Details of the Researcher

PHOTO

Norio Suzuki
Section
New Industry Creation Hatchery Center
Job title
Professor
Degree

  • 博士（医学）（筑波大学）

  • 修士（医科学）（筑波大学）

Research History 8

  • 2022/01 - Present
    New Industry Creation Hatchery Center, Tohoku University　Applied Oxygen Physiology Project　Professor

  • 2016/04 - 2021/12
    Tohoku University　Graduate School of Medicine　Associate Professor

  • 2012/02 - 2016/03
    Tohoku University　Graduate School of Medicine

  • 2011/01 - 2012/01
    Tohoku University　Graduate School of Medicine　Lecturer

  • 2010/02 - 2011/01
    Karolinska Institute　Senior Research Manager

  • 2008/02 - 2010/01
    Karolinska Institute

  • 2004/04 - 2008/01
    科学技術振興機構 技術参事・研究員・グループリーダー（筑波大学）

  • 2003/04 - 2004/03
    ヒューマンサイエンス振興財団 リサーチレジデント（筑波大学）

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Education 4

  • University of Tsukuba

    - 2003

  • University of Tsukuba　Graduate School, Division of Medicine

    - 2003

  • University of Tsukuba

    - 1997

  • University of Tsukuba　Second Cluster of College

    - 1997

Committee Memberships 1

  • 独立行政法人 科学技術振興機構 遺伝子組換え実験安全委員

    2005/04 - 2007/03

Professional Memberships 2

  • 日本生化学会

  • 日本分子生物学会

Research Interests 5

  • 遺伝子改変マウス

  • erythropoietin

  • Hypoxia response

  • 転写制御

  • Transcriptional regulation

Research Areas 3

  • Life sciences / Medical biochemistry /

  • Life sciences / Developmental biology /

  • Life sciences / Molecular biology /

Papers 112

  1. The drug-specific properties of hypoxia-inducible factor-prolyl hydroxylase inhibitors in mice reveal a significant contribution of the kidney compared to the liver to erythropoietin induction

    Taku Nakai, Daisuke Saigusa, Koichiro Kato, Tomoko Fukuuchi, Seizo Koshiba, Masayuki Yamamoto, Norio Suzuki

    Life Sciences　346　122641-122641　2024/06

    Publisher: Elsevier BV

    DOI： 10.1016/j.lfs.2024.122641 　

    ISSN： 0024-3205

  2. PNPO–PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity

    Hiroki Sekine, Haruna Takeda, Norihiko Takeda, Akihiro Kishino, Hayato Anzawa, Takayuki Isagawa, Nao Ohta, Shohei Murakami, Hideya Iwaki, Nobufumi Kato, Shu Kimura, Zun Liu, Koichiro Kato, Fumiki Katsuoka, Masayuki Yamamoto, Fumihito Miura, Takashi Ito, Masatomo Takahashi, Yoshihiro Izumi, Hiroyuki Fujita, Hitoshi Yamagata, Takeshi Bamba, Takaaki Akaike, Norio Suzuki, Kengo Kinoshita, Hozumi Motohashi

    Nature Metabolism　2024/05/31

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s42255-024-01053-4 　

    eISSN： 2522-5812

  3. Crosstalk between oxygen signaling and iron metabolism in renal interstitial fibroblasts.

    Norio Suzuki, Yuma Iwamura, Koichiro Kato, Hirotaka Ishioka, Yusuke Konta, Koji Sato, Nao Uchida, Noa Koida, Hiroki Sekine, Tetsuhiro Tanaka, Naonori Kumagai, Taku Nakai

    Journal of clinical biochemistry and nutrition　74　(3)　179-184　2024/05

    DOI： 10.3164/jcbn.24-8 　

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    To maintain the oxygen supply, the production of red blood cells (erythrocytes) is promoted under low-oxygen conditions (hypoxia). Oxygen is carried by hemoglobin in erythrocytes, in which the majority of the essential element iron in the body is contained. Because iron metabolism is strictly controlled in a semi-closed recycling system to protect cells from oxidative stress caused by iron, hypoxia-inducible erythropoiesis is closely coordinated by regulatory systems that mobilize stored iron for hemoglobin synthesis. The erythroid growth factor erythropoietin (EPO) is mainly secreted by interstitial fibroblasts in the renal cortex, which are known as renal EPO-producing (REP) cells, and promotes erythropoiesis and iron mobilization. Intriguingly, EPO production is strongly induced by hypoxia through iron-dependent pathways in REP cells. Here, we summarize recent studies on the network mechanisms linking hypoxia-inducible EPO production, erythropoiesis and iron metabolism. Additionally, we introduce disease mechanisms related to disorders in the network mediated by REP cell functions. Furthermore, we propose future studies regarding the application of renal cells derived from the urine of kidney disease patients to investigate the molecular pathology of chronic kidney disease and develop precise and personalized medicine for kidney disease.

  4. Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice Peer-reviewed

    Shimizu R, Hirano I, Hasegawa A, Suzuki M, Otsuki A, Taguchi K, Katsuoka F, Uruno A, Suzuki N, Yumoto A, Okada R, Shrakawa M, Shiba D, Takahashi S, Suzuki T, Yamamoto M

    Commun Biol　6　2023/08

    DOI： 10.1038/s42003-022-03316-w 　

  5. Drugs activating hypoxia-inducible factors correct erythropoiesis and hepcidin levels via renal EPO induction in mice. International-journal

    Taku Nakai, Yuma Iwamura, Koichiro Kato, Ikuo Hirano, Yotaro Matsumoto, Yoshihisa Tomioka, Masayuki Yamamoto, Norio Suzuki

    Blood advances　2023/05/05

    DOI： 10.1182/bloodadvances.2023009798 　

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    The erythroid growth factor erythropoietin (EPO) is mainly produced by the kidneys in adult mammals and induces expansion of erythroid cells and iron use for hemoglobin synthesis. The liver also produces EPO at a lower level than the kidneys. Renal and hepatic EPO production is fundamentally regulated by hypoxia-inducible transcription factors (HIFs) in a hypoxia/anemia-inducible manner. Recently, small compounds that activate HIFs and EPO production in the kidneys by inhibiting HIF-prolyl hydroxylases (HIF-PHIs) have been launched to treat EPO-deficiency anemia in patients suffering from kidney disease. However, the roles of the liver in the HIF-PHI-mediated induction of erythropoiesis and iron mobilization remain controversial. Here, to elucidate the liver contributions to the therapeutic effects of HIF-PHIs, genetically modified mouse lines lacking renal EPO-production ability were analyzed. In the mutant mice, HIF-PHI administration marginally increased plasma EPO concentrations and peripheral erythrocytes by inducing hepatic EPO production. The effects of HIF-PHIs on the mobilization of stored iron and on the suppression of hepatic hepcidin, an inhibitory molecule for iron release from iron-storage cells, were not observed in the mutant mice. These findings demonstrate that adequate induction of EPO mainly in the kidney is essential for achieving the full therapeutic effects of HIF-PHIs, which include hepcidin suppression. The data also show that HIF-PHIs directly induce the expression of duodenal genes related to dietary iron intake. Additionally, hepatic EPO induction is considered to partially contribute to the erythropoietic effects of HIF-PHIs but to be insufficient to compensate for the abundant EPO induction by the kidneys.

  6. Correction to "Prolyl Hydroxylase Domain Protein Inhibitor Not Harboring a 2-Oxoglutarate Scaffold Protects against Hypoxic Stress". International-journal

    Kento Sonoda, Sudarma Bogahawaththa, Akito Katayama, Saki Ujike, Sae Kuroki, Naho Kitagawa, Kohichi Hirotsuru, Norio Suzuki, Toshio Miyata, Shin-Ichi Kawaguchi, Tadayuki Tsujita

    ACS pharmacology & translational science　5　(7)　512-512　2022/07/08

    DOI： 10.1021/acsptsci.2c00094 　

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    [This corrects the article DOI: 10.1021/acsptsci.2c00002.].

  7. Prolyl Hydroxylase Domain Protein Inhibitor Not Harboring a 2-Oxoglutarate Scaffold Protects against Hypoxic Stress. International-journal

    Kento Sonoda, Sudarma Bogahawatta, Akito Katayama, Saki Ujike, Sae Kuroki, Naho Kitagawa, Kohichi Hirotsuru, Norio Suzuki, Toshio Miyata, Shin-Ichi Kawaguchi, Tadayuki Tsujita

    ACS pharmacology & translational science　5　(5)　362-372　2022/05/13

    DOI： 10.1021/acsptsci.2c00002 　

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    Hypoxia-inducible factor-α (HIF-α) activation has shown promising results in the treatment of ischemia, such as stroke, myocardial infarction, and chronic kidney disease. A number of HIF-α activators have been developed to improve the symptoms of these diseases. Many feature 2-oxoglutarate (2-OG) scaffolds that interact with the active centers of prolyl hydroxylase domain-containing proteins (PHDs), displacing the coenzyme 2-OG. This stabilizes HIF-α. Therefore, the specificity of the 2-OG analogs is not high. Here, we identified 5-(1-acetyl-5-phenylpyrazolidin-3-ylidene)-1,3-dimethylbarbituric acid (PyrzA) among over 10 000 compounds as a novel HIF activator that does not contain a 2-OG scaffold. In cultured cells, PyrzA enhanced HIF-α stability and upregulated the expression of HIF target genes. Interestingly, PyrzA decreased HIF-1α prolyl hydroxylation, suggesting that PyrzA may activate HIF to prevent the degradation of HIF-α. These results indicate that PyrzA stabilizes HIF via a novel mechanism and could be a potential HIF activator candidate.

  8. Esterification promotes the intracellular accumulation of roxadustat, an activator of hypoxia-inducible factors, to extend its effective duration. International-journal

    Taku Nakai, Daisuke Saigusa, Yuma Iwamura, Yotaro Matsumoto, Keiko Umeda, Koichiro Kato, Hayato Yamaki, Yoshihisa Tomioka, Ikuo Hirano, Seizo Koshiba, Masayuki Yamamoto, Norio Suzuki

    Biochemical pharmacology　197　114939-114939　2022/03

    DOI： 10.1016/j.bcp.2022.114939 　

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    Kidney injury often causes anemia due to a lack of production of the erythroid growth factor erythropoietin (EPO) in the kidneys. Roxadustat is one of the first oral medicines inducing EPO production in patients with renal anemia by activating hypoxia-inducible factors (HIFs), which are activators of EPO gene expression. In this study, to develop prodrugs of roxadustat with improved permeability through cell membrane, we investigated the effects of 8 types of esterification on the pharmacokinetics and bioactivity of roxadustat using Hep3B hepatoma cells that HIF-dependently produce EPO. Mass spectrometry of cells incubated with the esterified roxadustat derivatives revealed that the designed compounds were deesterified after being taken up by cells and showed low cytotoxicity compared to the original compound. Esterification prolonged the effective duration of roxadustat with respect to EPO gene induction and HIF activation in cells transiently exposed to the compounds. In the kidneys and livers of mice, both of which are unique sites of EPO production, a majority of the methyl-esterified roxadustat was deesterified within 6 h after drug administration. The deesterified roxadustat derivative was continuously detectable in plasma and urine for at least 48 h after administration, while the administered compound became undetectable 24 h after administration. Additionally, we confirmed that methyl-esterified roxadustat activated erythropoiesis in mice by inducing Epo mRNA expression exclusively in renal interstitial cells, which have intrinsic EPO-producing potential. These data suggest that esterification could lead to the development of roxadustat prodrugs with improvements in cell membrane permeability, effective duration and cytotoxicity.

  9. Gene expression changes related to bone mineralization, blood pressure and lipid metabolism in mouse kidneys after space travel. International-journal

    Norio Suzuki, Yuma Iwamura, Taku Nakai, Koichiro Kato, Akihito Otsuki, Akira Uruno, Daisuke Saigusa, Keiko Taguchi, Mikiko Suzuki, Ritsuko Shimizu, Akane Yumoto, Risa Okada, Masaki Shirakawa, Dai Shiba, Satoru Takahashi, Takafumi Suzuki, Masayuki Yamamoto

    Kidney international　101　(1)　92-105　2022/01

    DOI： 10.1016/j.kint.2021.09.031 　

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    Space travel burdens health by imposing considerable environmental stress associated with radioactivity and microgravity. In particular, gravity change predominantly impacts blood pressure and bone homeostasis, both of which are controlled mainly by the kidneys. Nuclear factor erythroid-2-related transcription factor 2 (Nrf2) plays essential roles in protecting the kidneys from various environmental stresses and injuries. To elucidate the effects of space travel on mammals in preparation for the upcoming space era, our study investigated the contribution of Nrf2 to kidney function in mice two days after their return from a 31-day stay in the International Space Station using Nrf2 knockout mice. Meaningfully, expression levels of genes regulating bone mineralization, blood pressure and lipid metabolism were found to be significantly altered in the kidneys after space travel in an Nrf2-independent manner. In particular, uridine diphosphate-glucuronosyltransferase 1A (Ugt1a) isoform genes were found to be expressed in an Nrf2-dependent manner and induced exclusively in the kidneys after return to Earth. Since spaceflight elevated the concentrations of fatty acids in the mouse plasma, we suggest that Ugt1a isoform expression in the kidneys was induced to promote glucuronidation of excessively accumulated lipids and excrete them into urine after the return from space. Thus, the kidneys were proven to play central roles in adaptation to gravity changes caused by going to and returning from space by controlling blood pressure and bone mineralization. Additionally, kidney Ugt1a isoform induction after space travel implies a significant role of the kidneys for space travelers in the excretion of excessive lipids.

  10. Efficient isolation of interstitial fibroblasts directly from mouse kidneys or indirectly after ex vivo expansion. International-journal

    Taku Nakai, Yuma Iwamura, Norio Suzuki

    STAR protocols　2　(4)　100826-100826　2021/12/17

    DOI： 10.1016/j.xpro.2021.100826 　

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    Renal interstitial fibroblasts are responsible for producing the erythroid growth factor Epo and the vasopressor renin in addition to kidney fibrosis, in which they are transformed into myofibroblasts. Therefore, analyses of fibroblasts may elucidate the complex mechanisms of kidney diseases. However, the fragility of these cells makes their isolation for in vitro analyses and ex vivo cultivation difficult. We have overcome these difficulties by mildly dissociating mouse kidneys and coculturing fibroblasts with other kidney cells in semisolid medium. For complete details on the use and execution of this protocol, please refer to Sato et al. (2019a) and Miyauchi et al. (2021).

