Details of the Researcher

PHOTO

Satoshi Mizuno
Section
Tohoku Medical Megabank Organization
Job title
Senior Assistant Professor
Degree

  • Ph.d (Tohoku University)

  • M.A. (Tokyo Medical and Dental University)

  • B.A. (Tokyo University of Agriculture)

Research History 4

  • 2024/04 - Present
    Tohoku University　Tohoku Medical Megabank Organization

  • 2017/10 - 2024/03
    Tohoku University　Tohoku Medical Megabank Organization

  • 2015/08 - 2017/09
    Tohoku University　Tohoku Medical Megabank Organization

  • 2012/07 - 2015/07
    Tohoku University　Graduate School of Medicine

Research Interests 3

  • 妊娠高血圧症候群

  • 医療情報学

  • バイオインフォマティクス

Research Areas 1

  • Informatics / Biological, health, and medical informatics /

Papers 52

  1. Paternal bonding failure and depression at 1 month postpartum are associated with neurodevelopmental delay in 4-year-old children: An Adjunct Study of the Japan Environment and Children's Study. International-journal

    Hidekazu Nishigori, Toshie Nishigori, Taku Obara, Kasumi Sakurai, Mami Ishikuro, Satoshi Mizuno, Zen Watanabe, Masatoshi Saito, Chiharu Ota, Takahiro Arima, Hirohito Metoki, Shinichi Kuriyama, Nobuo Yaegashi

    Infant mental health journal　47　(3)　e70082　2026/05

    DOI： 10.1002/imhj.70082 　

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    We aimed to determine the association between paternal bonding failure and depression in the postpartum period and children's neurodevelopment, as an Adjunct Study of the Japan Environment and Children's Study (JECS), a prospective cohort study. We evaluated the association between the Japanese version of the Mother-to-Infant Bonding Scale (MIBS) / Edinburgh Postnatal Depression Scale (EPDS) scores for fathers and the Ages and Stages Questionnaires, Third Edition (ASQ-3) scores in their 4-year-old children. Paternal MIBS and EPDS were administered at 1 month postpartum. Data from 646 father-child pairs were analyzed using multivariate logistic regression analyses. Paternal MIBS total scores ≥5 were associated with communication (adjusted odds ratio [AOR], 2.786; 95% confidence interval [CI], 1.088-7.132), problem-solving (AOR, 3.136; 95% CI, 1.027-9.574), and personal-social delays (AOR, 2.843; 95% CI, 1.353-5.978) (reference, scores ≤2). Paternal EPDS scores ≥8 were associated with fine motor (AOR, 3.315; 95% CI, 1.470-7.473) and problem-solving delays (AOR, 4.904; 95% CI, 1.664-14.446) (reference, scores ≤7). Bonding failure and depression at 1 month postpartum in fathers are associated with neurodevelopmental delays in their 4-year-old children, with different domain-specific patterns.

  2. Cohort Profile Update: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) 2023 update. International-journal

    Taku Obara, Mami Ishikuro, Aoi Noda, Keiko Murakami, Masatsugu Orui, Genki Shinoda, Fumihiko Ueno, Fumiko Matsuzaki, Tomomi Onuma, Hiroko Matsubara, Hirohito Metoki, Masahiro Kikuya, Rieko Hatanaka, Ippei Chiba, Kumi Nakaya, Mana Kogure, Naoki Nakaya, Junichi Sugawara, Shigeo Kure, Mika Kobayashi, Tomoko Kobayashi, Yoichi Suzuki, Hiroshi Kawame, Mika Sakurai-Yageta, Sachiko Nagase, Naoki Nakamura, Tomohiro Nakamura, Satoshi Mizuno, Satoshi Nagaie, Soichi Ogishima, Akira Narita, Gen Tamiya, Sachie Koreeda, Fuji Nagami, Toru Tamahara, Maki Goto, Akihito Otsuki, Makiko Taira, Takanori Hidaka, Junko Kawashima, Eiichi N Kodama, Akira Uruno, Yohei Hamanaka, Hiroaki Tomita, Hiroaki Hashizume, Kenichi Noguchi, Fumiki Katsuoka, Seizo Koshiba, Kazuki Kumada, Takahiro Nobukuni, Kinuko Ohneda, Shunji Mugikura, Ritsuko Shimizu, Masataka Kambe, Yoshinobu Saito, Tadao Kobayashi, Yoko Izumi, Kengo Kinoshita, Nobuo Fuse, Nobuo Yaegashi, Atsushi Hozawa, Masayuki Yamamoto, Shinichi Kuriyama

    International journal of epidemiology　54　(5)　2025/08/18

    DOI： 10.1093/ije/dyaf148 　

  3. Unraveling the Trajectories from Health to Disease Onset Using Health Checkup Data. International-journal

    Satoshi Nagaie, Satoshi Mizuno, Soichi Ogishima

    Studies in health technology and informatics　329　1934-1935　2025/08/07

    DOI： 10.3233/SHTI251286 　

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    Personalized prevention based on individual health data is vital in modern healthcare. We analyzed four years of checkup data from 96,093 individuals (20-74 years) to map transitions from healthy states to mibyo (pre-disease) and disease onset. Using dimensionality reduction and clustering, we identified 43 male and 33 female health status clusters, revealing distinct transition trajectories that inform targeted preventive strategies.

  4. Development of AI Models for Early Prediction of Preterm Birth. International-journal

    Satoshi Mizuno, Satoshi Nagaie, Gen Tamiya, Shinichi Kuriyama, Taku Obara, Mami Ishikuro, Hiroshi Tanaka, Kengo Kinoshita, Junichi Sugawara, Masayuki Yamamoto, Nobuo Yaegashi, Masatoshi Saito, Soichi Ogishima

    Studies in health technology and informatics　329　1932-1933　2025/08/07

    DOI： 10.3233/SHTI251285 　

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    Preterm birth is one of the most important neonatal complications. In this study, we aimed to establish an artificial intelligence model for early prediction of preterm birth. Based on genetic and lifestyle data from over 20,000 neonates, we developed high-performed early prediction models up to 0.92 of AUC. Our developed models will help early prediction and appropriate intervention of preterm birth.

  5. Absolute quantification of eight human milk oligosaccharides in breast milk to evaluate their concentration profiles and associations with infants' neurodevelopmental outcomes. International-journal

    Keigo Sato, Yoshitaka Nakamura, Kazuhito Fujiyama, Kinuko Ohneda, Takahiro Nobukuni, Soichi Ogishima, Satoshi Mizuno, Seizo Koshiba, Shinichi Kuriyama, Shinji Jinno

    Journal of food science　89　(12)　10152-10170　2024/12

    DOI： 10.1111/1750-3841.17597 　

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    Human milk oligosaccharides (HMOs) have been positively associated with child neurodevelopment in some cohort studies. However, there is a lack of consistency in the association between HMOs and benefits to infants' brains. Moreover, the quantification methods for HMOs have not yet been standardized. In this study, we developed a quantification method for evaluating eight HMOs (2'-fucosyllactose [2'-FL], 3'-fucosyllactose [3'-FL], 3'-sialyllactose [3'-SL], 6'-sialyllactose [6'-SL], lactosialyltetrasaccharide a [LSTa], lactosialyltetrasaccharide b [LSTb], lactosialyltetrasaccharide c [LSTc], and disialyllacto-N-tetraose [DSLNT]) in breast milk. After validating the method, we applied it to 1-month breast milk samples (n = 150) from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study to assess HMO profiles in breast milk and their possible association with changes in head circumference z-score (ΔHCZ) and neurodevelopmental scores of children (as measured by the Ages and Stages Questionnaire, Third Edition). The validation demonstrated that the method had relative standard deviation ≤ 12.7% of precision and 79.5-110.9% of accuracy. Using this method, eight HMO levels (2'-FL, 0-4.74 mg/mL; 3'-FL, 0.02-1.52 mg/mL; 3'-SL, 0.07-0.32 mg/mL; 6'-SL, 0.01-0.70 mg/mL; LSTa, 0.002-0.043 mg/mL; LSTb, 0.02-0.31 mg/mL; LSTc, 0.001-0.47 mg/mL; and DSLNT, 0.09-0.71 mg/mL [min-max, all participants]) and the ratio of low secretors (16.0%) in the Japanese cohort were obtained. The obtained HMO levels in breast milk were subjected to multivariate analysis to screen for HMOs showing a positive association with ΔHCZ and neurodevelopmental scores. The results proposed that ΔHCZ was positively associated with LSTb and 2'-FL levels, whereas neurodevelopmental scores were positively associated with 2'-FL levels (among all participants) and 3'-SL and DSLNT levels (among secretor participants). This study showed that the developed method provides HMO profiles in Japanese breast milk, as well as additional information on the associations between specific HMOs and neurodevelopment, reinforcing the sum of evidence for the role of HMOs in the brain.

  6. Early prediction of hypertensive disorders of pregnancy toward preventive early intervention. International-journal

    Satoshi Mizuno, Satoshi Nagaie, Junichi Sugawara, Gen Tamiya, Taku Obara, Mami Ishikuro, Shinichi Kuriyama, Nobuo Yaegashi, Hiroshi Tanaka, Masayuki Yamamoto, Soichi Ogishima

    AJOG global reports　4　(4)　100383-100383　2024/11

    DOI： 10.1016/j.xagr.2024.100383 　

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    BACKGROUND: Various disease prediction models have been developed, capitalizing on the wide use of electronic health records, but environmental factors that are important in the development of noncommunicable diseases are rarely included in the prediction models. Hypertensive disorders of pregnancy are leading causes of maternal morbidity and mortality and are known to cause several serious complications later in life. OBJECTIVE: This study aims to develop early hypertensive disorders of pregnancy prediction models using comprehensive environmental factors based on self-report questionnaires in early pregnancy. STUDY DESIGN: We developed machine learning and artificial intelligence models for the early prediction of hypertensive disorders of pregnancy using early pregnancy data from approximately 23,000 pregnancies in the Tohoku Medical Megabank Birth and Three Generation Cohort Study. We clarified the important features for prediction based on regression coefficients or Gini coefficients of the interpretable artificial intelligence models (i.e., logistic regression, random forest and XGBoost models) among our developed models. RESULTS: The performance of the early hypertensive disorders of pregnancy prediction models reached an area under the receiver operating characteristic curve of 0.93, demonstrating that the early hypertensive disorders of pregnancy prediction models developed in this study retain sufficient performance in hypertensive disorders of pregnancy prediction. Among the early prediction models, the best performing model was based on self-reported questionnaire data in early pregnancy (mean of 20.2 gestational weeks at filling) which consist of comprehensive lifestyles. The interpretation of the models reveals that both eating habits were dominantly important for prediction. CONCLUSION: We have developed high-performance models for early hypertensive disorders of pregnancy prediction using large-scale cohort data from the Tohoku Medical Megabank project. Our study clearly revealed that the use of comprehensive lifestyles from self-report questionnaires led us to predict hypertensive disorders of pregnancy risk at the early stages of pregnancy, which will aid early intervention to reduce the risk of hypertensive disorders of pregnancy.

