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Toru Tamahara

Section

Tohoku Medical Megabank Organization

Job title

Senior Assistant Professor

Degree

博士（歯学）（東北大学）

researchmap

https://researchmap.jp/teuchi-soba

J-GLOBAL ID

201901019415348078

Research History 6

2021/04 - Present

Tohoku University　Tohoku Medical Megabank Organization　Senior Associate Professor
2019/04 - Present

Tohoku University, Sendai, Japan　Tohoku Medical Megabank Organization　assistant professor
2017/04 - 2019/03

Tohoku University, Sendai, Japan　Graduate School of Dentistry　assistant professor
2016/04 - 2017/03

Tohoku University Hospital, Sendai, Japan　perioperative oral support center　assistant professor
2015/04 - 2016/03

Tohoku University Hospital, Sendai, Japan　Preventive dentistry　Clinical Fellow
2010/04 - 2011/03

Tohoku University Hospital, Sendai, Japan　Graduate Medical Education Center　Dental resident

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Education 2

Tohoku University, Sendai, Japan　Graduate School of Dentistry

2011/04 - 2015/03
Tohoku University, Sendai, Japan,　faculty of dentistry

2004/04 - 2010/03

Committee Memberships 2

公益財団法人８０２０推進財団　令和6年度歯科保健活動事業助成

2024/09 - 2025/03
財団法人富徳会　平成29年度研究者助成金支給者

2017/09 - 2018/03

Professional Memberships 2

日本口腔外科学会
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

Research Interests 8

metagenome
periodontitis
oral care
perioperative dentistry
Bach2
dentistry
transcriptional factor
oral mucositis

Research Areas 2

Life sciences / Molecular biology / biochemistry
Life sciences / Community dentistry / perioperatiove dentistry

Papers 21

Effect of Japanese traditional medication on males with diarrhea-predominant irritable bowel syndrome and gut microbiome: A single-arm prospective study

Ryutaro Arita, Shin Takayama, Toru Tamahara, Yuichi Aoki, Soichiro Kaneko, Akiko Kikuchi, Junko Kawashima, Yoshiyuki Kasahara, Kota Ishizawa, Ritsuko Shimizu, Tadashi Ishii

European Journal of Integrative Medicine　2025/09

DOI： 10.1016/j.eujim.2025.102512 　
Co-stimulation with high-fat diet and acidic bile salts may promote Warburg effect in gastric carcinogenesis around the squamo-columnar junction in Gan mice

Koichiro Sudo, Kaname Uno, Toru Tamahara, Naoki Asano, Keisuke Kusano, Mizuki Tanabe, Kouya Ogasawara, Takeshi Kanno, Tomoyuki Koike, Ritsuko Shimizu, Atsushi Masamune

American Journal of Physiology-Gastrointestinal and Liver Physiology　2025/04/17
Publisher: American Physiological Society
DOI： 10.1152/ajpgi.00305.2024 　

ISSN： 0193-1857

eISSN： 1522-1547

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Epidemiological studies demonstrated relationships between gastric cardia adenocarcinoma (GCA) and metabolic syndrome (MetS). We aimed to clarify mechanism underlying their relationship. To investigate whether systemic inflammation against high-fat diet (HFD)-related dysbiosis promotes Warburg effect in tumors at the squamo-columnar junction (SCJ), we applied K19-Wnt1/C2mE (Gan) mice, fed either HFD or control diet ± acidic bile salts (ABS) with/without clodronate liposomes (CLs), and in vitro studies using MKN7 cells with/without THP1-derived macrophages. Then, we assessed involvement of oxidative stress (OS) in Warburg effect by comparing between nuclear factor-erythroid 2-related factor 2 (Nrf2) knockout-Gan mice and Gan mice. Tumors with macrophage infiltration in HFD+ABS group were larger than in Control group. Gene Set Enrichment Analysis revealed enhancement of the OS signaling in tumor of HFD+ABS group. HFD+ABS group mice demonstrated induction of OS, Nqo1, TNFα, and Warburg effect in tumors and mucosal barrier dysfunction of dysbiotic gut. All of them were abolished with diminishing macrophage infiltration by additional CLs treatment. Stimulation with TNFα, but not ABS nor lipopolysaccharide, on MKN7 cells activated Warburg effect. In MKN7 cells co-cultured with the macrophages whose TNFa expression was induced by the lipopolysaccharide pretreatment, Warburg effect was enhanced in the TNFα concentration-dependent manners. In Nrf2 knockout-Gan mice, tumors shrank with reducing OS, TNFα, and Warburg effect, along with decreasing macrophage infiltration. Accordingly, MetS may develop GCA through the Nrf2-related Warburg effect under the TNFα stimulation from the macrophages activated by both local ABS exposure and systemic lipopolysaccharide exposure from leaky gut with HFD-related dysbiosis.
Hangeshashinto Increases the Resistance of Cells Against Cisplatin Cytotoxicity by Regulating the Cell Cycle

Toru Tamahara, Ryutaro Arita

Natural Product Communications　2025/03

DOI： 10.1177/1934578X251324404 　
Sequential Sampling of the Gastrointestinal Tract to Characterize the Entire Digestive Microbiome in Japanese Subjects

Kota Ishizawa, Toru Tamahara, Suguo Suzuki, Yutaka Hatayama, Bin Li, Michiaki Abe, Yuichi Aoki, Ryutaro Arita, Natsumi Saito, Minoru Ohsawa, Soichiro Kaneko, Rie Ono, Shin Takayama, Muneaki Shimada, Kazuki Kumada, Tomoyuki Koike, Atsushi Masamune, Ko Onodera, Tadashi Ishii, Ritsuko Shimizu, Takeshi Kanno

Microorganisms　12　(7)　1324-1324　2024/06/28
Publisher: MDPI AG
DOI： 10.3390/microorganisms12071324 　

eISSN： 2076-2607

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The gastrointestinal (GI) tract harbors trillions of microorganisms known to influence human health and disease, and next-generation sequencing (NGS) now enables the in-depth analysis of their diversity and functions. Although a significant amount of research has been conducted on the GI microbiome, comprehensive metagenomic datasets covering the entire tract are scarce due to cost and technical challenges. Despite the widespread use of fecal samples, integrated datasets encompassing the entire digestive process, beginning at the mouth and ending with feces, are lacking. With this study, we aimed to fill this gap by analyzing the complete metagenome of the GI tract, providing insights into the dynamics of the microbiota and potential therapeutic avenues. In this study, we delved into the complex world of the GI microbiota, which we examined in five healthy Japanese subjects. While samples from the whole GI flora and fecal samples provided sufficient bacteria, samples obtained from the stomach and duodenum posed a challenge. Using a principal coordinate analysis (PCoA), clear clustering patterns were identified; these revealed significant diversity in the duodenum. Although this study was limited by its small sample size, the flora in the overall GI tract showed unwavering consistency, while the duodenum exhibited unprecedented phylogenetic diversity. A visual heat map illustrates the discrepancy in abundance, with Fusobacteria and Bacilli dominating the upper GI tract and Clostridia and Bacteroidia dominating the fecal samples. Negativicutes and Actinobacteria were found throughout the digestive tract. This study demonstrates that it is possible to continuously collect microbiome samples throughout the human digestive tract. These findings not only shed light on the complexity of GI microbiota but also provide a basis for future research.
Accelerated plasma-cell differentiation in Bach2-deficient mouse B cells is caused by altered IRF4 functions. International-journal

Kyoko Ochiai, Hiroki Shima, Toru Tamahara, Nao Sugie, Ryo Funayama, Keiko Nakayama, Tomohiro Kurosaki, Kazuhiko Igarashi

