Details of the Researcher

PHOTO

Shigekazu Sugino
Section
Tohoku University Hospital
Job title
Associate Professor
Degree

  • Ph.D. (Sapporo Medical University)

e-Rad No.
00423765
Profile
My mission is to produce the better anesthesiology research and care at the intersection of biomedical science and clinical practice.

Research History 13

  • 2023/04 - Present
    Tohoku University　Dept. of Anesthesiology and Perioperative Medicine　Associate Professor

  • 2019/11 - 2023/03
    Tohoku University　Dept. of Anesthesiology and Perioperative Medicine　Assistant Professor

  • 2015/07 - 2019/10
    Tohoku University　Dept. of Anesthesiology and Perioperative Medicine　Research Associate

  • 2013/05 - 2015/06
    Pennsylvania State University College of Medicine　Dept. of Anesthesiology and Perioperative Medicine　Visiting Research Asociate

  • 2010/04 - 2013/04
    Sapporo Medical University　Dept. of Anesthesiology　Research Associate

  • 2008/04 - 2010/03
    Otaru Municipal Hospital　Dept. of Anesthesia　Chief Anesthesiologist

  • 2004/10 - 2008/03
    Sapporo Medical University　Dept. of Anesthesiology　Postgraduate Student

  • 2003/04 - 2004/09
    Nikko Memorial Hospital　Dept. of Anesthesia　Staff Anesthesiologist

  • 2002/04 - 2003/03
    Sapporo Medical University　Dept. of Anesthesiology　Staff Anesthesiologist

  • 2001/04 - 2002/03
    Kitami Red Cross Hospital　Dept. of Anesthesia　Staff Anesthesiologist

  • 2000/04 - 2001/03
    Kushiro City General Hospital　Dept. of Anesthesia　Staff Anesthesiologist

  • 1999/03 - 2000/02
    Asahikawa City Hospital　Dept. of Anesthesia　Resident

  • 1998/04 - 1999/03
    Sapporo Medical University　Dept. of Anesthesiology　Resident

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Education 2

  • Sapporo Medical University　Graduate School of Medicine　Anesthesiology

    - 2008/03

  • Sapporo Medical University　School of Medicine

    - 1998/03

Professional Memberships 7

  • Japan Society for Clinical Anesthesia

  • European Society of Anaesthesiolgy and Intensive Care

  • AMERICAN SOCIETY OF HUMAN GENETICS

  • AMERICAN SOCIETY OF ANESTHESIOLOGISTS

  • SOCIETY FOR NEUROSCIENCE

  • THE JAPANESE SOCIETY OF INTENSIVE CARE MEDICINE

  • JAPANESE SOCIETY OF ANESTHESIOLOGISTS

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Research Interests 19

  • Mass Spectrometry

  • Genetic Polymorphism

  • Transcriptome

  • Awake Craniotomy

  • Neuroanesthesia

  • Rat Model of Pain

  • Acute Pain Service

  • Postoperative Pain

  • G-protein Coupling Receptor

  • Next-generation DNA Sequencer

  • Genome-wide Association Study

  • Chronic Post-surgical Pain

  • Omics

  • Suncus

  • Postoperative Nausea and Vomiting

  • Opioid

  • Perioperative Genetics and Genomics

  • Pain Medicine

  • Anesthesiology

Research Areas 1

  • Life sciences / Anesthesiology /

Awards 4

  1. Good Presentation Award

    2024/04　The 11th Annual Meeting of Japanese Regional Anesthesia Society　Pulsed radio-frequency with peripheral nerve block attenuates postoperative pain via Fyn tyrosine kinase expression.

  2. Best Presentation Award

    2019/09　JSA Hokkaido-Tohoku Branch 9th Annual Meeting　Effect of Dexmedetomidine on A Rat Model of Postoperative Nausea and Vomiting

  3. Best Presentation Award

    2005/05　The 58th Annual Meeting of Hokkaido Anesthesia Society (JSA Hokkaido-Tohoku Branch)　Strain differences in excitability of mouse RVM neuron in response to intracerebroventricular administration of DAMGO

  4. Best Research Award

    2005/03　Japanese Society for Abdominal Emergency Medicine　Transcatheter Arterial Embolization of Blunt Abdominal Trauma Patients in Remote Medical Area: A Case Series

Papers 61

  1. Antiemetic effects of baclofen in a shrew model of postoperative nausea and vomiting: Whole-transcriptome analysis in the nucleus of the solitary tract. International-journal Peer-reviewed

    Daisuke Konno, Shigekazu Sugino, Tomoko F Shibata, Kazuharu Misawa, Yuka Imamura-Kawasawa, Jun Suzuki, Kanta Kido, Masao Nagasaki, Masanori Yamauchi

    CNS neuroscience & therapeutics　28　(6)　922-931　2022/03/03

    DOI： 10.1111/cns.13823 　

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    AIMS: The molecular genetic mechanisms underlying postoperative nausea and vomiting (PONV) in the brain have not been fully elucidated. This study aimed to determine the changes in whole transcriptome in the nucleus of the solitary tract (NTS) in an animal model of PONV, to screen a drug candidate and to elucidate the molecular genetic mechanisms of PONV development. METHODS: Twenty-one female musk shrews were assigned into three groups: the Surgery group (shrew PONV model, n = 9), the Sham group (n = 6), and the Naïve group (n = 6). In behavioral studies, the main outcome was the number of emetic episodes. In genetic experiments, changes in the transcriptome in the NTS were measured. In a separate study, 12 shrews were used to verify the candidate mechanism underlying PONV. RESULTS: A median of six emetic episodes occurred in both the Sham and Surgery groups. Whole-transcriptome analysis indicated the inhibition of the GABAB receptor-mediated signaling pathway in the PONV model. Baclofen (GABAB receptor agonist) administration eliminated emetic behaviors in the shrew PONV model. CONCLUSIONS: Our findings suggest that the GABAB receptor-mediated signaling pathway is involved in emesis and that baclofen may be a novel therapeutic or prophylactic agent for PONV.

  2. Crucial involvement of catecholamine neurotransmission in postoperative nausea and vomiting: Whole-transcriptome profiling in the rat nucleus of the solitary tract Peer-reviewed

    Shigekazu Sugino, Daisuke Konno, Junko Abe, Yuka Imamura-Kawasawa, Kanta Kido, Jun Suzuki, Yasuhiro Endo, Masanori Yamauchi

    Genes, Brain and Behavior　20　(6)　e12759　2021/06

    DOI： 10.1111/gbb.12759 　

    ISSN： 1601-1848

    eISSN： 1601-183X

  3. Long non-coding RNA MIR4300HG polymorphisms are associated with postoperative nausea and vomiting: a genome-wide association study. International-journal Peer-reviewed

    Shigekazu Sugino, Daisuke Konno, Yosuke Kawai, Masao Nagasaki, Yasuhiro Endo, Tomo Hayase, Misako Yamazaki-Higuchi, Yukihiro Kumeta, Shunsuke Tachibana, Katsuhiko Saito, Jun Suzuki, Kanta Kido, Nahoko Kurosawa, Akiyoshi Namiki, Masanori Yamauchi

    Human genomics　14　(1)　31-31　2020/09/14

    DOI： 10.1186/s40246-020-00282-4 　

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    BACKGROUND: Genetic factors such as single-nucleotide polymorphisms (SNPs) play a key role in the development of postoperative nausea and vomiting (PONV). However, previous findings are not widely applicable to different populations because of population-specific genetic variation. We developed a Japanese-specific DNA microarray for high-throughput genotyping. The aim of the current study was to identify SNPs associated with PONV on a genome-wide scale using this microarray in a sample of Japanese surgical patients. METHODS: Associations between 659,636 SNPs and the incidence of PONV 24 h after surgery in a limited sample of 24 female patients were assessed using the microarray. After imputation of genotypes at 24,330,529 SNPs, 78 SNPs were found to be associated with the incidence of PONV. We chose 4 of the 78 SNPs to focus on by in silico functional annotation. Finally, we genotyped these 4 candidate SNPs in 255 patients using real-time PCR to verify association with the incidence of PONV. RESULTS: The T > C variant of rs11232965 in the long non-coding RNA MIR4300HG was significantly associated with reduced incidence of PONV among genotypes and between alleles (p = 0.01 and 0.007). CONCLUSIONS: We identified a novel SNP (rs11232965) in the long non-coding RNA MIR4300HG that is associated with PONV. The rs11232965-SNP variant (T > C) is protective against the incidence of PONV. TRIAL REGISTRATION: This study was registered at the UMIN Clinical Trials Registry (Identifier: UMIN000022903 , date of registration: June 27, 2016, retrospectively registered.

  4. Effect of forced-air warming by an underbody blanket on end-of-surgery hypothermia: a propensity score-matched analysis of 5063 patients. International-journal Peer-reviewed

    Hiroshi Sumida, Shigekazu Sugino, Norifumi Kuratani, Daisuke Konno, Jun-Ichi Hasegawa, Masanori Yamauchi

    BMC anesthesiology　19　(1)　50-50　2019/04/09

    DOI： 10.1186/s12871-019-0724-8 　

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    BACKGROUND: Underbody blankets have recently been launched and are used by anesthesiologists for surgical patients. However, the forced-air warming effect of underbody blankets is still controversial. The aim of this study was to determine the effect of forced-air warming by an underbody blanket on body temperature in anesthetized patients. METHODS: We retrospectively analyzed 5063 surgical patients. We used propensity score matching to reduce the bias caused by a lack of randomization. After propensity score matching, the change in body temperature from before to after surgery was compared between patients who used underbody blankets (Under group) and those who used other types of warming blankets (Control group). The incidence of hypothermia (i.e., body temperature < 36.0 °C at the end of surgery) was compared between the two groups. A p value < 0.05 was considered to indicate statistical significance. RESULTS: We obtained 489 propensity score-matched pairs of patients from the two groups, of whom 33 and 63 had hypothermia in the Under and Control groups, respectively (odds ratio: 0.49, 95% confidence interval: 0.31-0.76, p = 0.0013). CONCLUSIONS: The present study suggests that the underbody blanket may help reduce the incidence of intraoperative hypothermia and may be more efficient in warming anesthetized patients compared with other types of warming blankets. TRIAL REGISTRATION: UMIN Clinical Trials Registry (Identifier: UMIN000022909 ; retrospectively registered on June 27, 2016).

  5. Intraoperative auditory evoked potential recordings are more reliable at signal detection from different sensor sites on the forehead compared to bispectral index. International-journal Peer-reviewed

    Yoshiya Ishioka, Shigekazu Sugino, Tomo Hayase, Piotr K Janicki

    Journal of clinical monitoring and computing　31　(1)　117-122　2017/02

    DOI： 10.1007/s10877-015-9812-6 　

    ISSN： 1387-1307

    eISSN： 1573-2614

  6. Massive Fulminant Thrombosis During Liver Transplantation in a Patient With a Previously Unknown Antithrombin Pathway Mutation. International-journal Peer-reviewed

    Dmitri Bezinover, Shigekazu Sugino, Yuka Imamura-Kawasawa, Matthew S Bell, Zakiyah Kadry, Piotr K Janicki

    A & A case reports　7　(11)　239-242　2016/12/01

    DOI： 10.1213/XAA.0000000000000396 　

    eISSN： 2325-7237

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    We describe a case of fulminant intraoperative thrombosis during deceased donor liver transplantation. Despite significant medical bleeding, the patient suddenly developed diffuse thrombosis in all chambers of the heart and pulmonary vasculature resulting in intraoperative death. The patient's postmortem genetic analysis demonstrated a deleterious missense mutation in a coagulation pathway gene, SERPINC1, which codes for antithrombin III. The level of antithrombin III was not available to directly prove the causality of thrombosis, but our findings suggest that this mutation, in combination with antifibrinolytic administration in a hypercoagulable cirrhotic patient, might have contributed to the development of this catastrophic thrombotic event.

  7. Gα14 subunit-mediated inhibition of voltage-gated Ca2+ and K+ channels via neurokinin-1 receptors in rat celiac-superior mesenteric ganglion neurons. International-journal Peer-reviewed

    Shigekazu Sugino, Mohamed Farrag, Victor Ruiz-Velasco

    Journal of neurophysiology　115　(3)　1577-86　2016/03

    DOI： 10.1152/jn.00980.2015 　

    ISSN： 0022-3077

    eISSN： 1522-1598

  8. Efficacy and Safety of a Lidocaine and Ropivacaine Mixture for Scalp Nerve Block and Local Infiltration Anesthesia in Patients Undergoing Awake Craniotomy. International-journal Peer-reviewed

    Tomohiro Chaki, Shigekazu Sugino, Piotr K Janicki, Yoshiya Ishioka, Yosuke Hatakeyama, Tomo Hayase, Miki Kaneuchi-Yamashita, Naonori Kohri, Michiaki Yamakage

    Journal of neurosurgical anesthesiology　28　(1)　1-5　2016/01

    DOI： 10.1097/ANA.0000000000000149 　

    ISSN： 0898-4921

    eISSN： 1537-1921

  9. Peripartum Anesthetic Management and Genomic Analysis of Rare Variants in a Patient with Familial Pulmonary Fibrosis. International-journal Peer-reviewed

    Shigekazu Sugino, Brandon J Bortz, Sonia Vaida, Kunal Karamchandani, Piotr K Janicki

    A & A case reports　5　(10)　169-72　2015/11/15

    DOI： 10.1213/XAA.0000000000000198 　

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    A 29-year-old patient, 32 weeks' pregnant, with a history of familial interstitial fibrosis, was treated for acute hypoxemia after admission to the intensive care unit. Within 48 hours, this was followed by an emergent cesarean delivery, under general anesthesia, due to acute respiratory failure. Successful perinatal obstetric and anesthetic management resulted in the delivery of a baby and recovery of the mother. Subsequent genomic analysis using next-generation sequencing of the patient's entire exome revealed that she was a carrier of a deleterious mutation in the TERT gene, previously associated with the hereditary forms of interstitial fibrosis.

  10. TACR1 gene polymorphism and sex differences in postoperative nausea and vomiting Peer-reviewed

    T. Hayase, S. Sugino, H. Moriya, M. Yamakage

    ANAESTHESIA　70　(10)　1148-1159　2015/10

    DOI： 10.1111/anae.13082 　

    ISSN： 0003-2409

    eISSN： 1365-2044

  11. Pharmacogenetics of chemotherapy-induced nausea and vomiting. International-journal Peer-reviewed

    Shigekazu Sugino, Piotr K Janicki

    Pharmacogenomics　16　(2)　149-60　2015/01

    DOI： 10.2217/pgs.14.168 　

    ISSN： 1462-2416

    eISSN： 1744-8042

  12. Association of μ-opioid receptor gene (OPRM1) haplotypes with postoperative nausea and vomiting. International-journal Peer-reviewed

    Shigekazu Sugino, Tomo Hayase, Misako Higuchi, Katsuhiko Saito, Hiroyuki Moriya, Yukihiro Kumeta, Nahoko Kurosawa, Akiyoshi Namiki, Piotr K Janicki

    Experimental brain research　232　(8)　2627-35　2014/08

    DOI： 10.1007/s00221-014-3987-9 　

    ISSN： 0014-4819

    eISSN： 1432-1106

  13. Genetic factors associated with pharmacotherapy and background sensitivity to postoperative and chemotherapy-induced nausea and vomiting. International-journal Peer-reviewed

    Piotr K Janicki, Shigekazu Sugino

    Experimental brain research　232　(8)　2613-25　2014/08

    DOI： 10.1007/s00221-014-3968-z 　

    ISSN： 0014-4819

    eISSN： 1432-1106

  14. Improved non-invasive total haemoglobin measurements after in-vivo adjustment Peer-reviewed

    R. Miyashita, N. Hirata, S. Sugino, M. Mimura, M. Yamakage

    ANAESTHESIA　69　(7)　752-756　2014/07

    DOI： 10.1111/anae.12681 　

    ISSN： 0003-2409

    eISSN： 1365-2044

  15. Genetic differences in response properties of rostral ventromedial medulla neurons to the μ-opioid receptor agonist DAMGO in mouse inbred strains. International-journal Peer-reviewed

    Shigekazu Sugino, Akiyoshi Namiki, Michiaki Yamakage

    Neuroscience letters　517　(2)　107-12　2012/05/31

    DOI： 10.1016/j.neulet.2012.04.038 　

    ISSN： 0304-3940

  16. Forehead is as sensitive as finger pulse oximetry during general anesthesia. International-journal Peer-reviewed

    Shigekazu Sugino, Noriaki Kanaya, Masahito Mizuuchi, Masayasu Nakayama, Akiyoshi Namiki

    Canadian journal of anaesthesia = Journal canadien d'anesthesie　51　(5)　432-6　2004/05

    DOI： 10.1007/BF03018304 　

    ISSN： 0832-610X

  17. Postoperative delirium is associated with increased long-term mortality following oral and maxillofacial reconstructive surgery

    Y. Nitta, T. Sanuki, S. Sugino, M. Sugimoto, K. Kido

    International Journal of Oral and Maxillofacial Surgery　2025/09

    Publisher: Elsevier BV

    DOI： 10.1016/j.ijom.2025.09.007 　

    ISSN： 0901-5027

  18. Neuropathic pain after peripheral nerve injury in rats: a model using sciatic nerve clamping. Peer-reviewed

    Michio Kumagai, Shigekazu Sugino, Toru Murakami, Hideaki Obata, Masanori Yamauchi

    Journal of anesthesia　2025/08/02

    DOI： 10.1007/s00540-025-03541-7 　

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    Various preclinical rodent models have been established and utilized to elucidate the mechanisms underlying neuropathic pain. However, the utility of existing major models faces challenges, such as reproducibility and surgical complexity. Here, we introduce a new rat model of neuropathic pain created by simply clamping the sciatic nerve for 10 min. First, we investigated pain-related behavior in 12 male Wistar rats after surgery to clamp the sciatic nerve that induced mechanical allodynia for 21 days and thermal hyperalgesia for 7 days (2-way ANOVA compared with sham-operated rats, p < 0.01). We observed only small interindividual differences in response to stimuli among the rats after sciatic nerve clamp surgery. The L5 dorsal root ganglion and spinal dorsal horn of the other 14 rats were subsequently sectioned and stained for Atf3 and Iba-1 immunoreactivity, respectively. Compared with sham surgery, nerve clamping induced peripheral and central sensitization (Mann-Whitney U test, p < 0.01). This new preclinical rat model of neuropathic pain offers procedural simplicity and high reproducibility.

