10)　1451-1458　2018/10

    ISSN： 0370-5579

  17. Age- and Sex-Dependency of Laser Speckle Flowgraphy Measurements of Optic Nerve Vessel Microcirculation. International-journal

    Naoko Aizawa, Hiroshi Kunikata, Fumihiko Nitta, Yukihiro Shiga, Kazuko Omodaka, Satoru Tsuda, Toru Nakazawa

    PloS one　11　(2)　e0148812　2016

    DOI： 10.1371/journal.pone.0148812 　

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    PURPOSE: To investigate the relationship between various characteristics of a normal population and laser speckle flowgraphy (LSFG) measurements of mean blur rate (MBR) in the optic nerve head (ONH). METHODS: A total of 189 eyes of 189 normal subjects (93 male, 96 female, mean age 45 ± 14 years old, age range: 20-72) without any history of hypertension, hyperlipidemia or diabetes were enrolled. ONH microcirculation was measured with LSFG and overall MBR (MA), vessel-area MBR (MV), and tissue-area MBR (MT) were derived from these measurements. The statistical association of these measurements with characteristics such as sex, age, intraocular pressure (IOP) and systolic blood pressure (SBP) was then determined. RESULTS: There was a trend towards decreased IOP and MV and increased SBP with age (P = 0.002, P = 0.035, and P = 0.006, respectively). Furthermore, IOP, MV and SBP were correlated with age (r = -0.23, P = 0.011; r = -0.24, P < 0.001; and r = 0.30, P < 0.001, respectively). Separate multiple regression analyses of independent contributing factors revealed that sex and IOP contributed to MA (P < 0.001 and P = 0.002, respectively), sex, IOP, and age contributed to MV (P < 0.001, P = 0.003, and P = 0.024, respectively), while only IOP contributed to MT (P = 0.003). CONCLUSION: In a normal population, MBR was affected by IOP in both the large vessel and capillary areas of the ONH, but not by SBP. MV was also affected by age and sex, while MT was stable independent of age or sex.

  18. The relationship between laser speckle flowgraphy-measured optic disc microcirculation and postoperative visual recovery in rhegmatogenous retinal detachment. International-journal

    Naoko Aizawa, Hiroshi Kunikata, Fumihiko Nitta, Toru Nakazawa

    Acta ophthalmologica　93　(5)　e397-9　2015/08

    DOI： 10.1111/aos.12586 　

  19. Relationship of ocular microcirculation, measured by laser speckle flowgraphy, and silent brain infarction in primary aldosteronism. International-journal

    Hiroshi Kunikata, Naoko Aizawa, Masataka Kudo, Shunji Mugikura, Fumihiko Nitta, Ryo Morimoto, Yoshitsugu Iwakura, Yoshikiyo Ono, Fumitoshi Satoh, Hidetoshi Takahashi, Sadayoshi Ito, Shoki Takahashi, Toru Nakazawa

    PloS one　10　(2)　e0117452　2015

    DOI： 10.1371/journal.pone.0117452 　

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    PURPOSE: Recent studies have shown that the risk of cerebro- and cardiovascular events (CVEs) is higher in patients with primary aldosteronism (PA) than in those with essential hypertension (EH), and that silent brain infarction (SBI) is a risk factor and predictor of CVEs. Here, we evaluated the relationship between findings from laser speckle flowgraphy (LSFG), a recently introduced non-invasive means of measuring mean blur rate (MBR), an important biomarker of ocular blood flow, and the occurrence of SBI in patients with PA. METHODS: 87 PA patients without symptomatic cerebral events (mean 55.1 ± 11.2 years old, 48 male and 39 female) were enrolled in this study. We measured MBR in the optic nerve head (ONH) with LSFG and checked the occurrence of SBI with magnetic resonance imaging. We examined three MBR waveform variables: skew, blowout score (BOS) and blowout time (BOT). We also recorded clinical findings, including age, blood pressure, and plasma aldosterone concentration. RESULTS: PA patients with SBI (15 of 87 patients; 17%) were significantly older and had significantly lower BOT in the capillary area of the ONH than the patients without SBI (P = 0.02 and P = 0.03, respectively). Multiple logistic regression analysis revealed that age and BOT were independent factors for the presence of SBI in PA patients (OR, 1.15, 95% CI 1.01-1.38; P = .03 and OR, 0.73, 95% CI 0.45-0.99; P = .04, respectively). CONCLUSION: PA patients with SBI were older and had lower MBR BOT than those without SBI. Our analysis showed that age was a risk factor for SBI, and that BOT was a protective factor, in patients with PA. This suggests that BOT, a non-invasive and objective biomarker, may be a useful predictor of SBI and form part of future PA evaluations and clinical decision-making.

