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Akihiro Kuwahata

Section

Graduate School of Engineering

Job title

Associate Professor

Degree

博士（工学）（東京大学）
修士（工学）（東京大学）

researchmap

https://researchmap.jp/magmagmag

J-GLOBAL ID

201901002584640284

Research History 3

2021/04 - Present

Tohoku University　Graduate School of Engineering Department of Electrical Engineering
2016/04 - 2021/03

The University of Tokyo　The Graduate School of Engineering Department of Electrical Engineering and Information Systems
2014/04 - 2016/03

The University of Tokyo　Graduate School of Frontier Sciences

Education 1

The University of Tokyo

2009/04 - 2014/03

Committee Memberships 5

電気学会生体磁気関連調査専門委員会　幹事

2024/10 - Present
スピニクス研究会　幹事

2024/04 - Present
日本生体磁気学会　評議員

2024/04 - Present
日本磁気学会　編集委員

2019/06 - Present
電気学会　東北支部幹事

2022/05 - 2024/04

Professional Memberships 5

日本生体磁気学会
電気学会
IEEE EMBS
IEEE
日本磁気学会

Research Interests 5

実験室プラズマ
がん診断・がん治療
magnetic nanoparticles
Bioengineering
Biomagnetism

Research Areas 6

Natural sciences / Magnetism, superconductivity, and strongly correlated systems /
Energy / Applied plasma science /
Nanotechnology/Materials / Nanobioscience /
Life sciences / Laboratory animal science /
Life sciences / Medical systems /
Life sciences / Biomedical engineering /

Awards 4

https://www.nature.com/collections/ihggebhehd

2021/03　https://www.nature.com/articles/s41598-020-59064-6
優秀論文発表賞

2016/10　電気学会
若手優秀発表賞

2014/06　核融合エネルギー連合講演会
若手優秀発表賞

2011/11　プラズマ・核融合学会

Papers 81

磁気渦構造を持つ中空構造Fe3O4粒子の磁気加熱特性 Peer-reviewed

秋山遥,Ton That Loi, 桑波田晃弘, 薮上信, 小林悟

T. Magn. Soc. Jpn. (Special Issues)　8　79-83　2024/08
Treatment Temperature and Magnetic Field Distribution for Magnetic Hyperthermia Using Magnetic Nanoparticles Peer-reviewed

Takayuki Kagami, Akihiro Kuwahata, Shin Yabukami

IEEJ Transactions on Electrical and Electronic Engineering　19　(5)　755-758　2024/02/15
Publisher: Wiley
DOI： 10.1002/tee.24013 　

ISSN： 1931-4973

eISSN： 1931-4981

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A minimally invasive cancer treatment method utilizing magnetic nanoparticles (MNPs) and magnetic coils, magnetic hyperthermia, generates heat locally inside the body to degenerate cancer cells. The uniformity of the coil's magnetic field is a crucial factor in enhancing the therapeutic effect. In this study, we evaluated the temperature distribution of MNPs on induction heating experiments at various distances using two types of coils. We found that the 2‐turn coil with a larger outer diameter and higher magnetic field uniformity resulted in a treatment temperature region approximately twice as wide as the 4‐turn coil, indicating the enhancement of the treatment effect under the uniform magnetic field distributions. © 2024 Institute of Electrical Engineer of Japan and Wiley Periodicals LLC.
Optimizing transcranial magnetic stimulator coils for minimal influence of individual variability in head geometry Peer-reviewed

Shuang Liu, Hikaru Yoshioka, Akihiro Kuwahata, Masaki Sekino

AIP Advances　14　(2)　2024/02/01
Publisher: AIP Publishing
DOI： 10.1063/9.0000795 　

eISSN： 2158-3226

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In prior studies focused on transcranial magnetic stimulator (TMS) coils, optimization of coil windings typically occurred on generic curved surfaces, such as planes or cylindrical shapes. However, these surfaces do not consider the challenge of coil misalignment, which arises due to variations in individual head geometries. This misalignment can significantly diminish the coil's effectiveness. To address this issue, we propose a novel coil design approach that identifies the 'best-fit' curved surface, minimizing the likelihood of mismatch with diverse skull geometries. We further enhance the coil winding pattern using the stream function applied to this custom curved surface. Numerical simulations using a hemisphere brain model demonstrate that the coil designed on this 'best-fit' curved surface exhibits a remarkable 22% increase in efficiency and a 41% expansion in stimulation area compared to the conventional butterfly coil. These findings underscore the advantages of our method in crafting high-efficiency and wide-ranging therapeutic TMS coil.
Enhancing heating efficiency of magnetic hyperthermia using pulsed magnetic fields Peer-reviewed

Yuui Adachi, Akihiro Kuwahata, Eiji Nakamura, Shin Yabukami

AIP Advances　14　(1)　2024/01/01
Publisher: AIP Publishing
DOI： 10.1063/9.0000702 　

eISSN： 2158-3226

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We investigated the magnetization response and heat generation of magnetic particles exposed to high-speed pulsed magnetic fields (PMF) during magnetic hyperthermia cancer treatment. The magnetization measurements exhibited an asymmetric change in the shape of the hysteresis loop, attributable to the rapid and substantial changes in the short-duration PMF (75 mT/μs). We propose a novel parameter to evaluate heat efficiency. The parameter considered disparities in waveforms and served as a valuable metric for evaluating the effectiveness of heat production. Our findings affirmed a substantial enhancement in heat efficiency with the application of PMF. Furthermore, the heat generation stemming from the magnetic energy dissipation within the PMF exhibited direct proportionality to the square of the field amplitude. The heat efficiency is fourfold higher than that generated by conventional waveform.
Estimating the location of the hook-wire used in breast-conserving surgery using a magnetometer Peer-reviewed

Oiendrila Bhowmik Debnath, Akihiro Kuwahata, Yuki Sunaga, Shinichi Chikaki, Miki Kaneko, Moriaki Kusakabe, Masaki Sekino

AIP Advances　14　(1)　2024/01/01
Publisher: AIP Publishing
DOI： 10.1063/9.0000799 　

eISSN： 2158-3226

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In the surgical treatment of nonpalpable breast lesions, such as in early-stage cancer, a hook-wire is inserted into the lesion as a marker to enable surgeons to excise the tissue, along with the hook-wire, with a good margin. However, a benchmark technique for intraoperatively determining whether the excised tissue has an appropriate margin around the lesion has not yet been established. In this study, a method for locating a ferromagnetic stainless steel hook-wire inside the excised tissue using a magnetometer is proposed. The magnetometer is placed around a phantom along with the hook-wire at varied locations to map the magnetic field distribution. The three-dimensional coordinates of hook-wire are obtained by executing an optimization algorithm. The experimental results indicate that the location of the hook-wire is successfully obtained. Based on the information regarding the margin around the hook-wire, the surgeon can immediately evaluate the risk of whether some cancer cells still remain in the body.
Ferromagnetic resonance-based heat dissipation in dumbbell-like Au–Fe3O4 nanoparticles Peer-reviewed

Loi Tonthat, Akihiro Kuwahata, Shin Yabukami

AIP Advances　14　(1)　2024/01/01
Publisher: AIP Publishing
DOI： 10.1063/9.0000825 　

eISSN： 2158-3226

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Ferromagnetic resonance (FMR) holds promise for heating magnetic nanoparticles (MNPs) in cancer therapy, especially for rapidly heating MNPs. This study aims to enhance the FMR-based heating efficiency of multifunctional hybrid gold and iron oxide nanoparticles (Au-Fe3O4 NPs) as theranostic agents. We experimentally investigate the FMR-based heating properties of newly developed dumbbell-like Au-Fe3O4 NPs, which feature ∼5 nm gold and 15 nm iron oxide components, in comparison to our previously developed Au-coated Fe3O4 NPs (Fe3O4 core ∼5.2 nm, Au shell thickness ∼0.5 nm). For comparison, we also synthesize pure Fe3O4 NPs (∼11 nm) under the same experimental conditions as the dumbbell-like Au-Fe3O4 NPs but without 5 nm Au seeds. Temperature measurements are taken at various DC fields (HDC = 0‒1600 Oe) under a radiofrequency (RF) field (fAC = 4 GHz, HAC = 1.265 Oe) for ∼13s. The results reveal a rapid temperature rise during RF field ON, followed by a decline upon RF field OFF. Remarkably, dumbbell-like Au-Fe3O4 NPs achieve a peak temperature increase of 23.4 °C, corresponding to a heating rate of 1.73 °C/s at HDC = 400 Oe, surpassing the combined values of ∼11 nm Fe3O4 NPs (11.0 °C, i.e., 0.83 °C/s at HDC = 1000 Oe) and ∼5 nm Au NPs (3.5 °C). Comparing these results to our previously developed Au-coated Fe3O4 NPs, which achieved a heating rate of 1.29 °C/s (temperature rise 16.9 °C) under HDC = 1200 Oe with an RF field at fAC = 4 GHz and a significantly higher HAC = 4 Oe (i.e. for HAC = 1.265 Oe, the estimated heating rate was 0.129 °C/s with a temperature rise of 1.69 °C), the dumbbell-shaped Au-Fe3O4 NPs demonstrate a substantially higher temperature increase by 13.4 times. These findings highlight the exceptional potential of dumbbell-shaped Au-Fe3O4 NPs for application in magnetic hyperthermia.
MRI Pulse Sequence for Quantifying Magnetic Nanoparticles from Highly Distorted Static Field: View Line Peer-reviewed

Shuang Liu, Wenqi Qiu, Gabriel Della Maggiora, Akihiro Kuwahata, Pablo Irarrazaval, Masaki Sekino

IEEE Transactions on Magnetics　1-1　2024
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
DOI： 10.1109/tmag.2024.3426948 　

ISSN： 0018-9464

eISSN： 1941-0069
Feasibility study on on-board magnetoencephalography with optically pumped magnetometers Peer-reviewed

Xinyu Cao, Motofumi Fushimi, Shinichi Chikaki, Akihiro Kuwahata, Masaki Sekino

AIP Advances　14　(1)　2024/01/01
Publisher: AIP Publishing
DOI： 10.1063/9.0000694 　

eISSN： 2158-3226

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In this study, the theoretical feasibility of utilizing optically pumped magnetometers for on-board magnetoencephalography measurements was explored. Simulations were conducted to generate steady-state visually evoked response (SSVER) signals that incorporate vehicle noise, and a noise reduction strategy specifically designed for on-board applications is proposed. Upon engine activation, the magnetic field vibration of a conventional gasoline-powered vehicle measured in an urban environment was found to be approximately seven times greater in the vertical direction than in the horizontal direction. The maximum signal-to-noise ratio of the SSVER in an automotive environment was simulated to be −110 dB. A 350-mm side-length, 20-turn active compensation coil can achieve an attenuation rate of approximately 28 dB at a target frequency of 24 Hz for measurements inside the vehicle cabin. Therefore, an increase in the number of coil turns would result in a higher attenuation rate. Further noise attenuation to the level inside a magnetically shielded room requires approximately 80 dB.
Surface receive coil dedicated for rat kidney with high sensitivity magnetic resonance imaging

Masaharu Takahashi, Motofumi Fushimi, Shin Yabukami, Masaki Sekino, Akihiro Kuwahata

AIP Advances　14　(1)　2024/01/01
Publisher: AIP Publishing
DOI： 10.1063/9.0000733 　

eISSN： 2158-3226

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We propose a novel method based on an inverse problem to design a single channel radio frequency (RF) receive coil for magnetic resonance imaging (MRI) with an optimized signal-to-noise ratio (SNR) for imaging the rat kidney. We identified a dedicated curved-surface coil design for use on the rat body surface utilizing inverse problem analysis using direct current calculation and quantitatively evaluated the indicators of coil performance using alternating current calculation. The proposed coil achieved increased SNR and signal intensity responses that were respectively 1.05- and 2-fold higher than those of conventional surface coils. In the future, we will fabricate a prototype coil and perform the MRI of the rat kidney to diagnose kidney diseases.
Localization of a Ferromagnetic Marker Being Magnetized by a Magnetic Probe Equipped With a Permanent Magnet

Yoshihiko Inoue, Motofumi Fushimi, Shinichi Chikaki, Yingyi Xiao, Akihiro Kuwahata, Moriaki Kusakabe, Masaki Sekino

IEEE Transactions on Magnetics　59　(11)　1-5　2023/11
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
DOI： 10.1109/tmag.2023.3283243 　

ISSN： 0018-9464

eISSN： 1941-0069
Brain Response to Interferential Current Compared with Alternating Current Stimulation International-journal

Zonghao Xin, Yoshifumi Abe, Akihiro Kuwahata, Kenji F. Tanaka, Masaki Sekino

Brain Sciences　13　(9)　2023/09

DOI： 10.3390/brainsci13091317 　

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Temporal interference (TI) stimulation, which utilizes multiple external electric fields with amplitude modulation for neural modulation, has emerged as a potential noninvasive brain stimulation methodology. However, the clinical application of TI stimulation is inhibited by its uncertain fundamental mechanisms, and research has previously been restricted to numerical simulations and immunohistology without considering the acute in vivo response of the neural circuit. To address the characterization and understanding of the mechanisms underlying the approach, we investigated instantaneous brainwide activation patterns in response to invasive interferential current (IFC) stimulation compared with low-frequency alternative current stimulation (ACS). Results demonstrated that IFC stimulation is capable of inducing regional neural responses and modulating brain networks; however, the activation threshold for significantly recruiting a neural response using IFC was higher (at least twofold) than stimulation via alternating current, and the spatial distribution of the activation signal was restricted. A distinct blood oxygenation level-dependent (BOLD) response pattern was observed, which could be accounted for by the activation of distinct types of cells, such as inhibitory cells, by IFC. These results suggest that IFC stimulation might not be as efficient as conventional brain modulation methods, especially when considering TI stimulation as a potential alternative for stimulating subcortical brain areas. Therefore, we argue that a future transcranial application of TI on human subjects should take these implications into account and consider other stimulation effects using this technique.
Ultrafast Heating Rate of Ultrasmall Gold-coated Iron Oxide Magnetic Nanoparticles by Ferromagnetic Resonance

Loi Tonthat, Akihiro Kuwahata, Tomoyuki Ogawa, Shin Yabukami

2023 IEEE International Magnetic Conference - Short Papers (INTERMAG Short Papers)　2023/05
Publisher: IEEE
DOI： 10.1109/intermagshortpapers58606.2023.10228356 　
研究グループ紹介：東北大学大学院医工学研究科・工学研究科薮上・桑波田研究室

Ton That Loi, 晃弘桑波田, 信薮上

IEEJ Transactions on Fundamentals and Materials　143　(4)　NL4_4-NL4_4　2023/04/01
Publisher: Institute of Electrical Engineers of Japan (IEE Japan)
DOI： 10.1541/ieejfms.143.nl4_4 　

ISSN： 0385-4205

eISSN： 1347-5533
Rapid virus detection using magnetic second harmonics of superparamagnetic iron oxide nanoparticles Peer-reviewed

Ryuichi Hirota, Toru Murayama, Ryota Katsumi, Tokuhisa Kawawaki, Shin Yabukami, Ryuji Igarashi, Yuichi Negishi, Moriaki Kusakabe, Masaki Sekino, Takashi Yatsui, Akihiro Kuwahata

AIP Advances　13　(2)　025144-025144　2023/02/01
Publisher: AIP Publishing
DOI： 10.1063/9.0000483 　

eISSN： 2158-3226

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Virus detection methods based on nonlinear magnetic response of magnetic nanoparticles have been investigated, and magnetic detection methods using the third harmonic are widely applied, owing to their high sensitivity and short measurement time. This paper proposes a virus detection method based on the second harmonic because of its larger signal component. We found that the second harmonic signal is superior to the third harmonic signal for small nanobeads and a large change of the second harmonic signal in the signal-to-noise ratio (SNR) with nanobeads concentration. In addition, a virus detection limit of 100 pg/ml is achieved. Therefore, the proposed method can potentially be utilized for rapid screening of viruses.
Wireless temperature monitoring by using magnetic nanoparticles for biomedical applications on magnetic hyperthermia treatment

Akihiro Kuwahata, Ryuichi Hirota, Ariunbuyan Sukhbaatar, Tetsuya Kodama, Shin Yabukami

AIP Advances　13　(2)　025142-025142　2023/02/01
Publisher: AIP Publishing
DOI： 10.1063/9.0000557 　

eISSN： 2158-3226

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Magnetic hyperthermia with magnetic nanoparticles (MNPs) has been introduced to selective treatment of tumor and the MNPs also has demonstrated diagnosis. For non-invasive treatment, a therapeutic platform with temperature monitoring that can avoid overheating in normal tissues is of vital importance. In this study, we have developed a wireless temperature monitoring system by utilizing the combination of magnetic harmonic signals of the MNPs for magnetic hyperthermia treatment in laboratory experiments. We achieved an accurate measurement with an error of 0.18 °C. For practical use on breast/oral cancer, a detectable distance of at least 10 mm is required. To demonstrate the feasibility toward future biomedical applications, we investigated the dependency on the amount of Resovist^® and the error is less than 0.5 °C in a 10 mm distance. Our system can measure the correct temperature regardless of Resovist amount. The results indicate that our system can apply for monitoring temperature on magnetic hyperthermia treatment.
Heating of Magnetic Particles by Application of High Frequency Pulsed Magnetic Field

安達友威, 桑波田晃弘, 薮上信, 薮上信, 中村英滋, 中村英滋

日本磁気学会論文特集号(Web)　7　(1)　102-107　2023
Publisher: The Magnetics Society of Japan
DOI： 10.20819/msjtmsj.23TR519 　

ISSN： 2432-0471

eISSN： 2432-0471

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We analyzed a circuit for generating a pulsed magnetic field with a pulse width of 2 μs at 250 kHz using circuit simulation. We developed a circuit that can generate a 12A, 250kHz pulsed current. Next, we conducted heating experiments with small magnetic particles for 200 s using the pulsed magnetic field, and the advantage of the field was 15 times that of a sine wave magnetic field with respect to magnetic energy. This study has the potential to improve the heating efficiency of magnetic hyperthermia, to reduce the amount of magnetic material, and to treat deep inside the body.
Ferromagnetic resonance heating of magnetic nanoparticles Resovist for biomedical applications

Akihiro Kuwahata, Weronika Szawro, Takayuki Kagami, Masaharu Takahashi, Shin Yabukami

IEEE Transactions on Magnetics　1-1　2023
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
DOI： 10.1109/tmag.2023.3285234 　

ISSN： 0018-9464

eISSN： 1941-0069
Transfer-printing-based integration of silicon nitride grating structure on single-crystal diamond toward sensitive magnetometers

Ryota Katsumi, Takeshi Hizawa, Akihiro Kuwahata, Shun Naruse, Yuji Hatano, Takayuki Iwasaki, Mutsuko Hatano, Fedor Jelezko, Shinobu Onoda, Takeshi Ohshima, Masaki Sekino, Takashi Yatsui

Applied Physics Letters　121　(16)　161103-161103　2022/10/17
Publisher: AIP Publishing
DOI： 10.1063/5.0107854 　

