Details of the Researcher

PHOTO

Tatsunori Ito
Section
Graduate School of Medicine
Job title
Assistant Professor
e-Rad No.
20989181

Awards 3

  1. 喘息研究支援プログラムB

    2023　日本呼吸器学会

  2. 2021年 JRS Young Scientist Award

    2021

  3. 2021年 APSR Assembly Education Award

Papers 7

  1. Pharmacist Intervention Preventing Severe Cytokine Release Syndrome Induced by Immune Checkpoint Inhibitor Therapy: A Case Report Peer-reviewed

    Taiga Ishikawa, Masaki Kumondai, Ryo Yamada, Yurika Ishida, Hiroko Nishibeppu, Tatsunori Ito, Masamitsu Maekawa, Toshiaki Igarashi, Nariyasu Mano

    YAKUGAKU ZASSHI　146　(6)　611-614　2026/06/01

    Publisher: Pharmaceutical Society of Japan

    DOI： 10.1248/yakushi.25-00188 　

    ISSN： 0031-6903

    eISSN： 1347-5231

  2. 原発部位が生存転帰と再発形式に与える影響 III期非小細胞肺がん患者の後方視観察研究

    岩崎 史, 宮内 栄作, 山本 貴也, 田中 寿志, 布村 恭仁, 畑山 佳臣, 守田 亮, 福井 伸, 伊藤 辰徳, 突田 容子, 渋谷 里紗, 杉浦 久敏

    肺癌　65　(5)　435-435　2025/11

    Publisher: (NPO)日本肺癌学会

    ISSN： 0386-9628

    eISSN： 1348-9992

  3. ES-SCLCに対するプラチナ製剤+免疫チェックポイント阻害剤におけるG-CSFの1次予防についての検討

    渋谷 里紗, 中鉢 敬, 田中 寿志, 牧口 友紀, 伊藤 辰徳, 宮内 栄作, 長谷川 幸裕, 田坂 定智

    肺癌　65　(5)　449-449　2025/11

    Publisher: (NPO)日本肺癌学会

    ISSN： 0386-9628

    eISSN： 1348-9992

  4. 特発性肺線維症における組織常在性マクロファージの分子プロファイルと前腫瘍微小環境形成機序の解明

    藤野 直也, 齋藤 拓矢, 今野 周一, 小野 祥直, 伊藤 辰徳, 突田 容子, 渋谷 里紗, 宮内 栄作, 山田 充啓, 杉浦 久敏

    肺癌　65　(5)　443-443　2025/11

    Publisher: (NPO)日本肺癌学会

    ISSN： 0386-9628

    eISSN： 1348-9992

  5. CYP27A1-27-hydroxycholesterol axis in the respiratory system contributes to house dust mite-induced allergic airway inflammation. International-journal Peer-reviewed

    Tatsunori Ito, Tomohiro Ichikawa, Mitsuhiro Yamada, Yuichiro Hashimoto, Naoya Fujino, Tadahisa Numakura, Yusaku Sasaki, Ayumi Suzuki, Katsuya Takita, Hirohito Sano, Yorihiko Kyogoku, Takuya Saito, Akira Koarai, Tsutomu Tamada, Hisatoshi Sugiura

    Allergology international : official journal of the Japanese Society of Allergology　73　(1)　151-163　2024/01

    DOI： 10.1016/j.alit.2023.08.005 　

    More details Close

    BACKGROUND: 27-Hydroxycholesterol (27-HC) derived from sterol 27-hydroxylase (CYP27A1) has pro-inflammatory biological activity and is associated with oxidative stress and chronic inflammation in COPD. However, the role of regulation of CYP27A1- 27-HC axis in asthma is unclear. This study aimed to elucidate the contribution of the axis to the pathophysiology of asthma. METHODS: House dust mite (HDM) extract was intranasally administered to C57BL/6 mice and the expression of CYP27A1 in the airways was analyzed by immunostaining. The effect of pre-treatment with PBS or CYP27A1 inhibitors on the cell fraction in the bronchoalveolar lavage fluid (BALF) was analyzed in the murine model. In vitro, BEAS-2B cells were treated with HDM and the levels of CYP27A1 expression were examined. Furthermore, the effect of 27-HC on the expressions of E-cadherin and ZO-1 in the cells was analyzed. The amounts of RANTES and eotaxin from the 27-HC-treated cells were analyzed by ELISA. RESULTS: The administration of HDM increased the expression of CYP27A1 in the airways of mice as well as the number of eosinophils in the BALF. CYP27A1 inhibitors ameliorated the HDM-induced increase in the number of eosinophils in the BALF. Treatment with HDM increased the expression of CYP27A1 in BEAS-2B cells. The administration of 27-HC to BEAS-2B cells suppressed the expression of E-cadherin and ZO-1, and augmented the production of RANTES and eotaxin. CONCLUSIONS: The results of this study suggest that aeroallergen could enhance the induction of CYP27A1, leading to allergic airway inflammation and disruption of the airway epithelial tight junction through 27-HC production.

