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Shuto Osaki

Section

Graduate School of Engineering

Job title

Assistant Professor

Degree

Ph.D (Osaka University)

researchmap

https://researchmap.jp/shuto_osaki1919510

J-GLOBAL ID

202201006317955170

e-Rad No.

40966082

ORCID

https://orcid.org/0000-0003-0136-2284

Research History 8

2024/10 - Present

東北大学工学研究科ファインメカニクス専攻　助教
2023/04 - 2024/09

National Institute of Advanced Industrial Science and Technology
2021/04 - 2022/03

Japan Society for the Promotion of Science
2024/07 - 2024/09

SANKEN, Osaka Univ.
2022/06 - 2024/09

Osaka University　Graduate School of Engineering
2022/04 - 2023/03

National Institute of Advanced Industrial Science and Technology
2017/04 - 2022/03

National Institute of Advanced Industrial Science and Technology
2016/04 - 2017/03

National Institute of Advanced Industrial Science and Technology

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Education 3

Osaka University　Graduate School of Engineering　Department of Applied Physics

2019/04 - 2022/03
Kobe University　Graduate School of Human Development and Environment

2017/04 - 2019/03
Osaka Institute of Technology　Faculty of Engineering　Department of Applied Chemistry

2013/04 - 2017/03

Committee Memberships 1

日本分析化学会東北支部　幹事

2026/03 - Present

Professional Memberships 3

応用物理学会

2019/08 - Present
日本電気化学会

2019/04 - Present
日本分析化学会

2017/04 - Present

Research Interests 3

金属ナノ材料
biosensor
electroanalysis

Research Areas 3

Manufacturing technology (mechanical, electrical/electronic, chemical engineering) / Applied biofunctional and bioprocess engineering /
Life sciences / Biomedical engineering /
Nanotechnology/Materials / Nanobioscience /

Awards 2

S&M Young Researcher Paper Award 2022

2023/02　Sensors and Materials
東北支部助成金

2025/12　公益財団法人日本分析化学会東北支部　界面の綿密設計による長期安定型イオン選択性電界効果トランジスタ

Papers 19

Wireless electrochemiluminescence biosensor for organophosphorus compounds using a smartphone camera and a wirelessly transmitted voltage device Peer-reviewed

Eiichi Tamiya, Shuto Osaki, Masahiro Tokumura, Masakazu Makino, Noriko Ueda, Hidenori Nagai

Sensors and Actuators B: Chemical　2026/03

DOI： 10.1016/j.snb.2025.139275 　
Surface Modification of Screen-Printed Carbon Electrode through Oxygen Plasma to Enhance Biosensor Sensitivity

Shuto Osaki, Masato Saito, Hidenori Nagai, Eiichi Tamiya

Biosensors　2024/02/06

DOI： 10.20944/preprints202402.0307.v1 　
Point-of-Care Diagnostic Biosensors to Monitor Anti-SARS-CoV-2 Neutralizing IgG/sIgA Antibodies and Antioxidant Activity in Saliva Invited Peer-reviewed

Eiichi Tamiya, Shuto Osaki, Tomoko Tsuchihashi, Hiromi Ushijima, Keiichi Tsukinoki

Biosensors　2023/01/20

DOI： 10.3390/bios13020167 　
Fully organic waterproof biobattery designed for mouthpiece applications Peer-reviewed

Mirai Matsuura, Sae Suzuki, Haechang Cho, Shuto Osaki, Soichiro Tottori, Matsuhiko Nishizawa

Biomedical Microdevices　28　(2)　2026/05/14
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s10544-026-00822-0 　

ISSN： 1387-2176

eISSN： 1572-8781
Water-Triggered Self-Wrapping and Immobilization of an All-Organic Hydrogel-Based Cuff Electrode Peer-reviewed

Shin-ichiro Osawa, Fumiya Imamura, Natsuki Nozaki, Tenyo Ko, Shuto Osaki, Soichiro Tottori, Atsuhiro Nakagawa, Matsuhiko Nishizawa

Materials Today Bio　102248-102248　2025/08
Publisher: Elsevier BV
DOI： 10.1016/j.mtbio.2025.102248 　

ISSN： 2590-0064
Porous Microneedles: Transdermal Salt Bridge for Biomedical Device Engineering Peer-reviewed

Gaobo Wang, Yuina Abe, Soichiro Tottori, Shuto Osaki, Matsuhiko Nishizawa

Current Opinion in Biomedical Engineering　100593-100593　2025/05
Publisher: Elsevier BV
DOI： 10.1016/j.cobme.2025.100593 　

ISSN： 2468-4511
Wireless electrochemiluminescent biosensors: Powering innovation with smartphone technology Invited Peer-reviewed

