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Yukio Katori

Section

Graduate School of Medicine

Job title

Professor

Degree

博士（医学）（東北大学）

researchmap

https://researchmap.jp/nao1224

J-GLOBAL ID

200901006817215218

e-Rad No.

20261620

Research History 16

2023/04 - Present

東北大学病院　副院長（診療、医療安全、コンプライアンス担当）
2022/10 - Present

東北大学大学院医学系研究科難聴地域医療学寄付講座　教授（兼任）
2013/11 - Present

Tohoku University　Graduate School of Medicine
2009/01 - 2013/10

仙台市立病院　耳鼻いんこう科　部長
2008/08 - 2009/01

東北大学病院　耳鼻咽喉・頭頸部外科　准教授
2006/04 - 2008/07

東北大学病院　耳鼻咽喉・頭頸部外科　講師
2003/04 - 2006/03

東北大学病院　耳鼻咽喉・頭頸部外科　助手
2001/07 - 2003/03

岩手県立宮古病院　耳鼻咽喉科　科長
1999/11 - 2001/06

東北大学医学部附属病院　耳鼻咽喉科　助手
1998/04 - 1999/10

東北公済病院　耳鼻咽喉科　第二科長
1996/10 - 1998/03

山形市立病院済生館　耳鼻咽喉科　科長
1994/10 - 1996/09

Keele University, UK　Department of Communication and Neuroscience　Visiting Research Fellow
1994/04 - 1996/09

東北大学医学部附属病院　耳鼻咽喉科　助手
1989/04 - 1990/03

東北労災病院　耳鼻咽喉科　研修医
1988/10 - 1989/03

東北公済病院　耳鼻咽喉科　研修医
1988/04 - 1988/09

東北大学医学部附属病院　耳鼻咽喉科　医員（研修医）

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Education 3

Yamagata University

1991/06 - 1994/03
Tohoku University　Graduate School, Division of Medicine

1990/04 - 1994/03
Tohoku University　Faculty of Medicine

1982/04 - 1988/03

Committee Memberships 23

日本頭頸部外科学会　理事

2022/11 - Present
日本気管食道科学会　理事長

2022/11 - Present
宮城県医師会　副会長

2020/07 - Present
日本嚥下医学会　副理事長

2020/05 - Present
日本摂食嚥下リハビリテーション学会　理事

2019/09 - Present
耳鼻咽喉科臨床学会　常任運営委員

2018/06 - Present
言語聴覚士国家試験試験委員

2017/04 - Present
日本音声言語医学会　理事

2016/09 - Present
日本耳鼻咽喉科頭頸部外科学会　代議員

2016/06 - Present
日本喉頭科学会　理事

2016/03 - Present
日本耳鼻咽喉科頭頸部外科学会　代議員

2015/01 - Present
日本気管食道科学会　理事

2014/11 - Present
日本嚥下医学会　理事

2014/02 - Present
日本臨床耳鼻咽喉科医会　理事

2022/06 - 2024/05
日本耳鼻咽喉科頭頸部外科学会　理事

2018/06 - 2024/05
日本耳科学会　代議員

2015/10 - 2023/09
日本小児耳鼻咽喉科学会　理事

2017/07 - 2023/06
日本音声言語医学会　理事長

2019/11 - 2022/11
日本医師会　国際保健検討委員会委員

2020/08 - 2022/06
日本口腔・咽頭科学会　理事

2015/09 - 2021/08
日本頭頸部外科学会　理事

2015/01 - 2021/03
日本耳鼻咽喉科学会　幹事

2014/06 - 2018/05
Health Insurance Claims Review & Reimbursement Services, Miyagi Branch　Judge

2010 - 2015

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Professional Memberships 15

JAPAN SOCIETY OF IMMUNOLOGY AND ALLERGOLOGY IN OTOLARYNGOLOGY

2021/04 - Present
THE JAPANESE RHINOLOGIC SOCIETY

2018/04 - Present
Dysphagia Research Society

2014/03 - Present
THE JAPAN SOCIETY OF LOGOPEDICS AND PHONIATRICS

2013/12 - Present
JAPAN AUDIOLOGICAL SOCIETY

2013/11 - Present
日本摂食嚥下リハビリテーション学会

2008/04 - Present
日本嚥下医学会

2006/04 - Present
JAPAN SOCIETY FOR PEDIATRIC OTORHINOLARYNGOLOGY

2006/04 - Present
THE JAPAN LARYNGOLOGICAL ASSOCIATION

2004/03 - Present
THE SOCIETY OF PRACTICAL OTOLARYNGOLOGY

1999/09 - Present
THE JAPAN BRONCHO-ESOPHAGOLOGICAL SOCIETY

1999/04 - Present
JAPAN SOCIETY OF STOMATO-PHARYNGOLOGY

1994/08 - Present
Association for Research in Otolaryngology

1993/01 - Present
JAPAN OTOLOGICAL SOCIETY

1991/04 - Present
Japanese Society of Otorhinolaryngology - Head and Neck Surgery

1988/05 - Present

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Research Interests 5

頭頸部外科学
音声言語
摂食嚥下
聴覚
耳鼻咽喉科学

Research Areas 1

Life sciences / Otorhinolaryngology /

Papers 326

Fatty acid binding protein type 7 deficiency preserves auditory function in noise-exposed mice. International-journal Peer-reviewed

Jun Suzuki, Tomotaka Hemmi, Masamitsu Maekawa, Masahiro Watanabe, Hitoshi Inada, Hiroyuki Ikushima, Tetsuya Oishi, Ryoukichi Ikeda, Yohei Honkura, Yoshiteru Kagawa, Tetsuaki Kawase, Nariyasu Mano, Yuji Owada, Noriko Osumi, Yukio Katori

Scientific reports　13　(1)　21494-21494　2023/12/06

DOI： 10.1038/s41598-023-48702-4 　

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Fatty acid-binding protein 7 (FABP7) is vital for uptake and trafficking of fatty acids in the nervous system. To investigate the involvement of FABP7 in noise-induced hearing loss (NIHL) pathogenesis, we used Fabp7 knockout (KO) mice generated via CRISPR/Cas9 in the C57BL/6 background. Initial auditory brainstem response (ABR) measurements were conducted at 9 weeks, followed by noise exposure at 10 weeks. Subsequent ABRs were performed 24 h later, with final measurements at 12 weeks. Inner ears were harvested 24 h after noise exposure for RNA sequencing and metabolic analyses. We found no significant differences in initial ABR measurements, but Fabp7 KO mice showed significantly lower thresholds in the final ABR measurements. Hair cell survival was also enhanced in Fabp7 KO mice. RNA sequencing revealed that genes associated with the electron transport chain were upregulated or less impaired in Fabp7 KO mice. Metabolomic analysis revealed various alterations, including decreased glutamate and aspartate in Fabp7 KO mice. In conclusion, FABP7 deficiency mitigates cochlear damage following noise exposure. This protective effect was supported by the changes in gene expression of the electron transport chain, and in several metabolites, including excitotoxic neurotransmitters. Our study highlights the potential therapeutic significance of targeting FABP7 in NIHL.
HDR syndrome, detected in the neonatal period by newborn hearing screening. International-journal Peer-reviewed

Shunsuke Takai, Mika Adachi, Hiyori Takahashi, Masayuki Shirakura, Yohei Honkura, Daisuke Yamauchi, Yukio Katori

Auris, nasus, larynx　2023/08/26

DOI： 10.1016/j.anl.2023.08.007 　

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Hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome is an autosomal dominant disorder. Because HDR syndrome is caused by haploinsufficiency in GATA3, it exhibits variation in the onset and progression of hearing loss. In previous reports, the automated auditory brainstem response (AABR) was considered insufficient to detect sensorineural hearing loss caused by HDR syndrome. We report a case of HDR syndrome whose congenital hearing loss was detected by newborn hearing screening (NHS) using AABR. In this case, HDR syndrome was suspected due to hearing loss, hypocalcemia, and her family history. Genetic testing confirmed the diagnosis of HDR syndrome at 5 months of age. Because the phenotype of hearing loss due to HDR syndrome is variable and includes progressive hearing loss, these cases may not be detected by the HNS. However, most of the previous reports were published before the NHS became common and given the frequency of hearing loss complications in HDR syndrome. We consider that there is a reasonable number of HDR syndrome cases with abnormalities on the NHS. We believe that the NHS may also be useful for early detection of hearing loss due to HDR syndrome.
Transient connection between the vestibular aqueduct and utricle: a study using sagittal sections of human embryonic heads. International-journal

Yohei Honkura, Yukio Katori, Ai Hirano-Kawamoto, Tetsuaki Kawase, Jose Francisco Rodríguez-Vázquez, Gen Murakami, Hiroshi Abe

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft　250　152113-152113　2023/06/08

DOI： 10.1016/j.aanat.2023.152113 　

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BACKGROUND: The aqeductus vestibuli (aqueduct) is believed to connect to the saccule in embryos and adults. However, in embryos, the saccule and utricle are known to communicate widely to provide a common endolymph space "atrium". METHODS: Using sagittal histological sections from five embryos (crown-rump length or CRL, 14-21mm), nine early fetuses (CRL 24-35mm) and 12 midterm and near-term fetuses (CRL 82-272mm), we revisited the development and growth of the human ear aqueduct. RESULTS: The atrium took on a thick tube-like appearance as an antero-inferior continuation of the aqueduct, but soon divided into multiple gulfs. Most of the gulfs corresponded to the ampullae of semicircular ducts, while one gulf at the antero-medio-inferior corner corresponded to the future saccule. Notably, in eight of the 14 embryos and early fetuses, the aqueduct ended at the utricle near the primitive ampulla of the anterior (superior) or posterior semicircular duct. Conversely, an embryo of CRL 21mm was the smallest specimen in which the aqueduct joined the gulf-like saccule. At midterm and near-term, the growing perilymph space separated the aqueduct from the utricle and appeared to push the aqueduct toward the saccule. A topographical change occurred between the embryonic superiorly located utricle and the inferiorly-located saccule to create the antero-posterior arrangement in adults. CONCLUSIONS: Consequently, the vestibular end of the aqueduct was most likely to migrate anteriorly from the utricle to the saccule at 6-8 weeks possibly due to differential growth of the endothelium. Previous reconstructions of the embryonic aqueduct might be biased by the adult morphology.
Examination of Factors Affecting the Likelihood of Whether Individuals Would Purchase Cartilage Conduction Hearing Aids. International-journal Peer-reviewed

Shunsuke Takai, Takeshi Sato, Yuya Miyakura, Mika Adachi, Yohei Honkura, Daisuke Yamauchi, Yukio Katori

Audiology research　13　(3)　347-356　2023/05/11

DOI： 10.3390/audiolres13030030 　

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Cartilage conduction hearing aids (CC-HAs) are a novel type of hearing aid relying on cartilage conduction, the so-called third auditory conduction pathway. However, CC-HAs have only recently entered routine clinical use, and therefore data on their usefulness are lacking. The purpose of this study was to examine the possibility of assessing whether individual patients would show good adaptation to CC-HAs. Thirty-three subjects (41 ears in total) underwent a free trial of CC-HAs. Age, disease category, and the pure-tone threshold of air and bone conduction, unaided field sound threshold, aided field sound threshold, and functional gain (FG) at 0.25, 0.5, 1, 2, and 4 kHz were compared between patients who subsequently purchased and did not purchase the CC-HAs. Overall, 65.9% of the subjects purchased CC-HAs after the trial. In comparison to non-purchasers, those who decided to purchase CC-HAs showed better pure tone hearing thresholds at high frequencies for both air conduction (2 and 4 kHz) and bone conduction (1, 2, and 4 kHz), as well as for aided thresholds in the sound field (1, 2, and 4 kHz) when using CC-HAs. Therefore, the high-frequency hearing thresholds of subjects trialing CC-HAs might be helpful for identifying those who are likely to benefit from them.
Relationship between age-related hearing loss and consumption of coffee and tea. Peer-reviewed

Gosuke Watarai, Jun Suzuki, Ikuko N Motoike, Miyuki Sakurai, Ryoukichi Ikeda, Tetsuaki Kawase, Kengo Kinoshita, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Fuse, Masayuki Yamamoto, Yukio Katori

Geriatrics & gerontology international　2023/05/03

DOI： 10.1111/ggi.14589 　
Possibility of additive effects by the presentation of visual information related to distractor sounds on the contra-sound effects of the N100m responses. International-journal Peer-reviewed

Shunsuke Takai, Akitake Kanno, Tetsuaki Kawase, Masayuki Shirakura, Jun Suzuki, Nobukatsu Nakasato, Ryuta Kawashima, Yukio Katori

Hearing research　434　108778-108778　2023/04/23

DOI： 10.1016/j.heares.2023.108778 　

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Auditory-evoked responses can be affected by different types of contralateral sounds or by attention modulation. The present study examined the additive effects of presenting visual information about contralateral sounds as distractions during dichotic listening tasks on the contralateral effects of N100m responses in the auditory-evoked cortex in 16 subjects (12 males and 4 females). In magnetoencephalography, a tone-burst of 500 ms duration at a frequency of 1000 Hz was played to the left ear at a level of 70 dB as a stimulus to elicit the N100m response, and a movie clip was used as a distractor stimulus under audio-only, visual-only, and audio-visual conditions. Subjects were instructed to pay attention to the left ear and press the response button each time they heard a tone-burst stimulus in their left ear. The results suggest that the presentation of visual information related to the contralateral sound, which worked as a distractor, significantly suppressed the amplitude of the N100m response compared with only the contralateral sound condition. In contrast, the presentation of visual information related to contralateral sound did not affect the latency of the N100m response. These results suggest that the integration of contralateral sounds and related movies may have resulted in a more perceptually loaded stimulus and reduced the intensity of attention to tone-bursts. Our findings suggest that selective attention and saliency mechanisms may have cross-modal effects on other modes of perception.
Effects of Ndufs4 Deletion on Hearing after Various Acoustic Exposures. Peer-reviewed

Tomotaka Hemmi, Jun Suzuki, Yoshiteru Kagawa, Yohei Honkura, Ryoukichi Ikeda, Ken Hashimoto, Chitose Suzuki, Tetsuaki Kawase, Takaaki Abe, Yuji Owada, Yukio Katori

The Tohoku journal of experimental medicine　2023/04/20

DOI： 10.1620/tjem.2023.J031 　
Activation of the NRF2 pathway in Keap1-knockdown mice attenuates progression of age-related hearing loss. International-journal Peer-reviewed

Tetsuya Oishi, Daisuke Matsumaru, Nao Ota, Hiroshi Kitamura, Tianxiang Zhang, Yohei Honkura, Yukio Katori, Hozumi Motohashi

NPJ aging and mechanisms of disease　6　(1)　14-14　2020/12/14

DOI： 10.1038/s41514-020-00053-4 　

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Age-related hearing loss (AHL) is a progressive sensorineural hearing loss in elderly people. Although no prevention or treatments have been established for AHL, recent studies have demonstrated that oxidative stress is closely related to pathogenesis of AHL, suggesting that suppression of oxidative stress leads to inhibition of AHL progression. NRF2 is a master transcription factor that regulates various antioxidant proteins and cytoprotection factors. To examine whether NRF2 pathway activation prevents AHL, we used Keap1-knockdown (Keap1FA/FA) mice, in which KEAP1, a negative regulator of NRF2, is decreased, resulting in the elevation of NRF2 activity. We compared 12-month-old Keap1FA/FA mice with age-matched wild-type (WT) mice in the same breeding colony. In the Keap1FA/FA mice, the expression levels of multiple NRF2 target genes were verified to be significantly higher than the expression levels of these genes in the WT mice. Histological analysis showed that cochlear degeneration at the apical and middle turns was ameliorated in the Keap1FA/FA mice. Auditory brainstem response (ABR) thresholds in the Keap1FA/FA mice were significantly lower than those in the WT mice, in particular at low-mid frequencies. Immunohistochemical detection of oxidative stress markers suggested that oxidative stress accumulation was attenuated in the Keap1FA/FA cochlea. Thus, we concluded that NRF2 pathway activation protects the cochlea from oxidative damage during aging, in particular at the apical and middle turns. KEAP1-inhibiting drugs and phytochemicals are expected to be effective in the prevention of AHL.
Clinical utility of apparent diffusion coefficient and diffusion-weighted magnetic resonance imaging for resectability assessment of head and neck tumors with skull base invasion. International-journal Peer-reviewed

Takenori Ogawa, Ikuho Kojima, Shun Wakamori, Takuya Yoshida, Takaki Murata, Maya Sakamoto, Akira Ohkoshi, Ayako Nakanome, Hidenori Endo, Toshiki Endo, Hajime Usubuchi, Yukio Katori

Head & neck　42　(10)　2896-2904　2020/10
Publisher: Wiley
DOI： 10.1002/hed.26336 　

ISSN： 1043-3074

eISSN： 1097-0347

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BACKGROUND: The usefulness of apparent diffusion coefficient (ADC) and diffusion-weighted magnetic resonance imaging (DWI) in the detection of malignant tumors has been reported. The purpose of this study is to clarify the role of ADC and DWI for diagnosis of skull base tumors. METHODS: A total of 27 patients with head and neck tumors with skull base invasions undergoing skull base surgery were enrolled in this study. Pathological findings of dural invasion and bone invasion were compared with the diagnostic imaging. RESULTS: Advanced magnetic resonance imaging techniques revealed that ADC values in regions of pathological bone and dural invasions were significantly lower than in regions of no invasion. The area under the curve of ADC in bone invasions and dural invasions were 0.957 and 0.894, respectively. CONCLUSIONS: Our findings indicate that ADC and DWI are useful tools for the diagnosis of head and neck tumors with skull base invasion.
Questionnaire survey on nurses and speech therapists regarding dysphagia rehabilitation in Japan. International-journal Peer-reviewed

Kengo Kato, Ryoukichi Ikeda, Jun Suzuki, Ai Hirano-Kawamoto, Yayoi Kamakura, Masako Fujiu-Kurachi, Masamitsu Hyodo, Shin-Ichi Izumi, Shigeto Koyama, Keiichi Sasaki, Junko Nakajima, Takahiro Karaho, Yurika Kimura, Yoshihiko Kumai, Yasushi Fujimoto, Takaharu Nito, Yoshitaka Oku, Hajime Kurosawa, Shinichi Kuriyama, Yukio Katori

Auris, nasus, larynx　48　(2)　241-247　2020/08/25

DOI： 10.1016/j.anl.2020.08.004 　

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OBJECTIVE: Current interventions of dysphagia are not generalizable, and treatments are commonly used in combination. We conducted a questionnaire survey on nurses and speech therapists regarding dysphagia rehabilitation to understand the current situation in Japan. METHODS: The questionnaire was sent to 616 certified nurses in dysphasia nursing and 254 certified speech-language-hearing therapists for dysphagia. Based on "Summaries of training methods in 2014" by JSDR, 24 local indirect exercises, 11 general indirect exercises, and 13 direct exercises were selected. The Likert scale "How do you feel about each method" was used as follows: A; Frequency, B; Ease, C; Adherence, D; Effectiveness (1-5))?". RESULTS: Two hundred fifty (40%) nurses and 145 (57%) speech-language-hearing therapists (ST) responded to the questionnaire. The direct exercise was associated with a significantly high score in every question. In indirect exercises, "Cervical range of motion exercise," "Orofacial myofunctional exercise," "Lip closure exercise." "Ice massage of pharynx" and "Huffing" were used relatively frequently. "Balloon dilatation therapy" and "Tube exercise" was associated with a relatively high discrepancy for two questions. Frequency" and the sum of "Ease," "Adherence," and "Effectiveness." was significantly correlated for local indirect exercises (r2 = 0.928, P < 0.01), general indirect exercises (r2 = 0.987, P < 0.01), and direct exercises (r2 = 0.996, P < 0.01) (Fig. 5). CONCLUSION: This study examined the current situation of dysphagia rehabilitation in Japan. Our results aid to increase understanding and selection of rehabilitative treatments for dysphagia patients in Japan.
Simultaneous evaluation of symptoms, swallowing functions, and patient-reported swallowing difficulties and their correlations with ingestion status during definitive chemoradiotherapy for oropharyngeal and hypopharyngeal cancer. International-journal Peer-reviewed

Ryo Ishii, Kengo Kato, Akira Ohkoshi, Takeshi Sato, Ai Hirano, Takenori Ogawa, Yukio Katori

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer　29　(2)　955-964　2020/06/16

DOI： 10.1007/s00520-020-05570-2 　

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PURPOSE: To clarify the correlations among symptoms, swallowing functions, and ingestion status and to validate a method of swallowing evaluation during chemoradiotherapy (CRT) for head and neck cancer. METHODS: Oropharyngeal and hypopharyngeal cancer patients who were to receive definitive CRT as initial treatment were included in this prospective, single-center, observational study. The Functional Oral Intake Scale (FOIS) for ingestion status and grades of symptoms (dryness, dysgeusia, mucositis, and the analgesic ladder); the Yale Pharyngeal Residue Severity Rating Scale on fiberoptic endoscopic evaluation of swallowing (FEES) and the Penetration-Aspiration Scale (PAS) on videofluoroscopic (VF) evaluation for swallowing functions; and the 10-item Eating Assessment Tool (EAT-10) questionnaire were assessed at 5 time points unless the participant refused. The FEES and VF evaluation findings at each point were also compared. RESULTS: There were 38 participants. Dysgeusia, mucositis, and pain grade, as well as the FOIS score, were the worst at 70 Gy and then improved after treatment. The improvements of pharyngeal residue and the PAS after treatment were limited. The EAT-10 and the pain ladder were highly correlated with the FOIS changes at many time points. The VF evaluation rate dropped after 40 Gy, whereas the FEES rate remained high. There were good correlations between pharyngeal residue and the PAS at 0 Gy, 70 Gy, and 3 months. CONCLUSION: The EAT-10 and pain reflected the FOIS score changes well, while two swallowing evaluations did not. To avoid aspiration, VF evaluation may not be necessary during CRT because of high correlations with pharyngeal residue on FEES.
Development and growth of auricular cartilage and muscles: A study using human fetuses. International-journal Peer-reviewed

Yohei Honkura, Shogo Hayashi, Ji Hyun Kim, Gen Murakami, Hiroshi Abe, José Francisco Rodríguez-Vázquez, Yukio Katori

International journal of pediatric otorhinolaryngology　133　109973-109973　2020/06

DOI： 10.1016/j.ijporl.2020.109973 　

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OBJECTIVES: The auricle is a key target in pediatric plastic surgery and is considered to develop from a ring- or funnel-like arrangement of six hillocks in the embryo. However, there has been no report showing the morphologies of the auricular muscle and cartilage after midterm in humans. METHODS: We examined histological sections of 20 near-term human fetuses (29-40 weeks) and those from 7 midterm fetuses (15-16 weeks). RESULTS: At midterm, the auricular cartilage was a single wavy plate with the helicis major muscle (HMM). The superior and posterior auricular muscles (SAM, PAM) were inserted into the middle parts, and the anterior auricular muscle (AAM) was inserted into the lowest part of the cartilage plate, while the tragus and antitragus were not clearly identified. In near-term fetuses, the cartilage plate varied in size and shape between specimens. The scapha and antihelix were separated from the cartilage plate with major or minor involvement of the HMM from the initial mass along the helix. The SAM inserted to the crus helix or the developing scapha, while the insertion sites of the AAM and PAM into the helix were stable. The tragus-antitragus cartilages were well-developed and they sandwiched a deep notch of skin below the helix tail. The antitragicus muscle was more evident than the tragicus muscle. An unnamed muscle was evident along the external acoustic meatus. The other intrinsic muscles, including the transverse and oblique muscles, might develop from the HMM after birth. CONCLUSIONS: Development of the auricle was advanced after midterm. However, a single wavy plate-like cartilage was maintained until late-stage. Near term, the antihelix and scapha developed from the plate-like core of the auricle and the tragus and antitragus were added in the antero-inferior side of the cartilage plate. Establishment of muscle arrangements was markedly delayed compared to cartilage development. Altogether, the classical concept of an initial funnel-like arrangement of cartilage anlagen might have been biased by studies of adult morphology.
Switching of Sox9 expression during musculoskeletal system development. International-journal Peer-reviewed

Ryotaro Nagakura, Masahito Yamamoto, Juhee Jeong, Nobuyuki Hinata, Yukio Katori, Wei-Jen Chang, Shinichi Abe

Scientific reports　10　(1)　8425-8425　2020/05/21

DOI： 10.1038/s41598-020-65339-9 　

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The musculoskeletal system, which comprises muscles, tendons, and bones, is an efficient tissue complex that coordinates body movement and maintains structural stability. The process of its construction into a single functional and complex organization is unclear. SRY-box containing gene 9 (Sox9) is expressed initially in pluripotent cells and subsequently in ectodermal, endodermal, and mesodermal derivatives. This study investigated how Sox9 controls the development of each component of the musculoskeletal system. Sox9 was expressed in MTJ, tendon, and bone progenitor cells at E13 and in bone at E16. We detected Sox9 expression in muscle progenitor cells using double-transgenic mice and myoblastic cell lines. However, we found no Sox9 expression in developed muscle. A decrease in Sox9 expression in muscle-associated connective tissues, tendons, and bones led to hypoplasia of the cartilage and its attachment to tendons and muscle. These results showed that switching on Sox9 expression in each component (muscle, tendon, and bone) is essential for the development of the musculoskeletal system. Sox9 is expressed in not only tendon and bone progenitor cells but also muscle progenitor cells, and it controls musculoskeletal system development.
Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice. International-journal Peer-reviewed

Yohei Honkura, Jun Suzuki, Nobuyuki Sakayori, Hitoshi Inada, Tetsuaki Kawase, Yukio Katori, Noriko Osumi

BMC research notes　12　(1)　768-768　2019/11/26

DOI： 10.1186/s13104-019-4809-8 　

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OBJECTIVE: Dietary intervention is a practical prevention strategy for age-related hearing loss (AHL). Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) may be effective in prevention of AHL due to their anti-inflammatory and tissue-protective functions. Age-related changes in the hearing function of wild-type and Fat-1 transgenic mice derived from the C57BL/6N strain, which can convert omega-6 PUFAs to n-3 PUFAs and consequently produce enriched endogenous n-3 PUFAs, were investigated to test the efficacy of n-3 PUFAs for AHL prevention. RESULTS: At 2 months, the baseline auditory brainstem response (ABR) thresholds were the same in Fat-1 and wild-type mice at 8-16 kHz but were significantly higher in Fat-1 mice at 4 and 32 kHz. In contrast, the ABR thresholds of Fat-1 mice were significantly lower at 10 months. Moreover, the ABR thresholds of Fat-1 mice at low-middle frequencies were significantly lower at 13 months (12 kHz). Body weights were significantly reduced in Fat-1 mice at 13 months, but not at 2, 10, and 16-17 months. In conclusion, enriched endogenous n-3 PUFAs produced due to the expression of the Fat-1 transgene partially alleviated AHL in male C57BL/6N mice.
"Passenger gene" problem in transgenic C57BL/6 mice used in hearing research. International-journal Peer-reviewed

Jun Suzuki, Hitoshi Inada, Chul Han, Mi-Jung Kim, Ryuichi Kimura, Yusuke Takata, Yohei Honkura, Yuji Owada, Tetsuaki Kawase, Yukio Katori, Shinichi Someya, Noriko Osumi

Neuroscience research　158　6-15　2019/10/14

DOI： 10.1016/j.neures.2019.10.007 　

ISSN： 0168-0102

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Despite recent advances in genome engineering technologies, traditional transgenic mice generated on a mixed genetic background of C57BL/6 and 129/Sv mice remain widely used in age-related hearing loss (AHL) research, since C57BL/6 mice exhibit early onset and progression of AHL due to a mutation in cadherin 23-encoding gene (Cdh23753G>A). In these transgenic mice, backcrossing for more than 10 generations results in replacement of the donor background (129/Sv) with that of the recipient (C57BL/6), so that approximately 99.9% of genes are C57BL/6-derived and are considered congenic. However, the regions flanking the target gene may still be of 129/Sv origin, creating a so-called "passenger gene problem" where the normal 129/Sv-derived Cdh23753G allele can travel with the target gene. In this study, we investigated the role of fatty acid-binding protein 7 (Fabp7), which is important for cellular uptake and intracellular trafficking of fatty acids in the cochlea, using traditional Fabp7 knockout (KO) mice on the C57BL/6 background. We found that Fabp7 KO mice showed delayed AHL progression and milder cochlear degeneration. However, the genotype of the Cdh23 region flanking Fabp7 was still that of 129/Sv origin (Cdh23753GG). Our findings reveal the potential risk of contamination for traditional transgenic mice generated on the C57BL/6 background.
Humanized anti-CD271 monoclonal antibody exerts an anti-tumor effect by depleting cancer stem cells. Peer-reviewed

Morita S, Mochizuki M, Wada K, Shibuya R, Nakamura M, Yamaguchi K, Yamazaki T, Imai T, Asada Y, Matsuura K, Sugamura K, Katori Y, Satoh K, Tamai K

Cancer letters　461　144-152　2019/10

DOI： 10.1016/j.canlet.2019.07.011 　

ISSN： 0304-3835
Intratumoral delivery of an HPV vaccine elicits a broad anti-tumor immune response that translates into a potent anti-tumor effect in a preclinical murine HPV model. Peer-reviewed

Ishida E, Lee J, Campbell JS, Chakravarty PD, Katori Y, Ogawa T, Johnson L, Mukhopadhyay A, Faquin WC, Lin DT, Wirth LJ, Pierce RH, Pai SI

Cancer immunology, immunotherapy : CII　68　(8)　1273-1286　2019/08

DOI： 10.1007/s00262-019-02357-1 　

ISSN： 0340-7004

eISSN： 1432-0851
Characteristics of the Voice Handicap Index for Patients With Unilateral Vocal Fold Paralysis Who Underwent Arytenoid Adduction. International-journal Peer-reviewed

Kenichi Watanabe, Takeshi Sato, Yohei Honkura, Ai Kawamoto-Hirano, Kazutaka Kashima, Yukio Katori

Journal of voice : official journal of the Voice Foundation　34　(4)　649.e1-e6　2019/01/05

DOI： 10.1016/j.jvoice.2018.12.012 　

ISSN： 0892-1997

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PURPOSE: This study was performed to evaluate the characteristics of the Voice Handicap Index (VHI), a self-assessment measure, for patients with unilateral vocal fold paralysis (UVFP) who underwent arytenoid adduction (AA), in comparison with postoperative vocal function examinations. METHODS: A retrospective chart review was conducted for patients who underwent AA at Tohoku University Hospital during the period between 2014 and 2017. VHI was compared before and after surgery; moreover, correlations were assessed between the VHI and other voice measurements, including perceptual assessment of voice, as well as aerodynamic and acoustic measures. Factors involved in the VHI score were explored by multivariate analysis. RESULTS: Forty-three UVFP patients (28 males, age 32-81 years; 15 females, age 34-80 years) were enrolled in the study; the average age of all patients was 61.5 years (32-81 years). Among the enrolled patients, 33 (76.7%) left and 10 (23.3%) right vocal folds were impaired. After surgery, nearly all of the patients exhibited significantly improved VHI score; each of the three subscales (functional, physical, and emotional) was also improved. The postoperative VHI correlated mildly with several values of the other voice measurements, with the exception of the mean flow rate. Multivariate analysis showed that the sole variable associated with postoperative VHI score was preoperative VHI. CONCLUSIONS: The postoperative VHI likely reflects improvement in the voices of the patients with UVFP. Although there were weak correlations with other voice measures, postoperative VHI is a relatively independent measurement parameter for patients with UVFP who underwent AA.
Predictors of chewing and swallowing disorders after surgery for locally advanced oral cancer with free flap reconstruction: A prospective, observational study Peer-reviewed

Akira Ohkoshi, Takenori Ogawa, Ayako Nakanome, Eiichi Ishida, Ryo Ishii, Kengo Kato, Yukio Katori

Surgical Oncology　27　(3)　490-494　2018/09/01
Publisher: Elsevier Ltd
DOI： 10.1016/j.suronc.2018.05.029 　

ISSN： 1879-3320 0960-7404

eISSN： 1879-3320
Development of the Human Incus With Special Reference to the Detachment From the Chondrocranium to be Transferred into the Middle Ear. Peer-reviewed

Rodríguez-Vázquez JF, Yamamoto M, Abe S, Katori Y, Murakami G

Anatomical record (Hoboken, N.J. : 2007)　301　(8)　1405-1415　2018/08

DOI： 10.1002/ar.23832 　

ISSN： 1932-8486
Noninvasive aspiration detection using through-transmission ultrasound.

Yosuke Hara, Yukio Katori, Shigeaki Okumura, Hirofumi Taki, Hiroki Umeda, Tatsuya Uechi, Fumihiko Kawamura, Yoichi Haga, Ryoichi Nagatomi, Shin-Ichi Izumi

2018 IEEE 20th International Conference on e-Health Networking, Applications and Services, Healthcom 2018　1-5　2018
Publisher: IEEE
DOI： 10.1109/HealthCom.2018.8531081 　
Fetal development of the pulley for muscle insertion tendons: A review and new findings related to the tensor tympani tendon Peer-reviewed

Jose Francisco Rodriguez-Vazquez, Yohei Honkura, Yukio Katori, Gen Murakami, Hiroshi Abe

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER　209　1-10　2017

DOI： 10.1016/j.aanat.2016.09.001 　

ISSN： 0940-9602

eISSN： 1618-0402
Effects of Visual Speech on Early Auditory Evoked Fields - From the Viewpoint of Individual Variance Peer-reviewed

Izumi Yahata, Tetsuaki Kawase, Akitake Kanno, Hiroshi Hidaka, Shuichi Sakamoto, Nobukazu Nakasato, Ryuta Kawashima, Yukio Katori

PLOS ONE　12　(1)　e0170166　2017/01

DOI： 10.1371/journal.pone.0170166 　

ISSN： 1932-6203
Submucosal Elastic Laminae of the Middle and Lower Pharynx: A Histological Study Using Elderly Cadaveric Specimens Peer-reviewed

Ai Kawamoto-Hirano, Yohei Honkura, Masahito Yamamoto, Shin-ichi Abe, Gen Murakami, Yukio Katori

DYSPHAGIA　31　(5)　635-643　2016/10

DOI： 10.1007/s00455-016-9721-y 　

ISSN： 0179-051X

eISSN： 1432-0460
Relationship Between Clinical Test Results and Morphologic Severity Demonstrated by Sitting 3-D CT in Patients With Patulous Eustachian Tube Peer-reviewed

Ryoukichi Ikeda, Toshiaki Kikuchi, Hidetoshi Oshima, Hiromitsu Miyazaki, Hiroshi Hidaka, Tetsuaki Kawase, Yukio Katori, Toshimitsu Kobayashi

OTOLOGY & NEUROTOLOGY　37　(7)　908-913　2016/08

DOI： 10.1097/MAO.0000000000001102 　

ISSN： 1531-7129

eISSN： 1537-4505
Switching of the Laryngeal Cavity From the Respiratory Diverticulum to the Vestibular Recess: A Study Using Serial Sagittal Sections of Human Embryos and Fetuses Peer-reviewed

Masahito Yamamoto, Yohei Honkura, Jose Francisco Rodriguez-Vazquez, Gen Murakami, Yukio Katori, Baik Hwan Cho, Shin-ichi Abe

JOURNAL OF VOICE　30　(3)　263-271　2016/05

DOI： 10.1016/j.jvoice.2015.05.003 　

ISSN： 0892-1997

eISSN： 1873-4588
Cricoarytenoid Articulation in Elderly Japanese With Special Reference to Morphology of the Synovial Tissue Peer-reviewed

Ai Kawamoto-Hirano, Yohei Honkura, Shunichi Shibata, Shin-ichi Abe, Gen Murakami, Yukio Katori

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY　125　(3)　219-227　2016/03

DOI： 10.1177/0003489415606450 　

ISSN： 0003-4894

eISSN： 1943-572X
NRF2 Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea Peer-reviewed

Yohei Honkura, Hirotaka Matsuo, Shohei Murakami, Masayuki Sakiyama, Kunio Mizutari, Akihiro Shiotani, Masayuki Yamamoto, Ichiro Morita, Nariyoshi Shinomiya, Tetsuaki Kawase, Yukio Katori, Hozumi Motohashi

SCIENTIFIC REPORTS　6　19329　2016/01

DOI： 10.1038/srep19329 　

ISSN： 2045-2322
Clinical and bacteriological influence of diabetes mellitus on deep neck infection: Systematic review and meta-analysis Peer-reviewed

Hiroshi Hidaka, Takuhiro Yamaguchi, Jun Hasegawa, Hisakazu Yano, Risako Kakuta, Daiki Ozawa, Kazuhiro Nomura, Yukio Katori

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK　37　(10)　1536-1546　2015/10

DOI： 10.1002/hed.23776 　

ISSN： 1043-3074

eISSN： 1097-0347
Horizontal Basal Cell-Specific Deletion of Pax6 Impedes Recovery of the Olfactory Neuroepithelium Following Severe Injury Peer-reviewed

Jun Suzuki, Katsuyasu Sakurai, Maya Yamazaki, Manabu Abe, Hitoshi Inada, Kenji Sakimura, Yukio Katori, Noriko Osumi

STEM CELLS AND DEVELOPMENT　24　(16)　1923-1933　2015/08

DOI： 10.1089/scd.2015.0011 　

ISSN： 1547-3287

eISSN： 1557-8534
Ganglioside GM3 is essential for the structural integrity and function of cochlear hair cells Peer-reviewed

Misato Yoshikawa, Shinji Go, Shun-ichi Suzuki, Akemi Suzuki, Yukio Katori, Thierry Morlet, Steven M. Gottlieb, Michihiro Fujiwara, Katsunori Iwasaki, Kevin A. Strauss, Jin-ichi Inokuchi

HUMAN MOLECULAR GENETICS　24　(10)　2796-2807　2015/05

DOI： 10.1093/hmg/ddv041 　

ISSN： 0964-6906

eISSN： 1460-2083
Closure Technique for Labyrinthine Fistula by "Underwater" Endoscopic Ear Surgery Peer-reviewed

Daisuke Yamauchi, Muneharu Yamazaki, Jun Ohta, Seiichi Kadowaki, Kazuhiro Nomura, Hiroshi Hidaka, Takeshi Oshima, Tetsuaki Kawase, Yukio Katori

LARYNGOSCOPE　124　(11)　2616-2618　2014/11

DOI： 10.1002/lary.24785 　

ISSN： 0023-852X

eISSN： 1531-4995
Central-part laryngectomy is a useful and less invasive surgical procedure for resolution of intractable aspiration Peer-reviewed

Ai Kawamoto, Yukio Katori, Yohei Honkura, Risako Kakuta, Kenjiro Higashi, Masaki Ogura, Makiko Miyazaki, Kazuya Arakawa, Kazutaka Kashima, Yukinori Asada, Kazuto Matsuura

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY　271　(5)　1149-1155　2014/05

DOI： 10.1007/s00405-013-2725-4 　

ISSN： 0937-4477

eISSN： 1434-4726
Transsphenoidal meningocele: an anatomical study using human fetuses including report of a case Peer-reviewed

Yukio Katori, Ai Kawamoto, Kwang Ho Cho, Kiyoshi Ishii, Hiroshi Abe, Shinichi Abe, Jose Francisco Rodriguez-Vazquez, Gen Murakami, Tetsuaki Kawase

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY　270　(10)　2729-2736　2013/09

DOI： 10.1007/s00405-013-2392-5 　

ISSN： 0937-4477
Suprahyoid neck fascial configuration, especially in the posterior compartment of the parapharyngeal space: A histological study using late-stage human fetuses Peer-reviewed

Yukio Katori, Tetsuaki Kawase, Kwang Ho Cho, Hiroshi Abe, Jose Francisco Rodriguez-Vazquez, Gen Murakami, Mineko Fujimiya

CLINICAL ANATOMY　26　(2)　204-212　2013/03

DOI： 10.1002/ca.22088 　

ISSN： 0897-3806
Prestyloid compartment of the parapharyngeal space: a histological study using late-stage human fetuses Peer-reviewed

Yukio Katori, Tatsuaki Kawase, Kwang Ho Cho, Hiroshi Abe, Jose Francisco Rodriguez-Vazquez, Gen Murakami, Shinichi Abe

SURGICAL AND RADIOLOGIC ANATOMY　34　(10)　909-920　2012/12

DOI： 10.1007/s00276-012-0975-2 　

ISSN： 0930-1038
Early Fetal Development of the Intermediate Tendon of the Human Digastricus and Omohyoideus Muscles: A Critical Difference in Histogenesis Peer-reviewed

Yukio Katori, Ji Hyun Kim, Jose Francisco Rodriguez-Vazquez, Tetsuaki Kawase, Gen Murakami, Baik Hwan Cho

CLINICAL ANATOMY　24　(7)　843-852　2011/10

DOI： 10.1002/ca.21182 　

ISSN： 0897-3806
CD34-positive primitive vessels and other structures in human fetuses: An immunohistochemical study Peer-reviewed

Yukio Katori, Hiromichi Kiyokawa, Tetsuaki Kawase, Gen Murakami, Baik Hwan Cho

ACTA OTO-LARYNGOLOGICA　131　(10)　1086-1090　2011/10

DOI： 10.3109/00016489.2011.590152 　

ISSN： 0001-6489
Fetal development of the human epiglottis revisited: Appearance of GFAP-positive mesenchymal cells and fibrous connections with other laryngeal and lingual structures International-journal Peer-reviewed

Yukio Katori, Hiromi Takeuchi, Jose Francisco Rodríguez-Vázquez, Hiroya Kitano, Gen Murakami, Tetsuaki Kawase

Annals of Anatomy - Anatomischer Anzeiger　193　(2)　149-155　2011/03

DOI： 10.1016/j.aanat.2011.01.003 　

ISSN： 0940-9602

eISSN： 1618-0402
Early fetal development of hard tissue pulleys for the human superior oblique and tensor veli palatini muscles Peer-reviewed

Yukio Katori, Jose Francisco Rodriguez-Vazquez, Tetsuaki Kawase, Gen Murakami, Baik Hwan Cho, Shin-ichi Abe

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER　193　(2)　127-133　2011

DOI： 10.1016/j.aanat.2011.01.004 　

ISSN： 0940-9602

eISSN： 1618-0402
Smooth-to-striated muscle transition in human esophagus: An immunohistochemical study using fetal and adult materials Peer-reviewed

Yukio Katori, Baik Hwan Cho, Chang Ho Song, Mineko Fujimiya, Gen Murakami, Tetsuaki Kawase

Annals of Anatomy - Anatomischer Anzeiger　192　(1)　33-41　2010/02

DOI： 10.1016/j.aanat.2009.09.007 　

ISSN： 0940-9602

eISSN： 1618-0402
The dimensions and structural attachments of tip links in mammalian cochlear hair cells and the effects of exposure to different levels of extracellular calcium Peer-reviewed

D.N. Furness, Y. Katori, B. Nirmal Kumar, C.M. Hackney

Neuroscience　154　(1)　10-21　2008/06

DOI： 10.1016/j.neuroscience.2008.02.010 　

ISSN： 0306-4522
Differential distribution of β- and γ-actin in guinea-pig cochlear sensory and supporting cells Peer-reviewed

D.N. Furness, Y. Katori, S. Mahendrasingam, C.M. Hackney

Hearing Research　207　(1-2)　22-34　2005/09

DOI： 10.1016/j.heares.2005.05.006 　

ISSN： 0378-5955
Relationship between the local stiffness of the outer hair cell along the cell axis and its ultrastructure observed by atomic force microscopy. International-journal Peer-reviewed

Hiroshi Wada, Hiroto Usukura, Michiko Sugawara, Yukio Katori, Seiji Kakehata, Katsuhisa Ikeda, Toshimitsu Kobayashi

Hearing research　177　(1-2)　61-70　2003/03

DOI： 10.1016/S0378-5955(02)00798-0 　

ISSN： 0378-5955
Ultrastructure of lateral walls of outer hair cells observed by atomic force microscopy Peer-reviewed

H Wada, M Sugawara, H Usukura, K Kimura, Y Katori, S Kakehata, K Ikeda, T Kobayashi

BIOPHYSICS OF THE COCHLEA: FROM MOLECULES TO MODELS　136-143　2003
Late-onset hearing loss in a mouse model of DFN3 non-syndromic deafness: morphologic and immunohistochemical analyses. International-journal Peer-reviewed

An-Ping Xia, Toshihiko Kikuchi, Osamu Minowa, Yukio Katori, Takeshi Oshima, Tetsuo Noda, Katsuhisa Ikeda

Hearing research　166　(1-2)　150-8　2002/04

DOI： 10.1016/s0378-5955(02)00309-x 　

ISSN： 0378-5955
Increased von Willebrand factor in the endocardium as a local predisposing factor for thrombogenesis in overloaded human atrial appendage Peer-reviewed

M Fukuchi, J Watanabe, K Kumagai, Y Katori, S Baba, K Fukuda, T Yagi, A Iguchi, H Yokoyama, M Miura, Y Kagaya, S Sato, K Tabayashi, K Shirato

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY　37　(5)　1436-1442　2001/04

DOI： 10.1016/S0735-1097(01)01125-1 　

ISSN： 0735-1097
Expression of connexin 30 in the developing mouse cochlea Peer-reviewed

AP Xia, Y Katori, T Oshima, K Watanabe, T Kikuchi, K Ikeda

BRAIN RESEARCH　898　(2)　364-367　2001/04

DOI： 10.1016/S0006-8993(01)02216-8 　

ISSN： 0006-8993
Altered cochlear fibrocytes in a mouse model of DFN3 nonsyndromic deafness Peer-reviewed

O Minowa, K Ikeda, Y Sugitani, T Oshima, S Nakai, Y Katori, M Suzuki, M Furukawa, T Kawase, Y Zheng, M Ogura, Y Asada, K Watanabe, H Yamanaka, S Gotoh, M Nishi-Takeshima, T Sugimoto, T Kikuchi, T Takasaka, T Noda

SCIENCE　285　(5432)　1408-1411　1999/08

DOI： 10.1126/science.285.5432.1408 　

ISSN： 0036-8075
Ultrastructural localization of cadherin in the adult guinea-pig organ of Corti Peer-reviewed

S. Mahendrasingam, Y. Katori, D. N. Furness, C. M. Hackney

Hearing Research　111　(1-2)　85-92　1997/09

DOI： 10.1016/S0378-5955(97)00091-9 　

ISSN： 0378-5955
Restoration of the mucociliary clearance of the maxillary sinus after endoscopic sinus surgery Peer-reviewed

K. Ikeda, T. Oshima, M. Furukawa, Y. Katori, A. Shimomura, S. Takasaka

Journal of Allergy and Clinical Immunology　99　(1 I)　48-52　1997

DOI： 10.1016/S0091-6749(97)70299-9 　

ISSN： 0091-6749
Immunohistochemical localization of Gnathostoma spinigerum larval antigens by monoclonal antibodies: II. Electron microscopy Peer-reviewed

Wichit Rojekittikhun, Yukio Katori, Susumu Saito, Fujiro Sendo

Southeast Asian Journal of Tropical Medicine and Public Health　27　(3)　570-573　1996/09

ISSN： 0125-1562
WGA Lectin Binding Sites of the Apical Surface of Corti Epithelium: Enhancement by Back-Scattered Electron Imaging in Guinea-Pig Inner Ear Peer-reviewed

Y. Katori, A. Tonosaki, T. Takasaka

Journal of Electron Microscopy　45　(3)　207-212　1996/06/01
Publisher: Oxford University Press (OUP)
DOI： 10.1093/oxfordjournals.jmicro.a023434 　

ISSN： 0022-0744

eISSN： 1477-9986
Immunoreactivity of sensory hair bundles of the guinea-pig cochlea to antibodies against elastin and keratan sulphate Peer-reviewed

Yukio Katori, Carole M. Hackney, David N. Furness

Cell and Tissue Research　284　(3)　473-479　1996

DOI： 10.1007/s004410050608 　

ISSN： 0302-766X
Carbohydrate distribution in the living utricular macula of the guinea pig detected by lectins Peer-reviewed

Hideaki Suzuki, Yukio Katori, Katsuhisa Ikeda, Tomonori Takasaka

Hearing Research　87　(1-2)　32-40　1995/07

DOI： 10.1016/0378-5955(95)00075-F 　

ISSN： 0378-5955
ATP-induced increase in intracellular Ca²⁺ concentration in the cultured marginal cell of the stria vascularis of guinea-pigs Peer-reviewed

Masaaki Suzuki, Katsuhisa Ikeda, Hiroshi Sunose, Koji Hozawa, Chikashi Kusakari, Yukio Katori, Tomonori Takasaka

Hearing Research　86　(1-2)　68-76　1995/06

DOI： 10.1016/0378-5955(95)00055-9 　

ISSN： 0378-5955
Fine structure and lectin histochemistry of the apical surface of the free neuromast of Lampetra japonica Peer-reviewed

Yukio Katori, Tomonori Takasaka, Makoto Ishikawa, Akira Tonosaki

Cell and Tissue Research　276　(2)　245-252　1994/05

DOI： 10.1007/BF00306110 　

ISSN： 0302-766X

eISSN： 1432-0878
Practical pathological methods for reliable diagnosis of secretory carcinomas of the salivary gland. International-journal Peer-reviewed

Ryo Kawaura, Tomohiko Ishikawa, Hirofumi Shibata, Masashi Kuroki, Kazuhiro Kobayashi, Yuki Hanamatsu, Tatsuhiko Miyazaki, Hiroyuki Tomita, Takuma Ishihara, Hajime Usubuchi, Yayoi Aoyama, Yukinori Asada, Takayuki Imai, Akira Ohkoshi, Akira Hara, Yukio Katori, Toru Furukawa, Takenori Ogawa