  19. Analgesic efficacy and serum ropivacaine concentration of postoperative programmed intermittent bolus infusion with serratus anterior plane block in patients undergoing minimally invasive cardiac surgery: A randomized, double-blind, controlled trial. Peer-reviewed

    Yuna Sato, Michio Kumagai, Yu Kaiho, Shigekazu Sugino, Tomohiro Sekine, Masataka Taguri, Hiroshi Inoue, Jun Ito, Yu Sato, Toshihiro Sato, Masamitsu Maekawa, Masanori Yamauchi

    Journal of anesthesia　2025/07/01

    DOI： 10.1007/s00540-025-03536-4 　

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    PURPOSE: Minimally invasive cardiac surgery (MICS) involves fewer complications than median sternotomy. However, difficulties in post-MICS analgesia can undermine these advantages. The serratus anterior plane block (SAPB), an effective analgesic for thoracic surgery, could benefit post-MICS analgesia using programmed intermittent bolus infusion (PIBI). We investigated whether PIBI with SAPB can reduce post-MICS fentanyl administration and evaluated its safety profile. METHODS: This randomized, double-blind, controlled trial included 20 patients (age 20-80 years; Eastern Cooperative Oncology Group Performance Status 0-II; scheduled for elective MICS) randomly allocated to two groups (SAPB or control). All patients underwent preoperative SAPB with catheterization, followed by either 20 mL 0.25% ropivacaine or saline bolus every 6 h postoperatively. All patients received intravenous fentanyl via patient-controlled analgesia. Blood samples were collected 10, 20, 30, and 60 min after preoperative ropivacaine infusion; during and after cardiopulmonary bypass; and on postoperative days 1-5. The primary outcome was cumulative fentanyl consumption up to postoperative day 5. Secondary outcomes included numerical rating scale scores, rehabilitation preoperatively and postoperatively, postoperative nausea and vomiting, ropivacaine toxicity, and PIBI with SAPB complications. RESULTS: After excluding three patients, data from 17 patients were analyzed. No significant difference in cumulative fentanyl consumption on postoperative day 5 was observed (SAPB: median [interquartile range], 512 µg [457-753] vs. control: 654 µg [439-982], P = 0.96). Serum ropivacaine concentration remained below the toxicity threshold. CONCLUSION: PIBI with SAPB did not reduce post-MICS fentanyl consumption, and serum ropivacaine concentration did not reach the toxicity threshold.

  20. Clinical, ethnic and genetic risk factors associated with postoperative nausea and vomiting in patients undergoing cancer surgery: a case-control study. International-journal Peer-reviewed

    Thiago Ramos Grigio, Tatiane Katsue Furuya, Alexandre Slullitel, Alexis Germán Murillo Carrasco, Miyuki Uno, Maria José Ferreira Alves, Maria José Carvalho Carmona, Shigekazu Sugino, Roger Chammas, Angela Maria Sousa

    American journal of translational research　17　(4)　3235-3246　2025

    DOI： 10.62347/DGRM3907 　

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    OBJECTIVES: To identify the clinical, ethnic, and genetic factors contributing to the varying risks of postoperative nausea and vomiting (PONV) among a Brazilian population undergoing cancer surgery. METHODS: A case-control study was conducted involving 152 patients who experienced vomiting and/or retching (cases) and 158 patients who did not report nausea, vomiting, or retching (controls) within 24 h following oncological surgeries. This study is registered as 'Genetic Polymorphism and postoperative nausea and vomiting (PONV)' under registration number NCT03627780 (https://clinicaltrials.gov/study/NCT03627780). Thirty-two polymorphisms associated with PONV predisposition and 15 polymorphisms for ancestry analysis were genotyped via real-time polymerase chain reaction (PCR) with customised TaqMan low-density array (TLDA) cards. RESULTS: The C allele of the rs208294 polymorphism (P2RX7 gene) was observed at a significantly higher rate in the control group than in the case group across the genotype (P=0.035), dominant (P=0.010) and allele (0.032) models, thus suggesting a protective effect against PONV. The genotype results for rs208294 were validated via Sanger sequencing, which confirmed the association in the dominant model (P=0.027). In a multivariate regression analysis that included rs208294 and clinical variables that were identified in the univariate analysis, only a prior history of PONV or motion sickness was observed to be a significant predictor of PONV (P<0.05). No association between rs208294 and PONV was detected in an external cohort consisting of 198 cases and 56 controls of Japanese descents (P>0.05). Additionally, ancestry analysis indicated a predominantly European genetic composition in the Brazilian cohort, which differed with the Asian composition of the independent validation cohort. CONCLUSIONS: A previous history of PONV or motion sickness was identified as being the strongest predictor of PONV in our analysis. Genetic association, ancestry and external validation analyses suggest that genetic factors for PONV may significantly differ across populations of different continental origins.

  21. The Impact of Preoperative Psychiatric Intervention for Postoperative Delirium after Major Oral and Maxillofacial Surgery with Free Flap Reconstruction. International-journal Peer-reviewed

    Yukie Nitta, Takuro Sanuki, Shigekazu Sugino, Masahiro Sugimoto, Kanta Kido

    Journal of stomatology, oral and maxillofacial surgery　102026-102026　2024/08/30

    DOI： 10.1016/j.jormas.2024.102026 　

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    BACKGROUND: Postoperative delirium (POD) is a severe complication associated with various adverse outcomes, especially in older patients. Although the incidence and risk factors for POD have been explored in general surgery, they have not been fully elucidated. Early identification of high-risk patients and active preoperative intervention are considered essential for the prevention of POD. Recently, psychiatric consultation intervention have been shown to prevent delirium. This study investigated the effect of preoperative psychiatric interventions on preventing POD in our specific surgical context. MATERIALS AND METHODS: This retrospective, single-center observational study included 86 patients who underwent major oral and maxillofacial surgery with free flap reconstruction between 2016 and 2023. The effect of psychiatric intervention were compared between patients with and without delirium. RESULTS: Preoperative psychiatric intervention did not reduce the incidence of POD. The incidence of POD was 29.1%. Univariate analyses showed no significant associations between POD and any clinical variables. CONCLUSION: There was no difference in the incidence of POD between patients who received preoperative psychiatric intervention and those who did not, and further investigation is needed to determine the efficacy of preoperative psychiatric intervention in the prevention of POD.

  22. Acanthopanax senticosus ameliorates steatohepatitis through HNF4 alpha pathway activation in mice. International-journal Peer-reviewed

    Yutaka Kawano, Maki Tanaka, Yasushi Satoh, Shigekazu Sugino, Jun Suzuki, Masaki Fujishima, Eri Okumura, Hideo Takekoshi, Osamu Uehara, Shintaro Sugita, Yoshihiro Abiko, Tetsu Tomonari, Hironori Tanaka, Hidekatsu Takeda, Tetsuji Takayama

    Scientific reports　14　(1)　110-110　2024/01/02

    DOI： 10.1038/s41598-023-50625-z 　

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    Non-alcoholic fatty liver disease is a common liver disease worldwide, and is associated with dysregulation of lipid metabolism, leading to inflammation and fibrosis. Acanthopanax senticosus Harms (ASH) is widely used in traditional medicine as an adaptogen food. We examined the effect of ASH on steatohepatitis using a high-fat diet mouse model. Mice were fed a choline-deficient, L-amino acid-defined, high-fat diet with ASH extract (ASHE). After 6 weeks, liver RNA transcriptome sequencing (RNA-Seq) was performed, followed by Ingenuity Pathway Analysis (IPA). Our findings revealed that mice fed a high-fat diet with 5% ASHE exhibited significantly reduced liver steatosis. These mice also demonstrated alleviated inflammation and reduced fibrosis in the liver. IPA of RNA-Seq indicated that hepatocyte nuclear factor 4 alpha (HNF4 alpha), a transcription factor, was the activated upstream regulator (P-value 0.00155, z score = 2.413) in the liver of ASHE-fed mice. Adenosine triphosphate binding cassette transporter 8 and carboxylesterase 2, downstream targets of HNF4 alpha pathway, were upregulated. Finally, ASHE-treated HepG2 cells exposed to palmitate exhibited significantly decreased lipid droplet contents. Our study provides that ASHE can activate HNF4 alpha pathway and promote fat secretion from hepatocytes, thereby serving as a prophylactic treatment for steatohepatitis in mice.

  23. Quantification of muscle tone by using shear wave velocity during an anaesthetic induction: a prospective observational study. International-journal Peer-reviewed

    Hidehisa Saito, Shigekazu Sugino, Shoichiro Moteki, Akihiro Kanaya, Masanori Yamauchi

    BMC anesthesiology　23　(1)　388-388　2023/11/29

    DOI： 10.1186/s12871-023-02358-9 　

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    OBJECTIVES: The quantitative assessment of muscle stiffness or weakness is essential for medical care. Shear wave elastography is non-invasive ultrasound method and provides quantitative information on the elasticity of soft tissue. However, the universal velocity scale for quantification has not been developed. The aim of the study is to determine the shear wave velocities of abdominal muscle during anesthetic induction and to identify methods to cancel the effects of confounders for future development in the quantitative assessment of muscle tone using the universal scale. METHODS: We enrolled 75 adult patients undergoing elective surgery with ASA-PS I - III in the period between December 2018 and March 2021. We measured and calculated the shear wave velocity (SWV) before and after opioid administration (i.e., the baseline at rest and opioid-induced rigidity condition), and after muscle relaxant administration (i.e., zero reference condition). The SWV value was adjusted for the subcutaneous fat thickness by our proposed corrections. The SWVs after the adjustment were compared among the values in baseline, rigidity, and relaxation using one-way repeated-measures ANOVA and post hoc Tukey-Kramer test. A p-value of < 0.05 was considered to be statistically significant. UMIN Clinical Trials Registry identifier UMIN000034692, registered on October 30, 2018. RESULTS: The SWVs in the baseline, opioid-induced rigidity, and muscle relaxation conditions after the adjustment were 2.08 ± 0.48, 2.41 ± 0.60, and 1.79 ± 0.30 m/s, respectively (p < 0.001 at all comparisons). CONCLUSION: The present study suggested that the SWV as reference was 1.79 m/s and that the SWVs at rest and opioid-induced rigidity were ~ 10% and ~ 30% increase from the reference, respectively. The SWV adjusted for the subcutaneous fat thickness may be scale points for the assessment of muscle tone.

  24. Circulating Extracellular Vesicle Levels in Patients with Coronavirus Disease 2019 Coagulopathy: A Prospective Cohort Study. International-journal Peer-reviewed

    Yudai Iwasaki, Yusuke Takei, Mitsuhiro Yamada, Shigekazu Sugino, Koji Saito, Tetsuji Aoyagi, Kengo Oshima, Hajime Kanamori, Hiroaki Baba, Kentarou Takei, Koichi Tokuda, Eichi N Kodama, Tetsuro Kamo, Tadashi Kamio, Takehiko Kasai, Satoru Ogawa, Masanori Yamauchi

    Journal of clinical medicine　12　(10)　2023/05/14

    DOI： 10.3390/jcm12103460 　

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    Coronavirus disease 2019 (COVID-19) is associated with coagulopathy. However, the underlying mechanisms are not completely understood. We evaluated the association between COVID-19 coagulopathy and extracellular vesicle (EV) levels. We hypothesized that several EV levels would be higher in COVID-19 coagulopathy patients than in non-coagulopathy patients. This prospective observational study was conducted in four tertiary care faculties in Japan. We enrolled 99 COVID-19 patients (48 with coagulopathy and 51 without coagulopathy) aged ≥20 years who required hospitalization, and 10 healthy volunteers; we divided the patients into coagulopathy and non-coagulopathy groups according to the D-dimer levels (≥1 μg/mL and <1 μg/mL, respectively). We used flow cytometry to measure the tissue-factor-bearing, endothelium-derived, platelet-derived, monocyte-derived, and neutrophil-derived EV levels in platelet-free plasma. The EV levels were compared between the two COVID-19 groups as well as among the coagulopathy patients, non-coagulopathy patients, and healthy volunteers. No significant difference was found in EV levels between the two groups. Meanwhile, the cluster of differentiation (CD) 41 + EV levels were significantly higher in COVID-19 coagulopathy patients than in healthy volunteers (549.90 [255.05-984.65] vs. 184.3 [150.1-254.1] counts/µL, p = 0.011). Therefore, CD41+ EVs might play an essential role in COVID-19 coagulopathy development.

  25. Successful recording of direct cortical motor-evoked potential from a pediatric patient under remimazolam anesthesia: a case report Peer-reviewed

    Kotoe Kamata, Suguru Asagi, Yoshiteru Shimoda, Masayuki Kanamori, Nozomu Abe, Shigekazu Sugino, Teiji Tominaga, Masanori Yamauchi

    JA Clinical Reports　8　(1)　2022/08/22

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s40981-022-00555-y 　

    eISSN： 2363-9024

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    Abstract Background Intraoperative motor-evoked potential (MEP) monitoring reduces postoperative motor deficits. Propofol-based total intravenous anesthesia is the gold standard for intraoperative myogenic MEPs. Although there is no contraindication to administering propofol in adults with peanut, soy, or egg allergies, its safety in children with these allergies remains unclear. Case presentation A 12-year-old girl required general anesthesia under intraoperative direct cortical MEP (dc-MEP) monitoring due to supratentorial glioma. Remimazolam-based anesthesia was selected, instead of propofol, due to the patient’s egg hypersensitivity. Stable myogenic MEPs were recorded throughout the surgery with remimazolam at 0.9 mg/kg/h and remifentanil at 0.35 μg/kg/min, following adjustments of stimulation intensity and titration of remimazolam infusion. Neither intraoperative memory nor motor deficits were present after surgery. Conclusions We present a pediatric case whose dc-MEP was recorded under remimazolam anesthesia. The cardiovascular stability and avoidance of propofol infusion syndrome with remimazolam were superior to propofol.

  26. Evaluation of contrast-enhanced ultrasonography with Sonazoid® in visualization of local anesthetic distribution in rectus sheath block: a prospective, clinical study. Peer-reviewed

    Eiko Onishi, Kazutomo Saito, Michio Kumagai, Ruri Oba, Toru Murakami, Shigekazu Sugino, Masanori Yamauchi

    Journal of anesthesia　36　(3)　405-412　2022/04/26

    DOI： 10.1007/s00540-022-03063-6 　

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    PURPOSE: Clear visualization of ultrasound (US) images is crucial for successful US-guided nerve block. However, accurate determination of local anesthetic (LA) distribution from US images remains difficult. Sonazoid®, which comprises perflubutane microbubbles, is used to diagnose hepatic and breast tumors. This study aimed to investigate the visibility of Sonazoid® in perioperative US-guided nerve block. METHODS: We performed rectus sheath block (RSB) in patients scheduled for laparoscopic abdominal surgery (n = 10). 10 mL of a mixture containing equal amounts of 0.75% ropivacaine and iohexol with the addition of Sonazoid® diluted 100-fold was administered. We investigated the correlation and agreement between Sonazoid® and iohexol distributions. The brightness of the solution and tissues was calculated: a grayscale value between 0 (dark) and 255 (bright) was measured in all pixels of the region of interest. Adverse events were also investigated. RESULTS: Sonazoid® was clearly visualized and distinguished from the surrounding tissues both during and after RSB. The spread of Sonazoid® and iohexol was significantly correlated (spearman's ρ = 0.53, p = 0.0004). Bland-Altman analyses revealed significant mean difference between two methods (15.6 mm; 95% confidence interval [CI]: 10.6, 20.6; standard deviation (SD) 15.65; p < 0.0001). Limits of agreement were - 14.94 to 46.24 mm. Sonazoid® significantly increased the mean grayscale values at the posterior rectus sheath (93.7 vs. 201.9, p < 0.0001). There were no complications. CONCLUSION: Sonazoid diluted 100-fold® was clearly visualized real-time, and the enhancement was sustained and measurable after RSB. Sonazoid® could potentially be used for the contrast agent of US-guided nerve block.

  27. Effects of oxytocin on responses to nociceptive and non-nociceptive stimulation in the upper central nervous system. International-journal Peer-reviewed

    Hidehisa Saito, Shizu Hidema, Ayano Otsuka, Jun Suzuki, Michio Kumagai, Akihiro Kanaya, Toru Murakami, Yusuke Takei, Kazutomo Saito, Shigekazu Sugino, Hiroaki Toyama, Ryuta Saito, Teiji Tominaga, Katsuhiko Nishimori, Masanori Yamauchi

    Biochemical and biophysical research communications　574　8-13　2021/10/15

    DOI： 10.1016/j.bbrc.2021.08.042 　

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    Oxytocin is known as a social bonding hormone, but it also functions as an anxiolytic or analgesic neurotransmitter. When oxytocin regulates pain or anxiousness centrally as a neurotransmitter, it is secreted by neurons and directly projected to targeted regions. Although the function of oxytocin at the spinal level is well studied, its effects at the supraspinal level are poorly understood. We aimed to investigate the effect of oxytocin at the supraspinal level in vivo using C57BL/6J (wild-type [WT]), oxytocin-deficient (Oxt-/-), oxytocin receptor-deficient (Oxtr-/-), and oxytocin receptor-Venus (OxtrVenus/+) mice lines. Response thresholds in Oxtr-/- mice in Hargreaves and von-Frey tests were significantly lower than those in WT mice, whereas open field and light/dark tests showed no significant differences. Moreover, response thresholds in Oxt-/- mice were raised to those in WT mice after oxytocin administration. Following the Hargreaves test, we observed the co-localisation of c-fos with Venus or the oxytocin receptor in the periaqueductal gray (PAG), medial amygdala (MeA), and nucleus accumbens (NAc) regions in OxtrVenus/+ mice. Furthermore, in the PAG, MeA, and NAc regions, the co-localisation of oxytocin with c-fos and gamma-aminobutyric acid was much stronger in Oxtr-/- mice than in WT mice. However, following von-Frey test, the same findings were observed only in the MeA and NAc regions. Our results suggest that oxytocin exerts its analgesic effect on painful stimulation via the PAG region and a self-protective effect on unpleasant stimulation via the MeA and NAc regions.

  28. Nociceptive Sensitization by Activation of Protease-Activated Receptor 2 in a Rat Model of Incisional Pain. International-journal Peer-reviewed

    Kanta Kido, Norika Katagiri, Hiromasa Kawana, Shigekazu Sugino, Masanori Yamauchi, Eiji Masaki

    Brain sciences　11　(2)　2021/01/22

    DOI： 10.3390/brainsci11020144 　

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    Postoperative pain and consequent inflammatory responses after tissue incision adversely affects many surgical patients due to complicated mechanisms. In this study, we examined whether activation of protease-activated receptor 2 (PAR-2), which is stimulated by tryptase from mast cells, elicits nociception and whether the PAR-2 antagonist could reduce incisional nociceptive responses in vivo and in vitro. The effects of a selective PAR-2 antagonist, N3-methylbutyryl-N-6-aminohexanoyl-piperazine (ENMD-1068), pretreatment on pain behaviors were assessed after plantar incision in rats. The effects of a PAR-2 agonist, SLIGRL-NH2, on nociception was assessed after the injection into the hind paw. Furthermore, the responses of C-mechanosensitive nociceptors to the PAR-2 agonist were observed using an in vitro skin-nerve preparation as well. Intraplantar injection of SLIGRL-NH2 elicited spontaneous nociceptive behavior and hyperalgesia. Local administration of ENMD-1068 suppressed guarding behaviors, mechanical and heat hyperalgesia only within the first few hours after incision. SLIGRL-NH2 caused ongoing activity in 47% of C-mechanonociceptors in vitro. This study suggests that PAR-2 may support early nociception after incision by direct or indirect sensitization of C-fibers in rats. Moreover, PAR-2 may play a regulatory role in the early period of postoperative pain together with other co-factors to that contribute to postoperative pain.

