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Teiji Tominaga

Section

Board Member

Job title

President

Degree

医学博士（東北大学）

researchmap

https://researchmap.jp/read0163726

J-GLOBAL ID

200901070283795000

e-Rad No.

00217548

Research History 2

1993/04 - 1993/05

バロー神経学研究所脳神経外科
1987/02 - 1988/06

フィラデルフィア生体膜研究所

Education 1

Tohoku University　Faculty of Medicine

- 1982/03/31

Committee Memberships 41

一般社団法人日本小児神経外科学会　理事

2017/05 - Present
一般社団法人日本神経内視鏡学会　理事

2017/01 - Present
一般社団法人日本脳卒中の外科学会　理事長

2015/05 - Present
一般社団法人脳神経外科手術と機器学会　理事

2015 - Present
一般社団法人日本脳ドック学会　理事

2010/01 - Present
一般社団法人日本神経外傷学会　理事

2010 - Present
一般社団法人日本脳卒中学会　理事

2009/03 - Present
社団法人日本脳神経外科学会　理事

2007/04 - Present
一般社団法人日本脳神経外科学会　理事

2007/04 - Present
日本脳循環代謝学会　理事

2006/11 - Present
日本脳循環代謝学会　理事

2006/11 - Present
日本頭蓋底外科学会　理事

2006/01 - Present
日本頭蓋底外科学会　理事

2006/01 - Present
日本脊髄障害医学学会　評議員

2005/11 - Present
日本脊髄障害医学学会　評議員

2005/11 - Present
日本脳腫瘍病理学会　理事

2005/08 - Present
日本脳腫瘍病理学会　理事

2005/08 - Present
日本意識障害学会　評議員

2005/07 - Present
日本意識障害学会　評議員

2005/07 - Present
社団法人日本脳卒中学会　理事

2005/04 - Present
社団法人日本脳ドック学会　理事

2005/04 - Present
社団法人日本神経外傷学会　理事

2005/04 - Present
日本小児神経外科学会　理事

2004/08 - Present
日本・定位機能神経外科学会　理事

2004/04 - Present
日本血管内治療学会　評議員

2004/04 - Present
日本神経内視鏡学会　理事

2004/04 - Present
社団法人日本脳腫瘍の外科学会　理事

2004/04 - Present
日本血管内治療学会　評議員

2004/04 - Present
株式会社医学書院　編集委員

2003/12 - Present
株式会社医学書院　編集委員

2003/12 - Present
一般社団法人日本脳腫瘍の外科学会　理事

2003/11 - Present
社団法人日本脳卒中の外科学会　理事

2003/05 - Present
日本脊髄外科学会　理事

2003/04 - Present
日本脊髄外科学会　理事

2003/04 - Present
日本てんかん外科学会　世話人

2001/04 - Present
アクテリオンファーマシューティカルズジャパン　医学専門家

2008/07 - 2012/03
アクテリオンファーマシューティカルズジャパン　医学専門家

2008/07 - 2012/03
日本間脳下垂体腫瘍学会　理事

2006/02 - 2008/03
日本間脳下垂体腫瘍学会　理事

2006/02 - 2008/03
日本ＮＯ学会　評議員

2004/04 - 2008/03
日本ＮＯ学会　評議員

2004/04 - 2008/03

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Professional Memberships 33

東北脳血管障害研究会(2003/12- 世話人)
東北脊髄外科研究会(2006/02- 世話人代表)
社団法人日本脳神経外科学会東北支部(2003/09-2009/01 支部長)
日本脳腫瘍病理学会(2005/08- 理事)
日本脊髄障害医学学会(2005/11- 評議員)
日本小児神経外科学会(2004/08- 理事)
日本脳神経CI学会(2004/04- 世話人)
日本脳神経外科光線力学研究会(2007/03- 運営委員)
日本間脳下垂体腫瘍学会(2006/02-2008/03 理事)
社団法人日本脳神経外科学会(2007/04- 理事)
日本意識障害学会(2005/07- 評議員)
日本ヒト脳機能マッピング学会(2005/04- 運営委員)
社団法人日本神経外傷学会(2005/04- 理事)
脳神経外科手術と機器学会(2005/04- 運営委員)
日本老年脳神経外科学会(2004/04- 世話人)
日本分子脳神経外科学会(2004/04- シニア世話人)
社団法人日本脳ドック学会(2005/04- 理事)
社団法人日本脳卒中の外科学会(2003/05- 理事)
社団法人日本脳卒中学会(2005/04- 理事)
日本脳神経外科コンピュータ研究会(2003/05-2009/01 世話人)
日本脳神経外科コングレス(2003/05- 運営委員)
日本脳循環代謝学会(2006/11- 理事)
社団法人日本脳腫瘍の外科学会(2004/04- 理事)
東北脳腫瘍研究会(2003/03- 世話人代表)
日本てんかん外科学会(2001/04- 世話人)
日本定位・機能神経外科学会(2004/04- 運営委員)
日本脊髄外科学会(2003/04- 理事)
日本生体磁気学会(2004/04- 評議員)
日本頭蓋底外科学会(2006/01- 理事)
日本神経内視鏡学会(2004/04- 理事)
日本血管内治療学会(2004/04- 評議員)
日本ＮＯ学会(2004/04-2008/03 評議員)
スパズムシンポジウム(2004/04- 世話人)

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Research Interests 1

neurosurgery

Research Areas 1

Life sciences / Neurosurgery /

Papers 552

Incidence of initial spinal metastasis in glioblastoma patients and the importance of spinal screening using MRI. International-journal Peer-reviewed

Ichiyo Shibahara, Ryuta Saito, Yoshinari Osada, Masayuki Kanamori, Yukihiko Sonoda, Toshihiro Kumabe, Shunji Mugikura, Mika Watanabe, Teiji Tominaga

Journal of neuro-oncology　141　(2)　337-345　2019/01

DOI： 10.1007/s11060-018-03036-4 　

ISSN： 0167-594X

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PURPOSE: Intracranial glioblastomas with simultaneous spinal lesions prior to chemoradiation therapy or craniotomy, defined as initial spinal metastasis, are not well understood. Herein, we investigated intracranial glioblastoma and demonstrated the importance of spinal screening using gadolinium enhanced spinal magnetic resonance imaging (Gd-MRI). METHODS: Consecutive adult patients with intracranial glioblastoma were treated between 2010 and 2014 and received spinal screening using Gd-MRI. Spinal screening was performed regardless of spine-related symptoms, and patients presenting with and without initial spinal metastasis (spinal and non-spinal groups, respectively) were compared based on patient demographics, tumor characteristics, radiological and molecular features, and overall survival (OS). RESULTS: During the study period, 116 glioblastoma cases were treated and 87 of these (76%) underwent spinal screening. Among these patients, 11 (13%) were included in the spinal group, and 76 (87%) were included in the non-spinal group. All patients of the spinal group were free of symptoms related to spinal lesions. Compared with the non-spinal group, intracranial lesions of the spinal group presented higher incidences of intracranial dissemination and were located at subventricular zones (P = 0.0012 and 0.020, respectively). MIB-1 labeling index, molecular alterations such as IDH1 mutation, TERT promoter mutation, and immunoreactivity of ATRX and MGMT did not differ between two groups. OS was significantly shorter in the spinal group than in the non-spinal group (P = 0.0054). CONCLUSIONS: This study revealed a relatively high incidence of spinal metastasis. A subset of glioblastoma patients benefited from spinal screening, through which early detection of asymptomatic spinal metastasis was achieved.
Early BBB breakdown and subacute inflammasome activation and pyroptosis as a result of cerebral venous thrombosis. Peer-reviewed

Rashad S, Niizuma K, Sato-Maeda M, Fujimura M, Mansour A, Endo H, Ikawa S, Tominaga T

Brain research　1699　54-68　2018/11

DOI： 10.1016/j.brainres.2018.06.029 　

ISSN： 0006-8993
Biphasic Development of Focal Cerebral Hyperperfusion After Revascularization Surgery for Adult Moyamoya Disease Associated With Autosomal Dominant Polycystic Kidney Disease. International-journal Peer-reviewed

Tashiro R, Fujimura M, Endo H, Endo T, Niizuma K, Tominaga T

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association　27　(11)　3256-3260　2018/11

DOI： 10.1016/j.jstrokecerebrovasdis.2018.07.024 　

ISSN： 1052-3057

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BACKGROUND: Cerebral hyperperfusion (CHP) syndrome is a potential complication of superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis for moyamoya disease (MMD), but its biphasic and delayed development is extremely rare. CASE REPORT: A 47-year-old woman with autosomal dominant kidney disease (ADPKD) presented with transient ischemic attacks due to MMD, and underwent left STA-MCA anastomosis. N-isopropyl-p-[123I] iodoamphetamine single-photon emission computed tomography (123IMP-SPECT) 1 day after surgery revealed asymptomatic CHP at the site of anastomosis. Strict blood pressure control and minocycline hydrochloride relieved CHP at postoperative day 7. However, 2 days later, the patient complained of sensory aphasia, and 123IMP-SPECT demonstrated significant focal CHP at the site of anastomosis accompanying high-intensity signal on magnetic resonance (MR) imaging of fluid attenuated inversion recovery (FLAIR) in her left temporal lobe near the site of anastomosis. We continued strict blood pressure control and additionally administered free radical scavenger (Edaravone) and antiepileptic agents, which gradually improved sensory aphasia. MR imaging and 123IMP-SPECT also confirmed the amelioration of the FLAIR-high lesion and focal CHP in her left temporal lobe. Two months later, the patient underwent right STA-MCA anastomosis without complications. CONCLUSIONS: Although the underlying mechanism is unknown, biphasic development of focal CHP after revascularization surgery in an MMD patient with ADPKD is unique. Due to the potential vulnerability of the systemic vessels in ADPKD, it is conceivable that intrinsic vascular wall fragility in MMD could be enhanced by ADPKD and have partly led to this rare complication.
Growth of Thrombosed Cerebral Venous Varix Following Resection of Cerebral Arteriovenous Malformation: Case Report with Pathologic Consideration. Peer-reviewed

Haryu S, Endo H, Endo T, Sato K, Fujimura M, Tominaga T

World neurosurgery　119　274-277　2018/11

DOI： 10.1016/j.wneu.2018.08.072 　

ISSN： 1878-8750
Hemorrhagic Moyamoya Disease : A Recent Update. Peer-reviewed

Fujimura M, Tominaga T

Journal of Korean Neurosurgical Society　2018/11

DOI： 10.3340/jkns.2018.0101 　

ISSN： 2005-3711
Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels as a Biomarker of Acute Intracerebral Hemorrhage. Peer-reviewed

Inoue T, Ishida T, Inoue T, Saito A, Ezura M, Uenohara H, Fujimura M, Sato K, Endo T, Omodaka S, Endo H, Niizuma K, Tominaga T

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association　28　(2)　490-494　2018/11
Publisher: Elsevier BV
DOI： 10.1016/j.jstrokecerebrovasdis.2018.10.027 　

ISSN： 1052-3057
Spontaneous Development of Encapsulated Subdural Hematoma in the Posterior Cranial Fossa after Cardiac Surgery: A Case Report. Peer-reviewed

Kochi R, Mino M, Sonobe S, Yoshida M, Tominaga T

NMC case report journal　5　(4)　87-90　2018/10

DOI： 10.2176/nmccrj.cr.2017-0230 　
Effects of a Novel Piezo Actuator-Driven Pulsed Water Jet System on Residual Kidney after Partial Nephrectomy in a Rat Model. Peer-reviewed

Kamiyama Y, Yamashita S, Nakagawa A, Fujii S, Goto T, Mitsuzuka K, Ito A, Abe T, Tominaga T, Arai Y

Urology　2018/10

DOI： 10.1016/j.urology.2018.10.014 　

ISSN： 0090-4295
Stress-induced tRNA cleavage and tiRNA generation in rat neuronal PC12 cells. International-journal Peer-reviewed

Alaa Elkordy, Eikan Mishima, Kuniyasu Niizuma, Yasutoshi Akiyama, Miki Fujimura, Teiji Tominaga, Takaaki Abe

Journal of neurochemistry　146　(5)　560-569　2018/09

DOI： 10.1111/jnc.14321 　

ISSN： 0022-3042

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Transfer RNA (tRNA) plays a role in stress response programs involved in various pathological conditions including neurological diseases. Under cell stress conditions, intracellular tRNA is cleaved by a specific ribonuclease, angiogenin, generating tRNA-derived fragments or tRNA-derived stress-induced RNA (tiRNA). Generated tiRNA contributes to the cell stress response and has potential cell protective effects. However, tiRNA generation under stress conditions in neuronal cells has not been fully elucidated. To examine angiogenin-mediated tiRNA generation in neuronal cells, we used the rat neuronal cell line, PC12, in combination with analysis of SYBR staining and immuno-northern blotting using anti-1-methyladenosine antibody, which specifically and sensitively detects tiRNA. Oxidative stress induced by arsenite and hydrogen peroxide caused tRNA cleavage and tiRNA generation in PC12 cells. We also demonstrated that oxygen-glucose deprivation, which is an in vitro model of ischemic-reperfusion injury, induced tRNA cleavage and tiRNA generation. In these stress conditions, the amount of generated tiRNA was associated with the degree of morphological cell damage. Time course analysis indicated that generation of tiRNA was prior to severe cell damage and cell death. Angiogenin over-expression did not influence the amount of tiRNA in normal culture conditions; however, it significantly increased tiRNA generation induced by cell stress conditions. Our findings show that angiogenin-mediated tiRNA generation can be induced in neuronal cells by different cell stressors, including ischemia-reperfusion. Additionally, detection of tiRNA could be used as a potential cell damage marker in neuronal cells. Cover Image for this issue: doi: 10.1111/jnc.14191.
Continuous Minor Bleeding from Tumor Surface in Patients with Craniopharyngiomas: Case Series of Nonobstructive Hydrocephalus. Peer-reviewed

Shoji T, Kawaguchi T, Ogawa Y, Watanabe M, Fujimura M, Tominaga T

Journal of neurological surgery. Part A, Central European neurosurgery　79　(5)　436-441　2018/09

DOI： 10.1055/s-0038-1646957 　

ISSN： 2193-6315
SMART (stroke-like migraine attacks after radiation therapy) syndrome responded to steroid pulse therapy: Report of a case and review of the literature. International-journal Peer-reviewed

Wenting Jia, Ryuta Saito, Masayuki Kanamori, Naoya Iwabuchi, Masaki Iwasaki, Teiji Tominaga

eNeurologicalSci　12　1-4　2018/09

DOI： 10.1016/j.ensci.2018.05.003 　

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This report presents a case of stroke-like migraine attacks after radiation therapy (SMART) syndrome in a 31-year-old man in whom symptoms and radiological findings resolved with steroid pulsed therapy and reviews the literatures with special emphasis on the use of steroids against SMART syndrome. The patient had a past history of left temporal anaplastic astrocytoma and was treated with surgery followed by local 72 Gy radiation therapy and chemotherapy using Nimustine Hydrochloride. Four years after the surgery, he was suffering from subacute progressing symptoms of headache, right hemianopia, right hemiparesis and aphasia from 2 to 4 days before admission to our hospital. At first he was diagnosed as symptomatic epilepsy but after extensive examination, the final diagnosis was SMART syndrome. His symptoms soon improved with steroid pulse therapy. In the literature, steroid pulse therapy is not necessarily a standard of care for SMART syndrome, but it seemed to decrease the need of biopsy. As the lesions of SMART syndrome require differential diagnosis from recurrences, biopsy was performed in some cases. However, lack of benefit and possible detriment is reported with biopsy of SMART lesions. Through this experience we suggest that steroid pulse therapy may provide speedy recovery from symptoms, and it should be considered before other invasive investigations or treatments.
Metabolomic Analysis of Mouse Brain after a Transient Middle Cerebral Artery Occlusion by Mass Spectrometry Imaging. Peer-reviewed

Abe T, Niizuma K, Kanoke A, Saigusa D, Saito R, Uruno A, Fujimura M, Yamamoto M, Tominaga T

Neurologia medico-chirurgica　58　(9)　384-392　2018/09

DOI： 10.2176/nmc.oa.2018-0054 　

ISSN： 0470-8105

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We performed metabolomic analyses of mouse brain using a transient middle cerebral artery occlusion (tMCAO) model with Matrix Assisted Laser Desorption/Ionization (MALDI)-mass spectrometry imaging (MSI) to reveal metabolite changes after cerebral ischemia. We selected and analyzed three metabolites, namely creatine (Cr), phosphocreatine (P-Cr), and ceramides (Cer), because these metabolites contribute to cell life and death. Eight-week-old male C57BL/6J mice were subjected to tMCAO via the intraluminal blockade of the middle cerebral artery (MCA) and reperfusion 60 min after the induction of ischemia. Each mouse was randomly assigned to one of the three groups; the groups were defined by the survival period after reperfusion: control, 1 h, and 24 h. Corrected samples were analyzed using MALDI-MSI. Results of MSI analysis showed the presence of several ionized substances and revealed spatial changes in some metabolites identified as precise substances, including Cr, P-Cr, Cer d18:1/18:0, phosphatidylcholine, L-glutamine, and L-histidine. Cr, P-Cr, and Cer d18:1/18:0 were changed after tMCAO, and P-Cr and Cer d18:1/18:0 accumulated over time in ischemic cores and surrounding areas following ischemia onset. The upregulation of P-Cr and Cer d18:1/18:0 was detected 1 h after tMCAO when no changes were evident on hematoxylin and eosin staining and immunofluorescence assay. P-Cr and Cer d18:1/18:0 can serve as neuroprotective therapies because they are biomarker candidates for cerebral ischemia.
A refined model of chronic cerebral hypoperfusion resulting in cognitive impairment and a low mortality rate in rats. Peer-reviewed

Mansour A, Niizuma K, Rashad S, Sumiyoshi A, Ryoke R, Endo H, Endo T, Sato K, Kawashima R, Tominaga T

Journal of neurosurgery　1-11　2018/09

DOI： 10.3171/2018.3.JNS172274 　

ISSN： 0022-3085
Surgical strategy for an adult patient with a catecholamine-producing ganglioneuroblastoma and a cerebral aneurysm: a case report. International-journal Peer-reviewed

Kumata H, Nishimura R, Nakanishi C, Inoue C, Tezuka Y, Endo H, Miyagi S, Tominaga T, Unno M, Kamei T

Surgical case reports　4　(1)　119-119　2018/09

DOI： 10.1186/s40792-018-0529-x 　

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BACKGROUND: Ganglioneuroblastomas, particularly those that produce catecholamine, are extremely rare in adults. Here, we report an interesting surgical case of an adult patient with a catecholamine-producing ganglioneuroblastomas in her adrenal gland, suspected to be a pheochromocytoma, and with a cerebral aneurysm. CASE PRESENTATION: The patient was a 73-year-old woman under treatment for hypertension. During a health check-up, a cystic retroperitoneal tumor was incidentally found in the superior pole of her right kidney. Her blood adrenaline level was slightly elevated, and her urinary adrenaline, noradrenaline, and dopamine levels were above the upper reference limits. In addition, 24-h urinary excretion of metanephrine, normetanephrine, and vanillylmandelic acid were all increased. 123I-Meta-iodobenzylguanidine scintigraphy showed an abnormal accumulation of the marker in the cyst wall. She was, therefore, diagnosed with a pheochromocytoma and scheduled for tumor resection. However, preoperatively, 8-mm-diameter cerebral aneurysm was incidentally found in her basilar artery. This required careful preoperative discussion. The aneurysm was difficult to approach and treat, and based on its position, shape, and size, the risk of rupture was low. Because hypertension is a major risk factor for aneurysmal rupture, we decided to proceed with the tumor resection. A lumbar catheter was placed to monitor the cerebral aneurysm for intraoperative rupture, and her transcranial motor-evoked potential and somatosensory-evoked potentials were monitored to track her intraoperative neurological function. During surgery, we carefully monitored fluctuations in blood pressure and resected the tumor with minimal mobilization. Postoperatively, head computed tomography confirmed that there was no sign of rupture. Histopathologically, the tumor was diagnosed as a catecholamine-producing ganglioneuroblastoma. The postoperative course was good, and the patient's blood pressure improved. CONCLUSIONS: Careful perioperative management is needed for a patient with both a catecholamine-producing tumor and cerebral aneurysm.
[Safety and Efficacy of Keishi-Bukuryo-Gan in Patients with Spontaneous Intracerebral Hemorrhage during the Acute Period:CT Image-Based Analysis of the Clearance of Hematoma]. Peer-reviewed

Osawa SI, Endo H, Kawamura T, Tominaga T

No shinkei geka. Neurological surgery　46　(9)　763-770　2018/09

DOI： 10.11477/mf.1436203810 　

ISSN： 0301-2603

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BACKGROUND: Keishi-Bukuryo-Gan(KBG)is a traditional Japanese(Kampo)formula used to improve microcirculation and a congestive condition called "Oketsu". KBG is also used to prevent the development of atherosclerosis. Many patients with intracerebral hemorrhage(ICH)have comorbid diseases related to atherosclerosis;thus, KBG may be a treatment option for ICH. OBJECTIVE: The aim of this study was to investigate whether the administration of KBG in patients with ICH during the acute phase affects the course of absorption of ICH, detected using computed tomography(CT). MATERIAL AND METHODS: We identified 308 patients with ICH who were diagnosed and treated at our institution from April 2013 to June 2016. Among them, 53 patients were chosen based on the accessibility of CT images, patient background, and past history. The volume and CT value of the hematoma were analyzed at admission, one week(six to eight days)after admission, and two weeks(thirteen to sixteen days)after admission. RESULTS: There were no significant differences between KBG and non-KBG patients in terms of the background parameters, hematoma volume, or CT value at admission. However, there were significant differences in both the volume reduction ratio(non-KBG=64.3±8.4%, KBG=48.5±14.5%, p=0.03)and CT value(non-KBG=48.5±4.6HU, KBG=44.0±7.0HU, p=0.04)two weeks after admission. CONCLUSION: Significant improvement in the absorption of ICH was observed in KBG patients. To our knowledge, this is the first report that shows the facilitative effect of KBG on intracranial hematoma clearance during the acute phase.
Paradoxical Association of Symptomatic Local Vasogenic Edema with Global Cerebral Hypoperfusion after Direct Revascularization Surgery for Adult Moyamoya Disease. International-journal Peer-reviewed

Tashiro R, Fujimura M, Mugikura S, Niizuma K, Endo H, Endo T, Tominaga T

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association　27　(8)　e172-e176　2018/08

DOI： 10.1016/j.jstrokecerebrovasdis.2018.03.002 　

ISSN： 1052-3057

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BACKGROUND: Superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis is the standard treatment for Moyamoya disease (MMD). Cerebral hyperperfusion syndrome is a potential complication of this procedure and can cause local vasogenic edema and/or delayed intracerebral hemorrhage. Cerebral hypoperfusion is a contradictory postoperative pathophysiological condition implicated in MMD, but its association with symptomatic local vasogenic edema has not been reported. CASE REPORT: A 31-year-old woman with MMD underwent left STA-MCA anastomosis 3 months after a minor completed stroke in bilateral hemispheres. Eight hours after the operation, the patient developed neurological deterioration of dysarthria and mono-paresis in her right hand. Magnetic resonance (MR) angiography showed apparently patent STA-MCA bypass, whereas MR imaging of fluid-attenuated inversion recovery demonstrated a local high-signal-intensity lesion at the vascular territory supplied by the bypass. The apparent diffusion coefficient value was significantly increased in this lesion, suggesting local vasogenic edema formation. N-isopropyl-p-[123I] iodoamphetamine single-photon emission computed tomography revealed global hypoperfusion in the left hemisphere. The administration of a free-radical scavenger and antiepileptic agent gradually relieved her symptoms, and MR imaging 1 month after surgery confirmed the complete disappearance of local vasogenic edema. CONCLUSIONS: Vasogenic edema may be associated not only with cerebral hyperperfusion but also with hypoperfusion after STA-MCA anastomosis for MMD. Although the exact mechanism of this rare association is unknown, the intrinsic vulnerability of intracranial vascular wall structures and the increased vascular permeability in MMD may partly explain the paradoxical association of hypoperfusion and local vasogenic edema.
Intracellular S1P Levels Dictate Fate of Different Regions of the Hippocampus following Transient Global Cerebral Ischemia Peer-reviewed

Sherif Rashad, Kuniyasu Niizuma, Daisuke Saigusa, Xiaobo Han, Mika Sato-Maeda, Ritsumi Saito, Akira Uruno, Miki Fujimura, Shuntaro Ikawa, Masayuki Yamamoto, Teiji Tominaga

Neuroscience　384　188-202　2018/08/01
Publisher: Elsevier Ltd
DOI： 10.1016/j.neuroscience.2018.05.015 　

ISSN： 1873-7544 0306-4522
Lumbar tap-induced subarachnoid hemorrhage in a case of spinal epidural arteriovenous fistula. Peer-reviewed

Kajitani T, Endo T, Inoue T, Sato K, Matsumoto Y, Tominaga T

Journal of neurosurgery. Spine　1-6　2018/08

DOI： 10.3171/2018.3.SPINE171343 　

ISSN： 1547-5654
[Surgical Planning for a Giant Pituitary Adenoma Based on Evaluation of the Fine Feeding System and Angioarchitecture:A Case Report]. Peer-reviewed

Aburakawa D, Ogawa Y, Sato K, Niizuma K, Tominaga T

No shinkei geka. Neurological surgery　46　(8)　691-697　2018/08

DOI： 10.11477/mf.1436203795 　

ISSN： 0301-2603
Water Veil Effect to Control Splashing from the Pulsed Water Jet Device: Minimizing the Potential Risk of Dissemination Using Surgical Aspirators. International-journal Peer-reviewed

Atsushi Nakayashiki, Tomohiro Kawaguchi, Atsuhiro Nakagawa, Motohiko Sato, Fusako Mochizuki, Toshiki Endo, Teiji Tominaga

Journal of neurological surgery. Part A, Central European neurosurgery　79　(4)　309-315　2018/07

DOI： 10.1055/s-0037-1608836 　

ISSN： 2193-6315

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OBJECTIVE: Maximum resection with minimum damage to normal structures is required for a better clinical outcome. Several efficient surgical devices such as the Cavitron ultrasonic surgical aspirator are available. Our group developed the actuator-driven pulsed water jet (ADPJ) to dissect soft tissue with vessel preservation. Although these devices are very effective for resection, tumor seeding is a potential risk. The present study investigated the control of splashing during ADPJ use. We demonstrate the effect of additional water flow around the instrument tip to veil the splashing. METHODS: Pulsed water jet was ejected from the tip of the ADPJ nozzle. Effects of ADPJ parameters such as input voltage, suction pressure, and distance between the nozzle and the target (standoff distance) on the amount of splashing were analyzed. Methylene blue solution was ejected on photo paper, gelatin brain phantom, and porcine brain harvested and subsequently immersed into physiologic saline to quantify the amount of splashing. RESULTS: High-input voltage and a long standoff distance had significant correlations with large amounts of splashing (r > 0.5; p < 0.01). However, suction pressure had no correlation (r = 0.23). Additional water flow combined with the ADPJ decreased the amount of splashing. A high-speed camera recording revealed that the additional water flow formed a water veil that prevented droplet dispersion, as confirmed with experiments using the brain phantom and porcine brain, in which the irregularity and elasticity are specific. CONCLUSIONS: The veil effect of additional water flow is important to reduce splashing during ADPJ use and can minimize the potential risk of dissemination and enhance the safety of the ADPJ.
Indications for salvage surgery during treatment for intracranial germ cell tumors. International-journal Peer-reviewed

Masayuki Kanamori, Toshihiro Kumabe, Mika Watanabe, Masashi Chonan, Ryuta Saito, Yoji Yamashita, Yoshikazu Ogawa, Yukihiko Sonoda, Teiji Tominaga

Journal of neuro-oncology　138　(3)　601-607　2018/07

DOI： 10.1007/s11060-018-2827-3 　

ISSN： 0167-594X

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This study retrospectively reviewed our single institute experience to clarify the optimal indication and timing of salvage surgery. Retrospective analysis of 159 consecutive cases with germ cell tumors identified 20 cases with salvage surgery. These cases were classified based on the radiological response to neoadjuvant treatment before salvage surgery into increase (growing group, five cases), no change (stable group, seven cases), and decrease (shrinkage group, eight cases) in tumor size. Changes in tumor markers, histological findings, and the pattern of failure after salvage surgery were reviewed. Growing teratoma syndrome (GTS) is defined as enlargement of tumor consisting of mature teratoma after chemotherapy with normalization of tumor markers. In growing group, two cases presented GTS, whereas other three cases did not fulfill the criteria for GTS. All cases in stable and shrinkage group had elevated levels of tumor markers at presentation and decreased levels after neoadjuvant treatment. Histologically, sparse components of mature teratoma with extensive fibrosis were found in cases with GTS and seven of eight cases in shrinkage group, whereas mature teratoma without fibrosis was found in six of seven cases in stable group. Six cases recurred after salvage surgery. We identified three factors as risks for recurrence after salvage surgery, as follows: (1) growing lesion which did not fulfill the criteria for GTS, (2) non-normalized level of tumor marker before salvage surgery, and (3) residual germinoma component. In conclusion, salvage surgery is recommended for patients with GTS, or with normalized tumor markers in stable or shrinkage group.
Bilateral Upper Cerebellar Hemorrhage Due to Pial Arteriovenous Fistula and Its Pathophysiological Insight Peer-reviewed

Yosuke Akamatsu, Toshiaki Hayashi, Kenichi Sato, Hiroshi Karibe, Motonobu Kameyama, Teiji Tominaga

World Neurosurgery　115　388-392　2018/07/01
Publisher: Elsevier Inc.
DOI： 10.1016/j.wneu.2018.05.010 　

ISSN： 1878-8769 1878-8750
Application of actuator-driven pulsed water jet for coronary artery bypass grafting: assessment in a swine model Peer-reviewed

Tomoyuki Suzuki, Shunsuke Kawamoto, Atsuhiro Nakagawa, Toshiki Endo, Teiji Tominaga, Masatoshi Akiyama, Osamu Adachi, Kiichiro Kumagai, Yoshikatsu Saiki

Journal of Artificial Organs　21　(2)　247-253　2018/06/01
Publisher: Springer Tokyo
DOI： 10.1007/s10047-017-1008-z 　

ISSN： 1619-0904 1434-7229
Cervical Periosteal Chondroma Causing Spinal Cord or Nerve Compression: 2 Case Reports and Literature Review Peer-reviewed

Tomoo Inoue, Yukoh Ohara, Tadaaki Niiro, Toshiki Endo, Teiji Tominaga, Jyun-ichi Mizuno

World Neurosurgery　114　99-105　2018/06/01
Publisher: Elsevier Inc.
DOI： 10.1016/j.wneu.2018.03.052 　

ISSN： 1878-8769 1878-8750

eISSN： 1878-8769
Posterior cerebral artery stenosis and posterior circulation revascularization surgery in pediatric patients with moyamoya disease Peer-reviewed

Tomomi Kimiwada, Toshiaki Hayashi, Reizo Shirane, Teiji Tominaga

Journal of Neurosurgery: Pediatrics　21　(6)　632-638　2018/06/01
Publisher: American Association of Neurological Surgeons
DOI： 10.3171/2018.1.PEDS17367 　

ISSN： 1933-0715 1933-0707
[Two Craniotomies with Retained Cotton Patties:Is Their Retrieval Necessary?] Peer-reviewed

Shimizu S, Mano Y, Kumabe T, Tominaga T, Nakayama K, Yamamoto I

No shinkei geka. Neurological surgery　46　(6)　529-533　2018/06

DOI： 10.11477/mf.1436203763 　

ISSN： 0301-2603
Circumferential Wall Enhancement on Magnetic Resonance Imaging is Useful to Identify Rupture Site in Patients with Multiple Cerebral Aneurysms. Peer-reviewed

Omodaka S, Endo H, Niizuma K, Fujimura M, Endo T, Sato K, Sugiyama SI, Inoue T, Tominaga T

Neurosurgery　82　(5)　638-644　2018/05

DOI： 10.1093/neuros/nyx267 　

ISSN： 0148-396X
Clinical Features of Precocious, Synchronous, and Metachronous Brain Metastases and the Role of Tumor Resection. International-journal Peer-reviewed

Ichiyo Shibahara, Masayuki Kanamori, Takashi Watanabe, Akihiro Utsunomiya, Hiroyoshi Suzuki, Ryuta Saito, Yukihiko Sonoda, Hidefumi Jokura, Hiroshi Uenohara, Teiji Tominaga

World neurosurgery　113　e1-e9-e9　2018/05

DOI： 10.1016/j.wneu.2017.10.145 　

ISSN： 1878-8750

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OBJECTIVE: The purpose of this study was to clarify clinical features, outcomes, and the role of tumor resection in precocious, synchronous, and metachronous brain metastases. METHODS: Brain metastases were found before primary cancer detection in the precocious group, within 2 months after primary cancer detection in the synchronous group, and 2 months or later after primary cancer detection in the metachronous group. RESULTS: Of 471 patients with brain metastases, 93 (20%) were included in the precocious group, 76 (16%) in the synchronous group, and 302 (64%) in the metachronous group. The precocious group tended to be symptomatic, show a low Karnofsky Performance Status, and have a large single tumor, infrequent extracranial metastases, and frequent tumor resection compared with the other 2 groups. There were no differences in overall survival from the detection of brain metastases among the 3 groups in univariate and multivariate analyses. Of 471 cases, 97 (21%) underwent surgeries. Among this surgical cohort, overall survival from surgery was significantly shorter in the precocious group than in the metachronous group (P = 0.039). After adjustment for age, sex, tumor size, primary cancer, and the Graded Prognostic Assessment score, the hazard ratio for metachronous metastases was 0.52 (confidence interval, 0.29-0.95; P = 0.035). CONCLUSIONS: The timing of brain metastasis diagnosis is not a modifiable factor but affects patient demographics and treatment strategies. In particular, the precocious group is a unique subset of brain metastases that require special consideration during clinical decision making.
Mid-term prognosis of non-functioning pituitary adenomas with high proliferative potential: really an aggressive variant? Peer-reviewed

Yoshikazu Ogawa, Hidefumi Jokura, Kuniyasu Niizuma, Teiji Tominaga

Journal of Neuro-Oncology　137　(3)　543-549　2018/05/01
Publisher: Springer New York LLC
DOI： 10.1007/s11060-017-2740-1 　

ISSN： 1573-7373 0167-594X
Marked effectiveness of low-dose oral methotrexate for steroid-resistant idiopathic hypertrophic pachymeningitis: Case report Peer-reviewed

Hiroki Uchida, Yoshikazu Ogawa, Teiji Tominaga

Clinical Neurology and Neurosurgery　168　30-33　2018/05/01
Publisher: Elsevier B.V.
DOI： 10.1016/j.clineuro.2018.02.035 　

ISSN： 1872-6968 0303-8467
Endovascular Treatments in Combination with Extracranial-Intracranial Bypass for Complex Intracranial Aneurysms Peer-reviewed

Kenichi Sato, Hidenori Endo, Miki Fujimura, Toshiki Endo, Yasushi Matsumoto, Hiroaki Shimizu, Teiji Tominaga

World Neurosurgery　113　e747-e760　2018/05/01
Publisher: Elsevier Inc.
DOI： 10.1016/j.wneu.2018.02.143 　

ISSN： 1878-8769 1878-8750
Intrinsic development of choroidal and thalamic collaterals in hemorrhagic-onset moyamoya disease: case-control study of the Japan Adult Moyamoya Trial. Peer-reviewed

Fujimura M, Funaki T, Houkin K, Takahashi JC, Kuroda S, Tomata Y, Tominaga T, Miyamoto S, Japan Adult, Moyamoya Trial Investigators

Journal of neurosurgery　1-7　2018/05

DOI： 10.3171/2017.11.JNS171990 　

ISSN： 0022-3085
[A Case of Ventriculoperitoneal Shunt Dysfunction in an Adult Secondary to Constipation]. Peer-reviewed

Nakamura L, Saito R, Kanamori M, Morita T, Tashiro R, Tominaga T

No shinkei geka. Neurological surgery　46　(5)　385-389　2018/05

DOI： 10.11477/mf.1436203739 　

ISSN： 0301-2603

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INTRODUCTION: Ventriculoperitoneal(VP)shunts function because of the pressure differential between the intracranial space and the peritoneal cavity. Although chronic constipation is often a cause of VP shunt dysfunction in children, it is not well recognized in adults. We present a case of shunt dysfunction that not only resolved after resolution of constipation but also resulted in overdrainage. CASE REPORT: A 28-year-old woman who had a VP shunt placed 11 years prior for hydrocephalus was referred to our department because of an enlarged ventricle diagnosed with computed tomography(CT). She had a previous history of pineal germinoma and a VP shunt was placed to treat the associated hydrocephalus. At presentation, she complained of headache and somnolence. Shunt dysfunction was suspected, but no problem was detected in the shunt system, including pressure settings. As constipation was detected, we treated this condition. Soon after, her symptoms resolved and ventricle size normalized. She was discharged without any deficit, but overdrainage was detected with CT obtained 1 month later. CONCLUSION: Although constipation is not a common cause of shunt dysfunction in adult patients, it is important to consider to avoid unnecessary shunt revision. In the present case, resolution of chronic constipation resulted in resolution of shunt dysfunction. This suggests the importance of resolution of constipation in case of shunt adjustment, even in adult cases.
Parapharyngeal neuroglial heterotopia appearing as high uptake on 18F–FDG PET: case report and literature review of radiographical findings Peer-reviewed

Masayuki Kameyama, Tomohiro Kawaguchi, Hidetaka Niizuma, Takenori Ogawa, Kenichi Watanabe, Toshiaki Hayashi, Kanako Sato, Masayuki Kanamori, Mika Watanabe, Yukio Katori, Shigeo Kure, Teiji Tominaga

Acta Neurochirurgica　160　(4)　801-809　2018/04/01
Publisher: Springer-Verlag Wien
DOI： 10.1007/s00701-017-3403-x 　

ISSN： 0942-0940 0001-6268

eISSN： 0942-0940
Accelerating Cell Therapy for Stroke in Japan: Regulatory Framework and Guidelines on Development of Cell-Based Products. International-journal Peer-reviewed

Kiyohiro Houkin, Hideo Shichinohe, Koji Abe, Teruyo Arato, Mari Dezawa, Osamu Honmou, Nobutaka Horie, Yasuo Katayama, Kohsuke Kudo, Satoshi Kuroda, Tomohiro Matsuyama, Ichiro Miyai, Izumi Nagata, Kuniyasu Niizuma, Ken Sakushima, Masanori Sasaki, Norihiro Sato, Kenji Sawanobori, Satoshi Suda, Akihiko Taguchi, Teiji Tominaga, Haruko Yamamoto, Toru Yamashita, Toshiki Yoshimine

Stroke　49　(4)　e145-e152-e152　2018/04

DOI： 10.1161/STROKEAHA.117.019216 　

ISSN： 0039-2499
Three case reports of radiation-induced glioblastoma after complete remission of acute lymphoblastic leukemia. Peer-reviewed

Kajitani T, Kanamori M, Saito R, Watanabe Y, Suzuki H, Watanabe M, Kure S, Tominaga T

Brain tumor pathology　35　(2)　114-122　2018/04

DOI： 10.1007/s10014-018-0316-1 　

ISSN： 1433-7398
Rapid detection of mutation in isocitrate dehydrogenase 1 and 2 genes using mass spectrometry. Peer-reviewed

Masayuki Kanamori, Masamitsu Maekawa, Ichiyo Shibahara, Ryuta Saito, Masashi Chonan, Miki Shimada, Yukihiko Sonoda, Toshihiro Kumabe, Mika Watanabe, Nariyasu Mano, Teiji Tominaga

Brain tumor pathology　35　(2)　90-96　2018/04

DOI： 10.1007/s10014-018-0317-0 　

ISSN： 1433-7398

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The 2016 World Health Organization classification of tumors of the central nervous system was recently revised. Mutations in the isocitrate dehydrogenase 1 (IDH1) and IDH2 genes and chromosome 1p/19q codeletion are especially important for both the integrated diagnosis and the determination of surgical strategy. To establish a method for intraoperative molecular diagnosis, a simple, rapid method was developed for the measurement of 2-hydroxyglutarate (2-HG), a specific oncometabolite formed in the presence of IDH gene mutation, using liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS). This method requires only 10 min to measure the level of 2-HG from tissue preparation to completion of examination. Using this method, the level of 2-HG was analyzed in 105 patients with diffuse infiltrating glioma, and showed that IDH mutated glioma had significantly higher level of 2-HG compared to IDH wild-type glioma. Receiver operating characteristic curve analysis showed the area under the curve, sensitivity, and specificity were 0.9815, 97.5, and 100%, respectively. In contrast, tumor grade and presence of chromosome 1p/19q codeletion in the IDH mutated glioma could not be predicted from the level of 2-HG. Measurement of 2-HG level using LC/ESI-MS/MS can provide rapid and accurate information of mutation status in the IDH gene.
Impact of bifurcation angle and inflow coefficient on the rupture risk of bifurcation type basilar artery tip aneurysms Peer-reviewed

Sherif Rashad, Shin-Ichiro Sugiyama, Kuniyasu Niizuma, Kenichi Sato, Hidenori Endo, Shunsuke Omodaka, Yasushi Matsumoto, Miki Fujimura, Teiji Tominaga

Journal of Neurosurgery　128　(3)　723-730　2018/03/01
Publisher: American Association of Neurological Surgeons
DOI： 10.3171/2016.10.JNS161695 　

ISSN： 1933-0693 0022-3085
Newly Diagnosed Acquired Hemophilia A Manifesting as Massive Intracranial Hemorrhage Following a Neurosurgical Procedure Peer-reviewed

Yosuke Akamatsu, Toshiaki Hayashi, Joji Yamamoto, Hiroshi Karibe, Motonobu Kameyama, Teiji Tominaga

World Neurosurgery　111　175-180　2018/03/01
Publisher: Elsevier Inc.
DOI： 10.1016/j.wneu.2017.12.016 　

ISSN： 1878-8769 1878-8750
Minimally invasive surgical approach to filum sectioning: Technical note Peer-reviewed

Toshiaki Hayashi, Tomomi Kimiwada, Reizo Shirane, Teiji Tominaga

Operative Neurosurgery　14　(3)　315　2018/03/01
Publisher: Oxford University Press
DOI： 10.1093/ons/opx127 　

ISSN： 2332-4252
Clinical Characteristics of Lumbosacral Spinal Dural Arteriovenous Fistula (DAVF)–Comparison with Thoracic DAVF Peer-reviewed

Toshiki Endo, Takumi Kajitani, Tomoo Inoue, Kenichi Sato, Kuniyasu Niizuma, Hidenori Endo, Yasushi Matsumoto, Teiji Tominaga

World Neurosurgery　110　e383-e388　2018/02/01
Publisher: Elsevier Inc.
DOI： 10.1016/j.wneu.2017.11.002 　

ISSN： 1878-8769 1878-8750
Expression of CD133 as a Putative Prognostic Biomarker to Predict Intracranial Dissemination of Primary Spinal Cord Astrocytoma Peer-reviewed

Tomoo Inoue, Toshiki Endo, Taigen Nakamura, Ichiyo Shibahara, Hidenori Endo, Teiji Tominaga

World Neurosurgery　110　e715-e726　2018/02/01
Publisher: Elsevier Inc.
DOI： 10.1016/j.wneu.2017.11.089 　

ISSN： 1878-8769 1878-8750
[A Case of Hypertrophic Pachymeningitis with Symptomatic Venous Congestion due to Sinus Stenosis]. Peer-reviewed

Umegaki S, Osawa SI, Kimura K, Okushima T, Yajima N, Kawamura T, Tominaga T

No shinkei geka. Neurological surgery　46　(2)　147-152　2018/02

DOI： 10.11477/mf.1436203691 　

ISSN： 0301-2603

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We report a patient with hypertrophic pachymeningitis and symptomatic stenosis of the superior sagittal sinus. A 71-year-old man presented with right hemiparesis, sensory-dominant aphasia, and right hemispatial neglect that had been worsening over 2 weeks. Computed tomography showed isodense crescent-shaped lesions deforming the surface of the left cerebral hemisphere, mimicking a subdural hematoma with atypical perifocal edema in the left parietal lobe. Magnetic resonance imaging showed diffuse thickening of the dura mater with contrast enhancement of his left cerebral hemisphere. Histopathological examination of the dural specimen obtained by burr-hole surgery revealed mononuclear inflammatory cell infiltration, and he was diagnosed with hypertrophic pachymeningitis. Dynamic cerebral angiography showed superior sagittal sinus stenosis with reduced venous flow through the left parietal lobe. Administration of high-dose steroid therapy led to neurological improvement. In the case of a subdural mass with atypical parenchymal edema such as a chronic subdural hematoma, other etiology should be taken into consideration.
Increased serum production of soluble CD163 and CXCL5 in patients with moyamoya disease: Involvement of intrinsic immune reaction in its pathogenesis. International-journal Peer-reviewed