Discover oncology　16　(1)　1254-1254　2025/07/03

DOI： 10.1007/s12672-025-03072-3 　

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Secretory carcinomas (SCs) of the salivary gland have recently been recognized as low-grade, malignant tumors. Before this designation, most SCs were diagnosed as variants of acinic cell carcinomas (AciCCs). SCs harbor the t(12;15)(p13;q25) translocation that generates an oncogenic fusion gene, ETS variant transcription factor 6/Neurotrophic tyrosine receptor kinase(ETV6::NTRK3). However, detecting fusion genes in a clinical setting is time-consuming and costly. In this study, we examined 31 cases previously diagnosed as AciCC and SC using pathological analyses with detection of fusion genes using ETV6 break-apart fluorescence in-situ hybridization and reverse transcription-polymerase chain reaction. After re-analysis, we found that these 31 cases actually comprised 21 SCs and 10 AciCCs. We examined the diagnostic utility of immunohistochemistry by comparing results with the fusion gene, Pan-Trk, which despite having recently been reported as effective for diagnosis of SC, was not universally accurate. However, combining mammaglobin and S-100 could be particularly useful in diagnosing SC. This practical method will contribute to accurate diagnosis of SCs, while saving time in daily clinical practice.
Association between the Hospital Anxiety and Depression Scale and Swallowing Function in Dysphagic Patients in Japan. International-journal Peer-reviewed

Takuma Hisaoka, Jun Suzuki, Ryoukichi Ikeda, Ai Hirano-Kawamoto, Jun Ohta, Yukio Katori

Auris, nasus, larynx　52　(3)　222-228　2025/06

DOI： 10.1016/j.anl.2025.03.001 　

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OBJECTIVE: Dysphagia affects 2.3 %-16 % of the general population and increases with age. It can lead to malnutrition, weight loss, aspiration pneumonia, and emotional symptoms such as anxiety and depression. Mental health disorders impact appetite and muscle mass, further worsening dysphagia. Additionally, cultural and economic factors influence anxiety and depression, which can either result from or contribute to dysphagia. Studies on the relationship between anxiety, depression, and swallowing function using FEES are limited in Asian populations. The Hospital Anxiety and Depression Scale (HADS) is a useful tool for assessing mood disorders. Therefore, in this study, we aimed to investigate the associations among anxiety, depression, and swallowing function in Japanese patients with dysphagia using HADS. METHODS: Data on age; sex; HADS; Eating Assessment Tool-10 (EAT-10); Functional Oral Intake Scale (FOIS); tongue pressure; Hyodo score, a scoring system for evaluating the swallowing function determined by flexible endoscopic evaluation of swallowing (FEES); and videofluoroscopic dysphagia scale (VDS), assessed by videofluoroscopic swallowing study, were collected and analyzed from medical records. Hyodo score consists of four parameters: (1) salivary pooling in the vallecula and piriform sinuses; (2) glottal closure reflex or cough reflex induced by touching the epiglottis or arytenoid; (3) swallowing reflex induced by colored water; and (4) extent of pharyngeal clearance after colored water is swallowed. The Mann-Whitney U test, Fisher's exact test, and multiple logistic regression analyses were used to estimate associations between HADS and swallowing function. RESULTS: No significant relationships were observed between the EAT-10, FOIS, and VDS with HADS scores. Patients with depression were associated with a significantly higher percentage of anorexia complaints (p = 0.047). Lower tongue pressure was observed in patients with depression than in patients without depression (p = 0.002). Patients with anxiety had better swallowing function, as assessed by the Hyodo score (p = 0.047). Fluid clearance, a component of the Hyodo score, was significantly better in patients with anxiety (p = 0.03) even after propensity score matching adjusted for the effects of age, sex, and fluid clearance. CONCLUSION: In patients with anxiety, swallowing function assessed by FEES was favorable, whereas a higher proportion of patients with depression reported decreased appetite, and lower tongue pressure. This discrepancy between subjective dysphagia and FEES findings suggests that patients with anxiety may underestimate their swallowing function.
Surgery for T1/2N0 Oropharyngeal Carcinoma Is a Better Treatment Option than Radiotherapy-A Long-Term Follow-Up Study from a Single Japanese High-Volume Cancer Center. International-journal Peer-reviewed

Masahiro Rokugo, Takeshi Shinozaki, Ryo Ishii, Yusuke Ito, Shingo Sakashita, Genichiro Ishii, Takenori Ogawa, Yukio Katori, Kazuto Matsuura, Ryuichi Hayashi

Cancers　17　(11)　2025/05/31

DOI： 10.3390/cancers17111862 　

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Background: The proportion of oropharyngeal cancers, especially those that are HPV-associated, is increasing, and both surgery and RT are considered effective initial treatments for early-stage oropharyngeal cancer, regardless of p16 status. However, there are still many unknowns regarding the long-term prognosis after initial treatment, the incidence rate of multiple cancers, and the relationship with p16 status. Methods: We retrospectively analyzed 94 cases of T1/2N0 oropharyngeal squamous cell carcinomas (OPSCCs) treated with surgery or radiotherapy between January 2000 and December 2012 at the Japan National Cancer Center Hospital East. The study items include long-term prognosis, p16 status, and the proportion of patients with multiple cancers after receiving treatment for oropharyngeal cancer. Results: The patients included 80 men and 14 women, whose median age was 68 (35-92). The median follow-up time was 2131 days. T1N0 cancer was observed in 34 patients and T2N0 in 60 patients. Surgery was performed for 74 patients, and radiotherapy for 20 patients. Of the patients who underwent surgery, 57 underwent transoral surgery, and 17 underwent pharyngectomy via transcervical approach. Nine of the 17 patients underwent partial pharyngectomy with free-flap reconstruction. The 5-year overall survival rates were 74.9 and 51.0% (p = 0.035); the 5-year disease-specific survival rates were 86.0 and 64.5% (p = 0.116); and the 5-year local control rates, 76.5 and 59.1% (p = 0.106) for the surgery and radiotherapy groups, respectively. Furthermore, 54 (57.4%) of the 94 cases suffered from multiple primary cancers, of which 29 (30.9%) were in the head and neck region and all were metachronous. Conclusions: Initial surgery for T1/2N0 OPSCCs is a proper therapeutic strategy considering the better overall survival and high incidence of multiple primary cancers.
Development of the occipitopetrosal junctions: A histological study using human fetuses. International-journal Invited

Ai Hirano-Kawamoto, Yohei Honkura, Chun-Ai Li, Samuel Verdugo-López, Gen Murakami, Jose Francisco Rodríguez-Vázquez, Yukio Katori

Anatomical record (Hoboken, N.J. : 2007)　2025/05/14

DOI： 10.1002/ar.25687 　

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The temporal bone petrosa is connected to the occipital bone at two sites: one junction with the basilar part (medial junction) and another with the lateral part (lateral junction). Using histological specimens from 45 human fetuses (approximately 7-39 weeks of gestational age or GA), we aimed to describe possible changes in histology and topographical anatomy during processes toward the ossified union. In the early term, the junctions were characterized by dense mesh-like fibers that likely corresponded to the thickened basal laminae of the composite cartilage cells. Notably, the mesh-like structure disappeared until 12 weeks of GA and, irrespective of whether a remnant fibrous tissue was present or absent, cartilage tissues became continuous between the occipital and petrosal sides. Until 25 weeks of GA, the inferolateral marginal part of the spheno-occipital junction cartilage extended to the medial junction and attached to the ossified petrosa. The medial junction sometimes contained an irregularly shaped cartilage mass or a woven bone with bone trabeculae, but it was usually attached directly to the bony petrosa without any interruption by calcified cells. In contrast, at the late-term lateral junction, a cartilage mass was sandwiched by bipolar ossification centers on the temporal and occipital bone sides. As the endochondral ossification advances, bones at and around the lateral junction seemed to grow and cover the expanding mastoid air cells. However, the fetal medial junction might grow, in accordance with midline growth at the spheno-occipital junction cartilage. Alternatively, the bony union of these two junctions might establish postnatally.
Endoscopic-Assisted Tonsillectomy With Preemptive Hemostasis and Low-Output Bipolar Energy: A Strategy to Reduce Postoperative Hemorrhage. International-journal Invited

Haruka Ota, Takuya Yoshida, Keita Suzuki, Kazutake Yagi, Kenjiro Higashi, Akira Ohkoshi, Yukio Katori

Cureus　17　(5)　e84933　2025/05

DOI： 10.7759/cureus.84933 　

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Introduction Tonsillectomy is a common surgical procedure in otolaryngology; however, postoperative hemorrhage remains a serious complication. Although novel hemostatic devices have been introduced, no definitive preventive strategy has been established. This study evaluated a standardized surgical approach combining preemptive hemostasis, reduced energy device output, and endoscopic assistance to minimize postoperative complications. Methods This single-center, non-randomized, observational cohort study included 137 patients aged 15 years or older who underwent extracapsular tonsillectomy between April 2018 and March 2025. Patients were grouped based on the time period of treatment: those who underwent conventional tonsillectomy between 2018 and 2021 comprised the Conventional Group (n = 85), and those who underwent a standardized procedure incorporating preemptive hemostasis and low-output energy devices between 2022 and 2025 comprised the Standardized Group (n = 52). Perioperative outcomes, postoperative hemorrhage rates, pain control, and hospital stay length were compared between groups using the Mann-Whitney U test and Fisher's exact test (p < 0.05 was considered significant). Results The Standardized Group showed a significantly lower postoperative hemorrhage rate (0% vs. 9.5%, p = 0.0236) and less intraoperative blood loss (0.42 ± 1.01 mL vs. 8.31 ± 26.7 mL, p = 0.0031) compared to the Conventional Group. Although operative time was longer (83.5 ± 33.3 min vs. 56.5 ± 23.8 min, p < 0.001), the Standardized Group had a shorter hospital stay (8.86 ± 1.24 days vs. 10.1 ± 1.15 days, p < 0.001) and required fewer rescue analgesic interventions (p = 0.0178). Conclusion The combination of preemptive hemostasis, reduced energy output, and endoscopic supervision significantly improved surgical outcomes, reduced complications, and enhanced the educational experience for junior surgeons. This protocol represents a standardized, cost-effective technique that enhances safety and surgical training.
Risk factors of pneumonia after thoracic aortic surgery. International-journal Peer-reviewed

Akari Sawada, Jun Suzuki, Yusuke Suzuki, Ryoukichi Ikeda, Jun Ohta, Ai Hirano-Kawamoto, Yoshikatsu Saiki, Yukio Katori

Auris, nasus, larynx　52　(2)　167-173　2025/04

DOI： 10.1016/j.anl.2025.02.002 　

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OBJECTIVE: Pneumonia is a common complication and a significant cause of mortality following cardiovascular surgery. This study aimed to investigate the incidence and risk factors for pneumonia after thoracic aortic surgery. METHODS: A retrospective review was conducted on the medical records of 380 patients who underwent thoracic aortic surgery between January 2016 and December 2019. Patients were classified into pneumonia and non-pneumonia groups based on postoperative outcomes. Pneumonia was further categorized as aspiration pneumonia, ventilation-associated pneumonia (VAP), or other types. Risk factors were identified through univariate and multivariate analyses. RESULTS: Postoperative pneumonia during hospitalization occurred in 30 patients (7.9 %), including 18 cases of aspiration pneumonia (4.7 %) and 9 cases of VAP (2.4 %). Risk factors identified included hoarseness before surgery, aortic arch replacement, longer anesthesia time, longer intubation duration, necessity for tracheostomy, cerebrovascular disease after surgery, and postoperative recurrent laryngeal nerve paralysis. Multivariate analysis suggested that hoarseness before surgery and the necessity for tracheostomy were independent risk factors for pneumonia during hospitalization. CONCLUSION: This study identified key risk factors for postoperative pneumonia after thoracic aortic surgery. These findings may aid in identifying high-risk patients and implementing preventive strategies to reduce postoperative pneumonia.
Sensorineural hearing loss after concurrent chemoradiotherapy with high-dose cisplatin in head and neck cancer patients: Roles of nutrition and trace elements. International-journal Peer-reviewed

Akira Ohkoshi, Ryo Ishii, Kenjiro Higashi, Satoshi Toyoma, Tadahisa Shishido, Takaya Yamamoto, Hinako Harada, Ayako Nakanome, Yukio Katori

Auris, nasus, larynx　52　(2)　141-145　2025/04

DOI： 10.1016/j.anl.2025.01.013 　

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OBJECTIVE: Sensorineural hearing loss (SNHL) is one of the most important adverse events of concurrent chemoradiotherapy (CCRT) with high-dose cisplatin for locally advanced head and neck squamous cell carcinoma (HNSCC). This retrospective study aimed to elucidate the effects of nutritional status and trace elements on the development of SNHL. METHODS: A retrospective review of 211 ears from 109 patients with HNSCC who underwent CCRT with high-dose cisplatin was performed. SNHL of each ear was classified according to Common Terminology Criteria for Adverse Events (CTCAE) version 5.0, and possible contributing factors were evaluated by univariate and multivariate analyses. Age, sex, primary site, clinical stage, treatment intent, smoking and drinking habits, history of hypertension, diabetes mellitus, body mass index, serum albumin, trace elements (Fe, Zn, Cu, Se), pretreatment average hearing level at 2-8 kHz, weight loss rate, cumulative cisplatin dose, and inner ear radiation dose were the variables evaluated. RESULTS: Ordinal logistic regression analysis showed that increased age, better pretreatment average hearing level at 2-8 kHz, and cumulative cisplatin dose were independent factors associated with the development of SNHL. CONCLUSION: Nutritional status and trace elements were not associated with the development of SNHL caused by CCRT with high-dose cisplatin.
Effect of acute ethanol intoxication on swallowing function in mice. International-journal Peer-reviewed

Takuma Hisaoka, Jun Suzuki, Ryoukichi Ikeda, Jun Ohta, Hiyori Takahashi, Yukio Katori

Auris, nasus, larynx　52　(2)　101-106　2025/04

DOI： 10.1016/j.anl.2025.01.004 　

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OBJECTIVES: Ethanol consumption may lead to various symptoms depending on its concentration in the blood. Acute ethanol intoxication is a major risk factor for bolus -aspiration; however, studies on the effects of acute ethanol intoxication on swallowing are lacking. Therefore, we investigated the effect of acute ethanol intoxication on mice using the videofluoroscopic swallowing study (VFSS) methodology. METHODS: Male C57BL/6 J mice were randomly allocated into three groups: saline injection, 2 g/kg ethanol injection, and 4 g/kg ethanol injection. The VFSS technique was used to analyze the inter-swallow interval, lick-swallow rate, lick rate, bolus area, pharyngeal transit time, bolus speed, and bolus area 3 d before injection (control), 2 h after injection, and 8 h after injection. RESULTS: In the 4 g/kg ethanol injection group, the inter-swallow interval and lick-swallow rate increased after 2 h However, these changes were reversed 8 h after ethanol administration. Additionally, the pharyngeal transit time, bolus speed, and bolus area did not change significantly after ethanol administration. CONCLUSIONS: The present study reveals that ethanol administration delays bolus transport in the mouth but does not affect pharyngeal swallowing reflexes and reflex thresholds. Acute ethanol intoxication specifically impairs the oral function as assessed by the VFSS.
Locally advanced maxillary sinus cancer fed from the internal carotid artery. International-journal Peer-reviewed

Tatsuhiko Yamada, Masashi Kuroki, Hirofumi Shibata, Shoma Nagata, Hiroshi Kawada, Hiroki Kato, Akira Ohkoshi, Ikuho Kojima, Ryota Iinuma, Hiroshi Okuda, Yukio Katori, Masayuki Matsuo, Takenori Ogawa

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery　2025/03/28

DOI： 10.1007/s00405-025-09343-7 　

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OBJECTIVE: Superselective intra-arterial infusion of cisplatin and concomitant radiation therapy (RADPLAT) is one of the effective treatments for advanced maxillary sinus cancer, and prospective trials have been conducted. However, treatment of cases with intraorbital infiltration or skull base infiltration that are fed from the internal carotid artery (ICA) may be problematic. In this study, we investigated the frequency, treatment, and prognosis of locally advanced maxillary sinus cancer fed from the ICA. METHOD: This study included patients with locally advanced maxillary sinus cancer (clinical T4a or T4b) who underwent RADPLAT only via external carotid artery from January 2008 to January 2024. RESULT: Nineteen of 44 cases were fed from the ICA (43.2%). Three-year overall survival (OS), three-year progression-free survival (PFS), and three-year local control rate (LCR) of all cases were 69.8%, 47.5%, and 61.8%, respectively. The three-year OS, PFS and LCR were equivalent between cases with or without feeding from the ICA. CONCLUSION: This study revealed the frequency and prognosis of locally advanced maxillary sinus cancer fed from the ICA. The prognosis was equivalent between cases with or without feeding from the ICA; therefore, it would be considered important to determine the tumor volume for each feeding blood vessel and assess the areas of dual perfusion.
Branched ends of Reichert's cartilage in the ear: a histological study using human near-term fetuses. International-journal

Chun-Ai Li, Zhe-Wu Jin, Yohei Honkura, Ai Hirano-Kawamoto, Gen Murakami, Jose Francisco Rodríguez-Vázquez, Yukio Katori

Anatomy & cell biology　2025/02/26

DOI： 10.5115/acb.24.220 　

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There is little information regarding whether the styloid process "inserts" deeply into the temporal bone petrosa. We examined the involvement of Reichert's cartilage (RC) in the petrosa using sagittal or horizontal histological sections of the heads from 17 near-term fetuses (25-40 weeks). The cranial part of RC usually carried two short branches or protrusions (T-shaped appearance). One of the branches ended in or adjacent to the future tympanic cavity, while another branch ended near the facial nerve canal. Near the latter end, a part of the RC was usually fused with the petrosa, but it was rarely separated from the latter. When a bar toward the tympanic cavity was short or absent, RC displayed a reversed J-shaped course near the facial nerve canal and ended at the attachment to the petrosa (3 of 17 specimens). Overall, considerable variations were evident in the shape, length and topographical relation of RC in the ear. Therefore, an intra-otic root of the styloid process, if identified in adults, seemed not to be a simple bar inserting between the tympanic cavity and the vertical portion of the facial nerve canal. Considerable variations in the RC head suggested that the shape was likely to be determined by mechanical loads from the developing petrosa and/or tympanic bone. Those observations were clearly contrast to the degenerating Meckel's cartilage that induces protrusions of the petrosa ant tympanic bone. After birth, endochondral ossification of the petrosa appeared to expand antero-inferiorly to involve all branches of RC.
A mutation in Tmem135 causes progressive sensorineural hearing loss. International-journal

Mi-Jung Kim, Shion Simms, Ghazaleh Behnammanesh, Wei-Wen Chen, Yohei Honkura, Jun Suzuki, Hyo-Jin Park, Marcus Milani, Yukio Katori, Jonathan E Bird, Akihiro Ikeda, Shinichi Someya

Hearing research　459　109221-109221　2025/02/14

DOI： 10.1016/j.heares.2025.109221 　

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Transmembrane protein 135 (TMEM135) is a highly conserved 52 kDa protein with five predicted transmembrane domains that colocalizes with mitochondria and peroxisomes. Previous studies have shown that TMEM135 is involved in mitochondrial dynamics, thermogenesis, and lipid metabolism across multiple tissues and species; however, its role in the inner ear and auditory system remains unknown. We investigated the function of TMEM135 in hearing using wild-type (WT) and Tmem135FUN025/FUN025 (FUN025) mutant mice on a CBA/CaJ background, a normal-hearing mouse strain. Although FUN025 mice displayed normal auditory brainstem response (ABR) thresholds at 1 month, we observed significantly elevated ABR thresholds at 8, 16, and 64 kHz by 3 months, which progressed to profound hearing loss by 12 months. Consistent with our auditory testing results, 13-month-old FUN025 mice exhibited a severe loss of outer hair cells and more modest changes in inner hair cell survival, spiral ganglion neuron density, and stria vascularis integrity in the cochlea. Our results using BaseScope RNA in situ hybridization indicate that TMEM135 is expressed in the inner hair cells, outer hair cells, supporting cells, and stria vascularis. Using Volocity software and Costes colocalization analysis, we found that TMEM135 closely colocalizes with mitochondria in hair cells. Together, these results demonstrate that the FUN025 mutation in Tmem135 causes progressive sensorineural hearing loss, and suggest that TMEM135 is crucial for maintaining key cochlear cell types and normal sensory function in the aging cochlea.
A nationwide survey of dysphagia as a complication of deep neck infection with abscess in Japan. International-journal Peer-reviewed

Rina Kato, Ryota Iinuma, Hiroshi Hidaka, Kenichi Mori, Hirofumi Shibata, Hiroshi Okuda, Kosuke Terazawa, Natsuko Obara, Yukio Katori, Takenori Ogawa

Auris, nasus, larynx　52　(1)　84-89　2025/02

DOI： 10.1016/j.anl.2024.12.009 　

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OBJECTIVE: Deep neck infection with abscess (DNI) may cause dysphagia as a late complication. This study aimed to determine the rate of DNI related dysphagia (DNIRD) and the effectiveness of rehabilitation and surgery for DNIRD. METHODS: As a multicenter retrospective study, we conducted a nationwide survey by sending questionnaires to specialist training institutions certified by the Japan Broncho-esophagological Society (JBES). The questionnaire was sent to 227 facilities. This survey targeted patients with DNI aged 20 years or older who were hospitalized after April 1, 2011 and discharged by March 31, 2021. RESULTS: Of the 1058 cases of DNI included in this study, DNIRD was observed in 161 of 1058 patients (15.2 %). Of the 1058 cases of DNI, 139 cases showed descending necrotizing mediastinitis (DNM) (13.1 %), and DNIRD was observed in 64 of the DNM cases (46 %). DNIRD cases tended to be older (71 ± 13.5 vs. 64 ± 17.7 years old, p < 0.001), have a higher tracheostomy rate (91.3 % vs. 43.7 %, p < 0.0001), and have a longer hospital stay (51 ± 34.7 vs. 17 ± 15.4 days, p < 0.0001) than non-DNIRD cases. There were 125 cases in which only rehabilitation was performed, 8 cases in which surgery was performed to improve swallowing function, and 28 cases in which the natural course was observed. The improvement rates of DNIRD in the natural history group, rehabilitation group, and surgery group were 78.6 %, 91.8 %, and 100 %, respectively, and the rehabilitation group tended to improve more than the natural course group (p = 0.08). CONCLUSION: This nationwide survey revealed that 15.2 % of patients with DNI resulted in DNIRD and that 46 % of descending necrotizing mediastinitis patients developed DNIRD. Rehabilitation for DNIRD is generally useful, and that additional surgical treatment can improve outcomes for DNIRD patients where rehabilitation alone is not effective.
Time-course changes in videofluoroscopic findings during developmental and aging stages in mice. International-journal Peer-reviewed

Hiyori Takahashi, Jun Suzuki, Ryoukichi Ikeda, Takuma Hisaoka, Yasutoshi Koshiba, Jun Ohta, Ai Hirano-Kawamoto, Yukio Katori

Neuroreport　2025/01/22

DOI： 10.1097/WNR.0000000000002140 　

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Videofluoroscopic swallow study methodology in mice has recently been established; however, details of developmental and age-related changes remain unclear. This study aimed to reveal the changes in swallowing associated with the entire lifespan of mice using the videofluoroscopic swallow study methodology. We tested six age groups of male C57BL/6J mice (4, 8, 16, 54, 77, and 104 weeks old; n = 5 for each group, respectively). The videofluoroscopic swallow study analyzed the bolus area, pharyngeal transit time, interswallow interval, lick-swallow ratio, and lick rate. Significant age differences were found in the bolus area and lick rate. The bolus area increased significantly as the mice grew older. There was a significant increase in the lick rate from 4 to 8 weeks (P < 0.001) and then a significant decrease from 8 to 104 weeks (P < 0.01). No significant difference was observed between the various stages in the lick-swallow ratio, interswallow interval, or pharyngeal transit time. There was a significant positive correlation between the body weight and bolus area. This study revealed the detailed changes in swallowing at each life stage from swallowing maturation to old age in the mice. Our research may serve as a guide for future studies on swallowing in humans.
Predictors of recurrence and survival after salivary gland cancer surgery: A multicenter, retrospective study in northern Japan. International-journal

Akira Ohkoshi, Ryo Ishii, Kenjiro Higashi, Tadahisa Shishido, Satoshi Kano, Takahiro Kusaka, Daisuke Matsushita, Kosuke Murayama, Yuya Miyakura, Satoshi Kubota, Ryosuke Sato, Shino Godo, Hiroki Tomizawa, Satoshi Toyoma, Ai Tagawa, Akina Shirotori, Yukio Katori

Oral oncology　160　107131-107131　2025/01

DOI： 10.1016/j.oraloncology.2024.107131 　

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OBJECTIVES: Salivary gland cancer is a rare disease composed of more than 20 histological types with different grades of malignancy. The aim of this multicenter, retrospective study was to identify the most important predictors affecting recurrence and survival after surgery. MATERIAL AND METHODS: A total of 543 patients with salivary gland cancers that underwent curative surgery between 2012 and 2022 in 13 institutions in northern Japan were evaluated in this study. Predictors affecting recurrence and survival were identified by univariate and multivariate Cox regression analyses. Age, sex, primary site, histological type, pathological T status, surgical margin, lymph node metastasis, extranodal extension, and postoperative radiotherapy were the variables evaluated. RESULTS: Multivariate Cox regression analysis showed that increasing age, submandibular cancer, pathological T status 3 or 4, positive surgical margin, and lymph node metastasis, especially with extranodal extension, were independent risk factors for both recurrence and survival. Sublingual cancer was an independent risk factor for recurrence. Postoperative radiotherapy was associated with a lower risk of recurrence and a good prognosis, and adenoid cystic carcinoma was associated with a good prognosis. CONCLUSION: Lymph node metastasis with extranodal extension was the most important prognostic factor affecting both recurrence and survival after surgery, adenoid cystic carcinoma was associated with a good prognosis, and postoperative radiotherapy was associated with a lower risk of recurrence and a good prognosis.
CT scoring system for differentiating of sinonasal inverted papilloma and squamous cell carcinoma arising from inverted papilloma. International-journal Peer-reviewed

Miki Umeda, Masashi Kuroki, Hiroki Kato, Hirofumi Shibata, Nansei Yamada, Hiroshi Okuda, Kosuke Terazawa, Ryota Iinuma, Akira Ohkoshi, Shun Wakamori, Ikuho Kojima, Yukio Katori, Masayuki Matsuo, Takenori Ogawa

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery　2024/12/12

DOI： 10.1007/s00405-024-09107-9 　

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OBJECTIVE: To distinguish squamous cell carcinoma in inverted papilloma (IP-SCC) from IP, the utility of CT scoring system was investigated. METHODS: We extracted cases histopathologically diagnosed with IP and IP-SCC of the sinonasal cavity from June 2004 to May 2021. Preoperative unenhanced CT images were used to evaluate the presence or absence of bone destruction and erosion: Score 1 = positive for bone destruction and/or erosion; Score 0 = negative for bone destruction and erosion. The CT scores in 10 sites of the sinonasal cavity and their adjacent areas were calculated. RESULTS: Fifty-six cases of IP and 20 cases of IP-SCC were enrolled in this study. Bone destruction and/or erosion was more frequently observed in IP-SCC than in IP at the sites of the skull base (p = 0.0001), orbital wall (p < 0.0001), maxillary sinus (p < 0.0001), nasal septum (p < 0.0001), inferior nasal concha (p = 0.0046), ethmoid sinus (p < 0.0001), pterygoid process (p = 0.0031), and frontal sinus (p = 0.0009). The total CT scores at the 10 sites for diagnosing IP-SCC had sensitivity and specificity of 70% and 87.5% (AUC: 0.810, p < 0.001); furthermore, those at the eight sites excluding fontanelle and middle nasal concha improved sensitivity and specificity of 75% and 83.9% (optimal threshold of 2, AUC: 0.862, p < 0.001). CONCLUSION: The CT scoring system evaluating bone destruction and erosion could accurately differentiate IP-SCC from IP.
Rising-frequency chirp stimuli effectively enhance the amplitude and shorten the latency of 40-hz auditory steady-state response. International-journal

Shunsuke Takai, Takashi Morimoto, Akitake Kanno, Tetsuaki Kawase, Jun Suzuki, Nobukatsu Nakasato, Ryuta Kawashima, Yukio Katori

International journal of audiology　1-8　2024/12/10

DOI： 10.1080/14992027.2024.2430765 　

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OBJECTIVE: To evaluate the effects of changes in group delay from a click signal to a chirp signal on the 40-Hz Auditory Steady-State Response (ASSR) using magnetoencephalography (MEG). DESIGN: In this study, each participant was exposed to 10 chirp signals with gradually varying group delays from the CE chirp to the click at 60 dB nHL. The 40-Hz ASSR was measured using MEG and evaluated for amplitude and latency in the maximum signal channel at the click signal measured in each hemisphere. STUDY SAMPLE: Ten native Japanese speakers without histories of auditory diseases (8 males and 2 females, mean age 28.4 ± 5.70 years) participated in the study. RESULTS: The 40-Hz ASSR amplitude increased with the group delay of the chirp signal, was most efficient with the CE-chirp (longest group delay) and was significantly larger in the contralateral hemisphere for the CE-chirp than with the click signal. No significant differences were observed in ipsilateral hemispheres. The latency of the 40-Hz ASSR decreased as the group delay of the chirp signal increased. CONCLUSIONS: This study demonstrated that chirp signals, particularly the CE chirp, are more efficient than click signals in eliciting a 40-Hz ASSR, especially in the contralateral hemisphere.
Development and growth of fasciae in and around the esophageal hiatus: a histological study using human fetuses. International-journal Peer-reviewed

Ai Hirano-Kawamoto, Yohei Honkura, Gen Murakami, Shin-Ichi Abe, Jose Francisco Rodríguez-Vázquez, Yukio Katori

Surgical and radiologic anatomy : SRA　47　(1)　16-16　2024/12/02

DOI： 10.1007/s00276-024-03517-4 　

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PURPOSE: An entire fascial configuration at the esophageal hiatus might not be demonstrated histologically. According to observations of human fetus histology, the aim of this study was to consider which factor is likely to make the individual variation in adults. METHODS: We observed frontal histological sections containing the esophageal hiatus from 12 midterm fetuses at 12-16 weeks (crown-rump length: CRL, 85-137 mm) and 10 near-term fetuses at 26-30 weeks (CRL, 214-250 mm). RESULTS: At midterm, the transversalis fascia covering the diaphragm turned upward to join the adventitia of the left aspect of the esophagus: thus, the upper leaflet of the phreno-esophageal membrane was established first. A connection between the adventitia and endothoracic fascia (i.e., the upper leaflet of the PEM) was deleyed in the right. At near-term, both the transversalis and endothoracic fasciae often joined the adventitia in the left side but not in the right side. Therefore, fascial development advanced in the left side as well as the inferior side of the hiatus. The foregut-midgut junction, suggested with cytokeratin 5/6 immunostaining, was located in the hiatus. CONCLUSION: Development and growth of the phreno-esophageal membrane showed left/right and superior/inferior differences. The transiently-appeared pleural recess, the upward protruding right crus of diaphragm and, the right liver and adrenal extending upward seemed to disturb the fascial connection to the adventitia in the right and/or superior side. Individual variations in the fascial configuration at the hiatus might occur due to the site-dependent delay of the establishment of structures.
Nationwide Survey on Incidence and Management of Recurrent Respiratory Papillomatosis in Japan. International-journal

Shigeyuki Murono, Tomotaka Kawase, Hiroumi Matsuzaki, Tomohiro Hasegawa, Kazuya Kurakami, Rumi Ueha, Hiroaki Tadokoro, Yoshikazu Kikuchi, Yasushi Toh, Akihiro Shiotani, Yukio Katori

The Laryngoscope　2024/11/29

DOI： 10.1002/lary.31932 　

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OBJECTIVES: To investigate the incidence, laryngeal distribution, management, and postoperative clinical course of patients with newly diagnosed adult-onset recurrent respiratory papillomatosis (RRP) in Japan. METHODS: An initial brief questionnaire was sent to 782 institutions, including all 101 core and 627 collaborating institutions providing board certification programs accredited by the Japanese Society of Otorhinolaryngology-Head and Neck Surgery. A detailed questionnaire regarding patient age, sex, Derkay's score, surgery, and postoperative clinical course was sent to 196 institutions caring for patients with either newly or previously diagnosed RRP. RESULTS: A total of 186 patients with newly diagnosed adult-onset RRP from 78 institutions were identified during the present study period (2018-2019), suggesting an annual incidence of 0.20 per 100,000 population in Japan. The true vocal folds were the most frequently affected subsites in the larynx, followed by the false vocal folds, anterior commissure, and laryngeal surface of the epiglottis. The use of cold instruments was the most preferred surgical approach, followed by the carbon dioxide laser and microdebrider. A significant difference in recurrence-free period after the initial surgery was observed between patients with lesions in a single region and those with lesions in multiple regions (p = 0.001). CONCLUSION: Here, we estimated the annual incidence of adult-onset RRP for the first time in Japan. To the best of our knowledge, the present study is the largest to identify the laryngeal distribution of lesions, as well as postoperative outcomes after initial surgery in newly diagnosed adult-onset RRP patients. LEVEL OF EVIDENCE: 4 Laryngoscope, 2024.
Nrf2 Deficiency Exacerbates the Decline in Swallowing and Respiratory Muscle Mass and Function in Mice with Aspiration Pneumonia. International-journal Peer-reviewed

Hikaru Hashimoto, Tatsuma Okazaki, Yohei Honkura, Yuzhuo Ren, Peerada Ngamsnae, Takuma Hisaoka, Yasutoshi Koshiba, Jun Suzuki, Satoru Ebihara, Yukio Katori

International journal of molecular sciences　25　(21)　2024/11/04

DOI： 10.3390/ijms252111829 　

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Aspiration pneumonia exacerbates swallowing and respiratory muscle atrophy. It induces respiratory muscle atrophy through three steps: proinflammatory cytokine production, caspase-3 and calpain, and then ubiquitin-proteasome activations. In addition, autophagy induces swallowing muscle atrophy. Nrf2 is the central detoxifying and antioxidant gene whose function in aspiration pneumonia is unclear. We explored the role of Nrf2 in aspiration pneumonia by examining swallowing and respiratory muscle mass and function using wild-type and Nrf2-knockout mice. Pepsin and lipopolysaccharide aspiration challenges caused aspiration pneumonia. The swallowing (digastric muscles) and respiratory (diaphragm) muscles were isolated. Quantitative RT-PCR and Western blotting were used to assess their proteolysis cascade. Pathological and videofluoroscopic examinations evaluated atrophy and swallowing function, respectively. Nrf2-knockouts showed exacerbated aspiration pneumonia compared with wild-types. Nrf2-knockouts exhibited more persistent and intense proinflammatory cytokine elevation than wild-types. In both mice, the challenge activated calpains and caspase-3 in the diaphragm but not in the digastric muscles. The digastric muscles showed extended autophagy activation in Nrf2-knockouts compared to wild-types. The diaphragms exhibited autophagy activation only in Nrf2-knockouts. Nrf2-knockouts showed worsened muscle atrophies and swallowing function compared with wild-types. Thus, activation of Nrf2 may alleviate inflammation, muscle atrophy, and function in aspiration pneumonia, a major health problem for the aging population, and may become a therapeutic target.
Antitumor activities of anti‑CD44 monoclonal antibodies in mouse xenograft models of esophageal cancer. International-journal

Kenichiro Ishikawa, Hiroyuki Suzuki, Tomokazu Ohishi, Takuro Nakamura, Miyuki Yanaka, Guanjie Li, Tomohiro Tanaka, Akira Ohkoshi, Manabu Kawada, Mika K Kaneko, Yukio Katori, Yukinari Kato

Oncology reports　52　(5)　2024/11

DOI： 10.3892/or.2024.8806 　

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CD44 is a type I transmembrane glycoprotein associated with poor prognosis in various solid tumors. Since CD44 plays a critical role in tumor development by regulating cell adhesion, survival, proliferation and stemness, it has been considered a target for tumor therapy. Anti‑CD44 monoclonal antibodies (mAbs) have been developed and applied to antibody‑drug conjugates and chimeric antigen receptor‑T cell therapy. Anti-pan‑CD44 mAbs, C44Mab‑5 and C44Mab‑46, which recognize both CD44 standard (CD44s) and variant isoforms were previously developed. The present study generated a mouse IgG2a version of the anti‑pan‑CD44 mAbs (5‑mG2a and C44Mab‑46‑mG2a) to evaluate the antitumor activities against CD44‑positive cells. Both 5‑mG2a and C44Mab‑46‑mG2a recognized CD44s‑overexpressed CHO‑K1 (CHO/CD44s) cells and esophageal tumor cell line (KYSE770) in flow cytometry. Furthermore, both 5‑mG2a and C44Mab‑46‑mG2a could activate effector cells in the presence of CHO/CD44s cells and exhibited complement-dependent cytotoxicity against both CHO/CD44s and KYSE770 cells. Furthermore, the administration of 5‑mG2a and C44Mab‑46‑mG2a significantly suppressed CHO/CD44s and KYSE770 xenograft tumor development compared with the control mouse IgG2a. These results indicate that 5‑mG2a and C44Mab‑46‑mG2a could exert antitumor activities against CD44‑positive cancers and be a promising therapeutic regimen for tumors.
Esophagectomy for esophageal cancer in patients with a history of total pharyngolaryngectomy: a Japanese nationwide retrospective cohort study.

Akihiko Okamura, Masayuki Watanabe, Jun Okui, Kengo Kuriyama, Osamu Shiraishi, Takanori Kurogochi, Tetsuya Abe, Hiroshi Sato, Hiroshi Miyata, Yoshihiko Kawaguchi, Yusuke Sato, Hiroaki Nagano, Shinsuke Takeno, Masanobu Nakajima, Kentaro Matsuo, Kentaro Murakami, Katsushi Takebayashi, Sohei Matsumoto, Tomoyuki Okumura, Yoshihiro Kakeji, Koji Kono, Nobuhiko Oridate, Yasushi Toh, Hiroya Takeuchi, Yukio Katori

Esophagus : official journal of the Japan Esophageal Society　21　(4)　438-446　2024/10

DOI： 10.1007/s10388-024-01078-4 　

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BACKGROUND: Second primary esophageal cancer often develops in patients with head and neck cancer, and esophagectomy in patients with a history of total pharyngolaryngectomy (TPL) is challenging. However, the clinical outcomes of these patients have yet to be examined in a multicenter setting. METHODS: We evaluated the surgical outcomes of a nationwide cohort of 62 patients who underwent esophagectomy for esophageal cancer with a history of TPL. RESULTS: Ivor-Lewis and McKeown esophagectomies were performed in 32 (51.6%) and 30 (48.4%) patients, respectively. Postoperatively, 23 patients (37.1%) developed severe complications, and 7 patients (11.3%) required reoperation within 30 days. Pneumonia and anastomotic leakage occurred in 13 (21.0%) and 16 (25.8%) patients, respectively. Anastomotic leakage occurred more frequently in the McKeown group than in the Ivor-Lewis group (46.7% vs. 6.2%, P < 0.001). The adjusted odds ratio for anastomotic leakage in the McKeown group was 9.64 (95% confidence intervals (CI), 2.11-70.82, P = 0.008). Meanwhile, the 5-year overall survival rates were comparable between the groups (41.8% for Ivor-Lewis and 42.7% for McKeown), and the adjusted hazard ratio of overall survival was 1.44 (95% CI, 0.64-3.29; P = 0.381; Ivor-Lewis as the reference). CONCLUSIONS: In our cohort, anastomotic leakage occurred more frequently after McKeown than Ivor-Lewis esophagectomy, and almost half of patients in the McKeown group experienced leakage. Ivor-Lewis esophagectomy is preferred for decreasing anastomotic leakage when oncologically and technically feasible.
Masking Effects Caused by Contralateral Distractors in Participants With Versus Without Listening Difficulties. International-journal

Tetsuaki Kawase, Chie Obuchi, Jun Suzuki, Yukio Katori, Shuichi Sakamoto

Ear and hearing　2024/09/20

DOI： 10.1097/AUD.0000000000001591 　

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OBJECTIVES: To examine the effects of distractor sounds presented to the contralateral ear on speech intelligibility in patients with listening difficulties without apparent peripheral pathology and in control participants. DESIGN: This study examined and analyzed 15 control participants (age range, 22 to 30 years) without any complaints of listening difficulties and 15 patients (age range, 15 to 33 years) diagnosed as having listening difficulties without apparent peripheral pathology in the outpatient clinic of the Department of Otolaryngology-Head and Neck Surgery, Tohoku University Hospital. Speech intelligibility for 50 Japanese monosyllables presented to the right ear was examined under the following three different conditions: "without contralateral sound," "with continuous white noise in the contralateral ear," and "with music stimuli in the contralateral ear." RESULTS: The results indicated the following: (1) speech intelligibility was significantly worse in the patient group with contralateral music stimuli and noise stimuli; (2) speech intelligibility was significantly worse with contralateral music stimuli than with contralateral noise stimuli in the patient group; (3) there was no significant difference in speech intelligibility among three contralateral masking conditions (without contra-stimuli, with contra-noise, and with contra-music) in the control group, although average and median values of speech intelligibility tended to be worse with contralateral music stimuli than without contralateral stimuli. CONCLUSIONS: Significantly larger masking effects due to a contralateral distractor sound observed in patients with listening difficulties without apparent peripheral pathology may suggest the possible involvement of masking mechanisms other than the energetic masking mechanism occurring in the periphery in these patients. In addition, it was also shown that the masking effect is more pronounced with real environmental sounds, that is, music with lyrics, than with continuous steady noise, which is often used as a masker for speech-in-noise testing in clinical trials. In other words, it should be noted that a speech-in-noise test using such steady noise may underestimate the degree of listening problems of patients with listening difficulties in their daily lives, and a speech-in-noise test using a masker such as music and/or speech sounds could make listening problems more obvious in patients with listening difficulties.
A nationwide survey on the safety of cricothyrotomy: a multicenter retrospective study in Japan.

Eisuke Booka, Hiroya Takeuchi, Hirotoshi Kikuchi, Akinori Miura, Mitsuro Kanda, Yoshihiko Kawaguchi, Yoichi Hamai, Motomi Nasu, Shinsuke Sato, Masazumi Inoue, Keisuke Okubo, Ryo Ogawa, Hiroshi Sato, Shigefumi Yoshino, Katsushi Takebayashi, Koji Kono, Yasushi Toh, Yukio Katori

Esophagus : official journal of the Japan Esophageal Society　2024/09/06

DOI： 10.1007/s10388-024-01082-8 　

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BACKGROUND: Cricothyrotomy is a widely performed potentially life-saving treatment to secure an airway in emergencies. It is also a pneumonia-preventing treatment to secure an expectorant route in patients with difficulty self-expelling sputum; however, its safety and usefulness remain unclear. Thus, we conducted a nationwide survey of cricothyrotomy. METHODS: We retrospectively collected and analyzed cricothyrotomy data from the institutions certified by the Japan Broncho-Esophagological Society or the Japanese Esophageal Society. Ultimately, 116 facilities responded to the survey and the present study included 1001 patients from 26 facilities who underwent cricothyrotomies from January 1, 2010 to December 31, 2021. RESULTS: Cricothyrotomy was performed for sputum suctioning after esophagectomy or other surgical procedures in 945 (94.4%) cases and for emergency airway clearance in 48 (4.8%) cases. Complications during puncture were observed in 12 (1.2%) cases. We found significantly fewer complications during puncture for sputum suction (1.0%) compared with emergency airway clearance (4.2%) (p = 0.002), and also at the condition after esophagectomy (0.5%) compared with other surgical procedures (7.8%) (p < 0.001). Complications after puncture were observed in 45 (4.5%) cases, and we found significantly fewer complications after puncture at the condition after esophagectomy (4.2%) compared with other surgical procedures (11.8%) (p = 0.032). There were no significant differences in the type of kit used for complications during and after the puncture. CONCLUSIONS: Cricothyrotomy for prophylactic sputum suctioning after esophagectomy was safer compared to emergency airway clearance. However, future studies should verify the efficacy of cricothyrotomy.
Vestibular paroxysmia caused by a subarcuate artery: illustrative case

Kensuke Sakaji, Shunsuke Omodaka, Masayuki Kanamori, Shunsuke Takai, Akari Sawada, Jun Suzuki, Yukio Katori, Hidenori Endo

Journal of Neurosurgery: Case Lessons　8　(10)　2024/09/02
Publisher: Journal of Neurosurgery Publishing Group (JNSPG)
DOI： 10.3171/case24239 　

eISSN： 2694-1902

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BACKGROUND Vestibular paroxysmia is defined by spontaneous, recurrent, short, paroxysmal episodes of vertigo. The authors present a case of vestibular paroxysmia caused by neurovascular compression of the vestibulocochlear nerve due to the subarcuate artery, which was successfully treated with microvascular decompression. OBSERVATIONS A 46-year-old man ﬁrst experienced vertigo attacks 5 years earlier. The attacks became more frequent, and left-sided tinnitus developed over the past 4 months, prompting a referral to our hospital. Carbamazepine treatment alleviated symptoms but had to be discontinued due to rash. Brain magnetic resonance imaging and angiography revealed that the left anterior inferior cerebellar artery was pressing on the cisternal segment of the left vestibulocochlear nerve. The authors diagnosed vestibular paroxysmia caused by neurovascular compression and performed microvascular decompression. During the operation, a subarcuate artery was identified as the offending vessel, with a prominent indentation on the vestibulocochlear nerve. The vertigo was completely relieved following surgery. LESSONS Neurovascular compression of the vestibulocochlear nerve by the subarcuate artery can result in vestibular paroxysmia. https://thejns.org/doi/abs/10.3171/CASE24239
Anti-CD44 Variant 10 Monoclonal Antibody Exerts Antitumor Activity in Mouse Xenograft Models of Oral Squamous Cell Carcinomas. International-journal

Kenichiro Ishikawa, Hiroyuki Suzuki, Tomokazu Ohishi, Guanjie Li, Tomohiro Tanaka, Manabu Kawada, Akira Ohkoshi, Mika K Kaneko, Yukio Katori, Yukinari Kato

International journal of molecular sciences　25　(17)　2024/08/24

DOI： 10.3390/ijms25179190 　

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CD44 regulates cell adhesion, proliferation, survival, and stemness and has been considered a tumor therapy target. CD44 possesses the shortest CD44 standard (CD44s) and a variety of CD44 variant (CD44v) isoforms. Since the expression of CD44v is restricted in epithelial cells and carcinomas compared to CD44s, CD44v has been considered a promising target for monoclonal antibody (mAb) therapy. We previously developed an anti-CD44v10 mAb, C44Mab-18 (IgM, kappa), to recognize the variant exon 10-encoded region. In the present study, a mouse IgG2a version of C44Mab-18 (C44Mab-18-mG2a) was generated to evaluate the antitumor activities against CD44-positive cells compared with the previously established anti-pan CD44 mAb, C44Mab-46-mG2a. C44Mab-18-mG2a exhibited higher reactivity compared with C44Mab-46-mG2a to CD44v3-10-overexpressed CHO-K1 (CHO/CD44v3-10) and oral squamous cell carcinoma cell lines (HSC-2 and SAS) in flow cytometry. C44Mab-18-mG2a exerted a superior antibody-dependent cellular cytotoxicity (ADCC) against CHO/CD44v3-10. In contrast, C44Mab-46-mG2a showed a superior complement-dependent cytotoxicity (CDC) against CHO/CD44v3-10. A similar tendency was observed in ADCC and CDC against HSC-2 and SAS. Furthermore, administering C44Mab-18-mG2a or C44Mab-46-mG2a significantly suppressed CHO/CD44v3-10, HSC-2, and SAS xenograft tumor growth compared with the control mouse IgG2a. These results indicate that C44Mab-18-mG2a could be a promising therapeutic regimen for CD44v10-positive tumors.
QTc Interval Prolongation as an Adverse Event of Azole Antifungal Drugs: Case Report and Literature Review. International-journal

Shiori Kitaya, Makoto Nakano, Yukio Katori, Satoshi Yasuda, Hajime Kanamori

Microorganisms　12　(8)　2024/08/08

DOI： 10.3390/microorganisms12081619 　

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QTc prolongation and torsade de pointes (TdP) are significant adverse events linked to azole antifungals. Reports on QTc interval prolongation caused by these agents are limited. In this study, we report a case of a 77-year-old male with cardiovascular disease who experienced QTc prolongation and subsequent TdP while being treated with fluconazole for Candida albicans-induced knee arthritis. Additionally, a literature review was conducted on cases where QTc prolongation and TdP were triggered as adverse events of azole antifungal drugs. The case study detailed the patient's experience, whereas the literature review analyzed cases from May 1997 to February 2023, focusing on patient demographics, underlying diseases, antifungal regimens, concurrent medications, QTc changes, and outcomes. The review identified 16 cases, mainly in younger individuals (median age of 29) and women (75%). Fluconazole (63%) and voriconazole (37%) were the most common agents. Concurrent medications were present in 75% of cases, and TdP occurred in 81%. Management typically involved discontinuing or switching antifungals and correcting electrolytes, with all patients surviving. Risk assessment and concurrent medication review are essential before starting azole therapy. High-risk patients require careful electrocardiogram monitoring to prevent arrhythmias. Remote monitoring may enhance safety for patients with implanted devices. Further studies are needed to understand risk factors and management strategies.
Delta-6 desaturase FADS2 is a tumor-promoting factor in cholangiocarcinoma. International-journal Peer-reviewed

Kohsei Hasegawa, Haruna Fujimori, Kohta Nakatani, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Mao Nakamura-Shima, Rie Shibuya-Takahashi, Mai Mochizuki, Yuta Wakui, Makoto Abue, Wataru Iwai, Daisuke Fukushi, Kennichi Satoh, Kazunori Yamaguchi, Norihisa Shindo, Jun Yasuda, Naoki Asano, Takayuki Imai, Yukinori Asada, Yukio Katori, Keiichi Tamai

Cancer science　2024/08/07

DOI： 10.1111/cas.16306 　

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Cholangiocarcinoma is a fatal disease with limited therapeutic options. We screened genes required for cholangiocarcinoma tumorigenicity and identified FADS2, a delta-6 desaturase. FADS2 depletion reduced in vivo tumorigenicity and cell proliferation. In clinical samples, FADS2 was expressed in cancer cells but not in stromal cells. FADS2 inhibition also reduced the migration and sphere-forming ability of cells and increased apoptotic cell death and ferroptosis markers. Lipidome assay revealed that triglyceride and cholesterol ester levels were decreased in FADS2-knockdown cells. The oxygen consumption ratio was also decreased in FADS2-depleted cells. These data indicate that FADS2 depletion causes a reduction in lipid levels, resulting in decrease of energy production and attenuation of cancer cell malignancy.
Supersulfide formation in the sinus mucosa of chronic rhinosinusitis. International-journal Peer-reviewed

Jun Suzuki, Tomotaka Hemmi, Tomoaki Ida, Seiryo Ogata, Jun Yoshitake, Tetsuro Matsunaga, Tomoyasu Ishida, Yuki Numano, Yusuke Kusano, Ryoukichi Ikeda, Kazuhiro Nomura, Mitsuru Sugawara, Nobuo Ohta, Takaaki Akaike, Yukio Katori

Laryngoscope investigative otolaryngology　9　(4)　e1261　2024/08

DOI： 10.1002/lio2.1261 　

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OBJECTIVES: Disruption of the oxidative stress defense system is involved in developing various diseases. Sulfur compounds such as glutathione (GSH) and cysteine (CysSH) are representative antioxidants in the body. Recently, supersulfides, including reactive persulfide and polysulfide species, have gained attention as potent antioxidants regulating oxidative stress and redox signaling. However, their involvement in the pathogenesis of chronic rhinosinusitis (CRS) remains unclear. METHODS: To clarify the changes in sulfur compounds within the sinus mucosa of each CRS subtype, we measured sulfur compound levels in the sinus mucosa of control individuals (n = 9), patients with eosinophilic CRS (ECRS) (n = 13), and those with non-ECRS (nECRS) (n = 11) who underwent sinus surgery using mass spectrometry. RESULTS: GSH and CysSH levels were significantly reduced, and the glutathione disulfide (GSSG)/GSH ratio, an oxidative stress indicator, was increased in patients with ECRS. Despite the absence of notable variations in supersulfides, patients with ECRS and nECRS exhibited a significant reduction in glutathione trisulfide (GSSSG), which serves as the precursor for supersulfides. CONCLUSIONS: This study is the first quantitative assessment of supersulfides in normal and inflamed sinus mucosa, suggesting that sulfur compounds contribute to the pathogenesis of CRS. LEVEL OF EVIDENCE: N/A.
Expression of Vascular and Tissue Repair Factors in Laryngeal Granulomas.