  29. Effects of magnesium sulfate administration in attenuating chronic postsurgical pain in rats. International-journal Peer-reviewed

    Kanta Kido, Norika Katagiri, Hiromasa Kawana, Shigekazu Sugino, Daisuke Konno, Jun Suzuki, Masanori Yamauchi, Takuro Sanuki

    Biochemical and biophysical research communications　534　395-400　2021/01/01

    DOI： 10.1016/j.bbrc.2020.11.069 　

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    Chronic postsurgical pain (CPSP) is a serious issue for many postoperative patients. Though there are numerous treatment options for the prevention of CPSP, none of them is optimal as the mechanisms of the transition from acute to chronic postoperative pain have not been elucidated. Ketamine and opioids have been administered for chronic postoperative pain treatment but induce severe adverse reactions and/or physical dependency. Here, we examined whether pre-administration of the nonselective N-methyl-d-aspartate (NMDA) receptor antagonist magnesium sulfate attenuates CPSP behavior and alters the expression of glutamate ionotropic receptor NMDA type subunit 1a (Grin1 mRNA) in a rat skin/muscle incision and retraction (SMIR) model. We assessed the effects of a single subcutaneous magnesium sulfate injection on nociceptive behaviors including guarding pain, mechanical hyperalgesia, and heat hypersensitivity in rats after SMIR surgery. We used reverse transcription-quantitative PCR (RT-qPCR) to evaluate Grin1 mRNA expression in the dorsal horn of the spinal cord on postoperative day 14. Compared with the vehicle, magnesium sulfate administration before SMIR surgery reduced mechanical hyperalgesia for 17 d Grin1 gene expression was significantly higher on the ipsilateral side than the contralateral side (P = 0.001) on postoperative day 14. The magnesium sulfate injection prevented Grin1 mRNA upregulation in the spinal cord dorsal horn. A single magnesium sulfate injection mitigated SMIR-induced mechanical hyperalgesia possibly by modulating Grin1 expression. Preoperative magnesium sulfate administration could prove to be a simple and safe CPSP treatment.

  30. Postoperative Pain Management in Patients With Ulcerative Colitis. International-journal Peer-reviewed

    Norika Katagiri, Ryutaro Sakai, Takashi Izutsu, Hiromasa Kawana, Shigekazu Sugino, Kanta Kido

    Anesthesia progress　67　(3)　158-163　2020/09/01

    DOI： 10.2344/anpr-67-01-06 　

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    Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders of the gastrointestinal tract including ulcerative colitis (UC) and Crohn's disease. Pain management can be challenging in patients with IBD because there are limitations on the use of analgesics. Use of nonsteroidal anti-inflammatory drugs is not recommended in patients with IBD because there is risk of relapse of IBD and an overall increase in disease activity. Opioids, although frequently used for treating severe acute pain, can have additional risks and complications in patients with IBD such as ileus, toxic megacolon, and narcotic bowel syndrome. Furthermore, little information is available in the literature on pain management in these patients undergoing noncolorectal surgery. This report describes 2 patients with UC in whom postoperative pain following oral and maxillofacial surgery was managed by intravenous patient-controlled analgesia with pentazocine. Apart from the development of acute dystonia in 1 case that was likely due to the use of droperidol for prevention of postoperative nausea and vomiting, postoperative pain was well controlled by pentazocine in both patients without any complications or UC exacerbations.

  31. Successful management of an infant with hypertensive heart failure associated with Wilms' tumor: a case report. International-journal Peer-reviewed

    Hiroko Miura, Shin Kawana, Shigekazu Sugino, Chika Kikuchi, Masanori Yamauchi

    JA clinical reports　6　(1)　12-12　2020/02/13

    DOI： 10.1186/s40981-020-00318-7 　

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    BACKGROUND: Wilms' tumor with hyperreninemia may result in critical cardiovascular decompensation. We report a case of severe hypertensive heart failure followed by tumor resection in a 3-month-old infant with Wilms' tumor. CASE PRESENTATION: A 3-month-old girl was admitted to the intensive care unit for Wilms' tumor with hypertension and hypoxia. Her systolic blood pressure was 110 mmHg, and her SpO2 was 92%. She presented with severe hypertensive heart failure and received mechanical ventilation and antihypertensive therapy for hypertension and heart failure. An alpha 2-adrenergic receptor agonist was used for sedation as part of her antihypertensive therapy. On hospital day 16, nephrectomy with tumor resection was performed under general anesthesia. Her systolic blood pressure did not vary more than 20 mmHg during surgery due to appropriate preoperative management. Hemodynamic collapse did not occur. CONCLUSIONS: The highlight of this case report is the successful management of an infant with Wilms' tumor, particularly with respect to preoperative hemodynamic control and sedation.

  32. Increased burden of rare deleterious variants of the KCNQ1 gene in patients with large‑vessel ischemic stroke. International-journal Peer-reviewed

    Piotr K Janicki, Ceren Eyileten, Victor Ruiz-Velasco, Justyna Pordzik, Anna Czlonkowska, Iwona Kurkowska-Jastrzebska, Shigekazu Sugino, Yuka Imamura Kawasawa, Dagmara Mirowska-Guzel, Marek Postula

    Molecular medicine reports　19　(4)　3263-3272　2019/04

    DOI： 10.3892/mmr.2019.9987 　

    ISSN： 1791-2997

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    The impact of rare and damaging variants in genes associated with platelet function in large‑vessel ischemic stroke (LVIS) remains unknown. The aim of this study was to investigate the contribution of some of these variants to the genetic susceptibility to LVIS in Polish patients using a deep re‑sequencing of 54 selected genes, coding for proteins associated with altered platelet function. Targeted pooled re‑sequencing (Illumina HiSeq 2500) was performed on genomic DNA of 500 cases (patients with history of clinically proven diagnosis of LVIS) and 500 age‑, smoking status‑, and sex‑matched controls (no history of any type of stroke), and from the same population as patients with LVIS. After quality control and prioritization based on allele frequency and damaging probability, individual genotyping of all deleterious rare variants was performed in patients from the original cohort, and stratified to concomitant cardiac conditions differing between the study and stroke groups. We demonstrated a statistically significant increase in the number of rare and potentially damaging variants in some of the investigated genes in the LVIS pool (an increase in the genomic variants burden). Furthermore, we identified an association between LVIS and 6 rare functional and damaging variants in the Kv7.1 potassium channel gene (KCNQ1). The predicted functional properties (partial loss‑of function) for the three most damaging variants in KCNQ1 coding locus were further confirmed in vitro by analyzing the membrane potential changes in cell lines co‑transfected heterogeneously with human muscarinic type 1 receptor and wild‑type or mutated KCNQ1 cDNA constructs using fluorescence imaging plate reader. The study demonstrated an increased rare variants burden for 54 genes associated with platelet function, and identified a putative role for rare damaging variants in the KCNQ1 gene on LVIS susceptibility in the Polish population.

  33. Acute Management of Massive Epistaxis After Nasotracheal Extubation. International-journal Peer-reviewed

    Kanta Kido, Yuki Shindo, Hitoshi Miyashita, Mikio Kusama, Shigekazu Sugino, Eiji Masaki

    Anesthesia progress　66　(4)　211-217　2019

    DOI： 10.2344/anpr-66-02-09 　

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    Epistaxis is one of the most common complications of nasotracheal intubation and can be life-threatening. However, there is little discussion in the current literature on the acute management of massive epistaxis after nasotracheal extubation. This is a report of 2 patients who experienced severe unanticipated nasal bleeding immediately after extubation, 1 after a surgical procedure for oral cancer and another after restorative dental treatment. In both cases the significant epistaxis was managed successfully with a Foley balloon catheter used to pack the posterior nasal cavity. The Foley catheter technique may be useful for managing and arresting sudden postextubation epistaxis.

  34. Effects of low-dose ketamine infusion on remifentanil-induced acute opioid tolerance and the inflammatory response in patients undergoing orthognathic surgery. International-journal Peer-reviewed

    Kanta Kido, Shinichi Toda, Yuki Shindo, Hitoshi Miyashita, Shigekazu Sugino, Eiji Masaki

    Journal of pain research　12　377-385　2019

    DOI： 10.2147/JPR.S177098 　

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    Purpose: Remifentanil is associated with acute opioid tolerance that can lead to increased postoperative consumption of opioid analgesics. The purpose of this study was to determine whether a low dose of ketamine prevents remifentanil-induced acute opioid tolerance and affects the neutrophil-lymphocyte ratio (NLR), a newly recognized biomarker of inflammation. Materials and methods: Forty patients undergoing orthognathic surgery were enrolled in this prospective, randomized, double-blind study and randomly assigned to intraoperative administration of one of the following anesthetic regimens: high-dose remifentanil (0.6 µg/kg/minute); low-dose remifentanil (0.2 µg/kg/minute); or high-dose remifentanil with ketamine (remifentanil 0.6 µg/kg/minute with 0.5 mg/kg ketamine just after induction followed by an intraoperative infusion of ketamine 5 µg/kg/minute until wound closure). Fentanyl by intravenous patient-controlled analgesia was used for postoperative pain control. Visual Analog Scale pain scores and fentanyl consumption were recorded in the first 24 hours postoperatively. Perioperative serum C-reactive protein level and NLR were also determined. Results: Baseline characteristics were similar in the three study groups. There were no between-group differences in Visual Analog Scale pain scores during the study period. The high-dose remifentanil group had a significantly higher requirement for fentanyl than the other two groups. Addition of ketamine did not affect the C-reactive protein level but increased the NLR; this increase was associated with decreased fentanyl consumption. Conclusion: High-dose intraoperative remifentanil induced postoperative acute opioid tolerance that was prevented by infusion of low-dose ketamine. Ketamine increased the postoperative NLR associated with decreased fentanyl requirement for postoperative pain control.

  35. Population-Specific Associations of Deleterious Rare Variants in Coding Region of P2RY1-P2RY12 Purinergic Receptor Genes in Large-Vessel Ischemic Stroke Patients. International-journal Peer-reviewed

    Piotr K Janicki, Ceren Eyileten, Victor Ruiz-Velasco, Khaled Anwar Sedeek, Justyna Pordzik, Anna Czlonkowska, Iwona Kurkowska-Jastrzebska, Shigekazu Sugino, Yuka Imamura-Kawasawa, Dagmara Mirowska-Guzel, Marek Postula

    International journal of molecular sciences　18　(12)　2017/12/11

    DOI： 10.3390/ijms18122678 　

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    The contribution of low-frequency and damaging genetic variants associated with platelet function to ischemic stroke (IS) susceptibility remains unknown. We employed a deep re-sequencing approach in Polish patients in order to investigate the contribution of rare variants (minor allele frequency, MAF < 1%) to the IS genetic susceptibility in this population. The genes selected for re-sequencing consisted of 26 genes coding for proteins associated with the surface membrane of platelets. Targeted pooled re-sequencing (Illumina HiSeq 2500) was performed on genomic DNA of 500 cases (patients with history of clinically proven diagnosis of large-vessel IS) and 500 controls. After quality control and prioritization based on allele frequency and damaging probability, follow-up individual genotyping of deleterious rare variants was performed in patients from the original cohort. Gene-based analyses identified an association between IS and 6 rare functional and damaging variants in the purinergic genes (P2RY1 and P2RY12 locus). The predicted properties of the most damaging rare variants in P2RY1 and P2RY12 were confirmed by using mouse fibroblast cell cultures transfected with plasmid constructs containing cDNA of mutated variants (FLIPR on FlexStation3). This study identified a putative role for rare variants in P2RY1 and P2RY12 genes involved in platelet reactivity on large-vessel IS susceptibility in a Polish population.

  36. Association of frequent genetic variants in platelet activation pathway genes with large-vessel ischemic stroke in Polish population. International-journal Peer-reviewed

    Marek Postula, Piotr K Janicki, Lukasz Milanowski, Justyna Pordzik, Ceren Eyileten, Michal Karlinski, Pawel Wylezol, Marta Solarska, Anna Czlonkowka, Iwona Kurkowska-Jastrzebka, Shigekazu Sugino, Yuka Imamura, Dagmara Mirowska-Guzel

    Platelets　28　(1)　66-73　2017/01

    DOI： 10.1080/09537104.2016.1203404 　

    ISSN： 0953-7104

    eISSN： 1369-1635

  37. Targeted deep resequencing of ALOX5 and ALOX5AP in patients with diabetes and association of rare variants with leukotriene pathways. International-journal Peer-reviewed

    Marek Postula, Piotr Kazimierz Janicki, Marek Rosiak, Ceren Eyileten, Małgorzata Zaremba, Agnieszka Kaplon-Cieslicka, Shigekazu Sugino, Dariusz Artur Kosior, Grzegorz Opolski, Krzysztof Jerzy Filipiak, Dagmara Mirowska-Guzel

    Experimental and therapeutic medicine　12　(1)　415-421　2016/07

    DOI： 10.3892/etm.2016.3334 　

    ISSN： 1792-0981

    eISSN： 1792-1015

  38. Next-generation re-sequencing of genes involved in increased platelet reactivity in diabetic patients on acetylsalicylic acid. International-journal Peer-reviewed

    Marek Postula, Piotr K Janicki, Ceren Eyileten, Marek Rosiak, Agnieszka Kaplon-Cieslicka, Shigekazu Sugino, Radosław Wilimski, Dariusz A Kosior, Grzegorz Opolski, Krzysztof J Filipiak, Dagmara Mirowska-Guzel

    Platelets　27　(4)　357-64　2016/06

    DOI： 10.3109/09537104.2015.1109071 　

    ISSN： 0953-7104

    eISSN： 1369-1635

  39. Association between the low-dose irinotecan regimen-induced occurrence of grade 4 neutropenia and genetic variants of UGT1A1 in patients with gynecological cancers. International-journal Peer-reviewed

    Hiroyuki Moriya, Katsuhiko Saito, Nuala Helsby, Shigekazu Sugino, Michiaki Yamakage, Takeru Sawaguchi, Masahiko Takasaki, Hidenori Kato, Nahoko Kurosawa

    Oncology letters　7　(6)　2035-2040　2014/06

    DOI： 10.3892/ol.2014.2046 　

    ISSN： 1792-1074

    eISSN： 1792-1082

  40. Improvement of Generic Sevoflurane by a New Production Process Peer-reviewed

    Tomo Hayase, Shigekazu Sugino, Shun-suke Tachibana, Naoyuki Hirata, Michiaki Yamakage

    LETTERS IN DRUG DESIGN & DISCOVERY　11　(4)　495-501　2014/05

    DOI： 10.2174/1570180810666131113211447 　

    ISSN： 1570-1808

    eISSN： 1875-628X

  41. Single-nucleotide polymorphisms and copy number variations of the FCGR2A and FCGR3A genes in healthy Japanese subjects. International-journal Peer-reviewed

    Hiroyuki Moriya, Katsuhiko Saito, Nuala Helsby, Naomi Hayashi, Shigekazu Sugino, Michiaki Yamakage, Takeru Sawaguchi, Masahiko Takasaki, Masato Takahashi, Nahoko Kurosawa

    Biomedical reports　2　(2)　265-269　2014/03

    DOI： 10.3892/br.2013.210 　

    ISSN： 2049-9434

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    FcγRII and FcγRIII are low-affinity Fcγ receptors that are encoded by the FCGR2A and FCGR3A genes, respectively. These genes contain functional single-nucleotide polymorphisms (SNPs), which alter the binding affinities of these receptors for the γ chain of the Fc fragment of immunoglobulin G. The known SNPs in FCGR2A and FCGR3A are rs1801274 (A>G; H131R) and rs396991 (T>G; F158V), respectively. It is also known that there are copy number variations (CNVs) in the genetic locus (1q23) where FCGR2A and FCGR3A are located. However, the frequencies of these SNPs and CNVs have not been determined in the Japanese population. The aim of this study was to investigate SNPs and CNVs in FCGR2A and FCGR3A among 113 healthy individuals. The SNPs and CNVs in FCGR2A and FCGR3A were determined using the TaqMan® SNP Genotyping and the TaqMan® Copy Number assays. Our results revealed that the incidence of FCGR2A (rs1801274) genotypes were as follows: A/A, 69.9%; A/G, 29.2%; and G/G, 0.9%. The incidence of the FCGR3A (rs396991) genotypes were as follows: T/T, 56.7%; T/G, 38.9%; and G/G, 4.4%). No CNVs were detected for FCGR2A. To the best of our knowledge, this finding has not been previously reported in the Japanese population. By contrast, CNVs were observed in FCGR3A (3 subjects were found to harbour a gene deletion and 5 subjects had 3 copies of the gene). Using simple commercially available assays we were able to confirm previous findings regarding FCGR2A and FCGR3A alleles and CNVs. These assays may provide a basis for the investigation of the role of these genes in the efficacy of antibody-based drugs, such as trastuzumab and rituximab, in Japanese subjects.

  42. Genomic testing without invasive tumor biopsy. International-journal Peer-reviewed

    Shigekazu Sugino, Piotr Janicki

    Pharmacogenomics　14　(16)　1950-1　2013/12

    eISSN： 1744-8042

  43. Genetic and epigenetic map of acute myeloid leukemia. International-journal Peer-reviewed

    Shigekazu Sugino, Piotr K Janicki

    Pharmacogenomics　14　(16)　1950-1950　2013/12

    ISSN： 1462-2416

    eISSN： 1744-8042

  44. Tumor heterogeneity and response to chemotherapy. International-journal Peer-reviewed

    Shigekazu Sugino, Piotr K Janicki

    Pharmacogenomics　14　(16)　1949-1949　2013/12

    DOI： 10.2217/pgs.13.175 　

    ISSN： 1462-2416

    eISSN： 1744-8042

  45. [Anesthetic management of organ donation after brain death using continuous total hemoglobin measurement]. Peer-reviewed

    Miyuki Tanabe, Shigekazu Sugino, Ryo Miyashita, Tomohiko Kimijima, Eichi Narimatsu, Michiaki Yamakage

    Masui. The Japanese journal of anesthesiology　62　(6)　699-701　2013/06

    ISSN： 0021-4892

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    A 60-year-old woman declared brain dead was scheduled for organ donation. We continuously measured total hemoglobin values (SpHb) using a Radical-7 monitor (Masimo Co, Irvine, CA, USA) to maintain the functions of organs and oxygen delivery. At the start of surgery, the SpHb value was 9.3 g x dl(-1). Packed red blood cells were transfused immediately No anesthetics or opioids were used during the operation. Blood pressure suddenly decreased to below 80 mmHg because of bleeding, manipulation of organs, and/or compression of the vena cava. Six units of red blood cells and 900 ml of colloids were rapidly transfused with real-time monitoring of SpHb values. On cross-clamping of the aorta, the SpHb value increased up to 10.2 g x dl(-1). The heart, lungs, liver, pancreas, and kidneys were donated from the patient without organ dysfunction. The highlight of this case report is that anesthesiologists could use SpHb monitoring for management of hemodynamics in a brain-dead organ donor.

