Details of the Researcher

PHOTO

Toru Ogawa
Section
Tohoku University Hospital
Job title
Professor
Degree

  • Ph.D (Tohoku University)

Research History 7

  • 2024/11 - Present
    Tohoku University Hospital / Tohoku University Graduate School of Dentistry　Comprehensive Dentistry　Professor

  • 2014/04 - 2024/10
    東北大学大学院歯学研究科 准教授

  • 2011/04 - 2014/03
    東北大学病院　咬合回復科　講師

  • 2012/09 - 2013/03
    University of Sydney　Jaw Function and Orofacial Pain Research Unit, Faculty of Dentistry, Centre for Sleep Health and Research, Department of Respiratory Medicine　Endeavour Research Fellowships for Japan

  • 2003/11 - 2011/03
    東北大学病院　咬合回復科　助教

  • 2008/01 - 2010/07
    Katholieke Universiteit Leuven　Department of Prosthetic Dentistry/ BIOMAT Research Group　Visiting Professor

  • 2003/04 - 2003/10
    東北大学病院 医員

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Education 2

  • 東北大学大学院歯学研究科

    1999/04 - 2003/03

  • 東北大学 歯学部

    1993/04 - 1999/03

Committee Memberships 18

  • 日本顎口腔機能学会　常任理事 （ガイドライン、顎口腔機能セミナー担当）

    2024/04 - Present

  • 日本睡眠歯科学会　教育委員会

    2023/08 - Present

  • 日本睡眠歯科学会　評議員

    2023/08 - Present

  • 日本口腔顔面痛学会　学会誌編集委員会 委員

    2022/04 - Present

  • 日本口腔顔面痛学会　渉外委員会 オブザーバー

    2022/04 - Present

  • 日本補綴歯科学会　渉外委員会 委員

    2022/04 - Present

  • 日本補綴歯科学会　代議員

    2021/04 - Present

  • 日本口腔顔面痛学会　e-learning検討部会 委員

    2020/04 - Present

  • 日本口腔顔面痛学会　ポスター賞推薦委員会 委員

    2020/04 - Present

  • 日本口腔顔面痛学会　医療保険委員会 委員

    2018/04 - Present

  • 日本顎口腔機能学会　常任理事 （倫理審査担当）

    2022/04 - 2024/03

  • 日本補綴歯科学会　修練医・認定医・専門医認定委員会 委員

    2020/04 - 2022/03

  • 日本口腔顔面痛学会　IASP教育システム開発プロジェクト委員会 委員

    2019/09 - 2022/03

  • 日本顎口腔機能学会　評議員

    2008/04 - 2022/03

  • 東北大学歯学会　幹事

    2018/01 - 2020/12

  • 日本補綴歯科学会　研究企画推進委員会 委員

    2018/04 - 2020/03

  • 日本顎顔面補綴学会　COI委員会

    2019 - 2020

  • 日本補綴歯科学会　社会連携委員会 幹事

    2016/04 - 2018/03

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Professional Memberships 17

  • 日本総合歯科学会

  • 日本咀嚼学会

  • 日本義歯ケア学会

  • 日本歯科医学教育学会

  • 日本老年歯科医学会

  • International College of Prosthodontists

  • International Association for Dental Research

  • 日本顎関節学会

  • 日本口腔インプラント学会

  • 日本口腔顔面痛学会

  • 日本睡眠学会

  • 日本顎顔面補綴歯科学会

  • 日本スポーツ歯科医学会

  • 日本睡眠歯科学会

  • 日本補綴歯科学会

  • 日本顎口腔機能学会(2005/04-2007/03 庶務幹事)

  • THE JAPAN ACADEMY OF OROFACIAL PAIN(2005/04-2007/03 会長幹事)

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Research Areas 1

  • Life sciences / Oral medicine (pathology) /

Awards 12

  1. HIMAWAN AWARD

    2024/07　The 14th Biennial Congress of the Asian Academy of Prosthodontics (AAP)　PCA-based kinematic classification of mandibular movements from TMD patients

  2. 優秀ポスター賞 デンツプライシロナ賞

    2024/07　日本補綴歯科学会第133回学術大会　拡散テンソル画像を応用した内・外側翼突筋筋線維走行の三次元解析

  3. 課題口演優秀賞

    2024/07　日本補綴歯科学会第133回学術大会　高齢者の口腔・認知の両機能を向上させる訓練方法：二重盲検RCTによる効果検証

  4. 優秀口演賞

    2024/02　第16回日本義歯ケア学会学術大会　医用材料応用へ向けた100％セルロースナノファイバーの生物学的安全性に関する検討

  5. 優秀ポスター賞

    2023/03　令和４年度生体医歯工学共同研究拠点成果報告会　Shear Wave Elastographyによる慢性・急性疲労を模擬した等尺性筋収縮前後の咬筋弾性の評価

  6. OUTSTANDING POSTER AWARD

    2022/11　2022 TU-HKU-FJMU Symposium on Oral Health Sciences

  7. デンツプライシロナ賞

    2018　第48回日本口腔インプラント学会学術大会　ラット脛骨インプラントにおける低強度高周波振動刺激と低出力超音波パルスのインプラント周囲骨形成促進効果に関する検討

  8. Poster Awards

    2016　China-Japan-Korea Dental Science Symposium　Effect of mandibular advancement splint treatment on tongue and soft palate shape change in obstructive sleep apnea.

  9. Japan Prosthodontic Society

    2014　Stimulation of titanium implant osseointegration through high frequency vibration loading is enhanced when applied at high acceleration.

  10. 課題口演賞

    2011　日本補綴歯科学会第120回記念学術大会　低強度・高周波振動刺激によるインプラント周囲骨の骨形成活性化に関する研究

  11. Young Investigator Prize 1st place

    2010/07　88th IADR meeting, Implantology Research Group　Effect of whole body vibration loading on peri-implant bone healing.

  12. 特定推進研究優秀論文賞

    2007/05/20　日本補綴歯科学会　Functional properties and regional differences of human masseter motor units related to three-dimensional bite force.

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Papers 95

  1. Anomaly detection of screw loosening of different implant-abutment connection designs using resonance frequency analysis: An in vitro study. International-journal Peer-reviewed

    Sammour SR, Naito H., Shigemitsu R., Xie Z., Kimoto T., Sasaki K., Yoda N., Ogawa T.

    The Journal of prosthetic dentistry　2026/01/02

    DOI： 10.1016/j.prosdent.2025.12.007 　

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    STATEMENT OF PROBLEM: Screw loosening is a common mechanical complication in implant-supported restorations, yet early detection remains challenging because of the lack of noninvasive, quantitative assessment tools. PURPOSE: This in vitro study aimed to evaluate the ability of resonance frequency analysis (RFA) combined with machine learning techniques to detect screw loosening in 3 implant-abutment connection designs: conical, internal tri-channel, and external hexagonal. MATERIAL AND METHODS: Three connection types were tested using 6 implants inserted into mandibular jaw models. RFA was conducted using a triaxial accelerometer under 7 loosening conditions with the frequency responses in the x, y, and z directions being recorded. Supervised learning (random forest) was used for binary (intact versus abnormal) and multiclass (7 classes) classification. Unsupervised learning was used to detect anomalies. RESULTS: The RFA revealed unique vibrational profiles for each connection design. The random forest classifier achieved 100% accuracy in binary classification and 83% to 92% in multiclass classification. Feature importance analysis highlighted the relevance of the triaxial vibration data. The convolutional autoencoder consistently identified screw loosening as early as 5 degrees. CONCLUSIONS: RFA combined with machine learning reliably detected screw loosening across various types of implant-abutment connections. This method offers a noninvasive, quantitative tool for the early detection of mechanical complications in implant dentistry.

  2. Evaluation of bone regenerative potential of sticky bone combined with DPBM and APRF in a rabbit tibial model: an in vivo study. International-journal Peer-reviewed

    Shu Y., Wu L., Zheng W., Qi S., Yang Y., Chen Y., Zhu H., Ogawa T., Lv C., Tsoi JKH, Zheng S.

    BMC oral health　25　(1)　1688-1688　2025/10/28

    DOI： 10.1186/s12903-025-07085-w 　

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    BACKGROUND: Bone regeneration often relies on biomaterials to promote osteogenesis and modulate inflammation. Growth-factor-rich matrices and xenogeneic bone scaffolds have been reported to influence bone formation, vascularisation, and immune responses in vivo. This study therefore compared four biomaterials for their bone-regenerative potential in a rabbit non-critical tibial defect model: (1)Deproteinized porcine bone mineral (DPBM) (2)APRF (Advanced Platelet-Rich Fibrin) (3)Sticky Bone (STB, formed by combining DPBM and APRF) (4)Bovine collagen scaffolds (CS). METHODS: Thirty 15-week-old male New Zealand White rabbits were assigned to five groups: empty control (EC), DPBM, APRF, STB, and CS. Bilateral tibial defects (2.2 mm in diameter, 6 mm in depth) were filled with the respective materials and covered with porcine collagen membranes. Assessments at 2 and 6 weeks included micro-CT, histology, and immunohistochemistry (Runx2, ALP, CD31, TNF-α) to evaluate bone formation, vascularization, and inflammation. RESULTS: STB exhibited consistently greater new bone fill and a stronger trabecular framework, alongside elevated Runx2 and ALP levels, indicating enhanced osteogenic capacity. Concurrently, higher CD31 expression and lower TNF-α suggested improved vascularization and attenuated inflammation. By contrast, collagen alone showed limited osteoinduction, whereas APRF alone provided mild early bone promotion. Taken together, these findings highlight STB's enhanced bone-regenerative capacity. However, no statistically significant differences in new bone formation were observed between STB and DPBM at all time points. Notably, at the 2-week mark, STB demonstrated a more pronounced anti-inflammatory effect than DPBM, reflected by significantly lower TNF-α levels. CONCLUSIONS: STB demonstrated a pronounced capability for promoting bone formation and reducing inflammation, suggesting its potential as an effective biomaterial for clinical bone regeneration. Nonetheless, differences between STB and DPBM were not statistically significant at all time points, warranting further investigation into their comparative efficacy.

  3. Impact of implant abutment connection designs and cyclic loading on screw stability in dental implants: A systematic review and meta-analysis Peer-reviewed

    Sammour SR, Ziqi X., Ogawa T., Yoda N.

    The Journal of Prosthetic Dentistry　2025/10

    Publisher: Elsevier BV

    DOI： 10.1016/j.prosdent.2025.09.035 　

    ISSN： 0022-3913

  4. Development of a Digital Sialometry Device for Minor Salivary Glands with Enhanced Volume Range and Precision Peer-reviewed

    Gotoh S, Kachi H, Satoh-Kuriwada S, Otabe T, Hatakeyama T, Ogawa T, Iikubo M.

    Cureus.　in press.　2025/09

  5. Marginal and internal fit of zirconia crowns fabricated by advanced customized jetting and digital intraoral scanning: An in vitro study Peer-reviewed

    Liwei Wu, Jiayang Zhang, Toru Ogawa, Wanqian Zheng, Ke Cai, Yeting Yang, Sheng Zheng

    The Journal of Prosthetic Dentistry　134　(3)　759.e1-759.e7　2025/09

  6. Silver ions and bacteria as promoters of UV-A photocatalysis Peer-reviewed

    Taito Iwabuchi, Taichi Tenkumo, Takayuki Mokudai, Toru Ogawa, Keiichi Sasaki, Nobuhiro Yoda

    Journal of Photochemistry and Photobiology A: Chemistry　463　2025/06/01

    DOI： 10.1016/j.jphotochem.2025.116269 　

    ISSN： 1010-6030

  7. Enhanced peri-implantitis management through purple-LED irradiation coupled with silver ion application and calcium phosphate gene transfection carrier coating Peer-reviewed

    Iwabuchi T., Tenkumo T., Mokudai T., Takahashi M., Ogawa T., Sasaki K., Yoda N.

    Scientific Reports　15　(1)　13759　2025/04/21

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-025-96075-7 　

    eISSN： 2045-2322

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    Abstract The aim of this study was to investigate the bactericidal effect and recovery of biocompatibility of contaminated titanium surfaces using a combination treatment involving silver, copper, or iron ion application along with 400 nm purple-LED light irradiation. Additionally, the study sought to develop a functional calcium phosphate (CaP) coating treatment on titanium surfaces following disinfection, to promote re-osseointegration. A purple-LED emitting light at 400 nm was utilized to irradiate Staphylococcus aureus suspensions and biofilms in the presence of various concentrations of silver, copper, and iron solutions for 1 min. The bactericidal effect and electron spin resonance (ESR) spectrum were subsequently evaluated. Additionally, the hydrophilicity of the titanium surface and cell viability of MC3T3-E1 cells after combination treatment with silver ion was evaluated. Furthermore, a titanium surface coating with CaP gene transfection carrier containing plasmid DNA was developed using an electric current. The activity of hard tissue formation was then evaluated both in vitro and in vivo post-treatment. The bactericidal effect of the combination treatment with silver ions was attributed to the generation of hydroxyl radicals, whereas the effects from iron and copper treatments were not radical-mediated. The silver treatment significantly restored the hydrophilicity and cell affinity of the titanium surface. Moreover, CaP coating applied via an electric current (30 µA for 5 min) enhanced hard tissue formation activity on the titanium surface in both in vitro and in vivo settings. The combination treatment utilizing silver ions and purple-LED irradiation significantly enhanced bactericidal effects by generating high levels of hydroxyl radicals. Additionally, coating the titanium surface with functionalized CaP promoted early osseointegration, suggesting a promising strategy for improving implant outcomes.

  8. Accuracy assessment of three-dimensional abutment tooth data construction using swept-source optical coherence tomography. International-journal

    Mizuki Kakizawa, Hiroki Hihara, Takumi Ishikawa, Daisuke Oida, Makoto Tojo, Toru Ogawa, Kenta Shobara, Kuniyuki Izumita, Takayuki Harata, Hiroyasu Kanetaka, Nobuhiro Yoda, Masaki Hosoda, Keiichi Sasaki

    PloS one　20　(11)　e0333917　2025

    DOI： 10.1371/journal.pone.0333917 　

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    A limitation of widely used intraoral scanners (IOSs) is their inability to capture finish lines at the subgingival marginal area, as they only extract surface information. Swept-source optical coherence tomography (SS-OCT) captures high-speed, high-resolution cross-sectional images of soft and hard tissues. Integrating this technology can overcome clinical IOS limitations. Therefore, this study was conducted to fabricate crowns from three-dimensional images scanned with SS-OCT as a proof-of-principle for its application in IOSs and to evaluate fit accuracy. TRIOS3 was used for comparison, with both SS-OCT and TRIOS3 scanned three times, and crowns were fabricated using the same digital workflow. Internal gaps were measured using scanning electron microscopy, and marginal fit was evaluated via microscopy. Results showed that TRIOS3 had superior accuracy. SS-OCT can image solely in the occlusal direction, with accuracy decreasing at greater depths, which reduces precision around the margin. Additionally, SS-OCT lacks automatic correction of surface information in computer-aided design (CAD) software. To improve SS-OCT accuracy for abutment tooth measurements, automatic margin correction, improved CAD compatibility, and specialized probes for capturing tooth features are needed.

  9. Effectiveness of Fully Remote Practical Training in Dental Education: A Case Study Using Video Conferencing and Communication Tools for the Preparation of Removable Partial Dentures Peer-reviewed

    Lin Chih Ting, Tenkumo T., Shobara K., Yamaguchi H., Koide R., Ogawa T., Sasaki K., Yoda N.

    Jordan Journal of Dentistry　2025/01

  10. Effects of phototherapy in patients with idiopathic facial palsy: Scoping review. International-journal

    Keita Takizawa, Kana Ozasa, Akiko Shimada, Toru Ogawa, Takashi Iida, Yuka Oono, Keiichi Sasaki, Noboru Noma

    The Japanese dental science review　60　250-257　2024/12

    DOI： 10.1016/j.jdsr.2024.09.001 　

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    Phototherapy has emerged as a promising treatment for Bell's palsy, offering potential improvements in facial nerve function and overall well-being. In this study, we selected seven relevant studies involving 306 patients with subacute or acute Bell's palsy from PubMed, EMBASE, Web of Science, and Scopus before June 5, 2024. Low-level laser therapy (LLLT) efficacy for facial nerve paralysis was assessed in seven studies. Two studies lacked standard deviation data, precluding meta-analysis. Sunnybrook scores favored LLLT (mean difference [MD] = 17.42, 95 % confidence interval [CI]: 4.00-30.84, p = 0.011). However, Facial Disability Index results showed no significant difference (MD = 12.16, 95 % CI: -0.60 to 24.92, p = 0.061) between LLLT and control. LLLT, particularly with wavelengths of 830 or 850 nm administered over 6 weeks, may lead to beneficial outcomes. Combining LLLT with exercise therapy appears to be effective．LLLT demonstrates promise as a management option for Bell's palsy, potentially offering advantages over other treatments, particularly in patients with comorbidities, such as diabetes. Phototherapy devices currently used in Japan offer non-invasive treatment with minimal patient burden. The safety and therapeutic efficacy of these devices have been confirmed as a potential treatment for facial nerve paralysis.

  11. Kinematic classification of mandibular movements in patients with temporomandibular disorders based on PCA

    Computers in Biology and Medicine　2024/12

  12. Activities of the dorsolateral and medial prefrontal cortices during oral function training with cognitive training elements: a NIRS study. International-journal

    Masumi Abe, Rui Nouchi, Toru Ogawa, Naru Shiraishi, Hiroki Hihara, Keiichi Sasaki, Nobuhiro Yoda

    BMC oral health　24　(1)　1250-1250　2024/10/19

    DOI： 10.1186/s12903-024-05044-5 　

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    BACKGROUND: Cognitive function plays a crucial role in human life, and its maintenance and improvement are essential in both young and older adults. Since cognitive decline can be associated with oral function decline, preventing the decline in both cognitive and oral functions is an urgent social issue. Several training methods to improve each function have been proposed. Previous studies have indicated that greater brain activity during training is associated with increased benefits for cognitive function. Although adding cognitive function elements to oral function training may promote the activation of brain activity during oral function training, the effects have not been validated. The main purpose of this study is to develop a novel training program that combines oral function training with cognitive training, which is expected to activate key brain regions involved in oral and cognitive functions, such as the left dorsolateral prefrontal cortex (DLPFC) and right medial prefrontal cortex (mPFC). METHODS: Four types of training programs combining oral and cognitive training: PaTaKaRa × calculation, lip exercise × N-back, tongue exercise × inhibition, and tongue exercise × memory, were developed. Each program had seven levels of difficulty [level 0 (no cognitive load) and level 6 (maximum difficulty)]. Twelve healthy young adults participated in the study and were instructed to perform all four programs. Brain activity in the left DLPFC and right mPFC were measured during each training session using two-channel near-infrared spectroscopy (NIRS). RESULTS: No significant brain activity was observed during training at level 0. Brain activity in the left DLPFC was significantly increased at levels 1 and 2 and in the left DLPFC and right mPFC at level 6 during PaTaKaRa × calculation training. Brain activity in the left DLPFC was significantly increased at level 6 during tongue exercise × inhibition training. Brain activity in the left DLPFC and right mPFC was significantly increased at level 6 during lip exercise × N-back training. CONCLUSION: Oral function training did not significantly increase brain activity; nevertheless, oral function with cognitive training stimulated brain activity in the prefrontal cortex. TRIAL REGISTRATION: UMIN-CTR. ID: UMIN000039678. date: 06/03/2020.

  13. 歯科インプラント治療後の心理的変化に関する質問紙調査研究

    伊藤 明日香, 花渕 静, 小川 徹, 竹内 研時, 佐藤 由美子, 石井 京子, 小野寺 芽美, 渡部 千代, 佐々木 啓一, 依田 信裕

    日本歯科衛生学会雑誌　19　(1)　117-117　2024/08

    Publisher: 日本歯科衛生学会

    ISSN： 1884-5193

  14. A triple growth factor strategy for optimizing bone augmentation in mice Peer-reviewed

    Tenkumo T, Koide R, Ogawa T, Yamaguchi H, Suzuki S, Miyashita M, Nakamura K, Wang H, Yoda N, Sasaki K

    J Biomed Mater Res B Appl Biomater.　2024/06

  15. Difference in the electromyographic behavior of the masticatory and swallowing muscles during cued versus spontaneous swallowing Peer-reviewed

    Saito N, Ogawa T, Shiraishi N, Koide R, Komine H, Yokoyama M, Hanawa S, Sasaki K

    Dysphagia　39　(3)　398-406　2024/06

  16. 東北大学病院嚥下治療センター・歯科における筋萎縮性側索硬化症患者に対する介入の実態〜舌接触補助床の適用について〜 Peer-reviewed

    互野 亮, 白石 成, 千葉 智弘, 砂田 慶一, 小川 徹, 江草 宏, 小山 重人

    顎顔面補綴　2024/05

  17. Anomaly detection of retention loss in fixed partial dentures using resonance frequency analysis and machine learning: An in vitro study Peer-reviewed

    Sammour SR, Naito H, Kimoto T, Sasaki K, Ogawa T

    J Prosthodont Res.　68　(3)　510-519　2024/02

    DOI： 10.2186/jpr.JPR_D_23_00154. 　

  18. Development of triple-functionalized calcium phosphate nanoparticles as an advanced drug delivery system for bone tissue repair Peer-reviewed

    Tenkumo T, Kruse B, Kostka K, Sokolova V, Ogawa T, Yoda N, Prymak O, Suzuki O, Sasaki K, Epple M

    28　(25)　49-60　2023/11

    DOI： 10.1016/j.reth.2023.11.010. 　