Miki Fujimura, Taku Fujimura, Aya Kakizaki, Mika Sato-Maeda, Kuniyasu Niizuma, Yasutake Tomata, Setsuya Aiba, Teiji Tominaga

Brain research　1679　39-44　2018/01/15

DOI： 10.1016/j.brainres.2017.11.013 　

ISSN： 0006-8993

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Moyamoya disease (MMD) is a rare cerebrovascular disease characterized by a progressive stenosis at the terminal portion of the internal carotid artery and an abnormal vascular network at the base of the brain. Although its etiology is still unknown, intrinsic immune reactions such as autoimmune response has been implicated in the pathogenesis of MMD. Recently, the RING finger protein 213 (RNF213) was found to be an important risk gene for MMD, and is predominantly expressed in blood cells and the spleen. Thus, we hypothesized that patients with MMD represent an intrinsic autoimmune status mediated by M2-polarized macrophages, which play an important role in tissue remodeling and angiogenesis. We compared the serum level of soluble (s)CD163, an activating marker for CD163+ M2-polarized macrophages that has been implicated in a variety of autoimmune disorders, between MMD patients and healthy controls. We also analyzed serum levels of CXCL5, an augmented cytokines that has been correlated with the severity of autoimmune diseases. As a result, the serum sCD163 levels of MMD patients (281,465 pg/ml) were significantly higher than those of healthy controls (174,842 pg/ml) (p = .004). The serum CXCL5 levels of MMD patients (679.02 pg/ml) were significantly higher than those of healthy controls (401.79 pg/ml) (p = .046). There were no differences in the serum sCD163 and CXCL5 levels between each genotype of the RNF213 polymorphism (wild-type or variant) among MMD patients. Although this is a pilot study and further validation with larger number of samples is necessary, our results indicate that patients with MMD may have increased autoimmune activity, and our results shed light on the pathogenesis of MMD via CD163+ M2-polarized macrophages.
Embolization of ruptured arteriovenous malformations in the cerebellopontine angle cistern Peer-reviewed

Hidenori Endo, Shin-ichiro Osawa, Yasushi Matsumoto, Toshiki Endo, Kenichi Sato, Kuniyasu Niizuma, Miki Fujimura, Teiji Tominaga

Neurosurgical Review　41　(1)　173-182　2018/01/01
Publisher: Springer Verlag
DOI： 10.1007/s10143-017-0832-1 　

ISSN： 1437-2320 0344-5607
A Case of Pituitary Carcinoma Initially Diagnosed as an Ectopic Growth Hormone Producing Pituitary Adenoma with a High Ki-67 Labeling Index Peer-reviewed

Toshiki Endo, Yoshikazu Ogawa, Mika Watanabe, Teiji Tominaga

Journal of Neurological Surgery, Part A: Central European Neurosurgery　79　(1)　90-95　2018/01/01
Publisher: Georg Thieme Verlag
DOI： 10.1055/s-0037-1600515 　

ISSN： 2193-6323 2193-6315
Convection-enhanced delivery of sulfasalazine prolongs survival in a glioma stem cell brain tumor model. International-journal Peer-reviewed

Shinya Haryu, Ryuta Saito, Wenting Jia, Takuhiro Shoji, Yui Mano, Aya Sato, Masayuki Kanamori, Yukihiko Sonoda, Oltea Sampetrean, Hideyuki Saya, Teiji Tominaga

Journal of neuro-oncology　136　(1)　23-31　2018/01

DOI： 10.1007/s11060-017-2621-7 　

ISSN： 0167-594X

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Expression of CD44 in glioma cells was previously correlated with tumor grade and is considered a stem cell marker. CD44 stabilizes the cystine-glutamate transporter (xCT) and inhibits apoptosis in cancer stem cells (CSCs). Recently it was found that Sulfasalazine (SSZ), an anti-inflammatory drug, acts as an inhibitor of xCT and therefore has potential as a targeted therapy for CSCs. In this study, we tested an efficacy of SSZ against glioma stem cell model developed in rats. As poor penetration of blood-brain barrier resulted in insufficient efficacy of systemic SSZ treatment, SSZ was delivered locally with convection-enhanced delivery (CED). In vitro, expression of CD44 in glioma cells and efficacy of SSZ against glioma cells and glioma stem cells were confirmed. SSZ demonstrated anti-proliferative activity in a dose dependent manner against these cells. This activity was partially reversible with the addition of antioxidant, N-acetyl-L-cysteine, to the medium. In vivo, CED successfully delivered SSZ into the rat brain parenchyma. When delivered at 5 mM concentration, which was the highest possible concentration when SSZ was dissolved in water, CED of SSZ resulted in almost no tissue damage. Against highly malignant bRiTs-G3 brain tumor xenografted rat model; the glioma stem cell model, CED of SSZ at 5 mM concentration induced apoptosis and prolonged survival. Consequently, CED of SSZ induced glioma stem cell death without evidence of tissue damage to normal brain parenchyma. This strategy may be a promising targeted treatment against glioma stem cells.
Patient with Recurrent Anterior Cerebral Artery Dissecting Aneurysm After Stent-Assisted Coil Embolization Successfully Treated with A3-A3 Anastomosis Peer-reviewed

Yoshiharu Takahashi, Hidenori Endo, Toshiki Endo, Miki Fujimura, Kuniyasu Niizuma, Teiji Tominaga

World Neurosurgery　109　77-81　2018/01/01
Publisher: Elsevier Inc.
DOI： 10.1016/j.wneu.2017.09.128 　

ISSN： 1878-8769 1878-8750
Glioblastoma in neurofibromatosis 1 patients without IDH1, BRAF V600E, and TERT promoter mutations. Peer-reviewed

Ichiyo Shibahara, Yukihiko Sonoda, Hiroyoshi Suzuki, Akifumi Mayama, Masayuki Kanamori, Ryuta Saito, Yasuhiro Suzuki, Shoji Mashiyama, Hiroshi Uenohara, Mika Watanabe, Toshihiro Kumabe, Teiji Tominaga

Brain tumor pathology　35　(1)　10-18　2018/01

DOI： 10.1007/s10014-017-0302-z 　

ISSN： 1433-7398

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Pilocytic astrocytomas and low-grade gliomas are more common compared with glioblastomas in patients with neurofibromatosis 1 (NF1). A recent genome-wide analysis has shown frequent NF1 gene alterations in the mesenchymal subtype of a glioblastoma; however, little is known about clinicopathological features of glioblastomas in NF1 patients (NF1 glioblastomas). We analyzed four NF1 glioblastomas. Radiographical and intraoperative findings showed well-circumscribed tumors from surrounding brain. Pathological analysis presented a paucity of processes with an eosinophilic cytoplasm, bizarre nuclei, xanthomatous-like appearance, multinucleated giant cells, and histiocytoid appearance. During the follow-up period, one patient died at 49 months and others remained alive for 60, 87, and 106 months; thus, patients with NF1 glioblastoma presented a relatively favorable survival. None of the NF1 glioblastomas harbored isocitrate dehydrogenase 1 (IDH1) gene mutation, v-RAF murine sarcoma viral oncogene homolog B1 (BRAF) gene mutation, and telomerase reverse transcriptase (TERT) gene promoter mutation. We identified that NF1 glioblastoma is a unique subset of glioblastoma.
Traumatic midline subarachnoid hemorrhage on initial computed tomography as a marker of severe diffuse axonal injury. Peer-reviewed

Mata-Mbemba D, Mugikura S, Nakagawa A, Murata T, Ishii K, Kushimoto S, Tominaga T, Takahashi S, Takase K

Journal of neurosurgery　1-8　2018/01

DOI： 10.3171/2017.6.JNS17466 　

ISSN： 0022-3085
Minimally invasive surgical approach to filum lipoma Peer-reviewed

Toshiaki Hayashi, Tomomi Kimiwada, Misaki Kohama, Reizo Shirane, Teiji Tominaga

Neurologia Medico-Chirurgica　58　(3)　132-137　2018
Publisher: Japan Neurosurgical Society
DOI： 10.2176/nmc.oa.2017-0200 　

ISSN： 1349-8029 0470-8105
Fingolimod-associated PML with mild IRIS in MS: A clinicopathologic study. International-journal Peer-reviewed

Shuhei Nishiyama, Tatsuro Misu, Yukiko Shishido-Hara, Kazuo Nakamichi, Masayuki Saijo, Yoshiki Takai, Kentarou Takei, Naoki Yamamoto, Hiroshi Kuroda, Ryuta Saito, Mika Watanabe, Teiji Tominaga, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki

Neurology(R) neuroimmunology & neuroinflammation　5　(1)　e415　2018/01

DOI： 10.1212/NXI.0000000000000415 　

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Objective: To clarify the clinical, neuropathologic, and virologic characteristics of progressive multifocal leukoencephalopathy (PML) and its immune reconstitution inflammatory syndrome (IRIS) in a patient with fingolimod-treated MS. Methods: A case study. Results: A 34-year-old patient with MS using fingolimod for 4 years had a gradual progression of right hemiparesis and aphasia with a new subcortical white matter lesion in the precentral gyrus by initial MRI. Blood tests were normal, except for lymphopenia (160 cells/μL). One month after the cessation of fingolimod, brain MRI depicted a diffusely exacerbated hyperintensity on fluid-attenuated inversion recovery and diffusion-weighed imaging in the white matter with punctate gadolinium enhancement, suggesting PML-IRIS. A very low level of JC virus (JCV)-DNA (15 copies/mL) was detected in the CSF as judged by quantitative PCR. Brain tissues were biopsied from the left frontal lesion, which showed some small demyelinated foci with predominant loss of myelin-associated glycoprotein with infiltrations of lymphocytes and macrophages, but clear viral inclusion was not observed with hematoxylin-eosin staining. JCV-DNA was uniquely detectable in an active inflammatory demyelinating lesion by in situ hybridization, possibly suggesting an early phase of PML. DNA extracted from the brain sample was positive for JCV-DNA (151 copies/cell). It took 3 months to normalize the blood lymphocyte count. The patient was treated with 1 g of IV methylprednisolone for 3 days and a weekly oral dose (375 mg) of mefloquine, and her symptoms gradually improved. Conclusion: Low CSF JCV-DNA and unfound viral inclusions initially made her diagnosis difficult. The clinical course of fingolimod-associated PML may be associated with mild immune reconstitution.
Successful presurgical endovascular management of venous sinus thrombosis associated with high-grade cerebral arteriovenous malformation: A case report Peer-reviewed

Yoshinari Osada, Hidenori Endo, Kenichi Sato, Yasushi Matsumoto, Toshiki Endo, Miki Fujimura, Teiji Tominaga

Interventional Neuroradiology　23　(6)　656-660　2017/12/01
Publisher: SAGE Publications Inc.
DOI： 10.1177/1591019917728255 　

ISSN： 1591-0199
Bath plug closure method for cerebrospinal fluid leakage by endoscopic endonasal approach cooperative treatment by neurosurgeons and otolaryngologists Peer-reviewed

Tomohiro Kawaguchi, Kazuya Arakawa, Kazuhiro Nomura, Yoshikazu Ogawa, Yukio Katori, Teiji Tominaga

Neurological Surgery　45　(12)　1067-1073　2017/12/01
Publisher: Igaku-Shoin Ltd
DOI： 10.11477/mf.1436203648 　

ISSN： 1882-1251 0301-2603
Revascularization of the anterior cerebral artery by Y-shaped superficial temporal artery interposition graft for the treatment of a de novo aneurysm arising at the site of A₃-A₃ bypass: technical case report. Peer-reviewed

Endo H, Sugiyama SI, Endo T, Fujimura M, Shimizu H, Tominaga T

Journal of neurosurgery　1-5　2017/12

DOI： 10.3171/2017.6.JNS17931 　

ISSN： 0022-3085
Predicting Tissue Breaking Strengths in the Epileptic Brain with T2 Relaxometry: Application of Pulsed Water Jet Dissection System for Epilepsy Surgery Peer-reviewed

Yoko Takahashi, Masaki Iwasaki, Atsuhiro Nakagawa, Shiho Sato, Nobukazu Nakasato, Teiji Tominaga

JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY　78　(6)　561-565　2017/11

DOI： 10.1055/s-0036-1593959 　

ISSN： 2193-6315

eISSN： 2193-6323
Ruptured Vertebral Artery Dissecting Aneurysm Concurrent with Spontaneous Cervical Internal Carotid Artery Dissection: A Report of Three Cases and Literature Review Peer-reviewed

Yosuke Akamatsu, Kenichi Sato, Hidenori Endo, Yasushi Matsumoto, Teiji Tominaga

WORLD NEUROSURGERY　107　1048.e1-1048.e6　2017/11

DOI： 10.1016/j.wneu.2017.08.016 　

ISSN： 1878-8750

eISSN： 1878-8769
Recovery from diabetes insipidus and preservation of thyroid function after craniopharyngioma removal and pituitary stalk sectioning Peer-reviewed

Yoshikazu Ogawa, Kuniyasu Niizuma, Teiji Tominaga

CLINICAL NEUROLOGY AND NEUROSURGERY　162　36-40　2017/11

DOI： 10.1016/j.clineuro.2017.09.005 　

ISSN： 0303-8467

eISSN： 1872-6968
Intra-operative hemorrhage due to hyperperfusion during direct revascularization surgery in an adult patient with moyamoya disease: a case report Peer-reviewed

Hiroki Uchida, Hidenori Endo, Miki Fujimura, Toshiki Endo, Kuniyasu Niizuma, Teiji Tominaga

NEUROSURGICAL REVIEW　40　(4)　679-684　2017/10

DOI： 10.1007/s10143-017-0868-2 　

ISSN： 0344-5607

eISSN： 1437-2320
An investigation into the effects and prognostic factors of cognitive decline following subthalamic nucleus stimulation in patients with Parkinson's disease Peer-reviewed

Taro Nimura, Ken-ichi Nagamatsu, Tadashi Ando, Arifumi Matsumoto, Kinya Hisanaga, Teiji Tominaga

JOURNAL OF CLINICAL NEUROSCIENCE　44　164-168　2017/10

DOI： 10.1016/j.jocn.2017.06.018 　

ISSN： 0967-5868

eISSN： 1532-2653
[Current Status of Epilepsy Surgery in Adults]. Peer-reviewed

Shin-Ichiro Osawa, Masaki Iwasaki, Teiji Tominaga

Brain and nerve = Shinkei kenkyu no shinpo　69　(10)　1105-1113　2017/10

DOI： 10.11477/mf.1416200878 　

ISSN： 1881-6096

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Epilepsy surgery is an effective way to control seizures in patients with refractory epilepsy, even in patients in whom drug therapy has not resulted in adequate seizure control. Many studies support the efficacy and safety of resective and non-resective surgeries for the treatment of refractory epilepsy in appropriately selected individuals. However, it is sometimes argued that epilepsy surgery is underutilized despite the evidence and guidelines supporting its use. Among the causes cited for underutilization of this treatment are numerous barriers to epilepsy surgery. Further strategies are needed to increase access to surgery and to improve communication about the effectiveness of this potentially life-changing procedure. In addition, epilepsy surgery is only one part of the multimodal treatment of refractory epilepsy. A comprehensive approach is required to address the medical, surgical, psychosocial, rehabilitation and moral needs of patients with epilepsy in order to improve their quality of life.
Efficacy of Early Surgery for Neurological Improvement in Spinal Cord Injury without Radiographic Evidence of Trauma in the Elderly Peer-reviewed

Tomoo Inoue, Shinsuke Suzuki, Toshiki Endo, Hiroshi Uenohara, Teiji Tominaga

WORLD NEUROSURGERY　105　790-795　2017/09

DOI： 10.1016/j.wneu.2017.06.070 　

ISSN： 1878-8750

eISSN： 1878-8769
Temporal and Spatial Changes in Cerebral Blood Flow during Management for Preventing Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage: Serial Semiquantitative Analysis Peer-reviewed

Kenichi Sato, Hiroaki Shimizu, Takashi Inoue, Miki Fujimura, Hidenori Endo, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　26　(9)　2027-2037　2017/09

DOI： 10.1016/j.jstrokecerebrovasdis.2017.06.006 　

ISSN： 1052-3057

eISSN： 1532-8511
Transient Global Cerebral Ischemia Induces RNF213, a Moyamoya Disease Susceptibility Gene, in Vulnerable Neurons of the Rat Hippocampus CA1 Subregion and Ischemic Cortex Peer-reviewed

Mika Sato-Maeda, Miki Fujimura, Sherif Rashad, Yuiko Morita-Fujimura, Kuniyasu Niizuma, Hiroyuki Sakata, Shuntaro Ikawa, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　26　(9)　1904-1911　2017/09

DOI： 10.1016/j.jstrokecerebrovasdis.2017.06.032 　

ISSN： 1052-3057

eISSN： 1532-8511
Factors contributing to surgical intervention for subacute subdural hematoma enlargement in patients with mild head injuries Peer-reviewed

Yosuke Akamatsu, Tohru Sasaki, Masayuki Kanamori, Shinsuke Suzuki, Hiroshi Uenohara, Teiji Tominaga

Neurological Surgery　45　(9)　771-779　2017/09/01
Publisher: Igaku-Shoin Ltd
DOI： 10.11477/mf.1436203591 　

ISSN： 1882-1251 0301-2603
Endovascular Treatment for carotid blowout syndrome after radiation for esophageal cancer: A case report Peer-reviewed

Shigefumi Takahashi, Tomohiro Kawaguchi, Kuniyasu Nhzuma, Atsuhiro Nakagawa, Miki Fujimura, Takenori Ogawa, Yukio Katori, Teiji Tominaga

Neurological Surgery　45　(9)　791-798　2017/09/01
Publisher: Igaku-Shoin Ltd
DOI： 10.11477/mf.1436203594 　

ISSN： 1882-1251 0301-2603

eISSN： 1882-1251
The Piezo Actuator-Driven Pulsed Water Jet System for Minimizing Renal Damage after Off-Clamp Laparoscopic Partial Nephrectomy Peer-reviewed

Yoshihiro Kamiyama, Shinichi Yamashita, Atsuhiro Nakagawa, Shinji Fujii, Koji Mitsuzuka, Yasuhiro Kaiho, Akihiro Ito, Takaaki Abe, Teiji Tominaga, Yoichi Arai

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　243　(1)　57-65　2017/09

DOI： 10.1620/tjem.243.57 　

ISSN： 0040-8727

eISSN： 1349-3329
Single-Session Hematoma Removal and Transcranial Coil Embolization for a Cavernous Sinus Dural Arteriovenous Fistula: A Technical Case Report Peer-reviewed

Yosuke Akamatsu, Kenichi Sato, Hidenori Endo, Yasushi Matsumoto, Teiji Tominaga

WORLD NEUROSURGERY　104　1046.e7-1046.e12　2017/08

DOI： 10.1016/j.wneu.2017.04.009 　

ISSN： 1878-8750

eISSN： 1878-8769
Opening the ventricle during surgery diminishes survival among patients with newly diagnosed glioblastoma treated with carmustine wafers: a multi-center retrospective study Peer-reviewed

Yukihiko Sonoda, Ichiyo Shibahara, Ken-ichiro Matsuda, Ryuta Saito, Tomoyuki Kawataki, Masaya Oda, Yuichi Sato, Hirokazu Sadahiro, Sadahiro Nomura, Toshio Sasajima, Takaaki Beppu, Masayuki Kanamori, Kaori Sakurada, Toshihiro Kumabe, Teiji Tominaga, Hiroyuki Kinouchi, Hiroaki Shimizu, Kuniaki Ogasawara, Michiyasu Suzuki

JOURNAL OF NEURO-ONCOLOGY　134　(1)　83-88　2017/08

DOI： 10.1007/s11060-017-2488-7 　

ISSN： 0167-594X

eISSN： 1573-7373
Clinical Characteristics and Outcome in Elderly Patients with Traumatic Brain Injury: For Establishment of Management Strategy Peer-reviewed

Hiroshi Karibe, Toshiaki Hayashi, Ayumi Narisawa, Motonobu Kameyama, Atsuhiro Nakagawa, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　57　(8)　418-425　2017/08

DOI： 10.2176/nmc.st.2017-0058 　

ISSN： 0470-8105

eISSN： 1349-8029
Endoscopic third ventriculostomy for hydrocephalus in a patient with Klippel-Feil syndrome: a case report. International-journal Peer-reviewed

Ishida T, Inoue T, Fujimura M, Shimoda Y, Ezura M, Uenohara H, Tominaga T

Clinical case reports　5　(8)　1344-1347　2017/08

DOI： 10.1002/ccr3.1063 　

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A patient with Klippel-Feil syndrome presented with hydrocephalus secondary to intraventricular hemorrhage. Fusion of the cervical vertebrae may have impeded cerebrospinal fluid flow. Change in the properties of cerebrospinal fluid flow after hemorrhage may have induced noncommunicating hydrocephalus. Endoscopic third ventriculostomy was effective for the treatment of hydrocephalus associated with Klippel-Feil syndrome.
Subarachnoid small vein occlusion due to inflammatory fibrosis-a possible mechanism for cerebellar infarction in cryptococcal meningoencephalitis: a case report Peer-reviewed

Yoshiteru Shimoda, Satoru Ohtomo, Hiroaki Arai, Takashi Ohtoh, Teiji Tominaga

BMC NEUROLOGY　17　(1)　157　2017/08

DOI： 10.1186/s12883-017-0934-y 　

ISSN： 1471-2377
Distant recurrences limit the survival of patients with thalamic high-grade gliomas after successful resection Peer-reviewed

Ryuta Saito, Toshihiro Kumabe, Masayuki Kanamori, Yukihiko Sonoda, Teiji Tominaga

NEUROSURGICAL REVIEW　40　(3)　469-477　2017/07

DOI： 10.1007/s10143-016-0804-x 　

ISSN： 0344-5607

eISSN： 1437-2320
Application of actuator-driven pulsed water jet in aneurysmal subarachnoid hemorrhage surgery: its effectiveness for dissection around ruptured aneurysmal walls and subarachnoid clot removal Peer-reviewed

Hidenori Endo, Toshiki Endo, Atsuhiro Nakagawa, Miki Fujimura, Teiji Tominaga

NEUROSURGICAL REVIEW　40　(3)　485-493　2017/07

DOI： 10.1007/s10143-016-0809-5 　

ISSN： 0344-5607

eISSN： 1437-2320
Rapid Deterioration of Latent HBV Hepatitis during Cushing Disease and Posttraumatic Stress Disorder after Earthquake Peer-reviewed

Ryosuke Tashiro, Yoshikazu Ogawa, Teiji Tominaga

JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY　78　(4)　407-411　2017/07

DOI： 10.1055/s-0037-1598052 　

ISSN： 2193-6315

eISSN： 2193-6323
Uneven cerebral hemodynamic change as a cause of neurological deterioration in the acute stage after direct revascularization for moyamoya disease: cerebral hyperperfusion and remote ischemia caused by the 'watershed shift' Peer-reviewed

Xian-kun Tu, Miki Fujimura, Sherif Rashad, Shunji Mugikura, Hiroyuki Sakata, Kuniyasu Niizuma, Teiji Tominaga

NEUROSURGICAL REVIEW　40　(3)　507-512　2017/07

DOI： 10.1007/s10143-017-0845-9 　

ISSN： 0344-5607

eISSN： 1437-2320
Navigation-guided clipping of a de novo aneurysm associated with superficial temporal artery-middle cerebral artery bypass combined with indirect pial synangiosis in a patient with moyamoya disease Peer-reviewed

Daiki Aburakawa, Miki Fujimura, Kuniyasu Niizuma, Hiroyuki Sakata, Hidenori Endo, Teiji Tominaga

NEUROSURGICAL REVIEW　40　(3)　517-521　2017/07

DOI： 10.1007/s10143-017-0866-4 　

ISSN： 0344-5607

eISSN： 1437-2320
A hemorrhagic complication after Onyx embolization of a tentorial dural arteriovenous fistula: A caution about subdural extension with pial arterial supply Peer-reviewed

Kenichi Sato, Yasushi Matsumoto, Hidenori Endo, Teiji Tominaga

INTERVENTIONAL NEURORADIOLOGY　23　(3)　307-312　2017/06

DOI： 10.1177/1591019917694839 　

ISSN： 1591-0199

eISSN： 2385-2011
Suprasellar Hemangioblastoma Unrelated to von Hippel-Lindau Disease Successfully Treated through Extended Transsphenoidal Approach: Diagnostic Value of Von Hippel-Lindau Disease Gene-Derived Protein Peer-reviewed

Jia Wenting, Yoshikazu Ogawa, Jun Ito, Teiji Tominaga

JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY　78　(3)　296-301　2017/05

DOI： 10.1055/s-0036-1582016 　

ISSN： 2193-6315

eISSN： 2193-6323
Fine morphological evaluation of hypothalamus in patients with hyperphagia Peer-reviewed

Yoshikazu Ogawa, Kuniyasu Niizuma, Teiji Tominaga

ACTA NEUROCHIRURGICA　159　(5)　865-871　2017/05

DOI： 10.1007/s00701-017-3112-5 　

ISSN： 0001-6268

eISSN： 0942-0940
Intraoperative Visualization of Subependymal Arteries at the Atrium Supplying the Descending Motor Pathway Peer-reviewed

Mitsuto Hanihara, Sumito Sato, Ichiyo Shibahara, Ryuta Saito, Masayuki Kanamori, Yukihiko Sonoda, Hiroyuki Kinouchi, Teiji Tominaga, Toshihiro Kumabe

WORLD NEUROSURGERY　101　296-303　2017/05

DOI： 10.1016/j.wneu.2017.02.022 　

ISSN： 1878-8750

eISSN： 1878-8769
Convection-enhanced delivery of a hydrophilic nitrosourea ameliorates deficits and suppresses tumor growth in experimental spinal cord glioma models Peer-reviewed

Shogo Ogita, Toshiki Endo, Shinichiro Sugiyama, Ryuta Saito, Tomoo Inoue, Akira Sumiyoshi, Hiroi Nonaka, Ryuta Kawashima, Yukihiko Sonoda, Teiji Tominaga

ACTA NEUROCHIRURGICA　159　(5)　939-946　2017/05

DOI： 10.1007/s00701-017-3123-2 　

ISSN： 0001-6268

eISSN： 0942-0940
Use of Indocyanine Green Fluorescence Endoscopy to Treat Concurrent Perimedullary and Dural Arteriovenous Fistulas in the Cervical Spine Peer-reviewed

Akira Ito, Toshiki Endo, Tomoo Inoue, Hidenori Endo, Kenichi Sato, Teiji Tominaga

WORLD NEUROSURGERY　101　814.e1-814.e6　2017/05

DOI： 10.1016/j.wneu.2017.03.032 　

ISSN： 1878-8750

eISSN： 1878-8769
Embolization of the choroidal artery in the treatment of cerebral arteriovenous malformations Peer-reviewed

Alaa Elkordy, Hidenori Endo, Kenichi Sato, Yasushi Matsumoto, Ryushi Kondo, Kuniyasu Niizuma, Toshiki Endo, Miki Fujimura, Teiji Tominaga

JOURNAL OF NEUROSURGERY　126　(4)　1114-1122　2017/04

DOI： 10.3171/2016.2.JNS152370 　

ISSN： 0022-3085

eISSN： 1933-0693
Stereotactic radiosurgery as a feasible treatment for intramedullary spinal arteriovenous malformations: a single-center observation Peer-reviewed

Sherif Rashad, Toshiki Endo, Yoshihiro Ogawa, Kenichi Sato, Hidenori Endo, Yasushi Matsumoto, Akira Takahashi, Teiji Tominaga

NEUROSURGICAL REVIEW　40　(2)　259-266　2017/04

DOI： 10.1007/s10143-016-0758-z 　

ISSN： 0344-5607

eISSN： 1437-2320
Fourth Ventricle Outlet Obstruction with Expanding Space on the Surface of Cerebellum Peer-reviewed

Yoshiteru Shimoda, Kensuke Murakami, Norio Narita, Teiji Tominaga

WORLD NEUROSURGERY　100　711.e1-711.e5　2017/04

DOI： 10.1016/j.wneu.2017.01.088 　

ISSN： 1878-8750

eISSN： 1878-8769
New Application of Actuator-Driven Pulsed Water Jet for Spinal Cord Dissection: An Experimental Study in Pigs Peer-reviewed

Toshiki Endo, Jia Wenting, Atsuhiro Nakagawa, Hidenori Endo, Yuto Sagae, Masaki Iwasaki, Teiji Tominaga

JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY　78　(2)　137-143　2017/03

DOI： 10.1055/s-0036-1584919 　

ISSN： 2193-6315

eISSN： 2193-6323
Genome-wide methylation profiles in primary intracranial germ cell tumors indicate a primordial germ cell origin for germinomas Peer-reviewed

Shintaro Fukushima, Satoshi Yamashita, Hisato Kobayashi, Hirokazu Takami, Kohei Fukuoka, Taishi Nakamura, Kai Yamasaki, Yuko Matsushita, Hiromi Nakamura, Yasushi Totoki, Mamoru Kato, Tomonari Suzuki, Kazuhiko Mishima, Takaaki Yanagisawa, Akitake Mukasa, Nobuhito Saito, Masayuki Kanamori, Toshihiro Kumabe, Teiji Tominaga, Motoo Nagane, Toshihiko Iuchi, Koji Yoshimoto, Masahiro Mizoguchi, Kaoru Tamura, Keiichi Sakai, Kazuhiko Sugiyama, Mitsutoshi Nakada, Kiyotaka Yokogami, Hideo Takeshima, Yonehiro Kanemura, Masahide Matsuda, Akira Matsumura, Kazuhiko Kurozumi, Keisuke Ueki, Masahiro Nonaka, Akio Asai, Nobutaka Kawahara, Yuichi Hirose, Tatusya Takayama, Yoichi Nakazato, Yoshitaka Narita, Tatsuhiro Shibata, Masao Matsutani, Toshikazu Ushijima, Ryo Nishikawa, Koichi Ichimura

ACTA NEUROPATHOLOGICA　133　(3)　445-462　2017/03

DOI： 10.1007/s00401-017-1673-2 　

ISSN： 0001-6322

eISSN： 1432-0533
Human Muse Cells Reconstruct Neuronal Circuitry in Subacute Lacunar Stroke Model Peer-reviewed

Hiroki Uchida, Kuniyasu Niizuma, Yoshihiro Kushida, Shohei Wakao, Teiji Tominaga, Cesario V. Borlongan, Mari Dezawa

STROKE　48　(2)　428-435　2017/02

DOI： 10.1161/STROKEAHA.116.014950 　

ISSN： 0039-2499

eISSN： 1524-4628
Response by Sugiyama and Tominaga to Letter Regarding Article, "Blood Flow Into Basilar Tip Aneurysms: A Predictor for Recanalization After Coil Embolization". Peer-reviewed

Sugiyama SI, Tominaga T

Stroke　48　(2)　e77　2017/02

DOI： 10.1161/STROKEAHA.116.016034 　

ISSN： 0039-2499
Preoperative embolization and immediate removal of a giant pituitary adenoma: A case report Peer-reviewed

Shunsuke Omodaka, Yoshikazu Ogawa, Kenichi Sato, Yasushi Matsumoto, Teiji Tominaga

BMC Research Notes　10　(1)　63　2017/01/26
Publisher: BioMed Central Ltd.
DOI： 10.1186/s13104-017-2383-5 　

ISSN： 1756-0500
De Novo Development of Moyamoya Disease in an Adult Female with a Genetic Variant of the RNF-213 Gene: Case Report Peer-reviewed

Ryosuke Tashiro, Miki Fujimura, Kuniyasu Niizuma, Hidenori Endo, Hiroyuki Sakata, Mika Sato-Maeda, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　26　(1)　E8-E11　2017/01

DOI： 10.1016/j.jstrokecerebrovasdis.2016.09.035 　

ISSN： 1052-3057

eISSN： 1532-8511
Extremely Late Recurrence 21 Years after Total Removal of Immature Teratoma: A Case Report and Literature Review Peer-reviewed

Yui Mano, Masayuki Kanamori, Toshihiro Kumabe, Ryuta Saito, Mika Watanabe, Yukihiko Sonoda, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　57　(1)　51-56　2017/01

DOI： 10.2176/nmc.cr.2016-0241 　

ISSN： 0470-8105

eISSN： 1349-8029
Convection-enhanced Delivery of Therapeutics for Malignant Gliomas Peer-reviewed

Ryuta Saito, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　57　(1)　8-16　2017/01

DOI： 10.2176/nmc.ra.2016-0071 　

ISSN： 0470-8105

eISSN： 1349-8029
Preventive Effect of Clazosentan against Cerebral Vasospasm after Clipping Surgery for Aneurysmal Subarachnoid Hemorrhage in Japanese and Korean Patients Peer-reviewed

Miki Fujimura, Jin-Yang Joo, Jong-Soo Kim, Motonori Hatta, Yoshinari Yokoyama, Teiji Tominaga

CEREBROVASCULAR DISEASES　44　(1-2)　59-67　2017

DOI： 10.1159/000475824 　

ISSN： 1015-9770

eISSN： 1421-9786
Satellite Sign: A Poor Outcome Predictor in Intracerebral Hemorrhage Peer-reviewed

Yoshiteru Shimoda, Satoru Ohtomo, Hiroaki Arai, Ken Okada, Teiji Tominaga

CEREBROVASCULAR DISEASES　44　(3-4)　105-112　2017

DOI： 10.1159/000477179 　

ISSN： 1015-9770

eISSN： 1421-9786
Traumatic Spinal Perimedullary Arteriovenous Fistula Induced by a Cervical Glass Stab Injury Peer-reviewed

Shogo Ogita, Toshiki Endo, Tomoo Inoue, Kenichi Sato, Hidenori Endo, Teiji Tominaga

WORLD NEUROSURGERY　96　610.e9-610.e13　2016/12

DOI： 10.1016/j.wneu.2016.09.024 　

ISSN： 1878-8750

eISSN： 1878-8769
Daughter Sac Formation Related to Blood Inflow Jet in an Intracranial Aneurysm Peer-reviewed

Sin-ichiro Sugiyama, Hidenori Endo, Shunsuke Omodaka, Toshiki Endo, Kuniyasu Niizuma, Sherif Rashad, Toshio Nakayama, Kenichi Funamoto, Makoto Ohta, Teiji Tominaga

WORLD NEUROSURGERY　96　396-402　2016/12

DOI： 10.1016/j.wneu.2016.09.040 　

ISSN： 1878-8750

eISSN： 1878-8769
Impaired Collateral Flow Compensation During Chronic Cerebral Hypoperfusion in the Type 2 Diabetic Mice Peer-reviewed

Yasuo Nishijima, Yosuke Akamatsu, Shih Yen Yang, Chih Cheng Lee, Utku Baran, Shaozhen Song, Ruikang K. Wang, Teiji Tominaga, Jialing Liu

STROKE　47　(12)　3014-3021　2016/12

DOI： 10.1161/STROKEAHA.116.014882 　

ISSN： 0039-2499

eISSN： 1524-4628
Convection-enhanced delivery of SN-38-loaded polymeric micelles (NK012) enables consistent distribution of SN-38 and is effective against rodent intracranial brain tumor models Peer-reviewed

Rong Zhang, Ryuta Saito, Yui Mano, Akira Sumiyoshi, Masayuki Kanamori, Yukihiko Sonoda, Ryuta Kawashima, Teiji Tominaga

DRUG DELIVERY　23　(8)　2780-2786　2016/10

DOI： 10.3109/10717544.2015.1081994 　

ISSN： 1071-7544

eISSN： 1521-0464
Long-term follow-up of pediatric moyamoya disease treated by combined direct-indirect revascularization surgery: single institute experience with surgical and perioperative management. Peer-reviewed

Rashad S, Fujimura M, Niizuma K, Endo H, Tominaga T

Neurosurgical review　39　(4)　615-623　2016/10

DOI： 10.1007/s10143-016-0734-7 　

ISSN： 0344-5607
Sarcoma-like tumor originating from oligodendroglioma Peer-reviewed

Takuhiro Shoji, Ryuta Saito, Masayuki Kanamori, Yukihiko Sonoda, Mika Watanabe, Teiji Tominaga

BRAIN TUMOR PATHOLOGY　33　(4)　255-260　2016/10

DOI： 10.1007/s10014-016-0268-2 　

ISSN： 1433-7398

eISSN： 1861-387X
T2 relaxometry improves detection of non-sclerotic epileptogenic hippocampus Peer-reviewed

Shiho Sato, Masaki Iwasaki, Hiroyoshi Suzuki, Shunji Mugikura, Kazutaka Jin, Teiji Tominaga, Kei Takase, Shoki Takahashi, Nobukazu Nakasato

EPILEPSY RESEARCH　126　1-9　2016/10

DOI： 10.1016/j.eplepsyres.2016.06.001 　

ISSN： 0920-1211

eISSN： 1872-6844
Development of Abnormal Hemispheric Vascular Networks Mimicking Cerebral Proliferative Angiopathy in a Child Originally Diagnosed with Deep-Seated Arteriovenous Fistula Peer-reviewed

Hiroyuki Sakata, Miki Fujimura, Kenichi Sato, Kuniyasu Niizuma, Hidenori Endo, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　25　(10)　E200-E204　2016/10

DOI： 10.1016/j.jstrokecerebrovasdis.2016.07.042 　

ISSN： 1052-3057

eISSN： 1532-8511
Blood Flow Into Basilar Tip Aneurysms: A Predictor for Recanalization After Coil Embolization Peer-reviewed

Shin-ichiro Sugiyama, Kuniyasu Niizuma, Kenichi Sato, Sherif Rashad, Misaki Kohama, Hidenori Endo, Toshiki Endo, Yasushi Matsumoto, Makoto Ohta, Teiji Tominaga

STROKE　47　(10)　2541-2547　2016/10

DOI： 10.1161/STROKEAHA.116.013555 　

ISSN： 0039-2499

eISSN： 1524-4628
A case of thrombectomy to treat acute occlusion of the vertebral artery due to a fracture of the lateral mass of the first cervical vertebra Peer-reviewed

Michiko Yokosawa, Masahiro Yoshida, Masaki Mino, Naoko Yamashita, Teiji Tominaga

Neurological Surgery　44　(10)　875-880　2016/10/01
Publisher: Igaku-Shoin Ltd
DOI： 10.11477/mf.1436203394 　

ISSN： 1882-1251 0301-2603
Sturge-Weber syndrome with intracerebral hemorrhage: a case report Peer-reviewed

Masashi Chonan, Yasuhiro Suzuki, Shinya Haryu, Shoji Mashiyama, Teiji Tominaga

SPRINGERPLUS　5　(1)　1746　2016/10

DOI： 10.1186/s40064-016-3439-z 　

ISSN： 2193-1801
The Tohoku Medical Megabank Project: Design and Mission Peer-reviewed

Shinichi Kuriyama, Nobuo Yaegashi, Fuji Nagami, Tomohiko Arai, Yoshio Kawaguchi, Noriko Osumi, Masaki Sakaida, Yoichi Suzuki, Keiko Nakayama, Hiroaki Hashizume, Gen Tamiya, Hiroshi Kawame, Kichiya Suzuki, Atsushi Hozawa, Naoki Nakaya, Masahiro Kikuya, Hirohito Metoki, Ichiro Tsuji, Nobuo Fuse, Hideyasu Kiyomoto, Junichi Sugawara, Akito Tsuboi, Shinichi Egawa, Kiyoshi Ito, Koichi Chida, Tadashi Ishii, Hiroaki Tomita, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Seizo Koshiba, Kengo Kinoshita, Soichi Ogishima, Takako Takai-Igarashi, Teiji Tominaga, Osamu Tanabe, Noriaki Ohuchi, Toru Shimosegawa, Shigeo Kure, Hiroshi Tanaka, Sadayoshi Ito, Jiro Hitomi, Kozo Tanno, Motoyuki Nakamura, Kuniaki Ogasawara, Seiichiro Kobayashi, Kiyomi Sakata, Mamoru Satoh, Atsushi Shimizu, Makoto Sasaki, Ryujin Endo, Kenji Sobue, Masayuki Yamamoto

JOURNAL OF EPIDEMIOLOGY　26　(9)　493-511　2016/09

DOI： 10.2188/jea.JE20150268 　

ISSN： 0917-5040
Impact of gross total resection in patients with WHO grade III glioma harboring the IDH 1/2 mutation without the 1p/19q co-deletion Peer-reviewed

Tomohiro Kawaguchi, Yukihiko Sonoda, Ichiyo Shibahara, Ryuta Saito, Masayuki Kanamori, Toshihiro Kumabe, Teiji Tominaga

JOURNAL OF NEURO-ONCOLOGY　129　(3)　505-514　2016/09

DOI： 10.1007/s11060-016-2201-2 　

ISSN： 0167-594X

eISSN： 1573-7373
Ischemic pituitary adenoma apoplexy-Clinical appearance and prognosis after surgical intervention Peer-reviewed

Yoshikazu Ogawa, Kuniyasu Niizuma, Shunji Mugikura, Teiji Tominaga

CLINICAL NEUROLOGY AND NEUROSURGERY　148　142-146　2016/09

DOI： 10.1016/j.clineuro.2016.07.013 　

ISSN： 0303-8467

eISSN： 1872-6968
A study of prognostic factors in 45 cases of atypical meningioma Peer-reviewed

Toshiki Endo, Ayumi Narisawa, Hosam Shata Mohamed Ali, Kensuke Murakami, Takashi Watanabe, Mika Watanabe, Hidefumi Jokura, Hidenori Endo, Miki Fujimura, Yukihiko Sonoda, Teiji Tominaga

ACTA NEUROCHIRURGICA　158　(9)　1661-1667　2016/09

DOI： 10.1007/s00701-016-2900-7 　

ISSN： 0001-6268

eISSN： 0942-0940
A case of hydrocephalus in listeria meningitis treated by endoscopic third ventriculostomy Peer-reviewed

Takatsugu Abe, Tomohiro Kawaguchi, Miki Fujimura, Teiji Tominaga

Neurological Surgery　44　(9)　761-766　2016/09/01
Publisher: Igaku-Shoin Ltd
DOI： 10.11477/mf.1436203373 　

ISSN： 1882-1251 0301-2603
Local convection-enhanced delivery of an anti-CD40 agonistic monoclonal antibody induces antitumor effects in mouse glioma models Peer-reviewed

Takuhiro Shoji, Ryuta Saito, Masashi Chonan, Ichiyo Shibahara, Aya Sato, Masayuki Kanamori, Yukihiko Sonoda, Toru Kondo, Naoto Ishii, Teiji Tominaga

NEURO-ONCOLOGY　18　(8)　1120-1128　2016/08

DOI： 10.1093/neuonc/now023 　

ISSN： 1522-8517

eISSN： 1523-5866
Temporal profile of magnetic resonance angiography and decreased ratio of regulatory T cells after immunological adjuvant administration to mice lacking RNF213, a susceptibility gene for moyamoya disease Peer-reviewed

Atsushi Kanoke, Miki Fujimur, Kuniyasu Niizuma, Taku Fujimura, Aya Kakizaki, Akira Ito, Hiroyuki Sakata, Mika Sato-Maeda, Shigeo Kure, Teiji Tominaga

BRAIN RESEARCH　1642　1-9　2016/07

DOI： 10.1016/j.brainres.2016.03.009 　

ISSN： 0006-8993

eISSN： 1872-6240
Central Retinal Artery Occlusion after the Endovascular Treatment of Unruptured Ophthalmic Artery Aneurysm: A Case Report and a Literature Review. Peer-reviewed

Elkordy AM, Sato K, Inoue Y, Mano Y, Matsumoto Y, Takahashi A, Tominaga T

NMC case report journal　3　(3)　71-74　2016/07
Publisher: The Japan Neurosurgical Society
DOI： 10.2176/nmccrj.cr.2015-0243 　