  11. Osteoclasts adapt to physioxia perturbation through DNA demethylation. International-journal

    Keizo Nishikawa, Shigeto Seno, Toshitada Yoshihara, Ayako Narazaki, Yuki Sugiura, Reito Shimizu, Junichi Kikuta, Reiko Sakaguchi, Norio Suzuki, Norihiko Takeda, Hiroaki Semba, Masamichi Yamamoto, Daisuke Okuzaki, Daisuke Motooka, Yasuhiro Kobayashi, Makoto Suematsu, Haruhiko Koseki, Hideo Matsuda, Masayuki Yamamoto, Seiji Tobita, Yasuo Mori, Masaru Ishii

    EMBO reports　22　(12)　e53035　2021/12/06

    DOI： 10.15252/embr.202153035 　

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    Oxygen plays an important role in diverse biological processes. However, since quantitation of the partial pressure of cellular oxygen in vivo is challenging, the extent of oxygen perturbation in situ and its cellular response remains underexplored. Using two-photon phosphorescence lifetime imaging microscopy, we determine the physiological range of oxygen tension in osteoclasts of live mice. We find that oxygen tension ranges from 17.4 to 36.4 mmHg, under hypoxic and normoxic conditions, respectively. Physiological normoxia thus corresponds to 5% and hypoxia to 2% oxygen in osteoclasts. Hypoxia in this range severely limits osteoclastogenesis, independent of energy metabolism and hypoxia-inducible factor activity. We observe that hypoxia decreases ten-eleven translocation (TET) activity. Tet2/3 cooperatively induces Prdm1 expression via oxygen-dependent DNA demethylation, which in turn activates NFATc1 required for osteoclastogenesis. Taken together, our results reveal that TET enzymes, acting as functional oxygen sensors, regulate osteoclastogenesis within the physiological range of oxygen tension, thus opening new avenues for research on in vivo response to oxygen perturbation.

  12. Nrf2 plays a critical role in the metabolic response during and after spaceflight

    Akira Uruno, Daisuke Saigusa, Takafumi Suzuki, Akane Yumoto, Tomohiro Nakamura, Naomi Matsukawa, Takahiro Yamazaki, Ristumi Saito, Keiko Taguchi, Mikiko Suzuki, Norio Suzuki, Akihito Otsuki, Fumiki Katsuoka, Eiji Hishinuma, Risa Okada, Seizo Koshiba, Yoshihisa Tomioka, Ritsuko Shimizu, Masaki Shirakawa, Thomas W. Kensler, Dai Shiba, Masayuki Yamamoto

    Communications Biology　4　(1)　2021/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s42003-021-02904-6 　

    eISSN： 2399-3642

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    <title>Abstract</title>Space travel induces stresses that contribute to health problems, as well as inducing the expression of Nrf2 (NF-E2-related factor-2) target genes that mediate adaptive responses to oxidative and other stress responses. The volume of epididymal white adipose tissue (eWAT) in mice increases during spaceflight, a change that is attenuated by <italic>Nrf2</italic> knockout. We conducted metabolome analyses of plasma from wild-type and <italic>Nrf2</italic> knockout mice collected at pre-flight, in-flight and post-flight time points, as well as tissues collected post-flight to clarify the metabolic responses during and after spaceflight and the contribution of Nrf2 to these responses. Plasma glycerophospholipid and sphingolipid levels were elevated during spaceflight, whereas triacylglycerol levels were lower after spaceflight. In wild-type mouse eWAT, triacylglycerol levels were increased, but phosphatidylcholine levels were decreased, and these changes were attenuated in <italic>Nrf2</italic> knockout mice. Transcriptome analyses revealed marked changes in the expression of lipid-related genes in the liver and eWAT after spaceflight and the effects of <italic>Nrf2</italic> knockout on these changes. Based on these results, we concluded that space stress provokes significant responses in lipid metabolism during and after spaceflight; Nrf2 plays critical roles in these responses.

  13. Distinct Regulations of HO-1 Gene Expression for Stress Response and Substrate Induction. International-journal

    Anqi Zhang, Takafumi Suzuki, Saki Adachi, Eriko Naganuma, Norio Suzuki, Tomonori Hosoya, Ken Itoh, Michael B Sporn, Masayuki Yamamoto

    Molecular and cellular biology　41　(11)　e0023621　2021/10/26

    DOI： 10.1128/MCB.00236-21 　

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    Heme oxygenase 1 (HO-1) is the key enzyme for heme catabolism and cytoprotection. Whereas HO-1 gene expression in response to various stresses has been investigated extensively, the precise mechanisms by which HO-1 gene expression is regulated by the HO-1 substrate heme remain elusive. To systematically examine whether stress-mediated induction and substrate-mediated induction of HO-1 utilize similar or distinct regulatory pathways, we developed an HO-1-DsRed-knock-in reporter mouse in which the HO-1 gene is floxed by loxP sites and the DsRed gene has been inserted. Myeloid lineage-specific recombination of the floxed locus led to fluorescence derived from expression of the HO-1-DsRed fusion protein in peritoneal macrophages. We also challenged general recombination of the locus and generated mice harboring heterozygous recombinant alleles, which enabled us to monitor HO-1-DsRed expression in the whole body in vivo and ex vivo. HO-1 inducers upregulated HO-1-DsRed expression in myeloid lineage cells isolated from the mice. Notably, analyses of peritoneal macrophages from HO-1-DsRed mice lacking NRF2, a major regulator of the oxidative/electrophilic stress response, led us to identify NRF2-dependent stress response-mediated HO-1 induction and NRF2-independent substrate-mediated HO-1 induction. Thus, the HO-1 gene is subjected to at least two distinct levels of regulation, and the available lines of evidence suggest that substrate induction in peritoneal macrophages is independent of CNC family-based regulation.

  14. Renal NG2-expressing cells have a macrophage-like phenotype and facilitate renal recovery after ischemic injury. International-journal

    Wararat Kittikulsuth, Daisuke Nakano, Kento Kitada, Norio Suzuki, Masayuki Yamamoto, Akira Nishiyama

    American journal of physiology. Renal physiology　321　(2)　F170-F178　2021/08/01

    DOI： 10.1152/ajprenal.00011.2021 　

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    Pericytes play an important role in the recovery process after ischemic injury of many tissues. Brain pericytes in the peri-infarct area express macrophage markers in response to injury stimuli and are involved in neovascularization. In the kidney, nerve/glial antigen 2 (NG2)+ pericytes have been found to accumulate after renal injury. These accumulated NG2+ cells are not involved in scar formation. However, the role of accumulated NG2+ cells in injured kidneys remains unknown. Here, using a reversible ischemia-reperfusion (I/R) model, we found that renal NG2+ cells were increased in injured kidneys and expressed macrophage markers (CD11b or F4/80) on day 3 after reperfusion. Isolated NG2+ cells from I/R kidneys also had phagocytic activity and expressed anti-inflammatory cytokine genes, including mannose receptor and IL-10. These macrophage-like NG2+ cells did not likely differentiate into myofibroblasts because they did not increase α-smooth muscle actin expression. Intravenous transfusion of renal NG2+ cells isolated from donor mice on day 3 after reperfusion into recipient mice on day 1 after I/R surgery revealed that NG2+ cell-injected mice had lower plasma blood urea nitrogen, reduced kidney injury molecule-1 mRNA expression, ameliorated renal damage, and reduced cellular debris accumulation compared with PBS-injected mice on day 5 after reperfusion. In conclusion, these data suggest that renal NG2+ cells have an M2 macrophage-like ability and play a novel role in facilitating the recovery process after renal I/R injury.NEW & NOTEWORTHY Brain pericytes have macrophage-like activities after injury. However, such properties of pericytes in peripheral tissues have not been investigated. Here, we provide evidence that nerve/glial antigen 2-positive cells increase after renal injury. The population of nerve/glial antigen 2-positive cells, which does not increase expression of myofibroblast-associated gene, express macrophage markers and anti-inflammatory cytokine genes, have phagocytic activity, and play a role in renal recovery after kidney injury.

  15. Defining the functionally sufficient regulatory region and liver-specific roles of the erythropoietin gene by transgene complementation

    Shun Yamazaki, Ikuo Hirano, Koichiro Kato, Masayuki Yamamoto, Norio Suzuki

    Life Sciences　269　2021/03/15

    DOI： 10.1016/j.lfs.2021.119075 　

    ISSN： 0024-3205

    eISSN： 1879-0631

  16. Renal interstitial fibroblasts coproduce erythropoietin and renin under anaemic conditions

    Kenichiro Miyauchi, Taku Nakai, Sakae Saito, Tae Yamamoto, Koji Sato, Koichiro Kato, Masahiro Nezu, Mariko Miyazaki, Sadayoshi Ito, Masayuki Yamamoto, Norio Suzuki

    EBioMedicine　64　2021/02

    DOI： 10.1016/j.ebiom.2021.103209 　

    eISSN： 2352-3964

  17. Nrf2 activation for kidney disease treatment—a mixed blessing?

    Masahiro Nezu, Norio Suzuki

    Kidney International　99　(1)　20-22　2021/01

    DOI： 10.1016/j.kint.2020.08.033 　

    ISSN： 0085-2538

    eISSN： 1523-1755

  18. Nrf2 contributes to the weight gain of mice during space travel

    Takafumi Suzuki, Akira Uruno, Akane Yumoto, Keiko Taguchi, Mikiko Suzuki, Nobuhiko Harada, Rie Ryoke, Eriko Naganuma, Nanae Osanai, Aya Goto, Hiromi Suda, Ryan Browne, Akihito Otsuki, Fumiki Katsuoka, Michael Zorzi, Takahiro Yamazaki, Daisuke Saigusa, Seizo Koshiba, Takashi Nakamura, Satoshi Fukumoto, Hironobu Ikehata, Keizo Nishikawa, Norio Suzuki, Ikuo Hirano, Ritsuko Shimizu, Tetsuya Oishi, Hozumi Motohashi, Hirona Tsubouchi, Risa Okada, Takashi Kudo, Michihiko Shimomura, Thomas W. Kensler, Hiroyasu Mizuno, Masaki Shirakawa, Satoru Takahashi, Dai Shiba, Masayuki Yamamoto

    Communications Biology　3　(1)　2020/12/01

    DOI： 10.1038/s42003-020-01227-2 　

    eISSN： 2399-3642

  19. Effects of post-renal anemia treatment with the HIF-PHD inhibitor molidustat on adenine-induced renal anemia and kidney disease in mice

    Lei Li, Daisuke Nakano, Anqi Zhang, Wararat Kittikulsuth, Norihiko Morisawa, Hiroyuki Ohsaki, Norio Suzuki, Masayuki Yamamoto, Akira Nishiyama

    Journal of Pharmacological Sciences　144　(4)　229-236　2020/12

    DOI： 10.1016/j.jphs.2020.09.004 　

    ISSN： 1347-8613

    eISSN： 1347-8648

  20. Erratum: Author Correction: Nrf2 contributes to the weight gain of mice during space travel (Communications biology (2020) 3 1 (496))

    Takafumi Suzuki, Akira Uruno, Akane Yumoto, Keiko Taguchi, Mikiko Suzuki, Nobuhiko Harada, Rie Ryoke, Eriko Naganuma, Nanae Osanai, Aya Goto, Hiromi Suda, Ryan Browne, Akihito Otsuki, Fumiki Katsuoka, Michael Zorzi, Takahiro Yamazaki, Daisuke Saigusa, Seizo Koshiba, Takashi Nakamura, Satoshi Fukumoto, Hironobu Ikehata, Keizo Nishikawa, Norio Suzuki, Ikuo Hirano, Ritsuko Shimizu, Tetsuya Oishi, Hozumi Motohashi, Hirona Tsubouchi, Risa Okada, Takashi Kudo, Michihiko Shimomura, Thomas W. Kensler, Hiroyasu Mizuno, Masaki Shirakawa, Satoru Takahashi, Dai Shiba, Masayuki Yamamoto

    Communications biology　3　(1)　566　2020/10/07

    DOI： 10.1038/s42003-020-01292-7 　

    eISSN： 2399-3642

  21. Roles of NRF2 in protecting the kidney from oxidative damage Peer-reviewed

    Masahiro Nezu, Norio Suzuki

    International Journal of Molecular Sciences　21　(8)　2020/04

    DOI： 10.3390/ijms21082951 　

    ISSN： 1661-6596

    eISSN： 1422-0067

  22. Alteration of the DNA Methylation Signature of Renal Erythropoietin-Producing Cells Governs the Sensitivity to Drugs Targeting the Hypoxia-Response Pathway in Kidney Disease Progression Peer-reviewed

    Koji Sato, Naonori Kumagai, Norio Suzuki

    Frontiers in Genetics　10　2019/11/13

    DOI： 10.3389/fgene.2019.01134 　

    eISSN： 1664-8021

  23. An immortalized cell line derived from renal erythropoietin-producing (REP) cells demonstrates their potential to transform into myofibroblasts. International-journal Peer-reviewed

    Koji Sato, Ikuo Hirano, Hiroki Sekine, Kenichiro Miyauchi, Taku Nakai, Koichiro Kato, Sadayoshi Ito, Masayuki Yamamoto, Norio Suzuki

    Scientific reports　9　(1)　11254-11254　2019/08/02

    DOI： 10.1038/s41598-019-47766-5 　

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    The erythroid growth factor erythropoietin (Epo) is produced by renal interstitial fibroblasts, called REP (renal Epo-producing) cells, in a hypoxia-inducible manner. In chronic kidney disease (CKD), REP cells lose their Epo-production ability, leading to renal anaemia. Concurrently, REP cells are suggested to be transformed into myofibroblasts, which are the major player of renal fibrosis. Although establishment of cultured cell lines derived from REP cells has been a long-term challenge, we here successfully established a REP-cell-derived immortalized and cultivable cell line (Replic cells) by using a genetically modified mouse line. Replic cells exhibited myofibroblastic phenotypes and lost their Epo-production ability, reflecting the situation in renal fibrosis. Additionally, we found that cell-autonomous TGFβ signalling contributes to maintenance of the myofibroblastic features of Replic cells. Furthermore, the promoters of genes for Epo and HIF2α, a major activator of Epo gene expression, were highly methylated in Replic cells. Thus, these results strongly support our contention that REP cells are the origin of myofibroblasts in fibrotic kidneys and demonstrate that cell-autonomous TGFβ signalling and epigenetic silencing are involved in renal fibrosis and renal anaemia, respectively, in CKD. The Replic cell line is a useful tool to further investigate the molecular mechanisms underlying renal fibrosis.

