Details of the Researcher

PHOTO

Toru Tamahara
Section
Tohoku Medical Megabank Organization
Job title
Senior Assistant Professor
Degree

Research History 6

  • 2021/04 - Present
    Tohoku University　Tohoku Medical Megabank Organization　Senior Associate Professor

  • 2019/04 - Present
    Tohoku University, Sendai, Japan　Tohoku Medical Megabank Organization　assistant professor

  • 2017/04 - 2019/03
    Tohoku University, Sendai, Japan　Graduate School of Dentistry　assistant professor

  • 2016/04 - 2017/03
    Tohoku University Hospital, Sendai, Japan　perioperative oral support center　assistant professor

  • 2015/04 - 2016/03
    Tohoku University Hospital, Sendai, Japan　Preventive dentistry　Clinical Fellow

  • 2010/04 - 2011/03
    Tohoku University Hospital, Sendai, Japan　Graduate Medical Education Center　Dental resident

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Education 2

  • Tohoku University, Sendai, Japan　Graduate School of Dentistry

    2011/04 - 2015/03

  • Tohoku University, Sendai, Japan,　faculty of dentistry

    2004/04 - 2010/03

Committee Memberships 2

  • 公益財団法人８０２０推進財団　令和6年度歯科保健活動事業助成

    2024/09 - 2025/03

  • 財団法人 富徳会　平成29年度研究者助成金支給者

    2017/09 - 2018/03

Professional Memberships 2

  • 日本口腔外科学会

  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

Research Interests 8

  • metagenome

  • periodontitis

  • oral care

  • perioperative dentistry

  • Bach2

  • dentistry

  • transcriptional factor

  • oral mucositis

Research Areas 2

  • Life sciences / Molecular biology / biochemistry

  • Life sciences / Community dentistry / perioperatiove dentistry

Papers 33

  1. Establishment and Operation of a New Style Clinical Biobank: The Tohoku University Clinical Biobank.

    Bin Li, Kazuki Kumada, Muneaki Shimada, Hidekazu Shirota, Hideki Tokunaga, Mio Yamaguchi-Tanaka, Chihiro Inoue, Yuto Yamazaki, Akihiro Yamamura, Toru Furukawa, Keigo Komine, Soichi Ogishima, Toru Tamahara, Sakae Saito, Ritsuko Shimizu, Masahiro Iikubo, Kensuke Yamauchi, Tomo Saito, Shin-Ichi Fujimaki, Yuko Abe, Naoki Nakamura, Hideki Ota, Fuji Nagami, Kengo Kinoshita, Toru Nakazawa, Hozumi Motohashi, Naoto Ishii, Chikashi Ishioka, Hideo Harigae, Teiji Tominaga, Nobuo Yaegashi, Masayuki Yamamoto

    The Tohoku journal of experimental medicine　2026/01/15

    DOI： 10.1620/tjem.2025.J152 　

  2. Association of anterior crossbite and open bite with the number of remaining teeth: A cross-sectional study from the Tohoku medical megabank cohort. International-journal

    Kento Numazaki, Toru Tamahara, Takamasa Komiyama, Takako Numazaki, Maki Goto, Ritsuko Shimizu, Itaru Mizoguchi, Kaoru Igarashi, Hiroyasu Kanetaka

    Clinical oral investigations　30　(1)　43-43　2026/01/08

    DOI： 10.1007/s00784-025-06715-5 　

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    OBJECTIVES: Malocclusion, particularly anterior crossbite and open bite, contributes to abnormal occlusal stress distribution, potentially leading to tooth loss. We examined the association between anterior malocclusions and tooth loss-related outcomes in a large-scale, community-based sample of Japanese adults. MATERIALS AND METHODS: This cross-sectional study targeted 17,349 participants aged ≥ 40 years from the Tohoku Medical Megabank Cohort Study (2013-2017). Based on overjet and overbite, participants were classified into normal occlusion (n = 16,790), anterior open bite (n = 177), anterior crossbite (n = 348), and combined malocclusion (n = 34). Outcomes included ≤ 19 remaining natural teeth and posterior tooth loss. Adjusted prevalence ratios (PRs) and 95% confidence intervals (CIs) were calculated using modified Poisson regression models. RESULTS: The crossbite group demonstrated a higher prevalence of ≤ 19 remaining teeth (PR, 1.48; 95% CI, 1.04-2.10) and posterior tooth loss (PR, 1.14; 95% CI, 1.07-1.20) than the normal group; the open bite group exhibited a lower prevalence of posterior tooth loss (PR, 0.79; 95% CI, 0.69-0.90). Heatmap analysis revealed lower molar tooth retention in the crossbite group and higher retention in the open bite group. CONCLUSIONS: Anterior crossbite is associated with increased posterior tooth loss, whereas open bite shows a weaker association. These findings suggest that specific anterior malocclusions may be linked to reduced tooth retention. CLINICAL RELEVANCE: Identification of anterior malocclusion types, particularly anterior crossbite, may help identify individuals at higher risk for tooth loss. Orthodontic management of anterior crossbite might support posterior dentition preservation and long-term oral function.

  3. Metabolic Syndrome Develops Cardia Cancer via Nuclear Factor-E2-related Factor 2-Programmed Death-Ligand 1 Signaling. International-journal

    Keisuke Kusano, Kaname Uno, Toru Tamahara, Naoki Asano, Koichiro Sudo, Mizuki Tanabe, Koya Ogasawara, Takeshi Kanno, Tomoyuki Koike, Ritsuko Shimizu, Atsushi Masamune

    Cellular and molecular gastroenterology and hepatology　20　(1)　101629-101629　2026

    DOI： 10.1016/j.jcmgh.2025.101629 　

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    BACKGROUND & AIMS: The incidence of gastric cardia adenocarcinoma (GCA) and metabolic syndrome (MetS) have increased concurrently. Lipopolysaccharide (LPS) may be a biomarker for GCA development and treatment resistance of immune checkpoint inhibitors. We aimed to elucidate whether high-fat diet (HFD)-related endotoxemia progresses GCA via programmed death-ligand 1 (PD-L1) signaling. METHODS: We studied K19-Wnt1/C2mE mice fed HFD or control diet with or without systemic administration of Escherichia coli LPS ± clodronate liposomes (CLs). To clarify the role of nuclear factor E2-related factor 2 (Nrf2) in tumorigenesis, we generated Nrf2-deficient K19-Wnt1/C2mE mice. We performed further experiments using MKN7 and THP-1 cells. RESULTS: In the HFD + LPS group of K19-Wnt1/C2mE mice, tumor growth with increase in tumor cell proliferation and macrophage infiltration was observed with gut dysbiosis, gut mucosal barrier damage, endotoxemia, and insulin resistance. The expression of 8-OHdG, NAD(P)H quinone oxidoreductase 1 (Nqo1), Tumor necrosis factor (TNF)-a, phosphorylated nuclear factor-kappa B (p-NFκB), and PD-L1 was upregulated in tumors. TNF-α expression was observed in tumor cells and stromal macrophages. These effects were abolished in the HFD + LPS + CL group. In the Nrf2-deficient K19-Wnt1/C2mE mice, tumors shrank as TNF-α and PD-L1 expression decreased, without improvement of gut barrier damage and endotoxemia. LPS stimulation of phorbol 12-myristate 13-acetate-treated THP-1 cells induced the expression of TNF-α, which activated NFκB-PD-L1 signaling in cocultured MKN7 cells. LPS stimulation of MKN7 cells increased the expression of NQO1, phosphorylated NFκB, and PD-L1, and NRF2 directly regulated CD274 transcription. CONCLUSIONS: HFD-related metabolic endotoxemia may promote GCA progression via PD-L1 induction in tumor cells directly through Nrf2 signaling activated by LPS and through NFκB signaling by TNF-α from LPS-activated macrophages in tumor microenvironment.