ISSN： 0003-6951

eISSN： 1077-3118

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Negatively charged nitrogen-vacancy (NV) centers in diamond have emerged as promising candidates for a wide range of quantum applications, especially quantum sensing of magnetic field. Implementation of nanostructure into diamond is powerful for efficient photon collection of NV centers and chip-scale miniaturization of the device, which is crucial for sensitive and practical diamond magnetometers. However, fabrication of the diamond nanostructure involves technical limitations and can degrade the spin coherence of the NV centers. In this study, we demonstrate the hybrid integration of a silicon nitride grating structure on a single-crystal diamond by utilizing transfer printing. This approach allows the implementation of the nanostructure in diamond using a simple pick-and-place assembly, facilitating diamond-based quantum applications without any complicated diamond nanofabrication. We observed the intensity enhancement in the collected NV emissions both theoretically and experimentally using the integrated grating structure. By applying the increased photon intensity, we demonstrate the improved magnetic sensitivity of the fabricated device. The proposed hybrid integration approach will offer a promising route toward a compact and sensitive diamond NV-based magnetometer.
Millimetre-scale magnetocardiography of living rats with thoracotomy

Keigo Arai, Akihiro Kuwahata, Daisuke Nishitani, Ikuya Fujisaki, Ryoma Matsuki, Yuki Nishio, Zonghao Xin, Xinyu Cao, Yuji Hatano, Shinobu Onoda, Chikara Shinei, Masashi Miyakawa, Takashi Taniguchi, Masatoshi Yamazaki, Tokuyuki Teraji, Takeshi Ohshima, Mutsuko Hatano, Masaki Sekino, Takayuki Iwasaki

Communications Physics　5　(1)　200　2022/08/23
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s42005-022-00978-0 　

eISSN： 2399-3650

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Abstract Magnetocardiography is a contactless imaging modality for electric current propagation in the cardiovascular system. Although conventional sensors provide sufficiently high sensitivity, their spatial resolution is limited to a centimetre-scale, which is inadequate for revealing the intra-cardiac electrodynamics such as rotational waves associated with ventricular arrhythmias. Here, we demonstrate invasive magnetocardiography of living rats at a millimetre-scale using a quantum sensor based on nitrogen-vacancy centres in diamond. The acquired magnetic images indicate that the cardiac signal source is well explained by vertically distributed current dipoles, pointing from the right atrium base via the Purkinje fibre bundle to the left ventricular apex. We also find that this observation is consistent with and complementary to an alternative picture of electric current density distribution calculated with a stream function method. Our technique will enable the study of the origin and progression of various cardiac arrhythmias, including flutter, fibrillation, and tachycardia.
Application of Magnetic Nanoparticle in Cancer Surgery—Sentinel Node Mapping and Magnetically Promoted Rapid Immunofluorescence Staining—

Mihara Kisyo, Onishi Tatsuya, Matsuda Sachiko, Sakamoto Satoshi, Handa Hiroshi, Kuwahata Akihiro, Sekino Masaki, Kusakabe Moriaki, Kitagawa Yuko

IEEJ Transactions on Fundamentals and Materials　142　(6)　236-242　2022/06/01
Publisher: The Institute of Electrical Engineers of Japan
DOI： 10.1541/ieejfms.142.236 　

ISSN： 0385-4205

eISSN： 1347-5533

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Recently, there has been remarkable progress in the field of magnetic nanoparticles, with them now being applied in cancer surgery. During tumor surgery, lymph node dissection is required along with tumor resection. However, in cases such as breast cancer, lymph node dissection can be omitted if no metastasis is found in the sentinel lymph node (SLN; the first draining lymph node from a primary tumor), thereby reducing postoperative sequelae. The presence or absence of SN metastasis alters the surgical procedure; therefore, intraoperative SLN mapping and rapid pathological SLN diagnosis are required. The standard procedure of SLN mapping is a combination of radioisotope and dye methods, but radioisotope methods have problems associated with regulation and safety. To overcome these problems, a SLN mapping method using magnetic nanoparticles has been developed. This technique has already been clinically applied to breast cancer. In this article, a laparoscopic magnetic probe was developed to expand the SLN theory to visceral organs such as the stomach and gallbladder. A preclinical study of SLN mapping was feasible in laparoscopic minimally invasive surgery. Although resected sentinel lymph nodes can be rapidly diagnosed intraoperatively, the diagnostic accuracy of hematoxylin and eosin staining is limited. Conversely, immunohistochemistry, which gives additional information to pathologists by staining particular proteins, has not yet been used for rapid diagnostics because of the time required for staining. A new rapid immunostaining method is magnetically-promoted rapid immunofluorescence staining using functionalized fluorescent ferrite beads. The antigen-antibody reaction is accelerated by magnetic force, and antigen-antibody complexes can be directly observed with a fluorescence microscope. We have succeeded in diagnosing frozen sections within 15 min from fixation to staining. To realize minimally invasive surgery, a detailed understanding of tumor development is essential, and nanotechnology is being applied in this field to address this issue. In this paper, we introduce a SLN biopsy and rapid immunostaining method based on magnetic nanoparticle technology to further this field.
Virus Detection using Second Harmonics of Magnetic Nanoparticles

Ryuichi Hirota, Toru Murayama, Ryota Katsumi, Tokuhisa Kawawaki, Shin Yabukami, Ryuji Igarashi, Yuichi Negishi, Moriaki Kusakabe, Masaki Sekino, Takashi Yatsui, Akihiro Kuwahata

IEEJ Transactions on Electrical and Electronic Engineering　17　(8)　1228-1230　2022/04/12
Publisher: Wiley
DOI： 10.1002/tee.23613 　

ISSN： 1931-4973

eISSN： 1931-4981
Application of Magnetic Nanoparticles for Rapid Detection and In Situ Diagnosis in Clinical Oncology. International-journal

Tatsuya Onishi, Kisyo Mihara, Sachiko Matsuda, Satoshi Sakamoto, Akihiro Kuwahata, Masaki Sekino, Moriaki Kusakabe, Hiroshi Handa, Yuko Kitagawa

Cancers　14　(2)　2022/01/12

DOI： 10.3390/cancers14020364 　

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Screening, monitoring, and diagnosis are critical in oncology treatment. However, there are limitations with the current clinical methods, notably the time, cost, and special facilities required for radioisotope-based methods. An alternative approach, which uses magnetic beads, offers faster analyses with safer materials over a wide range of oncological applications. Magnetic beads have been used to detect extracellular vesicles (EVs) in the serum of pancreatic cancer patients with statistically different EV levels in preoperative, postoperative, and negative control samples. By incorporating fluorescence, magnetic beads have been used to quantitatively measure prostate-specific antigen (PSA), a prostate cancer biomarker, which is sensitive enough even at levels found in healthy patients. Immunostaining has also been incorporated with magnetic beads and compared with conventional immunohistochemical methods to detect lesions; the results suggest that immunostained magnetic beads could be used for pathological diagnosis during surgery. Furthermore, magnetic nanoparticles, such as superparamagnetic iron oxide nanoparticles (SPIONs), can detect sentinel lymph nodes in breast cancer in a clinical setting, as well as those in gallbladder cancer in animal models, in a surgery-applicable timeframe. Ultimately, recent research into the applications of magnetic beads in oncology suggests that the screening, monitoring, and diagnosis of cancers could be improved and made more accessible through the adoption of this technology.
Application of Magnetic Nanoparticles for Rapid Detection and In Situ Diagnosis in Clinical Oncology Peer-reviewed

Tatsuya Onishi, Kisyo Mihara, Sachiko Matsuda, Satoshi Sakamoto, Akihiro Kuwahata, Masaki Sekino, Moriaki Kusakabe, Hiroshi Handa, Yuko Kitagawa

Cancers　14　(2)　364-364　2022/01/12

DOI： 10.3390/cancers14020364 　

ISSN： 1552-4450

eISSN： 2072-6694
Sentinel lymph node biopsy with a handheld cordless magnetic probe following preoperative MR lymphography using superparamagnetic iron oxide for clinically N0 early oral cancer: A feasibility study. International-journal

Satomi Sugiyama, Toshinori Iwai, Junichi Baba, Senri Oguri, Toshiharu Izumi, Akihiro Kuwahata, Masaki Sekino, Moriaki Kusakabe, Kenji Mitsudo

Journal of stomatology, oral and maxillofacial surgery　123　(5)　521-526　2022/01/08
Publisher:
DOI： 10.1016/j.jormas.2022.01.003 　

ISSN： 2468-7855

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PURPOSE: Radioisotope (RI) tracers are generally used for preoperative mapping of sentinel lymph node (SLN) and intraoperative detection with a portable γ probe. However, the use of RI has several limitations. Therefore, a method without RI is required for the widespread application of SLN biopsy. The purpose of this study was to evaluate the feasibility of SLN biopsy with a handheld cordless magnetic probe following magnetic resonance lymphography (MRL) using superparamagnetic iron oxide (SPIO) and for clinically N0 early oral cancer. MATERIALS AND METHODS: MRL using SPIO and SLNB with the handheld cordless magnetic probe were performed for 27 patients with clinically N0 early oral cancer. RESULTS: In all 27 patients (100%), SLNs were detected by MRL, and the total and mean number of SLNs were 73 and 2.7, respectively. All SLNs identified by MRL were detectable using the magnetic probe in all patients. CONCLUSIONS: SLNB with handheld cordless magnetic probe following preoperative SLN mapping by MRL using SPIO is feasible, without RI use, for neck management in cases of clinically N0 early oral cancer.
Animal Experiment of PID-based Automatic Temperature Control System for Magnetic Hyperthermia. Peer-reviewed

Shikano A, Tonthat L, Kuwahata A, Sukhbaatar A, Kodama T, Yabukami S

T. Magn. Soc. Jpn. (Special Issues)　6　(1)　100-104　2022
Publisher: The Magnetics Society of Japan
DOI： 10.20819/msjtmsj.22TR519 　

ISSN： 2432-0471

eISSN： 2432-0471

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Magnetic hyperthermia (MH) is a promising cancer therapy in which the heating temperature is expected to be a key determinant for its success. A therapeutic system with high-accuracy temperature control is of vital importance to avoid overheating in normal tissues surrounding a tumor. We previously developed a PID-based temperature control system and verified its validity in vitro. In this study, we validate our control system in vivo. First, we investigated both the improvement in heat generation by high-density Resovist^® (Ferucarbotran) and the optimal PID tuning method for the high-density Resovist^® in vitro. Next, we injected the high-density Resovist^® into mice and then performed PID-based temperature control in vivo. We demonstrate that by using our PID-based control system, it is possible to accurately control the therapeutic temperature (e.g., 50°C) in vivo with a standard deviation of 0.05°C in the steady-state. Our system has the potential to be used for MH either alone or together with other cancer treatment modalities for basic and clinical studies.
Simplified fabrication of magnetic nanoparticles with directly adsorbed antibodies for bacteria detection

Tsuyoshi Yoneyama, Akihiro Kuwahata, Toru Murayama, Loi Tonthat, Shin Yabukami, Yuya Sato, Yuji Teramura, Wakako Ikeda-Ohtsubo, Tomoyuki Ogawa

IEEE Transactions on Magnetics　58　(8)　1-1　2022
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
DOI： 10.1109/tmag.2022.3168360 　

ISSN： 0018-9464

eISSN： 1941-0069
Magnetically Induced Temporal Interference for Focal and Deep-Brain Stimulation International-journal

Zonghao Xin, Akihiro Kuwahata, Shuang Liu, Masaki Sekino

Frontiers in Human Neuroscience　15　(MAG-21-026-042/MBE-21-018-034)　693207-693207　2021/09/27
Publisher: Frontiers Media S.A.
DOI： 10.3389/fnhum.2021.693207 　

ISSN： 1662-5161
健常犬におけるFerahemeを用いたセンチネルリンパ節磁気プローブ検出法と頭頸部リンパ節マッピングの有用性

山本貴恵, 池田凡子, 桑波田晃弘, 李捷生, 劉爽, 加藤大貴, 斎藤逸郎, 佐伯亘平, 藤田直己, 西村亮平, 関野正樹, 日下部守昭, 中川貴之

日本獣医学会学術集会講演要旨集　164回　[HSO-15]　2021/09
Publisher: (公社)日本獣医学会
ISSN： 1347-8621
Coherent detection stochastic resonance assisted biomagnetometer for measuring magnetocardiography at room temperature

Zhiqiang Liao, Shixu Jin, Akihiro Kuwahata, Masaki Sekino, Hitoshi Tabata

Applied Physics Express　14　(9)　097001-097001　2021/09/01
Publisher: IOP Publishing
DOI： 10.35848/1882-0786/ac1de5 　

ISSN： 1882-0778

eISSN： 1882-0786
All-Optical Wide-Field Selective Imaging of Fluorescent Nanodiamonds in Cells, In Vivo and Ex Vivo International-journal Peer-reviewed

Tamami Yanagi, Kiichi Kaminaga, Michiyo Suzuki, Hiroshi Abe, Hiroki Yamamoto, Takeshi Ohshima, Akihiro Kuwahata, Masaki Sekino, Tatsuhiko Imaoka, Shizuko Kakinuma, Takuma Sugi, Wataru Kada, Osamu Hanaizumi, Ryuji Igarashi

ACS Nano　15　(8)　12869-12879　2021/08/24
Publisher: American Chemical Society (ACS)
DOI： 10.1021/acsnano.0c07740 　

ISSN： 1936-0851

eISSN： 1936-086X

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Fluorescence imaging is a critical tool to understand the spatial distribution of biomacromolecules in cells and in vivo, providing information on molecular dynamics and interactions. Numerous valuable insights into biological systems have been provided by the specific detection of various molecular species. However, molecule-selective detection is often hampered by background fluorescence, such as cell autofluorescence and fluorescence leakage from molecules stained by other dyes. Here we describe a method for all-optical selective imaging of fluorescent nanodiamonds containing nitrogen-vacancy centers (NVCs) for wide-field fluorescence bioimaging. The method is based on the fact that the fluorescence intensity of NVCs strictly depends on the configuration of ground-state electron spins, which can be controlled by changing the pulse recurrence intervals of microsecond excitation laser pulses. Therefore, by using regulated laser pulses, we can oscillate the fluorescence from NVCs in a nanodiamond, while oscillating other optical signals in the opposite phase to NVCs. As a result, we can reconstruct a selective image of a nanodiamond by using a series of oscillated fluorescence images. We demonstrate application of the method to the selective imaging of nanodiamonds in live cells, in microanimals, and on a hippocampal slice culture obtained from a rat. Our approach potentially enables us to achieve high-contrast images of nanodiamond-labeled biomolecules with a signal-to-background ratio improved by up to 100-fold over the standard fluorescence image, thereby providing a more powerful tool for the investigation of molecular dynamics in cells and in vivo.
Magnetically guided localization using a guiding-marker system® and a handheld magnetic probe for nonpalpable breast lesions: A multicenter feasibility study in japan International-journal Peer-reviewed

Tomoko Kurita, Kanae Taruno, Seigo Nakamura, Hiroyuki Takei, Katsutoshi Enokido, Takashi Kuwayama, Yoko Kanada, Sadako Akashi-Tanaka, Misaki Matsuyanagi, Meishi Hankyo, Keiko Yanagihara, Takashi Sakatani, Kentaro Sakamaki, Akihiro Kuwahata, Masaki Sekino, Moriaki Kusakabe

Cancers　13　(12)　2923　2021/06/02
Publisher:
DOI： 10.3390/cancers13122923 　

eISSN： 2072-6694
Millimetre-scale magnetocardiography of living rats using a solid-state quantum sensor

Keigo Arai, Akihiro Kuwahata, Daisuke Nishitani, Ikuya Fujisaki, Ryoma Matsuki, Zhonghao Xin, Yuki Nishio, Xinyu Cao, Yuji Hatano, Shinobu Onoda, Chikara Shinei, Masashi Miyakawa, Takashi Taniguchi, Masatoshi Yamazaki, Tokuyuki Teraji, Takeshi Ohshima, Mutsuko Hatano, Masaki Sekino, Takayuki Iwasaki

応用物理学会秋季学術講演会講演予稿集(CD-ROM)　82nd　2021/05/25

ISSN： 2758-4704

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A key challenge in cardiology is the non-invasive imaging of electric current propagation occurring in the cardiovascular system at an intra-cardiac scale. A promising approach for directly mapping the current dynamics is to monitor the associated stray magnetic field. However, in this magnetic field approach, the spatial resolution deteriorates significantly as the standoff distance between the target and the sensor increases. Existing sensors usually remain relatively far from the target and provide only centimetre-scale resolution because their operating temperature is not biocompatible. Here we demonstrate millimetre-scale magnetocardiography of living rats using a solid-state quantum sensor based on nitrogen-vacancy centres in diamond. The essence of the method is a millimetre proximity from the sensor to heart surface, which enhances the cardiac magnetic field to greater than nanoteslas and allows the mapping of these signals with intra-cardiac resolution. From the acquired magnetic images, we also estimate the source electric current vector, flowing from the right atria base via the Purkinje fibre bundle to the left ventricular apex. Our results establish the solid-state quantum sensor's capability to probe cardiac magnetic signals from mammalian animals and reveal their intra-cardiac electrodynamics. This technique will enable the study of the origin and progression of myriad cardiac arrhythmias including flutter, fibrillation, and tachycardia.
乳がん治療の最前線磁性体と磁気プローブを用いたピンポイント乳がん手術

栗田智子, 垂野香苗, 中村清吾, 武井寛幸, 榎戸克年, 桑山隆志, 金田陽子, 明石定子, 松柳美咲, 范姜明志, 柳原恵子, 坂谷貴司, 桑波田晃弘, 関野正樹, 日下部守昭

日本外科系連合学会誌　46　(3)　370-370　2021/05
Publisher: 日本外科系連合学会
ISSN： 0385-7883

eISSN： 1882-9112
乳がん治療の最前線磁性体と磁気プローブを用いたピンポイント乳がん手術

栗田智子, 垂野香苗, 中村清吾, 武井寛幸, 榎戸克年, 桑山隆志, 金田陽子, 明石定子, 松柳美咲, 范姜明志, 柳原恵子, 坂谷貴司, 桑波田晃弘, 関野正樹, 日下部守昭

日本外科系連合学会誌　46　(3)　370-370　2021/05
Publisher: 日本外科系連合学会
ISSN： 0385-7883

eISSN： 1882-9112
Intraoperative laparoscopic detection of sentinel lymph nodes with indocyanine green and superparamagnetic iron oxide in a swine gallbladder cancer model International-journal

Kisyo Mihara, Sachiko Matsuda, Yuki Nakamura, Koichi Aiura, Akihiro Kuwahata, Shinichi Chikaki, Masaki Sekino, Moriaki Kusakabe, Shunichi Suzuki, Daiichiro Fuchimoto, Akira Onishi, Junko Kuramoto, Kaori Kameyama, Osamu Itano, Hiroshi Yagi, Yuta Abe, Minoru Kitago, Masahiro Shinoda, Yuko Kitagawa, Bing Xu

