Details of the Researcher

PHOTO

Eijiro Miyako
Section
Institute of Multidisciplinary Research for Advanced Materials
Job title
Professor
Degree

  • PhD in Engineering (Kyushu University)

e-Rad No.
70443231
Profile

大分県出身。九州大学大学院工学研究科博士課程修了(化学システム工学)。工学博士。専門は、生物工学、材料化学、ナノテクノロジー、ナノメディシン。とりわけ「革新的がん診断・治療技術の創出」を目指した材料とバイオを使ったゲームチェンジングテクノロジーを生み出すべく、様々な研究手法を組み合わせた学際的研究を進めています。

Research History 12

  • 2026/04 - Present
    Tohoku University　Professor

  • 2026/04 - Present
    Japan Advanced Institute of Science and Technology　Guest Professor

  • 2024/10 - 2026/03
    Japan Advanced Institute of Science and Technology　Advisor to the president

  • 2024/10 - 2026/03
    Japan Advanced Institute of Science and Technology　Professor

  • 2019/07 - 2024/09
    Japan Advanced Institute of Science and Technology　Associate Professor

  • 2021/04 - 2023/03
    Japan Advanced Institute of Science and Technology　Research Core for Exponential-Biomedical Engineering　Research Director

  • 2019/07 - 2020/09
    National Institute of Advanced Industrial Science and Technology (AIST)　Guest Researcher

  • 2013/03 - 2019/06
    National Institute of Advanced Industrial Science and Technology (AIST)　Senior Researcher

  • 2017/12 - 2018/12
    Nanyang Technological University (NTU)　Visiting Scientist

  • 2012/10 - 2013/10
    Centre national de la recherche scientifique (CNRS)　Visiting Scientist

  • 2006/04 - 2013/02
    National Institute of Advanced Industrial Science and Technology (AIST)　Researcher

  • 2005/04 - 2006/03
    Japan Society for the Promotion of Science (JSPS)　Research Fellow

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Education 3

  • Kyushu University　Faculty of Engineering　PhD Course, Department of Chemical Systems and Engineering

    2004/04 - 2006/03

  • Kyushu University　Faculty of Engineering　Master's Course, Department of Chemical Systems and Engineering

    2002/04 - 2004/03

  • Kagoshima University　Department of Engineering　Applied Chemistry and Chemical Engineering

    1998/04 - 2002/03

Committee Memberships 4

  • Advanced Oncology (Wiley)　Editorial Advisory Board

    2026/09 - Present

  • Small Science (Wiley)　Editorial Advisory Board

    2025/11 - Present

  • Cell Reports Physical Science (Cell Press)　Advisory board

    2025/10 - Present

  • iScience (Cell Press)　Advisory board

    2019/10 - Present

Professional Memberships 3

  • The Society for Biotechnology, Japan

  • THE SOCIETY OF POLYMER SCIENCE, JAPAN

  • THE CHEMICAL SOCIETY OF JAPAN

Research Interests 8

  • Drug Discovery

  • Bacteria

  • Cancer

  • Drug Delivery System

  • Biotechnology

  • Bio-functional materials

  • Nanomaterials

  • Nanobio

Research Areas 4

  • Nanotechnology/Materials / Biochemistry /

  • Life sciences / Biomaterials /

  • Life sciences / Biomedical engineering /

  • Nanotechnology/Materials / Nanomaterials /

Awards 14

  1. Innovation Award

    2026　Tech Startup HOKURIKU (TeSH)

  2. "Changing Tomorrow" Pitch Competition

    2026　LINK-J and Astellas Pharma Inc.　Winner

  3. Best Seed Science Award

    2025　NINEJP

  4. Finalist

    2025　Science to Startup (S2S) Japan

  5. Prof. Sumio Iijima Research Encouragement Award

    2015　The 47th Fullerenes-Nanotubes-Graphene General Symposium

  6. Best Poster Award

    2014　NIMS conference 2014

  7. PCCP Prize 2014

    2014　Royal Society of Chemistry

  8. Kao Encouragement Award in Chemistry and Physics

    2012　The Kao Foundation for Arts and Sciences

  9. Young Scientist Lecture Award

    2011　The 57th Polymer Research Symposium

  10. Young Scientist Lecture Award

    2011　The 91st Spring Meeting of The Chemical Society of Japan

  11. Young Scientist Award

    2009　The 1st FAPS Polymer Congress

  12. Award of Excellence

    2006　The 1st International Symposium on Functional Innovation of Molecular Informatics

  13. Student Competition Award

    2005　Pacifichem 2005

  14. International Session Student Award

    2005　The 35th Annual Meeting of the Society of Separation Process Engineers

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Papers 93

  1. Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy Invited Peer-reviewed

    Nina Sang, Eijiro Miyako

    Advanced Science　e77069　2026/08/11

    Publisher: Wiley

    DOI： 10.1002/advs.77069 　

    ISSN： 2198-3844

    eISSN： 2198-3844

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    ABSTRACT Triple‐negative breast cancer (TNBC) remains highly lethal due to aggressive metastasis and profound immunosuppression by regulatory T cells (Tregs). Here, we present a biomimetic liquid metal (LM)‐based photothermal immunotherapeutic nanoplatform exploiting gallium‐based LMs to orchestrate cascade amplification of antitumor immunity. The engineered nanoplatform (B–LM–DMX–αCD25) integrates an LM photothermal core with dual immunomodulatory components—anti‐CD25 antibody for Treg depletion and stimulator of interferon genes (STING) agonist 5,6‐dimethylxanthenone‐4‐acetic acid (DMX) for innate immune activation—while blood‐derived camouflaging enhances immune evasion and tumor accumulation. Quantitative RT‐PCR of 13 immune‐related genes confirmed STING engagement, robust CD8+ cytotoxic T‐cell infiltration, and Treg depletion in treated tumors. This platform operates through three synchronized mechanisms: (1) selective intratumoral Treg depletion dismantling immunosuppression; (2) near‐infrared‐triggered LM‐mediated photothermal therapy (58°C within 5 min) inducing immunogenic cell death and releasing tumor‐associated antigens; and (3) STING pathway activation promoting dendritic cell maturation and tumor‐specific cytotoxic T‐cell responses, collectively transforming immunologically “cold” TNBC into immune‐responsive tumors. In orthotopic 4T1 models, the nanoplatform achieves significant tumor regression with enhanced survival, while in metastatic models, it reduces pulmonary metastatic nodules and extends median survival beyond 70 days. This work establishes a paradigm‐shifting biomimetic LM‐based nanodelivery strategy addressing fundamental immunological barriers in TNBC through coordinated photothermal–immunotherapy, offering a clinically translatable approach for TNBC.

  2. Intrinsically Disordered Polypeptides-Based Stealth Materials Enable Enhanced Photothermal Cancer Therapy Using an In Situ Fiber-Based Penetrating Laser System Invited Peer-reviewed

    Kei Nishida, Hiromasa Yamashita, Akira Takahashi, Eijiro Miyako

    Small Science　6　(7)　e70342　2026/07

    DOI： 10.1002/smsc.70342Digital 　

  3. Sustainable Polylactic Acid-Derived Polyurethane/MXene Microneedles for Stimulus-Responsive Transdermal Delivery Peer-reviewed

    Oceu D. Putri, Atitsa Petchsuk, Kensuke Asukabe, Nagi Yamashita, Eijiro Miyako, Pakorn Opaprakasit, Kazuaki Matsumura

    ACS Polymers Au　6　(4)　1175-1191　2026/05/31

    Publisher: American Chemical Society (ACS)

    DOI： 10.1021/acspolymersau.6c00060 　

    ISSN： 2694-2453

    eISSN： 2694-2453

  4. Multifunctional amino acid-based nanoparticles for sequential drug delivery to overcome multidrug resistant cancer Peer-reviewed

    Tengfei Wang, Nina Sang, Cécilia Ménard-Moyon, Eijiro Miyako, Alberto Bianco

    Journal of Controlled Release　395　(10)　114954　2026/04

    Publisher: Elsevier BV

    DOI： 10.1016/j.jconrel.2026.114954 　

    ISSN： 0168-3659

  5. Tumour-resident oncolytic bacteria trigger potent anticancer effects through selective intratumoural thrombosis and necrosis Peer-reviewed