  4. Ecological and Functional Landscape of the Oral Microbiome: A Multi-Site Analysis of Saliva, Dental Plaque and Tongue Coating International-journal

    Toru Tamahara, Atsumu Kouketsu, Satoshi Fukase, Pawat Sripodok, Tatsuru Saito, Akiko Ito, Bin Li, Kazuki Kumada, Muneaki Shimada, Masahiro Iikubo, Ritsuko Shimizu, Kensuke Yamauchi, Tsuyoshi Sugiura

    Microorganisms　14　(1)　2025/12/19

    DOI： 10.3390/microorganisms14010002 　

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    The oral cavity contains several microbial niches, including saliva, dental plaque and tongue coating, each shaped by distinct local environments and host factors. This study compared the ecological and functional characteristics of the microbiomes of these three oral sites within the same individuals and examined host conditions associated with their variation. Saliva, supragingival plaque and tongue coating samples were collected simultaneously from 31 adults without clinical oral lesions. The bacterial 16S rRNA gene (V3-V4 region) was sequenced using the Illumina MiSeq platform, and analyses included α and β diversity, Mantel correlations, differential abundance tests, network analysis and functional prediction. The three sites displayed a clear ecological gradient. Saliva and tongue coating were taxonomically similar but were influenced by different host factors, whereas plaque maintained a distinct, biofilm-like structure with limited systemic influence. Functional divergence was most pronounced on the tongue coating despite its taxonomic similarity to saliva, whereas functional differences between saliva and plaque were modest despite larger taxonomic separation. These findings indicate that microbial composition and function vary independently across oral niches and support the need for multi-site sampling to more accurately characterize oral microbial ecology.

  5. Direct radiation damage to human tooth under IMRT for head and neck cancer: physicochemical evidence supporting a non-salivary mechanism for radiation-related caries International-journal

    Toru Tamahara, Atsumu Kouketsu

    Radiation and Environmental Biophysics　2025/12/15

    DOI： 10.1007/s00411-025-01180-w 　

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    Radiation-related dental caries (RRC) is a rapidly progressing and treatment-resistant condition commonly observed after head and neck radiotherapy. It has traditionally been attributed to radiation-induced salivary gland dysfunction; however, RRC often develops even when appropriate oral care is provided, including fluoride application and regular hygiene practices. This clinical inconsistency suggests that salivary dysfunction alone cannot fully explain the onset and severity of RRC. The direct physicochemical effects of radiation on the organic and inorganic components of dental hard tissues remain poorly understood. In this study, extracted human third molars were subjected to a clinical IMRT protocol, using either a single high dose (20 Gy × 1) or a fractionated regimen (2 Gy/day × 35, total 70 Gy). We then evaluated radiation-induced changes in tooth structure by measuring Vickers microhardness, acid resistance (calcium elution), collagen degradation (autofluorescence), and internal dentin pH. Radiation exposure significantly altered enamel hardness: it increased after 20 Gy but decreased following 70 Gy. Calcium release increased in crown enamel (70 Gy) and root dentin (20 Gy), while decreasing in crown dentin (20 Gy). Autofluorescence imaging showed a significant reduction in dentinal collagen after fractionated exposure. Both groups exhibited an alkaline shift in dentin pH, more pronounced in the single-dose group. These findings provide physicochemical evidence for a non-salivary mechanism contributing to RRC. To effectively prevent RRC, additional strategies to reduce direct radiation damage to dental tissues may be necessary alongside conventional salivary-focused approaches.

  6. Differences in the Oral Microbiome Between Patients With and Without Oral Squamous Cell Carcinoma. International-journal

    Satoshi Fukase, Atsumu Kouketsu, Toru Tamahara, Tatsuru Saito, Akiko Ito, Yutaro Higashi, Tomonari Kajita, Tsuyoshi Kurobane, Masaaki Miyakoshi, Masahiro Iikubo, Ritsuko Shimizu, Tetsu Takahashi, Kensuke Yamauchi, Tsuyoshi Sugiura

    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology　2025/12/05

    DOI： 10.1111/jop.70099 　

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    BACKGROUND: Although studies have demonstrated a relationship between pathogenic microorganisms and oral cancer, no study has demonstrated a relationship between changes in bacterial flora and oral squamous cell carcinoma (OSCC). Therefore, we investigated the association between oral microbiota and oral squamous cell carcinoma using metagenomic analysis. METHODS: Saliva samples from 64 patients with OSCC and 50 healthy controls who visited the Department of Oral Surgery, Tohoku University Hospital, were collected, and bacterial genomic DNA was extracted using polymerase chain reaction amplification. Single-end sequencing was performed using the Illumina MiSeq platform, and sequence data were analyzed using the Quantitative Insights Into Microbial Ecology 2 platform. The Steel-Dwass test was used for between-group comparisons, and Analysis of Compositions of Microbiomes with Bias Correction was used to detect significant differences in microbiome composition. RESULTS: Significant differences were observed in alpha-diversity indices of bacterial flora (richness, Faith- phylogenetic diversity, Shannon index) in the OSCC group compared to those in the control group. Among the OSCC group, patients with larger tumor diameters and lymph node metastases (T3/T4, N1 or greater) formed independent clusters in the beta diversity analysis of the bacterial flora. Bacteria of the Actinomycetia phylum, such as Actinomyces and Rothia, were significantly reduced in patients with higher stage and pathological grade. Conversely, bacteria of the phylum Spirochaetia and Proteobacteria, particularly those of the genus Treponema, were significantly elevated in advanced cancer cases. CONCLUSIONS: Our results suggest that changes in the oral microbiota may play a role in OSCC development and progression.

  7. Bacterial Involvement in Oral Squamous Cell Carcinoma and Potentially Malignant Oral Disorders International-journal

    Atsumu Koketsu, Satoshi Fukase, Toru Tamahara, Tatsuru Saito, Akiko Ito, Yutaro Higashi, Tomonari Kajita, Tsuyoshi Kurobane, Masaaki Miyakoshi, Masahiro Iikubo, Kazuki Kumada, Bin Li, Muneaki Shimada, Ritsuko Shimizu, Tetsu Takahashi, Kensuke Yamauchi, Tsuyoshi Sugiura

    Oral Diseases　2025/10/09

    DOI： 10.1111/odi.70115 　

  8. 反対咬合・開咬と歯の喪失との関連 東北メディカル・メガバンク機構のデータを用いた横断研究

    沼崎 研人, 玉原 亨, 沼崎 貴子, 後藤 まき, 五十嵐 薫, 金高 弘恭

    日本矯正歯科学会大会プログラム・抄録集　84回　167-167　2025/09

    Publisher: (公社)日本矯正歯科学会

  9. Effect of Japanese traditional medication on males with diarrhea-predominant irritable bowel syndrome and gut microbiome: A single-arm prospective study

    Ryutaro Arita, Shin Takayama, Toru Tamahara, Yuichi Aoki, Soichiro Kaneko, Akiko Kikuchi, Junko Kawashima, Yoshiyuki Kasahara, Kota Ishizawa, Ritsuko Shimizu, Tadashi Ishii

    European Journal of Integrative Medicine　2025/09

    DOI： 10.1016/j.eujim.2025.102512 　

  10. Cohort Profile Update: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) 2023 update. International-journal

    Taku Obara, Mami Ishikuro, Aoi Noda, Keiko Murakami, Masatsugu Orui, Genki Shinoda, Fumihiko Ueno, Fumiko Matsuzaki, Tomomi Onuma, Hiroko Matsubara, Hirohito Metoki, Masahiro Kikuya, Rieko Hatanaka, Ippei Chiba, Kumi Nakaya, Mana Kogure, Naoki Nakaya, Junichi Sugawara, Shigeo Kure, Mika Kobayashi, Tomoko Kobayashi, Yoichi Suzuki, Hiroshi Kawame, Mika Sakurai-Yageta, Sachiko Nagase, Naoki Nakamura, Tomohiro Nakamura, Satoshi Mizuno, Satoshi Nagaie, Soichi Ogishima, Akira Narita, Gen Tamiya, Sachie Koreeda, Fuji Nagami, Toru Tamahara, Maki Goto, Akihito Otsuki, Makiko Taira, Takanori Hidaka, Junko Kawashima, Eiichi N Kodama, Akira Uruno, Yohei Hamanaka, Hiroaki Tomita, Hiroaki Hashizume, Kenichi Noguchi, Fumiki Katsuoka, Seizo Koshiba, Kazuki Kumada, Takahiro Nobukuni, Kinuko Ohneda, Shunji Mugikura, Ritsuko Shimizu, Masataka Kambe, Yoshinobu Saito, Tadao Kobayashi, Yoko Izumi, Kengo Kinoshita, Nobuo Fuse, Nobuo Yaegashi, Atsushi Hozawa, Masayuki Yamamoto, Shinichi Kuriyama

    International journal of epidemiology　54　(5)　2025/08/18

    DOI： 10.1093/ije/dyaf148 　

  11. Co-stimulation with high-fat diet and acidic bile salts may promote Warburg effect in gastric carcinogenesis around the squamo-columnar junction in Gan mice International-journal