  19. Impact of implant location on load distribution of implant-assisted removable partial dentures: a review of in vitro model and finite-element analysis studies. Peer-reviewed

    Ichikawa H, Yoda N, Ogawa T, Iwamoto M, Kawata T, Egusa H, Sasaki K

    Int J Implant Dent.　19　(9)　31　2023/09

  20. Effectiveness of exercise therapy on pain relief and jaw mobility in patients with pain-related temporomandibular disorders: A systematic review Peer-reviewed

    Shimada A, Ogawa T, Sammour S, Narihara T, Kinomura S, Koide R, Noma N, Sasaki K

    Frontiers in Oral Health-Oral and Maxillofacial Surgery　12　(4)　1170966　2023/07

  21. セルロースナノファイバーの生物学的安全性および吸水性に関する基礎的検討

    山田 有紀江, 小川 徹, 洪 光, 小出 理絵, 天雲 太一, 橋場 洋美, 稲用 亨, 謝 子き, 濱田 泰三, 佐々木 啓一

    日本補綴歯科学会誌　15　(特別号)　273-273　2023/05

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  22. 全部床義歯の咬合採得の工夫：両側臼歯部における４点接触装置の開発 Peer-reviewed

    山口栄二, 依田信裕, 小川徹, 佐々木啓一

    顎咬合学会誌　2023

  23. Introduction of tenomodulin by gene transfection vectors for rat bone tissue regeneration Peer-reviewed

    Wang H, Tenkumo T, Nemoto E, Kanda Y, Ogawa T, Sasaki K

    Regen Ther　12　(22)　99-108　2023/01

  24. Sensory neuromuscular electrical stimulation for dysphagia rehabilitation: A literature review Peer-reviewed

    Itt Assoratgoon, Naru Shiraishi, Ryo Tagaino, Toru Ogawa, Keiichi Sasaki

    Journal of Oral Rehabilitation　50　(2)　157-164　2023

    Publisher: Wiley

    DOI： 10.1111/joor.13391 　

    ISSN： 0305-182X

    eISSN： 1365-2842

  25. 口腔内スキャナを用いた下顎区域切除後の下顎偏位評価と影響因子の検討

    互野 亮, 佐藤 奈央子, 泉田 一賢, 畠山 高徳, 白石 成, 依田 信裕, 小川 徹, 小山 重人, 佐々木 啓一

    顎顔面補綴　45　(2)　62-63　2022/12

    Publisher: (一社)日本顎顔面補綴学会

    ISSN： 0389-4045

    eISSN： 2435-0389

  26. Factors that affect the fit of CAD/CAM inlay fabricated from a hybrid resin block Peer-reviewed

    Keisuke Asamizu, Toru Ogawa, Keiichi Sasaki

    Journal of Digital Dentistry　12　(2)　88-97　2022/09

  27. 舌がん患者の外科的治療術前・後における舌圧と口腔機能との関連

    互野 亮, 小山 重人, 白石 成, 泉田 一賢, 小宮山 貴将, 佐藤 奈央子, 小川 徹, 佐々木 啓一

    日本補綴歯科学会誌　14　(特別号)　284-284　2022/07

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  28. 舌がん患者の外科的治療術前・後における舌圧と口腔機能との関連

    互野 亮, 小山 重人, 白石 成, 泉田 一賢, 小宮山 貴将, 佐藤 奈央子, 小川 徹, 佐々木 啓一

    日本補綴歯科学会誌　14　(特別号)　284-284　2022/07

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  29. Prediction of mandibular advancement splint treatment response: moving toward individualized therapy for obstructive sleep apnea Peer-reviewed

    Toru Ogawa

    Sleep　45　(6)　2022/06/13

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/sleep/zsac072 　

    ISSN： 0161-8105

    eISSN： 1550-9109

  30. Morphological comparison of masseter muscle fibres in the mandibular rest and open positions using diffusion tensor imaging. International-journal Peer-reviewed

    Takehiko Sugano, Toru Ogawa, Nobuhiro Yoda, Teruo Hashimoto, Kenta Shobara, Kuniyasu Niizuma, Ryuta Kawashima, Keiichi Sasaki

    Journal of oral rehabilitation　49　(6)　608-615　2022/06

    DOI： 10.1111/joor.13319 　

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    BACKGROUND: The masseter muscle has a complicated multipennate internal structure and exhibits functional differentiation when performing various stomatognathic functions. It is important to understand the internal structural changes of the muscle during functioning to elucidate characteristic muscle disorders such as local myalgia. Diffusion tensor imaging (DTI) may be useful for investigating the internal structural features of muscle. OBJECTIVES: To evaluate the features of masseter muscle fibres in human participants using DTI fibre tractography, and to elucidate the structural differences in the masseter muscle between the mandibular rest and open positions. METHODS: Five healthy men (age 31 ± 7 years) underwent DTI and T1-weighted MRI of the right masseter muscle in the mandibular rest and open positions. MR images were used as a reference for muscle layer segmentation (superficial, intermediate, and deep). DTI fibre tractography of the masseter muscle was performed and the orientation of the DTI fibres was analysed in each layer using coordinates based on the Frankfurt horizontal plane. RESULTS: The DTI fibre orientation of the deep layer significantly changed between the mandibular rest and open positions in the frontal plane (p < 0.05, Wilcoxon rank sum test). However, no significant change was found in the superficial and intermediate layers. CONCLUSION: DTI fibre tractography confirmed regional differences in the orientation change of the masseter muscle fibres between different mandibular positions. The results may support the existence of functional partitioning inside the masseter muscle and suggest that DTI may be useful for the evaluation of muscle fibres in multipennate muscles.

  31. Resonance frequency analysis for evaluation of the connecting condition between fixed prostheses and their abutment teeth: An in vitro and finite element analysis study. International-journal Peer-reviewed

    Jingyu Qi, Makiko Miyashita, Toru Ogawa, Hideki Naito, Keiichi Sasaki

    The Journal of prosthetic dentistry　2022/04/28

    DOI： 10.1016/j.prosdent.2022.03.005 　

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    STATEMENT OF PROBLEM: Loss of retention is a clinical complication for fixed partial dentures (FPDs). However, a method sensitive enough to measure the early retention loss of FPDs is lacking. PURPOSE: The purpose of this in vitro and finite element analysis (FEA) study was to determine whether resonance frequency analysis (RFA) with a newly developed system can detect lack of FPD retention caused by cement loss. MATERIALS AND METHODS: Two evaluation methods were used: RFA of an in vitro model of a 3-unit FPD from the second premolar to the second molar and FEA by using a simplified model. The in vitro model was used to evaluate 4 connecting conditions: both crowns cemented, only the premolar crown cemented, only the molar crown cemented, and both crowns uncemented. Tapping stimulation (16 impulsive forces, 4 Hz) was directly applied to the buccal side of the second molar or the second premolar, and an attached 3D accelerometer sensor was used to record the resonance frequency (RF) of the tapped tooth. The amplitude, frequency, Q-value, and total area under the curve (AUC) of the RF values in the buccolingual direction were compared between connecting conditions. The FEA was done by using a simplified model of a 3-unit FPD with similar connecting conditions as the in vitro model study, and the RF amplitude and frequency of each tooth were calculated. Statistical evaluation included 1-way analysis of variance and the Tukey HSD test to compare the differences among each connecting condition under each parameter for measurement sites on the molar and the premolar, respectively (α=.05). RESULTS: For both the molar and premolar measurements in both the in vitro and FEA models, when the measurement site was on the uncemented tooth, the amplitude of RF-1 increased, the Q-value of RF-2 decreased, and the area under the curve increased (P<.05). CONCLUSIONS: The same 3 trends found between the measurement sites of the in vitro study and FEA indicated that RFA may be useful for detecting an FPD with loosening caused by cement loss, even partial cement loss.

  32. Application of Diffusion Tensor Imaging Fiber Tractography for Human Masseter Muscle. Peer-reviewed

    Takehiko Sugano, Nobuhiro Yoda, Toru Ogawa, Teruo Hashimoto, Kenta Shobara, Kuniyasu Niizuma, Ryuta Kawashima, Keiichi Sasaki

    The Tohoku journal of experimental medicine　256　(2)　151-160　2022/02

    DOI： 10.1620/tjem.256.151 　

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    Diffusion tensor imaging (DTI) has been used to indicate the direction of nerve and muscle fibers by using the characteristics that water molecules preferentially diffuse along the fibrous structure. However, DTI fiber tractography for multipennate muscles, such as the masseter muscle, is challenging due to a lack of data regarding the imaging parameters. This study aimed to determine the optimal DTI parameters for masseter muscle fiber tractography. A 27-year-old healthy man voluntarily underwent DTI and T1-weighted magnetic resonance imaging of the right masseter muscle. Four imaging parameter settings were created by combining the following parameters that particularly affect the signal-to-noise ratio: b-value, number of excitations (NEX), and number of motion probing gradient (MPG) directions. DTI fiber tractography was performed using specific software for each parameter setting. The length and orientation of the muscle fibers in each layer were calculated. As a result, the masseter muscle fibers of each layer were identified on DTI. Although the detected fiber length was affected significantly by the imaging parameters, the fiber orientation was insignificantly affected. The appropriate combination of the b-value, NEX, and the number of MPG directions for masseter muscle fiber tractography could be determined based on previously reported anatomical data of the masseter muscle fibers. DTI may enable the non-invasive evaluation of masseter muscle fiber length and orientation. Elucidation of the details of masseter muscle fiber orientation is useful in evaluating stomatognathic biomechanics and muscle disorders.

  33. Effectiveness of the Socket Shield Technique in Dental Implant: A Systematic Review. Peer-reviewed

    Toru Ogawa, Ratri M Sitalaksmi, Makiko Miyashita, Kenji Maekawa, Masahiro Ryu, Aya Kimura-Ono, Takeshi Suganuma, Takeshi Kikutani, Masanori Fujisawa, Katsushi Tamaki, Takuo Kuboki

    Journal of prosthodontic research　66　(1)　12-18　2022/01

    DOI： 10.2186/jpr.JPR_D_20_00054 　

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    PURPOSE: Dental implant therapy is a common clinical treatment for missing teeth. However, the esthetic result is not as satisfactory as expected in some cases, especially in the anterior maxillary area. Poor esthetic results are caused by inadequate preparation of the hard and soft tissues in this area before treatment. The socket shield technique may be an alternative for a desirable esthetic outcome in dental implant treatments. STUDY SELECTION: In the present systematic review, PubMed-Medline, Google Scholar, and ScienceDirect were searched for clinical studies published from January 2000 to December 2018. RESULTS: Twenty studies were included, comprising one randomized controlled trial, two cohort studies, 14 clinical human case reports, and three retrospective case series. In total, 288 patients treated with the socket shield technique with immediate implant placement and follow-up between 3-60 months after placement were included. A quality assessment showed that 12 of the 20 included studies were of good quality. Twenty-six of the 274 (9.5%) cases developed complications or adverse effects related to the socket shield technique. Most studies reported implant survival without the complications (90.5%); most of the cases that were followed up for more than 12 months after implant placement achieved a good esthetic appearance. The failure rate was low without the complications, although there were some failures due to failed implant osseointegration, socket shield mobility and infection, socket shield exposure, socket shield migration, and apical root resorption. CONCLUSIONS: The socket shield technique can be used in dental implant treatment, but it remains difficult to predict the long-term success of this technique until high-quality evidence becomes available.

  34. オクルーザルスプリントの使用により下顎偏位の改善を見た下顎骨片側離断後の再建症例

    互野 亮, 佐藤 奈央子, 泉田 一賢, 畠山 高徳, 白石 成, 小坂 萌, 依田 信裕, 小川 徹, 小山 重人, 佐々木 啓一

    顎顔面補綴　44　(2)　83-83　2021/12

    Publisher: (一社)日本顎顔面補綴学会

    ISSN： 0389-4045

    eISSN： 2435-0389

  35. Osteogenic effect of low-intensity pulsed ultrasound and whole-body vibration on peri-implant bone. An experimental in vivo study. International-journal Peer-reviewed

    Kenta Shobara, Toru Ogawa, Aya Shibamoto, Makiko Miyashita, Akiyo Ito, Ratri M Sitalaksmi

    Clinical oral implants research　32　(5)　641-650　2021/05

    DOI： 10.1111/clr.13738 　

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    OBJECTIVES: The aims of this study were (i) to compare the osteogenic impact of low-intensity pulsed ultrasound (LIPUS) and low-magnitude high-frequency (LMHF) loading achieved with whole-body vibration (WBV) on peri-implant bone healing and implant osseointegration in rat tibiae, and (ii) to examine their combined effect on these processes. MATERIAL AND METHODS: Titanium implants were inserted in the bilateral tibiae of 28 Wistar rats. Rats were randomly divided into four groups: LIPUS + WBV, LIPUS, WBV, and control. LIPUS was applied to the implant placement site for 20 min/day on 5 days/week (1.5 MHz and 30 mW/cm2 ). WBV was applied for 15 min/day on 5 days/week (50 Hz and 0.5 g). In the LIPUS + WBV group, both stimuli were applied under the same stimulation conditions as in the LIPUS and WBV groups. After 4 weeks of treatment, peri-implant bone healing and implant osseointegration were assessed using removal torque (RT) tests, micro-CT analyses of relative gray (RG) value, and histomorphometrical analyses of bone-to-implant contact (BIC) and peri-implant bone formation (BV/TV). RESULTS: The LIPUS + WBV group had significantly greater BIC than the WBV and control groups. Although there were no significant intergroup differences in RT, RG value, and BV/TV, these variables tended to be greater in the LIPUS + WBV group than the other groups. CONCLUSIONS: The combination of LIPUS and LMHF loading may promote osteogenic activity around the implant. However, further study of the stimulation conditions of LIPUS and LMHF loading is necessary to better understand the osteogenic effects and the relationship between the two stimuli.

  36. デジタル技術を用いて製作した閉塞性睡眠時無呼吸用口腔内装置の適合性および維持力に関する検討 Peer-reviewed

    相澤 なみき, 小川 徹, 原田 貴之, 佐々木 啓一

    睡眠口腔医学　7　(2)　78-87　2021/01

    Publisher: (NPO)日本睡眠歯科学会

    ISSN： 2188-6695

    eISSN： 2433-8524

  37. A comparison of colorimetric and visual methods for the assessment of masticatory performance with color-changeable chewing gum in older persons. International-journal Peer-reviewed

    Yoshihiro Kugimiya, Yutaka Watanabe, Maki Shirobe, Yoshiko Motohashi, Keiko Motokawa, Ayako Edahiro, Yuki Ohara, Masahiro Ryu, Kentaro Igarashi, Daichi Hoshino, Junko Nakajima, Takayuki Ueda, Yu Taniguchi, Toru Ogawa, Kenji Maekawa, Katsushi Tamaki, Takuo Kuboki, Akihiko Kitamura, Shoji Shinkai, Hirohiko Hirano

    Journal of dental sciences　16　(1)　380-388　2021/01

    DOI： 10.1016/j.jds.2020.08.010 　

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    Background/purpose: Color-changeable chewing gum is used for the evaluation of masticatory performance. However, it is currently unclear whether colorimetric and visual assessment methods yield consistent results. This study aimed to clarify the consistency between colorimetric and visual methods used for the evaluation of color changes in color-changeable chewing gum. Materials and methods: The sample comprised 644 older persons (mean age, 75.4 ± 6.4 years). The chewing gum was masticated 60 times at the participant's own chewing rate and then expectorated. The color of the chewing gum was evaluated with the ΔE values and a∗ values, measured using a colorimeter, and the 10 Color Shades (10CSh) and 5 Color Scales (5CSc), using visual evaluation. Spearman's correlation analysis was performed to examine the correlation between the results obtained by the four methods. The significance level was set at α = 0.05. Results: The ΔE values, a∗ values, 10CSh scores, and 5CSc scores were all significantly correlated. The highest correlation coefficient (0.979) was between the ΔE values and a∗ values. The lowest correlation coefficient (0.847) was between the a∗ values and 5CSc scores. Decreased masticatory performance was observed with increased age. Conclusion: Significant correlations were found for all four methods used in the assessment of masticatory performance with color-changeable chewing gum. While visually based assessments are valid, colorimetric methods are more sensitive to smaller changes in masticatory performance.

  38. Potential of pure cellulose nanofibers as a denture base material. Peer-reviewed

    Yukiko Yamazaki, Takao Ito, Toru Ogawa, Guang Hong, Yukie Yamada, Taizo Hamada, Keiichi Sasaki

    Journal of oral science　63　(1)　111-113　2020/12/23

    DOI： 10.2334/josnusd.20-0245 　

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    A study was conducted to evaluate the basic mechanical properties of a pure cellulose nanofiber (CNF) material in comparison with a commercial denture base material (polymethylmethacrylate [PMMA] acrylic resin). The working hypothesis was that CNFs have potential for use as denture base materials. Pure CNF specimens fabricated under various conditions were examined. The flexural strength (FS) and flexural modulus (FM) of the specimens were measured using the three-point bending test, and the morphologies of the fractured surfaces were examined using scanning electron microscopy. Addition of tricalcium phosphate to dehydrate the CNFs did not improve their FS or FM. Conversely, substitution with methanol effectively improved the dehydration process and significantly affected the mechanical properties of the CNFs. As the degree of CNF defibration increased, the physical properties of the specimens improved significantly. However, addition of CNFs to PMMA liquid to create CNF-reinforced PMMA did not improve the mechanical properties. Pure CNF specimens fabricated under particular conditions had higher FS and FM values than the control, suggesting that CNFs have potential as a "petroleum-free" alternative to acrylic resin denture base materials. Pure CNF would be potentially useful as a denture base material, and presumably applicable to computer-aided design/manufacture (CAD/CAM).

  39. Gene transfection achieved by utilizing antibacterial calcium phosphate nanoparticles for enhanced regenerative therapy. International-journal Peer-reviewed

    Chen Xiang, Taichi Tenkumo, Toru Ogawa, Yoshiaki Kanda, Keisuke Nakamura, Midori Shirato, Viktoriya Sokolova, Matthias Epple, Yuya Kamano, Hiroshi Egusa, Keiichi Sasaki

    Acta biomaterialia　119　375-389　2020/11/07

    DOI： 10.1016/j.actbio.2020.11.003 　

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    Protamine-coated multi-shell calcium phosphate (CaP) was developed as a non-viral vector for tissue regeneration therapy. CaP nanoparticles loaded with different amounts of plasmid DNA encoding bone morphogenetic protein 2 (BMP-2) and insulin-like growth factor 1 (IGF-1) were used to treat MC3T3E1 cells, and the yield of the released BMP-2 or IGF-1 was measured using ELISA 3 days later. Collagen scaffolds containing CaP nanoparticles were implanted into rat cranial bone defects, and BMP-2 and IGF-1 yields, bone formation, and bone mineral density enhancement were evaluated 28 days after gene transfer. The antibacterial effects of CaP nanoparticles against Streptococcus mutans and Aggregatibacter actinomycetemcomitans increased with an increase in the protamine dose, while they were lower for Staphylococcus aureus and Porphyromonas gingivalis. In the combination treatment with BMP-2 and IGF-1, the concentration ratio of BMP-2 and IGF-1 is an important factor affecting bone formation activity. The calcification activity and OCN mRNA of MC3T3E1 cells subjected to a BMP-2:IGF-1 concentration ratio of 1:4 was higher at 14 days. During gene transfection treatment, BMP-2 and IGF-1 were released simultaneously after gene transfer; the loaded dose of the plasmid DNA encoding IGF-1 did not impact the BMP-2 or IGF-1 yield or new bone formation ratio in vitro and in vivo. In conclusion, two growth factor-releasing systems were developed using an antibacterial gene transfer vector, and the relationship between the loaded plasmid DNA dose and resultant growth factor yield was determined in vitro and in vivo.

  40. Number of functional teeth more strongly predicts all-cause mortality than number of present teeth in Japanese older adults. Peer-reviewed

    Kenji Maekawa, Tomoko Ikeuchi, Shoji Shinkai, Hirohiko Hirano, Masahiro Ryu, Katsushi Tamaki, Hirofumi Yatani, Takuo Kuboki, Aya Kimura-Ono, Takeshi Kikutani, Takashi Suganuma, Yasunori Ayukawa, Tomoya Gonda, Toru Ogawa, Masanori Fujisawa, Shoichi Ishigaki, Yutaka Watanabe, Akihiko Kitamura, Yu Taniguchi, Yoshinori Fujiwara, Ayako Edahiro, Yuki Ohara, Junichi Furuya, Junko Nakajima, Kento Umeki, Kentaro Igarashi, Yasuhiro Horibe, Yoshihiro Kugimiya, Yasuhiko Kawai, Hideo Matsumura, Tetsuo Ichikawa, Shuji Ohkawa, Kazuyoshi Baba

    Geriatrics & gerontology international　22　(12)　1032-1039　2020/06

    DOI： 10.1111/ggi.14508 　

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    AIM: To examine the relationship between the number of present and functional teeth at baseline and future incidence of loss of independence. METHODS: Participants were community-dwelling older individuals who participated in a comprehensive geriatric health examination conducted in Kusatsu town, Japan, between 2009 and 2015. The primary endpoint was the incidence of loss of independence among participants, defined as the first certification of long-term care insurance in Japan. The numbers of present and functional teeth at baseline were determined via an oral examination. Demographics, clinical variables (e.g., history of chronic diseases and psychosocial factors), blood nutritional markers, physical functions, and perceived masticatory function were assessed. RESULTS: This study included 1121 individuals, and 205 individuals suffered from loss of independence during the follow-up period. Kaplan-Meier estimates of loss of independence for participants with smaller numbers of present and functional teeth were significantly greater than for those with larger numbers of teeth. Cox proportional hazard analyses indicated that a smaller number of present teeth was not a significant risk factor after adjusting for demographic characteristics. However, the number of functional teeth was a significant risk factor after the adjustment (hazard ratio: 1.975 [1.168-3.340]). Additionally, higher hazard ratios were observed in other adjusted models, but they were not statistically significant. CONCLUSIONS: The number of functional teeth may be more closely related to the future incidence of loss of independence than the number of present teeth. This novel finding suggests that prosthodontic rehabilitation for tooth loss possibly prevents the future incidence of this life-event. Geriatr Gerontol Int 2022; ••: ••-••.

  41. Number of functional teeth more strongly predicts all-cause mortality than number of present teeth in Japanese older adults. Peer-reviewed

    Kenji Maekawa, Tomoko Ikeuchi, Shoji Shinkai, Hirohiko Hirano, Masahiro Ryu, Katsushi Tamaki, Hirofumi Yatani, Takuo Kuboki, Aya Kimura-Ono, Takeshi Kikutani, Takashi Suganuma, Yasunori Ayukawa, Tomoya Gonda, Toru Ogawa, Masanori Fujisawa, Shoichi Ishigaki, Yutaka Watanabe, Akihiko Kitamura, Yu Taniguchi, Yoshinori Fujiwara, Ayako Edahiro, Yuki Ohara, Junichi Furuya, Junko Nakajima, Kento Umeki, Kentaro Igarashi, Yasuhiro Horibe, Yoshihiro Kugimiya, Yasuhiko Kawai, Hideo Matsumura, Tetsuo Ichikawa, Shuji Ohkawa

    Geriatrics & gerontology international　20　(6)　607-614　2020/06

    DOI： 10.1111/ggi.13911 　

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    AIM: Previous studies on the association between intraoral conditions and mortality in community-dwelling older individuals reported that fewer present teeth (PT) are significant risk factors for mortality. However, how the number of PT relative to the number of functional teeth (FT), including both present and rehabilitated teeth, influences mortality has not been investigated fully. This study examined the impact of the number of FT on mortality among community-dwelling Japanese older adults. METHODS: This study was a retrospective, observational and population-based follow-up study, which examined 1188 older individuals who participated in an annual geriatric health examination from 2009 to 2015. The average follow-up period was 1697.0 ± 774.5 days. The primary outcome was all-cause mortality at follow-up. The numbers of PT and FT of each participant were counted during an oral examination. In addition, demographics, clinical variables, blood nutrient markers, physical functions and perceived masticatory function were measured. RESULTS: Kaplan-Meier analysis, followed by a log-rank test, revealed that fewer PT (P < 0.001) and FT (P = 0.002) were significantly associated with a reduced survival rate. Cox's proportional hazard analysis indicated that the number of FT, but not the number of PT, was a significant independent mortality risk factor after adjusting for demographics, clinical variables, nutrient markers and physical functioning (P = 0.036, hazard ratio: 2.089). CONCLUSIONS: Current results suggest that the number of FT more strongly predicts all-cause mortality than the number of PT among community-dwelling older adults. Further studies are necessary to consider the confounding of socioeconomic status and disability status. Geriatr Gerontol Int 2020; ••: ••-••.