Yutaka Tateda, Ryoukichi Ikeda, Risako Kakuta, Kenji Izuhara, Takenori Ogawa, Kazue Ise, Hiroki Shimada, Keigo Murakami, Kazuhiro Murakami, Yasuhiro Nakamura, Yukio Katori, Nobuo Ohta

The Tohoku journal of experimental medicine　2024/06/27

DOI： 10.1620/tjem.2024.J056 　
Treatment of elderly patients with head and neck cancer in an aging society: Focus on geriatric assessment and surgical treatment. International-journal

Ryo Ishii, Akira Ohkoshi, Yukio Katori

Auris, nasus, larynx　51　(4)　647-658　2024/04/16

DOI： 10.1016/j.anl.2024.04.005 　

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Previous studies of the treatment of elderly head and neck cancer (HNC) patients were very limited and sometimes controversial. Although conclusions differ across various reports, it is often concluded that advanced chronological age does not directly affect prognosis, but that comorbidities and declines in physical and cognitive functions promote the occurrence of adverse events, especially with surgical treatment. Geriatric assessment (GA) and its screening tools are keys to help us understand overall health status and problems, predict life expectancy and treatment tolerance, and to influence treatment choices and interventions to improve treatment compliance. In addition, personal beliefs and values play a large role in determining policies for HNC treatment for elderly patients, and a multidisciplinary approach is important to support this. In this review, past research on HNC in older adults is presented, and the current evidence is explained, focusing on the management of elderly HNC patients, with an emphasis on the existing reports on each treatment stage and modality, especially the surgical procedures.
Cochlear aqueduct revisited: A histological study using human fetuses. International-journal

Kwang Ho Cho, Ji Hyun Kim, Yohei Honkura, Masahito Yamamoto, Gen Murakami, Jose Francisco Rodríguez-Vázquez, Yukio Katori

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft　253　152236-152236　2024/04

DOI： 10.1016/j.aanat.2024.152236 　

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BACKGROUND AND AIM: The cochlear aqueduct (CA) connects between the perilymphatic space of the cochlea and the subarachnoid space in the posterior cranial fossa. The study aimed to examine 1) whether cavitation of the CA occurs on the subarachnoid side or the cochlear side and 2) the growth and/or degeneration of the CA and its concomitant vein. METHODS: We examined paraffin-embedded histological sections from human fetuses: 15 midterm fetuses (crown-rump length or CRL, 39-115 mm) and 12 near-term fetuses (CRL, 225-328 mm). RESULTS: A linear mesenchymal condensation, i.e., a likely candidate of the CA anlage, was observed without the accompanying vein at 9-10 weeks. The vein appeared until 15 weeks, but it was sometimes distant from the CA. At 10-12 weeks, the subarachnoid space (or the epidural space) near the glossopharyngeal nerve rapidly protruded into the CA anlage and reached the scala tympani, in which cavitation was gradually on-going but without epithelial lining. However, CA cavitation did not to occur in the anlage. At the opening to the scala, the epithelial-like lining of the CA lost its meningeal structure. At near-term, the CA was often narrowed and obliterated. CONCLUSION: The CA develops from meningeal tissues when the cavitation of the scala begins. The latter cavitation seemed to reduce tissue stiffness leading, to meningeal protrusion. The so-called anlage of CA might be a phylogenetic remnant of the glossopharyngeal nerve branch. A course of cochlear veins appears to be determined by a rule different from the CA development.
Effect of wearing masks on odor detection and recognition. International-journal

Taiga Kato, Jun Suzuki, Yuta Kobayashi, Tetsuya Oishi, Hiroyuki Ikushima, Yasunari Yamauchi, Yukio Katori

Acta oto-laryngologica　144　(2)　142-146　2024/02

DOI： 10.1080/00016489.2024.2325047 　

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BACKGROUND: The effect of wearing masks on olfaction remains unclear. OBJECTIVES: This study aimed to clarify the differences between the effects of no masks, surgical masks, and N95 respirator masks by conducting both identification and threshold olfaction tests. METHODS: Young, healthy volunteers aged ≥ 18 years and < 30 years without awareness of apparent olfactory disorder were included. All participants filled out a questionnaire on olfaction and completed an acuity smell identification test (Open Essence test) and an olfactory threshold test (T&T olfactometry) while wearing no masks, surgical masks, or N95 respirator masks. RESULTS: In the Open Essence tests, the no-mask group score was significantly higher than those of the surgical- and N95-mask groups. Using T&T olfactometry, the median-detection threshold of the no-mask group was significantly lower than that of the surgical-mask group, and the surgical-mask group threshold was significantly lower than that of the N95-mask group. Similar patterns were observed for the median-recognition threshold. CONCLUSIONS: Wearing masks, especially an N95 mask, reduces the ability to detect and identify odors. This disadvantage should be considered by professionals such as healthcare workers, who require proper olfaction to perform appropriate tasks.
Type 2 Diabetes Mellitus is a Risk Factor for Skeletal Muscle Loss in the Course of Dietary Treatment for Patients with Metabolic Dysfunction-associated Steatotic Liver Disease

Akitoshi Sano, Manami Sasaki, Jun Inoue, Eiji Kakazu, Masashi Ninomiya, Mio Tsuruoka, Kosuke Sato, Masazumi Onuki, Satoko Sawahashi, Keishi Ouchi, Kotaro Doi, Yukio Katori, Atsushi Masamune

Internal Medicine　2024
Publisher: Japanese Society of Internal Medicine
DOI： 10.2169/internalmedicine.3787-24 　

ISSN： 0918-2918

eISSN： 1349-7235

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Objective This study assessed the impact of dietary therapy and reduced body weight on the loss of skeletal muscle in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). Methods This was a single-center retrospective observational study. We enrolled 129 patients with MASLD who had undergone dietary therapy at our facility. We assessed skeletal muscle mass using a bioelectrical impedance analysis (BIA) at the start of dietary treatment and 12 months after the first assessment. Variables related to muscle reduction were analyzed using a logistic regression model. Results One hundred and eighteen cases were analyzed, excluding those with missing data. In the muscle reduction group, there were more subjects with body weight reduction than in the control group (68% and 40%, respectively, p =0.002), and their body mass index (BMI) was decreased (-0.7 kg/m2 and +0.3 kg/m2, respectively, p =0.0003). There was a significant correlation between the changes in the BMI and muscle mass (R =0.48, p <0.0001). We standardized muscle mass change by dividing it by weight change to analyze the severe decrease in muscle mass compared to weight change. A logistic regression analysis revealed that type 2 diabetes mellitus (T2DM) was an independent variable related to severe skeletal muscle loss (odds ratio, 2.69; 95% CI: 1.13-6.42, p =0.03). Conclusion Weight loss is associated with skeletal muscle loss during dietary treatment for MASLD. T2DM is a risk factor for severe skeletal muscle loss.
Breathing-Swallowing discoordination after definitive chemoradiotherapy for head and neck cancers is associated with aspiration pneumonia. International-journal

Takuya Yoshida, Naomi Yagi, Takenori Ogawa, Ayako Nakanome, Akira Ohkoshi, Yukio Katori, Yoshitaka Oku

PloS one　19　(7)　e0305560　2024

DOI： 10.1371/journal.pone.0305560 　

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PURPOSE: Swallowing dysfunction and the risk of aspiration pneumonia are frequent clinical problems in the treatment of head and neck squamous cell carcinomas (HNSCCs). Breathing-swallowing coordination is an important factor in evaluating the risk of aspiration pneumonia. To investigate breathing-swallowing discoordination after chemoradiotherapy (CRT), we monitored respiration and swallowing activity before and after CRT in patients with HNSCCs. METHODS: Non-invasive swallowing monitoring was prospectively performed in 25 patients with HNSCCs treated with CRT and grade 1 or lower radiation-induced dermatitis. Videoendoscopy, videofluoroscopy, Food Intake LEVEL Scale, and patient-reported swallowing difficulties were assessed. RESULTS: Of the 25 patients selected for this study, four dropped out due to radiation-induced dermatitis. The remaining 21 patients were analyzed using a monitoring system before and after CRT. For each of the 21 patients, 405 swallows were analyzed. Swallowing latency and pause duration after the CRT were significantly extended compared to those before the CRT. In the analysis of each swallowing pattern, swallowing immediately followed by inspiration (SW-I pattern), reflecting breathing-swallowing discoordination, was observed more frequently after CRT (p = 0.0001). In 11 patients, the SW-I pattern was observed more frequently compared to that before the CRT (p = 0.00139). One patient developed aspiration pneumonia at 12 and 23 months after the CRT. CONCLUSION: The results of this preliminary study indicate that breathing-swallowing discoordination tends to increase after CRT and could be involved in aspiration pneumonia. This non-invasive method may be useful for screening swallowing dysfunction and its potential risks.
Clinical characteristics and outcomes of persistent bacteremia in patients with head and neck cancer in a tertiary care hospital. International-journal

Shiori Kitaya, Hajime Kanamori, Ryo Ishii, Makoto Katsumi, Ryoukichi Ikeda, Kenjiro Higashi, Risako Kakuta, Akira Ohkoshi, Yukio Katori

Frontiers in medicine　11　1406983-1406983　2024

DOI： 10.3389/fmed.2024.1406983 　

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INTRODUCTION: Compared to other cancers, research on bloodstream infection in head and neck cancer is scarce, lacking comparative studies on persistent versus transient bacteremia outcomes. METHODS: This retrospective survey examined patients with head and neck cancer undergoing blood culture at our center from June 2009 to May 2023. Blood culture-positive cases suspected of infection were divided into persistent bacteremia and transient bacteremia groups. We investigated their clinical, epidemiological, and microbiological features, including risk factors for persistent bacteremia and mortality. The primary outcome was 90-day mortality. RESULTS: In this 97-patient cohort, 14 (14%) cases were assigned to the persistent bacteremia group. Catheter-related bloodstream infections were the leading cause of infection in both groups, consistently contributing to a high proportion of overall bloodstream infections. The mortality rate was generally higher in the persistent bacteremia group than in the transient bacteremia group (odds ratio [OR], 2.6; 95% confidence interval [CI], 0.6-11.1), particularly in the non-clearance subgroup (OR, 9; 95% CI, 0.5-155.2). Pyogenic spondylitis was a key risk factor for persistent bacteremia, while hypoalbuminemia increased mortality. CONCLUSION: In patients with bacteremia and head and neck cancer, persistent bacteremia was associated with higher mortality than was transient bacteremia. Adittionally, bacteremia clearance in persistent bacteremia is thus crucial for prognostic improvement.
Epidemiology of postoperative bleeding after endoscopic nasal and sinus surgery and factors associated with bleeding. International-journal Peer-reviewed

Tomotaka Hemmi, Kazuhiro Nomura, Yuta Kobayashi, Yuki Numano, Ryoukichi Ikeda, Mitsuru Sugawara, Yukio Katori

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery　2023/12/12

DOI： 10.1007/s00405-023-08377-z 　

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PURPOSE: Endoscopic nasal and sinus surgery is a surgical procedure frequently performed by otolaryngologists. Postoperative bleeding is detrimental to both healthcare providers and patients. We investigated the epidemiology of postoperative bleeding during endoscopic nasal and sinus surgery and explored possible bleeding triggers. METHODS: We evaluated the patients who underwent endoscopic nasal and sinus surgery. Data regarding the age, sex, presence of hypertension, and abnormal coagulability, including oral anticoagulants, diagnoses, operative procedures, intraoperative use of drills and blood loss, and postoperative antimicrobial administration of eligible patients, were extracted from medical records and retrospectively reviewed. RESULTS: One hundred and eighty-six patients underwent endoscopic nasal or sinus surgery during the study period, and postoperative bleeding occurred in 9 patients (4.8%). Posterior nasal neurotomy (PNN) was the procedure most likely to cause postoperative bleeding (4 surgeries, 13.3%). Postoperative antimicrobial administration significantly reduced the incidence of postoperative bleeding (p = 0.04). CONCLUSIONS: Postoperative bleeding requiring intervention occurs in 4.8% of cases, and PNN is associated with a high risk of postoperative bleeding. Wound infection is a potential cause of postoperative bleeding, and antimicrobial administration should be considered in addition to local treatment.
Immunohistochemical localization of CD31, CD34, and periostin in vocal fold polyps. International-journal

Yutaka Tateda, Teruyuki Sato, Ryoukichi Ikeda, Risako Kakuta, Kenji Izuhara, Takenori Ogawa, Kazue Ise, Hiroki Shimada, Masashi Katoh, Keigo Murakami, Kazuhiro Murakami, Yasuhiro Nakamura, Yukio Katori, Nobuo Ohta

Acta oto-laryngologica　1-8　2023/10/30

DOI： 10.1080/00016489.2023.2263483 　

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BACKGROUND: Long-term voice-abuse or sudden vocal fold microvascular disruption can lead to injury and subsequent repair/remodeling of the vocal fold mucosa. Periostin is known to be involved in airway remodeling and in various otolaryngological diseases. In ischemic heart disease, increased CD31 expression has been observed around cardiomyocytes during remodeling, and endothelial proliferation has been reported to occur at these sites. OBJECTIVES: We investigated the expression and the roles of CD31, CD34, and periostin in the formation of vocal fold polyps. MATERIALS AND METHODS: Fifty-seven samples of vocal fold polyps were investigate histopathologically and immunohistochemically. RESULT: Expression of CD31 and CD34 was detected in 41 (71.9%) and 53 (93.0%) samples, respectively, obtained from patients with vocal fold polyp. Expression of periostin was detected in 41 (71.9%) samples obtained from patients with vocal polyps. The vocal polyp samples could be classified into three histological subtypes. Three patterns of CD31 and CD34 expression were observed in the vocal polyp. Four patterns of periostin expression were observed in vocal polyps. An association was observed between the CD31 expression pattern and the histological subtype of vocal fold polyps. CONCLUSION AND SIGNIFICANCE: In vocal fold polyps, evaluation of vascular endothelial markers may be useful for staging.
Sensorineural Hearing Loss due to Acute Carbon Monoxide Poisoning. International-journal Peer-reviewed

Takuya Endo, Jun Suzuki, Ryoukichi Ikeda, Yukio Katori

The journal of international advanced otology　19　(5)　435-439　2023/10

DOI： 10.5152/iao.2023.231117 　

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Carbon monoxide (CO) can cause "irreversible" severe-to-profound sensorineural hearing loss. However, there are few reports of detailed hearing test results. Here, we report a case of acute sensorineural hearing loss caused by acute CO poisoning with partial hearing recovery, evaluated by a detailed hearing examination. A 25-year-old woman was brought to the emergency department for attempted suicide. On admission, her consciousness was impaired, and she was treated for severe CO poisoning, including using hyperbaric-oxygen therapy. After regaining consciousness, symptoms of hearing loss and tinnitus were discovered, and a detailed audiological examination revealed bilateral hearing loss, suggesting cochlear damage. Steroids were systemically administered, and her hearing impairment was partially resolved. Sensorineural hearing loss caused by acute CO poisoning includes cochlear pathology and may be partially treatable. The early evaluation of hearing in patients with severe CO poisoning is advisable for early treatment.
Impact of palatoplasty techniques on tympanic membrane findings and hearing prognosis in children with cleft palate. International-journal Peer-reviewed

Shiori Kitaya, Jun Suzuki, Ryoukichi Ikeda, Akimitsu Sato, Mika Adachi, Masayuki Shirakura, Yuta Kobayashi, Shiho Shirakura, Yuka Suzuki, Yoshimichi Imai, Yukio Katori

International journal of pediatric otorhinolaryngology　174　111747-111747　2023/09/27

DOI： 10.1016/j.ijporl.2023.111747 　

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OBJECTIVE: Children with cleft palate (CP) are at high risk of developing otitis media with effusion (OME) due to Eustachian tube (ET) dysfunction. Palatoplasty has been reported to decrease the frequency of middle ear disease and improve ET function, and although various techniques have been developed, there is no consensus on the differences in the impact of different techniques on the middle ear. The purpose of this study was to determine the differential effects of palatoplasty on middle ear function and hearing. METHODS: We performed a retrospective observational survey of pediatric patients who underwent palatoplasty for CP between June 2010 and October 2018 at Tohoku University Hospital. Cases were divided into three groups depending on the palatoplasty procedures performed: the push-back palatoplasty group, the two-flap palatoplasty group, and the Furlow double-opposing Z-plasty group. We examined the differences in clinical characteristics between patients who underwent each procedure. The primary outcome variable was tympanic membrane (TM) findings, and the secondary outcome was hearing test results. RESULTS: Children who underwent the two-flap palatoplasty had a higher tympanostomy tube (TT) insertion rate and a higher total number of TT insertions than those who underwent the Furlow double-opposing Z-plasty or the push-back palatoplasty. The TM retraction rate tended to be lower in the Furlow double-opposing Z-plasty group than in the push-back palatoplasty group or the two-flap palatoplasty group. The hearing test results at the last visit were not significantly different among the three groups. CONCLUSIONS: Children who underwent the two-flap palatoplasty had a higher rate of TT insertions, potentially increasing the risk of TM perforation. In contrast, the Furlow double-opposing Z-plasty group had a lower tendency for TM regression, possibly due to improved ET function and reduced incidence of OME. It is important to understand the advantages and disadvantages of each technique before selecting one suitable for the child's cleft and arch width. Additionally, it is important to conduct regular follow-up of TM findings and hearing test results even after palatoplasty.
Salmonella Enteritidis ST11 Prosthetic Valve Endocarditis Complicated by a Paravalvular Abscess: Case Report and Literature Review Peer-reviewed

Shiori Kitaya, Shintaro Katahira, Hiroaki Baba, Yoshikatsu Saiki, Yukio Katori, Koichi Tokuda, Hajime Kanamori

Applied Microbiology　3　(3)　1057-1067　2023/09/08
Publisher: MDPI AG
DOI： 10.3390/applmicrobiol3030073 　

eISSN： 2673-8007

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Salmonella infection typically causes self-limiting gastroenteritis. However, in rare cases, it can lead to prosthetic valve endocarditis (PVE), especially in older adults with a history of valve replacement surgery. In this case study, we describe a case of Salmonella PVE in a man with a prosthetic aortic valve. Complications of PVE include abscess formation, which is associated with increased mortality. If a patient with a history of prosthetic valve replacement presents with symptoms suggestive of gastroenteritis or bacteremia, a thorough investigation should be conducted with suspicion of PVE. The prognosis of Salmonella PVE can be improved by promptly initiating appropriate antibiotics and administering them for an adequate duration, as well as by considering surgical intervention when necessary. Additionally, confirming negative blood cultures after treatment of Salmonella bacteremia is important to prevent the development of PVE and paravalvular abscesses.
Long-term voice evaluation after arytenoid adduction surgery in patients with unilateral vocal fold paralysis. International-journal Peer-reviewed

Kenichi Watanabe, Ai Hirano, Yuta Kobayashi, Takeshi Sato, Yohei Honkura, Yukio Katori

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery　2023/08/16

DOI： 10.1007/s00405-023-08165-9 　

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PURPOSE: Laryngeal framework surgery, including medialization laryngoplasty and arytenoid adduction (AA), is expected to have a lasting or permanent effect in patients with unilateral vocal fold paralysis (UVFP); however, there are few reports about the long-term outcomes of AA. This study aimed to evaluate the long-term postoperative effects of AA surgery and examine its stability and reliability. METHODS: This study collected the voice handicap index (VHI) questionnaire from patients with UVFP who underwent AA more than 2 years previously. The VHI values preoperatively and 3 months postoperatively (early postoperative evaluation) were retrospectively calculated, and VHI values more than 2 years after surgery (late postoperative evaluation) were collected by mailing a sheet to the patients and asking to fill and return it. Possible influenced subscales such as age, sex, causes of UVFP, affected side, and surgeons were also analyzed. RESULTS: A total of 77 patients with UVFP who underwent AA had significantly lower early and late postoperative evaluations than preoperative evaluations. In 38 patients with no missing values, there were no significant differences between early and late postoperative evaluations, measured at a median of approximately 5 years. There were also no significant differences between early and late postoperative evaluations in any of the subscale groups. CONCLUSION: Patients with UVFP who underwent AA surgery achieved stable voice improvement in the long term after surgery.
The Transition of Pediatric Tracheobronchial Foreign Body Cases in the Past 36 Years: A Retrospective Single-Center Study in Japan. Peer-reviewed

Hiyori Takahashi, Jun Suzuki, Ryoukichi Ikeda, Tetsuya Oishi, Jun Ohta, Ai Hirano-Kawamoto, Yukio Katori

The Tohoku journal of experimental medicine　2023/08/03

DOI： 10.1620/tjem.2023.J062 　
Effects of zinc deficiency on the regeneration of olfactory epithelium in mice. International-journal Peer-reviewed

Hiroyuki Ikushima, Jun Suzuki, Tomotaka Hemmi, Ryoukichi Ikeda, Yuta Kobayashi, Nobuo Ohta, Yukio Katori

Chemical senses　48　2023/08/01

DOI： 10.1093/chemse/bjad023 　

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The olfactory epithelium can regenerate after damage; however, the regeneration process is affected by various factors, such as viral infections, head trauma, and medications. Zinc is an essential trace element that has important roles in organ development, growth, and maturation. Zinc also helps regulate neurotransmission in the brain; nevertheless, its relationship with olfactory epithelium regeneration remains unclear. Therefore, we used a severe zinc deficiency mouse model to investigate the effects of zinc deficiency on olfactory epithelium regeneration. Male wild-type C57BL/6 mice were divided into zinc-deficient and control diet groups at the age of 4 weeks, and methimazole was administered at the age of 8 weeks to induce severe olfactory epithelium damage. We evaluated the olfactory epithelium before and 7, 14, and 28 d after methimazole administration by histologically analyzing paraffin sections. RNA sequencing was also performed at the age of 8 weeks before methimazole administration to examine changes in gene expression caused by zinc deficiency. In the zinc-deficient group, the regenerated olfactory epithelium thickness was decreased at all time points, and the numbers of Ki-67-positive, GAP43-positive, and olfactory marker protein-positive cells (i.e., proliferating cells, immature olfactory neurons, and mature olfactory neurons, respectively) failed to increase at some time points. Additionally, RNA sequencing revealed several changes in gene expression, such as a decrease in the expression of extracellular matrix-related genes and an increase in that of inflammatory response-related genes, in the zinc-deficient group. Therefore, zinc deficiency delays olfactory epithelium regeneration after damage in mice.
A Preoperative Imaging Evaluation to Avoid Orbital Complications in Functional Endoscopic Sinus Surgery. International-journal Peer-reviewed

Tomotaka Hemmi, Kazuhiro Nomura, Yuta Kobayashi, Yuki Numano, Jun Suzuki, Mitsuru Sugawara, Yukio Katori

The Journal of craniofacial surgery　34　(6)　e598-e600　2023/06/15

DOI： 10.1097/SCS.0000000000009496 　

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Functional endoscopic sinus surgery has become popular worldwide. However, serious complications have been reported with it. A preoperative imaging evaluation is thus essential to avoid complications. The authors compared 0.5 mm slice computed tomography (CT) images reconstructed from sinus CT data with conventional 2 mm slice CT images. The authors evaluated patients who underwent endoscopic surgery. Data regarding age, sex, history of craniofacial trauma, diagnosis, operative procedure, and CT findings of eligible patients were extracted from medical records and retrospectively reviewed. One hundred twelve patients underwent endoscopic surgery during the study period. Six patients (5.4%) had orbital blowout fractures, and half of them could only be identified by 0.5 mm slice CT images. The authors presented the usefulness of 0.5 mm slice CT images in the preoperative imaging evaluation of functional endoscopic sinus surgery. Surgeons should also recognize that a small number of patients have "stealth" (asymptomatic and unrecognized) blowout fractures.
Characteristic findings in the human fetus vestibule: A human temporal bone study. International-journal Peer-reviewed

Yohei Honkura, Yukio Katori, Ai Hirano-Kawamoto, Tetsuaki Kawase, Jose Francisco Rodríguez-Vázquez, Gen Murakami, Hiroshi Abe

Auris, nasus, larynx　2023/06/10

DOI： 10.1016/j.anl.2023.05.004 　

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OBJECTIVE: The "collapse," a highly flexed, dented, or caved membrane between the endo- and peri-lymph of the saccule and utricle in adults, is considered as a morphological aspect of Ménière's syndrome. Likewise, when mesh-like tissues in the perilymphatic space are damaged or lost, the endothelium loses mechanical support and causes nerve irritation. However, these morphologies were not examined in fetuses. METHODS: By using histological sections from 25 human fetuses (crown-rump length[CRL] 82-372 mm; approximately 12-40 weeks), morphologies of the perilymphatic-endolymphatic border membrane and the mesh-like tissue around the endothelium were examined. RESULTS: The highly flexed or caved membrane between the endo- and peri-lymphatic spaces was usually seen in the growing saccule and utricle of fetuses, especially at junctions between the utricle and ampulla at midterm. Likewise, the perilymphatic space around the saccule, utricle and semicircular ducts often lost the mesh-like tissues. The residual mesh-like tissue supported the veins, especially in the semicircular canal. CONCLUSION: Within a cartilaginous or bony room showing a limited growth in size but containing increased perilymph, the growing endothelium appeared to become wavy. Owing to a difference in growth rates between the utricle and semicircular duct, the dentation tended to be more frequently seen at junctions than at free margins of the utricle. The difference in site and gestational age suggested that the deformity was not "pathological" but occurred due to unbalanced growth of the border membrane. Nevertheless, the possibility that the deformed membrane in fetuses was an artifact caused by delayed fixation is not deniable.
Salivary gland cancer organoids are valid for preclinical genotype-oriented medical precision trials. International-journal Peer-reviewed

Tomohiko Ishikawa, Takenori Ogawa, Masahiro Shiihara, Hajime Usubuchi, Yuko Omori, Katsuya Hirose, Taito Itoh, Takuya Yoshida, Ayako Nakanome, Akira Okoshi, Kenjiro Higashi, Ryo Ishii, Masahiro Rokugo, Shun Wakamori, Yasunobu Okamura, Kengo Kinoshita, Yukio Katori, Toru Furukawa

iScience　26　(5)　106695-106695　2023/05/19

DOI： 10.1016/j.isci.2023.106695 　

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Salivary gland cancers (SGCs) are heterogeneous tumors, and precision oncology represents a promising therapeutic approach; however, its impact on SGCs remains obscure. This study aimed to establish a translational model for testing molecular-targeted therapies by combining patient-derived organoids and genomic analyses of SGCs. We enrolled 29 patients, including 24 with SGCs and 5 with benign tumors. Resected tumors were subjected to organoid and monolayer cultures, as well as whole-exome sequencing. Organoid and monolayer cultures of SGCs were successfully established in 70.8% and 62.5% of cases, respectively. Organoids retained most histopathological and genetic profiles of their original tumors. In contrast, 40% of the monolayer-cultured cells did not harbor somatic mutations of their original tumors. The efficacy of molecular-targeted drugs tested on organoids depended on their oncogenic features. Organoids recapitulated the primary tumors and were useful for testing genotype-oriented molecular targeted therapy, which is valuable for precision medicine in patients with SGCs.
Immunohistochemical Localization of D-β-Aspartic Acid and Periostin in Vocal Fold Polyps. Peer-reviewed

Yutaka Tateda, Ryoukichi Ikeda, Risako Kakuta, Kenji Izuhara, Takenori Ogawa, Kazue Ise, Hiroki Shimada, Keigo Murakami, Kazuhiro Murakami, Yasuhiro Nakamura, Yukio Katori, Nobuo Ohta

The Tohoku journal of experimental medicine　260　(3)　223-230　2023/04/27

DOI： 10.1620/tjem.2023.J035 　

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Long-term voice abuse or sudden vocal fold microvascular disruption may lead to injury and subsequent repair/remodeling in the vocal fold mucosa. Periostin is known to be involved in airway remodeling and also in various otolaryngological diseases. D-β-aspartic acid is the major isomer of D-aspartic acid found in elderly tissue. In this study we investigated the expression and the role of D-β-aspartic acid and periostin in the formation of vocal fold polyps. The expression patterns of D-β-aspartic acid and periostin in 36 surgical specimens of vocal fold polyps from 36 patients were investigated immunohistochemically. In the epithelium of vocal polyps, D-β-aspartic acid was expressed in all cases. Expression of D-β-aspartic acid was detected in 25 samples obtained from patients with vocal fold polyps stroma. Expression of periostin was detected in 28 samples obtained from patients with vocal fold polyps. Two patterns of D-β-aspartic acid expression were observed in vocal fold polyps stroma: positive type and negative type. The following four patterns of periostin expression were observed in vocal fold polyps: negative type, superficial type, infiltrative type, and diffuse type. An association was observed between D-β-aspartic acid expression patterns and periostin expression patterns. From these findings we speculate that periostin and D-β-aspartic acid participate in certain pathological changes in vocal fold polyps, such as extracellular matrix accumulation, local fibrosis, and the formation and development of vocal fold polyps.
Clinical Features and Outcomes of Persistent Candidemia Caused by Candida albicans versus Non-albicans Candida Species: A Focus on Antifungal Resistance and Follow-Up Blood Cultures. International-journal Peer-reviewed

Shiori Kitaya, Hajime Kanamori, Yukio Katori, Koichi Tokuda

Microorganisms　11　(4)　928　2023/04/03

DOI： 10.3390/microorganisms11040928 　

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The clinical distinctions among variations in Candida species, antifungal resistance (AFR), and clearance status of hospital-acquired persistent candidemia (HA-PC) remain uncertain. This secondary analysis of a retrospective cohort study aimed to assess the differences in HA-PC based on different Candida species, AFR, and persistent candidemia (PC) clearance status. A retrospective review was conducted using medical records from Tohoku University Hospital of patients for whom blood cultures were performed between January 2012 and December 2021. PC cases were categorized into groups based on Candida species, azole, or echinocandin resistance, as well as PC-clearance status, and the respective characteristics were analyzed. The HA-PC non-clearance group had a tendency toward higher 30-90-day and 90-day mortality rates compared to the HA-PC-clearance group in both the susceptible and resistant strain groups, with the former group demonstrating a statistically significant difference (odds ratio = 19, p = 0.028). The high mortality rate observed in the Candida non-albicans and resistant strain groups necessitates a more meticulous therapeutic management approach for PC. Follow-up blood cultures and confirmation of PC clearance are useful for improving the survival rates of both the HA-PC-susceptible and -resistant strain groups.
Nasal capsule ossification: A histological study using human foetuses to find an association between the foetus and adult morphologies of the nasal wall International-journal International-coauthorship Peer-reviewed

Masahito Yamamoto, Shogo Hayashi, Yohei Honkura, Ai Hirano‐Kawamoto, Yukio Katori, Gen Murakami, José Francisco Rodríguez‐Vázquez, Shinichi Abe

Journal of Anatomy　243　(3)　517-533　2023/03/30
Publisher: Wiley
DOI： 10.1111/joa.13867 　

ISSN： 0021-8782

eISSN： 1469-7580

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Recent molecular biology studies have revealed the process of nasal capsule determination. We aimed to create a fate map showing the association between the adult and embryonic components of the nasal wall and nasal capsule derivatives. We examined paraffin-embedded histological sections between 15 mid-term (9–16 weeks) and 12 near-term (27–40 weeks) foetuses. Until 15 weeks, membranous ossification occurred ‘along’ the capsular cartilage, contributing to the formation of the vomer, maxilla and bony nasal septum as well as the nasal, frontal and lacrimal bones. After 15 weeks, a wide lateral part of the capsule became thin and fragmented, and degenerative cartilage was observed near the lacrimal bone, in the three conchae, and at the inferolateral end of the capsule sandwiched between the maxilla and palatine bone. The disappearing cartilages appeared to be replaced by nearby membranous bones. This type of membranous ossification did not appear to use the capsular cartilage as a ‘mould’, although the perichondrium may have a role in inducing ossification. Calcified cartilage indicated endochondral ossification in the inferior concha until 15 weeks and, later, at the bases of three conchae and around the future sphenoid sinus (i.e. the concha sphenoidalis). The capsular cartilage extended antero-superiorly over the frontal bone and inserted into the nasal bone. At 40 weeks, the capsular cartilage remained in the cribriform plate and at the inferolateral end along the palatine bone. Consequently, less guidance from the nasal capsule seemed to provide great individual variation in the shape of the wide anterolateral wall of the nasal cavity.
Tympanic membrane findings and Eustachian tube function after transtympanic plugging for the chronic patulous Eustachian tube. International-journal Peer-reviewed

Yusuke Kusano, Ryoukichi Ikeda, Yoshinobu Kawamura, Hidetoshi Oshima, Yuri Nomura, Toshiaki Kikuchi, Tetsuaki Kawase, Yukio Katori, Toshimitsu Kobayashi

Auris, nasus, larynx　2023/03/29

DOI： 10.1016/j.anl.2023.03.007 　

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OBJECTIVE: To evaluate Eustachian tube (ET) function after Kobayashi plug surgery based on the tympanic membrane (TM) findings and active opening (AO) of the ET assessed with sonotubometry. SUBJECTS AND METHODS: A retrospective survey of medical records identified 74 ears of 66 patients with patulous ET (PET) received transtympanic insertion of the Kobayashi plug. Excluding the six ears (6 patients) with abnormal preoperative TM, sixty-eight ears of 60 patients were found to have normal TM preoperatively. Among these 68 ears, there were 51 ears in which sonotubometry was performed both before and after surgery to evaluate whether the AO of the ET was positive or not. RESULTS: Out of the 68 ears with normal preoperative TM, 52 ears (76.5%) were judged successful (sum of complete relief and significant improvement). The postoperative TM was normal in 41 ears (60.3%), while 27 ears (39.7%) had abnormal TM findings postoperatively. The success rate was 75.6% (31/41) in ears with normal postoperative TM, while it was 77.8% (21/27) in ears with abnormal TM. Success in maintaining normal postoperative TM was found in 45.6% (31/68) of the total ears treated. Out of the 51 ears in which sonotubometry was performed both before and after surgery, AO was preoperatively positive in 88.2% of the ears (45/51), while it was positive in 64.7% (33/51) postoperatively. In thirty-four ears with normal TM postoperatively, AO was positive in 24 ears (70.6%), while it was positive in 9 out of 17 ears (52.9%) with abnormal postoperative TM. The success rate was 70.6% (36/51) for the 51 ears in which AO was assessed both pre- and postoperatively, and it was 66.7% (22/33) in ears with positive AO postoperatively, while it was 77.8% (14/18) in ears without AO postoperatively. The incidence of ears either having normal postoperative TM or positive AO postoperatively was 84.3% (43/51). Abnormal postoperative TM findings without effectiveness were found in 8.8% (6/68). CONCLUSION: The obstructive dysfunction of the ET is a calculated risk but did not occur in most ears after plugging with the Kobayashi plug. Therefore, routine insertion of the VT at the same time as the initial surgery is not recommended for PET cases that are adequately followed up.
Clinical Characteristics and Outcomes of Persistent Staphylococcal Bacteremia in a Tertiary Care Hospital. International-journal Peer-reviewed

Shiori Kitaya, Hajime Kanamori, Yukio Katori, Koichi Tokuda

Antibiotics (Basel, Switzerland)　12　(3)　2023/02/24

DOI： 10.3390/antibiotics12030454 　

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Clinical outcomes of persistent staphylococcal bacteremia vary depending on the causative organism. This secondary data analysis study compared the clinical characteristics of persistent Staphylococcus aureus (S. aureus)- and coagulase-negative staphylococci (CoNS)-caused bacteremia, focusing on the methicillin-resistant status. This study used data collected from patients who underwent blood cultures between January 2012 and December 2021 at Tohoku University Hospital, Japan. Patients with persistent staphylococcal bacteremia were divided into groups based on the pathogen and methicillin-resistant status, and their characteristics were analyzed. The primary outcomes were early (30-day), late (30-90 days), and 90-day mortality rates. The early, late, and 90-day mortality rates were similar between the persistent CoNS and S. aureus bacteremia groups. Patients with persistent methicillin-resistant S. aureus (MRSA) bacteremia tended to have higher early, late, and 90-day mortality rates than those with persistent methicillin-susceptible S. aureus bacteremia (not statistically significant). No differences were observed between the methicillin-resistant and-susceptible CoNS groups. In patients with persistent CoNS bacteremia, mortality tended to increase, especially in debilitated or immunocompromised patients with distant metastases, underscoring the importance of infection source control. Mortality tended to be high in patients with persistent MRSA bacteremia, especially when persistent bacteremia clearance was not confirmed, illustrating the need for careful therapeutic management.
Effects of Unilateral Vagotomy on LPS-Induced Aspiration Pneumonia in Mice. International-journal Peer-reviewed

Daisuke Tatsushima, Takaomi Kurioka, Kunio Mizutari, Jun Suzuki, Ryoukichi Ikeda, Takuma Hisaoka, Yasutoshi Koshiba, Hiyori Takahashi, Hikaru Hashimoto, Yukio Katori, Akihiro Shiotani

Dysphagia　38　(5)　1353-1362　2023/02/14
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s00455-023-10564-3 　

ISSN： 0179-051X

eISSN： 1432-0460

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Respiratory-related dysphagia and aspiration pneumonia can be attributed to multiple causes. However, reproduction of multiple factor-related respiratory distress and aspiration pneumonia in a single animal model is challenging. To validate animals with vagal nerve palsy as novel models for severe aspiration pneumonia associated with respiratory distress, we investigated the effects of unilateral vagotomy on the swallowing function and severity of pneumonia after forced aspiration in mice. Unilateral vagotomy was performed in C57BL6 male mice that subsequently underwent evaluation of swallowing function by videofluoroscopic swallow study (VFSS) and histological assessments for aspiration pneumonia induced by lipopolysaccharide (LPS). VFSS examinations demonstrated that unilateral vagotomy did not cause apparent aspiration in mice, but it resulted in a significant loss of body weight (BW) due to decreased oral intake. In addition, when aspiration pneumonia was induced by forced administration of LPS, significantly prolonged BW loss and severe infiltration of inflammatory cells associated with aspiration pneumonia were observed in the mice that underwent unilateral vagotomy. In conclusion, the vagotomized mice showed appropriate characteristics as a model of aspiration pneumonia caused by multiple factors, including the paralysis of vocal fold movement and respiratory distress. This model can help elucidate the pathogenesis of aspiration pneumonia and the treatment methods for the respiration-compromised model.
Management of cholesterol granuloma due to eosinophilic otitis media using large ventilation tube. International-journal Peer-reviewed

Kento Ishigaki, Ryoukichi Ikeda, Yuta Kobayashi, Masayuki Shirakura, Shotaro Koizumi, Takuya Yoshida, Jun Suzuki, Kiyoto Shiga, Tetsuaki Kawase, Yukio Katori

Auris, nasus, larynx　2023/02/13

DOI： 10.1016/j.anl.2023.01.014 　

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A 46-year-old man who had been diagnosed with eosinophilic otitis media (EOM) and eosinophilic chronic rhinosinusitis was referred to our department. He suffered from bilateral earache, clogged ear sensation, and otorrhea associated with EOM. He had been treated with a myringotomy and a ventilation tube (VT) insertion. However, his symptoms did not improve, and the VT repeatedly fell out. We performed canal wall down mastoidectomy via a retro-auricular incision to remove the presumed cholesterol granuloma (CG) and a long-term VT insertion. The VT fell out repeatedly. Therefore, a large VT that Komune devised was inserted. Four months after reinsertion, there was no evidence of recurrent otorrhea or fallout of a large VT. A large VT insertion could be useful in the severe case of EOM with CG.
Postoperative serum interleukin-6 level as a risk factor for development of hyperactive delirium with agitation after head and neck surgery with free tissue transfer reconstruction. International-journal Peer-reviewed

Takayuki Imai, Sinkichi Morita, Kohsei Hasegawa, Takahiro Goto, Yukio Katori, Yukinori Asada

Auris, nasus, larynx　2023/02/06

DOI： 10.1016/j.anl.2023.01.005 　

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OBJECTIVE: Occurrence of hyperactive postoperative delirium (POD) with agitation after head and neck surgery with free tissue transfer reconstruction (HNS-FTTR) is associated with the risk of life-threatening complications. The relationships between occurrence of hyperactive POD after HNS-FTTR and inflammatory markers reflecting the surgical stress response, represented by postoperative interleukin-6 levels, are not fully understood. METHODS: A retrospective study was conducted on 221 consecutive patients who underwent HNS-FTTR at our department between September 2016 and December 2021. Potential risk factors for POD were examined, including age, operation time, intraoperative blood loss, and postoperative serum levels of blood parameters such as interleukin-6, C-reactive protein, and neutrophil-to-lymphocyte ratio. RESULTS: Hyperactive POD with agitation was observed in 54 subjects (24.4%). The postoperative hospital stay in the POD group was significantly longer than that in the non-POD group (median: 32.5 days vs. 28 days; p=0.0129). Multivariate logistic regression analysis identified age (in years) (odds ratio: 1.102; p<0.0001), operation time (min) (odds ratio: 1.004; p=0.0359), and postoperative serum interleukin-6 level (pg/mL) (odds ratio: 1.005; p=0.0384) as significant risk factors for development of POD. In a receiver operating characteristic curve and area under the curve analysis, the cut-off value for postoperative serum interleukin-6 level to predict POD development was 82.5 pg/mL. The postoperative serum interleukin-6 ≥82.5 pg/mL group developed hyperactive POD with agitation significantly more often than the postoperative serum IL-6 <82.5 pg/mL group (odds ratio: 4.400; p<0.0001). The postoperative serum IL-6 ≥82.5 pg/mL group also had significantly longer postoperative hospital stay (41.58 ± 33.42 days vs. 31.73 ± 22.89 days; p=0.0151), older age (68.60 ± 9.99 years vs. 64.30 ± 12.58 years; p=0.0054), and longer operation time (625.4 ± 114.05 min vs. 575.5 ± 98.73 min; p=0.0009) than the postoperative serum IL-6 <82.5 pg/mL group. CONCLUSION: Postoperative serum interleukin-6 level, as well as age and operation time, were identified as significant independent risk factors for development of hyperactive POD with agitation after HNS-FTTR. Inflammation is a potential target for the prevention and treatment of POD after HNS-FTTR.
Impact of Persistent Multidrug-Resistant Gram-Negative Bacteremia on Clinical Outcome and Mortality International-journal Peer-reviewed

Shiori Kitaya, Hajime Kanamori, Yukio Katori, Koichi Tokuda

Antibiotics　12　(2)　313-313　2023/02/03
Publisher: MDPI AG
DOI： 10.3390/antibiotics12020313 　

eISSN： 2079-6382

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The clinical aspects of persistent bacteremia (PB) caused by gram-negative rods (GNRs) in terms of antimicrobial resistance (AMR) and PB clearance status are unclear. This secondary analysis of a retrospective cohort study investigated differences in PB caused by Enterobacterales and glucose non-fermentative GNRs (NF-GNRs) based on AMR and PB clearance. We retrospectively surveyed medical records at Tohoku University Hospital. Patients for whom blood cultures were performed between January 2012 and December 2021 were recruited. PB cases were grouped based on AMR and PB clearance; the characteristics of PB due to each bacterial pathogen were examined. The main outcome variable was mortality. The late (30–90-day) mortality rate was significantly higher in the multidrug-resistant (MDR) group than in the non-MDR group for Enterobacterales. However, no significant difference was noted in mortality rates between NF-GNRs with and without AMR. Mortality rates tended to be higher in the non-PB-clearance group than in the clearance group for both Enterobacterales and NF-GNRs. Since the mortality rate was higher in the MDR group in the case of Enterobacterales PB, more careful management is necessary for this condition. Follow-up blood cultures and confirming the clearance of PB are useful for improving the survival rate.
Clinical and Epidemiological Characteristics of Persistent Bacteremia: A Decadal Observational Study International-journal Peer-reviewed

Shiori Kitaya, Hajime Kanamori, Hiroaki Baba, Kengo Oshima, Kentarou Takei, Issei Seike, Makoto Katsumi, Yukio Katori, Koichi Tokuda

Pathogens　12　(2)　212-212　2023/01/29
Publisher: MDPI AG
DOI： 10.3390/pathogens12020212 　

eISSN： 2076-0817

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Background: Bloodstream infections (BSIs), including persistent bacteremia (PB), are a leading source of morbidity and mortality globally. PB has a higher mortality rate than non- PB, but the clinical aspects of PB in terms of the causative pathogens and the presence of clearance of PB are not well elucidated. Therefore, this study aimed to describe the clinical and epidemiological characteristics of PB in a real-world clinical setting. Methods: We performed a retrospective observational survey of patients who underwent blood culture between January 2012 and December 2021 at Tohoku University Hospital. Cases of PB were divided into three groups depending on the causative pathogen: gram-positive cocci (GPC), gram-negative rods (GNRs), and Candida spp. For each group, we examined the clinical and epidemiological characteristics of PB, including differences in clinical features depending on the clearance of PB. The main outcome variable was mortality, assessed as early (30-day), late (30–90 day), and 90-day mortality. Results: Overall, we identified 31,591 cases of single bacteremia; in 6709 (21.2%) cases, the first blood culture was positive, and in 3124 (46.6%) cases, a follow-up blood culture (FUBC) was performed. Of the cases with FUBCs, 414 (13.2%) were confirmed to be PB. The proportion of PB cases caused by Candida spp. was significantly higher (29.6%, 67/226 episodes) than that for GPC (11.1%, 220/1974 episodes, p < 0.001) and GNRs (12.1%, 100/824 episodes, p < 0.001). The Candida spp. group also had the highest late (30–90 day) and 90-day mortality rates. In all three pathogen groups, the subgroup without the clearance of PB tended to have a higher mortality rate than the subgroup with clearance. Conclusions: Patients with PB due to Candida spp. have a higher late (30–90 day) and 90-day mortality rate than patients with PB due to GPC or GNRs. In patients with PB, FUBCs and confirming the clearance of PB are useful to improve the survival rate.
Videofluoroscopic Dysphagia Scale as an Additional Indicator of Gastrostomy in Patients with Amyotrophic Lateral Sclerosis with Dysphagia. Peer-reviewed

Tomomi Shijo, Ryoukichi Ikeda, Naoki Suzuki, Jun Ohta, Jun Suzuki, Ai Hirano-Kawamoto, Kengo Kato, Kensuke Ikeda, Rumiko Izumi, Shio Mitsuzawa, Hitoshi Warita, Masaaki Kato, Masashi Aoki, Yukio Katori

The Tohoku journal of experimental medicine　259　(4)　293-300　2023/01/26

DOI： 10.1620/tjem.2023.J005 　

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Pseudobulbar palsy and bulbar palsy cause dysphagia in patients with amyotrophic lateral sclerosis (ALS). Dysphagia in patients with ALS not only increases the risk of aspiration and pneumonia but also leads to malnutrition and weight loss, which are poor prognostic factors. Gastrostomy is the preferred route of feeding and nutritional support in patients with dysphagia. However, there are no established standards to determine the ideal timing of gastrostomy for patients with ALS. Therefore, we used the videofluoroscopic dysphagia scale (VDS), which objectively quantifies swallowing function, in videofluoroscopic swallowing study (VFSS) to investigate whether this scale at diagnosis can be a useful predictor for the timing of gastrostomy. We retrospectively evaluated 22 patients with ALS who were diagnosed at our hospital. We assessed the VDS scores in all patients within 3 months of diagnosis. A decline in the ALS functional rating scale revised (ALSFRS-R) scores was used as an indicator of disease progression. As a result, we found that the VDS score of the pharyngeal phase and the total VDS score were significantly correlated with the ΔALSFRS-R scores. These scores were also associated with the existing indicators for the timing of gastrostomy, i.e., decreased body weight and percent-predicted forced vital capacity. We demonstrated the noninferiority of the VDS scores relative to the existing indicators. In addition, the VDS score of the pharyngeal phase was significantly correlated with the time from diagnosis to gastrostomy. The VDS score could estimate the timing of gastrostomy in patients with ALS with dysphagia at diagnosis.
Long-term tumor growth and hearing after conservative management of vestibular schwannomas. International-journal Peer-reviewed