The EMBO journal　2024/04/11

DOI： 10.1038/s44318-024-00077-6 　

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Transcription factors BACH2 and IRF4 are both essential for antibody class-switch recombination (CSR) in activated B lymphocytes, while they oppositely regulate the differentiation of plasma cells (PCs). Here, we investigated how BACH2 and IRF4 interact during CSR and plasma-cell differentiation. We found that BACH2 organizes heterochromatin formation of target gene loci in mouse splenic B cells, including targets of IRF4 activation such as Aicda, an inducer of CSR, and Prdm1, a master plasma-cell regulator. Release of these gene loci from heterochromatin in response to B-cell receptor stimulation was coupled to AKT-mTOR pathway activation. In Bach2-deficient B cells, PC genes' activation depended on IRF4 protein accumulation, without an increase in Irf4 mRNA. Mechanistically, a PU.1-IRF4 heterodimer in activated B cells promoted BACH2 function by inducing gene expression of Bach2 and Pten, a negative regulator of AKT signaling. Elevated AKT activity in Bach2-deficient B cells resulted in IRF4 protein accumulation. Thus, BACH2 and IRF4 mutually modulate the activity of each other, and BACH2 inhibits PC differentiation by both the repression of PC genes and the restriction of IRF4 protein accumulation.
Intracanal microbiome profiles of two apical periodontitis cases in one patient: A comparison with saliva and plaque profiles. International-journal

Keiko Yamaki, Toru Tamahara, Jumpei Washio, Takuichi Sato, Ritsuko Shimizu, Satoru Yamada

Clinical and experimental dental research　10　(2)　e862　2024/04

DOI： 10.1002/cre2.862 　

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OBJECTIVES: To determine the characteristics of the endodontic microbiome. MATERIAL AND METHODS: Saliva, plaque, and infected root canal wall dentin of two teeth suffering from apical periodontitis were harvested from a 58-year-old man. Bacterial DNA was extracted from each sample, and 16S rRNA gene analysis targeting the V3-V4 region was conducted on the Illumina MiSeq platform using QIIME2. The functional potential of the microbiomes was inferred using PICRUSt2. RESULTS: The four microbiomes were different in structure and membership, yet the nine most abundant metabolic pathways were common among them. The two endodontic microbiomes were more anaerobic, rich in Firmicutes, and scarce in Actinobacteriota and Proteobacteria, compared with saliva and plaque microbiomes. Their profiles were dissimilar despite their clinical and radiographic similarities. CONCLUSIONS: The endodontic microbiomes were anaerobic, rich in Firmicutes, scarce in Actinobacteriota and Proteobacteria, and considerably varied within an individual.
The Significance of Bile in the Biliopancreatic Limb on Metabolic Improvement After Duodenal-Jejunal Bypass. International-journal

Tomomi Kawana, Hirofumi Imoto, Naoki Tanaka, Takahiro Tsuchiya, Akihiro Yamamura, Fumito Saijo, Masamitsu Maekawa, Toru Tamahara, Ritsuko Shimizu, Kei Nakagawa, Shinobu Ohnuma, Takashi Kamei, Michiaki Unno

Obesity surgery　2024/03/21

DOI： 10.1007/s11695-024-07176-7 　

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INTRODUCTION: Duodenal-jejunal bypass (DJB) is an experimental procedure in metabolic surgery that does not have a restrictive component. Changes in bile acid (BA) dynamics and intestinal microbiota are possibly related to metabolic improvement after DJB. Our previous studies involving obese diabetic rats showed the crucial role of the biliopancreatic limb (BPL) in metabolic improvement after DJB caused by BA reabsorption. We established a new DJB procedure to prevent bile from flowing into the BPL and aimed to elucidate the importance of bile in the BPL after DJB. METHODS: Otsuka Long-Evans Tokushima Fatty rats with diabetes were divided into three groups: two DJB groups and a sham group (n = 11). Duodenal-jejunal anastomosis was performed proximal to the papilla of Vater in the DJB group (n = 11). However, the DJB-D group (n = 11) underwent a new procedure with duodenal-jejunal anastomosis distal to the papilla of Vater for preventing bile flow into the BPL. RESULTS: Glucose metabolism improved and weight gain was suppressed in the DJB group, but not in the DJB-D and sham groups. Serum BA level and conjugated BA concentration were elevated in the DJB group. The gut microbiota was altered only in the DJB group; the abundance of Firmicutes and Bacteroidetes decreased and that of Actinobacteria increased. However, the DJB-D group exhibited no apparent change in the gut microbiota, similar to the sham group. CONCLUSION: BAs are essential in the BPL for metabolic improvement after DJB; they can improve the gut microbiota in these processes.
Progress report of the Tohoku Medical Megabank Community-Based Cohort Study: Study profile of the repeated center-based survey during second period in Miyagi Prefecture.

Atsushi Hozawa, Kumi Nakaya, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Junichi Sugawara, Eiichi Kodama, Yohei Hamanaka, Tomoko Kobayashi, Akira Uruno, Naho Tsuchiya, Takumi Hirata, Akira Narita, Akito Tsuboi, Toru Tamahara, Akihito Otsuki, Maki Goto, Makiko Taira, Ritsuko Shimizu, Kichiya Suzuki, Taku Obara, Masahiro Kikuya, Hirohito Metoki, Mami Ishikuro, Inaho Danjoh, Soichi Ogishima, Satoshi Nagaie, Naoko Minegishi, Masahiro Hiratsuka, Kazuki Kumada, Ichiko Nishijima, Takahiro Nobukuni, Yumi Yamaguchi-Kabata, Fuji Nagami, Shigeo Kure, Nobuo Fuse, Kengo Kinoshita, Yoko Izumi, Shinichi Kuriyama, Masayuki Yamamoto

Journal of epidemiology　2024/02/24

DOI： 10.2188/jea.JE20230241 　

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BACKGROUND: The purpose of this study was to report the basic profile of the Miyagi Prefecture part of a repeated center-based survey during the second period (2nd period survey) of the Tohoku Medical Megabank Community-Based Cohort Study (TMM CommCohort Study), as well as the participants' characteristics based on their participation type in the baseline survey. METHODS: The 2nd period survey, conducted from June 2017 to March 2021, included participants of the TMM CommCohort Study (May 2013 to March 2016). In addition to the questionnaire, blood, urine, and physiological function tests were performed during the 2nd period survey. There were three main ways of participation in the baseline survey: Type 1, Type 1 additional, or Type 2 survey. The 2nd period survey was conducted in the same manner as the Type 2 survey, which was based on the community support center (CSC). RESULTS: In Miyagi Prefecture, 29,383 (57.7%) of 50,967 participants participated in the 2nd period survey. The participation rate among individuals who had visited the CSC was approximately 80%. Although some factors differed depending on the participation type in the baseline survey, the 2nd period survey respondents in the Type 1 and Type 2 survey groups at baseline had similar traits. CONCLUSIONS: The 2nd period survey of the TMM CommCohort Study provided detailed follow-up information. Following up on the health conditions of the participants will clarify the long-term effects of disasters and contribute to personalized prevention.
Design and Progress of Child Health Assessments at Community Support Centers in the Birth and Three-Generation Cohort Study of the Tohoku Medical Megabank Project.