  42. Bactericidal activity and recovery effect of hydroxyl radicals generated by ultraviolet irradiation and silver ion application on an infected titanium surface. International-journal Peer-reviewed

    Taichi Tenkumo, Kirika Ishiyama, Oleg Prymak, Keisuke Nakamura, Midori Shirato, Toru Ogawa, Makiko Miyashita, Masatoshi Takahashi, Matthias Epple, Taro Kanno, Keiichi Sasaki

    Scientific reports　10　(1)　8553-8553　2020/05/22

    DOI： 10.1038/s41598-020-65411-4 　

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    This study investigated the bactericidal effect, the underlying mechanisms of treatment, and recovery of biocompatibility of the infected titanium surface using a combination treatment of silver ion application and ultraviolet-A (UV-A) light irradiation. Streptococcus mutans and Aggregatibacter actinomycetemcomitans were used in suspension and as a biofilm on a titanium surface to test for the bactericidal effect. The bactericidal effect of the combination treatment was significantly higher than that of silver ion application or UV-A light irradiation alone. The bactericidal effect of the combination treatment was attributable to hydroxyl radicals, which generated from the bacterial cell wall and whose yield increased with the silver concentration. To assess the biocompatibility, proliferation and calcification of MC3T3E1 cells were evaluated on the treated titanium surface. The treated titanium screws were implanted into rat tibias and the removal torques were measured 28 days post-surgery. The titanium surface that underwent the combination treatment exhibited recovery of biocompatibility by allowing cellular proliferation or calcification at levels observed in the non-infected titanium surfaces. The removal torque 28 days after surgery was also comparable to the control values. This approach is a novel treatment option for peri-implantitis.

  43. Reduction of inflammation in a chronic periodontitis model in rats by TNF-α gene silencing with a topically applied siRNA-loaded calcium phosphate paste. International-journal Peer-reviewed

    Taichi Tenkumo, Leonardo Rojas-Sánchez, Juan Ramón Vanegas Sáenz, Toru Ogawa, Makiko Miyashita, Nobuhiro Yoda, Oleg Prymak, Viktoriya Sokolova, Keiichi Sasaki, Matthias Epple

    Acta biomaterialia　105　263-279　2020/03/15

    DOI： 10.1016/j.actbio.2020.01.031 　

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    We developed a calcium phosphate-based paste containing siRNA against TNF-α and investigated its anti-inflammatory and bone-healing effects in vitro and in vivo in a rat periodontitis model. The bioactive spherical CaP/PEI/siRNA/SiO2 nanoparticles had a core diameter of 40-90 nm and a positive charge (+23 mV) that facilitated cellular uptake. The TNF- α gene silencing efficiency of the nanoparticles in J774.2 monocytes, gingival-derived cells, and bone marrow-derived cells was 12 ± 2%, 36 ± 8%, and 35 ± 22%, respectively. CaP/PEI/siRNA/SiO2 nanoparticles cancelled the suppression of alkaline phosphatase (ALP) activity in LPS-stimulated bone marrow-derived cells. In vivo, ALP mRNA was up-regulated, TNF-α mRNA was down-regulated, and the amount of released TNF-α was significantly reduced after topical application of the calcium phosphate-based paste containing siRNA-loaded nanoparticles. The number of TNF-α-positive cells in response to CaP/PEI/siRNA/SiO2 nanoparticle application was lower than that observed in the absence of siRNA. Elevated ALP activity and numerous TRAP-positive cells (osteoclasts) were observed in response to the application of all calcium phosphate pastes. These results demonstrate that local application of a paste consisting of siRNA-loaded calcium phosphate nanoparticles successfully induces TNF-α silencing in vitro and in vivo and removes the suppression of ALP activity stimulated by inflammation. STATEMENT OF SIGNIFICANCE: We developed a calcium phosphate-based paste containing nanoparticles loaded with siRNA against TNF-α. The nanoparticles had a core diameter of 40-90 nm and positive charge (+23 mV). The anti-inflammatory and osteoinductive effects of the paste were investigated in vitro and in vivo in a rat periodontitis model. In vitro, the TNF-α gene silencing efficiency of the nanoparticles in J774.2 monocytes, gingival-derived cells, and bone marrow-derived cells was 12 ± 2%, 36 ± 8%, and 35 ± 22%, respectively. The ALP activity of bone marrow-derived cells was recovered. In vivo, TNF-α mRNA was down-regulated and the amount of released TNF-α was significantly reduced, whereas the ALP mRNA was up-regulated. Elevated ALP activity and TRAP-positive cells were observed by immunohistochemistry.

  44. Visible light-induced photocatalytic and antibacterial activity of N-doped TiO2. International-journal Peer-reviewed

    Misato Iwatsu, Hiroyasu Kanetaka, Takayuki Mokudai, Toru Ogawa, Masakazu Kawashita, Keiichi Sasaki

    Journal of biomedical materials research. Part B, Applied biomaterials　108　(2)　451-459　2020/02

    DOI： 10.1002/jbm.b.34401 　

    ISSN： 1552-4973

  45. Use of cellulose nanofibers as a denture immersing solution. Peer-reviewed

    Wei Zou, Guang Hong, Yukiko Yamazaki, Kazuma Takase, Toru Ogawa, Jumpei Washio, Nobuhiro Takahashi, Keiichi Sasaki

    Dental materials journal　39　(1)　80-88　2020/01/31

    DOI： 10.4012/dmj.2018-388 　

    ISSN： 0287-4547

    eISSN： 1881-1361

  46. Histomorphometric assessments of peri-implant bone around Ti-Nb-Sn alloy implants with low Young's modulus. Peer-reviewed

    Naru Shiraishi, Hiroshi Masumoto, Kenta Takahashi, Taichi Tenkumo, Takahisa Anada, Osamu Suzuki, Toru Ogawa, Keiichi Sasaki

    Dental materials journal　39　(1)　148-153　2020/01/31

    DOI： 10.4012/dmj.2018-376 　

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    Many β-Ti alloys have been developed for, and used in, medical devices because of the corrosion resistance, biocompatibility, and exceptionally low Young's modulus. The aim of the present study was to investigate the histomorphometric aspects of peri-implant bone around Ti-Nb-Sn alloy implants and compare them with those in the case of commercially pure Ti (Ti). Fluorescent morphological observations of ST-2 cells on the substrate were performed and bone morphogenesis around implants in rat femur was evaluated. There was no difference between the cell morphology on Ti and those on the Ti-Nb-Sn alloy during observation for 24 h. A comparison of the Ti-Nb-Sn alloy implant and the Ti implant showed no significant differences between the bone-to-implant contact ratios or the bone fractions. These results suggest that the biological adaptations with Ti-Nb-Sn implants during a healing period are similar to those with Ti. Ti-Nb-Sn is therefore suitable for use in dental implants.

  47. Tightening and Loosening of the Abutment Screw Negatively Affects Implant Osseointegration in the Early Healing Stage in Rat Tibiae. International-journal Peer-reviewed

    Kenta Shobara, Toru Ogawa, Ratri M Sitalaksmi, Akiyo Ito, Makiko Miyashita, Aya Shibamoto, Keiichi Sasaki

    The International journal of prosthodontics　2020/01/28

    DOI： 10.11607/ijp.6398 　

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    PURPOSE: To examine the effect of tightening and loosening the dental implant screw on implant osseointegration in an elderly rat model. MATERIALS AND METHODS: Titanium dental implants were inserted in the bilateral tibiae of 34 elderly Wistar rats (1 year and 3 months old). Rats were randomly divided into five groups: control (no loading); immediate loading (IL) (vertical load [3 Hz for 15 minutes/day] immediately after implantation); early loading (EL) (load started on postoperative day 7); five times abutment removal (R5) (tightening and loosening of the abutment screw once per day for 5 days each week); and two times abutment screw removal (R2) (tightening and loosening of the abutment screw once per day for 2 days each week). After 4 weeks, the rats were euthanized, and the bone structure surrounding the dental implants was evaluated using microcomputed tomography analysis. RESULTS: Osseointegration failed more frequently in the EL, R2, and R5 groups than in the control and IL groups (P = .06). The EL, R2, and R5 groups also tended to have lower relative gray values than the control and IL groups. CONCLUSION: Tightening and loosening the abutment screw might negatively affect dental implant osseointegration in the early healing stage in older adults.

  48. Erratum to: Use of cellulose nanofibers as a denture immersing solution. Peer-reviewed

    Wei Zou, Guang Hong, Yukiko Yamazaki, Kazuma Takase, Toru Ogawa, Jumpei Washio, Nobuhiro Takahashi, Keiichi Sasaki

    Dental materials journal　39　(2)　327-327　2020

    DOI： 10.4012/dmj.2018-388-e 　

  49. Effect of mandibular position achieved using an oral appliance on genioglossus activity in healthy adults during sleep. International-journal Peer-reviewed

    Michikazu Matsuda, Toru Ogawa, Ratri M Sitalaksmi, Makiko Miyashita, Toshimi Ito, Keiichi Sasaki

    Head & face medicine　15　(1)　26-26　2019/11/04

    DOI： 10.1186/s13005-019-0210-z 　

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    BACKGROUND: Oral appliances (OAs) are generally designed to displace the mandible anteriorly and downward, to increase the airway patency. The present study aimed to examine the relationship between genioglossus (GG) muscle activity and mandibular position, considering both anterior and vertical displacements during sleep. METHODS: Seven healthy male adults aged 29.4 ± 1.99 years were evaluated. Maxillary and mandibular OAs were fabricated from 2-mm-thick resin plates with pressure-welding. The activity of the left GG was recorded using two silver ball electrodes attached to the lingual edge of the mandibular OA. Respiratory status and right masseter muscle activity were measured by an airflow sensor and surface electrodes, respectively. Electroencephalography was used to determine the sleep status. Stage 2 (the second stage of sleep) was defined as the state of sleeping. Four test conditions with different mandibular positions (0 and 50% anterior protrusion) and bite openings (4 mm and 12 mm) were examined. RESULTS: GG activity in SL4A (4 mm bite opening, 50% protrusion during sleep) and SL12 (12 mm bite opening, 0% protrusion during sleep) were significantly higher than that in SL4 (4 mm bite opening, 0% protrusion during sleep). Respiratory volume did not significantly differ between all test conditions. CONCLUSION: GG activity is influenced not only by anterior protrusion of the mandible but also by vertical displacement during sleep. Thus, when determining the effectiveness of intraoral appliances in the treatment of obstructive sleep apnea, both protrusion and the size of the mandibular opening should be evaluated and taken into account.

  50. Effect of Functionally-Graded Calcium Titanate Film, Prepared by Metal-Organic Chemical Vapor Deposition, on Titanium Implant Peer-reviewed

    Naru Shiraishi, Risa Ishiko-Uzuka, Kenta Takahashi, Toru Ogawa, Takahisa Anada, Osamu Suzuki, Takashi Goto, Keiichi Sasaki

    Applied Sciences　9　(1)　172-182　2019/01

    DOI： 10.3390/app9010172 　

    eISSN： 2076-3417

  51. Reorganization of motor unit activity at different sites within the human masseter muscle during experimental masseter pain. International-journal Peer-reviewed

    Bushra Malik, Terry Whittle, Toru Ogawa, Greg M Murray

    European journal of oral sciences　126　(5)　400-410　2018/10

    DOI： 10.1111/eos.12561 　

    ISSN： 0909-8836

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    The aims were to test the hypotheses that experimental masseter muscle pain leads to recruitment and/or derecruitment of motor units at different sites within the masseter and that the patterns of change in motor unit activity differ between sites. Single motor unit (SMU) activity was recorded at two sites within the right masseter [superior/anterior, inferior/posterior (IP)] during isometric biting tasks (ramp, step level) on an intraoral force transducer in 17 participants during three experimental blocks comprising no infusion (baseline), 5% hypertonic saline infusion (pain), or isotonic saline infusion (control). A visual analog scale (VAS) was used to score pain intensity. The VAS scores were statistically significantly greater during infusion of hypertonic saline than during infusion of isotonic saline. No significant differences in force levels and rates of force change were found between experimental blocks. In comparison with isotonic saline infusion, SMUs could be recruited and derecruited at both sites during hypertonic saline infusion. The frequency of recruitment or derecruitment, in comparison with no change, was statistically significantly greater at the IP site than at the superior/anterior site. Experimental noxious masseter stimulation results in a reorganization of motor unit activity throughout the muscle, and the pattern of reorganization may be different in different regions of the muscle.

  52. The effect of low-magnitude high-frequency loading on peri-implant bone healing and implant osseointegration in Beagle dogs. Peer-reviewed

    Shuhua Wang, Toru Ogawa, Sheng Zheng, Makiko Miyashita, Taichi Tenkumo, Zhiyuan Gu, Wenhai Lian, Keiichi Sasaki

    Journal of prosthodontic research　62　(4)　497-502　2018/10

    DOI： 10.1016/j.jpor.2018.07.004 　

    ISSN： 1883-1958

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    PURPOSE: Low-magnitude, high-frequency (LMHF) loading plays an important role in bone healing. The present study aimed to evaluate the effect of LMHF loading applied directly to titanium dental implants on peri-implant bone healing and implant osseointegration. METHODS: The mandibular premolars and molars were extracted from six male Beagle dogs. Three months post-extraction, each of the six dogs had three titanium implants (Aadva Standard Implant Narrow, Φ3.3×8mm) inserted into the mandibular premolar and molar area (three implants per side). In each animal, one side was randomly selected to undergo daily LMHF loading (treatment group), while the other side had no further intervention (control). The loading was applied directly to the implant abutment using an individual jig and a custom-made loading device (8μm, 100Hz). The implant stability quotient (ISQ) was tested every week. Three dogs were euthanized after 2 weeks, and three were euthanized after 8 weeks. Tissue samples were fixed and stained for micro-computed tomography (micro-CT) and histomorphometric analyses. Data were analyzed statistically, with significance set at p<0.05. RESULTS: The treatment group had significantly increased peri-implant bone volume relative to tissue volume in region of interest 2 (100-500μm) compared with the control group after 2 weeks of loading (p<0.05); however, there was no significant difference between groups after 8 weeks. The ISQ value and the micro-CT results did not differ between groups during the study period. CONCLUSIONS: LMHF loading positively influenced peri-implant bone healing in the early healing period.

  53. Na18F accumulates on the compressive side of peri-implant bone under immediate loading. Peer-reviewed

    Miou Yamamoto, Toru Ogawa, Masayoshi Yokoyama, Yoshihito Funaki, Kenta Shobara, Aya Shibamoto, Juan Ramón Vanegas Sáenz, Keiichi Sasaki

    Odontology　106　(3)　232-237　2018/07

    Publisher: Springer Tokyo

    DOI： 10.1007/s10266-017-0327-0 　

    ISSN： 1618-1255 1618-1247

  54. 生体内荷重測定に基づくインプラント生体力学研究の発展と課題 Invited

    依田 信裕, 小山 重人, 小川 徹, 松舘 芳樹, 重光 竜二, 川田 哲男, 佐々木 啓一

    日本口腔インプラント学会誌　31　(2)　135-143　2018/06

    Publisher: (公社)日本口腔インプラント学会

    ISSN： 0914-6695

    eISSN： 2187-9117

  55. Evaluation of implant screw loosening by resonance frequency analysis with triaxial piezoelectric pick-up: in vitro model and in vivo animal study. International-journal Peer-reviewed

    Makiko Miyashita, Toru Ogawa, Hideki Naito, Aya Shibamoto, Angelina Shuhua Wang, Kenta Shobara, Keiichi Sasaki

    Clinical oral investigations　22　(5)　2129-2134　2018/06

    Publisher: Springer Verlag

    DOI： 10.1007/s00784-018-2467-1 　

    ISSN： 1436-3771 1432-6981

  56. Effects of polyphenols on doxorubicin-induced oral keratinocyte cytotoxicity and anticancer potency against oral cancer cells. International-journal Peer-reviewed

    Hong Sheng, Toru Ogawa, Yoshimi Niwano, Keiichi Sasaki, Katsuro Tachibana

    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology　47　(4)　368-374　2018/04

    DOI： 10.1111/jop.12685 　

    ISSN： 0904-2512

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    BACKGROUND: Normal human oral keratinocytes are highly sensitive to anticancer drugs including doxorubicin. Resveratrol, epigallocatechin gallate, and tannic acid are polyphenolic compounds that were reported to have cardioprotective effect when combined with doxorubicin. However, it is unknown whether these polyphenols could protect normal human oral keratinocytes against doxorubicin-induced cytotoxicity without weakening its cytotoxic potential against oral cancer cells. Here, we examined the effects of the 3 polyphenolic compounds on doxorubicin-induced cytotoxicity in normal human oral keratinocytes and also investigated their effects on doxorubicin potency in HSC-2 human oral squamous cell carcinoma cells. METHODS: Cell viability was evaluated, followed by the analysis of apoptosis and necrosis. The changes in intracellular reactive oxygen species at the early stage after treatment were also examined. RESULTS: The results revealed that resveratrol in combination with doxorubicin additively augmented doxorubicin cytotoxicity in both types of cells. However, epigallocatechin gallate and tannic acid at a certain concentration mitigated the doxorubicin-induced keratinocyte toxicity mainly due to reduced doxorubicin-induced necrosis in normal human oral keratinocytes without weaken doxorubicin anticancer efficacy. The exact mechanism is still unknown but intracellular reactive oxygen species might be not the sole factor. CONCLUSIONS: This study for the first time reported the effects of resveratrol, epigallocatechin gallate, and tannic acid on doxorubicin-induced cytotoxicity in normal oral keratinocytes and oral cancer cells. The combined use of epigallocatechin gallate or tannic acid with doxorubicin at a certain concentration could mitigate doxorubicin-induced keratinocyte cytotoxicity without weakening doxorubicin anticancer efficacy.

  57. Effect of high-frequency loading and parathyroid hormone administration on peri-implant bone healing and osseointegration. International-journal Peer-reviewed

    Aya Shibamoto, Toru Ogawa, Joke Duyck, Katleen Vandamme, Ignace Naert, Keiichi Sasaki

    International journal of oral science　10　(1)　6-6　2018/03/13

    DOI： 10.1038/s41368-018-0009-y 　

    ISSN： 1674-2818

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    The objective of this study is to examine the effect of low-magnitude, high-frequency (LMHF) loading, and anti-osteoporosis medications such as parathyroid hormone (PTH) and bisphosphonates on peri-implant bone healing in an osteoporosis model, and to assess their combined effects on these processes. Thirteen-week-old ovariectomized rats (n = 44) were divided into three groups: PTH, alendronate, and saline. After 3 weeks of drug administration, titanium implants were inserted into the tibiae. Each group was subdivided into two groups: with or without LMHF loading via whole-body vibration (50 Hz at 0.5 g, 15 min per day, 5 days per week). Rats were killed 4 weeks following implantation. Removal torque test, micro-CT analyses (relative gray (RG) value, water = 0, and implant = 100), and histomorphometric analyses (bone-to-implant contact (BIC) and peri-implant bone formation (bone volume/tissue volume (BV/TV))) were performed. Removal torque values and BIC were significantly differed by loading and drug administration (ANOVA). Post hoc analysis showed that PTH-treated groups were significantly higher than the other drug-treated groups. BV/TV was significantly enhanced by PTH administration. In cortical bone, RG values were significantly increased by loading. In trabecular bone, however, RG values were significantly increased by PTH administration. These findings suggest that LMHF loading and PTH can act locally and additively on the bone healing process, improving the condition of implant osseointegration.