ISSN： 2188-4226

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Endovascular coil embolization for ophthalmic artery (OphA) aneurysms has a risk of occlusion of the OphA, which can lead to loss of vision. The authors report a patient with unruptured OphA aneurysm which treated with endovascular coiling and were complicated by blindness due to OphA thromboembolic occlusion after the procedure. The OphA successfully recanalized using local intra-arterial fibrinolysis with complete regain of visual acuity. The risk of visual loss due to thromboembolic complications cannot be ignored during endovascular coiling of the OphA aneurysm despite of good retrograde flow during OphA occlusion test using a balloon catheter. Rapid intervention is required for recovering visual disturbance in such a situation.
Recurrent neomorphic mutations of MTOR in central nervous system and testicular germ cell tumors may be targeted for therapy Peer-reviewed

Koichi Ichimura, Shintaro Fukushima, Yasushi Totoki, Yuko Matsushita, Ayaka Otsuka, Arata Tomiyama, Tohru Niwa, Hirokazu Takami, Taishi Nakamura, Tomonari Suzuki, Kohei Fukuoka, Takaaki Yanagisawa, Kazuhiko Mishima, Yoichi Nakazato, Fumie Hosoda, Yoshitaka Narita, Soichiro Shibui, Akihiko Yoshida, Akitake Mukasa, Nobuhito Saito, Toshihiro Kumabe, Masayuki Kanamori, Teiji Tominaga, Keiichi Kobayashi, Saki Shimizu, Motoo Nagane, Toshihiko Iuchi, Masahiro Mizoguchi, Koji Yoshimoto, Kaoru Tamura, Taketoshi Maehara, Kazuhiko Sugiyama, Mitsutoshi Nakada, Keiichi Sakai, Yonehiro Kanemura, Masahiro Nonaka, Akio Asai, Kiyotaka Yokogami, Hideo Takeshima, Nobutaka Kawahara, Tatsuya Takayama, Masahiro Yao, Mamoru Kato, Hiromi Nakamura, Natsuko Hama, Ryuichi Sakai, Toshikazu Ushijima, Masao Matsutani, Tatsuhiro Shibata, Ryo Nishikawa

ACTA NEUROPATHOLOGICA　131　(6)　889-901　2016/06

DOI： 10.1007/s00401-016-1557-x 　

ISSN： 0001-6322

eISSN： 1432-0533
Brain Stem Infarction Due to Basilar Artery Dissection in a Patient with Moyamoya Disease Four Years after Successful Bilateral Revascularization Surgeries Peer-reviewed

Takatsugu Abe, Miki Fujimura, Shunji Mugikura, Hidenori Endo, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　25　(6)　E79-E82　2016/06

DOI： 10.1016/j.jstrokecerebrovasdis.2016.03.024 　

ISSN： 1052-3057

eISSN： 1532-8511
Nonaneurysmal Subarachnoid Hemorrhage Due to Unfused or Twiglike Middle Cerebral Artery Rupture: Two Case Reports Peer-reviewed

Ryosuke Tashiro, Takashi Inoue, Ichiyo Shibahara, Masayuki Ezura, Hiroshi Uenohara, Miki Fujimura, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　25　(6)　E77-E78　2016/06

DOI： 10.1016/j.jstrokecerebrovasdis.2016.03.029 　

ISSN： 1052-3057

eISSN： 1532-8511
Intraparenchymal ultrasound application and improved distribution of infusate with convection-enhanced delivery in rodent and nonhuman primate brain Peer-reviewed

Yui Mano, Ryuta Saito, Yoichi Haga, Tadao Matsunaga, Rong Zhang, Masashi Chonan, Shinya Haryu, Takuhiro Shoji, Aya Sato, Yukihiko Sonoda, Noriko Tsuruoka, Keisuke Nishiyachi, Akira Sumiyoshi, Hiroi Nonaka, Ryuta Kawashima, Teiji Tominaga

JOURNAL OF NEUROSURGERY　124　(5)　1490-1500　2016/05

DOI： 10.3171/2015.3.JNS142152 　

ISSN： 0022-3085

eISSN： 1933-0693
Clinical features of subarachnoid hemorrhage in patients with positive cancer history Peer-reviewed

Ichiyo Shibahara, Takashi Watanabe, Masayuki Ezura, Takashi Inoue, Miki Fujimura, Naoto Kimura, Tomoo Inoue, Ichiro Suzuki, Akiko Nishino, Shinjitsu Nishimura, Hiroshi Uenohara, Teiji Tominaga

JOURNAL OF NEURO-ONCOLOGY　128　(1)　129-136　2016/05

DOI： 10.1007/s11060-016-2085-1 　

ISSN： 0167-594X

eISSN： 1573-7373
Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis Peer-reviewed

Eric M. Thompson, Thomas Hielscher, Eric Bouffet, Marc Remke, Betty Luu, Sridharan Gururangan, Roger E. McLendon, Darell D. Bigner, Eric S. Lipp, Sebastien Perreault, Yoon-Jae Cho, Gerald Grant, Seung-Ki Kim, Ji Yeoun Lee, Amulya A. Nageswara Rao, Caterina Giannini, Kay Ka Wai Li, Ho-Keung Ng, Yu Yao, Toshihiro Kumabe, Teiji Tominaga, Wieslawa A. Grajkowska, Marta Perek-Polnik, David C. Y. Low, Wan Tew Seow, Kenneth T. E. Chang, Jaume Mora, Ian F. Pollack, Ronald L. Hamilton, Sarah Leary, Andrew S. Moore, Wendy J. Ingram, Andrew R. Hallahan, Anne Jouvet, Michelle Fevre-Montange, Alexandre Vasiljevic, Cecile Faure-Conter, Tomoko Shofuda, Naoki Kagawa, Naoya Hashimoto, Nada Jabado, Alexander G. Weil, Tenzin Gayden, Takafumi Wataya, Tarek Shalaby, Michael Grotzer, Karel Zitterbart, Jaroslav Sterba, Leos Kren, Tibor Hortobagyi, Almos Klekner, Bognar Laszlo, Timea Pocza, Peter Hauser, Ulrich Schueller, Shin Jung, Woo-Youl Jang, Pim J. French, Johan M. Kros, Marie-Lise C. van Veelen, Luca Massimi, Jeffrey R. Leonard, Joshua B. Rubin, Rajeev Vibhakar, Lola B. Chambless, Michael K. Cooper, Reid C. Thompson, Claudia C. Faria, Alice Carvalho, Sofi Nunes, Jose Pimentel, Xing Fan, Karin M. Muraszko, Enrique Lopez-Aguilar, David Lyden, Livia Garzia, David J. H. Shih, Noriyuki Kijima, Christian Schneider, Jennifer Adamski, Paul A. Northcott, Marcel Kool, David T. W. Jones, Jennifer A. Chan, Ana Nikolic, Maria Luisa Garre, Erwin G. Van Meir, Satoru Osuka, Jeffrey J. Olson, Arman Jahangiri, Brandyn A. Castro, Nalin Gupta, William A. Weiss, Iska Moxon-Emre, Donald J. Mabbott, Alvaro Lassaletta, Cynthia E. Hawkins, Uri Tabori, James Drake, Abhaya Kulkarni, Peter Dirks, James T. Rutka, Andrey Korshunov, Stefan M. P. fister, Roger J. Packer, Vijay Ramaswamy, Michael D. Taylor

LANCET ONCOLOGY　17　(4)　484-495　2016/04

DOI： 10.1016/S1470-2045(15)00581-1 　

ISSN： 1470-2045

eISSN： 1474-5488
Peri-tumoral leakage during intra-tumoral convection-enhanced delivery has implications for efficacy of peri-tumoral infusion before removal of tumor Peer-reviewed

Xiaoliang Yang, Ryuta Saito, Taigen Nakamura, Rong Zhang, Yukihiko Sonoda, Toshihiro Kumabe, John Forsayeth, Krystof Bankiewicz, Teiji Tominaga

DRUG DELIVERY　23　(3)　781-786　2016/03

DOI： 10.3109/10717544.2014.914987 　

ISSN： 1071-7544

eISSN： 1521-0464
Ventricle wall dissection and vascular preservation with the pulsed water jet device: novel tissue dissector for flexible neuroendoscopic surgery Peer-reviewed

Tomohiro Kawaguchi, Atsuhiro Nakagawa, Toshiki Endo, Miki Fujimura, Yukihiko Sonoda, Teiji Tominaga

JOURNAL OF NEUROSURGERY　124　(3)　817-822　2016/03

DOI： 10.3171/2015.3.JNS142121 　

ISSN： 0022-3085

eISSN： 1933-0693
Noninvasive targeting delivery and in vivo magnetic resonance tracking method for live apoptotic cells in cerebral ischemia with functional Fe2O3 magnetic nanoparticles Peer-reviewed

Atsushi Saito, Moataz M. Mekawy, Akira Sumiyoshi, Jorge J. Riera, Hiroaki Shimizu, Ryuta Kawashima, Teiji Tominaga

JOURNAL OF NANOBIOTECHNOLOGY　14　19　2016/03

DOI： 10.1186/s12951-016-0173-1 　

ISSN： 1477-3155
Bone regeneration after chemotherapy for vault lymphoma Peer-reviewed

Yosuke Akamatsu, Masayuki Kanamori, Hiroshi Uenohara, Teiji Tominaga

BMJ Case Reports　2016　2016/02/22
Publisher: BMJ Publishing Group
DOI： 10.1136/bcr-2015-213524 　

ISSN： 1757-790X
Properties of convective delivery in spinal cord gray matter: laboratory investigation and computational simulations Peer-reviewed

Toshiki Endo, Yushi Fujii, Shin-ichiro Sugiyama, Rong Zhang, Shogo Ogita, Kenichi Funamoto, Ryuta Saito, Teiji Tominaga

JOURNAL OF NEUROSURGERY-SPINE　24　(2)　359-366　2016/02

DOI： 10.3171/2015.5.SPINE141148 　

ISSN： 1547-5654

eISSN： 1547-5646
Effects of Surgery and Antiplatelet Therapy in Ten-Year Follow-Up from the Registry Study of Research Committee on Moyamoya Disease in Japan Peer-reviewed

Satoshi Yamada, Koichi Oki, Yoshiaki Itoh, Satoshi Kuroda, Kiyohiro Houkin, Teiji Tominaga, Susumu Miyamoto, Nobuo Hashimoto, Norihiro Suzuki

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　25　(2)　340-349　2016/02

DOI： 10.1016/j.jstrokecerebrovasdis.2015.10.003 　

ISSN： 1052-3057

eISSN： 1532-8511
Canadian CT head rule and New Orleans Criteria in mild traumatic brain injury: comparison at a tertiary referral hospital in Japan Peer-reviewed

Daddy Mata-Mbemba, Shunji Mugikura, Atsuhiro Nakagawa, Takaki Murata, Yumiko Kato, Yasuko Tatewaki, Kei Takase, Shigeki Kushimoto, Teiji Tominaga, Shoki Takahashi

SPRINGERPLUS　5　176　2016/02

DOI： 10.1186/s40064-016-1781-9 　

ISSN： 2193-1801
Total regression of brain metastases in non-small cell lung cancer patients harboring EGFR mutations treated with gefitinib without radiotherapy: Two case reports Case Reports Peer-reviewed

Masashi Chonan, Norio Narita, Teiji Tominaga

BMC Research Notes　9　(1)　2　2016/01/02
Publisher: BioMed Central Ltd.
DOI： 10.1186/s13104-015-1834-0 　

ISSN： 1756-0500
Clinical profiles for seizure remission and developmental gains after total corpus callosotomy Peer-reviewed

Masaki Iwasaki, Mitsugu Uematsu, Naomi Hino-Fukuyo, Shin-ichiro Osawa, Yoshiteru Shimoda, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

BRAIN & DEVELOPMENT　38　(1)　47-53　2016/01

DOI： 10.1016/j.braindev.2015.04.010 　

ISSN： 0387-7604

eISSN： 1872-7131
High frequency oscillations are less frequent but more specific to epileptogenicity during rapid eye movement sleep Peer-reviewed

Rie Sakuraba, Masaki Iwasaki, Eiichi Okumura, Kazutaka Jin, Yosuke Kakisaka, Kazuhiro Kato, Teiji Tominaga, Nobukazu Nakasato

CLINICAL NEUROPHYSIOLOGY　127　(1)　179-186　2016/01

DOI： 10.1016/j.clinph.2015.05.019 　

ISSN： 1388-2457

eISSN： 1872-8952
Somatic BRAF c.1799T>A p.V600E Mosaicism syndrome characterized by a linear syringocystadenoma papilliferum, anaplastic astrocytoma, and ocular abnormalities. International-journal Peer-reviewed

Yuko Watanabe, Kosuke Shido, Tetsuya Niihori, Hidetaka Niizuma, Yu Katata, Chie Iizuka, Daiju Oba, Kunihiko Moriya, Yuka Saito-Nanjo, Masaei Onuma, Takeshi Rikiishi, Yoji Sasahara, Mika Watanabe, Setsuya Aiba, Ryuta Saito, Yukihiko Sonoda, Teiji Tominaga, Yoko Aoki, Shigeo Kure

American journal of medical genetics. Part A　170A　(1)　189-94　2016/01

DOI： 10.1002/ajmg.a.37376 　

ISSN： 1552-4825

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Genetic mosaicism for somatic mutations of oncogenes is common in genodermatoses, which can be complicated with extra-cutaneous abnormalities. Here we describe an infant with a congenital anaplastic astrocytoma, a linear syringocystadenoma papilliferum, and ocular abnormalities. The BRAF c.1799T>A p.V600E mutation was detected in both the brain and skin tumor cells but not in the blood or normal skin cells, suggesting somatic mosaicsism for the mutation. Clinically, the brain tumor gradually became life threatening without any response to conventional chemotherapies including carboplatin, etoposide, and temozolomide. Vemurafenib, a BRAF p.V600E inhibitor, was administered daily after the detection of the BRAF mutation. This single-agent therapy was dramatically effective against the anaplastic astrocytoma; the tumor regressed, the cerebrospinal fluid cell count and protein levels decreased to normal levels, and hydrocephalus resolved. Moreover, other lesions including a corneal cyst also responded to vemurafenib. The brain tumor continued shrinking after 6 months of treatment. We present a genodermatosis syndrome associated with BRAF c.1799T>A p.V600E mosaicism. This syndrome may represent a new entity in the mosaic RASopathies, partly overlapping with Schimmelpenning-Feuerstein-Mims syndrome, which is driven by mosaicism of HRAS and/or KRAS activating mutations. Screening for BRAF c.1799T>A p.V600E is especially useful for those with malignant tumors, because it is one of the most-druggable targets.
Transplantation of Unique Subpopulation of Fibroblasts, Muse Cells, Ameliorates Experimental Stroke Possibly via Robust Neuronal Differentiation Peer-reviewed

Hiroki Uchida, Takahiro Morita, Kuniyasu Niizuma, Yoshihiro Kushida, Yasumasa Kuroda, Shohei Wakao, Hiroyuki Sakata, Yoshiya Matsuzaka, Hajime Mushiake, Teiji Tominaga, Cesario V. Borlongan, Mari Dezawa

STEM CELLS　34　(1)　160-173　2016/01

DOI： 10.1002/stem.2206 　

ISSN： 1066-5099

eISSN： 1549-4918
Malignant transformation of diffuse astrocytoma to glioblastoma associated with newly developed BRAF V600E mutation Peer-reviewed

Masayuki Kanamori, Hiroyoshi Suzuki, Hidehiro Takei, Yukihiko Sonoda, Hiroshi Uenohara, Teiji Tominaga

BRAIN TUMOR PATHOLOGY　33　(1)　50-56　2016/01

DOI： 10.1007/s10014-015-0231-7 　

ISSN： 1433-7398

eISSN： 1861-387X
Evaluation of Fine Feeding System and Angioarchitecture of Giant Pituitary Adenoma-Implications for Establishment of Surgical Strategy Peer-reviewed

Yoshikazu Ogawa, Kenichi Sato, Yasushi Matsumoto, Teiji Tominaga

WORLD NEUROSURGERY　85　244-251　2016/01

DOI： 10.1016/j.wneu.2015.09.087 　

ISSN： 1878-8750

eISSN： 1878-8769
Temozolomide reverses doxorubicin resistance by inhibiting P-glycoprotein in malignant glioma cells Peer-reviewed

Rong Zhang, Ryuta Saito, Ichiyo Shibahara, Shinichiro Sugiyama, Masayuki Kanamori, Yukihiko Sonoda, Teiji Tominaga

JOURNAL OF NEURO-ONCOLOGY　126　(2)　235-242　2016/01

DOI： 10.1007/s11060-015-1968-x 　

ISSN： 0167-594X

eISSN： 1573-7373
Transient middle cerebral artery occlusion in mice induces neuronal expression of RNF213, a susceptibility gene for moyamoya disease Peer-reviewed

Mika Sato-Maeda, Miki Fujimura, Atsushi Kanoke, Yuiko Morita-Fujimura, Kuniyasu Niizuma, Teiji Tominaga

BRAIN RESEARCH　1630　50-55　2016/01

DOI： 10.1016/j.brainres.2015.10.055 　

ISSN： 0006-8993

eISSN： 1872-6240
Divergent clonal selection dominates medulloblastoma at recurrence Peer-reviewed

A. Sorana Morrissy, Livia Garzia, David J. H. Shih, Scott Zuyderduyn, Xi Huang, Patryk Skowron, Marc Remke, Florence M. G. Cavalli, Vijay Ramaswamy, Patricia E. Lindsay, Salomeh Jelveh, Laura K. Donovan, Xin Wang, Betty Luu, Kory Zayne, Yisu Li, Chelsea Mayoh, Nina Thiessen, Eloi Mercier, Karen L. Mungall, Yusanne Ma, Kane Tse, Thomas Zeng, Karey Shumansky, Andrew J. L. Roth, Sohrab Shah, Hamza Farooq, Noriyuki Kijima, Borja L. Holgado, John J. Y. Lee, Stuart Matan-Lithwick, Jessica Liu, Stephen C. Mack, Alex Manno, K. A. Michealraj, Carolina Nor, John Peacock, Lei Qin, Juri Reimand, Adi Rolider, Yuan Y. Thompson, Xiaochong Wu, Trevor Pugh, Adrian Ally, Mikhail Bilenky, Yaron S. N. Butterfield, Rebecca Carlsen, Young Cheng, Eric Chuah, Richard D. Corbett, Noreen Dhalla, An He, Darlene Lee, Haiyan I. Li, William Long, Michael Mayo, Patrick Plettner, Jenny Q. Qian, Jacqueline E. Schein, Angela Tam, Tina Wong, Inanc Birol, Yongjun Zhao, Claudia C. Faria, Jose Pimentel, Sofia Nunes, Tarek Shalaby, Michael Grotzer, Ian F. Pollack, Ronald L. Hamilton, Xiao-Nan Li, Anne E. Bendel, Daniel W. Fults, Andrew W. Walter, Toshihiro Kumabe, Teiji Tominaga, V. Peter Collins, Yoon-Jae Cho, Caitlin Hoffman, David Lyden, Jeffrey H. Wisoff, James H. Garvin, Duncan S. Stearns, Luca Massimi, Ulrich Schueller, Jaroslav Sterba, Karel Zitterbart, Stephanie Puget, Olivier Ayrault, Sandra E. Dunn, Daniela P. C. Tirapelli, Carlos G. Carlotti, Helen Wheeler, Andrew R. Hallahan, Wendy Ingram, Tobey J. MacDonald, Jeffrey J. Olson, Erwin G. Van Meir, Ji-Yeoun Lee, Kyu-Chang Wang, Seung-Ki Kim, Byung-Kyu Cho, Torsten Pietsch, Gudrun Fleischhack, Stephan Tippelt, Young Shin Ra, Simon Bailey, Janet C. Lindsey, Steven C. Clifford, Charles G. Eberhart, Michael K. Cooper, Roger J. Packer, Maura Massimino, Maria Luisa Garre, Ute Bartels, Uri Tabori, Cynthia E. Hawkins, Peter Dirks, Eric Bouffet, James T. Rutka, Robert J. Wechsler-Reya, William A. Weiss, Lara S. Collier, Adam J. Dupuy, Andrey Korshunov, David T. W. Jones, Marcel Kool, Paul A. Northcott, Stefan M. Pfister, David A. Largaespada, Andrew J. Mungall, Richard A. Moore, Nada Jabado, Gary D. Bader, Steven J. M. Jones, David Malkin, Marco A. Marra, Michael D. Taylor

NATURE　529　(7586)　351-+　2016/01

DOI： 10.1038/nature16478 　

ISSN： 0028-0836

eISSN： 1476-4687
Evaluation of a newly developed piezo actuator-driven pulsed water jet system for liver resection in a surviving swine animal model Peer-reviewed

Chikashi Nakanishi, Toru Nakano, Atsuhiro Nakagawa, Chiaki Sato, Masato Yamada, Naoki Kawagishi, Teiji Tominaga, Noriaki Ohuchi

BIOMEDICAL ENGINEERING ONLINE　15　9　2016/01

DOI： 10.1186/s12938-016-0126-9 　

ISSN： 1475-925X
A case of ruptured infectious anterior cerebral artery aneurysm treated by interposition graft bypass using the superficial temporal artery. Peer-reviewed

Abe T, Endo H, Shimizu H, Fujimura M, Endo T, Sakata H, Watanabe M, Tominaga T

Surgical neurology international　7　5　2016

DOI： 10.4103/2152-7806.173319 　

ISSN： 2229-5097
Grossly calcified choroid plexus concealing foramen of Monro meningiomas as an unusual cause of obstructive hydrocephalus. Peer-reviewed

Kawaguchi T, Fujimura M, Tominaga T

Asian journal of neurosurgery　11　(1)　74　2016/01

DOI： 10.4103/1793-5482.165779 　

ISSN： 1793-5482
Surgical and Endovascular Treatment for Spinal Arteriovenous Malformations Peer-reviewed

Toshiki Endo, Hidenori Endo, Kenichi Sato, Yasushi Matsumoto, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　56　(8)　457-464　2016

DOI： 10.2176/nmc.ra.2015-0327 　

ISSN： 0470-8105

eISSN： 1349-8029
Acute Subdural Hematoma in Infants with Abusive Head Trauma: A Literature Review Peer-reviewed

Hiroshi Karibe, Motonobu Kameyama, Toshiaki Hayashi, Ayumi Narisawa, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　56　(5)　264-273　2016

DOI： 10.2176/nmc.ra.2015-0308 　

ISSN： 0470-8105

eISSN： 1349-8029
Intraparenchymal infiltration of Rathke's cleft cysts manifesting as severe neurological deficits and hypopituitarism: 2 Case reports Peer-reviewed

Yoshikazu Ogawa, Mika Watanabe, Teiji Tominaga

BMC Research Notes　9　(1)　225　2016
Publisher: BioMed Central Ltd.
DOI： 10.1186/s13104-016-2035-1 　

ISSN： 1756-0500
Mechanism of Traumatic Brain Injury at Distant Locations After Exposure to Blast Waves: Preliminary Results from Animal and Phantom Experiments Peer-reviewed

Atsuhiro Nakagawa, Kiyonobu Ohtani, Keisuke Goda, Daisuke Kudo, Tatsuhiko Arafune, Toshikatsu Washio, Teiji Tominaga

INTRACRANIAL PRESSURE AND BRAIN MONITORING XV　122　3-7　2016

DOI： 10.1007/978-3-319-22533-3_1 　

ISSN： 0065-1419
Nasal cavity epithelioid hemangioendothelioma invading the anterior skull base. International-journal Peer-reviewed

Shogo Ogita, Toshiki Endo, Kazuhiro Nomura, Takenori Ogawa, Mika Watanabe, Kenjiro Higashi, Yukio Katori, Teiji Tominaga

Surgical neurology international　7　53-53　2016

DOI： 10.4103/2152-7806.181902 　

ISSN： 2229-5097

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BACKGROUND: Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor that frequently occurs in soft tissues. Patients suffer from local recurrence and remote metastasis because of its malignant potential. Here, we present a rare case of EHE that originated from nasal cavity and invaded intracranially through the anterior skull base. CASE DESCRIPTION: This is a 27-year-old woman who presented a local physician with intermittent epistaxis and a facial pain around her nose. Preoperative studies demonstrated that the tumor invaded into anterior skull base and the dura matter. Therefore, we performed combined skull base and transnasal surgery, which achieved complete resection of the tumor. Postoperative course of the patient was uneventful. No recurrence or distant metastasis was observed in the patient for 2 years following the radical resection. CONCLUSIONS: To date, four cases of EHE in the nasal cavity were reported. This is the first case in which EHE demonstrated invasive potentials with intracranial extension. Radical surgical resection plays an important role for better management of invasive paranasal EHE.
Verbal Dominant Memory Impairment and Low Risk for Post-operative Memory Worsening in Both Left and Right Temporal Lobe Epilepsy Associated with Hippocampal Sclerosis Peer-reviewed

Amr Farid Khalil, Masaki Iwasaki, Yoshiyuki Nishio, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　56　(11)　716-723　2016

DOI： 10.2176/nmc.oa.2016-0004 　

ISSN： 0470-8105

eISSN： 1349-8029
Non-invasive Evaluation for Epilepsy Surgery Peer-reviewed

Masaki Iwasaki, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　56　(10)　632-640　2016

DOI： 10.2176/nmc.ra.2016-0186 　

ISSN： 0470-8105

eISSN： 1349-8029
Difference in Transcranial Doppler Velocity and Patient Age between Proximal and Distal Middle Cerebral Artery Vasospasms after Aneurysmal Subarachnoid Hemorrhage. International-journal Peer-reviewed

Misaki Kohama, Shinichiro Sugiyama, Kenichi Sato, Hidenori Endo, Kuniyasu Niizuma, Toshiki Endo, Makoto Ohta, Yasushi Matsumoto, Miki Fujimura, Teiji Tominaga

Cerebrovascular diseases extra　6　(2)　32-9　2016

DOI： 10.1159/000447330 　

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BACKGROUND: Transcranial Doppler (TCD) is used to monitor cerebral vasospasm after subarachnoid hemorrhage (SAH), but its diagnostic ability is reported to be limited. Therefore, the purpose of this study was to investigate the relationship between the diagnosability of TCD and the localization of the vasospasm. METHODS: This retrospective study included 20 patients who presented with symptomatic vasospasm after SAH. All 20 patients underwent daily TCD examinations and cerebral angiography after the onset of delayed cerebral ischemia. We defined positive findings on TCD as a maximum flow velocity >200 cm/s or as a mean flow velocity >120 cm/s at the horizontal part of the middle cerebral artery (MCA). We also examined the site of vasospasm on cerebral angiography. RESULTS: Fourteen patients had true-positive findings on TCD examination, and cerebral angiography showed diffuse vasospasm involving the horizontal segment of the MCA. However, 6 patients had false-negative findings on TCD examination, and cerebral angiography showed vasospasm localized at the distal part of the MCA (the insular and/or cortical segments). The patients with proximal vasospasm were significantly younger than those with distal vasospasm. Blood flow velocity at initial TCD and the increase in velocity at the onset of vasospasm were lower and smaller, respectively, in the distal vasospasm group. CONCLUSIONS: In patients with cerebral vasospasm localized at the distal part of the MCA, flow velocity at the horizontal segment of the MCA did not increase to the level we defined as positive. To avoid such false negatives, a slight increase in velocity on TCD should be considered as positive in distal vasospasm cases, especially in older patients.
Computational Hemodynamic Analysis for the Diagnosis of Atherosclerotic Changes in Intracranial Aneurysms: A Proof-of-Concept Study Using 3 Cases Harboring Atherosclerotic and Nonatherosclerotic Aneurysms Simultaneously Peer-reviewed

Shin-ichiro Sugiyama, Hidenori Endo, Kuniyasu Niizuma, Toshiki Endo, Kenichi Funamoto, Makoto Ohta, Teiji Tominaga

COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE　2016　2386031　2016

DOI： 10.1155/2016/2386031 　

ISSN： 1748-670X

eISSN： 1748-6718
Intraspinal dissemination of intracranial hemangiopericytoma: Case report and literature review. Peer-reviewed

Ali HS, Endo T, Endo H, Murakami K, Tominaga T

Surgical neurology international　7　(Suppl 40)　S1016-S1020　2016

DOI： 10.4103/2152-7806.195585 　

ISSN： 2229-5097
Outcomes of Oculomotor Nerve Palsy Caused by Internal Carotid Artery Aneurysm: Comparison between Microsurgical Clipping and Endovascular Coiling Peer-reviewed

Masaki Mino, Masahiro Yoshida, Takahiro Morita, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　55　(12)　885-890　2015/12

DOI： 10.2176/nmc.oa.2014-0434 　

ISSN： 0470-8105

eISSN： 1349-8029
Experimental model of small subcortical infarcts in mice with long-lasting functional disabilities Peer-reviewed

Hiroki Uchida, Hiroyuki Sakata, Miki Fujimura, Kuniyasu Niizuma, Yoshihiro Kushida, Mari Dezawa, Teiji Tominaga

BRAIN RESEARCH　1629　318-328　2015/12

DOI： 10.1016/j.brainres.2015.10.039 　

ISSN： 0006-8993

eISSN： 1872-6240
Risk factors for meningitis after craniotomy in patients with subarachnoid hemorrhage due to anterior circulation aneurysms rupture Peer-reviewed

Takashi Inoue, Hiroaki Shimizu, Miki Fujimura, Kenichi Sato, Hidenori Endo, Kuniyasu Niizuma, Hiroyuki Sakata, Teiji Tominaga

CLINICAL NEUROLOGY AND NEUROSURGERY　139　302-306　2015/12

DOI： 10.1016/j.clineuro.2015.10.029 　

ISSN： 0303-8467

eISSN： 1872-6968
Resection of focal cortical dysplasia located in the upper pre-central gyrus Peer-reviewed

Samer Serag Eldin, Masaki Iwasaki, Yoshiyuki Nishio, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

EPILEPTIC DISORDERS　17　(4)　479-484　2015/12

DOI： 10.1684/epd.2015.0771 　

ISSN： 1294-9361

eISSN： 1950-6945
Pulsed Laser-induced Liquid Jet System for Treatment of Sellar and Parasellar Tumors: Safety Evaluation Peer-reviewed

Atsuhiro Nakagawa, Yoshikazu Ogawa, Kosaku Amano, Yudo Ishii, Shigeshi Tahara, Kentaro Horiguchi, Takakazu Kawamata, Shigetoshi Yano, Tatsuhiko Arafune, Toshikatsu Washio, Jun-ichi Kuratsu, Naokatsu Saeki, Yoshikazu Okada, Akira Teramoto, Teiji Tominaga

JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY　76　(6)　473-482　2015/11

DOI： 10.1055/s-0034-1396436 　

ISSN： 2193-6315

eISSN： 2193-6323
CD40/CD40L expression correlates with the survival of patients with glioblastomas and an augmentation in CD40 signaling enhances the efficacy of vaccinations against glioma models Peer-reviewed

Masashi Chonan, Ryuta Saito, Takuhiro Shoji, Ichiyo Shibahara, Masayuki Kanamori, Yukihiko Sonoda, Mika Watanabe, Toshiaki Kikuchi, Naoto Ishii, Teiji Tominaga

NEURO-ONCOLOGY　17　(11)　1453-1462　2015/11

DOI： 10.1093/neuonc/nov090 　

ISSN： 1522-8517

eISSN： 1523-5866
Shunt placement after cyst fenestration for middle cranial fossa arachnoid cysts in children Peer-reviewed

Tomomi Kimiwada, Toshiaki Hayashi, Ayumi Narisawa, Reizo Shirane, Teiji Tominaga

JOURNAL OF NEUROSURGERY-PEDIATRICS　16　(5)　533-539　2015/11

DOI： 10.3171/2015.3.PEDS14573 　

ISSN： 1933-0707

eISSN： 1933-0715
Interdigitated craniotomy: a simple technique to fix a bone flap with only a single plate Peer-reviewed

Noboru Takahashi, Kazunori Fujiwara, Keiichi Saito, Teiji Tominaga

JOURNAL OF NEUROSURGERY　123　(4)　1055-1058　2015/10

DOI： 10.3171/2014.10.JNS141034 　

ISSN： 0022-3085

eISSN： 1933-0693
Diffuse large B cell lymphoma of the cranial vault: two case reports Peer-reviewed

Ryosuke Tashiro, Masayuki Kanamori, Hiroyoshi Suzuki, Akihiro Utsunomiya, Kuniaki Meguro, Hiroshi Uenohara, Teiji Tominaga

BRAIN TUMOR PATHOLOGY　32　(4)　275-280　2015/10

DOI： 10.1007/s10014-015-0225-5 　

ISSN： 1433-7398

eISSN： 1861-387X
Cerebral Blood Flow after Acute Bypass with Parent Artery Trapping in Patients with Ruptured Supraclinoid Internal Carotid Artery Aneurysms Peer-reviewed

Hidenori Endo, Miki Fujimura, Hiroaki Shimizu, Takashi Inoue, Kenichi Sato, Kuniyasu Niizuma, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　24　(10)　2358-2368　2015/10

DOI： 10.1016/j.jstrokecerebrovasdis.2015.06.028 　

ISSN： 1052-3057

eISSN： 1532-8511
Prognostic factors of craniopharyngioma with special reference to autocrine/paracrine signaling: underestimated implication of growth hormone receptor Peer-reviewed

Yoshikazu Ogawa, Mika Watanabe, Teiji Tominaga

ACTA NEUROCHIRURGICA　157　(10)　1731-1740　2015/10

DOI： 10.1007/s00701-015-2519-0 　

ISSN： 0001-6268

eISSN： 0942-0940
Temporal profile of the vascular anatomy evaluated by 9.4-tesla magnetic resonance angiography and histological analysis in mice with the R4859K mutation of RNF213, the susceptibility gene for moyamoya disease Peer-reviewed

Atsushi Kanoke, Miki Fujimura, Kuniyasu Niizuma, Akira Ito, Hiroyuki Sakata, Mika Sato-Maeda, Yuiko Morita-Fujimura, Shigeo Kure, Teiji Tominaga

BRAIN RESEARCH　1624　497-505　2015/10

DOI： 10.1016/j.brainres.2015.07.039 　

ISSN： 0006-8993

eISSN： 1872-6240
Craniopharyngiomas Presenting with Nonobstructive Hydrocephalus: Underlying Influence of Subarachnoidal Hemorrhage. Two Case Reports Peer-reviewed

Tomohiro Kawaguchi, Yoshikazu Ogawa, Mika Watanabe, Teiji Tominaga

JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY　76　(5)　418-423　2015/09

DOI： 10.1055/s-0034-1382784 　

ISSN： 2193-6315

eISSN： 2193-6323
Sellar and parasellar tumor removal without discontinuing antithrombotic therapy Peer-reviewed

Yoshikazu Ogawa, Teiji Tominaga

JOURNAL OF NEUROSURGERY　123　(3)　794-798　2015/09

DOI： 10.3171/2014.9.JNS141088 　

ISSN： 0022-3085

eISSN： 1933-0693
Occult dual pathology in mesial temporal lobe epilepsy Peer-reviewed

Shin-ichiro Osawa, Masaki Iwasaki, Hiroyoshi Suzuki, Nobukazu Nakasato, Teiji Tominaga

NEUROLOGICAL SCIENCES　36　(9)　1743-1745　2015/09

DOI： 10.1007/s10072-015-2268-0 　

ISSN： 1590-1874

eISSN： 1590-3478
Use of actuator-driven pulsed water jet in brain and spinal cord cavernous malformations resection Peer-reviewed

Toshiki Endo, Yoko Takahashi, Atsuhiro Nakagawa, Kuniyasu Niizuma, Miki Fujimura, Teiji Tominaga

Clinical Neurosurgery　11　394-403　2015/09/01
Publisher: Lippincott Williams and Wilkins
DOI： 10.1227/NEU.0000000000000867 　

ISSN： 0148-396X 0069-4827
Endovascular parent artery occlusion for distal giant aneurysm of the posterior cerebral artery Peer-reviewed

Hiroki Uchida, Teiji Tominaga, Masahiro Yoshida, Masaki Mino

Neurological Surgery　43　(9)　849-854　2015/09/01
Publisher: Igaku-Shoin Ltd
DOI： 10.11477/mf.1436203132 　

ISSN： 1882-1251 0301-2603
High-grade Cerebral Arteriovenous Malformation Treated with Targeted Embolization of a Ruptured Site: Wall Enhancement of an Intranidal Aneurysm as a Sign of Ruptured Site Peer-reviewed

Shunsuke Omodaka, Hidenori Endo, Miki Fujimura, Kuniyasu Niizuma, Kenichi Sato, Yasushi Matsumoto, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　55　(10)　813-817　2015/09

DOI： 10.2176/nmc.cr.2015-0052 　

ISSN： 0470-8105

eISSN： 1349-8029
Significance of Cerebral Blood Flow Analysis in the Acute Stage after Revascularization Surgery for Moyamoya Disease Peer-reviewed

Miki Fujimura, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　55　(10)　775-781　2015/09

DOI： 10.2176/nmc.ra.2015-0063 　

ISSN： 0470-8105

eISSN： 1349-8029
Outflow Occlusion with Occipital Artery-Posterior Inferior Cerebellar Artery Bypass for Growing Vertebral Artery Fusiform Aneurysm with Ischemic Onset: A Case Report Peer-reviewed

Ryuzaburo Kochi, Hidenori Endo, Miki Fujimura, Kenichi Sato, Shin-ichiro Sugiyama, Shin-ichiro Osawa, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　24　(8)　E223-E226　2015/08

DOI： 10.1016/j.jstrokecerebrovasdis.2015.04.020 　

ISSN： 1052-3057

eISSN： 1532-8511
Therapeutic Clip Occlusion of the Anterior Choroidal Artery Involved with Partially Thrombosed Fusiform Aneurysm: A Case Report Peer-reviewed

Sherif Rashad, Hidenori Endo, Ahmed Elsayed Sultan, Hiroaki Shimizu, Miki Fujimura, Kenichi Sato, Yasushi Matsumoto, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　24　(8)　E227-E230　2015/08

DOI： 10.1016/j.jstrokecerebrovasdis.2015.04.024 　

ISSN： 1052-3057

eISSN： 1532-8511
Human chorionic gonadotropin is expressed virtually in all intracranial germ cell tumors Peer-reviewed

Hirokazu Takami, Shintaro Fukushima, Kohei Fukuoka, Tomonari Suzuki, Takaaki Yanagisawa, Yuko Matsushita, Taishi Nakamura, Hideyuki Arita, Akitake Mukasa, Nobuhito Saito, Masayuki Kanamori, Toshihiro Kumabe, Teiji Tominaga, Keiichi Kobayashi, Motoo Nagane, Toshihiko Iuchi, Kaoru Tamura, Taketoshi Maehara, Kazuhiko Sugiyama, Mitsutoshi Nakada, Yonehiro Kanemura, Masahiro Nonaka, Kiyotaka Yokogami, Hideo Takeshima, Yoshitaka Narita, Soichiro Shibui, Yoichi Nakazato, Ryo Nishikawa, Koichi Ichimura, Masao Matsutani

JOURNAL OF NEURO-ONCOLOGY　124　(1)　23-32　2015/08

DOI： 10.1007/s11060-015-1809-y 　

ISSN： 0167-594X

eISSN： 1573-7373
Ruptured Cerebral Microaneurysm Diagnosed by 3-Dimensional Fast Spin-Echo T1 Imaging with Variable Flip Angles Peer-reviewed

Hidenori Endo, Kuniyasu Niizuma, Miki Fujimura, Kenichi Sato, Takashi Inoue, Shin-ichiro Osawa, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　24　(8)　E231-E235　2015/08

DOI： 10.1016/j.jstrokecerebrovasdis.2015.04.031 　

ISSN： 1052-3057

eISSN： 1532-8511
Consistent delayed unilateral neuronal death after modified transient focal cerebral ischemia in mice that mimics neuronal injury after transient global cerebral ischemia Peer-reviewed

Yasuo Nishijima, Kuniyasu Niizuma, Miki Fujimura, Yosuke Akamatsu, Hiroaki Shimizu, Teiji Tominaga

JOURNAL OF NEUROSURGERY　123　(1)　243-253　2015/07

DOI： 10.3171/2014.9.JNS14778 　

ISSN： 0022-3085

eISSN： 1933-0693
Local Vasogenic Edema without Cerebral Hyperperfusion after Direct Revascularization Surgery for Moyamoya Disease Peer-reviewed

Hiroyuki Sakata, Miki Fujimura, Shunji Mugikura, Kenichi Sato, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　24　(7)　E179-E184　2015/07

DOI： 10.1016/j.jstrokecerebrovasdis.2015.03.050 　

ISSN： 1052-3057

eISSN： 1532-8511
Prediction model for 3-year rupture risk of unruptured cerebral aneurysms in Japanese patients Peer-reviewed

Shinjiro Tominari, Akio Morita, Toshihiro Ishibashi, Tomosato Yamazaki, Hiroyuki Takao, Yuichi Murayama, Makoto Sonobe, Masahiro Yonekura, Nobuhito Saito, Yoshiaki Shiokawa, Isao Date, Teiji Tominaga, Kazuhiko Nozaki, Kiyohiro Houkin, Susumu Miyamoto, Takaaki Kirino, Kazuo Hashi, Takeo Nakayama

ANNALS OF NEUROLOGY　77　(6)　1050-1059　2015/06

DOI： 10.1002/ana.24400 　

ISSN： 0364-5134

eISSN： 1531-8249
Required knowledge for stroke specialists (11) management of moyamoya disease Peer-reviewed

Miki Fujimura, Teiji Tominaga

Neurological Surgery　43　(6)　557-565　2015/06/01
Publisher: Igaku-Shoin Ltd
DOI： 10.11477/mf.1436203073 　

ISSN： 1882-1251 0301-2603
Targeting of apoptotic cells using functionalized Fe2O3 nanoparticles Peer-reviewed

Moataz Mekawy, Atsushi Saito, Hiroaki Shimizu, Teiji Tominaga

Nanomaterials　5　(2)　874-884　2015/05/26
Publisher: MDPI AG
DOI： 10.3390/nano5020874 　

ISSN： 2079-4991
Current Status of Revascularization Surgery for Moyamoya Disease: Special Consideration for Its 'Internal Carotid-External Carotid (IC-EC) Conversion' as the Physiological Reorganization System Peer-reviewed

Miki Fujimura, Teiji Tominaga

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　236　(1)　45-53　2015/05

DOI： 10.1620/tjem.236.45 　

ISSN： 0040-8727

eISSN： 1349-3329
Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients Peer-reviewed

Masayuki Kanamori, Tsuyoshi Higa, Yukihiko Sonoda, Shohei Murakami, Mina Dodo, Hiroshi Kitamura, Keiko Taguchi, Tatsuhiro Shibata, Mika Watanabe, Hiroyoshi Suzuki, Ichiyo Shibahara, Ryuta Saito, Yoji Yamashita, Toshihiro Kumabe, Masayuki Yamamoto, Hozumi Motohashi, Teiji Tominaga

NEURO-ONCOLOGY　17　(4)　555-565　2015/04

DOI： 10.1093/neuonc/nou282 　

ISSN： 1522-8517

eISSN： 1523-5866
Association between molecular alterations and tumor location and MRI characteristics in anaplastic gliomas Peer-reviewed

Yukihiko Sonoda, Ichiyoo Shibahara, Tomohiro Kawaguchi, Ryuta Saito, Masayuki Kanamori, Mika Watanabe, Hiroyoshi Suzuki, Toshihiro Kumabe, Teiji Tominaga

BRAIN TUMOR PATHOLOGY　32　(2)　99-104　2015/04

DOI： 10.1007/s10014-014-0211-3 　

ISSN： 1433-7398

eISSN： 1861-387X
Water Supply Facility Damage and Water Resource Operation at Disaster Base Hospitals in Miyagi Prefecture in the Wake of the Great East Japan Earthquake Peer-reviewed

Takashi Matsumura, Shizuka Osaki, Daisuke Kudo, Hajime Furukawa, Atsuhiro Nakagawa, Yoshiko Abe, Satoshi Yamanouchi, Shinichi Egawa, Teiji Tominaga, Shigeki Kushimoto