Tomoko Kobayashi, Mika Kobayashi, Naoko Minegishi, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Tomomi Onuma, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Akira Uruno, Junichi Sugawara, Kichiya Suzuki, Eiichi N Kodama, Yohei Hamanaka, Naho Tsuchiya, Mana Kogure, Naoki Nakaya, Makiko Taira, Mika Sakurai-Yageta, Toru Tamahara, Junko Kawashima, Maki Goto, Akihito Otsuki, Ritsuko Shimizu, Soichi Ogishima, Hiroaki Hashizume, Fuji Nagami, Tomohiro Nakamura, Atsushi Hozawa, Tadao Kobayashi, Nobuo Fuse, Shinichi Kuriyama, Shigeo Kure, Masayuki Yamamoto

The Tohoku journal of experimental medicine　259　(2)　93-105　2023/01/20

DOI： 10.1620/tjem.2022.J103 　

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The Tohoku Medical Megabank Project (TMM) has been conducting a birth and three-generation cohort study (the BirThree Cohort Study). We recruited 73,529 pregnant women and their family members for this cohort study, which included 23,143 newborns and 9,459 of their siblings. We designed and are in the process of conducting three-step health assessments for each newborn at approximately ages of 5, 10 and 16. These health assessments are administered at seven community support centers. Trained genome medical research coordinators conduct physical examinations of and collect biological specimens from each participant. The Sendai Children's Health Square has been established as the headquarters for these child health assessments and is utilized to accumulate knowledge that can facilitate the proper practice of child health assessments. We designed all the relevant health assessments facilities to allow parents and their children to participate in the health assessments concomitantly. Our centers serve as places where child participants and their parents can feel at ease as a result of the implementation of safety measures and child hospitality measures. The TMM BirThree Cohort Study is in the process of conducting strategically detailed health assessments and genome analysis, which can facilitate studies concerning the gene-environment interactions relevant to noncommunicable diseases. Through these operations, our study allows for a significant depth of data to be collected in terms of the number of biospecimens under study and the comprehensiveness of both basic and clinical data alongside relevant family information.
Phenotype Harmonization in the GLIDE2 Oral Health Genomics Consortium

K. Divaris, S. Haworth, J.R. Shaffer, V. Anttonen, J.D. Beck, Y. Furuichi, B. Holtfreter, D. Jönsson, T. Kocher, S.M. Levy, P.K.E. Magnusson, D.W. McNeil, K. Michaëlsson, K.E. North, U. Palotie, P.N. Papapanou, P.J. Pussinen, D. Porteous, K. Reis, A. Salminen, A.S. Schaefer, T. Sudo, Y.Q. Sun, A.L. Suominen, T. Tamahara, S.M. Weinberg, P. Lundberg, M.L. Marazita, I. Johansson

Journal of Dental Research　101　(11)　1408-1416　2022/10
Publisher: SAGE Publications
DOI： 10.1177/00220345221109775 　

ISSN： 0022-0345

eISSN： 1544-0591

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Genetic risk factors play important roles in the etiology of oral, dental, and craniofacial diseases. Identifying the relevant risk loci and understanding their molecular biology could highlight new prevention and management avenues. Our current understanding of oral health genomics suggests that dental caries and periodontitis are polygenic diseases, and very large sample sizes and informative phenotypic measures are required to discover signals and adequately map associations across the human genome. In this article, we introduce the second wave of the Gene-Lifestyle Interactions and Dental Endpoints consortium (GLIDE2) and discuss relevant data analytics challenges, opportunities, and applications. In this phase, the consortium comprises a diverse, multiethnic sample of over 700,000 participants from 21 studies contributing clinical data on dental caries experience and periodontitis. We outline the methodological challenges of combining data from heterogeneous populations, as well as the data reduction problem in resolving detailed clinical examination records into tractable phenotypes, and describe a strategy that addresses this. Specifically, we propose a 3-tiered phenotyping approach aimed at leveraging both the large sample size in the consortium and the detailed clinical information available in some studies, wherein binary, severity-encompassing, and “precision,” data-driven clinical traits are employed. As an illustration of the use of data-driven traits across multiple cohorts, we present an application of dental caries experience data harmonization in 8 participating studies ( N = 55,143) using previously developed permanent dentition tooth surface–level dental caries pattern traits. We demonstrate that these clinical patterns are transferable across multiple cohorts, have similar relative contributions within each study, and thus are prime targets for genetic interrogation in the expanded and diverse multiethnic sample of GLIDE2. We anticipate that results from GLIDE2 will decisively advance the knowledge base of mechanisms at play in oral, dental, and craniofacial health and disease and further catalyze international collaboration and data and resource sharing in genomics research.
Dental care using an oral appliance to support hematopoietic stem cell transplantation for NK/T cell lymphoma, nasal type, with palatal perforation.

Hanako Suenaga, Masahiro Iikubo, Toru Tamahara, Mina Dodo, Chris Peck, Takeyoshi Koseki, Hideo Harigae, Keiichi Sasaki

Journal of prosthodontic research　66　(2)　353-356　2021/07/15

DOI： 10.2186/jpr.JPR_D_20_00270 　

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PATIENT: A 33-year-old man diagnosed with extranodal natural killer cell/T-cell lymphoma, nasal type (ENKTCL-NT) inducing palatal perforation was referred to the perioperative oral care support center of Tohoku University Hospital for dental care to support cancer treatment including chemotherapy and hematopoietic stem cell transplantation (HSCT). Dental review during chemotherapy revealed mucositis suspected to be caused by mucosal trauma from altered jaw function (chewing and speech) due to palatal perforation. Although the patient was already in the cleanroom, an oral appliance as well as conservative care as recommended in oral management guidelines for HSCT were used to prevent worsening of oral mucositis at subsequent HSCT including High-dose chemotherapy and total body irradiation. After HSCT, a prosthodontist fitted a palatal obturator made by a dental technician and an oral surgeon reviewed the necrotic bone and removed the sequestra according to the changes in the palate. This approach involving a multidisciplinary team including a hematologist improved the impaired oral function and minimized oral complications . DISCUSSION: ENKTCL-NT and its treatment have a significant impact on patients' oral status. Hence, it is important to provide customized dental care based on previously endorsed guidelines according to the type of disease, treatment requirements, and oral and systemic status. CONCLUSIONS: This report indicated the importance of dental care with a customized plan before, during, and after HSCT for ENKTCL-NT with multidisciplinary supportive care for cancer patients to improve the impaired oral function and to minimize oral complications.
東北大学病院周術期口腔支援センター・予防歯科における紹介患者の動向

百々美奈, 岩永賢二郎, 玉原亨, 飯嶋若菜, 石河理紗, 猪狩真奈, 渡辺俊吾, 田中篤史, 加藤翼, 丹田奈緒子, 飯久保正弘, 小関健由

東北大学歯学雑誌　37/38/39　(2/1-2/1)　47-47　2020/06
Publisher: 東北大学歯学会
ISSN： 0287-3915
Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project. Peer-reviewed

Akito Tsuboi, Hiroyuki Matsui, Naru Shiraishi, Takahisa Murakami, Akihito Otsuki, Junko Kawashima, Tomomi Kiyama, Toru Tamahara, Maki Goto, Shihoko Koyama, Junichi Sugawara, Eiichi N Kodama, Hirohito Metoki, Atsushi Hozawa, Shinichi Kuriyama, Hiroaki Tomita, Masahiro Kikuya, Naoko Minegishi, Kichiya Suzuki, Seizo Koshiba, Gen Tamiya, Nobuo Fuse, Yuichi Aoki, Takako Takai-Igarashi, Soichi Ogishima, Tomohiro Nakamura, Mika Sakurai-Yageta, Fuji Nagami, Kengo Kinoshita, Shigeo Kure, Ritsuko Shimizu, Keiichi Sasaki, Masayuki Yamamoto