  20. Laser speckle and hydrogen gas clearance measurements of optic nerve circulation in albino and pigmented rabbits with or without optic disc atrophy. International-journal

    Naoko Aizawa, Fumihiko Nitta, Hiroshi Kunikata, Tetsuya Sugiyama, Tsunehiko Ikeda, Makoto Araie, Toru Nakazawa

    Investigative ophthalmology & visual science　55　(12)　7991-6　2014/11/06

    DOI： 10.1167/iovs.14-15373 　

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    PURPOSE: The purpose of this study was to evaluate the correlation between laser speckle flowgraphy measurements of mean blur rate (MBR) and hydrogen gas clearance measurements of capillary blood flow (CBF) in the optic nerve head (ONH) of albino and pigmented rabbits, with or without chronic ischemia-induced ONH atrophy. METHODS: The ONH MBR and ONH CBF were measured at baseline, 30 and 60 minutes after the intravenous administration of endothelin-1 (ET-1) (10(-10) mol/kg) in six albino and six pigmented rabbit eyes. The ONH MBR and ONH CBF were also measured in nine pigmented rabbit eyes that underwent the intravitreal administration of ET-1 (20 pmol) twice per week for 4 weeks to provoke chronic ischemia-induced ONH atrophy. RESULTS: In the group that received intravenous ET-1, average measurements of ONH MBR and ONH CBF at all time points were correlated in both the albino (r = 0.88, P < 0.001, n = 18) and pigmented rabbits (r = 0.85, P < 0.001, n = 18), with no intrarabbit correlations (P = 0.524). The ONH MBR and ONH CBF were also correlated in the model of chronic ischemia-induced ONH atrophy (r = 0.78, P = 0.013, n = 9). Pooled ONH MBR and ONH CBF measurements in both the intravenous and intravitreal groups were also highly correlated (r = 0.87, P < 0.001, n = 45), with no significant intergroup differences in the relationship between ONH MBR and ONH CBF (P = 0.138). CONCLUSIONS: Regardless of the presence of fundus pigmentation or ONH atrophy, ONH MBR and ONH CBF were highly correlated, suggesting that MBR in the ONH tissue is usable for interindividual and intergroup comparisons.

  21. Relative flow volume, a novel blood flow index in the human retina derived from laser speckle flowgraphy. International-journal

    Yukihiro Shiga, Toshifumi Asano, Hiroshi Kunikata, Fumihiko Nitta, Hajime Sato, Toru Nakazawa, Masahiko Shimura