    Koichiro Sudo, Kaname Uno, Toru Tamahara, Naoki Asano, Keisuke Kusano, Mizuki Tanabe, Kouya Ogasawara, Takeshi Kanno, Tomoyuki Koike, Ritsuko Shimizu, Atsushi Masamune

    American Journal of Physiology-Gastrointestinal and Liver Physiology　328　(6)　G645-G662　2025/04/17

    DOI： 10.1152/ajpgi.00305.2024 　

    ISSN： 0193-1857

    eISSN： 1522-1547

  12. 消化管疾患の病態理解を深める研究 経口抗生剤投与が腸管バリア傷害を増悪し食道胃接合部腺癌を進展させる

    小笠原 光矢, 須藤 洸一郎, 宇野 要, 玉原 亨, 浅野 直喜, 正宗 淳

    日本消化器病学会雑誌　122　(臨増総会)　A194-A194　2025/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  13. Hangeshashinto Increases the Resistance of Cells Against Cisplatin Cytotoxicity by Regulating the Cell Cycle

    Toru Tamahara, Ryutaro Arita

    Natural Product Communications　2025/03

    DOI： 10.1177/1934578X251324404 　

  14. Sequential Sampling of the Gastrointestinal Tract to Characterize the Entire Digestive Microbiome in Japanese Subjects International-journal

    Kota Ishizawa, Toru Tamahara, Suguo Suzuki, Yutaka Hatayama, Bin Li, Michiaki Abe, Yuichi Aoki, Ryutaro Arita, Natsumi Saito, Minoru Ohsawa, Soichiro Kaneko, Rie Ono, Shin Takayama, Muneaki Shimada, Kazuki Kumada, Tomoyuki Koike, Atsushi Masamune, Ko Onodera, Tadashi Ishii, Ritsuko Shimizu, Takeshi Kanno

    Microorganisms　12　(7)　1324-1324　2024/06/28

    Publisher: MDPI AG

    DOI： 10.3390/microorganisms12071324 　

    eISSN： 2076-2607

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    The gastrointestinal (GI) tract harbors trillions of microorganisms known to influence human health and disease, and next-generation sequencing (NGS) now enables the in-depth analysis of their diversity and functions. Although a significant amount of research has been conducted on the GI microbiome, comprehensive metagenomic datasets covering the entire tract are scarce due to cost and technical challenges. Despite the widespread use of fecal samples, integrated datasets encompassing the entire digestive process, beginning at the mouth and ending with feces, are lacking. With this study, we aimed to fill this gap by analyzing the complete metagenome of the GI tract, providing insights into the dynamics of the microbiota and potential therapeutic avenues. In this study, we delved into the complex world of the GI microbiota, which we examined in five healthy Japanese subjects. While samples from the whole GI flora and fecal samples provided sufficient bacteria, samples obtained from the stomach and duodenum posed a challenge. Using a principal coordinate analysis (PCoA), clear clustering patterns were identified; these revealed significant diversity in the duodenum. Although this study was limited by its small sample size, the flora in the overall GI tract showed unwavering consistency, while the duodenum exhibited unprecedented phylogenetic diversity. A visual heat map illustrates the discrepancy in abundance, with Fusobacteria and Bacilli dominating the upper GI tract and Clostridia and Bacteroidia dominating the fecal samples. Negativicutes and Actinobacteria were found throughout the digestive tract. This study demonstrates that it is possible to continuously collect microbiome samples throughout the human digestive tract. These findings not only shed light on the complexity of GI microbiota but also provide a basis for future research.

  15. Accelerated plasma-cell differentiation in Bach2-deficient mouse B cells is caused by altered IRF4 functions. International-journal

    Kyoko Ochiai, Hiroki Shima, Toru Tamahara, Nao Sugie, Ryo Funayama, Keiko Nakayama, Tomohiro Kurosaki, Kazuhiko Igarashi

    The EMBO journal　43　(10)　1947-1964　2024/04/11

    DOI： 10.1038/s44318-024-00077-6 　

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    Transcription factors BACH2 and IRF4 are both essential for antibody class-switch recombination (CSR) in activated B lymphocytes, while they oppositely regulate the differentiation of plasma cells (PCs). Here, we investigated how BACH2 and IRF4 interact during CSR and plasma-cell differentiation. We found that BACH2 organizes heterochromatin formation of target gene loci in mouse splenic B cells, including targets of IRF4 activation such as Aicda, an inducer of CSR, and Prdm1, a master plasma-cell regulator. Release of these gene loci from heterochromatin in response to B-cell receptor stimulation was coupled to AKT-mTOR pathway activation. In Bach2-deficient B cells, PC genes' activation depended on IRF4 protein accumulation, without an increase in Irf4 mRNA. Mechanistically, a PU.1-IRF4 heterodimer in activated B cells promoted BACH2 function by inducing gene expression of Bach2 and Pten, a negative regulator of AKT signaling. Elevated AKT activity in Bach2-deficient B cells resulted in IRF4 protein accumulation. Thus, BACH2 and IRF4 mutually modulate the activity of each other, and BACH2 inhibits PC differentiation by both the repression of PC genes and the restriction of IRF4 protein accumulation.

  16. Intracanal microbiome profiles of two apical periodontitis cases in one patient: A comparison with saliva and plaque profiles. International-journal

    Keiko Yamaki, Toru Tamahara, Jumpei Washio, Takuichi Sato, Ritsuko Shimizu, Satoru Yamada

    Clinical and experimental dental research　10　(2)　e862　2024/04

    DOI： 10.1002/cre2.862 　

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    OBJECTIVES: To determine the characteristics of the endodontic microbiome. MATERIAL AND METHODS: Saliva, plaque, and infected root canal wall dentin of two teeth suffering from apical periodontitis were harvested from a 58-year-old man. Bacterial DNA was extracted from each sample, and 16S rRNA gene analysis targeting the V3-V4 region was conducted on the Illumina MiSeq platform using QIIME2. The functional potential of the microbiomes was inferred using PICRUSt2. RESULTS: The four microbiomes were different in structure and membership, yet the nine most abundant metabolic pathways were common among them. The two endodontic microbiomes were more anaerobic, rich in Firmicutes, and scarce in Actinobacteriota and Proteobacteria, compared with saliva and plaque microbiomes. Their profiles were dissimilar despite their clinical and radiographic similarities. CONCLUSIONS: The endodontic microbiomes were anaerobic, rich in Firmicutes, scarce in Actinobacteriota and Proteobacteria, and considerably varied within an individual.

  17. The Significance of Bile in the Biliopancreatic Limb on Metabolic Improvement After Duodenal-Jejunal Bypass. International-journal

    Tomomi Kawana, Hirofumi Imoto, Naoki Tanaka, Takahiro Tsuchiya, Akihiro Yamamura, Fumito Saijo, Masamitsu Maekawa, Toru Tamahara, Ritsuko Shimizu, Kei Nakagawa, Shinobu Ohnuma, Takashi Kamei, Michiaki Unno

    Obesity surgery　34　(5)　1665-1673　2024/03/21

    DOI： 10.1007/s11695-024-07176-7 　

  18. Progress report of the Tohoku Medical Megabank Community-Based Cohort Study: Study profile of the repeated center-based survey during second period in Miyagi Prefecture.

    Atsushi Hozawa, Kumi Nakaya, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Junichi Sugawara, Eiichi Kodama, Yohei Hamanaka, Tomoko Kobayashi, Akira Uruno, Naho Tsuchiya, Takumi Hirata, Akira Narita, Akito Tsuboi, Toru Tamahara, Akihito Otsuki, Maki Goto, Makiko Taira, Ritsuko Shimizu, Kichiya Suzuki, Taku Obara, Masahiro Kikuya, Hirohito Metoki, Mami Ishikuro, Inaho Danjoh, Soichi Ogishima, Satoshi Nagaie, Naoko Minegishi, Masahiro Hiratsuka, Kazuki Kumada, Ichiko Nishijima, Takahiro Nobukuni, Yumi Yamaguchi-Kabata, Fuji Nagami, Shigeo Kure, Nobuo Fuse, Kengo Kinoshita, Yoko Izumi, Shinichi Kuriyama, Masayuki Yamamoto

    Journal of epidemiology　34　(9)　434-443　2024/02/24

    DOI： 10.2188/jea.JE20230241 　

  19. A HIGH-FAT DIET MAY DEVELOP BILE-INDUCED CARCINOGENESIS AT ESOPHAGOGASTRIC JUNCTION THROUGH SYSTEMIC INFLAMMATION AGAINST TRANSUDATES FROM DYSBIOTIC GUT.

