Details of the Researcher

PHOTO

Ikuho Kojima
Section
Graduate School of Dentistry
Job title
Associate Professor
Degree

  • D.D.S, Ph.D. (Tohoku University)

Profile

日本歯科放射線学会 認定医/専門医/指導医
日本口腔診断学会 認定医/指導医
日本核医学会 PET核医学認定歯科医

Board Certified Doctor/Specialist/Instructor, Japanese Society of Oral and Maxillofacial Radiology
Board Certified Doctor/Instructor, Japanese Society of Oral Diagnosis 
Board Certified Doctor in PET nuclear medicine, Japanese Society of Nuclear Medicine

Research History 5

  • 2024/10 - Present
    Tohoku University　Division of Dental Informatics and Radiology/Department of Oral and Maxillofacial Radiology　Associate Professor

  • 2024/08 - Present
    Tohoku University Hospital　Ciinical Artificial Intelligence center (AI Laboratory)　deputy drector

  • 2021/01 - 2024/09
    Tohoku University　Division of Oral and Maxillofacial Radiology (former Oral Diagnosis), Tohoku University Hospital　Associate Proffesor

  • 2009/04 - 2020/12
    Tohoku University　Graduate School of Dentistry　Assistant professor

  • 2006/04 - 2009/03
    Tohoku University　Faculty of Dentistry

Education 2

  • Tohoku University　Graduate School of Dentistry

    - 2006/03

  • Tohoku University　Faculty of Dentistry

    - 2002/03

Committee Memberships 4

  • The Japanease society of Oral Diagnosis/Oral Medicine　Board of Delegates

    2025/04 - Present

  • 日本歯科放射線学会　教育委員会 卒前教育担当・卒直後教育担当

    2024/05 - Present

  • Japanese Society of Oral and Maxilofacial Radiology　Board of Delegates

    2022/04 - Present

  • Japanease Society of Oral and Maxillofacial Radiology　Board of Committee on Radiation Protection

    2020/08 - Present

Professional Memberships 6

  • 日本歯科AI研究会

    - Present

  • Japanease Association for Medical Artificial Intelligence

    - Present

  • AAOMFR-Asian Academy of Oral and Maxillo-Facial Radiology

    - Present

  • JAPANESE SOCIETY OF NUCLEAR MEDICINE

    - Present

  • JAPANESE SOCIETY OF ORAL DIAGNOSIS/ORAL MEDICINE

    - Present

  • JAPANESE SOCIETY FOR ORAL AND MAXILLOFACIAL RADIOLOGY

    - Present

︎Show all ︎Show first 5

Research Interests 3

  • diagnostic Imaging

  • Oral and maxillofacial radiology

  • Oral Diagnosis

Research Areas 3

  • Life sciences / Tumor diagnostics and therapeutics /

  • Life sciences / Radiology /

  • Life sciences / Oral medicine (pathology) /

Awards 5

  1. Technologist Student Best Poster Presentation Award, 3rd prize

    2026/05　The 2026 Society of Nuclear Medicine and Molecular Imaging Annual meeting　Optimization of Quantitative Bone SPECT/CT Analysis for Jaw Lesions: Correction for Individual Variability

  2. 大会長賞

    2020/10　第33回日本口腔診断学会,第30回日本口腔内科学会,第13回日本口腔検査学会 合同学術大会　「半導体検出器を搭載した新PET装置による舌がん原発腫瘍の検出能および腫瘍サイズとの相関に関する検討」

  3. 優秀演題賞

    2018/10　日本核医学会第84回北日本地方会　「PET/CT画像におけるメタルアーチファクト除去処理を用いた減弱補正効果の検討」

  4. 第２回アクロメガリーフォーラム奨励賞

    2006/10　アクロメガリーフォーラム　末端肥大症様ラットモデルの作成および顎・口腔領域の変化−とくに顎骨と舌組織の変化の可逆性について—

  5. 日本歯科放射線学会学術奨励賞

    2006/05　日本歯科放射線学会　末端肥大症様ラットモデルにおける下顎骨形態変化の画像解析

Papers 76

  1. Image sharpening improves the visibility of reference points on low-dose lateral cephalometric radiographs: a phantom study

    Ikuho Kojima, Arata Ito, Yusuke Shimada, Naoko Tagaino Watanabe, Manami Ikawa, Shu Onodera, Hiroyasu Kanetaka, Masahiro Iikubo

    Dentomaxillofacial Radiology　2026/07/06

    DOI： 10.1093/dmfr/twag047 　

  2. Pediatric dental cone-beam computed tomography using half-acquisition and low-noise reconstruction: visual evaluation of clinical images

    Misaki Ito, Ikuho Kojima, Masahiro Iikubo, Shu Onodera, Masahiro Sai, Masaki Fujisawa, Toshiki Kato, Masaaki Nakamura, Masayuki Zuguchi, Koichi Chida

    Physical and Engineering Sciences in Medicine　2026/01/08

    DOI： 10.1007/s13246-025-01691-2 　

  3. An interpretable machine learning model using SHapley Additive exPlanations for preoperative cervical lymph node metastasis risk stratification in tongue squamous cell carcinoma: a multicenter study. International-journal

    Yang Li, Nengwen Huang, Li Wang, Haotian Xiao, Weiping Chen, Yifeng Xing, Takashi Nishioka, Kangwei Zhou, Ikuho Kojima, Jiang Chen, Yanjing Ou, Wen Li

    BMC oral health　2025/12/27

    DOI： 10.1186/s12903-025-07528-4 　

  4. Effect of dental metal prostheses and its metal artefacts on the incidence of nodular overcorrection on PET/CT images: a comparison between silicon photomultiplier and photomultiplier tube PET Peer-reviewed

    Ikuho Kojima, Kentaro Takanami, Naoko Watanabe, Hiroyasu Kodama, Hayato Odagiri, Masahiro Iikubo

    Dentomaxillofacial Radiology　2025/08/06

    DOI： 10.1093/dmfr/twaf058 　

  5. Locally advanced maxillary sinus cancer fed from the internal carotid artery Peer-reviewed

    Tatsuhiko Yamada, Masashi Kuroki, Hirofumi Shibata, Shoma Nagata, Hiroshi Kawada, Hiroki Kato, Akira Ohkoshi, Ikuho Kojima, Ryota Iinuma, Hiroshi Okuda, Yukio Katori, Masayuki Matsuo, Takenori Ogawa

    European Archives of Oto-Rhino-Laryngology　2025/03/28

    DOI： 10.1007/s00405-025-09343-7 　

  6. Evaluating fusion models for predicting occult lymph node metastasis in tongue squamous cell carcinoma. International-journal Peer-reviewed

    Wen Li, Yang Li, Li Wang, Minghuan Yang, Masahiro Iikubo, Nengwen Huang, Ikuho Kojima, Yingding Ye, Rui Zhao, Bowen Dong, Jiang Chen, Yiming Liu

    European radiology　2025/03/05

    DOI： 10.1007/s00330-025-11473-9 　

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    OBJECTIVES: This study evaluated and compared the effectiveness of various predictive models for forecasting occult lymph node metastasis (LNM) in tongue squamous cell carcinoma (TSCC) patients. METHODS: In this retrospective diagnostic experiment, 268 patients were recruited from three medical centers. Based on the different hospitals from which the patients were recruited, they were divided into a training set, an internal testing set, and two external testing sets, comprising 107, 53, 63, and 45 patients, respectively. Several predictive models were developed using patients' contrast-enhanced magnetic resonance imaging (CEMRI), including two-dimensional deep learning (2D DL), conventional radiomics (C-radiomics), and intratumoral heterogeneity radiomics (ITH-radiomics). Univariate and multivariate logistic regression analyses were conducted on the clinical data. Finally, two fusion strategies were used to construct the model. RESULTS: The ITH-radiomics model exhibited superior discriminative power compared to C-radiomics model. The late fusion model had the highest area under the curve (AUC) across all test sets (0.81-0.85). Compared to the late fusion model, the AUC values for the early fusion, 2D DL, C-radiomics, and ITH-radiomics models in the test sets ranged from 0.77 to 0.82, 0.64 to 0.81, 0.66 to 0.77, and 0.77 to 0.80, respectively. Additionally, the late fusion model demonstrated the highest accuracy (76-89%) and specificity (87-100%) across the test sets. CONCLUSIONS: The evaluation of the models' effectiveness revealed that the decision-based late fusion model, which integrated 2D DL, C-radiomics, ITH-radiomics, and clinical data, achieved the best results. This predictive approach can more accurately assess patients' conditions and aid in selecting surgical plans. KEY POINTS: Question How well does fusing multiple models work for predicting occult lymph node metastasis in patients with tongue squamous cell carcinoma? Findings The late fusion model, incorporating two-dimensional deep learning, conventional-radiomics, intratumoral heterogeneity-radiomics, and clinical features, achieved the best results compared to each individual model. Clinical relevance Patients with a high intratumoral heterogeneity-radiomics index exhibit an increased risk of occult lymph node metastasis in tongue squamous cell carcinoma patients, which showed that the late fusion model achieves superior predictive performance compared to the early fusion model.

  7. Maxillo-facial Radiographic Images of a Chronic Kidney Disease Patient with Calcification of Facial Arteries Peer-reviewed

    Shimada Yusuke, Kojima Ikuho, Iikubo Masahiro

    Shika Hoshasen　64　(2)　57-59　2025

    Publisher: Japanese Society for Oral and Maxillofacial Radiology

    DOI： 10.11242/dentalradiology.64.57 　

    ISSN： 0389-9705

    eISSN： 2185-6311

  8. Automated classification of pathological differentiation in head and neck squamous cell carcinoma using combined radiomics models from CET1WI and T2WI. International-journal Peer-reviewed

    Yang Li, Wen Li, Haotian Xiao, Weizhong Chen, Jie Lu, Nengwen Huang, Qingling Li, Kangwei Zhou, Ikuho Kojima, Yiming Liu, Yanjing Ou

    Clinical oral investigations　29　(1)　25-25　2024/12/21

    DOI： 10.1007/s00784-024-06110-6 　

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    OBJECTIVES: This study aims to develop an automated radiomics-based model to grade the pathological differentiation of head and neck squamous cell carcinoma (HNSCC) and to assess the influence of various magnetic resonance imaging (MRI) sequences on the model's performance. MATERIALS AND METHODS: We retrospectively analyzed MRI data from 256 patients across two medical centers, including both contrast-enhanced T1-weighted images (CET1WI) and T2-weighted images (T2WI). Regions of interest were delineated for radiomics feature extraction, followed by dimensionality reduction. An XGBoost classifier was then employed to build the predictive model, with its classification efficiency assessed using receiver operating characteristic curves and the area under the curve (AUC). RESULTS: In validation cohort, the AUC (macro/micro) values for models utilizing CET1WI, T2WI, and the combination of CET1WI and T2WI were 0.801/0.814, 0.741/0.798, and 0.885/0.895, respectively. The AUC for the three differentiations, ranging from well-differentiated to poorly differentiated, were 0.867, 0.909, and 0.837, respectively. The macro/micro precision, recall, and F1 scores of 0.688/0.736, 0.744/0.828, and 0.685/0.779 for the CET1WI + T2WI model. CONCLUSION: This study demonstrates that constructing a radiomics model based on CET1WI and T2WI sequences can be used to predict the pathological differentiation grading of HNSCC patients. CLINICAL RELEVANCE: This study suggests that a radiomics model integrating CET1WI and T2WI MRI sequences can effectively predict the pathological differentiation of HNSCC, providing an alternative diagnostic approach through non-invasive preoperative methods.

  9. CT scoring system for differentiating of sinonasal inverted papilloma and squamous cell carcinoma arising from inverted papilloma Peer-reviewed

    Miki Umeda, Masashi Kuroki, Hiroki Kato, Hirofumi Shibata, Nansei Yamada, Hiroshi Okuda, Kosuke Terazawa, Ryota Iinuma, Akira Ohkoshi, Shun Wakamori, Ikuho Kojima, Yukio Katori, Masayuki Matsuo, Takenori Ogawa

    European Archives of Oto-Rhino-Laryngology　282　(5)　2533-2538　2024/12/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s00405-024-09107-9 　

    ISSN： 0937-4477

    eISSN： 1434-4726

  10. Effects of Different Fields of View and Rotation Angles on Radiation Doses to Highly Radiosensitive Organs in Children Using Dental Cone Beam Computed Tomography Peer-reviewed

    Misaki Ito, Ikuho Kojima, Masahiro Iikubo, Shu Onodera, Masahiro Sai, Masaki Fujisawa, Toshiki Kato, Masaaki Nakamura, Masayuki Zuguchi, Koichi Chida

    Applied Sciences　2024/10/09

    DOI： 10.3390/app14199154 　

  11. Integrating lipid metabolite analysis with MRI-based transformer and radiomics for early and late stage prediction of oral squamous cell carcinoma Peer-reviewed

    Wen Li, Yang Li, Shiyu Gao, Nengwen Huang, Ikuho Kojima, Taro Kusama, Yanjing Ou, Masahiro Iikubo, Xuegang Niu

    BMC Cancer　24　(1)　2024/07/03

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s12885-024-12533-x 　

    eISSN： 1471-2407

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    Abstract Background Oral Squamous Cell Carcinoma (OSCC) presents significant diagnostic challenges in its early and late stages. This study aims to utilize preoperative MRI and biochemical indicators of OSCC patients to predict the stage of tumors. Methods This study involved 198 patients from two medical centers. A detailed analysis of contrast-enhanced T1-weighted (ceT1W) and T2-weighted (T2W) MRI were conducted, integrating these with biochemical indicators for a comprehensive evaluation. Initially, 42 clinical biochemical indicators were selected for consideration. Through univariate analysis and multivariate analysis, only those indicators with p-values less than 0.05 were retained for model development. To extract imaging features, machine learning algorithms in conjunction with Vision Transformer (ViT) techniques were utilized. These features were integrated with biochemical indicators for predictive modeling. The performance of model was evaluated using the Receiver Operating Characteristic (ROC) curve. Results After rigorously screening biochemical indicators, four key markers were selected for the model: cholesterol, triglyceride, very low-density lipoprotein cholesterol and chloride. The model, developed using radiomics and deep learning for feature extraction from ceT1W and T2W images, showed a lower Area Under the Curve (AUC) of 0.85 in the validation cohort when using these imaging modalities alone. However, integrating these biochemical indicators improved the model’s performance, increasing the validation cohort AUC to 0.87. Conclusion In this study, the performance of the model significantly improved following multimodal fusion, outperforming the single-modality approach. Clinical relevance statement This integration of radiomics, ViT models, and lipid metabolite analysis, presents a promising non-invasive technique for predicting the staging of OSCC.

  12. Temporomandibular joint ankylosis suspected to be associated with ankylosing spondylitis based on cervical computed tomography images: A pictorial essay Peer-reviewed

    Ikuho Kojima, Shinnosuke Nogami, Shin Hitachi, Yusuke Shimada, Yushi Ezoe, Yuka Yokoyama-Sato, Masahiro Iikubo

    Imaging Science in Dentistry　2024/05/07

    DOI： 10.5624/isd.20230243 　

  13. 口腔顎顔面領域における半導体検出器を搭載したPET/CTの定量性と有用性について

    小嶋 郁穂, 渡辺 尚子, 高浪 健太郎, 児玉 裕康, 小田桐 逸人, 飯久保 正弘

    核医学　61　(Suppl.)　S137-S137　2024

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  14. Erratum: Evaluation of radiation dose and image quality for dental cone-beam computed tomography in pediatric patients (2023J. Radiol. Prot.43 031518). International-journal

    Misaki Ito, Koichi Chida, Shu Onodera, Ikuho Kojima, Masahiro Iikubo, Toshiki Kato, Masaki Fujisawa, Masayuki Zuguchi

    Journal of radiological protection : official journal of the Society for Radiological Protection　43　(4)　2023/12/29

    DOI： 10.1088/1361-6498/ad1744 　

  15. Imaging findings of arrested pneumatisation and differentiation from other skull base lesions. International-journal Peer-reviewed

    Ikuho Kojima, Yusuke Shimada, Naoko Watanabe, Kentaro Takanami, Yohei Morishita, Akira Ohkoshi, Masahiro Iikubo

    Dento maxillo facial radiology　52　(8)　20230297-20230297　2023/11

    DOI： 10.1259/dmfr.20230297 　

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    OBJECTIVES: Arrested pneumatisation (AP) is an anatomic variant of the sphenoid sinus. Since AP remains underrecognised, otolaryngologists and radiologists may mistake AP for a lesion and perform follow-up imaging studies. We investigated the imaging findings of CT, MRI, and F-18 fludeoxyglucose (FDG)-positron emission tomography (PET) for AP, and discussed the differences between AP and other skull base lesions. METHODS: We reviewed multidetector low CT imaging of 442 patients (285 men and 157 women; age range, 19-93 years; mean age, 67.8 years) who underwent FDG-PET/CT for head and neck tumours between January 2019 and December 2019. The imaging findings of AP were reviewed on CT, MRI, FDG-PET/CT, and compared with those of fibrous dysplasia, chordoma, chondrosarcoma, multiple myeloma, and bone invasion of nasopharyngeal carcinoma. RESULTS: AP was identified in 22 patients (14 men and 8 women; age range, 24-93 years; mean age, 67.0 years) based on criteria from previous reports. AP manifested with well-circumscribed sclerotic margins on CT, without evidence of expansion. AP showed high-signal intensity on T1-/T2 weighted MRI. FDG-PET revealed non-significant uptake [maximum standardised uptake value (SUVmax): 0.85 (range, 0.4-1.27)] in AP. Contrastingly, skull base lesions showed expansion, poorly circumscribed boundaries without osteosclerotic margins, and moderate-to-severe FDG uptake (SUVmax: 1.8-8.4). CONCLUSIONS: The characteristic imaging findings of AP, namely non-expansile on CT and non-uptake on FDG-PET, may aid in its differentiation from other skull base lesions.