The Tohoku journal of experimental medicine　251　(2)　97-115　2020/06

DOI： 10.1620/tjem.251.97 　

ISSN： 0040-8727

eISSN： 1349-3329
Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project. International-journal

Sakae Saito, Yuichi Aoki, Toru Tamahara, Maki Goto, Hiroyuki Matsui, Junko Kawashima, Inaho Danjoh, Atsushi Hozawa, Shinichi Kuriyama, Yoichi Suzuki, Nobuo Fuse, Shigeo Kure, Riu Yamashita, Osamu Tanabe, Naoko Minegishi, Kengo Kinoshita, Akito Tsuboi, Ritsuko Shimizu, Masayuki Yamamoto

Frontiers in cellular and infection microbiology　10　604596-604596　2020

DOI： 10.3389/fcimb.2020.604596 　

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A baseline oral microbiome study of the Tohoku Medical Megabank Organization (TMM) was planned to characterize the profile of the oral microbiome in the Japanese population. The study also aimed to clarify risk factors for multifactorial diseases by integrated analysis of the oral microbiome and host genome/omics information. From 2013 to 2016, we collected three types of oral biospecimens, saliva, supragingival plaque, and tongue swab, from a total of 25,101 participants who had a dental examination in TMM. In this study, we used two independent cohorts; the Community-Based Cohort and Birth and Three-Generation Cohort as discovery and validation cohorts, respectively, and we selected participants examined by a single dentist. We found through the 16S ribosomal RNA gene sequencing analysis of 834 participants of the Community-Based Cohort Study that there are differences in the microbial composition and community structure between saliva and plaque. The species diversities in both saliva and plaque were increased in correlation with the severity of periodontal disease. These results were nicely reproduced in the analysis of 455 participants of the Birth and Three-Generation Cohort Study. In addition, strong positive and negative associations of microbial taxa in both plaque and saliva with periodontitis-associated biofilm formation were detected by co-occurrence network analysis. The classes Actinobacteria and Bacilli, including oral health-associated bacterial species, showed a positive correlation in saliva. These results revealed differences in microbial composition and community structure between saliva and plaque and a correlation between microbial species and the severity of periodontal disease. We expect that the large database of the oral microbiome in the TMM biobank will help in the discovery of novel targets for the treatment and prevention of oral diseases, as well as for the discovery of therapeutic and/or preventive targets of systemic diseases.
Design of the spacer for brachytherapy using 198Au grain for carcinoma of the tongue as a tool of perioperative oral management. Peer-reviewed

Hanako Suenaga, Toru Tamahara, Mina Dodo, Toshimitsu Murakami, Satoshi Sasaki, Kengo Ito, Keiichi Jingu, Takeyoshi Koseki, Keiichi Sasaki

Journal of prosthodontic research　62　(4)　518-521　2018/10

DOI： 10.1016/j.jpor.2018.07.002 　

ISSN： 1883-1958

eISSN： 2212-4632
The mTOR-Bach2 Cascade Controls Cell Cycle and Class Switch Recombination during B Cell Differentiation. International-journal Peer-reviewed

Toru Tamahara, Kyoko Ochiai, Akihiko Muto, Yukinari Kato, Nicolas Sax, Mitsuyo Matsumoto, Takeyoshi Koseki, Kazuhiko Igarashi

Molecular and cellular biology　37　(24)　2017/12/15

DOI： 10.1128/MCB.00418-17 　

ISSN： 0270-7306

eISSN： 1098-5549
[Extensive analysis of protein phosphorylation: An example of transcription factor Bach2].

Hiroki Shima, Ryo Ando, Toru Tamahara, Kazuhiko Igarashi

Seikagaku. The Journal of Japanese Biochemical Society　88　(1)　31-5　2016/02
Publisher:
ISSN： 0037-1017
The Transcription Factor Bach2 Is Phosphorylated at Multiple Sites in Murine B Cells but a Single Site Prevents Its Nuclear Localization. International-journal Peer-reviewed

Ryo Ando, Hiroki Shima, Toru Tamahara, Yoshihiro Sato, Miki Watanabe-Matsui, Hiroki Kato, Nicolas Sax, Hozumi Motohashi, Keiko Taguchi, Masayuki Yamamoto, Masaki Nio, Tatsuya Maeda, Kyoko Ochiai, Akihiko Muto, Kazuhiko Igarashi

The Journal of biological chemistry　291　(4)　1826-1840　2016/01/22

DOI： 10.1074/jbc.M115.661702 　

ISSN： 0021-9258

eISSN： 1083-351X
Measuring Flow Rates of Saliva for Accurate Diagnosis of Xerostomia Peer-reviewed

Eiko Yoshida, Jun Suzuki, Emi Ito, Ryoichi Hosokawa, Naoko Tanda, Toru Tamahara, Jun Harako, Katuhiko Taura, Takeyosuhi Koseki

Interface Oral Health Science 2011　223-225　2012
Publisher: Springer Japan
DOI： 10.1007/978-4-431-54070-0_63 　
Collaboration of Medical and Dental Facilities Promotes Oral Health Care in Hospitals Peer-reviewed

Jun Harako, Toru Tamahara, Ryoichi Hosokawa, Kazunori Kimura, Moritoshi Komagata, Koji Hanaoka, Seiichi Aonuma, Fusako Okuya, Kaoru Itagaki, Yukiko Akai, Kazuhiko Tamura, Hidetoshi Sonobe, Takeyoshi Koseki

Interface Oral Health Science 2011　297-299　2012
Publisher: Springer Japan
DOI： 10.1007/978-4-431-54070-0_88 　
Promotion of Professional Oral Care for Hospitalized and Home-Care Patients Peer-reviewed

Toru Tamahara, Jun Harako, Ryoichi Hosokawa, Kazunori Kimura, Moritoshi Komagata, Koji Hanaoka, Seiichi Aonuma, Fusako Okuya, Kaoru Itagaki, Yukiko Akai, Kazuhiko Tamura, Hidetoshi Sonobe, Takeyoshi Koseki

Interface Oral Health Science 2011　309-311　2012
Publisher: Springer Japan
DOI： 10.1007/978-4-431-54070-0_92

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Misc. 58

消化器疾患における腸内細菌叢の解析;病態解明と診療展開食道胃接合部癌発育伸展におけるdysbiosis・腸管粘膜バリア傷害の役割

須藤洸一郎, 宇野要, 玉原亨, 草野啓介, 田邊瑞樹, 菅野武, 浅野直喜, 小池智幸, 正宗淳

日本消化器病学会雑誌　121　(臨増総会)　A44-A44　2024/03
Publisher: (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
唾液タンパク組成と全身状態の関連性

渡辺俊吾, 岩永賢二郎, 百々美奈, 飯嶋若菜, 石河理紗, 玉原亨, 加藤翼, 織部令奈, 丹田奈緒子, 小関健由

口腔衛生学会雑誌　69　(増刊)　172-172　2019/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
術後性開口障害患者にかいくんを用いた開口訓練の効果について

田中篤史, 岩永賢二郎, 玉原亨, 百々美奈, 飯嶋若菜, 猪狩真奈, 渡辺俊吾, 加藤翼, 清信仁, 丹田奈緒子, 小関健由

日本歯科医療管理学会雑誌　53　(1)　75　2018/06/15

ISSN： 0387-5687
東北大学病院周術期口腔支援センターおよび予防歯科における診療の動向

田中篤史, 岩永賢二郎, 玉原亨, 百々美奈, 飯嶋若菜, 猪狩真奈, 渡辺俊吾, 加藤翼, 丹田奈緒子, 小関健由

みちのく歯学会雑誌　48　(1-2)　26-27　2017/12
Publisher: 東北地区歯科医学会
ISSN： 0385-0099
東北大学病院周術期口腔支援センターおよび予防歯科における診療の動向