  58. Effect of bite openings and mandibular protrusion on genioglossus muscle activity in healthy adults with oral appliance. Peer-reviewed

    Jianlan Long, Toru Ogawa, Toshimi Ito, Michikazu Matsuda, Wei Li, Haiyang Yu, Keiichi Sasaki

    Odontology　106　(1)　90-95　2018/01

    Publisher: Springer Tokyo

    DOI： 10.1007/s10266-017-0299-0 　

    ISSN： 1618-1255 1618-1247

  59. Periodontal tactile sensation and occlusal loading condition of autotransplanted teeth: A retrospective pilot study. Peer-reviewed

    Tasuku Suzuki, Toru Ogawa, Jianlan Long, Juan Ramón Vanegas Sáenz, Makiko Miyashita, Michikazu Matsuda, Keiichi Sasaki

    Journal of prosthodontic research　62　(1)　84-88　2018/01

    Publisher: Elsevier Ltd

    DOI： 10.1016/j.jpor.2017.06.005 　

    ISSN： 1883-1958

  60. Evaluation of peri-implant bone metabolism under immediate loading using high-resolution Na18F-PET. International-journal Peer-reviewed

    Yutaka Matsuo, Toru Ogawa, Miou Yamamoto, Aya Shibamoto, Juan Ramón Vanegas Sáenz, Masayoshi Yokoyama, Yoshiaki Kanda, Jun Toyohara, Keiichi Sasaki

    Clinical oral investigations　21　(6)　2029-2037　2017/07

    DOI： 10.1007/s00784-016-1992-z 　

    ISSN： 1432-6981

    eISSN： 1436-3771

  61. Load distribution on abutment tooth, implant and residual ridge with distal-extension implant-supported removable partial denture. Peer-reviewed

    Yoshiki Matsudate, Nobuhiro Yoda, Masahide Nanba, Toru Ogawa, Keiichi Sasaki

    Journal of prosthodontic research　60　(4)　282-288　2016/10

    DOI： 10.1016/j.jpor.2016.01.008 　

    ISSN： 1883-1958

    eISSN： 2212-4632

  62. Effects of Food Texture on Three-Dimensional Loads on Implants During Mastication Based on In Vivo Measurements. International-journal Peer-reviewed

    Nobuhiro Yoda, Toru Ogawa, Yoshinori Gunji, Juan R Vanegas, Tetsuo Kawata, Keiichi Sasaki

    Implant dentistry　25　(4)　515-9　2016/08

    DOI： 10.1097/ID.0000000000000443 　

    ISSN： 1056-6163

  63. Effect of mandibular advancement splint treatment on tongue shape in obstructive sleep apnea. International-journal Peer-reviewed

    Toru Ogawa, Jianlan Long, Kate Sutherland, Andrew S L Chan, Keiichi Sasaki, Peter A Cistulli

    Sleep & breathing = Schlaf & Atmung　19　(3)　857-63　2015/09

    DOI： 10.1007/s11325-014-1101-y 　

    ISSN： 1520-9512

    eISSN： 1522-1709

  64. Effect of insertion torque on titanium implant osseointegration: an animal experimental study. International-journal Peer-reviewed

    Joke Duyck, Rutger Roesems, Marcio V Cardoso, Toru Ogawa, Germana De Villa Camargos, Katleen Vandamme

    Clinical oral implants research　26　(2)　191-6　2015/02

    DOI： 10.1111/clr.12316 　

    ISSN： 0905-7161

    eISSN： 1600-0501

  65. Stimulation of titanium implant osseointegration through high-frequency vibration loading is enhanced when applied at high acceleration. International-journal Peer-reviewed

    Toru Ogawa, Katleen Vandamme, Xiaolei Zhang, Ignace Naert, Tine Possemiers, Amol Chaudhari, Keiichi Sasaki, Joke Duyck

    Calcified tissue international　95　(5)　467-75　2014/11

    DOI： 10.1007/s00223-014-9896-x 　

    ISSN： 0171-967X

    eISSN： 1432-0827

  66. Biological-data-based finite-element stress analysis of mandibular bone with implant-supported overdenture. International-journal Peer-reviewed

    Ryuji Shigemitsu, Nobuhiro Yoda, Toru Ogawa, Tetsuo Kawata, Yoshinori Gunji, Yuki Yamakawa, Kiyohiro Ikeda, Keiichi Sasaki

    Computers in biology and medicine　54　44-52　2014/11

    DOI： 10.1016/j.compbiomed.2014.08.018 　

    ISSN： 0010-4825

    eISSN： 1879-0534

  67. Influence of immediate and early loading on bone metabolic activity around dental implants in rat tibiae. International-journal Peer-reviewed

    Miou Yamamoto, Toru Ogawa, Masayoshi Yokoyama, Shigeto Koyama, Keiichi Sasaki

    Clinical oral implants research　25　(9)　1084-90　2014/09

    DOI： 10.1111/clr.12218 　

    ISSN： 0905-7161

    eISSN： 1600-0501

  68. 東北大学病院における全身麻酔下歯科治療チームの設立

    水田 健太郎, 安田 真, 笹崎 弘己, 小川 徹, 冨士 岳志, 橋元 亘, 高橋 温, 山田 亜矢, 正木 英二, 五十嵐 薫

    みちのく歯学会雑誌　44　(1-2)　36-37　2013/12

    Publisher: 東北地区歯科医学会

    ISSN： 0385-0099

  69. Stress distribution in the peri-implant bone with splinted and non-splinted implants by in vivo loading data-based finite element analysis. Peer-reviewed

    Ryuji Shigemitsu, Toru Ogawa, Tetsuya Matsumoto, Nobuhiro Yoda, Yoshinori Gunji, Yuki Yamakawa, Kiyohiro Ikeda, Keiichi Sasaki

    Odontology　101　(2)　222-6　2013/07

    DOI： 10.1007/s10266-012-0077-y 　

    ISSN： 1618-1247 1618-1255

  70. In Vivo Load Measurement for Evaluating the Splinting Effects of Implant-Supported Superstructures: A Pilot Study Peer-reviewed

    Nobuhiro Yoda, Yoshinori Gunji, Toru Ogawa, Tetsuo Kawata, Keiichi Sasaki

    INTERNATIONAL JOURNAL OF PROSTHODONTICS　26　(2)　143-146　2013/03

    DOI： 10.11607/ijp.3223 　

    ISSN： 0893-2174

  71. In vivo assessment of the effect of controlled high- and low-frequency mechanical loading on peri-implant bone healing. International-journal Peer-reviewed

    Xiaolei Zhang, Katleen Vandamme, Antonia Torcasio, Toru Ogawa, G Harry van Lenthe, Ignace Naert, Joke Duyck

    Journal of the Royal Society, Interface　9　(72)　1697-704　2012/07/07

    DOI： 10.1098/rsif.2011.0820 　

    ISSN： 1742-5689

  72. Positive effect of whole-Body vibration loading on peri-Implant bone healing and implant osseointegration Peer-reviewed

    Toru Ogawa, Xiaolei Zhang, Ignace Naert, Keiichi Sasaki, Joke Duyck

    Interface Oral Health Science 2011　349-351　2012/01/01

    Publisher: Springer Japan

    DOI： 10.1007/978-4-431-54070-0_101 　

  73. Enhancement of implant osseointegration by high-frequency low-magnitude loading. International-journal Peer-reviewed

    Xiaolei Zhang, Antonia Torcasio, Katleen Vandamme, Toru Ogawa, G Harry van Lenthe, Ignace Naert, Joke Duyck

    PloS one　7　(7)　e40488　2012

    DOI： 10.1371/journal.pone.0040488 　

    ISSN： 1932-6203

  74. 下顎臼歯の歯根膜触・圧覚と咬合力負担に関わる因子との関連． Peer-reviewed

    小川 徹, 大石 直, 鈴木 祐, 伊藤利実, 川田哲男, 佐々木啓一

    顎機能誌　18　(2)　139-151　2012

    Publisher:

    DOI： 10.7144/sgf.18.139 　

    ISSN： 1340-9085

    eISSN： 1883-986X

  75. Tactile sensation and occlusal loading condition of mandibular premolars and molars. Peer-reviewed

    Toru Ogawa, Tasuku Suzuki, Nao Oishi, Xiaolei Zhang, Ignace Naert, Keiichi Sasaki

    Odontology　99　(2)　193-6　2011/07

    DOI： 10.1007/s10266-011-0007-4 　

    ISSN： 1618-1247

  76. The effect of whole-body vibration on peri-implant bone healing in rats. International-journal Peer-reviewed

    Toru Ogawa, Xiaolei Zhang, Ignace Naert, Peter Vermaelen, Christophe M Deroose, Keiichi Sasaki, Joke Duyck

    Clinical oral implants research　22　(3)　302-7　2011/03

    DOI： 10.1111/j.1600-0501.2010.02020.x 　

    ISSN： 0905-7161

  77. Oral appliance treatment for obstructive sleep apnoea patients with severe dental condition Peer-reviewed

    T. Ogawa, T. Ito, M. V. Cardoso, T. Kawata, K. Sasaki

    JOURNAL OF ORAL REHABILITATION　38　(3)　202-207　2011/03

    DOI： 10.1111/j.1365-2842.2010.02138.x 　

    ISSN： 0305-182X

    eISSN： 1365-2842

  78. Influence of whole-body vibration time on peri-implant bone healing: a histomorphometrical animal study. International-journal Peer-reviewed

    Toru Ogawa, Tine Possemiers, Xiaolei Zhang, Ignace Naert, Amol Chaudhari, Keiichi Sasaki, Joke Duyck

    Journal of clinical periodontology　38　(2)　180-5　2011/02

    DOI： 10.1111/j.1600-051X.2010.01637.x 　

    ISSN： 0303-6979

  79. Effect of Tilted and Short Distal Implants on Axial Forces and Bending Moments in Implants Supporting Fixed Dental Prostheses: An In Vitro Study Peer-reviewed

    Toru Ogawa, Sandra Dhaliwal, Ignace Naert, Atsushi Mine, Mats Kronstrom, Keiichi Sasaki, Joke Duyck

    INTERNATIONAL JOURNAL OF PROSTHODONTICS　23　(6)　566-573　2010/11

    ISSN： 0893-2174

    eISSN： 1942-4426

  80. Histological, histomorphometrical, and radiological evaluation of an experimental implant design with a high insertion torque. International-journal Peer-reviewed

    Joke Duyck, Livía Corpas, Stephanie Vermeiren, Toru Ogawa, Marc Quirynen, Katleen Vandamme, Reinhilde Jacobs, Ignace Naert

    Clinical oral implants research　21　(8)　877-84　2010/08

    DOI： 10.1111/j.1600-0501.2010.01895.x 　

    ISSN： 0905-7161

    eISSN： 1600-0501

  81. Impact of implant number, distribution and prosthesis material on loading on implants supporting fixed prostheses Peer-reviewed

    T. Ogawa, S. Dhaliwal, I. Naert, A. Mine, M. Kronstrom, K. Sasaki, J. Duyck

    JOURNAL OF ORAL REHABILITATION　37　(7)　525-531　2010/07

    DOI： 10.1111/j.1365-2842.2010.02076.x 　

    ISSN： 0305-182X

  82. The study of mandibular position applied to oral appliance for treatment of obstructive sleep apnea syndrome Peer-reviewed

    Toshimi Ito, Toru Ogawa, Tasuku Suzuki, Michikazu Matsuda, Keiichi Sasaki

    INTERFACE ORAL HEALTH SCIENCE 2009　349-350　2010

    DOI： 10.1007/978-4-431-99644-6_103 　

  83. Treatment using oral appliance for obstructive sleep apnea syndrome patients with multiple missing teeth. International-journal Peer-reviewed

    Toru Ogawa, Toshimi Ito, Marcio V Cardoso, Tetsuo Kawata, Keiichi Sasaki

    Sleep medicine　10　(7)　809-11　2009/08

    DOI： 10.1016/j.sleep.2008.10.003 　

    ISSN： 1389-9457

  84. Development of in vivo measuring system of the pressure distribution under the denture base of removable partial denture. Peer-reviewed

    Kei Kubo, Tetsuo Kawata, Hanako Suenaga, Nobuhiro Yoda, Ryuji Shigemitsu, Toru Ogawa, Keiichi Sasaki

    Journal of prosthodontic research　53　(1)　15-21　2009/01

    DOI： 10.1016/j.jpor.2008.08.006 　

    ISSN： 1883-1958

    eISSN： 2212-4632

  85. 閉塞型睡眠時無呼吸症症例へのオーラルアプライアンス治療―補綴学的見地からの検討. Peer-reviewed

    小川 徹

    日補綴誌　52　(2)　244-247　2008/04

    Publisher:

    DOI： 10.2186/jjps.52.244 　

    ISSN： 0389-5386

    eISSN： 1883-177X

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    PATIENT: The patient was a 61-year-old woman with obstructive sleep apnea syndrome (OSAS) who was referred to our hospital for oral applianceOAtreatment. A mandibular advancing OA designed considering stomatognathic functions was fabricated. The OA was a one-piece maxillary splint and provided flat occlusal-plane guiding of the mandible into a therapeutic protrusive position at the mouth closing. OSAS indexes obtained by polysomnography after the OA treatment decreased than the values before treatment. No side effect was observed over the ensuing 3.5 years. DISCUSSION: It has been reported the OAs for OSAS incur a number of side effects such as disorders of stomatognathic function, teeth displacement, and change of occlusion. In this case, no such sign or symptom was observed. Proper design of OA might contribute to a favorable prognosis in OSAS patients. CONCLUSION: This report suggests that OA designed considering stomatognathic functions is effective against OSAS and prevents side effects.

  86. [Multivariate analysis of factors affecting the status of wearing removable partial dentures]. Peer-reviewed

    Shintarou Gorai, Shigeto Koyama, Takahiro Chiba, Toru Ogawa, Kouki Hatori, Keiichi Sasaki

    Nihon Hotetsu Shika Gakkai zasshi　52　(2)　126-34　2008/04

    Publisher:

    DOI： 10.2186/jjps.52.126 　

    ISSN： 0389-5386

    eISSN： 1883-177X

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    PURPOSE: The purpose of this retrospective cohort study was to investigate factors that affected the status of wearing removable partial dentures (RPDs) using a multivariate analysis. METHODS: One hundred and sixty-one patients were treated with definitive dentures that were delivered by dental students under teacher supervision at Tohoku University Hospital between 1996 and 2001. Of the 161 patients, 67 patients who agreed to undergo a follow-up examination participated in this study. The subjects were 18 men and 49 women with a mean age of 66.0+/-9.5 years. They were re-examined 5 years after treatment. The status of wearing the RPDs was categorized into three groups, i.e: successful, wearing their original RPDs constantly for 5 years; replaced, wearing re-fabricated RPDs within 5 years, and failed; interrupted wearing the RPDs within 5 years. Factors that affected the status were also examined. The analyzed variables in this study were sex and age of subjects, previous experience in wearing RPDs, location of RPDs and edentulous area, number of occluding pairs, number of missing teeth, placement of RPDs on opposite jaw, denture base type, number of abutment teeth, type of clasp, and number of rests. A stepwise multiple logistic regression analysis was used to determine factors affecting the status of wearing RPDs. RESULTS: The response rate was 41.6%. Of the 90 RPDs, 55 RPDs were regarded as successful, 21 as replaced, and 14 as failed. Statistically significant correlations were found between denture usage and the age of subjects, the location of edentulous area, number of occluding pairs, and number of rests (p<0.05). CONCLUSION: The results suggest the importance of considering the significant factors mentioned above for treatment planning and designing of RPDs.

  87. 歯科医療と顎口腔系のバイオメカニクス.

    佐々木啓一, 依田信裕, 重光竜二, 末永華子, 鈴木祐子, 久保圭, 川田哲男, 小川徹

    バイオエンジニアリング講演論文集　21　321-322　2008

    ISSN： 1348-2920

  88. The analysis of the load exerted on the implants supporting an overdenture based on in vivo measurement. Peer-reviewed

    Yoda N, Ogawa T, Gunji Y, Kawata T, Kuriyagawa T, Sasaki K

    Prosthodont Res Pract　7　(2)　258-260　2008

    Publisher: Japan Prosthodontic Society

    DOI： 10.2186/prp.7.258 　

    ISSN： 1347-7021

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    The aims of this study were to measure the three-dimensional (3-D) loads exerted on the implants supporting an overdenture during function in vivo and to clarify the effect of the number of the implants on the loads. The load-measuring devices were mounted on the implants inserted in the mandible of a 62 aged female subject. Either two or four implants connected with a bar were used for supporting her overdenture. The loads on the implants were expressed three dimensionally as load vectors and were analyzed in the coordinates based on the Frankfort horizontal plane and sagittal plane. The tasks examined were maximum voluntary clenching (MVC) and gum chewing (GC). The total load exerted on the implants with a four-implant supported overdenture (4I-Od) was larger than that with a two-implants supported overdenture (2I-Od) at MVC. The maximum occlusal force on the overdenture showed the same manner (p<0.01). The directions of the loads were posterior and lateral at MVC. The total load exerted on the implants located on the working side, was larger than that on the implants located on the non-working side during GC in the case of 4I-Od. The similar manner was also observed in the 2I-Od. The tensile loads were registered during GC. The functional loads exerted on the individual implants in the case of 4I-Od were smaller than those in the 2I-Od. The loads on the implants during function are thus affected by the number of implants supporting the overdenture.

  89. Effects of a removable partial denture and its rest location on the forces exerted on an abutment tooth in vivo Peer-reviewed

    Tetsuo Kawata, Takeshi Kawaguchi, Nobuhiro Yoda, Toru Ogawa, Tsunemoto Kuriyagawa, Keiichi Sasaki

    INTERNATIONAL JOURNAL OF PROSTHODONTICS　21　(1)　50-52　2008/01

    ISSN： 0893-2174

  90. Functional properties and regional differences of human masseter motor units related to three-dimensional bite force Peer-reviewed

    Ogawa T, Kawata T, Tsuboi A, Hattori Y, Watanabe M, Sasaki K

    JOURNAL OF ORAL REHABILITATION　33　(10)　729-740　2006/10

    DOI： 10.1111/j.1365-2842.2006.01617.x 　

    ISSN： 0305-182X

  91. Outer shape changes of human masseter with contraction by ultrasound morphometry. International-journal Peer-reviewed

    Kubo K, Kawata T, Ogawa T, Watanabe M, Sasaki K.

    Archives of oral biology　51　(2)　146-53　2006/02

    DOI： 10.1016/j.archoralbio.2005.06.009 　

    ISSN： 0003-9969

  92. Relationships between functional properties of masseter motor units and 3-D bite force Peer-reviewed

    Ogawa T, Kawata T, Tsuboi A, Hattori Y, Watanabe M, Sasaki K

    International Congress Series　1284　43-48　2005/09

    DOI： 10.1016/j.ics.2005.07.068 　

    ISSN： 0531-5131

  93. Ultrasonographic analysis of outer shape changes of human masseter with contraction Peer-reviewed

    Kubo K, Kawata T, Ogawa T, Watanabe M, Sasaki K.

    International Congress Series　1284　63-64　2005/09

    DOI： 10.1016/j.ics.2005.07.034 　

    ISSN： 0531-5131

  94. The effects of RPD wearing on periodontal conditions of abutment and non-abutment teeth Peer-reviewed

    Chiba T, Kawata T, Koyama S, Gorai S, Toki N, Atsumi T, Okayama K, Sasaki H, Noji M, Ogawa T, Inai T, Kimura K, Watanabe M, Sasaki K

    International Congress Series　1284　69-70　2005/09

    DOI： 10.1016/j.ics.2005.07.002 　

    ISSN： 0531-5131

  95. 超音波画像を用いた咬筋の収縮様相

    久保 圭, 川田 哲男, 小川 徹, 渡辺 誠, 佐々木 啓一

    日本顎口腔機能学会雑誌　9　(2)　214-215　2003/04

    Publisher: 日本顎口腔機能学会

    DOI： 10.7144/sgf.9.214 　

    ISSN： 1340-9085

    eISSN： 1883-986X

    More details Close

    健常者5名(平均26.8歳)を対象に,超音波プローブの座標を規定して走査した超音波画像上で咬筋の厚さの多点計測を行った.咬筋の厚さの最大値は安静時12.7±1.0mm,最大随意噛み締め(MVC)時15.7±1.1mmであった.安静時に厚さが最大の部位は中央から後上方,MVC時は上下的中央1/3の位置に存在した.安静時とMVC時を比較すると,厚さはほぼ全部位で変化していた.変化量は部位により異なり,増加する部位と減少する部位があった.減少する部位は主に筋付着部で,厚さ変化量の最大値は6.1±1.7mmであった.安静時厚さとMVC時厚さ,MVC厚さと厚さ変化量は各被験者で相関が認められたが,厚さ変化量と安静時厚さとの間には多くの被験者で相関がなかった.安静時に厚さが最大の部位に対し,MVC時に厚さが最大の部位は同じ高さか下方に,厚さ変化量が最大の部位は前方に位置した.MR画像から計測した厚さは,超音波画像から計測した厚さより平均2.0mm大きかった

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Misc. 108

  1. Piezo1 Gene Activation Enhances Osteogenesis and Implant Integration Under Mechanical Stimulation

    Hu Longshuang, 根本昌代, Xie Ziqi, 天雲太一, 重光竜二, 小川徹, 鈴木治, 依田信裕

    公益社団法人 日本補綴歯科学会 令和７年度 東北・北海道支部学術大会　2025/10/05

  2. 異なる食品特性が健常若年成人および健常高齢者の 咀嚼・嚥下機能に与える影響

    小出理絵, 小川 徹, 成原大衣智, 小峰英也, 互野 亮, 庄原健太, 依田信裕

    公益社団法人 日本補綴歯科学会 令和７年度 東北・北海道支部学術大会　2025/10/05

  3. Piezo1の強制発現による機械刺激応答を介した骨形成

    根本 昌代, 天雲 太一, 重光 竜二, 鈴木 治, 小川 徹, 依田 信裕

    公益社団法人日本補綴歯科学会 第134回学術大会　2025/05/17

  4. MR拡散テンソル画像を応用した咬筋および内・外側翼突筋内部の拡散異方性解析

    木之村史織, 菅野武彦, 小川 徹, 佐々木啓一, 依田信裕

    公益社団法人日本補綴歯科学会 第134回学術大会　2025/05

  5. グミの特性が健常高齢者の咀嚼・嚥下機能に与える 影響に関する影響

    小出理絵, 小川 徹, 成原大衣智, 小峰英也, 互野 亮, 庄原健太, 依田信裕

    日本顎口腔機能学会 第73回学術大会　2025/04/13

  6. グミの特性が健常若年成人の咀嚼・嚥下機能に与える影響

    小出理絵, 小川 徹, 成原大衣智, 小峰英也, 互野 亮, 庄原健太, 依田信裕

    日本顎口腔機能学会 第72回学術大会　2024/12

  7. 3Dプリント材を用いて光造形したOSA用OAの適合性と維持力に関する検討

    廣嶋 なみき, 原田 貴之, 小川 徹

    第23回 日本睡眠歯科学会学術集会(徳島)　2024/11

  8. 就寝前の飲酒習慣による軽度閉塞性睡眠時無呼吸に対するOA療法の一症例

    成原大衣智, 小川 徹, 互野 亮, 依田信裕

    第23回日本睡眠歯科学会学術集会(徳島）　2024/11

  9. 口腔機能低下症患者に対する新規パルス磁気刺激装置の舌骨挙上への影響に関する研究

    砂田慶一, 白石 成, 日原大貴, 小川徹, 佐々木啓一

    令和6年度 日本補綴歯科学会 東北・北海道支部学術大会　2024/10/06

  10. 歯科インプラントの早期荷重要件に関わる非臨床評価法の検討

    日原大貴, 小川 徹, 佐々木啓, 依田信裕

    令和6年度 日本補綴歯科学会 東北・北海道支部学術大会　2024/10/06

  11. 健常若年成人においてグミの特性が咀嚼・嚥下機能に与える影響

    小出理絵, 小川 徹, 小峰英也, 互野 亮, 庄原健太, 日原大貴, 金髙弘恭, 依田信裕

    日本咀嚼学会 第35回学術大会　2024/09/14

  12. 拡散テンソル画像を応用した内・外側翼突筋筋線維走行の三次元解析

    木之村史織, 小川 徹, 菅野武彦, 庄原健太, 佐々木啓一, 江草 宏, 依田信裕

    日本補綴歯科学会第133回学術大会　2024/07

  13. 高齢者の口腔・認知の両機能を向上させる訓練方法：二重盲検RCTによる効果検証

    阿部真澄, 野内 類, 小川 徹, 白石 成, 日原大貴, 豊岡継泰, 土井千章, 檜山 聡, 佐々木啓一, 江草 宏, 依田信裕

    日本補綴歯科学会第133回学術大会　2024/07

  14. リン酸カルシウム遺伝子導入剤のチタン表面への電気的付着効果に関する検討

    岩渕 太人, 天雲 太一, 小川 徹, 佐々木 啓一

    日本補綴歯科学会第133回学術大会　2024/07

  15. 国民皆歯科健診に向けた歯周病発見AIの検証結果について

    土井 千章, 日原大貴, 小川徹, 互野亮, 天雲太一, 竹内研時, 小坂健, 阿部真澄, 千葉智弘, 成原大衣智, 山川蒼平, 渡邉妙絵, 長谷川峻己, 田辺守志, 荒木尊士, 長久保諒輔, 長竹一樹, 豊岡継泰, 髙木唯子, 仲佐昭彦, 古屋大和, 福士浩, 由井祥平, 檜山聡, 飯久保正弘, 佐々木啓一