  24. The Neural Crest as the First Production Site of the Erythroid Growth Factor Erythropoietin. Peer-reviewed

    Hirano I, Suzuki N

    Frontiers in cell and developmental biology　7　105　2019

    DOI： 10.3389/fcell.2019.00105 　

  25. O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF1. International-journal Peer-reviewed

    Hiroki Sekine, Keito Okazaki, Koichiro Kato, M Morshedul Alam, Hiroki Shima, Fumiki Katsuoka, Tadayuki Tsujita, Norio Suzuki, Akira Kobayashi, Kazuhiko Igarashi, Masayuki Yamamoto, Hozumi Motohashi

    Molecular and cellular biology　38　(17)　2018/09/01

    DOI： 10.1128/MCB.00252-18 　

    ISSN： 0270-7306

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    Cancer cells often heavily depend on the ubiquitin-proteasome system (UPS) for their growth and survival. Irrespective of their strong dependence on the proteasome activity, cancer cells, except for multiple myeloma, are mostly resistant to proteasome inhibitors. A major cause of this resistance is the proteasome bounce-back response mediated by NRF1, a transcription factor that coordinately activates proteasome subunit genes. To identify new targets for efficient suppression of UPS, we explored, using immunoprecipitation and mass spectrometry, the possible existence of nuclear proteins that cooperate with NRF1 and identified O-linked N-acetylglucosamine transferase (OGT) and host cell factor C1 (HCF-1) as two proteins capable of forming a complex with NRF1. O-GlcNAcylation catalyzed by OGT was essential for NRF1 stabilization and consequent upregulation of proteasome subunit genes. Meta-analysis of breast and colorectal cancers revealed positive correlations in the relative protein abundance of OGT and proteasome subunits. OGT inhibition was effective at sensitizing cancer cells to a proteasome inhibitor both in culture cells and a xenograft mouse model. Since active O-GlcNAcylation is a feature of cancer metabolism, our study has clarified a novel linkage between cancer metabolism and UPS function and added a new regulatory axis to the regulation of the proteasome activity.

  26. Iron attenuates erythropoietin production by decreasing hypoxia-inducible transcription factor 2α concentrations in renal interstitial fibroblasts. Peer-reviewed

    Suzuki N, Matsuo-Tezuka Y, Sasaki Y, Sato K, Miyauchi K, Kato K, Saito S, Shimonaka Y, Hirata M, Yamamoto M

    Kidney international　94　(5)　900-911　2018/09

    Publisher: Elsevier BV

    DOI： 10.1016/j.kint.2018.06.028 　

    ISSN： 0085-2538

  27. 【ホルモンと腎泌尿器系疾患update】腎障害によるエリスロポエチン産生低下の分子機構 Peer-reviewed

    宮内 健一郎, 鈴木 教郎

    腎臓内科・泌尿器科　8　(2)　103-107　2018/08

    Publisher: (有)科学評論社

    ISSN： 2188-9147

  28. 【赤血球造血のメカニズムとその異常 -最近の進歩-】エリスロポエチンによる赤血球造血制御のメカニズム Peer-reviewed

    鈴木 教郎

    血液フロンティア　28　(9)　1301-1308　2018/08

    Publisher: (株)医薬ジャーナル社

    ISSN： 1344-6940

  29. Erratum: Detection of novel metabolite for roxadustat doping by global metabolomics (Journal of Biochemistry (2018) DOI: 10.1093/jb/mvy028) Peer-reviewed

    Daisuke Saigusa, Norio Suzuki, Yotaro Matsumoto, Keiko Umeda, Yoshihisa Tomioka, Seizo Koshiba, Masayuki Yamamoto

    Journal of Biochemistry　163　(6)　e1　2018/06/01

    Publisher: Oxford University Press

    DOI： 10.1093/jb/mvy036 　

    ISSN： 1756-2651 0021-924X

  30. HIF-dependent and reversible nucleosome disassembly in hypoxia-inducible gene promoters Peer-reviewed

    Norio Suzuki, Nikola Vojnovic, Kian Leong Lee, Henry Yang, Katarina Gradin, Lorenz Poellinger

    Experimental Cell Research　366　(2)　181-191　2018/05/15

    DOI： 10.1016/j.yexcr.2018.03.020 　

    ISSN： 0014-4827

    eISSN： 1090-2422

  31. Detection of novel metabolite for Roxadustat doping by global metabolomics. International-journal Peer-reviewed

    Saigusa D, Suzuki N, Matsumoto Y, Umeda K, Tomioka Y, Koshiba S, Yamamoto M

    Journal of biochemistry　2018/02

    DOI： 10.1093/jb/mvy028 　

    ISSN： 0021-924X

    More details Close

    Roxadustat (FG-4592, Rox) is a stabilizer for hypoxia-inducible transcription factors (HIFs), which induce production of the erythroid growth factor erythropoietin, and has been listed by the World Anti-Doping Agency as a prohibited substance for athletes since 2011. Although the detection technologies for Rox and its glucuronide-conjugated metabolite (Rox-Gluc) have been developed exploiting triple quadrupole mass spectrometry (MS/MS), the production of metabolites from Rox in the human body remains to be clarified. Here, we established a protocol for the detection of unknown metabolites in plasma and urine samples from Rox-doping mice by global metabolomics using an ultra high-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UHPLC-QTOF/MS). We identified methylated Rox (Rox-Methyl), a novel metabolite, and Rox-Gluc in mouse urine by principal component analysis and orthogonal partial least squares discriminant analysis based on detected features by UHPLC-QTOF/MS analysis. The estimated pharmacokinetic parameters of Rox-Methyl and Rox-Gluc in mouse plasma showed similar profiles to that of Rox and both compounds showed similar biological activities. Of note, Rox-Methyl showed shorter half-life than Rox-Gluc in vivo, implying the easy escape from anti-doping screen. These results demonstrate that the global metabolomics method introduced in this study will contribute to the identification and detection of HIF-analog doping.

  32. Palmitate deranges erythropoietin production via transcription factor ATF4 activation of unfolded protein response Peer-reviewed

    Thitinun Anusornvongchai, Masaomi Nangaku, Tzu-Ming Jao, Chia-Hsien Wu, Yu Ishimoto, Hiroshi Maekawa, Tetsuhiro Tanaka, Akira Shimizu, Masayuki Yamamoto, Norio Suzuki, Ryoji Sassa, Reiko Inagi

    Kidney International　94　(3)　536-550　2018

    DOI： 10.1016/j.kint.2018.03.011 　

    ISSN： 1523-1755 0085-2538

  33. Regulation of hypoxia-inducible gene expression after HIF activation Peer-reviewed

    Norio Suzuki, Katarina Gradin, Lorenz Poellinger, Masayuki Yamamoto

    Experimental Cell Research　356　(2)　182-186　2017/07/15

    DOI： 10.1016/j.yexcr.2017.03.013 　

    ISSN： 0014-4827

    eISSN： 1090-2422

  34. Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression Peer-reviewed

    Masahiro Nezu, Norio Suzuki, Masayuki Yamamoto

    American Journal of Nephrology　45　(6)　473-483　2017/06/01

    DOI： 10.1159/000475890 　

    ISSN： 0250-8095

    eISSN： 1421-9670

  35. Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes. International-journal Peer-reviewed

    Masahiro Nezu, Tomokazu Souma, Lei Yu, Hiroki Sekine, Nobuyuki Takahashi, Andrew Zu-Sern Wei, Sadayoshi Ito, Akiyoshi Fukamizu, Zsuzsanna K Zsengeller, Tomohiro Nakamura, Atsushi Hozawa, S Ananth Karumanchi, Norio Suzuki, Masayuki Yamamoto

    Science signaling　10　(479)　2017/05/16

    DOI： 10.1126/scisignal.aam5711 　

    ISSN： 1945-0877

    More details Close

    Placental activation of the renin-angiotensin system (RAS) plays a key role in the pathogenesis of preeclampsia. Reactive oxygen species (ROS) are thought to affect placental angiogenesis, which is critical for preventing preeclampsia pathology. We examined the role of ROS in preeclampsia by genetically modifying the Keap1-Nrf2 pathway, a cellular antioxidant defense system, in a mouse model of RAS-induced preeclampsia. Nrf2 deficiency would be expected to impair cellular antioxidant responses; however, Nrf2 deficiency in preeclamptic mice improved maternal and fetal survival, ameliorated intra-uterine growth retardation, and augmented oxidative DNA damage. Furthermore, the placentas of Nrf2-deficient mice had increased endothelial cell proliferation with dense vascular networks. In contrast, the placentas of preeclamptic mice with overactive Nrf2 showed repressed angiogenesis, which was associated with decreased expression of genes encoding angiogenic chemokines and cytokines. Our findings support the notion that ROS-mediated signaling is essential for maintaining placental angiogenesis in preeclampsia and may provide mechanistic insight into the negative results of clinical trials for antioxidants in preeclampsia.

  36. Renal Anemia Model Mouse Established by Transgenic Rescue with an Erythropoietin Gene Lacking Kidney-Specific Regulatory Elements. International-journal Peer-reviewed

    Ikuo Hirano, Norio Suzuki, Shun Yamazaki, Hiroki Sekine, Naoko Minegishi, Ritsuko Shimizu, Masayuki Yamamoto

    Molecular and cellular biology　37　(4)　2017/02/15

    DOI： 10.1128/MCB.00451-16 　

    ISSN： 0270-7306

  37. Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression Peer-reviewed

    Masahiro Nezu, Tomokazu Souma, Lei Yu, Takafumi Suzuki, Daisuke Saigusa, Sadayoshi Ito, Norio Suzuki, Masayuki Yamamoto

    KIDNEY INTERNATIONAL　91　(2)　387-401　2017/02

    DOI： 10.1016/j.kint.2016.08.023 　

    ISSN： 0085-2538

    eISSN： 1523-1755

  38. NRF2 DEFICIENCY ALLEVIATES PERINATAL COMPLICATIONS IN PREGNANCY-ASSOCIATED HYPERTENSION MICE VIA ENHANCING PLACENTAL ANGIOGENESIS Peer-reviewed

    Nezu Masahiro, Souma Tomokazu, Yu Lei, Sekine Hiroki, Moriguchi Takashi, Takahashi Nobuyuki, Ito Sadayoshi, Suzuki Norio, Yamamoto Masayuki

    JOURNAL OF HYPERTENSION　34　E59　2016/09

    DOI： 10.1097/01.hjh.0000500005.64305.c1 　

    ISSN： 0263-6352

  39. Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling. International-journal Peer-reviewed

    Tomokazu Souma, Masahiro Nezu, Daisuke Nakano, Shun Yamazaki, Ikuo Hirano, Hiroki Sekine, Takashi Dan, Kotaro Takeda, Guo-Hua Fong, Akira Nishiyama, Sadayoshi Ito, Toshio Miyata, Masayuki Yamamoto, Norio Suzuki

    Journal of the American Society of Nephrology : JASN　27　(2)　428-38　2016/02

    DOI： 10.1681/ASN.2014121184 　

    ISSN： 1046-6673

  40. The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression. International-journal Peer-reviewed

    Hiroki Sekine, Keito Okazaki, Nao Ota, Hiroki Shima, Yasutake Katoh, Norio Suzuki, Kazuhiko Igarashi, Mitsuhiro Ito, Hozumi Motohashi, Masayuki Yamamoto

    Molecular and cellular biology　36　(3)　407-20　2016/02/01

    DOI： 10.1128/MCB.00785-15 　

    ISSN： 0270-7306

  41. Efficacy estimation of erythropoiesis-stimulating agents using erythropoietin-deficient anemic mice Peer-reviewed

    Norio Suzuki, Yusuke Sasaki, Koichiro Kato, Shun Yamazaki, Mitsue Kurasawa, Keigo Yorozu, Yasushi Shimonaka, Masayuki Yamamoto

    Haematologica　101　(9)　e356-e360　2016

    DOI： 10.3324/haematol.2015.140814 　

    ISSN： 0390-6078

    eISSN： 1592-8721

  42. Roles of renal erythropoietin-producing (REP) cells in the maintenance of systemic oxygen homeostasis Peer-reviewed

    Norio Suzuki, Masayuki Yamamoto

    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY　468　(1)　3-12　2016/01

    DOI： 10.1007/s00424-015-1740-2 　

    ISSN： 0031-6768

    eISSN： 1432-2013

  43. 【腎線維化】腎線維化と腎性貧血 Peer-reviewed

    相馬 友和, 鈴木 教郎

    日本腎臓学会誌　57　(7)　1193-1199　2015/10

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  44. Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes. International-journal Peer-reviewed

    Yutaka Tojo, Hiroki Sekine, Ikuo Hirano, Xiaoqing Pan, Tomokazu Souma, Tadayuki Tsujita, Shin-ichi Kawaguchi, Norihiko Takeda, Kotaro Takeda, Guo-Hua Fong, Takashi Dan, Masakazu Ichinose, Toshio Miyata, Masayuki Yamamoto, Norio Suzuki

    Molecular and cellular biology　35　(15)　2658-72　2015/08

    DOI： 10.1128/MCB.00161-15 　

    ISSN： 0270-7306

  45. 【酸素シグナルが細胞機能を揺り動かす!NormoxiaからHypoxiaまで全身で行われるファインチューニング】赤血球造血制御による個体レベルの酸素恒常性維持機構 Peer-reviewed

    鈴木 教郎

    実験医学　33　(11)　1724-1730　2015/07

    Publisher: (株)羊土社

    ISSN： 0288-5514

  46. 【新しい腎性貧血治療ガイドラインへの期待】トピックス EPO産生制御機構 Peer-reviewed

    祢津 昌広, 鈴木 教郎, 山本 雅之

    腎と透析　79　(1)　88-93　2015/07

    Publisher: (株)東京医学社

    ISSN： 0385-2156

  47. 赤血球増殖因子の産生機構の解明 Peer-reviewed

    鈴木 教郎

    東北医学雑誌　127　(1)　26-28　2015/06

    Publisher: 東北医学会

    ISSN： 0040-8700

  48. Renal erythropoietin-producing cells in health and disease Peer-reviewed

    Tomokazu Souma, Norio Suzuki, Masayuki Yamamoto

    FRONTIERS IN PHYSIOLOGY　6　167　2015/06

    DOI： 10.3389/fphys.2015.00167 　

    ISSN： 1664-042X

  49. In Vivo Regulation of Erythropoiesis by Chemically Inducible Dimerization of the Erythropoietin Receptor Intracellular Domain Peer-reviewed

    Norio Suzuki, Harumi Y. Mukai, Masayuki Yamamoto

    PLoS ONE　10　(3)　e0119442　2015/03/19

    DOI： 10.1371/journal.pone.0119442 　

    ISSN： 1932-6203

    eISSN： 1932-6203

  50. Erythropoietin Gene Expression: Developmental-Stage Specificity, Cell-Type Specificity, and Hypoxia Inducibility Peer-reviewed

    Norio Suzuki

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　235　(3)　233-240　2015/03

    DOI： 10.1620/tjem.235.233 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  51. [Renal fibrosis and anemia]. Peer-reviewed

    Souma T, Suzuki N

    Nihon Jinzo Gakkai shi　57　(7)　1193-1199　2015

    ISSN： 0385-2385

  52. Erythropoietin production in neuroepithelial and neural crest cells during primitive erythropoiesis Peer-reviewed

    Norio Suzuki, Ikuo Hirano, Xiaoqing Pan, Naoko Minegishi, Masayuki Yamamoto

    NATURE COMMUNICATIONS　4　2902　2013/12

    DOI： 10.1038/ncomms3902 　

    ISSN： 2041-1723

  53. Plasticity of Renal Erythropoietin-Producing Cells Governs Fibrosis Peer-reviewed

    Tomokazu Souma, Shun Yamazaki, Takashi Moriguchi, Norio Suzuki, Ikuo Hirano, Xiaoqing Pan, Naoko Minegishi, Michiaki Abe, Hideyasu Kiyomoto, Sadayoshi Ito, Masayuki Yamamoto