田中篤史, 岩永賢二郎, 玉原亨, 百々美奈, 飯嶋若菜, 猪狩真奈, 渡辺俊吾, 加藤翼, 丹田奈緒子, 小関健由

みちのく歯学会雑誌　48　(1-2)　26-27　2017/12
Publisher: 東北地区歯科医学会
ISSN： 0385-0099
半夏瀉心湯による口腔粘膜炎抑制の新たな作用機序の報告

玉原亨, 丹田奈緒子, 佐久間陽子, 飯嶋若菜, 猪狩真奈, 百々美奈, 渡辺俊吾, 田中篤史, 波田野悠夏, 伊藤恵美, 高橋久美子, 細川亮一, 小関健由

口腔衛生学会雑誌　67　(4)　312-312　2017/10
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
東日本大震災後の東北大学病院口臭外来受診動態

丹田奈緒子, 玉原亨, 佐久間陽子, 飯嶋若菜, 猪狩真奈, 百々美奈, 渡辺俊吾, 田中篤史, 波多野悠夏, 伊藤恵美, 高橋久美子, 細川亮一, 小関健由

口腔衛生学会雑誌　67　(4)　312-312　2017/10
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
東北大学病院周術期口腔支援センターにおける初診患者の動向

百々美奈, 玉原亨, 飯嶋若菜, 猪狩真奈, 渡辺俊吾, 田中篤史, 加藤翼, 佐久間陽子, 丹田奈緒子, 山内健介, 半田慶介, 下田元, 小関健由, 細川亮一, 飯久保正弘

東北大学歯学雑誌　35/36　(2/1)　76-79　2017/06
Publisher: 東北大学歯学会
ISSN： 0287-3915
東北大学病院周術期口腔支援センターにおける初診患者の動向

百々美奈, 玉原亨, 飯嶋若菜, 猪狩真奈, 渡辺俊吾, 田中篤史, 加藤翼, 佐久間陽子, 丹田奈緒子, 山内健介, 半田慶介, 下田元, 小関健由, 小関健由, 小関健由, 細川亮一, 飯久保正弘

東北大学歯学雑誌　35/36　(2/1)　76-79　2017/06
Publisher: 東北大学歯学会
ISSN： 0287-3915
東北大学病院周術期口腔支援センターにおける診療の動向

百々美奈, 玉原亨, 渡辺俊吾, 田中篤史, 加藤翼, 畠山博之, 高橋志麻, 石川元洋, 高柳久与, 丹田奈緒子, 小関健由

口腔衛生学会雑誌　67　(増刊)　134-134　2017/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
地域住民の口腔保健の実施状況の10年間の経時変化

渡辺俊吾, 玉原亨, 百々美奈, 田中篤史, 加藤翼, 畠山博之, 高橋志麻, 石川元洋, 高柳久与, 丹田奈緒子, 小関健由

口腔衛生学会雑誌　67　(増刊)　135-135　2017/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
半夏瀉心湯は頭頸部化学放射線治療由来の口腔粘膜炎を抑制する

玉原亨, 細川亮一, 丹田奈緒子, 佐久間陽子, 飯嶋若菜, 百々美奈, 伊藤恵美, 高橋久美子, 小関健由

みちのく歯学会雑誌　47　(1-2)　81-82　2016/12
Publisher: 東北地区歯科医学会
ISSN： 0385-0099
頭頸部がんに対する化学放射線療法に伴う口腔粘膜炎に対する半夏瀉心湯の基礎研究と臨床的効果

細川亮一, 細川亮一, 玉原亨, 丹田奈緒子, 佐久間陽子, 飯嶋若菜, 百々美奈, 渡辺俊介, 伊藤恵美, 小関健由

和漢医薬学会学術大会要旨集　33回　102-103　2016/08
Publisher: (一社)和漢医薬学会
The role of dental team in perioperative management of oral function

細川亮一, 細川亮一, 玉原亨, 小関健由

Japanese Journal of Maxillo Facial Implants　15　(2)　71-76　2016/08
Publisher: (公社)日本顎顔面インプラント学会
ISSN： 1347-894X
病院における多職種連携による口腔のケアと管理の推進について

玉原亨, 細川亮一, 細川亮一, 細川亮一, 丹田奈緒子, 末永華子, 佐久間陽子, 管崎将樹, 飯嶋若菜, 百々美奈, 加藤翼, 渡辺俊吾, 伊藤恵美, 高橋久美子, 小関健由, 小関健由

東北大学歯学雑誌　34/35　(2/1)　13-26　2016/06
Publisher: 東北大学歯学会
ISSN： 0287-3915
東日本大震災前後の歯科医師の社会活動の取り組みについて

杉山美幸, 百々美奈, 加藤翼, 玉原亨, 飯島若菜, 末永華子, 菅崎将樹, 佐久間陽子, 丹田奈緒子, 伊藤恵美, 高橋久美子, 坪井明人, 土谷昌広, 細川亮一, 小関健由

口腔衛生学会雑誌　66　(3)　345-346　2016/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
東北大学病院予防歯科におけるBRONJ患者の動向

加藤翼, 細川亮一, 丹田奈緒子, 末永華子, 菅崎将樹, 佐久間陽子, 飯嶋若菜, 玉原亨, 百々美奈, 福井玲子, 山崎佐千子, 笠原千秋, 伊藤恵美, 高橋久美子, 手代木史枝, 馬目麻衣, 小関健由

口腔衛生学会雑誌　66　(3)　345-345　2016/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
エコチル追加調査による妊娠中の夫婦の口腔保健状況について

小関健由, 石川元洋, 玉原亨, 百々美奈, 加藤翼, 高橋久美子, 細川亮一, 丹田奈緒子, 末永華子, 飯島若菜, 菅崎将樹, 佐久間陽子, 伊藤恵美, 有馬隆博

宮城県公衆衛生学会会誌　(48)　12-12　2016/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
Debriefs and advices of the dentists who experienced the post-quake reconstruction from the Great East Japan Earthquake

杉山美幸, 玉原亨, 百々美奈, 加藤翼, 渡辺俊吾, 伊藤恵美, 土谷昌広, 坪井明人, 小関健由

感性福祉研究所年報　(17)　261-269　2016/03
Publisher: 東北福祉大学感性福祉研究所
ISSN： 1344-9966
ビッグデータから読み解く生命現象単一タンパク質の徹底的リン酸化解析と機能特定:転写因子Bach2を例に

島弘季, 安藤亮, 玉原亨, 五十嵐和彦

生化学　88　(1)　31-35　2016/02
Publisher: (公社)日本生化学会
DOI： 10.14952/SEIKAGAKU.2016.880031 　

ISSN： 0037-1017
「赤ちゃんとママのむし歯予防教室」の歯科保健学習効果について宮城県妊娠中からの歯科保健モデル事業から

根本充康, 細谷仁憲, 山本壽一, 新沼康弘, 鈴木宏明, 戸田愼治, 佐藤文彦, 佐々木隆二, 森拓也, 細川亮一, 丹田奈緒子, 末永華子, 菅崎将樹, 佐久間陽子, 飯島若菜, 菊地瑞穂, 玉原亨, 百々美奈, 加藤翼, 伊藤恵美, 高橋久美子, 戸田康子, 小関健由