  7. Development of phenotyping algorithms for hypertensive disorders of pregnancy (HDP) and their application in more than 22,000 pregnant women. International-journal

    Satoshi Mizuno, Maiko Wagata, Satoshi Nagaie, Mami Ishikuro, Taku Obara, Gen Tamiya, Shinichi Kuriyama, Hiroshi Tanaka, Nobuo Yaegashi, Masayuki Yamamoto, Junichi Sugawara, Soichi Ogishima

    Scientific reports　14　(1)　6292-6292　2024/03/15

    DOI： 10.1038/s41598-024-55914-9 　

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    Recently, many phenotyping algorithms for high-throughput cohort identification have been developed. Prospective genome cohort studies are critical resources for precision medicine, but there are many hurdles in the precise cohort identification. Consequently, it is important to develop phenotyping algorithms for cohort data collection. Hypertensive disorders of pregnancy (HDP) is a leading cause of maternal morbidity and mortality. In this study, we developed, applied, and validated rule-based phenotyping algorithms of HDP. Two phenotyping algorithms, algorithms 1 and 2, were developed according to American and Japanese guidelines, and applied into 22,452 pregnant women in the Birth and Three-Generation Cohort Study of the Tohoku Medical Megabank project. To precise cohort identification, we analyzed both structured data (e.g., laboratory and physiological tests) and unstructured clinical notes. The identified subtypes of HDP were validated against reference standards. Algorithms 1 and 2 identified 7.93% and 8.08% of the subjects as having HDP, respectively, along with their HDP subtypes. Our algorithms were high performing with high positive predictive values (0.96 and 0.90 for algorithms 1 and 2, respectively). Overcoming the hurdle of precise cohort identification from large-scale cohort data collection, we achieved both developed and implemented phenotyping algorithms, and precisely identified HDP patients and their subtypes from large-scale cohort data collection.

  8. Effect of Nicotinamide Mononucleotide Concentration in Human Milk on Neurodevelopmental Outcome: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Yoshie Saito, Keigo Sato, Shinji Jinno, Yoshitaka Nakamura, Takahiro Nobukuni, Soichi Ogishima, Satoshi Mizuno, Seizo Koshiba, Shinichi Kuriyama, Kinuko Ohneda, Masashi Morifuji

    Nutrients　16　(1)　2023/12/31

    DOI： 10.3390/nu16010145 　

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    (1) Background: Breast milk is the only source of nutrition for breastfed infants, but few studies have examined the relationship between breast milk micronutrients and infant neurodevelopmental outcome in exclusively breastfed infants. The aim of this study was to characterize the association between nicotinamide adenine dinucleotide (NAD)-related compounds in the breast milk of Japanese subjects and infant neurodevelopmental outcome. (2) Methods: A total of 150 mother-child pairs were randomly selected from the three-generation cohort of the Tohoku Medical Megabank in Japan. Infants were exclusively breastfed for up to 6 months. Breast milk was collected at 1 month postpartum, and the quantity of NAD-related substances in the breast milk was quantified. The mothers also completed developmental questionnaires at 6, 12, and 24 months. The relationship between the concentration of NAD-related substances in breast milk and developmental indicators was evaluated via ordinal logistic regression analysis. (3) Results: Nicotinamide mononucleotide (NMN) was quantified as the major NAD precursor in breast milk. The median amount of NMN in the breast milk was 9.2 μM. The NMN concentration in breast milk was the only NAD-related substance in breast milk that showed a significant positive correlation with neurodevelopmental outcome in infants at 24 months. (4) Conclusions: The results suggest that NMN in human milk may be an important nutrient for early childhood development.

  9. Establishment of the early prediction models of low-birth-weight reveals influential genetic and environmental factors: a prospective cohort study. International-journal Peer-reviewed

    Satoshi Mizuno, Satoshi Nagaie, Gen Tamiya, Shinichi Kuriyama, Taku Obara, Mami Ishikuro, Hiroshi Tanaka, Kengo Kinoshita, Junichi Sugawara, Masayuki Yamamoto, Nobuo Yaegashi, Soichi Ogishima

    BMC pregnancy and childbirth　23　(1)　628-628　2023/08/31

    DOI： 10.1186/s12884-023-05919-5 　

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    BACKGROUND: Low birth weight (LBW) is a leading cause of neonatal morbidity and mortality, and increases various disease risks across life stages. Prediction models of LBW have been developed before, but have limitations including small sample sizes, absence of genetic factors and no stratification of neonate into preterm and term birth groups. In this study, we challenged the development of early prediction models of LBW based on environmental and genetic factors in preterm and term birth groups, and clarified influential variables for LBW prediction. METHODS: We selected 22,711 neonates, their 21,581 mothers and 8,593 fathers from the Tohoku Medical Megabank Project Birth and Three-Generation cohort study. To establish early prediction models of LBW for preterm birth and term birth groups, we trained AI-based models using genetic and environmental factors of lifestyles. We then clarified influential environmental and genetic factors for predicting LBW in the term and preterm groups. RESULTS: We identified 2,327 (10.22%) LBW neonates consisting of 1,077 preterm births and 1,248 term births. Our early prediction models archived the area under curve 0.96 and 0.95 for term LBW and preterm LBW models, respectively. We revealed that environmental factors regarding eating habits and genetic features related to fetal growth were influential for predicting LBW in the term LBW model. On the other hand, we identified that genomic features related to toll-like receptor regulations and infection reactions are influential genetic factors for prediction in the preterm LBW model. CONCLUSIONS: We developed precise early prediction models of LBW based on lifestyle factors in the term birth group and genetic factors in the preterm birth group. Because of its accuracy and generalisability, our prediction model could contribute to risk assessment of LBW in the early stage of pregnancy and control LBW risk in the term birth group. Our prediction model could also contribute to precise prediction of LBW based on genetic factors in the preterm birth group. We then identified parental genetic and maternal environmental factors during pregnancy influencing LBW prediction, which are major targets for understanding the LBW to address serious burdens on newborns' health throughout life.

  10. 新生児臍帯血の網羅的エピゲノム解析による妊娠初期までの喫煙経験が次世代に及ぼす影響

    美辺 詩織, 小巻 翔平, 大桃 秀樹, 高嶋 聰, 小野 加奈子, 山崎 弥生, 須藤 洋一, 田高 周, 水野 聖士, 石黒 真美, 工藤 久智, 小原 拓, 熊田 和貴, 勝岡 史城, 荻島 創一, 木下 賢吾, 菅原 準一, 栗山 進一, 清水 厚志

    DOHaD研究　11　(3)　37-37　2023/08

    Publisher: (一社)日本DOHaD学会

    ISSN： 2187-2562

    eISSN： 2187-2597

  11. Secondhand smoke exposure is associated with the risk of hypertensive disorders of pregnancy: the Japan Environment and Children's Study. International-journal Peer-reviewed

    Kosuke Tanaka, Hidekazu Nishigori, Zen Watanabe, Kaoh Tanoue, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Tetsuro Hoshiai, Masatoshi Saito, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

    Hypertension research : official journal of the Japanese Society of Hypertension　46　(4)　834-844　2023/02/03

    DOI： 10.1038/s41440-022-01144-3 　

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    Hypertensive disorders of pregnancy (HDP) are associated with poor maternal and neonatal prognoses. Although several studies have indicated an effect of secondhand smoke (SHS) exposure on HDP, such evidence is lacking in Japan. Therefore, we analyzed data from the Japan Environment and Children's Study, a large-scale epidemiological investigation, to elucidate a possible link between SHS exposure and HDP risk. Data were obtained from the all-birth fixed datasets and included information on 104,062 fetuses and their parents. SHS exposure was assessed in terms of the frequency (rarely, 1-3, or 4-7 days/week) and the daily duration of exposure (<1, 1-2, or ≥2 h(s)/day). Modified Poisson regression model analyses were performed with adjustment for known risk factors for HDP. Additionally, the population attributable fractions (PAFs) of SHS exposure and maternal smoking to HDP prevalence were estimated. The relative risks of developing HDP among individuals with SHS exposures of 4-7 days/week and ≥2 h/day were 1.18 and 1.27 (95% confidence interval: 1.02-1.36 and 0.96-1.67), respectively, compared to the reference groups (rare exposure and <1 h/day). The PAFs for the risk of HDP due to SHS exposure and perinatal smoking were 3.8% and 1.8%, respectively. Japanese women with greater exposure to SHS have a higher risk of HDP after adjustment for possible confounding factors; thus, relevant measures are required to reduce SHS exposure to alleviate HDP risk. The association between second-hand smoking exposure and hypertensive disorders of pregnancy risk was analyzed using the JECS data. The relative risks in 4-7 days/week and ≥2 h/day of SHS exposures were 1.18 and 1.27, respectively. The PAFs due to SHS exposure and maternal smoking were 3.80% and 1.81%, respectively.

  12. A knowledge representation model for family relationship to three generation Peer-reviewed

    Kazuro Shimokawa, Mami Ishikuro, Taku Obara, Hirohito Metoki, Satoshi Mizuno, Satoshi Nagaie, Masato Nagai, Chizuru Yamanaka, Hiroko Matsubara, Mayumi Kato, Yuki Sato, Soichi Ogishima, Takako Takai, Masahiro Kikuya, Atsushi Hozawa, Fuji Nagami, Shinichi Kuriyama, Takashi Suzuki, Kengo Kinoshita, Masayuki Yamamoto, Hiroshi Tanaka

    Bioinformation　18　(12)　1166-1172　2022/12/31

    Publisher: Biomedical Informatics

    DOI： 10.6026/973206300181166 　

    ISSN： 0973-8894

    eISSN： 0973-2063

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    A system for inputting and storing family information, named “BirThree Enrollment,” was developed to promote a birth and three-generation cohort study (BirThree Cohort Study). In this cohort study, it was necessary to satisfy many operational demands while constantly overwriting and changing input information. Complex kinship information must be quickly and accurately inputed and corrected, and information on those families not yet recruited must be retrieved. For these purposes, many devices are needed, from an input interface to the internal data structure. In the field of genetic statistics, a simple standard expressive form (describe father-child relation and mother-child relation) is used for describing family structure. However, this form doesn't have sufficient information. So we developed a new form in conducting the BirThree Cohort Study. Hence, we expanded the data structure, and constructed the Input control system. Family pedigree information is stored along with initial clinical information, and this enabled the input of all self-reported information to the data base. Operators are able to input this family information before the day is out. As a result, when recruitment is completed, family information will be completed concurrently. Therefore, operators can immediately know certain person's family structure. In this model data correction was improved dramatically, and the system was operated successfully. This study is the first report of the method for storing three generations of family data.