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　24　(10)　1599-1616　2013/10

    DOI： 10.1681/ASN.2013010030 　

    ISSN： 1046-6673

    eISSN： 1533-3450

  54. Diabetic nephropathy: are there new and potentially promising therapies targeting oxygen biology? Peer-reviewed

    Toshio Miyata, Norio Suzuki, Charles van Ypersele de Strihou

    KIDNEY INTERNATIONAL　84　(4)　693-702　2013/10

    DOI： 10.1038/ki.2013.74 　

    ISSN： 0085-2538

    eISSN： 1523-1755

  55. Erythropoietin contributes to slow oxidative muscle fiber specification via PGC-1 alpha and AMPK activation Peer-reviewed

    Li Wang, Yi Jia, Heather Rogers, Norio Suzuki, Max Gassmann, Qian Wang, Alexandra C. McPherron, Jeffery B. Kopp, Masayuki Yamamoto, Constance Tom Noguchi

    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY　45　(7)　1155-1164　2013/07

    DOI： 10.1016/j.biocel.2013.03.007 　

    ISSN： 1357-2725

  56. A mouse model of adult-onset anaemia due to erythropoietin deficiency Peer-reviewed

    Shun Yamazaki, Tomokazu Souma, Ikuo Hirano, Xiaoqing Pan, Naoko Minegishi, Norio Suzuki, Masayuki Yamamoto

    NATURE COMMUNICATIONS　4　1950　2013/06

    DOI： 10.1038/ncomms2950 　

    ISSN： 2041-1723

  57. The performance of Tohoku University on the innovation of academically driven drug discovery using chemical library Peer-reviewed

    Sugawara Akira, Aoki Junken, Dan Takashi, Shimizu Ritsuko, Suzuki Norio, Kano Kuniyuki, Okudaira Shinichi, Hakoda Akiko, Kaneko Hiroshi, Uchida Takafurni, Nakazawa Toru, Doi Takayuki, Miyata Toshio, Oshima Yoshiteru, Yamamoto Masayuki

    JOURNAL OF PHARMACOLOGICAL SCIENCES　121　50P-50P　2013

    ISSN： 1347-8613

  58. Clinical nephrology 尿細管・間質障害 エリスロポイエチン遺伝子の転写制御機構 Peer-reviewed

    相馬 友和, 鈴木 教郎, 山本 雅之

    Annual Review腎臓　2013　204-211　2013/01

    Publisher: (株)中外医学社

  59. 【低酸素のバイオロジー】低酸素応答の臓器特異的制御 組織特異的・低酸素誘導的なエリスロポエチン遺伝子発現制御機構 Peer-reviewed

    鈴木 教郎

    血管医学　13　(4)　333-339　2012/11

    Publisher: (株)メディカルレビュー社

    ISSN： 1345-9031

  60. Epigenetic regulation of hypoxia-dependent erythropoietin gene expression Peer-reviewed

    Norio Suzuki, Xiaoqing Pan, Yutaka Tojo, Takashi Dan, Toshio Miyata, Lorenz Poellinger, Masayuki Yamamoto

    AMERICAN JOURNAL OF HEMATOLOGY　87　(10)　E99-E99　2012/10

    ISSN： 0361-8609

  61. Endogenous erythropoietin signaling facilitates skeletal muscle repair and recovery following pharmacologically induced damage Peer-reviewed

    Yi Jia, Norio Suzuki, Masayuki Yamamoto, Max Gassmann, Constance Tom Noguchi

    FASEB JOURNAL　26　(7)　2847-2858　2012/07

    DOI： 10.1096/fj.11-196618 　

    ISSN： 0892-6638

  62. Disrupted erythropoietin signalling promotes obesity and alters hypothalamus proopiomelanocortin production Peer-reviewed

    Ruifeng Teng, Oksana Gavrilova, Norio Suzuki, Tatyana Chanturiya, Daniel Schimel, Lynne Hugendubler, Selin Mammen, Dena R. Yver, Samuel W. Cushman, Elisabetta Mueller, Masayuki Yamamoto, Lewis L. Hsu, Constance Tom Noguchi

    NATURE COMMUNICATIONS　2　520　2011/11

    DOI： 10.1038/ncomms1526 　

    ISSN： 2041-1723

  63. Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice Peer-reviewed

    Nariaki Asada, Masayuki Takase, Jin Nakamura, Akiko Oguchi, Misako Asada, Norio Suzuki, Ken-ichi Yamarnura, Narihito Nagoshi, Shinsuke Shibata, Tata Nageswara Rao, Hans Joerg Fehling, Atsushi Fukatsu, Naoko Minegishi, Toru Kita, Takeshi Kimura, Hideyuki Okano, Masayuki Yamamoto, Motoko Yanagita

    JOURNAL OF CLINICAL INVESTIGATION　121　(10)　3981-3990　2011/10

    DOI： 10.1172/JCI57301 　

    ISSN： 0021-9738

    eISSN： 1558-8238

  64. Isolation and Characterization of Renal Erythropoietin-Producing Cells from Genetically Produced Anemia Mice Peer-reviewed

    Xiaoqing Pan, Norio Suzuki, Ikuo Hirano, Shun Yamazaki, Naoko Minegishi, Masayuki Yamamoto

    PLOS ONE　6　(10)　e25839　2011/10

    DOI： 10.1371/journal.pone.0025839 　

    ISSN： 1932-6203

  65. Specific Contribution of the Erythropoietin Gene 3 &apos; Enhancer to Hepatic Erythropoiesis after Late Embryonic Stages Peer-reviewed

    Norio Suzuki, Naoshi Obara, Xiaoqing Pan, Miho Watanabe, Kou-Ichi Jishage, Naoko Minegishi, Masayuki Yamamoto

    MOLECULAR AND CELLULAR BIOLOGY　31　(18)　3896-3905　2011/09

    DOI： 10.1128/MCB.05463-11 　

    ISSN： 0270-7306

  66. 【腎臓と貧血】EPO遺伝子の発現制御と産生細胞の同定 Peer-reviewed

    鈴木 教郎, 山本 雅之

    腎と透析　71　(2)　183-191　2011/08

    Publisher: (株)東京医学社

    ISSN： 0385-2156

  67. Acute erythropoietin cardioprotection is mediated by endothelial response Peer-reviewed

    Ruifeng Teng, John W. Calvert, Nathawut Sibmooh, Barbora Piknova, Norio Suzuki, Junhui Sun, Kevin Martinez, Masayuki Yamamoto, Alan N. Schechter, David J. Lefer, Constance Tom Noguchi

    BASIC RESEARCH IN CARDIOLOGY　106　(3)　343-354　2011/05

    DOI： 10.1007/s00395-011-0158-z 　

    ISSN： 0300-8428

  68. HEMATOPOIESIS - CYTOKINES, SIGNAL TRANSDUCTION, APOPTOSIS AND CELL CYCLE REGULATION POSTER I

    Pan, Xiaoqing, Suzuki, Norio, Hirano, Ikuo, Yamazaki, Shun, Yamashita, Toshiharu, Ohneda, Osamu, Minegishi, Naoko, Yamamoto, Masayuki

    BLOOD　116　(21)　656-656　2010/11

    Publisher: AMER SOC HEMATOLOGY

    ISSN： 0006-4971

  69. Isolation and Characterization of Renal Erythropoietin-Producing Cells: Contribution of HIF3 alpha In Vivo

    Pan, Xiaoqing, Suzuki, Norio, Hirano, Ikuo, Yamazaki, Shun, Yamashita, Toshiharu, Ohneda, Osamu, Minegishi, Naoko, Yamamoto, Masayuki

    BLOOD　116　(21)　656-656　2010/11

    Publisher: AMER SOC HEMATOLOGY

    ISSN： 0006-4971

  70. The anemia of the newborn induces erythropoietin expression in the developing mouse retina Peer-reviewed

    N. Scheerer, N. Dünker, S. Imagawa, M. Yamamoto, N. Suzuki, J. Fandrey

    American Journal of Physiology - Regulatory Integrative and Comparative Physiology　299　(1)　R111-R118　2010/07

    DOI： 10.1152/ajpregu.00108.2010 　

    ISSN： 0363-6119 1522-1490

  71. Fractionation of mature eosinophils in GATA-reporter transgenic mice Peer-reviewed

    Kibom Kim, Norio Suzuki, Kinuko Ohneda, Naoko Minegishi, Masayuki Yamamoto

    Tohoku Journal of Experimental Medicine　220　(2)　127-138　2010

    DOI： 10.1620/tjem.220.127 　

    ISSN： 0040-8727 1349-3329

  72. GATA2-dependent and region-specific regulation of Gata2 transcription in the mouse midbrain Peer-reviewed

    Daisuke Nozawa, Norio Suzuki, Maki Kobayashi-Osaki, Xiaoqing Pan, James Douglas Engel, Masayuki Yamamoto

    GENES TO CELLS　14　(5)　569-582　2009/05

    DOI： 10.1111/j.1365-2443.2009.01289.x 　

    ISSN： 1356-9597

  73. Krüppel-like factor 5 Is Essential for Blastocyst Development and the Normal Self-Renewal of Mouse ESCs Peer-reviewed

    Masatsugu Ema, Daisuke Mori, Hitoshi Niwa, Yoshikazu Hasegawa, Yojiro Yamanaka, Seiji Hitoshi, Junsei Mimura, Yoh-ichi Kawabe, Tomohiro Hosoya, Masanobu Morita, Daisuke Shimosato, Kazuhiko Uchida, Norio Suzuki, Jun Yanagisawa, Kazuhiro Sogawa, Janet Rossant, Masayuki Yamamoto, Satoru Takahashi, Yoshiaki Fujii-Kuriyama

    Cell Stem Cell　3　(5)　555-567　2008/11/06

    Publisher: 5

    DOI： 10.1016/j.stem.2008.09.003 　

    ISSN： 1934-5909

  74. Repression via the GATA box is essential for tissue-specific erythropoietin gene expression Peer-reviewed

    Naoshi Obara, Norio Suzuki, Kibom Kim, Toshiro Nagasawa, Shigehiko Imagawa, Masayuki Yamamoto

    BLOOD　111　(10)　5223-5232　2008/05

    DOI： 10.1182/blood-2007-10-115857 　

    ISSN： 0006-4971

    eISSN： 1528-0020

  75. Defining the functional boundaries of the Gata2 locus by rescue with a linked bacterial artificial chromosome transgene Peer-reviewed

    William Brandt, Melin Khandekar, Norio Suzuki, Masayuki Yamamoto, Kim-Chew Lim, James Douglas Engel

    JOURNAL OF BIOLOGICAL CHEMISTRY　283　(14)　8976-8983　2008/04

    DOI： 10.1074/jbc.M709364200 　

    ISSN： 0021-9258

  76. Does K-11706 enhance performance and why? Peer-reviewed

    Shigehiko Imagawa, K. Matsumoto, M. Horie, N. Ohkoshi, T. Nagasawa, T. Doi, N. Suzuki, M. Yamamoto

    International Journal of Sports Medicine　28　(11)　928-933　2007/11

    DOI： 10.1055/s-2007-964988 　

    ISSN： 0172-4622

  77. Detection of hypoxia-inducible gene manipulation Peer-reviewed

    Shigehiko Imagawa, Masaki Horie, Ken Matsumoto, Ikuo Hirano, Norio Suzuki, Masayuki Yamamoto

    BLOOD　110　(11)　1069A-1069A　2007/11

    ISSN： 0006-4971

  78. A Gata2 intronic enhancer confers its pan-endothelia-specific regulation Invited Peer-reviewed

    Melin Khandekar, William Brandt, Yinghui Zhou, Susan Dagenais, Thomas W. Glover, Norio Suzuki, Ritsuko Shimizu, Masayuki Yamamoto, Kim-Chew Lim, James Douglas Engel

    Development　134　(9)　1703-1712　2007/05

    DOI： 10.1242/dev.001297 　

    ISSN： 0950-1991

  79. Use of gene-manipulated mice in the study of Erythropoietin gene expression Peer-reviewed

    Norio Suzuki, Naoshi Obara, Masayuki Yamamoto

    OXYGEN BIOLOGY AND HYPOXIA　435　157-+　2007

    DOI： 10.1016/S0076-6879(07)35009-X 　

    ISSN： 0076-6879

  80. Transgene insertion in proximity to the c-myb gene disrupts erythroid-megakaryocytic lineage bifurcation Peer-reviewed

    Harumi Y. Mukai, Hozumi Motohashi, Osamu Ohneda, Norio Suzuki, Masumi Nagano, Masayuki Yamamoto

    MOLECULAR AND CELLULAR BIOLOGY　26　(21)　7953-7965　2006/11

    DOI： 10.1128/MCB.00718-06 　

    ISSN： 0270-7306

  81. 2-Oxoglutarate downregulates expression of vascular endothelial growth factor and erythropoietin through decreasing hypoxia-inducible factor-1 alpha and inhibits angiogenesis Peer-reviewed

    Ken Matsumoto, Shigehiko Imagawa, Naoshi Obara, Norio Suzuki, Satoru Takahashi, Toshiro Nagasawa, Masayuki Yamamoto

    JOURNAL OF CELLULAR PHYSIOLOGY　209　(2)　333-340　2006/11

    DOI： 10.1002/jcp.20733 　

    ISSN： 0021-9541

  82. Transgenic rescue of erythroid 5-aminolevulinate synthase-deficient mice results in the formation of ring sideroblasts and siderocytes Invited Peer-reviewed

    Osamu Nakajima, Satoshi Okano, Hiroko Harada, Toshimasa Kusaka, Xu Gao, Tomonori Hosoya, Norio Suzuki, Satoru Takahashi, Masayuki Yamamoto

    Genes to Cells　11　(6)　685-700　2006/06

    DOI： 10.1111/j.1365-2443.2006.00973.x 　

    ISSN： 1356-9597 1365-2443

  83. Important role of endogenous erythropoietin system in recruitment of endothelial progenitor cells in hypoxia-induced pulmonary hypertension in mice Peer-reviewed

    K Satoh, Y Kagaya, M Nakano, Y Ito, J Ohta, H Tada, A Karibe, N Minegishi, N Suzuki, M Yamamoto, M Ono, J Watanabe, K Shirato, N Ishii, K Sugamura, H Shimokawa

    CIRCULATION　113　(11)　1442-1450　2006/03

    DOI： 10.1161/CIRCULATIONAHA.105.583732 　

    ISSN： 0009-7322

  84. Combinatorial Gata2 and Sca1 expression defines hematopoietic stem cells in the bone marrow niche Invited Peer-reviewed

    Norio Suzuki, Osamu Ohneda, Naoko Minegishi, Mitsuo Nishikawa, Takayuki Ohta, Satoru Takahashi, James Douglas Engel, Masayuki Yamamoto