Eiichi Tamiya, Shuto Osaki, Hidenori Nagai

Biosensors and Bioelectronics　2024/02

DOI： 10.1016/j.bios.2024.116083 　

ISSN： 0956-5663
Development of Electrochemical Biosensors by Modification of Functional Molecules on Electrode Surfaces Invited

Shuto OSAKI, Shin-ichi WAKIDA, Eiichi TAMIYA

Journal of The Surface Finishing Society of Japan　74　(2)　99-105　2023/02/01
Publisher: The Surface Finishing Society of Japan
DOI： 10.4139/sfj.74.99 　

ISSN： 0915-1869

eISSN： 1884-3409
Investigation of Drift in Polyurethane Matrices for Salivary Nitrate Ion-selective Field-effect Transistors Peer-reviewed

Shuto Osaki, Kenichi Kitamura, Takuya Kintoki, Takayo Moriuchi-Kawakami, Shin-ichi Wakida

Sensors and Materials　34　(11)　4209-4209　2022/11/30
Publisher: MYU K.K.
DOI： 10.18494/sam4105 　

ISSN： 0914-4935

eISSN： 2435-0869
Fully Transparent, Ultrathin Flexible Organic Electrochemical Transistors with Additive Integration for Bioelectronic Applications International-journal Peer-reviewed

Ashuya Takemoto, Teppei Araki, Kazuya Nishimura, Mihoko Akiyama, Takafumi Uemura, Kazuki Kiriyama, Johan M. Koot, Yuko Kasai, Naoko Kurihira, Shuto Osaki, Shin‐ichi Wakida, Jaap M.J. den Toonder, Tsuyoshi Sekitani

Advanced Science　10　(2)　2204746-2204746　2022/11/14
Publisher: Wiley
DOI： 10.1002/advs.202204746 　

ISSN： 2198-3844

eISSN： 2198-3844

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Optical transparency is highly desirable in bioelectronic sensors because it enables multimodal optical assessment during electronic sensing. Ultrathin (<5 µm) organic electrochemical transistors (OECTs) can be potentially used as a highly efficient bioelectronic transducer because they demonstrate high transconductance during low-voltage operation and close conformability to biological tissues. However, the fabrication of fully transparent ultrathin OECTs remains a challenge owing to the harsh etching processes of nanomaterials. In this study, fully transparent, ultrathin, and flexible OECTs are developed using additive integration processes of selective-wetting deposition and thermally bonded lamination. These processes are compatible with Ag nanowire electrodes and conducting polymer channels and realize unprecedented flexible OECTs with high visible transmittance (>90%) and high transconductance (≈1 mS) in low-voltage operations (<0.6 V). Further, electroencephalogram acquisition and nitrate ion sensing are demonstrated in addition to the compatibility of simultaneous assessments of optical blood flowmetry when the transparent OECTs are worn, owing to the transparency. These feasibility demonstrations show promise in contributing to human stress monitoring in bioelectronics.
Optimization of electrochemical analysis for signal amplification in gold nanoparticle-probed immunoassays Peer-reviewed

Shuto Osaki, Wilfred Villariza Espulgar, Shin-ichi Wakida, Masato Saito, Eiichi Tamiya

Electrochimica Acta　141180-141180　2022/11
Publisher: Elsevier BV
DOI： 10.1016/j.electacta.2022.141180 　

ISSN： 0013-4686
Gold Nanocatalysts Towards Digital Sensing Probes with Electrochemiluminescence Based Micro Electrodes Array Peer-reviewed

Nagano, K., Terada, Y., Araki, A., Osaki, S., Saito, M., Tamiya, E.

Electroanalysis　34　(1)　8-14　2022/01
Publisher: Wiley
DOI： 10.1002/elan.202100312 　

ISSN： 1521-4109 1040-0397
Development of the Sensor Part Re-composition on the Salivary NO₃ ⁻ Measurement Device for the Evaluation of Mental Workload Peer-reviewed

Kenichi Kitamura, Koji Murai, Shin-ichi Wakida, Shuto Osaki, Takuya Kintaki

2021 World Automation Congress (WAC)　2021/08/01
Publisher: IEEE
DOI： 10.23919/wac50355.2021.9559481 　
Towards On-site Determination of Secretory IgA in Artificial Saliva with Gold-Linked Electrochemical Immunoassay (GLEIA) Using Portable Potentiostat and Disposable Printed Electrode Invited Peer-reviewed

Osaki, S., Wakida, S.-I., Saito, M., Tamiya, E.