    Investigative ophthalmology & visual science　55　(6)　3899-904　2014/05/29

    DOI： 10.1167/iovs.14-14116 　

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    PURPOSE: We investigated the accuracy and reproducibility of relative flow volume (RFV), a novel index of blood flow in the human retina derived from laser speckle flowgraphy (LSFG). METHODS: Pre- and postbranch retinal RFV measurements were compared in 34 retinal venous bifurcations in 34 healthy volunteers (mean age, 49.0 ± 14.8 years) to determine the accuracy of RFV. Next, the coefficient of variation (COV) of RFV was determined for 30 temporal retinal arteries in a second group of 18 healthy volunteers (mean age, 30.3 ± 7.7 years). Finally, laser Doppler velocimetry (LDV) data were obtained from the same study population and compared to RFV data from the retinal vessels. RESULTS: A comparison of RFV measurements in a trunk vessel of the retina and the sum of its two daughter vessels revealed a strong correlation (r = 0.98, P < 0.001). Reproducibility analysis showed that the COV for RFV was 5.9% ± 3.6%. Linear regression analysis revealed that RFV was correlated significantly with LDV measurements of mean retinal blood velocity (vmean) and retinal blood flow (FLDV, vmean, r = 0.61, P < 0.001; FLDV, r = 0.51, P = 0.004, respectively), but not significantly correlated with ocular perfusion pressure (r = -0.04, P = 0.76). CONCLUSIONS: These results suggest that RFV values obtained with LSFG can be considered an accurate and reliable index of relative blood flow in the human retina. Thus, RFV, a novel LSFG-derived variable, has potential for assessing retinal blood flow alterations in ocular disease.

  22. The effect of intravitreal bevacizumab on ocular blood flow in diabetic retinopathy and branch retinal vein occlusion as measured by laser speckle flowgraphy. International-journal

    Fumihiko Nitta, Hiroshi Kunikata, Naoko Aizawa, Kazuko Omodaka, Yukihiro Shiga, Masayuki Yasuda, Toru Nakazawa

    Clinical ophthalmology (Auckland, N.Z.)　8　1119-27　2014

    DOI： 10.2147/OPTH.S62022 　

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    BACKGROUND: This study evaluated the effect of intravitreal injection of bevacizumab (IVB) on macular edema associated with diabetic retinopathy (DME) or branch retinal vein occlusion (BRVOME) using laser speckle flowgraphy. METHODS: A comparative interventional study of 25 eyes from 22 patients with macular edema (DME group: 12 eyes; BRVOME group: 13 eyes) who underwent IVB. Mean blur rate (MBR) was measured in the retinal artery, retinal vein, optic nerve head (ONH), and choroid before and after IVB. RESULTS: In the BRVOME group, there was no significant change in MBR in the retinal artery, retinal vein or ONH, but choroidal MBR decreased significantly (P=0.04). In the DME group, the MBR in the retinal artery, retinal vein, ONH, and choroid decreased significantly (P=0.02, P=0.04, P<0.001, and P=0.04, respectively). In the DME group, pre-IVB MBR in the ONH was significantly correlated with post-IVB foveal thickness (R= -0.71, P=0.002). There was no such correlation in the BRVOME group in the ONH. CONCLUSION: IVB had a suppressive effect on circulation in eyes with DME but not in those with BRVOME. This suggests that this noninvasive and objective biomarker may be a useful part of pre-IVB evaluations and decision-making in DME.

  23. Progression of visual field defects in eyes with different optic disc appearances in patients with normal tension glaucoma. International-journal

    Toru Nakazawa, Masahiko Shimura, Morin Ryu, Noriko Himori, Fumihiko Nitta, Kazuko Omodaka, Hiroshi Doi, Tomoki Yasui, Nobuo Fuse, Kohji Nishida

    Journal of glaucoma　21　(6)　426-30　2012/08

    DOI： 10.1097/IJG.0b013e3182182897 　

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    PURPOSE: To investigate the relationship between the optic disc appearance and the progression of visual field defects in eyes with normal tension glaucoma (NTG). METHODS: Two hundred nine patients with NTG, who were being treated with topical antiglaucoma drugs and had been followed for at least 3 years, were studied. The baseline optic disc appearance was classified into 4 types: focal ischemic (FI), myopic glaucomatous (MY), senile sclerotic (SS), and generalized cup enlargement (GE). The progression of the NTG was assessed by the slope of the mean deviations (MDs) obtained from the visual field results collected during the follow-up examinations. The baseline and mean intraocular pressures (IOPs) were also followed. RESULTS: Twenty-seven patients were placed in the FI group, 63 into the MY group, 24 into the SS group, and 43 into the GE group. Fifty-two patients (24.9%) could not be classified. There were no significant differences in the percentage reduction of the IOP among the 4 groups. The MD slope in the GE group (-0.51±0.74 dB/y) was significantly steeper than that in the other groups. Regression analyses showed that the factors most associated with the MD slope were the age in the FI (r, -0.495) and the GE (r=0.496) groups, and the relative reduction of the IOP (r=0.413) in the SS group. None of the factors in the MY group was significantly associated with the MD slope. CONCLUSIONS: The rate of progression of the field defects, the MD slope, in patients with NTG is possibly dependent on the baseline optic disc appearance. Thus, the optic disc appearance may be useful for the management of patients with NTG.