    Proceedings of the National Academy of Sciences of the United States of America　103　(7)　2202-2207　2006/02/14

    DOI： 10.1073/pnas.0508928103 　

    ISSN： 0027-8424

  85. 2-oxoglutarateによる血管形成抑制 Peer-reviewed

    松本 健, 今川 重彦, 小原 直, 鈴木 教郎, 長澤 俊郎, 山本 雅之

    医学のあゆみ　215　(2)　158-159　2005/10

    Publisher: 医歯薬出版(株)

    ISSN： 0039-2359

  86. Enhanced erythropoiesis mediated by activation of the renin-angiotensin system via angiotensin II type 1a receptor Peer-reviewed

    H Kato, J Ishida, S Imagawa, T Saito, N Suzuki, T Matsuoka, T Sugaya, K Tanimoto, T Yokoo, O Ohneda, F Sugiyama, K Yagami, T Fujita, M Yamamoto, M Nangaku, A Fukamizu

    FASEB JOURNAL　19　(12)　2023-+　2005/10

    DOI： 10.1096/fj.05-3820fje 　

    ISSN： 0892-6638

  87. GATA motifs regulate early hematopoietic lineage-specific expression of the Gata2 gene Invited Peer-reviewed

    Maki Kobayashi-Osaki, Osamu Ohneda, Norio Suzuki, Naoko Minegishi, Tomomasa Yokomizo, Satoru Takahashi, Kim-Chew Lim, James Douglas Engel, Masayuki Yamamoto

    Molecular and Cellular Biology　25　(16)　7005-7020　2005/08

    DOI： 10.1128/MCB.25.16.7005-7020.2005 　

    ISSN： 0270-7306

  88. Rapid turnover of GATA-2 via ubiquitin-proteasome protein degradation pathway Invited Peer-reviewed

    Naoko Minegishi, Norio Suzuki, Yukie Kawatani, Ritsuko Shimizu, Masayuki Yamamoto

    Genes to Cells　10　(7)　693-704　2005/07

    DOI： 10.1111/j.1365-2443.2005.00864.x 　

    ISSN： 1356-9597

  89. Multiple, distant Gata2 enhancers specify temporally and tissue-specific patterning in the developing urogenital system Peer-reviewed

    Melin Khandekar, Norio Suzuki, Jon Lewton, Masayuki Yamamoto, James Douglas Engel

    Molecular and Cellular Biology　24　(23)　10263-10276　2004/12

    DOI： 10.1128/MCB.24.23.10263-10276.2004 　

    ISSN： 0270-7306

  90. Oral administration of K-11706 inhibits GATA binding activity, enhances hypoxia-inducible factor 1 binding activity, and restores indicators in an in vivo mouse model of anemia of chronic disease Peer-reviewed

    Y Nakano, S Imagawa, K Matsumoto, C Stockmann, N Obara, N Suzuki, T Doi, T Kodama, S Takahashi, T Nagasawa, M Yamamoto

    BLOOD　104　(13)　4300-4307　2004/12

    DOI： 10.1182/blood-2004-04-1631 　

    ISSN： 0006-4971

  91. 2-oxoglutarateによるhypoxia inducible factor-1結合活性および蛋白抑制 Peer-reviewed

    松本 健, 今川 重彦, 小原 直, 鈴木 教郎, 長澤 俊郎, 山本 雅之

    医学のあゆみ　211　(7)　785-786　2004/11

    Publisher: 医歯薬出版(株)

    ISSN： 0039-2359

  92. Do beta-globin, GATA-1, or EpoR regulatory domains specifically mark erythroid progenitors in transgenic reporter mice? Peer-reviewed

    N Suzuki, S Imagawa, CT Noguchi, M Yamamoto

    BLOOD　104　(9)　2988-2988　2004/11

    DOI： 10.1182/blood-2004-06-2081 　

    ISSN： 0006-4971

  93. 2-oxoglutarateによるvascular endothelial growth factorおよびerythropoetin産生抑制 Peer-reviewed

    今川 重彦, 松本 健, 小原 直, 鈴木 教郎, 長澤 俊郎, 山本 雅之

    医学のあゆみ　211　(4)　347-348　2004/10

    Publisher: 医歯薬出版(株)

    ISSN： 0039-2359

  94. A constitutively active arylhydrocarbon receptor induces growth inhibition of jurkat T cells through changes in the expression of genes related to apoptosis and cell cycle arrest Peer-reviewed

    Tomohiro Ito, Shin-Ichi Tsukumo, Norio Suzuki, Hozumi Motohashi, Masayuki Yamamoto, Yoshiaki Fujii-Kuriyama, Junsei Mimura, Tien-Min Lin, Richard E. Peterson, Chiharu Tohyama, Keiko Nohara

    Journal of Biological Chemistry　279　(24)　25204-25210　2004/06/11

    DOI： 10.1074/jbc.M402143200 　

    ISSN： 0021-9258

  95. 新規GATA阻害薬の経口投与による慢性貧血治療の試み Peer-reviewed

    中野 陽子, 今川 重彦, 小原 直, 鈴木 教郎, 長澤 俊郎, 山本 雅之

    医学のあゆみ　208　(3)　177-178　2004/01

    Publisher: 医歯薬出版(株)

    ISSN： 0039-2359

  96. Interleukin-6 and Tumor Necrosis Factor-α in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome Invited Peer-reviewed

    S. Imagawa, Y. Yamaguchi, K. Ogawa, N. Obara, N. Suzuki, M. Yamamoto, T. Nagasawa

    Respiration　71　(1)　24-29　2004

    DOI： 10.1159/000075645 　

    ISSN： 0025-7931

  97. Identification and characterization of 2 types of erythroid progenitors that express GATA-1 at distinct levels Peer-reviewed

    Norio Suzuki, Naruyoshi Suwabe, Osamu Ohneda, Naoshi Obara, Shigehiko Imagawa, Xiaoqing Pan, Hozumi Motohashi, Masayuki Yamamoto

    Blood　102　(10)　3575-3583　2003/11/15

    DOI： 10.1182/blood-2003-04-1154 　

    ISSN： 0006-4971

  98. Expression and domain-specific function of GATA-2 during differentiation of the hematopoietic precursor cells in midgestation mouse embryos Invited Peer-reviewed

    Naoko Minegishi, Norio Suzuki, Tomomasa Yokomizo, Xiaoqing Pan, Tetsuhiro Fujimoto, Satoru Takahashi, Takahiko Hara, Atsushi Miyajima, Shin-ichi Nishikawa, Masayuki Yamamoto

    Blood　102　(3)　896-905　2003/08/01

    DOI： 10.1182/blood-2002-12-3809 　

    ISSN： 0006-4971

  99. A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1 beta, TNF-alpha, or L-NMMA Peer-reviewed

    S Imagawa, Y Nakano, N Obara, N Suzuki, T Doi, T Kodama, T Nagasawa, M Yamamoto

    FASEB JOURNAL　17　(10)　1742-+　2003/07

    DOI： 10.1096/fj.02-1134fje 　

    ISSN： 0892-6638

  100. Suppression of erythropoietin gene expression by cadmium depends on inhibition of HIF-1, not stimulation of GATA-2 Peer-reviewed

    N Obara, S Imagawa, Y Nakano, N Suzuki, M Yamamoto, T Nagasawa

    ARCHIVES OF TOXICOLOGY　77　(5)　267-273　2003/05

    DOI： 10.1007/s00204-003-0444-0 　

    ISSN： 0340-5761

  101. 二次性貧血に対する新規治療薬の開発 Peer-reviewed

    今川 重彦, 中野 陽子, 小原 直, 鈴木 教郎, 土肥 武, 児玉 龍彦, 長澤 俊郎, 山本 雅之

    医学のあゆみ　204　(12)　903-904　2003/03

    Publisher: 医歯薬出版(株)

    ISSN： 0039-2359

  102. HLF/HIF-2 alpha is a key factor in retinopathy of prematurity in association with erythropoietin Peer-reviewed

    M Morita, O Ohneda, T Yamashita, S Takahashi, N Suzuki, O Nakajima, S Kawauchi, M Ema, S Shibahara, T Udono, K Tomita, M Tamai, K Sogawa, M Yamamoto, Y Fujii-Kuriyama

    EMBO JOURNAL　22　(5)　1134-1146　2003/03

    DOI： 10.1093/emboj/cdg117 　

    ISSN： 0261-4189

  103. Hemogenic and nonhemogenic endothelium can be distinguished by the activity of fetal liver kinase (Flk)-1 promoter/enhancer during mouse embryogenesis Invited Peer-reviewed

    Hideyo Hirai, Minetaro Ogawa, Norio Suzuki, Masayuki Yamamoto, Georg Breier, Osam Mazda, Jiro Imanishi, Shin-Ichi Nishikawa

    Blood　101　(3)　886-893　2003/02/01

    DOI： 10.1182/blood-2002-02-0655 　

    ISSN： 0006-4971

  104. 新規エリスロポエチン発現促進剤(K-7174) 腎性貧血への試み Peer-reviewed

    今川 重彦, 中野 陽子, 小原 直, 鈴木 教郎, 土肥 武, 児玉 龍彦, 長澤 俊郎, 山本 雅之

    医学のあゆみ　204　(4)　291-292　2003/01

    Publisher: 医歯薬出版(株)

    ISSN： 0039-2359

  105. Erythroid-specific expression of the erythropoietin receptor rescued its null mutant mice from lethality Peer-reviewed

    N Suzuki, O Ohneda, S Takahashi, M Higuchi, HY Mukai, T Nakahata, S Imagawa, M Yamamoto

    BLOOD　100　(7)　2279-2288　2002/10

    DOI： 10.1182/blood-2002-01-0124 　

    ISSN： 0006-4971

  106. GATA suppresses erythropoietin gene expression through GATA site in mouse erythropoietin gene promoter Peer-reviewed

    S Imagawa, N Suzuki, K Ohmine, N Obara, HY Mukai, K Ozawa, M Yamamoto, T Nagasawa

    INTERNATIONAL JOURNAL OF HEMATOLOGY　75　(4)　376-381　2002/05

    DOI： 10.1007/BF02982127 　

    ISSN： 0925-5710

  107. L-arginine rescues decreased erythropoietin gene expression by stimulating GATA-2 with L-NMMA Peer-reviewed

    S Imagawa, T Tarumoto, N Suzuki, HY Mukai, Y Hasegawa, M Higuchi, T Neichi, K Ozawa, M Yamamoto, T Nagasawa

    KIDNEY INTERNATIONAL　61　(2)　396-404　2002/02

    DOI： 10.1046/j.1523-1755.2002.00152.x 　

    ISSN： 0085-2538

  108. マウスGATA-2によるマウスエリスロポエチン遺伝子の発現抑制 Peer-reviewed

    今川 重彦, 鈴木 教郎, 大嶺 謙, 小原 直, 向井 陽美, 長谷川 雄一, 山本 雅之, 長澤 俊郎

    医学のあゆみ　198　(10)　731-732　2001/09

    Publisher: 医歯薬出版(株)

    ISSN： 0039-2359

  109. Levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea-hypopnea syndrome Peer-reviewed

    Shigehiko Imagawa, Yuji Yamaguchi, Masato Higuchi, Tomohiro Neichi, Yuichi Hasegawa, Harumi Y. Mukai, Norio Suzuki, Masayuki Yamamoto, Toshiro Nagasawa

    Blood　98　(4)　1255-1257　2001/08/15

    DOI： 10.1182/blood.V98.4.1255 　

    ISSN： 0006-4971

  110. NG-monomethyl-L-arginine(L-NMMA)のGATA-2促進によるEpo産生低下はL-arginineにより改善する Peer-reviewed

    今川 重彦, 樽本 高寿, 向井 陽美, 長谷川 雄一, 鈴木 教郎, 樋口 正人, 今井 信雄, 山本 雅之, 長澤 俊郎

    医学のあゆみ　196　(3)　229-230　2001/01

    Publisher: 医歯薬出版(株)

    ISSN： 0039-2359

  111. N(G)-monomethyl-L-arginine inhibits erythropoietin gene expression by stimulating GATA-2 Peer-reviewed

    T. Tarumoto, S. Imagawa, K. Ohmine, T. Nagai, M. Higuchi, N. Imai, N. Suzuki, M. Yamamoto, K. Ozawa

    Blood　96　(5)　1716-1722　2000/09/01

    ISSN： 0006-4971

  112. The mouse GATA-2 gene is expressed in the para-aortic splanchnopleura and aorta-gonads and mesonephros region Peer-reviewed

    Naoko Minegishi, Jun Ohta, Hironori Yamagiwa, Norio Suzuki, Shimako Kawauchi, Yinghui Zhou, Satoru Takahashi, Norio Hayashi, James Douglas Engel, Masayuki Yamamoto

    Blood　93　(12)　4196-4207　1999/06/15

    ISSN： 0006-4971

Show all ︎Show first 5

Misc. 123

  1. Genetically modified mouse lines for investigating molecular pathology of renal anemia

    中井琢, 鈴木教郎

    腎と透析　91　(5)　2021

    ISSN： 0385-2156

  2. 【腎性貧血治療のこれまでと,その新しい展開】腎性貧血の発症機序

    宮崎 真理子, 宮内 健一郎, 佐藤 浩司, 鈴木 教郎

    臨床透析　37　(1)　13-18　2021/01

    Publisher: (株)日本メディカルセンター

    ISSN： 0910-5808

    eISSN： 2433-247X

  3. 【腎臓の構成細胞から再考する:基礎と臨床】間質の間質細胞・血管構成細胞 腎間質構成細胞の特徴と機能

    佐藤 浩司, 鈴木 教郎

    腎と透析　89　(3)　402-407　2020/09

    Publisher: (株)東京医学社

    ISSN： 0385-2156

  4. 腎疾患を生化学的に解明する 腎臓エリスロポエチン産生細胞による個体レベルの低酸素応答機構

    鈴木 教郎

    日本生化学会大会プログラム・講演要旨集　93回　[1S03m-04]　2020/09

    Publisher: (公社)日本生化学会

  5. 低酸素誘導転写因子HIFを活性化する薬剤が病態腎の赤血球造血因子産生を再活性化する機序の検討

    中井 琢, 加藤 幸一郎, 鈴木 教郎

    日本生化学会大会プログラム・講演要旨集　93回　[3Z10-609)]　2020/09

    Publisher: (公社)日本生化学会

  6. 血管による酸素運搬は加齢関連疾患の発症にどう関係するか? 慢性貧血による疾患素地形成の可能性

    鈴木 教郎

    日本抗加齢医学会総会プログラム・抄録集　20回　111-111　2020/09

    Publisher: (一社)日本抗加齢医学会

  7. 【線維化 慢性疾患のキープロセス 多彩な間質細胞が織りなす組織リモデリング"fibrosis"の理解】(第1章)線維芽細胞の多様性 腎臓間質の線維芽細胞

    鈴木 教郎

    実験医学　38　(12)　1975-1981　2020/08

    Publisher: (株)羊土社

    ISSN： 0288-5514

  8. 新しい腎性貧血治療薬としてのHIF-PHD阻害薬〜これを聞けば全てが分かります〜 EPO産生能を喪失した障害腎でのHIF-PHD阻害薬によるEPO産生誘導機序