    第8回 歯科人工知能(AI)研究会　2024/06

  16. 医療機器プログラムとしての歯周病発見AIアプリケーションの開発

    日原大貴, 土井 千章, 小川 徹, 山川 蒼平, 互野 亮, 豊岡 継泰, 長竹 一樹, 髙木 唯子, 仲佐 昭彦, 山本 直樹, 河田 隆弘, 古屋 大和, 竹内 研時, 天雲 太一, 阿部 真澄, 千葉 智弘, 成原 大衣智, 依田 信裕, 小坂 健, 飯久保 正弘, 檜山 聡, 佐々木 啓一

    第8回 歯科人工知能(AI)研究会　2024/06

  17. 医用材料応用へ向けた100％セルロースナノファイバーの生物学的安全性に関する検討

    山田有紀江, 小川徹, 洪光, 小出理絵, 天雲太一, 橋場洋美, 稲用亨, 謝子琪, 濱田泰三, 佐々木啓一

    第16回日本義歯ケア学会学術大会　2024/02

  18. 口腔顔面痛患者における中枢神経感作の特徴

    西須大徳、日原大貴、小川徹、牛田享宏、西原真理

    第45回日本疼痛学会　2023/12

  19. Analysis of muscle fiber orientation in the human medial pterygoid muscle using diffusion tensor imaging

    2023/11/05

  20. 噛みしめに対するスタビリゼーションアプライアンスおよび外傷予防のマウスガードを装着した登山・スキー愛好家の一例

    小川 徹

    第34回日本スポーツ歯科医学会学術大会　2023/11

  21. 多数歯う蝕および部分欠損を有する重度閉塞性睡眠時無呼吸に対するOA治療の１例

    成原大衣智, 互野亮, 小川徹

    第22回日本睡眠歯科学会総会・学術集会　2023/10

  22. 感染チタン表面における銀イオンと青色LED処理のヒドロキシラジカル誘発（発生）作用による新規治療法の検討

    岩渕太人, 天雲太一, 小川 徹

    日本歯科理工学会 令和5年度北海道・東北地方会　2023/10

  23. 光造形により製作したOSA用OAの適合性と維持力に関する検討 －OA内面へのスペーサーの付与の影響について－

    廣嶋なみき, 原田貴之, 小川 徹

    日本睡眠学会第45回定期学術集会　2023/09/15

  24. 東北大学病院嚥下治療センター・歯科における筋萎縮性側索硬化症（ALS）患者に対する介入の実態 〜ALSの重症度と口腔機能の関連〜

    互野亮, 白石成, 千葉智大, 砂田慶一, 小川 徹, 小山重人

    日本顎顔面補綴学会第40回学術大会　2023/06

  25. 東北大学病院嚥下治療センターにおける嚥下障害と口腔機能低下の関連性の検討

    白石成, 互野亮, 小宮山貴将, 泉田一賢, 西條佳奈, 小川 徹, 小山重人, 佐々木啓一

    日本補綴歯科学会第132回学術大会　2023/05

  26. Basic Study on the Effect of Silver Ion and Blue LED on Sterilization and Surface Property Restoration of Infected Titanium

    2023/05

  27. セルロースナノファイバーの生物学的安全性および吸水性に関する検討

    山田有紀, 小川 徹, 天雲 太一, 橋場 洋美, 稲用 亨, 謝 子琪, 濱田 泰三, 佐々木 啓一

    日本補綴歯科学会第132回学術大会　2023/05

  28. 若年成人における認知・口腔機能 トレーニング中の脳活動の検証

    阿部真澄, 野内 類, 依田 信裕, 小川 徹, 白石 成, 日原 大貴, 江草 宏, 佐々木 啓一

    日本補綴歯科学会第132回学術大会　2023/05

  29. Shear Wave Elastographyによる慢性・急性疲労を模擬した等尺性筋収縮前後の咬筋弾性特性の評価

    星野拓真, 舩倉智久, 斉藤慎一郎, 木之村史織, 小川 徹, 平田慎之介, 田原麻梨江

    日本顎口腔機能学会 第69回学術大会　2023/04

  30. SWEによる慢性・急性疲労を模擬した等尺性筋収 縮前後の咬筋弾性の評価

    星野拓真, 船倉智久, 田原麻梨江, 齋藤慎一郎, 平田慎之介, 木之村史織, 小川徹, 庄司憲明, 土谷昌広

    令和４年度生体医歯工学共同研究拠点成果報告会　2023/03

  31. 骨造成におけるIGF-1、BMP-2及びVEGFの併用適用の効果について

    天雲太一, 小出理絵, 山口洋史, 宮下牧子, 小川徹, 佐々木啓一

    第44回東北骨代謝・骨粗鬆症研究会　2023/02

  32. 社会実装に向けた ⻭周病発⾒AIの受容性調査結果について

    中山梨奈, 土井千章, 互野亮, 泉田一賢, 日原大貴, 荒木尊士, 豊岡継泰, 古屋大和, 福士浩, 小川徹, 飯久保正弘, 佐々木啓一, 檜山聡

    第5回⽇本⻭科⼈⼯知能研究会　2023/02

  33. 飲み込みやすさに影響を及ぼす味と栄養素に関する検討

    小川徹, 白川仁, 金髙弘恭, 小出理絵

    食学拠点研究スタートアップ支援制度 令和３年度報告会・令和４年度発表会　2022/12

  34. PMMAディスクを用いて乾式/湿式 CAD/CAM 加工したOSA用OAの適合性と維持力に関する検討

    廣嶋なみき, 小川 徹, 原田貴之, 佐々木啓一

    第21回日本睡眠歯科学会学術集会　2022/11

  35. 臼歯部CAD/CAMインレーの適合性に関する基礎的研究

    浅水 啓輔, 小川 徹, 佐々木 啓一

    日本補綴歯科学会第131回学術大会　2022/07

  36. 光学印象及びCAD/CAMシステムを用いて製作したOSAS用OAの適合性および維持力に関する検討

    相澤なみき, 小川徹, 原田貴之, 佐々木啓一

    日本睡眠学会第47回定期学術集会　2022/06

  37. Correction of Mandibular Deviation Using Occlusal Splint in a Case of Mandibular Reconstruction after Hemimandibulectomy

    互野亮, 佐藤奈央子, 泉田一賢, 畠山高徳, 互野亮, 佐藤奈央子, 泉田一賢, 畠山高徳, 白石成, 小坂萌, 依田信裕, 小川徹, 小山重人, 佐々木啓一

    顎顔面補綴　44　(2)　2021/12

    ISSN： 0389-4045

  38. 慢性口腔顔面痛の生涯教育プログラムに資する Evidence based 学習管理システム（Learning Management System）の開発

    臼田頌, 大久保昌和, 大野由夏, 小川徹, 小長谷光, 小見山道, 坂本英治, 島田明子, 築山能大, 松香芳三, 村岡渡, 佐々木啓一

    第40回日本歯科医学教育学会　2021/12

  39. 東北大学病院口腔内科・リエゾンセンターにおける初診患者の動向

    庄司憲明, 千葉雅俊, 永井宏和, 佐藤しづ子, 菅原由美子, 小川 徹, 重光竜二, 岩間亮介, 鈴木飛佳理, 工藤葉子, 安田真久, 水田健太郎, 田中恭恵, 山口哲史, 八幡祥生

    第78回東北大学歯学会　2021/12

  40. Trial of Remote training using Video meeting system and Communication application like Zoom and LINE

    LIN Chih Ting, 天雲太一, 庄原健太, 小出理絵, 小川徹, 佐々木啓一

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　40th (Web)　2021/11

  41. 【世界初!連合印象用ペースト型アルジネート印象材の可能性『ジーシーアローマインジェクション』の評価と臨床活用法】(Part 1)シリコーン印象材に対する優位性

    小川 徹, 重光 竜二, 互野 亮

    補綴臨床　54　(3)　232-239　2021/05

    Publisher: 医歯薬出版(株)

    ISSN： 0018-6341

  42. 臼歯部窩洞への CAD/CAMインレーの適合性について

    浅水啓輔, 佐藤正和, 小川 徹, 佐々木啓一

    一般社団法人日本デジタル歯科学会第12回学術大会　2021/04

  43. デジタル時代に学ぶ 咬合学NEO 顎口腔機能と補綴装置(第4回) 咀嚼と補綴治療・装置(後)

    佐藤 智哉, 小川 徹, 佐々木 啓一

    歯科技工　49　(4)　430-441　2021/04

    Publisher: 医歯薬出版(株)

    ISSN： 0389-1895

  44. デジタル時代に学ぶ 咬合学NEO 顎口腔機能と補綴装置(第3回) 咀嚼と補綴治療・装置(前)

    佐藤 智哉, 小川 徹, 佐々木 啓一

    歯科技工　49　(3)　291-301　2021/03

    Publisher: 医歯薬出版(株)

    ISSN： 0389-1895

  45. Optimization of DTI for masseter muscle fiber visualization

    菅野武彦, 依田信裕, 小川徹, 橋本照男, 庄原健太, 新妻邦泰, 川島隆太, 佐々木啓一

    日本補綴歯科学会誌(Web)　13　2021

    ISSN： 1883-6860

  46. Estimation of muscle fiber orientation in multi-pennate muscle using DTI

    菅野武彦, 依田信裕, 小川徹, 橋本照男, 庄原健太, 新妻邦泰, 川島隆太, 佐々木啓一

    日本顎口腔機能学会学術大会プログラム・事前抄録集　65th　2021

  47. Musculoskeletal Simulation in terms of the mandibular movement

    重光竜二, 小川徹, 佐々木啓一

    日本顎口腔機能学会学術大会プログラム・事前抄録集　65th　2021

  48. 動画解析による顎関節症判定手法の検討

    土井 千章, 荒木 尊士, 池田 大造, 泉田 一賢, 日原 大貴, 小川 徹, 佐々木 啓一

    日本顎関節学会雑誌　32　(Suppl.)　67-67　2020/07

    Publisher: (一社)日本顎関節学会

    ISSN： 0915-3004

    eISSN： 1884-4308

  49. DTIを応用した咬筋内部の筋線維三次元描出および走行解析

    菅野 武彦, 依田 信裕, 小川 徹, 橋本 照男, 新妻 邦泰, 川島 隆太, 佐々木 啓一

    日本補綴歯科学会誌　12　(特別号)　130-130　2020/06

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  50. A study on temporomandibular joint disorders detection method based on video analysis

    土井千章, 土井千章, 荒木尊士, 池田大造, 泉田一賢, 日原大貴, 小川徹, 佐々木啓一

    日本顎関節学会雑誌(Web)　32　2020

    ISSN： 1884-4308

  51. デジタル技術を用いて製作した閉塞型睡眠時無呼吸症用口腔内装置の適合および維持に関する検討

    相澤 なみき,小川 徹,原田 貴之,佐々木 啓一

    第４１回日本歯科技工学会学術大会　2019/10

  52. OA治療のアドヒアランスを考慮した日本のOSA治療

    小川 徹

    睡眠口腔医学　6　(1)　53-53　2019/10

    Publisher: (NPO)日本睡眠歯科学会

    ISSN： 2188-6695

    eISSN： 2433-8524

  53. インプラント埋入後早期のアバットメントスクリューの着脱がオッセオインテグレーションに及ぼす影響 高齢ラットの脛骨インプラントモデルを用いた検討

    庄原 健太, 小川 徹, 宮下 牧子, 伊東 明代, 佐々木 啓一

    日本口腔インプラント学会誌　32　(3)　E178-E179　2019/09

    Publisher: (公社)日本口腔インプラント学会

    ISSN： 0914-6695

    eISSN： 2187-9117

  54. Diffusion tensor imagingを応用した咬筋内部筋線維動態の3次元解析手法の開発

    菅野 武彦, 佐々木 啓一, 小川 徹, 依田 信裕

    日本口腔科学会雑誌　68　(2)　149-149　2019/07

    Publisher: (NPO)日本口腔科学会

    ISSN： 0029-0297

    eISSN： 2185-0461

  55. セルロースナノファイバー成形体への疎水性付与についての検討

    伊藤 多佳男, 山崎 友起子, 小川 徹, 洪 光, 田中 裕之, 橋場 洋美, 相澤 將之, 平田 広一郎, 坂田 英武, 夕田 貞之, 和田 訓, 樋口 鎮央, 濱田 泰三, 佐々木 啓一

    日本補綴歯科学会誌　11　(特別号)　284-284　2019/05

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  56. 睡眠時無呼吸症に対する歯科的アプローチ

    小川 徹

    スポーツ歯学　22　(2)　59-59　2019/02

    Publisher: (一社)日本スポーツ歯科医学会

    ISSN： 1344-140X

  57. 生体材料としての窒素ドープ酸化チタンにおける機能性評価

    岩津実里, 目代貴之, 目代貴之, 川下将一, 川下将一, 小川徹, 佐々木啓一, 庭野吉己, 庭野吉己, 金高弘恭, 金高弘恭

    日本防菌防黴学会年次大会要旨集　46th　2019

  58. ラット脛骨インプラントモデルにおける低強度高周波振動刺激と低出力超音波パルスのインプラント周囲骨形成促進効果に関する検討

    庄原 健太, 小川 徹, 宮下 牧子, 伊東 明代, 佐々木 啓一

    日本口腔インプラント学会学術大会抄録集　48回　117-117　2018/09

    Publisher: (公社)日本口腔インプラント学会

  59. OSAS治療のアドヒアランスを考える-諸外国の事情もふまえて- OA治療のアドヒアランス 国内外の違いと問題点

    小川 徹

    日本睡眠学会定期学術集会プログラム・抄録集　43回　122-122　2018/07

    Publisher: (一社)日本睡眠学会

  60. 睡眠時無呼吸症に対する歯科的アプローチ

    小川 徹

    日本スポーツ歯科医学会学術大会プログラム抄録集　29回　44-44　2018/06

    Publisher: (一社)日本スポーツ歯科医学会

  61. 生体内荷重測定に基づくインプラント生体力学研究の発展と課題

    依田 信裕, 小山 重人, 小川 徹, 松舘 芳樹, 重光 竜二, 川田 哲男, 佐々木 啓一

    日本口腔インプラント学会誌　31　(2)　135-143　2018/06

    Publisher: (公社)日本口腔インプラント学会

    ISSN： 0914-6695

  62. ドキソルビシンのヒト正常口腔ケラチノサイトに対する細胞毒性およびポリフェノール併用の影響

    生 宏, 小川 徹, 庭野 吉己, 佐々木 啓一, 立花 克郎

    Journal of Oral Biosciences Supplement　2017　526-526　2017/09

    Publisher: (一社)歯科基礎医学会

    ISSN： 2187-2333

    eISSN： 2187-9109

  63. Amiloride-enhanced gene transfection of octa-arginine functionalized calcium phosphate nanoparticles

    9　276-276　2017/06

  64. 有床義歯装着者の機能評価のガイドライン(2016改訂版)

    皆木 省吾, 山崎 要一, 矢谷 博文, 志賀 博, 山口 泰彦, 服部 佳功, 吉田 教明, 石垣 尚一, 加藤 均, 三浦 宏之, 荒川 一郎, 岡本 和彦, 小野 高裕, 横山 正起, 岡田 和樹, 小川 徹, 菅沼 岳史, 藤澤 政紀, 沖 和広, 坂口 究, 重本 修伺, 瑞森 崇弘, 小見山 道, 田中 恭恵, 堀 一浩, 渡邉 明, 宮脇 正一, 山田 一尋, 斉藤 一誠, 長谷川 信乃, 早崎 治明, 井上 富雄, 井上 誠, 大川 周治, 川良 美佐雄, 祇園白 信仁, 小林 博, 古谷野 潔, 佐々木 啓一, 田中 昌博, 田村 康夫, 野村 修一, 藤村 哲也, 増田 裕次, 鱒見 進一, 倉持 淳子, 昆 はるか, 櫻井 直樹, 山本 早織, 日本顎口腔機能学会, 日本顎口腔機能学会ガイドライン統括委員会

    日本顎口腔機能学会雑誌　23　(2)　E3-E35　2017/03

    Publisher: 日本顎口腔機能学会

    ISSN： 1340-9085

    eISSN： 1883-986X

  65. 顎関節症患者の機能評価のガイドライン(2016改訂版)

    皆木 省吾, 山崎 要一, 矢谷 博文, 志賀 博, 山口 泰彦, 服部 佳功, 吉田 教明, 石垣 尚一, 加藤 均, 三浦 宏之, 荒川 一郎, 岡本 和彦, 小野 高裕, 横山 正起, 岡田 和樹, 小川 徹, 菅沼 岳史, 藤澤 政紀, 沖 和広, 坂口 究, 重本 修伺, 瑞森 崇弘, 小見山 道, 田中 恭恵, 堀 一浩, 渡邉 明, 宮脇 正一, 山田 一尋, 斉藤 一誠, 長谷川 信乃, 早崎 治明, 井上 富雄, 井上 誠, 大川 周治, 川良 美佐雄, 祇園白 信仁, 小林 博, 古谷野 潔, 佐々木 啓一, 田中 昌博, 田村 康夫, 野村 修一, 藤村 哲也, 増田 裕次, 鱒見 進一, 倉持 淳子, 昆 はるか, 櫻井 直樹, 山本 早織, 日本顎口腔機能学会, 日本顎口腔機能学会ガイドライン統括委員会

    日本顎口腔機能学会雑誌　23　(2)　E37-E109　2017/03

    Publisher: 日本顎口腔機能学会

    ISSN： 1340-9085

    eISSN： 1883-986X

  66. 口腔咽頭領域OSA研究Update 2016 下顎前方移動時の舌形態 閉塞性睡眠時無呼吸症に対する口腔内装置の治療効果予測

    小川 徹

    日本睡眠学会定期学術集会プログラム・抄録集　41回　152-152　2016/07

    Publisher: (一社)日本睡眠学会

  67. 下顎無歯顎に対するインプラント2本支台オーバーデンチャーのアタッチメントに関する生体力学的研究

    虻江 勝, 松舘 芳樹, 依田 信裕, 小川 徹, 佐々木 啓一

    日本口腔インプラント学会誌　28　(特別号)　243-243　2015/08

    Publisher: (公社)日本口腔インプラント学会

    ISSN： 0914-6695

    eISSN： 2187-9117

  68. 閉塞型睡眠時無呼吸症候群治療の現状と今後の展開 Interdisciplinary treatment approachのなかでの歯科補綴の役割

    山内 基雄, 犬飼 周佑, 小川 徹

    日本補綴歯科学会誌　7　(特別号)　109-109　2015/05

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  69. 骨粗鬆症インプラントモデルにおける低強度高周波振動刺激とPTHの骨形成促進効果

    柴本 彩, 小川 徹, Joke Duyck, Ignace Naert, 佐々木 啓一

    日本補綴歯科学会誌　7　(特別号)　186-186　2015/05

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  70. インプラント支台パーシャルオーバーデンチャーの荷重負担様相に関する生体力学的検討

    松舘 芳樹, 依田 信裕, 難波 正英, 小針 啓司, 小川 徹, 佐々木 啓一

    日本補綴歯科学会誌　5　(特別号)　164-164　2013/05

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  71. 固定性インプラント補綴における支台インプラントの本数・植立位置とインプラント荷重との関連 生体内測定と模型上測定の比較

    依田 信裕, 小針 啓司, 班 兆陽, 孫 堅, 郡司 良律, 小川 徹, 川田 哲男, 佐々木 啓一

    日本顎口腔機能学会雑誌　19　(2)　204-205　2013/02

    Publisher: 日本顎口腔機能学会

    DOI： 10.7144/sgf.19.204 　

    ISSN： 1340-9085

    eISSN： 1883-986X

  72. NaF-PETを用いた義歯床下のメカノバイオロジカルな骨代謝活性に関する研究

    末永 華子, 横山 政宣, 依田 信裕, 小川 徹, 山口 慶一郎, 佐々木 啓一

    日本歯科医師会雑誌　65　(5)　666-666　2012/08

    Publisher: (公社)日本歯科医師会

    ISSN： 0047-1763

  73. In Vivo三次元咬合力データに基づくインプラント補綴症例の生体力学的検討

    依田 信裕, 重光 竜二, 小針 啓司, 郡司 良律, 孫 堅, 川田 哲男, 小川 徹, 佐々木 啓一

    日本歯科医師会雑誌　65　(5)　668-668　2012/08

    Publisher: (公社)日本歯科医師会

    ISSN： 0047-1763

  74. 生体内荷重データを用いたFEA解析に基づくインプラント周囲骨内応力に関する検討

    重光 竜二, 松本 哲哉, 水戸 武彦, 依田 信裕, 小川 徹, 佐々木 啓一

    日本歯科医師会雑誌　65　(5)　668-668　2012/08

    Publisher: (公社)日本歯科医師会

    ISSN： 0047-1763

  75. 固定性補綴装装置の支台インプラント本数・位置と荷重との関連に関する模型解析

    小針 啓司, 孫 堅, 依田 信裕, 小川 徹, 佐々木 啓一

    日本補綴歯科学会誌　4　(特別号)　196-196　2012/05

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  76. 固定性インプラント補綴における支台インプラントの本数・植立位置とインプラント荷重との関連 生体内計測に基づく解析

    小針 啓司, 依田 信裕, 郡司 良律, 小川 徹, 川田 哲男, 佐々木 啓一

    日本顎口腔機能学会雑誌　18　(1)　52-53　2011/10

    Publisher: 日本顎口腔機能学会

    DOI： 10.7144/sgf.18.52 　

    ISSN： 1340-9085

    eISSN： 1883-986X

  77. 低強度・高周波振動刺激の骨形成活性効果

    小川 徹

    東北大学歯学雑誌　30　(1)　32-32　2011/06

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  78. 低強度・高周波振動刺激によるインプラント周囲骨の骨形成活性化に関する研究

    小川 徹, 張 暁磊, Ignace Naert, 佐々木 啓一, Joke Duyck

    日本補綴歯科学会誌　3　(特別号)　117-117　2011/05

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  79. 可撤性部分床義歯装着患者の残存歯歯周組織状態に対するメインテナンスケアの効果

    冨士 岳志, 花渕 静, 小山 重人, 依田 信裕, 佐々木 具文, 横山 政宣, 小川 徹, 塙 総司, 佐藤 奈央子, 重光 竜二, 末永 華子, 折居 雄介, 赤塚 亮, 白石 成, 竹内 裕尚, 佐々木 啓一