PLOS ONE　16　(3)　e0248531　2021/03

DOI： 10.1371/journal.pone.0248531 　

ISSN： 1932-6203

eISSN： 1932-6203
Magnetic Field Generation System of the Magnetic Probe with Diamond Quantum Sensor and Ferromagnetic Materials for the Detection of Sentinel Lymph Nodes with Magnetic Nanoparticles Peer-reviewed

Takahiro Kitaizumi, Akihiro Kuwahata, Kota Saichi, Takumi Sato, Ryuji Igarashi, Takeshi Ohshima, Yuta Masuyama, Takayuki Iwasaki, Mutsuko Hatano, Fedor Jelezko, Moriaki Kusakabe, Takashi Yatsui, Masaki Sekino

IEEE Transactions on Magnetics　57　(2)　1-5　2021/02
Publisher:
DOI： 10.1109/TMAG.2020.3009334 　

ISSN： 0018-9464

eISSN： 1941-0069
Magnetic Nanoparticle Detection by Utilizing Nonlinear Magnetization for Sentinel Lymph Nodes of Breast Cancer Patients Peer-reviewed

Akihiro Kuwahata, Kanae Taruno, Tomoko Kurita, Masujiro Makita, Shinichi Chikaki, Itsuro Saito, Hiroyuki Takei, Seigo Nakamura, Moriaki Kusakabe, Masaki Sekino

IEEE Transactions on Magnetics　57　(2)　1-4　2021/02

DOI： 10.1109/TMAG.2020.3010641 　

ISSN： 0018-9464

eISSN： 1941-0069
Numerical and Experimental Evaluation of Magnetic Markers for Localized Tumor Excision With a Handheld Magnetic Probe

Yingyi Xiao, Oiendrila Bhowmik Debnath, Shinichi Chikaki, Akihiro Kuwahata, Mirjam Peek, Itsuro Saito, Shinsaku Maeda, Moriaki Kusakabe, Masaki Sekino

IEEE TRANSACTIONS ON MAGNETICS　57　(2)　31-35　2021/02

DOI： 10.1109/TMAG.2020.3015853 　

ISSN： 0018-9464

eISSN： 1941-0069
国内発の新規磁気プローブ開発における新しい乳癌手術手法開発取り組みと乳腺外科医の関わり

垂野香苗, 栗田智子, 桑波田晃弘, 柳原恵子, 榎戸克年, 斎藤逸郎, 中川貴之, 斎藤逸郎, 中村清吾, 武井寛幸, 関野正樹, 日下部守昭

日本外科学会定期学術集会抄録集　120回　SF-7　2020/08
Publisher: (一社)日本外科学会
Identification of Metal-Binding Peptides and Their Conjugation onto Nanoparticles of Superparamagnetic Iron Oxides and Liposomes International-journal Peer-reviewed

Tomonobu Kodama, Akifumi Yoshihara, Isha Goel, Masaki Sekino, Akihiro Kuwahata, Atsushi Yoshimori, Yuichi Murayama, Kazuhiko Ishihara, Kristina N. Ekdahl, Bo Nilsson, Yuji Teramura

ACS APPLIED MATERIALS & INTERFACES　12　(22)　24623-24634　2020/06

DOI： 10.1021/acsami.0c06138 　

ISSN： 1944-8244

eISSN： 1944-8252
Fabrication of and Investigation on Grating coupler for the Improvement of Light Extraction Efficiency of Magnetometer with Nitrogen-Vacancy Center in Diamond

Sato Takumi, Kitaizumi Takahiro, Saichi Kota, Kuwahata Akihiro, Igarashi Ryuji, Ohshima Takeshi, Masuyama Yuta, Iwasaki Takayuki, Hating Mutsuko, Making Toshiharu, Yamasaki Satoshi, Jelezko Fedor, Kusakabe Moriaki, Sekino Masaki, Yatsui Takashi

JSAP Annual Meetings Extended Abstracts　2020.1　723-723　2020/02/28
Publisher: The Japan Society of Applied Physics
DOI： 10.11470/jsapmeeting.2020.1.0_723 　

ISSN： 2436-7613

eISSN： 2436-7613
Development of Magnetic Probe for Sentinel Lymph Node Detection in Laparoscopic Navigation for Gastric Cancer Patients International-journal Peer-reviewed

Akihiro Kuwahata, Ryo Tanaka, Sachiko Matsuda, En Amada, Tomoyuki Irino, Shuhei Mayanagi, Shinichi Chikaki, Itsuro Saito, Norio Tanabe, Hirofumi Kawakubo, Hiroya Takeuchi, Yuko Kitagawa, Moriaki Kusakabe, Masaki Sekino

SCIENTIFIC REPORTS　10　(1)　1798-1798　2020/02

DOI： 10.1038/s41598-020-58530-5 　

ISSN： 2045-2322

eISSN： 2045-2322
Magnetometer with nitrogen-vacancy center in a bulk diamond for detecting magnetic nanoparticles in biomedical applications International-journal Peer-reviewed

Akihiro Kuwahata, Takahiro Kitaizumi, Kota Saichi, Takumi Sato, Ryuji Igarashi, Takeshi Ohshima, Yuta Masuyama, Takayuki Iwasaki, Mutsuko Hatano, Fedor Jelezko, Moriaki Kusakabe, Takashi Yatsui, Masaki Sekino

SCIENTIFIC REPORTS　10　(1)　2483-2483　2020/02

DOI： 10.1038/s41598-020-59064-6 　

ISSN： 2045-2322

eISSN： 2045-2322
Development of an optimized dome-shaped magnet for rapid magnetic immunostaining Peer-reviewed

Masaki Sekino, Akihiro Kuwahata, Shunsuke Fujita, Sachiko Matsuda, Miki Kaneko, Shinichi Chikaki, Satoshi Sakamoto, Itsuro Saito, Hiroshi Handa, Moriaki Kusakabe

AIP ADVANCES　10　(2)　2020/02

DOI： 10.1063/1.5130516 　

eISSN： 2158-3226
Magnetic nanoparticle detection in lymph nodes of breast cancer patients for cancer diagnosis

Kuwahata Akihiro, Sekino Masaki, Taruno Kanae, Kurita Tomoko, Makita Masujiro, Chikaki Shinichi, Saito Itsuro, Takei Hiroyuki, Nakamura Seigo, Kusakabe Moriaki

Transactions of Japanese Society for Medical and Biological Engineering　58　(0)　284-284　2020
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.Annual58.284 　

ISSN： 1347-443X

eISSN： 1881-4379

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The quantitative detection of the magnetic nanoparticles (MNPs) in sentinel lymph nodes (SLNs) can help to diagnose cancer metastasis for breast cancer patients because the SLN (i.e., 1st SLN) containing the largest amount of the MNPs has the metastasis with the highest probability. In this study, we have optimized the frequency of alternating current (AC) magnetic fields under the application of direct current (DC) magnetic fields to achieve the highly-sensitive detection, and demonstrated the intraoperative detection of the MNPs accumulated into the SLNs to reduce the injection amount. Considering the noise signal and hysteresis loss, AC fields with 2-5 kHz was effective for the detection. The clinical trials with breast cancer patients, for the MNP detection using a developed device, revealed that the MNP amount of 1st SLN was ~40 ug. We will pursue the further detailed magnetic characteristics of the device and the MNPs for biomedical applications.
Cavity-shaped magnet for highly sensitive magnetic detection of magnetic nanoparticles in breast cancer patients Peer-reviewed

Akihiro Kuwahata, Moriaki Kusakabe, Shinichi Chikaki, Itsuro Saito, Masaki Sekino

AIP ADVANCES　10　(1)　2020/01

DOI： 10.1063/1.5130434 　

eISSN： 2158-3226
Moving a neodymium magnet promotes the migration of a magnetic tracer and increases the monitoring counts on the skin surface of sentinel lymph nodes in breast cancer. International-journal Peer-reviewed

Masujiro Makita, Eriko Manabe, Tomoko Kurita, Hiroyuki Takei, Seigo Nakamura, Akihiro Kuwahata, Masaki Sekino, Moriaki Kusakabe, Yasuo Ohashi

BMC Medical Imaging　20　(1)　58-58　2020

DOI： 10.1186/s12880-020-00459-2 　

ISSN： 1471-2342

eISSN： 1471-2342
Development of an automatic magnetic immunostaining system for rapid intraoperative diagnosis of cancer metastasis Peer-reviewed

Masaki Sekino, Akihiro Kuwahata, Akinobu Yoshibe, Kiyotaka Imai, Miki Kaneko, Shinichi Chikaki, Itsuro Saito, Akinori Tsuruma, Satoshi Sakamoto, Hiroshi Handa, Sachiko Matsuda, Moriaki Kusakabe

AIP ADVANCES　10　(1)　2020/01

DOI： 10.1063/1.5130478 　

eISSN： 2158-3226
Magnetic characteristics of a magnetic marker for localized tumor excision with a handheld magnetic probe Peer-reviewed

Yingyi Xiao, Oiendrila Bhowmik Debnath, Shinichi Chikaki, Akihiro Kuwahata, Mirjam Peek, Itsuro Saito, Shinsaku Maeda, Moriaki Kusakabe, Masaki Sekino

AIP ADVANCES　10　(1)　2020/01

DOI： 10.1063/1.5130495 　

eISSN： 2158-3226
Multicenter clinical trial on sentinel lymph node biopsy using superparamagnetic iron oxide nanoparticles and a novel handheld magnetic probe. International-journal Peer-reviewed

Taruno K, Kurita T, Kuwahata A, Yanagihara K, Enokido K, Katayose Y, Nakamura S, Takei H, Sekino M, Kusakabe M

Journal of surgical oncology　120　(8)　1391-1396　2019/12

DOI： 10.1002/jso.25747 　

ISSN： 0022-4790

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BACKGROUND: Sentinel lymph node biopsy is a standard staging procedure for early axillary lymph node-negative breast cancer. As an alternative to the currently used radioactive tracers for sentinel lymph node (SLN) detection during the surgical procedure, a number of studies have shown promising results using superparamagnetic iron oxide (SPIO) nanoparticles. Here, we developed a new handheld, cordless, and lightweight magnetic probe for SPIO detection. METHODS: Resovist (SPIO nanoparticles) were detected by the newly developed handheld probe, and the SLN detection rate was compared to that of the standard radioisotope (RI) method using radioactive colloids (99m Tc) and a blue dye (indigo carmine). This was a multicenter prospective clinical trial that included 220 patients with breast cancer scheduled for sentinel node biopsy after a clinical diagnosis of negative axillary lymph node from three facilities in Japan. RESULTS: Of the 210 patients analyzed, SLN was detected in 94.8% (199/210 cases, 90% confidence interval [CI]) with our magnetic method and in 98.1% (206/210 cases, 90% CI) with the RI method. The magnetic method exceeded the threshold identification rate of 90%. CONCLUSION: This was the first clinical study to use a novel handheld magnetometer to detect SLN, which we demonstrate to be not inferior to the RI method.
Development of magnet configurations for magnetic immunostaining (vol 8, 056732, 2018) Peer-reviewed

Miki Kaneko, Shinichi Chikaki, Sachiko Matsuda, Akihiro Kuwahata, Masayuki Namita, Itsuro Saito, Satoshi Sakamoto, Hiroshi Handa, Moriaki Kusakabe, Masaki Sekino

AIP ADVANCES　9　(9)　2019/09

DOI： 10.1063/1.5099384 　

ISSN： 2158-3226
Magnetically Promoted Rapid Immunofluorescence Staining for Frozen Tissue Sections International-journal Peer-reviewed

Tatsuya Onishi, Sachiko Matsuda, Yuki Nakamura, Junko Kuramoto, Akinori Tsuruma, Satoshi Sakamoto, Shunichi Suzuki, Daiichiro Fuchimoto, Akira Onishi, Shinichi Chikaki, Miki Kaneko, Akihiro Kuwahata, Masaki Sekino, Hiroshi Yasuno, Naohiro Hanyu, Tomoko Kurita, Hiroyuki Takei, Takashi Sakatani, Kanae Taruno, Seigo Nakamura, Tetsu Hayashida, Hiromitsu Jinno, Moriaki Kusakabe, Hiroshi Handa, Kaori Kameyama, Yuko Kitagawa

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY　67　(8)　575-587　2019/08

DOI： 10.1369/0022155419841023 　

ISSN： 0022-1554

eISSN： 1551-5044
乳癌磁気法センチネルリンパ節生検の臨床試験報告 AMED開発機構委託・多施設共同臨床研究

栗田智子, 垂野香苗, 柳原恵子, 中井麻木, 范姜明志, 坂谷貴司, 蒔田益次郎, 眞鍋恵理子, 榎戸克年, 明石定子, 沢田晃弘, 桑山隆志, 橋本梨佳子, 川手佳美, 斉藤逸郎, 桑波田晃弘, 関野正樹, 日下部守昭, 中村清吾, 武井寛幸

日本乳癌学会総会プログラム抄録集　27回　325-325　2019/07
Publisher: (一社)日本乳癌学会
犬における磁気ナノ粒子を用いたセンチネルリンパ節生検の最適化と臨床応用 Peer-reviewed

佐伯亘平, 池田凡子, 桑波田晃弘, 金子美樹, 関野正樹, 西村亮平, 日下部守昭, 中川貴之

乳癌基礎研究　27　25-32　2019/07
Publisher: 乳癌基礎研究会
ISSN： 1343-2028
Sentinel lymph node detection using newly developed handheld magnetometer in animal models Peer-reviewed

Akihiro Kuwahata, Kohei Saeki, Takayuki Nakagawa, Sachiko Matsuda, Hiroyuki Takei, Seigo Nakamura, Itsuro Saito, Masaki Sekino, Moriaki Kusakabe

CANCER SCIENCE　109　809-809　2018/12

ISSN： 1349-7006
安全な外科手技と整容性を考慮した手術に必要な手技国内初の新規磁気プローブを利用した乳癌手術への取り組み

垂野香苗, 中村清吾, 栗田智子, 武井寛幸, 桑波田晃弘, 関野正樹, 日下部守昭

日本臨床外科学会雑誌　79　(増刊)　406-406　2018/10
Publisher: 日本臨床外科学会
ISSN： 1345-2843

eISSN： 1882-5133
動物モデルにおける磁気プローブを用いたセンチネルリンパ節の検出(Sentinel lymph node detection using newly developed handheld magnetometer in animal models) Peer-reviewed

桑波田晃弘, 佐伯亘平, 中川貴之, 松田祐子, 武井寛幸, 中村清吾, 斎藤逸郎, 関野正樹, 日下部守昭

日本癌学会総会記事　77回　1256-1256　2018/09
Publisher: 日本癌学会
ISSN： 0546-0476
乳癌センチネルリンパ節生検における磁性体・磁気プローブシステムの有効性と展望 AMED委託多施設共同研究

栗田智子, 垂野香苗, 柳原恵子, 明石定子, 榎戸克年, 沢田晃暢, 中井麻木, 金丸里奈, 范姜明志, 桑山隆志, 坂谷貴司, 大橋靖雄, 金子美樹, 桑波田晃弘, 日下部守昭, 関野正樹, 蒔田益二郎, 中村清吾, 武井寛幸

日本乳癌学会総会プログラム抄録集　26回　369-369　2018/05
Publisher: (一社)日本乳癌学会
磁性体を利用したセンチネルリンパ節生検におけるセンチネルリンパ節の鉄染色の評価と臨床病理学的検討

垂野香苗, 中村清吾, 武井寛幸, 広田由子, 田澤咲子, 栗田智子, 柳原恵子, 榎戸克年, 桑山隆志, 明石定子, 沢田晃輔, 金子美樹, 桑波田晃弘, 関野正樹, 日下部守昭

日本乳癌学会総会プログラム抄録集　26回　413-413　2018/05
Publisher: (一社)日本乳癌学会
Development of magnet configurations for magnetic immunostaining Peer-reviewed

Miki Kaneko, Shinichi Chikaki, Sachiko Matsuda, Akihiro Kuwahata, Masayuki Namita, Itsuro Saito, Satoshi Sakamoto, Moriaki Kusakabe, Masaki Sekino

AIP ADVANCES　8　(5)　056732　2018/05

DOI： 10.1063/1.5007918 　

ISSN： 2158-3226

eISSN： 2158-3226
Development of device for quantifying magnetic nanoparticle tracers accumulating in sentinel lymph nodes Peer-reviewed

Akihiro Kuwahata, Miki Kaneko, Shinichi Chikaki, Moriaki Kusakabe, Masaki Sekino

AIP ADVANCES　8　(5)　S95-S95　2018/05

DOI： 10.1063/1.5006668 　

ISSN： 2158-3226

eISSN： 2158-3226
Handheld magnetic probe with permanent magnet and Hall sensor for identifying sentinel lymph nodes in breast cancer patients International-journal Peer-reviewed

Masaki Sekino, Akihiro Kuwahata, Tetsu Ookubo, Mikio Shiozawa, Kaichi Ohashi, Miki Kaneko, Itsuro Saito, Yusuke Inoue, Hiroyuki Ohsaki, Hiroyuki Takei, Moriaki Kusakabe

SCIENTIFIC REPORTS　8　(1)　1195-1195　2018/01

DOI： 10.1038/s41598-018-19480-1 　

ISSN： 2045-2322

eISSN： 2045-2322
Combined use of fluorescence with a magnetic tracer and dilution effect upon sentinel node localization in a murine model International-journal Peer-reviewed

Akihiro Kuwahata, Muneer Ahmed, Kohei Saeki, Shinichi Chikaki, Miki Kaneko, Wenqi Qiu, Zonghao Xin, Shinji Yamaguchi, Akiko Kaneko, Michael Douek, Moriaki Kusakabe, Masaki Sekino

INTERNATIONAL JOURNAL OF NANOMEDICINE　13　2427-2433　2018

DOI： 10.2147/IJN.S153163 　

ISSN： 1178-2013

eISSN： 1178-2013
リゾビスト・磁気ブローブ開発機を用いた乳癌センチネルリンパ節生検の多施設臨床研究

垂野香苗, 中村清吾, 柳原恵子, 蒔田益次郎, 榎戸克年, 中井麻木, 粟田智子, 桑山隆志, 沢田晃陽, 明石定子, 吉田美和, 桑波田晃弘, 金子美樹, 佐伯浩平, 中川貴之, 関野正樹, 日下部守昭, 武井寛幸

日本乳癌学会総会プログラム抄録集　25回　320-320　2017/07
Publisher: (一社)日本乳癌学会
A magnetic probe equipped with small-tip permanent magnet for sentinel lymph node biopsy Peer-reviewed

Miki Kaneko, Kaichi Ohashi, Shinichi Chikaki, Akihiro Kuwahata, Mikio Shiozawa, Moriaki Kusakabe, Masaki Sekino

AIP ADVANCES　7　(5)　2017/05

DOI： 10.1063/1.4975359 　

ISSN： 2158-3226
Three-dimensional sensitivity mapping of a handheld magnetic probe for sentinel lymph node biopsy Peer-reviewed