    Toru Tamahara

    GASTROENTEROLOGY　2024

  20. A HIGH-FAT DIET MAY INDUCE THE PROGRAMMED CELL DEATH-L1 SIGNALING FOR DEVELOPMENT OF ESOPHAGOGASTRIC JUNCTION ADENOCARCINOMA THROUGH SYSTEMIC INFLAMMATION AGAINST LIPOPOLYSACCHARIDE PERMEATED FROM DYSBIOTIC GUT

    Toru Tamahara

    GASTROENTEROLOGY　2024

  21. Design and Progress of Child Health Assessments at Community Support Centers in the Birth and Three-Generation Cohort Study of the Tohoku Medical Megabank Project.

    Tomoko Kobayashi, Mika Kobayashi, Naoko Minegishi, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Tomomi Onuma, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Akira Uruno, Junichi Sugawara, Kichiya Suzuki, Eiichi N Kodama, Yohei Hamanaka, Naho Tsuchiya, Mana Kogure, Naoki Nakaya, Makiko Taira, Mika Sakurai-Yageta, Toru Tamahara, Junko Kawashima, Maki Goto, Akihito Otsuki, Ritsuko Shimizu, Soichi Ogishima, Hiroaki Hashizume, Fuji Nagami, Tomohiro Nakamura, Atsushi Hozawa, Tadao Kobayashi, Nobuo Fuse, Shinichi Kuriyama, Shigeo Kure, Masayuki Yamamoto

    The Tohoku journal of experimental medicine　259　(2)　93-105　2023/01/20

    DOI： 10.1620/tjem.2022.J103 　

  22. Phenotype Harmonization in the GLIDE2 Oral Health Genomics Consortium

    Toru Tamahara

    JOURNAL OF DENTAL RESEARCH　101　(11)　1408-1416　2022/10

    DOI： 10.1177/00220345221109775 　

    ISSN： 0022-0345

    eISSN： 1544-0591

  23. Dental care using an oral appliance to support hematopoietic stem cell transplantation for NK/T cell lymphoma, nasal type, with palatal perforation.

    Hanako Suenaga, Masahiro Iikubo, Toru Tamahara, Mina Dodo, Chris Peck, Takeyoshi Koseki, Hideo Harigae, Keiichi Sasaki

    Journal of prosthodontic research　66　(2)　353-356　2021/07/15

    DOI： 10.2186/jpr.JPR_D_20_00270 　

  24. 東北大学病院周術期口腔支援センター・予防歯科における紹介患者の動向

    百々 美奈, 岩永 賢二郎, 玉原 亨, 飯嶋 若菜, 石河 理紗, 猪狩 真奈, 渡辺 俊吾, 田中 篤史, 加藤 翼, 丹田 奈緒子, 飯久保 正弘, 小関 健由

    東北大学歯学雑誌　37/38/39　(2/1-2/1)　47-47　2020/06

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  25. Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project. Peer-reviewed

    Akito Tsuboi, Hiroyuki Matsui, Naru Shiraishi, Takahisa Murakami, Akihito Otsuki, Junko Kawashima, Tomomi Kiyama, Toru Tamahara, Maki Goto, Shihoko Koyama, Junichi Sugawara, Eiichi N Kodama, Hirohito Metoki, Atsushi Hozawa, Shinichi Kuriyama, Hiroaki Tomita, Masahiro Kikuya, Naoko Minegishi, Kichiya Suzuki, Seizo Koshiba, Gen Tamiya, Nobuo Fuse, Yuichi Aoki, Takako Takai-Igarashi, Soichi Ogishima, Tomohiro Nakamura, Mika Sakurai-Yageta, Fuji Nagami, Kengo Kinoshita, Shigeo Kure, Ritsuko Shimizu, Keiichi Sasaki, Masayuki Yamamoto

    The Tohoku journal of experimental medicine　251　(2)　97-115　2020/06

    DOI： 10.1620/tjem.251.97 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  26. Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project. International-journal

    Sakae Saito, Yuichi Aoki, Toru Tamahara, Maki Goto, Hiroyuki Matsui, Junko Kawashima, Inaho Danjoh, Atsushi Hozawa, Shinichi Kuriyama, Yoichi Suzuki, Nobuo Fuse, Shigeo Kure, Riu Yamashita, Osamu Tanabe, Naoko Minegishi, Kengo Kinoshita, Akito Tsuboi, Ritsuko Shimizu, Masayuki Yamamoto

    Frontiers in cellular and infection microbiology　10　604596-604596　2020

    DOI： 10.3389/fcimb.2020.604596 　

  27. Design of the spacer for brachytherapy using 198Au grain for carcinoma of the tongue as a tool of perioperative oral management. Peer-reviewed

    Hanako Suenaga, Toru Tamahara, Mina Dodo, Toshimitsu Murakami, Satoshi Sasaki, Kengo Ito, Keiichi Jingu, Takeyoshi Koseki, Keiichi Sasaki

    Journal of prosthodontic research　62　(4)　518-521　2018/10

    DOI： 10.1016/j.jpor.2018.07.002 　

    ISSN： 1883-1958

    eISSN： 2212-4632

  28. The mTOR-Bach2 Cascade Controls Cell Cycle and Class Switch Recombination during B Cell Differentiation. International-journal Peer-reviewed

    Toru Tamahara, Kyoko Ochiai, Akihiko Muto, Yukinari Kato, Nicolas Sax, Mitsuyo Matsumoto, Takeyoshi Koseki, Kazuhiko Igarashi

    Molecular and cellular biology　37　(24)　2017/12/15

    DOI： 10.1128/MCB.00418-17 　

    ISSN： 0270-7306

    eISSN： 1098-5549

  29. [Extensive analysis of protein phosphorylation: An example of transcription factor Bach2].

    Hiroki Shima, Ryo Ando, Toru Tamahara, Kazuhiko Igarashi

    Seikagaku. The Journal of Japanese Biochemical Society　88　(1)　31-5　2016/02

    Publisher:

    ISSN： 0037-1017

  30. The Transcription Factor Bach2 Is Phosphorylated at Multiple Sites in Murine B Cells but a Single Site Prevents Its Nuclear Localization. International-journal Peer-reviewed

    Ryo Ando, Hiroki Shima, Toru Tamahara, Yoshihiro Sato, Miki Watanabe-Matsui, Hiroki Kato, Nicolas Sax, Hozumi Motohashi, Keiko Taguchi, Masayuki Yamamoto, Masaki Nio, Tatsuya Maeda, Kyoko Ochiai, Akihiko Muto, Kazuhiko Igarashi

    The Journal of biological chemistry　291　(4)　1826-1840　2016/01/22

    DOI： 10.1074/jbc.M115.661702 　

    ISSN： 0021-9258

    eISSN： 1083-351X

  31. Measuring Flow Rates of Saliva for Accurate Diagnosis of Xerostomia Peer-reviewed

    Eiko Yoshida, Jun Suzuki, Emi Ito, Ryoichi Hosokawa, Naoko Tanda, Toru Tamahara, Jun Harako, Katuhiko Taura, Takeyosuhi Koseki

    Interface Oral Health Science 2011　223-225　2012

    Publisher: Springer Japan

    DOI： 10.1007/978-4-431-54070-0_63 　

  32. Collaboration of Medical and Dental Facilities Promotes Oral Health Care in Hospitals Peer-reviewed

    Jun Harako, Toru Tamahara, Ryoichi Hosokawa, Kazunori Kimura, Moritoshi Komagata, Koji Hanaoka, Seiichi Aonuma, Fusako Okuya, Kaoru Itagaki, Yukiko Akai, Kazuhiko Tamura, Hidetoshi Sonobe, Takeyoshi Koseki

    Interface Oral Health Science 2011　297-299　2012

    Publisher: Springer Japan

    DOI： 10.1007/978-4-431-54070-0_88 　

  33. Promotion of Professional Oral Care for Hospitalized and Home-Care Patients Peer-reviewed

    Toru Tamahara, Jun Harako, Ryoichi Hosokawa, Kazunori Kimura, Moritoshi Komagata, Koji Hanaoka, Seiichi Aonuma, Fusako Okuya, Kaoru Itagaki, Yukiko Akai, Kazuhiko Tamura, Hidetoshi Sonobe, Takeyoshi Koseki