  16. Evaluation of radiation dose and image quality for dental cone-beam computed tomography in pediatric patients. International-journal Peer-reviewed

    Misaki Ito, Koichi Chida, Shu Onodera, Ikuho Kojima, Masahiro Iikubo, Toshiki Kato, Masaki Fujisawa, Masayuki Zuguchi

    Journal of radiological protection : official journal of the Society for Radiological Protection　2023/09/11

    DOI： 10.1088/1361-6498/acf868 　

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    Children are sensitive to radiation; therefore, it is necessary to reduce radiation dose as much as possible in pediatric patients. In addition, it is crucial to investigate the optimal imaging conditions as they considerably affect the radiation dose. In this study, we investigated the effect of different imaging conditions on image quality and optimized the imaging conditions for dental cone-beam computed tomography (CBCT) examinations to diagnose ectopic eruptions and impacted teeth in children. To achieve our aims, we evaluated radiation doses and subjective and objective image quality. The CBCT scans were performed using 3D Accuitomo F17. All combinations of a tube voltage (90 kV), tube currents (1, 2, 3 mA), fields of view (FOVs) (4×4, 6×6 cm), and rotation angles (360°, 180°) were used. Dose-area product (DAP) values were measured. SedentexCT IQ cylindrical phantom was used to physically evaluate the image quality. We used the modulation transfer function (MTF) as an index of resolution, the noise power spectrum (NPS) as an index of noise characteristics, and the system performance (SP) function as an overall evaluation index of the image. Five dentists visually evaluated the images from the head-neck phantom. The results showed that the image quality tended to worsen, and scores for visual evaluation decreased as tube currents, FOVs and rotation angles decreased. In particular, image noise negatively affected the delineation of the periodontal ligament space. The optimal imaging conditions were 90 kV, 2 mA, 4×4 cm FOV and 180° rotation. These results suggest that CBCT radiation doses can be significantly reduced by optimizing the imaging conditions.
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  17. Improvement of Imaging Conditions to Improve the Detection Rate of Head and Neck Cancer by Positron Emission Tomography/Computed Tomography Examination. Peer-reviewed

    Hayato Odagiri, Kentaro Takanami, Tomohiro Kaneta, Akihito Usui, Ikuho Kojima, Hiroyasu Kodama, Shin Saitou, Yoshitaka Tanaka, Yutaka Dendo, Kei Takase

    The Tohoku journal of experimental medicine　260　(2)　141-147　2023/05/30

    DOI： 10.1620/tjem.2023.J026 　

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    Positron emission tomography (PET)/computed tomography (CT) has improved sensitivity and resolution using silicon photomultiplier as a photosensor. Previously, only a fixed setting was available for the shooting time of 1 bed, but now, the shooting time can be changed for each bed. Time can be shortened or extended depending on the target area. A few studies reported on image reconstruction conditions for head and neck cancer in whole-body PET/CT examinations. Thus, this study aimed to optimize the imaging conditions of the head and neck region during whole-body imaging. A cylindrical acrylic container with a 200 mm diameter was used to simulate the head and neck area using a PET/CT system equipped with a semiconductor detector. Spheres of 6-30 mm in diameter were enclosed in the 200 mm diameter cylindrical acrylic vessel. Radioactivity in 18F solution (Hot:BG ratio 4:1) was enclosed in a phantom following the Japanese Society of Nuclear Medicine (JSNM) guidelines. Background radioactivity concentration was 2.53 kBq/mL. List mode acquisition of 1,800 s was collected at 60-1,800 s with the field of view of 700 mm and 350 mm. The image was reconstructed by resizing the matrix to 128 × 128, 192 × 192, 256 × 256, and 384 × 384, respectively. The imaging time per bed in the head and neck should be at least 180 s, and the reconstruction conditions should be a field of view (FOV) of 350 mm, matrix sizes of ≥ 192, and a Bayesian penalized likelihood (BPL) reconstruction with a β-value of 200. This allows detection of > 70% of the 8-mm spheres in the images.

  18. パノラマX線画像から中頭蓋窩左側部の病変を指摘できた線維性異形成症の一例 Peer-reviewed

    横山由加, 渡辺尚子, 小嶋郁穂, 嶋田雄介, 武田裕利, 千葉雅俊, 高橋 哲, 飯久保正弘

    歯科放射線　62　(2)　99-103　2023

    Publisher: (NPO)日本歯科放射線学会

    ISSN： 0389-9705

    eISSN： 2185-6311

  19. Root canal narrowing patterns of mandibular first premolars on panoramic radiographs according to the number of root canals diagnosed on cone beam computed tomographic images Peer-reviewed

    Yusuke Shimada, Ikuho Kojima, Takashi Nishioka, Maya Sakamoto, Masahiro Iikubo

    Odontology　111　(1)　172-177　2023/01

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s10266-022-00713-9 　

    ISSN： 1618-1247

    eISSN： 1618-1255

  20. High diagnostic accuracy for lymph node metastasis of oral squamous cell carcinoma using PET/CT with a silicon photomultiplier Peer-reviewed

    Kojima I, Takanami K, Ogawa T, Ishikawa K, Morishita Y, Ishii R, Ohkoshi A, Nakanome A, Odagiri H, Iikubo M

    Oral Radiology　38　(4)　540-549　2022/10

    DOI： 10.1007/s11282-022-00588-0 　

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    OBJECTIVE: The higher sensitivity of the new-generation positron emission tomography/computed tomography (PET/CT) with silicon photomultiplier (SiPM) may increase false-positive rates in detecting metastatic lymph nodes (LNs). This study aimed to clarify the usefulness of the SiPM PET scanner in diagnosing LN metastasis of oral squamous cell carcinoma (SCC). METHODS: We retrospectively reviewed consecutive F-18 fluorodeoxyglucose PET/CT images of 39 SCC patients using SiPM PET and 31 SCC patients using non-SiPM PET. We measured the maximum standardized uptake value (SUVmax) of the LNs on PET images and maximum short-axis diameter on transverse CT images. RESULTS: The sensitivity and specificity of SiPM PET were 86.2% and 95.6%, respectively (cut-off SUVmax, 4.6). The area under the curve (AUC) of SiPM PET (0.977; 95% confidence interval [CI], 0.958-0.995) was significantly higher than that of non-SiPM PET (0.825; 95% CI 0.717-0.934) (P < 0.01). In a size-limited analysis of diameter, the AUC of SiPM PET (≥ 0.96 for all diameters) was significantly higher than that of non-SiPM PET (tended to decrease as the LN diameter decreased) for the diagnosis of LN metastasis by SUVmax. CONCLUSION: SiPM PET had higher diagnostic accuracy for LN metastasis of oral SCC than non-SiPM PET, even for small LN metastasis without increasing false-positives.

  21. 鼻副鼻腔内反性乳頭腫及び乳頭腫内癌における画像診断 CTを用いたスコアリングによる鑑別 Peer-reviewed

    山田 南星, 黒木 将, 川口 真矢, 加藤 博基, 中目 亜矢子, 若盛 隼, 小嶋 郁穂, 小川 武則

    頭頸部癌　48　(2)　200-200　2022/05

    Publisher: (一社)日本頭頸部癌学会

    ISSN： 1349-5747

    eISSN： 1881-8382

  22. A comparative study on cephalometric differences in maxillofacial morphology between skeletal Class III cases with and without acromegaly: a pilot study. Peer-reviewed

    Atsushi Tanaka, Noriaki Shoji, Ikuho Kojima, Akira Kumasaka, Maya Sakamoto, Kiyo Sasaki, Tomohiro Fukunaga, Itaru Mizoguchi, Teiji Tominaga, Masahiro Iikubo

    Oral radiology　38　(2)　224-233　2022/04

    DOI： 10.1007/s11282-021-00548-0 　

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    OBJECTIVES: The most typical maxillofacial feature of patients with acromegaly is mandibular protrusion. This study aimed to determine differences in maxillofacial morphology between skeletal Class III patients with and without acromegaly using cephalometric analysis. METHODS: Cephalograms of 37 patients with acromegaly (Acro), 37 age-matched non-acromegalic patients with skeletal Class III malocclusion (C-III), and 37 age-matched Class I malocclusion patients (C-I; control) were retrospectively collected. The skeletal and dental morphology of each group was analyzed using cephalometric analysis, which included linear and angular measurements and facial profilograms. In addition, we analyzed diagnostic performance and cutoff values for discriminating acromegaly from skeletal Class III malocclusion using receiver operating characteristic (ROC) curve analysis. RESULTS: The mandibular ramus height was larger in the Acro group than in the other groups. The increase in L1/MP in the Acro group, which represented labial inclination of the mandibular central incisors, was the most characteristic feature in this study. ROC curve analysis indicated that a cutoff value of 88.4° for L1/MP had the highest diagnostic performance in discriminating acromegaly from non-acromegalic Class III malocclusion. CONCLUSIONS: Acromegaly was characterized by a greater degree of bimaxillary prognathism than was non-acromegalic Class III malocclusion. Focusing on labial inclination of the mandibular central incisors would be the most useful way to differentiate acromegaly from non-acromegalic Class III malocclusion.

  23. 歯科用CBCTにおける回転角度の違いが画質に及ぼす影響：物理評価による検討 Peer-reviewed

    伊藤 実咲, 小野寺 崇, 小嶋 郁穂, 千田 浩一

    日本医用画像情報誌　39　(2)　2022/02

  24. Radiographic images of the narrowing of dental pulp chambers in patients receiving long-term steroid therapy Peer-reviewed

    Naoko Watanabe, Yuka Yokoyama Sato, Ikuho Kojima, Yusuke Shimada, Yuriko Goto, Kuniyuki Izumita, Akira Kumasaka, Masahiro Iikubo

    Shikahousyasen　62　(1)　39-42　2022/01

    Publisher:

    ISSN： 0389-9705

    eISSN： 2185-6311

  25. Perfusion defects in non-enlarged metastatic lymph nodes using vessel wall magnetic resonance imaging: detection performance and diagnostic value Peer-reviewed

    Sakamoto M, Kojima I, Iikubo M, Ito K, Aoki T, Mori S, Ogawa T, Katori Y, Murata T, Ito D, Kodama T

    Clinical & Experimental Metastasis　2022/01

    DOI： 10.1007/s10585-022-10147-w 　

    ISSN： 0262-0898 1573-7276

  26. The accuracy of ultrasound and magnetic resonance imaging for estimating thickness of oral tongue squamous cell carcinoma and influence of biopsy on those findings Peer-reviewed

    Shinnosuke Nogami, Kensuke Yamauchi, Jun Kitamura, Hitoshi Miyashita, Ikuho Kojima, Atsumu Kouketsu, Toshi Furuuchi, Masahiro Iikubo, Hiroyuki Kumamoto, Tetsu Takahashi

    Oral Science International　19　(1)　24-30　2022/01

    DOI： 10.1002/osi2.1108 　

    ISSN： 1348-8643

  27. Comparative Study of Multiple High-Signal-Intensity Spots on 3D and 2D Magnetic Resonance Sialography for Patients with Sjögren’s Syndrome International-journal Peer-reviewed

    Yusuke Shimada, Ikuho Kojima, Masahiro Iikubo, André Luiz Ferreira Costa

    Radiology Research and Practice　2021　5846637-5846637　2021/12/26

    DOI： 10.1155/2021/5846637 　

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    We investigated the sensitivities of 2-dimensional (2D) magnetic resonance sialography (MR-S) and unilateral sagittal and axial 3-dimensional (3D) MR-S using a surface coil and their combination in diagnosing patients with Sjögren's syndrome (SS). We retrospectively analyzed the 3D and 2D MR-S results of 78 patients with SS. We evaluated the sensitivities of multiple high-signal-intensity spots and staging on MR sialograms and analyzed the efficient imaging methods and cross section for diagnosing patients with SS. The sensitivities of MR-S for detecting abnormal findings (i.e., MR-S stage 1 or higher) were as follows: 65 cases (83.3% [95% confidence interval (CI): 73.2-90.8]) for unilateral sagittal 3D MR-S; 62 cases (79.4% [95% CI: 68.8-87.8]) for axial 3D MR-S; 66 cases (84.6% [95% CI: 74.7-91.8]) for combined unilateral sagittal and axial 3D MR-S; and 32 cases (41.0% [95% CI: 30.0-52.7]) for bilateral sagittal 2D MR-S. The ratio of the abnormal finding of MR-S was tested using the two-tailed Fisher's exact test. Unilateral sagittal, axial, and combined unilateral sagittal and axial 3D MR-S showed significantly higher sensitivity than bilateral sagittal 2D MR-S, respectively (P < 0.001). Most cases upstaged by 3D MR-S were those positive (stage 1 or higher) among the stage 0 cases detected by 2D MR-S. Axial 3D MR-S, compared with 2D MR-S, understaged four cases, which was due to the imaging range of the axial 3D MR-S. We concluded that a single unilateral sagittal 3D MR-S was sufficient and axial 3D MR-S was unnecessary for SS staging. T1- and T2-weighted images are essential for investigating the salivary glands in patients with SS. Therefore, we also concluded that bilateral sagittal 3D MR-S of the parotid glands in addition to T1- and T2-weighted imaging is necessary, sufficient, and most efficient for precise MR imaging examination of the salivary glands, including diagnosing SS.

  28. Comparison of different diagnostic imaging techniques for the detection of bone invasion in oral cancers. International-journal Peer-reviewed

    Atsumu Kouketsu, Hitoshi Miyashita, Ikuho Kojima, Maya Sakamoto, Takaki Murata, Shiro Mori, Shinnnosuke Nogami, Kensuke Yamauchi, Hirokazu Nagai, Hiroyuki Kumamoto, Tetsu Takahashi

    Oral oncology　120　105453-105453　2021/07/12

    DOI： 10.1016/j.oraloncology.2021.105453 　

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    OBJECTIVES: To evaluate the ability of different imaging modalities to accurately detect bone invasion in oral squamous cell carcinomas. PATIENTS AND METHODS: Patients with oral squamous cell carcinoma, who were scheduled for mandibulectomy or maxillectomy, underwent clinical evaluation using five preoperative imaging diagnosis methods-contrast-enhanced MRI, CT, 99mTc scintigraphy (Tc scan), FDG-PET CT (PET/CT), and panoramic radiography. The sensitivity and specificity of each modality in detecting bone invasion were calculated by comparing the findings on the images with postoperative histopathological findings. In a subgroup of patients, we further assessed the ability of MRI and CT to detect the accurate extent of bone invasion, including the height, width, and depth in patients with pathological mandibular invasion. RESULTS: Overall, 50 patients were enrolled in this study, and nine patients with pathological mandibular invasion were included in our subgroup analysis. MRI was found to be the most useful method in detecting bone invasion, showing the highest sensitivity (88.9%) and negative predictive values (92.3%). CT (87.5% specificity and 77.8% sensitivity) was more specific than MRI, though less sensitive. Combined PET/CT was more sensitive (83.3%) and less specific (71.9%) than CT. Tc scan had high sensitivity (88.9%); however, the specificity was relatively low (71.9%). CONCLUSION: MRI was the most useful method in detecting bone invasion. A negative MRI result definitively excludes bone marrow invasion. In patients with positive MRI findings, a negative CT may be useful in ruling out bone marrow invasion.