    Seigo Iwata, Taisei Nishiyama, Matomo Sakari, Yuki Doi, Naoki Takaya, Yusuke Ogitani, Hiroshi Nagano, Keisuke Fukuchi, Eijiro Miyako

    Nature Biomedical Engineering　10　293-308　2026

    DOI： 10.1038/s41551-025-01459-9 　

  6. Discovery and characterization of antitumor gut microbiota from amphibians and reptiles: Ewingella americana as a novel therapeutic agent with dual cytotoxic and immunomodulatory properties Peer-reviewed

    Seigo Iwata, Nagi Yamasita, Kensuke Asukabe, Matomo Sakari, Eijiro Miyako

    Gut Microbes　17　(1)　2599562　2025/12/10

    Publisher: Informa UK Limited

    DOI： 10.1080/19490976.2025.2599562 　

    ISSN： 1949-0976

    eISSN： 1949-0984

  7. Systemic administration of Photobacterium angustum promotes antitumor immunity and direct tumor lysis in murine models of colorectal cancer Peer-reviewed

    Mikako Miyahara, Teruhisa Takizawa, Matomo Sakari, Eijiro Miyako

    Journal for ImmunoTherapy of Cancer　13　e012665　2025/11

  8. Bacterial-adjuvant liquid metal nanocomposites for synergistic photothermal immunotherapy Peer-reviewed

    Nina Sang, Seigo Iwata, Yun Qi, Eijiro Miyako

    Advanced Composites and Hybrid Materials　8　353　2025/09

  9. Carbon nanohorn coating on titanium promotes M2 macrophage polarization Peer-reviewed

    Sadahito KIMURA, Eri HIRATA, Yuta TAKANO, Miho IBI, Natsumi USHIJIMA, Eijiro MIYAKO, Masako YUDASAKA, Yukari MAEDA, Daisuke KONISHI, Kiwamu SAKAGUCHI, Atsuro YOKOYAMA

    Dental Materials Journal　44　(5)　564-571　2025/09

    Publisher: Japanese Society for Dental Materials and Devices

    DOI： 10.4012/dmj.2025-028 　

    ISSN： 0287-4547

    eISSN： 1881-1361

  10. A Next-Generation Brain-Targeting Peptide: KS-487 Rivals Angiopep-2 in BBB Penetration with Enhanced Selectivity Peer-reviewed

    Kensuke Asukabe, Nagi Yamashita, Runa Fujimoto, Kotaro Sakamoto, Eijiro Miyako

    Bioconjugate Chemistry　36　2124-2131　2025/09

  11. Living drugs: A wonderful evolution for therapeutic applications Peer-reviewed

    Soudamini Chintalapati, Nina Sang, Mikako Miyahara, Seigo Iwata, Kei Nishida, Eijiro Miyako

    Cell Biomaterials　1　(10)　100193　2025/09

    DOI： 10.1016/j.celbio.2025.100193 　

  12. Reply to “Exploring Bacteria‐Based Cancer Immunotherapy”—Comment on “Discovery of Intratumoral Oncolytic Bacteria Toward Targeted Anticancer Theranostics” Peer-reviewed

    Eijiro Miyako

    Advanced Science　12　(30)　e11325　2025/07/14

    Publisher: Wiley

    DOI： 10.1002/advs.202511325 　

    ISSN： 2198-3844

    eISSN： 2198-3844

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    Abstract This manuscript is a formal response to the commentary by A/Prof. Dr. Chen‐xi Li and colleagues regarding our previous publication in Advanced Science. We clarify the rationale, methods, and outcomes of our original study and highlight ongoing work in the field of bacterial cancer immunotherapy.

  13. Hybrid Nanoarchitectonics with Bacterial Component-Integrated Graphene Oxide for Cancer Photothermo-Chemo-Immunotherapy Peer-reviewed

    Soudamini Chintalapati, Eijiro Miyako

    Carbon　238　120252-120252　2025/03

    Publisher: Elsevier BV

    DOI： 10.1016/j.carbon.2025.120252 　

    ISSN： 0008-6223

  14. Multifunctional Magnetic Ionic Liquid-Carbon Nanohorn Complexes for Targeted Cancer Theranostics Peer-reviewed

    Yun Qi, Eijiro Miyako

    Small Science　5　2400640　2025/03

    DOI： 10.1002/smsc.202400640 　

  15. Photocatalytic scaffolds enhance anticancer performances of bacterial consortium AUN Peer-reviewed

    Mikako Miyahara, Yuki Doi, Naoki Takaya, Eijiro Miyako

    Chemical Engineering Journal　499　156378　2024/10

    Publisher: Elsevier BV

    DOI： 10.1016/j.cej.2024.156378 　

    ISSN： 1385-8947

  16. Wireless Light‐Emitting Diode‐Driven Functional Microneedle Devices for Skin Cancer Therapy Peer-reviewed

    Miranda Oungeun, Supason Wanichwecharungruang, Eijiro Miyako

    Advanced Therapeutics　7　2024/09/27

    Publisher: Wiley

    DOI： 10.1002/adtp.202400233 　

    ISSN： 2366-3987

    eISSN： 2366-3987

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    Abstract Photodynamic therapy, a noninvasive cancer treatment strategy, is a promising remedy for malignant skin cancers. However, treatment of skin cancer with this method requires sufficient photosensitizer molecules to permeate into cancer cells before illumination for effective activation to induce potent reactive oxygen species for eliminating cancer cells. However, transdermal drug delivery using conventional photosensitizers faces major challenges due to skin barriers, diminishing the effectiveness of drug penetration and therapeutic efficacies. To overcome these limitations, biocompatible, physiologically dissolvable, and optically activatable functional microneedle devices are applied for effective percutaneous penetration of drug molecules into solid tumors in a murine model. The proposed wireless light‐emitting diode light‐driven functional microneedle device that effectively induces apoptosis of cancer cells and disruption of the tumor area and can enhance in vitro, ex vivo, and in vivo drug‐delivery effectiveness for treating skin cancer. The design and strategy of the present functional microneedle devices can help shed light on future advanced cancer therapy.

  17. KS‐133/KS‐487 Nanoparticles Exhibit Potent Antitumor Effects through Synergistic LRP1 Targeting and VIPR2 Inhibition: Therapeutic Nanoarchitectonics for Solid Tumors Peer-reviewed

    Kotaro Sakamoto, Taisei Nishiyama, Eijiro Miyako

    Advanced Therapeutics　7　2400278　2024/08

    Publisher: Wiley

    DOI： 10.1002/adtp.202400278 　

    ISSN： 2366-3987

    eISSN： 2366-3987

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    Abstract VIPR2 is associated with psychiatric disorders, breast cancer metastasis, and cancer immunostimulation. The VIPR2 antagonist KS‐133 changes the polarity of macrophages to the M1 type, and nanoparticles (NPs) releasing KS‐133 exhibit antitumor effects against mouse colon cancer cells (CT26) in vivo. To enhance the antitumor effect of KS‐133 NPs, KS‐133 NPs are combined with the peptide KS‐487 targeting LRP1, which is expressed on CT26 cells. Subcutaneous injection of NPs containing indocyanine green (ICG) fluorescent dye and presenting KS‐487 in CT26 subcutaneous tumor‐bearing mice resulted in significant accumulation of ICG in the CT26 tumor compared to administration of NPs without KS‐487. NPs containing KS‐133 and presenting KS‐487 (KS‐133/KS‐487 NPs) exhibited dose‐dependent antitumor effects in CT26 subcutaneous tumor‐bearing mice; the antitumor effects are more potent than the effects of KS‐133 NPs without KS‐487. In addition, CD8‐positive T cells and macrophages significantly infiltrated into CT26 tumors after injection of KS‐133/KS‐487 NPs. Thus, KS‐133/KS‐487 NPs efficiently deliver KS‐133 to CT26 tumors via LRP1‐targeting and activate immune system cells such as CD8 positive T cells and macrophages via KS‐133 inhibition of VIPR2 signaling, resulting in antitumor effects. These results demonstrate the potential of KS‐133/KS‐487 NPs as a therapeutic candidate for treating solid tumors.