  46. The association between heterozygosity for UGT1A1*6, UGT1A1*28, and variation in the serum total-bilirubin level in healthy young Japanese adults. International-journal Peer-reviewed

    Hiroyuki Moriya, Katsuhiko Saito, Nuala Helsby, Shigekazu Sugino, Michiaki Yamakage, Masahiko Takasaki, Hidenori Kato, Nahoko Kurosawa

    Genetic testing and molecular biomarkers　17　(6)　464-9　2013/06

    DOI： 10.1089/gtmb.2012.0402 　

    ISSN： 1945-0265 1945-0257

  47. [Introduction of translational research in omics science to clinical anesthesia]. Peer-reviewed

    Shigekazu Sugino, Tomo Hayase, Michiaki Yamakage

    Masui. The Japanese journal of anesthesiology　62　(3)　296-303　2013/03

    ISSN： 0021-4892

  48. Utility of longitudinal paramedian view of ultrasound imaging for middle thoracic epidural anesthesia in children. Peer-reviewed

    Nobuko Tachibana, Masanori Yamauchi, Shigekazu Sugino, Akihiko Watanabe, Michiaki Yamakage

    Journal of anesthesia　26　(2)　242-5　2012/04

    DOI： 10.1007/s00540-011-1279-0 　

    ISSN： 0913-8668

  49. Ultrasound-aided ipsilateral-dominant epidural block for total hip arthroplasty: a randomised controlled single-blind study. International-journal Peer-reviewed

    Ryo-ichi Kawaguchi, Masanori Yamauchi, Shigekazu Sugino, Michiaki Yamakage

    European journal of anaesthesiology　28　(2)　137-40　2011/02

    DOI： 10.1097/EJA.0b013e3283423457 　

    ISSN： 0265-0215

  50. [A case of coronary stent thrombosis occurring repeatedly in the perioperative period]. Peer-reviewed

    Misako Higuchi, Shigekazu Sugino, Hayato Echizenya, Yoshitoki Takagawa, Yukihiro Kumeta, Akiyoshi Namiki

    Masui. The Japanese journal of anesthesiology　59　(10)　1311-4　2010/10

    ISSN： 0021-4892

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    A 60-year-old man with angina was scheduled for total gastrectomy, splenectomy, and cholecystectomy. Bare-metal stents were implanted into his left anterior descending coronary artery four weeks before the operation. Aspirin and clopidogrel were administered until one week before the operation and then injection of to 15,000 units of heparin per day was given. Anesthesia was maintained with sevoflurane, remifentanil and fentanyl. At 330 minutes after starting the operation, 2-mm ST segment elevation was observed and it recovered immediately. After the operation, new 9-mm ST segment elevation in leads V2-V6 was observed. Emergent cardiac catheterization showed occlusion of the coronary artery with in-stent thrombosis. An additional stent was implanted and 10,000 units of heparin per day was injected. After five days, new stent thrombosis occurred and an additional stent was implanted. Administration of aspirin, clopidogrel and cilostazol was started immediately. Anesthesiologists should pay attention to the kind of coronary stent, consider the timing of the operation, and continue administration of aspirin.

  51. A new reusable skin-protective sphygmomanometer cuff. International-journal Peer-reviewed

    Eri Gi, Hiroaki Watanabe, Shigekazu Sugino, Tada-Aki Kawae, Akiyoshi Namiki

    Journal of clinical monitoring and computing　24　(3)　209-12　2010/06

    DOI： 10.1007/s10877-010-9233-5 　

    ISSN： 1387-1307

    eISSN： 1573-2614

  52. Ultrasound-aided unilateral epidural block for single lower-extremity pain. Peer-reviewed

    Masanori Yamauchi, Ryoichi Kawaguchi, Shigekazu Sugino, Michiaki Yamakage, Eiji Honma, Akiyoshi Namiki

    Journal of anesthesia　23　(4)　605-8　2009

    DOI： 10.1007/s00540-009-0813-9 　

    ISSN： 0913-8668

  53. [Two cases of epidural anesthesia using ultrasound imaging]. Peer-reviewed

    Ryoichi Kawaguchi, Masanori Yamauch, Shigekazu Sugino, Nobuko Tsukigase, Keiichi Omote, Akiyoshi Namiki

    Masui. The Japanese journal of anesthesiology　56　(6)　702-5　2007/06

    ISSN： 0021-4892

  54. [Anesthetic management of endovascular repair for aortic abdominal aneurysm in a patient with severe chronic obstructive pulmonary disease]. Peer-reviewed

    Shigekazu Sugino, Keiichi Omote, Mikito Kawamata, Akiyoshi Namiki

    Masui. The Japanese journal of anesthesiology　55　(12)　1480-3　2006/12

    ISSN： 0021-4892

  55. Effects of systemic administration of lidocaine and QX-314 on hyperexcitability of spinal dorsal horn neurons after incision in the rat. International-journal Peer-reviewed

    Mikito Kawamata, Shigekazu Sugino, Eichi Narimatsu, Masanori Yamauchi, Tomohiro Kiya, Shingo Furuse, Akiyoshi Namiki

    Pain　122　(1-2)　68-80　2006/05

    DOI： 10.1016/j.pain.2006.01.004 　

    ISSN： 0304-3959

    eISSN： 1872-6623

  56. [Anesthetic management in a patient with Goldenhar's syndrome using a perilaryngeal airway and a videolaryngoscope]. Peer-reviewed

    Shigekazu Sugino, Noriaki Kanaya, Keiichi Omote, Akiyoshi Namiki

    Masui. The Japanese journal of anesthesiology　54　(12)　1367-70　2005/12

    ISSN： 0021-4892

  57. [Evaluation of autologous transfusion for radical prostatectomy]. Peer-reviewed

    Shigekazu Sugino, Yasuo Shichinohe, Hiromitsu Kuroda, Shigeo Tsuchiya, Kazumasa Tsunoda, Junri Shindoh, Nobuyasu Enami, Akiyoshi Namiki

    Masui. The Japanese journal of anesthesiology　54　(7)　762-6　2005/07

    ISSN： 0021-4892

  58. Effects of halothane and isoflurane on hyperexcitability of spinal dorsal horn neurons after incision in the rat. International-journal Peer-reviewed

    Mikito Kawamata, Eichi Narimatsu, Yuji Kozuka, Toshiyuki Takahashi, Shigekazu Sugino, Tomohisa Niiya, Akiyoshi Namiki

    Anesthesiology　102　(1)　165-74　2005/01

    DOI： 10.1097/00000542-200501000-00025 　

    ISSN： 0003-3022

  59. [Anesthetic management for a patient with Charcot-Marie-Tooth disease using propofol and nitrous oxide]. Peer-reviewed

    Shigekazu Sugino, Yutaka Yamazaki, Yuko Nawa, Kouichi Sato, Hajime Sonoda, Akiyoshi Namiki

    Masui. The Japanese journal of anesthesiology　51　(9)　1016-9　2002/09

    ISSN： 0021-4892

  60. A case of acute exacerbation of idiopathic interstitial pneumonia after pneumonectomy Peer-reviewed

    S. Sugino, N. Kanaya, A. Namiki

    Japanese Journal of Anesthesiology　49　(2)　187-190　2000

    ISSN： 0021-4892

  61. Caesarian section using a temporary IVC filter in a pregnant woman with several histories of deep vein thrombosis Peer-reviewed

    S. Sugino, H. Imaizumi, Y. Shichinohe, M. Aimono, A. Namiki

    Japanese Journal of Anesthesiology　49　(3)　295-297　2000

    ISSN： 0021-4892

Show all ︎Show first 5

Misc. 113

  1. 人工知能による脊椎麻酔術後の悪心嘔吐のリスク因子の予測:観察研究 Peer-reviewed

    星島宏, 宮崎智, 紺野大輔, 杉野繁一, 水田健太郎, 山内正憲

    日本麻酔科学会第71回学術集会　2024/06

  2. 術後疼痛管理チームの介入を4日以上必要とした症例の分析 Peer-reviewed

    合谷木諒, 杉野繁一, 矢吹志津葉, 本間舞子, 小野理恵, 山内正憲

    日本麻酔科学会第71回学術集会　2024/06

  3. 末梢神経ブロックに併用した高周波パルスの通電はFynチロシンキナーゼ発現を介して術後痛を減弱する Peer-reviewed

    杉野繁一, 山内正憲

    日本区域麻酔学会第11回学術集会　2024/04

  4. 低侵襲心臓手術における前鋸筋面ブロックプログラム間欠投与の術後鎮痛効果：ランダム化比較試験 Peer-reviewed

    佐藤友菜, 熊谷道雄, 海法悠, 関根智宏, 杉野繁一, 井上洋, 伊藤淳, 山内正憲

    第51回日本集中治療医学会学術集会　2024/03

  5. droperidolを併用したfentanylによる経静脈的患者自己調節鎮痛法の検討：単施設観察研究 Peer-reviewed

    鈴木潤, 本間舞子, 矢吹 志津葉, 小野理恵, 高野淳, 杉野繁一, 山内正憲

    第51回日本集中治療医学会学術集会　2024/03

  6. 高周波パルス療法の術後痛への応用：ラット術後痛モデルの疼痛関連行動解析 Peer-reviewed

    徳永莉子, 鈴木潤, 小玉哲也, 山内正憲

    日本ペインクリニック学会第4回東北支部学術集会　2023/12

  7. 眼咽頭筋型筋ジストロフィー患者におけるロボット支援腹腔鏡下手術の麻酔経験 Peer-reviewed

    泉山仁志, 鈴木潤, 船橋優太郎, 金谷明浩, 杉野繁一, 山内正憲

    日本臨床麻酔学会第43回大会　2023/11

  8. 手術室看護師による術後疼痛管理チームの立ち上げ Peer-reviewed

    滝沢香菜, 杉野繁一, 本間舞子, 鈴木潤, 高野淳, 竹森加菜子, 山内正憲

    日本臨床麻酔学会第43回大会　2023/11

  9. 呼吸器外科から始める術後疼痛管理チームのすすめ Peer-reviewed

    本間舞子, 杉野繁一, 鈴木潤, 高野淳, 山内正憲

    日本臨床麻酔学会第43回大会　2023/11

  10. 術後疼痛管理チームにおける薬剤師の貢献 Peer-reviewed

    鈴木寿樹, 田中里奈, 森下啓, 本間舞子, 杉野繁一, 滝沢香菜, 高野淳, 矢吹志津葉, 鈴木潤, 松浦正樹, 眞野成康

    第33回日本医療薬学会年会　2023/11

  11. 術後疼痛管理チーム活動における診療看護師(NP)のタスクシェアリング Peer-reviewed

    高野淳, 杉野繁一, 本間舞子, 鈴木潤, 矢吹志津葉, 山内正憲

    第9回日本NP学会　2023/10

  12. 講座 高齢患者の術後を見据えて麻酔法を選択する Invited Peer-reviewed

    間島卓哉, 杉野繁一

    臨床麻酔　47　(9)　1041-1049　2023/09

  13. APS介入で減少したフェンタニルivPCAによる悪心嘔吐 Peer-reviewed

    本間舞子, 鈴木潤, 矢吹志津葉, 大西詠子, 齋藤秀悠, 山内正憲

    日本ペインクリ ニック学会第57回学術集会　2023/07

  14. COVID-19凝固障害患者におけるextracelluler vesicles産生量の比較;前向き観察研究 Peer-reviewed

    岩崎夢大, 武井祐介, 杉野繁一, 山内正憲

    日本麻酔科学会第70回学術集会　2023/06

  15. 細胞外小胞に着目した人工呼吸関連肺傷害の内皮傷害マーカーの探索 Peer-reviewed

    武井 祐介, 岩崎 夢大, 紺野 大輔, 入間田 大介, 関根 智宏, 齋藤 秀悠, 杉野 繁一, 鈴木 潤, 山内 正憲

    日本集中治療医学会雑誌　30　(Suppl.1)　S579-S579　2023/06

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

    eISSN： 1882-966X

  16. 臨床に即した遷延性術後痛モデル動物の開発とtranscriptome profiling Peer-reviewed

    鈴木 潤, 杉野 繁一, 齋藤 秀悠, 本間 舞子, 山内 正憲

    日本ペインクリニック学会誌　30　(5)　120-121　2023/05

    Publisher: (一社)日本ペインクリニック学会

    ISSN： 1340-4903

    eISSN： 1884-1791

  17. 嘔吐する実験動物スンクスを用いてPONVの機序をゲノムレベルで探索する Invited Peer-reviewed

    杉野繁一

    Anet　27　(2)　10-13　2023/04

  18. 集中治療室における術後せん妄発症の危険因子 Peer-reviewed

    周 穎哲, 鎌田 ことえ, 杉野 繁一, 萩平 哲, 山内 正憲

    日本老年麻酔学会プログラム・抄録集　35回　35-35　2023/03

    Publisher: 日本老年麻酔学会

  19. 剪断波速度を用いた筋緊張の定量化 麻酔導入時における前向き観察研究 Peer-reviewed

    高桑 こころ, 杉野 繁一, 齋藤 秀悠, 金谷 明浩, 茂木 章一郎, 山内 正憲

    日本臨床麻酔学会誌　42　(6)　S181-S181　2022/10

    Publisher: 日本臨床麻酔学会

    ISSN： 0285-4945

    eISSN： 1349-9149

  20. 【痛みの精密医療の展開に向けて】全身麻酔後の悪心嘔吐と精密医療 Invited Peer-reviewed

    杉野 繁一

    Precision Medicine　5　(2)　123-126　2022/02

    Publisher: (株)北隆館

    ISSN： 2434-3625

  21. 重複大動脈弓を合併した高齢者の胸腔鏡下食道癌手術の1症例 Peer-reviewed

    重田 惟, 杉野 繁一, 鎌田 ことえ, 山内 正憲

    日本老年麻酔学会プログラム・抄録集　34回　23-23　2022/02

    Publisher: 日本老年麻酔学会

  22. 【麻酔】術後悪心・嘔吐(PONV) 最新の指針にもとづく発症予測・予防・治療 Invited Peer-reviewed

    関根 智宏, 杉野 繁一

    Intensivist　13　(4)　755-763　2021/10

    Publisher: (株)メディカル・サイエンス・インターナショナル

    ISSN： 1883-4833

    eISSN： 2186-7852

  23. EQUATORネットワークの各種指針を使って素敵な研究プロトコールを作ろう Invited Peer-reviewed

    杉野 繁一

    日本小児麻酔学会大会プログラム　26回　75-75　2021/10

    Publisher: (一社)日本小児麻酔学会

  24. 絞扼性イレウスの重症度と術前プロカルシトニン値の関係 Peer-reviewed

    角田 博, 武井 祐介, 杉野 繁一, 山内 正憲

    Shock: 日本Shock学会雑誌　35　(1)　53-53　2021/05

    Publisher: (一社)日本Shock学会

    ISSN： 0919-8156

    eISSN： 2185-8225

  25. 凍結肩の診療の現況と治療指針の提言 Invited Peer-reviewed

    山内 正憲, 臼井 要介, 杉野 繁一, 山本 宣幸

    日本ペインクリニック学会誌　28　(5)　72-72　2021/05

    Publisher: (一社)日本ペインクリニック学会

    ISSN： 1340-4903

    eISSN： 1884-1791

  26. 非侵害性刺激後の脳内c-fos発現に対するオキシトシン神経系の関与 Peer-reviewed

    齋藤 秀悠, 日出間 志寿, 西森 克彦, 齊藤 和智, 熊谷 道雄, 村上 徹, 杉野 繁一, 山内 正憲

    日本ペインクリニック学会誌　28　(5)　76-77　2021/05

    Publisher: (一社)日本ペインクリニック学会

    ISSN： 1340-4903

    eISSN： 1884-1791

  27. 超音波エラストグラフィを用いた筋肉の弾性評価 Peer-reviewed

    齋藤 秀悠, 杉野 繁一, 江島 豊, 山内 正憲

    医療機器学　91　(2)　230-230　2021/04

    Publisher: (一社)日本医療機器学会

    ISSN： 1882-4978

    eISSN： 1884-054X

  28. 高齢者における全身麻酔後の重症度の高いシバリング発症例の後方視的検討 Peer-reviewed

    武田 明己, 角田 博, 杉野 繁一, 山内 正憲

    日本老年麻酔学会プログラム・抄録集　33回　45-45　2021/02

    Publisher: 日本老年麻酔学会

  29. 凍結肩診療の現況調査 Peer-reviewed

    齋藤 可奈, 鎌田 ことえ, 杉野 繁一, 廣瀬 聰明, 山内 正憲

    日本老年麻酔学会プログラム・抄録集　33回　60-60　2021/02

    Publisher: 日本老年麻酔学会

  30. 凍結肩の治療における神経ブロックと理学療法の有用性 ネットワークメタ解析におけるサブグループ解析 Peer-reviewed

    茂木 章一郎, 杉野 繁一, 鎌田 ことえ, 山内 正憲

    日本老年麻酔学会プログラム・抄録集　33回　61-61　2021/02

    Publisher: 日本老年麻酔学会

  31. オキシトシンのマウス上位中枢における各種刺激に対する作用 Peer-reviewed

    齋藤秀悠, 齊藤和智, 村上徹, 杉野繁一, 外山裕章, 山内正憲

    日本麻酔科学会学術集会(Web)　68th　2021

  32. 3Dプリンティングで大血管と下気道を立体造形して腹臥位で分離肺換気を行った重複大動脈弓の1症例 Peer-reviewed

    重田惟, 杉野繁一, 濱田健志, 小野理恵, 小野理恵, 外山裕章, 山内正憲

    日本麻酔・集中治療テクノロジー学会プログラム・抄録集(Web)　39th　2021

  33. 高齢者・超高齢者における周術期麻酔管理の特徴と問題点 高齢者の遷延性術後痛 Invited Peer-reviewed

    杉野 繁一, 鈴木 潤

    日本臨床麻酔学会誌　40　(6)　S173-S173　2020/10

    Publisher: 日本臨床麻酔学会

    ISSN： 0285-4945

    eISSN： 1349-9149

  34. 腹部大動脈瘤破裂手術の輸血量に関与する因子の検討 Peer-reviewed

    鈴木 潤, 岡田 吉史, 佐藤 怜子, 大森 千恵子, 武中 敏恵, 入間田 悌二, 杉野 繁一, 山内 正憲

    麻酔　69　(4)　368-373　2020/04

    Publisher: 克誠堂出版(株)

    ISSN： 0021-4892

  35. 高齢の乳がん手術患者における遷延性術後痛と術中のオピオイド投与との関与 Peer-reviewed

    重田 惟, 鈴木 潤, 杉野 繁一, 吾妻 俊弘, 山内 正憲

    日本老年麻酔学会プログラム・抄録集　32回　67-67　2020/01

    Publisher: 日本老年麻酔学会

  36. endothelial microparticlesに着目した急性呼吸促迫症候群における肺血管内皮傷害の検討

    武井 祐介, 齋藤 浩二, 亀山 良亘, 齊藤 和智, 金谷 明浩, 杉野 繁一, 吾妻 俊弘, 江島 豊, 志賀 卓弥, 山内 正憲

    日本集中治療医学会雑誌　25　(Suppl.)　[O69-2]　2018/02

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

  37. endothelial microparticlesに着目した急性呼吸促迫症候群における肺血管内皮傷害の検討 Peer-reviewed

    武井 祐介, 齋藤 浩二, 亀山 良亘, 齊藤 和智, 金谷 明浩, 杉野 繁一, 吾妻 俊弘, 江島 豊, 志賀 卓弥, 山内 正憲

    日本集中治療医学会雑誌　25　(Suppl.)　[O69-2]　2018/02

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

  38. HFNC脱落症例に対しNPPVを選択すればICU滞在を短縮できる可能性がある Peer-reviewed

    紺野 大輔, 杉野 繁一, 齊藤 浩二, 村木 大志, 亀山 良亘, 民井 亨, 村上 徹, 星 邦彦, 山内 正憲

    日本集中治療医学会雑誌　25　(Suppl.)　[O70-3]　2018/02

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

  39. 過去10年間の当院産科ICUの検討 Peer-reviewed

    亀山 良亘, 齋藤 浩二, 志賀 卓弥, 杉野 繁一, 吾妻 俊弘, 山内 正憲

    日本集中治療医学会雑誌　24　(Suppl.)　DP41-1　2017/02

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

    eISSN： 1882-966X

  40. 人工呼吸管理後に新規のテロメラーゼ遺伝子多型を同定できた家族性肺繊維症の妊婦の1症例 Peer-reviewed

    杉野 繁一, 金谷 明浩, 山内 正憲

    日本集中治療医学会雑誌　23　(Suppl.)　769-769　2016/01

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

    eISSN： 1882-966X

  41. 日本人の婦人科癌患者におけるイリノテカン低用量レジメンによるグレード4の好中球減少の発現とUGT1A1遺伝子変異との関連 Peer-reviewed

    守屋 寛之, 齊藤 嘉津彦, Helsby Nuala, 杉野 繁一, 山蔭 道明, 澤口 武尊, 高崎 雅彦, 加藤 秀則, 黒澤 菜穂子

    日本薬学会年会要旨集　135年会　(4)　202-202　2015/03

    Publisher: (公社)日本薬学会

    ISSN： 0918-9823

  42. 局所麻酔薬の頭皮下投与後の血中濃度 Peer-reviewed

    山下 美妃, 向 祐志, 戸田 貴大, 猪爪 信夫, 郡 修徳, 茶木 友浩, 杉野 繁一, 早瀬 知, 山蔭 道明

    臨床薬理　45　(Suppl.)　S267-S267　2014/11

    Publisher: (一社)日本臨床薬理学会

    ISSN： 0388-1601

    eISSN： 1882-8272

  43. 健常日本人における血清総ビリルビン値のUGT1A1*6と*28ヘテロ接合体および性別による変動 Peer-reviewed

    守屋 寛之, 齊藤 嘉津彦, Helsby Nuala, 杉野 繁一, 山蔭 道明, 高崎 雅彦, 加藤 秀則, 黒澤 菜穂子

    日本薬学会年会要旨集　134年会　(3)　137-137　2014/03

    Publisher: (公社)日本薬学会

    ISSN： 0918-9823

  44. 気道確保にMcGRATHが有用であったBlue rubber bleb nevus syndromeの1症例 Peer-reviewed

    数馬 聡, 杉野 繁一, 早瀬 知, 水口 亜紀, 山蔭 道明

    日本臨床麻酔学会誌　33　(6)　S251-S251　2013/10

    Publisher: 日本臨床麻酔学会

    ISSN： 0285-4945

    eISSN： 1349-9149

  45. 非侵襲的全ヘモグロビン濃度測定が有効であった脳死下臓器提供の1症例 Peer-reviewed

    田辺 美幸, 杉野 繁一, 宮下 龍, 君島 知彦, 成松 英智, 山蔭 道明

    麻酔　62　(6)　699-701　2013/06

    Publisher: 克誠堂出版(株)