  13. dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project

    Soichi Ogishima, Satoshi Nagaie, Satoshi Mizuno, Ryosuke Ishiwata, Keita Iida, Kazuro Shimokawa, Takako Takai-Igarashi, Naoki Nakamura, Sachiko Nagase, Tomohiro Nakamura, Naho Tsuchiya, Naoki Nakaya, Keiko Murakami, Fumihiko Ueno, Tomomi Onuma, Mami Ishikuro, Taku Obara, Shunji Mugikura, Hiroaki Tomita, Akira Uruno, Tomoko Kobayashi, Akito Tsuboi, Shu Tadaka, Fumiki Katsuoka, Akira Narita, Mika Sakurai, Satoshi Makino, Gen Tamiya, Yuichi Aoki, Ritsuko Shimizu, Ikuko N. Motoike, Seizo Koshiba, Naoko Minegishi, Kazuki Kumada, Takahiro Nobukuni, Kichiya Suzuki, Inaho Danjoh, Fuji Nagami, Kozo Tanno, Hideki Ohmomo, Koichi Asahi, Atsushi Shimizu, Atsushi Hozawa, Shinichi Kuriyama, Masayuki Yamamoto, Michiaki Abe, Yayoi Aizawa, Yuichi Aoki, Koichi Chida, Inaho Danjoh, Shinichi Egawa, Ai Eto, Takamitsu Funayama, Nobuo Fuse, Yohei Hamanaka, Yuki Harada, Hiroaki Hashizume, Shinichi Higuchi, Sachiko Hirano, Takumi Hirata, Masahiro Hiratsuka, Atsushi Hozawa, Kazuhiko Igarashi, Jin Inoue, Noriko Ishida, Naoto Ishii, Tadashi Ishii, Mami Ishikuro, Kiyoshi Ito, Sadayoshi Ito, Maiko Kageyama, Fumiki Katsuoka, Hiroshi Kawame, Junko Kawashima, Masahiro Kikuya, Kengo Kinoshita, Kazuyuki Kitatani, Tomomi Kiyama, Hideyasu Kiyomoto, Tomoko Kobayashi, Eiichi Kodama, Mana Kogure, Kaname Kojima, Sachie Koreeda, Seizo Koshiba, Shihoko Koyama, Hisaaki Kudo, Kazuki Kumada, Shigeo Kure, Miho Kuriki, Shinichi Kuriyama, Yoko Kuroki, Norihide Maikusa, Satoshi Makino, Hiroko Matsubara, Hiroyuki Matsui, Hirohito Metoki, Takahiro Mimori, Naoko Minegishi, Kazuharu Misawa, Masako Miyashita, Satoshi Mizuno, Hozumi Motohashi, Ikuko N. Motoike, Satoshi Nagaie, Masato Nagai, Fuji Nagami, Masao Nagasaki, Sachiko Nagase, Naoki Nakamura, Tomohiro Nakamura, Naoki Nakaya, Keiko Nakayama, Akira Narita, Ichiko Nishijima, Takahiro Nobukuni, Kotaro Nochioka, Taku Obara, Soichi Ogishima, Noriaki Ohuchi, Gervais Olivier, Noriko Osumi, Hiroshi Otsu, Akihito Otsuki, Daisuke Saigusa, Sakae Saito, Tomo Saito, Masaki Sakaida, Mika Sakurai-Yageta, Yuki Sato, Yukuto Sato, Atsushi Sekiguchi, Chen-Yang Shen, Tomoko F. Shibata, Ritsuko Shimizu, Kazuro Shimokawa, Matsuyuki Shirota, Junichi Sugawara, Kichiya Suzuki, Yoichi Suzuki, Shu Tadaka, Makiko Taira, Takako Takai-Igarashi, Yuji Takano, Yasuyuki Taki, Gen Tamiya, Osamu Tanabe, Hiroshi Tanaka, Yukari Tanaka, Shunsuke Teraguchi, Takahiro Terakawa, Teiji Tominaga, Hiroaki Tomita, Akito Tsuboi, Naho Tsuchiya, Ichiro Tsuji, Masao Ueki, Akira Uruno, Nobuo Yaegashi, Junya Yamagishi, Yumi Yamaguchi-Kabata, Chizuru Yamanaka, Riu Yamashita, Jun Yasuda, Junji Yokozawa, Kazunori Waki, Makoto Sasaki, Junko Akai, Ryujin Endo, Akimune Fukushima, Ryohei Furukawa, Tsuyoshi Hachiya, Kouhei Hashizume, Jiro Hitomi, Yasushi Ishigaki, Shohei Komaki, Yuka Kotozaki, Takahiro Mikami, Motoyuki Nakamura, Naoyuki Nishiya, Satoshi Nishizuka, Yoko Nomura, Kuniaki Ogasawara, Hideki Ohmomo, Shinichi Omama, Ryo Otomo, Kotaro Otsuka, Kotaro Oyama, Kiyomi Sakata, Ryohei Sasaki, Mamoru Satoh, Namie Sato, Atsushi Shimizu, Yu Shiwa, Yoichi Sutoh, Nobuyuki Takanashi, Noriko Takebe, Fumitaka Tanaka, Ryoichi Tanaka, Kozo Tanno, Tomoharu Tokutomi, Kayono Yamamoto, Fumio Yamashita, Nobuo Fuse, Teiji Tominaga, Shigeo Kure, Nobuo Yaegashi, Kengo Kinoshita, Makoto Sasaki, Hiroshi Tanaka, Masayuki Yamamoto

    Human Genome Variation　8　(1)　2021/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41439-021-00175-5 　

    eISSN： 2054-345X

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    <title>Abstract</title>To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an integrated biobank, we developed an integrated database called “dbTMM” that incorporates both the individual cohort/clinical data and the genome/multiomics data of 157,191 participants in the Tohoku Medical Megabank project. To our knowledge, dbTMM is the first database to store individual whole-genome data on a variant-by-variant basis as well as cohort/clinical data for over one hundred thousand participants in a prospective cohort study. dbTMM enables us to stratify our cohort by both genome-wide genetic factors and environmental factors, and it provides a research and development platform that enables prospective analysis of large-scale data from genome cohorts.

  14. Analysis of HLA-G long-read genomic sequences in mother-offspring pairs with preeclampsia. International-journal

    Ayako Nishizawa, Kazuki Kumada, Keiko Tateno, Maiko Wagata, Sakae Saito, Fumiki Katsuoka, Satoshi Mizuno, Soichi Ogishima, Masayuki Yamamoto, Jun Yasuda, Junichi Sugawara

    Scientific reports　10　(1)　20027-20027　2020/11/18

    DOI： 10.1038/s41598-020-77081-3 　

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    Preeclampsia is a pregnancy-induced disorder that is characterized by hypertension and is a leading cause of perinatal and maternal-fetal morbidity and mortality. HLA-G is thought to play important roles in maternal-fetal immune tolerance, and the associations between HLA-G gene polymorphisms and the onset of pregnancy-related diseases have been explored extensively. Because contiguous genomic sequencing is difficult, the association between the HLA-G genotype and preeclampsia onset is controversial. In this study, genomic sequences of the HLA-G region (5.2 kb) from 31 pairs of mother-offspring genomic DNA samples (18 pairs from normal pregnancies/births and 13 from preeclampsia births) were obtained by single-molecule real-time sequencing using the PacBio RS II platform. The HLA-G alleles identified in our cohort matched seven known HLA-G alleles, but we also identified two new HLA-G alleles at the fourth-field resolution and compared them with nucleotide sequences from a public database that consisted of coding sequences that cover the 3.1-kb HLA-G gene span. Intriguingly, a potential association between preeclampsia onset and the poly T stretch within the downstream region of the HLA-G*01:01:01:01 allele was found. Our study suggests that long-read sequencing of HLA-G will provide clues for characterizing HLA-G variants that are involved in the pathophysiology of preeclampsia.

  15. 日本語版妊娠高血圧腎症オントロジーの開発

    水野 聖士, 和形 麻衣子, 永家 聖, 八重樫 伸生, 菅原 準一, 荻島 創一

    医療情報学　40　(3)　115-124　2020/11

    Publisher: (一社)日本医療情報学会

    ISSN： 0289-8055

  16. Maternal Baseline Characteristics and Perinatal Outcomes: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

    Junichi Sugawara, Mami Ishikuro, Taku Obara, Tomomi Onuma, Keiko Murakami, Masahiro Kikuya, Fumihiko Ueno, Aoi Noda, Satoshi Mizuno, Tomoko Kobayashi, Yohei Hamanaka, Kichiya Suzuki, Eiichi Kodama, Naho Tsuchiya, Akira Uruno, Yoichi Suzuki, Osamu Tanabe, Hideyasu Kiyomoto, Akito Tsuboi, Atsushi Shimizu, Seizo Koshiba, Naoko Minegishi, Soichi Ogishima, Gen Tamiya, Hirohito Metoki, Atsushi Hozawa, Nobuo Fuse, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Shinichi Kuriyama, Masayuki Yamamoto

    Journal of epidemiology　32　(2)　69-79　2020/10/10

    DOI： 10.2188/jea.JE20200338 　

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    BACKGROUND: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study was launched in 2013 to evaluate the complex interactions of genetic and environmental factors in multifactorial diseases. The present study describes the maternal baseline profile and perinatal data of participating mothers and infants. METHODS: Expectant mothers living in Miyagi prefecture were recruited from obstetric facilities or affiliated centers between 2013 and 2017. Three sets of self-administered questionnaires were collected, and the medical records were reviewed to obtain precise information about each antenatal visit and each delivery. Biospecimens, including blood, urine, umbilical cord blood, and breast milk, were collected for the study biobank. The baseline maternal sociodemographic characteristics, results of screening tests, and obstetric outcomes were analyzed according to the maternal age group. RESULTS: A total of 23 406 pregnancies involving 23 730 fetuses resulted in 23 143 live births. Younger maternal participants had a tendency toward a higher incidence of threatened abortion and threatened premature labor, while older age groups exhibited a significantly higher rate of low lying placenta, placenta previa, gestational diabetes and hypertensive disorders of pregnancy. CONCLUSIONS: The present study clearly shows the distribution of maternal baseline characteristics and the range of perinatal outcomes according to maternal age group. This cohort study can provide strategic information for creating breakthroughs in the pathophysiology of perinatal, developmental, and noncommunicable diseases by collaborative data visiting or sharing.

  17. Low birth weight and abnormal pre-pregnancy body mass index were at higher risk for hypertensive disorders of pregnancy. International-journal Peer-reviewed

    Maiko Wagata, Mami Ishikuro, Taku Obara, Masato Nagai, Satoshi Mizuno, Naoki Nakaya, Tomohiro Nakamura, Takumi Hirata, Naho Tsuchiya, Hirohito Metoki, Soichi Ogishima, Atsushi Hozawa, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama, Junichi Sugawara

    Pregnancy hypertension　22　119-125　2020/08/05

    DOI： 10.1016/j.preghy.2020.08.001 　

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    Low birth weight is known to be associated with hypertension, cardiovascular disease and hypertensive disorders of pregnancy (HDP); however, this association might vary by race/ethnicity. This study aimed to clarify the association between women's own birth weight and their subsequent risk for HDP in a Japanese population, in combination with pre-pregnancy body mass index (BMI). We conducted a cohort study as part of the Tohoku Medical Megabank Birth and Three-Generation Cohort Study in Miyagi, Japan. Our study's population included 4810 women. A multivariate logistic regression analysis was performed to calculate the adjusted odds ratio (aOR) and the 95% confidence interval (CI) of the women's own birth weight for HDP, in the combination categories of birth weight and pre-pregnancy BMI. As a result, the group with a low birth weight of <2500 g had a significant association with HDP (the aOR, 1.50; 95% CI, 1.02-2.21). In the subtype analysis, the odds ratio for only preeclampsia was significantly increased in the low birth weight group (aOR, 3.37; 95% CI, 1.84-6.16). In the group with a low birth weight, the prevalence of HDP was higher in both the underweight and overweight groups. In conclusion, there was a significant association between low birth weight and subsequent HDP in Japanese women. Furthermore, a significant association with HDP was found for women born with a low birth weight who were underweight or overweight as adults. Maintaining a normal weight may be effective for preventing HDP even if a woman was born small.