  18. Biomimetic Functional Nanocomplexes for Photothermal Cancer Chemoimmunotheranostics Peer-reviewed

    Nina Sang, Yun Qi, Shun Nishimura, Eijiro Miyako

    Small Science　4　2400324　2024/08

    DOI： 10.1002/smsc.202400324 　

  19. Liquid metal-polymer nano-microconjugations as an injectable and photo-activatable drug carrier Peer-reviewed

    Tomoka Hirose, Robin Rajan, Eijiro Miyako, Kazuaki Matsumura

    Molecular Systems Design & Engineering　9　(7)　781-789　2024/07/01

    DOI： 10.1039/d4me00028e 　

    ISSN： 2058-9689

  20. Cyclic Peptides KS-133 and KS-487 Multifunctionalized Nanoparticles Enable Efficient Brain Targeting for Treating Schizophrenia Peer-reviewed

    Kotaro Sakamoto, Seigo Iwata, Zihao Jin, Lu Chen, Tatsunori Miyaoka, Mei Yamada, Kaiga Katahira, Rei Yokoyama, Ami Ono, Satoshi Asano, Kotaro Tanimoto, Rika Ishimura, Shinsaku Nakagawa, Takatsugu Hirokawa, Yukio Ago, Eijiro Miyako

    JACS Au　4　(8)　2811-2817　2024/06/20

    Publisher: American Chemical Society (ACS)

    DOI： 10.1021/jacsau.4c00311 　

    ISSN： 2691-3704

    eISSN： 2691-3704

  21. Tumor-isolated Cutibacterium acnes as an effective tumor suppressive living drug Peer-reviewed

    Soudamini Sai Vimala Veera Chintalapati, Seigo Iwata, Mikako Miyahara, Eijiro Miyako

    Biomedicine & Pharmacotherapy　170　116041-116041　2024/01

    Publisher: Elsevier BV

    DOI： 10.1016/j.biopha.2023.116041 　

    ISSN： 0753-3322

  22. Photocrosslinked Co‐Assembled Amino Acid Nanoparticles for Controlled Chemo/Photothermal Combined Anticancer Therapy Peer-reviewed

    Tengfei Wang, Yun Qi, Eijiro Miyako, Alberto Bianco, Cécilia Ménard‐Moyon

    Small　20　2307337　2023/12

    Publisher: Wiley

    DOI： 10.1002/smll.202307337 　

    ISSN： 1613-6810

    eISSN： 1613-6829

  23. Cancer immunotheranostics using bioactive nanocoated photosynthetic bacterial complexes Peer-reviewed

    Sheethal Reghu, Seigo Iwata, Satoru Komatsu, Takafumi Nakajo, Eijiro Miyako

    Nano Today　52　101966　2023/08

  24. Light‐Activatable Liquid Metal Immunostimulants for Cancer Nanotheranostics Invited Peer-reviewed

    Yun Qi, Mikako Miyahara, Seigo Iwata, Eijiro Miyako

    Advanced Functional Materials　34　(31)　2305886　2023/07/28

    Publisher: Wiley

    DOI： 10.1002/adfm.202305886 　

    ISSN： 1616-301X

    eISSN： 1616-3028

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    Abstract Gallium‐based liquid metal (LM) nanoparticles are among the most promising nanoscale materials for biomedicinal applications because of their outstanding physicochemical properties, including unique flexibility, easy surface modification, excellent photothermal conversion efficiency, and high biocompatibility. Further exploration of the modification and remote‐controlling performances of LM nanoparticles with functional bioactive molecules for the development of an innovative treatment modality for diseases is challenging. Herein, it is reported that near‐infrared (NIR) light‐activatable LM nanoparticle, which functionalized with immunological activators of T and dendritic cells, can work as highly immunogenic and photo‐exothermic nanoscale stimulants for cancer treatment. The synthesized LM nanostimulant, which has low toxicity, powerful photothermal conversion property, and high immunogenic features, can effectively eliminate cancer cells, cancer spheroids, and colorectal tumors in living mice under NIR laser illumination. Moreover, the fluorescent LM nanostimulant can express strong fluorescence as a reporter agent to identify the targeted tumors in living mice for optical cancer diagnosis. Therefore, such a smart nanostimulant represents a way toward combination photothermal immunotheranostics.

  25. Discovery of Intratumoral Oncolytic Bacteria Toward Targeted Anticancer Theranostics Peer-reviewed

    Yamato Goto, Seigo Iwata, Mikako Miyahara, Eijiro Miyako

    Advanced Science　10　(20)　2301679　2023/05/07

    Publisher: Wiley

    DOI： 10.1002/advs.202301679 　

    ISSN： 2198-3844

    eISSN： 2198-3844

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    Abstract Unveiling biomedical functions of tumor‐resident microbiota is challenging for developing advanced anticancer medicines. This study demonstrates that isolated intratumoral bacteria, associated with natural purple photosynthetic bacteria, have inherent biocompatibility and strong immunogenic anticancer efficacies. They preferentially grow and proliferate within a targeted tumor milieu, which effectively causes immune cells to infiltrate the tumor and provoke strong anticancer responses in various syngeneic mouse models, including colorectal cancer, sarcoma, metastatic lung cancer, and extensive drug‐resistant breast cancer. Furthermore, these functional bacteria‐treated mice exhibit excellent anticancerous responses and have significantly prolonged survival rates with effective immunological memory. Light‐harvesting nanocomplexes of microbial consortia of intratumoral bacteria and purple photosynthetic bacteria can diagnose tumors using bio‐optical‐window near‐infrared light, making them useful theranostic agents for highly targeted immunological elimination of the tumor and for precisely marking tumor location.

  26. The VIPR2-selective antagonist KS-133 changes macrophage polarization and exerts potent anti-tumor effects as a single agent and in combination with an anti-PD-1 antibody International-journal Peer-reviewed

    Kotaro Sakamoto, Wararat Kittikulsuth, Eijiro Miyako, Akumwami Steeve, Rika Ishimura, Shinsaku Nakagawa, Yukio Ago, Akira Nishiyama

    PLOS ONE　18　(7)　e0286651　2023

    DOI： 10.1371/journal.pone.0286651 　

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    We have previously demonstrated that KS-133 is a specific and potent antagonist of vasoactive intestinal peptide receptor 2 (VIPR2). We have also shown that vasoactive intestinal peptide-VIPR2 signaling affects the polarity and activation of tumor-associated macrophages, which is another strategy for cancer immunotherapy apart from the activation of effector T cells. In this study, we aimed to examine whether the selective blockade of VIPR2 by KS-133 changes the polarization of macrophages and induces anti-tumor effects. In the presence of KS-133, genetic markers indicative of tumor-aggressive M1-type macrophages were upregulated, and conversely, those of tumor-supportive M2-type macrophages were downregulated. Daily subcutaneous administration of KS-133 tended to suppress the growth of CT26 tumors (murine colorectal cancer-derived cells) implanted subcutaneously in Balb/c mice. To improve the pharmacological efficacy and reduce the number of doses, we examined a nanoformulation of KS-133 using the US Food and Drug Administration-approved pharmaceutical additive surfactant Cremophor® EL. KS-133 nanoparticles (NPs) were approximately 15 nm in size and stable at 4°C after preparation. Meanwhile, KS-133 was gradually released from the NPs as the temperature was increased. Subcutaneous administration of KS-133 NPs once every 3 days had stronger anti-tumor effects than daily subcutaneous administration of KS-133. Furthermore, KS-133 NPs significantly enhanced the pharmacological efficacy of an immune checkpoint-inhibiting anti-PD-1 antibody. A pharmacokinetic study suggested that the enhancement of anti-tumor activity was associated with improvement of the pharmacokinetic profile of KS-133 upon nanoformulation. Our data have revealed that specific blockade of VIPR2 by KS-133 has therapeutic potential for cancer both alone and in combination with immune checkpoint inhibitors.