Akihiro Kuwahata, Shinichi Chikaki, Asli Ergin, Miki Kaneko, Moriaki Kusakabe, Masaki Sekino

AIP ADVANCES　7　(5)　056720　2017/05

DOI： 10.1063/1.4976338 　

ISSN： 2158-3226

eISSN： 2158-3226
Energy Flux due to Electromagnetic Fluctuations during Guide Field Magnetic Reconnection Peer-reviewed

Akihiro Kuwahata, Michiaki Inomoto, Ryoma Yanai, Yasushi Ono

PLASMA AND FUSION RESEARCH　11　1301087-1301087　2016/06

DOI： 10.1585/pfr.11.1301087 　

ISSN： 1880-6821

eISSN： 1880-6821
Characteristics of Magnetic Fluctuations during Magnetic Reconnection in Counter-Helicity Spheromak Merging Experiment Peer-reviewed

Ryoma Yanai, Akihiro Kuwahata, Michiaki Inomoto

PLASMA AND FUSION RESEARCH　11　2401069-2401069　2016

DOI： 10.1585/pfr.11.2401069 　

ISSN： 1880-6821

eISSN： 1880-6821
Electrification of a transient water flow in a PFA tube

Daichi Obata, Akihiro Kuwahata, Sunao Katsuki, Hidenori Akiyama

IEEJ Transactions on Fundamentals and Materials　135　(11)　698-703　2015/11/01
Publisher: The Institute of Electrical Engineers of Japan
DOI： 10.1541/ieejfms.135.698 　

ISSN： 0385-4205

eISSN： 1347-5533
Centre-solenoid-free merging start-up of spherical tokamak plasmas in UTST Peer-reviewed

M. Inomoto, T. G. Watanabe, K. Gi, K. Yamasaki, S. Kamio, R. Imazawa, T. Yamada, X. Guo, T. Ushiki, H. Ishikawa, H. Nakamata, N. Kawakami, T. Sugawara, K. Matsuyama, K. Noma, A. Kuwahata, H. Tanabe

Nuclear Fusion　55　(3)　033013　2015/03/01

DOI： 10.1088/0029-5515/55/3/033013 　

ISSN： 0029-5515

eISSN： 1741-4326
Excitation of electrostatic waves in the electron cyclotron frequency range during magnetic reconnection in laboratory overdense plasmas Peer-reviewed

A. Kuwahata, H. Igami, E. Kawamori, Y. Kogi, M. Inomoto, Y. Ono

Physics of Plasmas　21　(10)　102116　2014/10/01

DOI： 10.1063/1.4900872 　

ISSN： 1070-664X

eISSN： 1089-7674
Low-frequency magnetic fluctuation measurement during magnetic reconnection in counter-helicity plasma merging experiment Peer-reviewed

Akihiro Kuwahata, Hiroshi Tanabe, Shingo Ito, Michiaki Inomoto, Yasushi Ono

Electrical Engineering in Japan (English translation of Denki Gakkai Ronbunshi)　187　(2)　1-8　2014/04

DOI： 10.1002/eej.22401 　

ISSN： 0424-7760

eISSN： 1520-6416
Initiation of Impulsively Fast Magnetic Reconnection Induced by Current Sheet Ejection Peer-reviewed

M. Inomoto, S. Kamio, A. Kuwahata, T.G. Watanabe, K. Yamasaki, K. Kadowaki, T. Ito, Y. Kaminou, T. Yamada, Y. Ono

Plasma and Fusion Res.　8　2401112-2401112　2013/09
Publisher: The Japan Society of Plasma Science and Nuclear Fusion Research
DOI： 10.1585/pfr.8.2401112 　

ISSN： 1880-6821

eISSN： 1880-6821

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Fast magnetic reconnection mechanism triggered by current sheet ejection is studied in plasma merging laboratory experiment with a strong guide field. The current sheet is hardly compressed in the presence of the guide field and slow steady reconnection evolves in the early phase. It then transits to impulsively fast magnetic reconnection when the current sheet is ejected from the X point region. Behavior of the current sheet is investigated in detail by comparison with the fast reconnection case provided by anomalous resistivity.
Two-dimensional ion temperature measurement by application of tomographic reconstruction to Doppler spectroscopy Peer-reviewed

H. Tanabe, A. Kuwahata, H. Oka, M. Annoura, H. Koike, K. Nishida, S. You, Y. Narushima, A. Balandin, M. Inomoto, Y. Ono

Nuclear Fusion　53　(9)　093027　2013/09

DOI： 10.1088/0029-5515/53/9/093027 　

ISSN： 0029-5515

eISSN： 1741-4326
Two Dimensional Imaging Measurement of Magnetic Reconnection Outflow in the TS-4 Toroidal Plasma Merging Experiment Peer-reviewed

H. Tanabe, H. Oka, M. Annoura, A. Kuwahata, K. Kadowaki, Y. Kaminou, S. You, A. Balandin, M. Inomoto, Y. Ono

Plasma and Fusion Res.　8　2405088-2405088　2013/08
Publisher: The Japan Society of Plasma Science and Nuclear Fusion Research
DOI： 10.1585/pfr.8.2405088 　

ISSN： 1880-6821

eISSN： 1880-6821

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A novel 2D toroidal plasma flow velocimetry has been developed using tomographic reconstruction technique. The 2D imaging of local (R-Z) toroidal velocity is achieved by the vector tomographic reconstruction technique and multi-chord 2D spectroscopy by 35-channel optical fiber array. Numerical simulation for reconstruction of bi-directional toroidal velocity profile suggests that the cost-effective arrangement of the optical fiber for a toroidal plane is 7. We installed the system with 7 × 5 chords arrangement to the TS-4 device. This system successfully measured 2D bi-directional toroidal velocity profile around X point with 10% accuracy during the counter-helicity magnetic reconnection experiment.
Excitation and propagation of electromagnetic fluctuations with ion-cyclotron range of frequency in magnetic reconnection laboratory experiment Peer-reviewed

Michiaki Inomoto, Akihiro Kuwahata, Hiroshi Tanabe, Yasushi Ono

Physics of Plasmas　20　(6)　061209　2013/06

DOI： 10.1063/1.4811469 　

ISSN： 1070-664X

eISSN： 1089-7674
A laboratory experiment of magnetic reconnection: Outflows, heating, and waves in chromospheric jets Peer-reviewed

N. Nishizuka, Y. Hayashi, H. Tanabe, A. Kuwahata, Y. Kaminou, Y. Ono, M. Inomoto, T. Shimizu

Astrophysical Journal　756　(2)　152　2012/09/10

DOI： 10.1088/0004-637X/756/2/152 　

ISSN： 0004-637X

eISSN： 1538-4357
Study of particle acceleration during reconnection via TS-4 particle trajectory simulations Peer-reviewed

Patrick Copinger, Michiaki Inomoto, Toru Ii, Akihiro Kuwahata, Yoshinori Hayashi, Yasushi Ono

IEEJ Transactions on Fundamentals and Materials　132　(6)　411-416　2012
Publisher: The Institute of Electrical Engineers of Japan
DOI： 10.1541/ieejfms.132.411 　

ISSN： 0385-4205

eISSN： 1347-5533
Intermittent magnetic reconnection in TS-3 merging experiment Peer-reviewed

Y. Ono, Y. Hayashi, T. Ii, H. Tanabe, S. Ito, A. Kuwahata, T. Ito, Y. Kamino, T. Yamada, M. Inomoto

Physics of Plasmas　18　(11)　111213　2011/11

DOI： 10.1063/1.3662434 　

ISSN： 1070-664X
Development of effective power supply using electric double layer capacitor for static magnetic field coils in fusion plasma experiments Peer-reviewed

M. Inomoto, K. Abe, T. Yamada, A. Kuwahata, S. Kamio, Q. H. Cao, M. Sakumura, N. Suzuki, T. Watanabe, Y. Ono

Review of Scientific Instruments　82　(2)　023502　2011/02

DOI： 10.1063/1.3553283 　

ISSN： 0034-6748
Low frequency magnetic fluctuations during magnetic reconnection in laboratory experiment Peer-reviewed

Akihiro Kuwahata, Hiroshi Tanabe, Shingo Ito, Michiaki Inomato, Yasushi Ono

Plasma and Fusion Research　6　(2011)　1201127-1201127　2011
Publisher: The Japan Society of Plasma Science and Nuclear Fusion Research
DOI： 10.1585/pfr.6.1201127 　

ISSN： 1880-6821

eISSN： 1880-6821

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Misc. 167

Design method of surface receive coil with high SNR for various field intensities in MRI

48　(3)　53-59　2024

ISSN： 2432-0250
磁性ナノ粒子とダイヤモンドNVセンタを用いたウイルス検出手法の開発

桑波田晃弘, 廣田竜一, 村田祐眞, 薮上信

日本生体医工学会大会プログラム・抄録集(Web)　63rd　2024
大振幅高速パルス磁界に対する磁性粒子の磁化応答—Magnetization of Magnetic Particles by Applying Large Amplitude and High-Speed Pulsed Magnetic Fields—放電・プラズマ・パルスパワー研究会・放電・プラズマ・パルスパワー一般

安達友威, 桑波田晃弘, 薮上信, 中村英滋

電気学会研究会資料. EPP = The papers of technical meeting, IEE Japan / [放電・プラズマ・パルスパワー研究会] [編]　2023　(26-42)　41-45　2023/06/09
Publisher: 東京 : 電気学会
血液浄化膜の限外濾過性能に及ぼす超音波の影響

桑畑謙志, 木口崇彦, 山下明泰

日本血液浄化技術学会雑誌　31　(Supplement)　2023

ISSN： 2185-5927
宮崎平野西部MIK-1コアの花粉組成に基づく完新世の時空間的な植生復元

吉田明弘, 新地直人, 桑畑光博

日本花粉学会大会講演要旨集　64th (CD-ROM)　2023
Magnetometer with diamond nitrogen-vacancy center for biomedical applications

桑波田晃弘

電子情報通信学会大会講演論文集(CD-ROM)　2023　2023

ISSN： 1349-144X
Magnetization of Magnetic Particles by Applying Large Amplitude and High-Speed Pulsed Magnetic Fields

安達友威, 桑波田晃弘, 薮上信, 中村英滋

電気学会研究会資料(Web)　(EPP-23-026-042)　2023
Non-invasive treatment of lymph node metastasis with magnetic hyperthermia technology in murine tumor model

鏡味隆行, スフバートルアリウンブヤン, スフバートルアリウンブヤン, スフバートルアリウンブヤン, スフバートルアリウンブヤン, 桑波田晃弘, 桑波田晃弘, 桑波田晃弘, とんたっとろい, とんたっとろい, 篠原陸, 小玉哲也, 小玉哲也, 小玉哲也, 小玉哲也, 薮上信, 薮上信, 薮上信

日本癌学会学術総会抄録集(Web)　82nd　2023
Magnetic heating properties of hollow Fe₃O₄ particles with magnetic vortex structure

秋山遥, LOI Ton That, 桑波田晃弘, 薮上信, 小林悟

日本磁気学会学術講演概要集　47th　(2)　79-83　2023
Publisher: The Magnetics Society of Japan
DOI： 10.20819/msjtmsj.24tr816 　

ISSN： 1882-2959

eISSN： 2432-0471

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Hollow-structured Fe₃O₄ nanoparticles, with an increased surface area compared to solid counterparts, show promise in cancer therapy through potential applications in magnetic hyperthermia and drug delivery via encapsulation. This study investigates the shell thickness-dependent heating efficiency of hollow Fe₃O₄ nanoparticles with a magnetic vortex structure less prone to magnetization reversal. Using the solvothermal method, we maintained a nearly constant inner diameter (230 nm) while varying shell thickness (400 nm, 530 nm, and 720 nm in outer diameter denoted as H400, H530, and H720) by adjusting only the outer diameter through a change in reagent ratio and heating temperature. Under an applied AC magnetic field of 270 kHz, 429.5 Oe, the specific absorption rate (SAR) values of H400, H530, and H720 samples (calculated based on the initial temperature rising rate observed during the time interval of 0 to 30s) were 265.1, 130.2, and 120.9 W/g, respectively. These findings, supported by DC hysteresis loss experiments and micromagnetic simulations of AC hysteresis loss, indicate that particles with thinner shells at the same inner diameter exhibit enhanced heating efficiency due to a stable magnetic vortex structure and significant hysteresis loss. This highlights the potential utility of hollow nanoparticles with thin shells as a particle shape for magnetic hyperthermia.
固体量子センサを用いた癌セラノスティックス

桑波田晃弘

上原記念生命科学財団研究報告集(CD-ROM)　37　1-5　2023
Publisher: 東京 : 上原記念生命科学財団
ISSN： 2433-3441
ダイヤモンド量子センサによる生体磁場計測

荒井慧悟, 桑波田晃弘, 西谷大祐

New diamond = ニューダイヤモンド / ニューダイヤモンドフォーラム編　38　(3)　33-35　2022/07
Publisher: 東京 : ニューダイヤモンドフォーラム
ISSN： 1340-4792
Inverse problem-based estimation method to realize the magnetic force field of magnetic nanoparticles

吉岡輝, LIU Shuang, 伏見幹史, 桑波田晃弘, 関野正樹

電気学会全国大会講演論文集(CD-ROM)　2022　2022
Toward biomedical applications of diamond NV quantum sensors

関野正樹, 伏見幹史, 桑波田晃弘, 桑波田晃弘, 八井崇, 八井崇, 荒井慧悟, 岩崎孝之, 波多野睦子

応用物理学会春季学術講演会講演予稿集(CD-ROM)　69th　2022

ISSN： 2436-7613
An inverse problem approach to magnetic field space uniformity shape optimization of permanent magnets

田中治樹, 村田祐眞, 薮上信, 桑波田晃弘

電気学会全国大会講演論文集(CD-ROM)　2022　2022
Hybrid integration of Si₃N₄ grating on a diamond NV substrate using transfer printing

勝見亮太, 勝見亮太, 飛沢健, 桑波田晃弘, 桑波田晃弘, 岩崎孝之, 波多野睦子, JELEZKO Fedor, 関野正樹, 八井崇, 八井崇

応用物理学会春季学術講演会講演予稿集(CD-ROM)　69th　2022

ISSN： 2436-7613
Observation of Brain fields for Next Generation of Magnetoencephalography System

KUWAHATA Akihiro

日本眼科学会雑誌　126　2022

ISSN： 0029-0203
Heating of magnetic particles by application of high frequency pulsed magnetic field

安達友威, 桑波田晃弘, 薮上信, 中村英滋

日本磁気学会学術講演概要集　46th　2022

ISSN： 1882-2959
Bio-magnetic field measurement with nitrogen vacancy centres in diamond

桑波田晃弘, 桑波田晃弘, 荒井慧悟, 荒井慧悟, 西谷大祐, 藤崎伊久哉, 松木亮磨, 西尾有輝, XIN Zonghao, CAO Xinyu, 波多野雄治, 小野田忍, 真栄力, 宮川仁, 谷口尚, 山崎正俊, 寺地徳之, 大島武, 波多野睦子, 波多野睦子, 関野正樹, 岩崎孝之

日本生体磁気学会誌　35　(1)　2022

ISSN： 0915-0374
ダイヤモンドNVセンタを用いた心磁図

桑波田晃弘, 桑波田晃弘, 荒井慧悟, 西谷大祐, 藤崎伊久哉, 松木亮磨, 西尾有輝, 辛宗浩, 曹馨雨, 波多野雄治, 小野田忍, 眞榮力, 宮川仁, 谷口尚, 山崎正俊, 山崎正俊, 寺地徳之, 大島武, 波多野睦子, 関野正樹, 岩崎孝之

日本生体医工学会大会プログラム・抄録集(Web)　61st　(Abstract)　101_1-101_1　2022
Publisher: 公益社団法人日本生体医工学会
DOI： 10.11239/jsmbe.annual60.101_1 　

ISSN： 1347-443X

eISSN： 1881-4379

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癌や脳血管障害とならんで、世界の主要な死因の1つは心臓病である。心房細動、心室頻脈などの心不全は、神経細胞の異常興奮によって局所的に発生する電流伝播の不完全性によって生じると考えられている。心臓内で発生する生体電流伝播の非侵襲イメージングの手法は、超高感度磁気センサを用いた心磁図（心臓磁場の計測）である。生体活動に伴う生体電流から生じる磁場を計測するため、生体活動そのものを観測することが可能である。しかしながら、心臓と磁気センサのスタンドオフ距離が大きくなると、空間分解能が大幅に低下する。既存のSQUID（超電導量子干渉計）やOPM（光ポンピング磁力計）などの高感度磁気センサは、生体適合しない動作温度のため、心臓に対して数mmから1cmの離隔距離が必要であり、cmスケール程度の空間分解能である。本研究では、室温で動作可能なダイヤモンド窒素空孔中心（NVセンタ）に基づく固体量子センシングを駆使した磁場計測システムを開発し、生きているラットのmmスケールの空間分解能での心磁図を実現した。心臓表面1mmまで近接することで、高い空間分解能で心臓内の電流分布・磁場分布をイメージングすることに成功した。本研究は、心房細動、心室頻脈など、心不全の発生と進行のメカニズムを解明など、基礎医学への大きな貢献が期待できる。
ダイヤモンド量子センサを用いたラット心磁図の高分解能計測

関野正樹, 荒井慧悟, 桑波田晃弘, 桑波田晃弘, 西谷大祐, 藤崎伊久哉, 松木亮磨, 西尾有輝, 辛宗浩, 波多野雄治, 山崎正俊, 波多野睦子, 岩崎孝之

心電学関連春季大会プログラム・抄録集(Web)　2022　2022
磁性ナノ粒子の第二次高調波を利用したウイルス検出

廣田竜一, 村山徹, 勝見亮太, 川脇徳久, 薮上信, 薮上信, 五十嵐龍治, 根岸雄一, 日下部守昭, 日下部守昭, 関野正樹, 八井崇, 桑波田晃弘

電気関係学会東北支部連合大会講演論文集(CD-ROM)　2022　2022
Measurement of Steady State Visually Evoked Field Toward Development of Next Generation of Magnetoencephalography System

桑波田晃弘, 桑波田晃弘

神経眼科　39　(4)　293-300　2022
Publisher: The Japanese Neuro-Ophthalmology Society
DOI： 10.11476/shinkeiganka.39.293 　

ISSN： 0289-7024

eISSN： 2188-2002

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Magnetoencephalography（MEG）enables non-invasive measurements of magnetic signals that originate from neuronal electrical activities. These measurements can help to assess brain activities, the visual cortex, and ocular muscles. An optically pumped magnetometer（OPM）, which does not require a cryogenic cooling apparatus, has been developed as an alternative to su perconducting quantum interference device（SQUID）systems. A diamond nitrogen-vacancy（NV）magnetometer based on quantum magnetic sensing potentially offers superior spatial resolutions and integrations, where the device placement is more flexible and closer to the scalp for revealing brain activities. In this study, we observed and compared an MEG signal of a human steady-state visually evoked field using both SQUID and OPM systems under the application of variable stimulation patterns. We evaluated the optimal stimulation conditions, brain magnetic-field mapping, and the systemʼs dependence on the standoff distance between the sensor and the source of the magnetic field. This evaluation reveals the potential sensing capabilities of diamond NV for detecting bio-magnetic fields.
Demonstration of virus inactivation with visible light based on optical near field