    ISSN： 0021-4892

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    60歳代女。自宅で意識消失し、高度救命救急センターに搬入された。頭部CTで、くも膜下出血とびまん性脳浮腫を認めた。第2病日には、脳幹反射の消失、平坦脳波、さらに尿崩症の出現を認め、臨床的に脳死と判断した。臓器提供意思表示カードの所持はなかったが、家族に臓器提供の意思があったため、2回の法的脳死判定後、第4病日に脳死下臓器摘出術を予定した。麻酔導入時の動脈血液ガス分析装置を用いたヘモグロビン値は、目標値である10g/dlを下回っていたため、ただちに赤血球濃厚液の投与を開始した。大動脈遮断後はすべての輸液・薬物の投与と人工呼吸を中止し、中心静脈カテーテルを抜去した後、心臓、肺、肝臓、膵臓、ならびに腎臓を摘出し、気管チューブを抜去した。

  46. 【麻酔科学領域の基礎研究の臨床応用】 麻酔科学へのオミクス研究の導入と臨床麻酔での可能性 Invited Peer-reviewed

    杉野 繁一, 早瀬 知, 山蔭 道明

    麻酔　62　(3)　296-303　2013/03

    Publisher: 克誠堂出版(株)

    ISSN： 0021-4892

  47. 麻酔科学 全身麻酔と脳内アセチルコリン受容体 Invited Peer-reviewed

    杉野 繁一

    医学のあゆみ　240　(12)　985-985　2012/03

    Publisher: 医歯薬出版(株)

    ISSN： 0039-2359

  48. 病棟帰室後にICUへ緊急入室となった術後症例の検討 Peer-reviewed

    赤塚 正幸, 吉田 真一郎, 今泉 均, 升田 好樹, 後藤 京子, 喜屋武 玲子, 君島 知彦, 巽 博臣, 杉野 繁一, 山蔭 道明

    日本集中治療医学会雑誌　19　(Suppl.)　216-216　2012/01

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

    eISSN： 1882-966X

  49. 聴性誘発電位モニタリングを用いた意識下開頭手術の麻酔管理 Peer-reviewed

    石岡 慶己, 杉野 繁一, 早瀬 知, 高橋 和伸, 古瀬 晋吾, 山蔭 道明

    日本臨床麻酔学会誌　31　(6)　S328-S328　2011/10

    Publisher: 日本臨床麻酔学会

    ISSN： 0285-4945

    eISSN： 1349-9149

  50. 持続SpHb測定が有用であった脳死下臓器提供の1症例 Peer-reviewed

    田辺 美幸, 杉野 繁一, 君島 知彦, 宮下 龍, 山蔭 道明

    日本臨床麻酔学会誌　31　(6)　S428-S428　2011/10

    Publisher: 日本臨床麻酔学会

    ISSN： 0285-4945

    eISSN： 1349-9149

  51. 聴性誘発電位モニタaepEXの測定値はBISと非線形に相関する Peer-reviewed

    早瀬 知, 杉野 繁一, 石岡 慶己, 山蔭 道明

    臨床モニター　22　(Suppl.)　44-44　2011/04

    Publisher: 医学図書出版(株)

    ISSN： 0915-6976

  52. 周術期に頻回に発症した冠動脈ステント血栓症の1症例 Peer-reviewed

    樋口 美沙子, 杉野 繁一, 越前谷 勇人, 高川 芳勅, 久米田 幸弘, 並木 昭義

    麻酔　59　(10)　1311-1314　2010/10

    Publisher: 克誠堂出版(株)

    ISSN： 0021-4892

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    60歳男。吐血で救急搬送され、緊急開腹止血術を行った。病理検査により出血の原因は胃癌と診断され、胃全摘術が予定された。術前の運動負荷心電図でST変化を認め、冠動脈造影を行ったところ3枝変化を認めたため、左前下行枝に2本のbare-metal stent(BMS)を留置した。留置後3週間はアスピリンとクロピドグレルを服用し、その後手術開始直前まで未分化ヘパリンを持続静注した。第92病日に全身麻酔下で胃・脾・胆嚢摘出術を行い、手術開始5時間半経過ごろに心電図でST変化を数回認めた。約6時間で手術終了し、術後1時間に行った12誘導心電図ではV2-6で最大9mmのST上昇を認め、ステント血栓症を疑って緊急冠動脈造影を行った。BMSの末梢から先が血栓で閉塞しており、血栓を吸引しBMSを留置した。しかし、5分後の再造影で血栓を認め、BMSを再留置した。術後ヘパリンを使用したが、第97病日に再び血栓症を生じ、BMS再留置となった。同日よりアスピリン、クロピドグレル、シロスタゾールを開始し、その後血栓症はなく、第149病日に退院した。

  53. 超低体温循環停止を用いた胸部下行大動脈瘤手術では運動誘発電位の変化は脊髄虚血を反映しない Peer-reviewed

    君島 知彦, 宮下 龍, 杉野 繁一, 山蔭 道明

    Cardiovascular Anesthesia　14　(Suppl.)　169-169　2010/10

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN： 1342-9132

    eISSN： 1884-7439

  54. 中規模市中病院におけるオートプシー・イメージングの現況報告 Peer-reviewed

    南部 敏和, 阿部 俊男, 杉野 繁一, 樋口 美沙子, 久米田 幸弘

    Japanese Journal of Radiology　28　(Suppl.I)　6-6　2010/07

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  55. SSRIの過量服薬により重篤なセロトニン症候群を呈したOCDの1例 Peer-reviewed

    亀山 梨絵, 鈴木 悠史, 笹川 嘉久, 千秋 勉, 高丸 勇司, 樋口 美沙子, 杉野 繁一, 久米田 幸弘

    精神神経学雑誌　112　(1)　77-77　2010/01

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  56. 選択的セロトニン再取り込み阻害薬の中毒患者に発症したセロトニン症候群の1症例 Peer-reviewed

    早瀬 知, 杉野 繁一, 樋口 美沙子, 久米田 幸弘, 並木 昭義

    日本集中治療医学会雑誌　17　(Suppl.)　376-376　2010/01

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

    eISSN： 1882-966X

  57. フェンタニル静脈内自己調節鎮痛法を用いた術後患者におけるμ-オピオイド受容体遺伝子のSNPs解析 Peer-reviewed

    早瀬 知, 杉野 繁一, 樋口 美沙子, 久米田 幸弘, 並木 昭義

    日本臨床麻酔学会誌　29　(6)　S272-S272　2009/09

    Publisher: 日本臨床麻酔学会

    ISSN： 0285-4945

    eISSN： 1349-9149

  58. 胸部MR拡散強調画像による急性心筋梗塞死後診断の試み Peer-reviewed

    樋口 美沙子, 杉野 繁一, 久米田 幸弘, 阿部 俊男, 南部 敏和

    北海道外科雑誌　54　(1)　80-81　2009/06

    Publisher: 北海道外科学会

    ISSN： 0288-7509

  59. 持続血液濾過施行患者におけるテイコプラニンのTDMを行った1症例 Peer-reviewed

    桐越 慶, 伊佐治 麻里子, 直江 可奈子, 四藤 理佳, 尾崎 裕之, 前田 直大, 山形 昌弘, 橋本 哲郎, 入山 美知, 松原 浩司, 下澤 みづえ, 小田 貴実子, 作田 典夫, 新岡 正法, 樋口 美沙子, 杉野 繁一, 久米田 幸弘

    TDM研究　26　(3)　s204-s204　2009/06

    Publisher: (一社)日本TDM学会

    ISSN： 0911-1026

  60. 穿刺が困難であった脊髄くも膜下麻酔における腰椎変形度の定量化 Peer-reviewed

    樋口 美沙子, 杉野 繁一, 久米田 幸弘

    麻酔　58　(3)　391-392　2009/03

    Publisher: 克誠堂出版(株)

    ISSN： 0021-4892

  61. 麻酔科クリニカルクラークシップにおけるバイタルサインの教育 Peer-reviewed

    樋口 美沙子, 杉野 繁一, 平田 直之, 古瀬 晋吾, 山蔭 道明, 久米田 幸弘, 並木 昭義

    麻酔　58　(3)　393-393　2009/03

    Publisher: 克誠堂出版(株)

    ISSN： 0021-4892

  62. 集中治療における診断群分類に基づいた包括評価と患者重症度の関連 Peer-reviewed

    杉野 繁一, 七戸 康夫, 鎌田 康宏, 宮下 龍, 木村 陽, 黒田 浩光, 勝木 良雄, 並木 昭義

    日本集中治療医学会雑誌　16　(1)　39-43　2009/01

    Publisher: (一社)日本集中治療医学会

    DOI： 10.3918/jsicm.16.39 　

    ISSN： 1340-7988

    eISSN： 1882-966X

  63. オートプシー・イメージングにおける胸部MRIを用いた急性冠症候群の検出 Peer-reviewed

    樋口 美沙子, 杉野 繁一, 阿部 俊男, 南部 敏和, 久米田 幸弘

    日本集中治療医学会雑誌　16　(Suppl.)　241-241　2009/01

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

    eISSN： 1882-966X

  64. 院外心肺停止患者におけるオートプシー・イメージングの診断精度

    樋口 美沙子, 杉野 繁一, 南部 敏和, 久米田 幸弘

    日本救急医学会雑誌　19　(8)　750-750　2008/08

    Publisher: (一社)日本救急医学会

    ISSN： 0915-924X

    eISSN： 1883-3772

  65. 経皮的気管切開キットを用いた緊急気道確保 fresh cadaverによる検討 Peer-reviewed

    関 忍, 杉野 繁一, 中山 雅康, 山内 正憲, 佐藤 順一, 山蔭 道明, 並木 昭義, 青木 光広, 鈴木 大輔, 辰巳 治之

    麻酔　57　(7)　908-909　2008/07

    Publisher: 克誠堂出版(株)

    ISSN： 0021-4892

  66. 入室時の発作性心房細動のため手術延期となったが同日、緊急手術となった骨盤内臓全摘術の1症例 Peer-reviewed

    澤田 敦史, 杉野 繁一, 福岡 英子, 山蔭 道明, 金谷 憲明, 並木 昭義

    北海道外科雑誌　53　(1)　127-127　2008/06

    Publisher: 北海道外科学会

    ISSN： 0288-7509

  67. 肺高血圧症を合併したGoldenhar症候群に分離肺換気を施行した1症例 Peer-reviewed

    佐藤 久仁子, 杉野 繁一, 月ヶ瀬 信子, 中山 雅康, 並木 昭義, 中山 禎人

    麻酔　57　(5)　651-651　2008/05

    Publisher: 克誠堂出版(株)

    ISSN： 0021-4892

  68. マニュアルジェットベンチレータと経皮的気管切開キットによる緊急気道確保 Fresh Cadaver Study Peer-reviewed

    本間 広則, 杉野 繁一, 関 忍, 中山 雅康, 升田 好樹, 今泉 均, 青木 光広, 鈴木 大輔, 辰巳 治之, 並木 昭義

    日本集中治療医学会雑誌　15　(Suppl.)　191-191　2008/01

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

    eISSN： 1882-966X

  69. エアウェイスコープによるダブルルーメンチューブの気管挿管 Peer-reviewed

    中山 禎人, 西條 裕正, 杉野 繁一, 金谷 憲明, 並木 昭義

    臨床麻酔　31　(7)　1191-1193　2007/07

    Publisher: 真興交易(株)医書出版部

    ISSN： 0387-3668

  70. 超音波画像を用いて硬膜外麻酔を行った2症例 Peer-reviewed

    川口 亮一, 山内 正憲, 杉野 繁一, 月ヶ瀬 信子, 表 圭一, 並木 昭義

    麻酔　56　(6)　702-705　2007/06

    Publisher: 克誠堂出版(株)

    ISSN： 0021-4892

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    初期臨床研修医が小児症例および肥満症例の硬膜外麻酔を、超音波画像(エコー)を用いることでスムーズに行った症例を経験した。症例1(11歳女児)。右距骨骨軟骨損傷に対し観血的骨接合術を予定した。麻酔は全身麻酔とL5-S1棘間の硬膜外麻酔の併用とした。良好な鎮痛効果を得ることができた。硬膜外穿刺および麻酔管理上の合併症はなかった。症例2(36歳女)。腹式子宮筋腫核出術を予定した。前投薬は施行せずに手術室入室とした。麻酔方法は全身麻酔とT12-L1からの硬膜外麻酔の併用とした。術後はフルルビプロフェンの経静脈投与を一度行ったのみで、副作用や合併症はなかった。

  71. 超音波画像を用いて仙骨硬膜外カテーテルを挿入した1例 Peer-reviewed

    樋口 美沙子, 山内 正憲, 中山 雅康, 杉野 繁一, 山蔭 道明, 並木 昭義

    臨床麻酔　31　(2)　253-254　2007/02

    Publisher: 真興交易(株)医書出版部

    ISSN： 0387-3668

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    2歳4ヵ月男児。出生後からRDS、気管支痙攣、慢性肺疾患、副腎不全のため小児科でフォローされており、今回、尿道下裂に対して尿道形成術を予定した。前投薬としてトリクロホスナトリウムを服用させ、酸素・亜酸化窒素・セボフルランによる緩徐導入とベクロニウム静脈内投与で気管挿管を行った後、右側臥位として仙骨硬膜外穿刺を行った。仙骨裂孔を触診で確認し、抵抗消失法で18GのTuohy針を進め、皮膚から2cmで硬膜外腔に到達した。他の麻酔医が5〜10MHzリニア型超音波プローブを用いてL5/S1の水平断像を描出し、穿刺者が硬膜、黄色靱帯を観察しながら硬膜外カテーテルを挿入した。カテーテルを硬膜外に11cm進めた時、カテーテルの動きに同期したL5/S1の動きを確認し、その部位に留置した。硬膜外腔へは20万倍アドレナリン添加1%リドカインを執刀20分前に8ml、手術開始75分後、140分後に4mlずつ投与した。鎮痛効果は良好で、手術は問題なく終了した。

  72. マウス系統間におけるDAMGOの脳室内投与に対する疼痛行動の変化 Peer-reviewed

    杉野 繁一, 川真田 樹人, 山内 正憲, 木谷 友洋, 並木 昭義

    麻酔　56　(1)　103-103　2007/01

    Publisher: 克誠堂出版(株)

    ISSN： 0021-4892

  73. 脊髄後角膠様質ニューロンの抑制性シナプス伝達に対する麻酔薬の影響 in vivoパッチクランプ法による検討 Peer-reviewed

    木谷 友洋, 川真田 樹人, 小塚 雄史, 杉野 繁一, 山内 正憲, 成松 英智, 並木 昭義

    麻酔　56　(1)　103-104　2007/01

    Publisher: 克誠堂出版(株)

    ISSN： 0021-4892

  74. 最重症のCOPDを合併した腹部大動脈瘤患者に対するステントグラフト内挿術の1症例 Peer-reviewed

    杉野 繁一, 表 圭一, 川真田 樹人, 並木 昭義

    麻酔　55　(12)　1480-1483　2006/12

    Publisher: 克誠堂出版(株)

    ISSN： 0021-4892

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    症例は66歳の男性で、腹部大動脈瘤に対するステントグラフト内挿術が予定されたが、63歳時から肺気腫に対する在宅酸素療法中であった。検査により、呼吸機能は最重症であると判定され、麻酔は脊髄クモ膜下麻酔と浸潤麻酔を選択した。術中には鎮静剤を使用せず、経鼻にて酸素投与を行い、周術期における呼吸状態の悪化は認められなかった。手術時間は3時間30分、麻酔時間は4時間40分であった。

  75. 抗菌薬投与に関連するアナフィラキシー対策のガイドラインに基づき治療しえた手術中のショックの1例 Peer-reviewed

    杉目 史行, 杉野 繁一, 山内 正憲, 岩崎 創史, 中山 雅康, 金谷 憲明, 並木 昭義

    日本化学療法学会雑誌　54　(6)　531-534　2006/11

    Publisher: (公社)日本化学療法学会

    DOI： 10.11250/chemotherapy1995.54.531 　

    ISSN： 1340-7007

    eISSN： 1884-5886

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    63歳女、Bowen病と診断され、肛門部周囲切除と人工肛門造設が予定された。C型肝炎、子宮体癌に対する子宮全摘術の既往があった。全身麻酔導入後、感染予防目的にセフメタゾール(CMZ)を点滴静注した。5分後、急激な血圧低下、顔面・手掌の発赤・浮腫を認め、CMZによるアナフィラキシーショックが疑われた。直ちにCMZを中止し、血圧低下に対して細胞外液、エピネフリンの静脈内投与、ドパミン投与を行った。気道内圧上昇を認めたため、テオフィリンを30分間持続投与した。さらにメチルプレドニゾロン、クロルフェニラミンを静注した。手術は人工肛門の作成に留め終了した。ショック発症70分後には顔面・手掌の発赤・浮腫は消退した。ショック状態が遷延したため、術後気管挿管されたままICU入室となり、離脱に2日を要した。術後3日目に経過良好でICU退室となり、一般病棟に転床した。本症例は「抗菌薬投与に関連するアナフィラキシー対策のガイドライン」に基づき迅速に対応することが可能であった。