  18. Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective. International-journal

    Shinichi Kuriyama, Hirohito Metoki, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Masato Nagai, Hiroko Matsubara, Tomoko Kobayashi, Junichi Sugawara, Gen Tamiya, Atsushi Hozawa, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Takumi Hirata, Ichiro Tsuji, Fuji Nagami, Nobuo Fuse, Tomohiko Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Yoichi Suzuki, Noriko Osumi, Keiko Nakayama, Kiyoshi Ito, Shinichi Egawa, Koichi Chida, Eiichi Kodama, Hideyasu Kiyomoto, Tadashi Ishii, Akito Tsuboi, Hiroaki Tomita, Yasuyuki Taki, Hiroshi Kawame, Kichiya Suzuki, Naoto Ishii, Soichi Ogishima, Satoshi Mizuno, Takako Takai-Igarashi, Naoko Minegishi, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Osamu Tanabe, Seizo Koshiba, Hiroaki Hashizume, Hozumi Motohashi, Teiji Tominaga, Sadayoshi Ito, Kozo Tanno, Kiyomi Sakata, Atsushi Shimizu, Jiro Hitomi, Makoto Sasaki, Kengo Kinoshita, Hiroshi Tanaka, Tadao Kobayashi, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto

    International journal of epidemiology　49　(1)　18-19　2020/02/01

    DOI： 10.1093/ije/dyz169 　

  19. Update on the prevalence and determinants of folic acid use in Japan evaluated with 91,538 pregnant women: the Japan Environment and Children's Study. International-journal Peer-reviewed

    Tomofumi Ishikawa, Taku Obara, Hidekazu Nishigori, Toshie Nishigori, Hirohito Metoki, Mami Ishikuro, Nozomi Tatsuta, Satoshi Mizuno, Kasumi Sakurai, Ichiko Nishijima, Yuriko Murai, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians　33　(3)　427-436　2020/02

    DOI： 10.1080/14767058.2018.1494712 　

    ISSN： 1476-7058

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    Objective: To provide the latest and most promising evidence on the prevalence and determinants for folic acid supplementation in pregnant women in Japan, including differences in prevalence between interview years and determinants across regions.Materials and methods: The study participants were enrolled from 15 regional centers across Japan between January 2011 and March 2014. Information on the use of folic acid supplementation before and during pregnancy and the characteristics of the participants were collected using questionnaires, medical chart reviews, and interviews by research coordinators.Results: Data for 91,538 women who provided sufficient data on folic acid supplementation were analyzed. The prevalence of adequate users was 8.0%, which, although low, tended to improve over the 4-year recruitment period. Various kinds of sociodemographic factors, lifestyle habits, and obstetrical and medication use history were significant and independent determinants for folic acid use. Associations between adequate preconception folic acid use and its major determinants tended to be similar across regions.Conclusions: Although the prevalence of adequate folic acid use was low, it increased from 2011 to 2014. Reproductive-aged women who have determinants for inadequate folic acid use should be informed about the need for preconception folic acid supplementation to help prevent neural tube defects.

  20. Interannual Changes in the Prevalence of Intimate Partner Violence Against Pregnant Women in Miyagi Prefecture After the Great East Japan Earthquake: The Japan Environment and Children's Study. International-journal Peer-reviewed

    Kaou Tanoue, Hidekazu Nishigori, Zen Watanabe, Kosuke Tanaka, Kasumi Sakurai, Satoshi Mizuno, Mami Ishikuro, Taku Obara, Masahito Tachibana, Tetsuro Hoshiai, Masatoshi Saito, Junichi Sugawara, Nozomi Tatsuta, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

    Journal of interpersonal violence　Epub ahead of print　(21-22)　886260519881517-886260519881517　2019/10/16

    DOI： 10.1177/0886260519881517 　

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    This study aimed to clarify the interannual changes in intimate partner violence against pregnant women after the March 11, 2011 Great East Japan Earthquake in target areas of Miyagi Prefecture that were damaged by the earthquake and tsunami. Because of this disaster, in Miyagi Prefecture, approximately 12,000 people died or went missing, and approximately 238,000 buildings were destroyed. According to the U.S. Geological Survey, the Great East Japan Earthquake is the fourth largest earthquake in the world and the largest in Japan since 1900. The present study was part of the Japan Environment and Children's Study. Data from June 2011 to May 2014 of 79,222 pregnant women were analyzed, calculating the prevalence of physical and mental intimate partner violence in the inland, north coastal, and south coastal areas of Miyagi. These prevalence rates were compared with nationwide rates of intimate partner violence in 2011 using univariate and logistic regression analyses. After the disaster, the incidence of mental intimate partner violence increased in the south coastal area and then improved later (19.4%, 13.1%, and 13.3% for south coastal area, and 13.8%, 13.8%, and 13.1% for nationwide in 2011, 2012, and 2013, respectively). However, in the north coastal area, the incidence of physical intimate partner violence increased after the disaster and then improved later (2.7%, 1.5%, and 1.3% for north coastal area, and 1.4%, 1.3%, and 1.1% for nationwide in 2011, 2012, and 2013, respectively). In the inland area, however, the prevalence of both mental and physical intimate partner violence was consistently higher than nationwide rates after the disaster.

  21. Mother-to-infant bonding failure and intimate partner violence during pregnancy as risk factors for father-to-infant bonding failure at 1 month postpartum: an adjunct study of the Japan Environment and Children's Study. International-journal Peer-reviewed

    Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Hirohito Metoki, Satoshi Mizuno, Mami Ishikuro, Kasumi Sakurai, Hirotaka Hamada, Zen Watanabe, Tetsuro Hoshiai, Takahiro Arima, Kunihiko Nakai, Shinichi Kuriyama, Nobuo Yaegashi

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians　33　(16)　1-8　2019/04/15

    DOI： 10.1080/14767058.2018.1560414 　

    ISSN： 1476-7058

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    OBJECTIVE: To survey the frequency and risk factors for father-to-infant lack of affection (LA) and anger/rejection (AR) bonding failure at 1 month postpartum. MATERIAL AND METHODS: The study participants enrolled in the prospective birth cohort study of an adjunct study of the Japan Environment & Children's Study. Bonding failure, psychological distress during pregnancy and postnatal depression symptoms were evaluated using the Japanese version of the Mother-Infant Bonding Scale (MIBS-J), the Kessler 6-item (K6) psychological distress scale and the Edinburgh Postnatal Depression Scale (EPDS-J). This study extracted relative factors based on approximately 10% occupancy of the total high scores in MIBS-J subscales as a cut-off for bonding failure. The cut-off scores on the paternal EPDS-J were eight, on maternal EPDS-J was 9, and on the K6 psychological distress scale score was 13. RESULTS: A total of 1008 couples who had single delivery were assessed at 1 month postpartum, respectively. The prevalence of paternal MIBS-J_LA scores ≥4 was 8.3%, MIBS-J_AR scores ≥3 was 7.9%, and EPDS-J scores ≥8 was 11.2%, respectively. In the multiple logistics analysis, paternal MIBS-J_LA scores ≥4 were significantly associated with maternal MIBS-J_LA score ≥3 (adjusted odds ratio (AOR) 2.814; 95% confidence interval (CI): 1.377-5.747), mental intimate partner violence (IPV) against the mother during pregnancy (AOR 2.176; 95% CI: 1.185-3.997), maternal K6 psychological distress scale score ≥13 (AOR 2.980; 95% CI: 1.317-6.745), paternal EPDS-J score ≥8 (AOR 3.227; 95% CI: 1.767-5.892), and a history of mental health disorder (AOR 4.125; 95% CI: 1.423-11.963). Paternal MIBS-J_AR scores ≥3 were significantly associated with maternal MIBS-J_AR scores ≥3 (AOR 5.082; 95% CI: 2.453-10.529), a history of physical IPV against the mother during pregnancy (AOR 5.230; 95% CI: 1.016-26.920), paternal K6 psychological distress scale score ≥13 (AOR 4.145; 95% CI: 1.311-13.107), and paternal EPDS-J scores ≥8 (AOR 4.479; 95% CI: 2.503-8.013). In Pearson's product moment correlation coefficient analyses between paternal and maternal MIBS-J score, MIBS-J_LA score was r = 0.2112, p < .0001, and MIBS-J_AR score was r = 0.3281, p < .0001. CONCLUSION: Father-to-infant lack of affection bonding failure was associated with mother-to-infant lack of affection bonding failure, mental IPV against mother during pregnancy, maternal psychological distress during pregnancy, paternal postpartum depression symptoms, and history of paternal mental health disorders. Father-to-infant anger/rejection bonding failure was associated with mother-to-infant anger/rejection bonding failure, physical IPV against mother during pregnancy, paternal psychological distress during pregnancy, and paternal postpartum depression symptoms. Since bonding failure is a risk factor for infant maltreatment, further investigations are recommended to fully assess these associations to resolve parent perinatal mental health issues for preventing father-to-infant bonding failure.

  22. Higher prevalence of hypertensive disorders of pregnancy in women who smoke: the Japan environment and children's study. International-journal Peer-reviewed

    Kosuke Tanaka, Hidekazu Nishigori, Zen Watanabe, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Hirotaka Hamada, Tetsuro Hoshiai, Masatoshi Saito, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

    Hypertension research : official journal of the Japanese Society of Hypertension　42　(4)　558-566　2019/04

    DOI： 10.1038/s41440-019-0206-x 　

    ISSN： 0916-9636

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    Smoking during pregnancy is a risk factor for various adverse birth outcomes but lowers the risk of preeclampsia. Cardiovascular adaptations might underlie these associations. We examined the association of maternal smoking with the risk of hypertensive disorders of pregnancy (HDP) in a low-risk population-based cohort of 76,303 pregnant women. This study was a part of the Japan Environment and Children's Study. Smoking status was assessed using questionnaires completed by participants. Information about HDP was assessed using questionnaires completed by doctors. Compared with that for women who did not smoke, women who continued smoking >10 cigarettes per day during pregnancy had a significantly higher risk of developing HDP (odds ratio: 1.58, 95% confidence interval: 1.11-2.25). In multivariate analyses with adjustment for possible confounding factors, the association still remained (odds ratio: 1.51, 95% confidence interval: 1.04-2.19). When we regarded the number of cigarettes as a continuous variable, there was a linear association between the number of cigarettes and risk of HDP, with an odds ratio of 1.02 per cigarette per day (95% confidence interval: 1.00-1.04). Smoking a greater number of cigarettes was associated with a higher risk of HDP after adjustment for possible confounding factors. Cigarette smoking cessation may avoid the complications of HDP. Our findings suggest that, in addition to the risk of small-for-gestational-age children, an increased risk of HDP should be considered in the management of pregnant women who smoke cigarettes.

  23. The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children's Study. International-journal Peer-reviewed

    Hiromitsu Hattori, Akane Kitamura, Fumiaki Takahashi, Norio Kobayashi, Akiko Sato, Naoko Miyauchi, Hidekazu Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Shinichi Kuriyama, Hirohito Metoki, Nobuo Yaegashi, Kunihiko Nakai, Takahiro Arima

    Reproductive biology and endocrinology : RB&E　17　(1)　27-27　2019/02/22

    DOI： 10.1186/s12958-019-0471-1 　

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    BACKGROUND: Some studies have suggested that blastocyst transfer is associated with i) imbalance in the secondary sex ratio (SSR) (which favors male offspring), ii) increased incidence of monozygotic twins (MZT). In contrast, others have not found these changes. In this study, we evaluated the association between blastocyst transfer and SSR and MZT, considering potential parental confounders. METHODS: The Japan Environment and Children's Study is a large, nationwide longitudinal birth cohort study funded by the Ministry of the Environment of Japan. We used this large dataset, including 103,099 pregnancies, to further investigate the association between blastocyst transfer, SSR and MZT, using spontaneously conceived pregnancies, non-assisted reproductive technology (non-ART) treatment (intrauterine insemination and ovulation induction with timed intercourse) and cleavage stage embryo transfer for comparison. We evaluated the association with each group, the SSR, and the frequency of MZT, calculating the adjusted odds ratio (AOR) using multivariable logistic regression analyses, adjusting for potential parental confounders such as basic health and socioeconomic status. RESULTS: For each group (spontaneous conception vs. non-ART treatment vs. cleavage stage embryo transfer vs. blastocyst transfer), the percentages of males were 51.3% vs 50.7% vs 48.9% vs 53.4% and the monozygotic twinning rates per pregnancy were 0.27% vs 0.11% vs 0.27% vs 0.99% respectively. Multivariate logistic regression analyses indicated that blastocyst transfer was significantly associated with a higher SSR and higher incidence of MZT than the other three groups (SSR: AOR 1.095, 95% CI1.001-1.198; MZT: AOR 4.229, 95% CI 2.614-6.684). CONCLUSIONS: There are significant relationships between blastocyst transfer and SSR imbalance and a higher occurrence of MZT.