    日本補綴歯科学会誌　3　(特別号)　207-207　2011/05

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  80. Modified spike-triggered averaging techniqueと表面アレイ電極による咬筋運動単位活動の筋電図学的分析

    関根 直輝, 塙 総司, 小川 徹, 佐々木 啓一

    日本補綴歯科学会誌　3　(1)　E25-E25　2011/01

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  81. 後向きコホート調査による可撤性部分床義歯症例の長期経過

    冨士 岳志, 小山 重人, 依田 信裕, 伊奈 慶典, 佐々木 具文, 羽鳥 弘毅, 横山 政宣, 小川 徹, 塙 総司, 佐藤 奈央子, 重光 竜二, 末永 華子, 折居 雄介, 赤塚 亮, 白石 成, 竹内 裕尚, 佐々木 啓一

    みちのく歯学会雑誌　41　(1-2)　73-74　2010/12

    Publisher: 東北地区歯科医学会

    ISSN： 0385-0099

  82. OSAS治療用オーラルアプライアンスに付与する下顎位に関する検討

    伊藤 利実, 小川 徹, 鈴木 祐, 松田 倫和, 佐々木 啓一

    日本顎口腔機能学会雑誌　15　(2)　166-167　2009/02

    Publisher: 日本顎口腔機能学会

    DOI： 10.7144/sgf.15.166 　

    ISSN： 1340-9085

    eISSN： 1883-986X

  83. In vivo analysis of the 3-D force on implants supporting fixed prostheses

    Gunji Y, Yoda N, Chiba T, Ogawa T, Kuriyagawa T, Sasaki K

    Interface Oral Health Science　2009

  84. Study for Occlusal Function of the Autotransplanted Teeth

    SUZUKI T, OGAWA T, ITO T, GUNJI Y, KASAHARA S, MORI S, SASAKI K

    52　(117)　101-101　2008/06/06

  85. 可撤性部分床義歯の使用状況に影響を及ぼす因子に関する臨床統計学的検討

    牛来 慎太郎, 小山 重人, 千葉 貴大, 小川 徹, 羽鳥 弘毅, 佐々木 啓一

    日本補綴歯科学会雑誌　52　(2)　126-134　2008/04

    Publisher: (公社)日本補綴歯科学会

    DOI： 10.2186/jjps.52.126 　

    ISSN： 0389-5386

  86. 自家移植歯の歯根膜触・圧覚と咬合力負担能力に関する研究

    鈴木 祐, 小川 徹, 伊藤 利実, 郡司 良律, 笠原 紳, 森 士朗, 佐々木 啓一

    日本顎口腔機能学会雑誌　14　(2)　104-105　2008/02

    Publisher: 日本顎口腔機能学会

    DOI： 10.7144/sgf.14.104 　

    ISSN： 1340-9085

    eISSN： 1883-986X

  87. レスト設置形態と部分床義歯床下圧力分野 生体内測定による検討

    末永 華子, 久保 圭, 重光 竜二, 依田 信裕, 小川 徹, 川田 哲男, 佐々木 啓一

    日本顎口腔機能学会雑誌　14　(2)　108-109　2008/02

    Publisher: 日本顎口腔機能学会

    DOI： 10.7144/sgf.14.108 　

    ISSN： 1340-9085

    eISSN： 1883-986X

  88. 可撤性部分床義歯の受容に関与する因子および満足度の検討

    小山 重人, 渥美 知洋, 羽鳥 弘毅, 小川 徹, 佐々木 具文, 横山 政宣, 久保 圭, 塙 総司, 門脇 健司, 牛来 慎太郎, 川田 哲男, 木村 幸平, 渡辺 誠, 佐々木 啓一

    日本補綴歯科学会雑誌　51　(116回特別)　139-139　2007/05

    Publisher: (公社)日本補綴歯科学会

    ISSN： 0389-5386

    eISSN： 1883-177X

  89. 可撤性部分床義歯装着患者における使用状況と残存歯歯周組織状態の経年的変化

    門脇 研司, 小山 重人, 川田 哲男, 佐々木 具文, 羽鳥 弘毅, 小川 徹, 横山 政宣, 久保 圭, 塙 総司, 伊奈 慶典, 重光 竜二, 末永 華子, 鈴木 祐, 加賀谷 恵理, 木村 幸平, 渡辺 誠, 佐々木 啓一

    日本補綴歯科学会雑誌　51　(2)　385-385　2007/04

    Publisher: (公社)日本補綴歯科学会

    ISSN： 0389-5386

    eISSN： 1883-177X

  90. 下顎臼歯の歯根膜触・圧覚と咬合力・咬合接触面積との関連

    小川 徹, 大石 直, 鈴木 祐, 伊藤 利実, 井上 美香, 川田 哲男, 佐々木 啓一

    日本顎口腔機能学会雑誌　13　(2)　126-127　2007/02

    Publisher: 日本顎口腔機能学会

    DOI： 10.7144/sgf.13.126 　

    ISSN： 1340-9085

  91. 4.Relationship between occlusal rest design and pressure distribution under denture base of removable partial denture in vivo

    Suenaga Hanako, Kubo K, Shigemitsu R, Yoda N, Ogawa T, Kawata T, Sasaki K

    (39)　22-23　2007

    Publisher: 日本顎口腔機能学会

  92. オーバーデンチャー支台インプラント荷重の三次元解析システムの開発とその生体応用

    依田 信裕, 川田 哲男, 小川 徹, 久保 圭, 末永 華子, 重光 晃二, 厨川 常元, 佐々木 啓一

    日本補綴歯科学会雑誌　50　(115回特別)　94-94　2006/07

    Publisher: (公社)日本補綴歯科学会

    ISSN： 0389-5386

    eISSN： 1883-177X

  93. 部分床義歯床下粘膜面に加わる圧力の生体内多点同時測定

    末永 華子, 川田 哲男, 久保 圭, 重光 竜二, 依田 信裕, 小川 徹, 佐々木 啓一

    日本補綴歯科学会雑誌　50　(115回特別)　110-110　2006/07

    Publisher: (公社)日本補綴歯科学会

    ISSN： 0389-5386

    eISSN： 1883-177X

  94. 機能時に歯に加わる圧縮力および引張力の生体内三次元測定

    川田 哲男, 依田 信裕, 川口 威史, 末永 華子, 小川 徹, 厨川 常元, 佐々木 啓一

    日本補綴歯科学会雑誌　50　(115回特別)　133-133　2006/07

    Publisher: (公社)日本補綴歯科学会

    ISSN： 0389-5386

    eISSN： 1883-177X

  95. 多数歯欠損のOSAS症例に対するオーラルアプライアンス治療の検討

    小川 徹, 伊藤 利実, 鈴木 祐, 真柳 弦, 南 匠, 島内 英俊, 川田 哲男, 佐々木 啓一

    日本補綴歯科学会雑誌　50　(115回特別)　206-206　2006/07

    Publisher: (公社)日本補綴歯科学会

    ISSN： 0389-5386

    eISSN： 1883-177X

  96. 6.Relationship between bite force, occlusal contact area and periodontal mechano-sensation of human lower premolars and molars

    OGAWA T., OISHI N., SUZUKI T., ITO T., INOUE M., KAWATA T., SASAKI K.

    (37)　20-21　2006

    Publisher: 日本顎口腔機能学会

  97. 可撤性部分床義歯装着患者における残存歯歯周組織状態

    門脇 研司, 千葉 貴大, 小山 重人, 加賀谷 恵理, 稲井 哲司, 川田 哲男, 佐々木 具文, 羽鳥 弘毅, 小川 徹, 横山 政宣, 足立 元樹, 伊藤 利実, 鈴木 祐子, 依田 信裕, 木村 幸平, 渡辺 誠, 佐々木 啓一

    日本補綴歯科学会雑誌　50　(1)　138-138　2006/01

    Publisher: (公社)日本補綴歯科学会

    ISSN： 0389-5386

    eISSN： 1883-177X

  98. 部分床義歯粘膜面に加わる圧力の生体内多点同時測定

    久保 圭, 川田 哲男, 南 文将, 重光 竜二, 末永 華子, 依田 信裕, 小川 徹, 佐々木 啓一

    日本補綴歯科学会雑誌　50　(1)　141-141　2006/01

    Publisher: (公社)日本補綴歯科学会

    ISSN： 0389-5386

    eISSN： 1883-177X

  99. 部分床義歯粘膜面における生体内圧力多点同時測定

    久保 圭, 川田 哲男, 南 文将, 重光 竜二, 末永 華子, 依田 信裕, 小川 徹, 佐々木 啓一

    日本補綴歯科学会雑誌　49　(114回特別)　168-168　2005/10

    Publisher: (公社)日本補綴歯科学会

    ISSN： 0389-5386

    eISSN： 1883-177X

  100. 超音波画像計測に基づくヒト咬筋の収縮に伴う外形変化

    久保 圭, 川田 哲男, 小川 徹, 渡辺 誠, 佐々木 啓一

    生体医工学　43　(2)　329-329　2005/06

    Publisher: 日本生体医工学会

    ISSN： 1347-443X

  101. 歯に加わる荷重の生体内三次元測定

    川田 哲男, 依田 信裕, 小川 徹, 末永 華子, 厨川 常元, 佐々木 啓一

    生体医工学　43　(2)　330-330　2005/06

    Publisher: 日本生体医工学会

    ISSN： 1347-443X

    eISSN： 1881-4379

  102. 可撤性部分床義歯装着患者の使用状況と満足度に関する検討

    渥美 知洋, 千葉 貴大, 小山 重人, 稲井 哲司, 川田 哲男, 佐々木 具文, 羽鳥 弘毅, 小川 徹, 牛来 慎太郎, 岡山 啓昌, 佐々木 洋人, 野地 美代子, 笠原 紳, 依田 正信, 木村 幸平, 玉澤 佳純, 菊池 雅彦, 渡辺 誠, 佐々木 啓一

    日本補綴歯科学会雑誌　48　(5)　885-885　2004/12

    Publisher: (公社)日本補綴歯科学会

    ISSN： 0389-5386

  103. Regional differences in motor unit behavior within the superficial masseter.

    T. Ogawa, T. Kawata, A. Tsuboi, Y. Hattori, M. Watanabe, K. Sasaki

    JOURNAL OF DENTAL RESEARCH　82　B94-B94　2003/06

    ISSN： 0022-0345

  104. 【目で見る咬合の基礎知識】 咀嚼筋

    小川 徹, 佐々木 啓一

    歯科技工　別冊　(目で見る咬合の基礎知識)　152-153　2002/06

    Publisher: 医歯薬出版(株)

    ISSN： 0389-1895

  105. Differences in motor unit behaviors between superficial and deep masseter.

    T Ogawa, T Kawata, A Tsuboi, Y Hattori, M Watanabe, K Sasaki

    JOURNAL OF DENTAL RESEARCH　81　A457-A457　2002/03

    ISSN： 0022-0345

  106. Behaviour of masseter motor units related to 3-D bite force

    T Ogawa, T Kawata, K Sasaki, Y Hattori, M Watanabe

    JOURNAL OF DENTAL RESEARCH　80　(4)　1326-1326　2001/04

    ISSN： 0022-0345

  107. 三次元こう合力に基づくこう筋運動単位活動に関する検討

    小川徹, 川田哲男, 岩松正明, 坪井明人, 服部佳功, 稲井哲司, 佐々木啓一, 渡辺誠

    日本補綴歯科学会学術大会プログラム・抄録集　104th　70　2000/11

    ISSN： 1883-4426

  108. 三次元咬合力に基づく咬筋運動単位活動に関する検討

    小川 徹, 川田 哲男, 岩松 正明, 坪井 明人, 服部 佳功, 稲井 哲司, 佐々木 啓一, 渡辺 誠

    日本補綴歯科学会雑誌　44　(104回特別)　70-70　2000/11

    Publisher: (公社)日本補綴歯科学会

    ISSN： 0389-5386

Show all ︎Show first 5

Books and Other Publications 7

  1. 口腔顔面痛の診断と治療ガイドブック 第3版

    医歯薬出版株式会社　2023

  2. 口腔顔面痛の診断と治療ガイドブック 第3版

    医歯薬出版株式会社　2023

  3. 【世界初!連合印象用ペースト型アルジネート印象材の可能性『ジーシーアローマインジェクション』の評価と臨床活用法】(Part 1)シリコーン印象材に対する優位性

    小川 徹, 重光 竜二, 互野 亮

    補綴臨床 2021年5月 医歯薬出版(株) 54巻3号231-239　2021/05

  4. デジタル時代に学ぶ 咬合顎NEO－顎口腔機能と補綴装置，咀嚼と補綴治療・装置

    佐藤智哉, 小川 徹, 佐々木啓一

    医歯薬出版　2021/04

  5. 宮城の医療と健康 vol.6 あなたのいびきは大丈夫？ー睡眠時無呼吸症への歯科的対応ー

    小川 徹(P125-127)

    河北新報社　2018/10

    ISBN: 9784905483106

  6. パーシャルデンチャー治療 失敗回避のためのポイント47 －診断・前処置・印象・設計・応急処置と術後管理の問題解決法－

    山下秀一郎, 佐々木啓一

    クインテッセンス出版株式会社　2017

  7. 新しい印象材アローマインジェクションを臨床に活かす 症例から読み解く可能性

    佐々木啓一, 小川 徹, 亀田行雄, 佐氏英介, 片岡康弘

    GC CIRCLE, No.178, 2021-7, 4-12

Show all Show first 5

Presentations 76

  1. Preliminary study on muscular tissue characterization using continuous shear wave elastography

    Tabaru M, Tano N, Ogawa T, Koda R, Yamakoshi Y

    2025/09/24

  2. 臨床推論はどう教えられているか？ ─アンケートから探る歯学教育の現状と課題─ Invited

    小川 徹

    第38回日本口腔診断学会学術大会 シンポジウム１（口腔顔面痛学会コラボレーション企画 ）　2025/09/06

  3. 睡眠・ブラキシズム・無呼吸と顎関節症の関連

    小川 徹

    第38回日本顎関節学会学術大会 シンポジウム ５　2025/07/12

  4. Neck Flute Design: Enhancing Implant Stability and Osseointegration

    Ziqi Xie, Toru Ogawa, Shobara Kenta, Nobuhiro Yoda

    2025 IADR/PER General Session & Exhibition　2025/06/26

  5. Effect of Implant Abutment Connection Designs and Cyclic Loading on Screw Stability in Dental Implants: A Systematic Review

    Sara Reda Sammour, Ziqi Xie, Toru Ogawa, Nobuhiro Yoda

    2025 IADR/PER General Session & Exhibition　2025/06/26

  6. 単純ではない閉塞性睡眠時無呼吸症の治療 －疾患多様性とアドヒアランスを踏まえた包括的アプローチ－ Invited

    小川 徹

    R7年度 仙台歯科医師会学術講演会　2025/04/20

  7. 歯科臨床でみられる運動障害とボツリヌス療法の基礎的メカニズム Invited

    小川 徹

    一般社団法人日本顎関節学会 第61回学術講演会　2025/03/23

  8. 症例から学ぶ -欠損補綴・咬合治療のダイバーシティ- Invited

    小川 徹

    令和6年 東北大学歯学部同窓会 卒後研修会　2024/11/10

  9. Analysis of muscle fiber orientation in the human medial and lateral pterygoid muscles using diffusion tensor imaging

    Shiori Kinomura, Toru Ogawa, Kenta Shobara, Takehiko Sugano, Kuniyasu Niizuma, Keiichi Sasaki, Nobuhiro Yoda

    2024 Scientific Annual Meeting of ADEAP; CAMPUS Asia Plus in Dentistry International Symposium 2024　2024/10/19

  10. Fabrication of functionalized titanium surfaces with calcium phosphate for effective gene transfection

    Taito Iwabuchi, Taichi Tenkumo, Toru Ogawa, Keiichi Sasaki, Nobuhiro Yoda

    2024 Scientific Annual Meeting of ADEAP; CAMPUS Asia Plus in Dentistry International Symposium 2024　2024/10/19

  11. 閉塞性睡眠時無呼吸症の基本から臨床－疾患多様性を踏まえた歯科的アプローチ－ Invited

    小川徹

    日本臨床歯科学会SJCD 東北支部 2024年度 第3回オープン学術大会　2024/08/25

  12. 顎関節症と鑑別が必要な顎口腔領域の不随意運動，歯科臨床でみられる運動障害 Invited

    小川 徹

    第37回一般社団法人日本顎関節学会学術大会，日本口腔顔面痛学会合同シンポジウム　2024/07/14

  13. PCA-based kinematic classification of mandibular movements from TMD patients

    Ryuji Shigemitsu, Toru Ogawa, John Rasmussen

    2024/07/07

  14. Effectiveness of dental implants indicated for early-loading protocols on peri-implant bone healing: An animal study

    Toru Ogawa, Sheng Zheng, Masayo Nemoto, Xie Ziqi, Hu Longshuang, Kenta Shobara, Hiroki Hihara, Hiroyasu Kanetaka

    Pacific Coast Society for Prosthodontics (PCSP) 89th annual Meeting　2024/06/21

  15. Effects of food characteristics on chewing and swallowing function in healthy young adults.

    Rie Koide, Toru Ogawa, Taichi Narihara, Hideya Komine, Ryo Tagaino, Kenta Shobara, Hiroki Hihara, Hiroyasu Kanetaka

    Pacific Coast Society for Prosthodontics (PCSP) 89th annual Meeting　2024/06/21

  16. Clinical application of Sticky-bone combined with Advanced Platelet-Rich Fibrin membrane for postextraction socket preservation: a prospective study

    2024/03

  17. The Socket-Shield Technique: Guided Surgery and Immediate Implant Loading-4-years Follow-up

    Sheng Zheng, Ziyu Zhou, Toru Ogawa

    The 21st Annual meeting of APIS (Asian Pacific Implant Society)　2024/03

  18. Partial orthodontic treatment with miniscrew in the maxillary tuberosity before restoration 4-years Follow-up

    2024/03

  19. Comparative Histological and Radiological Analysis of Four Types of Bone Augmentation Implants in Rabbit Tibial Non-Critical Bone Defect Model

    2024/03

  20. 教育セミナー２「Red Flag を探せ！」症例④ 「入れ歯を作りたいが，口が開けられない」

    小川 徹

    第28回一般社団法人日本口腔顔面痛学会学術大会　2023/11/19

  21. Dental approach for obstructive sleep apnea therapy using oral appliances Invited

    Toru OGAWA

    2023/11/19

  22. Effect of growth factor cocktails for bone augmentation of mouse

    Taichi Tenkumo, Rie Koide, Toru Ogawa, Hirofumi Yamaguchi, Shigeki Suzuki, Makiko Miyashita, Keisuke Nakamura, Nobuhiro Yoda, Han Wang, Keiichi. Sasaki

    Interface Summer Seminar 2023, The 18th International Workshop on Biomaterials in Interface Science　2023/08

  23. 多様な欠損補綴症例に応じた 補綴・咬合治療のオプションとその要点

    小川 徹

    奥羽大学歯学部宮城県同窓会 令和5年度 第一回 学術講演会　2023/05/13

  24. Effect of taste and nutrients on ease of swallowing in elderly adults – An ongoing study

    Rie Koide, Toru Ogawa, Hideya Komine, Hiroyasu Kanetaka

    CAMPUS Asia Plus in Dentistry (CA+inD) International Symposium 2023, 2023 Scientific Annual Meeting of Association for Dental Education, Asia Pacific (ADEAP)　2023/01/29

  25. Application of microwave-assisted TiN coating synthesized on implant abutment alloys

    2022/06/24

  26. Tenomodulin induce bone formation activity in combination with calcium phosphate

    Wang Han, Taichi Tenkumo, Keisuke Nakamura, Eiji Nemoto, Toru Ogawa, Keiichi. Sasaki

    2021/07/21

  27. 【世界初!連合印象用ペースト型アルジネート印象材の可能性『ジーシーアローマインジェクション』の評価と臨床活用法】(Part 1)シリコーン印象材に対する優位性

    小川 徹, 重光 竜二, 互野 亮

    補綴臨床　2021/05

  28. Antibacterial Activity of Nitrogen-Doped Titanium Dioxide Under Visible Light

    Iwatsu M, Mokudai T, Kawashita M, Ogawa T, Kanetaka H, Sasaki K

    The 4th International Symposium on Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development(iLIM-4) in conjunction with T14th International Workshop on Biomaterials in Interface Science Innovative Research for Biosis-Abiosis Intelligent Interface Seminar 2019　2019/10

  29. Electromyographic Analysis of Masseter Motor Unit Activity using Multi-Channel Surface Array-Electrodes with Modified Spike-Triggered Averaging Technique

    Ogawa T, Sekine N, Miyashita M, Hanawa S, Sasaki K

    ICP-EPA Meeting　2019/09

  30. 睡眠時無呼吸症に対する歯科的アプローチ

    小川 徹

    スポーツ歯学; 教育講演　2019/02

  31. In vivo Study of Functional Compartmentalization of the Masseter Muscle: A Methodological Pilot Study

    Sugano T, Yoda N, Ogawa T, Sasaki K

    2019/01

  32. 米沢市立病院に開設した歯科外来の活動について

    小川 徹

    第22回おくちのさわやか週間市民講演会　2018/11

  33. Visible light-induced antimicrobial activity of nitrogen-doped TiO2 on Ti treated with NaOH, hot water, and ammonia atmospheric heat treatment

    Iwatsu M, Mokudai T, Kawashita M, Watanabe T, Ogawa T, Kanetaka H, Sasaki K

    2018/10

  34. Visible light-induced antimicrobial activity of N-doped TiO2 on Ti substrates

    Iwatsu M, Ogawa T, Mokudai T, Kanetaka H, Kawashita M, Watanabe T, Sasaki K

    2018/10

  35. Resonance frequency analysis for evaluation of implant osseointegration and screw loosening

    Miyashita M, Ogawa T, Naito H, Wang AS, Sasaki K

    2018/08

  36. OA治療のアドヒアランス －国内外の違いと問題点－

    小川 徹

    日本睡眠学会 第43回定期学術集会　2018/07

  37. Possibility of Pure Cellulose Nanofiber as a Denture Base Material

    Yamazaki Y, Ogawa T, Hong G, Hamada T, Sasaki K

    2018/07

  38. Resonance frequency analysis for estimation of osseointegration and screw loosening

    Miyashita M, Ogawa T, Naito H, Wang AS, Sasaki K

    2018/07

  39. The Influence of Cellulose Nanofibers on Mechanical Properties of Denture Base Resin

    Zou W, Hong G, Yamazaki Y, Ogawa T, Tanaka H, Hashiba H, Sasaki K

    2018/01

  40. 口内健康で長生き

    小川 徹

    七ヶ宿町 市民講座　2017/11

  41. マウスピースで快眠 －睡眠時無呼吸症の歯科的治療－

    小川 徹

    平成29年度公益社団法人日本補綴歯科学会東北・北海道支部学術大会　2017/10

  42. Estimation of implant osseointegration and abutment screw loosening by resonance frequency analysis

    Ogawa T, Miyashita M, Naito H, Shuhua W, Shibamotoa A, Shobara K, Takahashi H, Sasaki K

    2017/10

  43. アミロライドがオクタアルギニン/ リン酸カルシウムを用いた遺伝子導入に及ぼす影響

    バネガス サネンズ, フアン ラモン, 天雲太一, 鎌野優弥, 江草 宏, 小川 徹, 佐々木啓一

    日本補綴歯学会第126回学術大会　2017/06

  44. セルロースナノファイバーの歯科生体材料への応用に関する検討 −セルロースナノファイバーの基礎的物性の評価−

    山崎友起子, 小川徹, 洪光, 田中裕之, 橋場洋美, 夕田貞之, 樋口鎮央, 濱田泰三, 佐々木啓一

    第9回日本義歯ケア学会学術大会　2017/02

  45. Effect of mandibular advancement splint treatment on tongue and soft palate shape change in obstructive sleep apnea.

    Ogawa T, Long J, Sutherland K, Chan SL A, Sasaki K, Cistulli PA

    2016/12

  46. 閉塞性睡眠時無呼吸症に対する 口腔内装置による治療

    小川 徹

    伊賀歯科医師会 在宅介護・学術研修会　2016/11

  47. Mandibular advancement splint treatment effect on Tongue shape change in obstructive sleep apnea patients.

    Long JL, Ogawa T, Sutherland K, Chan SL A, Sasaki K, Cistulli AP

    2016/08

  48. 下顎前方移動時の舌形態：閉塞性睡眠時無呼吸症に対する口腔内装置の治療効果予測.