  6. Role of reactive persulfide species in influenza virus-induced lung inflammation

    Tomohiro Ichikawa, Katsuya Takita, Tatsunori Ito, Yorihiko Kyogoku, Tadahisa Numakura, Mitsuhiro Yamada, Takaaki Akaike, Masakazu Ichinose, Hisatoshi Sugiura

    RESPIROLOGY　26　9-10　2021/11

    ISSN： 1323-7799

    eISSN： 1440-1843

  7. Molecular dynamics simulations for microscopic behavior of water molecules in the vicinity of zwitterionic self-assembled monolayers

    Ryo Nagumo, Tatsunori Ito, Kazuki Akamatsu, Ryuji Miura, Ai Suzuki, Hideyuki Tsuboi, Nozomu Hatakeyama, Hiromitsu Takaba, Akira Miyamoto

    POLYMER JOURNAL　44　(11)　1149-1153　2012/11

    DOI： 10.1038/pj.2012.72 　

    ISSN： 0032-3896

    eISSN： 1349-0540

Show all ︎Show first 5

Misc. 5

  1. 肺癌患者におけるFoundationOne検査の現状と提出検体の違いによる治療提案率の検討

    宮内 栄作, 山本 友梨, 成田 大輔, 木村 望, 伊藤 辰徳, 突田 容子, 渋谷 里紗, 杉浦 久敏

    気管支学　47　(Suppl.)　S244-S244　2025/05

    Publisher: (一社)日本呼吸器内視鏡学会

    ISSN： 0287-2137

    eISSN： 2186-0149

  2. 当科における肺癌患者の包括的がんゲノムプロファイリング検査(CGP)症例の現況

    成田 大輔, 渋谷 里紗, 宮内 栄作, 突田 容子, 伊藤 辰徳, 木村 望, 玉田 勉, 杉浦 久敏

    肺癌　64　(5)　498-498　2024/10

    Publisher: (NPO)日本肺癌学会

    ISSN： 0386-9628

    eISSN： 1348-9992

  3. 当院における進行期非小細胞肺癌患者に対する院内AMOY遺伝子変異検査の検査成功率とTurn Around Timeの検討

    岩崎 史, 宮内 栄作, 井上 千裕, 青山 弥生, 小泉 照樹, 渋谷 里紗, 突田 容子, 木村 望, 伊藤 辰徳, 小野 祥直, 松本 周一郎, 成田 大輔, 遠藤 卓人, 鈴木 眞奈美, 野津田 泰嗣, 小野寺 賢, 岡田 克典

    気管支学　46　(Suppl.)　S292-S292　2024/05

    Publisher: (一社)日本呼吸器内視鏡学会

    ISSN： 0287-2137

    eISSN： 2186-0149

  4. 早期からの集学的治療により喀痰培養陰性化を得た線維空洞型肺M.avium症の1例

    遠藤 卓人, 藤野 直也, 今野 周一, 竹田 俊一, 小野 祥直, 佐野 寛仁, 伊藤 辰徳, 山田 充啓, 杉浦 久敏

    結核　99　(2)　63-67　2024/03

    Publisher: (一社)日本結核・非結核性抗酸菌症学会

    ISSN： 0022-9776

    eISSN： 1884-2410

  5. 今月の症例 肉芽腫を越えて肺胞腔への進展を示したコクシジオイデス症の1例

    佐野 寛仁, 藤野 直也, 齊藤 涼子, 山田 充啓, 玉田 勉, 齋藤 拓矢, 伊藤 辰徳, 亀井 克彦, 杉浦 久敏

    日本内科学会雑誌　111　(7)　1422-1427　2022/07

    Publisher: (一社)日本内科学会

    ISSN： 0021-5384

    eISSN： 1883-2083

Presentations 4

  1. A prospective multicenter phase II study of rechallenge treatment with ramucirumab plus erlotinib in patients with EGFR-mutated, advanced non-small cell lung cancer (NJLCG2102) International-presentation

    Ryota Saito, Tatsunori Ito, Yoko Tsukita, Taku Nakagawa, Hisashi Tanaka, Koichiro Nozaki, Minehiko Inomata, Kana Watanabe, Megumi Furuta, Ryo Morita, Naruo Yoshimura, Eisaku Miyauchi, Hisatoshi Sugiura

    ESMO Congress 2026　2026/10/23

  2. Impact of HER2 aberrations on first-line osimertinib efficacy in EGFR-mutant advanced NSCLC: the HERITAGE study International-presentation

    Ryota Kurebayashi, Tatsunori Ito, Eisaku Miyauchi, Motohiro Tamiya, Yoshihiko Sakata, Reina Hara, Hirotaka Matsumoto, Hiroshi Kobe, Go Saito, Taiichiro Otsuki, Teppei Yamaguchi, Megumi Inaba, Hirotaka Maruyama, Eri Takase, Shinya Sakata, Shinsuke Tsumura, Takeshi Katsurashima, Takeshi Mera, Hisatoshi Sugiura

    ESMO Congress 2026　2026/10/23

  3. Efficacy of Immune Checkpoint Inhibitor Combination Chemotherapy in Patients with Recurrent Non-Small Cell Lung Cancer after Durvalumab Consolidation Following Chemoradiotherapy: A Multicenter Retrospective Study (NEJ066) International-presentation

    Suguru Matsuda, Hirokazu Iso, Ryota Saito, Masahiro Kashima, Toshiyuki Sumi, Hiroaki Ikushima, Gen Kida, Hisashi Tanaka, Tatsunori Ito, Ayana Suzuki, Hironori Ashinuma, Yasuhiro Kato, Ken Masubuchi, Yukiko Namba, Ayako Takigami, Kazuhiro Usui, Satoshi Morita, Makoto Maemondo, Yuji Minegishi, Masahiro Seike

    ESMO Asia Congress 2025　2025/12/05

  4. The Role of 27-Hydroxycholesterol in the Pathogenesis of Bronchial Asthma International-presentation

    Tatsunori Ito, Tomohiro Ichikawa, Katsuya Takita, Mitsuhiro Yamada, Masakazu Ichinose, Hisatoshi Sugiura

    American Thoracic Society International Conference 2021 (ATS 2021)　2021/05/14