PREHOSPITAL AND DISASTER MEDICINE　30　(2)　193-198　2015/04

DOI： 10.1017/S1049023X15000084 　

ISSN： 1049-023X

eISSN： 1945-1938
Rosette-forming Glioneuronal Tumor: Rare Case Presented with Spontaneous Disappearance of Contrast Enhancement. Peer-reviewed

Shinya Haryu, Ryuta Saito, Masayuki Kanamori, Yukihiko Sonoda, Toshihiro Kumabe, Mika Watanabe, Faruk Tonga, Teiji Tominaga

NMC case report journal　2　(2)　65-67　2015/04

DOI： 10.2176/nmccrj.2014-0077 　

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This report presents rosette-forming glioneuronal tumor (RGNT) of the tectum in a 24-year-old woman in whom spontaneous disappearance of contrast enhancement (CE) on magnetic resonance (MR) imaging was observed during 9-year follow-up period before therapeutic intervention. MR imaging obtained 9 years ago when she first visited local hospital with headaches showed a mass of the brain stem with CE. Follow-up MR imaging showed disappearance of CE without tumor growth. Nine years later, she was admitted to our hospital with headache and nausea, due to obstructive hydrocephalus. She underwent endoscopic third ventriculostomy (ETV) and tumor biopsy. Histological study revealed RGNT. To our knowledge, this is the first report presenting that the RGNT may show spontaneous disappearance of CE without tumor growth. It is unclear what this phenomenon means, however, knowledge of this phenomenon may be helpful for correct diagnosis and for follow up of RGNT.
A significant increase in intraoperative flash visual evoked potential amplitude during craniopharyngioma surgery-case report Peer-reviewed

Tomohiro Kawaguchi, Yoshikazu Ogawa, Satoru Fujiwara, Teiji Tominaga

Neurological Surgery　43　(4)　323-329　2015/04/01
Publisher: Igaku-Shoin Ltd
DOI： 10.11477/mf.1436203015 　

ISSN： 1882-1251 0301-2603
[A case of atherothrombotic embolization developing with slowly progressive symptoms and requiring differential diagnosis from metastatic tumor recurrence]. Peer-reviewed

Sho Umegaki, Ryuta Saito, Yosuke Akamatsu, Hiroyuki Sakata, Ken-Ichi Sato, Miki Fujimura, Yukihiko Sonoda, Teiji Tominaga

No shinkei geka. Neurological surgery　43　(4)　339-43　2015/04

DOI： 10.11477/mf.1436203017 　

ISSN： 0301-2603

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We report a case of atherothrombotic embolization that developed with slowly progressive symptoms and required differential diagnosis from metastatic tumor recurrence. A 64-year-old man with a history of lung cancer and metastatic brain tumor was carefully followed at our outpatient department for tumor recurrence. Five years after surgery for brain metastasis and whole brain radiation therapy, he had no recurrence and systemic disease was well controlled. At a routine follow up in October 2013, he complained of slight right arm dysesthesia. Follow up brain magnetic resonance (MR) imaging revealed no lesion. Two months later, he developed right hemiparesthesia and gait disturbance. Spinal MR imaging was unremarkable. However, at a routine follow up in January 2014, multiple enhancements were detected near the resection cavity and regions delineating the sulci. At first, this was diagnosed as tumor recurrence. However, 3 days later, additional MR imaging detected new multiple small infarctions after worsening right hemiparesis and dysarthria. With the diagnosis of embolic stroke, we searched for an embolic source. Cardiogenic embolization and carotid bifurcation stenosis studies were negative, but severe stenosis and thrombosis were detected near the left common carotid artery origin. This site was in the field of radiation the patient received as treatment for primary lung cancer.
Required knowledge for stroke specialists (9) asymptomatic cerebrovascular diseases Peer-reviewed

Kuniyasu Niizuma, Teiji Tominaga

Neurological Surgery　43　(4)　357-368　2015/04/01
Publisher: Igaku-Shoin Ltd
DOI： 10.11477/mf.1436203022 　

ISSN： 1882-1251 0301-2603
Intraventricular Hemorrhage on Initial Computed Tomography as Marker of Diffuse Axonal Injury after Traumatic Brain Injury Peer-reviewed

Daddy Mata-Mbemba, Shunji Mugikura, Atsuhiro Nakagawa, Takaki Murata, Yumiko Kato, Yasuko Tatewaki, Li Li, Kei Takase, Kiyoshi Ishii, Shigeki Kushimoto, Teiji Tominaga, Shoki Takahashi

JOURNAL OF NEUROTRAUMA　32　(5)　359-365　2015/03

DOI： 10.1089/neu.2014.3453 　

ISSN： 0897-7151

eISSN： 1557-9042
Exclusively epidural spinal metameric arteriovenous shunts: case report and literature review Peer-reviewed

Alaa Elkordy, Toshiki Endo, Kenichi Sato, Yukihiko Sonoda, Akira Takahashi, Teiji Tominaga

SPINE JOURNAL　15　(3)　E15-E22　2015/03

DOI： 10.1016/j.spinee.2014.11.022 　

ISSN： 1529-9430

eISSN： 1878-1632
Diagnosis of Moyamoya Disease: International Standard and Regional Differences Peer-reviewed

Miki Fujimura, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　55　(3)　189-193　2015/03

DOI： 10.2176/nmcsa.2014-0307 　

ISSN： 0470-8105

eISSN： 1349-8029
Impaired Leptomeningeal Collateral Flow Contributes to the Poor Outcome following Experimental Stroke in the Type 2 Diabetic Mice Peer-reviewed

Yosuke Akamatsu, Yasuo Nishijima, Chih Cheng Lee, Shih Yen Yang, Lei Shi, Lin An, Ruikang K. Wang, Teiji Tominaga, Jialing Liu

JOURNAL OF NEUROSCIENCE　35　(9)　3851-3864　2015/03

DOI： 10.1523/JNEUROSCI.3838-14.2015 　

ISSN： 0270-6474
Clinical features of intracerebral hemorrhage under antithrombotic therapy in the warfarin era Peer-reviewed

Misaki Kohama, Masahiro Yoshida, Masaki Mino, Teiji Tominaga

Neurological Surgery　43　(3)　199-205　2015/03/01
Publisher: Igaku-Shoin Ltd
DOI： 10.11477/mf.1436202987 　

ISSN： 1882-1251 0301-2603
A case of akin moyamoya disease associated with type-I diabetes mellitus managed by extracranial-intracranial bypass Peer-reviewed

Yosuke Akamatsu, Miki Fujimura, Hiroyuki Sakata, Hidenori Endo, Ryo Itabashi, Teiji Tominaga

Neurological Surgery　43　(3)　227-233　2015/03/01
Publisher: Igaku-Shoin Ltd
DOI： 10.11477/mf.1436202991 　

ISSN： 1882-1251 0301-2603
Quantitative analysis of early postoperative cerebral blood flow contributes to the prediction and diagnosis of cerebral hyperperfusion syndrome after revascularization surgery for moyamoya disease Peer-reviewed

Miki Fujimura, Kuniyasu Niizuma, Hidenori Endo, Kenichi Sato, Takashi Inoue, Hiroaki Shimizu, Teiji Tominaga

NEUROLOGICAL RESEARCH　37　(2)　131-138　2015/02

DOI： 10.1179/1743132814Y.0000000432 　

ISSN： 0161-6412

eISSN： 1743-1328
OX40 ligand expressed in glioblastoma modulates adaptive immunity depending on the microenvironment: a clue for successful immunotherapy Peer-reviewed

Ichiyo Shibahara, Ryuta Saito, Rong Zhang, Masashi Chonan, Takuhiro Shoji, Masayuki Kanamori, Yukihiko Sonoda, Toshihiro Kumabe, Masahiko Kanehira, Toshiaki Kikuchi, Takanori So, Takashi Watanabe, Hiroaki Takahashi, Erina Iwabuchi, Yuetsu Tanaka, Yukiko Shibahara, Hironobu Sasano, Naoto Ishii, Teiji Tominaga

MOLECULAR CANCER　14　41　2015/02

DOI： 10.1186/s12943-015-0307-3 　

ISSN： 1476-4598
Malignant clinical features of anaplastic gliomas without IDH mutation Peer-reviewed

Ichiyo Shibahara, Yukihiko Sonoda, Takuhiro Shoji, Masayuki Kanamori, Ryuta Saito, Tomoo Inoue, Tomohiro Kawaguchi, Yoji Yamashita, Takashi Watanabe, Toshihiro Kumabe, Mika Watanabe, Hiroyoshi Suzuki, Teiji Tominaga

NEURO-ONCOLOGY　17　(1)　136-144　2015/01

DOI： 10.1093/neuonc/nou112 　

ISSN： 1522-8517

eISSN： 1523-5866
Enhanced post-ischemic angiogenesis in mice lacking RNF213; a susceptibility gene for moyamoya disease Peer-reviewed

Akira Ito, Miki Fujimura, Kuniyasu Niizuma, Atsushi Kanoke, Hiroyuki Sakata, Yuiko Morita-Fujimura, Atsuo Kikuchi, Shigeo Kure, Teiji Tominaga

BRAIN RESEARCH　1594　310-320　2015/01

DOI： 10.1016/j.brainres.2014.11.014 　

ISSN： 0006-8993

eISSN： 1872-6240
Audit Trail Management System in Community Health Care Information Network Peer-reviewed

Naoki Nakamura, Masaharu Nakayama, Jun Nakaya, Teiji Tominaga, Takuo Suganuma, Norio Shiratori

Studies in Health Technology and Informatics　216　1080　2015
Publisher: IOS Press
DOI： 10.3233/978-1-61499-564-7-1080 　

ISSN： 1879-8365 0926-9630

eISSN： 1879-8365
Interhemispheric Vertical Hemispherotomy: A Single Center Experience Peer-reviewed

Masaki Iwasaki, Mitsugu Uematsu, Shin-ichiro Osawa, Yoshiteru Shimoda, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

PEDIATRIC NEUROSURGERY　50　(5)　295-300　2015

DOI： 10.1159/000437145 　

ISSN： 1016-2291

eISSN： 1423-0305
Electro-and magneto-encephalographic spike source localization of small focal cortical dysplasia in the dorsal peri-rolandic region Peer-reviewed

Hisashi Itabashi, Kazutaka Jin, Masaki Iwasaki, Eiichi Okumura, Akitake Kanno, Kazuhiro Kato, Teiji Tominaga, Ryuta Kawashima, Nobukazu Nakasato

CLINICAL NEUROPHYSIOLOGY　125　(12)　2358-2363　2014/12

DOI： 10.1016/j.clinph.2014.02.028 　

ISSN： 1388-2457

eISSN： 1872-8952
Intracerebral cystic rhabdoid papillary meningioma in an 11-year-old patient Peer-reviewed

Wenting Jia, Yukihiko Sonoda, Ryuta Saito, Toshiki Endo, Mika Watanabe, Teiji Tominaga

CHILDS NERVOUS SYSTEM　30　(12)　2151-2155　2014/12

DOI： 10.1007/s00381-014-2470-z 　

ISSN： 0256-7040

eISSN： 1433-0350
Spontaneous Alteration from Rathke's Cleft Cyst to Craniopharyngioma-Possible Involvement of Transformation Between These Pathologies Peer-reviewed

Yoshikazu Ogawa, Mika Watanabe, Teiji Tominaga

ENDOCRINE PATHOLOGY　25　(4)　422-426　2014/12

DOI： 10.1007/s12022-014-9328-5 　

ISSN： 1046-3976

eISSN： 1559-0097
Increased vascular MMP-9 in mice lacking RNF213: moyamoya disease susceptibility gene Peer-reviewed

Shinya Sonobe, Miki Fujimura, Kuniyasu Niizuma, Taku Fujimura, Sadanori Furudate, Yasuo Nishijima, Shigeo Kure, Teiji Tominaga

NEUROREPORT　25　(18)　1442-1446　2014/12

DOI： 10.1097/WNR.0000000000000289 　

ISSN： 0959-4965

eISSN： 1473-558X
Radiology Diagnostic Devices Under Emergency Electric Power at Disaster Base Hospitals During the Acute Phase of the Great East Japan Earthquake: Results of a Survey of All Disaster Base Hospitals in Miyagi Prefecture Peer-reviewed

Shota Maezawa, Daisuke Kudo, Hajime Furukawa, Atsuhiro Nakagawa, Satoshi Yamanouchi, Takashi Matsumura, Shinichi Egawa, Teiji Tominaga, Shigeki Kushimoto

DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS　8　(6)　548-552　2014/12

DOI： 10.1017/dmp.2014.134 　

ISSN： 1935-7893

eISSN： 1938-744X
Novel pulsed water jet system permits off-clamp partial nephrectomy in swine Peer-reviewed

Shinichi Yamashita, Yoshihiro Kamiyama, Atsuhiro Nakagawa, Yasuhiro Kaiho, Teiji Tominaga, Yoichi Arai

INTERNATIONAL JOURNAL OF UROLOGY　21　(11)　1181-1182　2014/11

DOI： 10.1111/iju.12538 　

ISSN： 0919-8172

eISSN： 1442-2042
Practical surgical indicators to identify candidates for radical resection of insulo-opercular gliomas Peer-reviewed

Tomohiro Kawaguchi, Toshihiro Kumabe, Ryuta Saito, Masayuki Kanamori, Masaki Iwasaki, Yon Yamashita, Yukihiko Sonoda, Teiji Tominaga

JOURNAL OF NEUROSURGERY　121　(5)　1124-1132　2014/11

DOI： 10.3171/2014.7.JNS13899 　

ISSN： 0022-3085

eISSN： 1933-0693
Usefulness of Laser Speckle Flowgraphy for the Assessment of Ocular Blood Flow in Extracranial-Intracranial Bypass Peer-reviewed

Shunsuke Omodaka, Hidenori Endo, Hiroshi Doi, Hiroaki Shimizu, Miki Fujimura, Naoko Aizawa, Toru Nakazawa, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　23　(10)　E445-E448　2014/11

DOI： 10.1016/j.jstrokecerebrovasdis.2014.06.021 　

ISSN： 1052-3057

eISSN： 1532-8511
[Usefulness of pulsed water jet in dissecting sphenoid ridge meningioma while preserving arteries]. Peer-reviewed

Toshiki Endo, Atsuhiro Nakagawa, Miki Fujimura, Yukihiko Sonoda, Hiroaki Shimizu, Teiji Tominaga

No shinkei geka. Neurological surgery　42　(11)　1019-25　2014/11

DOI： 10.11477/mf.1436200025 　

ISSN： 0301-2603

More details Close

We report the utility of a pulsed water jet device in meningioma surgery. The presented case is that of a 61-year-old woman with left visual disturbance. MRI demonstrated heterogeneously enhanced mass with intratumoral hemorrhage, indicating sphenoid ridge meningioma on her left side. The tumor invaded the cavernous sinus and left optic canal, engulfing the internal carotid artery in the carotid cistern and encased middle cerebral arteries. During the operation, the pulsed water jet device was useful for dissecting the tumor away from the arteries since it was safe in light of preserving parent arteries. The jet did not cause any vascular injury and did not induce vasospasm as shown by postoperative symptomatology and MRIs. With the aid of pulsed water jet, we could achieve total resection of the tumor except for the piece within the cavernous sinus. The patient had no new neurological deficits after the operation. We consider the pulsed water jet as a useful device, especially when the need to dissect meningioma from parent arteries exists. The jet can help neurosurgeons simultaneously achieve tumor resection and preservation of blood vessels.
Surgical Management of Traumatic Acute Subdural Hematoma in Adults: A Review Peer-reviewed

Hiroshi Karibe, Toshiaki Hayashi, Takayuki Hirano, Motonobu Kameyama, Atsuhiro Nakagawa, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　54　(11)　887-894　2014/11

DOI： 10.2176/nmc.ra.2014-0204 　

ISSN： 0470-8105

eISSN： 1349-8029
Experimental Application of Piezoelectric Actuator-Driven Pulsed Water Jets in Retinal Vascular Surgery Peer-reviewed

Hiroshi Kunikata, Yuji Tanaka, Naoko Aizawa, Atsuhiro Nakagawa, Teiji Tominaga, Toru Nakazawa

TRANSLATIONAL VISION SCIENCE & TECHNOLOGY　3　(6)　10　2014/11

DOI： 10.1167/tvst.3.6.10 　

ISSN： 2164-2591
Efficacy of Superficial Temporal Artery-Middle Cerebral Artery Double Anastomoses in a Patient with Rapidly Progressive Moyamoya Disease: Case Report Peer-reviewed

Michiko Yokosawa, Toshiaki Hayashi, Reizo Shirane, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　54　(10)　836-840　2014/10

DOI： 10.2176/nmc.cr.2013-0139 　

ISSN： 0470-8105

eISSN： 1349-8029
Conformational Change in Transfer RNA Is an Early Indicator of Acute Cellular Damage Peer-reviewed

Eikan Mishima, Chisako Inoue, Daisuke Saigusa, Ryusuke Inoue, Koki Ito, Yusuke Suzuki, Daisuke Jinno, Yuri Tsukui, Yosuke Akamatsu, Masatake Araki, Kimi Araki, Ritsuko Shimizu, Haruka Shinke, Takehiro Suzuki, Yoichi Takeuchi, Hisato Shima, Yasutoshi Akiyama, Takafumi Toyohara, Chitose Suzuki, Yoshikatu Saiki, Teiji Tominaga, Shigehito Miyagi, Naoki Kawagisihi, Tomoyoshi Soga, Takayoshi Ohkubo, Kenichi Yamamura, Yutaka Imai, Satohiro Masuda, Venkata Sabbisetti, Takaharu Ichimura, David B. Mount, Joseph V. Bonventre, Sadayoshi Ito, Yoshihisa Tomioka, Kunihiko Itoh, Takaaki Abe

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　25　(10)　2316-2326　2014/10

DOI： 10.1681/ASN.2013091001 　

ISSN： 1046-6673

eISSN： 1533-3450
Cavernous malformation of the optic pathway mimicking optic glioma: a case report Peer-reviewed

Yui Mano, Toshihiro Kumabe, Ryuta Saito, Mika Watanabe, Teiji Tominaga

CHILDS NERVOUS SYSTEM　30　(10)　1753-1758　2014/10

DOI： 10.1007/s00381-014-2465-9 　

ISSN： 0256-7040

eISSN： 1433-0350
Outcome and mid-term prognosis after maximum and radical removal of craniopharyngiomas with the priority to the extended transsphenoidal approach-A single center experience Peer-reviewed

Yoshikazu Ogawa, Tomohiro Kawaguchi, Teiji Tominaga

CLINICAL NEUROLOGY AND NEUROSURGERY　125　41-46　2014/10

DOI： 10.1016/j.clineuro.2014.07.014 　

ISSN： 0303-8467

eISSN： 1872-6968
Hypothermia in Victims of the Great East Japan Earthquake: A Survey in Miyagi Prefecture Peer-reviewed

Hajime Furukawa, Daisuke Kudo, Atsuhiro Nakagawa, Takashi Matsumura, Yoshiko Abe, Ryota Konishi, Satoshi Yamanouchi, Satoru Ishibashi, Masakazu Kobayashi, Norio Narita, Toshikatsu Washio, Tatsuhiko Arafune, Teiji Tominaga, Shigeki Kushimoto

DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS　8　(5)　379-389　2014/10

DOI： 10.1017/dmp.2014.70 　

ISSN： 1935-7893

eISSN： 1938-744X
Development of Moyamoya Disease in Pregnancy and Puerperium: Case Report Peer-reviewed

Yosuke Akamatsu, Miki Fujimura, Hiroshi Uenohara, Hiroaki Shimizu, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　54　(10)　824-826　2014/10

DOI： 10.2176/nmc.cr.2014-0071 　

ISSN： 0470-8105

eISSN： 1349-8029
Maximum Preservation of the Media in Carotid Endarterectomy Peer-reviewed

Kuniyasu Niizuma, Hiroaki Shimizu, Takashi Inoue, Mika Watanabe, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　54　(10)　812-818　2014/10

DOI： 10.2176/nmc.tn.2014-0202 　

ISSN： 0470-8105

eISSN： 1349-8029
Cervical Perimedullary Arteriovenous Shunts: A Study of 22 Consecutive Cases With a Focus on Angioarchitecture and Surgical Approaches Peer-reviewed

Toshiki Endo, Hiroaki Shimizu, Kenichi Sato, Kuniyasu Niizuma, Ryushi Kondo, Yasushi Matsumoto, Akira Takahashi, Teiji Tominaga

NEUROSURGERY　75　(3)　238-248　2014/09

DOI： 10.1227/NEU.0000000000000401 　

ISSN： 0148-396X

eISSN： 1524-4040
A Case of Bilateral Giant Internal Carotid Artery Aneurysms at the Cavernous Portion Managed by 2-stage Extracranial-Intracranial Bypass with Parent Artery Occlusion: Consideration for Bypass Selection and Timing of Surgeries Peer-reviewed

Miki Fujimura, Kenichi Sato, Naoto Kimura, Takashi Inoue, Hiroaki Shimizu, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　23　(8)　E393-E398　2014/09

DOI： 10.1016/j.jstrokecerebrovasdis.2014.02.020 　

ISSN： 1052-3057

eISSN： 1532-8511
Efficacy of Extracranial-Intracranial Bypass for Progressive Middle Cerebral Artery Occlusion Associated with Active Sjogren's Syndrome: Case Report Peer-reviewed

Hiroyuki Sakata, Miki Fujimura, Kenichi Sato, Hiroaki Shimizu, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　23　(8)　E399-E402　2014/09

DOI： 10.1016/j.jstrokecerebrovasdis.2014.02.022 　

ISSN： 1052-3057

eISSN： 1532-8511
Diagnostic pitfalls of hyperprolactinemia: The importance of sequential pituitary imaging Peer-reviewed

Tomohiro Kawaguchi, Yoshikazu Ogawa, Teiji Tominaga

BMC Research Notes　7　(1)　555　2014/08/20
Publisher: BioMed Central Ltd.
DOI： 10.1186/1756-0500-7-555 　

ISSN： 1756-0500
SMTP-7, a new thrombolytic agent, decreases hemorrhagic transformation after transient middle cerebral artery occlusion under warfarin anticoagulation in mice Peer-reviewed

Akira Ito, Kuniyasu Niizuma, Hiroaki Shimizu, Miki Fujimura, Keiji Hasumi, Teiji Tominaga

BRAIN RESEARCH　1578　38-48　2014/08

DOI： 10.1016/j.brainres.2014.07.004 　

ISSN： 0006-8993

eISSN： 1872-6240
Moyamoya syndrome associated with Basal meningioma successfully treated by the modified transsphenoidal approach: case report. Peer-reviewed

Ogawa Y, Fujimura M, Tominaga T

Journal of neurological surgery reports　75　(1)　e77-80　2014/08

DOI： 10.1055/s-0033-1363504 　

ISSN： 2193-6358
RBPJ is disrupted in a case of proximal 4p deletion syndrome with epilepsy Peer-reviewed

Tojo Nakayama, Hirotomo Saitsu, Wakaba Endo, Atsuo Kikuchi, Mitsugu Uematsu, Kazuhiro Haginoya, Naomi Hino-fukuyo, Tomoko Kobayashi, Masaki Iwasaki, Teiji Tominaga, Shigeo Kure, Naomichi Matsumoto

BRAIN & DEVELOPMENT　36　(6)　532-536　2014/06

DOI： 10.1016/j.braindev.2013.07.009 　

ISSN： 0387-7604

eISSN： 1872-7131
Mutually exclusive mutations of KIT and RAS are associated with KIT mRNA expression and chromosomal instability in primary intracranial pure germinomas Peer-reviewed

Shintaro Fukushima, Ayaka Otsuka, Tomonari Suzuki, Takaaki Yanagisawa, Kazuhiko Mishima, Akitake Mukasa, Nobuhito Saito, Toshihiro Kumabe, Masayuki Kanamori, Teiji Tominaga, Yoshitaka Narita, Soichiro Shibui, Mamoru Kato, Tatsuhiro Shibata, Masao Matsutani, Ryo Nishikawa, Koichi Ichimura

ACTA NEUROPATHOLOGICA　127　(6)　911-925　2014/06

DOI： 10.1007/s00401-014-1247-5 　

ISSN： 0001-6322

eISSN： 1432-0533
Development of a de novo arteriovenous malformation after bilateral revascularization surgery in a child with moyamoya disease Case report Peer-reviewed

Miki Fujimura, Naoto Kimura, Masayuki Ezura, Kuniyasu Niizuma, Hiroshi Uenohara, Tem Tominaga

JOURNAL OF NEUROSURGERY-PEDIATRICS　13　(6)　647-649　2014/06

DOI： 10.3171/2014.3.PEDS13610 　

ISSN： 1933-0707

eISSN： 1933-0715
Rapid and sensitive intraoperative detection of mutations in the isocitrate dehydrogenase 1 and 2 genes during surgery for glioma Laboratory investigation Peer-reviewed

Masayuki Kanamori, Atsuo Kikuchi, Mika Watanabe, Ichiyo Shibahara, Ryuta Saito, Yoji Yamashita, Yukihiko Sonoda, Toshihiro Kumabe, Shigeo Kure, Teiji Tominaga

JOURNAL OF NEUROSURGERY　120　(6)　1288-1297　2014/06

DOI： 10.3171/2014.3.JNS131505 　

ISSN： 0022-3085

eISSN： 1933-0693
Recurrent Extracranial Internal Carotid Artery Vasospasm Diagnosed by Serial Magnetic Resonance Angiography and Superselective Transarterial Injection of a Calcium Channel Blocker Peer-reviewed

Yoshiteru Shimoda, Miki Fujimura, Naoto Kimura, Masayuki Ezura, Hiroshi Uenohara, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　23　(5)　E383-E387　2014/05

DOI： 10.1016/j.jstrokecerebrovasdis.2013.12.050 　

ISSN： 1052-3057

eISSN： 1532-8511
Effects of Extracranial-Intracranial Bypass for Patients With Hemorrhagic Moyamoya Disease Results of the Japan Adult Moyamoya Trial Peer-reviewed

Susumu Miyamoto, Takashi Yoshimoto, Nobuo Hashimoto, Yasushi Okada, Ichiro Tsuji, Teiji Tominaga, Jyoji Nakagawara, Jun C. Takahashi

STROKE　45　(5)　1415-1421　2014/05

DOI： 10.1161/STROKEAHA.113.004386 　

ISSN： 0039-2499

eISSN： 1524-4628
Genetics and Biomarkers of Moyamoya Disease: Significance of RNF213 as a Susceptibility Gene Peer-reviewed

Miki Fujimura, Shinya Sonobe, Yasuo Nishijima, Kuniyasu Niizuma, Hiroyuki Sakata, Shigeo Kure, Teiji Tominaga

JOURNAL OF STROKE　16　(2)　65-72　2014/05

DOI： 10.5853/jos.2014.16.2.65 　

ISSN： 2287-6391

eISSN： 2287-6405
Transformation of adult cerebellar pilocytic astrocytoma to glioblastoma Peer-reviewed

Takashi Sasaki, Ryuta Saito, Toshihiro Kumabe, Masayuki Kanamori, Yukihiko Sonoda, Mika Watanabe, Teiji Tominaga

BRAIN TUMOR PATHOLOGY　31　(2)　108-112　2014/04

DOI： 10.1007/s10014-013-0154-0 　

ISSN： 1433-7398

eISSN： 1861-387X
Preservation of the Long Insular Artery to Prevent Postoperative Motor Deficits after Resection of Insulo-opercular Glioma: Technical Case Reports Peer-reviewed

Masaki Iwasaki, Toshihiro Kumabe, Ryuta Saito, Masayuki Kanamori, Yoji Yamashita, Yukihiko Sonoda, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　54　(4)　321-326　2014/04

DOI： 10.2176/nmc.cr2012-0361 　

ISSN： 0470-8105

eISSN： 1349-8029
A Multicenter Phase I/II Study of the BCNU Implant (Gliadel (R) Wafer) for Japanese Patients with Malignant Gliomas Peer-reviewed

Tomokazu Aoki, Ryo Nishikawa, Kazuhiko Sugiyama, Naosuke Nonoguchi, Noriyuki Kawabata, Kazuhiko Mishima, Jun-ichi Adachi, Kaoru Kurisu, Fumiyuki Yamasaki, Teiji Tominaga, Toshihiro Kumabe, Keisuke Ueki, Fumi Higuchi, Tetsuya Yamamoto, Eiichi Ishikawa, Hideo Takeshima, Shinji Yamashita, Kazunori Arita, Hirofumi Hirano, Shinobu Yamada, Masao Matsutani

NEUROLOGIA MEDICO-CHIRURGICA　54　(4)　290-301　2014/04

DOI： 10.2176/nmc.oa2013-0112 　

ISSN： 0470-8105

eISSN： 1349-8029
The Association of Subventricular Zone Involvement at Recurrence with Survival after Repeat Surgery in Patients with Recurrent Glioblastoma Peer-reviewed

Yukihiko Sonoda, Ryuta Saito, Masayuki Kanamori, Toshihiro Kumabe, Hiroshi Uenohara, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　54　(4)　302-309　2014/04

DOI： 10.2176/nmc.oa.2013-0226 　

ISSN： 0470-8105

eISSN： 1349-8029
A Multicenter Phase I/II Study of the BCNU Implant (Gliadel (R) Wafer) for Japanese Patients with Malignant Gliomas Peer-reviewed

Tomokazu Aoki, Ryo Nishikawa, Kazuhiko Sugiyama, Naosuke Nonoguchi, Noriyuki Kawabata, Kazuhiko Mishima, Jun-ichi Adachi, Kaoru Kurisu, Fumiyuki Yamasaki, Teiji Tominaga, Toshihiro Kumabe, Keisuke Ueki, Fumi Higuchi, Tetsuya Yamamoto, Eiichi Ishikawa, Hideo Takeshima, Shinji Yamashita, Kazunori Arita, Hirofumi Hirano, Shinobu Yamada, Masao Matsutani

NEUROLOGIA MEDICO-CHIRURGICA　54　(4)　290-301　2014/04

DOI： 10.2176/nmc.oa2013-0112 　

ISSN： 0470-8105

eISSN： 1349-8029
Spinal dural arteriovenous shunt presenting with intramedullary hemorrhage Peer-reviewed

Ayumi Narisawa, Toshiki Endo, Kenichi Sato, Mika Watanabe, Akira Takahashi, Teiji Tominaga

JOURNAL OF NEUROSURGERY-SPINE　20　(3)　322-326　2014/03

DOI： 10.3171/2013.12.SPINE12163 　

ISSN： 1547-5654

eISSN： 1547-5646
Temporal profile of the vascular anatomy evaluated by 9.4-T magnetic resonance angiography and histopathological analysis in mice lacking RNF213: A susceptibility gene for moyamoya disease Peer-reviewed

Shinya Sonobe, Miki Fujimura, Kuniyasu Niizuma, Yasuo Nishijima, Akira Ito, Hiroaki Shimizu, Atsuo Kikuchi, Natsuko Arai-Ichinoi, Shigeo Kure, Teiji Tominaga

BRAIN RESEARCH　1552　64-71　2014/03

DOI： 10.1016/j.brainres.2014.01.011 　

ISSN： 0006-8993

eISSN： 1872-6240
Cytogenetic Prognostication Within Medulloblastoma Subgroups Peer-reviewed

David J. H. Shih, Paul A. Northcott, Marc Remke, Andrey Korshunov, Vijay Ramaswamy, Marcel Kool, Betty Luu, Yuan Yao, Xin Wang, Adrian M. Dubuc, Livia Garzia, John Peacock, Stephen C. Mack, Xiaochong Wu, Adi Rolider, A. Sorana Morrissy, Florence M. G. Cavalli, David T. W. Jones, Karel Zitterbart, Claudia C. Faria, Ulrich Schueller, Leos Kren, Toshihiro Kumabe, Teiji Tominaga, Young Shin Ra, Miklos Garami, Peter Hauser, Jennifer A. Chan, Shenandoah Robinson, Laszlo Bognar, Almos Klekner, Ali G. Saad, Linda M. Liau, Steffen Albrecht, Adam Fontebasso, Giuseppe Cinalli, Pasqualino De Antonellis, Massimo Zollo, Michael K. Cooper, Reid C. Thompson, Simon Bailey, Janet C. Lindsey, Concezio Di Rocco, Luca Massimi, Erna M. C. Michiels, Stephen W. Scherer, Joanna J. Phillips, Nalin Gupta, Xing Fan, Karin M. Muraszko, Rajeev Vibhakar, Charles G. Eberhart, Maryam Fouladi, Boleslaw Lach, Shin Jung, Robert J. Wechsler-Reya, Michelle Fevre-Montange, Anne Jouvet, Nada Jabado, Ian F. Pollack, William A. Weiss, Ji-Yeoun Lee, Byung-Kyu Cho, Seung-Ki Kim, Kyu-Chang Wang, Jeffrey R. Leonard, Joshua B. Rubin, Carmen de Torres, Cinzia Lavarino, Jaume Mora, Yoon-Jae Cho, Uri Tabori, James M. Olson, Amar Gajjar, Roger J. Packer, Stefan Rutkowski, Scott L. Pomeroy, Pim J. French, Nanne K. Kloosterhof, Johan M. Kros, Erwin G. Van Meir, Steven C. Clifford, Franck Bourdeaut, Olivier Delattre, Francois F. Doz, Cynthia E. Hawkins, David Malkin, Wieslawa A. Grajkowska, Marta Perek-Polnik, Eric Bouffet, James T. Rutka, Stefan M. Pfister, Michael D. Taylor

JOURNAL OF CLINICAL ONCOLOGY　32　(9)　886-+　2014/03

DOI： 10.1200/JCO.2013.50.9539 　

ISSN： 0732-183X

eISSN： 1527-7755
A Prospective, Multicenter, Randomized Study of the Efficacy of Eicosapentaenoic Acid for Cerebral Vasospasm: The EVAS Study Peer-reviewed

Hiroshi Yoneda, Satoshi Shirao, Jyoji Nakagawara, Kuniaki Ogasawara, Teiji Tominaga, Michiyasu Suzuki

WORLD NEUROSURGERY　81　(2)　309-315　2014/02

DOI： 10.1016/j.wneu.2012.09.020 　

ISSN： 1878-8750

eISSN： 1878-8769
Minocycline Prevents Focal Neurological Deterioration Due to Cerebral Hyperperfusion After Extracranial-Intracranial Bypass for Moyamoya Disease Peer-reviewed

Miki Fujimura, Kuniyasu Niizuma, Takashi Inoue, Kenichi Sato, Hidenori Endo, Hiroaki Shimizu, Teiji Tominaga

NEUROSURGERY　74　(2)　163-170　2014/02

DOI： 10.1227/NEU.0000000000000238 　

ISSN： 0148-396X

eISSN： 1524-4040
A Ruptured Aneurysm Arising at the Leptomeningeal Collateral Circulation from the Extracranial Vertebral Artery to the Posterior Inferior Cerebellar Artery Associated with Bilateral Vertebral Artery Occlusion Peer-reviewed

Masashi Chonan, Shinjitu Nishimura, Naoto Kimura, Masayuki Ezura, Hiroshi Uenohara, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　23　(2)　E135-E139　2014/02

DOI： 10.1016/j.jstrokecerebrovasdis.2013.08.028 　

ISSN： 1052-3057

eISSN： 1532-8511
Cognard type V intracranial dural arteriovenous shunt: case reports and literature review with special consideration of the pattern of spinal venous drainage. Peer-reviewed

Haryu S, Endo T, Sato K, Inoue T, Takahashi A, Tominaga T

Neurosurgery　74　(1)　E135-42; discussion E142　2014/01

DOI： 10.1227/NEU.0000000000000069 　

ISSN： 0148-396X
Angiographic circulation time and cerebral blood flow during balloon test occlusion of the internal carotid artery Peer-reviewed

Kenichi Sato, Hiroaki Shimizu, Takashi Inoue, Miki Fujimura, Yasushi Matsumoto, Ryushi Kondo, Hidenori Endo, Yukihiko Sonoda, Teiji Tominaga

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　34　(1)　136-143　2014/01

DOI： 10.1038/jcbfm.2013.176 　

ISSN： 0271-678X

eISSN： 1559-7016
Treatment outcomes in glioblastoma patients aged 76 years or older: a multicenter retrospective cohort study Peer-reviewed

Takeo Uzuka, Kenichiro Asano, Toshio Sasajima, Kaori Sakurada, Toshihiro Kumabe, Takaaki Beppu, Masahiro Ichikawa, Chifumi Kitanaka, Hiroshi Aoki, Kiyoshi Saito, Kuniaki Ogasawara, Teiji Tominaga, Kazuo Mizoi, Hiroki Ohkuma, Yukihiko Fujii, Takamasa Kayama

JOURNAL OF NEURO-ONCOLOGY　116　(2)　299-306　2014/01

DOI： 10.1007/s11060-013-1291-3 　

ISSN： 0167-594X

eISSN： 1573-7373
Early response to chemotherapy as an indicator for the management of germinoma-like tumors of the pineal and/or suprasellar regions Peer-reviewed

Ryuta Saito, Toshihiro Kumabe, Masayuki Kanamori, Yukihiko Sonoda, Mika Watanabe, Shunji Mugikura, Shoki Takahashi, Teiji Tominaga

JOURNAL OF CLINICAL NEUROSCIENCE　21　(1)　124-130　2014/01

DOI： 10.1016/j.jocn.2013.05.014 　

ISSN： 0967-5868

eISSN： 1532-2653
Concentration rather than dose defines the local brain toxicity of agents that are effectively distributed by convection-enhanced delivery Peer-reviewed

Rong Zhang, Ryuta Saito, Yui Mano, Masayuki Kanamori, Yukihiko Sonoda, Toshihiro Kumabe, Teiji Tominaga

JOURNAL OF NEUROSCIENCE METHODS　222　131-137　2014/01

DOI： 10.1016/j.jneumeth.2013.11.004 　

ISSN： 0165-0270

eISSN： 1872-678X
Reliability of telecommunications systems following a major disaster: Survey of secondary and tertiary emergency institutions in miyagi prefecture during the acute phase of the 2011 Great East Japan Earthquake Peer-reviewed

Daisuke Kudo, Hajime Furukawa, Atsuhiro Nakagawa, Yoshiko Abe, Toshikatsu Washio, Tatsuhiko Arafune, Dai Sato, Satoshi Yamanouchi, Sae Ochi, Teiji Tominaga, Shigeki Kushimoto

Prehospital and Disaster Medicine　29　(2)　204-208　2014
Publisher: Cambridge University Press
DOI： 10.1017/S1049023X14000119 　

ISSN： 1945-1938 1049-023X

eISSN： 1945-1938
Post-purchase reassessment and improvement of neuroendoscope holder: Importance of physician-manufacturer communication Peer-reviewed

Yoshikazu Ogawa, Yusuke Nakata, Teiji Tominaga

TECHNOLOGY AND HEALTH CARE　22　(2)　297-301　2014

DOI： 10.3233/THC-140781 　

ISSN： 0928-7329

eISSN： 1878-7401
Hyponatremia caused by siadh following endoscopic third ventriculostomy: A case report Peer-reviewed

Ryota Shigeeda, Hidenori Endo, Miki Fujimura, Yoshikazu Ogawa, Hiroaki Shimizu, Teiji Tominaga

Neurological Surgery　42　(4)　335-339　2014
Publisher: Igaku-Shoin Ltd
ISSN： 1882-1251 0301-2603

eISSN： 1882-1251
Cardiopulmonary complication as a pitfall of the perioperative management of moyamoya syndrome with atherosclerosis: Conflict to counteract with cerebral hyperperfusion Peer-reviewed

Hiroyuki Sakata, Miki Fujimura, Kenichi Sato, Hiroaki Shimizu, Teiji Tominaga

Neurological Surgery　42　(8)　737-743　2014
Publisher: Igaku-Shoin Ltd
ISSN： 1882-1251 0301-2603

eISSN： 1882-1251
The Dissection Profile and Mechanism of Tissue-Selective Dissection of the Piezo Actuator-Driven Pulsed Water Jet as a Surgical Instrument: Laboratory Investigation Using Swine Liver Peer-reviewed

Masato Yamada, Toru Nakano, Chiaki Sato, Atsuhiro Nakagawa, Fumiyoshi Fujishima, Naoki Kawagishi, Chikashi Nakanishi, Tadashi Sakurai, Go Miyata, Teiji Tominaga, Noriaki Ohuchi

EUROPEAN SURGICAL RESEARCH　53　(1-4)　61-72　2014

DOI： 10.1159/000365288 　

ISSN： 0014-312X

eISSN： 1421-9921
Autoimmune hypophysitis presenting with intracranial multi-organ involvement: Three case reports and review of the literature Peer-reviewed

Atsushi Kanoke, Yoshikazu Ogawa, Mika Watanabe, Toshihiro Kumabe, Teiji Tominaga

BMC Research Notes　6　(1)　560　2013/12/28

DOI： 10.1186/1756-0500-6-560 　

ISSN： 1756-0500
Compression neuropathy caused by cancer metastasis to the optic nerve canal Peer-reviewed

Hiroshi Tamai, Kazuyuki Ishida, Kensuke Murakami, Norio Narita, Teiji Tominaga, Nobuo Fuse

BMC Research Notes　6　(1)　546　2013/12/20

DOI： 10.1186/1756-0500-6-546 　

ISSN： 1756-0500
Surgical Treatment of Spinal Extradural Arteriovenous Fistula With Parenchymal Drainage: Report on 5 Cases Peer-reviewed

Kuniyasu Niizuma, Toshiki Endo, Kenichi Sato, Shihomi Takada, Takayuki Sugawara, Shigeki Mikawa, Teiji Tominaga

NEUROSURGERY　73　(2 Suppl Operative)　E287-E293　2013/12

DOI： 10.1227/NEU.0000000000000189 　

ISSN： 0148-396X

eISSN： 1524-4040
Signal changes on T2*-weighted magnetic resonance imaging from the acute to chronic phases in patients with subarachnoid hemorrhage Peer-reviewed

Takashi Inoue, Shihomi Takada, Hiroaki Shimizu, Kuniyasu Niizuma, Miki Fujimura, Kenichi Sato, Hidenori Endo, Teiji Tominaga

Cerebrovascular Diseases　36　(5-6)　421-429　2013/12

DOI： 10.1159/000355897 　

ISSN： 1015-9770 1421-9786

eISSN： 1421-9786
Successful treatment of suprasellar tumors associated with poor brain blood perfusion by severe intracranial arterial stenosis: Two case reports Peer-reviewed

Yoshikazu Ogawa, Teiji Tominaga

BMC Research Notes　6　(1)　499　2013/12/01

DOI： 10.1186/1756-0500-6-499 　

ISSN： 1756-0500
Efficacy of fusion image for the preoperative assessment of anatomical variation of the anterior choroidal artery Peer-reviewed

Yasuko Aoki, Hidenori Endo, Kuniyasu Nnzuma, Takashi Inoue, Hiroaki Shimizu, Teiji Tominaga

Neurological Surgery　41　(12)　1075-1080　2013/12

ISSN： 0301-2603 1882-1251

eISSN： 1882-1251
Time-varying inter-hemispheric coherence during corpus callosotomy Peer-reviewed

Eiichi Okumura, Masaki Iwasaki, Rie Sakuraba, Izumi Itabashi, Shin-ichiro Osawa, Kazutaka Jin, Hisashi Itabashi, Kazuhiro Kato, Akitake Kanno, Teiji Tominaga, Nobukazu Nakasato

CLINICAL NEUROPHYSIOLOGY　124　(11)　2091-2100　2013/11

DOI： 10.1016/j.clinph.2013.05.004 　

ISSN： 1388-2457

eISSN： 1872-8952
I-123-IMP-SPECT in a Patient with Cerebral Proliferative Angiopathy: A Case Report Peer-reviewed

Tomomi Kimiwada, Toshiaki Hayashi, Reizo Shirane, Teiji Tominaga

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　22　(8)　1432-1435　2013/11

DOI： 10.1016/j.jstrokecerebrovasdis.2013.05.038 　

ISSN： 1052-3057

eISSN： 1532-8511
Relative Residence Time Prolongation in Intracranial Aneurysms: A Possible Association With Atherosclerosis Peer-reviewed

Shin-ichiro Sugiyama, Kuniyasu Niizuma, Toshio Nakayama, Hiroaki Shimizu, Hidenori Endo, Takashi Inoue, Miki Fujimura, Makoto Ohta, Akira Takahashi, Teiji Tominaga