  27. Nanoformulation of the K-Ras(G12D)-inhibitory peptide KS-58 suppresses colorectal and pancreatic cancer-derived tumors Peer-reviewed

    Kotaro Sakamoto, Yun Qi, Eijiro Miyako

    Scientific Reports　13　(1)　518　2023/01

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-023-27825-8 　

    eISSN： 2045-2322

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    Abstract Single amino acid mutations of Ras occur in 30% of human cancers. In particular, K-Ras(G12D) has been detected in the majority of intractable colorectal and pancreatic cancers. Although efforts to target K-Ras(G12D) are currently underway, no effective drugs are available. We previously found that the K-Ras(G12D)-inhibitory bicyclic peptide KS-58 exhibits antitumor activity against syngeneic colon and orthotopic grafted pancreatic tumors; however, pristine KS-58 is difficult to handle because of low water solubility and it requires frequent administration to obtain sufficient antitumor activity. In this study, we used a nanoformulation of KS-58 prepared with the highly biocompatible surfactant Cremophor® EL (CrEL) to improve water solubility and reduce the dosing frequency. Nanoformulations of KS-58 with CrEL dramatically improved its water solubility and increased its stability. Weekly intravenous administration of KS-58 nanoparticles (NPs) suppressed the growth of CT26 and PANC-1 cell-derived tumors in vivo, and fluorescent bioimaging indicated that the NP-encapsulated near-infrared fluorescent probe indocyanine green selectively accumulated in the tumor and was safely excreted through the kidneys following intravenous injection. Histopathological analysis of CT26 tumors and Western blotting of PANC-1 tumors revealed that KS-58 NPs reduced ERK phosphorylation, a downstream signal of K-Ras(G12D). Our results suggest that KS-58 NPs represent a novel therapeutic agent for treating colorectal and pancreatic cancers.

  28. Sonication - and γ-ray-mediated biomolecule-liquid metal nanoparticlization in cancer optotheranostics Peer-reviewed

    Qi Yun, Atsushi Kimura, Mitsumasa Taguchi, Eijiro Miyako

    Applied Materials Today　26　101302-101302　2022/03

    Publisher: Elsevier BV

    DOI： 10.1016/j.apmt.2021.101302 　

    ISSN： 2352-9407

  29. Nanoengineered Bifidobacterium bifidum with Optical Activity for Photothermal Cancer Immunotheranostics Peer-reviewed

    Sheethal Reghu, Eijiro Miyako

    Nano Letters　22　1880-1888　2022/02/18

    Publisher: American Chemical Society (ACS)

    DOI： 10.1021/acs.nanolett.1c04037 　

    ISSN： 1530-6984

    eISSN： 1530-6992

  30. Avengers against cancer: A new era of nano-biomaterial-based therapeutics Peer-reviewed

    Nishant Kumar, Sajid Fazal, Eijiro Miyako, Kazuaki Matsumura, Robin Rajan

    Materials Today　51　317-349　2021/12

    DOI： 10.1016/j.mattod.2021.09.020 　

    ISSN： 1369-7021

    eISSN： 1873-4103

  31. Convergence of liquid metal biotechnologies for our health Invited Peer-reviewed

    Eijiro Miyako

    Accounts of Materials Research　2　(10)　858-862　2021/09

  32. Gallium-Based Liquid Metal Particles for Therapeutics International-journal Peer-reviewed

    Wanjie Xie, Francois-Marie Allioux, Jian Zhen Ou, Eijiro Miyako, Shi-Yang Tang, Kourosh Kalantar-Zadeh

    Trends in Biotechnology　39　624-640　2021/06

    Publisher: Elsevier BV

    DOI： 10.1016/j.tibtech.2020.10.005 　

    ISSN： 0167-7799

  33. Optically activatable photosynthetic bacteria-based highly tumor specific immunotheranostics International-journal Peer-reviewed

    Xi Yang, Satoru Komatsu, Sheethal Reghu, Eijiro Miyako

    Nano Today　37　101100　2021/04

  34. Carbon nanohorn coating by electrodeposition accelerate bone formation on titanium implant International-journal Peer-reviewed

    Sari Takada, Eri Hirata, Masatoshi Sakairi, Eijiro Miyako, Yuta Takano, Natsumi Ushijima, Masako Yudasaka, Sumio Iijima, Atsuro Yokoyama

    Artificial Cells, Nanomedicine, and Biotechnology　49　(1)　20-29　2021/01

    DOI： 10.1080/21691401.2020.1865388 　

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    Direct contact between bone and implant materials is required for dental implants. Titanium is used for the implant material owing to its mechanical and biological properties. The anodisation as the surface treatment was employed to enhance osteogenesis around titanium. Moreover, carbon nanohorn (CNH), a type of nanometer-sized carbon material, was reported to promote the bone formation. Thus, it is expected that if the surface of anodised Ti (AnTi) is modified with CNHs, Ti-bone contact would be enhanced. In this study, the Ti surface was modified with CNHs by electrophoresis and obtained anodised titanium coated with CNHs (CNH/AnTi). In vitro, CNH/AnTi attracted osteoblastic cells more than AnTi, thereby the proliferation of osteoblastic cell was enhanced by CNH/AnTi more than by AnTi. In vivo, at 7 and 28 days after implantation of CNH/AnTi or AnTi into the rat femur, more aggressive bone formation was observed on the surface of CNH/AnTi than on AnTi. More importantly, the area where newly formed bone tissue directly attached to CNH/AnTi was significantly larger than that for AnTi, suggesting that "contact osteogenesis" was accelerated on CNH/AnTi during the early post-implantation period. CNH/AnTi would be advantageous especially for the early stages of bone regeneration after surgery.

  35. Photothermogenetic inhibition of cancer stemness by near-infrared-light-activatable nanocomplexes Peer-reviewed

    Yue Yu, Xi Yang, Sheethal Reghu, Sunil C. Kaul, Renu Wadhwa, Eijiro Miyako

    Nature Communications　11　(1)　4117　2020/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41467-020-17768-3 　

    eISSN： 2041-1723

  36. Novel Caffeic Acid Phenethyl Ester-Mortalin Antibody Nanoparticles Offer Enhanced Selective Cytotoxicity to Cancer Cells International-coauthorship Peer-reviewed

    Jia Wang, Priyanshu Bhargava, Yue Yu, Anissa Nofita Sari, Huayue Zhang, Noriyuki Ishii, Kangmin Yan, Zhenya Zhang, Yoshiyuki Ishida, Keiji Terao, Sunil C. Kaul, Eijiro Miyako, Renu Wadhwa

    Cancers　12　(9)　2370-2370　2020/08/21

    Publisher: MDPI AG

    DOI： 10.3390/cancers12092370 　

    eISSN： 2072-6694

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    Caffeic acid phenethyl ester (CAPE) is a key bioactive ingredient of honeybee propolis and is claimed to have anticancer activity. Since mortalin, a hsp70 chaperone, is enriched in a cancerous cell surface, we recruited a unique cell internalizing anti-mortalin antibody (MotAb) to generate mortalin-targeting CAPE nanoparticles (CAPE-MotAb). Biophysical and biomolecular analyses revealed enhanced anticancer activity of CAPE-MotAb both in in vitro and in vivo assays. We demonstrate that CAPE-MotAb cause a stronger dose-dependent growth arrest/apoptosis of cancer cells through the downregulation of Cyclin D1-CDK4, phospho-Rb, PARP-1, and anti-apoptotic protein Bcl2. Concomitantly, a significant increase in the expression of p53, p21WAF1, and caspase cleavage was obtained only in CAPE-MotAb treated cells. We also demonstrate that CAPE-MotAb caused a remarkably enhanced downregulation of proteins critically involved in cell migration. In vivo tumor growth assays for subcutaneous xenografts in nude mice also revealed a significantly enhanced suppression of tumor growth in the treated group suggesting that these novel CAPE-MotAb nanoparticles may serve as a potent anticancer nanomedicine.