  76. 硬膜外穿刺の距離と各種画像上計測値の相関 Peer-reviewed

    山内 正憲, 川口 亮一, 杉野 繁一, 並木 昭義

    日本臨床麻酔学会誌　26　(6)　S201-S201　2006/10

    Publisher: 日本臨床麻酔学会

    ISSN： 0285-4945

    eISSN： 1349-9149

  77. 超音波画像を用いて仙骨硬膜外カテーテル挿入を施行した1例 Peer-reviewed

    樋口 美沙子, 山内 正憲, 中山 雅康, 杉野 繁一, 山蔭 道明, 並木 昭義

    日本臨床麻酔学会誌　26　(6)　S291-S291　2006/10

    Publisher: 日本臨床麻酔学会

    ISSN： 0285-4945

    eISSN： 1349-9149

  78. デクスメデトミジンを用いて気道管理した気管ステント挿入術の1症例 Peer-reviewed

    河村 真衣子, 杉野 繁一, 岩崎 創史, 山蔭 道明, 渡辺 廣昭, 並木 昭義

    日本臨床麻酔学会誌　26　(6)　S302-S302　2006/10

    Publisher: 日本臨床麻酔学会

    ISSN： 0285-4945

    eISSN： 1349-9149

  79. 電子麻酔記録を用いた麻酔診療評価の試み Peer-reviewed

    川口 亮一, 杉野 繁一, 山内 正憲, 山蔭 道明, 渡辺 廣昭, 明和 裕司, 並木 昭義

    日本臨床麻酔学会誌　26　(6)　S413-S413　2006/10

    Publisher: 日本臨床麻酔学会

    ISSN： 0285-4945

    eISSN： 1349-9149

  80. 幼若ラットの膠様質ニューロンの機能特性 in vivoパッチクランプ法による解析 Peer-reviewed

    川真田 樹人, 杉野 繁一, 木谷 友洋, 古江 秀昌, 吉村 恵, 並木 昭義

    PAIN RESEARCH　21　(2)　48-48　2006/07

    Publisher: 日本疼痛学会

    ISSN： 0915-8588

  81. DAMGOの脳室内投与に対するマウス延髄痛覚受容ニューロン活動の系統差 Peer-reviewed

    杉野 繁一, 川真田 樹人, 山内 正憲, 成松 英智, 並木 昭義

    PAIN RESEARCH　21　(2)　78-78　2006/07

    Publisher: 日本疼痛学会

    ISSN： 0915-8588

  82. 抗菌薬投与に関連するアナフィラキシー対策ガイドラインに基づく周術期管理 手術開始直後にアナフィラキシーショックとなった1症例 Peer-reviewed

    杉目 史行, 杉野 繁一, 岩崎 創史, 山内 正憲, 中山 雅康, 金谷 憲明, 並木 昭義

    北海道外科雑誌　51　(1)　83-83　2006/06

    Publisher: 北海道外科学会

    ISSN： 0288-7509

  83. 【小児区域麻酔のコツ】 小児硬膜外麻酔への超音波画像の利用 Peer-reviewed

    山内 正憲, 杉野 繁一

    LiSA　13　(5)　448-449　2006/05

    Publisher: (株)メディカル・サイエンス・インターナショナル

    ISSN： 1340-8836

    eISSN： 1883-5511

  84. 本学会ガイドラインに基づき治療しえた抗菌薬投与による手術中のアナフィラキシーショックの1症例 Peer-reviewed

    杉目 史行, 杉野 繁一, 岩崎 創史, 山内 正憲, 中山 雅康, 金谷 憲明, 小林 巌, 並木 昭義

    日本化学療法学会雑誌　54　(Suppl.A)　118-118　2006/04

    Publisher: (公社)日本化学療法学会

    ISSN： 1340-7007

    eISSN： 1884-5886

  85. 橈骨動脈ガイドワイヤー内蔵動脈カテーテル挿入時の超音波画像 Peer-reviewed

    山内 正憲, 中山 雅康, 平田 直之, 杉野 繁一, 阿部 純子, 金谷 憲明, 並木 昭義

    臨床モニター　17　(Suppl.)　57-57　2006/04

    Publisher: 医学図書出版(株)

    ISSN： 0915-6976

  86. perilaryngeal airway,ビデオ喉頭鏡を用いて管理したGoldenhar症候群の1症例 Peer-reviewed

    杉野 繁一, 金谷 憲明, 表 圭一, 並木 昭義

    麻酔　54　(12)　1367-1370　2005/12

    Publisher: 克誠堂出版(株)

    ISSN： 0021-4892

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    5歳3ヵ月,女児.出生時に顔面の変形,心奇形(心室中隔欠損,僧帽弁閉鎖不全),左母指低形成を指摘されGoldenhar症候群と診断された.左母指対立筋再建術を予定した.慢性副鼻腔炎で通院中であった.顔貌は左前額,下顎の低形成を認めたが,ほぼ正常でマスク保持は可能であると予想された.麻酔は全身麻酔を選択した.気道確保はPLAを用いることとした.十分な酸素化ののち,チアミラールを投与した.入眠後,マスクの保持は可能であった.亜酸化窒素とセボフルラン5%で十分に麻酔が深くなったあと,ビデオ喉頭鏡で試験的に咽頭内を観察した.声帯はディスプレー下で観察可能であり,緊急時に気管挿管は可能であると思われた.術中,著変を認めず,吸入麻酔薬を中止後,覚醒は速やかで,すぐにPLAを抜去することができた.術後の咽頭痛は認めなかった.術後は問題なく経過した

  87. 【パルスオキシメータ】 技術編 ここまで進化した技術・いまだ残る課題 Invited Peer-reviewed

    杉野 繁一, 金谷 憲明

    LiSA　12　(9)　792-798　2005/09

    Publisher: (株)メディカル・サイエンス・インターナショナル

    ISSN： 1340-8836

    eISSN： 1883-5511

  88. 臨床経験 根治的前立腺全摘除術における自己血輸血の検討 Peer-reviewed

    杉野 繁一, 七戸 康夫, 黒田 浩光

    麻酔　54　(7)　762-766　2005/07

    Publisher: 克誠堂出版

    ISSN： 0021-4892

  89. リトドリン過量投与により肺水腫を呈した無心胎双胎妊娠の1例 Peer-reviewed

    宮下 龍, 杉野 繁一, 黒田 浩光, 土屋 滋雄, 鎌田 康宏, 七戸 康夫, 並木 昭義

    北海道外科雑誌　50　(1)　82-83　2005/06

    Publisher: 北海道外科学会

    ISSN： 0288-7509

  90. 【体温のバイオロジー 体温はなぜ37℃なのか】 体温の生理学 暖かいと眠くなるのか?眠いから体温が上がるのか? Invited Peer-reviewed

    川真田 樹人, 高橋 稔之, 杉野 繁一

    LiSA　増刊　(体温バイオロジー体温はなぜ37℃なのか)　47-48　2005/04

    Publisher: (株)メディカル・サイエンス・インターナショナル

    ISSN： 1340-8836

    eISSN： 1883-5511

  91. アセチルサリチル酸と大量バルプロ酸ナトリウムの服用後に重症急性膵炎と急性肝不全を生じた1例 Peer-reviewed

    黒田 浩光, 土屋 滋雄, 杉野 繁一, 七戸 康夫, 山根 真央, 升田 好樹, 今泉 均

    日本救急医学会雑誌　16　(4)　163-168　2005/04

    Publisher: (一社)日本救急医学会

    DOI： 10.3893/jjaam.16.163 　

    ISSN： 0915-924X

    eISSN： 1883-3772

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    53歳男性.アセチルサリチル酸(ASA)と大量バルプロ酸ナトリウム(VPA)の服用後に重症急性膵炎と急性肝不全を生じた1例を経験した.自宅で妻とともに倒れているのを発見され救急搬入(妻は他院に)された.意識レベルはJCS300,嘔吐,尿失禁を認め,検査で高ナトリウム血症,高乳酸血症,高アンモニア血症を認めた.搬入8時間後に妻へのVPA処方が判明した.患者は循環血液量減少性ショック状態となり,ヒドロキシエチルデンプン投与で血圧は上昇した.搬入6時間後の血液検査でVPA血中濃度1555μg/ml,ASA濃度114μg/mlでVPA中毒と診断し,直接血液灌流(DHP)と血液濾過透析(HDF)を施行し,VPA血中濃度237μg/mlに低下し,意識レベルはJCS100まで改善した.第2病日に膵酵素と肝逸脱酵素の上昇,DICを認め,CTの肝部分壊死と膵全体壊死像から重症急性膵炎と診断した.HDF等の諸治療に反応せず,第3病日多臓器不全で死亡した

  92. 消化管穿破を伴った内腸骨動脈瘤破裂の1症例 Peer-reviewed

    杉野 繁一, 七戸 康夫, 黒田 浩光, 土屋 滋雄, 奥田 耕司, 浜田 弘巳, 並木 昭義

    日本救急医学会雑誌　16　(3)　115-120　2005/03

    Publisher: (一社)日本救急医学会

    DOI： 10.3893/jjaam.16.115 　

    ISSN： 0915-924X

    eISSN： 1883-3772

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    73歳男.大量下血をきたし,搬入時には出血性ショックを呈していた.腹部造影CTおよび血管造影にて,内腸骨動脈瘤破裂とその下部消化管穿破を疑い,止血と再破裂予防のため,2度の経カテーテル動脈塞栓術を施行した.その後イレウス症状が継続,術後5日目の腹部造影CTにて腹腔内遊離ガスを認め,緊急開腹術を施行した.術中所見にて直腸前壁に穿孔を認め同部位を切除,直腸断端を閉鎖し人工肛門を造設した.その4日後には腹腔内ドレーンから便臭を伴う多量の排液を認め,再開腹下に直腸を再切断し,腹腔内洗浄ドレナージ術を施行した.術中所見にて直腸断端部の離解を認め,腹膜炎を来したものと考えられた.術後,多臓器不全の合併なくICUを退室,その後数度の腹腔内膿瘍穿刺を要したが第48病日に外出可能となった.しかし翌日に右下腹部痛が出現,第50病日には救急車で搬送され,センター到着時には心肺停止状態であった.内腸骨動脈瘤再破裂による出血性ショックと思われ,心拍再開せず永眠した

  93. 集中治療における今後のDPCの運用 Peer-reviewed

    杉野 繁一, 七戸 康夫, 鎌田 康宏, 宮下 龍, 木村 陽, 川真田 樹人, 並木 昭義

    日本集中治療医学会雑誌　12　(Suppl.)　216-216　2005/01

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

    eISSN： 1882-966X

  94. オイグルコン,ディオバン大量服用の1例 Peer-reviewed

    和田 武志, 黒田 浩光, 七戸 康夫, 杉野 繁一, 土屋 滋雄, 浜田 浩巳, 奥田 耕司

    日本救急医学会雑誌　15　(9)　442-442　2004/09

    Publisher: (一社)日本救急医学会

    ISSN： 0915-924X

    eISSN： 1883-3772

  95. 大量下血により発症した内腸骨動脈瘤の1例 Peer-reviewed

    杉野 繁一, 七戸 康夫, 黒田 浩光, 土屋 滋雄, 奥田 耕司, 清水 隆文, 浜田 弘巳, 並木 昭義

    日本救急医学会雑誌　15　(9)　454-454　2004/09

    Publisher: (一社)日本救急医学会

    ISSN： 0915-924X

    eISSN： 1883-3772

  96. 医療遠隔地における鈍的腹部外傷患者に対する経カテーテル的動脈塞栓術の適応 25症例の検討 Peer-reviewed

    杉野 繁一, 荒川 穣二, 浅井 建基, 名和 由布子, 大森 英哉, 高橋 広巳, 松澤 徹, 並木 昭義

    日本腹部救急医学会雑誌　24　(5)　861-867　2004/07

    Publisher: (一社)日本腹部救急医学会

    DOI： 10.11231/jaem1993.24.861 　

    ISSN： 1340-2242

    eISSN： 1882-4781

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    8年6ヵ月間に鈍的腹部外傷に対して経カテーテル的動脈塞栓術(TAE)を施行した25例について検討し,urban areaと状況が違うrural areaでのTAEの適応範囲の拡大を提言した.Injury Severity Score(ISS)の平均は32であり,高エネルギー外傷が多く,緊急TAEとなった17例のうち12例でTAE前に輸血ができなかった.初期輸血に反応しなかった8例中,5例でTAEにより救命でき,3例でTAE後に外科的止血術を加えた.術中の血圧,心拍数は安定していた.rural areaでは輸血の準備に時間を要するため,循環動態が不安定な症例はTAEを施行し開腹止血術を行うことが最善であると考えられた

  97. バルプロ酸とアスピリンの大量服用による重症急性膵炎の一例 Peer-reviewed

    黒田 浩光, 土屋 滋雄, 杉野 繁一, 七戸 康夫

    日本臨床救急医学会雑誌　7　(2)　196-196　2004/04

    Publisher: (一社)日本臨床救急医学会

    ISSN： 1345-0581

    eISSN： 2187-9001

  98. 当院における救命処置教育プログラムの現状と今後のあり方 Peer-reviewed

    土屋 滋雄, 黒田 浩光, 杉野 繁一, 七戸 康夫

    麻酔　53　(2)　225-225　2004/02

    Publisher: 克誠堂出版(株)

    ISSN： 0021-4892

  99. 平坦脳波と判定できなかった臨床的に脳死の1例 Peer-reviewed

    杉野 繁一, 七戸 康夫, 黒田 浩光, 土屋 滋雄, 望月 孝史, 並木 昭義

    日本集中治療医学会雑誌　11　(Suppl.)　163-163　2004/01

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

    eISSN： 1882-966X

  100. 当院における心肺蘇生教育チームの活動 Peer-reviewed

    七戸 康夫, 前田 利昭, 名和 由布子, 土屋 滋夫, 杉野 繁一, 黒田 浩光

    日本救急医学会雑誌　14　(10)　568-568　2003/10

    Publisher: (一社)日本救急医学会

    ISSN： 0915-924X

    eISSN： 1883-3772

  101. 気管分岐異常を有する患者の肺切除術の麻酔経験 Peer-reviewed

    竹元 暁, 川真田 樹人, 杉野 繁一, 並木 昭義

    臨床麻酔　27　(6)　1047-1048　2003/06

    Publisher: 真興交易(株)医書出版部

    ISSN： 0387-3668

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    68歳女.右肺癌に対し,胸腔鏡下肺切除術(VATS)を予定した.血圧は150/68mmHgと高値で,胸部X線検査では分岐異常は不明瞭であった.しかし,胸部CTで気管分岐異常が指摘されていたため,前投薬としてゾピクロンを経口投与し,心電図,非観血的血圧,観血的動脈圧,SPO2をモニターし,手術室入室後,T4/5より硬膜外カテーテルを挿入留置した.プロポフォール80mgを静注投与で導入し,ベクロニウムを用い,左用二腔気管チューブを挿管し,.挿管後,気管支ファイバーで気管内を観察し,気管分岐部手前1cmの部位に右上葉支が確認された.腫瘍は右上葉であったため,挿管チューブを深めに留置しカフで閉塞した.硬膜外腔へ1.5%リドカイン間欠投与,酸素33%,亜酸化窒素66%,セボフルラン0.1〜1.6%で維持し,分離肺換気中は低酸素血症に陥ることもなく,麻酔時間8時間30分,出血量500mlで手術を終えた

  102. 溺水蘇生後に不随意運動を伴ったneurofibromatosis type 1小児の1症例 Peer-reviewed

    杉野 繁一, 山崎 裕, 名和 由布子, 佐藤 公一, 其田 一, 並木 昭義

    日本集中治療医学会雑誌　9　(4)　399-402　2002/10

    Publisher: (一社)日本集中治療医学会

    DOI： 10.3918/jsicm.9.399 　

    ISSN： 1340-7988

    eISSN： 1882-966X

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    14歳男.釣りの準備中に突然意識を消失し海へ転落した.水没後約15分で救助されたが,救助者による心肺蘇生は施行されなかった.水温は9℃であった.救急隊が到着した時は心肺停止状態であり,直ちに一次救命処置を開始して搬送された.二次救命処置及び復温を施行し,エピネフリン,硫酸アトロピン,リドカインを投与して,搬入45分後に心拍が再開してICUに収容した.蘇生後の神経学的回復を期待し,前額温が30.2℃,直腸温が32.9℃と低体温でもあったことから,復温せずに軽度脳低温療法に移行した.第2病日には対光反射が出現した.第3病日の頭部CTには軽度の脳浮腫を認めたが頭蓋内占拠性病変はなかった.頭部MRIではT2強調画像で大脳基底核に高信号域を認めた.第4病日より復温を開始した.4ヵ月後の現在,会話は支障なく車椅子で移動できる程度に回復した

  103. シャルコー・マリー・トゥース病患者に対するプロポフォール 亜酸化窒素による麻酔経験 Peer-reviewed

    杉野 繁一, 山崎 裕, 名和 由布子, 佐藤 公一, 其田 一, 並木 昭義

    麻酔　51　(9)　1016-1019　2002/09

    Publisher: 克誠堂出版(株)

    ISSN： 0021-4892

    More details Close

    65歳女.CMTDを有する患者の腹臥位手術を,プロポフォールと亜酸化窒素と少量のフェンタニルを用いて麻酔管理を行った.腹臥位であり気管挿管は必須と考えた.亜酸化窒素は静脈麻酔薬の減量と鎮痛作用を期待して用いた.術前の呼吸機能は良好であったが,鎮静薬投与による呼吸抑制を避ける為,前投薬は用いなかった.術中は著変なく経過したが,腹臥位であり気管管理には十分な注意が必要であった.本症例においてもプロポフォール持続投与を中止して10分後に抜管できる状態になった.覚醒が速やかで,全身麻酔維持にも使用できるプロポフォールはこのような神経筋疾患に対して有用と考えられた

  104. 加温はpropofolの心要入眠量を減少させる? Peer-reviewed

    杉野 繁一, 川真田 樹人, 並木 昭義

    臨床体温　20　(1)　56-56　2002/08

    Publisher: 「臨床体温」編集委員会

  105. TTP/HUSとの鑑別を要したITPの1症例 Peer-reviewed

    杉野 繁一, 大森 英哉, 浅井 健基, 名和 由布子, 高橋 広巳, 荒川 穣二, 並木 昭義

    北海道外科雑誌　47　(1)　89-89　2002/06

    Publisher: 北海道外科学会

    ISSN： 0288-7509

  106. 授乳中の乳房トラブルに対する直線偏光近赤外線照射の試み Peer-reviewed

    名和 由布子, 大森 英哉, 浅井 建基, 杉野 繁一, 高橋 広巳, 荒川 穣二

    日本ペインクリニック学会誌　9　(3)　294-294　2002/06

    Publisher: (一社)日本ペインクリニック学会

    ISSN： 1340-4903

    eISSN： 1884-1791

  107. 骨形成不全症患者の麻酔経験 Peer-reviewed

    浅井 建基, 大森 英哉, 名和田 布子, 杉野 繁一, 高橋 広巳, 荒川 穣二

    麻酔　51　(4)　445-445　2002/04

    Publisher: 克誠堂出版(株)

    ISSN： 0021-4892

  108. Epiduroscopyが無効であったが椎間板加圧注射にて症状緩解を得た腰下肢痛の1例 Peer-reviewed

    大森 英哉, 荒川 穣二, 高橋 広巳, 杉野 繁一, 名和 由布子, 浅井 建基

    ペインクリニック　23　(1)　108-109　2002/01

    Publisher: 真興交易(株)医書出版部

    ISSN： 0388-4171

  109. 意識消失で発症したneurofibromatosis type1の溺水の1例 Peer-reviewed

    杉野 繁一, 山崎 裕, 名和 由布子, 佐藤 公一, 其田 一, 松谷 学, 早田 航, 足立 憲昭, 並木 昭義

    日本集中治療医学会雑誌　8　(Suppl.)　234-234　2001/01

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

    eISSN： 1882-966X

  110. CABG手術中に発症したアナフィラキシー様ショックの1例 Peer-reviewed

    杉野 繁一, 小北 直宏, 黒沢 さおり, 岡沼 水緒子, 一宮 尚裕

    北海道外科雑誌　45　(1)　95-95　2000/06

    Publisher: 北海道外科学会

    ISSN： 0288-7509

  111. 深部静脈血栓症の既往のある妊婦に対して一時的下大静脈フィルタを用いて帝王切開術を施行した1症例 Peer-reviewed

    杉野 繁一, 今泉 均, 七戸 康夫, 四十物 摩呼, 並木 昭義

    麻酔　49　(3)　295-297　2000/03

    Publisher: 克誠堂出版(株)