    Interface Oral Health Science 2011　309-311　2012

    Publisher: Springer Japan

    DOI： 10.1007/978-4-431-54070-0_92 　

Show all ︎Show first 5

Misc. 58

  1. 消化器疾患における腸内細菌叢の解析;病態解明と診療展開 食道胃接合部癌発育伸展におけるdysbiosis・腸管粘膜バリア傷害の役割

    須藤 洸一郎, 宇野 要, 玉原 亨, 草野 啓介, 田邊 瑞樹, 菅野 武, 浅野 直喜, 小池 智幸, 正宗 淳

    日本消化器病学会雑誌　121　(臨増総会)　A44-A44　2024/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  2. 唾液タンパク組成と全身状態の関連性

    渡辺俊吾, 岩永賢二郎, 百々美奈, 飯嶋若菜, 石河理紗, 玉原亨, 加藤翼, 織部令奈, 丹田奈緒子, 小関健由

    口腔衛生学会雑誌　69　(増刊)　172-172　2019/04

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  3. 術後性開口障害患者にかいくんを用いた開口訓練の効果について

    田中篤史, 岩永賢二郎, 玉原亨, 百々美奈, 飯嶋若菜, 猪狩真奈, 渡辺俊吾, 加藤翼, 清信仁, 丹田奈緒子, 小関健由

    日本歯科医療管理学会雑誌　53　(1)　75　2018/06/15

    ISSN： 0387-5687

  4. 東北大学病院周術期口腔支援センターおよび予防歯科における診療の動向

    田中 篤史, 岩永 賢二郎, 玉原 亨, 百々 美奈, 飯嶋 若菜, 猪狩 真奈, 渡辺 俊吾, 加藤 翼, 丹田 奈緒子, 小関 健由

    みちのく歯学会雑誌　48　(1-2)　26-27　2017/12

    Publisher: 東北地区歯科医学会

    ISSN： 0385-0099

  5. 東北大学病院周術期口腔支援センターおよび予防歯科における診療の動向

    田中篤史, 岩永賢二郎, 玉原亨, 百々美奈, 飯嶋若菜, 猪狩真奈, 渡辺俊吾, 加藤翼, 丹田奈緒子, 小関健由

    みちのく歯学会雑誌　48　(1-2)　26-27　2017/12

    Publisher: 東北地区歯科医学会

    ISSN： 0385-0099

  6. 半夏瀉心湯による口腔粘膜炎抑制の新たな作用機序の報告

    玉原亨, 丹田奈緒子, 佐久間陽子, 飯嶋若菜, 猪狩真奈, 百々美奈, 渡辺俊吾, 田中篤史, 波田野悠夏, 伊藤恵美, 高橋久美子, 細川亮一, 小関健由

    口腔衛生学会雑誌　67　(4)　312-312　2017/10

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  7. 東日本大震災後の東北大学病院口臭外来受診動態

    丹田奈緒子, 玉原亨, 佐久間陽子, 飯嶋若菜, 猪狩真奈, 百々美奈, 渡辺俊吾, 田中篤史, 波多野悠夏, 伊藤恵美, 高橋久美子, 細川亮一, 小関健由

    口腔衛生学会雑誌　67　(4)　312-312　2017/10

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  8. 東北大学病院周術期口腔支援センターにおける初診患者の動向

    百々 美奈, 玉原 亨, 飯嶋 若菜, 猪狩 真奈, 渡辺 俊吾, 田中 篤史, 加藤 翼, 佐久間 陽子, 丹田 奈緒子, 山内 健介, 半田 慶介, 下田 元, 小関 健由, 細川 亮一, 飯久保 正弘

    東北大学歯学雑誌　35/36　(2/1)　76-79　2017/06

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  9. 東北大学病院周術期口腔支援センターにおける初診患者の動向

    百々美奈, 玉原亨, 飯嶋若菜, 猪狩真奈, 渡辺俊吾, 田中篤史, 加藤翼, 佐久間陽子, 丹田奈緒子, 山内健介, 半田慶介, 下田元, 小関健由, 小関健由, 小関健由, 細川亮一, 飯久保正弘

    東北大学歯学雑誌　35/36　(2/1)　76-79　2017/06

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  10. 東北大学病院周術期口腔支援センターにおける診療の動向

    百々美奈, 玉原亨, 渡辺俊吾, 田中篤史, 加藤翼, 畠山博之, 高橋志麻, 石川元洋, 高柳久与, 丹田奈緒子, 小関健由

    口腔衛生学会雑誌　67　(増刊)　134-134　2017/04

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  11. 地域住民の口腔保健の実施状況の10年間の経時変化

    渡辺俊吾, 玉原亨, 百々美奈, 田中篤史, 加藤翼, 畠山博之, 高橋志麻, 石川元洋, 高柳久与, 丹田奈緒子, 小関健由

    口腔衛生学会雑誌　67　(増刊)　135-135　2017/04

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  12. 半夏瀉心湯は頭頸部化学放射線治療由来の口腔粘膜炎を抑制する

    玉原亨, 細川亮一, 丹田奈緒子, 佐久間陽子, 飯嶋若菜, 百々美奈, 伊藤恵美, 高橋久美子, 小関健由

    みちのく歯学会雑誌　47　(1-2)　81-82　2016/12

    Publisher: 東北地区歯科医学会

    ISSN： 0385-0099

  13. 頭頸部がんに対する化学放射線療法に伴う口腔粘膜炎に対する半夏瀉心湯の基礎研究と臨床的効果

    細川亮一, 細川亮一, 玉原亨, 丹田奈緒子, 佐久間陽子, 飯嶋若菜, 百々美奈, 渡辺俊介, 伊藤恵美, 小関健由

    和漢医薬学会学術大会要旨集　33回　102-103　2016/08

    Publisher: (一社)和漢医薬学会

  14. The role of dental team in perioperative management of oral function

    細川亮一, 細川亮一, 玉原亨, 小関健由

    Japanese Journal of Maxillo Facial Implants　15　(2)　71-76　2016/08

    Publisher: (公社)日本顎顔面インプラント学会

    ISSN： 1347-894X

  15. 病院における多職種連携による口腔のケアと管理の推進について

    玉原亨, 細川亮一, 細川亮一, 細川亮一, 丹田奈緒子, 末永華子, 佐久間陽子, 管崎将樹, 飯嶋若菜, 百々美奈, 加藤翼, 渡辺俊吾, 伊藤恵美, 高橋久美子, 小関健由, 小関健由

    東北大学歯学雑誌　34/35　(2/1)　13-26　2016/06

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  16. 東日本大震災前後の歯科医師の社会活動の取り組みについて

    杉山 美幸, 百々 美奈, 加藤 翼, 玉原 亨, 飯島 若菜, 末永 華子, 菅崎 将樹, 佐久間 陽子, 丹田 奈緒子, 伊藤 恵美, 高橋 久美子, 坪井 明人, 土谷 昌広, 細川 亮一, 小関 健由

    口腔衛生学会雑誌　66　(3)　345-346　2016/04

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  17. 東北大学病院予防歯科におけるBRONJ患者の動向

    加藤翼, 細川亮一, 丹田奈緒子, 末永華子, 菅崎将樹, 佐久間陽子, 飯嶋若菜, 玉原亨, 百々美奈, 福井玲子, 山崎佐千子, 笠原千秋, 伊藤恵美, 高橋久美子, 手代木史枝, 馬目麻衣, 小関健由

    口腔衛生学会雑誌　66　(3)　345-345　2016/04

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  18. エコチル追加調査による妊娠中の夫婦の口腔保健状況について

    小関健由, 石川元洋, 玉原亨, 百々美奈, 加藤翼, 高橋久美子, 細川亮一, 丹田奈緒子, 末永華子, 飯島若菜, 菅崎将樹, 佐久間陽子, 伊藤恵美, 有馬隆博

    宮城県公衆衛生学会会誌　(48)　12-12　2016/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  19. Debriefs and advices of the dentists who experienced the post-quake reconstruction from the Great East Japan Earthquake