  24. Difficulty in inserting 25- and 23-gauge trocar cannula during vitrectomy. International-journal

    Hiroshi Kunikata, Fumihiko Nitta, Yasuhiko Meguro, Naoko Aizawa, Takehiro Hariya, Naoki Chiba, Toshiaki Abe, Kohji Nishida

    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde　226　(4)　198-204　2011

    DOI： 10.1159/000330745 　

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    PURPOSE: To determine the incidence of difficulty in inserting a 25- and 23-gauge trocar cannula (DITC) during 25- or 23-gauge micro-incision vitrectomy surgery (MIVS). METHODS: Retrospective, consecutive, interventional case series performed by a single surgeon at a single centre. We defined a DITC as the condition where at least 1 trocar cannula could not be inserted into the vitreous at the beginning of MIVS. The incidence of DITC was calculated from 1,525 eyes, and the pre-operative demographics of the DITC cases were compared to those of the non-DITC cases. RESULTS: The incidence of DITC for all cases was 0.6% (9 of 1,525 eyes). Overall, there were 242 eyes with a retinal detachment (RD), and 8 of the 9 eyes with DITC had an RD with an incidence of 3.3% (8 of 242 RD eyes). Seven of these 8 eyes had a total RD, 4 also had a choroidal detachment, 4 eyes were also myopic (>-8.0 dpt, high myopia), and 6 of the 8 eyes were hypotonic (<8 mm Hg). The DITC cases had larger RDs (p<0.0001), a higher incidence of choroidal detachment (p<0.0001), higher myopia (p=0.0204) and hypotony (p=0.0003) than the non-DITC eyes with an RD. CONCLUSIONS: A large RD, a choroidal detachment, high myopia and hypotony are significant risk factors for DITC. We recommend that MIVS should be performed cautiously for eyes with these risk factors.

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Misc. 42

  1. 滲出型加齢黄斑変性に対する抗VEGF療法後の薬剤別眼血流評価

    瀧澤廣輝, 安田正幸, 新田文彦, 國方彦志, 中澤徹

    日本眼循環学会講演抄録集　40th　2024

  2. A case of residual lens capsule transplantation and vitreous surgery for macular hole retinal detachment after secondary cataract treatment