Applied Biochemistry and Biotechnology　193　(5)　1311-1320　2021/05
Publisher: Springer Science and Business Media {LLC}
DOI： 10.1007/s12010-020-03332-8 　

ISSN： 1559-0291 0273-2289
Application of Polymer-Based Nitrate Ion-Sensitive Field-Effect Transistors to On-site Measurement of Mental Workload Peer-reviewed

KITAMURA Kenichi, MURAI Koji, WAKIDA Shin-ichi, KINTOKI Takuya, OSAKI Shuto

Transactions of Navigation　6　(1)　1-9　2021
Publisher: Japan Institute of Navigation
DOI： 10.18949/jintransnavi.6.1_1 　

ISSN： 2189-5511

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The primary aim of our research is to complete physiological index to evaluate mental workload. We focus on salivary NO₃^- as an index, which is emitted to blood vessels from vascular endothelial cells when a human body receives mental workload. The development of a device to measure NO₃^- in vascular endothelial cells is thus required for the evaluation of mental workload. The device developed here is composed of field-effect transistors and ion-selective membranes. We have adopted a polymer for use with an ion-selective membrane. Two experiments were performed to verify the drift in the device characteristics and to validate the characteristics of the polymer as the ion-selective membrane. Verified experimental results indicated that the polymer was useful as ion-selective membrane material, which has less drift characteristics for a long time measurement. Validated experimental results indicated that NO₃^- device with new polymer KP-13 has the effectiveness of measurement of mental workload on the spot, compared with values from NO₃^- device with KP-13 and other physiological indices.
On-Site and Daily Stress-Measurement Using Gold-Linked Electrochemical Immuno Assay for IgA Determination

Shuto Osaki, Shin-ichi Wakida, Masato Saito, Eiichi Tamiya

ECS Meeting Abstracts　MA2020-01　(27)　1891-1891　2020/05/01
Publisher: The Electrochemical Society
DOI： 10.1149/MA2020-01271891mtgabs 　

eISSN： 2151-2043

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[Introduction] Mental stress is closely connected with our physical and mental wellness. In particular, depression may be associated with stress. Therefore, stress measurement can contribute to assess our lifestyle and increase our quality of life. However, objective stress-measurement is not established. To establish objective stress-measurement, an individual must indicate the stress level by obtaining numerous data continuously throughout the day. Therefore, the measurement method which can be suitable for this condition is needed. In this paper, we detect the secretory Immunoglobulin A (sIgA), which is the candidate of salivary stress-markers, with original electrochemical immunoassay: Gold-Linked Electrochemical Immuno Assay (GLEIA). This biosensor is based on a sandwich-type immunosensor, and adopt the electrochemical method to detect the reduction peak from Au nanoparticles linked to the secondary antibody. GLEIA is convenient and cost-effective that only requires low sample volume (10 µL). In addition, all devices that GLEIA needs are minimal such as note PC and portable potentiostat and printed electrode. Therefore, GLEIA method shows various advantages suitable for stress measurement as compared with other sIgA detection methods. In this paper, we aim to the on-site and continuous measurement of salivary IgA in our daily life, to determine the various concentration of sIgA in standard solution and artificial saliva using GLEIA. [Experimental] Primary Anti-IgA Antibody solution was dropped onto the working electrode for immobilizing the antibody by physical adsorption. After, the Au nanoparticle solution was mixed with the phosphate buffer (50 mM, pH=8.3). The anti-IgA to dissolve the 5 mM of phosphate buffer add the Au nanoparticle solution. For the preparing of secondary antibody modified Au nanoparticle, the antibody was conjugated with Au nanoparticle under the pH=8.3 condition and kept for 10 min at room temperature. Then, 10% BSA in PBS buffer and 1% PEG in PBS buffer were added in preparing Au solution. Finally, the concentration was adjusted for OD520=6.0 by centrifuge and exclude the supernatant. The Au Anti-IgA conjugate was diluted by 3 times with 50 w/v of trehalose (OD520=2) and dripping 5µL of this solution in the immunomodule. Then the immunomodule was dried in vacuum condition for 5 minutes. Dried immunomodule was stored at 4 ℃ until use. Different concentrations of the IgA antigen solution (0, 10, 60, 150, 300 ng/mL) were made by diluting in PBS. For the detection of Antibody-Antigen reaction, the IgA solutions were mixed in prepared immunomodule, After the 1 minute, and 1.4 µL of the solution was placed on immunosensor to incubate for 1 hour, after rinsing with PBS, and eliminate the PBS solution with the air gun. The direct redox reaction was performed in 2M KCl solution (20 µL) covering the entire three-electrode zone at room temperature. [Results and Discussion] We obtained the linear response to relate the concentration of sIgA (10-300 ng/mL) in D-PBS buffer with the artificial-saliva which includes salivary inorganic salt and typically glycoprotein (mucin). Figure 1 shows the differential pulse voltammogram of GLEIA with IgA in artificial saliva (a) and calibration curve (b). In addition, the calibration curve shows the linear range within 10-300 ng/mL and the correlation coefficient (R2) of the calibration curve for this relationship was 0.963. The peak current intensity is decreased from in standard solution. It may prevent the Antigen-Antibody reaction from artificial saliva which pH is nearly 8.5. Generally, the antibody shows the best affinity in pH= 6.5~8.4 condition. However, these results show that GLEIA is suitable for salivary IgA detection because the salivary pH is mainly neutral. Furthermore, we evaluate the selectivity of the immunosensor by comparing it with the reduction peak between IgA= 300ng/mL or 0 ng/mL and interference protein such as α-amylase, human serum albumin, immunoglobulin G (IgG), lysozyme and mucin. We acknowledge GLEIA shows the signal increasing within the existence of interference proteins. This may be the affinity of antibody and non-specific reaction between antibody and the proteins. More importantly, we recognize that the reduction peak is increasing with the concentration of sIgA in the existence of interference proteins. Therefore, GLEIA can be applied for stress measurement using salivary sIgA that can be used in daily life anywhere and anytime whenever necessary. In the future, we try to detect the sIgA in real saliva for on-site stress measurement using GLEIA and to integrate the various immunosensors for stress-markers in saliva.nd anytime whenever necessary. In the future, we try to detect the sIgA in real saliva for on-site stress measurement using GLEIA and to integrate the various immunosensors for stress-markers in saliva. Figure 1
Verification of a Stability of Polymer Matrix for the Salivary-Nitrate-ISFETS