    杉山美幸, 玉原亨, 百々美奈, 加藤翼, 渡辺俊吾, 伊藤恵美, 土谷昌広, 坪井明人, 小関健由

    感性福祉研究所年報　(17)　261-269　2016/03

    Publisher: 東北福祉大学感性福祉研究所

    ISSN： 1344-9966

    More details Close

    東日本大震災時の歯科医師の活動について質問紙調査を実施した。平成25年8月時点の宮城県歯科医師会の会員一斉通知に質問紙票を同封し、歯科医師会会員1143名に配布した。また、東北大学所属の歯科医師にも質問紙調査を実施し、学内便で回収した。歯科医師会会員より224名、大学関係者から102名の回答が得られた。これから歯科医師がより取り組まなければならない社会活動として、「口腔保健啓発の推進」「子どもの口腔保健の推進」「高齢者・障害者の口腔保健の推進」「歯科医療の充実」「地域連携の推進」「医療全般の推進」などがあげられた。「東日本大震災を経験した歯科医師として、思うところを自由記載してください」との質問に対しては、「歯科医療や医療に関する感想」「歯科医療界・医療界等への提言」「身元確認作業の感想」「人生観について」「感謝の気持ち」「生活の変化に関する感想」の、大きく七つに分類できる記述が確認できた。

  20. ビッグデータから読み解く生命現象 単一タンパク質の徹底的リン酸化解析と機能特定:転写因子Bach2を例に

    島弘季, 安藤亮, 玉原亨, 五十嵐和彦

    生化学　88　(1)　31-35　2016/02

    Publisher: (公社)日本生化学会

    DOI： 10.14952/SEIKAGAKU.2016.880031 　

    ISSN： 0037-1017

  21. 「赤ちゃんとママのむし歯予防教室」の歯科保健学習効果について 宮城県妊娠中からの歯科保健モデル事業から

    根本充康, 細谷仁憲, 山本壽一, 新沼康弘, 鈴木宏明, 戸田愼治, 佐藤文彦, 佐々木隆二, 森拓也, 細川亮一, 丹田奈緒子, 末永華子, 菅崎将樹, 佐久間陽子, 飯島若菜, 菊地瑞穂, 玉原亨, 百々美奈, 加藤翼, 伊藤恵美, 高橋久美子, 戸田康子, 小関健由

    みちのく歯学会雑誌　46　(1-2)　60-61　2015/12

    Publisher: 東北地区歯科医学会

    ISSN： 0385-0099

  22. 1歳6ヵ月児の母親の育児時の歯科保健意識の変化とう蝕発生との関連

    戸田 康子, 玉原 亨, 伊藤 恵美, 高橋 久美子, 手代木 史枝, 菅崎 将樹, 佐久間 陽子, 百々 美奈, 加藤 翼, 末永 華子, 丹田 奈緒子, 細川 亮一, 小関 健由

    口腔衛生学会雑誌　65　(2)　204-204　2015/04

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  23. 東日本大震災被災地の震災後の学校歯科保健の動向について

    手代木史枝, 伊藤恵美, 戸田康子, 高橋久美子, 菅崎将樹, 佐久間陽子, 玉原亨, 百々美奈, 加藤翼, 末永華子, 丹田奈緒子, 細川亮一, 小関健由

    口腔衛生学会雑誌　65　(2)　258-258　2015/04

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  24. 東北大学病院における緩和医療に関する学生ならびに歯科医師に対する意識調査

    細川亮一, 伊藤恵美, 手代木史枝, 丹田奈緒子, 菅崎将樹, 末永華子, 百々美奈, 佐久間陽子, 加藤翼, 玉原亨, 小関健由

    口腔衛生学会雑誌　65　(2)　240-240　2015/04

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  25. 1歳6か月児の母親の育児時の歯科保健意識の変化とう蝕発生との関連

    戸田康子, 玉原亨, 伊藤恵美, 高橋久美子, 手代木史枝, 菅崎将樹, 佐久間陽子, 百々美奈, 加藤翼, 末永華子, 丹田奈緒子, 細川亮一, 小関健由

    口腔衛生学会雑誌　65　(2)　204-204　2015/04

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  26. 1歳6ヵ月児のう蝕発生に関与する妊娠中からの母親の意識と行動 妊娠中からの歯科保健モデル事業報告から(1)

    根本 充康, 細谷 仁憲, 山本 壽一, 新沼 康弘, 鈴木 宏明, 戸田 愼治, 佐藤 文彦, 佐々木 隆二, 細川 亮一, 丹田 奈緒子, 末永 華子, 菅崎 将樹, 佐久間 陽子, 飯島 若菜, 菊池 瑞穂, 玉原 亨, 百々 美奈, 加藤 翼, 伊藤 恵美, 高橋 久美子, 手代木 史枝, 戸田 康子, 小関 健由

    口腔衛生学会雑誌　65　(1)　58-59　2015/01

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  27. 妊娠時と1歳6ヵ月児の育児時の母親の歯科保健に関する意識と行動の変化 妊娠中からの歯科保健モデル事業報告から(2)

    戸田 康子, 細川 亮一, 丹田 奈緒子, 末永 華子, 菅崎 将樹, 佐久間 陽子, 飯島 若菜, 菊池 瑞穂, 玉原 亨, 百々 美奈, 加藤 翼, 伊藤 恵美, 高橋 久美子, 手代木 史枝, 細谷 仁憲, 山本 壽一, 新沼 康弘, 鈴木 宏明, 戸田 愼治, 佐藤 文彦, 佐々木 隆二, 根本 充康, 小関 健由

    口腔衛生学会雑誌　65　(1)　59-59　2015/01

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  28. 開口障害と多発性う蝕と放射線性顎骨壊死の重篤な晩期有害事象

    原 美里, 笠原 千秋, 山崎 佐千子, 福井 玲子, 山田 桂子, 手代木 史枝, 高橋 久美子, 伊藤 恵美, 細川 亮一, 丹田 奈緒子, 末永 華子, 菅崎 将樹, 佐久間 陽子, 飯島 若菜, 菊池 瑞穂, 玉原 亨, 百々 美奈, 加藤 翼, 小関 健由

    口腔衛生学会雑誌　65　(1)　59-60　2015/01

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  29. 農業地帯住民の歯科保健に関する意識調査について

    百々美奈, 高橋文一, 木村俊春, 山崎達見, 庄司達雄, 野田清一, 伏見行則, 白石信也, 近江浩昭, 曽根憲一, 虻江勝, 久保圭, 渋谷芳和, 玉原亨, 小野瑞穂, 加藤翼, 細川亮一, 丹田奈緒子, 吉田英子, 伊藤恵美, 小関健由

    口腔衛生学会雑誌　65　(1)　55-56　2015/01

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  30. 東北大学病院におけるがん治療と歯科処置

    小野瑞穂, 玉原亨, 百々美奈, 加藤翼, 福井玲子, 原美里, 山崎佐千子, 鈴木寿子, 細川亮一, 丹田奈緒子, 吉田英子, 末永華子, 飯嶋若菜, 伊藤恵美, 小関健由

    口腔衛生学会雑誌　65　(1)　54-54　2015/01

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  31. 妊娠時と1歳6か月児の育児時の母親の歯科保健に関する意識と行動の変化―妊娠中からの歯科保健モデル事業報告から(2)―

    戸田康子, 細川亮一, 丹田奈緒子, 末永華子, 菅崎将樹, 佐久間陽子, 飯島若菜, 菊池瑞穂, 玉原亨, 百々美奈, 加藤翼, 伊藤恵美, 高橋久美子, 手代木史枝, 細谷仁憲, 山本壽一, 新沼康弘, 鈴木宏明, 戸田愼治, 佐藤文彦, 佐々木隆二, 根本充康, 小関健由

    口腔衛生学会雑誌　65　(1)　59-59　2015/01

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  32. 「赤ちゃんとママのむし歯予防」教室受講者の歯科保健に関する意識と行動―妊娠中からの歯科保健モデル事業報告から(3)―

    菊池瑞穂, 細川亮一, 丹田奈緒子, 末永華子, 菅崎将樹, 佐久間陽子, 飯島若菜, 玉原亨, 百々美奈, 加藤翼, 伊藤恵美, 高橋久美子, 手代木史枝, 細谷仁憲, 山本壽一, 新沼康弘, 鈴木宏明, 戸田愼治, 佐藤文彦, 佐々木隆二, 根本充康, 小関健由

    口腔衛生学会雑誌　65　(1)　59-59　2015/01

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  33. 開口障害と多発性うしょくと放射線性顎骨壊死の重篤な晩期有害事象

    原美里, 笠原千秋, 山崎佐千子, 福井玲子, 山田桂子, 手代木史枝, 高橋久美子, 伊藤恵美, 細川亮一, 丹田奈緒子, 末永華子, 菅崎将樹, 佐久間陽子, 飯島若菜, 菊池瑞穂, 玉原亨, 百々美奈, 加藤翼, 小関健由