  37. Design and Control of Bioinspired Millibots Peer-reviewed

    Sheethal Reghu, Hui You, Kalaivani Seenivasan, Shun Nishimura, Toshiaki Taniike, Eijiro Miyako

    Advanced Intelligent Systems　2　(7)　2000059-2000059　2020/07

    Publisher: Wiley

    DOI： 10.1002/aisy.202000059 　

    ISSN： 2640-4567

    eISSN： 2640-4567

  38. Soap Bubble Pollination Peer-reviewed

    Xi Yang, Eijiro Miyako

    iScience　23　(6)　101188-101188　2020/06

    Publisher: Elsevier BV

    DOI： 10.1016/j.isci.2020.101188 　

    ISSN： 2589-0042

  39. Rational Chemical Multifunctionalization of Graphene Interface Enhances Targeted Cancer Therapy Peer-reviewed

    Matteo Andrea Lucherelli, Yue Yu, Giacomo Reina, Gonzalo Abellán, Eijiro Miyako, Alberto Bianco

    Angewandte Chemie International Edition　59　14034-14039　2020/05/18

    Publisher: Wiley

    DOI： 10.1002/anie.201916112 　

    ISSN： 1433-7851

    eISSN： 1521-3773

  40. Degradation of the sporopollenin exine capsules (SECs) in human plasma Peer-reviewed

    Teng-Fei Fan, Youngkyu Hwang, Michael G. Potroz, Kai-Lin Lau, Ee-Lin Tan, Mohammed Shahrudin Ibrahim, Eijiro Miyako, Nam-Joon Cho

    Applied Materials Today　19　100594　2020/02

  41. Direct Interspecies Electron Transfer Mediated by Graphene Oxide-Based Materials International-journal Invited Peer-reviewed

    Kensuke Igarashi, Eijiro Miyako, Souichiro Kato

    Frontiers in microbiology　10　3068　2020/01

    DOI： 10.3389/fmicb.2019.03068 　

    More details Close

    Conductive materials are known to promote direct interspecies electron transfer (DIET) by electrically bridging microbial cells. Previous studies have suggested that supplementation of graphene oxide (GO) based materials, including GO, and reduced GO (rGO), to anaerobic microbial communities, can promote DIET. This promotion mechanism is thought to be involved in electron transfer via rGO or biologically formed rGO. However, concrete evidence that rGO directly promotes DIET is still lacking. Furthermore, the effects of the physicochemical properties of GO-based materials on DIET efficiency have not been elucidated. In the current work, we investigated whether chemically and biologically reduced GO compounds can promote DIET in a defined model coculture system, and also examined the effects of surface properties on DIET-promoting efficiency. Supplementation of GO to a defined DIET coculture composed of an ethanol-oxidizing electron producer Geobacter metallireducens and a methane-producing electron consumer Methanosarcina barkeri promoted methane production from ethanol. X-ray photoelectron spectroscopy revealed that GO was reduced to rGO during cultivation by G. metallireducens activity. The stoichiometry of methane production from ethanol and the isotope labeling experiments clearly showed that biologically reduced GO induced DIET-mediated syntrophic methanogenesis. We also assessed the DIET-promoting efficiency of chemically reduced GO and its derivatives, including hydrophilic amine-functionalized rGO (rGO-NH2) and hydrophobic octadecylamine-functionalized rGO (rGO-ODA). While all tested rGO derivatives induced DIET, the rGO derivatives with higher hydrophilicity showed higher DIET-promoting efficiency. Optical microscope observation revealed that microbial cells, in particular, G. metallireducens, more quickly adhered to more hydrophilic GO-based materials. The superior ability to recruit microbial cells is a critical feature of the higher DIET-promoting efficiency of the hydrophilic materials. This study demonstrates that biologically and chemically reduced GO can promote DIET-mediated syntrophic methanogenesis. Our results also suggested that the surface hydrophilicity (i.e., affinity toward microbial cells) is one of the important determinants of the DIET-promoting efficiencies. These observations will provide useful guidance for the selection of conductive particles for the improvement of methanogenesis in anaerobic digesters.

  42. Anticancer drug delivery to cancer cells using alkyl amine-functionalized nanodiamond supraparticles Invited Peer-reviewed

    Yue Yu, Xi Yang, Ming Liu, Masahiro Nishikawa, Takahiro Tei, Eijiro Miyako

    Nanoscale Advances　1　3406-3412　2019/08

  43. Multifunctional cancer phototherapy using fluorophore-functionalized nanodiamond supraparticles Peer-reviewed

    Yue Yu, Xi Yang, Ming Liu, Masahiro Nishikawa, Takahiro Tei, Eijiro Miyako

    ACS Applied Bio Materials　2　3693-3705　2019/08

  44. Folic acid receptor-mediated targeting enhances the cytotoxicity, efficacy and selectivity of Withania somnifera leaf extract: In vitro and in vivo evidence Peer-reviewed

    Yue Yu, Jia Wang, Sunil Kaul, Renu Wadhwa, Eijiro Miyako

    Frontiers in Oncology　9　602　2019/07

  45. Species-specific biodegradation of sporopollenin-based microcapsules Peer-reviewed

    Teng-Fei Fan, Michael G. Potroz, Ee-Lin Tan, Mohammed Shahrudin Ibrahim, Eijiro Miyako, Nam-Joon Cho

    Scientific Reports　9　9626　2019/07

  46. Amphipathic nanodiamond supraparticles for anticancer drug loading and delivery Peer-reviewed

    Yue Yu, Xi Yang, Ming Liu, Masahiro Nishikawa, Takahiro Tei, Eijiro Miyako

    ACS Applied Materials & Interfaces　11　18978-18987　2019/05

  47. Microfluidic liquid cell chamber for scanning probe microscopy measurement application Peer-reviewed

    Hokyun Chin, Jurriaan J. J. Gillissen, Eijiro Miyako, Nam-Joon Cho

    Review of Scientific Instruments　90　046105　2019/04

  48. Human blood plasma catalyses the degradation of Lycopodium plant sporoderm microcapsules Peer-reviewed

    Teng-Fei Fan, Michael G. Potroz, Ee-Lin Tan, Jae H. Park, Eijiro Miyako, Nam-Joon Cho

    Scientific Reports　9　2944　2019/02

  49. Spatially controlled molecular encapsulation in natural pine pollen microcapsules Peer-reviewed

    Arun Kumar, Prabhakar, Michael G. Potroz, Soohyun Park, Eijiro Miyako, Nam-Joon Cho

    Particle & Particle Systems Characterization　35　1800151　2018/07

    Publisher: Wiley

    DOI： 10.1002/ppsc.201800151 　

  50. Self-assembled nanodiamond supraparticles for anticancer chemotherapy Peer-reviewed

    Yue Yu, Masahiro Nishikawa, Ming Liu, Takahiro Tei, Sunil C. Kaul, Renu Wadhawa, Minfang Zhang, Junko Takahashi, Eijiro Miyako

    Nanoscale　10　(19)　8969-8978　2018/05/21

    Publisher: Royal Society of Chemistry

    DOI： 10.1039/c8nr00641e 　

    ISSN： 2040-3372 2040-3364

  51. Alternating-magnetic-field-mediated wireless manipulations of a liquid metal for therapeutic bioengineering Peer-reviewed

    Yue Yu, Eijiro Miyako

    iScience　3　134-148　2018/05

    Publisher: Elsevier {BV}

    DOI： 10.1016/j.isci.2018.04.012 　

  52. Recent advances in liquid metal manipulation toward soft robotics and biotechnologies Invited Peer-reviewed

    Yue Yu, Eijiro Miyako

    Chemistry - A European Journal　24　9456-9462　2018/04

    Publisher: Wiley

    DOI： 10.1002/chem.201800605 　

  53. Manipulation of Biomolecule-Modified Liquid-Metal Blobs Peer-reviewed

    Yue Yu, Eijiro Miyako

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　56　(44)　13606-13611　2017/10

    DOI： 10.1002/anie.201705996 　

    ISSN： 1433-7851

    eISSN： 1521-3773

  54. Light-driven liquid metal nanotransformers for biomedical theranostics Peer-reviewed

    Svetlana A. Chechetka, Yue Yu, Xu Zhen, Manojit Pramanik, Kanyi Pu, Eijiro Miyako

    NATURE COMMUNICATIONS　8　15432　2017/05

    DOI： 10.1038/ncomms15432 　

    ISSN： 2041-1723

  55. Withaferin-A kills cancer cells with and without telomerase: chemical, computational and experimental evidences Peer-reviewed

    Yue Yu, Shashank P. Katiyar, Durai Sundar, Zeenia Kaul, Eijiro Miyako, Zhenya Zhang, Sunil C. Kaul, Roger R. Reddel, Renu Wadhwa