みちのく歯学会雑誌　46　(1-2)　60-61　2015/12
Publisher: 東北地区歯科医学会
ISSN： 0385-0099
1歳6ヵ月児の母親の育児時の歯科保健意識の変化とう蝕発生との関連

戸田康子, 玉原亨, 伊藤恵美, 高橋久美子, 手代木史枝, 菅崎将樹, 佐久間陽子, 百々美奈, 加藤翼, 末永華子, 丹田奈緒子, 細川亮一, 小関健由

口腔衛生学会雑誌　65　(2)　204-204　2015/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
東日本大震災被災地の震災後の学校歯科保健の動向について

手代木史枝, 伊藤恵美, 戸田康子, 高橋久美子, 菅崎将樹, 佐久間陽子, 玉原亨, 百々美奈, 加藤翼, 末永華子, 丹田奈緒子, 細川亮一, 小関健由

口腔衛生学会雑誌　65　(2)　258-258　2015/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
東北大学病院における緩和医療に関する学生ならびに歯科医師に対する意識調査

細川亮一, 伊藤恵美, 手代木史枝, 丹田奈緒子, 菅崎将樹, 末永華子, 百々美奈, 佐久間陽子, 加藤翼, 玉原亨, 小関健由

口腔衛生学会雑誌　65　(2)　240-240　2015/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
1歳6か月児の母親の育児時の歯科保健意識の変化とう蝕発生との関連

戸田康子, 玉原亨, 伊藤恵美, 高橋久美子, 手代木史枝, 菅崎将樹, 佐久間陽子, 百々美奈, 加藤翼, 末永華子, 丹田奈緒子, 細川亮一, 小関健由

口腔衛生学会雑誌　65　(2)　204-204　2015/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
1歳6ヵ月児のう蝕発生に関与する妊娠中からの母親の意識と行動妊娠中からの歯科保健モデル事業報告から(1)

根本充康, 細谷仁憲, 山本壽一, 新沼康弘, 鈴木宏明, 戸田愼治, 佐藤文彦, 佐々木隆二, 細川亮一, 丹田奈緒子, 末永華子, 菅崎将樹, 佐久間陽子, 飯島若菜, 菊池瑞穂, 玉原亨, 百々美奈, 加藤翼, 伊藤恵美, 高橋久美子, 手代木史枝, 戸田康子, 小関健由

口腔衛生学会雑誌　65　(1)　58-59　2015/01
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
妊娠時と1歳6ヵ月児の育児時の母親の歯科保健に関する意識と行動の変化妊娠中からの歯科保健モデル事業報告から(2)

戸田康子, 細川亮一, 丹田奈緒子, 末永華子, 菅崎将樹, 佐久間陽子, 飯島若菜, 菊池瑞穂, 玉原亨, 百々美奈, 加藤翼, 伊藤恵美, 高橋久美子, 手代木史枝, 細谷仁憲, 山本壽一, 新沼康弘, 鈴木宏明, 戸田愼治, 佐藤文彦, 佐々木隆二, 根本充康, 小関健由

口腔衛生学会雑誌　65　(1)　59-59　2015/01
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
開口障害と多発性う蝕と放射線性顎骨壊死の重篤な晩期有害事象

原美里, 笠原千秋, 山崎佐千子, 福井玲子, 山田桂子, 手代木史枝, 高橋久美子, 伊藤恵美, 細川亮一, 丹田奈緒子, 末永華子, 菅崎将樹, 佐久間陽子, 飯島若菜, 菊池瑞穂, 玉原亨, 百々美奈, 加藤翼, 小関健由

口腔衛生学会雑誌　65　(1)　59-60　2015/01
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
農業地帯住民の歯科保健に関する意識調査について

百々美奈, 高橋文一, 木村俊春, 山崎達見, 庄司達雄, 野田清一, 伏見行則, 白石信也, 近江浩昭, 曽根憲一, 虻江勝, 久保圭, 渋谷芳和, 玉原亨, 小野瑞穂, 加藤翼, 細川亮一, 丹田奈緒子, 吉田英子, 伊藤恵美, 小関健由

口腔衛生学会雑誌　65　(1)　55-56　2015/01
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
東北大学病院におけるがん治療と歯科処置

小野瑞穂, 玉原亨, 百々美奈, 加藤翼, 福井玲子, 原美里, 山崎佐千子, 鈴木寿子, 細川亮一, 丹田奈緒子, 吉田英子, 末永華子, 飯嶋若菜, 伊藤恵美, 小関健由

口腔衛生学会雑誌　65　(1)　54-54　2015/01
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
妊娠時と1歳6か月児の育児時の母親の歯科保健に関する意識と行動の変化―妊娠中からの歯科保健モデル事業報告から(2)―

戸田康子, 細川亮一, 丹田奈緒子, 末永華子, 菅崎将樹, 佐久間陽子, 飯島若菜, 菊池瑞穂, 玉原亨, 百々美奈, 加藤翼, 伊藤恵美, 高橋久美子, 手代木史枝, 細谷仁憲, 山本壽一, 新沼康弘, 鈴木宏明, 戸田愼治, 佐藤文彦, 佐々木隆二, 根本充康, 小関健由

口腔衛生学会雑誌　65　(1)　59-59　2015/01
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
「赤ちゃんとママのむし歯予防」教室受講者の歯科保健に関する意識と行動―妊娠中からの歯科保健モデル事業報告から(3)―

菊池瑞穂, 細川亮一, 丹田奈緒子, 末永華子, 菅崎将樹, 佐久間陽子, 飯島若菜, 玉原亨, 百々美奈, 加藤翼, 伊藤恵美, 高橋久美子, 手代木史枝, 細谷仁憲, 山本壽一, 新沼康弘, 鈴木宏明, 戸田愼治, 佐藤文彦, 佐々木隆二, 根本充康, 小関健由

口腔衛生学会雑誌　65　(1)　59-59　2015/01
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
開口障害と多発性うしょくと放射線性顎骨壊死の重篤な晩期有害事象

原美里, 笠原千秋, 山崎佐千子, 福井玲子, 山田桂子, 手代木史枝, 高橋久美子, 伊藤恵美, 細川亮一, 丹田奈緒子, 末永華子, 菅崎将樹, 佐久間陽子, 飯島若菜, 菊池瑞穂, 玉原亨, 百々美奈, 加藤翼, 小関健由

口腔衛生学会雑誌　65　(1)　59-60　2015/01
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
1歳6カ月児のうしょく発生に関与する妊娠中からの母親の意識と行動―妊娠中からの歯科保健モデル事業報告から(1)―

根本充康, 細谷仁憲, 山本壽一, 新沼康弘, 鈴木宏明, 戸田愼治, 佐藤文彦, 佐々木隆二, 細川亮一, 丹田奈緒子, 末永華子, 菅崎将樹, 佐久間陽子, 飯島若菜, 菊池瑞穂, 玉原亨, 百々美奈, 加藤翼, 伊藤恵美, 高橋久美子, 手代木史枝, 戸田康子, 小関健由

口腔衛生学会雑誌　65　(1)　58-59　2015/01
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
子どもの歯科健康診断情報収録システムの開発とデータベース化の取り組み

加藤翼, 伊藤恵美, 玉原亨, 百々美奈, 小野瑞穂, 細川亮一, 丹田奈緒子, 吉田英子, 末永華子, 飯嶋若菜, 小関健由

口腔衛生学会雑誌　65　(1)　56-56　2015/01
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
頭頸部癌に対する開口訓練の効果の検証