    口腔衛生学会雑誌　65　(1)　59-60　2015/01

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  34. 1歳6カ月児のうしょく発生に関与する妊娠中からの母親の意識と行動―妊娠中からの歯科保健モデル事業報告から(1)―

    根本充康, 細谷仁憲, 山本壽一, 新沼康弘, 鈴木宏明, 戸田愼治, 佐藤文彦, 佐々木隆二, 細川亮一, 丹田奈緒子, 末永華子, 菅崎将樹, 佐久間陽子, 飯島若菜, 菊池瑞穂, 玉原亨, 百々美奈, 加藤翼, 伊藤恵美, 高橋久美子, 手代木史枝, 戸田康子, 小関健由

    口腔衛生学会雑誌　65　(1)　58-59　2015/01

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  35. 子どもの歯科健康診断情報収録システムの開発とデータベース化の取り組み

    加藤翼, 伊藤恵美, 玉原亨, 百々美奈, 小野瑞穂, 細川亮一, 丹田奈緒子, 吉田英子, 末永華子, 飯嶋若菜, 小関健由

    口腔衛生学会雑誌　65　(1)　56-56　2015/01

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  36. 頭頸部癌に対する開口訓練の効果の検証

    吉田英子, 細川亮一, 丹田奈緒子, 末永華子, 菅崎将樹, 佐久間陽子, 飯嶋若菜, 菊池瑞穂, 玉原亨, 百々美奈, 加藤翼, 山崎佐千子, 原美里, 笠原千秋, 福井玲子, 伊藤恵美, 高橋久美子, 手代木史枝, 小関健由

    みちのく歯学会雑誌　45　(1-2)　7-8　2014/12

    Publisher: 東北地区歯科医学会

    ISSN： 0385-0099

  37. 東北大学病院予防歯科におけるがん患者の周術期口腔支援

    加藤翼, 細川亮一, 丹田奈緒子, 末永華子, 菅崎将樹, 佐久間陽子, 飯嶋若菜, 菊池瑞穂, 吉田英子, 玉原亨, 百々美奈, 山崎佐千子, 原美里, 笠原千秋, 福井玲子, 伊藤恵美, 高橋久美子, 手代木史枝, 小関健由

    みちのく歯学会雑誌　45　(1-2)　74-75　2014/12

    Publisher: 東北地区歯科医学会

    ISSN： 0385-0099

  38. 妊産婦の出産前後における口腔保健の行動・意識調査

    戸田康子, 伊藤恵美, 玉原亨, 加藤翼, 高橋久美子, 小関健由

    日本歯科衛生学会雑誌　9　(1)　217-217　2014/08

    Publisher: 日本歯科衛生学会

    ISSN： 1884-5193

  39. 口の健康と認知に関する歯科からの話題―健康の基は食べることと話すこと,口の健康から全身の健康へ―

    小関健由, 玉原亨, 百々美奈, 加藤翼

    認知神経科学　16　(1)　1-8　2014/05

    Publisher: 認知神経科学会

    DOI： 10.11253/ninchishinkeikagaku.16.1 　

    ISSN： 1344-4298

    eISSN： 1884-510X

  40. Topics of oral health and cognitive neuroscience from the viewpoint of dentistry : The basis of health is eating and talking : Oral health leads general health

    小関 健由, 玉原 亨, 百々 美奈

    認知神経科学　16　(1)　1-8　2014/05

    Publisher: 認知神経科学会

    ISSN： 1344-4298

  41. 東北大学病院におけるがん支持療法としての口腔機能管理の取り組み

    加藤翼, 細川亮一, 玉原亨, 吉田英子, 丹田奈緒子, 菅崎将樹, 末永華子, 百々美奈, 小野瑞穂, 伊藤恵美, 小関健由

    口腔衛生学会雑誌　64　(2)　235-235　2014/04

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  42. 転写因子Bach2はmTORによって制御される

    玉原亨, 佐藤好宏, 落合恭子, 五十嵐和彦

    日本分子生物学会年会プログラム・要旨集(Web)　37th　2P-0731 (WEB ONLY)　2014

  43. Topics of oral health and cognitive neuroscience from the viewpoint of dentistry - The basis of health is eating and talking ; Oral health leads general health -

    Koseki Takeyoshi, Tamahara Toru, Dohdoh Nami, Kato Tubasa

    Japanese Journal of Cognitive Neuroscience　16　(1)　1-8　2014

    Publisher: Japanese Society of Cognitive Neuroscience

    DOI： 10.11253/ninchishinkeikagaku.16.1 　

    ISSN： 1344-4298

    More details Close

    Healthy new born babies give the first cry and nurse themselves on mother's breasts at the beginning of their lives. Grown-up's mouth supports healthy lifestyle to enjoy eating, talking and laughing. When the last moment comes, leaving the last words to say good-bye helps their love ones and themselves rest in peace. Mouth works to take nutrition by eating meals, to reach to understand each other by talking, to express emotion ; delight, anger, sorrow and pleasure. The mouth supports their life from the birth until the end of their life as a human. According to Penfield's brain mapping, sense and move of mouth occupies 1/ 3 of whole brain field. From the discrimination distance between two points on the body surface, mouth is one of the most sensitive parts of the body such like hands. Recently, it is drawing attention that the oral health can be threatening to general health. Periodontitis, a gingival inflammation, leads to several health problems such as endocarditis, diabetes, premature delivery and a low birth-weight infant, by spreading oral bacteria or inflammatory cytokines through peripheral blood circulation. Erroneous swallowing of filthy saliva also develops aspiration pneumonia. Responding to these problems, it is recommended the establishment of team medical care including dentist and dental hygienist, the promotion of perioperative oral health management and oral health care of elderly. The distance between dental care and medical care are getting closer. This article introduces the importance of oral function by showing some references of oral health from the dentist's point of view.

  44. 妊産婦の出産前後における口腔保健の意識および行動の変化

    伊藤恵美, 玉原亨, 吉田英子, 丹田奈緒子, 細川亮一, 大内康宏, 小関健由

    日本歯科衛生学会雑誌　8　(1)　164-164　2013/08

    Publisher: 日本歯科衛生学会

    ISSN： 1884-5193

  45. 情報入力を省力化した歯科健診情報管理システムの構築

    伊藤恵美, 玉原亨, 細川亮一, 吉田英子, 丹田奈緒子, 小島健, 斉藤純一, 小関健由

    口腔衛生学会雑誌　63　(4)　362-363　2013/07

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  46. 脱水素酵素濃度により歯周疾患スクリーニングの年齢別成績

    平田正嗣, 玉原亨, 吉田英子, 梁川誠郎, 大山治, 山崎尚哉, 小菅玲, 大内康弘, 村上正博, 郷家茂樹, 木村一則, 高野友幸, 田鎖利明, 村上廣一, 馬場智彦, 細川亮一, 丹田奈緒子, 伊藤恵美, 小関健由, 長田純一

    口腔衛生学会雑誌　63　(4)　363-364　2013/07

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  47. 東北大学病院における周術期口腔機能管理

    吉田英子, 玉原亨, 細川亮一, 丹田奈緒子, 小島健, 福井玲子, 佐藤由美子, 高橋美里, 小野ゆかり, 伊藤恵美, 小関健由

    口腔衛生学会雑誌　63　(4)　364-364　2013/07

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  48. P-72 東北大学病院における口腔ケアの現状と症例(ポスター)

    吉田 英子, 玉原 亨, 細川 亮一, 丹田 奈緒子, 伊藤 恵美, 佐藤 由美子, 小関 健由

    口腔衛生学会雑誌　63　(2)　203-203　2013/04/30

    Publisher: 有限責任中間法人日本口腔衛生学会

    ISSN： 0023-2831

  49. P-74 歯科衛生士と看護師の協働の推進に関する質問紙調査(ポスター)

    吉田 志麻, 玉原 亨, 細川 亮一, 丹田 奈緒子, 吉田 英子, 伊藤 恵美, 小関 健由

    口腔衛生学会雑誌　63　(2)　204-204　2013/04/30

    Publisher: 有限責任中間法人日本口腔衛生学会

    ISSN： 0023-2831

  50. 東北大学病院における口腔ケアの現状と症例

    吉田英子, 玉原亨, 細川亮一, 丹田奈緒子, 伊藤恵美, 佐藤由美子, 小関健由

    口腔衛生学会雑誌　63　(2)　203-203　2013/04

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  51. 歯科衛生士と看護師の協働の推進に関する質問紙調査