  29. 半導体PET/CT装置の定量的評価による口腔癌の診断精度

    小嶋 郁穂

    核医学　58　(Suppl.)　S157-S157　2021

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  30. Clinical utility of apparent diffusion coefficient and diffusion-weighted magnetic resonance imaging for resectability assessment of head and neck tumors with skull base invasion International-journal Peer-reviewed

    Takenori Ogawa, Ikuho Kojima, Shun Wakamori, Takuya Yoshida, Takaki Murata, Maya Sakamoto, Akira Ohkoshi, Ayako Nakanome, Hidenori Endo, Toshiki Endo, Hajime Usubuchi, Yukio Katori

    Head and Neck　42　(10)　2896-2904　2020/10/01

    DOI： 10.1002/hed.26336 　

    ISSN： 1043-3074

    eISSN： 1097-0347

  31. Effect of exposure parameters and gutta-percha cone size on fracture-like artifacts in endodontically treated teeth on cone-beam computed tomography images Peer-reviewed

    Masahiro Iikubo, Toyohiro Kagawa, Junya Fujisawa, Akira Kumasaka, Takashi Nishioka, Ikuho Kojima, Maya Sakamoto, Kaoru Kobayashi, Kenji Yuasa

    Oral Radiology　36　(4)　344-348　2020/10/01

    DOI： 10.1007/s11282-019-00411-3 　

    ISSN： 0911-6028

    eISSN： 1613-9674

  32. High detection sensitivity and reliable morphological correlation of PET with a silicon photomultiplier for primary tongue squamous cell carcinoma Peer-reviewed

    Ikuho Kojima, Kentaro Takanami, Takenori Ogawa, Maya Sakamoto, Hirokazu Nagai, Hitoshi Miyashita, Masahiro Iikubo

    Annals of Nuclear Medicine　34　(9)　643-652　2020/09/01

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s12149-020-01489-0 　

    ISSN： 0914-7187

    eISSN： 1864-6433

  33. Florid Cemento-Osseous Dysplasia-Associated Simple Bone Cyst Showing Marked Irregular Border and High Apparent Diffusion Coefficient Value International-journal Peer-reviewed

    Ikuho Kojima, Takashi Nishioka, Maya Sakamoto, Yuko Sai, Yushi Ezoe, Masahiro Iikubo, Hiroyuki Kumamoto, Tetsu Takahashi

    Case Reports in Dentistry　2020　1-7　2020

    Publisher: Hindawi Limited

    DOI： 10.1155/2020/8854428 　

    ISSN： 2090-6447

    eISSN： 2090-6455

  34. 嚢胞成分を有する腫瘍との鑑別が困難であった耳下腺導管嚢胞の1例 Peer-reviewed

    西岡貴志, 小川武則, 村田 隆紀, 小嶋 郁穂, 飯久保正弘, 阪本真弥

    歯科放射線　60　(1)　24-26　2020

    Publisher: (NPO)日本歯科放射線学会

    ISSN： 0389-9705

    eISSN： 2185-6311

  35. 半導体検出器を搭載した新PET装置による口腔がんリンパ節転移の診断精度

    小嶋 郁穂, 高浪 健太郎, 小川 武則, 外山 由貴, 齊藤 美穂子, 阪本 真弥, 飯久保 正弘, 高橋 哲

    歯科放射線　59　(増刊)　49-49　2019/06

    Publisher: (NPO)日本歯科放射線学会

    ISSN： 0389-9705

    eISSN： 2185-6311

  36. Relationship of MR imaging of submandibular glands to hyposalivation in Sjögren's syndrome International-journal Peer-reviewed

    Ikuho Kojima, Maya Sakamoto, Masahiro Iikubo, Yusuke Shimada, Takashi Nishioka, Takashi Sasano

    Oral Diseases　25　(1)　117-125　2019/01

    DOI： 10.1111/odi.12941 　

    ISSN： 1354-523X

    eISSN： 1601-0825

  37. 歯冠切除マウスを用いた脳卒中後回復過程における咬合不全の影響

    Nakamura Kazuhiro, 小嶋 郁穂, 石川 達哉

    脳循環代謝　30　(1)　111-111　2018/10

    Publisher: (一社)日本脳循環代謝学会

    ISSN： 0915-9401

    eISSN： 2188-7519

  38. Clinical utility of dynamic-enhanced MRI in salivary gland tumors: retrospective study and literature review International-journal Peer-reviewed

    Takenori Ogawa, Ikuho Kojima, Ryo Ishii, Maya Sakamoto, Takaki Murata, Takahiro Suzuki, Kengo Kato, Ayako Nakanome, Akira Ohkoshi, Eiichi Ishida, Seiji Kakehata, Kiyoto Shiga, Yukio Katori

    European Archives of Oto-Rhino-Laryngology　275　(6)　1613-1621　2018/06/01

    DOI： 10.1007/s00405-018-4965-9 　

    ISSN： 0937-4477

    eISSN： 1434-4726

  39. 口腔癌多発転移との鑑別を要したメトトレキサート関連リンパ増殖性疾患(MTX-LPD)の1例

    阪本 真弥, 小嶋 郁穂, 飯久保 正弘, 笹野 高嗣, 宮下 仁, 纐纈 衆, 川井 忠, 高橋 哲, 村田 隆紀, 外山 由貴

    歯科放射線　58　(増刊)　46-46　2018/05

    Publisher: (NPO)日本歯科放射線学会

    ISSN： 0389-9705

    eISSN： 2185-6311

  40. 口腔癌頸部リンパ節転移の節外進展診断における3テスラblack-blood MR imaging法の有用性

    阪本 真弥, 小嶋 郁穂, 飯久保 正弘, 西岡 貴志, 笹野 高嗣, 伊藤 康一, 青木 孝文, 小川 武則, 森 士朗, 小玉 哲也

    歯科放射線　58　(増刊)　54-54　2018/05

    Publisher: (NPO)日本歯科放射線学会

    ISSN： 0389-9705

    eISSN： 2185-6311

  41. Treatment strategy for sinonasal malignant tumor with skull base invasion Peer-reviewed

    Takenori Ogawa, Ikuho Kojima, Takaki Murata, Maya Sakamoto, Keita Kishida, Noriyoshi Takahashi, Haruo Matsushita, Kazuya Arakawa, Kazuhiro Nomura, Ayako Nakanome, Akira Okoshi, Kenjiro Higashi, Ryo Ishii, Shun Sagai, Keiichi Jingu, Yukio Katori

    Japanese Journal of Head and Neck Cancer　27　(3)　379-385　2018/02

    Publisher: JAPAN SOCIETY FOR HEAD AND NECK SURGERY

    DOI： 10.5106/jjshns.27.379 　

    ISSN： 1349-581X

    eISSN： 1884-474X

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    We present six patients with head and neck osteosarcomas. They ranged in age from 15 to 84 years with a median age of 63.5 years. There were five males and one female. The site of origin was the mandibular bone in four patients, the maxilla in one, and the larynx in one. Five patients were TNM stage ⅡA and one was stage Ⅲ. Histological findings revealed osteoblastic cancers in five patients and chondroblastic in one. All patients underwent surgical resection and adjuvant therapy was performed in five cases. Pathologically complete resections were obtained in five cases; however, only one patient was diagnosed with positive margins in the surgical specimen. In two cases, the cancer recurred, one locally at 2 months and the other by distant metastasis at 12 months. The case of local recurrence was non-responsive to preoperative chemotherapy and was stump-positive upon resection.

  42. Takayasu arteritis coexisting with sclerosing osteomyelitis Peer-reviewed

    Tsuyoshi Shirai, Riiza Hanaoka, Yusuke Goto, Ikuho Kojima, Yusho Ishii, Yousuke Hoshi, Yoko Fujita, Yuko Shirota, Hiroshi Fujii, Tomonori Ishii, Hideo Harigae

    Internal Medicine　57　(13)　1929-1934　2018

    DOI： 10.2169/internalmedicine.0329-17 　

    ISSN： 0918-2918

    eISSN： 1349-7235

  43. MRI-based in vivo assessment of early cerebral infarction in a mouse filament perforation model of subarachnoid hemorrhage International-journal Peer-reviewed

    Kazumasu Sasaki, Tatsushi Mutoh, Kazuhiro Nakamura, Ikuho Kojima, Yasuyuki Taki, Jose Ignacio Suarez, Tatsuya Ishikawa

    Neuroscience Letters　653　(13)　173-176　2017/07/13

    DOI： 10.1016/j.neulet.2017.05.047 　

    ISSN： 0304-3940

    eISSN： 1872-7972

  44. 下顎骨骨炎が先行して発症した高安動脈炎の1例

    小嶋 郁穂, 阪本 真弥, 飯久保 正弘, 白井 剛志, 大田 英揮, 常陸 真, 村田 隆紀, 明石 敏昭, 笹野 高嗣

    歯科放射線　57　(増刊)　57-57　2017/05

    Publisher: (NPO)日本歯科放射線学会

    ISSN： 0389-9705

    eISSN： 2185-6311

  45. シェーグレン症候群における唾液腺MR imagingの診断精度 正診率83%の高空間分解能3D MR sialography

    小嶋 郁穂, 阪本 真弥, 飯久保 正弘, 熊本 裕行, 室井 梓, 菅原 由美子, 佐藤 しづ子, 笹野 高嗣

    日本口腔診断学会雑誌　30　(1)　105-105　2017/02

    Publisher: (一社)日本口腔診断学会

    ISSN： 0914-9694

    eISSN： 2188-2843

  46. Diagnostic performance of MR imaging of three major salivary glands for Sjögren's syndrome Peer-reviewed

    I. Kojima, M. Sakamoto, M. Iikubo, H. Kumamoto, A. Muroi, Y. Sugawara, S. Satoh-Kuriwada, T. Sasano

    Oral Diseases　23　(1)　84-90　2017/01/01

    DOI： 10.1111/odi.12577 　

    ISSN： 1354-523X

    eISSN： 1601-0825

  47. Treatment strategy for sinonasal malignant tumor with skull base invasion Peer-reviewed

    Takenori Ogawa, Ikuho Kojima, Takaki Murata, Maya Sakamoto, Keita Kishida, Noriyoshi Takahashi, Haruo Matsushita, Kazuya Arakawa, Kazuhiro Nomura, Ayako Nakanome, Akira Okoshi, Kenjiro Higashi, Ryo Ishii, Shun Sagai, Keiichi Jingu, Yukio Katori

    Japanese Journal of Head and Neck Cancer　43　(4)　409-414　2017

    Publisher: (一社)日本頭頸部癌学会

    DOI： 10.5981/jjhnc.43.409 　

    ISSN： 1349-5747

    eISSN： 1881-8382

  48. Influence of voxel size and scan field of view on fracture-like artifacts from gutta-percha obturated endodontically treated teeth on cone-beam computed tomography images International-journal Peer-reviewed

    Masahiro Iikubo, Takashi Nishioka, Shintaro Okura, Kaoru Kobayashi, Tsukasa Sano, Akitoshi Katsumata, Eiichiro Ariji, Ikuho Kojima, Maya Sakamoto, Takashi Sasano

    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology　122　(5)　631-637　2016/11/01

    DOI： 10.1016/j.oooo.2016.07.014 　

    ISSN： 2212-4403

    eISSN： 1528-395X

  49. 舌扁平上皮癌における原発巣の深さに関する臨床研究

    北村 淳, 野上 晋之介, 山内 健介, 纐纈 衆, 飯久保 正弘, 古内 壽, 小嶋 郁穂, 宮下 仁, 熊本 裕行, 高橋 哲

    日本口腔科学会雑誌　65　(2)　155-155　2016/07

    Publisher: (NPO)日本口腔科学会

    ISSN： 0029-0297

  50. 口腔癌の頸部リンパ節転移診断における3テスラblack-blood MR imagingの有用性について

    阪本 真弥, 小嶋 郁穂, 飯久保 正弘, 近藤 千裕, 伊藤 康一, 青木 孝文, 小川 武則, 森 士朗, 小玉 哲也, 笹野 高嗣

    歯科放射線　56　(増刊)　70-70　2016/06

    Publisher: (NPO)日本歯科放射線学会

    ISSN： 0389-9705

    eISSN： 2185-6311

  51. シェーグレン症候群の耳下腺、顎下腺、舌下腺のMRIに関する診断学的研究 MR信号強度不均一とMR sialography点状高信号域の診断精度について

    嶋田 雄介, 小嶋 郁穂, 阪本 真弥, 飯久保 正弘, 室井 梓, 菅原 由美子, 佐藤 しづ子, 笹野 高嗣

    日本口腔診断学会雑誌　29　(1)　39-39　2016/02

    Publisher: (一社)日本口腔診断学会

    ISSN： 0914-9694

    eISSN： 2188-2843

  52. MRIで悪性腫瘍箇所を同定し得た耳下腺多型腺腫由来癌の１例 Peer-reviewed

    若盛 隼, 小川 武則, 臼渕 肇, 阪本 真弥, 小嶋 郁穂, 村田 隆紀, 嵯峨井 俊, 中目 亜矢子, 大越 明, 東 賢二郎, 石井 亮, 白倉 真之, 石川 智彦, 香取 幸夫

    頭頸部外科　26　(3)　389-393　2016

    Publisher: JAPAN SOCIETY FOR HEAD AND NECK SURGERY

    DOI： 10.5106/jjshns.26.389 　

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    We present a patient with a malignant lesion diagnosed as carcinoma ex pleomorphic adenoma of the parotid gland detected by advanced MRI techniques such as diffusion-weighted MR imaging （DWI） and apparent diffusion coefficient （ADC）. A 64-year-old male was referred to our hospital due to a gradual growing left parotid tumor originally discovered 20 years earlier. MRI imaging detected a left parotid tumor 4 cm in the longer axis and 3 cm in the shorter axis. On two occasions, fine needle aspiration cytology and an echo-guided core needle biopsy indicated the possibility of a carcinoma. Total parotidectomy with facial nerve reconstruction was performed. Histological findings confirmed the presence of a carcinoma as well as hyaline degeneration. The tumor was finally diagnosed as a carcinoma ex pleomorphic adenoma by histological examination and gradual growth of the tumor. Advanced MRI techniques revealed low ADC and high DWI only in the regions of the carcinoma.