    新田文彦, 國方彦志, 佐々木栞菜, 小山内亜紀, 中澤徹

    臨床眼科　78　(4)　2024

    ISSN： 0370-5579

  3. A study of lens tilt and decentration after intrascleral intraocular lens implantation

    佐々木栞菜, 新田文彦, 小山内亜紀, 國方彦志, 中澤徹

    臨床眼科　78　(4)　2024

    ISSN： 0370-5579

  4. 未熟児網膜症におけるラニビズマブ硝子体注射導入前後での臨床経過比較

    新田文彦, 新田文彦, 國方彦志, 太田裕也, 渡邊真平, 内田俊彦, 中澤徹

    日本網膜硝子体学会総会プログラム・講演抄録集　62nd　2023

  5. 滲出型加齢黄斑変性に対する抗VEGF薬投与前後の眼血流評価

    瀧澤廣輝, 安田正幸, 國方彦志, 星佳佑, 岡部達, 新田文彦, 中澤徹

    日本網膜硝子体学会総会プログラム・講演抄録集　62nd　2023

  6. 経角膜硝子体切除を併用した眼内レンズ強膜内固定術3症例の検討

    新田 文彦, 國方 彦志, 大友 孝昭, 西口 康二, 阿部 俊明, 中澤 徹

    臨床眼科　74　(5)　582-588　2020/05

    Publisher: (株)医学書院

    ISSN： 0370-5579

    eISSN： 1882-1308

  7. 治療抵抗性緑内障に対し硝子体手術併用眼内毛様体光凝固を施行した11例の検討

    高橋 成奈, 横山 悠, 國方 彦志, 西口 康二, 新田 文彦, 竹下 孝之, 中澤 徹

    臨床眼科　72　(10)　1451-1458　2018/10

    Publisher: (株)医学書院

    ISSN： 0370-5579

    eISSN： 1882-1308

  8. OCTアンジオグラフィによる黄斑剥離裂孔原性網膜剥離眼の検討

    油井奈保子, 國方彦志, 相澤奈帆子, 新田文彦, 大友孝昭, 西口康二, 阿部俊明, 中澤徹

    日本眼循環学会講演抄録集　35th　2018

  9. レーザースペックルによる網膜静脈分枝閉塞症でのラニビズマブ投与前後の眼血流変化

    新田 文彦, 國方 彦志, 相澤 奈帆子, 伊藤 梓, 阿部 俊明, 中澤 徹

    眼科臨床紀要　8　(11)　822-822　2015/11

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  10. 裂孔原性網膜剥離眼の視神経乳頭血流解析からみた視力予後因子

    相澤 奈帆子, 國方 彦志, 新田 文彦, 鈴木 哲章, 油井 理恵子, 中澤 徹

    眼科臨床紀要　8　(10)　764-764　2015/10

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  11. 眼疾患メカニズムの新しい理解 失明ゼロを目指して

    中澤 徹, 國方 彦志, 横倉 俊二, 丸山 和一, 西口 康二, 高橋 秀肇, 国松 志保, 劉 孟林, 檜森 紀子, 田中 佑治, 新田 文彦, 森藤 暁, 藤田 幸輔, 中村 織江, 面高 宗子, 安田 正幸, 横山 悠, 相澤 奈帆子, 山本 耕太郎, 雪田 昌克, 津田 聡, 志賀 由己浩, 前川 重人, 國分 太貴, 今野 瑛之, 高橋 麻衣, 萱場 寛子, 橋本 清香, 佐藤 茉莉華, 矢花 武史, 高田 菜生子, 高橋 世理, 鎌田 泰彰

    日本眼科学会雑誌　119　(3)　168-194　2015/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  12. 原発性アルドステロン症における眼底血流評価の臨床的意義について

    工藤 正孝, 國方 彦志, 相澤 奈帆子, 麦倉 俊司, 新田 文彦, 小野 美澄, 岩倉 芳倫, 尾股 慧, 森本 玲, 清治 和将, 高瀬 圭, 高橋 秀肇, 中澤 徹, 伊藤 貞嘉, 佐藤 文俊

    日本高血圧学会総会プログラム・抄録集　37回　368-368　2014/10

    Publisher: (NPO)日本高血圧学会

  13. 原発性アルドステロン症における非侵襲的眼血流測定法・レーザースペックルフローグラフィによる細動脈血管障害の評価

    工藤 正孝, 新田 文彦, 國方 彦志, 麦倉 俊司, 小野 美澄, 岩倉 芳倫, 松田 謙, 森本 玲, 相澤 奈帆子, 高橋 秀肇, 高橋 昭喜, 中澤 徹, 伊藤 貞嘉, 佐藤 文俊

    日本高血圧学会総会プログラム・抄録集　36回　286-286　2013/10

    Publisher: (NPO)日本高血圧学会

  14. トロピカミド・フェニレフリン塩酸塩液点眼による眼底血流への影響

    相澤 奈帆子, 國方 彦志, 新田 文彦, 阿部 俊明, 中澤 徹

    眼科臨床紀要　6　(10)　806-806　2013/10

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  15. レーザードップラー流速血流計とレーザースペックルフローグラフィーの相関