吉田英子, 細川亮一, 丹田奈緒子, 末永華子, 菅崎将樹, 佐久間陽子, 飯嶋若菜, 菊池瑞穂, 玉原亨, 百々美奈, 加藤翼, 山崎佐千子, 原美里, 笠原千秋, 福井玲子, 伊藤恵美, 高橋久美子, 手代木史枝, 小関健由

みちのく歯学会雑誌　45　(1-2)　7-8　2014/12
Publisher: 東北地区歯科医学会
ISSN： 0385-0099
東北大学病院予防歯科におけるがん患者の周術期口腔支援

加藤翼, 細川亮一, 丹田奈緒子, 末永華子, 菅崎将樹, 佐久間陽子, 飯嶋若菜, 菊池瑞穂, 吉田英子, 玉原亨, 百々美奈, 山崎佐千子, 原美里, 笠原千秋, 福井玲子, 伊藤恵美, 高橋久美子, 手代木史枝, 小関健由

みちのく歯学会雑誌　45　(1-2)　74-75　2014/12
Publisher: 東北地区歯科医学会
ISSN： 0385-0099
妊産婦の出産前後における口腔保健の行動・意識調査

戸田康子, 伊藤恵美, 玉原亨, 加藤翼, 高橋久美子, 小関健由

日本歯科衛生学会雑誌　9　(1)　217-217　2014/08
Publisher: 日本歯科衛生学会
ISSN： 1884-5193
口の健康と認知に関する歯科からの話題―健康の基は食べることと話すこと,口の健康から全身の健康へ―

小関健由, 玉原亨, 百々美奈, 加藤翼

認知神経科学　16　(1)　1-8　2014/05
Publisher: 認知神経科学会
DOI： 10.11253/ninchishinkeikagaku.16.1 　

ISSN： 1344-4298

eISSN： 1884-510X
Topics of oral health and cognitive neuroscience from the viewpoint of dentistry : The basis of health is eating and talking : Oral health leads general health

小関健由, 玉原亨, 百々美奈

認知神経科学　16　(1)　1-8　2014/05
Publisher: 認知神経科学会
ISSN： 1344-4298
東北大学病院におけるがん支持療法としての口腔機能管理の取り組み

加藤翼, 細川亮一, 玉原亨, 吉田英子, 丹田奈緒子, 菅崎将樹, 末永華子, 百々美奈, 小野瑞穂, 伊藤恵美, 小関健由

口腔衛生学会雑誌　64　(2)　235-235　2014/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
転写因子Bach2はmTORによって制御される

玉原亨, 佐藤好宏, 落合恭子, 五十嵐和彦

日本分子生物学会年会プログラム・要旨集(Web)　37th　2P-0731 (WEB ONLY)　2014
Topics of oral health and cognitive neuroscience from the viewpoint of dentistry - The basis of health is eating and talking ; Oral health leads general health -

Koseki Takeyoshi, Tamahara Toru, Dohdoh Nami, Kato Tubasa

Japanese Journal of Cognitive Neuroscience　16　(1)　1-8　2014
Publisher: Japanese Society of Cognitive Neuroscience
DOI： 10.11253/ninchishinkeikagaku.16.1 　

ISSN： 1344-4298

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Healthy new born babies give the first cry and nurse themselves on mother's breasts at the beginning of their lives. Grown-up's mouth supports healthy lifestyle to enjoy eating, talking and laughing. When the last moment comes, leaving the last words to say good-bye helps their love ones and themselves rest in peace. Mouth works to take nutrition by eating meals, to reach to understand each other by talking, to express emotion ; delight, anger, sorrow and pleasure. The mouth supports their life from the birth until the end of their life as a human. According to Penfield's brain mapping, sense and move of mouth occupies 1/ 3 of whole brain field. From the discrimination distance between two points on the body surface, mouth is one of the most sensitive parts of the body such like hands. Recently, it is drawing attention that the oral health can be threatening to general health. Periodontitis, a gingival inflammation, leads to several health problems such as endocarditis, diabetes, premature delivery and a low birth-weight infant, by spreading oral bacteria or inflammatory cytokines through peripheral blood circulation. Erroneous swallowing of filthy saliva also develops aspiration pneumonia. Responding to these problems, it is recommended the establishment of team medical care including dentist and dental hygienist, the promotion of perioperative oral health management and oral health care of elderly. The distance between dental care and medical care are getting closer. This article introduces the importance of oral function by showing some references of oral health from the dentist's point of view.
妊産婦の出産前後における口腔保健の意識および行動の変化

伊藤恵美, 玉原亨, 吉田英子, 丹田奈緒子, 細川亮一, 大内康宏, 小関健由

日本歯科衛生学会雑誌　8　(1)　164-164　2013/08
Publisher: 日本歯科衛生学会
ISSN： 1884-5193
情報入力を省力化した歯科健診情報管理システムの構築

伊藤恵美, 玉原亨, 細川亮一, 吉田英子, 丹田奈緒子, 小島健, 斉藤純一, 小関健由

口腔衛生学会雑誌　63　(4)　362-363　2013/07
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
脱水素酵素濃度により歯周疾患スクリーニングの年齢別成績

平田正嗣, 玉原亨, 吉田英子, 梁川誠郎, 大山治, 山崎尚哉, 小菅玲, 大内康弘, 村上正博, 郷家茂樹, 木村一則, 高野友幸, 田鎖利明, 村上廣一, 馬場智彦, 細川亮一, 丹田奈緒子, 伊藤恵美, 小関健由, 長田純一

口腔衛生学会雑誌　63　(4)　363-364　2013/07
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
東北大学病院における周術期口腔機能管理

吉田英子, 玉原亨, 細川亮一, 丹田奈緒子, 小島健, 福井玲子, 佐藤由美子, 高橋美里, 小野ゆかり, 伊藤恵美, 小関健由

口腔衛生学会雑誌　63　(4)　364-364　2013/07
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
P-72 東北大学病院における口腔ケアの現状と症例(ポスター)

吉田英子, 玉原亨, 細川亮一, 丹田奈緒子, 伊藤恵美, 佐藤由美子, 小関健由

口腔衛生学会雑誌　63　(2)　203-203　2013/04/30
Publisher: 有限責任中間法人日本口腔衛生学会
ISSN： 0023-2831
P-74 歯科衛生士と看護師の協働の推進に関する質問紙調査(ポスター)

吉田志麻, 玉原亨, 細川亮一, 丹田奈緒子, 吉田英子, 伊藤恵美, 小関健由

口腔衛生学会雑誌　63　(2)　204-204　2013/04/30
Publisher: 有限責任中間法人日本口腔衛生学会
ISSN： 0023-2831
東北大学病院における口腔ケアの現状と症例

吉田英子, 玉原亨, 細川亮一, 丹田奈緒子, 伊藤恵美, 佐藤由美子, 小関健由

口腔衛生学会雑誌　63　(2)　203-203　2013/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
歯科衛生士と看護師の協働の推進に関する質問紙調査

吉田志麻, 玉原亨, 細川亮一, 丹田奈緒子, 吉田英子, 伊藤恵美, 小関健由

口腔衛生学会雑誌　63　(2)　204-204　2013/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
刺激唾液分泌量と口腔内健康指標との関連

吉田英子, 細川亮一, 丹田奈緒子, 伊藤恵美, 鈴木淳, 玉原亨, 小島健, 田浦勝彦, 小関健由

東北大学歯学雑誌　31　(2)　71-78　2012/12
Publisher: 東北大学歯学会
ISSN： 0287-3915
全身状態と口腔内因子の刺激唾液流出量との関連について