  53. Insulin-Like Growth Factor I Inhibits Alveolar Bone Loss Following Tooth Extraction in Rats International-journal Peer-reviewed

    Akira Kumasaka, Masahiro Iikubo, Takashi Nishioka, Ikuho Kojima, Noriaki Shoji, Maya Sakamoto, Takashi Sasano

    Clinical Implant Dentistry and Related Research　17　(6)　1174-1179　2015/12/01

    DOI： 10.1111/cid.12227 　

    ISSN： 1523-0899

    eISSN： 1708-8208

  54. Root canal filling materials spread pattern mimicking root fractures in dental CBCT images International-journal Peer-reviewed

    Masahiro Iikubo, Takashi Osano, Tsukasa Sano, Akitoshi Katsumata, Eiichiro Ariji, Kaoru Kobayashi, Takashi Sasano, Mamoru Wakoh, Kenji Seki, Ikuho Kojima, Maya Sakamoto

    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology　120　(4)　521-527　2015/10/01

    DOI： 10.1016/j.oooo.2015.06.030 　

    ISSN： 2212-4403

    eISSN： 1528-395X

  55. Comparison of bisecting and parallel intraoral radiography and cone-beam computed tomography for detecting various horizontal angle root fractures Peer-reviewed

    Masahiro Iikubo, Takashi Kamio, Naoya Hashimoto, Takashi Nishioka, Mamoru Wakoh, Tsukasa Sano, Chinami Igarashi, Kaoru Kobayashi, Kenji Seki, Akitoshi Katsumata, Eiichiro Ariji, Takashi Sasano, Maya Sakamoto, Ikuho Kojima

    Oral Radiology　31　(3)　173-180　2015/09/05

    DOI： 10.1007/s11282-015-0201-0 　

    ISSN： 0911-6028

    eISSN： 1613-9674

  56. 水平的歯根破折に関する画像診断学的研究 角度の異なる歯根破折線の検出能に関する二等分法、平行法および歯科用CTの比較

    佐々城 真, 飯久保 正弘, 橋本 直也, 嶋田 雄介, 小嶋 郁穂, 阪本 真弥, 笹野 高嗣

    日本口腔診断学会雑誌　28　(1)　65-65　2015/02

    Publisher: (一社)日本口腔診断学会

    ISSN： 0914-9694

    eISSN： 2188-2843

  57. Diagnostic value of capsule-like rim enhancement on magnetic resonance imaging for distinguishing malignant from benign parotid tumours Peer-reviewed

    M. Sakamoto, M. Iikubo, Ikuho Kojima, T. Sasano, S. Mugikura, T. Murata, M. Watanabe, K. Shiga, T. Ogawa, S. Takahashi

    International Journal of Oral and Maxillofacial Surgery　43　(9)　1035-1041　2014/09

    DOI： 10.1016/j.ijom.2014.03.008 　

    ISSN： 0901-5027

    eISSN： 1399-0020

  58. シェーグレン症候群患者の唾液腺MR-sialographyにおける点状高信号域の検出能 3D法と2D法の比較検討

    小嶋 郁穂, 阪本 真弥, 飯久保 正弘, 酒井 梓, 菅原 由美子, 佐藤 しづ子, 笹野 高嗣

    日本口腔診断学会雑誌　27　(1)　95-95　2014/02

    Publisher: (一社)日本口腔診断学会

    ISSN： 0914-9694

    eISSN： 2188-2843

  59. 東北大学病院歯科部門における外来患者の動向 －臨床研修ならびに臨床教育に対する意識調査－ Peer-reviewed

    酒井 梓, 飯久保正弘, 嶋田雄介, 橋本直也, 熊坂 晃, 佐々城 真, 遠藤 雄, 小嶋郁穂, 庄司憲明, 笹野高嗣

    日本口腔診断学学会雑誌　27　(1)　7-12　2014/02

    Publisher: The Japanese Society of Oral Diagnosis / Oral Medicine

    DOI： 10.15214/jsodom.27.7 　

    ISSN： 0914-9694

    More details Close

    This study was carried out to collect and analyze the data obtained from patients to establish the ideal education system for clinical training at university dental hospitals.<br>For this purpose, we obtained the information from the outpatients who visited the Tohoku University Dental Hospital using a questionnaire for our education and clinical training system.<br>The following results were obtained.<br>(1) "Referral from general practitioner" was the most common reason for visiting our hospital for new patients and patients aged younger than 40, while "reliable treatment" was the most common reason for revisiting patients and patients aged over 40.<br>(2) Most patients accepted the treatment and observation by interns and undergraduate students regardless of generation. Revisiting patients refused to see them less than new patients.<br>(3) The permissible time for clinical training purposes was longer in revisiting patients and patients aged over 50 compared with new patients and patients aged younger than 50, respectively.<br>These results suggested that elderly and revisiting patients were more cooperative with our clinical training program than younger and newer patients through the assurance of extensive safety and conscientiousness regarding treatment.

  60. 【基本臨床画像診断 読影の基本を知り各種疾患をよむ】(Part_01)正常像を理解する 口内法X線写真

    小嶋 郁穂, 阪本 真弥, 笹野 高嗣

    補綴臨床　別冊　(基本臨床画像診断)　6-11　2013/12

    Publisher: 医歯薬出版(株)

    ISSN： 0018-6341

  61. 東北大学病院におけるインプラント術前ＣＴ検査の臨床統計学的検討 Peer-reviewed

    古内 壽, 小嶋郁穂, 酒井梓, 佐藤恭子, 佐藤しづ子, 菅原由美子, 飯久保正弘, 庄司憲明, 阪本真弥, 笹野高嗣

    東北大学歯学雑誌　31　(1)　8-15　2012/06

    Publisher:

    ISSN： 0287-3915

  62. Difficulty of the differential diagnosis of basal cell adenoma and basal cell adenocarcinoma of parotid gland by magnetic resonance imaging: Case reports and literature review Peer-reviewed

    Ikuho Kojima, Maya Sakamoto, Mika Watanabe, Shoki Takahashi, Shunji Mugikura, Kiyoto Shiga, Masahiro Iikubo, Munemasa John Yamamura, Takashi Sasano

    Oral Radiology　28　(1)　24-31　2012/03

    DOI： 10.1007/s11282-011-0076-7 　

    ISSN： 0911-6028

    eISSN： 1613-9674

  63. Morphological and histopathological changes in orofacial structures of experimentally developed acromegaly-like rats: An overview International-journal Peer-reviewed

    Masahiro Iikubo, Ikuho Kojima, Maya Sakamoto, Akane Kobayashi, Hidetoshi Ikeda, Takashi Sasano

    International Journal of Endocrinology　2012　254367-254367　2012

    DOI： 10.1155/2012/254367 　

    ISSN： 1687-8337

    eISSN： 1687-8345

  64. 歯科受診患者の主訴に関する診断学的研究 過去30年間の主訴の変遷と社会的背景について Peer-reviewed

    小嶋郁穂, 飯久保正弘, 金田直人, 阪本真弥, 佐々城真, 熊坂晃, 鈴木宏尚, 伊藤あゆみ, 山村宗正, 佐藤恭子, 酒井梓, 佐藤しづ子, 菅原由美子, 古内壽, 庄司憲明, 笹野高嗣

    日本口腔診断学会雑誌　24　(3)　320-325　2011/10

    ISSN： 0914-9694

  65. 咬筋における痛みと浮腫性変化に関する研究

    飯久保正弘, 山村宗正, 李麗, 森 士朗, 小嶋郁穂, 佐藤しづ子, 庄司憲明, 阪本真弥, 笹野高嗣

    日本機会学会2010年次大会講演論文集　6　165-166　2010/09

    Publisher: The Japan Society of Mechanical Engineers

    DOI： 10.1299/jsmemecjo.2010.6.0_165 　

    More details Close

    To clarify the relationship between masseter muscle pain and its edematous changes, we investigated whether increased in thickness and plasma extravasation may occur in the rat masseter muscle as a result of capsaicin injection. In anaesthetized rat, capsaicin solution was injected into a masseter muscle on the one side, and vehicle into one on the other side. The thickness of the masseter muscle was measured by means of high-frequency ultrasound. Plasma extravasation was determined by means of the Evans blue dye method. As results, capsaicin injection into the masseter muscle induced thickening and plasma extravasation in the masseter muscle, and combination with local anaestesia counteracted the dye extravasation, indicating neurogenic inflammation change in rat masseter muscle.

  66. Excessive lateral dental arch expansion in experimentally developed acromegaly-like rats International-journal Peer-reviewed

    Masahiro Iikubo, Akane Kobayashi, Ikuho Kojima, Hidetoshi Ikeda, Maya Sakamoto, Takashi Sasano

    Archives of Oral Biology　53　(10)　924-927　2008/10

    DOI： 10.1016/j.archoralbio.2008.04.007 　

    ISSN： 0003-9969

    eISSN： 1879-1506

  67. High serum levels of IGF-I contribute to promotion of endochondral ossification in mandibular condyle and cause its specific elongation in acromegaly-like rats Peer-reviewed

    I. Kojima, M. Likubo, A. Kobayashi, H. Ikeda, M. Sakamoto, T. Sasano

    Hormone and Metabolic Research　40　(8)　533-538　2008/08

    DOI： 10.1055/s-2008-1076697 　

    ISSN： 0018-5043

  68. 咀嚼筋の運動障害を引き起こした三叉神経鞘腫の2症例

    飯久保 正弘, 古内 寿, 阪本 真弥, 小嶋 郁穂, 笹野 高嗣

    歯科放射線　47　(1-4)　119-119　2008/03

    Publisher: (NPO)日本歯科放射線学会

    ISSN： 0389-9705

    eISSN： 2185-6311

  69. A case of masticatory disturbance incidental to trigeminal schwannoma: changes in occlusal force and masticatory sensation before and after radiosurgery. Peer-reviewed

    M. Iikubo, M. Sakamoto, T. Furuuchi, M. Fujimura, T. Tominaga, S. Takahashi, I. Kojima, T. Sasano

    The British journal of radiology　81　(963)　e84-7　2008/03

    DOI： 10.1259/bjr/43860468 　

    eISSN： 1748-880X

  70. 頸部リンパ節に多発した胚中心進展性異形成の一例 Peer-reviewed

    飯久保正弘, 古内寿, 阪本真弥, 菅原由美子, 西岡貴志, 小嶋郁穂, 示野陽一, 庄司憲明, 笹野高嗣

    歯科放射線　47　(1月4日)　26-32　2008/03

    DOI： 10.11242/dentalradiology.47.26 　

    ISSN： 0389-9705

  71. 本学歯学部附属病院における新来患者の動向(第3報) 診療および教育に対する意識調査 Peer-reviewed

    栗原直之, 阪本真弥, 小嶋郁穂, 示野陽一, 大場麻美, 小野寺大, 菅原由美子, 佐藤しづ子, 古内壽, 飯久保正弘, 庄司憲明, 駒井伸也, 笹野高嗣

    東北大学歯学雑誌　25　(2)　78-84　2006/12

    ISSN： 0287-3915

  72. Morphological and histopathological changes in tongues of experimentally developed acromegaly-like rats Peer-reviewed

    Akane Kobayashi, M. Iikubo, I. Kojima, H. Ikeda, M. Sakamoto, T. Sasano

    Hormone and Metabolic Research　38　(3)　146-151　2006/03

    DOI： 10.1055/s-2006-925176 　

    ISSN： 0018-5043

  73. 末端肥大症様ラットモデルにおける下顎骨形態変化の画像解析 Peer-reviewed

    小嶋郁穂, 飯久保正弘, 小林あかね, 阪本真弥, 笹野高嗣

    歯科放射線　45　(3)　105-109　2005/09

    Publisher: Japanese Society for Oral and Maxillofacial Radiology

    DOI： 10.11242/dentalradiology1960.45.105 　

    ISSN： 0389-9705

    More details Close

    Purpose: To investigate morphological changes in the mandible using the recently developed acromegaly-like rat model, induced by exogenous administration of insulin-like growth factor I (IGF-I), and to clarify whether the changes are reversible after normalization of the circulating IGF-I level.<br>Material and methods: Human recombinant IGF-I (SOMAZON, Astellas Pharma Inc., Tokyo, Japan) (640μg/day) was subcutaneous infused continuously to 10-week-old male rats for 4 weeks (IGF-I group) (n=6). The control sham-operated animals were injected with saline alone (control group) (n=6). Rats were sacrificed immediately on ending administration (age 14 weeks). Another 12 rats (6 from each group) were housed for an additional 4 weeks after administration ended. Measurement of body weight and blood sampling were done before sacrificing rats (at age 14 and 18 weeks). Then, IGF-I serum level was measured from the sera. After sacrificing the rats, their mandibles were excised. Morphological analysis on the mandible was performed on lateral cephalometric image using soft X-ray equipment (SOFTEX Type CMB, SOFTEX Corp., Tokyo, Japan).<br>Results: Body weights, as well as total IGF-I (human+rat) serum level was markedly higher in the IGF-I group during administration of IGF-I, with a return to the control level after IGF-I administration ceased. Some linear mesurements of the mandible, i. e., Mental foramen (MeF) -Condyle (Cd), MeF-Infradentale (Id), Mandibular foramen (MaF)-Cd, MaF-Id, Cd-Id and Cd-Deepest point of the antegonial notch, significantly increased in the IGF-I group as compared with the control group both during and after IGF-I administration (age 14 and 18 weeks).<br>Conclusion: In our acromegaly-like rat model, specific enlargement of the mandible was found in the length of the condylar process and mandibular body. Such morphological changes were not reversible after normalization of the circulating IGF-I level.

  74. 末端肥大症ラットモデルにおける顎・口腔領域の動的変化に関する研究(第2報) 下顎骨の形態学的変化について

    小嶋 郁穂, 飯久保 正弘, 小林 あかね, 橋本 憲二, 阪本 真弥, 笹野 高嗣

    日本口腔診断学会雑誌　17　(2)　296-296　2004/10

    Publisher: (一社)日本口腔診断学会

    ISSN： 0914-9694

    eISSN： 2188-2843

  75. Insulin-like growth factor-I stimulates acromegaly-like specific mandibular enlargement in rats Peer-reviewed

    M. Iikubo, H. Ikeda, A. Kobayashi, I. Kojima, K. Hashimoto, M. Sakamoto, T. Sasano

    Hormone and Metabolic Research　36　(10)　696-701　2004/10

    DOI： 10.1055/s-2004-826019 　

    ISSN： 0018-5043

  76. Intracellular and extracellular pHs of Streptococcus mutans after addition of acids: Loading and efflux of a fluorescent pH indicator in streptococcal cells Peer-reviewed

    Y. Iwami, K. Kawarada, I. Kojima, H. Miyasawa, H. Kakuta, H. Mayanagi, N. Takahashi

    Oral Microbiology and Immunology　17　(4)　239-244　2002

    DOI： 10.1034/j.1399-302X.2002.170406.x 　

    ISSN： 0902-0055

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Misc. 21

  1. 口腔顎顔面領域における半導体検出器を搭載したPET/CTの定量性:臨床的有用性と課題

    小嶋郁穂

    映像情報メディカル　Vol.57　(No.11)　2025/10

  2. A Study on overcorrection of PET/CT images in the oral cavity: relationship with standardized uptake value and dental metal prostheses

    小嶋郁穂, 小嶋郁穂, 高浪健太郎, 渡辺尚子, 渡辺尚子, 児玉裕康, 小田桐逸人, 飯久保正弘, 飯久保正弘

    歯科放射線　64　2024

    ISSN： 0389-9705

  3. The Effect of Dental Metal Artifacts on PET/CT Quantification: Phantom Experiments for Metal artifact reduction in attenuation correction

    渡辺尚子, 渡辺尚子, 小嶋郁穂, 小嶋郁穂, 児玉裕康, 小田桐逸人, 高浪健太郎, 飯久保正弘, 飯久保正弘

    歯科放射線　64　2024

    ISSN： 0389-9705

  4. 口腔顎顔面領域における半導体検出器を搭載したPET/CTの定量性と有用性について

    小嶋郁穂, 渡辺尚子, 高浪健太郎, 児玉裕康, 小田桐逸人, 飯久保正弘

    核医学(Web)　61　(Supplement)　2024

    ISSN： 2189-9932

  5. CT imaging evaluation of phantoms for visualization and quantification of intraosseous contrast agents

    小嶋郁穂, 嶋田雄介, 飯久保正弘, 都木利之, 小池昭史, 青木徹, 森井久史

    生体医歯工学共同研究拠点成果報告書　2022　2023

  6. 手術に必要な画像診断―口腔・咽頭編 下歯肉・下顎腫瘍切除術

    石田英一, 小川武則, 小嶋郁穂, 大越明, 石井亮, 川村善宜, 石川智彦, 橋本光, 香取幸夫

    JOHNS　34　(5)　583‐587-587　2018/05/01

    Publisher: (株)東京医学社

    ISSN： 0910-6820

  7. MRIが診断に有用であった頭頸部悪性腫瘍の2症例

    中目亜矢子, 小川武則, 小嶋郁穂, 阪本真弥, 村田隆紀, 臼渕肇, 石井亮, 川村善宜, 大越明, 嵯峨井俊, 香取幸夫

    JOHNS　34　(1)　132‐137-137　2018/01/01

    Publisher: (株)東京医学社

    ISSN： 0910-6820

  8. 3テスラblack‐blood MR imagingが口腔癌患者の頸部リンパ節転移診断に有用であった2症例

    小嶋郁穂, 阪本真弥, 飯久保正弘, 小川武則, 渡邉みか, 大田英揮, 村田隆紀, 森士朗, 小玉哲也, 笹野高嗣

    歯科放射線　56　51　2016/06/08

    ISSN： 0389-9705

  9. IGF-Iは抜歯後のラット歯槽骨吸収を抑制する

    熊坂 晃, 飯久保 正弘, 西岡貴志, 小嶋 郁穂, 庄司 憲明, 阪本 真弥, 笹野 高嗣

    歯科放射線　56　(増刊)　50-50　2016/06

    Publisher: (NPO)日本歯科放射線学会

    ISSN： 0389-9705

    eISSN： 2185-6311

  10. 東北大学病院歯科部門における卒前臨床実習および卒後臨床研修に対する外来患者の意識調査

    室井 梓, 酒井, 飯久保 正弘, 嶋田 雄介, 橋本 直也, 熊坂 晃, 佐々城 真, 小嶋 郁穂, 庄司 憲明, 笹野 高嗣

    日本口腔診断学会雑誌　29　(1)　40-41　2016/02

    Publisher: (一社)日本口腔診断学会

    ISSN： 0914-9694

  11. CT画像にみられる根管充填剤による歯根破折様アーチファクトについて

    飯久保正弘, 嶋田雄介, 佐々城真, 熊坂晃, 小嶋郁穂, 阪本真弥, 笹野高嗣

    日本口腔診断学会雑誌　29　(1)　2016

    ISSN： 0914-9694

  12. 舌扁平上皮癌における原発巣の深さに関する臨床研究

    北村淳, 野上晋之介, 山内健介, 纐纈衆, 纐纈衆, 飯久保正弘, 古内壽, 小嶋郁穂, 宮下仁, 熊本裕行, 高橋哲

    日本口腔科学会学術集会プログラム・抄録集　70th　202　2016

  13. IGF-Iは抜歯後のラット歯槽骨吸収を抑制する

    熊坂 晃, 飯久保 正弘, 小嶋 郁穂, 庄司 憲明, 阪本 真弥, 笹野 高嗣

    日本口腔診断学会雑誌　28　(1)　63-63　2015/02

    Publisher: (一社)日本口腔診断学会

    ISSN： 0914-9694

    eISSN： 2188-2843

  14. IGF-Iは抜歯後のラット歯槽骨吸収を抑制する

    熊坂 晃, 飯久保 正弘, 小嶋 郁穂, 庄司 憲明, 阪本 真弥, 笹野 高嗣

    日本口腔内科学会雑誌　20　(2)　72-72　2014/12

    Publisher: (一社)日本口腔内科学会

    ISSN： 2186-6147

    eISSN： 2186-6155

  15. Morphological and histopathological changes in orofacial structures of experimentally developed acromegaly-like rats: An overview