    CELL DEATH & DISEASE　8　e2755　2017/04

    DOI： 10.1038/cddis.2017.33 　

    ISSN： 2041-4889

  56. Materially Engineered Artificial Pollinators Peer-reviewed

    Svetlana A. Chechetka, Yue Yu, Masayoshi Tange, Eijiro Miyako

    CHEM　2　(2)　224-239　2017/02

    DOI： 10.1016/j.chempr.2017.01.008 　

    ISSN： 2451-9294

  57. Preparation of small-sized graphene oxide sheets and their biological applications Peer-reviewed

    Zhang, Minfang, Okazaki, Toshiya, Iizumi, Yoko, Miyako, Eijiro, Yuge, Ryota, Bandow, Shunji, Iijima, Sumio, Yudasaka, Masako

    Journal of Materials Chemistry B　4　(1)　121-127　2016/11

    DOI： 10.1039/c5tb01800e 　

  58. Photothermal and mechanical stimulation of cells via dualfunctional nanohybrids Peer-reviewed

    Svetlana A. Chechetka, Motomichi Doi, Benoit P. Pichon, Sylvie Begin-Colin, Eijiro Miyako

    NANOTECHNOLOGY　27　(47)　475102　2016/11

    DOI： 10.1088/0957-4484/27/47/475102 　

    ISSN： 0957-4484

    eISSN： 1361-6528

  59. Optical Regulation of Carbon Nanodots by Chemical Functionalization Peer-reviewed

    Svetlana A. Chechetka, Eijiro Miyako

    CHEMISTRY LETTERS　45　(8)　854-856　2016/08

    DOI： 10.1246/cl.160429 　

    ISSN： 0366-7022

    eISSN： 1348-0715

  60. Semiconducting Polymer Nanobioconjugates for Targeted Photothermal Activation of Neurons Peer-reviewed

    Yan Lyu, Chen Xie, Svetlana A. Chechetka, Eijiro Miyako, Kanyi Pu

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　138　(29)　9049-9052　2016/07

    DOI： 10.1021/jacs.6b05192 　

    ISSN： 0002-7863

  61. Carbon nanohorns allow acceleration of osteoblast differentiation via macrophage activation Peer-reviewed

    Eri Hirata, Eijiro Miyako, Nobutaka Hanagata, Natsumi Ushijima, Norihito Sakaguchi, Julie Russier, Masako Yudasaka, Sumio Iijima, Alberto Bianco, Atsuro Yokoyama

    NANOSCALE　8　(30)　14514-14522　2016/06

    DOI： 10.1039/c6nr02756c 　

    ISSN： 2040-3364

    eISSN： 2040-3372

  62. Magnetically and Near-Infrared Light-Powered Supramolecular Nanotransporters for the Remote Control of Enzymatic Reactions Peer-reviewed

    Svetlana A. Chechetka, Eiji Yuba, Kenji Kono, Masako Yudasaka, Alberto Bianco, Eijiro Miyako

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　55　(22)　6476-6481　2016/05

    DOI： 10.1002/anie.201602453 　

    ISSN： 1433-7851

    eISSN： 1521-3773

  63. Bioinspired Polyaniline-Functional Natural Hairs for Pollen Protection Peer-reviewed

    Svetlana A. Chechetka, Eijiro Miyako

    CHEMISTRYSELECT　1　(5)　1061-1065　2016/04

    DOI： 10.1002/slct.201600320 　

    ISSN： 2365-6549

  64. Lipid Nanotube Tailored Fabrication of Uniquely Shaped Polydopamine Nanofibers as Photothermal Converters Peer-reviewed

    Wuxiao Ding, Svetlana A. Chechetka, Mitsutoshi Masuda, Toshimi Shimizu, Masaru Aoyagi, Hiroyuki Minamikawa, Eijiro Miyako

    Chemistry - A European Journal　22　(13)　4345-4350　2016/03/18

    DOI： 10.1002/chem.201504958 　

    ISSN： 1521-3765 0947-6539

    eISSN： 1521-3765

  65. Light-Active Carbon Nanodots from Autoclaved Bioresources Peer-reviewed

    Svetlana A. Chechetka, Eijiro Miyako

    CHEMISTRYSELECT　1　(3)　608-611　2016/03

    DOI： 10.1002/slct.201600169 　

    ISSN： 2365-6549

  66. Physicochemically functionalized carbon nanohorns for multi-dimensional cancer elimination Invited Peer-reviewed

    Svetlana A. Chechetka, Minfang Zhang, Masako Yudasaka, Eijiro Miyako

    CARBON　97　45-53　2016/02

    DOI： 10.1016/j.carbon.2015.05.077 　

    ISSN： 0008-6223

    eISSN： 1873-3891

  67. Design, synthesis, characterization and properties of magnetic nanoparticle-nanocarbon hybrids Peer-reviewed

    Eijiro Miyako, Benoit P. Pichon, Cecilia Menard-Moyon, Isabella Anna Vacchi, Christophe Lefevre, Sylvie Begin-Colin, Alberto Bianco

    CARBON　96　49-56　2016/01

    DOI： 10.1016/j.carbon.2015.09.045 　

    ISSN： 0008-6223

    eISSN： 1873-3891

  68. In Vivo Remote Control of Reactions in Caenorhabditis elegans by Using Supramolecular Nanohybrids of Carbon Nanotubes and Liposomes Peer-reviewed

    Eijiro Miyako, Svetlana A. Chechetka, Motomichi Doi, Eiji Yuba, Kenji Kono

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　54　(34)　9903-9906　2015/08

    DOI： 10.1002/anie.201504987 　

    ISSN： 1433-7851

    eISSN： 1521-3773

  69. Multifunctional Carbon Nanohorn Complexes for Cancer Treatment Peer-reviewed

    Svetlana A. Chechetka, Benoit Pichon, Minfang Zhang, Masako Yudasaka, Sylvie Begin-Colin, Alberto Bianco, Eijiro Miyako

    CHEMISTRY-AN ASIAN JOURNAL　10　(1)　160-165　2015/01

    DOI： 10.1002/asia.201403059 　

    ISSN： 1861-4728

    eISSN： 1861-471X

  70. Photofunctional Nanomodulators for Bioexcitation Peer-reviewed

    Eijiro Miyako, Julie Russier, Matteo Mauro, Cristina Cebrian, Hiromu Yawo, Cecilia Menard-Moyon, James A. Hutchison, Masako Yudasaka, Sumio Iijima, Luisa De Cola, Alberto Bianco

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　53　(48)　13121-13125　2014/11

    DOI： 10.1002/anie.201407169 　

    ISSN： 1433-7851

    eISSN： 1521-3773

  71. Lysosomal membrane permeabilization: Carbon nanohorn-induced reactive oxygen species generation and toxicity by this neglected mechanism Peer-reviewed

    Mei Yang, Minfang Zhang, Yoshio Tahara, Svetlana Chechetka, Eijiro Miyako, Sumio Iijima, Masako Yudasaka

    TOXICOLOGY AND APPLIED PHARMACOLOGY　280　(1)　117-126　2014/10

    DOI： 10.1016/j.taap.2014.07.022 　

    ISSN： 0041-008X

    eISSN： 1096-0333

  72. Self-Assembled Carbon Nanotube Honeycomb Networks Using a Butterfly Wing Template as a Multifunctional Nanobiohybrid Peer-reviewed

    Eijiro Miyako, Takushi Sugino, Toshiya Okazaki, Alberto Bianco, Masako Yudasaka, Sumio Iijima

    ACS NANO　7　(10)　8736-8742　2013/10

    DOI： 10.1021/nn403083v 　

    ISSN： 1936-0851

    eISSN： 1936-086X

  73. Evaluation of the biological influence of a stable carbon nanohorn dispersion Peer-reviewed

    Masanori Horie, Lilian Kaede Komaba, Hiroko Fukui, Haruhisa Kato, Shigehisa Endoh, Ayako Nakamura, Arisa Miyauchi, Junko Maru, Eijiro Miyako, Katsuhide Fujita, Yoshihisa Hagihara, Yasukazu Yoshida, Hitoshi Iwahashi

    CARBON　54　155-167　2013/04

    DOI： 10.1016/j.carbon.2012.11.015 　

    ISSN： 0008-6223

  74. Carbon nanotube-liposome supramolecular nanotrains for intelligent molecular-transport systems Peer-reviewed

    Eijiro Miyako, Kenji Kono, Eiji Yuba, Chie Hosokawa, Hidenori Nagai, Yoshihisa Hagihara