Shuto Osaki, Takuya Kintoki, Takayo Moriuchi, Kenichi Kitamura, Shin-ichi Wakida

ECS Meeting Abstracts　2019/09/01

DOI： 10.1149/MA2019-02/51/2232 　
Investigation of Polyurethane Matrix Membranes for Salivary Nitrate ISFETs to Prevent the Drift Peer-reviewed

Shuto Osaki, Takuya Kintoki, Takayo Moriuchi-Kawakami, Kenichi Kitamura, Shin-ichi Wakida

Sensors　19　(12)　2713-2713　2019/06/17
Publisher: MDPI AG
DOI： 10.3390/s19122713 　

ISSN： 1424-8220

eISSN： 1424-8220
Development of Stable ISFETs for Salivary Nitrate to Acute Stress Monitoring Peer-reviewed

S. Wakida, S. Osaki, T. Kintoki, K. Kitamura

Proc. 17th International Meeting on Chemical Sensors　433-434　2018/07

DOI： 10.5162/IMCS2018/FE.6

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Misc. 35

金ナノ材料修飾印刷電極を用いた使い捨て型PFOSアプタセンサ

大﨑脩仁, 寺田侑平, 青木寛

電気化学第９３回大会　2026/03
多孔質マイクロニードルによる非侵襲型体液抽出のための逆イオントフォレシス

酒井郁佳, 大﨑脩仁, 稲本陽太, 石川航太郎, 赤石大輔, 鳥取聡一郎, 西澤松彦

第35回日本MRS年次大会　2025/11
Advanced Transdermal Drug Delivery Using Porous Microneedle with Electroosmonic Flow

Shuto Osaki, Fumika Sakai, Ishikawa Kotaro, Daisuke Akaishi, Soichiro Tottori, Matsuhiko Nishizawa

2nd International Workshop on Bioelectrochemisty (2nd BES Workshop)　2025/09
電気浸透流を利用した多孔性マイクロニードルによる高度経皮薬物送達