    Masahiro Iikubo, Ikuho Kojima, Maya Sakamoto, Akane Kobayashi, Hidetoshi Ikeda, Takashi Sasano

    International Journal of Endocrinology　2012　254367-254367　2012

    DOI： 10.1155/2012/254367 　

    ISSN： 1687-8337

    eISSN： 1687-8345

  16. 咬筋における痛みと浮腫性変化に関する研究 痛み刺激による血漿漏出について

    飯久保 正弘, 山村 宗正, 小嶋 郁穂, 佐藤 しづ子, 庄司 憲明, 阪本 真弥, 笹野 高詞

    日本口腔診断学会雑誌　23　(2)　378-378　2010/10

    Publisher: (一社)日本口腔診断学会

    ISSN： 0914-9694

    eISSN： 2188-2843

  17. 東北大学病院における問診票導入による医療面接時間の短縮効果について

    庄司 憲明, 金田 直人, 飯久保 正弘, 山村 宗正, 伊藤 あゆみ, 佐藤 恭子, 酒井 梓, 小嶋 郁穂, 菅原 由美子, 佐藤 しづ子, 古内 壽, 阪本 真弥, 笹野 高嗣

    日本口腔診断学会雑誌　23　(2)　381-381　2010/10

    Publisher: (一社)日本口腔診断学会

    ISSN： 0914-9694

    eISSN： 2188-2843

  18. 東北大学病院附属歯科医療センターにおける新来患者の主訴に関する疫学調査

    小嶋 郁穂, 飯久保 正弘, 金田 直人, 阪本 真弥, 佐々城 真, 熊坂 晃, 鈴木 宏尚, 伊藤 あゆみ, 山村 宗正, 佐藤 恭子, 酒井 梓, 佐藤 しづ子, 菅原 由美子, 古内 壽, 庄司 憲明, 笹野 高嗣

    日本口腔診断学会雑誌　23　(2)　382-382　2010/10

    Publisher: (一社)日本口腔診断学会

    ISSN： 0914-9694

  19. 東北大学病院附属歯科医療センターにおける新来患者の主訴に関する疫学調査

    小嶋郁穂, 飯久保正弘, 金田直人, 阪本真弥, 佐々城真, 熊坂晃, 鈴木宏尚, 伊藤あゆみ, 山村宗正, 佐藤恭子, 酒井梓, 佐藤しづ子, 菅原由美子, 古内壽, 庄司憲明, 笹野高嗣

    日本口腔診断学会総会プログラム・抄録集　23rd　48　2010

  20. 東北大学病院における問診票導入による医療面接時間の短縮効果について

    庄司憲明, 金田直人, 飯久保正弘, 山村宗正, 伊藤あゆみ, 佐藤恭子, 酒井梓, 小嶋郁穂, 菅原由美子, 佐藤しづ子, 古内壽, 阪本真弥, 笹野高嗣

    日本口腔診断学会総会プログラム・抄録集　23rd　46　2010

  21. 学部及び病院における口腔診断科の役割について 村井構想「歯科放射線学をベースにした口腔診断学」の創設

    笹野 高嗣, 阪本 真弥, 庄司 憲明, 古内 寿, 佐藤 しづ子, 菅原 由美子, 飯久保 正弘, 小野寺 大, 駒井 伸也, 栗原 直之, 小嶋 郁穂

    歯科放射線　47　(1-4)　44-44　2008/03

    Publisher: (NPO)日本歯科放射線学会

    ISSN： 0389-9705

    eISSN： 2185-6311

Show all ︎Show first 5

Books and Other Publications 5

  1. 歯科放射線学

    岡野, 友宏, 小林, 馨, 有地, 榮一郎, 勝又, 明敏, 林, 孝文

    医歯薬出版　2024/03

    ISBN: 9784263456811

  2. 歯科国試パーフェクトマスター歯科放射線学

    飯久保 正弘, 村上 秀明, 小嶋 郁穂, 眞嶋みなみ

    医歯薬出版　2021/09

    ISBN: 9784263458631

  3. 解説と例題でわかる 歯科放射線テキスト

    小嶋郁穂、飯久保正弘

    永末書店　2021/01/08

  4. 口腔内科学

    小嶋郁穂, 阪本真弥, 笹野高嗣

    永末書店　2016/03/18

    ISBN: 9784816013041

  5. 基本臨床画像診断 口内法X線写真

    小嶋郁穂, 阪本真弥, 笹野高嗣

    医歯薬出版株式会社　2013/12/20

Presentations 125

  1. CNNを用いた鮮明化パノラマ画像における下顎第一小臼歯の複数根管識別の診断精度の検討

    山村聡太郎, 小嶋郁穂, 髙屋英知, 園部真也, 嶋田雄介, 飯久保正弘

    第8回日本メディカルAI学会学術集会　2026/06/05

  2. Optimization of Quantitative Bone SPECT/CT Analysis for Jaw Lesions: Correction for Individual Variability

    Anna Hatano, Ikuho Kojima, Hayato Odagiri, Akihito Usui, Tomohiro Kaneta

    SNMMI 2026 Annual Meeting　2026/05/31

  3. 18F-FDG PET/CTにてRouvièreリンパ節転移との鑑別を必要としたCarotidynia様の頸動脈壁肥厚の1例

    渡辺尚子, 小嶋郁穂, 森下陽平, 山口拓磨, 江副祐史, 飯久保正弘

    日本歯科放射線学会第66回学術大会　2026/05/30

  4. Influence of PET/CT misregistration with metal artifacts from dental prostheses on SUV quantification in SiPM PET/CT

    Naoko Tagaino, Watanabe, Ikuho Kojima, Hiroyasu Kodama, Kentaro Takanami, Hayato Odagiri, Hiroko Okawa, Masahiro Iikubo

    15th Asian Congress of Oral and Maxillo-Facial Radiology　2026/04/30

  5. Retrospective Evaluation of Diagnostic Quality and Visibility of Maxillary and Mandibular Incisors Using Tomosynthesis Panoramic Radiography

    Nur Redannia Redzuan, Ikuho Kojima, Mihoko Suzuki, Masahiro Iikubo

    15th Asian Congress of Oral and Maxillo-Facial Radiology　2026/04/30

  6. 海綿骨を再現した下顎骨ファントムの設計とCT評価

    鈴木美帆子, 小嶋郁穂, 飯久保正弘, 都木利之, 青木 徹, 森井久史, 小池昭史

    令和７年度生体医歯工学共同研究拠点成果報告会　2026/03/05

  7. CTにて側頭筋内に著明な高吸収構造のみられた Melnick-Needles 症候群の1例

    飯久保正弘, 金城皓平, 西村壽晃, 金髙弘恭, 小川徹, 嶋田雄介, 小嶋郁穂

    日本歯科放射線学会第44回関西・九州合同地方会　2025/12/13

  8. 多数歯欠損と顔面骨の形態異常を呈した Melnick-Needles 症候群の1例

    金城皓平, 西村壽晃, 金髙弘恭, 小川徹, 嶋田雄介, 小嶋郁穂, 飯久保正弘

    第86回東北大学歯学会　2025/12/12

  9. 長期に血中IgG４が高値を示したシェーグレン症候群の１症例

    畑岡英里, 菅原由美子, 小嶋郁穂, 嶋田雄介, 後藤弓里子, 熊本裕行, 飯久保正弘

    第37回NPO法人日本口腔科学会近畿地方部会　2025/12/06

  10. ここまでMIEr（みえる）画像鮮明化による歯科診療 Invited

    小嶋郁穂

    第35回日本口腔内科学会第38回日本口腔診断学会合同学術大会　2025/09/06

  11. 著明な口腔乾燥症状を認めシェーグレン症候群との鑑別を要したirAEの１症例

    後藤弓里子, 菅原由美子, 久米井亨仁, 畑岡英里, 小嶋郁穂, 熊本裕行, 飯久保正弘

    第35回日本口腔内科学会第38回日本口腔診断学会合同学術大会　2025/09/07

  12. PET/CT画像における口腔領域の腫瘤状アーチファクトに関する研究：歯科金属による影響の検討

    小嶋郁穂, 渡辺尚子, 飯久保正弘

    第35回日本口腔内科学会第38回日本口腔診断学会合同学術大会（2025年9月6日、仙台国際センター）　2025/09/06

  13. A case of temporal osteoid osteoma with pain of the temporomandibular joint

    Yoshinori Hokin, Ikuho Kojima, Shinnosuke Nogami, Masatoshi Chiba, Shin Hitachi, Yohei Morishita, Akira Ohkoshi, Masahiro Iikubo

    The Annual sMeeting of the Japanese Society for Oral and Maxillofacial Radiology　2025/05/31

  14. Imaging identification model for multiple root canals of lower 1st premolar using convolutional neural network

    Sotaro Yamamura, Ikuho Kojima, Eichi Takaya, Shinya Sonobe, Yusuke Shimada, Masahiro Iikubo

    The 65th Annual Meeting of the Japanese Society of Oral and Maxillofacial Radiology　2025/05/31

  15. ペンブロリズマブ投与後に発症した唾液腺炎の１症例

    後藤弓里子, 久米井亨仁, 畑岡英里, 菅原由美子, 小嶋郁穂, 飯久保正弘, 熊本裕行

    第114回日本病理学会総会　2025/04/18

  16. Imaging Diagnosis of Common Diseases in the Oral maxillofacial Region. Invited

    Ikuho Kojima

    The 84th Annual Meeting of the Japanese Radiological Society, Symposium;Unseen Threats: Are You Missing Key Diagnoses in Oral and Dento-Maxillofacial Imaging? The Role of Medical-Dental Collaboration　2025/04/12

  17. Design of a mandibular phantom replicating cancellous bone

    Mihoko Suzuki, Ikuho Kojima, Masahiro Iikubo, Toru Aoki, Hisashi Morii, Akifumi Koike

    2025/03/05

  18. MRONJ に対する外科的治療により抗がん剤治療を再開し得た乳癌の1例

    新垣 理宣, 臼渕 公敏, 纐纈 衆, 東 友太郎, 杉本 るみ, 工藤 裕子, 小嶋 郁穂, 飯田 雅史, 杉浦 剛, 飯久保 正弘

    日本がん口腔支持療法学会第10回学術大会　2025/03/01

  19. Quantitativeness and usefulness of PET/CT with semiconductor detector in the oral and maxillofacial region. Invited

    Ikuho Kojima, Naoko Watanabe, Kentaro Takanami, Hiroyasu Kodama, Hayato Odagiri, Masahiro Iikubo

    The 64th Annual Scientific Meeting of the Japaneses Society of Nuclear Medicine　2024/11/09

  20. A case of malignant lymphoma: usefulness of FDG-PET/CT in dental disease management

    Naoko Watanabe, Ikuho Kojima, Tadanobu Aragaki, Masahiro Iikubo

    The 64th Annual Scientific Meeting of the Japaneses Society of Nuclear Medicine　2024/11/09

  21. 口内法エックス線画像でCKD-MBDによる顔面動脈の石灰化を認めた慢性腎臓病患者の１例

    嶋田雄介, 小嶋郁穂, 飯久保正弘

    日本歯科放射線学会第５回秋季学術大会　2024/10/26

  22. The Effect of Dental Metal Artifacts on PET/CT Quantification: Phantom Experiments for PET Imaging Conditions

    Naoko Watanabe, Ikuho Kojima, Hiroyasu Kodama, Hayato Odagiri, Kentaro Takanami, Masahiro Iikubo

    14th Asian Congress of Oral and Maxillo-Facial Radiology　2024/06/13

  23. A study on overcorrection of PET/CT images in the oral cavity: relationship with dental metal prostheses and metal artifacts on attenuation correction CT

    Ikuho Kojima, Kentaro Takanami, Naoko Watanabe, Hiroyasu Kodama, Hayato Odagiri, Masahiro Iikubo

    14th Asian Congress of Oral and Maxillo-Facial Radiology　2024/06/14

  24. The Effect of Dental Metal Artifacts on PET/CT Quantification: Phantom Experiments for Metal artifact reduction in attenuation correction.

    WATANABE Naoko, KOJIMA Ikuho, KODAMA Hiroyasu, ODAGIRI Hayato, TAKANAMI Kentaro, IIKUBO Masahiro

    2024/05/26

  25. A Study on overcorrection of PET/CT images in the oral cavity: relationship with standardized uptake value and dental metal prostheses

    KOJIMA Ikuho, TAKANAMI Kentaro, WATANABE Naoko, KODAMA Hiroyasu, ODAGIRI Hayato, Masahiro

    2024/05/26

  26. 骨内造影剤の可視化を評価する新たな顎骨ファントム作成とCT評

    小嶋郁穂, 鈴木美帆子, 飯久保正弘, 都木利之, 森井久史, 小池昭史, 青木 徹

    令和５年度生体医歯工学共同研究拠点成果報告会　2024/03/08

  27. 骨内造影剤の可視化と定量化に関するファントムのCT画像評価

    小嶋郁穂, 嶋田雄介, 飯久保正弘, 都木利之, 小池昭史, 青木 徹, 森井久史

    令和4年度生体医歯工学共同研究拠点成果報告会　2023/03/03

  28. 頸部CTで強直性脊椎炎が疑われた顎関節強直症の1例

    小嶋郁穂, 野上晋之介, 常陸 真, 嶋田雄介, 横山由加, 飯久保正弘

    日本歯科放射線学会 第234回関東地方会・第41回北日本地方会・第29回合同地方会　2022/08/27

  29. Imaging findings of arrested pneumatization and differentiation from other skull base lesions

    Ikuho Kojima, Yusuke Shimada, Masahiro Iikubo

    13th ACOMFR (Asian Congress of Oral Maxiilofacial Radiology), 62th annual scientific congress of Japanese Society for Oral and Maxillo-Facial Radiology　2022/06/04

  30. Root canal narrowing patterns of mandibular first premolars on panoramic radiographs according to the number of root canals diagnosed on cone beam computed tomographic images

    Yusuke Shimada, Ikuho Kojima, Takashi Nishioka, Maya Sakamoto, Masahiro Iikubo

    13th ACOMFR (Asian Congress of Oral Maxiilofacial Radiology), 62th annual scientific congress of Japanese Society for Oral and Maxillo-Facial Radiology　2022/06/04

  31. Narrowing pulp cavities associated with long-term steroid therapy: two case reports and literature review

    Naoko Watanabe, Yuka Yokoyama Sato, Ikuho Kojima, Yusuke Shimada, Yuriko Goto, Kuniyuki Izumita, Akira Kumasaka, Masahiro Iikubo

    13th ACOMFR (Asian Congress of Oral Maxiilofacial Radiology), 62th annual scientific congress of Japanese Society for Oral and Maxillo-Facial Radiology　2022/06/04

  32. 全顎的な歯髄腔の狭窄がみられたステロイド長期使用患者の２症例

    渡辺尚子, 横山由加, 小嶋郁穂, 嶋田雄介, 後藤弓里子, 泉田一賢, 熊坂 晃, 飯久保正弘

    日本歯科放射線学会第233回関東地方会　2022/03/05

  33. Diagnostic performance for oral cancer by quantitative evaluation of FDG-PET: Current status and future prospects Invited