Kazutake Yagi, Ryoukichi Ikeda, Jun Suzuki, Hiroki Sunose, Tetsuaki Kawase, Yukio Katori

Acta oto-laryngologica　1-6　2023/01/24

DOI： 10.1080/00016489.2023.2168747 　

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BACKGROUND: There has been no report of a detailed long-term study of hearing at defined frequencies. AIMS/OBJECTIVES: This study aimed to evaluate long-term vestibular shwannoma (VS) growth and long-term changes in hearing thresholds at defined frequencies. METHODS: We retrospectively retrieved the medical records of 67 VS patients. Cases that were followed up for more than 5 years were analyzed. RESULTS: Tumor growth was observed in 15 cases (22.4%) and 6 cases underwent gamma knife treatment (9.0%). The longest case of tumor growth and gamma knife treatment was observed 11 years after the initial diagnosis. Hearing thresholds at 500-2000 Hz was significantly different between the no growth and growth group (p < .05). Particularly at 1000 Hz, there was a significant difference between the two groups from an early time-point. CONCLUSIONS AND SIGNIFICANCE: Even a 10-year or longer follow-up of VS may show an increase in tumor growth. Moreover, hearing thresholds, particularly at 1000 kHz, may predict tumor growth when following-up VS patients.
Long Non-Coding RNAs Associated with Mitogen-Activated Protein Kinase in Human Pancreatic Cancer Peer-reviewed

Tomohiko Ishikawa, Shinichi Fukushige, Yuriko Saiki, Katsuya Hirose, Takako Hiyoshi, Takenori Ogawa, Yukio Katori, Toru Furukawa

Cancers　15　(1)　303-303　2023/01/02
Publisher: MDPI AG
DOI： 10.3390/cancers15010303 　

eISSN： 2072-6694

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Long non-coding RNAs (lncRNAs) have emerged as a significant player in various cancers, including pancreatic cancer. However, how lncRNAs are aberrantly expressed in cancers is largely unknown. We hypothesized that lncRNAs would be regulated by signaling pathways and contribute to malignant phenotypes of cancer. In this study, to understand the significance of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK), which is a major aberrant signaling pathway in pancreatic cancer, for the expression of lncRNAs, we performed comparative transcriptome analyses between pancreatic cancer cell lines with or without activation of MAPK. We identified 45 lncRNAs presumably associated with MAPK in pancreatic cancer cells; among these, LINC00941 was consistently upregulated by MAPK. The immediate genomic upstream region flanking LINC00941 was identified as a promoter region, the activity of which was found to be preferentially associated with MAPK activity via ETS-1 binding site. LINC00941 promoted cell proliferation in vitro. Moreover, TCGA data analysis indicated that high expression of LINC00941 was associated with poor prognosis of patients with pancreatic cancer. Transcriptomes comparing transcriptions between cells with and without LINC00941 knockdown revealed 3229 differentially expressed genes involved in 44 biological processes, including the glycoprotein biosynthetic process, beta-catenin-TCF complex assembly, and histone modification. These results indicate that MAPK mediates the aberrant expression of lncRNAs. LINC00941 is the lncRNA by MAPK most consistently promoted, and is implicated in the dismal prognosis of pancreatic cancer. MAPK-associated lncRNAs may play pivotal roles in malignant phenotypes of pancreatic cancer, and as such might represent both potentially valid therapeutic targets and diagnostic biomarkers.
Postoperative Swallowing Function in Patients with Deep Neck Infection. International-journal Peer-reviewed

Shohei Ashizawa, Takuma Hisaoka, Ryoukichi Ikeda, Rina Kamihata, Jun Suzuki, Ai Hirano-Kawamoto, Jun Ohta, Yukio Katori

Biomedicine hub　8　(1)　72-78　2023
Publisher: S. Karger AG
DOI： 10.1159/000533526 　

eISSN： 2296-6870

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INTRODUCTION: Early detection of dysphagia risk, initiating rehabilitation, and resumption of appropriate diet based on swallowing function is important during deep neck infection (DNI) control. This study aimed to evaluate the extent of cervical abscess development, particularly in the deep neck space, and its relationship to postoperative swallowing function. METHODS: A retrospective chart review was performed for all DNI cases treated between April 2015 and April 2021. Deep neck spaces were divided into categories based on computed tomography findings. Functional Oral Intake Scale (FOIS) scores of 4 or higher was defined as normal or slight swallowing disorder and 3 or lower as dysphagia. RESULTS: Seventeen cases were included in the analysis. Based on FOIS, 14 cases were classified into the dysphagia group at 2 weeks after surgery, 11 cases at 4 weeks, and 8 cases at 8 weeks. There was no significant difference between the location of the abscess and dysphagia at 2 weeks after surgery. Patients with anterior cervical space abscess significantly increased dysphagia 4 weeks (p = 0.018) and 8 weeks (p = 0.036) after surgery. CONCLUSION: Abscess formation in the anterior cervical space may be associated with prolonged dysphagia after treatment due to inflammation and scarring of the muscles associated with swallowing.
Anatomy and pathology of lymphatic vessels under physiological and inflammatory conditions in the mouse diaphragm International-journal Peer-reviewed

Peerada Ngamsnae, Tatsuma Okazaki, Yuzhou Ren, Yunxiang Xia, Hikaru Hashimoto, Ryoukichi Ikeda, Yohei Honkura, Yukio Katori, Shin-Ichi Izumi

Microvascular Research　145　104438-104438　2023/01
Publisher: Elsevier BV
DOI： 10.1016/j.mvr.2022.104438 　

ISSN： 0026-2862

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The lymphatic vessels in the parietal pleura drain fluids. Impaired drainage function and excessive fluid entry in the pleural cavity accumulate effusion. The rat diaphragmatic lymphatics drain fluids from the pleura to the muscle layer. Lymphatic subtypes are characterized by the major distribution of discontinuous button-like endothelial junctions (buttons) in initial lymphatics and continuous zipper-like junctions (zippers) in the collecting lymphatics. Inflammation replaced buttons with zippers in tracheal lymphatics. In the mouse diaphragm, the structural relationship between the lymphatics and blood vessels, the presence of lymphatics in the muscle layer, and the distributions of initial and collecting lymphatics are unclear. Moreover, the endothelial junctional alterations and effects of vascular endothelial growth factor receptor (VEGFR) inhibition under pleural inflammation are unclear. We subjected the whole-mount mouse diaphragms to immunohistochemistry. The lymphatics and blood vessels were distributed in different layers of the pleural membrane. Major lymphatic subtypes were initial lymphatics in the pleura and collecting lymphatics in the muscle layer. Chronic pleural inflammation disorganized the stratified layers of the lymphatics and blood vessels and replaced buttons with zippers in the pleural lymphatics, which impaired drainage function. VEGFR inhibition under inflammation maintained the vascular structures and drainage function. In addition, VEGFR inhibition maintained the lymphatic endothelial junctions and reduced the blood vessel permeability under inflammation. These findings may provide new targets for managing pleural effusions caused by inflammation, such as pleuritis and empyema, which are common pneumonia comorbidities.
Preoperative serum interleukin-6 level in head and neck cancer reflects systemic inflammatory response and is a predictor of postoperative prognosis. International-journal Peer-reviewed

Takayuki Imai, Kazuki Nakamura, Sinkichi Morita, Kohsei Hasegawa, Takahiro Goto, Yukio Katori, Yukinori Asada

Japanese journal of clinical oncology　2022/12/08

DOI： 10.1093/jjco/hyac185 　

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BACKGROUND: The outcome of head and neck cancer has improved in recent years but survival is not yet satisfactory. Interleukin (IL)-6 is a representative inflammatory cytokine and inducer of systemic inflammatory response. It is not known whether preoperative serum level of IL-6 is a prognostic factor in head and neck cancer surgery. METHODS: We studied 181 consecutive patients who underwent head and neck surgery with free tissue transfer reconstruction (HNS-FTTR) between September 2016 and December 2020. Whether preoperative serum IL-6 level was a prognostic risk factor was retrospectively investigated by univariate and multivariate analyses. We also investigated the association between preoperative IL-6 level and representative systemic inflammatory response markers. RESULTS: The preoperative IL-6 ≥ 8 pg/mL group had a significantly worse prognosis than the preoperative IL-6 < 8 pg/mL group (overall survival [OS]: hazard ratio [HR] 3.098, P = 0.0006; disease-specific survival [DSS]: HR 3.335, P = 0.0008). In multivariate analysis, IL-6 ≥ 8 pg/mL and age ≥ 70 years were independent poor prognostic factors for OS (HR 1.860, P = 0.0435 and HR 1.883, P = 0.0233, respectively). The only independent poor prognostic factor for DSS was IL-6 ≥ 8 pg/mL (HR 2.052, P = 0.0329). Serum albumin was significantly lower and serum C-reactive protein and neutrophil-to-lymphocyte ratio were significantly higher in the IL-6 ≥ 8 pg/mL group than in the IL-6 < 8 pg/mL group (all P < 0.0001). CONCLUSIONS: Preoperative serum IL-6 level is an independent poor prognostic factor for both OS and DSS after HNS-FTTR, reflecting the degree of preoperative systemic inflammatory response.
Eustachian Tube Functions in Concurrent Chemoradiotherapy for Head and Neck Cancer Patients. International-journal

Akira Ohkoshi, Ryoukichi Ikeda, Jun Suzuki, Takaya Yamamoto, Ryo Ishii, Kenjiro Higashi, Shun Wakamori, Yuki Nakayama, Ayako Nakanome, Takenori Ogawa, Yukio Katori

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India　74　(Suppl 3)　6307-6312　2022/12

DOI： 10.1007/s12070-021-03058-x 　

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Ototoxicity is a dose-limiting adverse event for concurrent chemoradiotherapy (CCRT) with high-dose cisplatin for locally advanced head and neck squamous cell carcinoma (HNSCC). Both irradiation to the Eustachian tube (ET) and weight loss are risk factors for patulous ET. The aim of this prospective, observational study was to elucidate the incidences of patulous ET conditions before and after CCRT in HNSCC patients by means of ET function tests. This prospective, observational study was conducted in 27 HNSCC patients who received CCRT with high-dose cisplatin, and ET function tests (sonotubometry and tubo-tympano-aerodynamic graphy) were performed before and 3 months after CCRT. Factors potentially affecting the incidence of patulous ET conditions after CCRT were evaluated. Of the 54 ears from 27 patients investigated, patulous ET conditions were observed in 12 ears (22.2%) from 9 patients (33.3%) before CCRT and 15 ears (27.8%) from 11 patients (40.7%) at 3 months after CCRT. Only patulous ET conditions before CCRT in each ear were significantly associated with patulous ET conditions after CCRT (p = 0.010). This is the first report to describe the incidences of patulous ET conditions before and after CCRT in HNSCC patients. HNSCC patients are potentially at higher risk of patulous ET.
Establishment of Neh2-Cre:tdTomato reporter mouse for monitoring the exposure history to electrophilic stress. International-journal Peer-reviewed

Hiroshi Kitamura, Tetsuya Oishi, Shohei Murakami, Tomoe Yamada-Kato, Isao Okunishi, Masayuki Yamamoto, Yukio Katori, Hozumi Motohashi

Free radical biology & medicine　193　(Pt 2)　610-619　2022/11/08

DOI： 10.1016/j.freeradbiomed.2022.11.004 　

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Cells are often exposed to exogenous and endogenous redox disturbances and exert their protective mechanisms in response to stimuli. The KEAP1-NRF2 system plays pivotal roles in counteracting oxidative damage. Due to the transient nature of NRF2 activation, the identification of cells in which NRF2 is activated in response to systemic stimuli is sometimes not easy. To examine the electrophilic stress response at a single-cell resolution, we aimed to develop a new reporter mouse in this study. A cell-tracing strategy exploiting Cre recombinase-mediated activation of a reporter gene was chosen for stable detection of reporter expression instead of real-time monitoring of the cellular response. We established a transgenic mouse line expressing the Neh2-Cre recombinase fusion protein. As Neh2 is an amino-terminal domain of NRF2 that serves as a degron and mediates KEAP1-dependent degradation and electrophile-inducible stabilization, Neh2-Cre was expected to be activated in response to electrophiles. The Neh2-Cre transgenic mouse was crossed with the ROSA26-loxP-stop-loxP-tdTomato reporter mouse (ROSA-LSL-tdTomato mouse). The compound mutant reporter mice exhibited accumulation of tdTomato-positive cells in various organs after repeated administration of CDDO-Im, one of the NRF2-inducing electrophiles. The mice were also successfully used for the detection of cells that experienced a cisplatin-induced electrophilic stress response.
Simple Endoscopic Method of Scoring Swallowing Function After Treatment in Advanced Head and Neck Cancer Patients. International-journal Peer-reviewed

Akira Ohkoshi, Takenori Ogawa, Kengo Kato, Ayako Nakanome, Ryo Ishii, Takuya Yoshida, Yuki Nakayama, Yukio Katori

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India　74　(3)　265-271　2022/09

DOI： 10.1007/s12070-020-02307-9 　

ISSN： 2231-3796

eISSN： 0973-7707
COVID-19-Related Symptoms during the SARS-CoV-2 Omicron (B.1.1.529) Variant Surge in Japan. Peer-reviewed

Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Noriko Sugawara, Hiroshi Egusa, Kaoru Igarashi, Motoo Fujita, Shigeo Kure, Shin Takayama, Michiaki Abe, Akiko Kikuchi, Minoru Ohsawa, Kota Ishizawa, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tadashi Ishii

The Tohoku journal of experimental medicine　258　(2)　103-110　2022/08/25

DOI： 10.1620/tjem.2022.J067 　

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The exact profiles of the clinical symptoms related to the SARS-CoV-2 Omicron variant (B.1.1.529) remain largely uncertain. Therefore, this study aimed to clarify the clinical manifestations of infection with this variant. We enrolled individuals who were tested by quantitative nasopharyngeal swab reverse transcription-polymerase chain reaction (RT-PCR) test at a large screening center in a city of Japan during the B.1.1.529 Omicron variant wave between January and May 2022, after contact with COVID-19 patients. Swab tests were planned to be performed approximately 4-5 days after contact. The presence of COVID-19-related symptoms was assessed at the swab test site. Among the 2,507 enrolled individuals, 943 (37.6%) were RT-PCR test-positive and 1,564 (62.4%) were test-negative. Among the 943 PCR test-positive participants, the prevalence of the symptoms was as follows: 47.3% with cough, 32.9% with sore throat, 18.4% with fatigability, 12.7% with fever of ≥ 37.5℃, 9.9% with dyspnea, 2.1% with dysosmia, and 1.4% with dysgeusia. The prevalence of cough, sore throat, dyspnea, and fatigability was higher among adults aged ≥ 18 years than among children and adolescents. The prevalence of dysosmia and dysgeusia remarkably decreased during the Omicron wave (1-3%) compared to during the pre-Omicron variant waves (15-25%). In summary, common COVID-19-related symptoms during the Omicron variant wave included cough and sore throat, followed by fatigability, fever, and dyspnea. The prevalence of most of these symptoms was higher in adults than in non-adults. The prevalence of dysosmia and dysgeusia remarkably decreased with the Omicron variant than with pre-Omicron variants.
Clinical and Epidemiological Characteristics of Bloodstream Infections in Head and Neck Cancer Patients: A Decadal Observational Study. International-journal Peer-reviewed

Shiori Kitaya, Risako Kakuta, Hajime Kanamori, Akira Ohkoshi, Ryo Ishii, Kazuhiro Nomura, Koichi Tokuda, Yukio Katori

Journal of clinical medicine　11　(16)　2022/08/17

DOI： 10.3390/jcm11164820 　

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This retrospective study aims to describe the clinico-epidemiological characteristics of bloodstream infections (BSIs) and the risk factors in patients with head and neck cancer (n = 227) treated at the Department of Otolaryngology, Head and Neck Surgery, Tohoku University Hospital between April 2011 and March 2021. Overall, 23.3% of blood cultures were positive. In the culture-positive group, catheter-related bloodstream infections (CRBSIs) were the most common (38.8%), followed by respiratory tract infections (19.4%), and catheter-associated urinary tract infections (6.0%). Methicillin-resistant Staphylococcus aureus (26.9%), Staphylococcus epidermidis (17.9%), and Pseudomonas aeruginosa (10.4%) infections were common. The most frequent treatment for head and neck cancer was surgery (23.9%), followed by treatment interval or palliative care (19.4%), and single radiotherapy (13.4%). The 30-day mortality rate was significantly higher in the BSI than in the non-BSI group (10.4% vs. 1.8%, respectively). CRBSIs are the most frequent source of BSIs in patients with head and neck cancer. In conclusion, central venous catheters or port insertion should be used for a short period to prevent CRBSIs. The risk of developing BSI should be considered in patients with pneumonia. Understanding the epidemiology of BSIs is crucial for diagnosing, preventing, and controlling infections in patients with head and neck cancer.
Bedside evaluation of swallowing function to predict aspiration pneumonia in Duchenne muscular dystrophy. International-journal Peer-reviewed

Ai Kawamoto-Hirano, Ryoukichi Ikeda, Toshiaki Takahashi, Sayaka Taniguchi, Masaru Yoshioka, Hiroyasu Tanaka, Hideki Oizumi, Tomoko Totsune, Saki Oshiro, Toru Baba, Atsushi Takeda, Yuta Kobayashi, Jun Ohta, Yukio Katori

Auris, nasus, larynx　50　(2)　247-253　2022/08/13

DOI： 10.1016/j.anl.2022.07.006 　

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OBJECTIVE: Aspiration pneumonia is one of the leading causes of death in patients with muscular dystrophy; therefore, it is important to predict its occurrence in the clincal setting. We aimed to examine the usefulness of repeated saliva swallowing test (RSST), modified water swallowing test (MWST), and flexible endoscopic evaluation of swallowing (FEES) for evaluating the Hyodo score at the bedside, to predict the risk of aspiration pneumonia in patients with Duchenne muscular dystrophy (DMD). METHODS: In this retrospective cohort study involving 43 patients, we evaluated the swallowing function using the RSST, MWST, and FEES, and predicted the likelihood of aspiration pneumonia within 2 years after the assessment. The Hyodo score, a scoring system for evaluating the swallowing function determined by the FEES, was used. RESULTS: Pneumonia was observed in 14 patients (32.6%). The RSST was not significantly useful for predicting the onset of pneumonia. The MWST was reported to have a cutoff value of < 4 points. Significantly more patients in the pneumonia group had an MWST score of < 4 points. The results revealed that the occurrence of pneumonia could be predicted based on a Hyodo cutoff score of ≥ 6. Significantly more patients in the pneumonia group had an MWST score of < 4 or a Hyodo score of ≥ 6. CONCLUSIONS: Combining MWST and FEES is useful for evaluating the bedside swallowing function and predicting the onset of pneumonia.
Effectiveness of third vaccine dose for coronavirus disease 2019 during the Omicron variant pandemic: a prospective observational study in Japan International-journal Peer-reviewed

Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Noriko Sugawara, Hiroshi Egusa, Kaoru Igarashi, Motoo Fujita, Shigeo Kure, Shin Takayama, Michiaki Abe, Akiko Kikuchi, Minoru Ohsawa, Kota Ishizawa, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tadashi Ishii

Scientific Reports　12　(1)　13589-13589　2022/08/10
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s41598-022-17990-7 　

eISSN： 2045-2322

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Abstract The administration of a third booster dose of messenger ribonucleic acid (mRNA) vaccines against coronavirus disease 2019 (COVID-19) has progressed worldwide. Since January 2022, Japan has faced a nationwide outbreak caused by the Omicron variant, which occurred simultaneously with the progression of mass vaccination with the third booster dose. Therefore, this study evaluated the effectiveness of the third dose of vaccine by reverse transcription-polymerase chain reaction (RT-PCR) test using nasopharyngeal swab samples from adults aged ≥ 18 years tested after having close contact with COVID-19 cases between January and May 2022. Participants who completed only one dose were excluded from the study. Among the 928 enrolled participants, 139 had never been vaccinated, 609 had completed two doses, 180 had completed three doses before the swab test, and the overall RT-PCR test positivity rate in each group was 48.9%, 46.0%, and 32.2%, respectively. The vaccine effectiveness of the third dose to prevent infection after close contact was approximately 40% (95% confidence interval: 20–60%), which was the highest at 10–70 days after receiving the third dose. In conclusion, the effectiveness of the three-dose mRNA COVID-19 vaccine after close contact during the Omicron outbreak is approximately 40%.
Immunohistochemical localization of d-β-aspartic acid in congenital and acquired middle ear cholesteatoma. International-journal Peer-reviewed

Shiori Kitaya, Ryoukichi Ikeda, Jun Suzuki, Hidetoshi Oshima, Yuri Nomura, Yusuke Kusano, Nobuo Ohta, Tetsuaki Kawase, Kazue Ise, Kazuhiro Murakami, Yasuhiro Nakamura, Hironobu Sasano, Yukio Katori

Laryngoscope investigative otolaryngology　7　(4)　1155-1163　2022/08

DOI： 10.1002/lio2.856 　

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Objective/Hypothesis: Middle ear cholesteatoma is characterized by abnormal growth of the keratinizing squamous epithelium of the temporal bone. d-β-aspartic acid is the major isomer of d-aspartic acid found in elderly tissue. We assessed the immunoreactivity to k-β-aspartic acid of congenital and acquired middle ear cholesteatomas. Study Design: Case-control studies. Material and Methods: Tissue samples were collected from 21 patients comprising 21 ears with congenital middle ear cholesteatoma and 26 patients comprising 29 ears with acquired type. Their clinical and histopathological features were investigated. We divided the middle ear cholesteatoma samples into three layers: the perimatrix, matrix, and cystic contents. The patterns of immunoreactivity to d-β-aspartic acid expression were then assessed immunohistochemically. Results: Two patterns of immunoreactivity to d-β-aspartic acid were detected in middle ear cholesteatoma: infiltrative and diffuse. In congenital middle ear cholesteatoma, d-β-aspartic acid expression was observed throughout all the layers (perimatrix, matrix, and cystic contents), and immunoreactivity to d-β-aspartic acid was dramatically strong in all layers. The expression levels of d-β-aspartic acid to the cystic content and perimatrix were significantly higher in congenital middle ear cholesteatoma than in the acquired type. Conclusions: This study showed the expression levels of d-β-aspartic acid in middle ear cholesteatoma to differ significantly between congenital and acquired middle ear cholesteatoma. Our results indicate that overexpression of d-β-aspartic acid is likely to be involved in the pathogenesis of cholesteatoma, and we speculate that d-β-aspartic acid could be a novel biomarker for, and a therapeutic target in, congenital and acquired middle ear cholesteatoma. Level of Evidence: 4.
Expression of Periostin in Vocal Fold Polyps. Peer-reviewed

Yutaka Tateda, Ryoukichi Ikeda, Risako Kakuta, Junya Ono, Kenji Izuhara, Takenori Ogawa, Kazue Ise, Hiroki Shimada, Keigo Murakami, Kazuhiro Murakami, Yasuhiro Nakamura, Yukio Katori, Nobuo Ohta

The Tohoku journal of experimental medicine　258　(1)　55-62　2022/07/07

DOI： 10.1620/tjem.2022.J055 　

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Long-term voice abuse or sudden vocal fold microvascular disruption may lead to injury and subsequent repair/remodeling in the vocal fold mucosa. Periostin is known to be involved in airway remodeling and also in various otolaryngological diseases. The aim of this article was to investigate the expression and the role of periostin in the formation of vocal fold polyps. The expression patterns of periostin in 59 surgical specimens of vocal fold polyps from 54 patients were investigated immunohistochemically. Normal vocal fold mucosa specimens from 5 patients who had undergone total laryngectomy were used as the control group. Retrospective study with planned data collection was conducted at Tohoku Medical and Pharmaceutical University. Expression of periostin was detected in 43 (72.9%) samples and four patterns of periostin expression were observed in vocal fold polyps: negative type, superficial type, infiltrative type, and diffuse type. An association was observed between periostin expression patterns and the histological subtypes of vocal fold polyps. The infiltrative pattern of periostin expression was significantly dominant in vascular-hyaline types. Expression of transforming growth factor-β (TGF-β) was also detected in the vocal fold polyps. Our results confirmed that periostin might be involved in certain pathological changes in vocal fold polyps, such as extracellular matrix accumulation, local fibrosis, and formation and development of vocal fold polyps.
Cardiovocal Syndrome Associated With Idiopathic Pulmonary Arterial Hypertension: A Case Report and Literature Review. International-journal Peer-reviewed

Kohhei Ohi, Jun Suzuki, Ryoukichi Ikeda, Risako Kakuta, Yukio Katori

Cureus　14　(7)　e27070　2022/07

DOI： 10.7759/cureus.27070 　

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Cardiovocal syndrome is left recurrent laryngeal nerve palsy associated with cardiovascular disease. Herein, we report a rare case of left recurrent laryngeal nerve palsy caused by idiopathic pulmonary arterial hypertension. A 40-year-old woman diagnosed with idiopathic pulmonary arterial hypertension was referred to our department for occult infection foci in the ear, nose, and throat (ENT). She had no apparent subjective symptoms in the ENT area, including hoarseness. Flexible laryngoscopy revealed left vocal cord paralysis, and contrast-enhanced computed tomography revealed dilatation of the pulmonary trunk, bilateral pulmonary arteries, and right ventricle, suggesting compression of the left recurrent laryngeal nerve. In our daily practice, when we encounter a left recurrent laryngeal nerve palsy that seems to be endogenous, cardiovascular lesions should be ruled out.
Endoscopic Resection of Nasal Mucosal Melanoma Using Temporary Transseptal Access. International-journal Peer-reviewed

Jun Suzuki, Kenjiro Higashi, Tomotaka Hemmi, Hiroyuki Ikushima, Yukio Katori

Cureus　14　(7)　e26904　2022/07

DOI： 10.7759/cureus.26904 　

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Nasal mucosal melanoma (NMM) is a rare tumor with a poor prognosis. Although an endoscopic resection of malignant nasal tumor now becomes a treatment of choice when the surgical margin can be secured, it is still controversial. We report three cases of NMM that was successfully removed en bloc with clear margins by endoscopic surgery with temporal transseptal access. Cases of a 78-year-old woman, an 83-year-old man, and an 81-year-old man with NMM arising from the inferior turbinate who underwent endoscopic resection of the tumor are discussed in detail. We made temporal transseptal access using septal mucosal flaps. We moved the nasal cavity-occupying tumor to the contralateral side to create a working space to perform endoscopic en bloc resections. This technique is simple yet effective and less invasive than open craniofacial resections for removing malignancies arising from the inferior turbinate.
Presence of Phlebitis in Aseptic Nasal Septal Abscess Complicated with Ulcerative Colitis; Possible Association with Granulomatosis with Polyangiitis: A Case Report. Peer-reviewed

Tomohiko Ishikawa, Jun Suzuki, Tsuyoshi Shirai, Shotaro Koizumi, Yoshinori Tsuchiya, Kasumi Hishinuma, Yasuhiro Nakamura, Yukio Katori

The Tohoku journal of experimental medicine　258　(1)　29-34　2022/06/30

DOI： 10.1620/tjem.2022.J053 　

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Although nasal septal abscesses are uncommon, their cosmetic complications can be severe. Hence, prompt diagnosis and treatment are important. Here, we report a case of aseptic nasal septal abscess in a patient with proteinase 3-antineutrophil cytoplasmic antibody (PR3-ANCA)-positive ulcerative colitis (UC), in which phlebitis was observed and granulomatosis with polyangiitis (GPA) might co-exist. A 27-year-old female suffered from intermittent abdominal pain and diarrhea for several years. She visited our hospital complaining of worsening swelling and pain in the middle forehead and fever lasting 2 weeks. Physical examination and computed tomography revealed severe swelling of the nasal septum. The patient was diagnosed with nasal septal abscess, and incision drainage and biopsy from the bilateral nasal septum were performed, which showed severe ulcerative neutrophilic mucositis with phlebitis. Simultaneously, blood examination yielded slight positivity for PR3-ANCA. Colonoscopy, including biopsy, revealed severe inflammation without vasculitis nor granuloma, which led to the diagnosis with PR3-ANCA-positive UC. Phlebitis in the nasal mucosa and elevated PR3-ANCA suggested co-existing GPA; hence, she was treated with glucocorticoids and rituximab. Following treatment, the nasal septal abscess and digestive symptoms disappeared. She was discharged on day 25 without symptom recurrence or major nasal deformity. For the prevention of nasal deformity due to persistent inflammation, prompt administration of immunosuppressive therapy should be considered with adequate evaluations for systemic diseases, including UC and GPA.
Nrf2 protects against radiation-induced oral mucositis via antioxidation and keratin layer thickening. International-journal Invited Peer-reviewed

Shun Wakamori, Keiko Taguchi, Yuki Nakayama, Akira Ohkoshi, Michael B Sporn, Takenori Ogawa, Yukio Katori, Masayuki Yamamoto

Free radical biology & medicine　188　206-220　2022/06/23

DOI： 10.1016/j.freeradbiomed.2022.06.239 　

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Radiation-induced oral mucositis is one of the most common adverse events in radiation therapy for head and neck cancers, but treatments for oral mucositis are limited to palliative and supportive care. New approaches are required to prevent radiation-induced mucositis and to improve treatments. The Keap1-Nrf2 system regulates cytoprotection against oxidative and electrophilic stresses. Nrf2 also regulates keratin layer thickness in mouse tongues. Therefore, we hypothesized that Nrf2 may protect the tongue epithelium against radiation-induced mucositis via elimination of reactive oxygen species and induction of keratin layer thickening. To test this hypothesis, we prepared a system for γ-ray exposure of restricted areas and irradiated the tongues of model mice with Nrf2 and Keap1 loss-of-function. We discovered that loss of Nrf2 expression indeed sensitized the tongue epithelium to radiation-induced ulcer formation with inflammation. Constitutive Nrf2 activation by genetic Keap1 knockdown alleviated radiation-induced DNA damage by increasing antioxidation. In agreement with the genetic Nrf2 activation model, the Nrf2 inducer CDDO-Im prevented irradiation damage to the tongue epithelium. These results demonstrate that Nrf2 activation has the potential to prevent the development of radiation-induced mucositis and that Nrf2 inducers are an important therapeutic drug for protection of the upper aerodigestive tract from radiation-induced mucositis.
Trismus after partial maxillectomy and radiotherapy: Free flap reconstruction versus prosthetic obturation. International-journal Peer-reviewed

Akira Ohkoshi, Ryo Ishii, Kenjiro Higashi, Ayako Nakanome, Kenichiro Ishikawa, Yukio Katori

Auris, nasus, larynx　2022/06/07

DOI： 10.1016/j.anl.2022.05.016 　

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OBJECTIVE: Partial maxillectomy and postoperative radiotherapy are both risk factors associated with trismus. This retrospective study aimed to evaluate the incidence and severity of trismus in patients following partial maxillectomy with or without postoperative radiotherapy and to compare free flap reconstruction and prosthetic obturation. METHODS: A retrospective review of 40 oral cancer patients who underwent partial maxillectomy with or without postoperative radiotherapy was performed. Maximum interincisal distance recorded at least 6 months after surgery was classified according to a revised subjective-objective management-analytical (SOMA) scale and compared between the free flap reconstruction group (n = 12) and the prosthetic obturation group (n = 28). RESULTS: Trismus was observed in 16/40 (40%) patients, and severe trismus was observed in 4/40 (10%) patients. Although no significant difference in trismus grade was observed between the free flap reconstruction and prosthetic obturation groups, both severe trismus and radiation-induced osteonecrosis were only seen in the prosthetic obturation group with postoperative radiotherapy. CONCLUSION: Free flap reconstruction was preferable to prosthetic obturation to avoid severe trismus and radiation-induced osteonecrosis in patients who underwent both partial maxillectomy and postoperative radiotherapy.
Fibroepithelial Polyps Originating from the Posterior Nasal Septum: A Case Report Peer-reviewed

Yuki Numano, Kazuhiro Nomura, Mika Watanabe, Mitsuru Sugawara, Tomotaka Hemmi, Jun Suzuki, Yukio Katori

The Tohoku Journal of Experimental Medicine　257　(4)　333-336　2022/06
Publisher: Tohoku University Medical Press
DOI： 10.1620/tjem.2022.j047 　

ISSN： 0040-8727

eISSN： 1349-3329

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Fibroepithelial polyps are benign tumors of mesodermal origin. They rarely occur in the nasal cavity, with only four such cases reported in the relevant English literature. The location was the inferior turbinate in three cases and anterior nasal septum in one case. The etiology has been suggested in other organs; however, it is entirely unknown in the nasal cavity. Pathological findings play an essential role in the diagnosis of fibroepithelial polyps. We report the case of a 76-year-old woman with fibroepithelial polyps originating from the posterior part of the nasal septum. The fibroepithelial polyps were white-yellow lobular masses that differed from a common inflammatory polyp. We made the diagnosis by excluding the other possible tumors based on a pathological examination. This is the first report about fibroepithelial polyps arising from the posterior nasal septum. She had no potential risk factors that might trigger fibroepithelial polyps in the nasal cavity. This case is a valuable example when considering the potential causes (e.g., female hormones and mechanical pressure) of nasal fibroepithelial polyps.
Impact on swallowing functions of arytenoid adduction in patients with unilateral vocal fold paralysis Peer-reviewed

Kenichi Watanabe, Kazutaka Kashima, Takeshi Sato, Tomomi Machida, Shin Fukudo, Yukio Katori

Auris Nasus Larynx　2022/06
Publisher: Elsevier BV
DOI： 10.1016/j.anl.2022.05.015 　

ISSN： 0385-8146
Sinonasal Inverted Papilloma Showing a Misleading Finding on Magnetic Resonance Imaging. International-journal

Yuki Numano, Kazuhiro Nomura, Mitsuru Sugawara, Tomotaka Hemmi, Jun Suzuki, Risako Kakuta, Yukio Katori

Ear, nose, & throat journal　1455613221095614-1455613221095614　2022/04/29

DOI： 10.1177/01455613221095614 　

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Sinonasal inverted papilloma (IP) is the most common benign tumor in sinonasal cavities. Treatment involves excising the whole tumor, so it is essential to evaluate the extent of the tumor by preoperative radiographic findings. Magnetic resonance imaging (MRI) is superior to computed tomography (CT) for determining a tumor's location as MRI can discern the difference between mucus and IP. We herein report a 51-year-old man with sinonasal IP treated with endoscopic sinus surgery (ESS). Preoperative MRI showed findings resembling a convoluted cerebriform pattern on T2-weighted imaging, but this site was not enhanced by intravenous gadolinium at all. We preoperatively suspected that this site was not part of the tumor but rather the accumulation of mucus, and indeed, we found no tumor at this site when we performed the surgery. This patient is a valuable example of misleading findings of IP on T2-weighted imaging and underscores the importance of contrast-enhanced T1-weighted imaging to determine the extent of IP.
Investigation of the diversity of human papillomavirus 16 variants and L1 antigenic regions relevant for the prevention of human papillomavirus-related oropharyngeal cancer in Japan. International-journal Peer-reviewed

Takuya Yoshida, Takenori Ogawa, Ayako Nakanome, Akira Ohkoshi, Ryo Ishii, Kenjiro Higashi, Tomohiko Ishikawa, Yukio Katori, Toru Furukawa

Auris, nasus, larynx　49　(6)　1033-1041　2022/04/28

DOI： 10.1016/j.anl.2022.04.006 　

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OBJECTIVE: This study aimed to investigate the distribution of human papillomavirus 16 (HPV16) variants that contribute to the development of HPV-related oropharyngeal carcinoma (HPV-OPC) in the Japanese population and to evaluate genetic variations in the sequence encoding the L1 antigen region of the viral outer shell that is targeted by existing vaccines and is relevant for designing a prevention strategy to combat the exponential increase in HPV-OPC cases in Japan. METHODS: Seventy Japanese HPV-OPC patients treated at Tohoku University Hospital were included in the study. DNA was extracted from formalin-fixed, paraffin-embedded tissue samples. Polymerase chain reaction and direct nucleotide sequencing were performed to determine the nucleotide polymorphisms necessary for the classification of HPV16 variants and to assess genetic diversity in the HPV16 L1 antigen region, including the BC, DE, EF, FG, and HI loops. RESULTS: The most common variant of HPV16 was the A4 sublineage (88.6%), conventionally called the Asian type, followed by the A1/2/3 (10.0%) sublineage, classified as the European type. The only nonsynonymous substitution detected in the L1 antigen loop region was p.N181T in the EF loop, which was found in 28/70 (40%) cases. In contrast, no nonsynonymous substitutions were observed in the DE, FG, and HI loops, which are particularly important regions in the antigen loop targeted by existing HPV vaccines. CONCLUSION: The most common HPV16 variant in Japanese HPV-OPC patients was the A4 subtype. The L1 antigen region is highly conserved, suggesting sufficient efficacy of existing HPV vaccines. These findings provide important information that will aid in the design of an HPV16 infection control strategy using existing HPV vaccines to prevent the spread of HPV-OPC in Japan.
Outcome of the 'waiting until spontaneous extrusion' strategy for long-term tympanostomy tube placement in children with cleft palate. International-journal

Yuri Nomura, Hidetoshi Oshima, Kazuhiro Nomura, Risako Kakuta, Ryoukichi Ikeda, Ai Kawamoto Hirano, Jun Ota, Tetsuaki Kawase, Yukio Katori

Acta oto-laryngologica　1-6　2022/04/22

DOI： 10.1080/00016489.2022.2041210 　

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BACKGROUND: Otitis media with effusion (OME) in children with cleft palate (CP) is known to be refractory to treatment and most of these patients undergo surgery for ventilation tube (VT) placement. OBJECTIVES: To identify the outcomes of children with CP using long-term VT with a 'waiting until spontaneous extrusion' strategy. MATERIAL AND METHODS: We retrospectively reviewed the medical records of all children with CP who visited our department from December 2016 to November 2017 and who received long-term VT placement in our department. Risk factors related to residual perforation and recurrence of OME were analyzed. RESULTS: A total of 106 children were included in this study. Our statistical analysis of 94 ears followed for more than three months after VT loss revealed that longer VT placement was associated with residual perforation, and shorter VT placement was associated with OME recurrence. Although a longer duration of VT placement was associated with an increased rate, extremely long-term VT placement was not associated with residual perforation, as expected. Half of the VTs were spontaneously extruded at 40 months after insertion. CONCLUSIONS AND SIGNIFICANCE: Long-term VT insertion using a waiting until spontaneous extrusion strategy is a potential option for children with CP.
A Pilot Study for Return of Individual Pharmacogenomic Results to Population-Based Cohort Study Participants.

Kinuko Ohneda, Masahiro Hiratsuka, Hiroshi Kawame, Fuji Nagami, Yoichi Suzuki, Kichiya Suzuki, Akira Uruno, Mika Sakurai-Yageta, Yohei Hamanaka, Makiko Taira, Soichi Ogishima, Shinichi Kuriyama, Atsushi Hozawa, Hiroaki Tomita, Naoko Minegishi, Junichi Sugawara, Inaho Danjoh, Tomohiro Nakamura, Tomoko Kobayashi, Yumi Yamaguchi-Kabata, Shu Tadaka, Taku Obara, Eiji Hishimuma, Nariyasu Mano, Masaki Matsuura, Yuji Sato, Masateru Nakasone, Yohei Honkura, Jun Suzuki, Yukio Katori, Yoichi Kakuta, Atsushi Masamune, Yoko Aoki, Masaharu Nakayama, Shigeo Kure, Kengo Kinoshita, Nobuo Fuse, Masayuki Yamamoto

JMA journal　5　(2)　177-189　2022/04/15

DOI： 10.31662/jmaj.2021-0156 　

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Introduction: Pharmacogenomic (PGx) testing results provide valuable information on drug selection and appropriate dosing, maximization of efficacy, and minimization of adverse effects. Although the number of large-scale, next-generation-sequencing-based PGx studies has recently increased, little is known about the risks and benefits of returning PGx results to ostensibly healthy individuals in research settings. Methods: Single-nucleotide variants of three actionable PGx genes, namely, MT-RNR1, CYP2C19, and NUDT15, were returned to 161 participants in a population-based Tohoku Medical Megabank project. Informed consent was obtained from the participants after a seminar on the outline of this study. The results were sent by mail alongside sealed information letter intended for clinicians. As an exception, genetic counseling was performed for the MT-RNR1 m.1555A > G variant carriers by a medical geneticist, and consultation with an otolaryngologist was encouraged. Questionnaire surveys (QSs) were conducted five times to evaluate the participants' understanding of the topic, psychological impact, and attitude toward the study. Results: Whereas the majority of participants were unfamiliar with the term PGx, and none had undergone PGx testing before the study, more than 80% of the participants felt that they could acquire basic PGx knowledge sufficient to understand their genomic results and were satisfied with their potential benefit and use in future prescriptions. On the other hand, some felt that the PGx concepts or terminology was difficult to fully understand and suggested that in-person return of the results was desirable. Conclusions: These results collectively suggest possible benefits of returning preemptive PGx information to ostensibly healthy cohort participants in a research setting.
The characteristics of dysphagia and the incidence of pneumonia in Myotonic dystrophy type 1 patients especially concerning swallowing function evaluated by endoscopy. International-journal Peer-reviewed

Tomonori Kambayashi, Ai Hirano-Kawamoto, Toshiaki Takahashi, Sayaka Taniguchi, Masaru Yoshioka, Hiroyasu Tanaka, Hideki Oizumi, Tomoko Totsune, Saki Oshiro, Toru Baba, Atsushi Takeda, Takuma Hisaoka, Jun Ohta, Ryoukichi Ikeda, Jun Suzuki, Kengo Kato, Yukio Katori

Auris, nasus, larynx　49　(6)　1003-1008　2022/04/12

DOI： 10.1016/j.anl.2022.04.003 　

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OBJECTIVE: The objectives of the study were to clarify the characteristics of dysphagia and the incidence of pneumonia in Myotonic dystrophy type 1 (DM1) patients, and to investigate the relationship between the development of pneumonia and the DM1 patient's background, especially concerning swallowing function evaluated by endoscopy. METHODS: The subjects were 88 DM1 patients who underwent swallowing function evaluation. The severity of disease in DM1patients was assessed based on the muscular impairment rating scale (MIRS), and the number of CTG repeats. Patients were divided into two groups; those who developed aspiration pneumonia within two years after swallowing assessment and those who did not develop aspiration pneumonia. Swallowing function was assessed using the food intake level scale (FILS), repetitive saliva swallowing test (RSST), the modified water swallowing test (MWST), and the Hyodo score. RESULTS: Onset of pneumonia within two years of assessment was observed in 22 cases (25%). Age, FILS, and Hyodo score were significantly different between pneumonia and non-pneumonia groups. There was a significant difference in swallowing function tests such as FILS, RSST, and Hyodo score between males and females. The Hyodo score cutoff value for predicting pneumonia within two years was determined by ROC analysis. A cutoff value of 6 was found to have a sensitivity of 0.545 and a specificity of 0.833 (area under the curve=0.722). CONCLUSION: It is important to evaluate the swallowing function of DM1 patients by endoscopy to prevent aspiration pneumonia. In addition, male patients are more likely to deteriorate in swallowing function and should be carefully monitored.
Paranasal sinus actinomycosis treated with a combination of surgery and long-term low-dose macrolide. International-journal

Yuki Numano, Kazuhiro Nomura, Mika Watanabe, Mitsuru Sugawara, Tomotaka Hemmi, Jun Suzuki, Risako Kakuta, Yukio Katori

Ear, nose, & throat journal　1455613221092208-1455613221092208　2022/04/09

DOI： 10.1177/01455613221092208 　

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Actinomycosis is a bacterial infection caused by actinomyces. Although almost 50% of cases are related to the head and neck region, those in the nose and paranasal sinuses (PNS) are rare. Actinomycosis of the PNS is presumed to be typically caused by dental caries, dental manipulation, and maxillofacial trauma, which facilitate the penetration of oral pathogens into the sinus, and should thus be treated by the combination of surgical removal and potent antibiotics for at least two months. The current use of these antibiotics might be redundant, considering the nature of actinomycosis of the PNS, which does not invade the mucosal surface. We herein report a 67-year-old female treated with endoscopic sinus surgery (ESS) and diagnosed with actinomycosis of the PNS by pathological findings. She had no history of dental impairment or treatment. She was given routine perioperative prophylactic antibiotics (cefazolin) during the surgery, followed by low-dose clarithromycin. The mucosa of the PNS normalized without any discharge by three months after the operation. The patient is a valuable example that should prompt reconsideration of the commonly accepted pathogenesis and treatment of actinomycosis of the PNS.
Effectiveness of mRNA COVID-19 Vaccines in Japan During the Nationwide Pandemic of the Delta Variant. Peer-reviewed

Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Noriko Sugawara, Kaoru Igarashi, Motoo Fujita, Shigeo Kure, Shin Takayama, Michiaki Abe, Akiko Kikuchi, Kota Ishizawa, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tadashi Ishii

The Tohoku journal of experimental medicine　257　(1)　1-6　2022/03/31

DOI： 10.1620/tjem.2022.J012 　

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The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remained a major global health concern in 2021. To suppress the spread of infection, mass vaccinations have been performed across countries worldwide. In Japan, vaccinations of the first and second doses for most of the nation were performed during the nationwide outbreak of the B.1.617.2 (Delta) variant with the L452R spike protein mutation, and the effectiveness of the vaccinations to suppress the spread of COVID-19 among the people in Japan remains uncertain. In this study, adults aged ≥18 years, who were in contact with patients with COVID-19 and underwent nasopharyngeal swab reverse transcription-polymerase chain reaction (RT-PCR) tests during August and September 2021 at a mass screening test center in Japan, were enrolled. In this period, more than 95% of the COVID-19 infections were reportedly caused by the Delta variant. As a result, a total of 784 adults with recent contact history, including 231 (29.5%) RT-PCR test-positive cases, were enrolled. The test positivity rate was lower in individuals who had been vaccinated twice than in unvaccinated individuals (12.5% vs. 39.0%, p < 0.0001), with the risk ratio of 0.32 (95% confidence interval 0.23-0.46). The vaccine effectiveness was the highest between 7-90 days after the second vaccine dose. In conclusion, two doses of mRNA COVID-19 vaccines effectively suppressed transmission in Japan during the nationwide pandemic of the Delta variant, estimated to have prevented 50-80% of the infection.
Effect of treatments for head and neck cancer on sinus shadow on computed tomography. International-journal Peer-reviewed

Tomotaka Hemmi, Jun Suzuki, Ryo Ishii, Ryoukichi Ikeda, Yuta Kobayashi, Hiroyuki Ikushima, Kazuhiro Nomura, Mitsuru Sugawara, Akira Ohkoshi, Yukio Katori

Auris, nasus, larynx　49　(6)　1019-1026　2022/03/24

DOI： 10.1016/j.anl.2022.03.020 　

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OBJECTIVE: Head and neck surgeries may cause changes in the nasal airflow, and radiotherapy irreversibly damages paranasal sinus epithelial cells. Some chemotherapeutic drugs have been reported to negatively affect airway ciliary activity in mice, and chronic rhinosinusitis could be an adverse effect of head and neck cancer (HNC) treatment. To evaluate whether HNC treatment is a risk factor for developing sinonasal mucosal thickening that may reflect paranasal sinus inflammation, we compared pre- and post-treatment paranasal sinus computed tomography (CT) images of patients treated for HNC at a single university hospital. METHODS: The patients who received curative treatment for HNC (oral, pharyngeal, and laryngeal cancers) and started receiving first-line therapy between January 2015 and December 2019 were included. Data on age, sex, primary lesion, clinical stage, treatment, smoking history, drinking history, comorbidities (diabetes and chronic lung disease), and pre- and post-treatment (three months and one year after the final treatment) paranasal sinus CT images were analyzed from medical records. Pre- and post-treatment paranasal sinus CT images were scored using the Lund-Mackay (LM) staging system. RESULTS: In total, 245 patients participated in this study. Three months after the final treatment, 80.4% of patients had no change in their total LM scores (p=0.621). Almost 80% of patients who underwent total laryngectomy also had no change in their total LM scores (p=0.833). One-third of patients with nasopharyngeal cancer (NPC) had worse LM scores after treatment (5/15), although no significant difference was observed (p=0.171). None of the various factors collected were significantly related to changes in LM scores three months after the completion of treatment. One year after the final treatment, 211 patients were included and no significant changes in the pre-and post-LM scores were observed in the same analyses, while changes in LM scores were significantly different between T categories (T1-2 vs. T3-4) (p=0.020). CONCLUSION: We found no significant changes in the LM scores after HNC treatment in all the patients, which implies that HNC treatment may not be an apparent risk factor for sinonasal mucosal inflammation.
Long-term outcomes after surgery to prevent aspiration for patients with amyotrophic lateral sclerosis. International-journal Peer-reviewed

Temma Soga, Naoki Suzuki, Kengo Kato, Ai Kawamoto-Hirano, Yuko Kawauchi, Rumiko Izumi, Masaya Toyoshima, Shio Mitsuzawa, Tomomi Shijo, Kensuke Ikeda, Hitoshi Warita, Yukio Katori, Masashi Aoki, Masaaki Kato

BMC neurology　22　(1)　94-94　2022/03/16

DOI： 10.1186/s12883-022-02619-z 　

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BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons selectively. In particular, weakness in respiratory and swallowing muscles occasionally causes aspiration pneumonia and choking, which can be lethal. Surgery to prevent aspiration, which separates the trachea and esophagus, can reduce the associated risks. Central-part laryngectomy (CPL) is a relatively minimally invasive surgery to prevent aspiration. No studies have been conducted on the long-term outcomes of surgery to prevent aspiration in patients with ALS. This case series aimed to determine the long-term outcomes of surgery to prevent aspiration and the use of a continuous low-pressure aspirator in patients with ALS by evaluating the frequency of intratracheal sputum suctions performed per day, intra- and postoperative complications, oral intake data, and satisfaction of patients and their primary caregiver to predict improvement in patients' quality of life (QOL). METHODS: We report a case series of six patients with ALS who underwent CPL along with tracheostomy to prevent aspiration between January 2015 and November 2018. We evaluated their pre- and postoperative status and administered questionnaires at the time of last admission to the patients and their primary caregivers. RESULTS: The mean follow-up period after CPL was 33.5 months. Aerophagia was a common postoperative complication. The use of a continuous low-pressure aspirator resulted in reduced frequency of intratracheal sputum suctions. All cases avoided aspiration pneumonia. Oral intake was continued for 2-4 years after the tracheostomy and CPL. The satisfaction levels of the patient and primary caregiver were high. CONCLUSION: Our case series suggests that the use of a continuous low-pressure aspirator in patients undergoing CPL improves oral intake and reduces the frequency of intratracheal sputum suctions, which improves the QOL of patients with ALS and their families and caregivers. CPL and continuous low-pressure aspiration should be considered as a management option for ALS with significant bulbar and respiratory muscle weakness/dysfunction.
Growth in fetuses of the constrictor pharyngis superior with special reference to its meeting with the buccinator: an embryological basis of adult variations in palatopharyngeal anatomy Peer-reviewed