吉田英子, 玉原亨, 細川亮一, 伊藤恵美, 丹田奈緒子, 斎藤恵一, 田浦勝彦, 小関健由

口腔衛生学会雑誌　62　(2)　228-228　2012/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
東北大学病院における病棟患者における口腔ケアの臨床的検討

玉原亨, 細川亮一, 伊藤恵美, 吉田英子, 丹田奈緒子, 小関健由

口腔衛生学会雑誌　62　(2)　213-213　2012/04
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
若手研究者が踏み出した健康社会への一歩日韓のフロリデーション教育への取り組みの違い

玉原亨

口腔衛生学会雑誌　61　(4)　398-398　2011/08
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
東北6県における集団フッ化物洗口の実態 2010

田浦勝彦, 鍛治山徹, 五十嵐雄一, 田村光平, 佐藤勤一, 斎藤愼一, 栃内圭子, 黒田雅行, 田口千恵子, 木本一成, 境脩, 相田潤, 玉原亨, 原子惇, 鈴木淳, 細川亮一, 小関健由

みちのく歯学会雑誌　41　(1-2)　71-72　2010/12
Publisher: 東北地区歯科医学会
ISSN： 0385-0099
モンテカルロ法を用いた一日あたりの食事からのフッ化物摂取量の推計

玉原亨, 若栗真太郎, 相田潤, 小坂健

口腔衛生学会雑誌　60　(4)　381-381　2010/08
Publisher: (一社)日本口腔衛生学会
ISSN： 0023-2831
標準的検診法と精度管理や医療経済的効果に関する研究標準的検診法と精度管理や医療経済効果に関する研究

小坂健, 相田潤, 玉原亨

標準的検診法と精度管理や医療経済的効果に関する研究平成20年度総括研究報告書　39-41　2009

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Presentations 2

Hangeshashinto prevents oral mucositis under chemotherapy and radiotherapy to head and neck cancer International-presentation

Toru Tamahara

The Multinational Association of Supportive Care in Cancer (MASCC)　2016/06/23
A step toward a healthy society initiated by young researchers Invited

Toru Tamahara

Japanese society for dental health　2011/10/09

Industrial Property Rights 2

バンコマイシン耐性腸球菌の感染症を予防又は治療するための医薬及び腸内細菌叢のα-多様性向上剤

▲高▼山真, 鈴木聡子, 菊地章子, 有田龍太郎, 石井正, 青木裕一, 玉原亨, 清水律子

Property Type: Patent
抗リン酸化Bach2抗体及び抗腫瘍免疫活性化剤のスクリーニング方法

五十嵐和彦, 武藤哲彦, 落合恭子, 島弘季, 安藤亮, 佐藤好宏, 玉原亨, 佐藤勇樹

Property Type: Patent

Research Projects 7

Development of Innovative Oral Cancer Prediction Model Targeting Oral Bacterial Flora

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2024/04/01 - 2027/03/31
Understanding Odontogenic Focal Infection and New Approach in Oral Management Based on Integrated Analysis of Clinical, Imaging, and Bacterial Flora

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2024/04/01 - 2027/03/31
口腔細菌叢をターゲットとした新たな周産期合併症予測モデルの開発

玉原亨

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 若手研究

Institution: 東北大学

2021/04/01 - 2024/03/31

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本研究では周産期における口腔内細菌叢の変化に着目をし、周産期の口腔内細菌叢変化と周産期合併症の関連について探索をおこなう。この結果から、口腔内細菌叢をターゲットとした周産期合併症リスク予測モデルを構築し、比較的容易に介入できる口腔内環境の整備が周産期合併症のリスク軽減に寄与し得ることを明らかにする。具体的には、周産期の細菌叢の変動をUnifrac距離を用いて表現することで周産期合併症の原因となる口腔内細菌叢変動パターンを分離する。分離されたパターンおよびコホート調査における生理・生化学データを材料に機械学習をおこない、マルチモーダルベイジアンネットワークを構築することで、周産期合併症のリスク予想モデルを構築する。 269人の妊婦の唾液検体（807検体）の解析は既に終了しているため、本年度は歯垢検体（807検体）を用いて検体に含まれる細菌の16S rRNA配列の取得をおこなった。Miseqにより得られた16S rRNA配列から、QIIME2パイプラインに沿って各検体に含まれる細菌の組成を明らかにし、さらに検体間の細菌叢の変動をUnifrac距離を用いて算出した。また、周産期合併症に特有の歯垢細菌叢の時系列変化パターンの解析をおこなった。そして、唾液・歯垢それぞれの妊婦の周産期における口腔内細菌叢の変化をUnifrac距離を用いて表現し、周産期合併症の有無で重みを付けることによって時系列変化パターンを分離した。これら一連の分析から、唾液・歯垢ともに周産期特有のパターンを見出すことができ、さらに早産となる口腔細菌叢変化パターンがある可能性を示唆することができた。
Elucidation of the mechanism and strategies of the new preventive methods on aneurysm formation by oral bacteria Competitive

Tamahara Toru

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Early-Career Scientists

Institution: Tohoku University

2018/04 - 2021/03

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We have obtained 20 aneurysm samples and successfully cultured the bacteria in 13 cases. Bacterial DNA was extracted from the colonies that appeared, and the full length 16S rRNA region was amplified, finally the bacteria was identified by DNA sequencing. As a result, pathogenic bacteria of periodontal disease was not detected in aortic aneurysms and other aortic diseases, while staphylococcus and Propionibacterium acnes, which are indigenous bacteria of the body surface and oral cavity, was often detected. In addition, we established a system to amplify bacterial DNA in aneurysms by PCR, and showed that the detection ability differs between the culture method and the PCR method.
歯周病菌による動脈瘤形成機序の解明および新たな予防法の開発 Competitive

玉原亨

Offer Organization: 公益財団法人富徳会

System: 平成29年度研究者助成事業

2017/08 - 2018/03
The comprehensive survey for the risk factor of oral mucositis under the radiotherapy. Competitive

Hosokawa Ryoichi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2015/04 - 2018/03

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It is very important to prevent or reduce adverse events caused by the radiotherapy and chemotherapy for completing the treatment plan. Especially, the adverse events of head and neck cancer caused by radiotherapy are very severe. For instance, patients complain dry mouth and oral mucositis so on. Oral mucositis cause severe pain and reduce patient’s quality of life. It is very hard for patients to eat or talk due to the pain caused by oral mucositis. So it is requested to establish the methods inhibit oral mucositis during radiotherapy. In this study, we proposed the possibility to reduce the severity of oral mucositis using Hangeshasinto, which is one of traditional medicine in Japan in clinical study. Also we provide the mechanism how Hangeshasinto prevent oral mucositis by using cell culture experiments.
relation with between priodontal bacteria and aneurythms Competitive

Tamahara Toru

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Research Activity Start-up

Institution: Tohoku University

2015/08 - 2017/03

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We extracted DNA from the aneurysms samples after beads crush was performed to them. We obtained the DNA solution which tried the DNA amplification of the region that encoded 16rRNA using PCR with obtained DNA solution. As a result, We obtained the DNA contained with not only the bacterial DNA but also the aneurysms wall, we examined annealing temperature, and single band was detected in 55.7 degrees Celsius in 30 times for an amplification cycle when we set it and, furthermore, determined what could completely remove the gram-positive and negative bacteria which lived in what we washed with hypochlorous acid with aneurysms sample before the culture from aneurysms wall to be aneurysmal, and to remove bacterial DNA in the blood which attached.

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