高木雄斗, 勝見亮太, 日下部守昭, 桑波田晃弘, 川脇徳久, 五十嵐龍治, 根岸雄一, 関野正樹, 八井崇

応用物理学会秋季学術講演会講演予稿集(CD-ROM)　83rd　2022

ISSN： 2758-4704
Development of two dimensional imaging system with diamond NV and fiber array

桑波田晃弘

立石科学技術振興財団助成研究成果集(Web)　(31)　2022

ISSN： 0918-9939
磁気法乳癌センチネルリンパ節生検の有効性・有害事象の検証:AMED委託・多施設共同臨床研究

栗田智子, 垂野香苗, 武井寛幸, 中村清吾, 柳原恵子, 蒔田益次郎, 范姜明志, 明石定子, 榎戸克年, 桑山隆志, 坂谷貴司, 坂巻顕太郎, 田辺記生, 桑波田晃弘, 関野正樹, 日下部守昭

日本乳癌学会学術総会(CD-ROM)　30th　2022
Theoretical feasibility study on on-board magnetoencephalography with wearable magnetometers: マグネティックス/リニアドライブ合同研究会磁気センサ,リニアモータ・アクチュエータ,リニアドライブ技術一般,および磁気応用一般

2021　(66-81)　77-82　2021/06
非一様な方向分布を持つ磁気力を実現する磁場分布の逆問題的推定手法—Inverse problem-based estimation method of magnetic fields that realize the magnetic force with inhomogeneous orientation—マグネティックス/リニアドライブ合同研究会磁気センサ,リニアモータ・アクチュエータ,リニアドライブ技術一般,および磁気応用一般

吉岡輝, 劉爽, 伏見幹史, 桑波田晃弘, 関野正樹

電気学会研究会資料. MAG = The papers of technical meeting on magnetics, IEE Japan / マグネティックス研究会 [編]　2021　(66-81)　51-55　2021/06
Publisher: 東京 : 電気学会
Magnetically-induced temporal interference stimulation for focal and deep brain stimulation: マグネティックス/医用・生体工学合同研究会神経工学,生体磁気

2021　(26-42)　57-61　2021/03/16
Evaluation of localization of magnetic markers for non-palpable breast cancer excision: 非触知乳がん切除のための磁気マーカーの局在化の評価: マグネティックス/医用・生体工学合同研究会神経工学,生体磁気

2021　(26-42)　1-4　2021/03/16
Evaluation of localization of magnetic markers for non-palpable breast cancer excision

XIAO Yingyi, CHIKAKI Shinichi, KUWAHATA Akihiro, SAITO Itsuro, MAEDA Shinsaku, KUSAKABE Moriaki, SEKINO Masaki

電気学会研究会資料　(MAG-21-026-042/MBE-21-018-034)　2021
Shimming design of magnetic shield room using ferromagnetic plates

JIN Shixu, 桑波田晃弘, 隣真一, 波多野睦子, 関野正樹

電気学会全国大会講演論文集(CD-ROM)　2021　2021
Sensor array optimization of wearable magnetometers for potential applications in real world

CAO Xinyu, XIN Zonghao, KUWAHATA Akihiro, JIN Shixu, CHIKAKI Shinichi, OYAMA Kazuhiro, ANNO Yuki, YOSHIDA Teppei, SHIBATA Takayuki, SHIROTA Yuichiro, YUMOTO Masato, SAWAMURA Hiromasa, HATANO Mutsuko, YATSUI Takashi, SEKINO Masaki

日本生体医工学会大会プログラム・抄録集(Web)　60th　(Abstract)　482-482　2021
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.annual59.482 　

ISSN： 1347-443X

eISSN： 1881-4379

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Wearable intelligent devices for improved safety and comfort have become a hot topic in recent years. The brain-computer interface (BCI) method is typically based on electroencephalography (EEG), enabling users' direct interaction with devices in real time. However, rigid contact through EEG is inconvenient for daily applications. Magnetoencephalography (MEG), a noncontact brain signal measurement with high temporal and spatial resolutions, can be an excellent alternative for developing the BCI. In this study, we investigated the feasibility of wearable magnetometers, such as diamond nitrogen-vacancy centers, and optically pumped magnetometers for potential applications in on-board MEG. For the stimulation setting, we considered the steady-state visual-evoked response (SSVER), which is an essential brain activity for users. To investigate the presence of SSVER and denoising, we optimized the sensor array position and orientation. The results show the potential of intelligent devices for user interaction.
Theoretical feasibility study on on-board magnetoencephalography with wearable magnetometers

CAO Xinyu, XIN Zonghao, FUSHIMI Motofumi, CHIKAKI Shinichi, SHIROTA Yuichiro, YUMOTO Masato, SAWAMURA Hiromasa, SEKINO Masaki, KUWAHATA Akihiro, OYAMA Kazuhiro, ANNO Yuki, YOSHIDA Teppei, SHIBATA Takayuki, HATANO Mutsuko, YATSUI Takashi

電気学会研究会資料(Web)　(MAG-021-066-081/LD-21-026-041)　2021
Inverse problem-based estimation method of magnetic fields that realize the magnetic force with inhomogeneous orientation

吉岡輝, LIU Shuang, 伏見幹史, 桑波田晃弘, 関野正樹

電気学会研究会資料(Web)　(MAG-021-066-081/LD-21-026-041)　2021
Development of PID-based Automatic Temperature Control System for Magnetic Hyperthermia

鹿野晃弘, TONTHAT Loi, 桑波田晃弘, 薮上信

日本磁気学会学術講演概要集　45th　2021

ISSN： 1882-2959
Measurement of multiple bacteria species using magnetic nanoparticles by switching magnetic field

高橋隼之介, 小野寺英彦, 村山徹, TONTHAT L., 沖田和彦, 桑波田晃弘, 薮上信, 薮上信, 大坪和香子, 横田琴音, 横田琴音, 古谷真衣子, 金高弘恭, 三浦由則, 高橋英樹

日本磁気学会学術講演概要集　45th　2021

ISSN： 1882-2959
磁気温熱療法における感温磁性微粒子のワイヤレス温度検知技術の評価

北村大河, 鹿野晃弘, トンタットロイ, 桑波田晃弘, 薮上信, 薮上信

電気関係学会東北支部連合大会講演論文集(CD-ROM)　2021　2021
Time Domain Average Stochastic Resonance and its hardware model for Magnetocardiographic Detection at Room Temperature

LIAO Zhiqiang, SEKINO Masaki, KUWAHATA Akihiro, TABATA Hitoshi

応用物理学会春季学術講演会講演予稿集(CD-ROM)　68th　334-334　2021
Publisher: The Japan Society of Applied Physics
DOI： 10.11470/jsapmeeting.2021.1.0_334 　

ISSN： 2436-7613

eISSN： 2436-7613
Movable magnetically shielded room with 9-layers of permalloy for biomedical applications

Kuwahata Akihiro, Yamaguchi Takao, Fushimi Motofumi, Chikaki Shinichi, Niwa Yuuki, Sekino Masaki

Transactions of Japanese Society for Medical and Biological Engineering　Annual59　(Abstract)　549-549　2021
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.annual59.549 　

ISSN： 1347-443X

eISSN： 1881-4379

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The sensing of bio-magnetic fields originated from biological tissues, such as the brain and heart, enables to elucidate activities of humans and animals. However, due to the very-weak signal of bio-magnetic fields (10-14~10-12 Tesla) compared with geomagnetic fields (4-5 x 10-5 Tesla), a magnetically shielded room (MSR) and active magnetic cancelling coils are required to reduce environmental magnetic noises while sensing. The aim of this study is to develop a movable-MSR with 9-layers of permalloy and to achieve the highest level of shielding factor. The outside and inside dimension of the cubic-shaped MSR is 1000 and 300 mm for biomedical applications with small animals such as rats. We report the magnetic shielding performances against constant and alternating current magnetic fields by using highly-sensitive magnetic sensors (e.g., optically-pumped magnetometer and diamond nitrogen-vacancy center). As future works, we demonstrate high accuracy measurements of bio-magnetic fields such as magnetoencephalography and magnetocardiography.
Evaluation of antigen-antibody reaction of magnetic nanoparticles with directly adsorbed antibodies

米山毅, 村山徹, TONTHAT Loi, 桑波田晃弘, 薮上信, 佐藤佑哉, 寺村裕治, 大坪和香子, 小川智之

日本磁気学会学術講演概要集　45th　2021

ISSN： 1882-2959
健常犬におけるFerahemeを用いたセンチネルリンパ節磁気プローブ検出法と頭頸部リンパ節マッピングの有用性

山本貴恵, 池田凡子, 桑波田晃弘, 李捷生, 劉爽, 加藤大貴, 斎藤逸郎, 佐伯亘平, 藤田直己, 西村亮平, 関野正樹, 日下部守昭, 中川貴之

日本獣医学会学術集会講演要旨集　164th (CD-ROM)　2021

ISSN： 1347-8621
Numerical optimization and evaluation of a grating coupler on diamond NV bulk substrate

高橋哲, 勝見亮太, 飛沢健, 佐藤匠, 桑波田晃弘, 五十嵐龍治, 大島武, 増山雄太, 岩崎孝之, 波多野雄治, 波多野睦子, 牧野俊晴, 山崎聡, JELEZKO Fedor, 関野正樹, 八井崇

応用物理学会秋季学術講演会講演予稿集(CD-ROM)　82nd　2021

ISSN： 2758-4704
Numerical and experimental evaluation of magnetic markers for localized tumor excision with a handheld magnetic probe

XIAO Yingyi, OIENDRILA Bhowmik Debnath, 隣真一, 桑波田晃弘, 斎藤逸郎, 前田真作, 日下部守昭, 関野正樹

電気学会研究会資料　2020　(73-79)　31-35　2020/11/19
Publisher: 電気学会
Development of a magnetic probe using diamond quantum sensor for intraoperative sentinel lymph node biopsy

北泉隆裕, 桑波田晃弘, 齋地康太, 佐藤匠, 五十嵐龍治, 大島武, 増山雄太, 岩崎孝之, 波多野睦子, JELEZKO Fedor, 日下部守昭, 日下部守昭, 八井崇, 関野正樹

電気学会研究会資料　2020　(16)　47-52　2020/03/19
Publisher: 電気学会
Time Domain Average Stochastic Resonance System for Magnetocardiographic Detection at Room Temperature

Liao Zhiqiang, Kuwahata Akihiro, Sekino Masaki, Tabata Hitoshi

JSAP Annual Meetings Extended Abstracts　2020.1　2562-2562　2020/02/28
Publisher: The Japan Society of Applied Physics
DOI： 10.11470/jsapmeeting.2020.1.0_2562 　

ISSN： 2758-4704

eISSN： 2436-7613
Time Domain Average Stochastic Resonance System for Magnetocardiographic Detection at Room Temperature

LIAO Zhiqiang, KUWAHATA Akihiro, SEKINO Masaki, TABATA Hitoshi

応用物理学会春季学術講演会講演予稿集(CD-ROM)　67th　2020

ISSN： 2436-7613
A novel design method of TMS coil based on direct inversion of stream function

LIU Shuang, KUWAHATA Akihiro, SEKINO Masaki

日本生体医工学会大会プログラム・抄録集(Web)　59th　(Abstract)　244-244　2020
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.annual58.244 　

ISSN： 1347-443X

eISSN： 1881-4379

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Transcranial magnetic stimulation (TMS) has been widely used for research and clinical applications of neurological disorders. Existing methods for designing TMS coils are either based on researchers experience or based on optimize the combination of basis functions in specific surface like plane and sphere, which cannot be used when consider the curve of head. We want to develop a numerical method capable of optimizing TMS coils shape on arbitrary surfaces. In this work, We first derive the relationship between the induced electric field and the stream function analytically. Then we solve the stream function directly from the target electric field by Tikhonov regularization. Finally, the corresponding coil shape can be obtained by drawing the contour lines of the stream function. The result of coil shape is similar to fig-8 coil on the flat plane, which illustrates the effectiveness of our method.
Magnetic techniques for diagnosis and treatment of breast cancer

SEKINO Masaki, KUWAHATA Akihiro, HATANO Mutsuko, KUSAKABE Moriaki

日本磁気学会学術講演概要集　44th　2020

ISSN： 1882-2959
Diamond quantum sensors for biomagnetics

関野正樹, 桑波田晃弘, 八井崇, 湯本真人, 波多野睦子

日本生体磁気学会誌　33　(1)　2020

ISSN： 0915-0374
Detailed investigation of magnetoencephalography of steady state visual evoked potential signal observed by using SQUID/OPM sensors

桑波田晃弘, CAO Xinyu, JIN Shixu, XIN Zonghao, 隣真一, 今井清隆, 小山和博, 安野裕貴, 吉田鉄兵, 湯本真人, 波多野睦子, 八井崇, 関野正樹

日本生体磁気学会誌　33　(1)　2020

ISSN： 0915-0374
Fabrication of and Investigation on Grating coupler for the Improvement of Light Extraction Efficiency of Magnetometer with Nitrogen-Vacancy Center in Diamond

佐藤匠, 北泉隆裕, 齋地康太, 桑波田晃弘, 五十嵐龍治, 大島武, 増山雄太, 増山雄太, 岩崎孝之, 波多野睦子, 牧野俊晴, 山崎聡, JELEZKO Fedor, 日下部守昭, 日下部守昭, 関野正樹, 八井崇

応用物理学会春季学術講演会講演予稿集(CD-ROM)　67th　723-723　2020
Publisher: The Japan Society of Applied Physics
DOI： 10.11470/jsapmeeting.2020.1.0_723 　

eISSN： 2436-7613
乳腺非触知病変同定における磁気プローブの活用:AMED開発機構委託多施設共同臨床研究

栗田智子, 垂野香苗, 榎戸克年, 明石定子, 沢田晃暢, 柳原恵子, 中井麻木, 范姜明志, 佐藤あい, 斎藤逸郎, 関野正樹, 桑波田晃弘, 日下部守昭, 武井寛幸, 中村清吾

日本癌治療学会学術集会(Web)　58th　2020
磁性ナノ粒子・磁気プローブを使用した乳癌手術におけるセンチネルリンパ節生検の現状と展望

垂野香苗, 栗田智子, 榎戸克年, 中村清吾, 武井寛幸, 桑波田晃弘, 関野正樹, 日下部守昭, 日下部守昭

SNNS研究会学術集会プログラム抄録集　22nd　2020
Characterization of magnetic marker materials for localized breast cancer excision using a handheld magnetic probe

XIAO Yingyi, DEBNATH Oiendrila Bhowmik, CHIKAKI Shinichi, KUWAHATA Akihiro, PEEK Mirjam, SAITO Itsuro, MAEDA Shinsaku, KUSAKABE Moriaki, KUSAKABE Moriaki, SEKINO Masaki

電気学会研究会資料. MAG = The papers of technical meeting on magnetics, IEE Japan　2019　(40)　115-119　2019/06/27
Publisher: 電気学会
Development and Evaluation of Coil Sensor Design for Sentinel Lymph Node Biopsy in Gastric Cancer

井坂星南, 田中良, 桑波田晃弘, 隣真一, 日下部守昭, 日下部守昭, 関野正樹

電気学会研究会資料. MAG = The papers of technical meeting on magnetics, IEE Japan　2019　(40)　105-108　2019/06/27
Publisher: 電気学会
Development of an automatic magnetic immunostaining system for rapid diagnosis of cancer metastasis

関野正樹, 吉部明信, 今井清隆, 金子美樹, 隣真一, 桑波田晃弘, 斎藤逸郎, 鶴間章典, 坂本聡, 半田宏, 松田祐子, 日下部守昭

電気学会研究会資料　2019　(40)　7-10　2019/06/27
Publisher: 電気学会
Development of a rapid magnetic immunostaining method using antibody-labelled fluorescence magnetic beads

SAKAMOTO Satoshi, MATSUDA Sachiko, TSURUMA Akinori, ONISHI Tatsuya, KUWAHATA Akihiro, SEKINO Masaki, KUSAKABE Moriaki, KITAGAWA Yuko, HANDA Hiroshi

日本化学会春季年会講演予稿集(CD-ROM)　99th　2019
Coil Design for Transcranial Magnetic Stimulation Based on an Inverse Problem Theory Using Coil-Array Model

岸本陽大, 桑波田晃弘, 齋藤洋一, 関野正樹

日本生体磁気学会誌　32　(1)　2019

ISSN： 0915-0374
逆問題的アプローチによる経頭蓋磁気刺激におけるコイル設計

岸本陽大, 桑波田晃弘, 齋藤洋一, 関野正樹

生体医工学　Annual57　(Abstract)　S31_2-S31_2　2019
Publisher: 公益社団法人日本生体医工学会
DOI： 10.11239/jsmbe.annual57.s31_2 　

ISSN： 1347-443X

eISSN： 1881-4379

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従来の経頭蓋磁気刺激(TMS)におけるコイル設計の多くは、コイルの形状やパラメータを変えていくつかのパターンを用意し、得られる脳内電場を比較することによって最適なコイルを決定するため、全く新しいコイル形状が生まれにくく、実現したい脳内電場分布を生じるコイルの最適性の評価がしにくい。そこで本研究では、逆問題的に脳内電場分布からコイル形状を決定する手法を提案する。本手法では、非常に小さなコイルを並べた平面上にいくつも並べたコイルアレイを用い、脳モデルとして二次元平面型の脳モデルを用いた。コイルアレイに流す電流をベクトルI, 脳内の電場分布をベクトルEと表現すると、係数行列をAとして、これらの間には線形方程式AI=Eが成立する。この線形方程式をコイル電流ベクトルIについて逆問題的に解くことで、コイル形状を決定することができる。解析の結果、円形電場に対しては円形のコイル形状が得られて手法の妥当性を確かめることができた。また、電場分布に局所的な分布を与えることで、8の字コイルのような形状が得られた。これにより、今までとは全く異なるアプローチから8の字コイルを導くことができた。
Sentinel lymph node identification using magnetic nanoparticles and a magnetic probe

桑波田晃弘, 垂野香苗, 栗田智子, 中川貴之, 武井寛幸, 中村清吾, 斎藤逸郎, 日下部守昭, 日下部守昭, 関野正樹

磁性流体連合講演会講演論文集　2019　2019
ダイヤモンドNVセンサを用いた磁気ナノ粒子検出のための磁気プローブの開発

北泉隆裕, 桑波田晃弘, 齋地康太, 佐藤匠, 五十嵐龍治, 増山雄太, 岩崎孝之, 波多野睦子, 八井崇, 関野正樹

電気学会基礎・材料・共通部門大会講演論文集(CD-ROM)　2019　2019
Development and Evaluation of Coil Sensor Design for Sentinel Lymph Node Biopsy in Gastric Cancer