Zhe-Wu Jin, Ji Hyun Kim, Masahito Yamamoto, Yukio Katori, Hiroshi Abe, Gen Murakami, Shin-ichi Abe

Surgical and Radiologic Anatomy　2022/02/28
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s00276-022-02907-w 　

ISSN： 0930-1038

eISSN： 1279-8517
Malignant otitis externa presenting cerebral infarction from pseudoaneurysm: A case report and a review of the literature International-journal Peer-reviewed

Yasutoshi Koshiba, Ryoukichi Ikeda, Jun Suzuki, Yohei Honkura, Yukino Funayama, Kensuke Ikeda, Hitoshi Warita, Masashi Aoki, Tetsuaki Kawase, Yukio Katori

Clinical Caes Reports　10　(2)　e05276　2022/02/16

DOI： 10.1002/ccr3.5276 　

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Chronic renal failure and diabetes mellitus could also be risk factors of pseudoaneurysm of the internal carotid artery (ICA) due to malignant otitis externa (MOE). Although pseudoaneurysm of the ICA is a rarely encountered disease, it should always be taken into consideration when treating patients of MOE.
Perfusion defects in non-enlarged metastatic lymph nodes using vessel wall magnetic resonance imaging: Detection performance and diagnostic value International-journal Peer-reviewed

Maya Sakamoto, Ikuho Kojima, Masahiro Iikubo, Koichi Ito, Takafumi Aoki, Shiro Mori, Takenori Ogawa, Yukio Katori, Takaki Murata, Daisuke Ito, Tetsuya Kodama

Clin Exp Metastasis .　2022/02/04

DOI： 10.1007/s10585-022-10147-w 　

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A perfusion defect (PD) in non-enlarged lymph nodes (LNs) of oral squamous cell carcinoma (OSCC) is the most reliable radiological criterion for the diagnosis of metastasis. However, conventional contrast-enhanced (CE) T1 weighted images using turbo spin echo (TSE) sequence is limited in detecting PD in non-enlarged LNs due to flow artifacts from cervical blood vessels. Vessel wall (VW) MR imaging with blood vessel flow suppression and high spatial resolution may provide new insights into the detection of PD. However, there are no reports in the literature on the usefulness of VW MR imaging for the diagnosis of LN metastasis. It is demonstrated that PD of non-enlarged LNs in CE VR MR imaging of OSCC patients is useful for the diagnosis of metastatic LNs. VW MR imaging was significantly more sensitive in detecting PD of non-enlarged metastatic LNs than conventional TSE imaging on visual evaluation. Furthermore, it was found that the image contrast between PD and surrounding intranodal tissue in CE VW MR images was higher than that in conventional CE TSE images. In the correlation between imaging and histopathological findings of metastatic LNs, all LNs that exhibited PD on CE VW MR images were at an advanced histopathological metastatic stage. The pathology of PD was necrotic tissue with keratinization. The results indicated that PD in CE VW imaging is useful in diagnosing non-enlarged LNs at an advanced metastasis stage. The addition of VW MR imaging to conventional MR examination achieves higher diagnostic performance for non-enlarged metastatic LNs.
Patulous Eustachian Tube Patients With Oculopharyngeal Muscular Dystrophy International-journal Peer-reviewed

Kento Ishigakii, Ryoukichi Ikeda, Jun Suzuki, Ai Hirano-Kawamoto, Jun Ohta, Kengo Kato, Rumiko Izumi, Naoki Suzuki, Masashi Aoki, Tetsuaki Kawase, Yukio Katori

Otol Neurotol .　43　(4)　e442-e445　2022/02/03

DOI： 10.1097/MAO.0000000000003494 　

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OBJECTIVES: To describe cases of patulous Eustachian tube (PET) or patent ET conditions in oculopharyngeal muscular dystrophy (OPMD). PATIENTS: Four cases of PET or patent ET conditions with OPMD. MAIN OUTCOME MEASURES: Clinical case records, objective ET function tests (tubo-tympano-aerodynamic graphy and sonotubometry), and swallowing function (videoendoscopic examination and Food Intake Level Scale) were analyzed. RESULTS: Two cases of definite PET, one case of possible PET, and one case lacking aural symptoms with findings of patent ET. All patients have ptosis, and three cases have dysphagia. Body mass index indicated that three cases were underweight. Magnetic resonance imaging in case 4 showed atrophy and fat replacement of palatine and masticatory muscles. CONCLUSIONS: It is important to consider PET or patent ET conditions when OPMD patients describe aural symptoms.
Enlargement of Eustachian Tube Lumen in Patulous Eustachian Tube Patients Compared to that by Aging. International-journal Peer-reviewed

Ryoukichi Ikeda, Yusuke Kusano, Yoshinobu Kawamura, Hidetoshi Oshima, Toshiaki Kikuchi, Tetsuaki Kawase, Yukio Katori, Toshimitsu Kobayashi

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology　43　(4)　e446-e453　2022/01/27

DOI： 10.1097/MAO.0000000000003482 　

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OBJECTIVE: To evaluate the Eustachian tube (ET) dimensions in patulous ET (PET) patients compared with that by aging using sitting 3D computed tomography (CT). STUDY DESIGN: Retrospective study. SETTING: Tertiary referral center. SUBJECTS AND METHODS: A retrospective survey of medical records in Sen-En Rifu Hospital identified 105 ears of 76 PET patients and 65 ears of 34 patients without ET dysfunction findings (non-PET). Subjects in both PET and non-PET groups were then divided into two age groups. Groups A and C defined as non-PET and PET subjects respectively, who were under the age of 60 years, while Groups B and D defined of non-PET and PET subjects respectively, who were 60 years and above. 3D CT (Accuitomo; Morita, Kyoto, Japan) was performed on all subjects in the sitting position. The ET lumen from the ET pharyngeal orifice to 15 mm was analyzed. RESULTS: No significant difference in the ET lumen near the pharyngeal orifice was found between Group A and C; however, there was a significant difference in the ET at points lateral to the pharyngeal orifice. The ET lumen was significantly larger at the site close to the pharyngeal orifice in Group B as compared to that of Group A. For the two groups of PET classified according to the size of the pharyngeal orifice and area close to the isthmus, age was only significantly different between two groups of pharyngeal orifice. On the contrary, sonotumometry and Ohta method were significantly different between the two groups of the area close to the isthmus. CONCLUSION: The lumen of the ET is enlarged in both PET and aging. However, the responsible site was found to be different. While the enlargement of the ET lumen in 60 years and above subjects without PET mainly occurred near the pharyngeal orifice of the ET, it was near the isthmus in under 60 years PET patients. Further study of possible clinical implications of these findings as well as treatment strategy are required.
Hearing Outcomes of Transmastoid Plugging for Superior Canal Dehiscence Syndrome by Underwater Endoscopic Surgery International-journal Peer-reviewed

Yoshinobu Kawamura, Daisuke Yamauchi, Toshimitsu Kobayashi, Ryoukichi Ikeda, Tetsuaki Kawase, Yukio Katori

Otology & Neurotology　Publish Ahead of Print　(3)　368-375　2022/01/06
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI： 10.1097/mao.0000000000003461 　

ISSN： 1531-7129

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OBJECTIVE: To investigate the influence on hearing of transmastoid plugging of the superior semicircular canal accompanied with membranous superior canal transection by underwater endoscopic ear surgery (UWEES) for the superior semicircular canal dehiscence syndrome. STUDY DESIGN: Retrospective case review. SETTING: Tertiary referral center. PATIENTS: Seven patients underwent plugging with membranous superior canal transection with UWEES from 2017 to 2019. INTERVENTION: Bone conduction (BC) thresholds (250, 500, 1000, 2000, 4000 Hz) were repetitively examined in early postoperative period. MAIN OUTCOME MEASURES: Subjective symptoms and pure-tone audiometry. RESULTS: Transient BC threshold increase was detected in all cases in early postoperative period and hearing levels were ameliorated in 1 to 2 months. The mean maximum BC threshold elevations (dB) during the early postoperative period (within 1 mo) and the postoperative stable hearing period (after 2 mo) were 18.6 and 2.9 at 250 Hz, 24.3 and 8.6 at 500 Hz, 26.4 and 8.6 at 1000 Hz, 28.6 and 7.1 at 2000 Hz, and 30.0 and 0.8 (except for scale-out cases) at 4000 Hz. respectively. The mean maximum BC thresholds in the early period were significantly elevated compared with those in the stable period at each frequency (p < 0.01). CONCLUSIONS: Hearing outcomes of transmastoid plugging with transection of the membranous superior canal by using UWEES were found favorable in a long-term follow-up. However, it caused transient reversible hearing loss in all cases. The BC increase in early postoperative period may not cause permanent hearing loss but improvement for the surgical technique may still be necessary.
Different contra-sound effects between noise and music stimuli seen in N1m and psychophysical responses International-journal Peer-reviewed

Masayuki Shirakura, Tetsuaki Kawase, Akitake Kanno, Jun Ohta, Nobukazu Nakasato, Ryuta Kawashima, Yukio Katori

PLOS ONE　16　(12)　e0261637-e0261637　2021/12/20
Publisher: Public Library of Science (PLoS)
DOI： 10.1371/journal.pone.0261637 　

eISSN： 1932-6203

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Auditory-evoked responses can be affected by the sound presented to the contralateral ear. The different contra-sound effects between noise and music stimuli on N1m responses of auditory-evoked fields and those on psychophysical response were examined in 12 and 15 subjects, respectively. In the magnetoencephalographic study, the stimulus to elicit the N1m response was a tone burst of 500 ms duration at a frequency of 250 Hz, presented at a level of 70 dB, and white noise filtered with high-pass filter at 2000 Hz and music stimuli filtered with high-pass filter at 2000 Hz were used as contralateral noise. The contralateral stimuli (noise or music) were presented in 10 dB steps from 80 dB to 30 dB. Subjects were instructed to focus their attention to the left ear and to press the response button each time they heard burst stimuli presented to the left ear. In the psychophysical study, the effects of contralateral sound presentation on the response time for detection of the probe sound of a 250 Hz tone burst presented at a level of 70 dB were examined for the same contra-noise and contra-music used in the magnetoencephalographic study. The amplitude reduction and latency delay of N1m caused by contra-music stimuli were significantly larger than those by contra-noise stimuli in bilateral hemisphere, even for low level of contra-music near the psychophysical threshold. Moreover, this larger suppressive effect induced by contra-music effects was also observed psychophysically; i.e., the change in response time for detection of the probe sound was significantly longer by adding contralateral music stimuli than by adding contra-noise stimuli. Regarding differences in effect between contra-music and contra-noise, differences in the degree of saliency may be responsible for their different abilities to disturb auditory attention to the probe sound, but further investigation is required to confirm this hypothesis.
Design of an Artificial Tongue Driven by Shape Memory Alloy Fibers Peer-reviewed

Yasuyuki Shiraishi, Akihiro Yamada, Genta Sahara, Tomoyuki Yambe, Kengo Kato, Jun Ohta, Yukio Katori, Dai Homma

2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)　1573-1576　2021/11/01
Publisher: IEEE
DOI： 10.1109/embc46164.2021.9630283 　

ISSN： 1557-170X
Serum selenium predicts achievement of full-dose cisplatin in concurrent chemoradiotherapy for locally advanced head and neck squamous cell carcinoma: A prospective, observational study Peer-reviewed

Akira Ohkoshi, Ryo Ishii, Shun Wakamori, Yuki Nakayama, Takuya Yoshida, Kenjiro Higashi, Ayako Nakanome, Takenori Ogawa, Yukio Katori

Oral Oncology　121　105475-105475　2021/10
Publisher: Elsevier BV
DOI： 10.1016/j.oraloncology.2021.105475 　

ISSN： 1368-8375

eISSN： 1879-0593
Changes in tongue pressure and dysphagia at oral cancer patients by palatal augmentation prosthesis International-journal Peer-reviewed

Izumita Kuniyuki, Takuma Hisaoka, Ryoukichi Ikeda, Jun Suzuki, Naoko Sato, Ryo Tagaino, Tomonori Kambayashi, Ai Hirano‐Kawamoto, Jun Ohta, Akira Ohkoshi, Ryo Ishii, Naru Shitraishi, Kengo Kato, Shigeto Koyama, Keiichi Sasaki, Yukio Katori

Cancer Reports　5　(7)　e1516　2021/09/02
Publisher: Wiley
DOI： 10.1002/cnr2.1516 　

ISSN： 2573-8348

eISSN： 2573-8348

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BACKGROUND: The palatal augmentation prosthesis (PAP) is an intraoral prosthesis used in the treatment of dysphagia. AIM: The objective of the study is to examine the effect of PAP using tongue pressure and the Videofluoroscopic Dysphagia Scale (VDS) to understand the precise mechanism for improvement in swallowing function with PAP for oral cancer at retrospective survey. METHODS AND RESULTS: Fifteen patients were provided PAPs. Tongue pressure and VDS were evaluated with and without PAP. After intervention with PAP, tongue pressure significantly increased as compared to when without PAP (p < .05). The total mean VDS score with PAP was found to have significantly improved (p < .05). The mean VDS score of the oral phase also significantly improved with the PAP compared to without the PAP group (p < .05). Significant differences (p < .01) were found in each category, such as tongue to palate contact and pyriform sinus residue. CONCLUSION: PAP can improve tongue pressure, tongue to palate contact, and pyriform sinus residue.
Buried oropharyngeal metal mesh foreign bodies in an infant Peer-reviewed

Shotaro Koizumi, Jun Suzuki, Yohei Honkura, Kenichi Watanabe, Yukio Katori

Otolaryngology Case Reports　20　(100317)　2021/09

DOI： 10.1016/j.xocr.2021.100317 　

eISSN： 2468-5488
The geriatric-8 screening tool for predicting complications in older adults after surgery for locally advanced head and neck cancer with free flap reconstruction

Yuki Nakayama, Akira Ohkoshi, Ryo Ishii, Kenjiro Higashi, Ayako Nakanome, Takenori Ogawa, Yukio Katori

European Archives of Oto-Rhino-Laryngology　2021/08/19
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s00405-021-07038-3 　

ISSN： 0937-4477

eISSN： 1434-4726
Characteristics of fish-bone foreign bodies in the upper aero-digestive tract: The importance of identifying the species of fish

Tadahisa Shishido, Jun Suzuki, Ryoukichi Ikeda, Yuta Kobayashi, Yukio Katori

PLOS ONE　16　(8)　e0255947-e0255947　2021/08/17
Publisher: Public Library of Science (PLoS)
DOI： 10.1371/journal.pone.0255947 　

eISSN： 1932-6203

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<sec id="sec001"> <title>Background</title> Fish bones are common foreign bodies in the upper aero-digestive tract, but their clinical features in relation to fish species have not been confirmed. We aimed to clarify the clinical characteristics of fish-bone foreign bodies and their location and removal methods depending on the fish species. </sec> <sec id="sec002"> <title>Study design</title> Retrospective, observational, monocentric study. </sec> <sec id="sec003"> <title>Methods</title> From October 2015 to May 2020, 368 patients visited the Department of Otolaryngology-Head and Neck Surgery at Tohoku University Hospital complaining of dysphagia, sore throat, or pharyngeal discomfort after eating fish. We analyzed the patients’ sex and age distribution, foreign-body location, type of the fish, and the techniques used for removing the foreign body. </sec> <sec id="sec004"> <title>Results</title> Fish bones were confirmed in the upper aero-digestive tract in 270 cases (73.4%), of which 236 (87.4%) involved fish-bone foreign bodies in the mesopharynx. The most frequently involved site was the palatine tonsil (n = 170). Eel was the most frequently observed fish species (n = 39), followed by mackerel (n = 33), salmon (n = 33), horse mackerel (n = 30), and flounder (n = 30). Among the 240 cases in which the bones did not spontaneously dislocate, 109 (45.4%) were treated by endoscopic removal (103 cases) or surgery (6 cases). In pediatric cases (<12 years old), almost all fish bones were found in the mesopharynx (138/139, 99.3%), and 31 cases (22.3%) required endoscopic removal. Flounder fish bones were often lodged in the hypopharynx and esophagus (9/30, 30%), hindering spontaneous dislocation and frequently necessitating endoscopic or surgical removal (19/29, 65.5%). </sec> <sec id="sec005"> <title>Conclusion</title> The characteristics of fish-bone foreign bodies differed depending on the fish species. Flounder bones were often stuck in the hypopharynx and esophagus and were likely to require more invasive removal methods. Confirming the species of the fish could facilitate appropriate diagnosis and treatment of fish-bone foreign bodies. </sec>
Characteristics of aspiration pneumonia patients in acute care hospitals: A multicenter, retrospective survey in Northern Japan International-journal Peer-reviewed

Jun Suzuki, Ryoukichi Ikeda, Kengo Kato, Risako Kakuta, Yuta Kobayashi, Akira Ohkoshi, Ryo Ishii, Ai Hirano-Kawamoto, Jun Ohta, Rei Kawata, Tomonori Kanbayashi, Masaki Hatano, Tadahisa Shishido, Yuya Miyakura, Kento Ishigaki, Yasunari Yamauchi, Miho Nakazumi, Takuya Endo, Hiroki Tozuka, Shiori Kitaya, Yuki Numano, Shotaro Koizumi, Yutaro Saito, Mutsuki Unuma, Ken Hashimoto, Eiichi Ishida, Toshiaki Kikuchi, Takayuki Kudo, Kenichi Watanabe, Masaki Ogura, Masaru Tateda, Takatsuna Sasaki, Nobuo Ohta, Tatsuma Okazaki, Yukio Katori

PLOS ONE　16　(7)　e0254261-e0254261　2021/07/30
Publisher: Public Library of Science (PLoS)
DOI： 10.1371/journal.pone.0254261 　

eISSN： 1932-6203

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<sec id="sec001"> <title>Background</title> Pneumonia is a common cause of illness and death of the elderly in Japan. Its prevalence is escalating globally with the aging of population. To describe the latest trends in pneumonia hospitalizations, especially aspiration pneumonia (AP) cases, we assessed the clinical records of pneumonia patients admitted to core acute care hospitals in Miyagi prefecture, Japan. </sec> <sec id="sec002"> <title>Methods</title> A retrospective multi-institutional joint research was conducted for hospitalized pneumonia patients aged ≥20 years from January 2019 to December 2019. Clinical data of patients were collected from the medical records of eight acute care hospitals. </sec> <sec id="sec003"> <title>Results</title> Out of the 1,800 patients included in this study, 79% of the hospitalized pneumonia patients were aged above 70 years. The most common age group was in the 80s. The ratio of AP to total pneumonia cases increased with age, and 692 out of 1,800 patients had AP. In univariate analysis, these patients had significantly older ages, lower body mass index (BMI), a lower ratio of normal diet intake and homestay before hospitalization, along with more AP recurrences and comorbidities. During hospitalization, AP patients had extended fasting periods, more swallowing assessments and interventions, longer hospitalization, and higher in-hospital mortality rate than non-AP patients. A total of 7% and 2% AP patients underwent video endoscopy and video fluorography respectively. In multivariate analysis, lower BMI, lower C-reactive protein, a lower ratio of homestay before hospitalization, a higher complication rate of cerebrovascular disease, dementia, and neuromuscular disease were noted as a characteristic of AP patients. Swallowing interventions were performed for 51% of the AP patients who had been hospitalized for more than two weeks. In univariate analysis, swallowing intervention improved in-hospital mortality. Lower AP recurrence before hospitalization and a lower ratio of homestay before hospitalization were indicated as characteristics of AP patients of the swallowing intervention group from multivariate analysis. Change in dietary pattern from normal to modified diet was observed more frequently in the swallowing intervention group. </sec> <sec id="sec004"> <title>Conclusion</title> AP accounts for 38.4% of all pneumonia cases in acute care hospitals in Northern Japan. The use of swallowing evaluations and interventions, which may reduce the risk of dysphagia and may associate with lowering mortality in AP patients, is still not widespread. </sec>
Discriminatory Value of Self-reported Olfactory Dysfunction in the Prediction of Coronavirus Disease 2019. Peer-reviewed

Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Shigeo Kure, Kaoru Igarashi, Motoo Fujita, Shin Takayama, Michiaki Abe, Akiko Kikuchi, Junichi Tanaka, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tadashi Ishii

Internal medicine (Tokyo, Japan)　60　(18)　2905-2910　2021/07/10
Publisher: Japanese Society of Internal Medicine
DOI： 10.2169/internalmedicine.7238-21 　

ISSN： 0918-2918

eISSN： 1349-7235

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Objective Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), remains the world's largest public health concern in 2021. A history of close contact with infectious patients is a factor that predicts a positive SARS-CoV-2 test result. Meanwhile, the precise predictive value of symptoms suggestive of COVID-19 has not been fully elucidated. This study aimed to clarify the predictive and discriminatory value of each clinical symptom suggestive of COVID-19. Methods This study enrolled participants who were tested for SARS-CoV-2 by reverse transcription polymerase chain reaction using a nasopharyngeal swab between November 2020 and January 2021. All enrolled patients were evaluated for data regarding the presence and closeness of contact with infectious patients and comprehensive clinical features (i.e., fever, cough, dyspnea, fatigue, dysosmia, and dysgeusia). Results Among the 1,744 tested participants, 144 tested positive for SARS-CoV-2. In the test-positive group, self-reported cough, fatigue, dysosmia, and dysgeusia were significant predictors of COVID-19, independent from a history of close contact. In particular, the presence of dysosmia was the strongest predictor of COVID-19 in both univariate and multivariate analyses. Among the 42 patients with self-reported dysosmia, 25 (59.5%) were SARS-CoV-2 test-positive. Self-reported dysosmia was reported by 25 (17.4%) of the 144 patients who tested positive for SARS-CoV-2, and 15 (60.0%) of the 25 COVID-19 patients with dysosmia had accompanying dysgeusia. Conclusion The presence of dysosmia was reported by 10-25% of patients with COVID-19, and is a significant predictor of COVID-19 infection, independent from a history of close contact.
Fetal development of the carotid canal with special reference to a contribution of the sphenoid bone and pharyngotympanic tube. International-journal Peer-reviewed

Yohei Honkura, Masahito Yamamoto, José Francisco Rodríguez-Vázquez, Gen Murakam, Hiroshi Abe, Shin-Ichi Abe, Yukio Katori

Anatomy & cell biology　54　(2)　259-269　2021/06/30

DOI： 10.5115/acb.20.310 　

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The bony carotid canal is a tube-like bone with a rough surface in contrast to smooth surfaces of the other parts of the temporal bone petrosal portion (petrosa): it takes an impression of the additional, out-sourcing product. No study had been conducted to evaluate a contribution of the adjacent sphenoid and pharyngotympanic tube (PTT) to the carotid canal. We examined sagittal and horizontal histological sections of hemi-heads from 37 human fetuses at 10 to 37 weeks. At 10 to 18 weeks, the future carotid canal was identified as a wide loose space between the cartilaginous cochlea and the ossified or cartilaginous sphenoid elements (ala temporalis and pterygoid). A linear mesenchymal condensation extending between the cochlear wall and ala temporalis suggested the future antero-inferior margin of the carotid canal. This delineation was more clearly identified in later stages. After 25 weeks, 1) the growing pterygoid pushed the PTT upward and, in turn, the PTT pushed the internal carotid artery (ICA) upward toward the petrosa: 2) a membranous ossification occurs in the dense mesenchymal tissue, the latter of which took an appearance of an anterior process of the petrosa; 3) the bony process of the petrosa involved the ICA inside or posteriorly. The bony carotid canal was made with membranous ossification in the dense mesenchymal tissue between the petrosa and sphenoid. The mother tissue was detached from the sphenoid by the PTT. The ossification of the septum between the ICA and tympanic cavity seemed to continue after birth.
Underwater Endoscopic Ear Surgery for Closure of Cholesteatomatous Labyrinthine Fistula With Preservation of Auditory Function. International-journal Peer-reviewed

Daisuke Yamauchi, Yohei Honkura, Yoshinobu Kawamura, Yuichi Shimizu, Tomoki Sunose, Yosuke Hara, Jun Ohta, Jun Suzuki, Tetsuaki Kawase, Yukio Katori

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology　Publish Ahead of Print　(10)　e1669-e1676　2021/06/25
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI： 10.1097/MAO.0000000000003241 　

ISSN： 1531-7129

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OBJECTIVE: To analyze the outcomes of the underwater endoscopic ear surgery (UWEES) technique for closure of cholesteatomatous labyrinthine fistula (LF) with preservation of auditory function. STUDY DESIGN: Retrospective case review study. SETTING: Tertiary referral center. PATIENTS: A total of 12 patients with cholesteatomatous LF. INTERVENTION: Surgical method of closure using UWEES for cholesteatomatous LF to minimize inner ear damage. Artificial cerebrospinal fluid (CSF) was used as the perfusate, except for earlier cases when saline was employed. MAIN OUTCOME MEASURES: Comparison of bone conductance hearing level (BCHL) before and after surgery. A change of BCHL less than 10 dB was defined as successful preservation of bone conductance hearing. RESULTS: All cases of LF were treated successfully by closure using the UWEES technique. Seven cases were type I, one was type IIa, and four were type III according to the Milewski and Dornhoffer classification of LF. The average LF size was 3.1 mm (1-7 mm). Eleven patients were evaluated and their bone conductance hearing was well preserved in all of them (11/11). One patient was too young for preoperative evaluation of BCHL, but hearing preservation was verified 2 years later at the age of 6 years. Remarkably, none of the patients complained of vertigo, except for only a slight manifestation on postoperative day 1. CONCLUSION: The UWEES technique was effective for closure of cholesteatomatous LF with preservation of auditory function.
Clinical Factors Associated With the Outcomes of Long-Term Middle Ear Ventilation Tube Insertion in Pediatric Patients. International-journal

Shunsuke Takai, Kazuhiro Nomura, Kiyoshi Oda, Daiki Ozawa, Mihoko Irimada, Ryoukichi Ikeda, Risako Kakuta, Yukio Katori, Kenji Ohyama

Ear, nose, & throat journal　1455613211026437-1455613211026437　2021/06/15

DOI： 10.1177/01455613211026437 　

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BACKGROUND: Ventilation tube (VT) insertion is the most common treatment for otitis media with effusion (OME). However, OME recurrence and persistent tympanic membrane (TM) perforation after VT removal are encountered in a certain percentage of such children. METHODS: This study was performed to determine the outcomes of children who underwent long-term VT insertion. A total of 326 ears from 192 patients were analyzed. The associations among the patient age, sex, history of OME, history of repeated acute otitis media, placement duration, whether the VT had been removed intentionally or spontaneously, and the outcome (persistent TM perforation or OME recurrence) were analyzed. The outcomes of multiple VT tube insertions were also reviewed. We also analyzed whether or not local or general anesthesia was associated with the early spontaneous extrusion of the VT. RESULT: The OME recurrence and TM perforation rates were 29% (96/326 sides) and 17% (57/326 sides), respectively, for first insertions. In addition, 96 (29%) sides underwent ≥2 insertions. The shorter the duration for which the VT was retained in the middle ear, the more significant the rate of increase in OME recurrence. The OME recurrence was observed more often when VT was spontaneously removed than when intentionally removed. The rate of persistent TM perforation was significantly associated with male sex. Persistent TM perforation was not observed in patients who underwent 4 or 5 insertions. The anesthesia method did not significantly influence the timing of spontaneous extrusion of VT. CONCLUSION: The retention period of VT should be at least 2 years, and VT removal at the age of 7 might be a viable strategy. Multiple VT insertions are recommended for patients with recurrent OME. Ventilation tube under local anesthesia is an effective option for tolerable children.
COVID-19 transmission in group living environments and households. International-journal Peer-reviewed

Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Shigeo Kure, Kaoru Igarashi, Shin Takayama, Michiaki Abe, Junichi Tanaka, Akiko Kikuchi, Ko Onodera, Tadashi Ishii

Scientific reports　11　(1)　11616-11616　2021/06/02

DOI： 10.1038/s41598-021-91220-4 　

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The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently the world's largest public health concern. This study evaluated COVID-19 transmission risks in people in group living environments. A total of 4550 individuals with a history of recent contact with patients at different places (dormitory/home/outside the residences) and levels (close/lower-risk) were tested for SARS-CoV-2 viral RNA using a nasopharyngeal swab test between July 2020 and May 2021. The test-positive rate was highest in individuals who had contact in dormitories (27.5%), but the rates were largely different between dormitories with different infrastructural or lifestyle features and infection control measures among residents. With appropriate infection control measures, the secondary transmission risk in dormitories was adequately suppressed. The household transmission rate (12.6%) was as high as that of close contact outside the residences (11.3%) and accounted for > 60% of the current rate of COVID-19 transmission among non-adults. Household transmission rates synchronized to local epidemics with changed local capacity of quarantining infectious patients. In conclusion, a group living environment is a significant risk factor of secondary transmission. Appropriate infection control measures and quarantine of infectious residents will decrease the risk of secondary transmission in group living environments.
Patulous Eustachian Tube Patients with Respiratory Fluctuation of Tympanic Membrane in Both Sitting and Supine Positions: A Sign of Severity of Disease? International-journal Peer-reviewed

Yusuke Kusano, Yoshinobu Kawamura, Ryoukichi Ikeda, Hidetoshi Oshima, Toshiaki Kikuchi, Tetsuaki Kawase, Yukio Katori, Toshimitsu Kobayashi

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology　42　(8)　e1058-e1061　2021/05/12

DOI： 10.1097/MAO.0000000000003190 　

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OBJECTIVE: The aim is to report four cases of patulous Eustachian tube (PET) patients with respiratory fluctuation of the tympanic membrane (TM) even in the supine position, and to examine the frequency and characteristics of such patients. PATIENTS: There were 195 ears (99 right ears and 96 left ears) from 146 cases (56 male and 90 female subjects aged 8-88, average 48.0 ± 18.9 yrs) diagnosed with definite PET by diagnostic criteria proposed by Japan Otologic Society (JOS) between January 2017 and December 2019 at Sen-En Rifu Hospital. Patients who presented with respiratory fluctuation of the TM in both the sitting and supine positions were examined. MAIN OUTCOME MEASURES: Clinical patient records, the severity of subjective symptoms (PET handicap inventory-10 [PHI-10]), objective ET function tests (tubo-tympano-aerodynamic graphy [TTAG] and sonotubometry), and sitting three-dimensional computed tomography (3-D CT) were analyzed. RESULTS: Six ears (3.1%) of four cases (2.7%) exhibited respiratory fluctuation of the TM, even in the supine position. In these six ears (four cases), the PHI-10 score ranged from 16 to 36 with three ears exhibiting PHI-10 score equal to or exceeding 26 (in the category of severe handicap). Sitting CT indicated the findings of completely open ET in only two ears. All ears but one were managed by conservative treatment. CONCLUSION: Respiratory fluctuation of the TM in both the sitting and supine positions was observed in 2.7% of the definite PET patients. Surprisingly, such findings can be an indication of neither the subjective nor objective severity of the disease. Therefore, even for PET patients with such findings, surgery should not be immediately proposed, but rather, conservative management should be undertaken first.
A Novel Mutation in LMX1B (p.Pro219Ala) Causes Focal Segmental Glomerulosclerosis with Alport Syndrome-like Phenotype. Peer-reviewed

Yuji Oe, Eikan Mishima, Takayasu Mori, Koji Okamoto, Yohei Honkura, Tasuku Nagasawa, Mai Yoshida, Hiroshi Sato, Jun Suzuki, Ryoukichi Ikeda, Eisei Sohara, Shinichi Uchida, Yukio Katori, Mariko Miyazaki

Internal medicine (Tokyo, Japan)　60　(18)　2991-2996　2021/04/05

DOI： 10.2169/internalmedicine.6987-20 　

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A 69-year-old woman presented with mild renal dysfunction, proteinuria, and sensorineural hearing loss. A renal biopsy showed focal segmental glomerulosclerosis with thinning of the glomerular basement membrane. There was a positive family history of end-stage kidney disease and hearing loss. Although Alport syndrome was suspected from these features, a genetic test using next-generation sequencer identified a novel missense mutation in LMX1B, c.655C>G: p. (Pro219Ala). In silico analyses predicted the pathogenicity of the mutation. Thus, the present case was diagnosed as LMX1B-associated nephropathy presenting with Alport syndrome-like phenotype, expanding the disease spectrum of LMX1B nephropathy.
Comparison of Magnetic Resonance Imaging and Computed Tomography in the Evaluation of the Olfactory Cleft and Ethmoidal Cells. International-journal Peer-reviewed

Tomotaka Hemmi, Kazuhiro Nomura, Jun Suzuki, Yuta Kobayashi, Risako Kakuta, Mitsuru Sugawara, Yukio Katori

The Journal of craniofacial surgery　32　(7)　2462-2464　2021/04/05

DOI： 10.1097/SCS.0000000000007657 　

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ABSTRACT: No study has examined whether magnetic resonance imaging (MRI) alone can be used for evaluating olfactory cleft and ethmoidal sinus in patients with olfactory disorders. Therefore, we analyzed the discrepancies between computed tomography (CT) and MRI in the imaging of the olfactory cleft and ethmoidal sinus. Patients who underwent CT and MRI within 30 days were evaluated. Age, sex, diagnosis, presence of bronchial asthma (BA), peripheral blood eosinophil percentage, and CT and MRI findings were retrospectively reviewed, and the sinuses were assessed on a scale of 0 to 3. Overall, 146 patients with 292 sinuses were enrolled. The ethmoid sinus score and the olfactory cleft score had 77.1% and 72.6% image similarity in CT and MRI. Sex and BA status were not associated with olfactory cleft score discrepancies (sex: P = 0.52, BA: P = 0.41). Magnetic resonance imaging scores tended to be rated higher than the CT scores as age increased, although this difference was not statistically significant (P = 0.09). The higher the peripheral blood eosinophil percentage, the more the magnitude by which the CT score tended to exceed the MRI score; however, this finding was also not statistically significant (P = 0.11). Magnetic resonance imaging scans should be limited to the evaluation of intracranial regions. Scans of olfactory cleft and ethmoid cells are not accurate for the assessment of olfactory dysfunction.
Impact of CAD/CAM mandibular reconstruction on chewing and swallowing function after surgery for locally advanced oral cancer: A retrospective study of 50 cases. International-journal Peer-reviewed

Akira Ohkoshi, Naoko Sato, Koreyuki Kurosawa, Hitoshi Miyashita, Ryo Ishii, Ayako Nakanome, Takenori Ogawa, Masahiro Tachi, Tetsu Takahashi, Yukio Katori

Auris, nasus, larynx　48　(5)　1007-1012　2021/04/03

DOI： 10.1016/j.anl.2021.03.014 　

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OBJECTIVE: Computer-aided design and computer-aided manufacturing (CAD/CAM) techniques are increasingly applied to mandibular reconstruction, but the superiority of this method in oral food intake has not been well established. Considering the extent of mandibular defects, this retrospective study was aimed to clarify the impact of CAD/CAM mandibular reconstruction on chewing and swallowing function after surgery for locally advanced oral cancer. MATERIALS AND METHODS: We performed a retrospective review of 50 patients who had undergone segmental mandibulectomy with free flap reconstruction for locally advanced oral cancer. The patients' Functional Oral Intake Scale scores were measured at 3 months after surgery, and possible contributing factors including CAD/CAM mandibular reconstruction and the extent of mandibular defects for oral food intake were subjected to univariate analysis and multivariate logistic regression analysis. RESULTS: Multivariate logistic regression analysis showed that CAD/CAM mandibular reconstruction was independently associated with good oral intake, whereas both anterior or extensive mandibular resection and glossectomy were also independently associated with poor oral intake after surgery. CONCLUSION: The present study showed the positive impact of CAD/CAM mandibular reconstruction on chewing and swallowing function after surgery for locally advanced oral cancer for the first time.
Use of the geriatric-8 screening tool to predict prognosis and complications in older adults with head and neck cancer: A prospective, observational study. International-journal Peer-reviewed

Ryo Ishii, Takenori Ogawa, Akira Ohkoshi, Ayako Nakanome, Masahiro Takahashi, Yukio Katori

Journal of geriatric oncology　12　(7)　1039-1043　2021/03/20

DOI： 10.1016/j.jgo.2021.03.008 　

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OBJECTIVES: To clarify the usefulness of geriatric assessment screening tools for predicting prognosis and complications in older adults with head and neck cancer (HNC). MATERIAL AND METHODS: The geriatric-8 (G8) screening tool was administered to 78 older adults with HNC at their first visit to the hospital before any treatments. The ability of the G8 to predict survival was evaluated by receiver operating characteristic (ROC) curve analysis and determining the cut-off value using Youden's Index. The G8 and other factors related to prognosis (age, performance status (PS), Charlson comorbidity index, number of oral medicines (polypharmacy), the controlling nutritional status (CONUT) score for biological nutrition status, and treatment intent (curative or palliative)) were validated by Cox proportional hazards regression analysis. The survival analysis was validated in a propensity score-weighting cohort to correct for confounding factors. Correlations between these factors and complications were examined using Fishers exact test. RESULTS: The G8 cut-off value for overall survival was 10.5 (area under the curve (AUC) 0.69; 95% confidence interval (CI) 0.56-0.82). In the propensity score-weighted cohort, on Cox proportional hazards regression analysis, the hazard ratio of an abnormal G8 (<11) was 3.70 [1.59-8.61 (p = 0.002)], and the hazard ratio of PS-abnormal (≥2) was 0.85 [0.09-7.60 (p = 0.88)]. Thirty-day mortality and all-complication rates were significantly higher in the G8-abnormal group. Neither major complications nor transfer to other institutions was correlated with an abnormal G8. CONCLUSION: The G8 was a strong prognostic factor and a possible predictor of complications in older adults with HNC.
Analysis of Dysphagia and Cough Strength in Patients with Unilateral Vocal Fold Paralysis. International-journal Peer-reviewed

Kazutaka Kashima, Kenichi Watanabe, Takeshi Sato, Yukio Katori

Dysphagia　2021/03/17

DOI： 10.1007/s00455-021-10274-8 　

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The association between swallowing function and cough strength in patients with unilateral vocal fold paralysis (UVFP) is unknown. We evaluated the relationship between voluntary cough strength and dysphagia among patients with UVFP (UVFP group) by comparing their data with that of corresponding healthy participants (healthy control [HC] group) in a prospective observational study. From February 1st, 2018 to March 30th, 2019, we recruited patients with a voice disorder due to UVFP, who were referred to our university hospital. Patients with a history of laryngeal surgery, vagal nerve paralysis, or cardiac and respiratory failure were excluded. Descriptive and clinical data regarding swallowing, voice, and cough peak flow (CPF) were collected as a measure of cough strength. The UVFP group comprised six women and seven men (median age, 68.0 years), and the HC group comprised six women and eight men (median age 65.5 years). The groups differed significantly in the Eating Assessment Tool (EAT)-10 scores and CPF rates (P < 0.001). Among patients with UVFP, 84.6% had an abnormal EAT-10 score of ≥ 3. Additionally, 16.7% of the patients exhibited liquid aspiration with contrast medium on a videofluorographic swallowing study (VFSS). There was no correlation between the CPF values, EAT-10 scores, or the VFSS results. Therefore, patients with severe UVFP, whose condition had been fixed, had difficulties when swallowing (85% of cases), and some even presented with aspiration on VFSS (20% of cases), while receiving a regular diet.
Loudness functions for patients with functional hearing loss. International-journal Peer-reviewed

Saori Shiraki, Takeshi Sato, Ryoukichi Ikeda, Jun Suzuki, Yohei Honkura, Shuichi Sakamoto, Yukio Katori, Tetsuaki Kawase

International journal of audiology　61　(1)　1-7　2021/02/15

DOI： 10.1080/14992027.2021.1881627 　

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OBJECTIVES: To compare the loudness functions (loudness ratings as a function of sound level) obtained from patients diagnosed as having functional hearing loss (FHL) with those for patients with sensorineural hearing loss (SNHL) and healthy volunteers. DESIGN: Loudness functions for a 1000 Hz tone for patients with FHL and SNHL were assessed based on the categorical loudness scaling method. The data were compared with control data obtained in our facilities. STUDY SAMPLE: 18 patients (33 ears) with FHL and 10 patients (19 ears) with SNHL. RESULTS: For patients with SNHL and healthy volunteers, loudness increased progressively with increasing sound level above the audiometric threshold, with no exceptions. However, for about 70% of the patients with FHL, a different type of loudness function was obtained; the thresholds determined from the loudness function, which were defined as the minimum sound levels at which loudness could be judged, were 10 dB or more lower than the audiometric threshold (>10 dB), and/or the loudness ratings were elevated for a sound at the audiometric threshold. CONCLUSIONS: The results support the hypothesis that patients with FHL often make threshold judgments based on a certain loudness.
Questionnaire survey on pharyngolaryngeal sensation evaluation regarding dysphagia in Japan. International-journal Peer-reviewed

Tomonori Kambayashi, Kengo Kato, Ryoukichi Ikeda, Jun Suzuki, Yohei Honkura, Ai Hirano-Kawamoto, Jun Ohta, Hitoshi Kagaya, Makoto Inoue, Masamitsu Hyodo, Koichi Omori, Atsushi Suehiro, Tatsuma Okazaki, Shin-Ichi Izumi, Shigeto Koyama, Keiichi Sasaki, Yoshihiko Kumai, Takaharu Nito, Shinichi Kuriyama, Takenori Ogawa, Yukio Katori

Auris, nasus, larynx　48　(4)　666-671　2021/02/14
Publisher: Elsevier BV
DOI： 10.1016/j.anl.2021.01.022 　

ISSN： 0385-8146

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OBJECTIVE: The objective is to conduct a questionnaire survey regarding pharyngolaryngeal sensation evaluation in dysphagia to understand the current situation in Japan. METHOD: The questionnaire was sent to the councilor of the Society of Swallowing and Dysphagia of Japan and the Japanese Society of Dysphagia Rehabilitation-Certified Clinician. The prospective questionnaire survey included the questions listed below: Q1: What do you think of the importance of pharyngolaryngeal sensory evaluation? Q2: Select one of the essential swallowing sensations. Q3: Select one of the following regarding the frequency of sensory examination of the larynx. Q4: Select the proportion of cases the sensory test results affect. Q5: As a pharyngolaryngeal sensory evaluation method in swallowing function evaluation, please fill in the table below for the frequency, difficulty, and effectiveness of the following tests, such as gag reflex, touching the larynx by endoscopy, touching the larynx by the probe with endoscopy, cough reflex test, swallowing provocation test. RESULTS: The essential swallowing sensations of mechanical stimulation, chemical stimulation, thermal stimulation were 84.9%, 5.4%, and 9.7%, respectively. The frequency of touching the larynx by endoscopy in the otolaryngology group and cough reflex test in dentistry was significantly higher than the other groups (p < 0.05). The correlation between the frequency and difficulty or effectiveness of the sensory tests indicated that the frequency and difficulty are significantly correlated between each item. CONCLUSION: Our results aid in increasing understanding and selection of pharyngolaryngeal sensation evaluation for dysphagia patients.
Predominant Vertical Location of Benign Vocal Fold Lesions by Sex and Music Genre: Implication for Pathogenesis International-journal Peer-reviewed

Mayu Hirosaki, Takeharu Kanazawa, Daigo Komazawa, Ujimoto Konomi, Yu Sakaguchi, Yukio Katori, Yusuke Watanabe

The Laryngoscope　131　(7)　E2284-E2291　2021/01/09
Publisher: Wiley
DOI： 10.1002/lary.29378 　

ISSN： 0023-852X

eISSN： 1531-4995

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OBJECTIVES/HYPOTHESIS: Vertical locations of vocal fold mucosal lesions (VFMLs) vary along the free edge. As the vertical contact area of vocal folds (VFs) depends on the vocal register, lesions may occur in the contact area of more frequently used vocal registers. This study investigated the cause of location variations by comparing the vertical sites of VFMLs in singers of both sexes with different music genres. STUDY DESIGN: Retrospective review. METHODS: Sixty professional classical and rock singers (11 male classical [M-classical], 22 male rock [M-rock], 13 female classical [F-classical], and 14 female rock [F-rock] singers) who underwent microlaryngeal surgery for VF polyps and nodules and their 108 lesions were enrolled. The VF free edge was vertically divided into three equal parts and classified into the following four lesion sites: upper, middle, lower, and multiple sites. RESULTS: Upper lesions were most common among F-classical singers (73.9%), whereas lower lesions were most common among M-classical (90.0%) and M-rock (60.6%) singers. Among lesions localized to a single site, lower lesions were most common among F-rock singers (37.0%). F-classical singers had significantly more upper lesions than the other groups (P < .001). M-classical singers had significantly more lower lesions than female singers of any genre (P < .001). CONCLUSION: Upper lesions were most common among F-classical singers who mostly used the head voice. Lower lesions were most common among singers who mainly used the modal voice. This study suggests that sex, the dominant vocal register used for singing, and mechanical stress on VFs influence the vertical site of VFMLs. LEVEL OF EVIDENCE: 4 Laryngoscope, 131:E2284-E2291, 2021.
Whole exome sequencing and establishment of an organoid culture of the carcinoma showing thymus-like differentiation (CASTLE) of the parotid gland Peer-reviewed

Tomohiko Ishikawa, Takenori Ogawa, Ayako Nakanome, Yasunari Yamauchi, Hajime Usubuchi, Masahiro Shiihara, Takuya Yoshida, Yasunobu Okamura, Kengo Kinoshita, Yukio Katori, Toru Furukawa

Virchows Archiv　2021/01/07

DOI： 10.1007/s00428-020-02981-8 　

ISSN： 0945-6317

eISSN： 1432-2307
COVID-19 Transmission at Schools in Japan Peer-reviewed

Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Noriko Sugawara, Kaoru Igarashi, Motoo Fujita, Shigeo Kure, Shin Takayama, Michiaki Abe, Junichi Tanaka, Akiko Kikuchi, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tadashi Ishii

The Tohoku Journal of Experimental Medicine　255　(3)　239-246　2021
Publisher: Tohoku University Medical Press
DOI： 10.1620/tjem.255.239 　

ISSN： 0040-8727

eISSN： 1349-3329

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The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a global public health concern in 2021. However, the risk of attending schools during the pandemic remains unevaluated. This study estimated the secondary transmission rate at schools using the results of a real-time reverse transcription-polymerase chain reaction (RT-PCR) screening test performed between July 2020 and April 2021, before starting the nationwide mass vaccination. A total of 1,924 students (20 RT-PCR-positive; 1.0%) from 52 schools or preschools were evaluated, together with 1,379 non-adults (95 RT-PCR-positive; 6.9%) exposed to SARS-CoV-2 in non-school environments. Assuming that the infectious index cases were asymptomatic and the transmission at schools followed a Bernoulli process, we estimated the probability of transmission after each contact at school as approximately 0.005 (0.5% per contact) with the current infection prevention measures at schools in Japan (i.e., hand hygiene, physical distancing, wearing masks, and effective ventilation). Furthermore, assuming that all children are capable of carrying the infection, then contact between an index case and 20-30 students per day at schools would yield the expected value for secondary cases of ≥ 1.0, during the 10 days of the infectious period. In conclusion, with the current infection prevention measures at schools in Japan, secondary transmission at schools would occur in approximately every 200 contacts. When considering this rate, compliance with the current infection prevention measures at schools and early detection and quarantine of the index cases would be effective in preventing the spread of COVID-19 at schools.
Preoperative Endovascular Embolization in an Easily Bleeding Respiratory Epithelial Adenomatoid Hamartoma of the Olfactory Cleft: A Case Report.

Jun Suzuki, Hiroki Tozuka, Tomotaka Hemmi, Hiroyuki Ikushima, Tomohiko Ishikawa, Yohei Morishita, Kazuhiro Nomura, Mitsuru Sugawara, Yukio Katori

The Tohoku journal of experimental medicine　254　(2)　107-110　2021

DOI： 10.1620/tjem.254.107 　

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Respiratory epithelial adenomatoid hamartomas (REAHs) are rare tumors occurring in the nasal cavity and sinuses, and their etiology is unknown. REAH is a relatively recently established lesion and is often misdiagnosed as nasal polyposis or other tumors. Preoperative endovascular embolization for sinonasal tumors is now widely accepted as an effective method to reduce blood loss, soften the tumor, and facilitate surgical procedures. However, to the best of our knowledge, there are no reports of the requirement for preoperative embolization in the management of REAH. Here, we present a 70-year-old man with an easily bleeding REAH of the olfactory cleft, vascularized by branches of the bilateral internal and external carotid arteries. We removed the tumor endoscopically after preoperative embolization of the bilateral sphenopalatine arteries. Histological investigation revealed an intratumoral hemorrhage accompanying the REAH, with no evidence of a residual or recurrent tumor during the last follow-up at 3 months. In conclusion, accurate preoperative diagnosis and proper preoperative interventions such as embolization are needed for safe and adequate treatment of REAHs that have an abundant blood flow.
Impacts of Natural Environmental Factors and Prevalence of Airway Symptoms on the Local Spread of COVID-19: A Time-Series Analysis in Regional COVID-19 Epidemics.