NEUROSURGERY　73　(5)　767-776　2013/11

DOI： 10.1227/NEU.0000000000000096 　

ISSN： 0148-396X

eISSN： 1524-4040
Treatment Results of Glioblastoma during the Last 30 Years in a Single Institute Peer-reviewed

Toshihiro Kumabe, Ryuta Saito, Masayuki Kanamori, Masashi Chonan, Yui Mano, Ichiyo Shibahara, Tomohiro Kawaguchi, Hideaki Kato, Yoji Yamashita, Yukihiko Sonoda, Jun Kawagishi, Hidefumi Jokura, Mika Watanabe, Ryuichi Katakura, Takamasa Kayama, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　53　(11)　786-796　2013/11

DOI： 10.2176/nmc.oa2013-0212 　

ISSN： 0470-8105

eISSN： 1349-8029
Computational simulation of convection-enhanced drug delivery in the non-human primate brainstem: a simple model predicting the drug distribution Peer-reviewed

Shin-ichiro Sugiyama, Ryuta Saito, Kenichi Funamoto, Toshio Nakayama, Yukihiko Sonoda, Yoji Yamashita, Tomoo Inoue, Toshihiro Kumabe, Toshiyuki Hayase, Teiji Tominaga

NEUROLOGICAL RESEARCH　35　(8)　773-781　2013/10

DOI： 10.1179/1743132813Y.0000000215 　

ISSN： 0161-6412
Tissue dissection before direct manipulation to the pathology with pulsed laser-induced liquid jet system in skull base surgery-preservation of fine vessels and maintained optic nerve function Peer-reviewed

Yoshikazu Ogawa, Atsuhiro Nakagawa, Toshikatsu Washio, Tatsuhiko Arafune, Teiji Tominaga

ACTA NEUROCHIRURGICA　155　(10)　1879-1886　2013/10

DOI： 10.1007/s00701-013-1817-7 　

ISSN： 0001-6268
Clinical significance and limitations of repeat resection for pediatric malignant neuroepithelial tumors Peer-reviewed

Tomohiro Kawaguchi, Toshihiro Kumabe, Ryuta Saito, Masayuki Kanamori, Yoji Yamashita, Yukihiko Sonoda, Teiji Tominaga

JOURNAL OF NEUROSURGERY-PEDIATRICS　12　(4)　309-316　2013/10

DOI： 10.3171/2013.6.PEDS12606 　

ISSN： 1933-0707
Resources for Business Continuity in Disaster-Based Hospitals in the Great East Japan Earthquake: Survey of Miyagi Prefecture Disaster Base Hospitals and the Prefectural Disaster Medicine Headquarters Peer-reviewed

Daisuke Kudo, Hajime Furukawa, Atsuhiro Nakagawa, Satoshi Yamanouchi, Yuichi Koido, Takashi Matsumura, Yoshiko Abe, Ryota Konishi, Masaaki Matoba, Teiji Tominaga, Shigeki Kushimoto

DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS　7　(5)　461-466　2013/10

DOI： 10.1017/dmp.2013.77 　

ISSN： 1935-7893

eISSN： 1938-744X
Transsphenoidal microsurgical results of female patients with prolactinomas Peer-reviewed

Hidetoshi Ikeda, Kazuo Watanabe, Teiji Tominaga, Takashi Yoshimoto

Clinical Neurology and Neurosurgery　115　(9)　1621-1625　2013/09

DOI： 10.1016/j.clineuro.2013.02.016 　

ISSN： 0303-8467 1872-6968
The expression status of CD133 is associated with the pattern and timing of primary glioblastoma recurrence. International-journal Peer-reviewed

Ichiyo Shibahara, Yukihiko Sonoda, Ryuta Saito, Masayuki Kanamori, Yoji Yamashita, Toshihiro Kumabe, Mika Watanabe, Hiroyoshi Suzuki, Takashi Watanabe, Chikashi Ishioka, Teiji Tominaga

Neuro-oncology　15　(9)　1151-9　2013/09

DOI： 10.1093/neuonc/not066 　

ISSN： 1522-8517

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BACKGROUND: Glioblastoma carries a poor prognosis primarily because of its high rate of recurrence. The ability to predict the recurrence pattern and timing would be highly useful for determining effective treatment strategies. We examined the correlation between prognostic factors and the pattern of recurrence in patients with primary glioblastoma. In particular, we examined whether there was a correlation between the expression of CD133 and glioblastoma recurrence. METHODS: We retrospectively analyzed 112 patients with primary glioblastoma. The timing and pattern (local or distant) of the initial recurrence were obtained from medical records. To identify factors predictive of recurrence, we examined CD133 expression by Western blots and immunohistochemistry, clinical (age, sex, KPS, Ki67 labeling index, surgery, ventricular entry) and genetic (IDH1, 7p, 9p, 10q, MGMT) factors. RESULTS: Of the 112 patients, 99 suffered recurrence. The first recurrence was local in 77 patients and distant in 22 patients. Among the factors to predict the pattern of recurrence, CD133 expression was significantly higher in distant than in local recurrence. Of the factors to predict the timing of recurrence, high CD133 expression was associated with shorter time to distant recurrence in both univariate and multivariate analyses (P = .0011 and P = .038, respectively). CONCLUSIONS: The expression of CD133 may be a predictor of the pattern and timing of recurrence of primary glioblastoma.
Medial posterior choroidal artery territory infarction associated with tumor removal in the pineal/tectum/thalamus region through the occipital transtentorial approach Peer-reviewed

Ryuta Saito, Toshihiro Kumabe, Masayuki Kanamori, Yukihiko Sonoda, Shunji Mugikura, Shoki Takahashi, Teiji Tominaga

CLINICAL NEUROLOGY AND NEUROSURGERY　115　(8)　1257-1263　2013/08

DOI： 10.1016/j.clineuro.2012.11.020 　

ISSN： 0303-8467
Moyamoya Disease in Pregnancy: A Single Institute Experience Peer-reviewed

Miki Fujimura, Kozo Akagi, Hiroshi Uenohara, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　53　(8)　561-564　2013/08

DOI： 10.2176/nmc.53.561 　

ISSN： 0470-8105
Clinical and histological characteristics of recurrent oligodendroglial tumors: comparison between primary and recurrent tumors in 18 cases Peer-reviewed

Masayuki Kanamori, Toshihiro Kumabe, Ichiyo Shibahara, Ryuta Saito, Yoji Yamashita, Yukihiko Sonoda, Hiroyoshi Suzuki, Mika Watanabe, Teiji Tominaga

BRAIN TUMOR PATHOLOGY　30　(3)　151-159　2013/07

DOI： 10.1007/s10014-012-0119-8 　

ISSN： 1433-7398
Infarction of the lateral posterior choroidal artery territory after manipulation of the choroid plexus at the atrium: causal association with subependymal artery injury. International-journal Peer-reviewed

Ryuta Saito, Toshihiro Kumabe, Yukihiko Sonoda, Masayuki Kanamori, Shunji Mugikura, Shoki Takahashi, Teiji Tominaga

Journal of neurosurgery　119　(1)　158-63　2013/07

DOI： 10.3171/2013.2.JNS121221 　

ISSN： 0022-3085

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OBJECT: The atrium of the lateral ventricle is often affected by tumors, and some patients with these tumors suffer neurological deficits, including hemiparesis after surgery. The authors of this study investigated the possible mechanisms causing the relatively high incidences of ischemic complications associated with surgery approaching the atrium of the lateral ventricle. METHODS: Clinical records and radiological images of 28 patients were retrospectively studied. These patients had their lateral ventricles opened at the atrium during the resection of gliomas as well as other nonbenign brain tumors, and were treated for gliomas at our tertiary referral center in the Tohoku district, Japan, between January 2008 and December 2010. RESULTS: Routine postoperative diffusion-weighted MR images obtained within 72 hours after surgery detected infarction in the periatrial/periventricular regions in 7 patients, presumably corresponding to the lateral posterior choroidal artery (LPChA) territory. Five of these 7 patients suffered neurological sequelae with varying severities. The choroid plexus at the atrium was coagulated to achieve hemostasis during the surgery in all of these patients. Detailed analysis of microangiograms revealed ventriculofugal arteries arising from the lateral ventricle. Damage of the subependymal artery that supplies the ventriculofugal arteries caused by coagulation of the choroid plexus at the atrium probably resulted in the infarction in these patients. CONCLUSIONS: Neurosurgeons must be aware of the possibility of LPChA territory infarction during surgery in the atrial or periatrial regions caused by subependymal artery obstruction after manipulating or coagulating the choroid plexus near the atrium.
Pilomyxoid astrocytoma of the cerebellum with Williams syndrome: a case report Peer-reviewed

Masashi Chonan, Masayuki Kanamori, Toshihiro Kumabe, Ryuta Saito, Mika Watanabe, Teiji Tominaga

CHILDS NERVOUS SYSTEM　29　(7)　1211-1214　2013/07

DOI： 10.1007/s00381-013-2107-7 　

ISSN： 0256-7040
Risk Assessment for Venous Thromboembolism in Patients With Neuroepithelial Tumors: Pretreatment Score to Identify High Risk Patients Peer-reviewed

Tomohiro Kawaguchi, Toshihiro Kumabe, Masayuki Kanamori, Ryuta Saito, Yoji Yamashita, Yukihiko Sonoda, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　53　(7)　467-473　2013/07

DOI： 10.2176/nmc.53.467 　

ISSN： 0470-8105

eISSN： 1349-8029
Quantitative assessment of cerebral hemodynamics using single photon emission computed tomography with venous blood sampling Peer-reviewed

Takashi Inoue, Miki Fujimura, Hiroaki Shimizu, Yoshitake Takahashi, Teiji Tominaga

CLINICAL NEUROLOGY AND NEUROSURGERY　115　(6)　684-689　2013/06

DOI： 10.1016/j.clineuro.2012.08.020 　

ISSN： 0303-8467
5-aminolevulinic acid fluorescence-guided resection of intramedullary ependymoma: Report of 9 cases Peer-reviewed

Tomoo Inoue, Toshiki Endo, Kenichi Nagamatsu, Mika Watanabe, Teiji Tominaga

Neurosurgery　72　(2 Suppl Operative)　ons159-ons168　2013/06

DOI： 10.1227/NEU.0b013e31827bc7a3 　

ISSN： 0148-396X
Rathke's cleft cysts with significant squamous metaplasia-high risk of postoperative deterioration and close origins to craniopharyngioma Peer-reviewed

Yoshikazu Ogawa, Mika Watanabe, Teiji Tominaga

ACTA NEUROCHIRURGICA　155　(6)　1069-1075　2013/06

DOI： 10.1007/s00701-012-1593-9 　

ISSN： 0001-6268
[I. Convection-enhanced delivery for treatment of glioma]. Peer-reviewed

Saito R, Tominaga T

Gan to kagaku ryoho. Cancer & chemotherapy　40　(6)　705-707　2013/06

ISSN： 0385-0684
Experimental application of pulsed laser-induced water jet for endoscopic submucosal dissection: Mechanical investigation and preliminary experiment in swine Peer-reviewed

Chiaki Sato, Toru Nakano, Atsuhiro Nakagawa, Masato Yamada, Hiroaki Yamamoto, Takashi Kamei, Go Miyata, Akira Sato, Fumiyoshi Fujishima, Masaaki Nakai, Mitsuo Niinomi, Kazuyoshi Takayama, Teiji Tominaga, Susumu Satomi

DIGESTIVE ENDOSCOPY　25　(3)　255-263　2013/05

DOI： 10.1111/j.1443-1661.2012.01375.x 　

ISSN： 0915-5635
Parental satisfaction and seizure outcome after corpus callosotomy in patients with infantile or early childhood onset epilepsy Peer-reviewed

Masaki Iwasaki, Mitsugu Uematsu, Tojo Nakayama, Naomi Hino-Fukuyo, Yuko Sato, Tomoko Kobayashi, Kazuhiro Haginoya, Shin-ichiro Osawa, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY　22　(4)　303-305　2013/05

DOI： 10.1016/j.seizure.2013.01.005 　

ISSN： 1059-1311
Dynamic changes in magnetic resonance imaging appearance of dysembryoplastic neuroepithelial tumor with or without malignant transformation Report of 2 cases Peer-reviewed

Yui Mano, Toshihiro Kumabe, Ichiyo Shibahara, Ryuta Saito, Yukihiko Sonoda, Mika Watanabe, Teiji Tominaga

JOURNAL OF NEUROSURGERY-PEDIATRICS　11　(5)　518-525　2013/05

DOI： 10.3171/2013.1.PEDS11449 　

ISSN： 1933-0707

eISSN： 1933-0715
Use of microscope-integrated near-infrared indocyanine green videoangiography in the surgical treatment of intramedullary cavernous malformations: report of 8 cases Peer-reviewed

Toshiki Endo, Misaki Aizawa-Kohama, Kenichi Nagamatsu, Kensuke Murakami, Akira Takahashi, Teiji Tominaga

JOURNAL OF NEUROSURGERY-SPINE　18　(5)　443-449　2013/05

DOI： 10.3171/2013.1.SPINE12482 　

ISSN： 1547-5654
Cilostazol for the Prevention of Acute Progressing Stroke: A Multicenter, Randomized Controlled Trial Peer-reviewed

Hiroaki Shimizu, Teiji Tominaga, Akira Ogawa, Takamasa Kayama, Kazuo Mizoi, Kiyoshi Saito, Yasuo Terayama, Kuniaki Ogasawara, Etsuro Mori

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　22　(4)　449-456　2013/05

DOI： 10.1016/j.jstrokecerebrovasdis.2013.02.009 　

ISSN： 1052-3057
[A primary epileptogenic tuber revealed after corpus callosotomy in a patient with tuberous sclerosis complex and multiple tubers]. Peer-reviewed

Keisuke Sato, Masaki Iwasaki, Mitsugu Uematsu, Nobukazu Nakasato, Teiji Tominaga

No shinkei geka. Neurological surgery　41　(5)　421-8　2013/05

ISSN： 0301-2603

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Identification of primary epileptogenic tuber is often challenging in patients with bilateral multiple tubers in tuberous sclerosis complex. We report a 3 year old girl with tuberous sclerosis complex presenting with intractable epilepsy and multiple tubers, who was successfully treated by corpus callosotomy and subsequent resective surgery. She initially presented with West syndrome which was intractable to ACTH therapy and multiple antiepileptic medications. Her EEG was characterized by generalized and multifocal spikes, and by non-focal changes at seizure onset. Ictal single photon emission computed tomography(SPECT)showed no focal hyperperfusion. Total corpus callosotomy was performed to alleviate her drop attacks. Post-operatively, interictal spikes were completely lateralized to the right hemisphere. Since her seizures were still kept uncontrolled with medications, second pre-surgical evaluation was planned and ictal SPECT disclosed focal hyperperfusion at a tuber in the right frontal lobe. After complete resection of the right frontal tuber, she was completely seizure free on antiepileptic medications for 1 year with no additional neurological deficits. Generalized or multifocal electroencephalographic(EEG)spikes are occasionally lateralized to one hemisphere after corpus callosotomy, which may help identifying the primary epileptogenic focus. Repeat pre-surgical evaluation is important after corpus callosotomy in patients with generalized or multifocal epileptiforms in EEG.
The great East Japan earthquake: lessons learned at Tohoku University Hospital during the first 72 hours. Peer-reviewed

Nakagawa A, Furukawa H, Konishi R, Kudo D, Matsumura T, Sato D, Abe Y, Washio T, Arafune T, Yamanouchi S, Kushimoto S, Tominaga T

IEEE pulse　4　(3)　20-27　2013/05

DOI： 10.1109/MPUL.2013.2250851 　

ISSN： 2154-2287
Malignant pediatric brain tumor of primitive small round cell proliferation with bland-looking mesenchymal spindle cell elements Peer-reviewed

Akira Ito, Toshihiro Kumabe, Ryuta Saito, Yukihiko Sonoda, Mika Watanabe, Yoichi Nakazato, Teiji Tominaga

BRAIN TUMOR PATHOLOGY　30　(2)　109-116　2013/04

DOI： 10.1007/s10014-012-0106-0 　

ISSN： 1433-7398
Noninvasive measurement of human brain temperature adjacent to arteriovenous malformation using 3.0 T magnetic resonance spectroscopy Peer-reviewed

Takashi Inoue, Hiroaki Shimizu, Miki Fujimura, Atsushi Saito, Yoshichika Yoshioka, Tsuyoshi Matsuda, Teiji Tominaga

CLINICAL NEUROLOGY AND NEUROSURGERY　115　(4)　445-449　2013/04

DOI： 10.1016/j.clineuro.2012.06.022 　

ISSN： 0303-8467
Metachronous, multicentric glioma of pilocytic astrocytoma with oligodendroglioma-like component and oligodendroglioma through distinct genetic aberrations Case report Peer-reviewed

Atsushi Kanoke, Masayuki Kanamori, Toshihiro Kumabe, Ryuta Saito, Mika Watanabe, Teiji Tominaga

JOURNAL OF NEUROSURGERY　118　(4)　854-858　2013/04

DOI： 10.3171/2012.9.JNS112353 　

ISSN： 0022-3085
Increase in the number of patients with seizures following the Great East-Japan Earthquake. International-journal Peer-reviewed

Ichiyo Shibahara, Shin-Ichiro Osawa, Hiroyuki Kon, Takahiro Morita, Nobukazu Nakasato, Teiji Tominaga, Norio Narita

Epilepsia　54　(4)　e49-52-52　2013/04

DOI： 10.1111/epi.12070 　

ISSN： 0013-9580

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In the afternoon of March 11, 2011, Kesennuma City was hit by the Great East-Japan Earthquake and a devastating tsunami. The purpose of this retrospective study is to document possible changes in the number of patients with distinct neurologic diseases seeking treatment following this disaster. Because of Kesennuma's unique geographical location, the city was isolated by the disaster, allowing for a study with relatively limited population selection bias. Patients admitted for neurologic emergencies from January 14 to May 5 in 2011 (n = 117) were compared with patients in the corresponding 16-week periods in 2008-2010 (n = 323). The number of patients with unprovoked seizures was significantly higher during the 8-week period after the earthquake (n = 13) than during the same periods in 2008 (n = 6), 2009 (n = 3), and 2010 (no patients) (p = 0.0062). In contrast, the number of patients treated for other neurologic diseases such as stroke, trauma, and tumors remained unchanged. To our knowledge, this is the first report of an increase in the number of patients with seizures following a life-threatening natural disaster. We suggest that stress associated with life-threatening situations may enhance seizure generation.
Optogenetically Induced Seizure and the Longitudinal Hippocampal Network Dynamics Peer-reviewed

Shin-ichiro Osawa, Masaki Iwasaki, Ryosuke Hosaka, Yoshiya Matsuzaka, Hiroshi Tomita, Toru Ishizuka, Eriko Sugano, Eiichi Okumura, Hiromu Yawo, Nobukazu Nakasato, Teiji Tominaga, Hajime Mushiake

PLOS ONE　8　(4)　e60928　2013/04

DOI： 10.1371/journal.pone.0060928 　

ISSN： 1932-6203
Surgical indication and outcome in patients with postoperative retethered cord syndrome Clinical article Peer-reviewed

Toshiaki Hayashi, Jun Takemoto, Tatschiro Ochiai, Tomomi Kimiwada, Reizo Shirane, Kiyohide Sakai, Haruo Nakagawa, Teiji Tominaga

JOURNAL OF NEUROSURGERY-PEDIATRICS　11　(2)　133-139　2013/02

DOI： 10.3171/2012.10.PEDS12220 　

ISSN： 1933-0707

eISSN： 1933-0715
Concurrent dural and perimedullary arteriovenous fistulas at the craniocervical junction: Case series with special reference to angioarchitecture ; Clinical article Peer-reviewed

Kenichi Sato, Toshiki Endo, Kuniyasu Niizuma, Miki Fujimura, Takashi Inoue, Hiroaki Shimizu, Teiji Tominaga

Journal of Neurosurgery　118　(2)　451-459　2013/02

DOI： 10.3171/2012.10.JNS121028 　

ISSN： 0022-3085 1933-0693

eISSN： 1933-0693
Randomized trial of chemoradiotherapy and adjuvant chemotherapy with nimustine (ACNU) versus nimustine plus procarbazine for newly diagnosed anaplastic astrocytoma and glioblastoma (JCOG0305) Peer-reviewed

Soichiro Shibui, Yoshitaka Narita, Junki Mizusawa, Takaaki Beppu, Kuniaki Ogasawara, Yutaka Sawamura, Hiroyuki Kobayashi, Ryo Nishikawa, Kazuhiko Mishima, Yoshihiro Muragaki, Takashi Maruyama, Junichi Kuratsu, Hideo Nakamura, Masato Kochi, Yoshio Minamida, Toshiaki Yamaki, Toshihiro Kumabe, Teiji Tominaga, Takamasa Kayama, Kaori Sakurada, Motoo Nagane, Keiichi Kobayashi, Hirohiko Nakamura, Tamio Ito, Takahito Yazaki, Hikaru Sasaki, Katsuyuki Tanaka, Hideaki Takahashi, Akio Asai, Tomoki Todo, Toshihiko Wakabayashi, Jun Takahashi, Shingo Takano, Takamitsu Fujimaki, Minako Sumi, Yasuji Miyakita, Yoichi Nakazato, Akihiro Sato, Haruhiko Fukuda, Kazuhiro Nomura

Cancer Chemotherapy and Pharmacology　71　(2)　511-521　2013/02

DOI： 10.1007/s00280-012-2041-5 　

ISSN： 0344-5704 1432-0843
Clinicopathological analysis of nine consecutive central nervous system primitive neuroectodermal tumors in a single institute Peer-reviewed

Misaki Aizawa-Kohama, Toshihiro Kumabe, Ryuta Saito, Masayuki Kanamori, Yoji Yamashita, Yukihiko Sonoda, Mika Watanabe, Teiji Tominaga

BRAIN TUMOR PATHOLOGY　30　(1)　15-27　2013/01

DOI： 10.1007/s10014-012-0097-x 　

ISSN： 1433-7398
Medullary infarction as a poor prognostic factor after internal coil trapping of a ruptured vertebral artery dissection Clinical article Peer-reviewed

Hidenori Endo, Yasushi Matsumoto, Ryushi Kondo, Kenichi Sato, Miki Fujimura, Takashi Inoue, Hiroaki Shimizu, Akira Takahashi, Teiji Tominaga

JOURNAL OF NEUROSURGERY　118　(1)　131-139　2013/01

DOI： 10.3171/2012.9.JNS12566 　

ISSN： 0022-3085
Transplantation of bone marrow stromal cell-derived neural precursor cells ameliorates deficits in a rat model of complete spinal cord transection. International-journal Peer-reviewed

Misaki Aizawa-Kohama, Toshiki Endo, Masaaki Kitada, Shohei Wakao, Akira Sumiyoshi, Dai Matsuse, Yasumasa Kuroda, Takahiro Morita, Jorge J Riera, Ryuta Kawashima, Teiji Tominaga, Mari Dezawa

Cell transplantation　22　(9)　1613-25　2013

DOI： 10.3727/096368912X658791 　

ISSN： 0963-6897

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After severe spinal cord injury, spontaneous functional recovery is limited. Numerous studies have demonstrated cell transplantation as a reliable therapeutic approach. However, it remains unknown whether grafted neuronal cells could replace lost neurons and reconstruct neuronal networks in the injured spinal cord. To address this issue, we transplanted bone marrow stromal cell-derived neural progenitor cells (BM-NPCs) in a rat model of complete spinal cord transection 9 days after the injury. BM-NPCs were induced from bone marrow stromal cells (BMSCs) by gene transfer of the Notch-1 intracellular domain followed by culturing in the neurosphere method. As reported previously, BM-NPCs differentiated into neuronal cells in a highly selective manner in vitro. We assessed hind limb movements of the animals weekly for 7 weeks to monitor functional recovery after local injection of BM-NPCs to the transected site. To test the sensory recovery, we performed functional magnetic resonance imaging (fMRI) using electrical stimulation of the hind limbs. In the injured spinal cord, transplanted BM-NPCs were confirmed to express neuronal markers 7 weeks following the transplantation. Grafted cells successfully extended neurites beyond the transected portion of the spinal cord. Adjacent localization of synaptophysin and PSD-95 in the transplanted cells suggested synaptic formations. These results indicated survival and successful differentiation of BM-NPCs in the severely injured spinal cord. Importantly, rats that received BM-NPCs demonstrated significant motor recovery when compared to the vehicle injection group. Volumes of the fMRI signals in somatosensory cortex were larger in the BM-NPC-grafted animals. However, neuronal activity was diverse and not confined to the original hind limb territory in the somatosensory cortex. Therefore, reconstruction of neuronal networks was not clearly confirmed. Our results indicated BM-NPCs as an effective method to deliver neuronal lineage cells in a severely injured spinal cord. However, reestablishment of neuronal networks in completed transected spinal cord was still a challenging task.
Effect of Cilostazol in the Treatment of Acute Ischemic Stroke in the Lenticulostriate Artery Territory Peer-reviewed

Ryushi Kondo, Yasushi Matsumoto, Eisuke Furui, Ryo Itabashi, Shoichiro Sato, Yukako Yazawa, Hiroaki Shimizu, Satoru Fujiwara, Akira Takahashi, Teiji Tominaga

EUROPEAN NEUROLOGY　69　(2)　122-128　2013

DOI： 10.1159/000343799 　

ISSN： 0014-3022
Thyroid-stimulating hormone-secreting pituitary adenoma presenting with recurrent hyperthyroidism in post-treated Graves' disease: a case report. Peer-reviewed

Ogawa Y, Tominaga T

Journal of medical case reports　7　27　2013/01

DOI： 10.1186/1752-1947-7-27 　
Surgical treatment of scaphocephaly with sinus pericranii. Peer-reviewed

Kimiwada T, Hayashi T, Sanada T, Shirane R, Tominaga T

Neurologia medico-chirurgica　53　(2)　121-125　2013

DOI： 10.2176/nmc.53.121 　

ISSN： 0470-8105
Clinicopathological Investigation of Vascular Endothelial Growth Factor and von Hippel-Lindau Gene-Related Protein Expression in Immunohistochemically Negative Pituitary Adenoma - Possible Involvement in Tumor Aggressiveness Peer-reviewed

Yoshiteru Shimoda, Yoshikazu Ogawa, Mika Watanabe, Teiji Tominaga

ENDOCRINE RESEARCH　38　(4)　242-250　2013

DOI： 10.3109/07435800.2013.774411 　

ISSN： 0743-5800
Summary of 15 years experience of awake surgeries for neuroepithelial tumors in tohoku university. Peer-reviewed

Toshihiro Kumabe, Kiyotaka Sato, Masaki Iwasaki, Ichiyo Shibahara, Tomohiro Kawaguchi, Ryuta Saito, Masayuki Kanamori, Yoji Yamashita, Yukihiko Sonoda, Osamu Iizuka, Kyoko Suzuki, Ken-Ichi Nagamatsu, Shintaro Seki, Nobukazu Nakasato, Teiji Tominaga

Neurologia medico-chirurgica　53　(7)　455-66　2013

DOI： 10.2176/nmc.53.455 　

ISSN： 0470-8105

eISSN： 1349-8029

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We retrospectively analyzed 15 years experience of awake surgeries for neuroepithelial tumors in Tohoku University. Awake surgeries mostly for language mapping were performed for 42 of 681 newly diagnosed cases (6.2%) and 59 of 985 surgeries including for recurrence (6.0%). When the same histologies and locations as cases resected under awake condition are selected from the parent population treated by radical resection, awake surgeries were most frequently performed for 14 of 55 newly diagnosed cases (25.5%) and 14 of 62 surgeries (22.6%) with grade II gliomas. In the results, 8 of 59 surgeries (13.6%) could not achieve complete language monitoring until the final stage of tumor resection, considered as failed awake surgery. Gross total resection was accomplished in 20 of 42 newly diagnosed cases (47.6%) and 32 of 59 surgeries (54.2%). Mortality rate was 0%. Late severe deficits were observed in 2 of 42 newly diagnosed cases (4.8%) and 3 of 59 surgeries (5.1%). Negative language mapping cases did not suffer severe deficits in both early and late stages. In contrast, high incidence of severe deficits, 3 as early and 2 as late of 8 cases, were identified with failed awake surgery. The overall survival of patients treated by awake surgery compared favorably with those treated without stimulation mapping and with stimulation mapping under general anesthesia. Awake surgery may contribute to improve the outcome of gliomas near eloquent areas by maximizing the tumor resection and minimizing the surgical morbidity.
Follicle-stimulating hormone-secreting pituitary adenoma manifesting as recurrent ovarian cysts in a young woman - Latent risk of unidentified ovarian hyperstimulation: A case report Peer-reviewed

Tomohiro Kawaguchi, Yoshikazu Ogawa, Kenji Ito, Mika Watanabe, Teiji Tominaga

BMC Research Notes　6　(1)　408　2013

DOI： 10.1186/1756-0500-6-408 　

ISSN： 1756-0500
IDH1/2 gene status defines the prognosis and molecular profiles in patients with grade III gliomas Peer-reviewed

Ichiyo Shibahara, Yukihiko Sonoda, Masayuki Kanamori, Ryuta Saito, Yoji Yamashita, Toshihiro Kumabe, Mika Watanabe, Hiroyoshi Suzuki, Shunsuke Kato, Chikashi Ishioka, Teiji Tominaga

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY　17　(6)　551-561　2012/12

DOI： 10.1007/s10147-011-0323-2 　

ISSN： 1341-9625
A case of moyamoya disease presenting with progressive stroke during the late perinatal period successfully managed by bilateral revascularization surgeries Peer-reviewed

Takashi Sasaki, Miki Fujimura, Yosuke Akamatsu, Naoto Kimura, Masayuki Ezura, Hiroshi Uenohara, Kozo Akagi, Teiji Tominaga

Neurological Surgery　40　(12)　1095-1099　2012/12

ISSN： 0301-2603 1882-1251
Required knowledge for neuroendovascular surgeon (4) basic technique of the coil embolization and parent artery occlusion for cerebral aneurysms Peer-reviewed

Hidenori Endo, Yasushi Matsumoto, Ryushi Kondo, Ichiro Suzuki, Toshio Kikuchi, Teiji Tominaga

Neurological Surgery　40　(12)　1107-1118　2012/12

ISSN： 0301-2603 1882-1251
Hemodynamic Analysis of Growing Intracranial Aneurysms Arising from a Posterior Inferior Cerebellar Artery Peer-reviewed

Shin-Ichiro Sugiyama, Hui Meng, Kenichi Funamoto, Takashi Inoue, Miki Fujimura, Toshio Nakayama, Shunsuke Omodaka, Hiroaki Shimizu, Akira Takahashi, Teiji Tominaga

WORLD NEUROSURGERY　78　(5)　462-468　2012/11

DOI： 10.1016/j.wneu.2011.09.023 　

ISSN： 1878-8750
Childhood transverse sinus dural arteriovenous fistula treated with endovascular and direct surgery: A case report Peer-reviewed

Kuniyasu Niizuma, Hiroyuki Sakata, Shinya Koyama, Hiroyuki Kon, Masashi Chonan, Tatsuya Sasaki, Michiharu Nishijima, Masayuki Ezura, Teiji Tominaga

Neurological Surgery　40　(11)　1015-1020　2012/11

ISSN： 0301-2603 1882-1251
Influence of surface model extraction parameter on computational fluid dynamics modeling of cerebral aneurysms Peer-reviewed

Shunsuke Omodaka, Takashi Inoue, Kenichi Funamoto, Shin-ichirou Sugiyama, Hiroaki Shimizu, Toshiyuki Hayase, Akira Takahashi, Teiji Tominaga

JOURNAL OF BIOMECHANICS　45　(14)　2355-2361　2012/09

DOI： 10.1016/j.jbiomech.2012.07.006 　

ISSN： 0021-9290
[Case of chordoid glioma of the third ventricle]. Peer-reviewed

Ayumi Narisawa, Toshihiro Kumabe, Ryuta Saito, Yukihiko Sonoda, Mika Watanabe, Teiji Tominaga

No shinkei geka. Neurological surgery　40　(9)　805-11　2012/09

ISSN： 0301-2603
Subgroup-specific structural variation across 1,000 medulloblastoma genomes Peer-reviewed

Paul A. Northcott, David J. H. Shih, John Peacock, Livia Garzia, A. Sorana Morrissy, Thomas Zichner, Adrian M. Stuetz, Andrey Korshunov, Jueri Reimand, Steven E. Schumacher, Rameen Beroukhim, David W. Ellison, Christian R. Marshall, Anath C. Lionel, Stephen Mack, Adrian Dubuc, Yuan Yao, Vijay Ramaswamy, Betty Luu, Adi Rolider, Florence M. G. Cavalli, Xin Wang, Marc Remke, Xiaochong Wu, Readman Y. B. Chiu, Andy Chu, Eric Chuah, Richard D. Corbett, Gemma R. Hoad, Shaun D. Jackman, Yisu Li, Allan Lo, Karen L. Mungall, Ka Ming Nip, Jenny Q. Qian, Anthony G. J. Raymond, Nina Thiessen, Richard J. Varhol, Inanc Birol, Richard A. Moore, Andrew J. Mungall, Robert Holt, Daisuke Kawauchi, Martine F. Roussel, Marcel Kool, David T. W. Jones, Hendrick Witt, Africa Fernandez-L, Anna M. Kenney, Robert J. Wechsler-Reya, Peter Dirks, Tzvi Aviv, Wieslawa A. Grajkowska, Marta Perek-Polnik, Christine C. Haberler, Olivier Delattre, Stephanie S. Reynaud, Francois F. Doz, Sarah S. Pernet-Fattet, Byung-Kyu Cho, Seung-Ki Kim, Kyu-Chang Wang, Wolfram Scheurlen, Charles G. Eberhart, Michelle Fevre-Montange, Anne Jouvet, Ian F. Pollack, Xing Fan, Karin M. Muraszko, G. Yancey Gillespie, Concezio Di Rocco, Luca Massimi, Erna M. C. Michiels, Nanne K. Kloosterhof, Pim J. French, Johan M. Kros, James M. Olson, Richard G. Ellenbogen, Karel Zitterbart, Leos Kren, Reid C. Thompson, Michael K. Cooper, Boleslaw Lach, Roger E. McLendon, Darell D. Bigner, Adam Fontebasso, Steffen Albrecht, Nada Jabado, Janet C. Lindsey, Simon Bailey, Nalin Gupta, William A. Weiss, Laszlo Bognar, Almos Klekner, Timothy E. Van Meter, Toshihiro Kumabe, Teiji Tominaga, Samer K. Elbabaa, Jeffrey R. Leonard, Joshua B. Rubin, Linda M. Liau, Erwin G. Van Meir, Maryam Fouladi, Hideo Nakamura, Giuseppe Cinalli, Miklos Garami, Peter Hauser, Ali G. Saad, Achille Iolascon, Shin Jung, Carlos G. Carlotti, Rajeev Vibhakar, Young Shin Ra, Shenandoah Robinson, Massimo Zollo, Claudia C. Faria, Jennifer A. Chan, Michael L. Levy, Poul H. B. Sorensen, Matthew Meyerson, Scott L. Pomeroy, Yoon-Jae Cho, Gary D. Bader, Uri Tabori, Cynthia E. Hawkins, Eric Bouffet, Stephen W. Scherer, James T. Rutka, David Malkin, Steven C. Clifford, Steven J. M. Jones, Jan O. Korbel, Stefan M. Pfister, Marco A. Marra, Michael D. Taylor

NATURE　488　(7409)　49-56　2012/08

DOI： 10.1038/nature11327 　

ISSN： 0028-0836
Coexistence of Sporadic Cerebellar Hemangioblastoma and Pituitary Null Cell Adenoma: Simultaneous Expression of von Hippel-Lindau Gene Product -Case Report- Peer-reviewed

Yoshiteru Shimoda, Yoshikazu Ogawa, Hidenori Endo, Mika Watanabe, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　52　(8)　591-594　2012/08

DOI： 10.2176/nmc.52.591 　

ISSN： 0470-8105
Annual rupture risk of growing unruptured cerebral aneurysms detected by magnetic resonance angiography Clinical article Peer-reviewed

Takashi Inoue, Hiroaki Shimizu, Miki Fujimura, Atsushi Saito, Teiji Tominaga

JOURNAL OF NEUROSURGERY　117　(1)　20-25　2012/07

DOI： 10.3171/2012.4.JNS112225 　

ISSN： 0022-3085
An analysis of flow dynamics in cerebral cavernous malformation and orbital cavernous angioma using indocyanine green videoangiography Peer-reviewed

Kensuke Murakami, Toshiki Endo, Teiji Tominaga

ACTA NEUROCHIRURGICA　154　(7)　1169-1175　2012/07

DOI： 10.1007/s00701-012-1354-9 　

ISSN： 0001-6268
Complete remission of seizures after corpus callosotomy Peer-reviewed

Masaki Iwasaki, Mitsugu Uematsu, Yuko Sato, Tojo Nakayama, Kazuhiro Haginoya, Shin-ichiro Osawa, Hisashi Itabashi, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

JOURNAL OF NEUROSURGERY-PEDIATRICS　10　(1)　7-13　2012/07

DOI： 10.3171/2012.3.PEDS11544 　

ISSN： 1933-0707
Safety and feasibility of convection-enhanced delivery of nimustine hydrochloride co-infused with free gadolinium for real-time monitoring in the primate brain Peer-reviewed

Shin-ichiro Sugiyama, Ryuta Saito, Taigen Nakamura, Yoji Yamashita, Michiko Yokosawa, Yukihiko Sonoda, Toshihiro Kumabe, Mika Watanabe, Teiji Tominaga

NEUROLOGICAL RESEARCH　34　(6)　581-587　2012/07

DOI： 10.1179/1743132812Y.0000000050 　

ISSN： 0161-6412
Occipital Artery-Anterior Inferior Cerebellar Artery Bypass With Microsurgical Trapping for Exclusively Intra-meatal Anterior Inferior Cerebellar Artery Aneurysm Manifesting as Subarachnoid Hemorrhage -Case Report- Peer-reviewed

Miki Fujimura, Takashi Inoue, Hiroaki Shimizu, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　52　(6)　435-438　2012/06

DOI： 10.2176/nmc.52.435 　

ISSN： 0470-8105
Lessons Learned From Moyamoya Disease: Outcome of Direct/Indirect Revascularization Surgery for 150 Affected Hemispheres Peer-reviewed

Miki Fujimura, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　52　(5)　327-332　2012/05

DOI： 10.2176/nmc.52.327 　

ISSN： 0470-8105
Temporal Profile of De Novo Development of Moyamoya Vasculopathy in an Adult -Case Report Peer-reviewed

Yoshiteru Shimoda, Miki Fujimura, Takashi Inoue, Hiroaki Shimizu, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　52　(5)　339-342　2012/05

DOI： 10.2176/nmc.52.339 　

ISSN： 0470-8105
Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans. International-journal Peer-reviewed

Ayumi Narisawa, Shoko Komatsuzaki, Atsuo Kikuchi, Tetsuya Niihori, Yoko Aoki, Kazuko Fujiwara, Mitsuyo Tanemura, Akira Hata, Yoichi Suzuki, Caroline L Relton, James Grinham, Kit-Yi Leung, Darren Partridge, Alexis Robinson, Victoria Stone, Peter Gustavsson, Philip Stanier, Andrew J Copp, Nicholas D E Greene, Teiji Tominaga, Yoichi Matsubara, Shigeo Kure

Human molecular genetics　21　(7)　1496-503　2012/04/01

DOI： 10.1093/hmg/ddr585 　

ISSN： 0964-6906

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Neural tube defects (NTDs), including spina bifida and anencephaly, are common birth defects of the central nervous system. The complex multigenic causation of human NTDs, together with the large number of possible candidate genes, has hampered efforts to delineate their molecular basis. Function of folate one-carbon metabolism (FOCM) has been implicated as a key determinant of susceptibility to NTDs. The glycine cleavage system (GCS) is a multi-enzyme component of mitochondrial folate metabolism, and GCS-encoding genes therefore represent candidates for involvement in NTDs. To investigate this possibility, we sequenced the coding regions of the GCS genes: AMT, GCSH and GLDC in NTD patients and controls. Two unique non-synonymous changes were identified in the AMT gene that were absent from controls. We also identified a splice acceptor site mutation and five different non-synonymous variants in GLDC, which were found to significantly impair enzymatic activity and represent putative causative mutations. In order to functionally test the requirement for GCS activity in neural tube closure, we generated mice that lack GCS activity, through mutation of AMT. Homozygous Amt(-/-) mice developed NTDs at high frequency. Although these NTDs were not preventable by supplemental folic acid, there was a partial rescue by methionine. Overall, our findings suggest that loss-of-function mutations in GCS genes predispose to NTDs in mice and humans. These data highlight the importance of adequate function of mitochondrial folate metabolism in neural tube closure.
Extended transsphenoidal approach for tuberculum sellae meningioma-What are the optimum and critical indications? Peer-reviewed

Yoshikazu Ogawa, Teiji Tominaga

ACTA NEUROCHIRURGICA　154　(4)　621-626　2012/04

DOI： 10.1007/s00701-011-1266-0 　

ISSN： 0001-6268
[IDH gene mutation in brain tumors]. Peer-reviewed

Yukihiko Sonoda, Teiji Tominaga

No shinkei geka. Neurological surgery　40　(4)　297-306　2012/04

ISSN： 0301-2603
Consistent focal cerebral ischemia without posterior cerebral artery occlusion and its real-time monitoring in an intraluminal suture model in mice Laboratory investigation Peer-reviewed

Yosuke Akamatsu, Hiroaki Shimizu, Atsushi Saito, Miki Fujimura, Teiji Tominaga

JOURNAL OF NEUROSURGERY　116　(3)　657-664　2012/03

DOI： 10.3171/2011.11.JNS111167 　

ISSN： 0022-3085
Localization of Abnormal Discharges Causing Insular Epilepsy by Magnetoencephalography Peer-reviewed

Hyeon-Mi Park, Nobukazu Nakasato, Teiji Tominaga

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　226　(3)　207-211　2012/03

DOI： 10.1620/tjem.226.207 　

ISSN： 0040-8727

eISSN： 1349-3329
Ruptured Aneurysm of a Posterior Inferior Cerebellar Artery Communicating Artery - Case Report and Histological Findings Peer-reviewed

Shin-ichiro Sugiyama, Miki Fujimura, Takashi Inoue, Hiroaki Shimizu, Mika Watanabe, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　52　(2)　81-83　2012/02

DOI： 10.2176/nmc.52.81 　

ISSN： 0470-8105
A case of intravascular epithelioid hemangioendothelioma occurring 14 years after coil embolization for an extracranial internal carotid artery aneurysm Peer-reviewed

Shin-Ichiro Osawa, Atsushi Saito, Hiroaki Shimizu, Takenori Ogawa, Mika Watanabe, Teiji Tominaga

JOURNAL OF VASCULAR SURGERY　55　(1)　230-233　2012/01

DOI： 10.1016/j.jvs.2011.06.108 　

ISSN： 0741-5214
[Recent advances in epilepsy management]. Peer-reviewed

Kazutaka Jin, Nobukazu Nakasato, Masaki Iwasaki, Teiji Tominaga

No shinkei geka. Neurological surgery　40　(1)　5-14　2012/01

ISSN： 0301-2603
Antiplatelet therapy for prevention of thromboembolic complications associated with coil embolization of unruptured cerebral aneurysms Peer-reviewed

Yasushi Matsumoto, Ryushi Kondo, Yasuhiko Matsumori, Hiroaki Shimizu, Akira Takahashi, Teiji Tominaga

Drugs in R and D　12　(1)　1-7　2012

DOI： 10.2165/11599070-000000000-00000 　

ISSN： 1174-5886 1179-6901

eISSN： 1179-6901
Efficacy of Prophylactic Blood Pressure Lowering according to a Standardized Postoperative Management Protocol to Prevent Symptomatic Cerebral Hyperperfusion after Direct Revascularization Surgery for Moyamoya Disease Peer-reviewed

Miki Fujimura, Takashi Inoue, Hiroaki Shimizu, Atsushi Saito, Shunji Mugikura, Teiji Tominaga

CEREBROVASCULAR DISEASES　33　(5)　436-445　2012

DOI： 10.1159/000336765 　

ISSN： 1015-9770
Local Hemodynamics at the Rupture Point of Cerebral Aneurysms Determined by Computational Fluid Dynamics Analysis Peer-reviewed