    浅野 俊文, 新田 文彦, 國方 彦志, 新家 眞, 中澤 徹

    眼科臨床紀要　6　(10)　806-807　2013/10

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  16. ペガプタニブ硝子体投与の眼循環血流に与える影響

    新田 文彦, 國方 彦志, 阿部 俊明, 中澤 徹

    眼科臨床紀要　6　(10)　834-834　2013/10

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  17. 無光覚に陥った加齢黄斑変性の背景に関する検討

    萱場 寛子, 阿部 俊明, 國方 彦志, 新田 文彦, 中澤 徹

    眼科臨床紀要　6　(9)　729-733　2013/09

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  18. 巨大裂孔網膜剥離に対するMIVSと20G硝子体手術の比較

    國方 彦志, 阿部 俊明, 新田 文彦, 安田 正幸, 玉井 洋, 相澤 奈帆子, 中澤 徹

    眼科臨床紀要　5　(10)　960-960　2012/10

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  19. 加齢黄斑変性症におけるラニビズマブ硝子体内投与前後の眼循環血流変化

    新田 文彦, 國方 彦志, 安田 正幸, 玉井 洋, 阿部 俊明, 中澤 徹

    眼科臨床紀要　5　(10)　976-977　2012/10

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  20. 東北大学病院における特発性傍中心窩毛細血管拡張症の特徴

    岡村 知世子, 國方 彦志, 新田 文彦, 阿部 俊明

    眼科臨床紀要　5　(10)　979-979　2012/10

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  21. 切迫早産に対するリトドイン塩酸塩静脈注射後に急性緑内障発作をきたしたプラトー虹彩緑内障の一例

    橋本 清香, 国松 志保, 小林 航, 新田 文彦, 目黒 泰彦, 中澤 徹

    日本緑内障学会抄録集　23回　142-142　2012/09

    Publisher: 日本緑内障学会

  22. 特発性黄斑円孔に対する硝子体手術成績とトリアムシノロンアセトニドの効果

    金澤 紘子, 國方 彦志, 安田 正幸, 新田 文彦, 鬼怒川 次郎, 阿部 俊明, 中澤 徹

    臨床眼科　66　(8)　1219-1224　2012/08

    Publisher: (株)医学書院

    ISSN： 0370-5579

    eISSN： 1882-1308

  23. レーザースペックルフローグラフィーLSFG-NAVI(non-mydriaticタイプ)の再現性

    相澤 奈帆子, 國方 彦志, 新田 文彦, 志賀 由己浩, 永富 良一, 牛 凱群, 中澤 徹

    日本眼科学会雑誌　116　(臨増)　304-304　2012/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  24. 健常人でのレーザースペックル(無散瞳タイプ)による眼循環血流の波形解析と年齢の検討

    新田 文彦, 國方 彦志, 永富 良一, 牛 凱軍, 玉井 洋, 阿部 俊明, 中澤 徹

    日本眼科学会雑誌　116　(臨増)　343-343　2012/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  25. 若年者外傷性黄斑円孔に対する硝子体手術後の長期予後

    雪田昌克, 國方彦志, 阿部俊明, 新田文彦, 中澤徹

    眼科手術　26　2012

    ISSN： 0914-6806

  26. 漿液性網膜剥離を伴う網膜血管腫にトリアムシノロンテノン嚢下注射が奏功した1例

    安田 正幸, 阿部 俊明, 國方 彦志, 鬼怒川 次郎, 新田 文彦

    眼科臨床紀要　4　(10)　1007-1007　2011/10

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  27. 25ゲージ硝子体手術におけるトロカールカニュラ挿入困難例の検討

    國方 彦志, 新田 文彦, 目黒 泰彦, 相澤 奈帆子, 針谷 威寛, 千葉 真生, 阿部 俊明, 西田 幸二

    眼科臨床紀要　4　(10)　1008-1008　2011/10

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  28. レーザースペックルフローグラフィを用いた光線力学療法後の血流解析