Tadashi Ishii, Shigeki Kushimoto, Yukio Katori, Shigeo Kure, Kaoru Igarashi, Motoo Fujita, Noriko Sugawara, Shin Takayama, Michiaki Abe, Junichi Tanaka, Akiko Kikuchi, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tetsuya Akaishi

The Tohoku journal of experimental medicine　254　(2)　89-100　2021

DOI： 10.1620/tjem.254.89 　

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Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the world's largest public health concern in 2021. This study evaluated the associations of the prevalence of airway symptoms among the tested individuals and data regarding the natural environmental factors with the weekly number of newly diagnosed COVID-19 patients in Sendai City (Nt). For the derivatives of the screening test results, data from individuals with a contact history who underwent nasopharyngeal swab reverse transcription-polymerase chain reaction (RT-PCR) testing between July 2020 and April 2021 (6,156 participants, including 550 test-positive patients) were used. The value of Nt correlated with the weekly RT-PCR test-positive rate after close contact, prevalence of cough symptoms in test-positive individuals or in test-negative individuals, lower air temperature, lower air humidity, and higher wind speed. The weekly test-positive rate correlated with lower air humidity and higher wind speed. In cross-correlation analyses, natural environmental factors correlated with the regional epidemic status on a scale of months, whereas the airway symptoms among non-COVID-19 population affected on a scale of weeks. When applying an autoregression model to the serial data of Nt, large-scale movements of people were suggested to be another factor to influence the local epidemics on a scale of days. In conclusion, the prevalence of cough symptoms in the local population, lower air humidity or higher wind speed, and large-scale movements of people in the locality would jointly influence the local epidemic status of COVID-19.
Predictors of SARS-CoV-2 Positivity Based on RT-PCR Swab Tests at a Drive-Through Outpatient Clinic for COVID-19 Screening in Japan Peer-reviewed

Tadashi Ishii, Shigeki Kushimoto, Yukio Katori, Shigeo Kure, Kaoru Igarashi, Motoo Fujita, Shin Takayama, Michiaki Abe, Junichi Tanaka, Akiko Kikuchi, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tetsuya Akaishi

The Tohoku Journal of Experimental Medicine　253　(2)　101-108　2021
Publisher: Tohoku University Medical Press
DOI： 10.1620/tjem.253.101 　

ISSN： 0040-8727

eISSN： 1349-3329
Discovery of a chemical compound that suppresses expression of BEX2, a dormant cancer stem cell-related protein International-journal Peer-reviewed

Satoshi Saijoh, Mao Nakamura-Shima, Rie Shibuya-Takahashi, Ryo Ito, Akira Sugawara, Tomoko Yamazaki, Takayuki Imai, Yukinori Asada, Kazuto Matsuura, Wataru Iwai, Yuta Wakui, Makoto Abue, Sadafumi Kawamura, Yu Katayose, Haruna Fujimori, Mai Mochizuki, Jun Yasuda, Kazunori Yamaguchi, Kazuo Sugamura, Kennichi Satoh, Yukio Katori, Keiichi Tamai

Biochemical and Biophysical Research Communications　537　132-139　2021/01
Publisher: Elsevier BV
DOI： 10.1016/j.bbrc.2020.11.022 　

ISSN： 0006-291X

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Cancer stem cells (CSCs) are believed to cause cancer metastasis and recurrence. BEX2 (brain expressed X-linked gene 2) is a CSC-related gene that is expressed in dormant CSCs in cholangiocarcinoma and induces resistance against chemotherapy. The aim of the present study was to identify small compounds that have activity to inhibit BEX2 expression and result in the attenuation of CSC-related phenotypes. We screened 9600 small chemical compounds in high-throughput screening using cholangiocarcinoma cell line HuCCT1 expressing BEX2 protein fused with NanoLuc, and identified a compound, BMPP (1, 3-Benzenediol, [4-(4-methoxyphenyl)-1H-pyrazol-3-yl]). BMPP was found to exert decreasing effects on BEX2 protein expression and G0 phase population of the tumor cells, and increasing effects on ATP levels and chemotherapeutic sensitivity of the cells. These findings indicate that BMPP is a valuable chemical compound for reducing dormant CSC-related phenotypes. Thus, the identification of BMPP as a potential CSC suppressor provides scope for the development of novel therapeutic modalities for the treatment of cancers with BEX2 overexpressing CSCs.
Objective assessment of autophony during phonation in the diagnosis of patulous Eustachian tube patients. International-journal Invited

Ryoukichi Ikeda, Shinji Hamanishi, Toshiaki Kikuchi, Hidetoshi Oshima, Yoshinobu Kawamura, Yusuke Kusano, Tetsuaki Kawase, Yukio Katori, Hiroshi Wada, Toshimitsu Kobayashi

Auris, nasus, larynx　48　(4)　738-744　2020/12/29

DOI： 10.1016/j.anl.2020.12.001 　

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OBJECTIVE: A system enabling the objective assessment of the transmission of voice sounds to the external auditory canal (EAC) during phonation has recently been revised. Our aim was to evaluate the effectiveness of this new system in the diagnosis of patulous Eustachian tube (PET) patients by comparing the results obtained using this method with those obtained from conventional objective tests to diagnose PET. METHODS: A prospective survey of medical records was included with definite PET, possible PET, and sensorineural hearing loss as control. The measurement system consists of a personal computer, an AD/DA converter (NI 6361, National Instruments), a probe microphone system for recording voice sound (ER-10C, Etymotic Research) and two microphones for measuring noise sound in the EAC (ER-10B+, Etymotic Research). Pronouncing the "Ni" sound for 5 s were recorded with these three microphones. The ratio of the maximum sound pressure of voice sound and noise sound in EAC (EAC/Voice) was simultaneously calculated, and results were displayed on a personal computer for diagnosing. RESULTS: Thirty-one patients of 42 ears with definite PET, 26 patients of 38 ears with possible PET, and 12 patients of 24 ears with sensorineural hearing loss as control were included. The EAC/Voice were 8.63 ± 5.43, 25.41 ± 32.63, and 25.87 ± 24.93 in the control, definite PET, and possible PET group respectively. The control group was significantly different from the definite PET (p < 0.05) and possible PET group (p < 0.05). ROC curve analysis confirmed 14.7 as the best diagnostic cut-off value of EAC/Voice (area under the curve=0.782, 95% CI 0.671-0.894). By adopting this cut-off point, 25 (56.8%) and 22 (61.1%) ears were determined as positive findings in the definite PET and possible PET group, respectively. There was no significant correlation between the positive findings judged by the current method and that of sonotubometry in the control (r = -0.63, p = 0.769), definite PET (r = 0.12, p = 0.451), and possible PET group (r = 0.12, p = 0.451). CONCLUSION: The current system is more useful in the objective assessment of autophony during phonation by calculating the ratio of voice sound and elicited noise sound transmitted in the EAC (EAC/Voice). This method seems promising because it is able to detect cases eluding conventionally used test methods such as sonotubometry performed without phonation, thereby increasing the accuracy of PET diagnoses.
Middle ear adenoma with facial palsy: A case report and a review of the literature: Middle ear adenoma with facial palsy. International-journal Invited

Tadahisa Shishido, Ryoukichi Ikeda, Jun Suzuki, Yohei Honkura, Yasutoshi Koshiba, Gosuke Watarai, Tomonori Kanbayashi, Masaki Hatano, Daisuke Yamauchi, Tetsuaki Kawase, Yukio Katori

Auris, nasus, larynx　49　(3)　529-533　2020/11/24

DOI： 10.1016/j.anl.2020.11.003 　

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A 52-year-old man presented to our emergency department with an acute onset of right-sided facial nerve (FN) palsy of House-Brackmann grade V. Electroneurography (ENoG) was conducted with no response at the right FN, as compared with the left FN (0%). We performed a biopsy of the right middle ear mass and histological studies showed the tumor to be neuroendocrine tumors (NET) of the middle ear. We resected the tumor with canal wall down mastoidectomy and reconstructed the posterior meatal wall with soft tissue. Three months after surgery, the FN paralysis had improved with House-Brackmann grade II. We reviewed cases of NET with FN palsy, and nine patients, including our case, have been reported. Our case is the first report of ENoG for the description of FN palsy due to NET. Although the ENoG value was 0%, it was remarkably improved by surgery. The other cases of NET patients with FN palsy also recovered FN function after surgery. These results suggest that it is recommended to perform the total resection of the tumor to improve the FN function.
N100m latency shortening caused by selective attention. International-journal Peer-reviewed

Yuri Nomura, Tetsuaki Kawase, Akitake Kanno, Nobukazu Nakasato, Ryuta Kawashima, Yukio Katori

Brain research　1751　147177-147177　2020/10/26

DOI： 10.1016/j.brainres.2020.147177 　

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The N100m response to a specific same-sound stimulus may be altered by the degree of attention paid to the stimulus. When participants selectively pay attention to the stimulus, the N100m amplitude increases; however, minimal effects are observed on the N100m latency. In this study, we examined the effects of selective special attention (motivation) to extract the frequency (or pitch) information from a probe tone on the N100m response to the probe tone. We compared the N100m latencies and amplitudes using magnetoencephalography, with the following three experimental conditions: 1) vocalization task protocol (vocalize in tune with the pitch of the probe tone after the presentation of the probe tone), 2) hearing task protocol (just listen to the probe tone), and 3) imagining (just imagine the vocalization in tune with the probe tone). The results indicated that the N100m latency in response to the probe tone was significantly shortened in the vocalization and imagining tasks compared with the hearing task in the right hemisphere of the brain. The amplitude was significantly increased in the vocalization task compared with the imagining and hearing tasks in the right hemisphere, and in the vocalization task compared with the hearing task in the left hemisphere of the brain; that is, the attention and/or motivation required to extract the information from the stimulus tones may have caused N100m latency shortening. To our knowledge, this study is the first to demonstrate that the N100m latency may be shortened under particular attentional conditions in response to a simple tone.
Mitochondrial dysfunction in GnRH neurons impaired GnRH production. International-journal Peer-reviewed

Yoshiteru Kagawa, Banlanjo Abdulaziz Umaru, Subrata Kumar Shil, Ken Hayasaka, Ryo Zama, Yuta Kobayashi, Hirofumi Miyazaki, Shuhei Kobayashi, Chitose Suzuki, Yukio Katori, Takaaki Abe, Yuji Owada

Biochemical and biophysical research communications　530　(1)　329-335　2020/09/10

DOI： 10.1016/j.bbrc.2020.07.090 　

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The onset establishment and maintenance of gonadotropin-releasing hormone (GnRH) secretion is an important phenomenon regulating pubertal development and reproduction. GnRH neurons as well as other neurons in the hypothalamus have high-energy demands and require a constant energy supply from their mitochondria machinery to maintain active functioning. However, the involvement of mitochondrial function in GnRH neurons is still unclear. In this study, we examined the role of NADH Dehydrogenase (Ubiquinone) Fe-S protein 4 (Ndufs4), a member of the mitochondrial complex 1, on GnRH neurons using Ndufs4-KO mice and Ndufs4-KO GT1-7 cells. Ndufs4 was highly expressed in GnRH neurons in the medial preoptic area (MPOA) and NPY/AgRP and POMC neurons in the arcuate (ARC) nucleus in WT mice. Conversely, there was a significant decrease in GnRH expression in MPOA and median eminence of Ndufs4-KO mice, followed by impaired peripheral endocrine system. In Ndufs4-KO GT1-7 cells, Gnrh1 expression was significantly decreased with or without stimulation with either kisspeptin or NGF, whereas, stimulation significantly increased Gnrh1 expression in control cells. In contrast, there was no difference in cell signaling activity including ERK and CREB as well as the expression of GPR54, TrkA and p75NTR, suggesting that Ndufs4 is involved in the transcriptional regulation system for GnRH production. These findings may be useful in understanding the mitochondrial function in GnRH neuron.
Systematic Review of Surgical Outcomes Following Repair of Patulous Eustachian Tube. International-journal Peer-reviewed

Ryoukichi Ikeda, Hiroshi Hidaka, Toshiaki Kikuchi, Nobuo Ohta, Tetsuaki Kawase, Yukio Katori, Toshimitsu Kobayashi

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology　41　(8)　1012-1020　2020/09

DOI： 10.1097/MAO.0000000000002753 　

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OBJECTIVE: To perform a systematic review and meta-analysis of surgical outcomes following repair of patulous Eustachian tube (PET). DATA SOURCES: Analysis of cases collected from studies published between January 1990 and December 2018 and identified using PubMed, Google Scholar, and Cochrane databases. STUDY SELECTION: Articles addressing interventions to treat PET were selected. DATA EXTRACTION: The database was searched using the keywords "patulous Eustachian tube treatment" and yielded 1,370 studies. Twenty studies were eligible for inclusion. DATA SYNTHESIS: A total of 914 cases were evaluated for surgical approach, patient outcomes, and complications. The reported techniques were categorized by the procedure type, including ventilation tube insertion, mass loading of the tympanic membrane, ET injection, plug surgery, shim surgery, tuboplasty, and ET closure. Overall PET symptom improvement were reported for ventilation tube insertion (79 cases, mean: 58%, 95% CI: 47-69%), mass loading of the tympanic membrane (43 cases, mean: 50%, 95% CI: 32-69%), ET injection (139 cases, mean: 47%, 95% CI: 38-56%), plug surgery (386 cases, mean: 81%, 95% CI: 77-85%), shim surgery (122 cases, mean: 62%, 95% CI: 53-70%), tuboplasty (105 cases, mean: 41%, 95% CI: 31-51%), and ET closure (40 cases, mean: 66%, 95% CI: 49-80%). A low incidence of minor complications was reported. CONCLUSIONS: This systematic review describes clinical outcome data following surgical management of PET. Plug surgery and shim surgery show relatively high effectiveness and safety. Further prospective studies that compare surgical approaches for PET are needed.
Management of adenoid cystic carcinoma of the head and neck: a single-institute study with over 25-year follow-up. International-journal Peer-reviewed

Eiichi Ishida, Takenori Ogawa, Masahiro Rokugo, Tomohiko Ishikawa, Shun Wakamori, Akira Ohkoshi, Hajime Usubuchi, Kenjiro Higashi, Ryo Ishii, Ayako Nakanome, Yukio Katori

Head & face medicine　16　(1)　14-14　2020/07/02
Publisher: Springer Science and Business Media LLC
DOI： 10.1186/s13005-020-00226-2 　

eISSN： 1746-160X

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BACKGROUND: Adenoid cystic carcinoma is a rare malignant tumor arising from exocrine glands such as the major and minor salivary glands of the paranasal sinuses or the external auditory canal. Although multiple retrospective clinical studies of ACC have been reported to date, clinical questions, such as 1) long-term prognosis beyond 20 years, 2) usefulness and suitability for treatment of therapeutic interventions, 3) therapeutic goal to aim for, and 4) prognosis by recurrence sites, are still unclear. METHODS: To improve understanding and management of adenoid cystic carcinoma of the head and neck (ACC), a retrospective study with 58 new ACC cases between 1991 and 2016 was performed. The median observation period was 66.8 months (range 3-316 months). The overall clinical stages were as follows: I, 6.9%; II, 25.9%; III, 19.0%; and IV, 48.2%. Histology was cribriform/tubular type (C-T type) in 62.0% and solid type in 27.5%. The main treatment strategy was definitive surgery, which was performed in 75.2% of cases. RESULTS: Overall 10-year, 20-year, and 25-year survivals were 63.7, 27.3, and 20.0%, respectively. Similarly, disease-specific survival (DSSs) was 65.7, 51.2, and 38.4%, respectively, and disease-free survival was 25.2, 9.4, and 9.4%, respectively. Conducting surgery (HR: 0.19, 95% CI: 0.06-0.61, p = 0.005) and C-T type (HR: 0.32, 95% CI: 0.11-0.93, p = 0.036) were independent prognostic predictors of DSS. DSS was significantly prolonged after salvage surgery for both locoregional recurrence (p = 0.004) and lung metastatic recurrence (p = 0.012, vs best supportive care). CONCLUSIONS: In ACC cases, both initial surgical treatment and repetitive surgical resection of resectable recurrent lesions, including both locoregional and lung metastases, resulted in longer survival. The major goal of treatment for ACC may be long-term survival including cancer-bearing survival, resulting in either natural death or intercurrent-disease death, since judging cure of ACC is almost impossible. TRIAL REGISTRATION: Retrospectively registered.
The incudopetrosal joint of the human middle ear: a transient morphology in fetuses

José Francisco Rodríguez‐Vázquez, Masahito Yamamoto, Ji Hyun Kim, Zhe‐Wu Jin, Yukio Katori, Gen Murakami

Journal of Anatomy　237　(1)　176-187　2020/07
Publisher: Wiley
DOI： 10.1111/joa.13181 　

ISSN： 0021-8782

eISSN： 1469-7580
Pulsatile tinnitus caused by pneumocephalus after Janneta surgery. International-journal Peer-reviewed

Ryoukichi Ikeda, Toshiaki Kikuchi, Shunsuke Sato, Hidetoshi Oshima, Yoshinobu Kawamura, Yusuke Kusano, Tetsuaki Kawase, Yukio Katori, Toshimitsu Kobayashi

Auris, nasus, larynx　48　(4)　793-796　2020/06/22

DOI： 10.1016/j.anl.2020.05.024 　

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Pulsatile tinnitus of nonvascular origin is rare. We herein present a case of pulsatile tinnitus complicated with Jannetta surgery due to a communication created between the drilled mastoid cells and epidural space. She was successfully cured by otological surgery where the mastoid tip was packed with bone cement. A 68-year-old woman was referred to the previous hospital with complaints of right autophony, aural fullness, hyperacusis to her footsteps, and pulsatile tinnitus for the past three years. She had received Jannetta surgery for right hemifacial spasm seven years before. The computed tomography (CT) of the right temporal bone showed bony dehiscence between the mastoid cells and posterior cranial fossa. She underwent otological surgery to obliterate the tip of the mastoid cavity with artificial bone cement (BIOPEXⓇ) under general anesthesia. Her annoying aural symptoms were immediately abolished and she has been free from symptoms at ten months after surgery. It is critical to ensure the closure of any communication created between the middle ear and epidural space during surgeries in order to prevent the occurrence of pulsatile tinnitus.
Magnetic foreign bodies in the hypopharynx: Usefulness of video laryngoscopy. International-journal Peer-reviewed

Jun Suzuki, Shotaro Koizumi, Takuya Endo, Tomotaka Hemmi, Yukio Katori

Pediatrics international : official journal of the Japan Pediatric Society　62　(6)　748-749　2020/06/03
Publisher: Wiley
DOI： 10.1111/ped.14174 　

ISSN： 1328-8067

eISSN： 1442-200X
Location of the stapedius muscle with reference to the facial nerve in patients with unilateral congenital aural atresia: implication for active middle ear implants surgery International-journal Peer-reviewed

Ryoukichi Ikeda, Hiroshi Hidaka, Takaki Murata, Tetsuaki Kawase, Yukio Katori, Toshimitsu Kobayashi

Acta Oto-Laryngologica　140　(6)　445-449　2020/06/02
Publisher: Informa UK Limited
DOI： 10.1080/00016489.2020.1725113 　

ISSN： 0001-6489

eISSN： 1651-2251

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Background: Detailed investigations of the stapedial muscle (SM) in congenital aural atresia (CAA) patients have yet to be adequately conducted.Objectives: To assess image variations in the mastoid segment of the facial nerve (FN) and SM in CAA.Materials and methods: A total of nine patients comprising of 9 ears with unilateral CAA were studied. The courses of the FN and SM were evaluated from the basic point to 1 mm intervals between the mastoid portion of FN, and measured from the mean X and Y values in each group.Results: The atresia side of FN among the Y values showed significant differences compared to the contralateral side. In terms of the SM, there were no significant differences in both the X and Y values. The stapedial muscle of the CAA patients was located medially to the FN. Conversely, the distance from the PSC to the FN revealed no significant differences with regard to the X and Y values for each group.Conclusion: The current observations revealed that the SM is located more posterior to the FN in CAA patients, and this is mainly attributed to the laterally and anteriorly displaced FN.
Sialodochitis fibrinosa: salivary duct obstruction by eosinophil extracellular traps? International-journal Peer-reviewed

Yoshinobu Kawamura, Ryoukichi Ikeda, Toru Hori, Takatsuna Sasaki, Yui Miyabe, Mineyo Fukuchi, Kazuhiro Sakamoto, Nobuo Ohta, Tetsuaki Kawase, Yukio Katori, Shigeharu Ueki

Oral diseases　26　(7)　1459-1463　2020/05/20

DOI： 10.1111/odi.13434 　

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Sialodochitis fibrinosa (also known as Kussmaul disease) was originally described by Kussmaul in 1879. This condition involves recurrent parotid grand swelling and mucus plugs containing leukocytes and Charcot-Leyden crystals (CLCs) (Ray et al., 2015) (Baer et al., 2017) (Flores et al., 2016). Sialodochitis fibrinosa also includes recurrent salivary gland swelling with fibrinous eosinophil-rich mucus plugs. Although the disease is relatively rare, a recent review of Japanese and English literature revealed 59 previous cases (Baer et al., 2017). The authors of that review emphasised the major role of eosinophilic inflammation in sialodochitis fibrinosa and recommended redefinition of the disease as 'eosinophilic sialodochitis'.
First Two Cases of Infected Aortic Aneurysm Caused by Non-Vaccine Streptococcus pneumoniae Serotype 23A. International-journal Peer-reviewed

Risako Kakuta, Ryuichi Nakano, Hisakazu Yano, Daiki Ozawa, Nobuo Ohta, Takayuki Matsuoka, Naotaka Motoyoshi, Shunsuke Kawamoto, Yoshikatsu Saiki, Yukio Katori, Mitsuo Kaku

Annals of laboratory medicine　40　(3)　270-273　2020/05

DOI： 10.3343/alm.2020.40.3.270 　

ISSN： 2234-3806
Risk factors of post-tonsillectomy dysgeusia Peer-reviewed

Shiori Kitaya, Toshiaki Kikuchi, Izumi Yahata, Ryoukichi Ikeda, Kazuhiro Nomura, Tetsuaki Kawase, Yukio Katori

Auris Nasus Larynx　47　(2)　238-241　2020/04

DOI： 10.1016/j.anl.2019.07.005 　

ISSN： 0385-8146

eISSN： 1879-1476
Establishment of a Monoclonal Antibody That Recognizes Cysteine-Rich Domain 1 of Human CD271. International-journal Peer-reviewed

Shinkichi Morita, Mai Mochizuki, Rie Shibuya-Takahashi, Mao Nakamura-Shima, Tomoko Yamazaki, Takayuki Imai, Yukinori Asada, Kazuto Matsuura, Sadafumi Kawamura, Kazunori Yamaguchi, Jun Yasuda, Kazuo Sugamura, Yukio Katori, Kennichi Satoh, Keiichi Tamai

Monoclonal antibodies in immunodiagnosis and immunotherapy　39　(1)　6-11　2020/02

DOI： 10.1089/mab.2019.0040 　

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CD271 is a common receptor for all neurotrophins that is localized to neurons, endothelial cells, and the basal layer of the epithelium in normal tissue. Recently, we and others reported that CD271 plays essential roles in the development of squamous cell carcinoma, especially in tumor-initiating cells. Since little is known about how CD271 regulates cancer cell initiation and proliferation, antibodies that recognize different domains of CD271 are needed to enable investigation. Therefore, this study aimed to develop an antihuman CD271 antibody by immunizing mice with a CD271 antigen produced by a baculovirus. The antibody was named hCD271mAb#13, and it recognized cysteine-rich domain 1 with a higher affinity than the commercially available antibody ME20.4. We determined that hCD271mAb#13 is suitable for flow cytometry, Western blotting, immunocytochemistry, and immunohistochemistry of formalin-fixed paraffin-embedded tissue. Use of hCD271mAb#13 for CD271 labeling could enable detailed analyses of cancer cell regulation and other biological processes.
Improvement of a delayed swallowing reflex following treatment for advanced head and neck cancer. International-journal Peer-reviewed

Akira Ohkoshi, Kengo Kato, Takenori Ogawa, Ayako Nakanome, Ryo Ishii, Yukio Katori

Cancers of the head & neck　5　8-8　2020

DOI： 10.1186/s41199-020-00055-5 　

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Background: The latency of the swallowing reflex is an important factor causing dysphagia in head and neck cancer patients. Although there are many reports comparing voluntary swallowing function before and after treatment, few studies have focused on the latency of the swallowing reflex, which is a risk factor for pneumonia due to silent aspiration. The aim of this retrospective study was to clarify the changes in the latency of the swallowing reflex before and after treatment. Methods: The latency of the swallowing reflex was quantified using the time from the injection of 1 ml of distilled water into the pharynx through a nasal catheter to the onset of swallowing. Results: The latency time of the swallowing reflex was significantly decreased 3 months after treatment compared to before treatment. A significant reduction was also observed in patients with pharyngeal cancer who underwent chemoradiation therapy. Conclusions: This retrospective study showed that a delayed swallowing reflex improved with treatment in advanced head and neck cancer patients. Trial registration: The Institutional Review Board of Tohoku University Hospital (Number 2014-1-274).
A Case of an Incidentally Removed Lingual Osseous Choristoma. International-journal Peer-reviewed

Tomotaka Hemmi, Jun Suzuki, Satoko Sato, Masumi Tabata, Kojiro Watanabe, Mitsuru Sugawara, Yukio Katori

Case reports in otolaryngology　2020　3498915-3498915　2020

DOI： 10.1155/2020/3498915 　

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Lingual osseous choristoma is a rare benign tumor consisting of normal matured bone tissue. It was first reported in 1913, and less than 100 cases of lingual osseous choristomas, mainly in their twenties and thirties, have been reported in the English literature until now. Here, we report an additional case of lingual osseous choristoma, in an elderly patient, that was incidentally removed by coughing and cured without additional interventions. An 89-year-old male patient was referred to our department for an evaluation of chronic cough. When we examined his oral cavity and pharynx, he expectorated a 10 -mm mass which was histologically diagnosed as an osseous choristoma. We confirmed the well-defined, rounded, high-density mass with a tiny pedicle on the base of the tongue in previous cervical spine CT images. No signs of recurrence were found during the 15-month follow-up examination. Our case serves as a reminder of this rare entity in the diagnosis of tongue masses of the elderly.
Abdominal Aortic Graft Infection Caused by stG485.0, ST29 Streptococcus dysgalactiae subsp. equisimilis Peer-reviewed

Risako Kakuta, Takuya Shimizu, Hitoshi Goto, Shiro Endo, Hajime Kanamori, Nobuo Ohta, Ryuichi Nakano, Hisakazu Yano, Yukio Katori, Mitsuo Kaku

Japanese Journal of Infectious Diseases　73　(1)　65-67　2020
Publisher: Editorial Committee of Japanese Journal of Infectious Diseases, National Institute of Infectious Dis
DOI： 10.7883/yoken.jjid.2019.171 　

ISSN： 1344-6304

eISSN： 1884-2836
A computational fluid dynamics simulation of liquid swallowing by impaired pharyngeal motion: bolus pathway and pharyngeal residue. International-journal Peer-reviewed

Ohta J, Ishida S, Kawase T, Katori Y, Imai Y

American journal of physiology. Gastrointestinal and liver physiology　317　(6)　G784-G792　2019/12

DOI： 10.1152/ajpgi.00082.2019 　

ISSN： 0193-1857

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Common practices to improve the ability to swallow include modifying physical properties of foods and changing the posture of patients. Here, we quantified the effects of the viscosity of a liquid bolus and patient posture on the bolus pathway and pharyngeal residue using a computational fluid dynamics simulation. We developed a computational model of an impaired pharyngeal motion with a low pharyngeal pressure and no pharyngeal adaptation. We varied viscosities from 0.002 to 1 Pa·s and postures from -15° to 30° (from nearly vertical to forward leaning). In the absence of pharyngeal adaptation, a honey-like liquid bolus caused pharyngeal residue, particularly in the case of forward-leaning postures. Although the bolus speed was different among viscosities, the final pathway was only slightly different. The shape, location, and tilting of the epiglottis effectively invited a bolus to two lateral pathways, suggesting a high robustness of the swallowing process.NEW & NOTEWORTHY Thickening agents are often used for patients with dysphagia. An increase in bolus viscosity not only reduces the risk of aspiration but also can cause a residual volume in the pharynx. Because information obtained from videofluoroscopic swallowing studies is only two-dimensional, measurement of pharyngeal residue is experimentally difficult. We successfully quantified the three-dimensional bolus pathway and the pharyngeal residual volume using computational modeling and simulation.
In-home auditory training using audiovisual stimuli on a tablet computer: Feasibility and preliminary results Peer-reviewed

Takeshi Sato, Tomoko Yabushita, Shuichi Sakamoto, Yukio Katori, Tetsuaki Kawase

Auris Nasus Larynx　47　(3)　348-352　2019/11
Publisher: Elsevier BV
DOI： 10.1016/j.anl.2019.09.006 　

ISSN： 0385-8146
Plug size selection protocol for the treatment of intractable patulous Eustachian tube with Kobayashi Plug Peer-reviewed

Ryoukichi Ikeda, Toshiaki Kikuchi, Yoshinobu Kawamura, Hiromitsu Miyaaki, Tetsuaki Kawase, Yukio Katori, Toshimitsu Kobayashi

Acta Oto-Laryngologica　139　(10)　849-853　2019/10/03

DOI： 10.1080/00016489.2019.1651939 　

ISSN： 0001-6489

eISSN： 1651-2251
Parotid secretory carcinoma with high-grade transformation. Peer-reviewed

Numano Y, Ogawa T, Ishikawa T, Usubuchi H, Nakanome A, Ohkoshi A, Ishida E, Rokugo M, Katori Y

Auris, nasus, larynx　47　(6)　1043-1048　2019/10

DOI： 10.1016/j.anl.2019.10.003 　

ISSN： 0385-8146

eISSN： 1879-1476
Surgical treatments for a case of superior canal dehiscence syndrome associated with patulous Eustachian tube Peer-reviewed

Ryoukichi Ikeda, Hiromitsu Miyazaki, Masahiro Morita, Daisuke Yamauchi, Tetsuaki Kawase, Yukio Katori, Toshimitsu Kobayashi

Auris Nasus Larynx　46　(4)　630-635　2019/08
Publisher: Elsevier BV
DOI： 10.1016/j.anl.2018.09.008 　

ISSN： 0385-8146
Vibrant Soundbridge implantation via a retrofacial approach in a patient with congenital aural atresia Peer-reviewed

Ryoukichi Ikeda, Hiroshi Hidaka, Takaki Murata, Hiromitsu Miyazaki, Yukio Katori, Toshimitsu Kobayashi

Auris Nasus Larynx　46　(2)　204-209　2019/04

DOI： 10.1016/j.anl.2018.08.012 　

ISSN： 0385-8146

eISSN： 1879-1476
Complications of using Gore-Tex in medialization laryngoplasty: case series and literature review. International-journal Peer-reviewed

Kenichi Watanabe, Ai Hirano, Yohei Honkura, Kazutaka Kashima, Masayuki Shirakura, Yukio Katori

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery　276　(1)　255-261　2019/01

DOI： 10.1007/s00405-018-5204-0 　

ISSN： 0937-4477

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PURPOSE: This study was performed to evaluate the incidence and contributing factors of complications associated with medialization laryngoplasty using Gore-Tex in patients with unilateral vocal fold paralysis. METHODS: A retrospective chart review was conducted for all patients who underwent medialization laryngoplasty using Gore-Tex at Tohoku University Hospital between January 2014 and April 2018. A search of series and case reports in PubMed was performed to determine the incidence of complications following medialization laryngoplasty using Gore-Tex. RESULTS: Sixty-eight patient charts were reviewed. Two patients (2.9%) had complications (infection and extrusion into the airway) related to the Gore-Tex implant after surgery. In the 555 medialization laryngoplasty cases reported in both our current data and eight additional articles, there were 11 complications related to the Gore-Tex implant (2.0%). The most common event was extrusion into the lumen, which occurred in six cases (1.1%), followed by persistent inflammation with the granulation formation (0.5%). There were 12 cases of Gore-Tex extrusion (one male, six female, and five of unknown gender). The interval to onset ranged from 1 month to 10 years (median, 49 months). CONCLUSIONS: Our findings serve as a reminder that complications can occur with Gore-Tex implants following medialization laryngoplasty in patients with unilateral vocal fold paralysis, even in the long-term. We suggest that the use of excessively large implants in women and occurrence of postoperative hematoma followed by infection are factors that may cause complications. Nevertheless, Gore-Tex has been proven to be a relatively safe and reliable material for medialization laryngoplasty.
The characteristic of patulous eustachian tube patients diagnosed by the JOS diagnostic criteria. International-journal Peer-reviewed

Yoshinobu Kawamura, Ryoukichi Ikeda, Toshiaki Kikuchi, Hiromitsu Miyazaki, Tetsuaki Kawase, Yukio Katori, Toshimitsu Kobayashi

PloS one　14　(12)　e0226908　2019

DOI： 10.1371/journal.pone.0226908 　

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OBJECTIVE: The objective is to describe characteristics of patients diagnosed with patulous Eustachian tube (PET) using the Diagnostic Criteria proposed by Japan Otological Society, and to evaluate the efficiency of objective tests to determine patent Eustachian tube. STUDY DESIGN: Retrospective. SETTING: Tertiary referral center. SUBJECTS: A retrospective survey of medical records in Sen-En Rifu Hospital identified 78 ears of 56 patients with "Definite PET" diagnosed by the JOS Diagnostic Criteria between January 2017 and December 2017. METHOD: Initial diagnosis, aural symptoms (voice autophony, aural fullness and breathing autophony), tubal obstruction procedures (posture change and pharyngeal orifice obstruction) and objective findings (tympanic membrane movement, Tubo-Tympano-Aerodynamic Graphy (TTAG) and sonotubometry) were evaluated. In addition, sonotubometry with postural change (Ohta's method), sitting CT and a newly devised PHI-10 score were also examined. RESULTS: Voice autophony, aural fullness, and breathing autophony were observed in 93.6%, 87.2%, 78.2%, respectively. In 91% of the ears, PET symptoms improved by postural change from sitting to the lying / forward-bending position. Synchronous movement of the TM upon respiration was observed in 69.1% of the ears. Positive findings of TTAG were observed in 75.6% of ears. Positive findings of sonotubometry were found in 55.1% of ears. Sonotubometry with postural change (Ohta's method), when the cut-off value of over 10dB was used, was positive in 45.2% of ears. Newly devised PHI-10 score representing severity of subjective symptoms classifying patients into no handicap, mild handicap, moderate handicap and severe handicap were observed in 12.2%, 10.8%, 18.9% and 58.1% of ears, respectively. The evaluation of the extent of patency of the ET by sitting CT indicated completely open, closed-short, and closed-long, in 68.6%, 11.4% and 21.4% of ears, respectively. Compared to the closed group, the completely open group had a significantly higher frequency of positive breathing autophony, positive sonotubometry, and positive Ohta's method. CONCLUSION: The characteristics of main symptoms and the efficiency of various tests in PET diagnosis were analyzed based on data obtained from "Definite PET" patients diagnosed by the JOS Diagnostic Criteria. The greater the availability of tests to evaluate PET, the greater the opportunities to diagnose "Definite PET". In particular, tests measuring pressure transmission between the nasopharynx and middle ear, such as TM observation and TTAG, are more sensitive than sonotubometry measuring sound transmission.
Incidence of Functional Nasal Voice in Patients With Patulous Eustachian Tube. International-journal Peer-reviewed

Yoko Suzuki, Ryoukichi Ikeda, Hiroshi Hidaka, Hiromitsu Miyazaki, Yohei Honkura, Takeshi Sato, Tetsuaki Kawase, Yukio Katori, Toshimitsu Kobayashi

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology　39　(10)　e1034-e1038-e1038　2018/12

DOI： 10.1097/MAO.0000000000001981 　

ISSN： 1531-7129

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OBJECTIVE: Some patients with a patulous Eustachian tube (PET) complain of a nasal voice. This feature is often dismissed without further investigation. As such, there are only a few reports on this important symptom and scant studies have been conducted on a sufficiently large number of cases with PET. Therefore, this study was undertaken to investigate the characteristics of patients having a nasal voice and to examine whether this symptom can be an indication of the severity of PET. STUDY DESIGN: Retrospective. SETTING: Tertiary referral center. SUBJECTS AND METHODS: A retrospective survey of medical records in Sen-En Rifu Hospital identified 85 patients (40 men and 45 women) with PET between 2013 and 2016. Diagnosis of definite PET was based on the Proposal on Diagnostic Criteria of PET announced by the Otological Society of Japan (2017). The questionnaire inquired about the presence of a nasal voice and it was distributed to each patient at the first visit to the clinic. If a patient marked "yes" for the presence of nasal voice, he/she was later asked on the telephone to exclude nasal voice ascribable to causes other than PET, such as nasal diseases. Correlation between nasal voice and patient characteristics (age, sex, affected side, and PET symptoms such as autophony of own voice, aural fullness, and autophony of breathing sounds), subjective severity of PET evaluated by patulous Eustachian tube handicap inventory-10 (PHI-10), and that with the objective severity of PET evaluated by tubo-tympano-aerodynamic-graphy (TTAG) and sonotubometry were investigated. RESULTS: Seventy-six patients (36 men and 40 women) with definite PET were evaluated in this study. Thirteen patients (17.1%) (five men and eight women) reported a nasal voice coinciding with the occurrence of PET symptoms such as voice autophony, aural fullness, and breathing autophony. Age, sex, affected side, PET symptoms (autophony of their own voice, aural fullness, and autophony of their breathing sounds), and objective findings (TTAG and sonotubometry) were not significantly different between the two groups. The average total score of the PHI-10 in the "PET associated Nasal Voice Group" was 35.8 ± 4.5, which was statistically higher than that of the "non PET associated Nasal Voice Group" 23.6 ± 10.7 (p = 0.002). Out of 76 patients, 44 were treated surgically (Kobayashi Plug). In the "PET associated Nasal Voice Group," 85% (11 out of 13) were subjected to surgical treatment, whereas 52% (33 out of 63) underwent surgical treatment in the "non PET associated Nasal Voice Group." The rate of surgical treatment was significantly higher in "PET associated Nasal Voice Group" (p = 0.047). CONCLUSION: Nasal voice due to PET symptoms was observed in 17.1% of PET patients. It was generally found in patients with severe subjective symptoms. Nasal voice can be an indication of subjective severity. However, this study failed to show objective evidence of wider Eustachian tube in such cases. Patients with a nasal voice tended to seek vigorous treatment including surgery.
Hearing recovery from deafness caused by bromate intoxication

J. Suzuki, Y. Takanashi, A. Koyama, Y. Katori

Journal of Laryngology and Otology　132　1039-1041　2018/11/01

DOI： 10.1017/S0022215118002001 　

ISSN： 0022-2151
Myeloid Sarcoma of the Paranasal Sinuses in a Patient with Acute Myeloid Leukemia. Peer-reviewed

Suzuki J, Harazaki Y, Morita S, Kaga Y, Nomura K, Sugawara M, Katori Y

The Tohoku journal of experimental medicine　246　(2)　141-146　2018/10

DOI： 10.1620/tjem.246.141 　

ISSN： 0040-8727
Lacrimal sac exposure and a superior lateral anterior pedicle flap to improve outcomes of Draf type II and III procedures International-journal Peer-reviewed

Kazuhiro Omura, Kazuhiro Nomura, Satoshi Aoki, Yukio Katori, Yasuhiro Tanaka, Nobuyoshi Otori

International Forum of Allergy & Rhinology　8　(8)　955-958　2018/08
Publisher: Wiley
DOI： 10.1002/alr.22122 　

ISSN： 2042-6976

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BACKGROUND: Although the efficacy of Draf type II and III procedures for frontal sinus diseases is well recognized, a certain amount of postoperative stenosis of the frontal neo-ostium occurs. Exposed bone induces inflammation and leads to osteoneogenesis. To prevent stenosis, we developed a surgical technique designed to minimize bone exposure while maximizing the frontal neo-ostium area created with Draf type II and III procedures. We fully exposed the lacrimal sac and used a superior lateral anterior pedicle flap to cover the exposed bone during the Draf procedure. We aimed to describe our technique. METHODS: We reviewed 19 patients who underwent a Draf type II or III procedure with our technique. Endoscopic views from the follow-ups and complications were evaluated. RESULTS: Overall, the neo-ostium remained patent in all patients. No complications, such as synechiae or orbital injury, were seen in any of the patients. CONCLUSION: Draf type II and III procedures with lacrimal sac exposure and a superior lateral anterior pedicle flap are convenient and seem to be effective. However, further studies with larger numbers of patients are needed to verify our technique.
Poor oral intake causes enteral nutrition dependency after concomitant chemoradiotherapy for pharyngeal cancers Peer-reviewed

Ryo Ishii, Kengo Kato, Takenori Ogawa, Takeshi Sato, Ayako Nakanome, Akira Ohkoshi, Ai Kawamoto-Hirano, Masayuki Shirakura, Hiroshi Hidaka, Yukio Katori

European Archives of Oto-Rhino-Laryngology　275　(6)　1607-1611　2018/06/01
Publisher: Springer Verlag
DOI： 10.1007/s00405-018-4963-y 　

ISSN： 1434-4726 0937-4477

eISSN： 1434-4726
Clinical utility of dynamic-enhanced MRI in salivary gland tumors: retrospective study and literature review Peer-reviewed

Takenori Ogawa, Ikuho Kojima, Ryo Ishii, Maya Sakamoto, Takaki Murata, Takahiro Suzuki, Kengo Kato, Ayako Nakanome, Akira Ohkoshi, Eiichi Ishida, Seiji Kakehata, Kiyoto Shiga, Yukio Katori

European Archives of Oto-Rhino-Laryngology　275　(6)　1613-1621　2018/06/01

DOI： 10.1007/s00405-018-4965-9 　

ISSN： 0937-4477

eISSN： 1434-4726
Endoscopic Modified Medial Maxillectomy for Fungal Ball of the Hypoplastic Maxillary Sinus With Bony Hypertrophy. Peer-reviewed

Nomura K, Ikushima H, Ozawa D, Shimizu Y, Arakawa K, Suzuki J, Hidaka H, Katori Y, Ohyama K

The Journal of craniofacial surgery　29　(3)　e304-e307　2018/05

DOI： 10.1097/SCS.0000000000004379 　

ISSN： 1049-2275
Parapharyngeal neuroglial heterotopia appearing as high uptake on 18F–FDG PET: case report and literature review of radiographical findings Peer-reviewed

Masayuki Kameyama, Tomohiro Kawaguchi, Hidetaka Niizuma, Takenori Ogawa, Kenichi Watanabe, Toshiaki Hayashi, Kanako Sato, Masayuki Kanamori, Mika Watanabe, Yukio Katori, Shigeo Kure, Teiji Tominaga

Acta Neurochirurgica　160　(4)　801-809　2018/04/01
Publisher: Springer-Verlag Wien
DOI： 10.1007/s00701-017-3403-x 　

ISSN： 0942-0940 0001-6268

eISSN： 0942-0940
Duplicated internal auditory canal with inner ear malformation: Case report and literature review Peer-reviewed

Yoshitaka Takanashi, Tetsuaki Kawase, Yasuko Tatewaki, Jun Suzuki, Izumi Yahata, Yuuri Nomura, Kazuha Oda, Hiromitsu Miyazaki, Yukio Katori

Auris Nasus Larynx　45　(2)　351-357　2018/04/01
Publisher: Elsevier Ireland Ltd
DOI： 10.1016/j.anl.2017.03.019 　

ISSN： 1879-1476 0385-8146
Novel application of a rigid curved larygno-pharyngoscope for examination and treatment of hypopharyngeal lesions Peer-reviewed

Kenichi Watanabe, Daisuke Yamauchi, Yoshitaka Takanashi, Hiroshi Hidaka, Yukio Katori

Auris Nasus Larynx　45　(2)　367-370　2018/04
Publisher: Elsevier BV
DOI： 10.1016/j.anl.2017.04.006 　

ISSN： 0385-8146
Simple laryngeal suspension procedure by suturing the digastric muscle to the periosteum of the mandible in neck dissection for tongue cancer International-journal Peer-reviewed

Akira Ohkoshi, Takenori Ogawa, Shun Sagai, Ayako Nakanome, Kenjiro Higashi, Ryo Ishii, Kengo Kato, Yukio Katori

American Journal of Otolaryngology　39　(2)　77-81　2018/03
Publisher: Elsevier BV
DOI： 10.1016/j.amjoto.2018.01.008 　

ISSN： 0196-0709

eISSN： 1532-818X
Infantile hemangiopericytoma of the tongue—Efficacy of ex utero intrapartum treatment procedure and combined-modality therapy Peer-reviewed

Takenori Ogawa, Ryo Ishii, Daiki Ozawa, Takeshi Rikiishi, Hajime Usubuchi, Mika Watanabe, Yoshimichi Imai, Kenichi Sato, Masatoshi Saito, Yoji Sasahara, Tadashi Matsuda, Shigeo Kure, Yukio Katori

Auris Nasus Larynx　45　(1)　186-189　2018/02
Publisher: Elsevier BV
DOI： 10.1016/j.anl.2017.02.009 　

ISSN： 0385-8146

eISSN： 1879-1476
The efficacy of the Eustachian Tube Dysfunction Questionnaire (ETDQ-7) for patulous Eustachian tube patient Peer-reviewed

Ryoukichi Ikeda, Toshiaki Kikuchi, Hiromitsu Miyazaki, Hiroshi Hidaka, Tetsuaki Kawase, Yukio Katori, Toshimitsu Kobayashi

Acta Oto-Laryngologica　138　(1)　6-9　2018/01/02

DOI： 10.1080/00016489.2017.1366053 　

ISSN： 0001-6489

eISSN： 1651-2251
Anatomy of the posterior and middle ethmoidal arteries via computed tomography. Peer-reviewed

Yamamoto H, Nomura K, Hidaka H, Katori Y, Yoshida N

SAGE open medicine　6　2050312118772473　2018

DOI： 10.1177/2050312118772473 　
Steroid pulse therapy transiently destroys the discriminative histological structure of tonsils in IgA nephropathy: Tonsillectomy should be performed before or just after steroid pulse therapy Peer-reviewed

Mika Adachi, Mitsuhiro Sato, Mariko Miyazaki, Osamu Hotta, Koji Hozawa, Toshinobu Sato, Yoshio Taguma, Yukio Katori

Auris Nasus Larynx　45　(6)　1206-1213　2018
Publisher: Elsevier Ireland Ltd
DOI： 10.1016/j.anl.2018.04.009 　

ISSN： 1879-1476 0385-8146
Bath plug closure method for cerebrospinal fluid leakage by endoscopic endonasal approach cooperative treatment by neurosurgeons and otolaryngologists Peer-reviewed

Tomohiro Kawaguchi, Kazuya Arakawa, Kazuhiro Nomura, Yoshikazu Ogawa, Yukio Katori, Teiji Tominaga

Neurological Surgery　45　(12)　1067-1073　2017/12/01
Publisher: Igaku-Shoin Ltd
DOI： 10.11477/mf.1436203648 　

ISSN： 1882-1251 0301-2603
Reply to commentary to: factors influencing endoscopic dacryocystorhinostomy outcome Peer-reviewed

Kazuhiro Nomura, Kazuya Arakawa, Mitsuru Sugawara, Hiroshi Hidaka, Jun Suzuki, Yukio Katori

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY　274　(12)　4263-4263　2017/12

DOI： 10.1007/s00405-017-4710-9 　

ISSN： 0937-4477

eISSN： 1434-4726
Risk factors for delayed oral dietary intake in patients with deep neck infections including descending necrotizing mediastinitis Peer-reviewed

Hiroshi Hidaka, Daiki Ozawa, Shinichi Kuriyama, Taku Obara, Toru Nakano, Risako Kakuta, Kazuhiro Nomura, Kenichi Watanabe, Yukio Katori

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY　274　(11)　3951-3958　2017/11

DOI： 10.1007/s00405-017-4716-3 　

ISSN： 0937-4477

eISSN： 1434-4726
Five-year history of dysphagia as a sole initial symptom in inclusion body myositis Peer-reviewed

Saori Shibata, Rumiko Izumi, Tomonori Hara, Ryuji Ohshima, Naoko Nakamura, Naoki Suzuki, Hiroshi Kuroda, Masashi Aoki, Kengo Kato, Yukio Katori, Maki Tateyama

JOURNAL OF THE NEUROLOGICAL SCIENCES　381　325-327　2017/10

DOI： 10.1016/j.jns.2017.09.014 　

ISSN： 0022-510X

eISSN： 1878-5883
Patulous Eustachian Tube and Otitis Media With Effusion as Complications After Trigeminal Nerve Injury Peer-reviewed

Ryoukichi Ikeda, Toshimitsu Kobayashi, Masayuki Yoshida, Naohiro Yoshida, Toshiaki Kikuchi, Takeshi Oshima, Tetsuaki Kawase, Yukio Katori

OTOLOGY & NEUROTOLOGY　38　(8)　1125-1128　2017/09

DOI： 10.1097/MAO.0000000000001492 　

ISSN： 1531-7129

eISSN： 1537-4505
Endovascular Treatment for carotid blowout syndrome after radiation for esophageal cancer: A case report Peer-reviewed

Shigefumi Takahashi, Tomohiro Kawaguchi, Kuniyasu Nhzuma, Atsuhiro Nakagawa, Miki Fujimura, Takenori Ogawa, Yukio Katori, Teiji Tominaga

Neurological Surgery　45　(9)　791-798　2017/09/01
Publisher: Igaku-Shoin Ltd
DOI： 10.11477/mf.1436203594 　

ISSN： 1882-1251 0301-2603

eISSN： 1882-1251
How I do it: underwater endoscopic ear surgery for plugging in superior canal dehiscence syndrome

D. Yamauchi, Y. Hara, H. Hidaka, T. Kawase, Y. Katori

JOURNAL OF LARYNGOLOGY AND OTOLOGY　131　(8)　745-748　2017/08

DOI： 10.1017/S0022215117001104 　

ISSN： 0022-2151

eISSN： 1748-5460
Fetal facial nerve course in the ear region revisited Peer-reviewed

Zhe Wu Jin, Kwang Ho Cho, Hiroshi Abe, Yukio Katori, Gen Murakami, Jose Francisco Rodriguez-Vazquez

SURGICAL AND RADIOLOGIC ANATOMY　39　(8)　885-895　2017/08

DOI： 10.1007/s00276-017-1818-y 　

ISSN： 0930-1038

eISSN： 1279-8517
Clinical and bacteriological differences of deep neck infection in pediatric and adult patients: Review of 123 cases Peer-reviewed