    鈴木 教郎

    日本腎臓学会誌　62　(4)　237-237　2020/07

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  9. 【酸素環境と臓器機能 感知・応答のメカニズムから最新の酸素イメージングまで】腎間質線維芽細胞による全身の酸素恒常性維持機構

    中井 琢, 鈴木 教郎

    実験医学　38　(9)　1451-1457　2020/06

    Publisher: (株)羊土社

    ISSN： 0288-5514

  10. 二次性多血症を呈したFSGS男児例における腎移植前精査

    白井 陽子, 三浦 健一郎, 安藤 太郎, 飯田 貴也, 白鳥 孝俊, 薮内 智朗, 金子 直人, 石和 翔, 石塚 喜世伸, 藤永 周一郎, 鈴木 教郎, 服部 元史

    日本臨床腎移植学会プログラム・抄録集　53回　195-195　2020/02

    Publisher: (一社)日本臨床腎移植学会

  11. EPO産生能を喪失した障害腎でのHIF-PHD阻害薬によるEPO産生誘導機序

    鈴木教郎

    日本腎臓学会誌(Web)　62　(4)　2020

    ISSN： 1884-0728

  12. CKD合併症最新の話題 貧血状態の腎臓における酸素恒常性の維持のためのエリスロポエチンとレニン産生の誘導(Induction of erythropoietin and renin production in kidneys under anemic conditions to maintain oxygen homeostasis)

    宮内 健一郎, 伊藤 貞嘉, 山本 雅之, 鈴木 教郎

    日本腎臓学会誌　61　(3)　235-235　2019/05

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  13. 腎エリスロポエチン産生細胞(REP細胞)由来の細胞株は、細胞自律性TGFβ発現により筋線維芽細胞の形質を有する

    佐藤 浩司, 平野 育生, 関根 弘樹, 宮内 健一郎, 中井 啄, 加藤 幸一郎, 伊藤 貞嘉, 山本 雅之, 鈴木 教郎

    日本生化学会大会プログラム・講演要旨集　91回　[3T12m-019)]　2018/09

    Publisher: (公社)日本生化学会

  14. 低酸素生物学:ミトコンドリア呼吸、代謝、遺伝子発現、細胞分化・組織再生から臨床応用へ 赤血球増殖因子エリスロポエチンの低酸素誘導的産生制御機構

    鈴木 教郎

    日本生化学会大会プログラム・講演要旨集　91回　[3S08a-04]　2018/09

    Publisher: (公社)日本生化学会

  15. Roles of renal erythropoietin-producing (REP) cells in renal anemia and fibrosis Peer-reviewed

    佐藤 浩司, 鈴木 教郎

    腎臓内科・泌尿器科 = Nephrology & urology　7　(4)　357-362　2018/04

    Publisher: 科学評論社

    ISSN： 2188-9147

  16. Crosstalk between oxygen environment and erythropoiesis Peer-reviewed

    鈴木 教郎

    細胞　50　(4)　184-187　2018/04

    Publisher: ニューサイエンス社

    ISSN： 1346-7557

  17. 内因性エリスロポエチンの腎保護作用の検討

    田中真生, 高瀬昌幸, 金子惠一, 佐藤有紀, 鈴木教郎, 山本雅之, 柳田素子

    日本腎臓学会誌　60　(3)　463-463　2018/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  18. 腎性貧血モデルマウスを用いた心腎貧血連関の機序解明

    鈴木 教郎

    医科学応用研究財団研究報告　35　297-300　2018/02

    Publisher: (公財)鈴木謙三記念医科学応用研究財団

    ISSN： 0914-5117

    eISSN： 2185-2561

  19. Maintenance of Oxygen Homeostasis by Erythropoietic Regulation Peer-reviewed

    鈴木 教郎

    臨床病理 = The official journal of Japanese Society of Laboratory Medicine : 日本臨床検査医学会誌　66　(1)　86-93　2018/01

    Publisher: 日本臨床検査医学会 ; 1953-

    ISSN： 0047-1860

  20. 貧血は低血圧を招来し腎レニン発現を誘導する

    宮内健一郎, 加藤幸一郎, 祢津昌宏, 齋藤さかえ, 佐藤浩司, 山本雅之, 鈴木教郎

    日本生化学会大会(Web)　2017年度　[2LBA-101]　2017/12

    Publisher: 生命科学系学会合同年次大会運営事務局

  21. 酸素恒常性維持における赤血球造血系の役割とその破綻による病態への影響

    鈴木教郎

    臨床化学　46　(Suppl.1)　141-141　2017/09

    Publisher: (一社)日本臨床化学会

    ISSN： 0370-5633

  22. エリスロポエチン欠損は腎臓における慢性的代償機能を破綻させる(Erythropoietin maintains long-term compensatory renal hypertrophy)

    中野 大介, 管 う, 鈴木 教郎, 山本 雅之, 西山 成

    The Journal of Toxicological Sciences　42　(Suppl.)　S205-S205　2017/06

    Publisher: (一社)日本毒性学会

    ISSN： 0388-1350

    eISSN： 1880-3989

  23. 低酸素と酸化ストレスに対する生体防御機構の腎臓での役割

    鈴木教郎

    日本腎臓学会誌　59　(3)　206　2017/04/25

    ISSN： 0385-2385

  24. 抗酸化ストレス転写因子Nrf2による腎障害進展抑制機構の解明

    祢津 昌広, 相馬 友和, 伊藤 貞嘉, 鈴木 教郎, 山本 雅之

    日本臨床分子医学会学術総会プログラム・抄録集　54回　53-53　2017/04

    Publisher: 日本臨床分子医学会

  25. エリスロポエチンはネフロンロスに対する長期腎代償性機構に必須である

    中野大介, GUAN Yu, 鈴木教郎, 山本雅之, 西山成

    日本腎臓学会誌　59　(3)　263-263　2017/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  26. Erythropoietin maintains long-term compensatory renal hypertrophy

    NAKANO Daisuke, GUAN Yu, SUZUKI Norio, YAMAMOTO Masayuki, NISHIYAMA Akira

    Annual Meeting of the Japanese Society of Toxicology　44　(0)　O-54　2017

    Publisher: The Japanese Society of Toxicology

    DOI： 10.14869/toxpt.44.1.0_O-54 　

    More details Close

    Kidney has ability to adapt its size and function against partial nephron loss to maintain total renal function, for example, in both donor and recipient in renal transplantation. However, the factors that regulate this compensation have not been fully clarified yet. Hereby we examined the effects of erythropoietin (EPO)/anemia on the compensatory renal hypertrophy in the mice lacking EPO production. The anemic mice showed similar compensatory renal hypertrophy compared to normoxemic mice at week 1 after unilateral nephrectomy (UNX). However, the compensation was disrupted only in anemic mice at week 4 after UNX, which was accompanied by the decreased phosphorylation of ribosomal protein S6, a marker of mTOR activation. In the renal interstitium of anemic mice at week 4 of UNX, the number of cells promoting epo gene transcription (but disable to produce EPO protein in the mice) was reduced even under the anemia, and the number of α-smooth muscle actin-positive cells was increased, suggesting the transdifferentiation of EPO-producing cells into myofibroblast. These changes were restored by the supplementation of recombinant EPO. In conclusion, EPO is not essential for the onset of compensatory renal hypertrophy after UNX, but is essential to maintain the compensation persistently.

  27. エリスロポエチン産生細胞の同定と機能解析 Peer-reviewed

    宮内健一郎, 鈴木教郎

    最新医学　71　(12)　2495-2500　2016/12

    Publisher: 最新医学社

    ISSN： 0370-8241

  28. 妊娠高血圧マウスでは、Nrf2の欠損は、胎盤血管の発育を促し、周産期合併症を改善させる

    祢津 昌広, 相馬 友和, 于 磊, 伊藤 貞嘉, 高橋 信行, 鈴木 教郎, 山本 雅之

    日本高血圧学会総会プログラム・抄録集　39回　324-324　2016/09

    Publisher: (NPO)日本高血圧学会

  29. 低酸素と疾患 低酸素に対する赤血球新生応答(Hypoxia and Disease Erythropoietic response to hypoxia)

    鈴木 教郎

    日本生化学会大会プログラム・講演要旨集　89回　[2S09-1(Introduction included)]　2016/09

    Publisher: (公社)日本生化学会

  30. エリスロポエチンによる赤血球の代謝制御

    福田 愛菜, 加藤 幸一郎, 河野 あかり, 齋藤 さかえ, 山本 雅之, 鈴木 教郎

    日本生化学会大会プログラム・講演要旨集　89回　[3P-035]　2016/09

    Publisher: (公社)日本生化学会

  31. 転写因子NRF1のOGT-HCF-1複合体を介した分解制御機構

    関根 弘樹, 加藤 幸一郎, 福田 愛菜, 鈴木 教郎, 岡崎 慶斗, アラム・モルシェッド, 辻田 忠志, 小林 聡, 山本 雅之, 本橋 ほづみ

    日本生化学会大会プログラム・講演要旨集　89回　[3P-111]　2016/09

    Publisher: (公社)日本生化学会

  32. 低酸素シグナルのニューバイオロジー 低酸素応答における赤血球造血誘導

    鈴木 教郎

    日本抗加齢医学会総会プログラム・抄録集　16回　87-87　2016/06

    Publisher: (一社)日本抗加齢医学会

  33. Renal erythropoietin-producing cells and tubular interstitial cells in kidney development Peer-reviewed

    鈴木 教郎, 山本 雅之

    医学のあゆみ　257　(11)　1151-1155　2016/06

    Publisher: 医歯薬出版

    ISSN： 0039-2359

  34. 尿細管におけるNrf2の活性化が腎虚血再灌流障害による尿細管障害の進行を抑制する分子メカニズムの解明

    祢津 昌広, 相馬 友和, 于 磊, 鈴木 隆史, 三枝 大輔, 伊藤 貞嘉, 鈴木 教郎, 山本 雅之

    日本腎臓学会誌　58　(3)　365-365　2016/05

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  35. 飽和脂肪酸(パルミチン酸)による小胞体ストレスを介したエリスロポエチン産生制御機能の破綻

    Anusornvongchai Thitinun, 岡田 啓, 中谷 嘉寿, 南学 正臣, 鈴木 教郎, 山本 雅之, 稲城 玲子

    Pharma Medica　34　(4)　117-117　2016/04

    Publisher: (株)メディカルレビュー社

    ISSN： 0289-5803

  36. 【腎性貧血の未来医療に向けて】REP細胞におけるEPO産生制御機構 Peer-reviewed

    鈴木 教郎

    腎・高血圧の最新治療　5　(2)　63-68　2016/04

    Publisher: (有)フジメディカル出版

    ISSN： 2187-0004

  37. エリスロポエチンによる赤血球造血の新規メカニズム解明

    鈴木 教郎

    先進医薬研究振興財団研究成果報告集　2015年度　142-143　2016/03

    Publisher: (公財)先進医薬研究振興財団

    ISSN： 2189-1303

  38. 造血因子エリスロポエチンの産生機序から理解する慢性腎臓病の分子病態

    鈴木 教郎

    第一三共生命科学研究振興財団研究報告集　32　87-92　2016

    Publisher: 第一三共生命科学研究振興財団

  39. NRF2-MED16を介した抗酸化遺伝子群の転写活性化機構

    岡崎 慶斗, 関根 弘樹, 鈴木 教郎, 加藤 恭丈, 五十嵐 和彦, 伊藤 光宏, 本橋 ほづみ, 山本 雅之

    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　88回・38回　[4T14L-01(3P0701)]　2015/12

    Publisher: (公社)日本生化学会

  40. エリスロポエチン遺伝子の腎特異的転写制御領域の解析と腎性貧血モデルマウスの樹立

    平野育生, 鈴木教郎, 祢津昌広, 関根弘樹, 相馬友和, 峯岸直子, 清水律子, 山本雅之

    日本生化学会大会(Web)　88回・38回　[4T5L-10(3P0698)]　2015/12

    Publisher: (公社)日本生化学会

  41. 飽和脂肪酸(パルミチン酸)による腎臓早期老化 小胞体ストレスによる造血ホルモン産生制御機能の破綻

    稲城 玲子, Anusonvongchai Thitinun, 鈴木 教郎, 山本 雅之, 南学 正臣

    基礎老化研究　39　(2)　55-55　2015/05

    Publisher: 日本基礎老化学会

    ISSN： 0912-8921

  42. 飽和脂肪酸(パルミチン酸)による腎臓早期老化 小胞体ストレスによる造血ホルモン産生制御機能の破綻

    稲城 玲子, Thitinun Anusonvongchai, 鈴木 教郎, 山本 雅之, 南学 正臣

    日本抗加齢医学会総会プログラム・抄録集　15回　211-211　2015/05

    Publisher: (一社)日本抗加齢医学会

  43. 飽和脂肪酸(パルミチン酸)による腎臓早期老化 小胞体ストレスによる造血ホルモン産生制御機能の破綻

    稲城 玲子, Anusonvongchai Thitinun, 鈴木 教郎, 山本 雅之, 南学 正臣

    日本老年医学会雑誌　52　(Suppl.)　148-148　2015/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  44. 飽和脂肪酸(パルミンチン酸)は小胞体ストレスを介して腎EPO産生細胞の機能破綻を招く

    Anusornvongchai Thitinun, 本西 秀太, 鈴木 教郎, 山本 雅之, 南学 正臣, 稲城 玲子

    日本腎臓学会誌　57　(3)　473-473　2015/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  45. Hypoxia Inducible Transcription Factors (HIF) and Human Disorders Peer-reviewed

    関根 弘樹, Poellinger Lorenz, 鈴木 教郎

    細胞工学　33　(7)　711-715　2014/06

    Publisher: 学研メディカル秀潤社 ; 1982-

    ISSN： 0287-3796

  46. EPOETIN BETA PEGOL PROMOTES IRON UTILIZATION FOR ERYTHROPOIESIS THROUGH INTENSIVE SUPPRESSION OF SERUM HEPCIDIN LEVELS IN INHERITED SUPER-ANAEMIC MICE

    Yusuke Sasaki, Shun Yamazaki, Ken Fujita, Mitsue Kurasawa, Keigo Yorozu, Yasushi Shimonaka, Norio Suzuki, Masayuki Yamamoto