大﨑脩仁, 酒井郁佳, 石川航太郎, 赤石大輔, 鳥取総一郎, 西澤松彦

2025電気化学秋季大会　2025/09
効率的な経皮投薬のためのマイクロニードルの絶縁コーティング

石川航太郎, 一瀬彩栄, 酒井郁佳, 森山夏帆, 鳥取聡一郎, 大﨑脩仁, 西澤松彦

化学とマイクロ・ナノシステム学会第51回研究会　2025/05
神経束に自己固定可能なハイドロゲル製カフ型電極の開発

野﨑菜月, 今村文哉, 鳥取聡一郎, 大﨑脩仁, 大沢伸一郎, 安斎優希, 立川樹璃, 神崎展, 中川敦, 寛, 西澤松彦

化学とマイクロ・ナノシステム学会第51回研究会　2025/05
生体イオントロニクスデバイスの研究と開発-8

西澤松彦, 鳥取聡一郎, 大﨑脩仁

電気化学第92回大会　2025/03
金ナノ粒子を用いた電気化学バイオセンサの開発と被験者応用

大﨑脩仁

第55回セミコンファレンス第37回東北若手の会　2024/12
スマートグラスを使用した航海補助システムの開発

小新琉依, 北村健一, 瀨田広明, 大﨑脩仁

2024年度日本人間工学会関西支部大会講演論文集　2024/11
金ナノ材料の特異な電気化学特性を用いたバイオセンサ開発

大﨑脩仁, 民谷栄一

第18回バイオ関連化学シンポジウム要旨集　2024/09
電解重合ルミノール印刷電極を用いた電気化学発光バイオセンサーの開発

民谷栄一, 大﨑脩仁, 永井秀典

電気化学第91回大会　2024/03
ワイヤレス電力伝送を用いた電気化学発光センサーによるバイオマーカー計測

民谷栄一, 大﨑脩仁, 永井秀典

2024年第71回応用物理学会春季学術講演会　2024/03
ナノ構造の異なる金粒子の電気化学特性とバイオセンサ応用

大﨑脩仁, 永井秀典, 民谷栄一

電気化学第91回大会　2024/03
243rd ECS Meeting Participation Report Invited

Shuto OSAKI

Denki Kagaku　91　(4)　441-441　2023/12/05
Publisher: The Electrochemical Society of Japan
DOI： 10.5796/denkikagaku.23-ot0060 　

ISSN： 2433-3255

eISSN： 2433-3263
海中転落者への迅速で直接的な救助の検討

北村健一, 瀬田広明, 山田智貴, 大﨑脩仁

2023年度日本人間工学会関西支部大会講演論文集　25-26　2023/12
グラフェン修飾印刷電極を用いた金ナノ粒子の電気化学特性評価

大﨑脩仁, 永井秀典, 民谷栄一

2023電気化学秋季大会　2023/09
EIS and Amperometric Analysis of Gold Nanoparticle Probes on the Immunosensor Surface

Shuto Osaki, Wilfred Villariza Espulgar, Masato Saito, Eiichi Tamiya

ECS Meeting Abstracts　MA2023-01　(48)　2532-2532　2023/08/28
Publisher: The Electrochemical Society
DOI： 10.1149/ma2023-01482532mtgabs 　

eISSN： 2151-2043

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[Introduction] Biosensing systems with integrated nanomaterials have revolutionized technological advancements in recent decades. Gold nanoparticles (AuNPs) in particular have been widely used in electrochemical sensors owing to their stability and unique characteristics. Previously, we developed biosensors that utilize the redox activity of AuNPs. Briefly, antibody-modified AuNPs not only hold secondary antibodies to react with antigens and primary antibodies on the electrode but also supply redox signals. We specially call this biosensing method Gold-Linked Electrochemical ImmunoAssay (GLEIA). In recent years, GLEIA has evolved uniquely in combination with other nanomaterials. However, information regarding the optimal electrochemical measurement conditions and the relationship between the electrode surface and AuNPs remain unknown. In this study, we quantitatively determined kinetic parameters such as the diffusion coefficient and electron transfer rate in the redox reaction of AuNPs on disposable screen-printed electrodes. Furthermore, the relationship between the addition of antibodies and the decrease in the determined parameters could be deduced. This is useful for the determination of the fine balance between the sensitivity and specificity. [Experimental] Electrochemical characteristics of AuNPs were performed using the following method, where 2 µL of AuNPs solution was dropped onto the working electrode and allowed to dry spontaneously. The number of AuNPs on each electrode was calculated from the datasheet (2.6 x 10¹⁰ particles/mL, O.D. ₅₂₀ =1.0), and all nanoparticles were assumed to have dried on the working electrode. To characterize the reduction current, the AuNPs on the electrode underwent a pre-oxidation process, followed by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) to evaluate the reduction current. The pre-oxidation condition was set at 1.2 V for 40 s, which was considered optimal for immunoassays. To evaluate the concentration response, 2 µL of the AuNPs solution was diluted with ultrapure water and poured and allowed to dry on the working electrode, pre-oxidized in 2 M KCl solution, and DPV measurements were performed. This experiment was also performed on an antibody-modified electrode, and the differences between the modified and unmodified electrodes were established. The same DPV measurements were performed using antibody-modified AuNPs (Ab-AuNPs). For immunoassay, IgA was reacted with a secondary antibody and incubated dropwise on an electrode. After washing, electrochemical measurements were performed [Results and Discussion] We investigated the influence of the DPV parameters and electrode surface conditions on a biosensor for the redox reaction of AuNPs. CV and classical theory were used to investigate the reduction kinetics of the AuNPs’ reduction after oxidation. The diffusion coefficient and electron transfer rate, which are related to sensor performance, were significantly reduced in the presence of antibodies and blocking agents on the electrode surface. This was due to the interaction between proteins and gold ions, and the effect of the electrode surface on sensitivity was evaluated using electrochemical reaction rates. Next, the influence of the biosensor on sensitivity was examined by focusing on the pulse amplitude of the DPV, and the increase in signal current coupled to increase in pulse amplitude was confirmed. The signal of AuNPs relative to the blank sample was of particular interest. Theoretically, changing the pulse potential above 100 mV does not change the current values obtained; however, in this study, a significant difference was observed between 150 mV and 100 mV. This was presumably due to the detection of nonspecific adsorption of antibodies that could not be detected under conventional conditions, suggesting the use of a more sensitive biosensor. This study provides evidence for fabrication of an IgA sensor with an improved Limit of detection (LOD) by optimizing pulse amplitude. Limits of detection (LOD) were obtained as 5.0 fmol/L (M) for AuNPs on a bare electrode, 0.1 pM for AuNPs on an antibody-modified electrodes, and 9.3 pM for AuNPs after immunoassay, allowing discussion of the given principle limits and actual biosensor performance (Figure). Under optimal conditions, the electrochemical biosensor achieved nearly two-fold signal amplification using a reduction current after AuNPs oxidation. These findings will allow the investigation of the kinetics of AuNPs on electrodes consisting of different materials to further elucidate the framework for improved sensitivity. Figure 1
Fully wireless electrochemiluminescent biosensor using a smartphone and wireless power supply Peer-reviewed