    ISSN： 0021-4892

  112. 肺切除後に急性増悪した特発性間質性肺炎の1症例 Peer-reviewed

    杉野 繁一, 金谷 憲明, 並木 昭義

    麻酔　49　(2)　187-190　2000/02

    Publisher: 克誠堂出版(株)

    ISSN： 0021-4892

  113. 開心術後患者の鎮静におけるプロポフォールとミダゾラムの比較 Peer-reviewed

    黒沢 さおり, 小北 直宏, 杉野 繁一, 岡沼 水緒子, 一宮 尚裕, 並木 昭義

    日本集中治療医学会雑誌　7　(Suppl.)　147-147　2000/01

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

    eISSN： 1882-966X

Show all ︎Show first 5

Presentations 80

  1. 生成AIを基礎研究にどう組み込むのか？ Invited

    杉野繁一

    日本区域麻酔学会第11回学術集会　2024/04

  2. PONV研究：過去・現在・未来 Invited

    杉野繁一

    日本区域麻酔学会第11回学術集会　2024/04

  3. Genetic and genomic mechanisms of perioperative complications in anesthesia care Invited

    Sugino Shigekazu

    The 69th Annual Meeting of Japanese Society of Anesthesiologists　2022

  4. Fantastic protocols by fantastic guidelines of EQUATOR network Invited

    Sugino Shigekazu

    The 40th Annual Meeting of Japanese Society for Clinical Anesthesia　2021

  5. Chronic Postsurgical pain in Elderly Patients Invited

    Shigekazu Sugino, Jun Suzuki

    The 40th Annual Meeting of Japanese Society for Clinical Anesthesia　2020/11/06

  6. The effects of a high-fat diet on a postoperative pain model in rat

    Kido K, Katagiri N, Sugino S, Sanuki T

    Euroanaesthesia 2024　2024/05

  7. Gamma Oscillations of Electroencephalogram after Applications of Electrical Stimulation: A Preliminary Volunteer Study

    Mashima T, Kamata K, Lipping T, Sugino S, Hagihira S, Yamauchi M

    Euroanaesthesia 2024　2024/05

  8. Factors affecting the occurence of fetal bradycardia after neuraxial labor analgesia: a retrospective observational study

    Sekine T, Sugino S, Nakagawa M, Niihara A, Yamauchi M

    Euroanaesthesia 2024　2024/05

  9. Analgesic effect and safety of programmed intermittent bolus infusion concomitant with serratus anterior plane block for minimally invasive cardiac surgery: A randomized, double-blind controlled trial

    Sato Y, Kumagai M, Kaiho Y, Sugino S, Ito J, Yamauchi M

    Euroanaesthesia 2023　2023

  10. Learning curve to correct identification of the vertebral interspace for epidural puncture by ultrasound imaging validation

    Mashima T, Sugino S, Tamii T, Okada Y, Kamata K, Yamauchi M

    Euroanaesthesia 2023　2023

  11. Backcross of shrews for discovering genetic factors to prevent postoperative nausea and vomiting: a preliminary study

    Sekine T, Sugino S, Konno D, Suzuki J, Kamata K, Yamauchi M

    Euroanaesthesia 2023　2023

  12. Efficacy of programmed intermittent bolus infusion with serratus anterior plane block catheter for analgesia in the intensive care unit after minimally invasive cardiac surgery: A randomized, doubleblind, controlled trial

    Sato Y, Kumagai M, Kaiho Y, Taguri M, Sekine T, Takei Y, Sugino S, Inoue H, Ito J, Yamauchi M

    35th ESICM Annual Congress　2022

  13. Successful recording of direct cortical motor evoked potential from a paediatric patient under remimazolam anaesthesia

    Kamata K, Asagi S, Shimoda Y, Kanamori M, Abe N, Sugino S, Tominaga M, Yamauchi M

    SSAI 2022 Congress　2022

  14. Delayed emergence from general anesthesia followed by genomic analysis: clinical whole-exome sequencing in a family trio

    Oishi W, Sugino S, Murakami M, Hiratsuka M, Yamauchi M

    American Society of Anesthesiologists Annual Meeting　2022

  15. Relationship between preoperative procalcitonin level and the severity of strangulated ileus

    Sumida H, Takei Y, Sugino S, Yamauchi M

    American Society of Anesthesiologists Annual Meeting　2021

  16. Enhancement of contrast between a local anesthetic and tissue in ultrasound-guided rectus sheath block by using perflubutane microbubbles: a prospective observational study

    Onishi E, Sugino S, Saito K, Kumagai M, Oba R, Murakami T, Yamauchi M

    American Society of Anesthesiologists Annual Meeting　2021

  17. EGR1 gene expression in the nucleus of the solitary tract in a shrew model of postoperative nausea and vomiting International-presentation

    Konno D, Sugino S, Misawa K, Shibata FT, Janicki PK, Imamura-Kawasawa Y, Kido K, Nagasaki M, Yamauchi M

    American Society of Anesthesiologists Annual Meeting　2019

  18. Effect of forced-air warming by an underbody blanket on patients undergoing gynecological surgery: a prospective double-blinded randomized controlled study International-presentation

    Okamoto A, Konno D, Sugino S, Kuratani N, Suzuki J, Sumida H, Yamauchi M

    American Society of Anesthesiologists Annual Meeting　2019

  19. Anesthetic management and following genomic analysis in a patient with congenital insensitivity to pain with anhidrosis International-presentation

    Suzuki J, Sugino S, Yamamoto T, Konno D, Imamura-Kawasawa Y, Yamauchi M

    American Society of Anesthesiologists Annual Meeting　2019

  20. Effect of forced-air warming by an underbody-type blanket in surgical patients after anesthetic induction: general piecewise linear mixed effects model International-presentation

    Sato K, Kuratani N, Sugino S, Sumida H, Sato Y, Yamauchi M

    Euroanaesthesia 2019　2019

  21. Whole transcriptome profiling in the nucleus of the solitary tract for antiemetic drug discovery in a rat model of postoperative nausea and vomiting International-presentation

    Abe J, Sugino S, Konno D, Imamura-Kawasawa Y, Kido K, Yamauchi M

    Euroanaesthesia 2019　2019

  22. Optimal Postoperative Analgesia after Complete Video-assisted Thoracoscopic Surgery: A Propensity Score-matched Analysis International-presentation

    Suzuki J, Sugino S, Kameyama Y, Shiga T, Saito K, Yamauchi M

    American Society of Anesthesiologists Annual Meeting　2018

  23. Epidural Analgesia in patients who have undergone video-assisted thoracoscopic surgery prevents a breakthrough pain in the intensive care unit International-presentation

    Suzuki J, Shiga T, Sugino S, Kameyama Y, Saito K, Yamauchi M

    31st ESICM Annual Congress　2018

  24. Nine candidate genes involved in postoperative nausea and vomiting: transcriptome analysis in the nucleus of the solitary tract of the musk shrew International-presentation

    Konno D, Sugino S, Shibata FT, Misawa K, Imamura-Kawasawa Y, Kido K, Nagasaki M, Yamauchi M

    Neuroscience Meeting　2018

  25. A novel rat model of neuropathic pain by camping the sciatic nerve for cell transplantation International-presentation

    Kumagai M, Murakami T, Obata H, Sugino S, Yamauchi M

    American Society of Anesthesiologists Annual Meeting　2017

  26. Sequential non-invasive positive pressure ventilation after failed high-flow oxygen therapy through a nasal cannula in critically ill patients International-presentation

    Konno D, Sugino S, Saito K, Muraki H, Tamii T, Murakami T, Kameyama Y, Hoshi K, Yamauchi M

    American Society of Anesthesiologists Annual Meeting　2017

  27. Long non-coding RNA MIR4300HG polymorphisms are involved in postoperative nausea and vomiting in the Japanese population: genome-wide association study International-presentation

    Konno D, Sugino S, Kawai Y, Nagasaki M, Yamauchi M

    American Society of Anesthesiologists Annual Meeting　2017

  28. Polymorphisms of HTR2C gene are associated with diffrences in basal and post-handling cortisols in preterm infants International-presentation

    Doheny KK, Gardner FC, Teti DM, Palmer C, Sugino S, Janicki PK

    Pediatric Academic Societies Meeting　2016

  29. Reduction in infusion and blood transfusion with robot-assisted laparoscopic prostatectomy International-presentation

    Saito H, Sugino S, Kuratani N, Yamauchi M

    American Society of Anesthesiologists Annual Meeting　2016

  30. Effects of forced-air warming by an underbody-type blanket: a propensity score-matched analysis International-presentation

    Sumida H, Sugino S, Kuratani N, Konno D, Hasegawa J, Yamauchi M

    American Society of Anesthesiologists Annual Meeting　2016

  31. Factors affecting the time to extubation following pediatric ambulatory surgery: an analysis using electric anesthesia record data in an academic university hospital International-presentation

    Kanaya A, Sugino S, Kuratani N, Kaiho Y, Yamauchi M

    American Society of Anesthesiologists Annual Meeting　2015

  32. De novo assembly of musk shrew hindbrain transcriptome and comparison of gene expressions in animals with high and low incidence of postanesthesia nausea and vomiting International-presentation

    Sugino S, Horn CC, Janicki PK

    American Society of Anesthesiologists Annual Meeting　2014

  33. Voltage-dependent inhibition of Ca2+ currents mediated by substance P-stimulated neurokinin-1 receptors in rat celiac-superior mesenteric ganglion neurons International-presentation

    Sugino S, Farrag M, Ruiz-Velasco V

    Neuroscience Meeting　2014

  34. Recovery of postoperative cognitive function in elderly patients after a long duration of desfluraneanesthesia International-presentation

    Kazuma S, Hayase T, Osuda M, Sugino S, Yamakage M

    American Society of Anesthesiologists Annual Meeting　2013

  35. Oprm1 gene polymorphism reduces DNA methylation at the upstream CpG island in male patients International-presentation

    Sugino S, Hayase T, Higuchi M, Nawa Y, Kumeta Y, Yamakage M

    American Society of Anesthesiologists Annual Meeting　2013

  36. Association of μ-Opioid Receptor Gene (OPRM1) Haplotypes with Postoperative Nausea and Vomiting (PONV) during Intravenous Patient-Controlled Analgesia International-presentation

    Sugino S, Hayase T, Higuchi M, Kumeta Y, Namiki A, Yamakage M

    Biology of Control of Nausea and Vomiting　2013

  37. Quality improvement in generic sevoflurane product using gas chromatography International-presentation

    Tachibana S, Hayase T, Sugino S, Sonoda H, Yamakage M

    American Society of Anesthesiologists Annual Meeting　2012

  38. CHRM3 gene polymorphism is associated with postoperative nausea and vomiting in the Japanese population International-presentation

    Hayashi H, Sugino S, Hayase T, Nawa Y, Yamakage M

    American Society of Anesthesiologists Annual Meeting　2012

  39. Involvement of HTR3C gene polymorphisms in postoperative pain in lower abdominal surgery International-presentation

    Hayashi H, Sugino S, Hayase T, Nawa Y, Yamakage M

    American Society of Anesthesiologists Annual Meeting　2012

  40. Haplotypes in human TACR1 gene are associated with postoperative nausea and vomiting International-presentation

    Hayase T, Sugino S, Tachibana S, Kumeta Y, Yamakage M

    American Society of Anesthesiologists Annual Meeting　2012

  41. Predictors of occurrence of postoperative vomiting in children with microtia International-presentation

    Kawaguchi R, Sugino S, Hirata N, Suzuki N, Yamakage M

    American Society of Anesthesiologists Annual Meeting　2012

  42. Efficacy and safety of mixtures of lidocaine and ropivacaine for scalp block in patients undergoing awake craniotomy International-presentation

    Chaki T, Sugino S, Ishioka Y, Yamashita M, Yamakage M

    American Society of Anesthesiologists Annual Meeting　2012

  43. Changes in motor-evoked potentials do not reflect the spinal cord ischemia in thoracicoabdominal aortic aneurysm surgery with deep hypothermic circulatory arrest International-presentation

    Kimijima T, Sugino S, Miyashita R, Masuda Y, Imaizumi H, Yamakage M

    Euroanaesthesia　2011

  44. Incidence of emesis after epidural infusion of fentanyl/ropivacaine did not depend on the blood concentration measured by using LC-MS/MS analysis International-presentation

    Tachibana S, Hayase T, Sugino S, Kumeta Y, Yamakage M

    American Society of Anesthesiologists Annual Meeting　2011

  45. Performance of a novel portable epoc? analyzer for arterial blood gas testing International-presentation

    Tachibana S, Sugino S, Ishioka Y, Hayase T, Yamakage M

    American Society of Anesthesiologists Annual Meeting　2011

  46. Improved noninvasive total hemoglobin measurements after in vivo adjustment International-presentation

    Miyashita R, Sugino S, Niiyama Y, Mimura M, Yamakage M

    American Society of Anesthesiologists Annual Meeting　2011

  47. Accuracy of noninvasive total hemoglobin measurement after acute normovolemic hemodilution in urological surgical patients International-presentation

    Miyashita R, Sugino S, Tanabe M, Mimura M, Yamakage M

    American Society of Anesthesiologists Annual Meeting　2011

  48. Genetic variation in human TACR1 gene is associated with postoperative nausea and vomiting International-presentation

    Hayase T, Sugino S, Tachibana S, Satoh M, Yamakage M

    American Society of Anesthesiologists Annual Meeting　2011

  49. Accuracy of recording auditory evoked potentials from the nose and mandible to monitor awareness International-presentation

    Ishioka Y, Hayase T, Sugino S, Takahashi K, Yamakage M

    American Society of Anesthesiologists Annual Meeting　2011

  50. Novel treatment of severe tetanus with gabapentin in a mechanically ventilated patient International-presentation

    Tachibana S, Sugino S, Hayase T, Kumeta Y, Namiki A, Yamakage M

    13th Asian Australasian Congress of Anesthesiologists　2010

  51. Prediction of hypotension after epidural infusion from early changes in stroke volume Index International-presentation

    Hayase T, Sugino S, Nakabayashi K-I, Kumeta Y, Namiki A

    American Society of Anesthesiologists Annual Meeting　2010

  52. Haplotypes in human mu-opioid receptor gene associated with postoperative nausea and vomiting International-presentation

    Hayase T, Sugino S, Higuchi M, Kumeta Y, Yamakage M

    American Society of Anesthesiologists Annual Meeting　2010

  53. Area of Less Than 80 mm2 at the L3-4 vertebral interspace predicts difficult spinal puncture International-presentation

    Higuchi M, Sugino S, Hayase T, Kumeta Y, Namiki A

    American Society of Anesthesiologists Annual Meeting　2009

  54. Evaluation of a new reusable skin-protective sphygmomanometer cuff International-presentation

    Gi E, Watanabe H, Sugino S, Arakawa J, Namiki A

    American Society of Anesthesiologists Annual Meeting　2008

  55. Emergency percutaneous dilational tracheostomy with transtracheal jet ventilation International-presentation

    Seki S, Sugino S, Yamauchi M, Yamakage M, Namiki A

    American Society of Anesthesiologists Annual Meeting　2008

  56. Strain differences in the response of rostral ventromedial medulla neurons to DAMGO in inbred mice International-presentation

    Sugino S, Kawamata M, Higuchi M, Kumeta Y, Namiki A

    American Society of Anesthesiologists Annual Meeting　2008

  57. Quantification of workload and profit of each anesthesiologist using an electronic anesthesia record International-presentation

    Kawaguchi R, Sugino S, Yamauchi M, Yamakage M, Namiki A

    American Society of Anesthesiologists Annual Meeting　2007

  58. Ultrasound-guided unilateral epidural anesthesia for lower extremity surgery International-presentation

    Kawaguchi R, Yamauchi M, Sugino S, Asano M, Namiki A

    American Society of Anesthesiologists Annual Meeting　2007

  59. Clinical assessment of tracheal intubation using an airwayscope video laryngoscope International-presentation

    Saijo H, Sugino S, Kanaya N, Nakayama Y, Namiki A

    American Society of Anesthesiologists Annual Meeting　2007

  60. Spinal morphine exacerbates motor dysfunction after traumatic spinal cord contusion International-presentation

    Sugiyama Y, Kawamata M, Sugino S, Terashima Y, Narimatsu E, Namiki A

    Neuroscience Meeting　2007

  61. Changes in synaptic transmission in substantia gelatinosa neurons after application of mustard oil International-presentation

    Kawamata M, Sugino S, Kiya T, Sugiyama Y, Yamauchi M, Narimatsu E, Namiki A

    Neuroscience Meeting　2007

  62. Changes in physiological properties of rostral ventromedial medulla neurons after surgical incision in mouse inbred strains International-presentation

    Sugino S, Kawamata M, Sugiyama Y, Terashima Y, Yamauchi M, Narimatsu E, Namiki A

    Neuroscience Meeting　2007

  63. Clinical evaluation of a new video laryngoscope (airwayscope) for tracheal intubation International-presentation

    Saijo H, Sugino S, Kanaya N, Watanabe H, Namiki A

    Euroanaesthesia　2007

  64. Ultrasound-guided pediatric epidural anesthesia in the Nuss procedure for pectus excavatum International-presentation

    Sugino S, Kanaya N, Yamauchi M, Tsukigase N, Namiki A

    Euroanaesthesia　2007

  65. Nitrous oxide does not affect amplitude of motor-evoked potentials International-presentation

    Kawamata M, Narimatsu E, Yamauchi M, Sugino S, Namiki A

    American Society of Anesthesiologists Annual Meeting　2006

  66. Properties of substantia gelatinosa neurons in neonatal rats by in vivo patch-clamp analysis International-presentation

    Kawamata M, Sugino S, Narimatsu E, Kiya T, Namiki A

    American Society of Anesthesiologists Annual Meeting　2006

  67. Changes in synaptic transmission in substantia gelatinosa neurons activation of TRPA1 International-presentation

    Kawamata M, Sugino S, Kiya T, Narimatsu E, Namiki A

    American Society of Anesthesiologists Annual Meeting　2006

  68. Changes in synaptic transmission in substantia gelatinosa neurons after surgical injury International-presentation

    Yamauchi M, Kawamata M, Narimatsu E, Sugino S, Namiki A

    American Society of Anesthesiologists Annual Meeting　2006

  69. Response properties of substantia gelatinosa neurons in different strains of mice after incision International-presentation

    Kawamata M, Sugino S, Yamauchi M, Kiya T, Namiki A

    American Society of Anesthesiologists Annual Meeting　2006

  70. Ultrasound-guided pediatric epidural anesthesia in the Nuss procedure for pectus excavatum International-presentation

    Tsukigase N, Sugino S, Yamauchi M, Asano M, Namiki A

    American Society of Anesthesiologists Annual Meeting　2006

  71. Changes in properties of rostral ventromedial medulla neurons after skin incision in mouse strains International-presentation

    Sugino S, Kawamata M, Yamauchi M, Narimatsu E, Namiki A

    American Society of Anesthesiologists Annual Meeting　2006

  72. Differences in action potentials of spinal dorsal horn neurons after transient spinal cord ischemia in the rat International-presentation

    Sugino S, Kawamata M, Yamauchi M, Narimatsu E, Namiki A

    American Society of Anesthesiologists Annual Meeting　2006

  73. Physiological properties of substantia gelatinosa neurons in neonatal rats by in vivo patch-clamp analysis International-presentation

    Kawamata M, Narimatsu E, Sugino S, Kiya T, Namiki A

    Neuroscience Meeting　2006

  74. Genetic differences in responses of rostral ventromedial medulla neurons induced by DAMGO, μ-opioid receptor agonist in mouse inbred strains International-presentation

    Sugino S, Kawamata M, Yamauchi M, Narimatsu E, Namiki A

    Neuroscience Meeting　2006

  75. Real-time monitoring of release of glutamate with neuronal activity in the spinal dorsal horn before, during and after spinal cord ischemia International-presentation

    Takahashi T, Sugino S, Niiya T, Narimatsu E, Namiki A?