  24. Preconception dysmenorrhea as a risk factor for psychological distress in pregnancy: The Japan Environment and Children's Study. International-journal Peer-reviewed

    Zen Watanabe, Hidekazu Nishigori, Kaou Tanoue, Kosuke Tanaka, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Toshie Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Masatoshi Saito, Masahito Tachibana, Ikuma Fujiwara, Takahiro Arima, Takashi Takeda, Shinichi Kuriyama, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

    Journal of affective disorders　245　475-483　2019/02/15

    DOI： 10.1016/j.jad.2018.11.061 　

    ISSN： 0165-0327

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    BACKGROUND: Dysmenorrhea influences emotional distress as well as physical suffering in young non-pregnant women. The aim of this study was to assess the potential association between preconception dysmenorrhea and the development of psychological distress during pregnancy. METHODS: This study was a part of the Japan Environment and Children's Study (JECS), a nationwide birth cohort study conducted between 2011 and 2014 in Japan. A total of 87,102 pregnant Japanese women with no psychological distress (Kessler 6-item psychological distress scale [K6] score ≤ 12) in early pregnancy were eligible. Among these, 7626 had mild and 1638 had severe preconception dysmenorrhea. The prevalence and risk of maternal psychological distress (K6 scores ≥ 13) in the second or third trimester were compared among preconception dysmenorrhea severity groups. RESULTS: A higher percentage of women with mild (2.6%) or severe preconception dysmenorrhea (3.6%) suffered psychological distress during pregnancy compared to that in women without dysmenorrhea (2.1%). A multilevel logistic regression model, adjusting for baseline characteristics and the K6 score at enrollment, showed that the severity of dysmenorrhea was associated with psychological distress (mild dysmenorrhea: adjusted odds ratio [aOR], 1.154; 95% confidence interval [95% CI], 0.980-1.359; and severe dysmenorrhea: aOR, 1.457; 95% CI, 1.087-1.951). LIMITATIONS: Information about dysmenorrhea was obtained during early pregnancy. The JECS did not have clear diagnostic criteria for dysmenorrhea. CONCLUSIONS: Preconception dysmenorrhea is associated with an elevated incidence of psychological distress during pregnancy. Additionally, expectant mothers with a history of severe dysmenorrhea symptoms before pregnancy have a higher risk of developing psychological distress.

  25. The prevalence and risk factors for postpartum depression symptoms of fathers at one and 6 months postpartum: an adjunct study of the Japan Environment & Children's Study. International-journal Peer-reviewed

    Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Hirohito Metoki, Satoshi Mizuno, Mami Ishikuro, Kasumi Sakurai, Hirotaka Hamada, Zen Watanabe, Tetsuro Hoshiai, Takahiro Arima, Kunihiko Nakai, Shinichi Kuriyama, Nobuo Yaegashi

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians　33　(16)　1-8　2019/01/04

    DOI： 10.1080/14767058.2018.1560415 　

    ISSN： 1476-7058

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    OBJECTIVE: To survey prevalence and risk factors for paternal postpartum depression symptoms at one and 6 months postpartum in Japan. MATERIAL AND METHODS: The study participants enrolled in the prospective birth cohort study of an adjunct study of the Japan Environment and Children's Study. Postpartum depression symptoms were evaluated using the Japanese version of the Edinburgh Postnatal Depression Scale (EPDS-J). The cut-off scores on the paternal EPDS-J were eight and on maternal EPDS-J was nine, respectively. The multivariate logistic regression included an adjustment for paternal age, maternal age, the number of children in the family, family structure, paternal employment, paternal academic history, household income, paternal smoking status, paternal history of mental health disorders, the Kessler 6-item psychological distress scale (K6) score during pregnancy, infertility treatment, paternal mental intimate partner violence (IPV) during pregnancy, paternal physical IPV during pregnancy, the sex of the newborn, congenital anomalies of the newborn, infant disease under medical treatment, returning to the maternal parent's house to give birth or take care of infant, the father's history of disease or injury that required medical treatment, paternity leave, and the EPDS-J for mothers. RESULTS: A total of 1023 and 1330 fathers and their spouse who had a single delivery were assessed at one and 6 months postpartum, respectively. The prevalence of paternal EPDS-J scores ≥8 was 11.2 and 12.0% at one and 6 months postpartum, respectively. In the multiple logistics analysis, paternal EPDS-J scores ≥8 at 1 month postpartum was significantly associated with history of mental health disorders (adjusted odds ratio (AOR) 2.825; 95% confidence interval (CI): 1.047-7.623), K6 score ≥13 during pregnancy (AOR 4.116; 95% CI: 1.598-10.599), household income <4000 × 103 yen (AOR 1.799; 95% CI: 1.072-3.021), and infant disease under medical treatment (AOR 1.720; 95% CI: 1.015-2.915). Paternal EPDS-J scores ≥8 at 6 months postpartum was significantly associated with K6 scores ≥13 during pregnancy (AOR 4.621; 95% CI: 2.113-10.107), unemployment (AOR 3.751; 95% CI: 1.739-8.091) and maternal EPDS-J scores ≥9 (AOR 2.460; 95% CI: 1.514-3.996). CONCLUSION: The prevalence of paternal postpartum depression symptoms were 11.2 and 12.0% at one and 6 months postpartum. Paternal postpartum depression symptoms at 1 month postpartum were associated with the history of mental health disorders, psychological distress during pregnancy, low income, and infant disease under medical treatment. Paternal postpartum depression symptoms at 6 months postpartum were associated with psychological distress during pregnancy, unemployment, and maternal postpartum depression. It is important to consider the paternal postpartum depression symptoms, and further enlightenment regarding these issues is recommended in Japan.

  26. Management of family relationship information for a three-generation cohort study

    Shimokawa K, Ishikuro M, Obara T, Metoki H, Mizuno S, Nagaie S, Nagai M, Yamanaka C, Matsubara H, Kato M, Sato Y, Ogishima S, Takai-Igarashi T, Kikuya M, Hozawa A, Nagami F, Kuriyama S, Kinoshita K, Yamamoto M, Tanaka H

    bioRxiv　2019/01

  27. Blood pressure changes during twin pregnancies: the Japan Environment and Children's Study. International-journal Peer-reviewed

    Noriyuki Iwama, Hirohito Metoki, Hidekazu Nishigori, Satoshi Mizuno, Fumiaki Takahashi, Kosuke Tanaka, Zen Watanabe, Masatoshi Saito, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Takashi Sugiyama, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi

    Journal of hypertension　37　(1)　206-215　2019/01

    DOI： 10.1097/HJH.0000000000001846 　

    ISSN： 0263-6352

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    OBJECTIVES: Although a twin pregnancy is a risk factor for hypertensive disorders of pregnancy, studies investigating longitudinal blood pressure changes during twin pregnancies are uncommon. The aims of this study were to evaluate the longitudinal blood pressure changes during twin pregnancies and to compare blood pressure levels between twin and singleton pregnancies. METHODS: Five hundred dichorionic diamniotic twin, 240 monochorionic diamniotic twin, and 80 775 singleton pregnancies were included in this Japanese prospective birth cohort study. A marginal model was applied to evaluate the SBP, DBP, and mean arterial pressure levels during early gestation, mid-gestation, and late gestation. RESULTS: The blood pressure levels fell from early-to-mid-gestation and rose after mid-gestation in the dichorionic and monochorionic diamniotic twin pregnancies. The SBP and mean arterial pressure levels during early gestation and the DBP and mean arterial pressure levels during late gestation were higher in the dichorionic diamniotic twin pregnancies than those in the singleton pregnancies. The blood pressure levels in the monochorionic diamniotic twin pregnancies were higher than those in the singleton pregnancies at each gestational stage, except for the SBP during late gestation. CONCLUSION: Although the longitudinal blood pressure changes during twin pregnancies were similar to those during singleton pregnancies, the blood pressure levels during twin pregnancies were higher. Further studies that examine the associations between the longitudinal blood pressure changes during pregnancy and the perinatal outcomes in twin pregnancies are necessary.

  28. Association between alcohol consumption during pregnancy and hypertensive disorders of pregnancy in Japan: the Japan Environment and Children's Study. International-journal Peer-reviewed

    Noriyuki Iwama, Hirohito Metoki, Hidekazu Nishigori, Satoshi Mizuno, Fumiaki Takahashi, Kosuke Tanaka, Zen Watanabe, Masatoshi Saito, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Takashi Sugiyama, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi

    Hypertension research : official journal of the Japanese Society of Hypertension　42　(1)　85-94　2019/01

    DOI： 10.1038/s41440-018-0124-3 　

    ISSN： 0916-9636

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    This study examined the association between maternal alcohol consumption during pregnancy and hypertensive disorders of pregnancy in the Japan Environment and Children's Study, a nationwide birth cohort study. A total of 76 940 pregnant women were included in the analysis. Information about alcohol consumption during pregnancy was obtained using two questionnaires: T1 and T2. The mean (standard deviation) gestational age in the T1 and T2 questionnaires were 16.5 (5.8) and 27.9 (3.7) weeks, respectively. Alcohol consumption was considered as an exposure, hypertensive disorders of pregnancy as an outcome, and possible confounding factors were included in a generalized linear mixed-effects model with a logit link function. Among the study subjects, 2 348 (3.1%) women developed hypertensive disorders of pregnancy. Compared with 25 300 women who never drank alcohol, 43 women who drank alcohol according to the T1 questionnaire and continued to drink ≥150 g ethanol/week according to the T2 questionnaire had significantly higher odds of hypertensive disorders of pregnancy. The adjusted odds ratio was 3.98 (95% confidence interval [CI], 1.33-11.9). In conclusion, alcohol consumption of ≥150 g ethanol/week during pregnancy is better avoided because of the high odds of developing hypertensive disorders of pregnancy. It may be meaningful that healthcare providers confirm information about alcohol consumption during pregnancy. Moreover, discontinuation of alcohol consumption is recommended to prevent the onset of hypertensive disorders of pregnancy in Japan.

  29. Potential identification of vitamin B6 responsiveness in autism spectrum disorder utilizing phenotype variables and machine learning methods. International-journal Peer-reviewed

    Taku Obara, Mami Ishikuro, Gen Tamiya, Masao Ueki, Chizuru Yamanaka, Satoshi Mizuno, Masahiro Kikuya, Hirohito Metoki, Hiroko Matsubara, Masato Nagai, Tomoko Kobayashi, Machiko Kamiyama, Mikako Watanabe, Kazuhiko Kakuta, Minami Ouchi, Aki Kurihara, Naru Fukuchi, Akihiro Yasuhara, Masumi Inagaki, Makiko Kaga, Shigeo Kure, Shinichi Kuriyama

    Scientific reports　8　(1)　14840-14840　2018/10/04

    DOI： 10.1038/s41598-018-33110-w 　

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    We investigated whether machine learning methods could potentially identify a subgroup of persons with autism spectrum disorder (ASD) who show vitamin B6 responsiveness by selected phenotype variables. We analyzed the existing data from our intervention study with 17 persons. First, we focused on signs and biomarkers that have been identified as candidates for vitamin B6 responsiveness indicators. Second, we conducted hypothesis testing among these selected variables and their combinations. Finally, we further investigated the results by conducting cluster analyses with two different algorithms, affinity propagation and k-medoids. Statistically significant variables for vitamin B6 responsiveness, including combination of hypersensitivity to sound and clumsiness, and plasma glutamine level, were included. As an a priori variable, the Pervasive Developmental Disorders Autism Society Japan Rating Scale (PARS) scores was also included. The affinity propagation analysis showed good classification of three potential vitamin B6-responsive persons with ASD. The k-medoids analysis also showed good classification. To our knowledge, this is the first study to attempt to identify subgroup of persons with ASD who show specific treatment responsiveness using selected phenotype variables. We applied machine learning methods to further investigate these variables' ability to identify this subgroup of ASD, even when only a small sample size was available.