Eiichi Tamiya, Shuto Osaki, Hidenori Nagai

Biosensors 2023 33rd Anniversary World Congress on Biosensors　2023/06
Long-term monitoring of salivary anti-SARS-CoV-2 neutralizing IgG/sIgA antibodies using a portable electrochemical biosensor

Shuto Osaki, Eiichi Tamiya, Tomoko Tsuchihashi, Hiromi Ushijima, Keiichi Tsukinoki

Biosensors 2023 33rd Anniversary World Congress on Biosensors　2023/06
高感度イムノセンサ開発に向けた酸素プラズマ照射による電極表面改質

大﨑脩仁, Wilfred Espulgar, 齋藤真人, 民谷栄一

第83回分析化学討論会　2023/05
ワクチン接種前後の唾液中の抗SARS-CoV-2中和抗体（IgG/sIgA)と抗酸化活性をモニタリングする電気化学バイオセンサー

民谷栄一, 大﨑脩仁, 土橋朋子, 牛島ひろみ, 槻木恵一

電気化学第90回大会　2023/03
ワイヤレス給電を用いた電気化学発光センサー

民谷栄一, 大﨑脩仁

電気化学第90回大会　2023/03
酸素プラズマによる電気化学イムノセンサの高感度化

大﨑脩仁, Wilfred Espulger, 齋藤真人, 民谷栄一

電気化学第90回大会　2023/03
金ナノ粒子の電気化学活性を利用するバイオセンサの高感度化

大﨑脩仁, Wilfred Espulgar, 齋藤真人, 民谷栄一

第16回バイオ関連化学シンポジウム　2022/09
金ナノ粒子を用いる電気化学イムノセンサの感度特性評価

大﨑脩仁, Wilfred Espulger, 齋藤真人, 民谷栄一

2022電気化学秋季大会　2022/09
汗中硝酸イオンの検出を可能にするキャピラリー電気泳動用緩衝液の探索

木原巧貴, 渡邉紗裕美, 北村健一, 大﨑脩仁, 繁森弘基, 森内隆代, 脇田慎一

第20回産総研・産技連LS-BT合同研究発表会　2022/06
キャピラリー電気泳動法による採取汗試料の保存・前処理法の検討

木原巧貴, 木原巧貴, 渡邉紗裕美, 渡邉紗裕美, 北村健一, 北村健一, 大崎脩仁, 大崎脩仁, 繁森弘基, 繁森弘基, 森内隆代, 脇田慎一, 脇田慎一

分析化学討論会講演要旨集(Web)　82nd　2022
汗NO代謝物の測定に適したキャピラリー電気泳動法の開発

木原巧貴, 木原巧貴, 大崎脩仁, 大崎脩仁, 繁森弘基, 繁森弘基, 北村健一, 北村健一, 森内隆代, 脇田慎一

キャピラリー電気泳動シンポジウム講演要旨集　42nd　2022
NO代謝物の測定に適したキャピラリー電気泳動法の開発

木原巧貴, 木原巧貴, 大崎脩仁, 大崎脩仁, 繁森弘基, 繁森弘基, 北村健一, 北村健一, 森内隆代, 脇田慎一

日本分析化学会年会講演要旨集(Web)　71st　2022
ストレス計測評価用バイオセンシングデバイスの研究開発(9)唾液硝酸ISFET用新規膜材料の探索—R & D OF BIOSENSING DEVICES FOR STRESS MONITORING(9)STUDY ON NOVEL POLYMER MATRIX FOR SALIVARY NITRATE ISFETs

脇田慎一, 大﨑脩仁, 金時卓哉, 北村健一, 森内隆代

Proceedings of the Chemical Sensor Symposium　66　88-90　2019/09
Publisher: 電気化学会化学センサ研究会
イオン/バイオセンサによる唾液中ストレスマーカーの評価