    小川 徹

    日本睡眠学会第41回定期学術集会. シンポジウム21　2016/07

  49. Evaluation of osseointegration and screw loosening by resonance frequency analysis

    Miyashita M, Ogawa T, Naito H, Shibamoto A, Sasaki K

    2016/03

  50. Influence of low-magnitude high-frequency loading and parathyroid hormone on peri-implant bone healing and osseointegration in OVX rats

    Aya Shibamoto, Toru Ogawa, Yoshiaki Kanda, Joke Duyck, Ignace Naert, Keiichi Sasaki

    2015/10/16

  51. 留学の活かし方・楽しみ方

    小川 徹

    第９回顎口腔機能セミナー　2015/08

  52. 研究に役立つ統計学の基本

    小川 徹

    第９回顎口腔機能セミナー　2015/08

  53. 閉塞型睡眠時無呼吸症候群治療の現状と今後の展開 －OA装着に伴う舌の形態変化に関する検討－

    小川 徹

    日本補綴歯科学会 第１２４回学術大会　2015/05

  54. Effect of low-magnitude and high-frequency loading on peri-implant bone healing and osseointegration in rats

    Ogawa T, Shibamoto A, Zhang X, Naert I, Sasaki K, Duyck J

    2014/11

  55. 東北大学病院における全身麻酔下歯科治療チームの設立

    水田 健太郎, 安田 真, 笹崎 弘己, 小川 徹, 冨士 岳志, 橋元 亘, 高橋 温, 山田 亜矢, 正木 英二, 五十嵐 薫

    みちのく歯学会雑誌　2013/12

  56. あなたのいびきは大丈夫？ー睡眠時無呼吸症への歯科的対応ー

    小川 徹

    元気！健康！フェア in とうほく　2008/04/01

  57. Relationship between periodontal tactile sensation and occlusal loading condition International-presentation

    Ogawa T, Suzuki T, Oishi N, Ito T, Inoue M, Kawata T, Sasaki K

    IADR 85st General session and exhibition, 2007　2007/03/21

  58. In vivo 3- dimensional load on implants supporting overdenture International-presentation

    N. Yoda, T. Kawata, H. Suenaga, R. Shigemitsu, T. Ogawa, T. Kuriyagawa, K. Sasaki

    IADR 85th General session and exhibition　2007/03/21

  59. 下顎臼歯の歯根膜触・圧覚と咬合力・咬合接触面積との関連の検討

    小川 徹, 鈴木 祐, 大石 直, 伊藤利実, 井上美香, 川田哲男, 佐々木啓一

    第11回The Japan Academy of Orofacial Pain　2007/01/14

  60. 下顎臼歯の歯根膜触・圧覚と咬合力・咬合接触面積との関連

    小川 徹, 大石 直, 鈴木 祐, 伊藤利実, 井上美香, 川田哲男, 佐々木啓一

    日本顎口腔機能学会第37回大会　2006/11/18

  61. 閉塞型睡眠時無呼吸症症例へのオーラルアプライアンス治療-歯科補綴学的見地からの検討-

    小川 徹

    平成18年度日本補綴歯科学会東北・北海道支部学術大会　2006/10/28

  62. 多数歯欠損のOSAS症例に対するオーラルアプライアンス治療の検討

    小川 徹, 伊藤利実, 鈴木 祐, 真柳 弦, 南 匠, 島内英俊, 川田哲男, 佐々木啓一

    第115回日本補綴歯科学会学術大会　2006/07/08

  63. 部分床義歯床下粘膜面に加わる圧力の生体内多点同時測定

    末永華子, 川田哲男, 久保 圭, 重光竜二, 依田信裕, 小川 徹, 佐々木啓一

    第115回日本補綴歯科学会学術大会　2006/07/08

  64. オーバーデンチャー支台インプラント荷重の三次元解析システムの開発とその生体内応用

    依田信裕, 川田哲男, 小川徹, 久保圭, 末永華子, 重光竜二, 厨川常元, 佐々木啓一

    第115回日本補綴歯科学会学術大会　2006/07/08

  65. 多数歯欠損を有するOSAS症例に対するオーラルアプライアンス治療の検討

    小川 徹, 伊藤利実, 鈴木 祐, 真柳 弦, 島内英俊, 岡部慎一, 佐々木啓一

    日本睡眠学会第31回定期学術集会　2006/06/29

  66. Measured Pressure Distribution under Denture Base of RPD in vivo International-presentation

    K. Kubo, T. Kawata, T. Ogawa, H. Suenaga, N. Yoda, R. Shigemitsu, K. Sasaki

    IADR 84th General session and exhibition　2006/06/28

  67. 部分床義歯補綴学教育におけるＰＢＬチュートリアル ―アンケート結果から振り返る―

    川田哲男, 横山政宣, 久保 圭, 小川 徹, 羽鳥弘毅, 佐々木具文, 井上美香, 塙 総司, 佐々木洋人, 野地美代子, 佐々木啓一

    第25回日本歯科医学教育学会総会および記念大会　2006/06/15

  68. 部分床義歯床下粘膜面に加わる圧力の生体内多点同時測定

    末永華子, 久保 圭, 川田哲男, 重光竜二, 依田信裕, 小川 徹, 佐々木啓一

    第３回東北大学バイオサイエンスシンポジウム　2006/05/29

  69. 部分床義歯粘膜面における生体内圧力多点同時測定

    久保 圭, 川田哲男, 南 文将, 重光竜二, 末永華子, 依田信裕, 小川 徹, 佐々木啓一

    第114回日本補綴歯科学会学術大会　2005/10/01

  70. 部分床義歯粘膜面に加わる圧力の生体内多点同時測定

    久保 圭, 川田哲男, 南 文将, 重光竜二, 末永華子, 依田信裕, 小川 徹, 佐々木啓一

    日本補綴歯科学会東北・北海道支部　2005/09/10

  71. Treatment for Obstructive Sleep Apnea Syndrome Using Oral Appliances Designed Considering Stomatognathic Functions International-presentation

    Ogawa T, Itoh T, Kawata T, Sasaki K

    The 4th Biennial Congress of AAP　2005/08/09

  72. Changes in periodontal conditions of direct abutment teeth five years after RPD placement International-presentation

    Chiba T, Kawata T, Koyama S, Gorai S, Toki N, Ogawa T, Yokoyama M, Hatori K, Inai T, Sasaki K

    The 4th Biennial Congress of AAP　2005/08/09

  73. Behavior of 3-dimensional loads exerted on a tooth during function International-presentation

    N. Yoda, T. Kawata, H. Suenaga, T. Ogawa, T. Kuriyagawa, K. Sasaki

    The 4th Biennial Congress of AAP　2005/08/09

  74. Tractive force exerted on teeth during chewing measured with 3-D transducer on vivo International-presentation

    Kawata T, Yoda N, Suenaga H, Ogawa T, Sasaki K, Kuriyagawa T

    The 11th Meeting of the ICP　2005/05/25

  75. Changes in the Periodontal Conditions of Abutment and Non-Abutment Teeth Five Years after RPD Placement International-presentation

    Chiba T, Kawata T, Koyama S, Gorai S, Toki N, Ogawa T, Inai T, Kimura K, Watanabe M, Sasaki K

    The 11th Meeting of the ICP　2005/05/25

  76. Effect of low-magnitude and high-frequency loading on bone defect healing.

    Kanda Y, Ogawa T, Vandamme K, ShibamotoA, Zhang X, Naert I, Sasaki K, Duyck J

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Industrial Property Rights 6

  1. 親水化表面処理剤

    坂田英武, 平田広一郎, 相澤将之, 洪 光, 佐々木 啓一, 小川 徹

    特許第7168936号

    Property Type: Patent

  2. 健康状態評価装置

    土井 千章, 豊岡 継泰, 檜山 聡, 佐々木 啓一, 川島 隆太, 野内 類, 小川 徹, 依田 信裕, 白石 成, 日原 大貴, 阿部 真澄

    Property Type: Patent

  3. 認知機能状態推定モデル生成装置、認知機能状態推定モデル及び認知機能状態推定装置

    土井 千章, 豊岡 継泰, 檜山 聡, 佐々木 啓一, 川島 隆太, 野内 類, 小川 徹, 依田 信裕, 白石 成, 日原 大貴, 阿部 真澄

    Property Type: Patent

  4. トレーニング支援装置

    土井 千章, 豊岡 継泰, 檜山 聡, 佐々木 啓一, 川島 隆太, 野内 類, 小川 徹, 依田 信裕, 白石 成, 日原 大貴, 阿部 真澄

    Property Type: Patent

  5. セルロース系成形体の製造方法、当該製造方法で得られるセルロース系成形体、及び歯科用ミルブランク

    坂田 英武, 平田 広一郎, 相澤 將之, 橋場 洋美, 佐々木 啓一, 洪 光, 小川 徹, 濱田 泰三

    Property Type: Patent

  6. 親水化表面処理剤

    坂田英武, 平田広一郎, 相澤将之, 洪 光, 佐々木 啓一, 小川 徹

    Property Type: Patent

Show all Show first 5

Research Projects 44

  1. Development of a novel intraoral imaging system adaptable to online treatment using SS-OCT.

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2025/04/01 - 2028/03/31

  2. OSA病態フェノタイプの識別AIを応用した個別化治療戦略の創成

    内藤 英樹, 日原大貴, 小川浩正, 重光竜二, 泉田明男, 加地 仁

    Offer Organization: 科学研究費助成事業（学術研究助成基金助成金）

    Category: 基盤研究(C)（一般）

    2025/04 - 2028/03

  3. 共振周波数解析にAIを応用した歯冠補綴装置の異常検知デバイス

    小川 徹, 内藤英樹, 日原大貴, 重光竜二

    Offer Organization: 公益財団法人 テルモ生命科学振興財団

    System: 開発助成金

    Category: 医療機器開発

    2024/01 - 2028/03

  4. Aprication of cellulose nanofiber and bioplastic composites for new dental material

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2024/04/01 - 2027/03/31

  5. 感染チタン表面の殺菌・再感染予防・組織再生を有するインプラント周囲炎治療法の開発

    小川 徹, 佐々木 啓一, 日原 大貴, 天雲 太一, 互野 亮, 庄原 健太, 山口 洋史

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 国際共同研究加速基金(国際共同研究強化(B))

    Category: 国際共同研究加速基金(国際共同研究強化(B))

    Institution: 東北大学

    2022/10 - 2027/03

    More details Close

    本研究は、リン酸カルシウムナノ粒子を基材とした遺伝子導入剤を、DefensinやMagaininなど様々な抗菌ペプチドでコーティングすることで口腔内細菌に効果的な抗菌性を示し、かつ歯肉結合組織由来細胞に対して高い遺伝子導入効率を示す組み合わせを検討する。次に遺伝子導入剤内部に抗炎症性を示すsiRNAやBMP-2などの硬組織誘導性細胞賦活因子を発現させるplasmid-DNAなどを複数種搭載させ、骨造成能をin vivoで検証する。これらの結果を基に、インプラント周囲炎に適用し、オステオインテグレーション獲得性を評価する。さらに組織の早期治癒のために高周波振動刺激を行い骨形成促進効果について検討するものである。 R4年度は、可視光・UVC照射装置を購入し、感染チタン表面において銀イオン存在下で青色LEDを照射することで殺菌効果に加え、光触媒活性によるチタン表面性状の回復ができるのではないかという仮説のもと、黄色ブドウ球菌を用いてその検証を行った。 インプラント表面を模倣したチタンディスク（サンドブラスト処理、リン酸エッチング処理後、黄色ブドウ球菌を播種、培養しバイオフィルムを作成）上に、濃度の異なる硝酸銀溶液を加え、青色LEDを1分間照射し、殺菌効果をコロニー形成単位の測定により評価した。また、各処理を行った後のチタン表面の接触角を測定して、表面性状の親水性を評価した。さらに各処理後のチタンディスク上に骨芽細胞様細胞（MC3T3E1）を播種し、培養2日後にMTT試験を行い、細胞親和性の評価を行った。 その結果、銀イオンと可視光領域の青色LED照射の併用法は、浮遊状ならびにバイオフィルムを形成した黄色ブドウ球菌の殺菌作用だけでなく、感染チタン表面の親水性を回復する効果が認められた。

  6. Development of a total therapy for the peri-implantitis made of titanium alloy

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2023/04/01 - 2026/03/31

  7. Development of the total therapy of tissue regeneration for peri-implantitis

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2023/04 - 2026/03

  8. Neurophysiological analysis of oral function improvement using diffusion tensor imaging

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2023/04 - 2026/03

  9. 拡散テンソル画像を応用した内側・外側翼突筋等の咀嚼筋筋線維動態の解析

    庄原 健太, 小川 徹, 依田 信裕, 佐々木 啓一

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2023/04 - 2026/03

  10. Basic study of pure cellulose nanofibers as a bioinert material for clinical application

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2023/04 - 2026/03

  11. Effect of prosthodontic treatment on conscious swallowing function

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2022/04 - 2025/03

  12. ⾼齢者の飲み込みやすさに影響を及ぼす味と栄養素に関する検討

    小川 徹, 東北大学農学研究科, 教授 白川仁, 歯学研究科, 教授 金髙弘恭, 歯学研究科大学院生, 小出理絵

    Category: 令和5年度 食学拠点研究スタートアップ支援制度

    2023/12 - 2024/04

  13. 高周波振動刺激の骨形成促進効果を利用したインプラント治療支援機器の開発

    宮下 牧子, 佐々木 啓一, 小川 徹, 天雲 太一, 日原 大貴

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(C)

    Category: 基盤研究(C)

    Institution: 東北大学

    2021/04/01 - 2024/03/31

    More details Close

    歯科インプラントは，欠損補綴における標準的な治療オプションとして歯科臨床において広く普及した．しかしながら，日常臨床においては，欠損部の骨量・骨質が不十分な場合や，骨造成を行った場合，さらには骨粗鬆症や糖尿病など骨治癒不全ケースでは，インプラント埋入後の周囲骨形成が充分になされず，オッセオインテグレーションが獲得されない，もしくは治癒期間が大幅に延長してしまう等の症例が依然として多く存在する．これら理由から治療を断念する患者は，歯科インプラントを希望する患者の実に２割以上に及ぶとされる．このような臨床的課題に対して，薬物による副作用や外科的侵襲を伴わず，安全で，簡便に骨形成とオッセオインテグレーション獲得促進をサポートする支援デバイスの開発は非常に意義深い． 本研究は，歯科インプラント治療支援を目的としたインプラント周囲骨形成・オッセオインテグレーション促進効果をもつ低強度・高周波振動刺激デバイスの開発を目指すものである．アカデミア主導型医療機器開発であり，新規口腔デバイス開発（基礎データ収集，技術の知財化，機器開発），トランスレーショナルリサーチ，非臨床POC(Proof of Concept)の取得という２つのステップから構成される． 昨年度は，ヒト口腔内への応用を想定した小型の刺激デバイスの試作機の設計，口腔内に維持・固定する方法および振動刺激の周波数・強度等の条件の検討を行った．

  14. マイクロ波ドライプロセスによるTiN表面改質のインプラントアバットメントへの応用

    伊東 明代, 小川 徹, 福島 潤, 洪 光, 滝沢 博胤, 佐々木 啓一

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(C)

    Category: 基盤研究(C)

    Institution: 東北大学

    2021/04/01 - 2024/03/31

    More details Close

    TiNコーティングは, 硬度, 耐摩耗性, 耐食性等に優れ, 審美的な金色を呈すること, さらに抗菌性や生体親和性も期待されるため, 歯科インプラントアバットメント表面の機能向上にも適していると考えられる. しかし, 従来の成膜法(PVD法, CVD法等)では, アバットメントのような複雑な立体構造体への応用は難しく, 成膜プロセス上の煩雑さ, 安全面やコスト面においても様々な問題が残されている. マイクロ波ドライプロセスTiNコーティング法は,圧力や雰囲気置換を行わない大気中においてTiN形成が可能という独自性を持ち, 安価で簡便なプロセスであり, アバットメントへの応用に適している. 本研究は, 硬度, 耐摩耗性, 耐食性, 審美性, 細胞動態および軟組織封鎖性という観点から, マイクロ波ドライプロセスTiNコーティング法のアバットメント表面における最適成膜条件の探索を行い, トランスレーショナルリサーチの展開へ向けての基盤を形成する. 今年度は, 市販のアバットメントへの応用を想定した試料の作製・材料学的評価を進めた. Ti6Al4円盤(直径5mm, 厚さ1mm)にマイクロ波ドライプロセスによるTiNコーティングを施した試料を作製した. 反応時間は10分とし, 800℃, 850℃, 900℃, 950℃, 1000℃の反応温度でコーティングを施した. SEM像では全ての反応温度において波模様の微細構造を認めた. XRD分析の結果からは, 反応温度が高いほど窒化が進行しており, 950℃, 1000℃でTiNを認めた. この結果, 市販のアバットメントへの成膜条件として, 上記の反応温度が妥当であることが確認された.

  15. 飲み込みやすさに影響を及ぼす味と栄養素に関する検討

    小川 徹, 東北大学農学研究科, 教授 白川仁, 歯学研究科, 教授 金髙弘恭, 歯学研究科大学院生, 小出理絵

    Category: 令和4年度 食学拠点研究スタートアップ支援制度

    2022/12 - 2023/04

  16. Study for biocompatibility of 100% cellulose nanofiber bulk

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)

    Category: Grant-in-Aid for Challenging Research (Exploratory)

    Institution: Tohoku University

    2020/07/30 - 2023/03/31

  17. Research for the musculoskeletal simulation based on biological data

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2020/04/01 - 2023/03/31

  18. 拡散テンソル画像を応用した咬筋内部筋線維動態の解析手法の確立

    庄原 健太, 小川 徹, 橋本 照男, 依田 信裕, 佐々木 啓一

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(C)

    Category: 基盤研究(C)

    Institution: 東北大学

    2020/04/01 - 2023/03/31

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    拡散テンソル画像（DTI：Diffusion tensor imaging）は，組織内の水分子の拡散方向を探知することで生体内の線維状走行を捉える手法であり，神経線維のみならず現在では四肢の骨格筋線維の走行解析に応用されている．本研究は，DTI解析を応用し咬筋内部の筋線維走行の3次元的に捉える手法を確立し，さらに種々の下顎運動時におけるその形態変化の詳細を捉えることを目的とする．本研究は，咀嚼筋でみられる局所的な筋痛の発現機序の解明，さらに患者個々の筋痛発症の原因の診断，治療へと臨床展開するための基盤となる基礎研究である． 上述の通り，これまでDTIを応用した解析は主に脳神経分野で活発に行われてきたため，これらの解析に用いられるソフトウェアもほとんどが脳神経への応用を前提としたものであった．また，骨格筋への応用例は増加してきているが，骨格筋よりも複雑な形態を有す多羽状筋である咬筋を扱った研究は稀有であり，撮像方法も定まってはいない．そこで今年度は，咬筋に適した撮像条件設定を選定し，データ解析手法の確立を行った．DTIを応用して生体内の線維構造解析を行う手法をファイバートラクトグラフィーと呼ぶが，この結果に大きく影響を及ぼす撮像条件設定として，b値，撮像加算回数，傾斜地場軸数があげられる．これらの設定が咬筋筋線維描出にどのような影響を及ぼすかについて，撮像条件に複数のパターンを設け，5名の健常被験者の撮像を行い解析した．解析に関しては，咬筋の複雑な線維構造に対応できるよう新たな形態解析ソフトウェアを構築した． この結果，過去の解剖学的知見と照らし合わせてもDTIによって得られる線維の線維長および線維方向はおおむね妥当であることが確認された．一方で，咬筋のDTIファイバートラクトグラフィーにおいて，撮像条件の設定が線維長および線維方向の結果に影響を与えることが明らかとなった．

  19. 空中超音波および体内エコーを利用した人体の運動状態の非侵襲計測手法の確立

    科学技術創成研究院, 田原麻梨江, 平田慎之介

    Category: 令和4年度生体医歯工学共同研究拠点共同研究

    2022/04 - 2023/03

  20. Development of next generation drug delivery system using gene transfection vector

    Kanda Yoshiaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2019/04/01 - 2022/03/31

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    Protamine-coated multi-shell calcium phosphate (CaP) was developed as a non-viral vector for tissue regeneration therapy in this study. The antibacterial effects of CaP nanoparticles against Streptococcus mutans and Aggregatibacter actinomycetemcomitans increased with an increase in the protamine dose. In the combination treatment with BMP-2 and IGF-1, the concentration ratio of BMP-2 and IGF-1 is an important factor affecting bone formation activity. During gene transfection treatment, BMP-2 and IGF-1 were released simultaneously after gene transfer; the loaded dose of the plasmid DNA encoding IGF-1 did not impact the BMP-2 or IGF-1 yield or new bone formation ratio in vitro and in vivo. In conclusion, two growth factor-releasing systems were developed using an antibacterial gene transfer vector, and the relationship between the loaded plasmid DNA dose and resultant growth factor yield was determined in vitro and in vivo.