Yuichi Shimizu, Hiroshi Hidaka, Daiki Ozawa, Risako Kakuta, Kazuhiro Nomura, Hisakazu Yano, Ken-ichi Watanabe, Yukio Katori

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY　99　95-99　2017/08

DOI： 10.1016/j.ijporl.2017.05.028 　

ISSN： 0165-5876

eISSN： 1872-8464
Factors influencing endoscopic dacryocystorhinostomy outcome Peer-reviewed

Kazuhiro Nomura, Kazuya Arakawa, Mitsuru Sugawara, Hiroshi Hidaka, Jun Suzuki, Yukio Katori

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY　274　(7)　2773-2777　2017/07

DOI： 10.1007/s00405-017-4541-8 　

ISSN： 0937-4477

eISSN： 1434-4726
Sonotubometric Assessment for Severity of Patulous Eustachian Tube Peer-reviewed

Iori Takata, Ryoukichi Ikeda, Tetsuaki Kawase, Yoko Suzuki, Takeshi Sato, Yukio Katori, Toshimitsu Kobayashi

OTOLOGY & NEUROTOLOGY　38　(6)　846-852　2017/07

DOI： 10.1097/MAO.0000000000001413 　

ISSN： 1531-7129

eISSN： 1537-4505
New Scoring System for Evaluating Patulous Eustachian Tube Patients Peer-reviewed

Ryoukichi Ikeda, Toshiaki Kikuchi, Hidetoshi Oshima, Hiromitsu Miyazaki, Hiroshi Hidaka, Tetsuaki Kawase, Yukio Katori, Toshimitsu Kobayashi

OTOLOGY & NEUROTOLOGY　38　(5)　708-713　2017/06

DOI： 10.1097/MAO.0000000000001370 　

ISSN： 1531-7129

eISSN： 1537-4505
Enteric neurons of the esophagus: an immunohistochemical study using donated elderly cadavers Peer-reviewed

Ai Hirano-Kawamoto, Yohei Honkura, Yuta Kobayashi, Gen Murakami, Shin-ichi Abe, Yukio Katori

SURGICAL AND RADIOLOGIC ANATOMY　39　(5)　477-484　2017/05

DOI： 10.1007/s00276-016-1799-2 　

ISSN： 0930-1038

eISSN： 1279-8517
Effectiveness of Kobayashi plug for 252 ears with chronic patulous Eustachian tube Peer-reviewed

Toshiaki Kikuchi, Ryoukichi Ikeda, Hidetoshi Oshima, Iori Takata, Tetsuaki Kawase, Takeshi Oshima, Yukio Katori, Toshimitsu Kobayashi

ACTA OTO-LARYNGOLOGICA　137　(3)　253-258　2017/03

DOI： 10.1080/00016489.2016.1231420 　

ISSN： 0001-6489

eISSN： 1651-2251
Osteoid osteoma of the temporal bone manifesting as first bite syndrome and a meta-analysis combined with osteoblastoma Peer-reviewed

Hiroshi Hidaka, Daisuke Yamauchi, Fumiyoshi Fujishima, Mika Watanabe, Yumiko Kato, Kazuhiro Nomura, Kenichi Watanabe, Tetsuaki Kawase, Yukio Katori

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY　274　(2)　607-616　2017/02

DOI： 10.1007/s00405-016-4050-1 　

ISSN： 0937-4477

eISSN： 1434-4726
Hernia of the tympanic membrane Peer-reviewed

Ryoukichi Ikeda, Hiromitsu Miyazaki, Tetsuaki Kawase, Yukio Katori, Toshimitsu Kobayashi

AURIS NASUS LARYNX　44　(1)　119-121　2017/02

DOI： 10.1016/j.an1.2016.04.009 　

ISSN： 0385-8146

eISSN： 1879-1476
Tubal function tests with optional myringotomy detect Eustachian tube closing failure in acquired pars flaccida retraction cholesteatoma Peer-reviewed

Phawana Asawapittayanont, Ryoukichi Ikeda, Hidetoshi Oshima, Toshiaki Kikuchi, Hiromitsu Miyazaki, Tetsuaki Kawase, Yukio Katori, Toshimitsu Kobayashi

AURIS NASUS LARYNX　44　(1)　65-69　2017/02

DOI： 10.1016/j.an1.2016.06.011 　

ISSN： 0385-8146

eISSN： 1879-1476
Computed tomography findings of the bony portion of the Eustachian tube with or without patulous Eustachian tube patients Peer-reviewed

Ryoukichi Ikeda, Toshiaki Kikuchi, Hidetoshi Oshima, Hiromitsu Miyazaki, Hiroshi Hidaka, Tetsuaki Kawase, Yukio Katori, Toshimitsu Kobayashi

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY　274　(2)　781-786　2017/02

DOI： 10.1007/s00405-016-4383-9 　

ISSN： 0937-4477

eISSN： 1434-4726
Morphology and relationships of ultimobranchial body with pharyngeal pouches

Masahito Yamamoto, Yohei Honkura, Jose F. Rodríguez-Vázquez, Gens Murakami, Yukio Katori, Shin Ichi Abe

European Journal of Anatomy　21　(2)　119-124　2017/01/01

ISSN： 1136-4890
Predicting postoperative fever and bacterial colonization on packing material following endoscopic endonasal surgery Peer-reviewed

Kazuhiro Nomura, Yurika Yamanaka, Yasuhiro Sekine, Hiroki Yamamoto, Yoshihiko Esu, Mariko Hara, Masayo Hasegawa, Akihiro Shinnabe, Hiromi Kanazawa, Risako Kakuta, Daiki Ozawa, Hiroshi Hidaka, Yukio Katori, Naohiro Yoshida

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY　274　(1)　167-173　2017/01

DOI： 10.1007/s00405-016-4189-9 　

ISSN： 0937-4477

eISSN： 1434-4726
Nasolacrimal duct opening to the inferior nasal meatus in human fetuses. Peer-reviewed

Yohei Honkura, Yoshitaka Takanashi, Ai Kawamoto-Hirano, Hiroshi Abe, Hajime Osanai, Gen Murakami, Yukio Katori

Okajimas folia anatomica Japonica　94　(3)　101-108　2017

DOI： 10.2535/ofaj.94.101 　

ISSN： 0030-154X

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The purpose of this study is to describe the Hasner's membrane which is the main factor of congenital nasolacrimal duct obstruction. Hasner's membrane at the nasal end of the fetal nasolacrimal duct (NLD) is considered to rupture at and after birth. However, topographical anatomy around the membrane as well as a mechanism of rupture seems to be still obscure. We observed frontal or sagittal sections of 20 late-stage fetuses (28-33 weeks) and found the on-going rupture in 2 specimens. The present sections demonstrated that 1) the nasal dilation was not a simple ball-like structure but extended posteriorly and laterally; 2) dilation of the NLD consistently involved the lacrimal sac; 3) Hasner's membrane and ductal mucosal layer contained no macrophages and no or few arteries and nerves. The posterior extension of the NLD end ranged from 1-2 mm, while the lateral extension 3-5 mm although a site of the thinnest membrane varied in location between specimens. Moreover, the thickest NLD due to dilation was in the slightly orbital or upper side of the nasal end. Therefore, before surgical treatment of Hasner's membrane, evaluation using medical images seems to be necessary. Since the nasal epithelium on Hasner's membrane was most likely to destroy earlier than the NLD mucosal lining, observations of the membrane from the nasal cavity seemed helpful for diagnosis at which site would be broken and when.
Hammer sound elicited tinnitus in car body repair worker cured by stapedial tenotomy - A case report Peer-reviewed

Ryoukichi Ikeda, Hiroshi Hidaka, Hiromitsu Miyazaki, Tetsuaki Kawase, Yukio Katori, Toshimitsu Kobayashi

AURIS NASUS LARYNX　43　(6)　689-692　2016/12

DOI： 10.1016/j.anl.2016.03.005 　

ISSN： 0385-8146

eISSN： 1879-1476
First report of severe acute otitis media caused by Campylobacter rectus and review of the literature Peer-reviewed

Risako Kakuta, Hiroshi Hidaka, Hisakazu Yano, Michiko Okamoto, Daiki Ozawa, Shiro Endo, Mitsuo Kaku, Yukio Katori

JOURNAL OF INFECTION AND CHEMOTHERAPY　22　(12)　800-803　2016/12

DOI： 10.1016/j.jiac.2016.06.001 　

ISSN： 1341-321X

eISSN： 1437-7780
Impact of Audio-Visual Asynchrony on Lip-Reading Effects -Neuromagnetic and Psychophysical Study- Peer-reviewed

Tetsuaki Kawase, Izumi Yahata, Akitake Kanno, Shuichi Sakamoto, Yoshitaka Takanashi, Shiho Takata, Nobukazu Nakasato, Ryuta Kawashima, Yukio Katori

PLOS ONE　11　(12)　e0168740　2016/12

DOI： 10.1371/journal.pone.0168740 　

ISSN： 1932-6203
Macrophage infiltration into thyroid follicles: An immunohistochemical study using donated elderly cadavers Peer-reviewed

Takeshi Takayama, Ai Hirano-Kawamoto, Masahito Yamamoto, Gen Murakami, Yukio Katori, Kei Kitamura, Shin-Ichi Abe

Okajimas Folia Anatomica Japonica　93　(3)　73-80　2016/11/01
Publisher: Okajima Foria Anatomica Yaponika Henshubu
DOI： 10.2535/ofaj.93.73 　

ISSN： 1881-1736 0030-154X
Cricothyroid Articulation in Elderly Japanese With Special Reference to Morphology of the Synovial and Capsular Tissues Peer-reviewed

Ai Kawamoto, Yohei Honkura, Ryoji Suzuki, Hiroshi Abe, Shin-ichi Abe, Gen Murakami, Yukio Katori

JOURNAL OF VOICE　30　(5)　538-548　2016/09

DOI： 10.1016/j.jvoice.2015.07.011 　

ISSN： 0892-1997

eISSN： 1873-4588
Clinicopathological features of melanotic neuroectodermal tumor of infancy: Report of two cases Peer-reviewed

Kenjiro Higashi, Takenori Ogawa, Masaei Onuma, Hajime Usubuchi, Yoshimichi Imai, Iori Takata, Hiroshi Hidaka, Mika Watanabe, Yoji Sasahara, Shigeto Koyama, Shigeo Kure, Yukio Katori

AURIS NASUS LARYNX　43　(4)　451-454　2016/08

DOI： 10.1016/j.anl.2015.10.010 　

ISSN： 0385-8146

eISSN： 1879-1476
Transient Hearing Loss and Objective Tinnitus Induced by Mouth Opening: A Rare Connection Between the Temporomandibular Joint and Middle Ear Space Peer-reviewed

Hiroshi Hidaka, Yasuko Tatewaki, Maya Sakamoto, Toshimitsu Kobayashi, Yu Yuasa, Ryo Yuasa, Kazuhiro Nomura, Daisuke Yamauchi, Yukio Katori

OTOLOGY & NEUROTOLOGY　37　(7)　E217-E221　2016/08

DOI： 10.1097/MAO.0000000000001078 　

ISSN： 1531-7129

eISSN： 1537-4505
The cricothyroid joint in elderly Japanese individuals Peer-reviewed

Masamitu Serikawa, Masahito Yamamoto, Ai Kawamoto, Yukio Katori, Hideaki Kinoshita, Satoru Matsunaga, Shin-ichi Abe

ANATOMICAL SCIENCE INTERNATIONAL　91　(3)　250-257　2016/06

DOI： 10.1007/s12565-015-0294-x 　

ISSN： 1447-6959

eISSN： 1447-073X
Effect of intratympanic application of efinaconazole 10 % solution in the guinea pig Peer-reviewed

Kazuya Arakawa, Kazuhiro Nomura, Hidetoshi Oshima, Yohei Honkura, Ryoukichi Ikeda, Hiroshi Hidaka, Tetsuaki Kawase, Yukio Katori

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY　273　(5)　1137-1142　2016/05

DOI： 10.1007/s00405-015-3669-7 　

ISSN： 0937-4477

eISSN： 1434-4726
Molecular Epidemiology of Ampicillin-resistant Haemophilus influenzae Causing Acute Otitis Media in Japanese Infants and Young Children Peer-reviewed

Risako Kakuta, Hisakazu Yano, Hiroshi Hidaka, Hajime Kanamori, Shiro Endo, Sadahiro Ichimura, Miho Ogawa, Masahiro Shimojima, Daiki Ozawa, Shinya Inomata, Ayako Tanouchi, Mitsuo Kaku, Yukio Katori

PEDIATRIC INFECTIOUS DISEASE JOURNAL　35　(5)　501-506　2016/05

DOI： 10.1097/INF.0000000000001066 　

ISSN： 0891-3668

eISSN： 1532-0987
Synovial tissue morphology of the cricoarytenoid joint in the elderly: A histological comparison with the cricothyroid joint Peer-reviewed

Sakura Katsumura, Masahito Yamamoto, Kei Kitamura, Masaaki Kasahara, Yukio Katori, Shin-Ichi Abe

Anatomy and Cell Biology　49　(1)　61-67　2016/03/01
Publisher: Korean Association of Anatomists
DOI： 10.5115/acb.2016.49.1.61 　

ISSN： 2093-3673 2093-3665
Nasal cavity epithelioid hemangioendothelioma invading the anterior skull base. International-journal Peer-reviewed

Shogo Ogita, Toshiki Endo, Kazuhiro Nomura, Takenori Ogawa, Mika Watanabe, Kenjiro Higashi, Yukio Katori, Teiji Tominaga

Surgical neurology international　7　53-53　2016

DOI： 10.4103/2152-7806.181902 　

ISSN： 2229-5097

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BACKGROUND: Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor that frequently occurs in soft tissues. Patients suffer from local recurrence and remote metastasis because of its malignant potential. Here, we present a rare case of EHE that originated from nasal cavity and invaded intracranially through the anterior skull base. CASE DESCRIPTION: This is a 27-year-old woman who presented a local physician with intermittent epistaxis and a facial pain around her nose. Preoperative studies demonstrated that the tumor invaded into anterior skull base and the dura matter. Therefore, we performed combined skull base and transnasal surgery, which achieved complete resection of the tumor. Postoperative course of the patient was uneventful. No recurrence or distant metastasis was observed in the patient for 2 years following the radical resection. CONCLUSIONS: To date, four cases of EHE in the nasal cavity were reported. This is the first case in which EHE demonstrated invasive potentials with intracranial extension. Radical surgical resection plays an important role for better management of invasive paranasal EHE.
Macrophage density in pharyngeal and laryngeal muscles greatly exceeds that in other striated muscles: An immunohistochemical study using elderly human cadavers Peer-reviewed

Sunki Rhee, Masahito Yamamoto, Kei Kitamura, Kasahara Masaaki, Yukio Katori, Gen Murakami, Shin-ichi Abe

Anatomy and Cell Biology　49　(3)　177-183　2016
Publisher: Korean Association of Anatomists
DOI： 10.5115/acb.2016.49.3.177 　

ISSN： 2093-3673 2093-3665
Is the ultimobranchial body a reality or myth: a study using serial sections of human embryos. Peer-reviewed

Yohei Honkura, Masahito Yamamoto, Toshihito Yoshimoto, Jose Francisco Rodriguez-Vazquez, Gen Murakami, Yukio Katori, Shin-Ichi Abe

Okajimas folia anatomica Japonica　93　(2)　29-40　2016

DOI： 10.2535/ofaj.93.29 　

ISSN： 0030-154X

eISSN： 1881-1736

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Reported morphologies of the ultimobranchial body had varied between researchers: a cluster of mitotic cells, a duct-like structure and a rosette-like cell mass. To clarify the true morphology, we studied tilted horizontal sections of 20 human embryos (crown-rump length 5-18 mm; 4-6 weeks). The sections displayed a ladder-like arrangement of the second to fourth endodermal pouches and, in 5 early embryos we found the fifth pouch attached to the fifth ectodermal groove near the fourth pharyngeal arch artery. The bilateral fifth pharyngeal pouches protruded anterolaterally to form a U-shaped lumen surrounding the arytenoid swelling. The third to fifth pouches were each characterized by a pedal-shaped inferior end. We identified several types of cell clusters as candidates for the ultimobranchial body, but morphologically most of them were, to various degrees, likely to correspond to the blind end of the lower pouch when cut tangentially. Because of the topographical relation to the common carotid artery, a cyst-like structure with a cell cluster seemed to be the most likely candidate of the ultimobranchial body (a common anlage of the thymus and parathyroid). However, we were not able to deny a possibility that a certain plane cutting the pouch end incidentally provided such a cyst-like structure in sections. At any stage, the ultimobranchial body might not appear as a definite structure that is discriminated from others with routine staining. A concept of the ultimobranchial body might be biased by comparative anatomy that shows the ultimobranchial gland in adult birds and reptiles.
Endoscopic surgical management of sinonasal inverted papilloma extending to frontal sinuses Peer-reviewed

Nobuo Ohta, Yusuke Suzuki, Yasuhiro Abe, Naoya Noguchi, Takahiro Suzuki, Risako Kakuta, Fumi Shoji, Yukiko Takahashi, Hiroshi Hidaka, Yukio Katori, Seiji Kakehata, Yoshitaka Okamoto

Otolaryngologia Polska　70　(6)　26-31　2016
Publisher: Polish Otolaryngology Society
DOI： 10.5604/01.3001.0009.3801 　

ISSN： 0030-6657
Minimally Invasive Treatment for Hard Palate-Invading Maxillary Keratocystic Odontogenic Tumor Peer-reviewed

Kazuhiro Nomura, Kazuya Arakawa, Fumiyoshi Fujishima, Yuto Yamazaki, Daiki Ozawa, Yuri Nomura, Hiroshi Hidaka, Naohiro Yoshida, Yukio Katori

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　237　(4)　267-272　2015/12

DOI： 10.1620/tjem.237.267 　

ISSN： 0040-8727

eISSN： 1349-3329
Impact of the Seven-valent Pneumococcal Conjugate Vaccine on Acute Otitis Media in Japanese Children Emergence of Serotype 15A Multidrug-resistant Streptococcus pneumoniae in Middle Ear Fluid Isolates Peer-reviewed

Daiki Ozawa, Hisakazu Yano, Shiro Endo, Hiroshi Hidaka, Risako Kakuta, Naohiro Okitsu, Hajime Kanamori, Miho Ogawa, Sadahiro Ichimura, Masahiro Shimojima, Shinya Inomata, Mitsuo Kaku, Yukio Katori

PEDIATRIC INFECTIOUS DISEASE JOURNAL　34　(9)　E217-E221　2015/09

DOI： 10.1097/INF.0000000000000776 　

ISSN： 0891-3668

eISSN： 1532-0987
Factors Affecting the Variation of Maximum Speech Intelligibility in Patients With Sensorineural Hearing Loss Other Than Apparent Retrocochlear Lesions Peer-reviewed

Izumi Yahata, Tetsuaki Kawase, Hiromitsu Miyazaki, Yusuke Takata, Daisuke Yamauchi, Kazuhiro Nomura, Yukio Katori

CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY　8　(3)　189-193　2015/09

DOI： 10.3342/ceo.2015.8.3.189 　

ISSN： 1976-8710

eISSN： 2005-0720
Minimally invasive transnasal approach to infratemporal fossa abscess

K. Nomura, H. Hidaka, Y. Takata, Y. Katori

JOURNAL OF LARYNGOLOGY AND OTOLOGY　129　(8)　812-816　2015/08

DOI： 10.1017/S0022215115001541 　

ISSN： 0022-2151

eISSN： 1748-5460
Outcomes of frontal mucoceles treated with conventional endoscopic sinus surgery Peer-reviewed

Kazuhiro Nomura, Hiroshi Hidaka, Kazuya Arakawa, Mitsuru Sugawara, Daiki Ozawa, Yuri Okumura, Yusuke Takata, Yukio Katori

ACTA OTO-LARYNGOLOGICA　135　(8)　819-823　2015/08

DOI： 10.3109/00016489.2015.1021933 　

ISSN： 0001-6489

eISSN： 1651-2251
Intraoral drainage under surgical microscopy with tonsillectomy for parapharyngeal abscesses

Y. Okumura, H. Hidaka, N. Noguchi, Y. Katori

JOURNAL OF LARYNGOLOGY AND OTOLOGY　129　(6)　595-597　2015/06

DOI： 10.1017/S0022215115000791 　

ISSN： 0022-2151

eISSN： 1748-5460
Clinical factors indicating the presence of malignant lymphoma before lymph node dissection Peer-reviewed

Yuri Okumura, Kazuhiro Nomura, Toshiaki Kikuchi, Takahiro Suzuki, Hiroshi Hidaka, Takenori Ogawa, Yukio Katori

ACTA OTO-LARYNGOLOGICA　135　(5)　513-518　2015/05

DOI： 10.3109/00016489.2014.993088 　

ISSN： 0001-6489

eISSN： 1651-2251
Change in and Long-Term Investigation of Neuro-Otologic Disorders in Disaster-Stricken Fukushima Prefecture: Retrospective Cohort Study before and after the Great East Japan Earthquake Peer-reviewed

Jun Hasegawa, Hiroshi Hidaka, Shinichi Kuriyama, Taku Obara, Ken Hashimoto, Yutaka Tateda, Yuri Okumura, Toshimitsu Kobayashi, Yukio Katori

PLOS ONE　10　(4)　e0122631　2015/04

DOI： 10.1371/journal.pone.0122631 　

ISSN： 1932-6203
Endoscopic balloon dilatation for pharyngo-upper esophageal stricture after treatment of head and neck cancer Peer-reviewed

Ryuhei Maejima, Katsunori Iijima, Tomoyuki Koike, Nobuyuki Ara, Kaname Uno, Waku Hatta, Takenori Ogawa, Ken-ichi Watanabe, Yukio Katori, Tooru Shimosegawa

DIGESTIVE ENDOSCOPY　27　(3)　310-316　2015/03

DOI： 10.1111/den.12345 　

ISSN： 0915-5635

eISSN： 1443-1661
Unique Migration of a Dental Needle Into the Parapharyngeal Space: Successful Removal by an Intraoral Approach and Simulation for Tracking Visibility in X-ray Fluoroscopy Peer-reviewed

Yuri Okumura, Hiroshi Hidaka, Kazumasa Seiji, Kazuhiro Nomura, Yusuke Takata, Takahiro Suzuki, Yukio Katori

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY　124　(2)　162-167　2015/02

DOI： 10.1177/0003489414547106 　

ISSN： 0003-4894

eISSN： 1943-572X
Bilateral endoscopic endonasal marsupialization of nasopalatine duct cyst. International-journal Peer-reviewed

Yohei Honkura, Kazuhiro Nomura, Hidetoshi Oshima, Yusuke Takata, Hiroshi Hidaka, Yukio Katori

Clinics and practice　5　(1)　748-748　2015/01/28

DOI： 10.4081/cp.2015.748 　

ISSN： 2039-7275

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Nasopalatine duct cysts are the most common non-odontogenic cysts in the maxilla, and are conventionally treated through a sublabial or palatine approach. Recently, the endoscopic approach has been used, but experience is extremely limited. We treated a 29-year-old male with nasopalatine duct cyst by endoscopic marsupialization, but paresthesia of the incisor region occurred after surgery. This paresthesia gradually remitted within 6 months. The nasopalatine nerve, which innervates the upper incisor region, enters two lateral canals separately at the nasal floor and exits the central main canal at the palate. Damage to the bilateral nasopalatine nerves might lead to paresthesia, so we recommend careful examination for nerve fibers during endoscopic surgery, especially if fenestration is performed on both sides.
Importance of visual cues in hearing restoration by auditory prosthesis

Tetsuaki Kawase, Takenori Ogawa, Yukio Katori

Interface Oral Health Science 2014: Innovative Research on Biosis-Abiosis Intelligent Interface　119-127　2015/01/01
Publisher: Springer Japan
DOI： 10.1007/978-4-431-55192-8_10 　
Pyramidal lobe of the thyroid gland and the thyroglossal duct remnant: A study using human fetal sections Peer-reviewed

Yoshitaka Takanashi, Yohei Honkura, Jose Francisco Rodriguez-Vazquez, Gen Murakami, Tetsuaki Kawase, Yukio Katori

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER　197　29-37　2015

DOI： 10.1016/j.aanat.2014.09.001 　

ISSN： 0940-9602

eISSN： 1618-0402
Innervation of submandibular and sublingual glands in elderly donated cadavers: A preliminary histological study of differences in nerve morphology between mucous and serous acini Peer-reviewed

Sachiko Asakawa, Masahito Yamamoto, Yukio Katori, Gen Murakami, Masaaki Kasahara, Satoru Matsunaga, Shin-Ichi Abe

Anatomy and Cell Biology　48　(1)　36-43　2015
Publisher: Korean Association of Anatomists
DOI： 10.5115/acb.2015.48.1.36 　

ISSN： 2093-3673 2093-3665
Morphological differences in innervation between mucous glands and serous glands: a quantitative histological study using the sublingual glands of elderly humans Peer-reviewed

Ai Kawamoto, Kei Kitamura, Masahito Yamamoto, Gen Murakami, Shin-ichi Abe, Yukio Katori

ACTA OTO-LARYNGOLOGICA　135　(9)　942-949　2015

DOI： 10.3109/00016489.2015.1034878 　

ISSN： 0001-6489

eISSN： 1651-2251
Clinical factors indicating short nasal bone overlap Peer-reviewed

Yuri Nomura, Kazuhiro Nomura, Daiki Ozawa, Kazuya Arakawa, Hiroshi Hidaka, Yukio Katori

ACTA OTO-LARYNGOLOGICA　135　(11)　1196-1199　2015

DOI： 10.3109/00016489.2015.1061698 　

ISSN： 0001-6489

eISSN： 1651-2251
Audiological evidence of therapeutic effect of steroid treatment in neuromyelitis optica with hearing loss Peer-reviewed

Yoshitaka Takanashi, Tatsuro Misu, Kazuha Oda, Hiromitsu Miyazaki, Izumi Yahata, Hiroshi Hidaka, Kazuo Fujihara, Tetsuaki Kawase, Toshimitsu Kobayashi, Yukio Katori

JOURNAL OF CLINICAL NEUROSCIENCE　21　(12)　2249-2251　2014/12

DOI： 10.1016/j.jocn.2014.04.019 　

ISSN： 0967-5868

eISSN： 1532-2653
Ototoxic Effect of Ultrastop Antifog Solution Applied to the Guinea Pig Middle Ear Peer-reviewed

Kazuhiro Nomura, Hidetoshi Oshima, Daisuke Yamauchi, Hiroshi Hidaka, Tetsuaki Kawase, Yukio Katori

OTOLARYNGOLOGY-HEAD AND NECK SURGERY　151　(5)　840-844　2014/11

DOI： 10.1177/0194599814545749 　

ISSN： 0194-5998

eISSN： 1097-6817
Twelve-year survey (2001-2012) of the antimicrobial susceptibility of Streptococcus pneumoniae isolates from otorhinolaryngology clinics in Miyagi Prefecture, Japan Peer-reviewed

Daiki Ozawa, Hisakazu Yano, Hiroshi Hidaka, Risako Kakuta, Mayumi Komatsu, Shiro Endo, Hajime Kanamori, Mitsuo Kaku, Yukio Katori

JOURNAL OF INFECTION AND CHEMOTHERAPY　20　(11)　702-708　2014/11

DOI： 10.1016/j.jiac.2014.07.014 　

ISSN： 1341-321X

eISSN： 1437-7780
Helicobacter cinaedi Infection of Abdominal Aortic Aneurysm, Japan Peer-reviewed

Risako Kakuta, Hisakazu Yano, Hajime Kanamori, Takuya Shimizu, Yoshiaki Gu, Masumitsu Hatta, Tetsuji Aoyagi, Shiro Endo, Shinya Inomata, Chihiro Oe, Koichi Tokuda, Daiki Ozawa, Hitoshi Goto, Yukio Katori, Mitsuo Kaku

EMERGING INFECTIOUS DISEASES　20　(11)　1942-1945　2014/11

DOI： 10.3201/eid2011.140440 　

ISSN： 1080-6040

eISSN： 1080-6059
Ototoxic effect of daptomycin applied to the guinea pig middle ear Peer-reviewed

Hidetoshi Oshima, Kazuhiro Nomura, Muneharu Yamazaki, Jun Suzuki, Tetsuaki Kawase, Toshimitsu Kobayashi, Yukio Katori

ACTA OTO-LARYNGOLOGICA　134　(7)　679-683　2014/07

DOI： 10.3109/00016489.2014.898186 　

ISSN： 0001-6489

eISSN： 1651-2251
Endoscopic Drainage of Orbital Subperiosteal Hematoma Secondary to Acute Rhinosinusitis in a Child Peer-reviewed

Kazuhiro Nomura, Yohei Honkura, Daiki Ozawa, Yuri Okumura, Hiroshi Hidaka, Takenori Ogawa, Daisuke Yamauchi, Kenichi Watanabe, Yukio Katori

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　233　(3)　171-174　2014/07

DOI： 10.1620/tjem.233.171 　

ISSN： 0040-8727

eISSN： 1349-3329
Effects of Contralateral Noise on the 20-Hz Auditory Steady State Response - Magnetoencephalography Study Peer-reviewed

Hajime Usubuchi, Tetsuaki Kawase, Akitake Kanno, Izumi Yahata, Hiromitsu Miyazaki, Nobukazu Nakasato, Ryuta Kawashima, Yukio Katori

PLOS ONE　9　(6)　e99457　2014/06

DOI： 10.1371/journal.pone.0099457 　

ISSN： 1932-6203
Dislocated dental bridge covering the larynx: usefulness of tracheal tube guides under video-assisted laryngoscopy for induction of general anesthesia, thus avoiding tracheostomy Peer-reviewed

Hiroshi Hidaka, Takahiro Suzuki, Hiroaki Toyama, Shin Kurosawa, Kazuhiro Nomura, Yukio Katori

HEAD & FACE MEDICINE　10　23　2014/06

DOI： 10.1186/1746-160X-10-23 　

ISSN： 1746-160X
Surgical treatment for the aberrant internal carotid artery in the middle ear with pulsatile tinnitus Peer-reviewed

Yohei Honkura, Hiroshi Hidaka, Jun Ohta, Shigeki Gorai, Yukio Katori, Toshimitsu Kobayashi

AURIS NASUS LARYNX　41　(2)　215-218　2014/04

DOI： 10.1016/j.anl.2013.10.002 　

ISSN： 0385-8146

eISSN： 1879-1476
Preservation of cochlear function in Fabp3 (H-Fabp) knockout mice Peer-reviewed

Jun Suzuki, Takeshi Oshima, Naohiro Yoshida, Ryuichi Kimura, Yusuke Takata, Yuji Owada, Toshimitsu Kobayashi, Yukio Katori, Noriko Osumi

NEUROSCIENCE RESEARCH　81-82　64-68　2014/04

DOI： 10.1016/j.neures.2014.02.003 　

ISSN： 0168-0102

eISSN： 1872-8111
Severe Acute Otitis Media Caused by Mucoid Streptococcus Pyogenes in a Previously Healthy Adult Peer-reviewed

Risako Kakuta, Hisakazu Yano, Hiroshi Hidaka, Hiromitsu Miyazaki, Mihoko Irimada, Kiyoshi Oda, Kazuaki Arai, Daiki Ozawa, Takashi Takahashi, Mitsuo Kaku, Yukio Katori

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　232　(4)　301-304　2014/04

DOI： 10.1620/tjem.232.301 　

ISSN： 0040-8727

eISSN： 1349-3329
Site-dependent differences in density of sympathetic nerve fibers in muscle-innervating nerves of the human head and neck Peer-reviewed

Fumio Hosaka, Yukio Katori, Tetsuaki Kawase, Mineko Fujimiya, Hiroshi Ohguro

ANATOMICAL SCIENCE INTERNATIONAL　89　(2)　101-111　2014/03

DOI： 10.1007/s12565-013-0205-y 　

ISSN： 1447-6959

eISSN： 1447-073X
Septal Deviation Is Associated with Maxillary Sinus Fungus Ball in Male Patients Peer-reviewed

Hidetoshi Oshima, Kazuhiro Nomura, Mitsuru Sugawara, Kazuya Arakawa, Takeshi Oshima, Yukio Katori

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　232　(3)　201-206　2014/03

DOI： 10.1620/tjem.232.201 　

ISSN： 0040-8727

eISSN： 1349-3329
Change in Endocochlear Potential During Experimental Insertion of a Simulated Cochlear Implant Electrode in the Guinea Pig Peer-reviewed

Hidetoshi Oshima, Ryoukichi Ikeda, Kazuhiro Nomura, Muneharu Yamazaki, Hiroshi Hidaka, Yukio Katori, Takeshi Oshima, Tetsuaki Kawase, Toshimitsu Kobayashi

OTOLOGY & NEUROTOLOGY　35　(2)　234-240　2014/02

DOI： 10.1097/MAO.0b013e3182a36018 　

ISSN： 1531-7129

eISSN： 1537-4505
Osteoma of the internal auditory canal mimicking vestibular schwannoma: case report and review of 17 recent cases. Peer-reviewed

Jun Suzuki, Yusuke Takata, Hiromitsu Miyazaki, Izumi Yahata, Yasuhiko Tachibana, Toshimitsu Kobayashi, Tetsuaki Kawase, Yukio Katori

The Tohoku journal of experimental medicine　232　(1)　63-8　2014/01

DOI： 10.1620/tjem.232.63 　

ISSN： 0040-8727

eISSN： 1349-3329

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Osteoma of the internal auditory canal (IAC) is an uncommon benign bone tumor. Its imaging features may be similar to other IAC lesions, such as vestibular schwannomas that are benign and usually slow-growing but sometimes life-threatening tumors. Thus, detecting IAC lesions and differentiating osteoma from other IAC lesions are both important clinically. We report a case of misdiagnosis of an IAC osteoma as an IAC schwannoma based on magnetic resonance (MR) imaging using the three-dimensional constructive interference in steady state (CISS) sequence instead of T1-weighted MR imaging with gadolinium. We also review 17 cases of IAC osteomas reported in the past 22 years. A 61-year-old female was admitted to our department with IAC lesion incidentally discovered by the CISS sequence. The lesion was diagnosed as an IAC schwannoma, and was followed up annually under "wait and scan" management. Follow-up T1-weighted MR imaging with gadolinium showed no enhancement of the tumor, and additional computed tomography (CT) of the temporal bone showed a solitary pedunculated bony lesion, resulting in the diagnosis of IAC osteoma. The CISS sequence is useful for detecting small IAC lesions, such as vestibular schwannomas. However, the CISS sequence has limitations for qualitative diagnosis and can misdiagnose osteomas as schwannomas. Use of the CISS sequence without T1-weighted MR imaging with gadolinium for the screening of a lesion of the IAC and cerebellopontine angle should consider the possibility of IAC osteomas, and temporal bone CT or T1-weighted MR imaging with gadolinium should be performed when an IAC lesion is detected.
Distribution of CD10-positive epithelial and mesenchymal cells in human mid-term fetuses: A comparison with CD34 expression Peer-reviewed

Ji Hyun Kim, Si Eun Hwang, Hee Chul Yu, Hong Pil Hwang, Yukio Katori, Gen Murakami, Baik Hwan Cho

Anatomy and Cell Biology　47　(1)　28-39　2014
Publisher: Korean Association of Anatomists
DOI： 10.5115/acb.2014.47.1.28 　

ISSN： 2093-3673 2093-3665
Association between Septal Deviation and Sinonasal Papilloma Peer-reviewed

Kazuhiro Nomura, Takenori Ogawa, Mitsuru Sugawara, Yohei Honkura, Hidetoshi Oshima, Kazuya Arakawa, Takeshi Oshima, Yukio Katori

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　231　(4)　315-319　2013/12

DOI： 10.1620/tjem.231.315 　

ISSN： 0040-8727

eISSN： 1349-3329
Logistic regression analysis of risk factors for prolonged pulmonary recovery in children from aspirated foreign body Peer-reviewed

Hiroshi Hidaka, Taku Obara, Shinichi Kuriyama, Shin Kurosawa, Yukio Katori, Toshimitsu Kobayashi

International Journal of Pediatric Otorhinolaryngology　77　(10)　1677-1682　2013/10

DOI： 10.1016/j.ijporl.2013.07.024 　

ISSN： 0165-5876 1872-8464
Osseous hamartoma arising from the eustachian tube. International-journal Peer-reviewed

Kawamoto A, Katori Y, Honkura Y, Ogura M, Oshima T, Kobayashi T

Clinics and practice　3　(2)　e25　2013/08

DOI： 10.4081/cp.2013.e25 　

ISSN： 2039-7275

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A fairly quite rare case of osseous tumor arising from the Eustachian tube (ET) is described. A 56-year-old man presented with a smooth bulky mass in the nasopharynx and secretory otitis media in the right ear. Computed tomography and magnetic resonance imaging indicated a solid tumor-like region occupying the nasopharynx with apparent extension to the right ET. Transnasal endoscopic surgery demonstrated that the tumor had originated from the ET, and the tumor was partially removed in the area where it had expanded into the nasopharynx. The pathological diagnosis was an osseous hamartoma consisting of bony tissue, fat cells and fibroblasts. To our knowledge, this is the first reported case of osseous hamartoma arising from the ET in the world literature. The patient presented symptoms of nasal obstruction and unilateral aural fullness. Reduction surgery and tympanostomy tube insertion were useful for accurate diagnosis and resolution of the symptoms.
Isolated Juvenile Xanthogranuloma in the Larynx of a Three-Year-Old Child Peer-reviewed

Ai Kawamoto, Yukio Katori, Yohei Honkura, Keiko Ishii, Masaki Ogura, Hiroshi Naganuma, Rie Shibuya, Takahiro Suzuki, Toshimitsu Kobayashi

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　230　(2)　123-127　2013/06

DOI： 10.1620/tjem.230.123 　

ISSN： 0040-8727

eISSN： 1349-3329
Heterogeneity of glandular cells in the human salivary glands: an immunohistochemical study using elderly adult and fetal specimens. International-journal Peer-reviewed

Katori Y, Hayashi S, Takanashi Y, Kim JH, Abe S, Murakami G, Kawase T

Anatomy & cell biology　46　(2)　101-112　2013/06

DOI： 10.5115/acb.2013.46.2.101 　

ISSN： 2093-3665

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Using immunohistochemical staining for alpha-smooth muscle actin (α-SMA), glial fibrillary acidic protein (GFAP), S100 protein (S100), p63, cytokeratin 14 (CK14), and cytokeratin 19 (CK19), we studied acinar and myoepithelial cells of major and minor salivary glands obtained from 14 donated cadavers (78-92 years old) and 5 donated fetuses (aborted at 15-16 weeks of gestation). CK and p63 expression was investigated only in the adult specimens. SMA was detected in all adult glands as well as in fetal sublingual and pharyngeal glands. GFAP expression was seen in a limited number of cells in adult glands, but was highly expressed in fetal pharyngeal glands. S100-positive myoepithelial-like cells were present in adult minor glands as well as in fetal sublingual and pharyngeal glands. Expression of p63 was evident in the ducts of adult glands. CK14 immunoreactivity was observed in a limited number of glandular cells in adults, in contrast to consistent expression of CK19. In both adults and fetuses, a mosaic expression pattern was usually evident for each of the examined proteins. A difference in immunoreactivity for the nerve markers GFAP and S100 was observed between the major and minor glands. Thus, in the present histologic study, we distinguished between the specific gland types on the basis of their immunohistochemical staining. A mosaic expression pattern suggested that the immunoreactivity against nerve protein markers in myoepithelial cells could not be due to the persistence of neural crest remnants or the physiological status of the gland, such as age-related degeneration.
Fetal anatomy of the upper pharyngeal muscles with special reference to the nerve supply: is it an enteric plexus or simply an intramuscular nerve? Peer-reviewed

Abe S, Fukuda M, Yamane S, Saka H, Katori Y, Rodríguez-Vázquez JF, Murakami G

Anatomy & cell biology　46　(2)　141-148　2013/06

DOI： 10.5115/acb.2013.46.2.141 　

ISSN： 2093-3665
A ganglion cell cluster along the glossopharyngeal nerve near the human palatine tonsil Peer-reviewed

Kazuha Oda, Yoshitaka Takanashi, Yukio Katori, Mineko Fujimiya, Gen Murakami, Tetsuaki Kawase

ACTA OTO-LARYNGOLOGICA　133　(5)　509-512　2013/05

DOI： 10.3109/00016489.2012.754997 　

ISSN： 0001-6489

eISSN： 1651-2251
Rathke's pouch remnant and its regression process in the prenatal period Peer-reviewed

Kwang Ho Cho, Hyuk Chang, Masahito Yamamoto, Hiroshi Abe, Jose Francisco Rodríguez-Vázquez, Gen Murakami, Yukio Katori

Child's Nervous System　29　(5)　761-769　2013/05

DOI： 10.1007/s00381-012-2015-2 　

ISSN： 0256-7040 1433-0350
Acquired idiopathic laryngomalacia treated by laser supraglottic laryngoplasty Peer-reviewed

Ai Kawamoto, Yukio Katori, Yohei Honkura, Masaki Ogura, Yoshitaka Takanashi, Toshimitsu Kobayashi

Tohoku Journal of Experimental Medicine　230　(1)　43-47　2013/05

DOI： 10.1620/tjem.230.43 　

ISSN： 0040-8727 1349-3329
Deep fat of the face revisited Peer-reviewed

Kwang Ho Cho, Hak Seung Lee, Yukio Katori, Jose Francisco Rodriguez-Vazquez, Gen Murakami, Shin-Ichi Abe

CLINICAL ANATOMY　26　(3)　347-356　2013/04

DOI： 10.1002/ca.22206 　

ISSN： 0897-3806
Fetal development and variations in the cartilages surrounding the human external acoustic meatus Peer-reviewed

Yasutoyo Ikari, Yukio Katori, Aiji Ohtsuka, Jose Francisco Rodriguez-Vazquez, Hiroshi Abe, Tetsuaki Kawase, Gen Murakami, Shin-ichi Abe

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER　195　(2)　128-136　2013

DOI： 10.1016/j.aanat.2012.07.009 　

ISSN： 0940-9602
Fetal development of the elastic-fiber-mediated enthesis in the human middle ear Peer-reviewed

Yoshitaka Takanashi, Shunichi Shibata, Yukio Katori, Gen Murakami, Shinichi Abe, Jose Francisco Rodriguez-Vazquez, Tetsuaki Kawase

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER　195　(5)　441-448　2013

DOI： 10.1016/j.aanat.2013.03.010 　

ISSN： 0940-9602

eISSN： 1618-0402
Frontal sinusitis with mixed bacterial colonies treated with the combination of endoscopic modified lothrop procedure and external approach. International-journal Peer-reviewed

Nomura K, Honkura Y, Okumura Y, Kasajima A, Suzuki T, Kikuchi T, Hidaka H, Oshima T, Katori Y

Case reports in otolaryngology　2013　541843-541843　2013

DOI： 10.1155/2013/541843 　

ISSN： 2090-6765

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Isolated frontal sinusitis with mixed bacterial colonies is extremely rare and has not been described. We report a case of isolated frontal sinus forming mixed bacterial colonies that occurred in the previously exposed frontal sinus. The material in the frontal sinus was macroscopically similar to sinus fungus ball. Surgical strategy followed that for sinus fungus ball. The material could not be completely removed even with an endoscopic modified Lothrop procedure (Draf type III procedure). Additional external incision enabled complete removal of the remnant infectious substance. Histological examination detected two different types of organisms as intermingled bacterial colonies. External approaches to the frontal fungus ball have recently been replaced by the endonasal approach. Our case suggests that material trapped in a pit or small crevice in a frontal sinus may not be removed intranasally.
Elastic fiber-mediated enthesis in the human middle ear Peer-reviewed

Tetsuaki Kawase, Shunichi Shibata, Yukio Katori, Aiji Ohtsuka, Gen Murakami, Mineko Fujimiya

JOURNAL OF ANATOMY　221　(4)　331-340　2012/10

DOI： 10.1111/j.1469-7580.2012.01542.x 　

ISSN： 0021-8782

eISSN： 1469-7580
Initial stage of fetal development of the pharyngotympanic tube cartilage with special reference to muscle attachments to the tube. International-journal Peer-reviewed

Katori Y, Rodríguez-Vázquez JF, Verdugo-López S, Murakami G, Kawase T, Kobayashi T

Anatomy & cell biology　45　(3)　185-192　2012/09

DOI： 10.5115/acb.2012.45.3.185 　

ISSN： 2093-3665

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Fetal development of the cartilage of the pharyngotympanic tube (PTT) is characterized by its late start. We examined semiserial histological sections of 20 human fetuses at 14-18 weeks of gestation. As controls, we also observed sections of 5 large fetuses at around 30 weeks. At and around 14 weeks, the tubal cartilage first appeared in the posterior side of the pharyngeal opening of the PTT. The levator veli palatini muscle used a mucosal fold containing the initial cartilage for its downward path to the palate. Moreover, the cartilage is a limited hard attachment for the muscle. Therefore, the PTT and its cartilage seemed to play a critical role in early development of levator veli muscle. In contrast, the cartilage developed so that it extended laterally, along a fascia-like structure that connected with the tensor tympani muscle. This muscle appeared to exert mechanical stress on the initial cartilage. The internal carotid artery was exposed to a loose tissue facing the tubal cartilage. In large fetuses, this loose tissue was occupied by an inferior extension of the temporal bone to cover the artery. This later-developing anterior wall of the carotid canal provided the final bony origin of the levator veli palatini muscle. The tubal cartilage seemed to determine the anterior and inferior margins of the canal. Consequently, the tubal cartilage development seemed to be accelerated by a surrounding muscle, and conversely, the cartilage was likely to determine the other muscular and bony structures.
Fetal developmental change in topographical relationship between the human lateral pterygoid muscle and buccal nerve

Y. Katori, M. Yamamoto, S. Asakawa, H. Maki, J. F. Rodriguez-Vazquez, G. Murakami, S. Abe

JOURNAL OF ANATOMY　220　(4)　384-395　2012/04

DOI： 10.1111/j.1469-7580.2012.01478.x 　

ISSN： 0021-8782
Transient appearance of tyrosine hydroxylase immunoreactive cells in the midline epithelial seam of the human fetal secondary palate Peer-reviewed

Yukio Katori, Shunichi Shibata, Tetsuaki Kawase, Baik Hwan Cho, Gen Murakami

Cleft Palate-Craniofacial Journal　49　(4)　414-424　2012
Publisher: American Cleft Palate Craniofacial Association
DOI： 10.1597/10-121 　

ISSN： 1545-1569 1055-6656
The anatomy of fetal peripheral lymphatic vessels in the head-and-neck region: an immunohistochemical study Peer-reviewed

Kwang Ho Cho, Jin Sung Cheong, Yeon Soo Ha, Baik Hwan Cho, Gen Murakami, Yukio Katori

Journal of Anatomy　220　(1)　102-111　2012/01

DOI： 10.1111/j.1469-7580.2011.01441.x 　

ISSN： 0021-8782
Reconsideration of the Autonomic Cranial Ganglia: An Immunohistochemical Study of Mid-Term Human Fetuses International-journal Peer-reviewed

Hiromichi Kiyokawa, Yukio Katori, Kwang Ho Cho, Gen Murakami, Tetsuaki Kawase, Baik Hwan Cho

The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology　295　(1)　141-149　2012/01

DOI： 10.1002/ar.21516 　

ISSN： 1932-8486

eISSN： 1932-8494
Creutzfeldt-Jakob Disease with Paralysis of the Unilateral Vocal Cord and Soft Palate Peer-reviewed

Jun Hasegawa, Yuuri Okumura, Etsuko Osumi, Hideaki Tago, Yukio Katori, Toshimitsu Kobayashi

The Tohoku Journal of Experimental Medicine　225　(4)　277-283　2011

DOI： 10.1620/tjem.225.277 　

ISSN： 0040-8727

eISSN： 1349-3329
New treatment for invasive fungal sinusitis: Three cases of chronic invasive fungal sinusitis treated with surgery and voriconazole Peer-reviewed

Kazuhiro Nakaya, Takeshi Oshima, Takayuki Kudo, Iori Aoyagi, Yukio Katori, Jun Ota, Hiroshi Hidaka, Kiyoshi Oda, Toshimitsu Kobayashi

Auris Nasus Larynx　37　(2)　244-249　2010/04

DOI： 10.1016/j.anl.2009.05.006 　

ISSN： 0385-8146
Developmental changes in the distribution of calretinin-immunoreactive cells in human fetal nasal epithelium Peer-reviewed

Yukio KATORI, Zhe Wu JIN, Tetsuaki KAWASE, Ki Hwan HONG, Gen MURAKAMI, Baik Hwan CHO

Okajimas Folia Anatomica Japonica　87　(1)　5-10　2010
Publisher: Department of Anatomy Keio University School of Medicine
DOI： 10.2535/ofaj.87.5 　

ISSN： 0030-154X

eISSN： 1881-1736
False positive reactivity of a substance P-antibody in the ectodermal/epithelial plug of the nose, ear, eye and perineum of the human and mouse fetuses Peer-reviewed

Hiroshi MASUMOTO, Yukio KATORI, Tetsuaki KAWASE, Baik Hwan CHO, Gen MURAKAMI, Shunichi SHIBATA, Akio MATSUBARA

Okajimas Folia Anatomica Japonica　87　(2)　33-40　2010
Publisher: Department of Anatomy Keio University School of Medicine
DOI： 10.2535/ofaj.87.33 　

ISSN： 0030-154X

eISSN： 1881-1736
Localization of aquaporins, water channel proteins, in the mouse eustachian tube Peer-reviewed

Etsu Takahashi, Toshihiko Kikuchi, Yukio Katori, Toshimitsu Kobayashi

ACTA OTO-LARYNGOLOGICA　129　67-70　2009

DOI： 10.1080/00016480902964317 　

ISSN： 0001-6489
Retropharyngeal Abscess Complicated with Torticollis: Case Report and Review of the Literature Peer-reviewed

Jun Hasegawa, Masaru Tateda, Hiroshi Hidaka, Shun Sagai, Ayako Nakanome, Katsunori Katagiri, Masahiro Seki, Yukio Katori, Toshimitsu Kobayashi