    NATURE COMMUNICATIONS　3　1226　2012/11

    DOI： 10.1038/ncomms2233 　

    ISSN： 2041-1723

    eISSN： 2041-1723

  75. Photothermic regulation of gene expression triggered by laser-induced carbon nanohorns Peer-reviewed

    Eijiro Miyako, Tomonori Deguchi, Yoshihiro Nakajima, Masako Yudasaka, Yoshihisa Hagihara, Masanori Horie, Mototada Shichiri, Yuriko Higuchi, Fumiyoshi Yamashita, Mitsuru Hashida, Yasushi Shigeri, Yasukazu Yoshida, Sumio Iijima

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　109　(19)　7523-7528　2012/05

    DOI： 10.1073/pnas.1204391109 　

    ISSN： 0027-8424

  76. A Photo-Thermal-Electrical Converter Based On Carbon Nanotubes for Bioelectronic Applications Peer-reviewed

    Eijiro Miyako, Chie Hosokawa, Masami Kojima, Masako Yudasaka, Ryoji Funahashi, Isao Oishi, Yoshihisa Hagihara, Mototada Shichiri, Mizuki Takashima, Keiko Nishio, Yasukazu Yoshida

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　50　(51)　12266-12270　2011/10

    DOI： 10.1002/anie.201106136 　

    ISSN： 1433-7851

    eISSN： 1521-3773

  77. Laser-triggered carbon nanotube microdevice for remote control of biocatalytic reactions Peer-reviewed

    Eijiro Miyako, Hideya Nagata, Ken Hirano, Takahiro Hirotsu

    LAB ON A CHIP　9　(6)　788-794　2009/12

    DOI： 10.1039/b816201h 　

    ISSN： 1473-0197

  78. Micropatterned Carbon Nanotube-Gel Composite as Photothermal Material Peer-reviewed

    Eijiro Miyako, Hideya Nagata, Ken Hirano, Takahiro Hirotsu

    ADVANCED MATERIALS　21　(27)　2819-+　2009/07

    DOI： 10.1002/adma.200802885 　

    ISSN： 0935-9648

  79. Ionic Liquids on Photoinduced Nanotube Composite Arrays as a Reaction Medium Peer-reviewed

    Eijiro Miyako, Tamitake Itoh, Yoji Nara, Takahiro Hirotsu

    CHEMISTRY-A EUROPEAN JOURNAL　15　(31)　7520-7525　2009/07

    DOI： 10.1002/chem.200901348 　

    ISSN： 0947-6539

    eISSN： 1521-3765

  80. Light-Triggered Thermoelectric Conversion Based on a Carbon Nanotube-Polymer Hybrid Gel Peer-reviewed

    Eijiro Miyako, Hideya Nagata, Ryoji Funahashi, Ken Hirano, Takahiro Hirotsu

    CHEMSUSCHEM　2　(5)　419-422　2009/05

    DOI： 10.1002/cssc.200900066 　

    ISSN： 1864-5631

    eISSN： 1864-564X

  81. Light-Driven Thermoelectric Conversion Based on a Carbon Nanotube-Ionic Liquid Gel Composite Peer-reviewed

    Eijiro Miyako, Hideya Nagata, Ryoji Funahashi, Ken Hirano, Takahiro Hirotsu

    CHEMSUSCHEM　2　(8)　740-742　2009

    DOI： 10.1002/cssc.200900069 　

    ISSN： 1864-5631

    eISSN： 1864-564X

  82. Photodynamic Thermoresponsive Nanocarbon-Polymer Gel Hybrids Peer-reviewed

    Eijiro Miyako, Hideya Nagata, Ken Hirano, Takahiro Hirotsu

    SMALL　4　(10)　1711-1715　2008/10

    DOI： 10.1002/smll.200800601 　

    ISSN： 1613-6810

  83. Photodynamic release of fullerenes from within carbon nanohorn Peer-reviewed

    Eijiro Miyako, Hideya Nagata, Ken Hirano, Yoji Makita, Takahiro Hirotsu

    CHEMICAL PHYSICS LETTERS　456　(4-6)　220-222　2008/05

    DOI： 10.1016/j.cplett.2008.03.044 　

    ISSN： 0009-2614

  84. Carbon nanotube-polymer composite for light-driven microthermal control Peer-reviewed

    Eijiro Miyako, Hideya Nagata, Ken Hirano, Takahiro Hirotsu

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　47　(19)　3610-3613　2008/04

    DOI： 10.1002/anie.200800296 　

    ISSN： 1433-7851

    eISSN： 1521-3773

  85. Photoinduced antiviral carbon nanohorns Peer-reviewed

    Eijiro Miyako, Hideya Nagata, Ken Hirano, Kotaro Sakamoto, Yoji Makita, Ken-ichi Nakayama, Takahiro Hirotsu

    NANOTECHNOLOGY　19　(7)　075106　2008/02

    DOI： 10.1088/0957-4484/19/7/075106 　

    ISSN： 0957-4484

  86. Near-infrared laser-triggered carbon nanohorns for selective elimination of microbes Peer-reviewed

    Eijiro Miyako, Hideya Nagata, Ken Hirano, Yoji Makita, Ken-Ichi Nakayama, Takahiro Hirotsu

    NANOTECHNOLOGY　18　(47)　475103　2007/11

    DOI： 10.1088/0957-4484/18/47/475103 　

    ISSN： 0957-4484

  87. Optical resolution of various amino acids using a supported liquid membrane encapsulating a surfactant-protease complex Peer-reviewed

    E Miyako, T Maruyama, F Kubota, N Kamiya, M Goto

    LANGMUIR　21　(10)　4674-4679　2005/05

    DOI： 10.1021/la046789z 　

    ISSN： 0743-7463

  88. A supported liquid membrane encapsulating a surfactant-lipase complex for the selective separation of organic acids Peer-reviewed

    E Miyako, T Maruyama, N Kamiya, M Goto

    CHEMISTRY-A EUROPEAN JOURNAL　11　(4)　1163-1170　2005/02

    DOI： 10.1002/chem.200400691 　

    ISSN： 0947-6539

  89. Highly enantioselective separation using a supported liquid membrane encapsulating surfactant-enzyme complex Peer-reviewed

    E Miyako, T Maruyama, N Kamiya, M Goto

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　126　(28)　8622-8623　2004/07

    DOI： 10.1021/ja049378d 　

    ISSN： 0002-7863

  90. Selective separation of organic acids through a lipase-facilitated organogel membrane Peer-reviewed

    Eijiro Miyako, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

    Membrane　29　236-243　2004/04

    DOI： 10.1023/A:1023536922749 　

  91. Transport of organic acids through a supported liquid membrane driven by lipase-catalyzed reactions Peer-reviewed

    E Miyako, T Maruyama, N Kamiya, M Goto

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING　96　(4)　370-374　2003/10

    DOI： 10.1263/jbb.96.370 　

    ISSN： 1389-1723

  92. Enzyme-facilitated enantioselective transport of (S)-ibuprofen through a supported liquid membrane based on ionic liquids Peer-reviewed

    E Miyako, T Maruyama, N Kamiya, M Goto

    CHEMICAL COMMUNICATIONS　(23)　2926-2927　2003/10

    DOI： 10.1039/b310990a 　

    ISSN： 1359-7345

  93. Use of ionic liquids in a lipase-facilitated supported liquid membrane Peer-reviewed

    E Miyako, T Maruyama, N Kamiya, M Goto

    BIOTECHNOLOGY LETTERS　25　(10)　805-808　2003/05

    DOI： 10.1023/A:1023536922749 　 10.1023/a:1023536922749 　

    ISSN： 0141-5492

Show all ︎Show first 5

Research Projects 11

  1. Realtime observation and optical control of living microbial probes in blood vessels

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Japan Advanced Institute of Science and Technology

    2023/04/01 - 2028/03/31

  2. 転移性肺癌を標的とする癌光細菌療法の創出

    都 英次郎, 重村 克巳

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 挑戦的研究(開拓)

    Institution: 北陸先端科学技術大学院大学

    2022/06/30 - 2025/03/31

  3. Mechanics of Morphological Compensation, and its Application to Sensing and Control of Soft Robots

    Ho Anhvan, 渋谷 恒司, 高村 禅, 都 英次郎

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 北陸先端科学技術大学院大学

    2021/04/01 - 2024/03/31

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    In the first year, overall, research hypothesis has been intensively proposed and elaborated for finding out suitable showcases for investigating the morphological compensation ability in soft sensing systems: 1) Ho has proposed a morphological compensation strategy for a soft whisker sensor upon being trimmed partly. By suitably changing the inner pressure of the embedded chamber, the sensitivity of relative contact location along the whisker body can be compensated. Also, a genetic algorithm-based optimization has been conducted to find out the suitable structure of the whisker for maximizing compensation ability. In addition, several interactive models on SOFA platforms have been built toward construction of topological change-allowed program, such as simulation of an inflated balloon or barrel-shape soft sensing system. <BR> 2) Shibuya and Ho have investigated design feasibility of several soft tactile sensing systems that can change their morphology, such as wrinkle-based (WR) and magnetorheological (MR) fluid-based soft interfaces. Here, by changing the inner pressure (WR) or magnetic field (MR), the shape and stiffness can be recognized, leading to change in the output of the embedded sensing elements. Such systems are suitable for further investigation of morphological compensation. <BR> 3) Miyako and Ho investigated an initial idea on a novel actuation system using corona-discharge phenomenon, which ignites movement of bio-materials in the air. Takamura and Ho also focused on fabrication of micro-patterned structures that enhances the tribological properties of soft structures.