    新田 文彦, 國方 彦志, 中澤 徹, 鬼怒川 次郎, 安田 正幸, 阿部 俊明

    臨床眼科　65　(6)　863-868　2011/06

    Publisher: (株)医学書院

    ISSN： 0370-5579

    eISSN： 1882-1308

  29. 当院における増殖性糖尿病網膜症の悪化因子の検討

    鬼怒川 次郎, 國方 彦志, 阿部 俊明, 新田 文彦, 安田 正幸, 布施 昇男

    日本眼科学会雑誌　115　(臨増)　301-301　2011/04

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  30. 強度近視黄斑円孔に対する硝子体手術後の脈絡膜新生血管

    伊藤梓, 國方彦志, 安田正幸, 新田文彦, 阿部俊明, 中澤徹

    日本糖尿病眼学会総会講演抄録集　17th　2011

  31. 漿液性網膜剥離を伴う網膜血管腫にトリアムシノロンテノン嚢下注射が奏功した一例

    安田正幸, 阿部俊明, 國方彦志, 鬼怒川次郎, 新田文彦

    日本糖尿病眼学会総会講演抄録集　16th　2010

  32. 当院における外傷性肝損傷の検討

    久保田 洋介, 浅倉 毅, 高屋 潔, 大江 大, 佐山 淳造, 原田 雄功, 赤石 洋, 庄子 賢, 佐藤 章子, 三浦 禎司, 新田 文彦, 佐竹 洋平, 北原 祐, 酒井 信光

    仙台市立病院医学雑誌　25　37-41　2005/05

    Publisher: 仙台市立病院

    ISSN： 0388-8878

    More details Close

    1999年4月からの6年間に経験した外傷性肝損傷症例のうち,日本外傷学会肝損傷分類に明らかに画像上あてはまる84例を対象に受傷様式,外傷分類,治療法,合併損傷などについて臨床的検討を行った.Ib型が45%と最も多く,Ia型32%が多かった.受傷機転は交通事故が半数を占め,そのうちの60%程度がハンドル外傷によるものであった.高所作業中などの転落によるものも多かったが,自殺企図によるものもあった.合併損傷は56%に肺挫傷や骨盤骨折などが認められた.IIIa型,IIIb型では開腹手術は60%に要し,1例を除いて来院直後に手術が施行された.IIIb型での手術理由は全例が循環動態不安定であった.平均在院日数はIa型6.7日,Ib型17.3日,II型11.8日,IIIa型21.4日,IIIb型30日であった.歩行開始時期および食事開始時期もこの順で遅れる傾向が明らかにあった

  33. Solid-pseudopapillary tumorの2症例

    三浦 禎司, 佐山 淳造, 長沼 廣, 高屋 潔, 大江 大, 原田 雄功, 浅倉 毅, 赤石 洋, 庄子 賢, 久保田 洋介, 佐藤 章子, 佐竹 洋平, 新田 文彦, 酒井 信光

    仙台市立病院医学雑誌　25　95-100　2005/05

    Publisher: 仙台市立病院

    ISSN： 0388-8878

    More details Close

    Solid-pseudopapillary tumorの2症例を経験した.症例1は19歳女性で,上腹部不快感を初発症状とし,症例2は17歳女性で,上腹部腫瘤を契機に診断した.両例とも腹部エコーを含む画像検査が診断に有用で,摘出術を施行した.症例1は良性腫瘍と考えられたが,症例2では悪性が病理組織学的に考えられた

  34. 自然血気胸(特発性血気胸)の2例

    佐竹 洋平, 原田 雄功, 高屋 潔, 大江 大, 佐山 淳造, 浅倉 毅, 赤石 洋, 庄子 賢, 佐藤 章子, 三浦 禎司, 新田 文彦, 長沼 廣, 酒井 信光