井坂星南, 田中良, 桑波田晃弘, 隣真一, 日下部守昭, 日下部守昭, 関野正樹

電気学会研究会資料　2019　(MAG-19-040-066/LD-19-028-054)　105-108　2019
Publisher: 東京 : 電気学会
磁気ナノ粒子を用いた新規センチネルリンパ節検出法の確立

池田凡子, 佐伯亘平, 桑波田晃弘, 藤原玲奈, 鎌田正利, 吉竹涼平, 嘉本諭, 品田真央, 衛藤翔太朗, PEEK C. L. Mirjam, 西村亮平, 日下部守昭, 関野正樹, 中川貴之

日本獣医学会学術集会講演要旨集　162nd　2019

ISSN： 1347-8621
Investigation on light extraction efficiency in magnetometer with Nitrogen-Vacancy center in diamond by grating coupler

佐藤匠, 北泉隆裕, 齋地康太, 桑波田晃弘, 五十嵐龍治, 大島武, 増山雄太, 増山雄太, 岩崎孝之, 波多野睦子, JELEZKO Fedor, 日下部守昭, 日下部守昭, 関野正樹, 八井崇

Optics & Photonics Japan講演予稿集(CD-ROM)　2019　2019
ドーム型磁石を用いた磁気免疫染色における染色一様性の評価

藤田俊祐, 関野正樹, 桑波田晃弘, 金子美樹, 隣真一, 松田祐子, 坂本聡, 斎藤逸郎, 半田宏, 日下部守昭

生体医工学　57　(0)　S157_2-S157_2　2019
Publisher: 公益社団法人日本生体医工学会
DOI： 10.11239/jsmbe.Annual57.S157_2 　

ISSN： 1347-443X

eISSN： 1881-4379

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磁石と抗体標識蛍光磁気ビーズを用いた磁気免疫染色法は、ビーズに内包されたフェライトを磁石により磁化し、組織切片上に素早く引き付けることで、抗原抗体反応を促進し、がん抗原の検出をわずか数分で可能とする。正確な診断を短時間で行うためには均一かつ強力な磁力によって、ビーズを空間的一様に組織切片へと引き付ける必要がある。本研究では、磁気免疫染色法においてドーム型形状の磁石を用いることを提案し、磁気免疫染色実験を実施し染色効果の確認を行った。磁気ビーズの運動を数値解析した結果、典型的な円柱磁石では磁石中央と磁石端でビーズに生じる磁力が不均一になるために、空間一様性の高い染色ができないことが明らかとなった。そこで、均一な磁力を発生させるドーム型磁石の設計と染色時間中の一様性の評価を実施し、直径30mmで高さ30mmの上面に曲率半径50mmの球面を有する磁石が最適であることを明らかとした。また、上皮成長因子受容体を高発現したヒト類表皮がん培養細胞の染色実験を実施し、ドーム型磁石は円柱磁石に比べて蛍光強度の変化の少ない空間一様性の高い染色が1分間で可能であることを示し、提案するドーム型磁石の有用性を明らかとした。
Development of a handheld magnetometer with optimized cavity-shaped magnet for identifying magnetic nanoparticles in biomedical tissues

桑波田晃弘, 日下部守昭, 日下部守昭, 隣真一, 斎藤逸郎, 関野正樹

電気学会研究会資料. MSS　2018　(30)　75-78　2018/12/20
Publisher: 電気学会
Magnetic Probes for Sentinel Lymph Node Identification in Laparoscopic Surgery

田中良, 桑波田晃弘, 隣真一, 松田祐子, 天田塩, 日下部守昭, 日下部守昭, 関野正樹

電気学会研究会資料. MSS　2018　(30)　69-73　2018/12/20
Publisher: 電気学会
Development of a method for estimating magnetic field distribution in an object containing a magnetic material from View Line MRI (マグネティックスマイクロマシン・センサシステムバイオ・マイクロシステム合同研究会磁気・バイオ・MEMS・IOT等に関連するセンシング技術の研究発表)

LIU Shuang, QIU Wenqi, MAGGIORA Gabriel Della, KUWAHATA Akihiro, KUSAKABE Moriaki, IRARRAZAVAL Pablo, SEKINO Masaki

電気学会研究会資料. MSS　2018　(30)　11-15　2018/12/20
Publisher: 電気学会
Development of a method for estimating magnetic field distribution in an object containing a magnetic material from View Line MRI (マグネティックスマイクロマシン・センサシステムバイオ・マイクロシステム合同研究会磁気・バイオ・MEMS・IOT等に関連するセンシング技術の研究発表)

LIU Shuang, QIU Wenqi, MAGGIORA Gabriel Della, KUWAHATA Akihiro, KUSAKABE Moriaki, IRARRAZAVAL Pablo, SEKINO Masaki

電気学会研究会資料. MAG = The papers of technical meeting on magnetics, IEE Japan　2018　(204)　11-15　2018/12/20
Publisher: 電気学会
Sentinel node navigation surgery using SPIO and magnetically-promoted rapid immunofluorescence staining

松田祐子, 桑波田晃弘, 関野正樹, 日下部守昭, 隣真一, 田中良, 天田塩, 大西達也, 坂本聡, 半田宏, 栗田智子, 武井寛幸, 垂野香苗, 中村清吾, 北川雄光

電気学会研究会資料　2018　(204)　55-57　2018/12/20
Publisher: 電気学会
Design of magnet shape and characterization by numerical analysis for magnetic immunostaining

藤田俊祐, 桑波田晃弘, 金子美樹, 隣真一, 松田祐子, 坂本聡, 斎藤逸郎, 半田宏, 日下部守昭, 関野正樹

電気学会研究会資料　2018　(204)　63-67　2018/12/20
Publisher: 電気学会
Development of a magnetic probe using a diamond NV sensor for detecting magnetic nanoparticles

北泉隆裕, 桑波田晃弘, 齋地康太, 佐藤匠, 八井崇, 関野正樹, 五十嵐龍治, 増山雄太, 岩崎孝之, 波多野睦子, Jelezko Fedor

電気学会研究会資料. MAG = The papers of technical meeting on magnetics, IEE Japan　2018　(204)　79-84　2018/12/20
Publisher: 電気学会
Development of a magnetic probe using a diamond NV sensor for detecting magnetic nanoparticles

北泉隆裕, 桑波田晃弘, 齋地康太, 佐藤匠, 八井崇, 関野正樹, 五十嵐龍治, 増山雄太, 岩崎孝之, 波多野睦子, Jelezko Fedor

電気学会研究会資料. MSS　2018　(30)　79-84　2018/12/20
Publisher: 電気学会
乳癌センチネルリンパ節生検における磁性体・磁気プローブシステムの有効性と展望 AMED委託多施設共同研究

栗田智子, 垂野香苗, 柳原恵子, 明石定子, 榎戸克年, 沢田晃暢, 中井麻木, 金丸里奈, 范姜明志, 桑山隆志, 坂谷貴司, 大橋靖雄, 金子美樹, 桑波田晃弘, 日下部守昭, 関野正樹, 蒔田益二郎, 中村清吾, 武井寛幸

日本乳癌学会総会プログラム抄録集　26回　369-369　2018/05
Publisher: (一社)日本乳癌学会
磁性体を利用したセンチネルリンパ節生検におけるセンチネルリンパ節の鉄染色の評価と臨床病理学的検討

垂野香苗, 中村清吾, 武井寛幸, 広田由子, 田澤咲子, 栗田智子, 柳原恵子, 榎戸克年, 桑山隆志, 明石定子, 沢田晃輔, 金子美樹, 桑波田晃弘, 関野正樹, 日下部守昭

日本乳癌学会総会プログラム抄録集　26回　413-413　2018/05
Publisher: (一社)日本乳癌学会
A method for Quantification of SPIONs by MRI (マグネティックス研究会生体磁気,磁性材料,磁気応用一般)

電気学会研究会資料. MAG = The papers of technical meeting on magnetics, IEE Japan　2018　(31)　5-9　2018/03/20
Publisher: 電気学会
Analysis of magnetic force distribution of magnet array for magnetic immunostaining

金子美樹, 隣真一, 松田祐子, 桑波田晃弘, 並田将幸, 斉藤逸郎, 坂本聡, 日下部守昭, 関野正樹

電気学会研究会資料. MAG = The papers of technical meeting on magnetics, IEE Japan　2018　(31)　11-15　2018/03/20
Publisher: 電気学会
A method for Quantification of SPIONs by MRI

LIU Shuang, QIU Wenqi, MAGGIORA Della Gabriel, KUWAHATA Akihiro, KUSAKABE Moriaki, IRARRAZAVAL Pablo, SEKINO Masaki

電気学会研究会資料　(MAG-18-031-033.035-039)　2018
院内の疑義照会の実態調査と腎排泄型薬物に対する薬剤師の介入

伊集院聖司, 水谷駿介, 有嶋祐未, 大淵友紀子, 久保田麻伊, 永井海舟, 永濱瑞希, 藤脇孝哉, 桑幡正幸, 清水華菜, 屋久直紀, 田中彩, 原田利江, 合田明博, 本室彩, 益田宏代, 塚田祥子, 馬場礼治, 深水聡太, 田中和子

日本腎臓病薬物療法学会誌　7　(2 Supplement)　2018

ISSN： 2187-0411
Reducing MRI artifacts induced by SPIONs

LIU Shuang, QIU Wenqi, KUWAHATA Akihiro, CHIKAKI Shinichi, LANE Laura, MONTALBA Cristian, KUSAKABE Moriaki, IRARRAZAVAL Pablo, SEKINO Masaki

日本生体医工学会大会プログラム・抄録集(Web)　57th　(Abstract)　S382-S382　2018
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.annual56.s382 　

ISSN： 1347-443X

eISSN： 1881-4379

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Sentinel lymph node biopsy using Superparamagnetic iron oxide nanoparticles (SPIONs) is a promising method for breast cancer treatment. However, due to too much SPIONs accumulated in the injection position, a large susceptibility artifact arises in the Magnetic Resonance Imaging(MRI), causing information around the injection position cannot be acquired. In order to reduce this artifact, studies were carried out on clinic MRI system to find a superior MRI sequence upon Spin Echo, Gradient Echo and Ultra-Short TE sequences also with optimizing the parameter setting including echo time(TE) and voxel size. Concentration of Fe in the sample we used is 27.875mg/ml,The result shows Spin Echo Sequence with short TE provide image with smallest area of artifact.
Magnetic sensing probe of Nitrogen-Vacancy center for detecting cancer metastasis

Saichi Kota, Sato Takumi, Kitaizumi Takahiro, Kuwahata Akihiro, Sekino Masaki, Igarashi Ryuji, Masuyama Yuta, Iwasaki Takayuki, Hatano Mutsuko, Jelezko Fedor, Yatsui Takashi

JSAP Annual Meetings Extended Abstracts　79th　657-657　2018
Publisher: The Japan Society of Applied Physics
DOI： 10.11470/jsapmeeting.2018.2.0_657 　

ISSN： 2758-4704

eISSN： 2436-7613
腹腔鏡手術におけるセンチネルリンパ節生検に用いる磁気プローブの開発

田中良, 桑波田晃弘, 隣真一, 松田祐子, 天田塩, 日下部守昭, 日下部守昭, 関野正樹

電気学会基礎・材料・共通部門大会講演論文集(CD-ROM)　2018　2018
磁気プローベとSPIOを用いたsingle tracer methodによる腹腔鏡下SNNSの妥当性の検証

天田塩, 松田祐子, 後藤修, 隣真一, 桑波田晃弘, 斎藤逸郎, 関野正樹, 日下部守昭, 日下部守昭, 眞柳修平, 川久保博文, 竹内裕也

SNNS研究会学術集会プログラム抄録集　20th　2018
センチネルリンパ節の同定,転移診断,治療,未来に向けた基礎研究

松田祐子, 天田塩, 大西達也, 鈴木俊一, 淵本大一郎, 大西彰, 坂本聡, 半田宏, 桑波田晃弘, 関野正樹, 日下部守昭, 栗田智子, 武井寛幸, 後藤修, 垂野香苗, 中村清吾, 眞柳修平, 川久保博文, 竹内裕也, 北川雄光

SNNS研究会学術集会プログラム抄録集　20th　2018
Sentinel Lymph Node Biopsy Using Magnetic Nanoparticles and Magnetic Probe

日下部守昭, 日下部守昭, 垂野香苗, 栗田智子, 武井寛幸, 中村清吾, 桑波田晃弘

まぐね　13　(4)　174-180　2018
Publisher: 日本応用磁気学会
ISSN： 1880-7208
Convex magnet configuration for magnetic immunostaining

KANEKO MIKI, KUWAHATA AKIHIRO, MATSUDA SACHIKO, CHIKAKI CHINICHI, NAMITA MASAYUKI, SAITO ITSURO, SAKAMOTO SATOSHI, KUSAKABE MORIAKI, SEKINO MASAKI

Transactions of Japanese Society for Medical and Biological Engineering　56　(0)　S402-S402　2018
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.Annual56.S402 　

ISSN： 1347-443X

eISSN： 1881-4379

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Magnetic immunostaining can significantly promote the immunoreaction using a magnet and antibody-labeled fluorescent ferrite (FF) beads and diagnose the cancer metastasis during operation. We proposed a convex magnet for uniformly attracting antibody-labeled FF beads toward antigens on an entire tissue section and evaluated the magnet configuration by the curvature radius in the magnet surface. In numerical analysis result, the optimal curvature radius was 55 mm.
Development of device for quantifying magnetic tracers accumulating in sentinel lymph nodes

KUWAHATA AKIHIRO, KANEKO MIKI, CHIKAKI SHINICHI, SAITO ITSURO, KUSAKABE MORIAKI, SEKINO MASAKI

Transactions of Japanese Society for Medical and Biological Engineering　56　(0)　S95-S95　2018
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.annual56.s95 　

ISSN： 1347-443X

eISSN： 1881-4379

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Sentinel lymph node biopsy (SLNB) using magnetic tracers is a promising technique in the treatment of breast cancer to evaluate the presence of metastasis in sentinel lymph nodes (SLNs). Selection of the first SLN, which contains the largest amount of iron of magnetic nanoparticles, in some resected nodes can help to investigate the metastasis because cancer most likely metastasizes to that node. However, iron distributions in SLNs of varied sizes (generally 3-20 mm) are unidentified.In this study, we developed a device can quantify iron amount in SLNs without the dependencies of the distributions and sizes. The device, currently, quantified the iron in magnetic phantoms that is the size of 3-20 mm with varied iron-distributions, within the error of 10%. These results indicate the developed device is useful for quantifying the magnetic nanoparticles accumulating in SLNs.
The sensitivity mapping of a handheld magnetic probe with a permanent magnet for sentinel lymph node biopsy

Kuwahata Akihiro, Chikaki Shinichi, Kaneko Miki, Shiozawa Mikio, Takei Hiroyuki, Nakamura Seigo, Nakagawa Takayuki, Saeki Kohei, Saito Itsuro, Kusakabe Moriaki, Sekino Masaki

Transactions of Japanese Society for Medical and Biological Engineering　55Annual　(5AM-Abstract)　390-390　2017
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.55annual.390 　

ISSN： 1347-443X

eISSN： 1881-4379

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The magnetic technique using a magnetic tracer and handheld magnetic probe with permanent magnet can be alternatives to the radioisotope technique as a noninvasive promising method for sentinel lymph node biopsy. To identify one sentinel lymph node, 5 mm spatial resolution of the probe is required because sentinel lymph nodes are often clustered in axillary lymph nodes. The aim of this study is to demonstrate a spatial resolution of the magnetic probe by a sensitivity mapping measurement with high spatial resolutions.The longitudinal sensitivity and lateral resolution of the probe was approximately 8 mm and 4 mm, respectively, for 5 μL of the magnetic tracer (Resovist). The probe discriminated the one phantom from two phantoms separated 4 mm in the lateral direction. These results indicate that the magnetic probe with the permanent magnet has the ability to identify one sentinel lymph node from the node clusters in actual usages.
磁気トレーサー粒子を用いたがん転移診断における複数トレーサー併用法の原理実証

桑波田晃弘, 佐伯亘平, MUNEER Ahmed, 隣真一, 金子美樹, 山口秦司, QIU W., 日下部守昭, 関野正樹

日本磁気学会学術講演概要集　41st　2017

ISSN： 1882-2959
乳がんセンチネルリンパ節生検に用いる永久磁石型磁気プローブの空間感度分布特性

桑波田晃弘, ERGIN Asli, 金子美樹, 隣真一, 田邊記生, 塩澤幹雄, 武井寛幸, 中村清吾, 中川貴之, 佐伯亘平, 斉藤逸郎, 日下部守昭, 日下部守昭, 関野正樹

電気学会基礎・材料・共通部門大会講演論文集(CD-ROM)　2017　2017
The sensitivity mapping of a handheld magnetic probe with a permanent magnet for sentinel lymph node biopsy

Kuwahata Akihiro, Kusakabe Moriaki, Sekino Masaki, Chikaki Shinichi, Kaneko Miki, Shiozawa Mikio, Takei Hiroyuki, Nakamura Seigo, Nakagawa Takayuki, Saeki Kohei, Saito Itsuro

Transactions of Japanese Society for Medical and Biological Engineering　55　(5)　390-390　2017
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.55annual.390 　

ISSN： 1347-443X

eISSN： 1881-4379

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The magnetic technique using a magnetic tracer and handheld magnetic probe with permanent magnet can be alternatives to the radioisotope technique as a noninvasive promising method for sentinel lymph node biopsy. To identify one sentinel lymph node, 5 mm spatial resolution of the probe is required because sentinel lymph nodes are often clustered in axillary lymph nodes. The aim of this study is to demonstrate a spatial resolution of the magnetic probe by a sensitivity mapping measurement with high spatial resolutions.The longitudinal sensitivity and lateral resolution of the probe was approximately 8 mm and 4 mm, respectively, for 5 μL of the magnetic tracer (Resovist). The probe discriminated the one phantom from two phantoms separated 4 mm in the lateral direction. These results indicate that the magnetic probe with the permanent magnet has the ability to identify one sentinel lymph node from the node clusters in actual usages.
The profiles of ion temperature and flow in counter-helicity plasma merging

Akihiro Kuwahata, Yasuhiro Kaminou, Ryoma Yanai, Michiaki Inomoto, Yasushi Ono

IEEJ Transactions on Fundamentals and Materials　136　(4)　212-213　2016
Publisher: Institute of Electrical Engineers of Japan
DOI： 10.1541/ieejfms.136.212 　

ISSN： 0385-4205

eISSN： 1347-5533
Experimental investigation of electromagnetic fluctuations during fast reconnection in the presence of a guide field

桑波田晃弘, 井通暁, 矢内亮馬, 小野靖

プラズマ・核融合学会年会(Web)　32nd　2015
Experimental study of plasmoid formation by use of external magnetic field index

Kent Nishida, Akihiro Kuwahata, Koya Saito, Yasushi Ono

IEEJ Transactions on Fundamentals and Materials　135　(8)　498-499　2015
Publisher: Institute of Electrical Engineers of Japan
DOI： 10.1541/ieejfms.135.498 　