  30. 260. The Great East Japan Earthquake and hypertensive disorders of pregnancy: The TMM BirThree Cohort Study

    Taku Obara, Takuma Usuzaki, Chizuru Yamanaka, Satoshi Mizuno, Masato Nagai, Hiroko Matsubara, Masahiro Kikuya, Hirohito Metoki, Shinichi Kuriyama

    Pregnancy Hypertension　13　S112-S113　2018/10/01

    Publisher: Elsevier BV

    DOI： 10.1016/j.preghy.2018.08.332 　

    ISSN： 2210-7789

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    Introduction We experienced a devastating disaster, the Great East Japan Earthquake, in 2011. Some previous studies showed that disasters affected maternal blood pressure and their health. Its longer effect on pregnant women is necessary to investigate. Objective The purpose of this present study was to investigate if maternal disaster exposure affected their blood pressure. Methods The relationship between disaster exposure and maternal outcomes was retrospectively analyzed using the data of 4426 women who were recruited to the Tohoku Medical Megabank Birth and Three-generation Cohort Study, which was conducted in the years 2013–2017. Women were classified into three groups by the severity of the destruction of their house: group A, no destruction/did not live in the disaster-hit area; group B, half/a part of the house was destroyed; and group C, house totally/mostly destroyed. Multiple logistic regression analysis was performed to investigate the relationship between disaster exposure and hypertensive disorders of pregnancy, adjusting for body mass index, age, smoking, drinking, income, parity, and multiple pregnancy. Results Of 4,426 women eligible for the analyses, the houses of 489 women (11.0%) were totally or mostly destroyed, and the houses of 1706 women (38.5%) were half or partly destroyed. Those whose houses were not destroyed or did not live in the area affected by the disaster included 2,231 women (50.4%). The prevalence of hypertensive disorders of pregnancy in groups B and C were 0.82 and 1.47 times higher than in group A, but there was no statistical significance. Discussion Involvement in a disaster event about three to six years before pregnancy was not related to a higher prevalence of hypertensive disorders of pregnancy.

  31. Strategic Methods for Recruiting Grandparents: The Tohoku Medical Megabank Birth and Three-Generation Cohort Study. Peer-reviewed

    Mami Ishikuro, Taku Obara, Tamae Osanai, Chizuru Yamanaka, Yuki Sato, Satoshi Mizuno, Masako Miyashita, Masahiro Kikuya, Kasumi Sakurai, Atsushi Hozawa, Hiroaki Tomita, Yasuyuki Taki, Fuji Nagami, Hirohito Metoki, Shinichi Kuriyama

    The Tohoku journal of experimental medicine　246　(2)　97-105　2018/10

    DOI： 10.1620/tjem.246.97 　

    ISSN： 0040-8727

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    Involvement of family members, especially grandparents, in genome epidemiological research is important to investigate both genetic and environmental factors of common diseases. The aim of the present study was to establish strategies to obtain enough number of family recruitment, especially focusing on grandparents, for the Tohoku Medical Megabank Birth and Three-Generation Cohort Study. Our main strategies are summarized below. 1) We standardized informed consent process with reference materials to help people understand the consent form, 2) we created an invitation letter to contact family members, and 3) we recruited family members in several settings. To obtain informed consent, we were careful of explaining clearly the complex reasons as well as drawing people's attention. By the end of March 2017, the number of invitation letters distributed to family members through the pregnant women was 23,806, including 18,702 grandparents. Among the grandparents who received invitation letters, 2,935 (15.7%) responded to us. Furthermore, some grandparents were asked to provide informed consent with other family members by staff at maternal clinics or Community Support Centers, and others directly booked Community Support Centers without responding to the invitation letter. Grandparents joined the study anytime during mother's maternal check-ups or delivery. Overall, 8,054 grandparents participated in our birth cohort study. The setting in which most grandparents were recruited was our own facilities. Importantly, both paternal and maternal grandparents more frequently participated in the study if the father also participated. In conclusion, we are able to recruit not only pregnant women but also fathers and grandparents.

  32. Relationships among personality traits, metabolic syndrome, and metabolic syndrome scores: The Kakegawa cohort study. International-journal Peer-reviewed

    Hisashi Ohseto, Mami Ishikuro, Masahiro Kikuya, Taku Obara, Yuko Igarashi, Satomi Takahashi, Daisuke Kikuchi, Michiko Shigihara, Chizuru Yamanaka, Masako Miyashita, Satoshi Mizuno, Masato Nagai, Hiroko Matsubara, Yuki Sato, Hirohito Metoki, Hirofumi Tachibana, Mari Maeda-Yamamoto, Shinichi Kuriyama

    Journal of psychosomatic research　107　20-25　2018/04

    DOI： 10.1016/j.jpsychores.2018.01.013 　

    ISSN： 0022-3999

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    OBJECTIVE: Metabolic syndrome and the presence of metabolic syndrome components are risk factors for cardiovascular disease (CVD). However, the association between personality traits and metabolic syndrome remains controversial, and few studies have been conducted in East Asian populations. METHODS: We measured personality traits using the Japanese version of the Eysenck Personality Questionnaire (Revised Short Form) and five metabolic syndrome components-elevated waist circumference, elevated triglycerides, reduced high-density lipoprotein cholesterol, elevated blood pressure, and elevated fasting glucose-in 1322 participants aged 51.1±12.7years old from Kakegawa city, Japan. Metabolic syndrome score (MS score) was defined as the number of metabolic syndrome components present, and metabolic syndrome as having the MS score of 3 or higher. We performed multiple logistic regression analyses to examine the relationship between personality traits and metabolic syndrome components and multiple regression analyses to examine the relationship between personality traits and MS scores adjusted for age, sex, education, income, smoking status, alcohol use, and family history of CVD and diabetes mellitus. We also examine the relationship between personality traits and metabolic syndrome presence by multiple logistic regression analyses. RESULTS: "Extraversion" scores were higher in those with metabolic syndrome components (elevated waist circumference: P=0.001; elevated triglycerides: P=0.01; elevated blood pressure: P=0.004; elevated fasting glucose: P=0.002). "Extraversion" was associated with the MS score (coefficient=0.12, P=0.0003). No personality trait was significantly associated with the presence of metabolic syndrome. CONCLUSIONS: Higher "extraversion" scores were related to higher MS scores, but no personality trait was significantly associated with the presence of metabolic syndrome.

  33. Development of a Questionnaire Method of Screening for Citrin Deficiency in Schoolchildren Peer-reviewed

    Miyashita M, Ishikuro M, Kikuya M, Yamanaka C, Mizuno S, Nagai M, Sato Y, Obara T, Metoki H, Kikuchi A, Nakaya N, Hozawa A, Tsuji I, Yaegashi N, Yamamoto M, Kure S, Kuriyama S

    Journal of Pediatrics and Congenital Disorders　4　101　2017/07

  34. Pregnant Women's Awareness of Social Capital in the Great East Japan Earthquake-Affected Areas of Miyagi Prefecture: The Japan Environment and Children's Study Peer-reviewed

    Hidekazu Nishigori, Toshie Nishigori, Kasumi Sakurai, Satoshi Mizuno, Taku Obara, Hirohito Metoki, Zen Watanabe, Noriyuki Iwama, Mami Ishikuro, Nozomi Tatsuta, Ichiko Nishijima, Junichi Sugawara, Shinichi Kuriyama, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Fumiaki Takahashi, Nobuo Yaegashi

    DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS　11　(3)　355-364　2017/06

    DOI： 10.1017/dmp.2016.150 　

    ISSN： 1935-7893

    eISSN： 1938-744X

  35. Selective serotonin reuptake inhibitors and risk of major congenital anomalies for pregnancies in Japan: A nationwide birth cohort study of the Japan Environment and Children's Study Peer-reviewed

    Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Satoshi Mizuno, Hirohito Metoki, Tetsuro Hoshiai, Zen Watanabe, Kasumi Sakurai, Mami Ishikuro, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi

    CONGENITAL ANOMALIES　57　(3)　72-78　2017/05

    DOI： 10.1111/cga.12202 　

    ISSN： 0914-3505

    eISSN： 1741-4520

  36. Drug Use before and during Pregnancy in Japan: The Japan Environment and Children's Study. International-journal Peer-reviewed

    Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Hirohito Metoki, Mami Ishikuro, Satoshi Mizuno, Kasumi Sakurai, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Nariyasu Mano, Shinichi Kuriyama, Nobuo Yaegashi

    Pharmacy (Basel, Switzerland)　5　(2)　2017/04/10

    DOI： 10.3390/pharmacy5020021 　

    More details Close

    Purpose: To elucidate drug use before and during pregnancy in Japan. Methods: The Japan Environment and Children's Study (JECS) is an ongoing nationwide birth cohort study. We analyzed data from JECS involving cases where drugs were used for 12 months before pregnancy was diagnosed, between the time of diagnosis of pregnancy until week 12 of pregnancy, and after week 12 of pregnancy. Results: We analyzed data from 97,464 pregnant women. The percentages of pregnant women who had taken one or more drugs and supplements before diagnosis of pregnancy, between the time of diagnosis of pregnancy until week 12 of pregnancy, and after week 12 of pregnancy, were 78.4%, 57.1%, and 68.8% respectively. Excluding iron supplements, folic acid, and other vitamins and minerals, the percentages of women taking supplements were 75.3%, 36.0%, and 51.7% at each respective time point. The following drugs and supplements were frequently used for 12 months before pregnancy diagnosis: Commercially available antipyretics, analgesics, and/or medicine for treating common cold (34.7%), antipyretics, analgesics, and/or medicine for treating common colds, which were prescribed in hospitals (29.8%), antimicrobial drugs (14.0%), and anti-allergy drugs (12.5%). The following drugs and supplements were frequently used from the time of pregnancy diagnosis until week 12 of pregnancy, and after week 12 of pregnancy: folic acid (28.9% and 26.2%), antipyretics, analgesics and/or medicines for treating common cold, that were prescribed in hospitals (7.8% and 13.3%), Chinese herbal medicines (6.0% and 9.4%, and uterine relaxants (5.1% and 15.2%). Conclusions: The analysis of a nationwide cohort study showed that a high percentage of Japanese pregnant women were taking medicinal drugs. Further research is required to elucidate the relationship between drug use during pregnancy and birth defects in Japan.