    KOJIMA Ikuho

    2022/03/04

  34. Quantitative diagnostic accuracy of silicon photomultiplier PET/CT for oral cancer Invited

    KOJIMA Ikuho

    The 61st Annual Scientific Meeting of the Japanese Society of Nuclear Medicine　2021/11/06

  35. 小児歯科用CBCTにおける小照射野撮影の基礎的検討

    伊藤実咲, 小嶋郁穂, 小野寺 崇, 千田浩一

    第11回東北放射線医療技術学術大会　2021/10/30

  36. 小児歯科疾患における歯科用CBCTの180度撮影の有用性

    伊藤実咲, 小嶋郁穂, 小野寺 崇, 千田浩一

    第49回日本放射線技術学会秋季学術大会　2021/10/15

  37. 歯科用CBCTにおける基礎物理評価

    伊藤実咲, 小嶋郁穂, 小野寺 崇, 千田浩一

    第190回医用画像情報学会　2021/06/05

  38. リンパ節サイズに着目した半導体および非半導体PET装置の口腔扁平上皮癌リンパ節転移の診断精度

    小嶋郁穂, 高浪健太郎, 小川武則, 石川健一朗, 森下陽平, 石井 亮, 大越 明, 中目亜矢子, 飯久保正弘

    日本歯科放射線学会第61回学術大会　2021/05/23

  39. 先端巨大症患者の顎顔面頭蓋の形態的特徴に関するセファロ分析による研究

    田中篤史, 飯久保正弘, 小嶋郁穂, 熊坂 晃, 阪本真弥, 佐々木紀代, 福永智広, 溝口 到

    日本歯科放射線学会第1回秋季学術大会　2020/10/31

  40. 半導体検出器を搭載した新PET装置による舌がん原発腫瘍の検出能および腫瘍サイズとの相関に関する検討

    小嶋郁穂, 阪本真弥, 飯久保正弘

    第33回日本口腔診断学会・第30回日本口腔内科学会・第13回日本口腔検査学会合同学術大会　2020/10/05

  41. 複数根管を有する下顎第一小臼歯のパノラマエックス線写真における特徴的画像所見の検討

    嶋田雄介, 小嶋郁穂, 西岡貴志, 飯久保正弘, 阪本真弥

    日本歯科放射線学会第24回臨床画像大会　2019/11/23

  42. 耳下腺の非腫瘍性嚢胞様病変のMRI所見

    阪本真弥, 西岡貴志, 小川武則, 村田隆紀, 小嶋郁穂, 嶋田雄介, 飯久保正弘

    日本歯科放射線学会第24回臨床画像大会　2019/11/23

  43. 信号とピクセルの位置関係の違いによるPSF補正への影響

    白田健太, 田頭 豊, 佐々木博信, 小田桐逸人, 髙浪健太郎, 小嶋郁穂

    第9回東北放射線医療技術学術大会　2019/10/27

  44. Diagnostic accuracy of lymph node metastasis in oral cancer using a new PET scanner with semiconductor photomultiplier.

    Takenori Ogawa, Ikuho Kojima, Kentaro Takanami, Tetsu Takahashi

    2019/10/25

  45. Efficacy of the positron emission tomography scanner with semiconductor photomultiplier in diagnosis of lymph node metastases in oral cancer International-presentation

    Ikuho Kojima, Masahiro Iikubo, Takashi Nishioka, Maya Sakamoto

    22th International Congress of Dental and Maxillofacial Radiology　2019/08/24

  46. 新型PET装置による口腔癌リンパ節転移の診断精度の検討

    石川 健一朗, 小川 武則, 小嶋 郁穂, 大越 明, 佐藤 亜矢子, 香取 幸夫

    第189回日本耳鼻咽喉科学会青森県地方部会　2019/07/20

  47. 半導体検出器を搭載した新PET装置による口腔がんリンパ節転移の診断精度

    小嶋郁穂, 高浪健太郎, 小川武則, 外山由貴, 齋藤美穂子, 阪本真弥, 飯久保正弘, 髙橋 哲

    日本歯科放射線学会第60回学術大会　2019/06/16

  48. 半導体検出器を搭載した新世代PET/CT装置の口腔癌における有用性と今後の展望 Invited

    小嶋 郁穂

    第73回日本口腔科学会学術集会･第13回口腔顎顔面核医学フォーラム　2019/04/20

  49. PET/CT画像におけるメタルアーチファクト除去処理を用いた減弱補正効果の検討

    白田健太, 藤盛陽介, 児玉裕康, 小田桐逸人, 髙浪健太郎, 小嶋郁穂

    日本核医学会第84回北日本地方会　2018/10/27

  50. 根尖性歯周炎由来の瘻孔が疑われた頬粘膜憩室様病変の１例

    飯久保正弘, 古内 壽, 阪本真弥, 熊坂 晃, 小嶋郁穂, 菅原由美子, 庄司憲明, 永井宏和, 髙橋 哲, 笹野高嗣

    第23回日本歯科放射線学会臨床画像大会　2018/10/14

  51. 半導体検出器を搭載した新PET装置による舌がん原発腫瘍の検出能の検討

    小嶋郁穂, 阪本真弥, 飯久保正弘, 高浪健太郎, 外山由貴, 古内 壽, 小川武則, 永井宏和, 宮下 仁, 髙橋 哲

    第23回日本歯科放射線学会臨床画像大会　2018/10/14

  52. 歯冠切除マウスを用いた脳卒中後回復過程における咬合不全の影響

    中村和浩, 小嶋郁穂, 石川達哉

    第61回日本脳循環代謝学会学術集会　2018/10

  53. PET/CT画像におけるメタルアーチファクト除去処理を用いた減弱補正効果の検討

    白田健太, 藤盛陽介, 児玉裕康, 小田桐逸人, 髙浪健太郎, 小嶋郁穂

    日本核医学技術学会第24回東北地方会総会学術大会　2018/09/01

  54. 舌腫瘍を契機に診断されたメトトレキサート関連リンパ増殖性疾患(MTX-LD)の1例

    村田隆紀, 小嶋郁穂, 阪本真弥, 宮下仁, 齊藤美穂子, 外山由貴, 高浪健太郎

    第47回頭頸部・胸部画像研究会　2018/05/19

  55. 口腔癌多発転移との鑑別を要したメトトレキサート関連リンパ増殖性疾患（MTX-LPD）の1例

    阪本真弥, 小嶋郁穂, 飯久保正弘, 笹野高嗣, 宮下 仁, 纐纈 衆, 川井 忠, 高橋 哲, 村田隆紀, 外山由貴

    第59回日本歯科放射線学会学術大会　2018/05

  56. 口腔癌頸部リンパ節転移の節外進展診断における3 テスラblack-blood MR imaging法の有用性

    阪本真弥, 小嶋郁穂, 飯久保正弘, 西岡貴志, 笹野高嗣, 伊藤康一, 青木孝文, 小川武則, 森 士朗, 小玉哲也

    第59回日本歯科放射線学会学術大会　2018/05

  57. 歯科用ＣＴアーチファクト除去ソフトが垂直歯根破折の診断精度に与える影響.

    飯久保正弘, 泉田一賢, 熊坂 晃, 西岡貴志, 小嶋郁穂, 笹野高嗣

    日本歯科放射線学会第37回関西・九州合同地方会　2017/12

  58. Excessive Lateral Dental Arch Expansion in Experimentally Developed Acromegaly-like Rats. International-presentation

    Iikubo M, Kojima I, Sakamoto M, Sasano T

    The 31th IADR-SEA and 28th SEAADE　2017/08

  59. 下顎骨骨炎が先行して発症した高安動脈炎の1例

    小嶋郁穂, 阪本真弥, 飯久保正弘, 白井剛志, 大田英揮, 常陸 真, 村田隆紀, 明石敏昭, 笹野高嗣

    第58回日本歯科放射線学会学術大会　2017/06/03

  60. Diagnostic Performance of MR Imaging of Three Major Salivary Glands for Sjögren’s Syndrome International-presentation

    Kojima I, Sakamoto M, Iikubo M, Sasano T

    21th International Congress of Dental and Maxillofacial Radiology　2017/04/26

  61. 口腔癌の骨浸潤評価と顎骨切除法に関する臨床学的検討：病理組織切片と各術前画像診断との比較

    纐纈 衆, 宮下 仁, 小嶋 郁穂, 阪本 真弥, 森 士朗, 山内健介, 野上晋之介, 川井 忠, 熊本 裕行, 髙橋 哲

    第61回日本口腔外科学会学術大会　2016/11/25

  62. シェーグレン症候群における唾液腺MR imagingの診断精度 －正診率83％の高空間分解能3D MR sialography－

    小嶋郁穂, 阪本真弥, 飯久保正弘, 熊本裕行, 室井 梓, 菅原由美子, 佐藤しづ子, 笹野高嗣

    第26回日本口腔内科学会・第29回日本口腔診断学会合同学術大会　2016/09/23

  63. 3 テスラblack-blood MR imagingが口腔癌患者の頸部リンパ節転移診断に有用であった2症例

    小嶋郁穂, 阪本真弥, 飯久保正弘, 小川武則, 渡邉みか, 大田英揮, 村田隆紀, 森 士朗, 小玉哲也, 笹野高嗣

    第57回日本歯科放射線学会学術大会　2016/06/18

  64. 口腔癌の頸部リンパ節転移診断における3 テスラblack-blood MR imagingの有用性について

    阪本真弥, 小嶋郁穂, 飯久保正弘, 近藤千裕, 伊藤康一, 青木孝文, 小川武則, 森 士朗, 小玉哲也, 笹野高嗣

    第57回日本歯科放射線学会学術大会　2016/06/18

  65. シェーグレン症候群の耳下腺,顎 下腺,舌下腺のMRIに関する診断学的研究 ―MR信号強度不均一とMR sialography点状高信号域の診断精度について―

    嶋田雄介, 小嶋郁穂, 阪本真弥, 飯久保正弘, 室井梓, 菅原由美子, 佐藤しづ子, 笹野高嗣

    第28回日本口腔診断学会学術大会　2015/09/04

  66. ＣＴ画像にみられる根管充填剤による歯根破折様アーチファクトについて

    飯久保正弘, 嶋田雄介, 佐々城 真, 熊坂 晃, 小嶋郁穂, 阪本真弥, 笹野高嗣

    第28回日本口腔診断学会学術大会　2015/09/04

  67. 東北大学病院歯科部門における卒前臨床実習および卒後臨床研修に対する外来患者の意識調査

    室井 梓, 飯久保正弘, 嶋田雄介, 橋本直也, 熊坂晃, 佐々城真, 小嶋郁穂, 庄司憲明, 笹野高嗣

    第28回日本口腔診断学会学術大会　2015/09

  68. IGF-Iは抜歯後の歯槽骨吸収を抑制する

    熊坂 晃, 飯久保 正弘, 小嶋郁穂, 庄司憲明, 阪本真弥, 笹野 高嗣

    第27回日本口腔診断学会・第24回日本口腔内科学会合同学術大会　2014/09

  69. 水平的歯根破折に関する画像診断学的研究－角度の異なる歯根破折線の検出能に関する二等分法、平行法および歯科用CTの比較－

    佐々城 真, 飯久保 正弘, 橋本直也, 嶋田 雄介, 小嶋郁穂, 阪本真弥, 笹野高嗣

    第27回日本口腔診断学会・第24回日本口腔内科学会合同学術大会　2014/09

  70. 歯科用ＣＴにおける根管充填材のアーチファクトに関する検討―第２報 撮影モードおよび位置付けによる影響―

    飯久保 正弘, 小佐野 貴識, 小林 馨, 勝又 明敏, 佐野 司, 有地 榮一朗, 西岡 貴志, 小嶋 郁穂, 阪本 真弥, 笹野 高嗣

    第55回NPO法人日本歯科放射線学会学術大会　2014/06/06

  71. シェーグレン症候群における顎下腺および舌下腺のMRIと診断学的意義について 第３報：MR sialography点状高信号域およびMR信号強度不均一の診断精度について

    小嶋郁穂, 阪本真弥, 飯久保正弘, 酒井梓, 菅原由美子, 佐藤しづ子, 笹野高嗣

    第１8回日本歯科放射線学会臨床画像大会　2013/11/02

  72. シェーグレン症候群患者の唾液腺MR-sialographyにおける点状高信号域の検出能―3D法と2D法の比較検討―

    小嶋郁穂, 阪本真弥, 飯久保正弘, 酒井 梓, 菅原由美子, 佐藤しづ子, 笹野高嗣

    第26回日本口腔診断学会・第23回日本口腔内科学会合同学術大会　2013/09/13

  73. Artifacts appeared in CBCT induced by root canal filling materials International-presentation

    Masahiro Iikubo, Takashi Osano, Kaoru Kobayashi, Tsukasa Sano, Kenji Seki, Mamoru Wakoh, Akitoshi Katsumata, Eiichiro Ariji, Ikuho Kojima, Maya Sakamoto, Takashi Sasano

    IADR　2013/08

  74. 多形腺腫とワルチン腫瘍のＭＲＩ：皮膜様増強効果と病理組織所見との関係

    阪本真弥, 飯久保正弘, 小嶋郁穂, 高橋昭喜, 志賀清人, 笹野高嗣

    第５４回日本歯科放射線学会総会　2013/05/31

  75. 歯科放射線学に対する歯学部学生の意識調査

    田代瑞行, 内沼裕輔, 宮本祥行, 飯久保正弘, 酒井梓, 西岡貴志, 小嶋郁穂, 菅原由美子, 佐藤しづ子, 古内壽, 庄司憲明, 阪本真弥, 笹野高嗣

    第５４回日本歯科放射線学会総会　2013/05/31

  76. ラット抜歯窩治癒に及ぼすＩＧＦ－Ｉ投与効果に関する研究

    熊坂晃, 飯久保正弘, 小嶋郁穂, 庄司憲明, 阪本真弥, 笹野高嗣

    第５４回日本歯科放射線学会総会　2013/05/31

  77. インプラント術前ＣＴ画像による下顎骨断面形態の検討

    古内 壽, 小嶋郁穂, 酒井 梓, 金田直人, 西岡貴志, 菅原由美子, 佐藤しづ子, 飯久保正弘, 庄司憲明, 阪本真弥, 笹野高嗣

    第５４回日本歯科放射線学会総会　2013/05/31

  78. シェーグレン症候群における顎下腺および舌下腺のMRIと診断学的意義について 第２報：MRI所見と安静時唾液分泌量との関連について

    小嶋郁穂, 阪本真弥, 酒井梓, 菅原由美子, 佐藤しづ子, 佐藤恭子, 飯久保正弘, 笹野高嗣

    第１７回日本歯科放射線学会臨床画像大会　2012/11/09

  79. 歯根破折歯の画像診断ガイドライン作成のためのプロジェクト研究 －歯科用ＣＴにおける根管充填剤のアーチファクトに関する検討－

    飯久保 正弘, 佐野 司, 小林 馨, 関 健次, 勝又 明敏, 有地 榮一郎, 神尾 崇, 小佐野 貴識, 笹野 高嗣, 和光 衛, 小嶋 郁穂, 阪本 真弥

    第１７回日本歯科放射線学会臨床画像大会　2012/11/09

  80. Evaluation of effect of x-ray projection angle in detection of horizontal root fracture : Comparison of paralleling technique, bisecting technique intraoral radiography and CBCT

    Takashi Kamio, Masahiro Iikubo, Tsukasa San, Chinami Igarashi, Kaoru Kobayash, Kenji Seki, Tomohiro Okano, Akitoshi Katsumata, Eiichiro Arij, Takashi Sasano, Ikuho Kojima, Maya Sakamoto

    The Asian Congress of Oral and Maxillofacial Radiology　2012/09/14

  81. シェーグレン症候群における顎下腺および舌下腺のMRIと診断学的意義について

    阪本真弥, 小嶋郁穂, 酒井梓, 佐藤恭子, 菅原由美子, 佐藤しづ子, 飯久保正弘, 笹野高嗣

    第５３回日本歯科放射線学会総会　2012/06/01

  82. 歯根破折歯の画像診断ガイドライン作成のためのプロジェクト研究 －エックス線投影角度が水平的歯根破折線の検出に及ぼす影響－

    飯久保 正弘, 佐野 司, 五十嵐 千浪, 関 健次, 勝又 明敏, 有地 榮一郎, 笹野 高嗣, 神尾 崇, 小嶋 郁穂, 阪本 真弥

    第５３回日本歯科放射線学会総会　2012/06/01

  83. Detection of Horizontal Root-fracture: Comparison of CT and Intra-oral Radiography International-presentation

    M Iikubo, T Sano, K Kobayashi, I Kojima, M Sakamoto, N Shoji, T Sasano, A Katsumata, E Ariji