ISSN： 0385-4205

eISSN： 1347-5533
22aBH-5 Generation and stabilization condition of plasmoid in Laboratory Magnetic Reconnection Experiment

Nishida K, Ono Y, Saito K, Kaminou Y, Kuwahata A

Meeting Abstracts of the Physical Society of Japan　70　(0)　854-854　2015
Publisher: The Physical Society of Japan
DOI： 10.11316/jpsgaiyo.70.1.0_854 　

ISSN： 2189-079X

eISSN： 2189-0803
Excitation of Electrostatic Waves in the Electron Cyclotron Frequency Range during Magnetic Reconnection in Laboratory Overdense Plasmas

KUWAHATA Akihiro, IGAMI Hiroe, KAWAMORI Eiichirou, KOGI Yuichiro, INOMOTO Michiaki, ONO Yasushi

プラズマプロセシング研究会プロシーディングス(CD-ROM)　32nd　2014
Structure of Two Component Magnetic Reconnection and the Generation of High Frequency Magnetic Fluctuations by the Counter-helicity Merging

YANAI Ryoma, KUWAHATA Akihiro, INOMOTO Michiaki, ONO Yasushi

プラズマプロセシング研究会プロシーディングス(CD-ROM)　32nd　2014
Structure of Two Component Magnetic Reconnection and the Generation of High Frequency Magnetic Fluctuations by the Counter-helicity Merging

YANAI Ryoma, KUWAHATA Akihiro, INOMOTO Michiaki, ONO Yasushi

プラズマ・核融合学会年会(Web)　31st　2014
1P2-H02 Robot service architecture based on room condition estimation by distributed sensors(Integrating Ambient Intelligence)

Pyo Yoonseok, Nagata Akihiro, Nakashima Kouhei, Kuwahata Shunya, Tsuji Tokuo, Morooka Ken'ichi, Kurazume Ryo, Hasegawa Tsutomu

The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec)　2014　_1P2-H02_1-_1P2-H02_4　2014
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmermd.2014._1p2-h02_1 　

ISSN： 2424-3124

eISSN： 2424-3124

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This paper introduces an information processing architecture named ROS-TMS for informationally structured environment. This architecture enables to handle several practical service tasks such as state estimation in a room using accumulated information in a database, and automatic planning and execution for suitable service tasks. As an application of the proposed ROS-TMS, we present an emergency detection and alert system using distributed sensors and a service robot.
リコネクション加熱実験における非等方イオン温度のドップラー分光計測

西田賢人, 桑波田晃弘, 案浦正将, 小野靖

核融合エネルギー連合講演会(CD-ROM)　10th　2014
Ion heating during merging/reconnection startup of ST in MAST

TANABE Hiroshi, YAMADA Takuma, INOMOTO Michiaki, ONO Yasushi, WATANABE Takenori, GI Keii, KUWAHATA Akihiro, KADOWAKI Kazutake, KAMINO Yasuhiro, KOIKE Hideya, NISHIDA Kenji, IMANAKA Takeshi, YAMANAKA Seiki, MICHAEL Clive, CROWLEY Brendan, CONWAY Neil, SCANNELL Rory, GRYAZNEVICH Mikhail

プラズマプロセシング研究会プロシーディングス(CD-ROM)　32nd　2014
低周波磁場揺動によるガイド磁場磁気リコネクションの高速化機構

桑波田晃弘, 矢内亮馬, 田辺博士, 井通暁, 小野靖

核融合エネルギー連合講演会(CD-ROM)　10th　2014
大型球状トカマク実験MASTの合体立ち上げにおけるイオン急速加熱現象

田辺博士, 山田琢磨, 渡辺岳典, 魏啓為, 桑波田晃弘, 門脇和丈, 神納康宏, 小池秀弥, 西田賢人, MICHAEL Clive, CROWLEY Brendan, CONWAY Neil, SCANNELL Rory, GRYAZNEVICH Mikhai, 井通暁, 小野靖

核融合エネルギー連合講演会(CD-ROM)　10th　2014
Ion heating during merging/reconnection startup of ST in MAST

田辺博士, 山田琢磨, 渡辺岳典, 魏啓為, 桑波田晃弘, 門脇和丈, 神納康宏, 小池秀弥, 西田賢人, 今中豪, 山中晴揮, MICHAEL Clive, CROWLEY Brendan, CONWAY Neil, SCANNELL Rory, GRYAZNEVICH Mikhail, 井通暁, 小野靖

プラズマ・核融合学会年会(Web)　31st　2014
ひので-実験室プラズマ共同実験による彩層ジェット再現実験

西塚直人, 林由記, 田辺博士, 桑波田晃弘, 神納康宏, 井通暁, 小野靖, 清水敏文

日本天文学会年会講演予稿集　2014　2014

ISSN： 1347-0639
Spectroscopic measurement of anisotropic ion temperature during reconnection heating of merging CT plasmas

Kento Nishida, Akihiro Kuwahata, Masanobu Annoura, Yasushi Ono

IEEJ Transactions on Fundamentals and Materials　134　(9)　519-520　2014
Publisher: Institute of Electrical Engineers of Japan
DOI： 10.1541/ieejfms.134.519 　

ISSN： 0385-4205

eISSN： 1347-5533
Measurement of magnetic fluctuation during formation of field-reversed configuration by counter-helicity plasma merging

Ryoma Yanai, Akihiro Kuwahata, Michiaki Inomoto, Yasushi Ono

IEEJ Transactions on Fundamentals and Materials　134　(9)　521-522　2014
Publisher: Institute of Electrical Engineers of Japan
DOI： 10.1541/ieejfms.134.521 　

ISSN： 0385-4205

eISSN： 1347-5533
29pAT-12 Laboratory Experiment of Magnetic Reconnection of Chromospheric Jets in the Sunspot Light Bridge

Nishizuka Naoto, Hayashi Yoshinori, Tanabe Hiroshi, Kuwahata Akihiro, Kamino Yasuhiro, Inomoto Michiaki, Ono Yasushi

Meeting Abstracts of the Physical Society of Japan　69　(0)　275　2014
Publisher: The Physical Society of Japan
DOI： 10.11316/jpsgaiyo.69.1.2.0_275_1 　

ISSN： 1342-8349

eISSN： 2189-0803
磁気リコネクション室内実験における非定常性と高速化

井通暁, 神尾修治, 桑波田晃弘, 渡辺岳典, 伊藤大智, 門脇和丈, 竹村剛一良, 山崎広太郎, 山田琢磨, 小野靖

日本物理学会講演概要集　68　(1)　2013

ISSN： 1342-8349
Electron Temperature and Potential Structures in Magnetic Reconnection Laboratory Experiment

GAO Boxin, KUWAHATA Akihiro, INOMOTO Michiaki, ONO Yasushi

電気学会プラズマ研究会資料　PST-13　(130-146)　2013
MAST大型実験における磁気リコネクションのイオン加熱

田辺博士, 山田琢磨, 桑波田晃弘, 渡辺岳典, 魏啓為, 案浦正将, 門脇和丈, 山埼広太郎, 神納康宏, 小池秀弥, 西田賢人, GRYAZNEVICH Mikhail, 井通暁, 小野靖

プラズマ・核融合学会年会(Web)　30th　2013
26pEA-3 Non-steady and Fast Magnetic Reconnection in Laboratory Experiment

Inomoto M, Ono Y, Kamio S, Kuwahata A, Watanabe T. G, Ito T, Kadowaki K, Takemura K, Yamasaki K, Yamada T

Meeting Abstracts of the Physical Society of Japan　68　(0)　263-263　2013
Publisher: The Physical Society of Japan
DOI： 10.11316/jpsgaiyo.68.1.2.0_263_4 　

ISSN： 1342-8349

eISSN： 2189-0803
26pYC-7 Msgnetic and Electrostatic Fluctuation Messurements in the Vicinity of Current Sheet in Magnetic Reconnection Experiment

Inomoto M., Kuwahata A., Gao B., Ono Y.

Meeting abstracts of the Physical Society of Japan　67　(1)　275-275　2012/03/05
Publisher: The Physical Society of Japan (JPS)
ISSN： 1342-8349
磁気リコネクション室内実験における電流シート近傍の波動励起

井通暁, 桑波田晃弘, GAO B., 小野靖

日本物理学会講演概要集　67　(2)　2012

ISSN： 1342-8349
Magnetic fluctuations during fast reconnection in plasma merging experiment

KUWAHATA Akihiro, ITO Taichi, TANABE Hiroshi, INOMOTO Michiaki, ONO Yasushi

プラズマ・核融合学会年会(Web)　29th　2012
磁気リコネクション室内実験の進展

井通暁, 小野靖, 林由記, 田辺博士, 桑波田晃弘

日本天文学会年会講演予稿集　2012　2012

ISSN： 1347-0639
磁気リコネクション実験におけるイオンサイクロトロン周波数帯の磁場揺動の発生

桑波田晃弘, 高博シン, 伊藤大智, 田辺博士, 伊藤慎悟, 井通暁, 小野靖

日本天文学会年会講演予稿集　2012　2012

ISSN： 1347-0639
トーラスプラズマ合体実験を用いた磁気リコネクションのプラズマ加熱機構の検証

田辺博士, 山田琢磨, 岡裕貴, 桑波田晃弘, 案浦正将, 門脇和丈, 神尾修治, SCANNEL Rory, CLIVE Michael, CONWAY Neil, GRYAZNEVICH Mikhail, 井通暁, 小野靖

プラズマ・核融合学会年会(Web)　29th　2012
19pFJ-6 Wave Excitation near the Current Sheet in Magnetic Reconnection Experiment

Inomoto M, Kuwahata A, Gao B, Ono Y

Meeting Abstracts of the Physical Society of Japan　67　(0)　206-206　2012
Publisher: The Physical Society of Japan
DOI： 10.11316/jpsgaiyo.67.2.2.0_206_2 　

ISSN： 1342-8349

eISSN： 2189-0803
Low-frequency magnetic fluctuation measurement during magnetic reconnection in counter-helicity plasma merging experiment

Akihiro Kuwahata, Hiroshi Tanabe, Shingo Ito, Michiaki Inomoto, Yasushi Ono

IEEJ Transactions on Fundamentals and Materials　132　(3)　233-238　2012
Publisher: The Institute of Electrical Engineers of Japan
DOI： 10.1541/ieejfms.132.233 　

ISSN： 0385-4205

eISSN： 1347-5533
Study of Particle Acceleration during Reconnection via TS-4 Particle Trajectory Simulations

PATRICK Copinger, II Toru, HAYASHI Yoshinori, INOMOTO Michiaki, KUWAHATA Akihiro, ONO Yasushi

電気学会基礎・材料・共通部門大会講演論文集(CD-ROM)　2011　2011
Onset of Fast Magnetic Reconnection in Plasma Merging Experiments

INOMOTO Michiaki, HAYASHI Yoshinori, TANABE Hiroshi, KUWAHATA Akihiro, GAO Boxin, ONO Yasushi

プラズマ・核融合学会年会(Web)　28th　2011
Ion Heating Characteristics of Magnetic Reconnection in Torus Plasma Merging Experiment

TANABE Hiroshi, OKA Hirotaka, KUWAHATA Akihiro, ITO Shingo, ANNOURA Masaaki, INOMOTO Michiaki, ONO Yasushi

プラズマ・核融合学会年会(Web)　28th　2011
Generation of Magnetic Fluctuations with Ion Cyclotron Frequency Range during Magnetic Reconnection

KUWAHATA Akihiro, BOXIN Gao, ITO Taichi, TANABE Hiroshi, ITO Shingo, INOMOTO Michiaki, ONO Yasushi

プラズマ・核融合学会年会(Web)　28th　2011
磁気リコネクション実験における低周波磁場揺動の発生

井通暁, 桑波田晃弘, 田辺博士, 伊藤慎悟, 小野靖

日本物理学会講演概要集　66　(1)　2011

ISSN： 1342-8349
26aGY-4 Low frequency magnetic fluctuation in magnetic reconnection experiment

Inomoto M, Kuwahata A, Tanabe H, Ito S, Ono Y

Meeting Abstracts of the Physical Society of Japan　66　(0)　249　2011
Publisher: The Physical Society of Japan
DOI： 10.11316/jpsgaiyo.66.1.2.0_249_4 　

eISSN： 2189-0803
Application of electric double layer capacitor to pulse coil power supply

Keita Abe, Michiaki Inomoto, Takuma Yamada, Akihiro Kuwahata, Shuji Kamio, Morio Sakumura, Qinghong Cao, Ryota Imazawa, Yasushi Ono

IEEJ Transactions on Fundamentals and Materials　131　(1)　55-56　2011
Publisher: The Institute of Electrical Engineers of Japan
DOI： 10.1541/ieejfms.131.55 　

ISSN： 0385-4205

eISSN： 1347-5533
An apical expression signal of the renal type IIc Na⁺-dependent phosphate cotransporter in renal epithelial cells

Mikiko Ito, Aya Sakurai, Keiji Hayashi, Akiko Ohi, Natsumi Kangawa, Takashi Nishiyama, Sakiko Sugino, Yoko Uehata, Akihiro Kamahara, Masae Sakata, Sawako Tatsumi, Masashi Kuwahata, Yutaka Taketani, Hiroko Segawa, Ken-ichi Miyamoto

American Journal of Physiology-Renal Physiology　299　(1)　F243-F254　2010/07
Publisher: American Physiological Society
DOI： 10.1152/ajprenal.00189.2009 　 10.1007/s10157-019-01725-6_references_DOI_EM3tAfwWpD29iia1uRYVb43ngFp 　 10.1080/09168451.2015.1095071_references_DOI_EM3tAfwWpD29iia1uRYVb43ngFp 　 10.1681/asn.2013060569_references_DOI_EM3tAfwWpD29iia1uRYVb43ngFp 　 10.1152/ajpcell.00314.2011_references_DOI_EM3tAfwWpD29iia1uRYVb43ngFp 　 10.4327/jsnfs.64.137_references_DOI_EM3tAfwWpD29iia1uRYVb43ngFp 　 10.2152/jmi.62.209_references_DOI_EM3tAfwWpD29iia1uRYVb43ngFp 　

ISSN： 1931-857X

eISSN： 1522-1466

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<jats:p>The type IIc Na<jats:sup>+</jats:sup>-dependent phosphate cotransporter (NaPi-IIc) is specifically targeted to, and expressed on, the apical membrane of renal proximal tubular cells and mediates phosphate transport. In the present study, we investigated the signals that determine apical expression of NaPi-IIc with a focus on the role of the N- and the C-terminal tails of mouse NaPi-IIc in renal epithelial cells [opossum kidney (OK) and Madin-Darby canine kidney cells]. Wild-type NaPi-IIc, the cotransporter NaPi-IIa, as well as several IIa-IIc chimeras and deletion mutants, were fused to enhanced green fluorescent protein (EGFP), and their cellular localization was analyzed in polarized renal epithelial cells by confocal microscopy and by cell-surface biotinylation. Fluorescent EGFP-fused NaPi-IIc transporter proteins are correctly expressed in the apical membrane of OK cells. The apical expression of N-terminal deletion mutants (deletion of N-terminal 25, 50, or 69 amino acids) was not affected by truncation. In contrast, C-terminal deletion mutants (deletion of C-terminal 45, 50, or 62 amino acids) did not have correct apical expression. A more detailed mutational analysis indicated that a domain (amino acids WLHSL) in the cytoplasmic C terminus is required for apical expression of NaPi-IIc in renal epithelial cells. We conclude that targeting of NaPi-IIc to the apical cell surface is regulated by a unique amino acid motif in the cytoplasmic C-terminal domain.</jats:p>
連続合体を用いた逆転磁場配位の能動的安定化の検証

伊藤慎悟, 伊藤慎悟, 伊井亨, 桑波田晃弘, 井通暁, 小野靖

日本物理学会講演概要集　65　(1)　2010

ISSN： 1342-8349
超高ベータプラズマの電子バーンシュタイン波由来放射波計測

伊神弘恵, 河森栄一郎, 伊藤慎悟, 桑波田晃弘, 小野靖

プラズマ・核融合学会年会(Web)　27th　2010
電流シート放出による高速磁気リコネクション

井通暁, 桑波田晃弘, 田辺博士, 林由記, 小野靖

日本物理学会講演概要集　65　(1)　2010

ISSN： 1342-8349
プラズマ合体装置における磁気リコネクションと低周波波動の励起

桑波田晃弘, 井通暁, 田辺博士, 伊藤慎悟, 小野靖

電気学会全国大会講演論文集　2010　(1)　2010
磁気リコネクション実験における低周波波動の発生と伝搬

井通暁, 桑波田晃弘, 田辺博士, 伊藤慎悟, 小野靖

日本物理学会講演概要集　65　(2)　2010

ISSN： 1342-8349
2次元ドップラー計測を用いた磁気リコネクションのイオン加速・加熱現象の検証

田辺博士, 桑波田晃弘, 岡裕貴, 伊藤慎悟, 井通暁, 小野靖

プラズマ・核融合学会年会(Web)　27th　2010
磁気リコネクション現象における低周波波動の計測

桑波田晃弘, 田辺博士, 岡裕貴, 伊藤慎悟, 井通暁, 小野靖

プラズマ・核融合学会年会(Web)　27th　2010
20aTJ-5 Study of Stabilization effect in Field Reversed Configuration using Continues Merging

Ito Shingo, Ii Toru, Kuwahata Akihiro, Inomoto Michiaki, Ono Yasushi

Meeting Abstracts of the Physical Society of Japan　65　(0)　223-223　2010
Publisher: The Physical Society of Japan
DOI： 10.11316/jpsgaiyo.65.1.2.0_223_3 　

ISSN： 1342-8349

eISSN： 2189-0803
23aTJ-9 Fast Magnetic Reconnection by Current Sheet Ejection

Inomoto M, Kuwahata A, Tanabe H, Hayashi Y, Ono Y

Meeting Abstracts of the Physical Society of Japan　65　(0)　258　2010
Publisher: The Physical Society of Japan
DOI： 10.11316/jpsgaiyo.65.1.2.0_258_2 　

eISSN： 2189-0803
23aTJ-10 Low frequency wave excited by magnetic reconnection in plasma merging experiment

Kuwahata A, Inomoto M, Tanabe H, Ito S, Ono Y

Meeting Abstracts of the Physical Society of Japan　65　(0)　258　2010
Publisher: The Physical Society of Japan
DOI： 10.11316/jpsgaiyo.65.1.2.0_258_3 　

ISSN： 1342-8349

eISSN： 2189-0803
24pQB-5 Excitation and propagation of low frequency waves in magnetic reconnection experiment

Inomoto M, Kuwahata A, Tanabe H, Ito S, Ono Y

Meeting Abstracts of the Physical Society of Japan　65　(0)　187　2010
Publisher: The Physical Society of Japan
DOI： 10.11316/jpsgaiyo.65.2.2.0_187_1 　

eISSN： 2189-0803
Two dimensional ion temperature measurement system by use of multiple line-integrated spectrums