  21. Modal analysis for estimation of osseointegration and screw loosening

    Miyashita Makiko

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2018/04/01 - 2021/03/31

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    The aim of this study was to evaluate the development of implant osseointegration and screw loosening using resonance frequency analysis in the rabbit tibia, and to correlate the results with histomorphometric measurements. The accuracy of resonance frequency analysis was examined using the mandible model and the finite element analysis model. Animal experiments suggest that resonance frequency analysis can be detect the progress of osseointegration and loosening of the abutment screw.

  22. Effect of hydrophobic treatments on basic physical properties of cellulose nanofibers for a dental material

    Yokoyama Masayoshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2018/04/01 - 2021/03/31

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    The aim was to evaluate the basic mechanical properties of a pure cellulose nanofiber (CNF) specimen compared with a commercial denture base material (PMMA acrylic resin). Pure CNF specimens fabricated under various conditions were examined. The flexural strength (FS) and flexural modulus (FM) values of the specimens were measured by a three-point bending test. The morphologies of the fractured surfaces were examined using SEM. The hydrophobic treatment with an anionic surface sizing agent did not improve their water absorption. The hydrophobic specimens with substitution by methanol favorably affected the mechanical properties of the CNFs. The pure CNF specimen fabricated under particular conditions had higher FS and FM values than the control, which suggests that CNFs have potential as a "petroleum-free" alternative to acrylic resin denture base materials. The pure CNF is potentially useful as a denture base material, which is assumed to be applicable to CAD/CAM.

  23. ナノジルコニアにおける生体親和性のメカノバイオロジカルな制御機構の解明

    松井 裕之, 佐々木 啓一, 洪 光, 小川 徹

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(C)

    Category: 基盤研究(C)

    Institution: 東北大学

    2019/04/01 - 2020/03/31

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    本研究期間においては，歯科用インプラント材料として用いられるチタンおよびジルコニア表面において，骨芽細胞が「良好な」形態形成を示すことに直接関与する分子の特定を目的としている．物質表面に対する細胞接着には，細胞外基質とこれに対する受容体である細胞膜タンパクの結合が必要である．これまでの研究から，細胞接着に主要因子とされるインテグリンはハイドロキシアパタイト上への接着には重要であったがインプラント材料として頻用されるチタンにおいては必須ではないことが明らかにされている．さらに我々の知見では，ジルコニアおよびチタン上での細胞接着はインテグリンのみでは不十分であり，特にヘパラン硫酸プロテオグリカン（Heparan sulfate proteoglycan : HSPG）の関与が示唆された．HSPGには膜貫通型のSyndecan, GPIアンカー型のGlypican，分泌型のSerglycineやPerlecanが存在するため，分子種の絞り込みが必要である．一方，我々のこれまでの研究成果では，ジルコニア表面に対する骨芽細胞の接着はEDTAおよびヘパリンにより阻害されることから，Laminin結合タンパクの関与が疑われていた．この条件に適合するHPSGはSyndecanファミリーであったため，詳しい分子種の特定を目的としてRNAiによるスクリーニングを行っている．現在，有望なSyndecanファミリー遺伝子についてOff-target効果の排除などを含めて裏付けを進めているところである．

  24. PETバリデーティッドFEAに基づく顎骨リモデリングシミュレーションの構築

    水戸 武彦, 重光 竜二, 末永 華子, 依田 信裕, 小川 徹, 佐々木 啓一

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(C)

    Category: 基盤研究(C)

    Institution: 東北大学

    2018/04/01 - 2020/03/31

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    当該研究は, 歯科インプラントに生じる臨床的偶発症の予防, さらには歯科インプラントの埋入に係るメカノバイオロジカルな反応を考慮した顎骨リモデリングシミュレーションの最適化に寄与することを主眼としたものである. 従来の解剖学的な観点を考慮した手法に加えて本シミュレーションを埋入システムに包含することで, より安全で効率的な歯科インプラント治療を実現することが期待される. 初年度は, 有限要素解析モデル（以下, FEモデル）の作成を行った. 共同研究者の小川らが確立した実験モデルを踏襲して，Wistar系ラットの脛骨部について純チタンのカスタムメイドインプラントを埋入したモデルを用いて解析を行った. 前述の手法から複数のFEモデルを作成して, 骨リモデリングシミュレーションの解析に堪えうるFEモデルの接点数や要素数について検討を行った. 次年度は, 初年度に得られた結果を元に各種解析をコンター図及び応力ヒストグラムよりインプラント周囲骨における3次元的な応力状態について定性及び定量分析による検討を行った．特に, ラット脛骨の皮質骨および海綿骨の材料特性ついて, 部位特異的な骨梁構造及び材料非線形性を考慮した設定を行った. これより骨内領域を従来手法に比べてより実現象の再現性に富んだモデル構築に成功した. 加えて, 本モデルは経時的な骨代謝の観察と対照することでインプラントの骨梁形態変化の評価を行う基盤となるFEモデルとなるよう設定を検討した.

  25. The Application of TiN coating by microwave irradiation on oral implant abutments

    Ito Aya

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2017/04/01 - 2020/03/31

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    This study aimed to assece the effect of TiN coatind by microwave irradiation (TiN-Mw) on surface properties and fibroblast cellular responses, and to examine its optimal condition applied for oral implant abutments.The findings suggest that TiN-Mw can be a promising surface modification of titanium alloy for oral implant abutments, improving mechanical properties and soft tissue affinity.

  26. Development of remodeling FEA based on the morphological assessment of temporal CT data

    Ryuji Shigemitsu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2017/04/01 - 2020/03/31

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    This study was aimed to elucidate the biomechanical effects of bone remodeling over a period of 12 years by means of morphological assessment and finite element analysis (FEA) studies from CT data. The subject with an implant-supported overdenture, was chosen to clarify the effects. Two kinds of FE models were constructed from CT data taken at two time points: pre-implantation (Model A) and 12 years post-implantation (Model B). The results show a homogenization of the stress and strain energy density between the implant regions from Model A to Model B. The results of the morphological assessments demonstrated that the bone mass and quality had significantly changed over 12 years. Area-specific bone resorption was also observed at the bone surrounding each implant. The combined findings indicate that the homogenization of mechanical factors was due to chronological changes in bone morphology, suggesting adaptation to mechanical loads by peri-implant bone remodeling.

  27. Study of mechano-biology in peri-implant bone healing under various loadings

    Kenta Takahashi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2017/04/01 - 2020/03/31

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    In this study, we focused on the mechano-biology of peri-implant bone healing with various loadings. As test conditions, low frequency loading, low magnitude-high frequency (LMHF) loading and low intensity pulsed ultra-sound (LIPUS) are used. The combination of LIPUS and LMHF loading may promote osteogenic activity around the implant. However, further study of the stimulation conditions of LIPUS and LMHF loading is necessary to better understand the osteogenic effects and the relationship between the two stimuli. LMHF loading positively influenced peri-implant bone healing in the early healing period in beagle dog mandible.

  28. Synergetic effect of whole-body vibration and low intensity pulsed ultra-sound on peri-implant bone healing and osseointegration in rat tibiae.

    Kanda Yoshiaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

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    The aims of this study were (i) to compare the osteogenic impact of low-magnitude high-frequency (LMHF) loading and low intensity pulsed ultra-sound (LIPUS) on peri-implant bone healing and implant osseointegration in rat tibiae, and (ii) to examine their combined effect on these processes. Fifteen-week-old male Wister rats (n=28) received a Titanium implant in the proximal metaphysis of both tibiae. They were divided into 4 groups: 1) both whole body vibration (WBV) and LIPUS, 2) WBV, 3) LIPUS and 4) unloaded control (WBV: 50Hz at 0.5g, 15min/day, 5days weekly). The rats were sacrificed 1 or 4 weeks after implant installation. The results of this study reveal that although each LMHF loading and LIPUS do not show an osteogenetic effect on peri-implant bone, their combined application acts positively on peri-implant bone healing. These results suggest therapeutic potential to suport the peri-implant healing using combined application of LMHF loading and LIPUS in oral implant treatment.

  29. A study on optimized biomechanical implant prosthetic design based on bone remodeling algorithm using in vivo measured load

    Kawata Tetsuo

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2015/04/01 - 2018/03/31

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    This study combines clinical investigation with finite element (FE) analysis to explore the effects of buccal bone thickness (BBT) on the morphological changes of buccal bone. One patient who had undergone an implant treatment in the anterior maxilla and experienced the buccal bone resorption on the implant was studied. Morphological changes of the bone were measured through a series of CT scans. A 3D heterogeneous nonlinear FE model was constructed based on the CT images, and the in-vivo BBT changes are correlated to the mechanical stimuli. The anterior incisory bone region of this model was then varied systematically to simulate different BBTs. Significant changes in BBTs were observed clinically. The pattern of bone resorption fell into a strong correlation with the distribution of mechanical stimuli onsite. This study revealed that the initial BBT can significantly affect mechanical responses, which consequentially determines the bone remodeling process.

  30. Application of effect of low-magnitude and high-frequency loading and bone anabolic agents on peri-implant bone in a osteoporosis model

    YOKOYAMA Masayoshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2015/04/01 - 2018/03/31

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    This study aimed to examine the effect of low-magnitude, high-frequency (LMHF) loading, and bone anabolic agents such as parathyroid hormone (PTH) on peri-implant bone healing in an osteoporosis model, and to assess their combined effects on these processes. The findings suggest that LMHF loading and PTH can act locally and additively on the bone healing process, improving the condition of implant osseointegration.

  31. Study on relationship between facial and masticatory muscles activities and facial morphology in patients with tooth contacting habit

    Hanawa Soshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2015/04/01 - 2018/03/31

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    During pulling the corner of mouth, the RMS values of buccinator and levator anguli oris muscles were highest at mandibular rest position. During contacting upper and lower teeth, the RMS values of these facial muscles were proportional to the clenching level. On the other hand, these RMS values of these facial muscles were highest at 50% of maximum voluntary clenching of the teeth. The RMS values of these facial muscles were observed to be lowest at the mandibular rest position and increased as the level of the clenching increased. It was suggested that the activities of the buccinator and levator anguli oris muscles were decreased due to the influence of contact between the upper and lower teeth.

  32. Development of optimizing simulation for treatment palanning with dental implant.

    SHIGEMITSU RYUJI

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2014/04/01 - 2017/03/31

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    This time we would like to focus on how the superstructure design of implant-supported fixed prosthesis and the number of implant affects mechanical behavior. The patient is 67-year-old woman, and three implants were installed between second premolar to second molar region in the left side of mandible. 3 Types of superstructure design were modeld with biological loading data.In summary,1) Decrease of the number of implants supporting FPDs doesn’t always cause an increase of stress and displacement.2) Cantilever bridge design causes an increase of stress and displacement.3) The stress and displacement were increased remarkably during function. Finally in conclusion, from this study, the design of cantilever bridge may cause an increase of stress in peri-implant bone and displacement of superstructure in implant-supported FPDs.

  33. Evaluation of osseointegration and screw loosening by modal analysis

    Ogawa Toru, MIYASHITA MAKIKO

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2014/04/01 - 2017/03/31

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    The aim was to examine the progress of implant osseointegration and screw loosening by means of a resonance frequency analysis (RFA) in the rabbit tibia. One mature New Zealand White rabbit was used. Six titanium implants were installed in the tibiae bilaterally. A small 3D-accelerometer was mounted and screwed onto the implant, and flexural oscillation was directly applied to the implant to obtain the RFA values (RFx and RFy). ISQ value with Osstell was also measured immediately after implantation. After 8 weeks, RF values of different screw loosening were recorded. ISQs tend to decrease until 7 to 10 days after installation and then gradually increased. RFx and RFy had not reached the stage in predicting the progress of osseointegration. According to degree of screw loosening, the RF values decreased. The results suggest that although this RFA method have not been enough to detect the progress of osseointegration, it can be used for the detection of the screw loosening.

  34. Mechanobiology in peri-implant bone evaluated by the bone metabolism and stress distribution

    YOKOYAMA Masayoshi, OGAWA Toru, SASAKI Keiichi, HUNAKI Yoshihito, IKEDA Kiyohiro, YAMAKAWA Yuki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2012/04/01 - 2015/03/31

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    This study aimed to examine the influence of mechanical loading on the dynamic changes of bone metabolism around dental implants using a super-high resolution semiconductor sodium 18F-fluoride (Na18F)-PET and FEM analysis. CT scanning was also performed in order to determine the anatomical orientation in the PET images, the images were superposed onto CT images. The results suggests the loading effects in early stage on peri-implant bone formation. Furthermore we evaluated the effect of low-magnitude and high-frequency (LMHF) loading, applied by means of whole-body vibration (WBV), on peri-implant bone healing and implant osseointegration in ovariectomized rats treated with alendronate (Ale) and parathyroid hormone (PTH) [1-34]. The results showed that combined treatment of WBV with PTH enhances peri-implant bone healing and implant osseointegration most.

  35. The effect of the configuration of implants supporting fixed partial denture on the load distribution based on in vivo measurement

    KAWATA Tetsuo, YODA Nobuhiro, SASAKI Keiichi, OGAWA Toru

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2012/04/01 - 2015/03/31

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    The aims of this study are to develop a device for in vivo measurement of three-dimensional (3D) loads in the implants, and to further investigate the implant configuration effects on the load distribution under a fixed partial denture (FPD). A 67-year-old female subject with three implants in mandibular molar area (35, 36, 37). The 3D load-measuring device consisted of piezoelectric transducers and an superstructure. The loads on the implants were recorded during the maximum voluntary clenching (MVC) and chewing a piece of chewing gum (GUM). With the 3I and the Br, the loads exerted on each implant were evenly distributed in both test scenarios. The maximum loads of 335.5 N and 277.6 N were detected on the 36-implant in DCBr and MCBr, respectively, and the tensile load was observed on the 35-implant of DCBr during the GUM. The 36-implant exhibited the largest load in DCBr due to the cantilever effect, with significant margins compared to MCBr and 3I during the GUM (p<0.01).

  36. A study on the interrelations between patient QOL and facial morphological characteristics baced on three-dimensional measurement

    HANAWA Soshi, SASAKI Keiichi, KOYAMA Shigeto, OGAWA Toru

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2012/04/01 - 2015/03/31

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    The purpose of this study was to clalify the effect of maxillary obturator prostheses on facial morphology in unilateral maxillary defect patients. The facial data of 8 patients were acquired with a 3-dimensional digitizer, both with and without prostheses. Displacement at 18 measurement points, including 7 bilateral pairs, was compared between the 2 sides with and without the prostheses. Asymmetry indices of these 7 pairs were also calculated. Displacements of the lateral and inferior points at the ala of the nose were significantly greater on the defect side than on the normal side. The distances between the ideal and defect side points at the superior ala, the upper lip, and the angle of the mouth decreased significantly with the prosthesis. The angle of the upper lip line to the midsagittal plane increased significantly with the prosthesis. The prostheses affect the region of the nasal ala, the upper lip, and the angles of the mouth.

  37. A study of the effect of implant supported partial overdenture by measuring loads on the abutment teeth and residual ridge

    KEI KUBO, SASAKI Keiichi, OGAWA Toru, YODA Nobuhiro, SUENAGA Hanako

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2011 - 2013

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    This study aimed to reveal effects of the number and position of implants which support a partial overdenture (I-POd) on mechanical loads exerted onto the abutment tooth of the denture and on the residual ridge beneath the denture.Two implants were placed at the second premolar (imp1) and the second molar (imp2) position in edentulous area of model. Load onto the abutment tooth was measured by a piezo-electric 3D-force transducer. Load exerted on residual ridge beneath the denture was measured by a tactile sheet-sensor.Measurements were performed in four test conditions as follows: no implants supporting the denture, imp1 supporting the denture, imp2 supporting the denture and imp1 and imp2 supporting the denture.Loads onto the abutment tooth and residual ridge beneath the denture base were significantly associated with the implant number and position of I-POd. Application of implants beneath the denture base contributes to reduce the loads onto the abutment tooth and residual ridge.

  38. Application of effect of low-magnitude and high-frequency loading on peri-implant bone to the implant

    OGAWA Toru, SASAKI Keiichi, IKEDA Kiyohiro, YAMAKAWA Yuki, SHIGEMITSU Ryuji

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2011 - 2013

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    This study aimed to examine the influence of various loading on dynamic changes of bone-metabolism around the implant using a super-high resolution [18F]NaF-PET in rat tibiae. Adult male Wistar rats installed experimental implant on the tibia were used in this study. Increase of bone-metabolism was observed until 7 days after implantation surgery and then gradually decreased. Differences in bone-metabolism between immediate loading and no-loading group were found. This suggests loading affects bone-metabolism around the implant. Also

  39. Biomechanical investigation of occlusio n on Implants-supporting Fixed Prostheses

    KAWATA Tetsuo, SASAKI Keiichi, OGAWA Toru, YODA Nobuhiro, SHIGEMITSU Ryuji, SUENAGA Hanako

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2009 - 2011

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    The 3-D load-measuring device, comprised of a piezo-electric force transducer and the experimental superstructure, was developed. The devices were tightened with screws into implant-fixtures in the subjects. The 3-D loads during the maximum voluntary cenching (MVC)and biting a piece of paraffin wax (WAX)were registered. The magnitude and direction of the recorded loads were analyzed in the spatial coordinates based on her Frankfort and sagittal planes. The device enabled us to estimate the 3-D loads on t he implants. Load exerted on the implant supporting fixed superstructure during chewing function was larger than that during clenching. The amount of change in the load direction during chewing was larger than that during chewing. It was suggested that the species of teeth or occulusal contact was affect the load direction

  40. Development of new oral cleaning system through the Powder Flow Polishing Metho

    DOI Naohiro, SASAKI Keiichi, OGAWA Toru, HANAWA Sosi, KURIYAGAWA Tunemoto

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2008 - 2010

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    his study aimed to investigate the new oral cleaning system applied the Powder flow Polishing (PFP)method. The experiment of cleaning up artificial plaque showed the validity of the oral cleaning system through the PFP method. Consequently, the possibility of making a new oral care easily and effectively using the PFP method was indicated.

  41. In vivo 3-D force real-time measurement on implant

    TAKAHIRO Chiba, KEIICHI Sasaki, TSUNEMOTO Kuriyagawa, TETSUO Kawata, TORU Ogawa, KEI Kubo

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2006 - 2008

  42. Three-dimensional bone formation by octacalcium phosphate combined with collagen

    KAWATA Tetsuo, SASAKI Keiichi, SUZUKI Osamu, KAMAKURA Shinji, KOYAMA Shigeto, KOHKI Hatori, OGAWA Toru, KUBO Kei

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2006 - 2008

  43. OSAS用口腔内装置に関する顎口腔機能および睡眠・呼吸機能からの検討

    小川 徹

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 若手研究(B)

    Category: 若手研究(B)

    Institution: 東北大学

    2006 - 2008

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    本研究課題は,OSASに対する口腔内装置(OA)を用いた治療法をより効果的にかつ確実なものとするため,下顎位およびオトガイ舌筋(GG筋)・咀嚼筋筋電図等の顎口腔機能と終夜ポリグラフ(PSG)検査による睡眠・呼吸機能を検索し,顎口腔機能および睡眠・呼吸機能という2つの観点から,OAに付与すべき下顎位の指標を確立しようとするものである. 被験者は健常成人男性4名で、実験用OAはGG筋筋電図記録用電極の設置および下顎を任意の位置へ固定するため、被験者毎に上下顎歯列を被覆するOAを製作した.GG筋記録用電極は自作の銀ボール電極(直径2mm)を用い,舌側床縁を舌運動を妨げない範囲で可能な限り延長した下顎OAの犬歯〜小臼歯部付近の床縁に設置した(電極間距離7mm)。呼吸状態は、ディスポーザブル・エアフローセンサー(株式会社ミユキ技研製)を用い記録した. (1)GG筋筋活動と呼吸動作:GG筋筋活動量は座位・仰臥位ともに呼気時に比べ呼気時において大きくなる傾向が認められたものの有意な差は認められなかった. (2)下顎位を前方に変化させた際:50%下顎前方位でのGG筋筋活動量は(下顎最大前方位における筋活動に対する割合)、座位で55.2%、仰臥位で65.2%と仰臥位で高い値を示した. (3)咬合高径を変化させた際:咬合高径を高くするにつれGG筋筋活動は上昇し、特に開口量12mmは座位で50.5%、仰臥位で71.7%と両体位ともに著しい筋活動量の上昇を認めた. 以上の結果から、GG筋活動は体位および下顎位に関連し、下顎位の前方への移動および咬合高径の挙上に伴い活動が大きくなることが示唆された。また座位に比べ仰臥位においてGG筋活動は下顎位の影響を受けやすいことが推察された。

  44. 自家移植歯の咬合機能に関する生理学的研究

    小川 徹

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 若手研究(B)

    Category: 若手研究(B)

    Institution: 東北大学

    2004 - 2005

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    本研究課題は,自家歯牙移植歯の咬合機能を生理学的な観点から明らかにすることを目的とし行った.移植歯の咬合機能の評価は一般的な歯周・咬合検査項目に加え,ダイナミック動揺度(ペリオテスト),咬合力負担能力(プレスケールおよび個歯咬合力),歯根膜感覚試験(フォンフライ毛)を指標とし行った.個歯咬合力の測定は小型圧トランスデューサ(PS-70KAM260:KYOWA)を用い対合歯の影響をなくすため,対合歯列はスプリントを装着した.歯根膜感覚試験はTouch-Test^<TM>(North Coast)を用い,精神物理学的手法にて上昇・下降系列を3サイクル行い,その感覚閾値の平均値を求めた.コントロールとして正常有歯顎者6名の下顎臼歯に対し種々の検査を行い,左右の同名歯間での差は認められなかった. 被験者は自家歯牙移植歯を有する成人4名で,移植歯は第三大臼歯を第1大臼歯部に移植したもので,移植後6ヶ月以上,歯冠補綴終了後3ヶ月以上経過したものを対象とした.被験歯としては,自家移植歯,対照歯A群(移植歯の同顎反対側同一部位の歯)および対照歯B群(移植に用いた歯の同顎反対側の歯)を設定した. (1)歯周検査,ダイナミック動揺度,プレスケール(被験歯の歯列上咬合力・咬合接触面積)は各群間に差は認められなかった. (2)歯根膜感覚試験では,移植歯群は5.4±0.4g,対照歯群はそれぞれ5.9±3.1g,6.1±2.6gで移植歯にて感覚閾値が小さい傾向がみられた. (3)個歯咬合力については,各被験者においても移植歯群は対照歯A群およびB群に比べ小さい値となった. 結果(1)より,移植歯が歯列内で正常に咬合力発揮や咀嚼などの機能に寄与していることが確認された.また(2)より移植歯は対照歯と比較し感覚閾値が小さいことが推察され,(3)より移植歯の咬合負担の能力に関しては移植した歯に近い制御がなされていることが示唆された.

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