  37. Incidence of Domestic Violence Against Pregnant Females After the Great East Japan Earthquake in Miyagi Prefecture: The Japan Environment and Children's Study Peer-reviewed

    Kasumi Sakurai, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Taku Obara, Noriyuki Iwama, Zen Watanabe, Mami Ishikuro, Nozomi Tatsuta, Ichiko Nishijima, Junichi Sugawara, Ikuma Fujiwara, Takahiro Arima, Shinichi Kuriyama, Hirohito Metoki, Fumiaki Takahashi, Kunihiko Nakai, Nobuo Yaegashi

    DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS　11　(2)　216-226　2017/04

    DOI： 10.1017/dmp.2016.109 　

    ISSN： 1935-7893

    eISSN： 1938-744X

  38. Prevalence and determinants of inadequate use of folic acid supplementation in Japanese pregnant women: the Japan Environment and Children's Study (JECS) Peer-reviewed

    Taku Obara, Hidekazu Nishigori, Toshie Nishigori, Hirohito Metoki, Mami Ishikuro, Nozomi Tatsuta, Satoshi Mizuno, Kasumi Sakurai, Ichiko Nishijima, Yuriko Murai, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Nariyasu Mano, Nobuo Yaegashi, Shinichi Kuriyama

    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE　30　(5)　588-593　2017/03

    DOI： 10.1080/14767058.2016.1179273 　

    ISSN： 1476-7058

    eISSN： 1476-4954

  39. Determinants of polyunsaturated fatty acid concentrations in erythrocytes of pregnant Japanese women from a birth cohort study: study protocol and baseline findings of an adjunct study of the Japan environment & Children's study Peer-reviewed

    Shoji Saito, Terue Kawabata, Nozomi Tatsuta, Fumiko Kimura, Teruo Miyazawa, Satoshi Mizuno, Hidekazu Nishigori, Takahiro Arima, Yasuo Kagawa, Kouichi Yoshimasu, Kanami Tsuno, Yuki Ito, Michihiro Kamijima, Kunihiko Nakai, Nobuo Yaegashi

    ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE　22　(1)　22　2017

    DOI： 10.1186/s12199-017-0636-5 　

    ISSN： 1342-078X

    eISSN： 1347-4715

  40. Fermented Food Consumption and Psychological Distress in Pregnant Women: A Nationwide Birth Cohort Study of the Japan Environment and Children's Study Peer-reviewed

    Fumiaki Takahashi, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Taku Obara, Hirohito Metoki, Kasumi Sakurai, Mami Ishikuro, Noriyuki Iwama, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Takashi Sugiyama, Shinichi Kuriyama, Nobuo Yaegashi

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　240　(4)　309-321　2016/12

    DOI： 10.1620/tjem.240.309 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  41. Association between social capital and the prevalence of gestational diabetes mellitus: An interim report of the Japan Environment and Children's Study Peer-reviewed

    Satoshi Mizuno, Hidekazu Nishigori, Takashi Sugiyama, Fumiaki Takahashi, Noriyuki Iwama, Zen Watanabe, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Takahiro Arima, Shinichi Kuriyama, Hirohito Metoki, Kunihiko Nakai, Hidekuni Inadera, Nobuo Yaegashi

    DIABETES RESEARCH AND CLINICAL PRACTICE　120　132-141　2016/10

    DOI： 10.1016/j.diabres.2016.07.020 　

    ISSN： 0168-8227

    eISSN： 1872-8227

  42. The Pre-Eclampsia Ontology: A Disease Ontology Representing the Domain Knowledge Specific to Pre-Eclampsia Peer-reviewed

    Satoshi Mizuno, Soichi Ogishima, Hidekazu Nishigori, Daniel G. Jamieson, Karin Verspoor, Hiroshi Tanaka, Nobuo Yaegashi, Jun Nakaya

    PLoS One　11　(10)　e0162828　2016/10

    DOI： 10.1371/journal.pone.0162828 　

    ISSN： 1932-6203

  43. Pregnant Women Had the Risk of Psychological Distress in Miyagi After the Great East Japan Earthquake: The Japan Environment and Children's Study (JECS). Peer-reviewed

    Zen Watanabe, Hirohito Metoki, Noriyuki Iwama, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Kunihiko Nakai, Takahiro Arima, Takashi Takeda, Junichi Sugawara, Shinichi Kuriyama, Nobuo Yaegashi

    REPRODUCTIVE SCIENCES　23　186A-186A　2016/03

    ISSN： 1933-7191

    eISSN： 1933-7205

  44. Network Analysis of a Comprehensive Knowledge Repository Reveals a Dual Role for Ceramide in Alzheimer's Disease Peer-reviewed

    Satoshi Mizuno, Soichi Ogishima, Kazuyuki Kitatani, Masataka Kikuchi, Hiroshi Tanaka, Nobuo Yaegashi, Jun Nakaya

    PLOS ONE　11　(2)　e0148431　2016/02

    DOI： 10.1371/journal.pone.0148431 　

    ISSN： 1932-6203

  45. Psychological distress during pregnancy in Miyagi after the Great East Japan Earthquake: The Japan Environment and Children's Study Peer-reviewed

    Zen Watanabe, Noriyuki Iwama, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Kunihiko Nakai, Takahiro Arima, Takashi Takeda, Junichi Sugawara, Shinichi Kuriyama, Hirohito Metoki, Nobuo Yaegashi

    JOURNAL OF AFFECTIVE DISORDERS　190　341-348　2016/01

    DOI： 10.1016/j.jad.2015.10.024 　

    ISSN： 0165-0327

    eISSN： 1573-2517

  46. Alzpathway, an updated map of curated signaling pathways: Towards deciphering Alzheimer's disease pathogenesis Peer-reviewed

    Soichi Ogishima, Satoshi Mizuno, Masataka Kikuchi, Akinori Miyashita, Ryozo Kuwano, Hiroshi Tanaka, Jun Nakaya

    Systems Biology of Alzheimer's Disease　1303　423-432　2015/08/02

    Publisher: Springer New York

    DOI： 10.1007/978-1-4939-2627-5_25 　

    ISSN： 1064-3745

  47. Network-based analysis for uncovering mechanisms underlying Alzheimer's disease Peer-reviewed

    Masataka Kikuchi, Soichi Ogishima, Satoshi Mizuno, Akinori Miyashita, Ryozo Kuwano, Jun Nakaya, Hiroshi Tanaka

    Systems Biology of Alzheimer's Disease　1303　479-491　2015/08/02

    Publisher: Springer New York

    DOI： 10.1007/978-1-4939-2627-5_29 　

    ISSN： 1064-3745

  48. Heterogeneity of the Fatty Acid Composition of Japanese Placentae for Determining the Perinatal Fatty Acid Status: a Methodological Study Peer-reviewed

    Isao Yamazaki, Fumiko Kimura, Kiyotaka Nakagawa, Kunihiko Nakai, Takahiro Arima, Terue Kawabata, Yasuo Kagawa, Shoji Saitoh, Satoshi Mizuno, Nobuo Yaegashi, Teruo Miyazawa

    JOURNAL OF OLEO SCIENCE　64　(8)　905-914　2015/08

    DOI： 10.5650/jos.ess15071 　

    ISSN： 1345-8957

    eISSN： 1347-3352

  49. Application of Intrinsic Subtype Classification To Microarray Data From a Set of Women With Mild and Severe Pre-Eclampsia. Peer-reviewed

    Satoshi Mizuno, Hidekazu Nishigori, Takashi Sugiyama, Soichi Ogishima, Jun Nakaya, Nobuo Yaegashi

    REPRODUCTIVE SCIENCES　22　385A-385A　2015/03

    ISSN： 1933-7191

    eISSN： 1933-7205

  50. A Map of Alzheimer's Disease-Signaling Pathways: A Hope for Drug Target Discovery Peer-reviewed

    S. Ogishima, S. Mizuno, M. Kikuchi, A. Miyashita, R. Kuwano, H. Tanaka, J. Nakaya

    CLINICAL PHARMACOLOGY & THERAPEUTICS　93　(5)　399-401　2013/05

    DOI： 10.1038/clpt.2013.37 　

    ISSN： 0009-9236

  51. AlzPathway: a comprehensive map of signaling pathways of Alzheimer's disease Peer-reviewed

    Satoshi Mizuno, Risa Iijima, Soichi Ogishima, Masataka Kikuchi, Yukiko Matsuoka, Samik Ghosh, Tadashi Miyamoto, Akinori Miyashita, Ryozo Kuwano, Hiroshi Tanaka

    BMC SYSTEMS BIOLOGY　6　(52)　2012/05

    DOI： 10.1186/1752-0509-6-52 　

    ISSN： 1752-0509

  52. Association between alcohol consumption during pregnancy and hypertensive disorders of pregnancy in Japan: the Japan Environment and Children's Study Peer-reviewed

    Iwama N, Metoki H, Nishigori H, Mizuno S, Takahashi F, Tanaka K, Watanabe Z, Saito M, Sakurai K, Ishikuro M, Obara T, Tatsuta N, Nishijima I, Sugiyama T, Fujiwara I, Kuriyama S, Arima T, Nakai K, Yaegashi N

    Hypertens Res　2008/11

Show all ︎Show first 5

Misc. 26

  1. 出生三世代コホートにおける7人家族のエピゲノム研究基盤構築

    美辺 詩織, 小巻 翔平, 大桃 秀樹, 高嶋 聰, 小野 加奈子, 山崎 弥生, 須藤 洋一, 田高 周, 水野 聖士, 石黒 真美, 工藤 久智, 小原 拓, 熊田 和貴, 勝岡 史城, 荻島 創一, 木下 賢吾, 菅原 準一, 栗山 進一, 清水 厚志

    日本抗加齢医学会総会プログラム・抄録集　23回　252-252　2023/06

    Publisher: (一社)日本抗加齢医学会

  2. The early prediction models of low-birth-weight reveals different influential environmental and genetic factors for prediction between term and preterm birth group

    水野聖士

    CBI学会大会(CD-ROM)　2023　2023

  3. 新生児臍帯血の網羅的エピゲノム解析による妊娠初期までの喫煙経験が次世代に及ぼす影響

    美辺詩織, 小巻翔平, 大桃秀樹, 高嶋聰, 小野加奈子, 山崎弥生, 須藤洋一, 田高周, 水野聖士, 石黒真美, 工藤久智, 小原拓, 熊田和貴, 勝岡史城, 荻島創一, 木下賢吾, 菅原準一, 栗山進一, 清水厚志, 清水厚志

    DOHad研究(Web)　11　(3)　2023

    ISSN： 2187-2597

  4. 行動変容を目指した疾患予測モデルの構築

    水野聖士

    CBI学会大会(CD-ROM)　2022　2022

  5. がん・生殖医療連携ネットワークの全国展開と小児・AYA世代がん患者に対する妊孕性温存の診療体制の均てん化にむけた臨床研究-がん医療の充実を志向して 本邦におけるがんサバイバーの周産期予後等の実態調査とプレコンセプションケア確立に向けた研究

    杉山隆, 太田邦明, 安岡稔晃, 岩間憲之, 荻島創一, 水野聖士, 長谷川潤一

    がん・生殖医療連携ネットワークの全国展開と小児・AYA世代がん患者に対する妊孕性温存の診療体制の均てん化にむけた臨床研究-がん医療の充実を志向して 令和2年度 総括・分担研究報告書(Web)　2021

  6. 【エコチル調査から見えてきた周産期の新たなリスク要因】産科合併症 ソーシャルキャピタル(周囲との人間関係)は,妊娠糖尿病の発症に影響するか?