Shunsuke Omodaka, Shin-ichirou Sugiyama, Takashi Inoue, Kenichi Funamoto, Miki Fujimura, Hiroaki Shimizu, Toshiyuki Hayase, Akira Takahashi, Teiji Tominaga

CEREBROVASCULAR DISEASES　34　(2)　121-129　2012

DOI： 10.1159/000339678 　

ISSN： 1015-9770
Convection-enhanced delivery: From mechanisms to clinical drug delivery for diseases of the central nervous system Peer-reviewed

Ryuta Saito, Teiji Tominaga

Neurologia Medico-Chirurgica　52　(8)　531-538　2012

DOI： 10.2176/nmc.52.531 　

ISSN： 0470-8105 1349-8029
[Physicians' emotional barriers toward epilepsy surgery]. Peer-reviewed

Nobukazu Nakasato, Kazutaka Jin, Masaki Iwasaki, Naoshi Itabashi, Teiji Tominaga

Rinsho shinkeigaku = Clinical neurology　52　(11)　1080-2　2012

DOI： 10.5692/clinicalneurol.52.1080 　

ISSN： 0009-918X

eISSN： 1882-0654

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Guidelines for epilepsy recommend timely referral of potential surgical candidate to an epilepsy center for evaluation. However, many patients are never referred for evaluation, or referred even a few decades after medically intractable condition. Physician's negative attitudes toward surgery may increase risk of morbidity and mortality in epilepsy patients. The aim of this review is to identify barriers toward epilepsy surgery among physicians. Importance of long-term epilepsy monitoring is emphasized.
Epidemiology of chronic subdural hematoma Peer-reviewed

Hiroshi Karibe, Motonobu Kameyama, Makoto Kawase, Takayuki Hirano, Tomohiro Kawaguchi, Teiji Tominaga

Neurological Surgery　39　(12)　1149-1153　2011/12/10

ISSN： 0301-2603
Prognostic factors of operated Rathke's cleft cysts with special reference to re-accumulation and recommended surgical strategy Peer-reviewed

Yoshikazu Ogawa, Mika Watanabe, Teiji Tominaga

ACTA NEUROCHIRURGICA　153　(12)　2427-2433　2011/12

DOI： 10.1007/s00701-011-1072-8 　

ISSN： 0001-6268
Subarachnoid Hemorrhage Due to Ruptured Posterior Cerebral Artery Aneurysm Simultaneously Associated With Multiple Remote Intracerebral Hemorrhages-Case Report Peer-reviewed

Shinya Sonobe, Miki Fujimura, Hidenori Endo, Takashi Inoue, Hiroaki Shimizu, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　51　(12)　836-838　2011/12

DOI： 10.2176/nmc.51.836 　

ISSN： 0470-8105
Lateralization of interictal spikes after corpus callosotomy Peer-reviewed

Masaki Iwasaki, Nobukazu Nakasato, Yosuke Kakisaka, Akitake Kanno, Mitsugu Uematsu, Kazuhiro Haginoya, Teiji Tominaga

CLINICAL NEUROPHYSIOLOGY　122　(11)　2121-2127　2011/11

DOI： 10.1016/j.clinph.2011.04.013 　

ISSN： 1388-2457
Predictive role of modified clinical diffusion mismatch in early neurological deterioration due to atherothrombotic ischemia in the anterior circulation Peer-reviewed

Atsushi Saito, Hiroaki Shimizu, Miki Fujimura, Takashi Inoue, Teiji Tominaga

ACTA NEUROCHIRURGICA　153　(11)　2205-2210　2011/11

DOI： 10.1007/s00701-011-1084-4 　

ISSN： 0001-6268
Local convection-enhanced delivery of chemotherapeutic agent transiently opens blood-brain barrier and improves efficacy of systemic chemotherapy in intracranial xenograft tumor model Peer-reviewed

Taigen Nakamura, Ryuta Saito, Shin-ichiro Sugiyama, Yukihiko Sonoda, Toshihiro Kumabe, Teiji Tominaga

CANCER LETTERS　310　(1)　77-83　2011/11

DOI： 10.1016/j.canlet.2011.06.018 　

ISSN： 0304-3835
Immunoliposomal drug-delivery system targeting lectin-like oxidized low-density lipoprotein receptor-1 for carotid plaque lesions in rats Laboratory investigation Peer-reviewed

Atsushi Saito, Hiroaki Shimizu, Yusuke Doi, Tatsuhiro Ishida, Miki Fujimura, Takashi Inoue, Hiroshi Kiwada, Teiji Tominaga

JOURNAL OF NEUROSURGERY　115　(4)　720-727　2011/10

DOI： 10.3171/2011.5.JNS10227 　

ISSN： 0022-3085
Stachybotrys microspora triprenyl phenol-7, a novel fibrinolytic agent, suppresses superoxide production, matrix metalloproteinase-9 expression, and thereby attenuates ischemia/reperfusion injury in rat brain Peer-reviewed

Yosuke Akamatsu, Atsushi Saito, Miki Fujimura, Hiroaki Shimizu, Moataz Mekawy, Keiji Hasumi, Teiji Tominaga

NEUROSCIENCE LETTERS　503　(2)　110-114　2011/10

DOI： 10.1016/j.neulet.2011.08.018 　

ISSN： 0304-3940
Logarithmic decrease of serum alpha-fetoprotein or human chorionic gonadotropin in response to chemotherapy can distinguish a subgroup with better prognosis among highly malignant intracranial non-germinomatous germ cell tumors Peer-reviewed

Tomohiro Kawaguchi, Toshihiro Kumabe, Masayuki Kanamori, Ryuta Saito, Yoji Yamashita, Yukihiko Sonoda, Mika Watanabe, Teiji Tominaga

JOURNAL OF NEURO-ONCOLOGY　104　(3)　779-787　2011/09

DOI： 10.1007/s11060-011-0544-2 　

ISSN： 0167-594X
Cerebral Blood Flow After Surgery for Unruptured Cerebral Aneurysms: Effects of Surgical Manipulation and Irrigation Fluid Peer-reviewed

Hiroaki Shimizu, Takashi Inoue, Miki Fujimura, Atsushi Saito, Teiji Tominaga

NEUROSURGERY　69　(3)　677-688　2011/09

DOI： 10.1227/NEU.0b013e3182195509 　

ISSN： 0148-396X
Combination chemotherapy with ifosfamide, cisplatin, and etoposide for medulloblastoma: single-institute experience and differences in efficacy for subgroups of medulloblastoma Peer-reviewed

Ryuta Saito, Toshihiro Kumabe, Yukihiko Sonoda, Masayuki Kanamori, Yoji Yamashita, Mika Watanabe, Teiji Tominaga

CHILDS NERVOUS SYSTEM　27　(9)　1399-1406　2011/09

DOI： 10.1007/s00381-011-1485-y 　

ISSN： 0256-7040
Ruptured aneurysm at the anterior wall of the internal carotid artery in a patient with systemic lupus erythematosus and secondary antiphospholipid syndrome Peer-reviewed

Masashi Chonan, Miki Fujimura, Takashi Inoue, Teiji Tominaga

Neurological Surgery　39　(7)　675-680　2011/07/10

ISSN： 0301-2603
Asymptomatic intracerebral hemorrhage under strict blood pressure control due to postoperative cerebral hyperperfusion in a patient with moyamoya disease Peer-reviewed

Akira Ito, Miki Fujimura, Takashi Inoue, Teiji Tominaga

Neurological Surgery　39　(7)　681-686　2011/07/10

ISSN： 0301-2603
New insights into glioma classification based on isocitrate dehydrogenase 1 and 2 gene status Peer-reviewed

Ichiyo Shibahara, Yukihiko Sonoda, Masayuki Kanamori, Ryuta Saito, Toshihiro Kumabe, Teiji Tominaga

BRAIN TUMOR PATHOLOGY　28　(3)　203-208　2011/07

DOI： 10.1007/s10014-011-0050-4 　

ISSN： 1433-7398
Angiocentric Glioma and Surrounding Cortical Dysplasia Manifesting as Intractable Frontal Lobe Epilepsy-Case Report Peer-reviewed

Shihomi Takada, Masaki Iwasaki, Hiroyoshi Suzuki, Nobukazu Nakasato, Toshihiro Kumabe, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　51　(7)　522-526　2011/07

DOI： 10.2176/nmc.51.522 　

ISSN： 0470-8105

eISSN： 1349-8029
Mechanisms of Primary Blast-Induced Traumatic Brain Injury: Insights from Shock-Wave Research Peer-reviewed

Atsuhiro Nakagawa, Geoffrey T. Manley, Alisa D. Gean, Kiyonobu Ohtani, Rocco Armonda, Akira Tsukamoto, Hiroaki Yamamoto, Kazuyoshi Takayama, Teiji Tominaga

JOURNAL OF NEUROTRAUMA　28　(6)　1101-1119　2011/06

DOI： 10.1089/neu.2010.1442 　

ISSN： 0897-7151
Development of intratumoral cyst or extratumoral arachnoid cyst in intracranial schwannomas following gamma knife radiosurgery Peer-reviewed

Kensuke Murakami, Hidefumi Jokura, Jun Kawagishi, Mika Watanabe, Teiji Tominaga

ACTA NEUROCHIRURGICA　153　(6)　1201-1209　2011/06

DOI： 10.1007/s00701-011-0972-y 　

ISSN： 0001-6268
Intraorbital Arteriovenous Malformation Treated by Transarterial Embolization: Technical Case Report Peer-reviewed

Kenichi Sato, Yasushi Matsumoto, Ryushi Kondo, Teiji Tominaga

NEUROSURGERY　68　(2 Suppl Operative)　383-387　2011/06

DOI： 10.1227/NEU.0b013e31821522ec 　

ISSN： 0148-396X
Extradural dermoid cyst of the parasellar region: a case report. Peer-reviewed

Endo H, Murakami K, Watanabe M, Tominaga T

Skull base reports　1　(1)　3-6　2011/05

DOI： 10.1055/s-0030-1263284 　

ISSN： 2157-6971
Regression of recurrent glioblastoma infiltrating the brainstem after convection-enhanced delivery of nimustine hydrochloride Case report Peer-reviewed

Ryuta Saito, Yukihiko Sonoda, Toshihiro Kumabe, Ken-ichi Nagamatsu, Mika Watanabe, Teiji Tominaga

JOURNAL OF NEUROSURGERY-PEDIATRICS　7　(5)　522-526　2011/05

DOI： 10.3171/2011.2.PEDS10407 　

ISSN： 1933-0707
Characteristics of an actuator-driven pulsed water jet generator to dissecting soft tissue Peer-reviewed

Takeshi Seto, Hiroaki Yamamoto, Kazuyoshi Takayama, Atsuhiro Nakagawa, Teiji Tominaga

REVIEW OF SCIENTIFIC INSTRUMENTS　82　(5)　055105　2011/05

DOI： 10.1063/1.3587069 　

ISSN： 0034-6748
Infratentorial brain metastases of pediatric non-epithelial malignant tumors: three case reports Peer-reviewed

Shin-ichiro Osawa, Toshihiro Kumabe, Ryuta Saito, Yukihiko Sonoda, Hidetaka Niizuma, Mika Watanabe, Teiji Tominaga

BRAIN TUMOR PATHOLOGY　28　(2)　167-174　2011/04

DOI： 10.1007/s10014-010-0014-0 　

ISSN： 1433-7398

eISSN： 1861-387X
Significance of focal cerebral hyperperfusion as a cause of transient neurologic deterioration after extracranial-intracranial bypass for moyamoya disease: comparative study with non-moyamoya patients using N-isopropyl-p-[(123)I]iodoamphetamine single-pho Peer-reviewed

Fujimura M, Shimizu H, Inoue T, Mugikura S, Saito A, Tominaga T

Neurosurgery　68　(4)　957-64; discussion 964　2011/04

DOI： 10.1227/NEU.0b013e318208f1da 　

ISSN： 0148-396X
Pulsed laser-induced liquid jet for skull base tumor removal with vascular preservation through the transsphenoidal approach: a clinical investigation Peer-reviewed

Yoshikazu Ogawa, Atsuhiro Nakagawa, Kazuyoshi Takayama, Teiji Tominaga

ACTA NEUROCHIRURGICA　153　(4)　823-830　2011/04

DOI： 10.1007/s00701-010-0925-x 　

ISSN： 0001-6268
Prognostic factors for patients with gliomatosis cerebri: retrospective analysis of 17 consecutive cases Peer-reviewed

Tomoo Inoue, Toshihiro Kumabe, Masayuki Kanamori, Yukihiko Sonoda, Mika Watanabe, Teiji Tominaga

NEUROSURGICAL REVIEW　34　(2)　197-207　2011/04

DOI： 10.1007/s10143-010-0306-1 　

ISSN： 0344-5607
Compromise of Brain Tissue Caused by Cortical Venous Reflux of Intracranial Dural Arteriovenous Fistulas Assessment With Diffusion-Weighted Magnetic Resonance Imaging Peer-reviewed

Kenichi Sato, Hiroaki Shimizu, Miki Fujimura, Takashi Inoue, Yasushi Matsumoto, Teiji Tominaga

STROKE　42　(4)　998-1003　2011/04

DOI： 10.1161/STROKEAHA.110.597203 　

ISSN： 0039-2499
Hemosiderin Detected by T-2*-Weighted Magnetic Resonance Imaging in Patients With Unruptured Cerebral Aneurysms: Indication of Previous Bleeding? Peer-reviewed

Shihomi Takada, Takashi Inoue, Kuniyasu Niizuma, Hiroaki Shimizu, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　51　(4)　275-281　2011/04

DOI： 10.2176/nmc.51.275 　

ISSN： 0470-8105
Cerebral Arteritis With Extremely Late Onset Secondary to Bacterial Meningitis-Case Report Peer-reviewed

Tomohiro Kawaguchi, Yoshikazu Ogawa, Takashi Inoue, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　51　(4)　302-305　2011/04

DOI： 10.2176/nmc.51.302 　

ISSN： 0470-8105
Simultaneous Occurrence of Subarachnoid Hemorrhage and Epistaxis Due to Ruptured Petrous Internal Carotid Artery Aneurysm: Association With Transsphenoidal Surgery and Radiation Therapy-Case Report Peer-reviewed

Hidenori Endo, Miki Fujimura, Takashi Inoue, Yasushi Matsumoto, Yoshikazu Ogawa, Jun Kawagishi, Hidefumi Jokura, Hiroaki Shimizu, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　51　(3)　226-229　2011/03

DOI： 10.2176/nmc.51.226 　

ISSN： 0470-8105
Early detection of venous thromboembolism in patients with neuroepithelial tumor: efficacy of screening with serum d-dimer measurements and Doppler ultrasonography Peer-reviewed

Tomohiro Kawaguchi, Toshihiro Kumabe, Masayuki Kanamori, Taigen Nakamura, Ryuta Saito, Yoji Yamashita, Yukihiko Sonoda, Mika Watanabe, Teiji Tominaga

JOURNAL OF NEURO-ONCOLOGY　101　(3)　495-504　2011/02

DOI： 10.1007/s11060-010-0276-8 　

ISSN： 0167-594X

eISSN： 1573-7373
Prediction of neurological recovery using apparent diffusion coefficient in cases of incomplete spinal cord injury. Peer-reviewed

Endo T, Suzuki S, Utsunomiya A, Uenohara H, Tominaga T

Neurosurgery　68　(2)　329-336　2011/02

DOI： 10.1227/NEU.0b013e3182031ce7 　

ISSN： 0148-396X
A genome-wide association study identifies RNF213 as the first Moyamoya disease gene. International-journal Peer-reviewed

Fumiaki Kamada, Yoko Aoki, Ayumi Narisawa, Yu Abe, Shoko Komatsuzaki, Atsuo Kikuchi, Junko Kanno, Tetsuya Niihori, Masao Ono, Naoto Ishii, Yuji Owada, Miki Fujimura, Yoichi Mashimo, Yoichi Suzuki, Akira Hata, Shigeru Tsuchiya, Teiji Tominaga, Yoichi Matsubara, Shigeo Kure

Journal of human genetics　56　(1)　34-40　2011/01

DOI： 10.1038/jhg.2010.132 　

ISSN： 1434-5161

More details Close

Moyamoya disease (MMD) shows progressive cerebral angiopathy characterized by bilateral internal carotid artery stenosis and abnormal collateral vessels. Although ∼ 15% of MMD cases are familial, the MMD gene(s) remain unknown. A genome-wide association study of 785,720 single-nucleotide polymorphisms (SNPs) was performed, comparing 72 Japanese MMD patients with 45 Japanese controls and resulting in a strong association of chromosome 17q25-ter with MMD risk. This result was further confirmed by a locus-specific association study using 335 SNPs in the 17q25-ter region. A single haplotype consisting of seven SNPs at the RNF213 locus was tightly associated with MMD (P = 5.3 × 10(-10)). RNF213 encodes a really interesting new gene finger protein with an AAA ATPase domain and is abundantly expressed in spleen and leukocytes. An RNA in situ hybridization analysis of mouse tissues indicated that mature lymphocytes express higher levels of Rnf213 mRNA than their immature counterparts. Mutational analysis of RNF213 revealed a founder mutation, p.R4859K, in 95% of MMD families, 73% of non-familial MMD cases and 1.4% of controls; this mutation greatly increases the risk of MMD (P = 1.2 × 10(-43), odds ratio = 190.8, 95% confidence interval = 71.7-507.9). Three additional missense mutations were identified in the p.R4859K-negative patients. These results indicate that RNF213 is the first identified susceptibility gene for MMD.
Neuromonitoring and neurocritical care for severe TBI: Current update Peer-reviewed

Atsuhiro Nakagawa, Teiji Tominaga, Geoffrey Manley

Neurological Surgery　38　(12)　1081-1095　2010/12/10

ISSN： 0301-2603
In Reply. International-journal Peer-reviewed

Hayashi T, Shirane R, Tominaga T

Neurosurgery　67　(6)　E1866　2010/12

DOI： 10.1227/NEU.0b013e3181faa69c 　

ISSN： 0148-396X

eISSN： 1524-4040
Developmental venous anomaly presenting as a brain parenchymal abnormality mimicking a brain tumor - A report of 3 cases and review of literature Peer-reviewed

Takahiro Morita, Hiroaki Shimizu, Toshihiro Kumabe, Atsushi Saito, Teiji Tominaga

Brain and Nerve　62　(12)　1331-1336　2010/12

ISSN： 1881-6096
Paradoxical Association of Moyamoya Syndrome With Large Middle Cerebral Artery Aneurysm and Subarachnoid Hemorrhage -Case Report Peer-reviewed

Hidenori Endo, Miki Fujimura, Takashi Inoue, Hiroaki Shimizu, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　50　(12)　1088-1091　2010/12

DOI： 10.2176/nmc.50.1088 　

ISSN： 0470-8105
[The safety of combination chemotherapy with ifosfamide, cisplatin, and etoposide (ICE): single-institution retrospective review of 108 cases]. Peer-reviewed

Masayuki Kanamori, Toshihiro Kumabe, Ryuta Saito, Yoji Yamashita, Yukihiko Sonoda, Teiji Tominaga

No shinkei geka. Neurological surgery　38　(11)　997-1005　2010/11

ISSN： 0301-2603

More details Close

PURPOSE: The adverse effects of combination chemotherapy of ifosfamide, cisplatin, and etoposide (ICE) were evaluated in the treatment of various intracranial brain tumors. METHODS: 108 cases were retrospectively reviewed. The histological diagnosis was newly diagnosed or recurrent germ cell tumor in 45 cases, medulloblastoma in 19, primitive neuroectodermal tumor (PNET) in 7, anaplastic ependymoma in 6, recurrent glioblastoma in 13, and others in 18 cases. Patients received 1-8 cycles of ICE chemotherapy with or without radiation therapy. The adverse effects were analyzed based on the the clinical or laboratory examinations. RESULTS: Common Terminology Criteria for Adverse Events ver. 3.0 (CTCAE v3.0) grade 4 neutropenia, anemia, and thrombocytopenia occurred in 81.4%, 14.8%, and 35.2% of patients, respectively. Non-hematological adverse effects, including infection, elevated aspartate aminotransferase (AST)/alanine aminotransferase (ALT), high or low levels of serum sodium, and seizure, occurred in 26.8%, 29.6%, 28.7%, and 11.1% of patients, respectively. One patient died of opportunistic infection with neutropenia. The proportion of ICE cycles associated with CTCAE v3.0 grade 4 neutropenia, transfusion of platelets, and elevated AST/ALT significantly decreased after enforcement of dose reduction criteria. CONCLUSION: The high rate of adverse effects requires close follow up and dose reduction.
Efficacy of Revascularization Surgery for Moyamoya Syndrome Associated With Graves' Disease Peer-reviewed

Hidenori Endo, Miki Fujimura, Kuniyasu Niizuma, Hiroaki Shimizu, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　50　(11)　977-983　2010/11

DOI： 10.2176/nmc.50.977 　

ISSN： 0470-8105
CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples Peer-reviewed

Yoji Yamashita, Isao Kasugai, Masami Sato, Nobuhiro Tanuma, Ikuro Sato, Miyuki Nomura, Katsumi Yamashita, Yukihiko Sonoda, Toshihiro Kumabe, Teiji Tominaga, Ryuichi Katakura, Hiroshi Shima

JOURNAL OF NEURO-ONCOLOGY　100　(1)　43-49　2010/10

DOI： 10.1007/s11060-010-0147-3 　

ISSN： 0167-594X

eISSN： 1573-7373
Efficacy of intraoperative irrigation with saline for preventing shunt infection Clinical article Peer-reviewed

Toshiaki Hayashi, Reizo Shirane, Michiko Yokosawa, Tomomi Kimiwada, Teiji Tominaga

JOURNAL OF NEUROSURGERY-PEDIATRICS　6　(3)　273-276　2010/09

DOI： 10.3171/2010.5.PEDS1018 　

ISSN： 1933-0707
Imaging of hypoxic lesions in patients with gliomas by using positron emission tomography with 1-(2-[(18)F]fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole, a new (18)F-labeled 2-nitroimidazole analog Clinical article Peer-reviewed

Ichiyo Shibahara, Toshihiro Kumabe, Masayuki Kanamori, Ryuta Saito, Yukihiko Sonoda, Mika Watanabe, Ren Iwata, Shuichi Higano, Kentaro Takanami, Yoshihiro Takai, Teiji Tominaga

JOURNAL OF NEUROSURGERY　113　(2)　358-368　2010/08

DOI： 10.3171/2009.10.JNS09510 　

ISSN： 0022-3085
O (6)-Methylguanine DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression is correlated with progression-free survival in patients with glioblastoma Peer-reviewed

Yukihiko Sonoda, Michiko Yokosawa, Ryuta Saito, Masayuki Kanamori, Yoji Yamashita, Toshihiro Kumabe, Mika Watanabe, Teiji Tominaga

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY　15　(4)　352-358　2010/08

DOI： 10.1007/s10147-010-0065-6 　

ISSN： 1341-9625
Convection-Enhanced Delivery of a Synthetic Retinoid Am80, Loaded into Polymeric Micelles, Prolongs the Survival of Rats Bearing Intracranial Glioblastoma Xenografts Peer-reviewed

Michiko Yokosawa, Yukihiko Sonoda, Shin-ichiro Sugiyama, Ryuta Saito, Yoji Yamashita, Masamichi Nishihara, Taku Satoh, Toshihiro Kumabe, Masayuki Yokoyama, Teiji Tominaga

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　221　(4)　257-264　2010/08

DOI： 10.1620/tjem.221.257 　

ISSN： 0040-8727

eISSN： 1349-3329
Usefulness of C-Arm Cone-Beam Computed Tomography in Endovascular Treatment of Traumatic Carotid Cavernous Fistulas: A Technical Case Report Peer-reviewed

Kenichi Sato, Yasushi Matsumoto, Ryushi Kondo, Teiji Tominaga

NEUROSURGERY　67　(2)　467-469　2010/08

DOI： 10.1227/01.NEU.0000372087.71176.FB 　

ISSN： 0148-396X
Lectin-like oxidized low-density lipoprotein receptor 1 and matrix metalloproteinase expression in ruptured and unruptured multiple dissections of distal middle cerebral artery: case report Peer-reviewed

Atsushi Saito, Miki Fujimura, Takashi Inoue, Hiroaki Shimizu, Teiji Tominaga

ACTA NEUROCHIRURGICA　152　(7)　1235-1240　2010/07

DOI： 10.1007/s00701-009-0560-6 　

ISSN： 0001-6268
Postoperative neurological deterioration in pediatric moyamoya disease: watershed shift and hyperperfusion Clinical article Peer-reviewed

Toshiaki Hayashi, Reizo Shirane, Miki Fujimura, Teiji Tominaga

JOURNAL OF NEUROSURGERY-PEDIATRICS　6　(1)　73-81　2010/07

DOI： 10.3171/2010.4.PEDS09478 　

ISSN： 1933-0707
A partially ossified solid and cystic Rathke cleft cyst Peer-reviewed

Yoshikazu Ogawa, Teiji Tominaga

JOURNAL OF NEUROSURGERY　112　(6)　1324-1326　2010/06

DOI： 10.3171/2009.10.JNS09826 　

ISSN： 0022-3085
Acute-stage diffusion-weighted magnetic resonance imaging for predicting outcome of poor-grade aneurysmal subarachnoid hemorrhage Peer-reviewed

Kenichi Sato, Hiroaki Shimizu, Miki Fujimura, Takashi Inoue, Yasushi Matsumoto, Teiji Tominaga

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　30　(6)　1110-1120　2010/06

DOI： 10.1038/jcbfm.2009.264 　

ISSN： 0271-678X
Somatostatin-Producing Atypical Null Cell Adenoma Manifesting as Severe Hypopituitarism and Rapid Deterioration-Case Report Peer-reviewed

Yoshikazu Ogawa, Mika Watanabe, Teiji Tominaga

ENDOCRINE PATHOLOGY　21　(2)　130-134　2010/06

DOI： 10.1007/s12022-010-9110-2 　

ISSN： 1046-3976
Surgical treatment of spinal intradural arachnoid cysts using endoscopy Clinical article Peer-reviewed

Toshiki Endo, Toshiyuki Takahashi, Hidefumi Jokura, Teiji Tominaga

JOURNAL OF NEUROSURGERY-SPINE　12　(6)　641-646　2010/06

DOI： 10.3171/2009.12.SPINE09577 　

ISSN： 1547-5654
Malignant Peripheral Nerve Sheath Tumor Arising From Benign Vestibular Schwannoma Treated by Gamma Knife Radiosurgery After Two Previous Surgeries: A Case Report With Surgical and Pathological Observations Peer-reviewed

Yosuke Akamatsu, Kensuke Murakami, Mika Watanabe, Hidefumi Jokura, Teiji Tominaga

WORLD NEUROSURGERY　73　(6)　751-754　2010/06

DOI： 10.1016/j.wneu.2010.04.009 　

ISSN： 1878-8750
Relationship between lectin-like oxidized low-density lipoprotein receptor 1 expression and preoperative echogenic findings of vulnerable carotid plaque Peer-reviewed

Atsushi Saito, Miki Fujimura, Takashi Inoue, Hiroaki Shimizu, Teiji Tominaga

ACTA NEUROCHIRURGICA　152　(4)　589-595　2010/04

DOI： 10.1007/s00701-009-0573-1 　

ISSN： 0001-6268
Association of stem cell marker CD133 expression with dissemination of glioblastomas Peer-reviewed

Atsushi Sato, Kaori Sakurada, Toshihiro Kumabe, Toshio Sasajima, Takaaki Beppu, Kenichiro Asano, Hiroki Ohkuma, Akira Ogawa, Kazuo Mizoi, Teiji Tominaga, Chifumi Kitanaka, Takamasa Kayama

NEUROSURGICAL REVIEW　33　(2)　175-183　2010/04

DOI： 10.1007/s10143-010-0239-8 　

ISSN： 0344-5607
Dissemination limits the survival of patients with anaplastic ependymoma after extensive surgical resection, meticulous follow up, and intensive treatment for recurrence. Peer-reviewed

Saito R, Kumabe T, Kanamori M, Sonoda Y, Tominaga T

Neurosurgical review　33　(2)　185-91; discussion 191　2010/04

DOI： 10.1007/s10143-010-0243-z 　

ISSN： 0344-5607
2-hydroxyglutarate accumulation caused by IDH mutation is involved in the formation of malignant gliomas Peer-reviewed

Yukihiko Sonoda, Teiji Tominaga

EXPERT REVIEW OF NEUROTHERAPEUTICS　10　(4)　487-489　2010/04

DOI： 10.1586/ERN.10.19 　

ISSN： 1473-7175
Melanotic neuroectodermal tumor of the brain recurring 12 years after complete remission: case report Peer-reviewed

Shunsuke Omodaka, Ryuta Saito, Toshihiro Kumabe, Jun Kawagishi, Hidefumi Jokura, Yukihiko Sonoda, Mika Watanabe, Takamasa Kayama, Teiji Tominaga

BRAIN TUMOR PATHOLOGY　27　(1)　51-57　2010/04

DOI： 10.1007/s10014-010-0263-y 　

ISSN： 1433-7398
Insulo-opercular Gliomas: Four Different Natural Progression Patterns and Implications for Surgical Indications Peer-reviewed

Ryuta Saito, Toshihiro Kumabe, Masayuki Kanamori, Yukihiko Sonoda, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　50　(4)　286-290　2010/04

DOI： 10.2176/nmc.50.286 　

ISSN： 0470-8105
Asymptomatic Moyamoya Disease Subsequently Manifesting as Transient Ischemic Attack, Intra cerebral Hemorrhage, and Subarachnoid Hemorrhage in a Short Period-Case Report Peer-reviewed

Miki Fujimura, Shunji Mugikura, Hiroaki Shimizu, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　50　(4)　316-319　2010/04

DOI： 10.2176/nmc.50.316 　

ISSN： 0470-8105
De Novo Formation of Orbital Cavernous Malformation 9 Years After Surgical Management of Dural Arteriovenous Fistula in the Anterior Middle Fossa-Case Report Peer-reviewed

Shunsuke Omodaka, Miki Fujimura, Toshiki Endo, Takashi Inoue, Hiroaki Shimizu, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　50　(4)　324-327　2010/04

DOI： 10.2176/nmc.50.324 　

ISSN： 0470-8105
Non-saccular aneurysms of the supraclinoid internal carotid artery trunk causing subarachnoid hemorrhage: acute surgical treatments and review of literatures. Peer-reviewed

Shimizu H, Matsumoto Y, Tominaga T

Neurosurgical review　33　(2)　205-216　2010/04

DOI： 10.1007/s10143-009-0234-0 　

ISSN： 0344-5607
Long-term Outcome of Cervical and Thoracolumbar Dural Arteriovenous Fistulas With Emphasis on Sensory Disturbance and Neuropathic Pain Peer-reviewed

Mizuya Shinoyama, Toshiki Endo, Toshiyuki Takahash, Hiroaki Shimizu, Akira Takahashi, Michiyasu Suzuki, Teiji Tominaga

WORLD NEUROSURGERY　73　(4)　401-408　2010/04

DOI： 10.1016/j.wneu.2010.01.003 　

ISSN： 1878-8750
Effect of olmesartan and pravastatin on experimental cerebral aneurysms in rats Peer-reviewed

Naoto Kimura, Hiroaki Shimizu, Hany Eldawoody, Toshio Nakayama, Atsushi Saito, Teiji Tominaga, Akira Takahashi

BRAIN RESEARCH　1322　144-152　2010/03

DOI： 10.1016/j.brainres.2010.01.044 　

ISSN： 0006-8993
Fasudil, a Rho-kinase inhibitor, attenuates induction and progression of cerebral aneurysms: Experimental study in rats using vascular corrosion casts Peer-reviewed

Hany Eldawoody, Hiroaki Shimizu, Naoto Kimura, Atsushi Saito, Toshio Nakayama, Akira Takahashi, Teiji Tominaga

NEUROSCIENCE LETTERS　470　(1)　76-80　2010/02

DOI： 10.1016/j.neulet.2009.12.061 　

ISSN： 0304-3940
Extracranial Metastasis of Anaplastic Oligodendroglioma With 1p19q Loss of Heterozygosity -Case Report- Peer-reviewed

Nobuo Noshita, Shoji Mashiyama, Osamu Fukawa, Shigeyuki Asano, Mika Watanabe, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　50　(2)　161-164　2010/02

DOI： 10.2176/nmc.50.161 　

ISSN： 0470-8105
Parent artery occlusion with bypass surgery for the treatment of internal carotid artery aneurysms: Clinical and hemodynamic results Peer-reviewed

Hiroaki Shimizu, Yasushi Matsumoto, Teiji Tominaga

CLINICAL NEUROLOGY AND NEUROSURGERY　112　(1)　32-39　2010/01

DOI： 10.1016/j.clineuro.2009.10.002 　

ISSN： 0303-8467
Simultaneous occurrence of subarachnoid hemorrhage and cerebral infarction caused by anterior cerebral artery dissection treated by endovascular trapping. Peer-reviewed

Inoue T, Fujimura M, Matsumoto Y, Kondo R, Inoue T, Shimizu H, Tominaga T

Neurologia medico-chirurgica　50　(7)　574-577　2010

DOI： 10.2176/nmc.50.574 　

ISSN： 0470-8105
Cushing's disease associated with unruptured large internal carotid artery aneurysm. Case report. Peer-reviewed

Nishijima Y, Ogawa Y, Sato K, Matsumoto Y, Tominaga T

Neurologia medico-chirurgica　50　(8)　665-668　2010

DOI： 10.2176/nmc.50.665 　

ISSN： 0470-8105
Subependymoma in the lateral ventricle manifesting as intraventricular hemorrhage. Peer-reviewed

Akamatsu Y, Utsunomiya A, Suzuki S, Endo T, Suzuki I, Nishimura S, Ezura M, Suzuki H, Uenohara H, Tominaga T

Neurologia medico-chirurgica　50　(11)　1020-1023　2010

DOI： 10.2176/nmc.50.1020 　

ISSN： 0470-8105
Minimum apparent diffusion coefficient for the differential diagnosis of ganglioglioma Peer-reviewed

Toshio Kikuchi, Toshihiro Kumabe, Shuichi Higano, Mika Watanabe, Teiji Tominaga

NEUROLOGICAL RESEARCH　31　(10)　1102-1107　2009/12

DOI： 10.1179/174313209X382539 　

ISSN： 0161-6412
Clinical implications of intraoperative infrared brain surface monitoring during superficial temporal artery-middle cerebral artery anastomosis in patients with moyamoya disease Clinical article Peer-reviewed

Atsuhiro Nakagawa, Miki Fujimura, Tatsuhiko Arafune, Ichiro Sakuma, Teiji Tominaga

JOURNAL OF NEUROSURGERY　111　(6)　1158-1164　2009/12

DOI： 10.3171/2009.4.JNS08585 　

ISSN： 0022-3085
Optimal treatment strategy for intracranial germ cell tumors: a single institution analysis Clinical article Peer-reviewed

Masayuki Kanamori, Toshihiro Kumabe, Ryuta Saito, Yoji Yamashita, Yukihiko Sonoda, Hisanori Ariga, Yoshihiro Takai, Teiji Tominaga

JOURNAL OF NEUROSURGERY-PEDIATRICS　4　(6)　506-514　2009/12

DOI： 10.3171/2009.7.PEDS08288 　

ISSN： 1933-0707
[Intraoperative neuronavigation system without rigid pin fixation]. Peer-reviewed

Akamatsu Y, Kumabe T, Kanamori M, Nagamatsu K, Saito R, Sonoda Y, Sato K, Tominaga T

No shinkei geka. Neurological surgery　37　(12)　1193-1199　2009/12

ISSN： 0301-2603
Differentiation of Clear Cell Ependymoma of the Cerebellum From Hemangioblastoma by Thallium-201 Single Photon Emission Computed Tomography-Case Report Peer-reviewed

Ken-ichi Nagamatsu, Toshihiro Kumabe, Mika Watanabe, Yoichi Nakazato, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　49　(12)　608-611　2009/12

DOI： 10.2176/nmc.49.608 　

ISSN： 0470-8105
Hypophysitis Presenting With Atypical Rapid Deterioration: With Special Reference to Immunoglobulin G4-Related Disease-Case Report Peer-reviewed

Shinichiro Osawa, Yoshikazu Ogawa, Mika Watanabe, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　49　(12)　622-625　2009/12

DOI： 10.2176/nmc.49.622 　

ISSN： 0470-8105

eISSN： 1349-8029
Minimum apparent diffusion coefficient is significantly correlated with cellularity in medulloblastomas Peer-reviewed

Yoji Yamashita, Toshihiro Kumabe, Shuichi Higano, Mika Watanabe, Teiji Tominaga

NEUROLOGICAL RESEARCH　31　(9)　940-946　2009/11

DOI： 10.1179/174313209X382520 　

ISSN： 0161-6412
Increased expression of serum matrix metalloproteinase-9 in patients with moyamoya disease Peer-reviewed

Miki Fujimura, Mika Watanabe, Ayumi Narisawa, Hiroaki Shimizu, Teiji Tominaga

SURGICAL NEUROLOGY　72　(5)　476-480　2009/11

DOI： 10.1016/j.surneu.2008.10.009 　

ISSN： 0090-3019
Long-term survivors of glioblastoma: clinical features and molecular analysis Peer-reviewed

Yukihiko Sonoda, Toshihiro Kumabe, Mika Watanabe, Yoichi Nakazato, Tomoo Inoue, Masayuki Kanamori, Teiji Tominaga

ACTA NEUROCHIRURGICA　151　(11)　1349-1358　2009/11

DOI： 10.1007/s00701-009-0387-1 　

ISSN： 0001-6268
Simplified experimental cerebral aneurysm model in rats: Comprehensive evaluation of induced aneurysms and arterial changes in the circle of Willis Peer-reviewed

Hany Eldawoody, Hiroaki Shimizu, Naoto Kimura, Atsushi Saito, Toshio Nakayama, Akira Takahashi, Teiji Tominaga

BRAIN RESEARCH　1300　159-168　2009/11

DOI： 10.1016/j.brainres.2009.08.099 　

ISSN： 0006-8993
Neuroendoscopic management of symptomatic septum pellucidum cavum vergae cyst using a high-definition flexible endoscopic system. Peer-reviewed

Nishijima Y, Fujimura M, Nagamatsu K, Kohama M, Tominaga T

Neurologia medico-chirurgica　49　(11)　549-552　2009/11

DOI： 10.2176/nmc.49.549 　

ISSN： 0470-8105
Analysis of IDH1 and IDH2 mutations in Japanese glioma patients Peer-reviewed

Yukihiko Sonoda, Toshihiro Kumabe, Taigen Nakamura, Ryuta Saito, Masayuki Kanamori, Yoji Yamashita, Hiroyoshi Suzuki, Teiji Tominaga

CANCER SCIENCE　100　(10)　1996-1998　2009/10

DOI： 10.1111/j.1349-7006.2009.01270.x 　

ISSN： 1347-9032
Collision tumor of anaplastic oligodendroglioma and gangliocytoma: a case report Peer-reviewed

Yoichi Takeuchi, Masayuki Kanamori, Toshihiro Kumabe, Ryuta Saito, Yukihiko Sonoda, Mika Watanabe, Teiji Tominaga

BRAIN TUMOR PATHOLOGY　26　(2)　89-93　2009/10

DOI： 10.1007/s10014-009-0255-y 　

ISSN： 1433-7398
[C2 neurinoma with intracranial extension: a case report]. Peer-reviewed

Sonobe S, Murakami K, Kohama M, Watanabe M, Kumabe T, Tominaga T

No shinkei geka. Neurological surgery　37　(9)　893-897　2009/09

ISSN： 0301-2603
Differential Diagnosis Between Radiation Necrosis and Glioma Progression Using Sequential Proton Magnetic Resonance Spectroscopy and Methionine Positron Emission Tomography Peer-reviewed

Takeshi Nakajima, Toshihiro Kumabe, Masayuki Kanamori, Ryuta Saito, Manabu Tashiro, Mika Watanabe, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　49　(9)　394-401　2009/09

DOI： 10.2176/nmc.49.394 　

ISSN： 0470-8105
Magnetic resonance imaging for preoperative identification of the lenticulostriate arteries in insular glioma surgery Technical note Peer-reviewed

Ryuta Saito, Toshihiro Kumabe, Takashi Inoue, Shihomi Takada, Yoji Yamashita, Masayuki Kanamori, Yukihiko Sonoda, Teiji Tominaga

JOURNAL OF NEUROSURGERY　111　(2)　278-281　2009/08

DOI： 10.3171/2008.11.JNS08858 　

ISSN： 0022-3085
Temporo-parietal theta activity correlates with misery perfusion in arterial occlusive disease Peer-reviewed

Satoru Ohtomo, Nobukazu Nakasato, Hiroaki Shimizu, Shintarou Seki, Akitake Kanno, Toshihiro Kumabe, Teiji Tominaga

CLINICAL NEUROPHYSIOLOGY　120　(7)　1227-1234　2009/07

DOI： 10.1016/j.clinph.2009.05.015 　

ISSN： 1388-2457

eISSN： 1872-8952
[Surgery of internal carotid--posterior communicating artery aneurysms]. Peer-reviewed

Shimizu H, Tominaga T

No shinkei geka. Neurological surgery　37　(7)　633-642　2009/07

ISSN： 0301-2603
Predictive factors for overall and progression-free survival, and dissemination in oligodendroglial tumors Peer-reviewed

Masayuki Kanamori, Toshihiro Kumabe, Yukihiko Sonoda, Yoshikazu Nishino, Mika Watanabe, Teiji Tominaga

JOURNAL OF NEURO-ONCOLOGY　93　(2)　219-228　2009/06

DOI： 10.1007/s11060-008-9762-7 　

ISSN： 0167-594X
Endfolium sclerosis in temporal lobe epilepsy diagnosed preoperatively by 3-tesla magnetic resonance imaging Case report Peer-reviewed

Masaki Iwasaki, Nobukazu Nakasato, Hiroyoshi Suzuki, Teiji Tominaga

JOURNAL OF NEUROSURGERY　110　(6)　1124-1126　2009/06

DOI： 10.3171/2008.11.JNS081109 　

ISSN： 0022-3085
Cortical Changes Following Spinal Cord Injury with Emphasis on the Nogo Signaling System Peer-reviewed

Toshiki Endo, Teiji Tominaga, Lars Olson

NEUROSCIENTIST　15　(3)　291-299　2009/06

DOI： 10.1177/1073858408329508 　

ISSN： 1073-8584
[A case report of cerebellar pleomorphic xanthoastrocytoma]. Peer-reviewed

Mano Y, Kanamori M, Sonoda Y, Kumabe T, Watanabe M, Tominaga T

No shinkei geka. Neurological surgery　37　(6)　586-590　2009/06

ISSN： 0301-2603
[Surgery of glioma]. Peer-reviewed

Kumabe T, Tominaga T

Gan to kagaku ryoho. Cancer & chemotherapy　36　(6)　928-931　2009/06

ISSN： 0385-0684
Clock genes regulate neurogenic transcription factors, including NeuroD1, and the neuronal differentiation of adult neural stem/progenitor cells Peer-reviewed

Tomomi Kimiwada, Mikako Sakurai, Hiroki Ohashi, Shunsuke Aoki, Teiji Tominaga, Keiji Wada

NEUROCHEMISTRY INTERNATIONAL　54　(5-6)　277-285　2009/05

DOI： 10.1016/j.neuint.2008.12.005 　

ISSN： 0197-0186
Surgical and Histological Observations of Trochlear Neurinoma -Case Report- Peer-reviewed

Misaki Kohama, Kensuke Murakami, Toshiki Endo, Mika Watanabe, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　49　(5)　217-220　2009/05

DOI： 10.2176/nmc.49.217 　

ISSN： 0470-8105
Standardizing the diagnosis of acute ischemic stroke - The concept of an institutional manual and its clinical impact Peer-reviewed

Hiroaki Shimizu, Eisuke Furui, Hiroshi Shamoto, Akira Itabashi, Yasushi Matsumoto, Teiji Tominaga

Brain and Nerve　61　(5)　581-589　2009/05

ISSN： 1881-6096
Incidence and risk factors for symptomatic cerebral hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in patients with moyamoya disease Peer-reviewed