    The 41th Annual Meeting of American Association for Dental Research　2012/03/21

  84. 誤飲・誤嚥の危険を回避するためにワイヤ結紮を行い抜歯した鼻腔内過剰歯の一例

    飯久保正弘, 金田直人, 熊坂晃, 佐々城真, 佐藤恭子, 小嶋郁穂, 古内壽, 庄司憲明, 阪本真弥, 笹野高嗣

    第１６回日本歯科放射線学会臨床画像大会　2011/10/01

  85. 唾液腺腫瘍のMRI、腫瘍鑑別における皮膜様増強効果の意義について

    阪本真弥, 飯久保正弘, 小嶋郁穂, 志賀清人, 高橋昭喜, 笹野高嗣

    第１６回日本歯科放射線学会臨床画像大会　2011/10/01

  86. 唾液腺腫瘍のＭＲ診断における被膜様増強効果の意義について

    阪本真弥, 飯久保正弘, 小嶋郁穂, 笹野高嗣

    第２１回日本口腔粘膜学会　2011/09/24

  87. MRI findings of parotid tumors: Basal cell adenoma VS basal cell adenocarcinoma International-presentation

    Kojima I, Sakamoto M, Iikubo M, Yamamura MJ, Mugikura S, Takahashi S, Ogawa T, Shiga K, Watanabe M, Sasano T

    The 18th International Congress of Dento-Maxillo-Facial Radiology　2011/05/25

  88. Mechanisms of edematous changes in masseter muscle evoked by muscle pain International-presentation

    Iikubo M, Yamamura MJ, Li L, Sasaki M, Kojima I, Satoh-Kuriwada S, Shoji N, Sakamoto M, Kodama T, Sasano T

    The 18th International Congress of Dento-Maxillo-Facial Radiology　2011/05/25

  89. Contribution of genetic and non-genetic factors in the new inbred ankylosis model International-presentation

    Yamamura MJ, Iikubo M, Sakamoto M, Kojima I, Mori S, Inui M, Shimoda S, Kobayashi K, Ono T, Sasano T

    The 18th International Congress of Dento-Maxillo-Facial Radiology　2011/05/25

  90. Characteristics of acinic cell carcinoma of the parotid gland on MR imaging International-presentation

    Sakamoto M, Kojima I, Iikubo M, Yamamura MJ, Mugikura S, Takahashi S, Ogawa T, Shiga K, Watanabe M, Sasano T

    The 18th International Congress of Dento-Maxillo-Facial Radiology　2011/05/25

  91. Non-operative treatment for odontogenic maxillary sinusitis using irrigation through the root canal International-presentation

    Iikubo M, Kojima I, Yamamura JM, Shoji N, Sakamoto M, Sasano T

    8th Asian congress of Oral and Maxillofacial Radiology　2010/11/14

  92. Morphological study on the dental arch in experimentally developed acromegaly-like rats International-presentation

    Kojima I, Iikubo M, Sakamoto M, Sasano T

    8th Asian congress of Oral and Maxillofacial Radiology　2010/11/14

  93. Chronological changes of ankylosis in the newly developed recombinant selective-congenic model International-presentation

    Munemasa John Yamamura, Masahiro Iikubo, Maya Sakamoto, Ikuho Kojima, Shiro Mori, Fumiko Date, Shinji Shimoda, Kaoru Kobayashi, Masao Ono, Takashi Sasano

    8th Asian congress of Oral and Maxillofacial Radiology　2010/11/14

  94. 咬筋における痛みと浮腫性変化に関する研究

    飯久保正弘, 山村宗正, 李 麗, 森 士朗, 小嶋郁穂, 佐藤しづ子, 庄司憲明, 阪本真弥, 笹野高嗣

    日本機械学会2010年度年次大会　2010/09/05

  95. 唾液腺腫瘍のMRI 誤診しやすい悪性腫瘍

    阪本真弥, 志賀清人, 小嶋郁穂, 飯久保正弘, 笹野高嗣, 高橋昭喜

    第15回日本歯科放射線学会臨床画像大会　2010/09/03

  96. 東北大学病院におけるインプラント術前CT検査の推移と臨床統計学的検討

    古内壽, 小嶋郁穂, 酒井梓, 佐藤恭子, 阪本真弥, 庄司憲明, 飯久保正弘, 佐藤しづ子, 菅原由美子, 笹野高嗣

    日本歯科放射線学会第211回関東地方会・第30回北日本地方会・第18回合同地方会　2010/08/07

  97. 咬筋における痛みと浮腫性変化に関する研究 -痛み刺激による血漿漏出について-

    飯久保正弘, 山村宗正, 小嶋郁穂, 佐藤しづ子, 庄司憲明, 阪本真弥, 笹野高嗣

    第２３回日本口腔診断学会　2010/05/29

  98. 東北大学病院における問診票導入による医療面接時間の短縮効果について

    庄司憲明, 金田直人, 飯久保正弘, 山村宗正, 伊藤あゆみ, 佐藤恭子, 酒井梓, 小嶋郁穂, 菅原由美子, 佐藤しづ子, 古内壽, 阪本真弥, 笹野高嗣

    第２３回日本口腔診断学会　2010/05/29

  99. 東北大学病院附属歯科医療センターにおける新来患者の主訴に関する疫学調査

    小嶋郁穂, 飯久保正弘, 金田直人, 阪本真弥, 佐々城真, 熊坂晃, 鈴木宏尚, 伊藤あゆみ, 山村宗正, 佐藤恭子, 酒井梓, 佐藤しづ子, 菅原由美子, 古内壽, 庄司憲明, 笹野高嗣

    第２３回日本口腔診断学会　2010/05/29

  100. 新たに開発した関節強直症モデルマウスにおける強直症の経時的変化について

    山村宗正, 飯久保正弘, 森 士朗, 小嶋郁穂, 阪本真弥, 下田信治, 小林 馨, 笹野高嗣

    第５１回日本歯科放射線学会　2010/04/23

  101. 咬筋における痛みと浮腫性変化に関する研究 -発痛物質による血漿漏出について-

    飯久保正弘, 山村宗正, 小嶋郁穂, 佐藤しづ子, 庄司憲明, 阪本真弥, 森士朗, 笹野高嗣

    第５１回日本歯科放射線学会　2010/04/23

  102. ナノバブルと高周波超音波を用いた画像診断システムに関する研究 第1報 微小腫瘍の診断精度に関する検討

    阪本真弥, 小嶋郁穂, 森士朗, 山村宗正, 飯久保正弘, 笹野高嗣

    第５１回日本歯科放射線学会　2010/04/23

  103. ナノバブルと高周波超音波を用いた画像診断システムに関する研究 第２報 悪性腫瘍の治療にともなう腫瘍内血管密度の変化

    小嶋郁穂, 阪本真弥, 森士朗, 山村宗正, 飯久保正弘, 笹野高嗣

    第５１回日本歯科放射線学会　2010/04/23

  104. A case of mandibular ossifying fibroma showed an increased FDG uptake in the FDG-PET/CT International-presentation

    I Kojima, M Sakamoto, M Iikubo, H Miyashita, S Mori, J Kurihara, H Kawamura, T Sasano

    The 7th Asian Congress of Oral and Maxillofacial Radiology　2008/11/20

  105. A genetic mode of regulation for the growth correlation of mandible and craniomaxilla in mice International-presentation

    Maya Sakamoto, Masahiro Iikubo, Ikuho Kojima, Munemasa John Yamamura, Takashi Sasano, Ming-Cai Zhang, Shiro Mori, Masao Ono

    The 7th Asian Congress of Oral and Maxillo-Facial Radiology　2008/11/20

  106. 咀嚼感覚消失および咀嚼障害を訴えた三叉神経鞘腫の１例

    飯久保正弘, 古内 寿, 阪本真弥, 小嶋郁穂, 笹野高嗣

    第２１回日本口腔診断学会　2008/09/18

  107. Histomorphologic Changes in the Mandibular Condyle of Acromegaly-like Rats International-presentation

    Kojima I, Iikubo M, Kobayashi A, Ikeda H, Sakamoto M, Sasano T

    ８６th International Association for Dental Research　2008/07/02

  108. 末端肥大症様ラットモデルにおける下顎頭過成長の組織学的変化

    小嶋郁穂, 飯久保正弘, 阪本真弥, 池田秀敏, 笹野高嗣

    第5回バイオサイエンスシンポジウム　2008/05/19

  109. 末端肥大症様ラットモデルにおける顎・口腔組織の動的変化に関する研究-下顎頭の形態学的変化および組織学的変化について-

    小嶋郁穂, 飯久保正弘, 小林あかね, 池田秀敏, 阪本真弥, 笹野高嗣

    第３回アクロメガリーフォーラム　2007/10/06

  110. 咀嚼筋の運動障害を引き起こした三叉神経鞘腫の２症例

    飯久保正弘, 古内 寿, 阪本真弥, 小嶋郁穂, 笹野高嗣

    第１５回日本歯科放射線学会合同地方会　2007/07/21

  111. A case of masticatory disturbance incidental to trigeminal schwannoma: changes in occlusal force and masticatory sensation before and after radiosurgery. International-presentation

    Iikubo M, Sakamoto M, Furuuchi T, Fujimura M, Tominaga T, Takahashi S, Kojima I, Sasano T

    １６th International Congress of DentoMaxilloFacial Radiology　2007/06/26

  112. High Serum Levels of IGF-I Contribute to Promotion of Endochondral Ossification in Mandibular Condyle, and Cause its Specific Elongation in Acromegaly-like Rats International-presentation

    Kojima I, Iikubo M, Kobayashi A, Ikeda H, Sakamoto M, Sasano T

    16 th International Congress of DentoMaxilloFacial Radiology　2007/06/26

  113. 本学歯学部附属病院における新来患者の動向？第3報 診療および教育に対する意識調査？

    栗原直之, 阪本真弥, 小嶋郁穂, 示野陽一, 大場麻美, 小野寺大, 菅原由美子, 佐藤しづ子, 古内寿, 飯久保正弘, 庄司憲明, 駒井伸也, 笹野高嗣

    第５０回東北大学歯学会　2006/12/13

  114. 頸部リンパ節に多発した胚中心進展性異形成の一例

    飯久保 正弘, 古内 寿, 阪本 真弥, 菅原 由美子, 西岡 貴志, 小嶋 郁穂, 示野 陽一, 庄司 憲明, 笹野 高嗣

    第１１回日本歯科放射線学会臨床画像大会　2006/10/28

  115. 末端肥大症様ラットモデルの作成および顎・口腔領域の変化-とくに顎骨と舌組織の変化の可逆性について-

    飯久保正弘, 小嶋郁穂, 池田秀敏, 阪本真弥, 笹野高嗣

    第２回アクロメガリーフォーラム　2006/10/07

  116. 末端肥大症様ラットモデルにおける顎・口腔組織の動的変化に関する研究−第４報 舌の形態学的、病理組織学的変化について−

    小嶋郁穂, 飯久保正弘, 小林あかね, 阪本真弥, 笹野高嗣

    第１４会日本歯科放射線学会合同地方会　2006/07/08

  117. 末端肥大症様ラットモデルにおける顎・口腔組織の動的変化に関する研究-第３報 下顎頭過成長の組織学的変化について-

    小嶋郁穂, 飯久保正弘, 小林あかね, 阪本真弥, 笹野高嗣

    第４７回日本歯科放射線学会　2006/05/12

  118. 末端肥大症様ラットモデルにおける顎口腔領域の動的変化に関する研究 -第４報 歯列弓の形態学的検討-

    飯久保正弘, 小林あかね, 小嶋郁穂, 阪本真弥, 笹野高嗣

    第１９回日本口腔診断学会　2006/04/21

  119. 末端肥大症様ラットモデルにおける顎口腔領域の動的変化に関する研究 -第5報 下顎頭過成長の組織学的検討-

    小嶋郁穂, 飯久保正弘, 小林あかね, 阪本真弥, 笹野高嗣

    第１９回日本口腔診断学会　2006/04/21

  120. 末端肥大症ラットモデルにおける顎口腔組織の動的変化に関する研究-第２報 下顎骨過成長の画像解析-

    小嶋郁穂, 飯久保正弘, 小林あかね, 阪本真弥, 笹野高嗣

    第４６回日本歯科放射線学会総会　2005/05/12

  121. 末端肥大症ラットモデルにおける顎・口腔領域の動的変化に関する研究-第1報 下顎骨、上顎骨、大腿骨の成長について-

    飯久保正弘, 小林あかね, 小嶋郁穂, 橋本憲二, 阪本真弥, 笹野高嗣

    第１７回日本口腔診断学会　2004/05/15

  122. 末端肥大症ラットモデルにおける顎・口腔領域の動的変化に関する研究-第2報 下顎骨の形態学的変化について-

    小嶋郁穂, 飯久保正弘, 小林あかね, 橋本憲二, 阪本真弥, 笹野高嗣

    第１７回日本口腔診断学会　2004/05/15

  123. 末端肥大症ラットモデルにおける顎・口腔領域の動的変化に関する研究-第３報 舌の形態学的、病理組織学的変化について-

    小林あかね, 飯久保正弘, 小嶋郁穂, 橋本憲二, 阪本真弥, 笹野高嗣

    第１７回日本口腔診断学会　2004/05/15

  124. IGF-I Stimulates Mandibular Enlargement in Rats Similar to Acromegalic Patients International-presentation

    Iikubo M, Ikeda H, Kobayashi A, Kojima I, Hashimoto K, Sakamoto M, Shoji N, Sasano T

    IADR 82th General Session& Exhibition　2004/03/10

  125. 末端肥大モデルラットにおける顎口腔組織の動的変化に関する研究-第１報 モデルラットの作成と骨格系の変化について-

    飯久保正弘, 小林あかね, 小嶋郁穂, 橋本憲二, 阪本真弥, 笹野高嗣

    第44回日本歯科放射線学会総会　2003/10/02

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Research Projects 26

  1. 深層学習によるトモシンセシス搭載パノラマX線画像の３次元根管形態予測モデルの開発

    嶋田 雄介, 飯久保 正弘, 小嶋 郁穂

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2025/04/01 - 2030/03/31

  2. フォトン・カウンティング機能による顎骨の多元分析を可能とした歯科用ＣＴの開発

    飯久保 正弘, 青木 徹, 山内 健介, 河合 泰輔, 石幡 浩志, 五十嵐 千浪, 藤原 航三, 小嶋 郁穂

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2024/04/01 - 2028/03/31

  3. 新世代半導体PETとSPECTのRadiomics解析による顎骨疾患の治療戦略的画像診断法の開発

    小嶋 郁穂, 飯久保 正弘, 高浪 健太郎

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2024/04/01 - 2028/03/31

  4. Understanding Odontogenic Focal Infection and New Approach in Oral Management Based on Integrated Analysis of Clinical, Imaging, and Bacterial Flora

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2024/04/01 - 2027/03/31

  5. CT画像における骨内造影剤の可視化と定量化に関する研究

    小嶋 郁穂, 鈴木美帆子, 嶋田 雄介, 飯久保 正弘, 青木 徹, 森井久史

    System: 2025年度 生体医歯工学共同研究

    Institution: 東北大学病院

    2025/04 - 2026/03

  6. CT画像における骨内造影剤の可視化と定量化に関する研究

    小嶋 郁穂, 鈴木美帆子, 嶋田 雄介, 飯久保 正弘, 青木 徹, 森井久史

    System: 2024年度生体医歯工学共同研究

    Institution: 東北大学病院

    2024/04 - 2025/03

  7. フォトン・カウンティング機能を搭載した新しい組織分析型歯科用ＣＴの開発

    飯久保 正弘, 青木 徹, 佐々木 啓一, 河合 泰輔, 石幡 浩志, 小林 馨, 荒木 和之, 藤原 航三, 小嶋 郁穂

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(B)

    Category: 基盤研究(B)

    Institution: 東北大学

    2020/04/01 - 2024/03/31

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    歯科用コーンビームCT（歯科用CT）は、Ｘ線不透過性の極めて高いインプラントや歯科材料が撮影範囲に含まれるため、アーチファクトの軽減と組織のＸ線吸収値の安定化（定量化）が課題である。近年、微弱なＸ線を感知する素子としてテルル化カドミウム（CdTe）半導体が注目されている。CdTe半導体は、Ｘ線を直接感知することができるため検出感度や画質の低下が少なく、光子（フォトン）をそのままカウントすることにより、物質の原子番号や電子密度によるエネルギースペクトルの変化を定量評価することが可能である。本研究は、CdTe半導体検出器を歯科用CTに搭載することで、歯科用CTに実用可能なフォトン・カウンティング機能を開発し、骨や歯のエックス線に対するモノクロマティック特性に依存した多元的分析が可能であり、かつアーチファクトの極めて少ない、高い濃度分解能、空間分解能を有した歯科用CT装置の実現化を目指すものである。 2020年度は １）高電圧出力を可能とした管球をプロトタイプの歯科用CT開発用冶具（以下、開発用冶具）に設置した。 ２）抜去歯に対し、CdTe半導体検出器によるフォトン・カウンティング機能を用いて、エナメル質と象牙質の実効原子番号及び電子密度の算出を可能とする計算式を検討し、そのカラー画像化を試みた。その結果、エナメル質と象牙質には明瞭な差が確認され、フォトンカウンティングを用いることで歯の実効原子番号、電子密度の算出及びカラー画像化が可能であることが示唆された。

  8. CT画像における骨内造影剤の可視化と定量化に関する研究

    小嶋郁穂, 嶋田雄介, 飯久保正弘, 青木 徹, 森井久史

    System: 生体医歯工学共同研究

    2022/04 - 2023/03

  9. Study of the diagnostic imaging using quantitative analysis of MRI and PET for minimally invasive treatment of oral cancers

    KOJIMA Ikuho

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2018/04/01 - 2022/03/31

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    Preoperative imaging diagnosis of oral cancer requires accurate evaluation of the extension and lymph node metastasis, which affects treatment planning and outcomes. We investigated imaging conditions specific to the head and neck region using a PET with a silicon-semiconductor detector. We developed a new MR imaging method to improve the detection of focal defects that are suspicious for lymph node metastasis. Compared to conventional PET imaging, these imaging methods improved the detection of small primary tumors, the evaluation of lesion extension, and the diagnostic accuracy of small lymph node metastases. Furthermore, the use of PET quantitative values resulted in very high diagnostic accuracy. The comprehensive imaging method obtained from the results of this study enables imaging diagnosis with superior diagnostic accuracy compared to conventional methods.