    水野 聖士, 西郡 秀和, 八重樫 伸生

    臨床婦人科産科　74　(5)　481-486　2020/05

    Publisher: (株)医学書院

    ISSN： 0386-9865

    eISSN： 1882-1294

  7. がん・生殖医療連携ネットワークの全国展開と小児・AYA世代がん患者に対する妊孕性温存の診療体制の均てん化にむけた臨床研究-がん医療の充実を志向して 本邦におけるがんサバイバーの周産期予後等の実態調査とプレコンセプションケア確立に向けた研究

    杉山隆, 池田智明, 太田邦明, 安岡稔晃, 荻島創一, 水野聖士, 岩間憲之

    がん・生殖医療連携ネットワークの全国展開と小児・AYA世代がん患者に対する妊孕性温存の診療体制の均てん化にむけた臨床研究-がん医療の充実を志向して 令和元年度 総括・分担研究報告書(Web)　2020

  8. 妊娠高血圧症候群(HDP)患者の病態分類のためのフェノタイピングアルゴリズムの開発

    水野 聖士, 和形 麻衣子, 永家 聖, 田宮 元, 栗山 進一, 八重樫 伸生, 菅原 準一, 荻島 創一

    日本妊娠高血圧学会雑誌　25　94-94　2018/11

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

  9. 妊娠期間中の飲酒と妊娠高血圧症候群リスクとの関連

    岩間 憲之, 田中 宏典, 目時 弘仁, 西郡 秀和, 水野 聖士, 高橋 史郎, 渡邉 善, 齋藤 昌利, 櫻井 香澄, 石黒 真美, 小原 拓, 龍田 希, 西島 維知子, 杉山 隆, 藤原 幾磨, 栗山 進一, 有馬 隆博, 仲井 邦彦, 八重樫 伸生

    日本妊娠高血圧学会雑誌　25　109-109　2018/11

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

  10. 疫学研究における妊婦の随時血圧と家庭血圧に関する検討 三世代コホート調査

    臼崎 琢磨, 石黒 真美, 小原 拓, 山中 千鶴, 水野 聖士, 永井 雅人, 松原 博子, 菊谷 昌浩, 目時 弘仁, 栗山 進一

    日本高血圧学会総会プログラム・抄録集　41回　YIP-09　2018/09

    Publisher: (NPO)日本高血圧学会

  11. 周辺施設へのアクセシビリティと産後うつとの関連 三世代コホート調査

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    宮城県公衆衛生学会会誌　(50)　30-30　2018/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  12. 周辺環境へのアクセシビリティと産後6ヶ月時点の抑うつ症状との関連:三世代コホート調査

    永井雅人, 水野聖士, 小暮真奈, 石黒真美, 山中千鶴, 松原博子, 小原拓, 小原拓, 菊谷昌浩, 目時弘仁, 目時弘仁, 辻一郎, 呉繁夫, 寳澤篤, 栗山進一, 栗山進一

    日本疫学会学術総会講演集(Web)　28th　85 (WEB ONLY)　2018/02/01

  13. 出生体重と成人期の高血圧有病との関連:東北メディカル・メガバンク計画地域住民コホート調査

    石黒真美, 小原拓, 目時弘仁, 目時弘仁, 菊谷昌浩, 山中千鶴, 水野聖士, 永井雅人, 松原博子, 中谷直樹, 成田暁, 中村智洋, 土屋菜歩, 小暮真奈, 菅原準一, 辻一郎, 呉繁夫, 寳澤篤, 栗山進一

    日本疫学会学術総会講演集(Web)　28th　118 (WEB ONLY)　2018/02/01

  14. 妊娠高血圧症候群(HDP)フェノタイピングのためのアルゴリズムの検討

    水野聖士, 永家聖, 飯田渓太, 笠原直子, 田宮元, 栗山進一, 八重樫伸生, 田中博, 菅原準一, 荻島創一

    日本疫学会学術総会講演集(Web)　28th　133 (WEB ONLY)　2018/02/01

  15. 疾患概念を構造化した妊娠高血圧腎症オントロジー(PEO)の開発

    水野聖士, 西郡秀和, 和形麻衣子, 斎藤昌利, 菅原準一, 菅原準一, 田中博, 八重樫伸生, 八重樫伸生, 荻島創一

    日本妊娠高血圧学会雑誌　24　68-68　2017/09

    Publisher: (一社)日本妊娠高血圧学会

    ISSN： 1880-3172

  16. 東日本大震災後の小児の気管支喘息とアトピー性皮膚炎の再発・悪化

    宮下 真子, 菊谷 昌浩, 山中 千鶴, 水野 聖士, 永井 雅人, 松原 博子, 佐藤 ゆき, 石黒 真美, 小原 拓, 目時 弘仁, 栗山 進一

    東北公衆衛生学会誌　(66)　31-31　2017/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  17. 東日本大震災後の小児の気管支喘息とアトピー性皮膚炎の再発・悪化

    宮下 真子, 菊谷 昌浩, 山中 千鶴, 水野 聖士, 永井 雅人, 松原 博子, 佐藤 ゆき, 石黒 真美, 小原 拓, 目時 弘仁, 栗山 進一

    東北公衆衛生学会誌　(66)　31-31　2017/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  18. 東日本大震災後の宮城県における小中学生の気管支喘息と湿疹の有症率について 東北大学東北メディカル・メガバンク機構地域子ども長期健康調査より

    宮下 真子, 菊谷 昌浩, 田中 彰二, 山中 千鶴, 佐藤 ゆき, 水野 聖士, 石黒 真美, 小原 拓, 目時 弘仁, 成田 暁, 土屋 菜歩, 中村 智洋, 中谷 直樹, 寳澤 篤, 辻 一郎, 栗山 進一

    宮城県公衆衛生学会会誌　(49)　14-14　2017/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  19. 三世代コホート調査における調査票結果回付における情報管理について

    永家聖, 永家聖, 下川和郎, 佐藤ゆき, 石黒真美, 水野聖士, 宮下真子, 山中千鶴, 目時弘仁, 荻島創一, 高井貴子, 栗山進一, 田中博

    日本疫学会学術総会講演集(Web)　27th　116 (WEB ONLY)　2017/01/25

  20. 三世代コホート調査の進捗と子どもの父母の質問票

    目時弘仁, 石黒真美, 石黒真美, 小原拓, 小原拓, 佐藤ゆき, 水野聖士, 水野聖士, 宮下真子, 宮下真子, 菊谷昌浩, 菊谷昌浩, 栗山進一, 栗山進一, 栗山進一, 寳澤篤, 寳澤篤, 大隅典子, 大隅典子, 清元秀泰, 清元秀泰, 菅原準一, 菅原準一, 鈴木洋一, 鈴木洋一, 冨永悌二, 冨永悌二, 布施昇男, 布施昇男, 峯岸直子, 峯岸直子, 辻一郎, 辻一郎, 呉繁夫, 呉繁夫, 八重樫伸生, 八重樫伸生, 山本雅之, 山本雅之

    Journal of Epidemiology (Web)　26　(Supplement 1)　105　2016/01/21

    ISSN： 1349-9092

  21. 満期産児の臍帯血赤血球脂肪酸組成におけるdesaturase活性指標と出生体重SDスコアーについて

    長野 伸彦, 岡田 知雄, 阿部 百合子, 細野 茂春, 高橋 滋, 斉藤 恵美子, 岩田 富士彦, 原 光彦, 高橋 昌里, 川端 輝江, 仲井 邦彦, 水野 聖士, 齋藤 彰治, 有馬 隆博, 八重樫 伸生

    The Lipid　26　(2)　209-209　2015/04

    Publisher: (株)メディカルレビュー社

    ISSN： 0915-6607

  22. 妊娠女性の末梢血赤血球ω3系不飽和脂肪酸の決定因子 エコチル調査の追加調査から

    仲井 邦彦, 齋藤 彰治, 龍田 希, 川端 輝江, 木村 ふみ子, 水野 聖士, 西郡 秀和, 有馬 隆博, 八重樫 伸生

    日本衛生学雑誌　70　(Suppl.)　S220-S220　2015/03

    Publisher: (一社)日本衛生学会

    ISSN： 0021-5082

    eISSN： 1882-6482

  23. 胎盤組織における長鎖不飽和脂肪酸生合成に関わる中間代謝物の解析 出生コホート調査(エコチル調査の追加調査)での検討

    山崎 潔大, 木村 ふみ子, 仲川 清隆, 川端 輝江, 仲井 邦彦, 有馬 隆博, 水野 聖士, 八重樫 伸生, 宮澤 陽夫

    脂質栄養学　23　(2)　152-152　2014/08

    Publisher: 日本脂質栄養学会

    ISSN： 1343-4594

  24. 魚介類摂取のリスクとベネフィット ω3不飽和脂肪酸と出生児の各種指標との関連

    仲井 邦彦, 齋藤 彰治, 龍田 希, 下田 和美, 川端 輝江, 水野 聖士, 木村 ふみ子, 宮澤 陽夫, 有馬 隆博, 八重樫 伸生

    日本衛生学雑誌　69　(Suppl.)　S247-S247　2014/05

    Publisher: (一社)日本衛生学会

    ISSN： 0021-5082

    eISSN： 1882-6482

  25. 母体血および臍帯血赤血球中脂肪酸組成と非妊娠時BMIとの関連

    下田 和美, 川端 輝江, 香川 靖雄, 木村 ふみ子, 宮澤 陽夫, 仲井 邦彦, 有馬 隆博, 水野 聖士, 八重樫 伸生

    日本栄養・食糧学会大会講演要旨集　68回　272-272　2014/04

    Publisher: (公社)日本栄養・食糧学会

  26. エコチル調査・宮城ユニットセンターにおける妊婦の医薬品使用状況の評価-宮城ユニットセンター薬剤詳細調査より-

    西郡 秀和, 小原 拓, 目時 弘仁, 石黒 真美, 水野 聖士, 櫻井 香澄, 岩間 憲之, 村井 ユリ子, 杉山 隆, 菅原 準一, 眞野 成康, 栗山 進一, 八重樫 伸生

    DOHaD研究　3　(1)　49-49　2014

    Publisher: 日本DOHaD研究会

    ISSN： 2187-2597

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    第3回日本DOHaD研究会学術集会 抄録集 【ポスター発表】

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Research Projects 4

  1. 遺伝・環境要因相互作用を捉える人工知能に基づく疾患関連因子の全体像理解の手法開発

    水野 聖士

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2024/04/01 - 2028/03/31

  2. Systems pathology approach using deep learning to understand the effect of environmental exposure on the pathogenesis of common diseases

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2021/04/01 - 2024/03/31

  3. 多因子疾患の立体的な層別化に基づく臨床的多様性の詳細な理解の手法の開発

    水野 聖士

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 若手研究

    Category: 若手研究

    Institution: 東北大学

    2020/04/01 - 2023/03/31

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    本年度は、東北メディカル・メガバンク計画三世代コホート調査参加者のうち妊娠高血圧症候群（HDP）患者約二千名を対象に、前年度に同定した有害アウトカムであるLight-for-date（LFD）および降圧剤への治療抵抗性の有無を正解ラベルとした機械学習モデルで取得した有害アウトカムに関連する特徴を使用し、以下の研究を実施した。 1. コミュニティ検出, 2. 検出したコミュニティの評価, 3. 検出したコミュニティで特徴的なクラスタに関連する特徴の同定 1. は、有害アウトカムに関連する特徴を入力とし、K近傍法による近傍の探索とjaccard coefficientでの類似度に基づく対象者のネットワークの構築とlouvain法とleiden法によるコミュニティ検出を実施した。 2. は、検出したコミュニティのうち、有害アウトカムに関連するものを対象に、 クラスタごとに、早産リスク、低出生体重リスク、有害アウトカムのリスク、妊娠期間をターゲットとした生存時間解析のlogrank p-valueおよびhazard ratio、割合の多い病型を評価し、HDPの臨床的多様性に対応するクラスタを取得した。3. は、2.で取得したクラスタを目的変数とした、1.で使用したすべての有害アウトカムに関連する特徴を対象に単変量解析を実施し、HDPの臨床的多様性に対応するクラスタに関連する特徴を取得した。 来年度は、今年度に実施できなかった、HDPの臨床的多様性に対応するクラスタに関連する特徴の評価と、遺伝情報と曝露情報による層別化の組み合わせで定義されるサブクラスを目的変数とした２因子間の相互作用解析および、遺伝情報と曝露情報の相互情報量を使用し構築したネットワーク上での、相互作用のある因子の背景構造の同定を行う。

  4. Buildling of work-flow to develop machine learning model for prediction of Hypertensive disorders of pregnancy (HDP)

    SATOSHI MIZUNO

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

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    We considered the work-flow to develop supervised machine learning model for prediction of hypertensive disorders of pregnancy (HDP) with large-scale birth cohort dataset. To obtain class-label of supervised learning, we developed rule-based phenotyping algorithm according to clinical guidelines. The developed algorithm was applied into phenotyping of Birthree cohort subjects. We tried to develop the ML model to predict HDP with phenotyped disease types as class labels of supervised machine learning. In this study, we used Birthree cohort data before data-cleaning to develop the work-flow. In the future work, we will study with data after cleaning to develop precise informatics bases of HDP study in Birthree cohort study.