Miki Fujimura, Shun Mugikura, Tomohiro Kaneta, Hiroaki Shimizu, Teiji Tominaga

SURGICAL NEUROLOGY　71　(4)　442-447　2009/04

DOI： 10.1016/j.surneu.2008.02.031 　

ISSN： 0090-3019
Acute ischemic complications after therapeutic parent artery occlusion with revascularization for complex internal carotid artery aneurysms Peer-reviewed

Kensuke Murakami, Hiroaki Shimizu, Yasushi Matsumoto, Teiji Tominaga

SURGICAL NEUROLOGY　71　(4)　434-441　2009/04

DOI： 10.1016/j.surneu.2008.03.036 　

ISSN： 0090-3019
Therapeutic efficacy of a polymeric micellar doxorubicin infused by convection-enhanced delivery against intracranial 9L brain tumor models Peer-reviewed

Tomoo Inoue, Yoji Yamashita, Masamichi Nishihara, Shinichiro Sugiyama, Yukihiko Sonoda, Toshihiro Kumabe, Masayuki Yokoyama, Teiji Tominaga

NEURO-ONCOLOGY　11　(2)　151-157　2009/04

DOI： 10.1215/15228517-2008-068 　

ISSN： 1522-8517
Cerebral ischemia owing to compression of the brain by swollen temporal muscle used for encephalo-myo-synangiosis in moyamoya disease Peer-reviewed

Miki Fujimura, Tomohiro Kaneta, Hiroaki Shimizu, Teiji Tominaga

NEUROSURGICAL REVIEW　32　(2)　245-249　2009/04

DOI： 10.1007/s10143-009-0184-6 　

ISSN： 0344-5607
Hemorrhagic onset of pilocytic astrocytoma and pilomyxoid astrocytoma Peer-reviewed

Ichiyo Shibahara, Masayuki Kanamori, Toshihiro Kumabe, Hidenori Endo, Yukihiko Sonoda, Yoshikazu Ogawa, Mika Watanabe, Teiji Tominaga

BRAIN TUMOR PATHOLOGY　26　(1)　1-5　2009/04

DOI： 10.1007/s10014-008-0243-7 　

ISSN： 1433-7398
Application of high-definition flexible neuroendoscopic system to the treatment of primary pineal malignant B-cell lymphoma Peer-reviewed

Hidenori Endo, Miki Fujimura, Toshihiro Kumabe, Masayuki Kanamori, Mika Watanabe, Teiji Tominaga

SURGICAL NEUROLOGY　71　(3)　344-348　2009/03

DOI： 10.1016/j.surneu.2007.08.029 　

ISSN： 0090-3019
Syringomyelia with obstructive hydrocephalus at the foramens of Luschka and Magendie successfully treated by endoscopic third ventriculostomy Peer-reviewed

Tomohiro Kawaguchi, Miki Fujimura, Teiji Tominaga

SURGICAL NEUROLOGY　71　(3)　349-352　2009/03

DOI： 10.1016/j.surneu.2007.08.015 　

ISSN： 0090-3019
[Neuroendoscopic management of a colloid cyst at the third ventricle using the high-definition flexible neuroendoscopic system: report of two cases]. Peer-reviewed

Kohama M, Fujimura M, Nagamatsu K, Murakami K, Tominaga T

No shinkei geka. Neurological surgery　37　(3)　261-267　2009/03

ISSN： 0301-2603
[Preoperative evaluation of the aneurismal wall by using high-resolution MRI: report of 3 cases]. Peer-reviewed

Sadahiro H, Shimizu H, Inoue T, Tominaga T

No shinkei geka. Neurological surgery　37　(3)　269-275　2009/03

ISSN： 0301-2603
[Surgical treatment of non-lesional supplementary motor area epilepsy: two case reports]. Peer-reviewed

Iwasaki M, Nakasato N, Shamoto H, Tominaga T

No shinkei geka. Neurological surgery　37　(3)　293-298　2009/03

ISSN： 0301-2603
Delayed intracerebral hemorrhage after superficial temporal artery-middle cerebral artery anastomosis in a patient with moyamoya disease: possible involvement of cerebral hyperperfusion and increased vascular permeability Peer-reviewed

Miki Fujimura, Hiroaki Shimizu, Shunji Mugikura, Teiji Tominaga

SURGICAL NEUROLOGY　71　(2)　223-227　2009/02

DOI： 10.1016/j.surneu.2007.07.077 　

ISSN： 0090-3019
Efficacy of the revascularization surgery for adult-onset moyamoya disease with the progression of cerebrovascular lesions Peer-reviewed

Ayumi Narisawa, Miki Fujimura, Teiji Tominaga

CLINICAL NEUROLOGY AND NEUROSURGERY　111　(2)　123-126　2009/02

DOI： 10.1016/j.clineuro.2008.09.022 　

ISSN： 0303-8467
[Primary yolk sac tumor in the cerebellar vermis. Case report]. Peer-reviewed

Nakamura T, Kanamori M, Sonoda Y, Watanabe M, Kumabe T, Tominaga T

No shinkei geka. Neurological surgery　37　(2)　173-177　2009/02

ISSN： 0301-2603
Neuro-endoscopic management of mesencephalic intraparenchymal cyst: a case report Peer-reviewed

Hidenori Endo, Miki Fujimura, Mika Watanabe, Teji Tominaga

SURGICAL NEUROLOGY　71　(1)　107-110　2009/01

DOI： 10.1016/j.surneu.2007.07.037 　

ISSN： 0090-3019
ADDITIONAL SURGERY FOR POSTOPERATIVE ISCHEMIC SYMPTOMS IN PATIENTS WITH MOYAMOYA DISEASE: THE EFFECTIVENESS OF OCCIPITAL ARTERY POSTERIOR CEREBRAL ARTERY BYPASS WITH AN INDIRECT PROCEDURE: TECHNICAL CASE REPORT Peer-reviewed

Toshiaki Hayashi, Reizo Shirane, Teiji Tominaga

NEUROSURGERY　64　(1)　195-196　2009/01

DOI： 10.1227/01.NEU.0000336311.60660.26 　

ISSN： 0148-396X
Intraoperative infrared brain surface blood flow monitoring during superficial temporal artery-middle cerebral artery anastomosis in patients with childhood moyamoya disease Peer-reviewed

Atsuhiro Nakagawa, Miki Fujimura, Tatsuhiko Arafune, Ichiro Sakuma, Teiji Tominaga

CHILDS NERVOUS SYSTEM　24　(11)　1299-1305　2008/11

DOI： 10.1007/s00381-008-0682-9 　

ISSN： 0256-7040
Enhanced antitumor effect of combined-modality treatment using convection-enhanced delivery of hydrophilic nitrosourea with irradiation or systemic administration of temozolomide in intracranial brain tumor xenografts Peer-reviewed

Shin-Ichiro Sugiyama, Yoji Yamashita, Toshio Kikuchi, Yukihiko Sonoda, Toshihiro Kumabe, Teiji Tominaga

NEUROLOGICAL RESEARCH　30　(9)　960-967　2008/11

DOI： 10.1179/174313208X331581 　

ISSN： 0161-6412
Convection-enhanced delivery of polyethylene glycol-coated liposomal doxorubicin: characterization and efficacy in rat intracranial glioma models Peer-reviewed

Toshio Kikuchi, Ryuta Saito, Shin-ichirou Sugiyama, Yoji Yamashita, Toshihiro Kumabe, Michal Krauze, Krystof Bankiewicz, Teiji Tominaga

JOURNAL OF NEUROSURGERY　109　(5)　867-873　2008/11

DOI： 10.3171/JNS/2008/109/11/0867 　

ISSN： 0022-3085
Papillary tumor of the pineal region: a case report Peer-reviewed

Tomoo Inoue, Toshihiro Kumabe, Masayuki Kanamori, Yukihiko Sonoda, Mika Watanabe, Teiji Tominaga

BRAIN TUMOR PATHOLOGY　25　(2)　85-90　2008/11

DOI： 10.1007/s10014-008-0231-y 　

ISSN： 1433-7398
[Clinical application of pulsed laser-induced liquid jet: preliminary report in glioma surgery]. Peer-reviewed

Nakagawa A, Kumabe T, Kanamori M, Saito R, Hirano T, Takayama K, Tominaga T

No shinkei geka. Neurological surgery　36　(11)　1005-1010　2008/11

ISSN： 0301-2603
Cerebral cavernous malformation - Its genetic and biological background Peer-reviewed

Miki Fujimura, Teiji Tominaga

Brain and Nerve　60　(11)　1271-1274　2008/11

ISSN： 1881-6096
Temporal change of 3-T magnetic resonance imaging/angiography during symptomatic cerebral hyperperfusion following superficial temporal artery-middle cerebral artery anastomosis in a patient with adult-onset moyamoya disease Peer-reviewed

Misaki Kohama, Miki Fujimura, Shunji Mugikura, Teiji Tominaga

NEUROSURGICAL REVIEW　31　(4)　451-455　2008/10

DOI： 10.1007/s10143-008-0147-3 　

ISSN： 0344-5607
Middle cerebral artery plaque imaging using 3-Tesla high-resolution MRI Peer-reviewed

Kuniyasu Nlizuma, Hiroaki Shimizu, Shihomi Takada, Teiji Tominaga

JOURNAL OF CLINICAL NEUROSCIENCE　15　(10)　1137-1141　2008/10

DOI： 10.1016/j.jocn.2007.09.024 　

ISSN： 0967-5868
Is histological diagnosis necessary to start treatment for germ cell tumours in the pineal region? Peer-reviewed

Masayuki Kanamori, Toshihiro Kumabe, Teiji Tominaga

JOURNAL OF CLINICAL NEUROSCIENCE　15　(9)　978-987　2008/09

DOI： 10.1016/j.jocn.2007.08.004 　

ISSN： 0967-5868
Functional MRI of the brain detects neuropathic pain in experimental spinal cord injury Peer-reviewed

Toshiki Endo, Christian Spenger, Jingxia Hao, Teiji Tominaga, Zsuzsanna Wiesenfeld-Hallin, Lars Olson, Xiao-Jun Xu

PAIN　138　(2)　292-300　2008/08

DOI： 10.1016/j.pain.2007.12.017 　

ISSN： 0304-3959
Germ cell tumors in the basal ganglia: problems of early diagnosis and treatment Peer-reviewed

Yukihiko Sonoda, Toshihiro Kumabe, Shin-Ichiro Sugiyama, Masayuki Kanamori, Yoji Yamashita, Ryuta Saito, Hisanori Ariga, Yoshihiro Takai, Teiji Tominaga

JOURNAL OF NEUROSURGERY-PEDIATRICS　2　(2)　118-124　2008/08

DOI： 10.3171/PED/2008/2/8/118 　

ISSN： 1933-0707
[Usefulness of human atrial natriuretic peptide in neurosurgical perioperative management]. Peer-reviewed

Kamii H, Sato K, Shimizu H, Fujiwara S, Tominaga T

No shinkei geka. Neurological surgery　36　(8)　687-692　2008/08

ISSN： 0301-2603
[Clinical features and significance of negative motor response in intraoperative language mapping during awake craniotomy]. Peer-reviewed

Nagamatsu K, Kumabe T, Suzuki K, Nakasato N, Sato K, Iizuka O, Kanamori M, Sonoda Y, Tominaga T

No shinkei geka. Neurological surgery　36　(8)　693-700　2008/08

ISSN： 0301-2603
[Glioblastoma multiforme developing separately from the initial lesion 9 years after successful treatment for gliomatosis cerebri: a case report]. Peer-reviewed

Inoue T, Kanamori M, Sonoda Y, Watanabe M, Sasajima T, Kamisato N, Kumabe T, Tominaga T

No shinkei geka. Neurological surgery　36　(8)　709-715　2008/08

ISSN： 0301-2603
Efficacy of superficial temporal artery-middle cerebral artery anastomosis with routine postoperative cerebral blood flow measurement during the acute stage in childhood moyamoya disease Peer-reviewed

Miki Fujimura, Tomohiro Kaneta, Teiji Tominaga

CHILDS NERVOUS SYSTEM　24　(7)　827-832　2008/07

DOI： 10.1007/s00381-007-0551-y 　

ISSN： 0256-7040
Efficacy of intraoperative wound irrigation for preventing shunt infection Peer-reviewed

Toshiaki Hayashi, Reizo Shirane, Takahiro Kato, Teiji Tominaga

JOURNAL OF NEUROSURGERY-PEDIATRICS　2　(1)　25-28　2008/07

DOI： 10.3777/PED/2008/2/7/025 　

ISSN： 1933-0707
[Multiple intracerebral enhanced lesions strongly suspected to be microsporidiosis. A case report]. Peer-reviewed

Okuyama H, Kanamori M, Watanabe M, Kumabe T, Tominaga T

No shinkei geka. Neurological surgery　36　(7)　645-650　2008/07

ISSN： 0301-2603
Neurosarcoidosis manifesting as tremor of the extremities and severe hypopituitarism: case report. Peer-reviewed

Ogawa Y, Tominaga T, Ikeda H

Neurologia medico-chirurgica　48　(7)　314-317　2008/07

DOI： 10.2176/nmc.48.314 　

ISSN： 0470-8105
Ischemic stroke due to dissection of intracranial internal carotid artery: implications for early surgical treatment Peer-reviewed

Funuaki Oka, Hiroaki Shimizu, Yasushi Matsumoto, Mika Watanabe, Teiji Tominaga

SURGICAL NEUROLOGY　69　(6)　578-585　2008/06

DOI： 10.1016/j.surneu.2007.04.002 　

ISSN： 0090-3019
Surgical treatment for choroid plexus tumors in the fourth ventricle: brain stem infiltration hinders total extirpation Peer-reviewed

Toshihiro Kumabe, Miki Fujimura, Hidefumi Jokura, Teiji Tominaga

NEUROSURGICAL REVIEW　31　(2)　165-172　2008/04

DOI： 10.1007/s10143-007-0103-7 　

ISSN： 0344-5607
Progressive moyamoya syndrome associated with de novo formation of the ipsilateral venous and contralateral cavernous malformations: case report Peer-reviewed

Elke Januschek, Miki Fujimura, Shunji Mugikura, Teiji Tominaga

SURGICAL NEUROLOGY　69　(4)　423-427　2008/04

DOI： 10.1016/j.sunreu.2007.01.078 　

ISSN： 0090-3019
Low-grade fibromyxoid sarcoma of intracranial origin Peer-reviewed

Ryuta Saito, Toshihiro Kumabe, Mika Watanabe, Hidefumi Jokura, Makoto Shibuya, Yoichi Nakazato, Teiji Tominaga

JOURNAL OF NEUROSURGERY　108　(4)　798-802　2008/04

DOI： 10.3171/JNS/2008/108/4/0798 　

ISSN： 0022-3085
Medulloblastoma demonstrating multipotent differentiation: case report Peer-reviewed

Hiroyuki Sakata, Masayuki Kanamori, Mika Watanabe, Toshihiro Kumabe, Teiji Tominaga

BRAIN TUMOR PATHOLOGY　25　(1)　39-43　2008/04

DOI： 10.1007/s10014-007-0228-y 　

ISSN： 1433-7398
A case of atypical thyrotroph cell adenoma, which re-grew within 3 months after surgery and required multimodal treatment Peer-reviewed

Yoshikazu Ogawa, Teiji Tominaga

JOURNAL OF NEURO-ONCOLOGY　87　(1)　91-95　2008/03

DOI： 10.1007/s11060-007-9492-2 　

ISSN： 0167-594X

eISSN： 1573-7373
Spinal granulocytic sarcoma manifesting as radiculopathy in a nonleukemic patient Peer-reviewed

Tomoo Inoue, Toshiyuki Takahashi, Hiroaki Shimizu, Masayuki Kanamori, Toshihiro Kumabe, Mika Watanabe, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　48　(3)　131-136　2008/03

DOI： 10.2176/nmc.48.131 　

ISSN： 0470-8105
Neurenteric cyst of the craniocervical junction in an infant Peer-reviewed

Hiroyuki Sakata, Miki Fujimura, Masaki Iwasaki, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　48　(2)　86-89　2008/02

DOI： 10.2176/nmc.48.86 　

ISSN： 0470-8105
Reorganization of sensory processing below the level of spinal cord injury as revealed by fMRl Peer-reviewed

Toshiki Endo, Christian Spenger, Eric Westman, Teiji Tominaga, Lars Olson

EXPERIMENTAL NEUROLOGY　209　(1)　155-160　2008/01

DOI： 10.1016/j.expneurol.2007.09.017 　

ISSN： 0014-4886
Intraoperative infrared brain surface blood flow monitoring during superficial temporal artery-middle cerebral artery anastomosis in a patient with moyamoya disease: clinical implication of the gradation value in postoperative clinical course--a case repo Peer-reviewed

Nakagawa A, Fujimura M, Arafune T, Suzuki H, Sakuma I, Tominaga T

Acta neurochirurgica. Supplement　102　159-163　2008

DOI： 10.1007/978-3-211-85578-2-32 　

ISSN： 0065-1419
Shock wave-induced brain injury in rat: novel traumatic brain injury animal model. Peer-reviewed

Nakagawa A, Fujimura M, Kato K, Okuyama H, Hashimoto T, Takayama K, Tominaga T

Acta neurochirurgica. Supplement　102　421-424　2008

DOI： 10.1007/978-3-211-85578-2-82 　

ISSN： 0065-1419
[Magnetic resonance angiographic occlusion of the cervical carotid artery at 3 tesla: its pitfalls]. Peer-reviewed

Mano Y, Shimizu H, Inoue T, Tominaga T

No shinkei geka. Neurological surgery　36　(1)　51-58　2008/01

ISSN： 0301-2603
Rapid revascularization after therapeutic parent artery occlusion for a large intracavernous carotid artery aneurysm. Peer-reviewed

Kagawa K, Shimizu H, Matsumoto Y, Watanabe M, Tominaga T

Neurologia medico-chirurgica　47　(12)　559-563　2007/12

DOI： 10.2176/nmc.47.559 　

ISSN： 0470-8105
Neuromagnetic localization of spike sources in perilesional, contralateral mirror, and ipsilateral remote areas in patients with cavernoma Peer-reviewed

Kazutaka Jin, Nobukazu Nakasato, Hiroshi Shamoto, Akitake Kanno, Yasuto Itoyama, Teiji Tominaga

EPILEPSIA　48　(11)　2160-2166　2007/11

DOI： 10.1111/j.1528-1167.2007.01228.x 　

ISSN： 0013-9580

eISSN： 1528-1167
Cortical sensory map rearrangement after spinal cord injury: fMRI responses linked to Nogo signalling Peer-reviewed

Toshiki Endo, Christian Spenger, Teiji Tominaga, Stefan Brene, Lars Olson

BRAIN　130　(Pt 11)　2951-2961　2007/11

DOI： 10.1093/brain/awm237 　

ISSN： 0006-8950
Association of cavernous malformation within vestibular schwannoma: immunohistochemical analysis of matrix metalloproteinase-2 and -9. Peer-reviewed

Sakata H, Fujimura M, Watanabe M, Tominaga T

Neurologia medico-chirurgica　47　(11)　509-512　2007/11

DOI： 10.2176/nmc.47.509 　

ISSN： 0470-8105
Symptomatic hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in a child with moyamoya disease Peer-reviewed

Miki Fujimura, Tomohiro Kaneta, Hiroaki Shimizu, Teiji Tominaga

CHILDS NERVOUS SYSTEM　23　(10)　1195-1198　2007/10

DOI： 10.1007/s00381-007-0361-2 　

ISSN： 0256-7040
Delayed cerebrospinal fluid leakage 10 years after transsphenoidal surgery and gamma knife surgery - case report - . Peer-reviewed

Ogawa Y, Tominaga T

Neurologia medico-chirurgica　47　(10)　483-485　2007/10

DOI： 10.2176/nmc.47.483 　

ISSN： 0470-8105
Intercostal arteriovenous fistula associated with neurofibromatosis manifesting as congestive myelopathy: case report. Peer-reviewed

Saito A, Takahashi T, Ezura M, Tominaga T

Neurosurgery　61　(3)　E656-7; discussion E657　2007/09

DOI： 10.1227/01.NEU.0000290918.47847.9E 　

ISSN： 0148-396X
A Randomized controlled trial of hydrocortisone against hyponatremia in patients with aneurysmal subarachnoid hemorrhage Peer-reviewed

Yoichi Katayama, Jo Haraoka, Hidehiro Hirabayashi, Tatsuro Kawamata, Keiji Kawamoto, Takao Kitahara, Jun Kojima, Toshihiko Kuroiwa, Tatsuro Mori, Nobuhiro Moro, Izumi Nagata, Akira Ogawa, Kikuo Ohno, Yoshikatsu Seiki, Yoshiaki Shiokawa, Akira Teramoto, Teiji Tominaga, Toshiki Yoshimine

STROKE　38　(8)　2373-2375　2007/08

DOI： 10.1161/STROKEAHA.106.480038 　

ISSN： 0039-2499
[Parent artery occlusion with bypass surgery for the treatment of aneurysms of the internal carotid artery]. Peer-reviewed

Shimizu H, Tominaga T

No shinkei geka. Neurological surgery　35　(8)　763-770　2007/08

ISSN： 0301-2603
[Intrasellar small TSH secreting pituitary adenomas, 2 case reports]. Peer-reviewed

Ogawa Y, Tominaga T, Ikeda H

No shinkei geka. Neurological surgery　35　(7)　679-684　2007/07

ISSN： 0301-2603
Anaplastic astrocytoma and anaplastic oligodendroglioma occurring 6 years after subtotal resection of a central neurocytoma - Case report Peer-reviewed

Masayuki Kanamori, Toshihiro Kumabe, Mika Watanabe, Teji Tominaga

JOURNAL OF NEUROSURGERY　107　(1)　185-189　2007/07

DOI： 10.3171/JNS-07/07/0185 　

ISSN： 0022-3085
[Seizure following superficial temporal-middle cerebral artery anastomosis in patients with moyamoya disease: possible contribution of postoperative cerebral hyperperfusion]. Peer-reviewed

Narisawa A, Fujimura M, Shimizu H, Tominaga T

No shinkei geka. Neurological surgery　35　(5)　467-474　2007/05

ISSN： 0301-2603
Total resection of a hemorrhagic tectal pilocytic astrocytoma - Case report Peer-reviewed

Fumiaki Oka, Yoji Yamashita, Toshihiro Kumabe, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　47　(5)　219-221　2007/05

DOI： 10.2176/nmc.47.219 　

ISSN： 0470-8105
Pressure-dependent effect of shock waves on rat brain: induction of neuronal apoptosis mediated by a caspase-dependent pathway Peer-reviewed

Kaoruko Kato, Miki Fujimura, Atsuhiro Nakagawa, Atsushi Saito, Tomohiro Ohki, Kazuyoshi Takayama, Teiji Tominaga

JOURNAL OF NEUROSURGERY　106　(4)　667-676　2007/04

DOI： 10.3171/jns.2007.106.4.667 　

ISSN： 0022-3085
Safety and efficacy of convection-enhanced delivery of ACNU, a hydrophilic nitrosourea, in intracranial brain tumor models Peer-reviewed

Shin-ichiro Sugiyama, Yoji Yamashita, Toshio Kikuchi, Ryuta Saito, Toshihiro Kumabe, Teiji Tominaga

JOURNAL OF NEURO-ONCOLOGY　82　(1)　41-47　2007/03

DOI： 10.1007/s11060-006-9247-5 　

ISSN： 0167-594X
Temporary neurologic deterioration due to cerebral hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in patients with adult-onset moyamoya disease Peer-reviewed

Miki Fujimura, Tomohiro Kaneta, Shunji Mugikura, Hiroaki Shimizu, Teiji Tominaga

SURGICAL NEUROLOGY　67　(3)　273-282　2007/03

DOI： 10.1016/j.surneu.2006.07.017 　

ISSN： 0090-3019
Clinicopathological and endocrinological study of Rathke's cleft cyst manifesting as hyponatremia. Peer-reviewed

Ogawa Y, Tominaga T, Ikeda H

Neurologia medico-chirurgica　47　(2)　58-63; discussion 63　2007/02

DOI： 10.2176/nmc.47.58 　

ISSN： 0470-8105
Ischemic complications associated with resection of opercular glioma Peer-reviewed

Toshihiro Kumabe, Shuichi Higano, Shoki Takahashi, Teiji Tominaga

JOURNAL OF NEUROSURGERY　106　(2)　263-269　2007/02

DOI： 10.3171/jns.2007.106.2.263 　

ISSN： 0022-3085
Spinal intramedullary metastasis of medulloblastoma at initial diagnosis Peer-reviewed

Tomoo Inoue, Toshihiro Kumabe, Toshiyuki Takahashi, Takeshi Nakajima, Mika Watanabe, Teiji Tominaga

CHILDS NERVOUS SYSTEM　23　(1)　113-116　2007/01

DOI： 10.1007/s00381-006-0167-7 　

ISSN： 0256-7040
[A case of cavernous angioma at the septum pellucidum]. Peer-reviewed

Narisawa A, Kumabe T, Anzai T, Utsumi Y, Tominaga T

No shinkei geka. Neurological surgery　35　(1)　53-58　2007/01

ISSN： 0301-2603
Surgical treatment of paraventricular cavernous angioma: fibre tracking for visualizing the corticospinal tract and determining surgical approach. Peer-reviewed

Niizuma K, Fujimura M, Kumabe T, Higano S, Tominaga T

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia　13　(10)　1028-1032　2006/12

DOI： 10.1016/j.jocn.2004.11.025 　

ISSN： 0967-5868
["Disease targeting therapy" for neurosurgical disorders: molecular targeting and drug delivery]. Peer-reviewed

Saito R, Kumabe T, Tominaga T

No shinkei geka. Neurological surgery　34　(11)　1157-1165　2006/11

ISSN： 0301-2603
Congestive myelopathy due to cervical perimedullary arteriovenous fistula evaluated by apparent diffusion coefficient values - Case report Peer-reviewed

Tomoo Inoue, Toshiyuki Takahashi, Hiroaki Shimizu, Yasushi Matsumoto, Akira Takahashi, Teiji Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　46　(11)　559-562　2006/11

DOI： 10.2176/nmc.46.559 　

ISSN： 0470-8105
[Diagnosis and various grading systems of subarachnoid hemorrhage]. Peer-reviewed

Shimizu H, Tominaga T

Nihon rinsho. Japanese journal of clinical medicine　64 Suppl 8　559-565　2006/11

ISSN： 0047-1852
[Delayed ischemic neurological deficit in patients with aneurysmal subarachnoid hemorrhage: its pathogenesis, prevention and treatment]. Peer-reviewed

Tominaga T, Fujimura M

Nihon rinsho. Japanese journal of clinical medicine　64 Suppl 8　650-653　2006/11

ISSN： 0047-1852
[Cerebral cavernous malformation]. Peer-reviewed

Fujimura M, Tominaga T

Nihon rinsho. Japanese journal of clinical medicine　64 Suppl 8　691-694　2006/11

ISSN： 0047-1852
[Intraoperative brain surface blood flow monitoring using IRIS V thermographic imaging system in patients with Moyamoya disease]. Peer-reviewed

Nakagawa A, Fujimura M, Ohki T, Suzuki H, Takayama K, Tominaga T

No shinkei geka. Neurological surgery　34　(10)　1017-1025　2006/10

ISSN： 0301-2603
Penetrating atheroma in cervical carotid artery stenosis. Peer-reviewed

Narisawa A, Shimizu H, Watanabe M, Tominaga T

Neurologia medico-chirurgica　46　(9)　434-437　2006/09

DOI： 10.2176/nmc.46.434 　

ISSN： 0470-8105
[Diagnostic value of perfusion-weighted MRI for evaluating postoperative alteration of cerebral hemodynamics following STA-MCA anastomosis in patients with moyamoya disease]. Peer-reviewed

Fujimura M, Mugikura S, Shimizu H, Tominaga T

No shinkei geka. Neurological surgery　34　(8)　801-809　2006/08

ISSN： 0301-2603
[Usefulness of regional cerebral oxygen saturation monitoring in balloon test occlusion]. Peer-reviewed

Niizuma K, Kamii H, Matsumoto Y, Kondoh R, Shimizu H, Tominaga T

No shinkei geka. Neurological surgery　34　(7)　695-702　2006/07

ISSN： 0301-2603
[Precocious puberty caused by hCG-producing germinoma involving the bilateral basal ganglia and cerebral white matter without 1ypical radiologic findings: case report]. Peer-reviewed

Sugiyama S, Kumabe T, Mino M, Fujimura M, Fujiwara I, Tominaga T

No shinkei geka. Neurological surgery　34　(6)　619-624　2006/06

ISSN： 0301-2603
[Intracerebral intravascular papillary endothelial hyperplasia mimicking a metastatic brain tumor: a case report]. Peer-reviewed

Yamashita Y, Kumabe T, Tominaga T, Watanabe M

No to shinkei = Brain and nerve　58　(4)　344-345　2006/04

ISSN： 0006-8969
Evaluation of interhemispheric time difference by magnetoencephalography before and after total callosotomy - Two case reports Peer-reviewed

KA Salayev, N Nakasato, M Ishitobi, H Shamoto, A Kanno, T Tominaga, K Iinuma

NEUROLOGIA MEDICO-CHIRURGICA　46　(3)　136-142　2006/03

DOI： 10.2176/nmc.46.136 　

ISSN： 0470-8105
De novo and salvage pathways of DNA synthesis non primary cultured neurall stem cells Peer-reviewed

K Sato, J Kanno, T Tominaga, Y Matsubara, S Kure

BRAIN RESEARCH　1071　(1)　24-33　2006/02

DOI： 10.1016/j.brainres.2005.11.039 　

ISSN： 0006-8993
[Choroid plexus tumors: report of 7 cases in a single institution]. Peer-reviewed

Noshita N, Kumabe T, Kayama T, Tominaga T

No shinkei geka. Neurological surgery　34　(1)　73-81　2006/01

ISSN： 0301-2603
Attenuation of fluctuating striatal synaptic dopamine levels in patients with Parkinson disease in response to subthalamic nucleus stimulation: a positron emission tomography study Peer-reviewed

T Nimura, K Yamaguchi, T Ando, S Shibuya, T Oikawa, A Nakagawa, R Shirane, M Itoh, T Tominaga

JOURNAL OF NEUROSURGERY　103　(6)　968-973　2005/12

DOI： 10.3171/jns.2005.103.6.0968 　

ISSN： 0022-3085
The relationship among p53 oligomer formation, structure and transcriptional activity using a comprehensive missense mutation library Peer-reviewed

T Kawaguchi, S Kato, K Otsuka, G Watanabe, T Kumabe, T Tominaga, T Yoshimoto, C Ishioka

ONCOGENE　24　(46)　6976-6981　2005/10

DOI： 10.1038/sj.onc.1208839 　

ISSN： 0950-9232
[Preoperative functional brain mapping using magnetoencephalography for brain tumors]. Peer-reviewed

Nobukazu Nakasato, Toshihiro Kumabe, Teiji Tominaga

Nihon rinsho. Japanese journal of clinical medicine　63 Suppl 9　228-35　2005/09

ISSN： 0047-1852
[Progress in prognosis for patients with gliomas]. Peer-reviewed

Kumabe T, Tominaga T

Nihon rinsho. Japanese journal of clinical medicine　63 Suppl 9　293-297　2005/09

ISSN： 0047-1852
[Relationship between intraoperative brain mapping and pre- or post-operative functional MRI in patients with glioma]. Peer-reviewed

Karibe H, Kumabe T, Tominaga T

Nihon rinsho. Japanese journal of clinical medicine　63 Suppl 9　395-400　2005/09

ISSN： 0047-1852
Fronto-basal interhemispheric approach for craniopharyngiomas extending outside the suprasellar cistern Peer-reviewed

R Shirane, T Hayashi, T Tominaga

CHILDS NERVOUS SYSTEM　21　(8-9)　669-678　2005/08

DOI： 10.1007/s00381-005-1206-5 　

ISSN： 0256-7040
Paraparesis associated with ruptured anterior cerebral artery territory aneurysms Peer-reviewed

H Endo, H Shimizu, T Tominaga

SURGICAL NEUROLOGY　64　(2)　135-139　2005/08

DOI： 10.1016/j.surneu.2004.12.019 　

ISSN： 0090-3019
Transethmoidal intranasal meningoencephalocele in an adult with recurrent meningitis Peer-reviewed

T Hasegawa, N Sugeno, Y Shiga, A Takeda, H Karibe, T Tominaga, Y Itoyama

JOURNAL OF CLINICAL NEUROSCIENCE　12　(6)　702-704　2005/08

DOI： 10.1016/j.jocn.2004.08.027 　

ISSN： 0967-5868
Spinal cord infarction demonstrated by diffusion-weighted magnetic resonance imaging Peer-reviewed

M Shinoyama, T Takahashi, H Shimizu, T Tominaga, M Suzuki

JOURNAL OF CLINICAL NEUROSCIENCE　12　(4)　466-468　2005/05

DOI： 10.1016/j.jocn.2004.01.010 　

ISSN： 0967-5868
Tl-201-SPECT and H-1-MRS study of benign lateral ventricle tumors: differential diagnosis of subependymoma Peer-reviewed

T Kawaguchi, T Kumabe, H Shimizu, M Watanabe, T Tominaga

NEUROSURGICAL REVIEW　28　(2)　96-103　2005/04

DOI： 10.1007/s10143-004-0353-6 　

ISSN： 0344-5607
Neuromagnetic measurement of unilateral temporo-parietal theta rhythm in patients with internal carotid artery occlusive disease Peer-reviewed

S Seki, N Nakasato, S Ohtomo, A Kanno, H Shimizu, T Tominaga

NEUROIMAGE　25　(2)　502-510　2005/04

DOI： 10.1016/j.neuroimage.2004.11.025 　

ISSN： 1053-8119
Neuromagnetic evaluation of binaural unmasking Peer-reviewed

T Sasaki, T Kawase, N Nakasato, A Kanno, M Ogura, T Tominaga, T Kobayashi

NEUROIMAGE　25　(3)　684-689　2005/04

DOI： 10.1016/j.neuroimage.2004.11.030 　

ISSN： 1053-8119
Ectopic recurrence of craniopharyngioma Peer-reviewed

T Kawaguchi, M Fujimura, R Shirane, T Shoji, M Watanabe, T Tominaga

JOURNAL OF CLINICAL NEUROSCIENCE　12　(3)　307-309　2005/04

DOI： 10.1016/j.jocn.2004.01.009 　

ISSN： 0967-5868
Delayed lymphocytic infundibuloneurohypo-physitis following successful transsphenoidal treatment of Cushing's disease Peer-reviewed

T Kawaguchi, H Ikeda, M Fujimura, T Yoshimoto, T Tominaga

JOURNAL OF CLINICAL NEUROSCIENCE　12　(3)　320-323　2005/04

DOI： 10.1016/j.jocn.2004.04.007 　

ISSN： 0967-5868
[MRA volume rendering for surgical planning of unruptured intracranial cerebral aneurysms]. Peer-reviewed

Narisawa A, Syamoto H, Karibe H, Shimizu H, Fujiwara S, Tominaga T

No shinkei geka. Neurological surgery　33　(3)　243-248　2005/03

ISSN： 0301-2603
[Surgical removal of gliomas with attention to preserve vascular structures]. Peer-reviewed

Kumabe T, Tominaga T

No shinkei geka. Neurological surgery　33　(1)　19-27　2005/01

ISSN： 0301-2603
Diagnostic value of super-selective bilateral cavernous sinus sampling with hypothalamic stimulating hormone loading in patients with ACTH-producing pituitary adenoma Peer-reviewed

M Fujimura, H Ikeda, A Takahashi, M Ezura, T Yoshimoto, T Tominaga

NEUROLOGICAL RESEARCH　27　(1)　11-15　2005/01

DOI： 10.1179/016164105X18106 　

ISSN： 0161-6412
Neuroprotective role of neurotrophins: Relationship between nerve growth factor and apoptotic cell survival pathway after cerebral ischemia Peer-reviewed

Atsushi Saito, Teiji Tominaga, Pak H. Chan

Current Atherosclerosis Reports　7　(4)　268-273　2005
Publisher: Current Science Ltd
DOI： 10.1007/s11883-005-0018-0 　

ISSN： 1523-3804
Neuroprotective effect of an antioxidant in ischemic brain injury - Involvement of neuronal apoptosis Peer-reviewed

M Fujimura, T Tominaga, PH Chan

NEUROCRITICAL CARE　2　(1)　59-66　2005

DOI： 10.1385/NCC:2:1:059 　

ISSN： 1541-6933
Thoracic intradural arachnoid cyst associated with surgical removal of epidural hematoma - Case report Peer-reviewed

H Endo, T Takahashi, H Shimizu, T Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　44　(11)　607-610　2004/11

DOI： 10.2176/nmc.44.607 　

ISSN： 0470-8105
Computational replicas: Anatomic reconstructions of cerebral vessels as volume numerical grids at three-dimensional angiography Peer-reviewed

T Hassan, EV Timofeev, T Saito, H Shimizu, M Ezura, T Tominaga, A Takahashi, K Takayama

AMERICAN JOURNAL OF NEURORADIOLOGY　25　(8)　1356-1365　2004/09

ISSN： 0195-6108
Hydrocephalus due to cerebrospinal fluid overproduction by bilateral choroid plexus papillomas Peer-reviewed

M Fujimura, T Onuma, M Kameyama, O Motohashi, H Kon, K Yamamoto, K Ishii, T Tominaga

CHILDS NERVOUS SYSTEM　20　(7)　485-488　2004/07

DOI： 10.1007/s00381-003-0889-8 　

ISSN： 0256-7040
Comparison of magnetoencephalographic spikes with and without concurrent electroencephalographic spikes in extratemporal epilepsy Peer-reviewed

HM Park, N Nakasato, M Iwasaki, H Shamoto, T Tominaga, T Yoshimoto

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　203　(3)　165-174　2004/07

DOI： 10.1620/tjem.203.165 　

ISSN： 0040-8727

eISSN： 1349-3329
Pulsed holmium : yttrium-aluminum-garnet laser-induced liquid jet as a novel dissection device in neuroendoscopic surgery Peer-reviewed

A Nakagawa, T Hirano, H Jokura, H Uenohara, T Ohki, T Hashimoto, Menezes, V, Y Sato, Y Kusaka, H Ohyama, T Saito, K Takayama, R Shirane, T Tominaga

JOURNAL OF NEUROSURGERY　101　(1)　145-150　2004/07

DOI： 10.3171/jns.2004.101.1.0145 　

ISSN： 0022-3085
Intramedullary spinal tuberculoma - Case report Peer-reviewed

H Torii, T Takahashi, H Shimizu, M Watanabe, T Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　44　(5)　266-268　2004/05

DOI： 10.2176/nmc.44.266 　

ISSN： 0470-8105
The role of sigma-receptors in levodopa-induced dyskinesia in patients with advanced Parkinson disease: a positron emission tomography study Peer-reviewed

T Nimura, T Ando, K Yamaguchi, T Nakajima, R Shirane, M Itoh, T Tominaga

JOURNAL OF NEUROSURGERY　100　(4)　606-610　2004/04

DOI： 10.3171/jns.2004.100.4.0606 　

ISSN： 0022-3085
Exclusively extradural arteriovenous malformation with neurogenic claudication. Case illustration. Peer-reviewed

Niizuma K, Fujimura M, Takahashi T, Takahashi A, Watanabe M, Tominaga T

Journal of neurosurgery　100　(4 Suppl Spine)　397　2004/04

ISSN： 0022-3085
Spontaneous regression of a primary cerebral tumor following vasospasm caused by subarachnoid hemorrhage due to rupture of an intracranial aneurysm - Case report Peer-reviewed

Y Yamashita, T Kumabe, H Shimizu, M Ezura, T Tominaga

NEUROLOGIA MEDICO-CHIRURGICA　44　(4)　187-190　2004/04

DOI： 10.2176/nmc.44.187 　

ISSN： 0470-8105
[Clinical feature and surgical treatment of spontaneous spinal epidural hematoma]. Peer-reviewed

Kimiwada T, Takahashi T, Shimizu H, Tominaga T

No shinkei geka. Neurological surgery　32　(4)　333-338　2004/04

ISSN： 0301-2603
Dissection of the superior cerebellar artery: a report of two cases and review of the literature Peer-reviewed

H Gotoh, T Takahashi, H Shimizu, M Ezura, T Tominaga

JOURNAL OF CLINICAL NEUROSCIENCE　11　(2)　196-199　2004/02

DOI： 10.1016/S0967-5868(03)00136-X 　

ISSN： 0967-5868
Computational simulation of therapeutic parent artery occlusion to treat giant vertebrobasilar aneurysm Peer-reviewed

T Hassan, M Ezura, EV Timofeev, T Tominaga, T Saito, A Takahashi, K Takayama, T Yoshimoto

AMERICAN JOURNAL OF NEURORADIOLOGY　25　(1)　63-68　2004/01

ISSN： 0195-6108
Intractable vomiting as an early clinical symptom of cerebrospinal fluid seeding to the fourth ventricle in patients with high-grade astrocytoma Peer-reviewed

M Fujimura, T Kumabe, H Jokura, R Shirane, T Yoshimoto, T Tominaga

JOURNAL OF NEURO-ONCOLOGY　66　(1-2)　209-216　2004/01

DOI： 10.1023/B:NEON.0000013487.71148.5d 　

ISSN： 0167-594X
Experimental application of pulsed Ho : YAG laser-induced liquid jet as a novel rigid neuroendoscopic dissection device Peer-reviewed

T Ohki, A Nakagawa, T Hirano, T Hashimoto, Menezes, V, H Jokura, H Uenohara, Y Sato, T Saito, R Shirane, T Tominaga, K Takayama

LASERS IN SURGERY AND MEDICINE　34　(3)　227-234　2004

DOI： 10.1002/lsm.20021 　

ISSN： 0196-8092
Lipomatous meningioma of the brain harboring metastatic renal-cell carcinoma: A case report Peer-reviewed

Tomomi Kimiwada, Osamu Motohashi, Toshihiro Kumabe, Mika Watanabe, Teiji Tominaga

Brain Tumor Pathology　21　(1)　47-52　2004

DOI： 10.1007/BF02482177 　

ISSN： 1433-7398
A Case of Hyperemia during Arteriovenous Malformation Surgery Controlled with β-blocker and Jugular Bulb Oxygen Saturation (SjO2) Monitoring Peer-reviewed

Tomomi Kimiwada, Hideyuki Kamii, Teiji Tominaga, Masato Kato

Japanese Journal of Anesthesiology　52　(10)　1074-1078　2003/10

ISSN： 0021-4892
[Functional brain mapping using evoked potentials and magnetic fields: basic knowledge of clinical nerve physiology for neurosurgeons]. Peer-reviewed

Nakasato N, Shamoto H, Nakasato N, Kanno A, Ryogo T, Kumabe T, Tominaga T

No shinkei geka. Neurological surgery　31　(9)　1030-1037　2003/09

ISSN： 0301-2603
Cervical cord compression with myelopathy caused by bilateral persistence of the first intersegmental arteries: case report. Peer-reviewed

Takahashi T, Tominaga T, Hassan T, Yoshimoto T

Neurosurgery　53　(1)　234-7; discussion 237　2003/07

ISSN： 0148-396X
Selective loss of Purkinje cells in transverse and sigmoid dural arteriovenous fistulas - Report of two cases Peer-reviewed

T Tominaga, H Shamoto, H Shimizu, M Watanabe, T Yoshimoto

JOURNAL OF NEUROSURGERY　98　(3)　617-620　2003/03

DOI： 10.3171/jns.2003.98.3.0617 　

ISSN： 0022-3085
[Transient hyperintensity lesions on diffusion-weighted MRI in the bilateral internal capsules due to hypoglycemic coma]. Peer-reviewed

Endo H, Shimizu H, Tominaga T, Yoshimoto T

No to shinkei = Brain and nerve　55　(2)　174-175　2003/02

ISSN： 0006-8969
Amlodipine Lowers Blood Pressure without Significant Effect on Cerebral Blood Flow in Hypertensive Patients with a History of Stroke: A Quantitative Single Photon Emission Computed Tomography Study Peer-reviewed

Hiroaki Shimizu, Teiji Tominaga, Satoru Fujiwara

Journal of Stroke and Cerebrovascular Diseases　12　(6)　266-270　2003
Publisher: W.B. Saunders
DOI： 10.1016/j.jstrokecerebrovasdis.2003.09.009 　