Hiroshi Tanabe, Setthivoine You, Akihiro Kuwahata, Shingo Ito, Michiaki Inomoto, Yasushi Ono

IEEJ Transactions on Fundamentals and Materials　130　(8)　772-773　2010
Publisher: The Institute of Electrical Engineers of Japan
DOI： 10.1541/ieejfms.130.772 　

ISSN： 0385-4205

eISSN： 1347-5533
Planar Processingの基礎的検討~視覚評価・システム分解能の検討~

高倉清悟, 福永智久, 荒井弘之, 高木昭浩, 桑幡浩一, 田中稔, 大屋信義

核医学技術　29　2009

ISSN： 0289-100X
Planar Processingの基礎的検討~物理的特性の検討~

福永智久, 高倉清悟, 荒井弘之, 高木昭浩, 桑幡浩一, 田中稔, 大屋信義

核医学技術　29　2009

ISSN： 0289-100X
プラズマ合体装置における磁気リコネクションとアルヴェン波励起

桑波田晃弘, 井通暁, 田辺博士, 伊藤慎悟, 小野靖

プラズマ・核融合学会年会(Web)　26th　2009
TS-3装置におけるコンパクトトーラスプラズマ合体と高ベータ化

井通暁, 桑波田晃弘, 田辺博士, 伊藤慎悟, 小野靖

プラズマ・核融合学会年会(Web)　26th　2009
Breakdown characteristics of post-discharge phase in discharge produced plasma EUV light source

長野清彦, 安井大貴, 桑波多晃弘, 山本達也, 勝木淳, 佐久川貴志, 秋山秀典

電気学会パルスパワー研究会資料　PPT-08　(65-70)　25-29　2008
Planar processingの基礎的検討-視覚評価による検討-

高倉清悟, 大屋信義, 福永智久, 田中稔, 桑幡浩一, 荒井弘之, 高木昭浩

核医学技術　28　(3)　2008

ISSN： 0289-100X
Planar processingの基礎的検討-物理的特性の検討-

福永智久, 大屋信義, 高倉清悟, 桑幡浩一, 田中稔, 荒井弘之, 高木昭浩

核医学技術　28　(3)　2008

ISSN： 0289-100X
OE-164 Left Atrium Volume Index Related with Pathological Findings as Predictor of Sinus Conversion with Maze Procedure to Atrial Fibrillation patiens(Cardiovascular surgery/CABG-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Kataoka Tetsuro, Hamasaki Shuichi, Ishida Sanemasa, Ogawa Masakazu, Saihara Keishi, Okui Hideki, Oketani Naoya, Ichiki Hitoshi, Ninomiya Yuichi, Kuwahata So, Fujita Shouji, Yuasa Toshinori, Matsushita Takehiko, Inoue Katsumi, Higashi Akihiro, Sakata Ryuzo, Tei Chuwa

Circulation journal : official journal of the Japanese Circulation Society　71　192　2007/03/01
Publisher: Japanese Circulation Society
ISSN： 1346-9843
Correlation between hyperphosphatemia and type II Na-P_i cotransporter activity in klotho mice

Hiroko Segawa, Setsuko Yamanaka, Yasue Ohno, Akemi Onitsuka, Kazuyo Shiozawa, Fumito Aranami, Junya Furutani, Yuka Tomoe, Mikiko Ito, Masashi Kuwahata, Akihiro Imura, Yoichi Nabeshima, Ken-ichi Miyamoto

American Journal of Physiology-Renal Physiology　292　(2)　F769-F779　2007/02
Publisher: American Physiological Society
DOI： 10.1152/ajprenal.00248.2006 　 10.1007/s10157-012-0621-7_references_DOI_STAjXZrQjlZQg5BdVSCzEb3xdAI 　 10.1038/s41581-018-0078-3_references_DOI_STAjXZrQjlZQg5BdVSCzEb3xdAI 　 10.1681/asn.2013060569_references_DOI_STAjXZrQjlZQg5BdVSCzEb3xdAI 　 10.1210/en.2010-1034_references_DOI_STAjXZrQjlZQg5BdVSCzEb3xdAI 　 10.3164/jcbn.17-20_references_DOI_STAjXZrQjlZQg5BdVSCzEb3xdAI 　 10.3389/fendo.2017.00359_references_DOI_STAjXZrQjlZQg5BdVSCzEb3xdAI 　 10.1369/0022155416689670_references_DOI_STAjXZrQjlZQg5BdVSCzEb3xdAI 　 10.1530/joe-17-0683_references_DOI_STAjXZrQjlZQg5BdVSCzEb3xdAI 　 10.2152/jmi.57.95_references_DOI_STAjXZrQjlZQg5BdVSCzEb3xdAI 　 10.2220/biomedres.30.251_references_DOI_STAjXZrQjlZQg5BdVSCzEb3xdAI 　 10.1016/j.bone.2012.01.006_references_DOI_STAjXZrQjlZQg5BdVSCzEb3xdAI 　 10.2183/pjab.85.125_references_DOI_STAjXZrQjlZQg5BdVSCzEb3xdAI 　 10.4327/jsnfs.64.137_references_DOI_STAjXZrQjlZQg5BdVSCzEb3xdAI 　 10.3164/jcbn.23-127_references_DOI_STAjXZrQjlZQg5BdVSCzEb3xdAI 　 10.14814/phy2.14324_references_DOI_STAjXZrQjlZQg5BdVSCzEb3xdAI 　

ISSN： 1931-857X 0363-6127

eISSN： 1522-1466

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<jats:p> Recent studies have demonstrated that klotho protein plays a role in calcium/phosphate homeostasis. The goal of the present study was to investigate the regulation of Na-P<jats:sub>i</jats:sub> cotransporters in klotho mutant (kl/kl) mice. The kl/kl mice displayed hyperphosphatemia, high plasma 1,25(OH)<jats:sub>2</jats:sub>D<jats:sub>3</jats:sub> levels, increased activity of the renal and intestinal sodium-dependent P<jats:sub>i</jats:sub> cotransporters, and increased levels of the type IIa, type IIb, and type IIc transporter proteins compared with wild-type mice. Interestingly, transcript levels of the type IIa/type IIc transporter mRNA abundance, but not transcripts levels of type IIb transporter mRNA, were markedly decreased in kl/kl mice compared with wild-type mice. Furthermore, plasma fibroblast growth factor 23 (FGF23) levels were 150-fold higher in kl/kl mice than in wild-type mice. Feeding of a low-P<jats:sub>i</jats:sub> diet induced the expression of klotho protein and decreased plasma FGF23 levels in kl/kl mice, whereas colchicine treatment experiments revealed evidence of abnormal membrane trafficking of the type IIa transporter in kl/kl mice. Finally, feeding of a low-P<jats:sub>i</jats:sub> diet resulted in increased type IIa Na-P<jats:sub>i</jats:sub> cotransporter protein in the apical membrane in the wild-type mice, but not in kl/kl mice. These results indicate that hyperphosphatemia in klotho mice is due to dysregulation of expression and trafficking of the renal type IIa/IIc transporters rather than to intestinal P<jats:sub>i</jats:sub> uptake. </jats:p>
東海市民病院NST活動の現状~薬剤師の役割

岡戸洋, 山内昭浩, 江口澄子, 小笠原久美子, 桑波田則子, 村瀬千穂, 岩味裕史, 亀岡伸樹

日本医療薬学会年会講演要旨集　15th　2005
Early outcome after sirolimus-eluting stent implantation in patients with chronic renal failure

KUWAHATA Takashi, YAMAGUCHI Hiroshi, TOYOSHIMA Shinichiro, TANAKA Akihiro, KOSHO Yuko, TOYAMA Yoshifumi

Japanese Journal of Interventional Cardiology　20　(Supplement 1)　2005

ISSN： 0914-8922
Impact of early lumen loss after balloon angioplasty for in-stent restenosis on lumen loss at follow-up; Serial volumetric IVUS analysis

FURUSYO Yuko, YAMAGUCHI Hiroshi, TOYOSHIMA Shinichiro, TANAKA Akihiro, KUWAHATA Takashi, TOYAMA Yoshifumi

Japanese Journal of Interventional Cardiology　20　(Supplement 1)　2005

ISSN： 0914-8922
Radius Stent留置後の病変部拡張様式-IVUS所見からの検討-

桑波田隆志, 山口浩士, 豊島慎一郎, 田中昭浩, 原田信哉, 清永和明, 外山芳史, 鄭忠和

Japanese Journal of Interventional Cardiology　18　(Supplement 1)　2003

ISSN： 0914-8922
冠動脈ステントは長期的にみて安全か~POBAとの比較~

豊島慎一郎, 山口浩士, 田中昭浩, 桑波田隆志, 原田信哉, 清永和明, 外山芳史, 鄭忠和

Japanese Journal of Interventional Cardiology　18　(Supplement 1)　2003

ISSN： 0914-8922
カンキツ新品種‘かごしま早生’の特性

岩田浩二, 西元直行, 東明弘, 児玉香, 川田原千鶴, 桑波田龍沢

鹿児島県果樹試験場研究報告　(3)　2001

ISSN： 1343-8778
極早生温州新品種「かごしま早生」の特性

岩田浩二, 西元直行, 東明弘, 児玉香, 川田原千鶴, 桑波田龍沢

九州沖縄農業研究成果情報　(16)　2001

ISSN： 1346-7603
カンキツ新品種‘かごしま早生’の特性

岩田浩二, 西元直行, 東明弘, 児玉香, 川田原千鶴, 桑波田龍沢

園芸学会雑誌別冊　69　(2)　2000

ISSN： 0919-1917
造影剤により遅発性間質性肺炎を発症したと思われる4症例

川田英明, 山口浩士, 豊嶋慎一郎, 田中昭浩, 桑波田隆志, 溝口悦子, 清永和明, 外山芳史, 鄭忠和

Japanese Circulation Journal　64　(Supplement 3)　2000

ISSN： 0047-1828
恒久的ペースメーカーリードに血栓形成をきたしたアミロイドーシスの1症例

田中昭浩, 豊島慎一郎, 川島英明, 桑波田隆志, 溝口悦子, 清永和明, 外山芳史, 山口浩士, 鄭忠和

Japanese Circulation Journal　64　(Supplement 3)　2000

ISSN： 0047-1828
Characteristics of a new citrus cultivar ‘Sasshu’.

東明弘, 岩田浩二, 桑波田龍沢, 児玉香, 時任俊広, 寺田悟志, 有薗重美, 宮迫一郎

鹿児島県果樹試験場研究報告　(2)　1999

ISSN： 1343-8778
Fruit quality of new citrus cultivar ’Sasshuu’.

東明弘, 岩田浩二, 桑波田龍沢, 児玉香

園芸学会雑誌別冊　66　(2)　1997

ISSN： 0919-1917
Characteristics of ”Hetsuka Daidai” and the selection of promising strains.

東明弘, 桑波田龍沢

園芸学会雑誌別冊　64　(1)　1995

ISSN： 0919-1917
Characteristics of ’Hetsuka Daidai’ and the Selection of Promising Strains.

東明弘, 桑波田龍沢

九州農業研究　(57)　1995

ISSN： 0451-1581
Characteristics of ‘Hetsuka Daidai’ and the selection of promising strains.

東明弘, 桑波田龍沢

園芸学会九州支部研究集録　(3)　1994
Electro Fusion of Satsuma Mandarin Protoplast.

東明弘, 桑波田竜沢

九州農業研究　(54)　1992

ISSN： 0451-1581
Repair of the pressure sore with musculocutaneous flap.

林田一夫, 谷口良康, 益崎浩治, 田中源郎, 日高恒彦, 桑畑昭洋, 新村竜夫

整形外科と災害外科　31　(4)　1983

ISSN： 0037-1033
厚板圧延工程へのインラインガスカッター(IGC)の導入

日渡せい朗, 中間昭洋, 奥公夫, 桑畑明弘, 松本聖たか, 河野幸三

鉄と鋼　67　(12)　1981

ISSN： 0021-1575

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Books and Other Publications 2

Nanomagnetic materials : fabrication, characterization and application

Yamaguchi, Akinobu, Hirohata, Atsufumi, Stadler, J.H. Bethanie

Elsevier　2021

ISBN: 9780128223499
Cancers, Special issue “Prospects from Diagnosis to Treatment in Cancer Using Magnetic Methods”

Cancers, Special issue, “Prospects from Diagnosis to Treatment in Cancer, Using Magnetic Methods”, Reprin, https, www.mdpi.com, books, boo, rospects-from-diagnosis-to-treatment-in-cancer-using-magnetic-methods

Presentations 5

Magnetic nanoparticle detection by utilizing nonlinear magnetization for sentinel lymph nodes of breast cancer patients

A. Kuwahata, K. Taruno, T. Kurita, M. Makita, S. Chikaki, I. Saito, H. Takei, S. Nakamura, M. Kusakabe, and M. Sekino

The International Magnetics Conference (INTERMAG 2020)
Cavity-shaped magnet for highly sensitive magnetic detection of magnetic nanoparticles in breast cancer patients

A. Kuwahata, M. Kusakabe, S. Chikaki, I. Saito, M. Sekino

64th Annual Conference on Magnetism and Magnetic Materials　2019/12/07
Magnetometer for laparoscopic detection of magnetic nanoparticles in sentinel lymph nodes for gastric cancer patients

A. Kuwahata, R. Tanaka, S. Matsuda, E. Amada, T. Irino, S. Mayanagi, S. Isaka, S. Chikaki, I. Saito, N. Tanabe, H. Kawakubo, H. Takeuchi, Y. Kitagawa, M. Kusakabe, M. Sekino

40th International Conference of the IEEE Engineering in Medicine and Biology Society　2019/07
Handheld magnetic probe with permanent magnet and Hall sensor for identifying sentinel lymph nodes in breast cancer patients

A. Kuwahata, M. Sekino, T. Ookubo, M. Shiozawa, K. Ohashi, M. Kaneko, I. Saito, Y. Inoue, H. Ohsaki, H. Takei, M. Kusakabe

21st International Conference on Biomagnetism (BIOMAG2018)　2018/08/26
Diamond NV Magnetometer for Detecting Magnetic Nanoparticles in Rat Lymph Nodes

A. Kuwahata, T. Kitaizumi, K. Saichi, T. Sato, R. Igarashi, T. Ohsima, Y. Masuyama, T. Iwasaki, M. Hatano, F. Jelezko, M. Kusakabe, T. Yatsui, M. Sekino

The 2nd International Forum on Quantum Metrology and Sensing

Industrial Property Rights 8

反応促進装置及び反応促進方法

関野正樹, 隣真一, 金子美樹, 桑波田晃弘, 松田祐子, 坂本聡, 日下部守昭

特許6420433

Property Type: Patent
反応促進装置及び反応促進方法

関野正樹, 隣真一, 金子美樹, 桑波田晃弘, 松田祐子, 坂本聡, 日下部守昭

特許6370018

Property Type: Patent
反応促進装置及び反応促進方法

関野正樹, 隣真一, 金子美樹, 桑波田晃弘, 松田祐子, 坂本聡, 日下部守昭

特許6370017

Property Type: Patent
MAGNETIC BODY DETECTING DEVICE

Akihiro Kuwahata, Moriaki Kusakabe, Masaki Sekino

Property Type: Patent
マーカー位置確認方法及び磁気測定装置

関野正樹, 桑波田晃弘, オインデレラ, ボーミックデブナート, 金子美樹, 日下部守昭

Property Type: Patent
MAGNETIC SUBSTANCE QUANTIFICATION DEVICE AND MANUFACTURING METHOD THEREOF

Akihiro Kuwahata, Masaki Sekino, Miki Kaneko, Shinichi Shikaki, Moriaki Kusakabe

Property Type: Patent
磁気遮蔽システム及び磁気遮蔽方法

関野正樹, 金世旭, 桑波田晃弘, 隣真一

Property Type: Patent
磁性体定量装置及びその製造方法

関野正樹, 桑波田晃弘, 金子美樹, 隣真一, 日下部守昭

特許第6268325号

Property Type: Patent

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Research Projects 5

Multimodal cancer therapy and diagnostic system using 256-channel diamond quantum sensor array

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2023/04/01 - 2026/03/31
https://www.amed.go.jp/koubo/12/01/1201C_00047.html

Category: https://www.amed.go.jp/koubo/12/01/1201C_00047.html

2023/06 - 2025/03
ナノ光電磁場による太陽光ウイルス不活性化とその応用技術の開発

八井崇

Offer Organization: 科学技術振興機構

System: 産学が連携した研究開発成果の展開研究成果展開事業研究成果最適展開支援プログラム(A-STEP) 産学共同(育成型)

Institution: 国立大学法人豊橋技術科学大学

2021 - 2021

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with/postコロナ社会に備えた電源フリーなウイルス不活性化および高感度ウイルス検出技術の開発を行う。近接場光の空間的に非一様な光の場の特長を活かすことで、従前の光応答では不可能であった新規かつ有用な光励起が可能であることを実証してきた。本研究では、[1]この近接場光による短波長化の性質を利用することで、太陽光によるウイルス不活性化を実証する。太陽を光源とするウイルス不活性化は、電源フリーのため普及にも繋がり、応用性は非常に高い。[2]ダイヤモンド窒素-空孔センター含有のナノ構造体がウイルスと結合することで微小な磁場の差異を発生させることを利用し、ウイルスのリアルタイム迅速検出技術を確立する。
Development of super-resolution MRI using near-field induced active contrast control

Yatsui Takashi, SEKINO masaki, KUWAHATA akihiro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Challenging Research (Exploratory)

Institution: The University of Tokyo

2017/06/30 - 2019/03/31

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It is expected that the control the magnetic field at micro wave range for MRI application results in super resolution of MRI images. In this study, we have investigated the structures which can focus the micro wave range. In though the simulations, we found the optimum structure to enhance the magnetic field. In addition, we confirmed the designed structure resulted in the magnetic field enhancement. Finally, we succeeded to confirm the fabricated structure resulted in the improvement of the contrast in the MRI images.
Heating and flow drive by low frequency waves in high beta plasmas

INOMOTO Michiaki, KAMIO Shuji, II Toru, KUWAHATA Akihiro, ITAGAKI Hirotomo, WATANABE Takenori, YAMASAKI Kotaro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Young Scientists (A)

Institution: The University of Tokyo

2010/04/01 - 2014/03/31

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Low frequency waves are excited in the high beta region of magnetically confined plasmas by magnetic reconnection during plasma merging process. These waves partly contribute to the conversion from magnetic energy to ion thermal energy. When the reconnection includes significant guide magnetic field perpendicular to the reconnection magnetic field, monotonic large-amplitude waves are excited as kinetic Alven waves. However, these waves are not dominant factors providing the observed ion heating. On the other hand, when there is no guide field, very low fewquency waves are globally excited. These shear Alfven waves directly drive ion flows and eventually provide conversion from magnetic to ion thermal energy. It is concluded that these very low frequency waves work for the heating method for high beta plasmas.

Teaching Experience 3

学生実験C
電気回路学基礎演習
電気回路学基礎論