    American Society of Anesthesiologists Annual Meeting　2005

  76. Response properties of superficial dorsal horn neurons of the spinal cord in different strains of mice following surgical incision International-presentation

    Kawamata M, Kiya T, Sugino S, Narimatsu E, Namiki A

    Neuroscience Meeting　2005

  77. Differences in action potentials of spinal dorsal horn neurons after transient spinal cord ischemia International-presentation

    Sugino S, Kawamata M, Narimatsu E, Namiki A

    Neuroscience Meeting　2005

  78. Evaluation of the neurological l outcome with nuclear images (SPECT, PET) during hypothermic therapy in patients with hypoxic brain damage International-presentation

    Sugino S, Shichinohe Y, Kuroda H, Tsuchiya S, Mochizuki T, Imaizumi H, Kawamata M, Namiki A

    13th Congress of the Western Pacific Association of Critical Care Medicine　2004

  79. Clinical evaluation of a new forehead pulse oximeter during general anesthesia International-presentation

    Kanaya N, Sugino S, Nakayama M, Kurosawa S, Namiki A

    American Society of Anesthesiologists Annual Meeting　2003

  80. Effect of warming on propofol requirement for loss of consciousness International-presentation

    Sugino S, Kawamata M, Takemoto A, Yamakage M, Namiki A

    American Society of Anesthesiologists Annual Meeting　2003

Show all Show first 5

Research Projects 28

  1. Development of a New Postoperative Analgesic Using Neuroregenerative Nanoparticles

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2025/04 - 2030/03

  2. 実験動物スンクスの悪心認知メカニズムの解明

    杉野 繁一

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 挑戦的研究(萌芽)

    Institution: 東北大学

    2025/06/27 - 2028/03/31

  3. Design and Development of an EEG-Based Monitoring System for Intraoperative Pain

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2025/04 - 2028/03

  4. 周術期唾液マルチオミックス解析を用いた術後せん妄バイオマーカーの探索

    新田 幸絵, 杉野 繁一, 杉本 昌弘, 城戸 幹太

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 北海道大学

    2025/04 - 2028/03

  5. 新しいラットモデルを用いた術後痛遷延化の分子遺伝メカニズムの解明と治療戦略の開発

    城戸 幹太, 杉野 繁一, 讃岐 拓郎, 渋谷 真希子, 新田 幸絵

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 北海道大学

    2023/04/01 - 2026/03/31

  6. Suncus Research for Elucidating the Genetic Mechanism in Postoperative Nausea and Vomiting

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2021/04/01 - 2026/03/31

  7. Suncus Research for Elucidating the Genetic Mechanism in Postoperative Nausea and Vomiting

    Shigekazu Sugino, Ichiro Miyoshi, Hideki Noguchi, Daisuke Konno

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2021/04 - 2026/03

  8. Novel Rat Model and Intervention for Elucidating the Molecular Mechanism in Chronic Postsurgical Pain

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2021/04/01 - 2025/03/31

  9. Quantification of Nociceptive Pain by EEG Gamma Oscillations in the Primary Somatosensory Cortex for Precision Postoperative Analgesia

    Kotoe Kamata, Shigekazu Sugino, Toru Murakami, Kanta Kido, Satoshi Hagihira, Masanori Yamauchi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2022/04 - 2025/03

  10. Novel Rat Model and Intervention for Elucidating the Molecular Mechanism in Chronic Postsurgical Pain

    Masanori Yamauchi, Shigekazu Sugino, Kanta Kido, Tetsuya Kodama, Yoshinori Okada

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2021/04 - 2025/03

  11. Development of Adverse Events-free Local Anesthetics in Cryo-EM Structural Determination of Sodium Channels

    Masanori Yamauchi, Shigekazu Sugino, Takafumi Suzuki, Kengo Kinoshita

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Challenging Research (Exploratory)

    Category: Grants-in-Aid for Scientific Research Challenging Research (Exploratory)

    Institution: Tohoku University

    2021/07 - 2024/03

  12. Single-cell Whole-transcriptome Analysis in Rat Basal Forebrain for Elucidating the Molecular Mechanism in Postoperative Delirium

    Daisuke Konno, Shigekazu Sugino

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Early-Career Scientists

    Category: Grant-in-Aid for Early-Career Scientists

    Institution: Tohoku University

    2021/04 - 2024/03

  13. Backcross of inbred Suncus for Elucidating the Genetic Mechanism in Postoperative Nausea and Vomiting

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Challenging Research (Exploratory)

    Category: Challenging Research (Exploratory)

    Institution: Tohoku University

    2019/06/28 - 2022/03/31

  14. High-fat diet increases postoperative pain in rats

    Kido Kanta

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Kanagawa Dental College

    2019/04/01 - 2022/03/31

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    In the present study, obese rats induced by high-fat diet intake had enhanced and prolonged postoperative pain including elevated spontaneous pain score and lower mechanical threshold. Transcriptome analysis of peripheral and central nervous tissue revealed no major gene expression changes in the spinal cord and 19 gene expression changes in the dorsal root ganglia. Increased peripheral sensitization by genes related to lipid metabolism was suggested as one of the mechanisms by which obesity enhances postoperative pain.

  15. Treatment strategy for severe COVID-19 induced coagulopathy based on the specific mechanisms

    Koji Saito, Masanori Yamauchi, Yusuke Takei, Yudai Iwasaki, Shigekazu Sugino

    Offer Organization: Japan Agency for Medical Research and Development

    System: Basic Research on Infectious Diseases including COVID-19

    Institution: Tohoku University, Dept. of Anesthesiology and Perioperative Medicine

    2020/08 - 2021/03

  16. Development of Multimodal Practice Guideline for Frozen Shoulder Focusing on Personalized Rehabilitation after Selective Nerve Block and Evaluation of Therapeutic Effects

    Masanori Yamauchi Yosuke Usui Shigekazu Sugino Nobuyuki Yamamoto Shin-ichi Konno

    Offer Organization: Japan Agency for Medical Research and Development

    System: Research Project on Elucidation of Chronic Pain

    Institution: Tohoku University, Dept. of Anesthesiology and Perioperative Medicine

    2018/04 - 2021/03

  17. Genome-wide linc RNA analysis in patients with neuropathic pain

    Yamauchi Masanori

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2017/04 - 2021/03

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    Chronic postsurgical pain (CPSP) is an unpleasant complication after surgery. However, the molecular genetic mechanisms underlying CPSP have not been fully elucidated. The aims of this study were to determine the whole genome-wide change in long non-coding RNA gene expression in the rat spinal cord and dorsal root ganglions and to try to determine the involvement of long non-coding RNAs in CPSP. The results of a behavioral study showed that pain-related behaviors persisted for over 60 days in the CPSP model rat but not in sham-operated rats. Whole transcriptome sequencing showed that AABR07007055.1 gene expression was significantly increased in both spinal cord and dorsal root ganglions of the CPSP model. We focused on AABR07007055.1 gene as a candidate associated with CPSP. The findings suggested that the change in AABR07007055.1 gene expression level may be involved in the molecular mechanisms underlying the development of CPSP.

  18. Development of antiemetic drugs for PONV by genome-wide long non-coding RNAs analysis

    Endo Yasuhiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2017/04/01 - 2020/03/31

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    Postoperative nausea and vomiting (PONV) is a serious complication after emergence from general anesthesia. However, previous findings are not widely applicable to different populations because of population-specific genetic variation. We developed a Japanese-specific DNA microarray for high-throughput genotyping. The aim of the current study is to identify causal SNPs associated with PONV on a genome-wide scale using this microarray in a sample of Japanese surgical patients. The results of the study showed that T > C variant of rs11232965 in the long non-coding RNA MIR4300HG was significantly associated with reduced incidence of PONV among genotypes and between alleles (p = 0.01 and 0.007). The findings suggested that the rs11232965-SNP variant (T > C) is protective against the incidence of PONV.

  19. Novel strategy for intensive care by using application of artificial intelligence to data mining of Diagnosis Procedure Combination payment system

    Shiga Takuya, IKUMI saori, KOBAYASHI naoya, SUGINO shigekazu, SAITO koji, NAKAYAMA masaharu, FUJIMORI kenji, YAMAUCHI masanori

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2017/04/01 - 2019/03/31

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    I constructed integrated big data in the intensive care unit (ICU) of Tohoku University Hospital, analyzed the relationship between the severity and the cost of each patient in the ICU. I planned to develop the original algorithm to derive the optimal treatments that would achieve optimal medical resource distribution and maximum medical benefits, depending on the changes in each patient's condition of severity. I set up a server to construct panel database. In regards to the patient’s severity, I gathered the ICU system data, and bed-side monitoring data of each patients admitted to our ICU for the past five years. In regards to the cost, I gathered material cost, labor cost, expense data, medical record and DPC/PDPS data with the cooperation of the university hospital medical affairs department. I cleaned and integrated the all above data, transferred to my server, and constructed the panel database. Finally, I calculated departmental costing and cost forecasting with this database.

  20. 補完的全ゲノム関連解析による小児の覚醒時興奮の分子基盤の解明

    蔵谷 紀文, 杉野 繁一

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(C)

    Category: 基盤研究(C)

    Institution: 東北大学

    2016/04/01 - 2019/03/31

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    平成28年度は遺伝子実験の環境整備と陽性対照実験の実施のみで終了した．分子遺伝実験環境に問題がないことを確認できた．平成29年度は詳細な研究プロトコルを最終決定し，プロトコルのみを論文(プロトコル論文)としてOpen Accessジャーナルへ投稿・発表予定であった．しかし研究協力者が本務多忙につき，論文投稿までには至らなかった．研究期間の半ばを過ぎてもデータ獲得が為されていないこの危機的状況から脱するため，われわれは大きな研究戦略の変更を行った．まず新たな研究戦略の方向性を模索するため，平成29年10月に米国麻酔学会(マサチューセッツ州，ボストン市)へ出張し，いくつかの着想を得た．当初の予定はDNAマイクロアレイで少数のサンプルを用いた疑似ゲノムワイド関連解析を行う予定であったが，過去に取得したデータのインシリコ解析を最初に行うことでゲノム上の対象領域を狭めて遺伝子解析を行う方針とした．しかし，あまり有意な知見は得られなかった．また臨床データ取得のための研究協力者が本務多忙な状況は依然として変わらず，新たに協力者を探したが適任者が見つからなかった．研究期間内(平成31年3月まで)に解析に値する臨床データ，遺伝データを得ることはできないと考え，研究の遂行中止を決断した．そのため科学研究費の補助をこれ以上，受益するわけにはいかないため，日本学術振興会への補助金返上を最後に行った．研究は研究期間内に遂行できなかったが，あらためて研究資金を獲得できれば再開する予定である．

  21. Galpha14-mediated NK1 receptor cell signaling in the celiac-superior mesenteric ganglion

    Yamauchi Masanori, RUIZ-VELASCO Victor, IMAMURA Yuka, ENDO Yasuhiro, MURAKAMI Toru

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

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    Celiac-superior mesenteric ganglion (CSMG) is involved in regulating abdominal organ function, and is also involved in visceral pain transmission. We investigated the modulation of Ca2+ and M-type K+ currents by the tachykinin substance P (SP)/neurokinin-1 receptor signaling pathway in acutely dissociated rat CSMG neurons (with Prof. Ruiz-Velasco at Penn State University). The results of an electrophysiological study showed that SP blocked the Ca2+ and M-currents. Silencing the Gα14 subunit, a member of the Gαq/11 subfamily, significantly attenuated the Ca2+ and M-current blocks. The results suggest that in CSMG neurons, SP-stimulated NK-1 receptors modulate Ca2+ and M-currents by employing a single pathway requiring Gα14 subunits. Moreover, to identify genetic mechanisms in the pathway, we have developed a single-cell whole transcriptome sequencing method using a neuron after electrophysiological recording. We will find changes in the transcriptome of the neurons in near future.

  22. Whole transcriptome analysis of the brain in a shrew model of postoperative nausea and vomiting Competitive

    Sugino Shigekazu, KONNO Daisuke, SUZUKI Jun, MISAWA Kazuharu, SHIBATA Tomoko, KAWAI Yosuke, IMAMURA Yuka, NAGASAKI Masao, KIDO Kanta

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

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    Postoperative nausea and vomiting (PONV) is a serious complication after emergence from general anesthesia. However, the molecular mechanisms underlying PONV have not been fully elucidated. Musk shrews are used for emetic research worldwide because standard laboratory animals, such as rats and mice, are not capable of vomiting. The aims of this study were to determine changes in gene expression in the shrew brainstem and to try to determine the causative genes for PONV. The results of a behavioral study showed that emetic episodes occurred in the PONV model shrews but not in naive shrews. Whole transcriptome sequencing showed that EGR1 gene expression levels in the gonadotropin-releasing hormone signaling pathway were significantly altered in the PONV model. We focused on EGR1 transcription factor as a candidate associated with PONV. The findings suggested that the change in EGR1 gene expression level may be involved in the molecular mechanisms underlying the development of PONV.

  23. Analysis of cytoskeleton related genes in elderly patients

    Yamakage Michiaki, HAYASE TOMO

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Sapporo Medical University

    2013/04/01 - 2016/03/31

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    We investigated whether volatile anesthetics caused postoperative cognitive dysfunction (POCD). In humans, desflurane anesthesia showed a better mini mental examination score than did sevoflurane anesthesia. However, we could not find any genetic polymorphisms associated with cognitive function in humans. To examine the association between general anesthesia and POCD, we investigated whole mRNA expression in mouse hippocampal cells by a transcriptome-wide association study. While expression of the Lhx9 gene was suppressed by exposure to volatile anesthetics in juvenile mice, expression of Lhx9 gene was greatly enhanced by exposure to volatile anesthetics in adult mice. These results suggest that volatile anesthetics affect the differentiation of stem cells in the mouse hippocampus, and the results should be useful for exploring biomarkers of POCD.

  24. Determination of the molecular mechanism of volatile anesthetics using transcriptome analysis in thymo-cortico neurons of mice.

    Yamakage Michiaki, HAYASE TOMO

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Sapporo Medical University

    2012/04/01 - 2016/03/31

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    We performed a transcriptome-wide association study, a total mRNA analysis, in the mouse brain to try to determine the molecular mechanism of volatile anesthetics. We also examined the behavior of mice to confirm the association between inhalation of volatile anesthetics and undesirable side effects such as nausea, vomiting, and cognitive dysfunction. Exposure to volatile anesthetics caused an increase in the expression level of the Rtn4rl2 gene in all mice and an increase in the expression level of the Lhx9 gene in aged mice. These results indicated that inhalation of volatile anesthetics causes neuroinflammation and induces apoptosis in juvenile mice. However, we did not find undesirable side effects of exposure to the volatile anesthetics in any of the mice. The results suggest that the mechanism by which exposure to volatile anesthetics causes nausea or cognitive dysfunction in mice is different from that in humans.

  25. Association of epigenetic modulation in the TACR1 gene with opioid-induced nausea and vomiting

    SUGINO Shigekazu, YAMAKAGE Michiaki, HAYASE Tomo, TACHIBANA Shun-suke, NAWA Yuko, MORIYA Hiroyuki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Sapporo Medical University

    2011 - 2013

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    We hypothesized that regulation of the TACR1 gene is involved in the individual differences in severity of postoperative nausea and vomiting (PONV). We examined CpG methylation of the promoter region of the TACR1 gene, which modulates NK1 receptor expression in both human blood and mouse the brain. The results of the current study showed that the level of methylation was inversely correlated with the intensity of PONV. This new finding may contribute to preoperative prediction of the severity of PONV in surgical patients.

  26. Association of genetic polymorphisms of the GABRB3 gene with the concentration of propofol at loss of consciousness

    NAWA Yuko, SUGINO Shigekazu, HAYASE Tomo, SATO Michiko, TACHIBANA Shun-suke, MORIYA Hiroyuki, YAMAKAGE Michiaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Sapporo Medical University

    2011 - 2012

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    We hypothesized that the genetic polymorphisms in the GABRB3 gene are associated with the individual differences in concentration of propofol at loss of consciousness. We examined the genotypes of single nucleotide polymorphisms (SNPs) in the coding sequence of the GABRB3 gene. However, none of the genotyped SNPs were associated with the concentration at loss of consciousness. These results raised the possibility that we need to change the experimental design or to increase the size of the cohort.

  27. Establishment of Personalized Analgesia for Postoperative Pain

    SUGINO Shigekazu, NAMIKI Akiyoshi, HAYASE Tomo, HIGUCHI Misako, KUMETA Yukihiro, SAITOU Katsuhiko, MORIYA Hiroyuki, KUROSAWA Nahoko

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Sapporo Medical University

    2008 - 2010

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    We studied the individual differences in postoperative pain and opioid sensitivity. We focused on the single nucleotide polymorphisms (SNPs) of oprm1 gene. We showed the associations of opioid-induced emesis with haplotypes of eight SNPs of oprm1 gene. This new finding may contribute to prediction of the occurrence of nausea and vomiting in the preoperative period.

  28. 延髄痛覚受容ニューロン(RVMニューロン)の機能特性への遺伝的影響

    杉野 繁一

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 若手研究(B)

    Category: 若手研究(B)

    Institution: 札幌医科大学

    2006 - 2007

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    本研究では延髄の疼痛伝達における制御中枢であるRVMの機能を行動学的,電気生理学的に詳細に検討した。特に近交系マウスの系統(CBA/JとA/J)間で行動学的研究と電気生理学的研究の機能特性に差があることが示された。さらに注目すべきことに,RVMニューロンのタイプは電気生理学的に3種類存在するが,2系統間で存在する割合に差があることが判明した。さらにmu-opioidレセプタ作動薬であるDAMGOを脳室内投与したが,機能特性の変化に差があることが明らかになった。本研究から疼痛やオピオイドの反応性の個人差を予測するための研究で重要なのは神経ネットワークの機能の遺伝的差異が重要であることが強く示唆された。 今後,本研究結果の機序を分子生物学的に検討するために,mu-opioidレセプタの遺伝子多型をターゲットにして研究を進める予定である。同時に手術患者におけるオピオイド鎮痛の差異と遺伝的差異の関連を検討する予定である。

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Teaching Experience 5

  1. Bed-side Leaning on Anesthesiology: Acute Pain Service　Tohoku University

  2. Elective Bed-side Learning on Anesthesiology: History of Anesthesia Practice　Tohoku University

  3. Elective Bed-side Learning on Anesthesiology: Pre-OP　Tohoku University

  4. Attractive Research on Anesthesiology　Tohoku University

  5. Bed-side Leaning on Anesthesiology: Blood Gas Analysis　Tohoku University