  4. 動物用がん診断・治療を可能にする機能性光細菌

    都 英次郎

    Offer Organization: 科学技術振興機構

    Category: 産学が連携した研究開発成果の展開/研究成果展開事業/研究成果最適展開支援プログラム(A-STEP)/産学共同(育成型)

    2022 - 2024

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    本研究課題では、機能性光細菌が有する特異な抗がん活性・蛍光放射性と集積・増殖性を利用したマウス体内における有効性を検討し、将来の”動物用がん光診断・治療機器”の開発に繋げることを目的とする。より具体的には、獣医がん診断で頻繁に見られる乳腺がんを標的とした当該細菌の、① 低酸素下の微小環境に高選択的に集積し増殖する作用、② 免疫賦活化作用を利用したがん細胞殺傷効果、③ 光照射による蛍光特性を利用した生体内がんイメージング効果、④ 安全性、を評価する。本研究課題によって、動物体内の高精度な腫瘍検出技術ならびにがん細胞の根絶可能な治療法が実現できれば、その社会的・学術的な意義は大きい。

  5. Investigations and control of functional nanocomplexes in tumor environment

    Miyako Eijiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Japan Advanced Institute of Science and Technology

    2019/04/01 - 2022/03/31

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    Due to their unique characteristics, gallium-based liquid metal (LM) nanoparticles have been applied in various research fields. LM nanoparticle surface-modification design is essential for enhancing the original LM properties and physicochemical multifunctionalization. Besides, standard cancer treatments are currently limited to surgery, radiation, and chemotherapy. Unfortunately, all three methods risk damage to normal tissues or incomplete eradication of the cancer. Development of LM-based nanomedicinal technology is challenging area for exploring new and innovative applications in the advanced cancer treatments. We have created a cancer optotheranostics using functional eutectic gallium-indium (EGaIn)-based LM nanoparticles that were successfully synthesized by various biomolecules (gelatin, DNA, lecithin, and bovine serum albumin), sonication, and quantum beam (γ-ray) radiation (Figure 1).

  6. Nanocomplexes for in vivo control of cellular functions

    Miyako Eijiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: National Institute of Advanced Industrial Science and Technology

    2016/04/01 - 2019/03/31

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    In the last decade, there has been great progress in technologies for the remote control of organisms through physical and chemical manipulation. In particular, methods involving lasers have proven useful for the control of biological functions in living organisms through simple manipulation with laser beams. Ultraviolet, short-wavelength visible, and infrared light are generally used in optical techniques for the control of biological functions in organisms. However, these types of light do not efficiently penetrate biological tissues. It is well known that near-infrared (NIR) rays can penetrate tissues because biological systems are relatively transparent to these wavelengths of light. We have developed NIR-laser-driven nanocomplexes for remote control of cellular functions. I believe that the technologies will help to create a new state-of-the-art tool for the comprehensive analysis of "real" biological molecular information at the single-cell level.

  7. Multidimensional cellular manipulation by functional nanocomplexes(Fostering Joint International Research)

    Miyako Eijiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research)

    2017 - 2019

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    Stimulating cells by light is an attractive technology to investigate cellular function and deliver innovative cell-based therapy. However, current techniques generally use poorly biopermeable light, which prevents broad applicability. Here, we show that a new type of functional nanocomplexes, synthesized from multi-walled carbon nanohorns, polyglycerol-phospholipid, and antibody, enables photothermal control of Ca2+ influx into cells overexpressing transient receptor potential vanilloid type-2 (TRPV2). The nanohybrid is simply operated by application of highly biotransparent near-infrared light. The technology would revolutionize remote control of cellular function.

  8. Materially Engineered Artificial Pollinators

    Miyako Eijiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: National Institute of Advanced Industrial Science and Technology

    2016/04/01 - 2018/03/31

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    The decline in honeybee populations is a global issue with significant repercussions with respect to the pollination of plants. The simultaneous expression of multifunctionality from synthesized ionic liquid gels (ILGs) for biotechnology is presented in this study. We also demonstrate that, when mixed with photochromic organic compounds, ILGs display rapid color changes, similar to light-triggered camouflage, on living flies. By further exploiting the physicochemical properties of ILGs, we were able to achieve effective pollen adsorption by ILG-functionalized ants from Tulipa flowers with high biocompatibility. In addition, a radiowave-controllable bio-inspired flying robot equipped with ILG-coated vertically aligned animal hairs could be used to successfully pollinate Lilium flowers.

  9. Hemostatic material based on functional nanocarbon complexes

    Miyako Eijiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: National Institute of Advanced Industrial Science and Technology

    2015/04/01 - 2016/03/31

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    We describe a carbon nanotube-liposome-based supramolecular nanohybrid capable of permeation through cells with high biocompatibility. The nanohybrid can be loaded with a variety of functional molecules and is structurally controlled by near-infrared laser irradiation for the release of molecules from the nanohybrids in a targeted manner via microscopy. We implemented the controlled release of molecules from nanohybrids and demonstrated their efficacy in remote regulation of photo-induced nanohybrid functions. As a proof of principle, nanohybrids loaded with amiloride were successfully used in spatiotemporal blocking of targeted amiloride-sensitive mechanosensory neurons in living Caenorhabditis elegans. Our prototype could inspire new designs with biomimetic parasitism and symbiosis and biologically active nanorobots for higher-level manipulation of organisms.

  10. Control of celluar functions by chemically functionalized nanocarbons

    Miyako Eijiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (A)

    Institution: National Institute of Advanced Industrial Science and Technology

    2013/04/01 - 2016/03/31

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    A single organism comprises diverse types of cells. To acquire a detailed understanding of the biological functions of each cell, a comprehensive control and analysis of homeostatic processes at the single-cell level are required. In this study, we develop a new type of light-driven nanomodulator comprising dye-functionalized carbon nanohorns (CNHs) that generate heat and reactive oxygen species under biologically transparent near-infrared (NIR) laser irradiation. By exploiting the chemico-physical properties of the nanohorns, cellular calcium ion flux and membrane currents were successfully controlled at the single-cell level. In addition, the nanomodulator allows a remote bioexcitation of tissues during NIR laser exposure making this system a powerful tool for single-cell analyses and innovative cell therapies.

  11. A photo-thermal-electrical converter based on carbon nanotubes for bioelectronic applications

    MIYAKO Eijiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: National Institute of Advanced Industrial Science and Technology

    2011 - 2013

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    There is currently substantial interest in creating bioelectronic devices that can be implanted in and attached to humans for sensing and control of organs and internal systems in order to prolong and improve the quality of life. In the present study , we demonstrate that 1) a well-dispersed single-walled CNT/poly(dimethylsiloxane) (SWNT-PDMS) composite can be formed, and a novel photo-thermal-electrical (PTE) converter fabricated with a CNT polymer composite can effectively convert the photothermal energy of CNTs into electricity; 2) the PTE converter can supply electrical power for stimulation of electrical activity in physiological tissues; and 3) the PTE converter was effective in the body of a rat. These results dramatically extend the concept of a PTE converter into new areas and applications.

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