    吉田志麻, 玉原亨, 細川亮一, 丹田奈緒子, 吉田英子, 伊藤恵美, 小関健由

    口腔衛生学会雑誌　63　(2)　204-204　2013/04

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  52. 刺激唾液分泌量と口腔内健康指標との関連

    吉田英子, 細川亮一, 丹田奈緒子, 伊藤恵美, 鈴木淳, 玉原亨, 小島健, 田浦勝彦, 小関健由

    東北大学歯学雑誌　31　(2)　71-78　2012/12

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  53. 全身状態と口腔内因子の刺激唾液流出量との関連について

    吉田英子, 玉原亨, 細川亮一, 伊藤恵美, 丹田奈緒子, 斎藤恵一, 田浦勝彦, 小関健由

    口腔衛生学会雑誌　62　(2)　228-228　2012/04

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  54. 東北大学病院における病棟患者における口腔ケアの臨床的検討

    玉原亨, 細川亮一, 伊藤恵美, 吉田英子, 丹田奈緒子, 小関健由

    口腔衛生学会雑誌　62　(2)　213-213　2012/04

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  55. 若手研究者が踏み出した健康社会への一歩 日韓のフロリデーション教育への取り組みの違い

    玉原 亨

    口腔衛生学会雑誌　61　(4)　398-398　2011/08

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  56. 東北6県における集団フッ化物洗口の実態 2010

    田浦勝彦, 鍛治山徹, 五十嵐雄一, 田村光平, 佐藤勤一, 斎藤愼一, 栃内圭子, 黒田雅行, 田口千恵子, 木本一成, 境脩, 相田潤, 玉原亨, 原子惇, 鈴木淳, 細川亮一, 小関健由

    みちのく歯学会雑誌　41　(1-2)　71-72　2010/12

    Publisher: 東北地区歯科医学会

    ISSN： 0385-0099

  57. モンテカルロ法を用いた一日あたりの食事からのフッ化物摂取量の推計

    玉原亨, 若栗真太郎, 相田潤, 小坂健

    口腔衛生学会雑誌　60　(4)　381-381　2010/08

    Publisher: (一社)日本口腔衛生学会

    ISSN： 0023-2831

  58. 標準的検診法と精度管理や医療経済的効果に関する研究 標準的検診法と精度管理や医療経済効果に関する研究

    小坂健, 相田潤, 玉原亨

    標準的検診法と精度管理や医療経済的効果に関する研究 平成20年度 総括研究報告書　39-41　2009

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Presentations 2

  1. Hangeshashinto prevents oral mucositis under chemotherapy and radiotherapy to head and neck cancer International-presentation

    Toru Tamahara

    The Multinational Association of Supportive Care in Cancer (MASCC)　2016/06/23

  2. A step toward a healthy society initiated by young researchers Invited

    Toru Tamahara

    Japanese society for dental health　2011/10/09

Industrial Property Rights 2

  1. バンコマイシン耐性腸球菌の感染症を予防又は治療するための医薬及び腸内細菌叢のα-多様性向上剤

    ▲高▼山 真, 鈴木 聡子, 菊地 章子, 有田 龍太郎, 石井 正, 青木 裕一, 玉原 亨, 清水 律子

    Property Type: Patent

  2. 抗リン酸化Bach2抗体及び抗腫瘍免疫活性化剤のスクリーニング方法

    五十嵐 和彦, 武藤 哲彦, 落合 恭子, 島 弘季, 安藤 亮, 佐藤 好宏, 玉原 亨, 佐藤 勇樹

    Property Type: Patent

Research Projects 8

  1. Strategies to prevent Medication-Related Osteonecrosis of the Jaw focusing on the CXCR4 system and oral microbiome

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Hamamatsu University School of Medicine

    2024/04/01 - 2027/03/31

  2. Development of Innovative Oral Cancer Prediction Model Targeting Oral Bacterial Flora

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2024/04/01 - 2027/03/31

  3. Understanding Odontogenic Focal Infection and New Approach in Oral Management Based on Integrated Analysis of Clinical, Imaging, and Bacterial Flora

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2024/04/01 - 2027/03/31

  4. 口腔細菌叢をターゲットとした新たな周産期合併症予測モデルの開発

    玉原 亨

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 若手研究

    Institution: 東北大学

    2021/04/01 - 2024/03/31

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    本研究では周産期における口腔内細菌叢の変化に着目をし、周産期の口腔内細菌叢変化と周産期合併症の関連について探索をおこなう。この結果から、口腔内細菌叢をターゲットとした周産期合併症リスク予測モデルを構築し、比較的容易に介入できる口腔内環境の整備が周産期合併症のリスク軽減に寄与し得ることを明らかにする。具体的には、周産期の細菌叢の変動をUnifrac距離を用いて表現することで周産期合併症の原因となる口腔内細菌叢変動パターンを分離する。分離されたパターンおよびコホート調査における生理・生化学データを材料に機械学習をおこない、マルチモーダルベイジアンネットワークを構築することで、周産期合併症のリスク予想モデルを構築する。 269人の妊婦の唾液検体（807検体）の解析は既に終了しているため、本年度は歯垢検体（807検体）を用いて検体に含まれる細菌の16S rRNA配列の取得をおこなった。Miseqにより得られた16S rRNA配列から、QIIME2パイプラインに沿って各検体に含まれる細菌の組成を明らかにし、さらに検体間の細菌叢の変動をUnifrac距離を用いて算出した。また、周産期合併症に特有の歯垢細菌叢の時系列変化パターンの解析をおこなった。そして、唾液・歯垢それぞれの妊婦の周産期における口腔内細菌叢の変化をUnifrac距離を用いて表現し、周産期合併症の有無で重みを付けることによって時系列変化パターンを分離した。これら一連の分析から、唾液・歯垢ともに周産期特有のパターンを見出すことができ、さらに早産となる口腔細菌叢変化パターンがある可能性を示唆することができた。

  5. Elucidation of the mechanism and strategies of the new preventive methods on aneurysm formation by oral bacteria Competitive

    Tamahara Toru

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Early-Career Scientists

    Institution: Tohoku University

    2018/04 - 2021/03

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    We have obtained 20 aneurysm samples and successfully cultured the bacteria in 13 cases. Bacterial DNA was extracted from the colonies that appeared, and the full length 16S rRNA region was amplified, finally the bacteria was identified by DNA sequencing. As a result, pathogenic bacteria of periodontal disease was not detected in aortic aneurysms and other aortic diseases, while staphylococcus and Propionibacterium acnes, which are indigenous bacteria of the body surface and oral cavity, was often detected. In addition, we established a system to amplify bacterial DNA in aneurysms by PCR, and showed that the detection ability differs between the culture method and the PCR method.

  6. 歯周病菌による動脈瘤形成機序の解明および新たな予防法の開発 Competitive

    玉原亨

    Offer Organization: 公益財団法人富徳会

    System: 平成29年度研究者助成事業

    2017/08 - 2018/03

  7. The comprehensive survey for the risk factor of oral mucositis under the radiotherapy. Competitive

    Hosokawa Ryoichi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2015/04 - 2018/03

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    It is very important to prevent or reduce adverse events caused by the radiotherapy and chemotherapy for completing the treatment plan. Especially, the adverse events of head and neck cancer caused by radiotherapy are very severe. For instance, patients complain dry mouth and oral mucositis so on. Oral mucositis cause severe pain and reduce patient’s quality of life. It is very hard for patients to eat or talk due to the pain caused by oral mucositis. So it is requested to establish the methods inhibit oral mucositis during radiotherapy. In this study, we proposed the possibility to reduce the severity of oral mucositis using Hangeshasinto, which is one of traditional medicine in Japan in clinical study. Also we provide the mechanism how Hangeshasinto prevent oral mucositis by using cell culture experiments.

  8. relation with between priodontal bacteria and aneurythms Competitive

    Tamahara Toru

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Research Activity Start-up

    Institution: Tohoku University

    2015/08 - 2017/03

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    We extracted DNA from the aneurysms samples after beads crush was performed to them. We obtained the DNA solution which tried the DNA amplification of the region that encoded 16rRNA using PCR with obtained DNA solution. As a result, We obtained the DNA contained with not only the bacterial DNA but also the aneurysms wall, we examined annealing temperature, and single band was detected in 55.7 degrees Celsius in 30 times for an amplification cycle when we set it and, furthermore, determined what could completely remove the gram-positive and negative bacteria which lived in what we washed with hypochlorous acid with aneurysms sample before the culture from aneurysms wall to be aneurysmal, and to remove bacterial DNA in the blood which attached.

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