ISSN： 1052-3057
Rotational vertebral artery occlusion from occipital bone anomaly: a rare cause of embolic stroke - Case report Peer-reviewed

T Tominaga, T Takahashi, H Shimizu, T Yoshimoto

JOURNAL OF NEUROSURGERY　97　(6)　1456-1459　2002/12

DOI： 10.3171/jns.2002.97.6.1456 　

ISSN： 0022-3085
Hypoglossal neurinoma presenting with intratumoral hemorrhage Peer-reviewed

T Takahashi, T Tominaga, Y Sato, M Watanabe, T Yoshimoto

JOURNAL OF CLINICAL NEUROSCIENCE　9　(6)　716-719　2002/11

DOI： 10.1054/jocn.2001.1109 　

ISSN： 0967-5868
Intraoperative angiography to prevent vertebral artery injury during reduction of a dislocated hangman fracture - Case report Peer-reviewed

T Takahashi, T Tominaga, M Ezura, K Sato, T Yoshimoto

JOURNAL OF NEUROSURGERY　97　(3)　355-358　2002/10

ISSN： 0022-3085
Use of cerebrovascular reactivity in patients with symptomatic major cerebral artery occlusion to predict 5-year outcome: Comparison of xenon-133 and iodine-123-IMP single-photon emission computed tomography Peer-reviewed

K Ogasawara, A Ogawa, K Terasaki, H Shimizu, T Tominaga, T Yoshimoto

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　22　(9)　1142-1148　2002/09

DOI： 10.1097/00004647-200209000-00012 　

ISSN： 0271-678X
Seizure-induced thoracic spine compression fracture: case report. Peer-reviewed

Takahashi T, Tominaga T, Shamoto H, Shimizu H, Yoshimoto T

Surgical neurology　58　(3-4)　214-6; discussion 216　2002/09

DOI： 10.1016/S0090-3019(02)00837-6 　

ISSN： 0090-3019
Fatal subarachnoid hemorrhage, with brainstem and cerebellar infarction, caused by Aspergillus infection after cerebral aneurysm surgery: case report. Peer-reviewed

Endo T, Tominaga T, Konno H, Yoshimoto T

Neurosurgery　50　(5)　1147-50; discussion 1150　2002/05

DOI： 10.1097/00006123-200205000-00039 　

ISSN： 0148-396X
Quantitative assessment of surgical decompression of the cervical spine with cine phase contrast magnetic resonance imaging. Peer-reviewed

Tominaga T, Watabe N, Takahashi T, Shimizu H, Yoshimoto T

Neurosurgery　50　(4)　791-5; discussion 796　2002/04

DOI： 10.1097/00006123-200204000-00020 　

ISSN： 0148-396X
Bypass surgery for occluded internal carotid artery revascularized by vasa vasorum - Case report Peer-reviewed

H Shimizu, T Tominaga, M Ezura, T Yoshimoto

NEUROLOGIA MEDICO-CHIRURGICA　42　(2)　57-61　2002/02

DOI： 10.2176/nmc.42.57 　

ISSN： 0470-8105

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Books and Other Publications 3

Neurovascular Imaging

Takahashi Shoki ed, Kumabe Toshihiro, Saito Ryuta, Kanamori Masayuki, Sonoda Yukihiko, Higano Shuichi, Takahashi Shoki, Tominaga Teiji

Springer　2010/05
Neurovascular Imaging

Takahashi Shoki ed, Kumabe Toshihiro, Kanamori Masayuki, Saito Ryuta, Nagamatsu Ken-ichi, Sonoda Yukihiko, Higano Shuichi, Takahashi Shoki, Tominaga Teiji

Springer　2010/04
Moyamoya Disease Update

Byung-Kyu Cho, Teiji Tominaga eds

Springer　2009/03

Presentations 189

脳脊髄血管奇形の外科治療

冨永悌二

Acute Iｓchemic Stroke講演会　2012/03/24
疾風に勁草を知る

冨永悌二

総合南東北病院 Medical Conference　2012/03/13
流体科学と脳血管障害

冨永悌二

Brain Vascular Care Conference　2012/03/09
東北大学脳神経外科：疾風に勁草を知る

冨永悌二

京都脳神経外科セミナー 2012　2012/02/11
宮城県の医療復興の展望

冨永悌二

第5回石巻脳神経外科座談会　2011/12/27
脳神経外科における新たな薬物送達法

冨永悌二

第240回山梨脳神経外科セミナー　2011/11/10
もやもや病 up date

冨永悌二

奈良脳神経外科カンファレンス　2011/10/28
比較的希な脳梗塞の原因疾患と治療

冨永悌二

第25回かずさ脳血管障害談話会　2011/09/30
脊髄血管障害の外科治療

冨永悌二

第11回北関東脊髄外科研究会　2011/09/16
悪性脳腫瘍に対する新たな治療-CED

冨永悌二

第26回日本神経外科全国野球大会神経外科セミナー　2011/08/31
被災地最前線における脳卒中治療

冨永悌二

Stoke 2011　2011/07/30
もやもや病 up date

冨永悌二

第6回Miyagi Sennan Stroke Conference　2011/07/26
脳動脈奇形の複合治療

冨永悌二

第15回脳血管外科治療セミナー　2011/07/01
脳動脈奇形の複合治療

冨永悌二

第15回脳血管外科治療セミナー・イブニングセミナー　2011/07/01
lessons learned from Moyamoya disease International-presentation

冨永悌二

アジアもやもや病カンファレンス　2011/06/02
Current topics on AVM treatment in Sendai International-presentation

冨永悌二

Tohoku-Yonsei Joint Symposium on Cerebrovascular Surgery　2011/05/28
脳脊髄血管奇形の病態と治療

冨永悌二

第7回東北脳卒中診断治療研究会　2011/03/11
脳・脊髄血管奇形の外科治療

冨永悌二

第48回愛媛脳神経外科懇話会　2011/02/18
薬剤の脳内注入：新たな治療法の開発

冨永悌二

第4回石巻脳神経外科座談会　2010/12/08
脳・脊髄血管奇形の外科治療

冨永悌二

第14回KNC脳疾患研究会　2010/11/27
Moyamoya Disease:Update International-presentation

冨永悌二

The 38th Annual Meeting of the International Society for Pediatric Neurosurgery　2010/10/30
Onyxによる脳動脈奇形の外科摘出前塞栓術

冨永悌二

第69回社団法人日本脳神経外科学会総会　2010/10/27
動静脈奇形の外科治療

冨永悌二

第69回福島県脳神経談話会　2010/10/20
・

冨永悌二

山梨脳血管障害研究会 2010　2010/10/05
脳脊髄血管奇形の外科治療

冨永悌二

第24回中国地方脳神経外科手術研究会　2010/08/21
脳・脊髄血管奇形の外科治療

冨永悌二

第12回徳島脳血管障害カンファレンス　2010/05/29
もやもや病に対する直接・間接血行再建術と周術期管理の工夫

冨永悌二

第1回北のまほろば脳神経外科手術研究会　2010/05/28
切除に拠らないてんかんの外科治療：Convection enhanced delivery(CED) for the treatment of epilepsy

冨永悌二

第42回奈良エピレプシークラブ　2010/05/14
脳脊髄血管奇形の最善の治療（AVMにおける血管内外科治療）

冨永悌二

第30回日本脳神経外科コングレス　2010/05/07
特別講演

冨永悌二

第33回香川脳血管障害研究会　2010/04/02
Multimodality management of AVM International-presentation

冨永悌二

35th The Annual Meeting of Egyptian Society of Neurological Surgeons　2010/03/10
脳・脊髄血管奇形の外科治療

冨永悌二

第18回河田町脳神経外科懇話会　2010/03/06
気になる心臓、脳、呼吸の病気：脳梗塞の治療最前線

冨永悌二

第2回元気！健康！フェア　2010/02/27
脳動静脈奇形の外科治療

冨永悌二

第46回大分県脳卒中懇話会　2010/02/13
脊髄AVMの一手術例

冨永悌二

第10回東北脊髄外科研究会　2010/02/05
脳動静脈奇形の外科治療

冨永悌二

第2回石巻脳神経外科座談会　2009/12/10
無症候性血管障害の外科治療

冨永悌二

第3回大阪脳血管障害研究会　2009/11/14
Surgical managemnet of intracerebral AVMs, Surgical management of intracerebral AVMs in a Multimodality team International-presentation

冨永悌二

第9回国際脳卒中学会　2009/11/12
動静脈奇形：最近経験した興味ある症例から

冨永悌二

秋田ブレインアタック研究会　2009/11/06
特別講演 2

冨永悌二

第11回みやぎブレインアタック研究会　2009/10/02
Convection enhanced delivery方ー基礎研究から臨床応用までー

冨永悌二

第1回松島カンファレンス　2009/07/30
特別講演

冨永悌二

第13回宮城県脳ドック研究会　2009/07/21
Moyamoya Disease:Update International-presentation

冨永悌二

Department of Neurological Surgery -Grand Rounds(MGRXX036)-　2009/07/09
Surgical Management of Cervical Perimodullary AVF International-presentation

冨永悌二

The 7th Biennial Japan-Korea Conference on Spinal Surgery　2009/07/01
脳卒中を予防し、治そう

冨永悌二

第50回日本神経学会総会市民公開講座　2009/05/23
脊椎血管奇形の外科治療

冨永悌二

第24回TKNJ Conference　2009/05/23
Surgical managemnet of intracerebral AVMs, Surgical management of intracerebral AVF International-presentation

冨永悌二

The 27th Annual Spring Meeting of the Korean Neurosurgical Society　2009/04/16
頭蓋内動静脈瘻の外科治療

冨永悌二

第34回日本脳卒中学会総会・第38回日本脳卒中の外科学会・第25回スパズムシンポジウム　2009/03/20
脳卒中の診断と治療〜最近のトピック

冨永悌二

総合南東北病院Medical Conference　2009/02/19
脊髄疾患の外科治療：最近の経験

冨永悌二

第14回奈良脊髄外科研究会　2009/02/16
クモ膜下出血の稀な原因？脊髄血管性障害の外科治療

冨永悌二

第8回名古屋脳卒中外科研究会学術集会　2009/02/09
脳卒中の救急に関して

冨永悌二

平成20年度日本医師会生涯教育講座・救急医療医師研究会　2008/11/29
脊髄血管奇形の外科治療

冨永悌二

第31回岩手脳神経外科談話会、第18回ハイテクリサーチセンター講演会　2008/10/31
悪性神経膠腫に対する新たな治療展開ーConvection -enhanced delivery 法の臨床導入

冨永悌二

第67回日本脳神経外科学会総会　2008/10/02
脊髄血管性障害の外科治療

冨永悌二

第54回鹿児島脳神経外科学会　2008/08/02
AVM多角的治療の諸問題

冨永悌二

第6回北海道ストロークフォーラム　2008/06/21
硬膜AVFの診断と治療

冨永悌二

山梨脳血管障害研究会　2008/06/20
Surgical management of moyamoya disease:Recent advance International-presentation

冨永悌二

The 9th Japanese and Korean Friendship Conference on Surgery for Cerbral Stroke　2008/06/07
脳卒中の外科治療：最近のトピック

冨永悌二

Shiga Neurosurgical Forum　2008/05/23
脳卒中の診断と治療〜最近のトピック

冨永悌二

総合南東北病院Medical Conference　2008/02/19
脊髄疾患の外科治療：最近の経験

冨永悌二

第14回奈良脊髄外科研究会　2008/02/16
くも膜下出血の稀な原因ー脊髄血管性障害の外科治療

冨永悌二

第8回名古屋脳卒中外科研究会学術集会　2008/02/09
Anaplastic ependymoma の治療成績

齋藤竜太, 隈部俊宏, 金森政之, 園田順彦, 冨永悌二

第25回日本脳腫瘍学会　2007/12/09
Diffuse astrocytoma の長期治療成績

金森政之, 園田順彦, 渡辺みか, 隈部俊宏, 冨永悌二

第25回日本脳腫瘍学会　2007/12/09
膠芽腫長期生存例の解析

園田順彦, 渡辺みか, 井上智夫, 金森政之, 隈部俊宏, 冨永悌二

第25回日本脳腫瘍学会　2007/12/09
再発germinoma に対する治療

隈部俊宏, 金森政之, 園田順彦, 高井良尋, 冨永悌二

第25回日本脳腫瘍学会　2007/12/09
悪性神経膠腫に発生した肺塞栓症

山下洋二, 川口奉洋, 金森政之, 園田順彦, 隈部俊宏, 渡辺みか, 冨永悌二

第25回日本脳腫瘍学会　2007/12/09
脳卒中の外科治療：最近のトピック

冨永悌二

第5回Kyushu CVD Conference　2007/12/01
軟性鏡を用いた内視鏡的第三脳出開窓術の治療成績についての検討

藤村幹, 城倉英史, 隈部俊宏, 冨永悌二

第14回日本神経内視鏡学会　2007/12/01
頭蓋咽頭腫に対する内視鏡支援下拡大経蝶形骨洞手術

小川欣一, 清水宏明, 藤原悟, 冨永悌二

第14回日本神経内視鏡学会　2007/12/01
軟性神経内視鏡を用いて治療したcolloid cystの2例

小濱みさき, 藤村幹, 永松謙一, 村上謙介, 冨永悌二

第14回日本神経内視鏡学会　2007/12/01
脳卒中の外科治療ー最近のTopic

冨永悌二

第19回山形県対脳卒中治療研究会　2007/11/24
New insight into Myoyamoya disease

冨永悌二

Suzuki Jiro Memorial Conference on Neurosurgery　2007/11/23
Surgical management of spinal vascular malformation International-presentation

冨永悌二

12th Asian Australasian Congress of Neurological Surgeons　2007/11/18
Radical surgical resection of insulo-opercular gliomas International-presentation

Toshihiro Kumabe, Teiji Tominaga

World Federation of Neurosurgical Societies, 13th Interim Meeting /The 12th Asian-Australasian Congress of Neurological Surgeons　2007/11/18
Efficacy of endoscopic third ventriculostomy using flexible neuroendoscopic system: outcome of 46 consecutive cases in Tohoku University

Miki Fujimura, Hidefumi Jokura, Toshihiro Kumabe, Teiji Tominaga

World Federation of Neurosurgical Societies, 13th Interim Meeting /The 12th Asian-Australasian Congress of Neurological Surgeons　2007/11/18
Surgica management of spinal vascular malformations International-presentation

冨永悌二

第4回上海国際脳神経外科学会、第2回国際脳出血学会　2007/11/09
最大摘出と細血管温存の両立を目的としたレーザージェットメスの開発：悪性神経膠腫4例の経験を踏まえて

隈部俊宏, 中川敦寛, 金森政之, 渡辺みか, 斉藤竜太, 平野孝幸, 佐々木健吾, 高山和喜, 冨永悌二

第12回日本脳腫瘍の外科学会　2007/11/02
ガンマナイフ治療後に外科治療を行った神経鞘腫の検討

村上謙介, 藤村幹, 渡辺みか, 川岸潤, 城倉英史, 冨永悌二

第12回日本脳腫瘍の外科学会　2007/11/02
再発頭蓋咽頭腫の手術

白根礼造, 林俊哲, 加藤貴弘, 冨永悌二

第12回日本脳腫瘍の外科学会　2007/11/02
視機能温存を目的とした脳磁図と白質線維描出統合情報の有用性

園田順彦, 隈部俊宏, 中里信和, 井上敬, 高田志保美, 金森政之, 冨永悌二

第12回日本脳腫瘍の外科学会　2007/11/02
Anaplastic ependymomaの治療成績

齋藤竜太, 隈部俊宏, 金森政之, 園田順彦, 冨永悌二

第12回日本脳腫瘍の外科学会　2007/11/02
脳神経外科手術における細血管温存下切開デバイスの開発：臨床経験をふまえて

冨永悌二

第66回社団法人日本脳神経外科学会総会　2007/10/03
安全で最大限の摘出を目指すglioma 手術の基本手技

隈部俊宏, 冨永悌二

第66回社団法人日本脳神経外科学会総会　2007/10/03
もやもや病に対するSTA-MCA吻合術後・症候性過灌流とその関連因子についての検討

藤村幹, 清水宏明, 冨永悌二

第66回日本脳神経外科学会総会　2007/10/03
Diffuse astrocytomaの長期治療成績

金森政之, 園田順彦, 渡辺みか, 隈部俊宏, 冨永悌二

第66回社団法人日本脳神経外科学会総会　2007/10/03
Glioblastomaの長期生存症例の検討

園田順彦, 井上智夫, 渡辺みか, 金森政之, 隈部俊宏, 冨永悌二

第66回社団法人日本脳神経外科学会総会　2007/10/03
神経膠腫症18症例の臨床的検討

井上智夫, 隈部俊宏, 金森政之, 渡辺みか, 園田順彦, 冨永悌二

第66回社団法人日本脳神経外科学会総会　2007/10/03
WHO grade ？,？髄膜腫の治療

村上謙介, 藤村幹, 隈部俊宏, 城倉英史, 冨永悌二

第66回社団法人日本脳神経外科学会総会　2007/10/03
小児悪性脳腫瘍の休眠状態の存在

永松謙一, 金森政之, 斉藤竜太, 山下洋二, 井上智夫, 園田順彦, 隈部俊宏, 冨永悌二

第66回社団法人日本脳神経外科学会総会　2007/10/03
感度波長域7-14μmの赤外線画像開頭術中モニタリング：適応と術中〜術後急性期管理における臨床的意義

中川敦寛, 藤村幹, 荒船龍彦, 山口喬弘, 清水宏明, 佐久間一郎, 冨永悌二

第66回社団法人日本脳神経外科学会総会　2007/10/03
Clinical Features of Malignant Glioneuronal Tumors-5 cases report

佐藤健一, 金森政之, 渡辺みか, 隈部俊宏, 冨永悌二

第66回社団法人日本脳神経外科学会総会　2007/10/03
正常カニクイザルにおけるConvection-Enhanced Delivery法によって投与されたACNUの薬剤分布と安全性の評価

山下洋二, 杉山慎一郎, 井上智夫, 園田順彦, 隈部俊宏, 冨永悌二

第66回社団法人日本脳神経外科学会総会　2007/10/03
甲状腺機能亢進症を合併した（類）もやもや病手術例の検討：周術期管理と術後急性期脳循環動態について

遠藤英徳, 藤村幹, 冨永悌二

第66回社団法人日本脳神経外科学会総会　2007/10/03
もやもや病・病期進行例に対する血行再建術についての検討

成澤あゆみ, 藤村幹, 冨永悌二

第66回社団法人日本脳神経外科学会総会　2007/10/03
もやもや病に対する直接血行再建術後急性期の病態について：3-Tesla MRI を用いた検討

小濱みさき, 藤村幹, 麦倉俊司, 冨永悌二

第66回社団法人日本脳神経外科学会総会　2007/10/03
ラット脳腫瘍モデルにおける対流強化輸送法を用いた局所化学療法とテモゾロミド全身投与との併用効果

杉山慎一郎, 山下洋二, 菊池登志雄, 齋藤竜太, 園田順彦, 隈部俊宏, 冨永悌二

第66回社団法人日本脳神経外科学会総会　2007/10/02
ジストニアに対し両側淡蒼球茂樹術が有効であった二例

永松謙一, 冨永悌二, 安藤肇史, 大友智, 木村格

第81回日本神経学会東北地方会　2007/09/08
症候性過灌流を呈した成人出血発症もやもや病の1 例：3-Tesla MRI による診断

小濱みさき, 藤村幹, 冨永悌二

第43 回（社）日本脳神経外科学会東北地方会　2007/09/08
片麻痺を伴うくも膜下出血症例における術中motor evoked potential(MEP)モニタリング

中村太源, 岩崎真樹, 清水宏明, 社本博, 上井英之, 佐藤清貴, 藤原悟, 冨永悌二

第43 回（社）日本脳神経外科学会東北地方会　2007/09/08
経過観察中に解離が進行した若年性内頚動脈解離の1 例

加藤貴弘, 林俊哲, 白根礼造, 冨永悌二

第43 回（社）日本脳神経外科学会東北地方会　2007/09/08
脳表ヘモジデリン沈着症で発症した脊髄腫瘍の一例

君和田友美, 村上謙介, 永松謙一, 隈部俊宏, 冨永悌二, 渡辺みか

第43 回（社）日本脳神経外科学会東北地方会　2007/09/08
Foramen magnum syndrome を呈したdumbbell type C2 神経鞘腫の一例

園部真也, 村上謙介, 小濱みさき, 隈部俊宏, 冨永悌二, 渡辺みか

第43 回（社）日本脳神経外科学会東北地方会　2007/09/08
軟性神経内視鏡を用いて治療した症候性透明中隔嚢胞の一例

西嶌泰生, 藤村幹, 小濱みさき, 冨永悌二

第43 回（社）日本脳神経外科学会東北地方会　2007/09/08
細血管温存と神経膠腫最大摘出の両立を目的としたレーザージェットメスの開発

中川敦寛, 隈部俊宏, 金森政之, 平野孝幸, 佐々木健吾, 斉藤竜太, 冨永悌二, 渡辺みか, 高山和喜

第43 回（社）日本脳神経外科学会東北地方会　2007/09/08
多発性骨転移を来した膠芽腫の一例

菊池登志雄, 隈部俊宏, 金森政之, 園田順彦, 冨永悌二, 渡辺みか

第43 回（社）日本脳神経外科学会東北地方会　2007/09/08
鞍底へ下方牽引された視交叉に対し、経蝶形骨洞的な直接剥離を要した下垂体腺腫の一例

小川欣一, 清水宏明, 藤原悟, 冨永悌二

第43 回（社）日本脳神経外科学会東北地方会　2007/09/08
Papillary tumor of the pineal region の1 例

井上智夫, 隈部俊宏, 金森政之, 園田順彦, 冨永悌二, 渡辺みか

第43 回（社）日本脳神経外科学会東北地方会　2007/09/08
『洗浄法』によるシャント感染予防

林俊哲, 加藤貴弘, 白根礼造, 冨永悌二

第43 回（社）日本脳神経外科学会東北地方会　2007/09/08
衝撃波による脳組織損傷：圧損傷閾値の同定と損傷機序に関する検討

中川敦寛, 藤村幹, 加藤薫子, 奥山洋信, 斉藤敦志, 高山和喜, 冨永悌二

第8回日本分子脳神経外科学会　2007/08/31
膠芽腫の増殖におけるNotch signalingの役割に関する検討

金森政之, 川口奉洋, Nigro JM, Feuerstein BG, Berger MS, Miele L, 隈部俊宏, 冨永悌二, Pieper RO

第8回日本分子脳神経外科学会　2007/08/31
もやもや病患者末梢血における制御型T細胞関連マーカー（CD4/25, Foxp3）の検討

藤村幹, 藤村卓, 相場節也, 冨永悌二

第8回日本分子脳神経外科学会　2007/08/31
脊髄損傷後の脳一次体性感覚野ReorganizationとNogo受容体の関連: 機能MRIによる検討

遠藤俊毅, 藤村幹, Lars Olson, 冨永悌二

第8回日本分子脳神経外科学会　2007/08/31
神経膠腫摘出術における細血管温存下切開デバイスの開発

中川敦寛, 隈部俊宏, 金森政之, 斉藤竜太, 佐々木健吾, 平野孝幸, 高山和喜, 冨永悌二

第26回日本脳神経超音波学会　2007/07/09
衝撃波による脳神経組織損傷？閾値と機序に関する検討？

加藤薫子, 藤村幹, 中川敦寛, 斉藤敦志, 奥山洋信, 高山和喜, 冨永悌二

第26回日本脳神経超音波学会　2007/07/09
脳表ヘモジデリン沈着症で発症した脊髄腫瘍の一例

君和田友美, 村上謙介, 永松謙一, 隈部俊宏, 冨永悌二, 渡辺みか

第7回東北脊髄外科研究会　2007/07/06
Intraoperative Brain Surface Monitoring Using Infrared Imaging in Patients with Moyamoya Disease International-presentation

Atsuhiro Nakagawa, Teiji Tominaga, Ichiro Sakuma, Etsuko Kobayashi, Tatsuhiko Arafune, Miki Fujimura

13th International Symposium on Intracranial Pressure and Brain Monitoring　2007/06/22
Shock Wave Induced Brain Injury: Pathological Evaluation Using Rat Model International-presentation

Atsuhiro Nakagawa, Teiji Tominaga, Kazuyoshi Takayama, Hironobu Okuyama, Kaoruko Kato, Miki Fujimura

13th International Symposium on Intracranial Pressure and Brain Monitoring　2007/06/22
定位放射線治療の合併症

城倉英史, 川岸潤, 冨永悌二

第27回日本脳神経外科コングレス総会　2007/05/18
頭蓋咽頭腫に対する安全で確実なsurgical radicality

白根礼造, 林俊昭, 冨永悌二

第16回脳神経外科手術と機器学会　2007/04/12
頭蓋咽頭腫に対する経鼻的アプローチの摘出限界と工夫

池田秀敏, 冨永悌二

第16回脳神経外科手術と機器学会　2007/04/12
軟性鏡による内視鏡的第三脳室開窓術の治療成績

藤村幹, 隈部俊宏, 冨永悌二, 城倉英史

第16回脳神経外科手術と機器学会　2007/04/12
Convection-Enhanced Delivery法によるACNU投与と放射線療法あるいはtemozolomide全身投与との併用療法

山下洋二, 杉山慎一郎, 菊池登志雄, 金森政之, 隈部俊宏, 冨永悌二

第16回脳神経外科手術と機器学会　2007/04/12
神経膠腫摘出術における細血管温存を目的とした新規脳腫瘍切開デバイスの開発

中川敦寛, 隈部俊宏, 金森政之, 斉藤竜太, 佐々木健吾, 平野孝幸, 冨永悌二, 高山和喜

第16回脳神経外科手術と機器学会　2007/04/12
5-ALAによる術中蛍光診断と病理組織像の検討

金森政之, 齋藤竜太, 隈部俊宏, 冨永悌二, 渡辺みか

第16回脳神経外科手術と機器学会　2007/04/12
穿通枝描出における3.0 Tesla MRIの有用性

隈部俊宏, 高田志保美, 新妻邦泰, 山下洋二, 金森政之, 冨永悌二

第16回脳神経外科手術と機器学会　2007/04/12
脳卒中の急性期診断と治療

冨永悌二, 清水宏明

第36回日本脳卒中の外科学会　2007/03/22
当科における髄芽腫の治療成績

隈部俊宏, 金森政之, 冨永悌二, 林俊哲, 白根礼造

第29回東北小児がん研究会　2007/03/17
硬膜下血腫で発症した乳児虐待

林俊哲, 白根礼造, 冨永悌二

第30回日本神経外傷学会　2007/03/16
くも膜下出血急性期脳損傷：SOD1過剰発現による酸化ストレス減少とAkt/GSK3β生存シグナル活性化の影響

遠藤英徳, 藤村幹, 冨永悌二, チャン・パク

第30回日本神経外傷学会　2007/03/16
衝撃波による脳神経組織損傷の閾値および機序の解明：Caspase依存性経路によるアポトーシスの検討

加藤薫子, 藤村幹, 中川敦寛, 斉藤敦志, 冨永悌二, 大木友博, 高山和喜

第30回日本神経外傷学会　2007/03/16
乳児虐待による急性硬膜下血腫？15年間における臨床像の変化？

刈部博, 小沼武英, 亀山元信, 平野孝幸, 加藤薫子, 冨永悌二

第30回日本神経外傷学会　2007/03/16
MRA及び頚動脈エコーにて頚部頚動脈閉塞が疑われたがCEAが可能であった2手術例

坂田洋之, 清水宏明, 岩崎真樹, 藤原悟, 冨永悌二

第42回(社)日本脳神経外科学会東北地方会　2007/03/10
初期治療８年後に小脳虫部に膠芽腫を形成した神経膠腫症の１症例

井上智夫, 金森政之, 隈部俊宏, 冨永悌二, 渡辺みか, 笹嶋寿郎, 神里信夫

第42回(社)日本脳神経外科学会東北地方会　2007/03/10
パーキンソン病のジスキネジアに対する手術効果

安藤肇史, 大友智, 冨永悌二

第42回(社)日本脳神経外科学会東北地方会　2007/03/10
Ｃ-11 methionine PET が病変の活動性評価に有用であった小児身分化腫瘍の１例

金森政之, 隈部俊宏, 冨永悌二, 渡辺みか, 中里洋一, 田代学, 伊藤正敏

第42回(社)日本脳神経外科学会東北地方会　2007/03/10
軟性鏡を用いた内視鏡的第３脳室空窓術の治療成績

藤村幹, 隈部俊宏, 冨永悌二, 城倉英史

第42回(社)日本脳神経外科学会東北地方会　2007/03/10
5-ALAによる術中蛍光診断と病理組織像の検討

金森政之, 斎藤竜太, 隈部俊宏, 冨永悌二, 渡辺みか

第3回日本脳神経外科光線力学研究会　2007/02/24
多発性脳神経播腫を伴った松果体部悪性リンパ腫の一例

遠藤英徳, 藤村幹, 隈部俊宏, 金森政之, 冨永悌二

第42回(社)日本脳神経外科学会東北地方会　2007/02/10
島・弁蓋部神経膠腫手術に伴う問題点：血管障害を中心に

隈部俊宏, 金森政之, 冨永悌二, 日向野修一, 高橋昭喜

第36回日本神経放射線学会　2007/02/08
Telovelar（transcerebellomedullary fissure）approachを用いた第４脳室及び脳幹部腫瘍摘出術

隈部俊宏, 金森政之, 冨永悌二

第11回日本脳腫瘍の外科学会　2006/12/08
神経膠腫摘出中完全覚醒維持による言語機能温存

永松謙一, 隈部俊宏, 金森政之, 冨永悌二, 鈴木匡子, 中里信和, 佐藤清貴

第4回日本 Awake Surgery 研究会　2006/12/07
Collaboration of microsurgery and endovascular surgery in the treatment of cerebral aneurysms: its benefit and pitfall International-presentation

Teiji Tominaga, Hiroaki Shimizu, Akira Takahashi

8th International Conference on Cerebrovascular Surgery　2006/11/30
Collabpration of microsurgery and endovascular surgery International-presentation

Tominaga Teiji

Collabpration of The 8th International Conference on　2006/11/30
神経系への分化を示す小型異型細胞群を含有した

佐藤健一, 金森政之, 隈部俊宏, 冨永悌二, 渡辺みか

第１３回東北神経病理研究会　2006/11/25
Anaplastic oligodendrogliomaとgangliocytomaの

渡辺みか, 佐藤健一, 金森政之, 隈部俊宏, 冨永悌二

第１３回東北神経病理研究会　2006/11/25
脊髄空洞症を伴う水頭症に対し第三脳室開窓術が

藤村幹, 川口奉洋, 冨永悌二, 高橋敏行, 清水宏明, 藤原悟

第１３回日本神経内視鏡学会　2006/11/17
覚醒下脳機能マッピング導入後１０年間の治療経験

永松謙一, 隈部俊宏, 冨永悌二, 鈴木匡子, 佐藤清貴, 中里信和

第６５回社団法人日本脳神経外科学会総会　2006/10/18
頭蓋咽頭腫に対する経頭蓋手術

白根礼造, 林俊哲, 冨永悌二

第６５回社団法人日本脳神経外科学会総会　2006/10/18
無症候性髄膜腫に対するガンマナイフ治療の長期成績

城倉英史, 川岸潤, 須貝和幸, 高橋康, 冨永悌二

第６５回社団法人日本脳神経外科学会総会　2006/10/18
脳動静脈奇形に対するガンマナイフ治療の長期治療成績

川岸潤, 城倉英史, 高橋康, 須貝和幸, 冨永悌二

第６５回社団法人日本脳神経外科学会総会　2006/10/18
ラトケ嚢胞の臨床的およびMRI所見の検討？短期間に経験した多彩な症候を持つラトケ嚢胞症例の解析より？

井上智夫, 池田秀敏, 小川欣一, 冨永悌二

第６５回社団法人日本脳神経外科学会総会　2006/10/18
乳児虐待による急性硬膜下血腫

刈部博, 小沼武英, 亀山元信, 平野孝幸, 中川敦寛, 冨永悌二

第６５回社団法人日本脳神経外科学会総会　2006/10/18
ＡＣＮＵを基本化学療法剤とした膠芽腫の治療成績

隈部俊宏, 金森政之, 冨永悌二

第65回脳神経外科学会総会　2006/10/18
内頚動脈瘤に対するバイパス＋親動脈閉塞術の長期成績

清水宏明, 社本博, 藤原悟, 松本康史, 冨永悌二

第65回脳神経外科学会総会　2006/10/18
脳腫瘍診断における見かけ上の拡散係数測定の有用性

山下洋二, 隈部俊宏, 金森政之, 菊池登志雄, 冨永悌二, 日向野修一, 渡辺みか

第65回脳神経外科学会総会　2006/10/18
頸髄動静脈奇形の診断と治療成績

高橋敏行, 清水宏明, 藤原悟, 松本康史, 江面正幸, 高橋明, 冨永悌二

第65回脳神経外科学会総会　2006/10/18
欠突起膠腫における予後規定因子に関する検討

金森政之, 齋藤竜太, 山下洋二, 隈部俊宏, 冨永悌二, 渡辺みか

第65回脳神経外科学会総会　2006/10/18
パーキンソン病に対する両側視床下核刺激術の

安藤肇史, 大友智, 冨永悌二, 永松謙一

第65回脳神経外科学会総会　2006/10/18
tumstatinによるインテグリンα？β３依存性腫瘍増殖抑制効果におけるＰＴＥＮ／Ａｋｔ経路の役割について

川口奉洋, 山下洋二, 金森政之, 隈部俊宏, 冨永悌二, Krystof Bankiewicz, Gabriele Bergers、Russell Pieper

第65回脳神経外科学会総会　2006/10/18
Drug carrierを用いたConvection？enhanced delivery：新規脳腫瘍治療法の開発

齋藤竜太, 山下洋二, 隈部俊宏, 冨永悌二, バーガーミッチェル, バンキービッツクリス, パークジョン

第65回脳神経外科学会総会　2006/10/18
Convection？Enhanced Delivery法を用いたＡＣＮＵ投与の安全性と効果

杉山慎一郎, 山下洋二, 菊池登志雄, 齋藤竜太, 隈部俊宏, 冨永悌二

第65回脳神経外科学会総会　2006/10/18
ＣＥＤ法を用いた薬剤局所投与と放射線治療の併用による

菊池登志雄, 齋藤竜太, 山下洋二, 杉山慎一郎, 隈部俊宏, 冨永悌二

第65回脳神経外科学会総会　2006/10/18
脊髄脂肪腫術後脊髄係留症候群の手術治療

林俊哲, 白根礼造, 冨永悌二

第65回脳神経外科学会総会　2006/10/18
微小血管温存を目的とした新規脳腫瘍切開デバイスの開発

中川敦寛, 隈部俊宏, 金森政之, 齋藤竜太, 平野孝之, 冨永悌二, 高山和喜

第65回脳神経外科学会総会　2006/10/18
虚血性海馬ＣＡ１神経細胞死における

遠藤英徳, 藤村幹, 冨永悌二, チャンパク

第65回脳神経外科学会総会　2006/10/18
モヤモヤ病に対する血行再建術前後の脳循環と臨床像：

藤村幹, 中川敦寛, 冨永悌二, 麦倉俊司, 金田朋洋, 清水宏明

第65回脳神経外科学会総会　2006/10/18
モヤモヤ病血行再建術後の痙攣：術後局所過灌流との

成澤あゆみ, 藤村幹, 冨永悌二, 清水宏明

第65回脳神経外科学会総会　2006/10/18
Diagnostic value of perfusion-weighted MRI for evaluating postoperative alteration of cerebral hemodynamics in patients with moyamoya disease International-presentation

Fujimura M, Mugikura S, SHimizu H, Tominaga T

Congress of Neurological Surgeons,　2006/10/07
乏突起膠腫における予後規定因子に関する検

金森政之, 齋藤竜太, 山下洋二, 隈部俊宏, 冨永悌二, 渡辺みか

第24回日本脳腫瘍学会　2006/10/01
頭蓋内微小環境におけるintegrin a？β3発現の

金森政之, 齋藤竜太, 山下洋二, 隈部俊宏, 冨永悌二, 渡辺みか

第24回日本脳腫瘍学会　2006/10/01
Convection？Enhanced Delivery法を用いたACNU脳内局所投与の安全性と効果

山下洋二, 杉山慎一郎, 齋藤竜太, 菊池登志雄, 金森政之, 隈部俊宏, 冨永悌二

第24回日本脳腫瘍学会　2006/10/01
基底核胚細胞腫瘍の臨床的特徴

杉山慎一郎, 山下洋二, 金森政之, 齋藤竜太, 隈部俊宏, 冨永悌二

第24回日本脳腫瘍学会　2006/10/01
当科における髄芽腫の治療成績

隈部俊宏, 金森政之, 山下洋二, 冨永悌二, 林俊哲, 白根礼造

第24回日本脳腫瘍学会　2006/10/01
くも膜下出血急性期脳損傷におけるAkt/GSK3β生存シグナルの役割

遠藤英徳, 藤村幹, チャンパク, 冨永悌二

第７回日本分子脳神経外科学会　2006/09/02
Symptomatic cerebral hyperperfusion following International-presentation

Fujimura M, Kaneta T, Narisawa A, Tominaga T

The 8th Korean and Japanese Friendship Conference　2006/08/05
脊髄血管障害の診断と治療

冨永悌二

東北脊髄外科研究会　2006/07/14
CLINICAL CHARACTERISTICS OF GERM CELL TUMORS ORIGINATING IN THE BASAL GANGLIA International-presentation

Shin-ichiro Sugiyama, Yoji Yamashita, Masayuki Kanamori, Ryuta Saito, Toshihiro Kumabe, Teiji Tominaga

１２ｔｈ International Symposium on Pediatric Neuro-Oncology ２００６　2006/06/06
PRERADIATION CHEMOTHERAPY FOR MALIGNANT BRAIN TUMOR PATIENTS YOUNGER THAN 3 YEARS OLD : EXPERIENCE WITH 10 CONSECTIVE CASES International-presentation

Kuniyasu Niizuma, Toshihiro Kumabe, Ryuta Saito, Masayuki Kanamori, Reizo Shirane, Teiji Tominaga

１２ｔｈ International Symposium on Pediatric Neuro-Oncology ２００６　2006/06/06
頚部頚動脈狭窄診断上の問題点：ＣＥＡ適応との関連で

清水宏明, 藤原悟, 冨永悌二

第３０回北日本脳神経外科連合会学術集会　2006/06/01
髄芽腫における見かけ上の拡散係数測定の意義

山下洋二, 隈部俊宏, 金森政之, 冨永悌二, 日向野修一, 渡辺みか

第３０回北日本脳神経外科連合会学術集会　2006/06/01
基底核部胚細胞腫の臨床的特徴

杉山慎一郎, 齋藤竜太, 金森政之, 山下洋二, 隈部俊宏, 冨永悌二

第３０回北日本脳神経外科連合会学術集会　2006/06/01
幼児期に発症した頭蓋頚椎移行部のNeuroenteric cystの一手術例

坂田洋之, 藤村幹, 岩崎真樹, 冨永悌二

第３０回北日本脳神経外科連合会学術集会　2006/06/01
脊髄播種に対し積極的治療を施行し長期生存しえた悪性神経膠腫の一例

佐藤健一, 隈部俊宏, 冨永悌二, 高橋敏行, 渡辺みか

第２１回日本脊髄外科学会　2006/05/25
Ischemic complications caused by resection of opercular gliomas International-presentation

Kumabe Toshihiro, Higano S, Takashi S, Tominaga T

１６ｔｈ Biennial International Brain Tumor Research and Therapy Meeting　2006/04/26
小児頭蓋咽頭腫の治療と問題点

白根礼造, 林俊哲, 冨永悌二

第２８回東北小児がん研究会　2006/03/04
神経膠腫摘出における５―アミノレブリン酸（5-ALA）及び紫色半導体レーザー装置を用いた蛍光診断の有用性

隈部俊宏, 齋藤竜太, 金森政之, 冨永悌二, 渡辺みか

第２回日本脳神経外科光線力学研究会　2006/02/04
fiber trackingを用いた白質線維描出の問題点

新妻邦泰, 隈部俊宏, 冨永悌二, 日向野修一, 高橋昭喜

第２９回日本脳神経ＣＩ学会総会　2006/01/27
赤外線画像システムIRIS Ｖを用いたもやもや病血行再建術中脳表モニタリング：術後経過との相関に関する検討

藤村幹, 冨永悌二, 清水宏明, 高山和喜

第３０回北日本脳神経外科連合会学術集会　2005/06/01

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Social Activities 2

[日本国内] 財団法人広南会広南病院

2007/05 -

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[日本国内] 財団法人宮城県対脳卒中協会

2004/07/06 -

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Media Coverage 3

[日本国内] なるほど健康雑学東北大リレー講座 45

河北新報

2007/05/28

Type: Newspaper, magazine

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脳の手術の発展：神経学の発達が貢献
[日本国内] なるほど健康雑学東北大リレー講座 44

河北

2007/05/21

Type: Newspaper, magazine

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多様化する脳神経外科治療：長所・短所勘案し選択
[日本国内] なるほど健康雑学東北大リレー講座 43

河北新報

2007/05/14

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脳梗塞治療の新局面について：早期治療で症状改善

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神経・血管温存下に最大級の病変摘出を伴う手術用治療器（パルスウォータジェットメス）の開発

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神経・血管温存下に最大級の病変摘出を伴う手術用治療器（パルスウォータジェットメス）の開発
ウィリス動脈輪閉塞症の診断・治療に関する研究

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ウィリス動脈輪閉塞症の診断と治療に関する研究
標準治療抵抗性神経膠芽腫に対するペプチドワクチンの第ＩＩＩ相臨床研究

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標準治療抵抗性神経膠芽腫に対するペプチドワクチンの第ＩＩＩ相臨床研究
学術動向の調査研究

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学術動向の調査研究
最大限の病変摘出と機能温存を両立するパルスジェットメスの開発

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最大限の病変摘出と機能温存を両立するパルスジェットメスの開発
高齢者重症頭部外傷集中治療における二次侵襲モニタリングとquality assuranceシステムの構築

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高齢者重症頭部外傷集中治療における二次侵襲モニタリングとquality assuranceシステムの構築
流体ジェットの医用応用に関する基礎研究

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流体ジェットの医用応用に関する基礎研究
放射線による認知機能障害を回避する転移性脳腫瘍の治療法に関する研究

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放射線による認知機能障害を回避する転移性脳腫瘍の治療法に関する研究
ウィリス動脈輪閉塞症における生体試料の収集に関する研究

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ウィリス動脈輪閉塞症における生体試料の収集に関する研究
非もやもや病小児閉塞性脳血管障害の実態把握と治療指針に関する研究

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非もやもや病小児閉塞性脳血管障害の実態把握と治療指針に関する研究
脳内対流の解析による脳局所投薬技術の改良

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脳内対流の解析による脳局所投薬技術の改良
脳梗塞急性期における抗血小板薬の有効性に関する研究

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脳梗塞急性期における抗血小板薬の有効性に関する研究
ウィリス動脈輪閉塞症の診断・治療に関する研究

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ウィリス動脈輪閉塞症の診断・治療に関する研究
高分子ミセルのconvection-enhanced法による抗がん活性評価

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高分子ミセルのconvection-enhanced法による抗がん活性評価
高次脳機能を温存する転移性脳腫瘍の治療法確立に関する研究

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高次脳機能を温存する転移性脳腫瘍の治療法確立に関する研究
脳卒中ネットワークのためのソフトウェアの開発

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脳卒中ネットワークのためのソフトウェアの開発
ウィリス動脈輪閉塞症における病態・治療に関する研究

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ウィリス動脈輪閉塞症における病態・治療に関する研究
正常圧水頭症と関連疾患の病因・病態と治療に関する研究

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正常圧水頭症と関連疾患の病因・病態と治療に関する研究
内頚動脈閉塞症に伴う血行力学的脳梗塞の発症予防に関する研究

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内頚動脈閉塞症に伴う血行力学的脳梗塞の発症予防に関する研究
転移性脳腫瘍に対する標準的治療法確立に関する研究

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転移性脳腫瘍に対する標準的治療法確立に関する研究

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