  10. 超微小転移リンパ節の精密診断と新化学療法に関する総合的研究 Competitive

    阪本真弥, 小玉哲也, 飯久保正弘, 小嶋郁穂

    System: 科学研究費補助金 基盤研究（B）

    2018 - 2020

  11. Study of diagnostic imaging methods of cervical lymph nodes metastasis using new high resolusion 3D MR imaging

    Kojima Ikuho

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2015/04/01 - 2019/03/31

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    We analyzed the usefulness of black-blood MR imaging (MSDE-VISTA) to detect small lymph node metastases in head and neck cancer, and obtained stable and good quality imaging with high resolution 3D imaging and blood flow artifact suppression.The MSDE-VISTA was superior to the conventional MR imaging in the ability to visualize focal defect and extranodal extension of the metastatic lymph nodes, which are findings suggestive of lymph node metastasis. Further, subtracion images of before and after contrast enhanced the MSDE-VISTA showed the best diagnostic performance. Thus, these results suggested that the MSDE-VISTA can detect early and accurately lymph node metastasis in imaging diagnosis of head and neck cancer.

  12. High-frequency ultrasound diagnostic imaging system to detect niche formation in the lymph nodes in a pre-metastatic phase

    Sakamoto Maya, KODAMA Tetsuya, ITO Koichi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2015/04/01 - 2018/03/31

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    To develop an image analysis system to detect niche formation leading to lymph node (LN) metastasis formation, changes in vascular architecture in the process of LN metastasis formation were analyzed using contrast micro CT imaging and contrast high frequency ultrasound imaging. In the present study, tumor cells were inoculated into the subiliac LN (SiLN) of LN-swollen mouse, MXH10/Mo/lpr, and then metastasis formation process in the proper axillary LN located downstream of SiLN in mouse lymph network was analyzed. The results showed that, in the early stage of LN metastasis, blood vessel density in the LN prior to LN size change was increased. However, angiogenesis in the LN at the early stage of LN metastasis could not be confirmed.

  13. Development of volume registration method for diagnosis of metastatic lymph node of head and neck cancer by ultrasound imaging

    Sakamoto Maya

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2013/04/01 - 2017/03/31

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    To detect lymph node micrometastasis, we developed a volume registration method for analyzing the vessel structure in the lymph node by using Scale-Invariant-Feature-Transform and Phase-Only Correlation methods. The algorithm developed here was for correcting images for evaluation of ultrasound images of the experimental metastatic lymph node, and also for calculating highly accurate information of blood vessel considering the dispersion value due to temporal change of luminance information and those before and after contrast agent administration. As a result, it was possible to eliminate misalignment and noise of the ultrasound images, and also extract the microstructure of the blood vessels in the metastatic lymph node.

  14. Comparative study on taste sensitivity between Japan and Thailand

    Shoji Noriaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2013/04/01 - 2017/03/31

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    Taste perception is influenced by several factors. However, it was unclear how food culture affects taste perception. In this study, we compared recognition taste thresholds between populations with different food culture, i.e. Thai and Japanese Adults. A matched case-control study was conducted in 168 healthy older adults (84 for each country). Recognition thresholds of sweet, salty, sour, bitter and umami were measured using Filter Paper Disc by stimulation at anterior and posterior tongue area. Spicy preference was measured by calibrated questionnaires. Interestingly, Thai older adults had much higher recognition thresholds of all tastes than those of Japanese (p<0.0001). Further, Thai adults had stronger preference on spicy food (p<0.0001). Our findings suggest that population from culture with stronger preference on spicy food such as Thai had higher recognition thresholds of all tastes than population with milder preference on spicy food like Japanese.

  15. New theory for pain control in the maxillofacial regions by sialorphin, saliva-derived antinociceptive modulator.

    Shoji Noriaki, SASANO TAKASHI, SUGIMOTO KOREAKI

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2012/04/01 - 2016/03/31

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    Recently, patients with atypical tooth pain, glossodynia and tempolomandibular disorder have been increasing and this phenomenon was recognized as social issues. This study was designed to determine whether sialorphin that displays analgesic activity can be effective for pain control in the maxillofacial regions both of the acute-pain model rats induced by formalin injection and of the chronic-pain ones induced by trigeminal (maxillary) nerve constriction. In conclusion, sialorphin had inhibitory effect both on the formalin-induced acute pain and on the chronic pain induced by nerve constriction.

  16. Stydy of IGF-I for oral and maxillofacial smart aging

    Kojima Ikuho

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2012/04/01 - 2016/03/31

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    We analyzed the longitudinal morphological changes in extraction sockets following sustained continuous subcutaneous infusion of insulin-like growth factor I (IGF-I). rats were subjected to right mandibular first molar extraction. Experimental rats received a continuous subcutaneous infusion of IGF-I by minipump. Control animals were treated with saline via the same method. All rats were then housed after stop of the infusion. Micro-CT scanning was performed immediately after tooth extraction and at regular intervals. New bone formation was markedly higher in the IGF-I-treated group as compared with the control group. The loss in alveolar ridge height in the IGF-I group was significantly lower than that in the control group at each time point after extraction on the buccal side and at 2, 3, and 6 weeks on the lingual side. IGF-I treatment increases the volume of newly formed bone and reduces the loss in alveolar ridge height following tooth extraction.

  17. Development of alveolar bone regenerative therapy using nano/microbubbles with IGF-I plasmid gene.

    IIKUBO Masahiro, SASANO Takashi, KOJIMA Ikuho, SAKAMOTO Maya, KODAMA Tetsuya, MORI Shiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2012/04/01 - 2015/03/31

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    The purpose of this study was to investigate the longitudinal morphological changes in extraction sockets following sustained IGF-I treatment. Fourteen rats were subjected to right mandibular first molar extraction. Experimental rats received a continuous subcutaneous infusion of IGF-I. Micro-computed tomography scanning was performed immediately after tooth extraction, and at 1, 2, 3 and 6 weeks after extraction. New bone formation was markedly higher in the IGF-I treated group as compared with the control group. The loss in alveolar ridge height in the IGF-I group was significantly lower than that in the control group at each time point after extraction on the buccal side, and at 2, 3 and 6 weeks on the lingual side. In conclusions, IGF-I treatment increases the volume of newly formed bone and reduces the loss in alveolar ridge height following tooth extraction.

  18. Development of real-time image analysis system of cervical lymph node network using nanobubbles

    SAKAMOTO Maya, KODAMA Tetsuya, IIKUBO Masahiro, KOJIMA Ikuho, MORI Shiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2012/04/01 - 2015/03/31

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    The aim of this study is to develop a new diagnostic imaging technique which can detect the head and neck cancer metastasis routes. In this study, MXH10 / Mo / lpr mice, which develop systemic swelling of lymph nodes up to 10 mm in diameter, were used as a lymph node metastasis model. As a method for visualization of lymph node network in real time, we examined a contrast ultrasound imaging system using nano-microbubbles. As a result, it was suggested that contrast ultrasound image analysis method using a nano-micro-bubbles might be a potential method clinically applicable to detection of lymphatic network.

  19. 唾液由来鎮痛物質による新たな顎顔面領域の慢性痛制御理論の確立 Competitive

    庄司 憲明, 杉本 是明, 笹野 高嗣, 小嶋 郁穂

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 挑戦的萌芽研究

    Category: 挑戦的萌芽研究

    Institution: 東北大学

    2010 - 2012

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    最近、非定型歯痛、舌痛症および顎関節症などの慢性痛患者は増加傾向にあり社会問題となっている。しかしながら、慢性痛に対する治療法は確立されておらず、診断および治療法の開発は急務であり責務である。近年、パスツール研究所の研究員により、ラット唾液からモルヒネの約3～6倍の鎮痛効果があるシアロルフィンが発見された。しかしながら、いまだこれら唾液由来の鎮痛物質が慢性痛にどのような効果をもたらすかについては明らかにされていない。また、これらの鎮痛効果の評価はラットの行動薬理学的評価であり、疼痛そのものを評価していない等の問題があるため、シアロルフィンを臨床に応用するためには、鎮痛効果の判定(定量)が不可欠である。そこで本研究では、我々が痛みストレスマーカーになることを発見した視床下部CRH(Corticotropin Releasing Hormone)遺伝子、下垂体POMC(proopiomelanocortin)遺伝子(以上、ストレス関連遺伝子)、三叉神経節P2×4レセプター遺伝子(慢性疼痛原因遺伝子)を指標としてシアロルフィンの鎮痛効果を定量的に評価することを目的とした。 H23年度はマウス頬部へホルマリン注射することにより疼痛刺激を与え、その疼痛モデルに対しシアロルフィンを投与しその鎮痛効果について疼痛行動回数を指標として検討した。その結果、シアロルフィン投与マウスの方がコントロールより疼痛行動回数が少なかった。また、シアロルフィンを投与したラットと生食を投与したラットで疼痛行動の回数の差が大きいのは5-10分と30-35分の時間帯であった。以上より、シアロルフィンが前者の時間帯はホルマリンによる第1相の疼痛を後者の時間帯は第2相の疼痛を抑制していることを示唆した。

  20. ナノバブルを用いたIGF-I長期発現プラスミドによる新たな顎骨再生治療法の開発 Competitive

    飯久保正弘, 阪本真弥, 笹野高嗣, 小嶋郁穂, 小玉哲也, 森士朗

    System: 科学研究費補助金 基盤研究（C）

    2010 - 2012

  21. An experimental study for developments of a 4D-imaging system and a novel gene therapy for the hemangioma using nanobubbles and ultrasound

    SAKAMOTO Maya, IIKUBO Masahiro, MORI Shiro, KODAMA Tetsuya, ONO Masao, KOJIMA Ikuho, SASANO Takashi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2009 - 2012

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    The aim of the present study is to develop a diagnostic imaging system and gene therapy system for hemangioma using nanobubbles and ultrasound. In the present study, by using experimental tumor model, we developed a high-resolution diagnostic imaging system utilizing nanobubbles and high-frequency ultrasound image analysis equipment. In addition, we were able to present the possibility of a new gene therapy method for hemangioma by transfer of a plasmid DNA, which inhibited the tumor growth, by utilizing nanobubbles and ultrasound.

  22. ナノバブルを用いたIGF-I長期発現プラスミドによる新たな顎骨再生治療法の開発

    飯久保 正弘, 阪本 真弥, 笹野 高詞, 小嶋 郁穂

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(C)

    Category: 基盤研究(C)

    Institution: 東北大学

    2010 - 2011

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    口腔には顎骨の破壊や吸収を伴う疾患が多く存在し、自家骨や人工骨を用いた再建治療が行われているが、必ずしも満足な結果は得られていない。これまで我々は、「自らが持つ骨形成能による骨再生」を目指し、細胞増殖作用を有するInsulin-like growth factor I(以下IGF-1)に着目した一連の研究を行ってきた。そこで本研究は、IGF-1の骨形成促進作用に着目し、ナノバブルと高周波超音波装置による最新の遺伝子導入システムを用いて、新たな顎骨再生治療を目指すものである。平成23年度において、1)TNF-α発現プラスミドDNAを作製し、ナノバブルと超音波を用いた分子導入法による遺伝子治療実験を行った。その結果、腫瘍の縮小と腫瘍血管の密度の減少が確認でき、この技術をIGF-1の遺伝子導入システムにも応用できるものと思われる。2)IGF-1の全身投与を行なったラットを用いて、エックス線検査を行ない、顎骨、特に歯槽骨に与える影響について検討を行なった。その結果、IGF-1は歯槽骨の海面骨に比べ、皮質骨の骨密度を増加させ、その効果は投与後も持続することが明らかとなった。この結果は、将来の顎骨再生部へのインプラント治療への応用を考えると、非常に有用な情報である。3)顎骨欠損モデルの作製のために、各週齢のラット下顎臼歯抜歯と歯槽骨削除を行なってみた。その結果、ラットは5週齢を越すと抜歯が非常に難しくなることや、抜歯窩の骨形成は4週間ほどで単純エックス線写真においても確認できることが明らかとなった。今後は、この結果をもとに顎骨欠損モデルを作製していくこととする。

  23. An experimental study for a novel gene therapy for the highly malignant tumor of salivary gland using nanobubbles and ultrasound

    SAKAMOTO Maya, IIKUBO Masahiro, MORI Shiro, KODAMA Tetsuya, ONO Masao, KOJIMA Ikuho

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2009 - 2011

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    The aim of the present study is to develop a novel diagnosis and gene therapy system for the highly malignant tumor of salivary gland using nanobubbles and ultrasound. In the present study, by using experimental tumor model, we developed a high-resolution diagnostic imaging system utilizing nanobubbles and high-frequency ultrasound image analysis equipment. In addition, we were able to present the possibility of a new gene therapy method by transfer of a plasmid DNA, which inhibited the tumor growth, by utilizing nanobubbles and ultrasound.

  24. Study of IGF-I effect on anti-aging for the jawbone Competitive

    KOJIMA Ikuho

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2009 - 2011

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    The results of IGF-I administration for normal rat were as follows. 1)Bone mineral density (BMD)analyzed by X-ray photograph increased in lower area of mandibular condyle. 2)On measurement about bone matrix ratio (BMR), BMR was greater in lower part of mandibular condyle (Cd)vertically divided into three parts, and was greater in central part of laterally divided Cd. 3)On measurement about osteoblast, the number of osteoblasts was greater in central and lower parts of vertically divided Cd, and in inside and outside parts of laterally divided Cd. 4)On measurement about osteoclast, the number of osteoclasts has no change in any parts of Cd. 5)These changes during IGF-I administration disappeared after IGF-I administration ended.

  25. セロトニン下行性疼痛制御系の賦活による新たな慢性痛制御理論 Competitive

    庄司憲明, 佐藤しづ子, 小野寺 大, 栗原直之, 小嶋郁穂

    System: 科学研究費補助金

    2008 - 2009

  26. Study of IGF-I effect on anti-aging for the jawbone and masticatory muscles Competitive

    KOJIMA Ikuho

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2007 - 2008

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Social Activities 5

  1. [日本国内] 身元確認、巡回診療

    2011/03/12 - 2011/03/31

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    東日本大震災における身元確認、巡回診療に参加した。

  2. National diagnostic reference levels in Japan (2025)

    2025/07/07 -

  3. GUIDELINE FOR HAND-HELD USE OF PORTABLE INTRAORAL X-RAY EQUIPMENT 2023 revised edition

    2023/04/14 -

  4. Guidline for the Safe Management of Diagnostic Radiation in Dental Clinics

    2020/11 -

  5. National diagnostic reference levels in Japan (2020)

    2020/07/03 -