    NEPHROLOGY DIALYSIS TRANSPLANTATION　29　495-496　2014/05

    ISSN： 0931-0509

    eISSN： 1460-2385

  47. 遺伝性超貧血マウスに対するエポエチン ベータ ペゴル投与後の鉄代謝亢進効果

    佐々木 雄亮, 山嵜 瞬, 藤田 謙, 倉澤 光江, 萬 啓悟, 下中 靖, 鈴木 教郎, 山本 雅之

    日本透析医学会雑誌　47　(Suppl.1)　618-618　2014/05

    Publisher: (一社)日本透析医学会

    ISSN： 1340-3451

    eISSN： 1883-082X

  48. 肝臓エリスロポエチン産生を制御する低酸素誘導経路の個体レベル解析

    東條 裕, 宮田 敏男, 山本 雅之, 鈴木 教郎

    日本生化学会大会プログラム・講演要旨集　86回　2P-333　2013/09

    Publisher: (公社)日本生化学会

  49. HIF-3αによるエリスロポエチン遺伝子発現の抑制的制御

    牧野 塁, 潘 小青, 山嵜 瞬, 平野 育生, 山本 雅之, 鈴木 教郎

    日本生化学会大会プログラム・講演要旨集　86回　2P-337　2013/09

    Publisher: (公社)日本生化学会

  50. Nrf2制御系とAdh3の協調作用による生体防御機構の解析

    後藤 まき, 長谷場 健, 鈴木 教郎, 山本 雅之, 山本 照子, 本橋 ほづみ

    日本生化学会大会プログラム・講演要旨集　86回　3P-182　2013/09

    Publisher: (公社)日本生化学会

  51. Renal erythropoietin-producing cells Peer-reviewed

    鈴木 教郎

    細胞　45　(10)　500-503　2013/09

    Publisher: ニューサイエンス社

    ISSN： 1346-7557

  52. 生体防御におけるNrf2制御系とAdh3の協調作用の重要性

    後藤 まき, 長谷場 健, 鈴木 教郎, 山本 照子, 山本 雅之, 橋本 ほづみ

    生化学　85　(8)　720-720　2013/08

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

  53. 低酸素応答系を介した腫瘍免疫抑制機構への影響

    東條 裕, 山本 雅之, 一ノ瀬 正和, 鈴木 教郎

    生化学　85　(8)　721-721　2013/08

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

  54. 慢性腎臓病における線維化と腎性貧血を担う細胞の同定およびその制御法の開発

    高瀬昌幸, 浅田礼光, 中村仁, 小口綾貴子, 浅田三咲子, 鈴木教郎, 山村研一, 名越慈人, 芝田晋介, RAO Tata Nageswara, FEHLING Hans Joerg, 深津敦司, 峯岸直子, 北徹, 木村剛, 岡野栄之, 山本雅之, 柳田素子

    Pharma Medica　31　(5)　90-92　2013/05

    Publisher: (株)メディカルレビュー社

    ISSN： 0289-5803

  55. 腎線維化を規定する腎エリスロポイエチン産生細胞の形質転換とその可逆性

    相馬 友和, 山崎 瞬, 鈴木 教郎, 森口 尚, 阿部 倫明, 清元 秀泰, 伊藤 貞嘉, 山本 雅之

    日本腎臓学会誌　55　(3)　345-345　2013

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  56. トランスジェニックマウスを利用したエリスロポエチン遺伝子エンハンサーの探索

    平野育生, 鈴木教郎, 山崎瞬, 峯岸直子, 山本雅之, 清水律子

    日本分子生物学会年会プログラム・要旨集(Web)　36th　1P-0195 (WEB ONLY)　2013

  57. エリスロポエチン産生細胞特異的Cre発現マウスの樹立と解析

    山嵜瞬, 峯岸直子, 鈴木教郎, 山本雅之

    日本生化学会大会(Web)　85回　3T01-01　2012/12

    Publisher: (公社)日本生化学会

  58. 神経堤細胞におけるエリスロポエチン遺伝子発現

    平野育生, 鈴木教郎, PAN Xiaoqing, 峯岸直子, 山本雅之

    日本生化学会大会(Web)　85回　3T09-04　2012/12

    Publisher: (公社)日本生化学会

  59. Erythropoietin production in neural crest cells

    Ikuo Hirano, Norio Suzuki, Xiaoqing Pan, Shun Yamazaki, Naoko Minegishi, Masayuki Yamamoto

    AMERICAN JOURNAL OF HEMATOLOGY　87　(10)　E100-E100　2012/10

    ISSN： 0361-8609

  60. エリスロポエチンの造血外機能と産生制御機構の解明

    鈴木 教郎

    生化学　84　(6)　501-501　2012/06

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

  61. 慢性腎臓病における線維化と腎性貧血を担う細胞の同定およびその制御法の開発

    高瀬昌幸, 浅田礼光, 中村仁, 小口綾貴子, 浅田三咲子, 鈴木教郎, 山村研一, 名越慈人, 芝田晋介, 深津敦司, 峯岸直子, 北徹, 木村剛, 岡野栄之, 山本雅之, 柳田素子

    日本腎臓学会誌　54　(3)　261-261　2012/04

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  62. 間葉系幹細胞から腎エリスロポエチン産生細胞への分化誘導 (平成23年度研究奨励金受領報告) -- (間葉系幹細胞研究の新展開)

    鈴木 教郎

    東京生化学研究会助成研究報告集　27　115-119　2012

    Publisher: 東京生化学研究会

    ISSN： 1345-4927

  63. 胎仔期神経細胞,神経堤細胞によるエリスロポエチン産生

    平野育生, 鈴木教郎, PAN Xiaoqing, 山崎瞬, 峯岸直子, 山本雅之

    生化学　84回　3T14a-3　2011/09

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

  64. エリスロポエチン欠損マウスの部分レスキューによる遺伝性超貧血マウスの樹立

    山嵜瞬, 峯岸直子, 鈴木教郎, 山本雅之

    生化学　84回　3T16p-17　2011/09

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

  65. 慢性腎臓病における線維化と腎性貧血を担う細胞の同定およびその制御法の開発

    高瀬昌幸, 浅田礼光, 中村仁, 小口綾貴子, 浅田三咲子, 鈴木教郎, 山村研一, 名越慈人, 芝田晋介, NAGESWARA Tata Rao, JOERG HansFehling, 深津敦司, 峯岸直子, 北徹, 木村剛, 岡野栄之, 山本雅之, 柳田素子

    日本分子生物学会年会プログラム・要旨集(Web)　34th　WEB ONLY 2T13A-5　2011

  66. 転写因子GATA2によるG1サイクリン遺伝子発現の制御

    峯岸直子, 鈴木教郎, 鈴木未来子, 張替秀郎, 山本雅之

    生化学　83回・33回　2T8-4　2010/12

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

  67. 成獣における誘導的エリスロポエチン遺伝子破壊の造血に与える影響

    山嵜瞬, 峯岸直子, 鈴木教郎, 小原直, PAN Xiaoqing, 平野育生, 寺社下浩一, 本田紅里穂, 山本雅之

    生化学　83回・33回　1P-0304　2010/12

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

  68. 単離腎臓Erythropoietin産生細胞を用いたErythropoietin遺伝子制御機構の解明

    平野育生, PAN Xiaoqing, 鈴木教郎, 山崎瞬, 小原直, 峯岸直子, 山本雅之

    生化学　83回・33回　1P-0690　2010/12

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

  69. Rescue of Erythropoietin-Deficient Mice From Anemia by Complementation with BAC Transgene.

    Shun Yamazaki, Norio Suzuki, Naoshi Obara, Xiaoqing Pan, Ikuo Hirano, Kou-ichi Jishage, Kurisu Honda, Naoko Minegishi, Masayuki Yamamoto

    BLOOD　114　(22)　1397-1397　2009/11

    ISSN： 0006-4971

  70. Epo遺伝子欠失マウスのレスキューと条件付きEpo遺伝子破壊マウスの樹立

    山崎瞬, 鈴木教郎, 小原直, PAN Xiaoqing, 平野育生, 峯岸直子, 山本雅之

    生化学　82回　4T4p-11　2009/09

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

  71. エリスロポエチン産生細胞の同定と解析 (腎臓) Peer-reviewed

    潘小青, 鈴木教郎, 山本雅之

    腎臓　31　(2)　98-103　2008/11

    Publisher: (公財)日本腎臓財団

    ISSN： 0911-9752

  72. Erythropoietin in myoblast maintenance and muscle regeneration

    Yi Jia, Norio Suzuki, Masayuki Yamamoto, Max Gassmann, Constance Tom Noguchi

    FASEB JOURNAL　22　2008/04

    ISSN： 0892-6638

  73. Oxygen sensing and signaling of erythropoiesis Peer-reviewed

    今川 重彦, 小原 直, 鈴木 教郎

    The Cell　39　(13)　537-540　2007/11

    Publisher: ニューサイエンス社

    ISSN： 1346-7557

  74. 新規HIF阻害剤2-オキソグルタル酸投与による腫瘍血管新生抑制効果

    松本 健, 今川 重彦, 小原 直, 鈴木 教郎, 長澤 俊郎, 山本 雅之

    臨床血液　48　(9)　879-879　2007/09

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

    eISSN： 1882-0824

  75. Regulation of mouse Gatal gene expression in erythroid progenitors

    Yamamoto Masayuki, Suzuki Mikiko, Suzuki Norio, Shimizu Ritsuko

    BLOOD CELLS MOLECULES AND DISEASES　38　(2)　188　2007/03

    DOI： 10.1016/j.bcmd.2006.10.153 　

    ISSN： 1079-9796

  76. 酸素センシングと赤血球造血シグナル (細胞39)

    今川 重彦, 小原 直, 鈴木 教郎, 山本 雅之

    細胞39　537-540　2007/01

  77. Phenotypic changes of hematopoietic stem cells and stromal cells by aberrant expression of GATA-2; Possible role for the development of aplastic anemia.

    Yoko Okitsu, Hideo Harigae, Shinichiro Takahashi, Naoko Minegishi, Norio Suzuki, Junichi Kameoka, Masayuki Yamamoto, Takeshi Sasaki

    BLOOD　108　(11)　378A-378A　2006/11

    ISSN： 0006-4971

  78. 2-オキソグルタル酸投与による腫瘍血管新生の抑制

    松本 健, 今川 重彦, 小原 直, 鈴木 教郎, 長澤 俊郎, 山本 雅之

    日本血栓止血学会誌　17　(5)　584-584　2006/10

    Publisher: (一社)日本血栓止血学会

    ISSN： 0915-7441

    eISSN： 1880-8808

  79. 2-オキソグルタル酸投与による腫瘍血管新生抑制効果

    松本 健, 今川 重彦, 小原 直, 鈴木 教郎, 長澤 俊郎, 山本 雅之

    臨床血液　47　(9)　1237-1237　2006/09

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

    eISSN： 1882-0824

  80. Caffeineとtaurineの併用による持久力および乳酸に及ぼす効果 Peer-reviewed

    今川 貴彦, 松本 健, 小原 直, 鈴木 教郎, 山本 雅之, 今川 重彦

    臨床スポーツ医学　23　(2)　207-210　2006/02

    Publisher: (株)文光堂

    ISSN： 0289-3339

  81. Essential role and regulatory mechanism of the erythropoietin gene in the liver.

    N Suzuki, N Obara, KB Kim, XQ Pan, KI Jishage, S Imagawa, M Yamamoto

    BLOOD　106　(11)　878A-878A　2005/11

    ISSN： 0006-4971

  82. GATA motifs regulate early hematopoietic lineage-specific expression of the Gata2 gene (vol 25, pg 7005, 2005)

    M Kobayashi-Osaki, O Ohneda, N Suzuki, N Minegishi, T Yokomizo, S Takahashi, KC Lim, JD Engel, M Yamamoto

    MOLECULAR AND CELLULAR BIOLOGY　25　(22)　10202-10202　2005/11

    DOI： 10.1128/MCB.25.22.10202.2005 　

    ISSN： 0270-7306

  83. 2-oxoglutarate down-regulates expression of vascular endothelial growth factor and erythropoietin through decreasing hypoxia inducible factor-1 alpha and inhibits angiogenesis.

    S Imagawa, K Matsumoto, N Obara, N Suzuki, T Nagasawa, M Yamamoto

    BLOOD　106　(11)　69B-69B　2005/11

    ISSN： 0006-4971

  84. GATA motif on the erythropoietin gene promoter is essential for repression of ectopic constitutive erythropoietin production.

    N Obara, N Suzuki, K Ki-Bom, S Imagawa, T Nagasawa, M Yamamoto

    BLOOD　106　(11)　878A-878A　2005/11

    ISSN： 0006-4971

  85. 転写因子c-Mybによる巨核球系造血制御機構の解明

    向井 陽美, 本橋 ほづみ, 鈴木 教郎, 長澤 俊郎, 山本 雅之

    日本血液学会・日本臨床血液学会総会プログラム・抄録集　67回・47回　745-745　2005/09

    Publisher: 日本臨床血液学会

  86. 2-oxoglutarate投与による抗腫瘍血管新生療法への試み

    松本 健, 今川 重彦, 小原 直, 鈴木 教郎, 長澤 俊郎, 山本 雅之

    日本血液学会・日本臨床血液学会総会プログラム・抄録集　67回・47回　840-840　2005/09

    Publisher: 日本臨床血液学会

  87. GATA阻害・HIF-1活性薬(K-11706)による持久力増強効果

    今川 重彦, 松本 健, 小原 直, 鈴木 教郎, 長澤 俊郎, 山本 雅之

    日本臨床スポーツ医学会誌　13　(4)　S97-S97　2005/09

    Publisher: (一社)日本臨床スポーツ医学会

    ISSN： 1346-4159

  88. ユビキチン・プロテアソーム経路を介したGATA-2の迅速な代謝回転 (日本血液学会・日本臨床血液学会総会プログラム・抄録集)