    仙台市立病院医学雑誌　25　101-104　2005/05

    Publisher: 仙台市立病院

    ISSN： 0388-8878

    More details Close

    2例の自然気胸を経験した.症例1は28歳男性で,突然に右胸痛が生じたことを契機に近医にて緊張性気胸の診断にて18G針にて穿刺後に紹介され,保存的に加療することで第24病日に退院できた.症例2は29歳男性で,突然の胸痛の出現により救急車で来院し,気胸を認めトロッカーを挿入したところ血性気胸であることが判明し,胸部CTにて血胸が進行していることが確認できたため手術療法を行った

  35. 大量出血を伴った自然気胸の2症例

    佐竹 洋平, 原田 雄功, 高屋 潔, 大江 大, 佐山 淳造, 浅倉 毅, 赤石 洋, 庄子 賢, 只野 章子, 三浦 禎司, 新田 文彦, 北原 祐, 酒井 信光

    The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY　53　(Suppl.I)　22-22　2005/03

    Publisher: シュプリンガー・ジャパン(株)

    ISSN： 1344-4964

    eISSN： 1863-2092

  36. 内視鏡下に活動性出血が認められた大腸憩室出血の1例

    新田 文彦, 佐山 淳造, 高屋 潔, 大江 大, 原田 雅功, 浅倉 毅, 赤石 洋, 庄子 賢, 酒井 信光

    東北医学雑誌　116　(2)　168-168　2004/12

    Publisher: 東北医学会

    ISSN： 0040-8700

  37. 外傷性肝損傷における保存的治療の検討

    久保田 洋介, 浅倉 毅, 高屋 潔, 大江 大, 佐山 淳造, 原田 雄功, 赤石 洋, 庄子 賢, 三浦 禎司, 佐藤 章子, 佐竹 洋平, 新田 文彦, 酒井 信光

    東北医学雑誌　116　(2)　183-183　2004/12

    Publisher: 東北医学会

    ISSN： 0040-8700

  38. Solid-pseudopapillary tumorの2症例

    三浦 禎司, 佐山 淳造, 長沼 廣, 高屋 潔, 大江 大, 原田 雄功, 浅倉 毅, 赤石 洋, 庄子 賢, 久保田 洋介, 佐藤 章子, 新田 文彦, 佐竹 洋平, 酒井 信光

    東北医学雑誌　116　(2)　186-186　2004/12

    Publisher: 東北医学会

    ISSN： 0040-8700

  39. 外傷性頸動脈断裂の2例

    佐藤 馨, 大江 大, 高屋 潔, 原田 雄功, 佐山 淳造, 浅倉 毅, 赤石 洋, 庄子 賢, 三浦 禎司, 佐藤 章子, 佐竹 洋平, 新田 文彦, 酒井 信光

    日本血管外科学会雑誌　13　(6)　647-648　2004/10

    Publisher: (NPO)日本血管外科学会

    ISSN： 0918-6778

    eISSN： 1881-767X

  40. 橈骨動脈瘤の1例

    新田 文彦, 大江 大, 高屋 潔, 佐山 淳造, 原田 雄功, 浅倉 毅, 酒井 信光

    日本血管外科学会雑誌　12　(7)　674-674　2003/12

    Publisher: (NPO)日本血管外科学会

    ISSN： 0918-6778

    eISSN： 1881-767X

  41. 小児の虫垂カルチノイドの一例

    三浦 禎司, 浅倉 毅, 高屋 潔, 大江 大, 原田 雄功, 佐山 淳造, 加藤 丈人, 鈴木 洋, 只野 章子, 佐竹 洋平, 新田 文彦, 酒井 信光

    東北医学雑誌　115　(2)　190-190　2003/12

    Publisher: 東北医学会

    ISSN： 0040-8700

  42. 早期に再発した後腹膜腫の1例

    佐竹 洋平, 新田 文彦, 北原 祐, 三浦 禎司, 只野 章子, 鈴木 洋, 浅倉 毅, 加藤 丈人, 原田 雄功, 佐山 淳造, 大江 大, 高屋 潔, 酒井 信光

    東北医学雑誌　115　(2)　196-196　2003/12

    Publisher: 東北医学会

    ISSN： 0040-8700

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