大崎脩仁, 大崎脩仁, 荒木晃子, 金時卓哉, 金時卓哉, 脇田慎一, 脇田慎一, 民谷栄一, 民谷栄一

応用物理学会秋季学術講演会講演予稿集(CD-ROM)　80th　2019

ISSN： 2758-4704
ストレス計測評価用バイオセンシングデバイスの研究開発(8)唾液硝酸イオン計測によるストレス被験者実験の検討—R & D OF BIOSENSING DEVICES FOR STRESS MONITORING(8)STUDY ON EVALUATION FOR STRESS USING SALIVARY NITRATE MONITORING

脇田慎一, 北村健一, 村井康二, 大﨑脩仁, 金時卓哉, 森内隆代

Proceedings of the Chemical Sensor Symposium　64　1-3　2018/09
Publisher: 電気化学会化学センサ研究会
ストレス計測評価用バイオセンシングデバイスの研究開発(4)唾液硝酸イオン計測による緊張ストレス評価の検討—R & D OF BIOSENSING DEVICES FOR STRESS MONITORING(4)STUDY ON EVALUATION FOR ACUTE STRESS USING SALIVARY NITRATE MONITORING

脇田慎一, 北村健一, 村井康二, 大﨑脩仁, 金時卓哉, 森内隆代

Proceedings of the Chemical Sensor Symposium　63　49-51　2018/03
Publisher: 電気化学会化学センサ研究会
唾液硝酸ISFETs用ポリウレタン膜材料の探索研究

金時卓哉, 大崎脩仁, 森内隆代, 脇田慎一

日本分析化学会年会講演要旨集　67th　329-329　2018
Publisher: (公社)日本分析化学会
新規ポリウレタンを用いた唾液硝酸イオン計測用FETセンサ

大崎脩仁, 森内隆代, 脇田慎一

日本分析化学会年会講演要旨集　66th　281-281　2017
Publisher: (公社)日本分析化学会

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Presentations 18

イオントフォレシスを用いたリポソームの輸送効率評価

赤石大輔, 大﨑脩仁, 酒井郁佳, 鳥取聡一郎, 西澤松彦

2025年電気化学会東北支部第56回セミコンファレンス、第38回東北若手の会　2025/09/07
効率的な経皮投薬のためのポーラスマイクロニードルコーティング技術の開発

石川航太郎, 酒井郁佳, 鳥取聡一郎, 大﨑脩仁, 西澤松彦

2025年電気化学会東北支部第56回セミコンファレンス、第38回東北若手の会　2025/09/07
表面改質による高性能電気化学バイオセンサの開発 Invited

大﨑脩仁

みちのく分析化学シンポジウム　2025/07/19
バイオセンサ応用に向けた金ナノ粒子の電気化学特性解

第22回産総研・産技連 LS-BT合同研究発表会　2024/06/18
酸素プラズマを利用した印刷電極への抗体修飾と金ナノ粒子を利用した高感度電気化学バイオセンサへの応用

大﨑脩仁, 民谷栄一

第 20回産総研・産技連 LS-BT合同研究発表会　2022/06/28
キャピラリー電気泳動法による採取汗試料の保存・前処理法の検討

渡邉紗裕美, 北村健一, 大﨑脩仁, 繁森弘基, 森内隆代, 脇田慎一

第82回分析化学討論会　2022/05/14
IgAの日常的な on-site計測を可能とする電気化学イムノアッセイ法の評価

大﨑脩仁, 脇田慎一, 民谷栄一

電気化学会第 87回大会，名古屋工業大学　2020/03/18
An electrochemical immunoassay using gold-nanoparticle for on-site determination of the immune protein from plasma cells

Osaki, S, Wakida, S.I, Saito, M, Tamiya, E

Pacifichem 2021　2021/12/17
IgAの日常的な on-site計測を可能とする電気化学イムノアッセイ法の評価

大﨑脩仁, 脇田慎一, 民谷栄一, 脇田慎一, 民谷栄一

電気化学秋季大会　2021/09/08
Effect of the surfactants for gold-linked electrochemical immunoassay,

Osaki, S, Wakida, S.I, Tamiya, E

72nd Annual Meeting of International Society of Electrochemistry　2021/08/30
Gold-Linked Electrochemical immunoAssay based on screen-printed carbon electrode for sensitive and on-site detection of IgA.