    峯岸直子, 鈴木教郎, 川谷幸恵, 清水律子, 山本雅之

    日本血液学会・日本臨床血液学会総会プログラム・抄録集　67回・47回　749-749　2005/09

    Publisher: 日本臨床血液学会

  89. GATA阻害薬・HIF-1活性薬(K-11706)による持久力増強効果 Peer-reviewed

    今川 重彦, 松本 健, 長澤 俊郎, 土肥 武, 鈴木 教郎, 山本 雅之

    臨床スポーツ医学　22　(8)　1049-1052　2005/08

    Publisher: (株)文光堂

    ISSN： 0289-3339

  90. Perturbation of hematopoiesis as a consequence of transgene insertion into the proximity of c-myb gene.

    HY Mukai, H Motohashi, N Suzuki, O Ohneda, T Nagasawa, M Yamamoto

    BLOOD CELLS MOLECULES AND DISEASES　34　(2)　108-108　2005/03

    ISSN： 1079-9796

  91. Two novel erythroid progenitor fractions expressing GATA-1.

    N Suzuki, O Ohneda, N Obara, S Imagawa, M Yamamoto

    BLOOD CELLS MOLECULES AND DISEASES　34　(2)　124-125　2005/03

    ISSN： 1079-9796

  92. Fine regulation of GATA-1 and GATA-2 gene expression in vivo hematopoiesis.

    M Yamamoto, N Suzuki, O Ohneda, S Takahashi, JD Engel

    BLOOD CELLS MOLECULES AND DISEASES　34　(2)　132-132　2005/03

    ISSN： 1079-9796

  93. Ubiquitin-proteasome-dependent degradation of GATA-2 and its contribution to the UV-C-induced down-regulation

    N Minegishi, N Suzuki, Y Kawatani, M Yamamoto

    BLOOD　104　(11)　133B-133B　2004/11

    ISSN： 0006-4971

  94. GATA結合活性阻害・HIF-1結合活性亢進薬(K-11706)の経口投与による慢性貧血改善の試み

    今川 重彦, 松本 健, 小原 直, 鈴木 教郎, 高橋 智, 長澤 俊郎, 山本 雅之

    日本血液学会・日本臨床血液学会総会プログラム・抄録集　66回・46回　874-874　2004/09

    Publisher: 日本臨床血液学会

  95. プロテアソーム依存性分解系を介したGATA‐2蛋白質の迅速な代謝回転

    峯岸直子, 鈴木教郎, 川谷幸恵, 山本雅之

    日本分子生物学会年会プログラム・講演要旨集　26th　488　2003/11/25

  96. A novel GATA-specific inhibitor (GSI) rescues anemia of chronic disease by oral administration.

    S Imagawa, Y Nakano, N Obara, N Suzuki, T Nagasawa, M Yamamoto

    BLOOD　102　(11)　510A-510A　2003/11

    ISSN： 0006-4971

  97. 化学的二量体化物質による人工的赤血球造血制御

    向井 陽美, 鈴木 教郎, 大根田 修, 長澤 俊郎, 山本 雅之

    臨床血液　44　(8)　714-714　2003/08

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

    eISSN： 1882-0824

  98. 新規GATA特異的阻害薬の経口投与による慢性貧血改善の試み

    中野 陽子, 今川 重彦, 小原 直, 鈴木 教郎, 長澤 俊郎, 山本 雅之

    臨床血液　44　(8)　714-714　2003/08

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

    eISSN： 1882-0824

  99. 機能的レスキュー法を用いた個体レベルでの血球系GATA因子群の分子機能比較

    小原 直, 鈴木 教郎, 大根田 修, 高橋 智, 今川 重彦, 長澤 俊郎, 山本 雅之

    臨床血液　44　(8)　779-779　2003/08

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

    eISSN： 1882-0824

  100. Transgenic expression of erythropoietin receptor (EPOR) under the GATA-1 gene regulatory domain rescued EPOR knockout mouse from lethality.

    N Suzuki, O Ohneda, HY Mukai, S Imagawa, S Takahashi, M Yamamoto

    BLOOD CELLS MOLECULES AND DISEASES　31　(1)　166-166　2003/07

    ISSN： 1079-9796

  101. A constitutively active aryl hydrocarbon receptor induces growth inhibition by cell cycle arrest and apoptosis in Jurkat T cells.

    T Ito, S Tsukumo, M Yamamoto, H Motohashi, N Suzuki, Y Fujii-Kuriyama, J Mimura, C Tohyama, K Nohara

    TOXICOLOGICAL SCIENCES　72　367-367　2003/03

    ISSN： 1096-6080

  102. GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1 beta, TNF-alpha or L-NMMA.

    S Imagawa, Y Nakano, N Obara, N Suzuki, T Doi, T Kodama, M Yamamoto, T Nagasawa

    BLOOD　100　(11)　657A-657A　2002/11

    ISSN： 0006-4971

  103. 新規エリスロポエチン発現促進薬(K-7174) 腎性貧血への試み

    今川 重彦, 土肥 武, 小原 直, 中野 陽子, 樋口 正人, 鈴木 教郎, 山本 雅之, 長澤 俊郎

    臨床血液　43　(8)　88-88　2002/08

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

    eISSN： 1882-0824

  104. カドミウムによるエリスロポエチン遺伝子発現抑制機序

    小原 直, 今川 重彦, 中野 陽子, 樋口 正人, 鈴木 教郎, 山本 雅之, 長澤 俊郎

    臨床血液　43　(8)　175-175　2002/08

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

    eISSN： 1882-0824

  105. 2-oxoglutarateによるVEGF・Epo産生抑制作用

    中野 陽子, 今川 重彦, 小原 直, 樋口 正人, 鈴木 教郎, 山本 雅之, 長澤 俊郎

    臨床血液　43　(8)　175-175　2002/08

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

    eISSN： 1882-0824

  106. GATA-1-GFPトランスジェニックマウスを用いた赤芽球前駆細胞の解析

    鈴木 教郎, 諏訪部 徳芳, 小原 直, 潘 小青, 高橋 智, 大根田 修, 山本 雅之

    生化学　74　(8)　805-805　2002/08

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

    eISSN： 2189-0544

  107. C.elegansの細胞移動変異体mig-22の解析

    鈴木 教郎, 西脇 清二

    日本発生生物学会大会講演要旨集　35回　208-208　2002/05

    Publisher: 日本発生生物学会

  108. Elevation of vascular endothelial growth factor in patients with obstructive sleep apnea-hypopnea syndrome is not due to increased platelet counts - Response

    S Imagawa, Y Yamaguchi, M Higuchi, T Neichi, Y Hasegawa, H Mukai, N Suzuki, M Yamamoto, T Nagasawa

    BLOOD　99　(1)　393-394　2002/01

    ISSN： 0006-4971

  109. GATA-2 is a negative regulator of erythropoietin gene expression in mouse.

    S Imagawa, N Suzuki, K Ohmine, N Obara, M Yamamoto, T Nagasawa

    BLOOD　98　(11)　127B-127B　2001/11

    ISSN： 0006-4971

  110. 造血組織の個体発生における転写因子の発現と機能の動的解析

    峯岸直子, 鈴木教郎, 山本雅之

    Cytom Res　11　(Suppl.)　20-20　2001/06

    Publisher: (一社)日本サイトメトリー学会

    ISSN： 0916-6920

    eISSN： 2424-0664

  111. Non-hematopoietic expression of mouse EpoR is inessential for survival, development, and reproduction.

    N Suzuki, H Mukai, M Higuchi, S Takahashi, S Imagawa, M Yamamoto

    BLOOD　96　(11)　84A-84A　2000/11

    ISSN： 0006-4971

  112. L-arginine rescues decreased erythropoietin gene expression by stimulating GATA-2 with N-G-monomethyl L-arginine.

    S Imagawa, T Tarumoto, H Mukai, M Higuchi, N Imai, N Suzuki, M Yamamoto, K Ozawa, T Nagasawa

    BLOOD　96　(11)　132B-132B　2000/11

    ISSN： 0006-4971

  113. Regulation of mouse GATA-1 and GATA-2 genes.

    M Yamamoto, N Minegishi, R Shimizu, N Suzuki, S Takahashi

    BLOOD CELLS MOLECULES AND DISEASES　26　(5)　507-507　2000/10

    ISSN： 1079-9796

  114. エリスロポエチン受容体欠損マウスの赤血球特異的トランスジーンレスキュー

    鈴木 教郎, 樋口 正人, 高橋 智, 山本 雅之

    生化学　72　(8)　1091-1091　2000/08

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

  115. 造血前駆細胞におけるGATA‐2発現のGFPノックイン法を用いた解析

    鈴木教郎, 峯岸直子, 中島修, 高橋智, 山本雅之

    日本分子生物学会年会プログラム・講演要旨集　22nd　597　1999/11/22

  116. 造血幹細胞で働く転写制御機構と血液細胞の分化方向性の制御

    山本雅之, 峯岸直子, 鈴木教郎, 西村滋子, 諏訪部徳芳, 高橋智

    日本分子生物学会年会プログラム・講演要旨集　22nd　196　1999/11/22

  117. Fine tuning of the GATA-2 expression during hematopoietic cell development in aorta-gonads and mesonephros region.

    N Minegishi, N Suzuki, M Yamamoto

    BLOOD　94　(10)　470A-470A　1999/11

    ISSN： 0006-4971

  118. 腎性貧血の機序解明 L-NMMAによるエリスロポエチン遺伝子発現抑制

    樽本 高壽, 大嶺 護, 小澤 敬也, 鈴木 教郎, 山本 雅之, 樋口 正人, 今井 信雄, 今川 重彦

    生化学　71　(8)　814-814　1999/08

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

  119. 転写因子GATA-2の胎児造血組織における発現とその転写調節機構

    峯岸 直子, 潘 小青, 太田 潤, 山際 浩徳, 鈴木 教郎, 大崎 牧, 山本 雅之

    生化学　71　(8)　947-947　1999/08

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

  120. 転写調節不均衡による貧血の発生機序

    樽本 高壽, 今川 重彦, 大嶺 謙, 永井 正, 樋口 正人, 今井 信雄, 鈴木 教郎, 山本 雅之, 小澤 敬也

    International Journal of Hematology　69　(Suppl.1)　197-197　1999/04

    Publisher: (一社)日本血液学会

    ISSN： 0925-5710

    eISSN： 1865-3774

  121. Novel mechanism of the renal anemia : N^G-monomethyl L-arginine inhibits erythropoietin gene expression

    TARUMOTO Takahisa, IMAGAWA Shigehiko, OHMINE Ken, NAGAI Tadashi, SUZUKI Norio, YAMAMOTO Masayuki, HIGUCHI Masato, IMAI Nobuo, OZAWA Keiya

    日本分子生物学会年会プログラム・講演要旨集　21　417-417　1998/12/01

  122. Structure and activity of GATA-2 gene distal (IS) promoter.

    N Minegishi, Pan, X, H Yamagiwa, J Ohta, S Kawauchi, N Suzuki, S Takahashi, M Yamamoto

    BLOOD　92　(10)　570A-570A　1998/11

    ISSN： 0006-4971

  123. 転写調節 L-NMMAによるエリスロポエチン遺伝子発現抑制が腎性貧血の一因である

    樽本 高寿, 大嶺 謙, 小澤 敬也, 鈴木 教郎, 山本 雅之, 樋口 正人, 今井 信雄, 今川 重彦

    生化学　70　(8)　783-783　1998/08

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

Show all ︎Show first 5

Research Projects 14

  1. Elucidation of renoprotective effects by pharmacological intervention into oxygen metabolism, using living renal cells from urine of diabetic kidney disease patients

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Fund for the Promotion of Joint International Research (International Collaborative Research)

    Institution: Tohoku University

    2023/09/08 - 2026/03/31

  2. Diversity of fibroblasts brings versatility of organ interstitia

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2021/04/01 - 2025/03/31

  3. 腎臓の赤血球増殖因子産生細胞における血圧調節系と造血制御系のクロストーク（鈴木教郎） Competitive

    鈴木教郎

    System: 科学研究費補助金 挑戦的研究（萌芽）

    2017/04 - 2019/03

  4. 赤血球増殖因子の造血外機能の解明 Competitive

    鈴木教郎

    System: 科学研究費補助金 基盤研究(B) 一般

    2015/04 - 2019/03

  5. 低酸素ストレスに対するシステミックな生体応答機構の解明 Competitive

    山本雅之

    System: 科学研究費補助金 新学術領域研究 計画研究

    2014/07 - 2019/03

  6. Regulation of Erythropoietin production and its roles on adult hematopoiesis

    MINEGISHI Naoko, SUZUKI Mikiko, HIRANO Ikuo, SUZUKI Norio, SOUMA Tomokazu, YAMAZAKI Shun

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2012/04/01 - 2016/03/31

    More details Close

    Erythropoietin, secreted from adult kidney, is essential for erythropoiesis. We made ISAM (Inherited Super Anemic Mice), which exhibited Epo-deficient-anemia in their adulthood. We found the significantly decreased number of proerythroblasts and basophilic erythroblasts in their bone marrow, and several downstream-genes of Epo signals in bone marrow cells. Epo producing cells of ISAM were demonstrated as the cells expressing green fluorescence, among cortical fibroblasts in adult kidneys, and also in the portion of embryonic neural cells and neural crest cells. In the experimental fibrotic kidneys, Epo-producing cells transformed into myofibroblasts and halted Epo production. These changes were reversible. We have an impression that the inhibition of inflammatory signals might be a novel therapeutic strategy for renal fibrosis and renal anemia.

  7. 低酸素環境での代謝リプログラミングを促す転写制御機構の解明 Competitive

    鈴木教郎

    System: 科学研究費補助金 新学術領域研究 公募研究

    2014/04 - 2016/03

  8. 慢性低酸素に対する生体恒常性維持の分子機構 Competitive

    鈴木教郎

    System: 科学研究費補助金 挑戦的萌芽研究

    2013/04 - 2016/03

  9. Roles of stress-responsive transcription factors in health and disease

    YAMAMOTO Masayuki, KATSUOKA Fumiki, URUNO Akira, SUZUKI Norio

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Tohoku University

    2012/04/01 - 2015/03/31

    More details Close

    Transcription factor Nrf2 regulates a broad cytoprotective response to environmental stresses through induction of cellular defense enzymes. Keap1 is an adaptor protein for cullin3-based ubiquitin E3 ligase and negatively regulates Nrf2. This notion has been best demonstrated in animal models, showing that Nrf2-null mice are sensitive to a wide variety of electrophiles and reactive oxygen species (ROS). Keap1 possesses reactive cysteine residues that act as sensors for electrophilic and oxidative stresses. We have verified this model through structure biology, mouse/zebrafish genetics, and human cancer analyses. Elevated expression of NRF2 target genes confers advantages on the growth of cancer cells through the metabolic reprogramming. Thus, the Keap1-Nrf2 system opens a new avenue to the understanding of the signal transduction and regulatory processes underlying the stress response and cancer progression.

  10. 間欠的低酸素環境下での代謝系を介した転写制御機構の解明 Competitive

    鈴木教郎

    System: 科学研究費補助金 新学術領域研究 公募研究

    2012/04 - 2014/03

  11. 間葉系幹細胞から腎エリスロポエチン産生細胞への分化誘導 Competitive

    鈴木教郎

    Offer Organization: 東京生化学研究会

    2012/02 - 2014/03

  12. エリスロポエチン遺伝子におけるクロマチン制御系 Competitive

    鈴木教郎

    Offer Organization: JST

    System: 戦略的創造研究推進事業 研究シーズ探索プロイグラム

    2011/07 - 2012/03

  13. Molecular Mechanisms of Adaptive Responses to Food and Oxygen

    YAMAMOTO Masayuki, KATSUOKA Fumiki, MINEGISHI Naoko, MOTOHASHI Hozumi, KUROKAWA Hirofumi, SUZUKI Norio, MORIGUCHI Takashi, SUZUKI Takafumi, TAGUCHI Keiko

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Creative Scientific Research

    Institution: Tohoku University

    2007 - 2011

    More details Close

    Environmental stress response system allows organisms to keep cellular homeostasis. In this study, weexamined Keap1-Nrf2-mediated oxidative and xenobiotic defense system, and identified novel molecular mechanisms for stress-sensing system and their association with diseases. We alsoidentified diverse and elaborate gene regulatory mechanisms in response to hypoxic stressthrough the comprehensive analysis of erythropoietin gene regulatory regions.

  14. Transcriptional regulation Competitive

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