Osaki, S, Wakida, S.I, Tamiya, E

31st Anniversary World Congress on Biosensors　2021/07/26
ポータブル型電気化学免疫センサを用いた唾液診断マーカーの計測

大﨑脩仁, 脇田慎一, 民谷栄一

第 19回産総研・産技連 LS-BT合同研究発表会　2021/05/27
On-site and Daily Stress-Measurement using Gold-Linked Electrochemical Immuno Assay for IgA determination

Osaki, S, Wakida, S.I, Saito, M, Tamiya, E

The Electrochemical Society 237th meeting　2020/05/10
Verification of a stability of polymer matrix for the salivary-nitrate-ISFET

Osaki, S, Kintoki, T, Moriuchi, T, Kitamura, K, Wakida, S.I

The Electrochemical Society 236th meeting　2019/10/15
イオン /バイオセンサによる唾液中ストレスマーカーの評価

大﨑脩仁, 荒木, 晃子, 金時, 卓哉, 脇田, 慎一, 民谷栄一

応用物理学会秋季学術講演会　2019/09/19
唾液ストレスマーカーを計測する化学／バイオセンサ

大﨑脩仁, 荒木, 晃子, 金時, 卓哉, 脇田, 慎一, 民谷栄一

電気化学秋季大会　2019/09/05
Drift study of ISFETs for salivary nitrate using novel polyurethane matrix membrane

2019/05/27
Influence of biocompatible polymer matrix on initial drift in saliva Invited

Osaki, S, Moriuchi, T, Kintoki, T, Wakida, S.I

1st International Symposium on Applied Physics and Bio-Medical Applications,　2018/11/17

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Research Projects 8

積層構造の厚さ・界面特性・材質変化を統合的に評価する非破壊検査基盤の創出

吉岡宰次郎

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2026/04/01 - 2029/03/31
金属ナノ粒子の粒径依存的なマルチプレックスバイオセンサ

大崎脩仁

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 若手研究

Institution: 東北大学

2026/04/01 - 2029/03/31
界面の緻密設計による長期安定型イオン選択性電界効果トランジスタ

大﨑脩仁、北村健一

Offer Organization: 公益社団法人日本分析化学会東北支部

System: 令和7年度公益社団法人日本分析化学会東北支部助成金

2025/08 - 2027/03
金属ナノ材料の表面エネルギー解析に基づく革新的バイオセンサ開発

大﨑脩仁

Offer Organization: 科学技術振興機構

Category: 戦略的な研究開発の推進/戦略的創造研究推進事業/ACT-X

2025 - 2027

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本研究では金属ナノ材料の酸化電位を表面エネルギーから予測するモデルを構築し、実験を介さずに電極特性を設計可能な理論を確立を行います。得られた理論を多様な金属ナノ材料に展開し、疾患ごとに必要な複数のバイオマーカーを電位差で選択的かつ同時に測定するマルチプレックスバイオセンサを開発します。感染症やがんなどの健康診断を網羅的かつ在宅ででき、個人差を克服する新バイオセンサ技術の創出を目指します。
バイオインターフェイス設計による高感度かつ前処理不要なPFASバイオセンシング技術の開発

大﨑脩仁寺田侑平青木寛

Offer Organization: 東北大学

System: 2025(令和7)年度東北大学－産総研マッチング研究支援事業

2025/05 - 2026/03
Comprehensive Electrochemical Profiling of Diverse Metal Nanomaterials for Advanced Biosensing Applications

Osaki Shuto

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Early-Career Scientists

2023/04 - 2025/03

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In this study, we systematically analyzed the relationship between the intrinsic electrochemical activity of various metal nanomaterials such as gold, silver, and platinum and their physicochemical characteristics. We clarified how parameters such as particle size, shape, and exposed crystal facets influence electrochemical responses, and applied these insights to the design of high-sensitivity biosensors. The findings contribute to the development of advanced electrochemical sensors for applications in medical diagnostics and environmental monitoring.
EIS and amperometric analysis of Gold Nanoparticle Probes on the Immunosensor surface

大﨑脩仁

Offer Organization: 公益社団法人電気化学会

System: 若手研究者の国際交流支援（第56回：2023年度前期)

2023/05 - 2023/06
唾液バイオマーカー計測デバイス開発とヘルスケア診断への応用

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for JSPS Fellows

Category: Grant-in-Aid for JSPS Fellows

2021/04 - 2023/03

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Teaching Experience 3

Mechanical and Aerospace Engineering Experiment I (Theme 3: Linear control)　Tohoku University
Mechanical and Aerospace Engineering Experiment Ⅱ(Fundamentals of Biosensing)　Tohoku University
Mechanical and Aerospace Engineering Experiment I (Theme 3: Linear control)　Tohoku University

Academic Activities 5

Analytical Sciences

2025/05 - 2025/07

Activity type: Peer review
Analytical Sciences

2024/07 - 2024/09

Activity type: Peer review
Workshop on Electrochemical Detection, De La Salle Univ. Manila, Philippines

2023/11/15 - 2023/11/15

Activity type: Other
IEEE SENSORS JOURNAL

2023/02/08 - 2023/02/15

Activity type: Peer review
Analytical Sciences

2022 - 2022

Activity type: Peer review