The Tohoku Journal of Experimental Medicine　213　(1)　99-104　2007

DOI： 10.1620/tjem.213.99 　

ISSN： 0040-8727

eISSN： 1349-3329
Atomic force microscopic imaging of the intracellular membrane surface of prestin-expressing Chinese hamster ovary cells Peer-reviewed

H. Wada, M. Murakoshi, K. Iida, S. Kumano, T. Gomi, K. Kimura, H. Usukura, M. Sugawara, S. Kakehata, K. Ikeda, Y. Katori, T. Kobayashi

Auditory Mechanisms: Processes and Models　26-33　2006
Imaging and mechanical properties of guinea pig outer hair cells studied by atomic force microscopy

H. Wada, M. Sugawara, K. Kimura, Y. Ishida, T. Gomi, M. Murakoshi, Y. Katori, S. Kakehata, K. Ikeda, T. Kobayashi

Biomechanics at Micro- and Nanoscale Levels: Volume I　3-15　2005/01/01
Publisher: World Scientific Publishing Co.
DOI： 10.1142/9789812569301_0001 　
Imaging of the cortical cytoskeleton of guinea pig outer hair cells using atomic force microscopy Peer-reviewed

H Wada, K Kimura, T Gomi, M Sugawara, Y Katori, S Kakehata, K Ikeda, T Kobayashi

HEARING RESEARCH　187　(1-2)　51-62　2004/01

DOI： 10.1016/S0378-5955(03)00334-4 　

ISSN： 0378-5955
Transgenic expression of a dominant-negative connexin26 causes degeneration of the organ of Corti and non-syndromic deafness. International-journal Peer-reviewed

Takayuki Kudo, Shigeo Kure, Katsuhisa Ikeda, An-Ping Xia, Yukio Katori, Masaaki Suzuki, Kanako Kojima, Akiko Ichinohe, Yoichi Suzuki, Yoko Aoki, Toshimitsu Kobayashi, Yoichi Matsubara

Human molecular genetics　12　(9)　995-1004　2003/05/01

DOI： 10.1093/hmg/ddg116 　

ISSN： 0964-6906
Defibrinogenation therapy for idiopathic sudden sensorineural hearing loss in comparison with high-dose steroid therapy. International-journal Peer-reviewed

Hideaki Suzuki, Masayuki Furukawa, Masaki Kumagai, Etsu Takahashi, Kazuto Matsuura, Yukio Katori, Akira Shimomura, Toshimitsu Kobayashi

Acta oto-laryngologica　123　(1)　46-50　2003/01

DOI： 10.1080/0036554021000028082 　

ISSN： 0001-6489
Expression of the Sox10 gene during mouse inner ear development Peer-reviewed

K Watanabe, K Takeda, Y Katori, K Ikeda, T Oshima, K Yasumoto, H Saito, T Takasaka, S Shibahara

MOLECULAR BRAIN RESEARCH　84　(1-2)　141-145　2000/12

DOI： 10.1016/S0169-328X(00)00236-9 　

ISSN： 0169-328X
Expression of connexin 31 in the developing mouse cochlea Peer-reviewed

AP Xia, K Ikeda, Y Katori, T Oshima, T Kikuchi, T Takasaka

NEUROREPORT　11　(11)　2449-2453　2000/08

ISSN： 0959-4965
Expression of connexin 26 and Na,K-ATPase in the developing mouse cochlear lateral wall: functional implications Peer-reviewed

AP Xia, T Kikuchi, K Hozawa, Y Katori, T Takasaka

BRAIN RESEARCH　846　(1)　106-111　1999/10

DOI： 10.1016/S0006-8993(99)01996-4 　

ISSN： 0006-8993
Density of motility-related charge in the outer hair cell of the guinea pig is inversely related to best frequency Peer-reviewed

J Santos-Sacchi, S Kakehata, T Kikuchi, Y Katori, T Takasaka

NEUROSCIENCE LETTERS　256　(3)　155-158　1998/11

DOI： 10.1016/S0304-3940(98)00788-5 　

ISSN： 0304-3940
Acute effects of combined administration of kanamycin and furosemide on the stria vascularis studied by distortion product otoacoustic emission and transmission electron microscopy Peer-reviewed

SA Alam, K Ikeda, T Kawase, T Kikuchi, Y Katori, K Watanabe, T Takasaka

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　186　(2)　79-86　1998/10

DOI： 10.1620/tjem.186.79 　

ISSN： 0040-8727

eISSN： 1349-3329
The usefulness of computed tomography in the diagnosis of impacted fish bones in the oesophagus Peer-reviewed

K Watanabe, T Kikuchi, Y Katori, H Fujiwara, R Sugita, T Takasaka, S Hashimoto

JOURNAL OF LARYNGOLOGY AND OTOLOGY　112　(4)　360-364　1998/04

ISSN： 0022-2151
Carbohydrate composition of stereociliary glycocalyx of the utricle of guinea pig inner ear Peer-reviewed

Hideaki Suzuki, Yukio Katori, Tomonori Takasaka

Acta Oto-Laryngologica　116　(1)　12-16　1996

DOI： 10.3109/00016489609137706 　

ISSN： 0001-6489
Isolation of acini from nasal glands of the guinea‐pig Peer-reviewed

H. SUNOSE, W. ZHANG, M. ISHIGAKI, Y. KATORI, M. SUZUKI, K. IKEDA, T. TAKASAKA, Y. SAITO, A. NISHIYAMA

Acta Physiologica Scandinavica　151　(3)　377-384　1994/07
Publisher: Wiley
DOI： 10.1111/j.1748-1716.1994.tb09757.x 　

ISSN： 0001-6772

eISSN： 1365-201X
Fine Structure of the Lamina Basilaris of Guinea Pig Cochlea Peer-reviewed

Yukio Katori, Koji Hozawa, Toshihiko Kikuchi, Akira Tonosaki, Tomonori Takasaka

Acta Oto-Laryngologica　113　(6)　715-719　1993/01
Publisher: Informa UK Limited
DOI： 10.3109/00016489309135890 　

ISSN： 0001-6489

eISSN： 1651-2251
Microtubules of Guinea Pig Cochlear Epithelial Cells Peer-reviewed

Toshihiko Kikuchi, Tomonori Takasaka, Akira Tonosaki, Yukio Katori, Hideichi Shinkawa

Acta Oto-Laryngologica　111　(2)　286-290　1991/01
Publisher: Informa UK Limited
DOI： 10.3109/00016489109137389 　

ISSN： 0001-6489

eISSN： 1651-2251

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Misc. 716

誤嚥防止手術が慢性誤嚥による気管軟化症の改善に寄与したと考えられた一例

太田淳, 平野愛, 香取幸夫

日本喉頭科学会総会学術講演会プログラムおよび予稿集　36th　2024
誤嚥防止手術-喉頭中央部切除術を中心に-

平野愛, 太田淳, 加藤健吾, 香取幸夫

日本耳鼻咽喉科頭頚部外科学会会報　127　(4)　2024

ISSN： 2436-5793
聴力検査アプリケーションソフトの有用性に関する検討

佐藤剛史, 加藤大雅, 久岡巧麻, 太田淳, 本藏陽平, 香取幸夫, 香取幸夫

耳鼻咽喉科臨床補冊　(166)　2024

ISSN： 0912-1870
嚥下治療センター受診患者の不安と嚥下機能の関係

久岡巧麻, 鈴木淳, 太田淳, 平野愛, 香取幸夫

日本嚥下医学会抄録(Web)　47th　2024
入院栄養管理体制加算算定後の効果の検証

玉山咲紀, 田中千尋, 佐々木まなみ, 佐々木捺海, 古積杏花, 布田美貴子, 香取幸夫

日本病態栄養学会誌　27　(Suppl.)　S-75　2024/01
Publisher: (一社)日本病態栄養学会
ISSN： 1345-8167
病棟スタッフへのアンケート調査結果から見る入院栄養管理体制加算算定後の効果と課題の検証

田中千尋, 玉山咲紀, 佐々木まなみ, 佐々木捺海, 古積杏花, 布田美貴子, 香取幸夫

日本病態栄養学会誌　27　(Suppl.)　S-75　2024/01
Publisher: (一社)日本病態栄養学会
ISSN： 1345-8167
医工産学連携による「医師の働き方改革」の実証実験自然言語処理による経過サマリ作成支援を中心に

石井亮, 宇野裕, 辻川剛範, 中川敦寛, 久保雅洋, 香取幸夫

日本内視鏡外科学会雑誌　28　(7)　1622-1622　2023/12
Publisher: (一社)日本内視鏡外科学会
ISSN： 1344-6703

eISSN： 2186-6643
本邦全域におけるインフルエンザ菌の薬剤耐性に関する検討

北谷栞, 香取幸夫

東北医学雑誌　135　(2)　78-78　2023/12
Publisher: 東北医学会
ISSN： 0040-8700
両側同時人工内耳埋め込み術の際に両正円窓が骨性閉鎖していた1症例

織田潔, 香取幸夫, 小林俊光

日本耳科学会総会・学術講演会抄録集　33回　136-136　2023/11
Publisher: (一社)日本耳科学会
一酸化炭素中毒による急性感音難聴の1例

遠藤拓弥, 鈴木淳, 池田怜吉, 香取幸夫

日本耳科学会総会・学術講演会抄録集　33回　419-419　2023/11
Publisher: (一社)日本耳科学会
多職種・多部門が連携した誤嚥・窒息事故防止のための取り組み

田畑雅央, 平野愛, 太田淳, 白石成, 土肥千秋, 香取幸夫

医療の質・安全学会誌　18　(Suppl.)　364-364　2023/11
Publisher: (一社)医療の質・安全学会
ISSN： 1881-3658

eISSN： 1882-3254
嚥下障害の治療とこれから

香取幸夫

日本呼吸ケア・リハビリテーション学会誌　33　(Suppl.)　73s-73s　2023/11
Publisher: (一社)日本呼吸ケア・リハビリテーション学会
ISSN： 1881-7319

eISSN： 2189-4760
良性耳下腺腫瘍におけるペリオスチンの発現

舘田豊, 鈴木貴博, 佐藤輝幸, 香取幸夫, 太田伸男

日本唾液腺学会誌　63　23-24　2023/11
Publisher: 日本唾液腺学会
ISSN： 0916-1104

eISSN： 2759-0003
治療経過サマリ作成支援のための診察記事からの医療情報抽出

宇野裕, 石井亮, 柴田大作, 辻川剛範, 中川敦寛, 久保雅洋, 香取幸夫

医療情報学連合大会論文集　43回　597-600　2023/11
Publisher: (一社)日本医療情報学会
ISSN： 1347-8508

eISSN： 2433-698X
骨格筋におけるシステイニルtRNA合成酵素1(CARS1)によるポリスルフィド産生の生理学的機能

草野佑典, 村上昌平, 守田匡伸, 井田智章, 香取幸夫, 赤池孝章, 本橋ほづみ

日本生化学会大会プログラム・講演要旨集　96回　[1T04a-237)]　2023/10
Publisher: (公社)日本生化学会
超音波Bモード画像のテンプレートマッチングによる嚥下運動解析法の検討

川上紗弥香, 澤田朱里, 太田淳, 石井琢郎, 香取幸夫, 西條芳文

電子情報通信学会技術研究報告(超音波)　123　(214)　19-23　2023/10
Publisher: (一社)電子情報通信学会
ISSN： 0913-5685

eISSN： 2432-6380
反回神経麻痺ゼロを目指したベストアプローチ声は良くなります片側性反回神経麻痺患者の音声改善手術

香取幸夫, 平野愛, 佐藤剛史

日本胸部外科学会定期学術集会　76回　CDPD1-1　2023/10
Publisher: (一社)日本胸部外科学会
若年者における音楽聴取習慣と聴覚機能に関する検討

石田智靖, 鈴木淳, 大石哲也, 佐藤剛史, 本蔵陽平, 池田怜吉, 香取幸夫

Audiology Japan　66　(5)　460-460　2023/09
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
聴性誘発脳磁界N100m反応からみた対側音刺激に関連する視覚情報提示の影響の検討

高井俊輔, 川瀬哲明, 白倉真之, 鈴木淳, 中里信和, 香取幸夫

Audiology Japan　66　(5)　480-480　2023/09
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
嚥下医学ベーシックサイエンス食道運動を支配する腸管神経叢について

平野愛, 香取幸夫

嚥下医学　12　(2)　172-176　2023/09
Publisher: 日本嚥下医学会
ISSN： 2186-3199
聴性誘発脳磁界N100m反応からみた対側音刺激に関連する視覚情報提示の影響の検討

高井俊輔, 川瀬哲明, 白倉真之, 鈴木淳, 中里信和, 香取幸夫

Audiology Japan　66　(5)　480-480　2023/09
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
若年者における音楽聴取習慣と聴覚機能に関する検討

石田智靖, 鈴木淳, 大石哲也, 佐藤剛史, 本蔵陽平, 池田怜吉, 香取幸夫

Audiology Japan　66　(5)　460-460　2023/09
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
サルモネラ人工弁感染性心内膜炎に関するレビュー

北谷栞, 片平晋太郎, 馬場啓聡, 齋木佳克, 香取幸夫, 徳田浩一, 金森肇

日本臨床腸内微生物学会総会・学術集会プログラム・抄録集　26回　26-26　2023/08
Publisher: 日本臨床腸内微生物学会
先天性真珠腫および後天性真珠腫におけるペリオスチンの発現の検討

北谷栞, 太田伸男, 鈴木淳, 池田怜吉, 大島英敏, 野村有理, 草野佑典, 佐藤輝幸, 川瀬哲明, 香取幸夫

日本耳鼻咽喉科頭頸部外科学会会報　126　(4)　585-585　2023/04
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 2436-5793

eISSN： 2436-5866
声帯ポリープにおけるD-アスパラギン酸およびペリオスチンの発現の検討

舘田豊, 池田怜吉, 角田梨紗子, 小川武則, 香取幸夫, 太田伸男

日本耳鼻咽喉科頭頸部外科学会会報　126　(4)　591-591　2023/04
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 2436-5793

eISSN： 2436-5866
好酸球性中耳炎に合併した中耳コレステリン肉芽腫に対して大口径鼓膜換気チューブが奏功した一例

石垣賢人, 吉田拓矢, 小泉祥太郎, 香取幸夫, 鈴木淳, 小林祐太, 白倉真之, 池田怜吉

日本耳鼻咽喉科頭頸部外科学会会報　126　(4)　680-680　2023/04
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 2436-5793

eISSN： 2436-5866
痙攣性発声障害診断基準および重症度分類に則したボツリヌストキシン注入術の治療効果の検討

波多野雅輝, 堀江玲央, 長谷川智弘, 廣崎真柚, 駒澤大吾, 中村一博, 香取幸夫, 渡邊雄介

日本耳鼻咽喉科頭頸部外科学会会報　126　(4)　670-670　2023/04
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 2436-5793

eISSN： 2436-5866
最近12年間に東北大学病院耳鼻咽喉・頭頸部外科で検出されたMRSAの臨床的検討

角田梨紗子, 金森肇, 北谷栞, 香取幸夫

日本耳鼻咽喉科免疫アレルギー感染症学会抄録集　3回　193-193　2023/03
Publisher: 日本耳鼻咽喉科免疫アレルギー感染症学会
eISSN： 2435-7987
当院嚥下センターを受診した封入体筋炎の症例

久岡巧麻, 平野愛, 太田淳, 香取幸夫

日本嚥下医学会抄録(Web)　46th　2023
狭小腔手術で微細操作が可能なスティックアームを備えた耳科内視鏡の開発

山内大輔, 本藏陽平, 石井亮, 太田淳, 鈴木淳, 香取幸夫

日本耳鼻咽喉科頭頚部外科学会会報　126　(4)　2023

ISSN： 2436-5793
Deglutition Analysis Method by Template Matching of Ultrasound B-mode Images

川上紗弥香, 澤田朱里, 太田淳, 石井琢郎, 香取幸夫, 西條芳文

電子情報通信学会技術研究報告(Web)　123　(214(US2023 37-42))　2023

ISSN： 2432-6380
A case of anti-NXP-2 antibody-positive dermatomyositis with multidisciplinary information sharing of dysphagia using tongue pressure and Hyodo score

太田淳, 平野愛, 久岡巧麻, 森山さや香, 香取幸夫

日本摂食嚥下リハビリテーション学会学術大会抄録集(Web)　29th　2023
Effectiveness of interprofessional work for severe dysphagia after thyroid cancer surgery: A case report

久岡巧麻, 平野愛, 太田淳, 香取幸夫

日本摂食嚥下リハビリテーション学会学術大会抄録集(Web)　29th　2023
Effect of assigning registered dietitians to the otolaryngology-head and neck surgery ward

玉山咲紀, 石井亮, 布田美貴子, 平野愛, 太田淳, 香取幸夫, 香取幸夫

日本摂食嚥下リハビリテーション学会学術大会抄録集(Web)　29th　2023
NST活動の進化-ベッドサイドからの報告- 東北大学NST栄養支援ステーションの取り組み

伊関雅裕, 石田晶玄, 小澤洋平, 遠藤佳子, 鈴木千恵, 吉中千佳, 佐藤裕子, 土肥千秋, 丹田奈緒子, 西川祐未, 田中千尋, 佐々木まなみ, 武田みゆき, 布田美貴子, 香取幸夫

外科と代謝・栄養　57　(3)　102-102　2023
Publisher: 日本外科代謝栄養学会
ISSN： 0389-5564

eISSN： 2187-5154
表皮水疱症の下腿潰瘍症例にNST介入した一症例

武田みゆき, 佐々木まなみ, 田口雄也, 西川祐未, 伊関雅裕, 石田晶玄, 布田美貴子, 香取幸夫

学会誌JSPEN　5　(Suppl.2)　35-35　2023
Publisher: (一社)日本栄養治療学会
eISSN： 2434-4966
16Sr RNA遺伝子解析を用いた感染性腹部大動脈瘤17例の原因菌同定とHelicobacter cinaediに関する遺伝学的検討

角田梨紗子, 金森肇, 清水拓也, 猪股真也, 藤川祐子, 八田益充, 青柳哲史, 矢野寿一, 香取幸夫

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　72nd-70th　(1)　126-126　2023
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
在宅中心静脈栄養中に鉄過剰を認めた腸管不全の1例

吉中千佳, 前嶋隆弘, 前川正充, 布田美貴子, 武田みゆき, 佐々木まなみ, 田中千尋, 香取幸夫, 和田基, 工藤博典, 中村恵美, 櫻井毅, 石田晶玄, 渡辺和宏

日本臨床栄養代謝学会学術集会(Web)　38th　2023
栄養サポートチーム体制の変遷と今後のチーム運営の在り方の検討

田中千尋, 佐々木まなみ, 布田美貴子, 伊関雅裕, 石田晶玄, 香取幸夫

日本病態栄養学会誌　26　(Suppl.)　S-9　2023/01
Publisher: (一社)日本病態栄養学会
ISSN： 1345-8167
高度肥満合併のS状結腸癌膀胱浸潤患者に対し術前減量のための栄養介入を行った一例

西川祐未, 唐澤秀明, 伊関雅裕, 石田晶玄, 布田美貴子, 香取幸夫

日本病態栄養学会誌　26　(Suppl.)　S-44　2023/01
Publisher: (一社)日本病態栄養学会
ISSN： 1345-8167
東北大学NST栄養支援ステーションの取り組み

伊関雅裕, 石田晶玄, 小澤洋平, 遠藤佳子, 鈴木千恵, 吉中千佳, 佐藤裕子, 土肥千秋, 丹田奈緒子, 西川祐未, 田中千尋, 佐々木まなみ, 武田みゆき, 布田美貴子, 香取幸夫

学会誌JSPEN　4　(Suppl.2)　31-31　2022/12
Publisher: (一社)日本臨床栄養代謝学会
eISSN： 2434-4966
【窒息ゼロを目指す】実践報告東北大学病院(宮城県仙台市青葉区)誤嚥・窒息予防のための多職種・多部門の連携

田畑雅央, 平野愛, 太田淳, 白石成, 土肥千秋, 香取幸夫

患者安全推進ジャーナル　(70)　18-23　2022/12
Publisher: (公財)日本医療機能評価機構
自己記入式CGAによる頭頸部がん患者の高齢に関連するアウトカムの予測

石井亮, 大越明, 中山勇樹, 東賢二郎, 中目亜矢子, 香取幸夫

日本癌治療学会学術集会抄録集　60回　P60-3　2022/10
Publisher: (一社)日本癌治療学会
下顎正中離断・経口蓋アプローチ法と経鼻内視鏡を併用した上咽頭悪性腫瘍の切除

佐藤悠歩, 東賢二郎, 石井亮, 中山勇樹, 中目亜矢子, 大越明, 香取幸夫

頭頸部外科　32　(2)　185-190　2022/10
Publisher: (NPO)日本頭頸部外科学会
ISSN： 1349-581X

eISSN： 1884-474X
内視鏡下耳科手術を施行したmalleus barの2症例とstapes barの1症例について

安齋菜々子, 山内大輔, 池田怜吉, 安達美佳, 齋藤雄太郎, 大石哲也, 香取幸夫

日本耳科学会総会・学術講演会抄録集　32回　150-150　2022/10
Publisher: (一社)日本耳科学会
NMRメタボローム解析を用いた加齢性難聴の病態に関わる代謝物の探索

鈴木淳, 池田怜吉, 川瀬哲明, 香取幸夫

日本耳科学会総会・学術講演会抄録集　32回　176-176　2022/10
Publisher: (一社)日本耳科学会
脂肪酸結合タンパク質7型(Fabp7)の欠損が騒音曝露後の聴覚機能に与える影響

鈴木淳, 池田怜吉, 本蔵陽平, 川瀬哲明, 香取幸夫

Audiology Japan　65　(5)　316-316　2022/09
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
STRC-CATSPER2遺伝子2 copy lossによる難聴の3症例

織田潔, 香取幸夫, 宇佐美真一, 西尾信哉

Audiology Japan　65　(5)　407-407　2022/09
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
東北メディカル・メガバンクの大規模コホートデータを用いた加齢性難聴の疫学研究

渡耒剛右, 鈴木淳, 池田怜吉, 川瀬哲明, 香取幸夫

Audiology Japan　65　(5)　412-412　2022/09
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
早期診断・早期療育を行うことができたHDR症候群の一例

高井俊輔, 安達美佳, 白倉真之, 山内大輔, 川瀬哲明, 香取幸夫

Audiology Japan　65　(5)　463-463　2022/09
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
東北大学病院耳鼻咽喉・頭頸部外科における新型コロナウイルススクリーニングPCR検査の現状調査

角田梨紗子, 金森肇, 徳田浩一, 北谷栞, 香取幸夫

日本耳鼻咽喉科免疫アレルギー感染症学会誌　2　(3)　109-114　2022/09
Publisher: 日本耳鼻咽喉科免疫アレルギー感染症学会
eISSN： 2435-7952
胃食道逆流が証明された、睡眠関連喉頭痙攣の1例

安達美佳, 石川智彦, 香取幸夫

口腔・咽頭科　35　(3)　248-248　2022/08
Publisher: 日本口腔・咽頭科学会
ISSN： 0917-5105

eISSN： 1884-4316
【視覚誘発電位・磁界、聴覚誘発電位・磁界】聴性誘発脳磁界(N1m) 音楽による影響と選択的注意

白倉真之, 川瀬哲明, 菅野彰剛, 太田淳, 中里信和, 川島隆太, 香取幸夫

臨床神経生理学　50　(4)　138-142　2022/08
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
【手術に役立つ臨床解剖】嚥下障害に対する手術

香取幸夫

耳鼻咽喉科　2　(1)　80-85　2022/07
Publisher: (有)科学評論社
ISSN： 2436-5726
リハビリテーションが有効であった、食道閉鎖症再手術後に誤嚥性肺炎を反復した嚥下障害の1例

安達美佳, 香取幸夫

小児耳鼻咽喉科　43　(2)　237-237　2022/06
Publisher: 日本小児耳鼻咽喉科学会
ISSN： 0919-5858

eISSN： 2186-5957
頭頸部外来における自己記入式CGAの導入

石井亮, 大越明, 東賢二郎, 中目亜矢子, 中山勇樹, 香取幸夫

頭頸部癌　48　(2)　189-189　2022/05
Publisher: (一社)日本頭頸部癌学会
ISSN： 1349-5747

eISSN： 1881-8382
高齢者総合機能評価に適した聴覚スクリーニング測定用アプリケーションの開発

冨田尚希, 佐藤剛史, 本蔵陽平, 鈴木淳, 香取幸夫, 瀧靖之

日本老年医学会雑誌　59　(Suppl.)　116-116　2022/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
神経筋疾患を模した運動モデルを用いた嚥下物の挙動の検討

太田淳, 川瀬哲明, 香取幸夫

耳鼻咽喉科ニューロサイエンス　35　82-84　2022/05
Publisher: 耳鼻咽喉科ニューロサイエンス研究会
筋性耳鳴4症例の検討

織田潔, 小泉祥太郎, 日高浩史, 小林俊光, 大山健二, 香取幸夫

Otology Japan　32　(2)　227-233　2022/05
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
頭頸部外来における自己記入式CGAの導入

石井亮, 大越明, 東賢二郎, 中目亜矢子, 中山勇樹, 香取幸夫

頭頸部癌　48　(2)　189-189　2022/05
Publisher: (一社)日本頭頸部癌学会
ISSN： 1349-5747

eISSN： 1881-8382
スギ花粉症に対する舌下免疫療法の小児と成人における比較調査

佐藤輝幸, 太田伸男, 湯田厚司, 小川由起子, 鈴木貴博, 東海林史, 野口直哉, 鈴木直弘, 草刈千賀志, 田畑邦次, 郭冠宏, 沖津尚弘, 長谷川純, 柴原義博, 中林成一郎, 稲村直樹, 大井聖幸, 高梨芳崇, 鈴木淳, 菅原充, 野村和弘, 香取幸夫, 岡本美孝

日本耳鼻咽喉科頭頸部外科学会会報　125　(5)　876-883　2022/05
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 2436-5793

eISSN： 2436-5866
嚥下性肺炎の重症化予防における、転写因子Nrf2の機能の解析

橋本光, 岡崎達馬, 本蔵陽平, 香取幸夫

日本耳鼻咽喉科頭頸部外科学会会報　125　(4)　725-725　2022/04
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 2436-5793

eISSN： 2436-5866
一側迷走神経麻痺が嚥下機能に与える影響と誤嚥性肺炎の重症化に及ぼす影響について

辰島大介, 水足邦雄, 栗岡隆臣, 小柴康利, 高橋ひより, 橋本光, 鈴木淳, 池田怜吉, 香取幸夫, 塩谷彰浩

日本耳鼻咽喉科頭頸部外科学会会報　125　(4)　726-726　2022/04
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 2436-5793

eISSN： 2436-5866
頭頸部再建手術における高齢者機能評価スクリーニングツール(G8)の合併症予測に対する有用性

中山勇樹, 大越明, 石井亮, 中目亜矢子, 東賢二郎, 香取幸夫

日本気管食道科学会会報　73　(2)　s22-s22　2022/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
甲状腺の取扱いに配慮した食道癌集学的治療後のハイリスク下咽頭喉頭摘出術の一例(気管壊死症例との比較

石井亮, 大越明, 中山勇樹, 東賢二郎, 中目亜矢子, 岡本宏史, 谷山裕亮, 香取幸夫

日本気管食道科学会会報　73　(2)　s42-s42　2022/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
頭頸部癌治療が副鼻腔粘膜に与える影響について

鈴木淳, 逸見朋隆, 石井亮, 池田怜吉, 小林祐太, 生島寛享, 野村和弘, 菅原充, 大越明, 香取幸夫

日本耳鼻咽喉科頭頸部外科学会会報　125　(4)　724-724　2022/04
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 2436-5793

eISSN： 2436-5866
本邦におけるHPV関連中咽頭癌予防に向けたHPV16 Virus Variant調査とワクチン効果予測

吉田拓矢, 中目亜矢子, 大越明, 東健次郎, 石井亮, 石川智彦, 古川徹, 小川武則, 香取幸夫

日本耳鼻咽喉科頭頸部外科学会会報　125　(4)　749-749　2022/04
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 2436-5793

eISSN： 2436-5866
頭頸部癌治療が副鼻腔粘膜に与える影響について

鈴木淳, 逸見朋隆, 石井亮, 池田怜吉, 小林祐太, 生島寛享, 野村和弘, 菅原充, 大越明, 香取幸夫

日本耳鼻咽喉科頭頸部外科学会会報　125　(4)　724-724　2022/04
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 2436-5793

eISSN： 2436-5866
一側迷走神経麻痺が嚥下機能に与える影響と誤嚥性肺炎の重症化に及ぼす影響について

辰島大介, 水足邦雄, 栗岡隆臣, 小柴康利, 高橋ひより, 橋本光, 鈴木淳, 池田怜吉, 香取幸夫, 塩谷彰浩

日本耳鼻咽喉科頭頸部外科学会会報　125　(4)　726-726　2022/04
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 2436-5793

eISSN： 2436-5866
Ndufs4の欠失が音響曝露後の聴覚に及ぼす影響

逸見朋隆, 鈴木淳, 本藏陽平, 池田怜吉, 橋本研, 川瀬哲明, 香取幸夫

日本耳鼻咽喉科頭頸部外科学会会報　125　(4)　730-730　2022/04
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 2436-5793

eISSN： 2436-5866
先天性真珠腫および後天性真珠腫におけるアスパラギン酸の発現の検討

北谷栞, 太田伸男, 鈴木淳, 池田怜吉, 大島英敏, 野村有理, 草野佑典, 川瀬哲明, 香取幸夫

日本耳鼻咽喉科頭頸部外科学会会報　125　(4)　731-731　2022/04
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 2436-5793

eISSN： 2436-5866
当科で経験した小児気管・気管支異物の過去36年の推移について

高橋ひより, 鈴木淳, 池田怜吉, 太田淳, 平野愛, 大石哲也, 香取幸夫

日本耳鼻咽喉科頭頸部外科学会会報　125　(4)　771-771　2022/04
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 2436-5793

eISSN： 2436-5866
嚥下障害に対するチーム医療急性期病院(医育機関)における活動

香取幸夫, 太田淳, 平野愛

日本気管食道科学会会報　73　(2)　129-129　2022/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
喉頭枠組み手術を行う片側性声帯麻痺患者の発話検査

香取幸夫, 佐藤剛史, 平野愛, 本藏陽平, 渡邊健一

日本気管食道科学会会報　73　(2)　s10-s10　2022/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
重症神経筋疾患患者を模した嚥下障害モデルにおける数値流体力学シミュレーション

太田淳, 石田駿一, 今井陽介, 川瀬哲明, 香取幸夫

日本気管食道科学会会報　73　(2)　s19-s19　2022/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
小動物用嚥下造影装置を用いた亜鉛欠乏モデルマウスの嚥下機能解析

小柴康利, 池田怜吉, 鈴木淳, 香取幸夫

日本気管食道科学会会報　73　(2)　s20-s20　2022/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
筋ジストロフィー患者の病型による嚥下内視鏡検査、舌圧測定結果と肺炎発症率の違いについて

平野愛, 神林友紀, 池田怜吉, 太田淳, 香取幸夫

日本気管食道科学会会報　73　(2)　s21-s21　2022/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
最近14年間に東北大学病院耳鼻咽喉・頭頸部外科において検出されたインフルエンザ菌の薬剤感受性の現状

北谷栞, 角田梨紗子, 香取幸夫

日本耳鼻咽喉科免疫アレルギー感染症学会抄録集　2回　170-170　2022/03
Publisher: 日本耳鼻咽喉科免疫アレルギー感染症学会
eISSN： 2435-7987
スギ花粉症に対する舌下免疫療法の小児と成人における比較調査

佐藤輝幸, 太田伸男, 湯田厚司, 東海林史, 野口直哉, 鈴木直弘, 草刈千賀志, 柴原義博, 稲村直樹, 香取幸夫, 岡本美孝

日本耳鼻咽喉科免疫アレルギー感染症学会抄録集　2回　82-82　2022/03
Publisher: 日本耳鼻咽喉科免疫アレルギー感染症学会
eISSN： 2435-7987
最近14年間に東北大学病院耳鼻咽喉・頭頸部外科において検出されたインフルエンザ菌の薬剤感受性の現状

北谷栞, 角田梨紗子, 香取幸夫

日本耳鼻咽喉科免疫アレルギー感染症学会抄録集　2回　170-170　2022/03
Publisher: 日本耳鼻咽喉科免疫アレルギー感染症学会
eISSN： 2435-7987
緊急手術を要した下咽頭異物(ネーザルスプリント)の1例

北谷栞, 太田伸男, 齋藤雄太郎, 野口直哉, 山崎宗治, 鈴木貴博, 東海林史, 香取幸夫

口腔・咽頭科　35　(1)　21-24　2022/03
Publisher: 日本口腔・咽頭科学会
ISSN： 0917-5105

eISSN： 1884-4316
ANL Secondary Publication 視覚聴覚併用課題を用いた在宅での聴覚訓練実現可能性と予備的検討

佐藤剛史, 藪下友子, 坂本修一, 香取幸夫, 川瀬哲明

日本耳鼻咽喉科頭頸部外科学会会報　125　(3)　321-322　2022/03
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 2436-5793

eISSN： 2436-5866
3D-VR画像による評価と経鼻中隔アプローチによる鼻内視鏡下摘出術が有用であった上咽頭異物の1例

中山勇樹, 鈴木淳, 太田淳, 平野愛, 高橋ひより, 中角美穂, 大越明, 香取幸夫

日本耳鼻咽喉科頭頚部外科学会会報　125　(4)　2022

ISSN： 2436-5793
多系統萎縮症における患者背景,嚥下スクリーニング検査の結果と嚥下障害の重症度に関する検討

平野愛, 平野愛, 太田淳, 香取幸夫

日本喉頭科学会総会学術講演会プログラムおよび予稿集　34th　2022
Detection of airway invasion by Videofluorographic Swallowing Study using deep-learning

金岡拓馬, 石田駿一, 太田淳, 川瀬哲明, 香取幸夫, 今井陽介

日本機械学会バイオフロンティア講演会講演論文集(CD-ROM)　33rd　2022

ISSN： 1348-2939
聴性誘発脳磁界 (N1m) -音楽による影響と選択的注意-

白倉真之, 川瀬哲明, 川瀬哲明, 菅野彰剛, 菅野彰剛, 太田淳, 中里信和, 中里信和, 川島隆太, 香取幸夫

臨床神経生理学(Web)　50　(4)　2022

ISSN： 2188-031X
つながる:咽頭から食道へ-UES/食道の生理・評価・応用- 咽頭と食道の関連嚥下に関わる「構造の連続性」と「運動の相違」

香取幸夫, 平野愛

日本摂食・嚥下リハビリテーション学会雑誌　25　(3)　S32-S32　2021/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
小動物用嚥下造影装置を用いた亜鉛欠乏モデルマウスの嚥下機能解析

小柴康利, 戸塚大幾, 平野愛, 香取幸夫

日本摂食・嚥下リハビリテーション学会雑誌　25　(3)　S84-S84　2021/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
嚥下内視鏡検査による筋ジストロフィー患者の肺炎発症のリスク評価

神林友紀, 平野愛, 太田淳, 大村悠, 由利博美, 高橋俊明, 武田篤, 香取幸夫

日本摂食・嚥下リハビリテーション学会雑誌　25　(3)　S105-S105　2021/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
【耳鼻咽喉科疾患とバリアフリー】音声障害とバリアフリー

佐藤剛史, 香取幸夫

ENTONI　(265)　58-64　2021/12
Publisher: (株)全日本病院出版会
ISSN： 1346-2067
親電子性ストレス曝露履歴モニタリングマウスの樹立

北村大志, 大石哲也, 村上昌平, 香取幸夫, 本橋ほづみ

日本生化学会大会プログラム・講演要旨集　94回　[P-06)]　2021/11
Publisher: (公社)日本生化学会
聴性誘発脳磁界N100m反応に認められる音楽による対側耳マスキング効果

白倉真之, 川瀬哲明, 菅野彰剛, 太田淳, 中里信和, 川島隆太, 香取幸夫

臨床神経生理学　49　(5)　440-440　2021/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
高齢者機能評価スクリーニングを用いた頭頸部癌化学療法の有害事象予測

石井亮, 中目亜矢子, 高橋昌宏, 大越明, 香取幸夫

日本癌治療学会学術集会抄録集　59回　O40-4　2021/10
Publisher: (一社)日本癌治療学会
高齢者機能評価スクリーニングを用いた頭頸部癌化学療法の有害事象予測

石井亮, 中目亜矢子, 高橋昌宏, 大越明, 香取幸夫

日本癌治療学会学術集会抄録集　59回　O40-4　2021/10
Publisher: (一社)日本癌治療学会
聴性誘発脳磁界N100m反応に認められる音楽による対側耳マスキング効果

白倉真之, 川瀬哲明, 菅野彰剛, 太田淳, 中里信和, 川島隆太, 香取幸夫

臨床神経生理学　49　(5)　440-440　2021/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
片側性声帯麻痺患者の喉頭枠組み術前後での発話音声機能を評価するための音読課題と評価指標に関する検討

佐藤剛史, 苅安誠, 渡邊健一, 本蔵陽平, 平野愛, 鹿島和孝, 香取幸夫

音声言語医学　62　(4)　305-313　2021/10
Publisher: 日本音声言語医学会
ISSN： 0030-2813

eISSN： 1884-3646
良聴耳の半規管手術水中内視鏡下手術の経験

山内大輔, 本藏陽平, 橋本研, 川村善宣, 橋本光, 池田怜吉, 神林友紀, 大石哲也, 小林俊光, 大島英敏, 草野佑典, 川瀬哲明, 香取幸夫

日本耳科学会総会・学術講演会抄録集　31回　177-177　2021/10
Publisher: (一社)日本耳科学会
耳管ピン挿入術後の耳管機能

草野佑典, 川村善宣, 池田怜吉, 大島英敏, 菊地俊晶, 香取幸夫, 小林俊光

日本耳科学会総会・学術講演会抄録集　31回　205-205　2021/10
Publisher: (一社)日本耳科学会
眼咽頭型筋ジストロフィー(OPMD)患者における耳管開放症の検討

池田怜吉, 石垣賢人, 鈴木淳, 川瀬哲明, 香取幸夫

日本耳科学会総会・学術講演会抄録集　31回　210-210　2021/10
Publisher: (一社)日本耳科学会
スギ花粉症に対する舌下免疫療法に関する小児と大人の比較検討

太田伸男, 湯田厚司, 鈴木祐輔, 稲村直樹, 東海林史, 山崎宗治, 柴原義博, 佐藤輝幸, 野口直哉, 香取幸夫, 岡本美孝

日本鼻科学会会誌　60　(3)　309-309　2021/09
Publisher: (一社)日本鼻科学会
ISSN： 0910-9153

eISSN： 1883-7077
片側性声帯麻痺患者に対しての発話評価の意義文章音読課題による休止区間の頻度と時間的解析での術前後比較

佐藤剛史, 苅安誠, 本蔵陽平, 平野愛, 鹿島和孝, 渡邊健一, 香取幸夫

言語聴覚研究　18　(3)　170-170　2021/09
Publisher: (一社)日本言語聴覚士協会
ISSN： 1349-5828
【二次出版】ANL Secondary Publication 口蓋扁桃摘出術後の味覚障害の危険因子に関する検討

北谷栞, 菊地俊晶, 八幡湖, 池田怜吉, 野村和弘, 川瀬哲明, 香取幸夫

日本耳鼻咽喉科頭頸部外科学会会報　124　(8)　1223-1224　2021/08
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 2436-5793

eISSN： 2436-5866
ANL Secondary Publication 口蓋扁桃摘出術後の味覚障害の危険因子に関する検討

北谷栞, 菊地俊晶, 八幡湖, 池田怜吉, 野村和弘, 川瀬哲明, 香取幸夫

日本耳鼻咽喉科頭頸部外科学会会報　124　(8)　1223-1224　2021/08
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 2436-5793

eISSN： 2436-5866
全エクソン解析とオルガノイド培養を行った耳下腺CASTLE症例

石川智彦, 小川武則, 香取幸夫

口腔・咽頭科　34　(3)　277-277　2021/08
Publisher: 日本口腔・咽頭科学会
ISSN： 0917-5105

eISSN： 1884-4316
経皮的二酸化炭素分圧測定を行った小児睡眠呼吸障害症例の検討

安達美佳, 香取幸夫

口腔・咽頭科　34　(3)　315-315　2021/08
Publisher: 日本口腔・咽頭科学会
ISSN： 0917-5105

eISSN： 1884-4316
放射線口腔粘膜炎に対するNrf2の防御機構

若盛隼, 小川武則, 香取幸夫

口腔・咽頭科　34　(3)　276-276　2021/08
Publisher: 日本口腔・咽頭科学会
ISSN： 0917-5105

eISSN： 1884-4316
全エクソン解析とオルガノイド培養を行った耳下腺CASTLE症例

石川智彦, 小川武則, 香取幸夫

口腔・咽頭科　34　(3)　277-277　2021/08
Publisher: 日本口腔・咽頭科学会
ISSN： 0917-5105

eISSN： 1884-4316
経皮的二酸化炭素分圧測定を行った小児睡眠呼吸障害症例の検討

安達美佳, 香取幸夫

口腔・咽頭科　34　(3)　315-315　2021/08
Publisher: 日本口腔・咽頭科学会
ISSN： 0917-5105

eISSN： 1884-4316
治療法の再整理とアップデートのために専門家による私の治療嚥下障害

香取幸夫

日本医事新報　(5079)　40-41　2021/08
Publisher: (株)日本医事新報社
ISSN： 0385-9215
【必読!!耳鼻咽喉科医が知っておくべきCOVID-19の知識】耳鼻咽喉科診療と新型コロナウイルス感染症対策ネブライザー療法の可否

角田梨紗子, 香取幸夫

JOHNS　37　(7)　712-714　2021/07
Publisher: (株)東京医学社
ISSN： 0910-6820
多系統萎縮症における嚥下スクリーニング検査の有用性について

平野愛, 大村悠, 馬場徹, 武田篤, 香取幸夫

パーキンソン病・運動障害疾患コングレスプログラム・抄録集　15回　108-108　2021/07
Publisher: Movement Disorder Society of Japan (MDSJ)
東北大学病院耳鼻咽喉・頭頸部外科におけるSARS-CoV-2スクリーニングPCR検査の現状調査

角田梨紗子, 金森肇, 北谷栞, 香取幸夫

日本耳鼻咽喉科免疫アレルギー感染症学会抄録集　1回　141-141　2021/05
Publisher: 日本耳鼻咽喉科免疫アレルギー感染症学会
eISSN： 2435-7987
東北大学病院耳鼻咽喉・頭頸部外科における最近10年間の血液培養検査の現状

北谷栞, 角田梨紗子, 金森肇, 香取幸夫

日本耳鼻咽喉科免疫アレルギー感染症学会抄録集　1回　181-181　2021/05
Publisher: 日本耳鼻咽喉科免疫アレルギー感染症学会
eISSN： 2435-7987
東北大学病院耳鼻咽喉・頭頸部外科におけるSARS-CoV-2スクリーニングPCR検査の現状調査

角田梨紗子, 金森肇, 北谷栞, 香取幸夫

日本耳鼻咽喉科免疫アレルギー感染症学会抄録集　1回　141-141　2021/05
Publisher: 日本耳鼻咽喉科免疫アレルギー感染症学会
eISSN： 2435-7987
声帯ポリープにおけるペリオスチンの発現

舘田豊, 太田伸男, 香取幸夫

日本耳鼻咽喉科免疫アレルギー感染症学会抄録集　1回　143-143　2021/05
Publisher: 日本耳鼻咽喉科免疫アレルギー感染症学会
eISSN： 2435-7987
スギ花粉症に対する舌下免疫療法の副反応に関するアンケート調査

中角美穂, 湯田厚司, 草野佑典, 東海林史, 舘田豊, 鈴木祐輔, 柴原義博, 中林成一郎, 稲村直樹, 香取幸夫, 太田伸男, 岡本美孝

日本耳鼻咽喉科免疫アレルギー感染症学会抄録集　1回　146-146　2021/05
Publisher: 日本耳鼻咽喉科免疫アレルギー感染症学会
eISSN： 2435-7987
東北大学病院耳鼻咽喉・頭頸部外科における最近10年間の血液培養検査の現状

北谷栞, 角田梨紗子, 金森肇, 香取幸夫

日本耳鼻咽喉科免疫アレルギー感染症学会抄録集　1回　181-181　2021/05
Publisher: 日本耳鼻咽喉科免疫アレルギー感染症学会
eISSN： 2435-7987
頭頸部癌治療に関わる嚥下障害および肺炎の発生についての後方視的研究

石井亮, 中山勇樹, 中村和樹, 吉田拓矢, 石川智彦, 若盛隼, 六郷正博, 中目亜矢子, 西條聡, 今井隆之, 山崎知子, 大越明, 浅田行紀, 香取幸夫

頭頸部癌　47　(2)　220-220　2021/05
Publisher: (一社)日本頭頸部癌学会
ISSN： 1349-5747

eISSN： 1881-8382
スギ舌下免疫療法3シーズン目の効果皮下免疫療法との比較

野口直哉, 太田伸男, 湯田厚司, 小川由起子, 草野佑典, 東海林史, 北谷栞, 鈴木直弘, 草刈千賀志, 田畑邦次, 郭冠宏, 沖津尚弘, 長谷川純, 柴原義博, 中林成一郎, 稲村直樹, 大井聖幸, 高梨芳崇, 鈴木淳, 菅原充, 野村和弘, 香取幸夫, 岡本美孝

日本耳鼻咽喉科学会会報　124　(5)　748-755　2021/05
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 0030-6622

eISSN： 1883-0854
頭頸部癌治療に関わる嚥下障害および肺炎の発生についての後方視的研究

石井亮, 中山勇樹, 中村和樹, 吉田拓矢, 石川智彦, 若盛隼, 六郷正博, 中目亜矢子, 西條聡, 今井隆之, 山崎知子, 大越明, 浅田行紀, 香取幸夫

頭頸部癌　47　(2)　220-220　2021/05
Publisher: (一社)日本頭頸部癌学会
ISSN： 1349-5747

eISSN： 1881-8382
唾液腺導管癌の患者由来オルガノイド細胞株を用いた個別化医療モデル

石川智彦, 中目亜矢子, 大越明, 東賢二郎, 石井亮, 六郷正博, 若盛隼, 吉田拓矢, 小川武則, 古川徹, 香取幸夫

日本耳鼻咽喉科学会会報　124　(4)　591-591　2021/04
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 0030-6622

eISSN： 1883-0854
水中内視鏡下半規管充填術を施行した上半規管裂隙症候群症例の術後聴力の検討

川村善宣, 山内大輔, 小林俊光, 池田怜吉, 川瀬哲明, 香取幸夫

日本耳鼻咽喉科学会会報　124　(4)　564-564　2021/04
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 0030-6622

eISSN： 1883-0854
線維素性唾液管炎の原因として好酸球細胞外トラップによる唾液管閉塞が示唆された一症例

川村善宣, 植木重治, 池田怜吉, 堀亨, 佐々木高綱, 宮部結, 福地峰世, 坂元和宏, 太田伸男, 川瀬哲明, 香取幸夫

日本耳鼻咽喉科学会会報　124　(4)　618-618　2021/04
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 0030-6622

eISSN： 1883-0854
真珠腫性中耳炎におけるペリオスチンならびにアスパラギン酸の発現の検討

北谷栞, 鈴木淳, 池田怜吉, 大島英敏, 草野佑典, 川瀬哲明, 太田伸男, 小林俊光, 香取幸夫

日本耳鼻咽喉科学会会報　124　(4)　603-603　2021/04
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 0030-6622

eISSN： 1883-0854
嚥下障害治療の開発医学、歯学、工学の連携

香取幸夫

日本耳鼻咽喉科学会会報　124　(4)　351-354　2021/04
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 0030-6622

eISSN： 1883-0854
水中内視鏡下半規管充填術を施行した上半規管裂隙症候群症例の術後聴力の検討

川村善宣, 山内大輔, 小林俊光, 池田怜吉, 川瀬哲明, 香取幸夫

日本耳鼻咽喉科学会会報　124　(4)　564-564　2021/04
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 0030-6622

eISSN： 1883-0854
唾液腺導管癌の患者由来オルガノイド細胞株を用いた個別化医療モデル

石川智彦, 中目亜矢子, 大越明, 東賢二郎, 石井亮, 六郷正博, 若盛隼, 吉田拓矢, 小川武則, 古川徹, 香取幸夫

日本耳鼻咽喉科学会会報　124　(4)　591-591　2021/04
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 0030-6622

eISSN： 1883-0854
真珠腫性中耳炎におけるペリオスチンならびにアスパラギン酸の発現の検討

北谷栞, 鈴木淳, 池田怜吉, 大島英敏, 草野佑典, 川瀬哲明, 太田伸男, 小林俊光, 香取幸夫

日本耳鼻咽喉科学会会報　124　(4)　603-603　2021/04
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 0030-6622

eISSN： 1883-0854
線維素性唾液管炎の原因として好酸球細胞外トラップによる唾液管閉塞が示唆された一症例

川村善宣, 植木重治, 池田怜吉, 堀亨, 佐々木高綱, 宮部結, 福地峰世, 坂元和宏, 太田伸男, 川瀬哲明, 香取幸夫

日本耳鼻咽喉科学会会報　124　(4)　618-618　2021/04
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 0030-6622

eISSN： 1883-0854
上気道閉塞を来たし内視鏡下鼻腔手術を実施した新生児glial heterotopia症例

逸見朋隆, 鈴木淳, 佐藤聡子, 生島寛享, 小川武則, 香取幸夫

日本鼻科学会会誌　60　(1)　21-27　2021/04
Publisher: (一社)日本鼻科学会
ISSN： 0910-9153

eISSN： 1883-7077
【術前画像と術中解剖-カンファレンスで突っ込まれないための知識】咽頭・喉頭領域嚥下障害に対する手術

香取幸夫

耳鼻咽喉科・頭頸部外科　93　(5)　196-203　2021/04
Publisher: (株)医学書院
ISSN： 0914-3491

eISSN： 1882-1316
長期集中治療を要した続発性喉頭麻痺を伴う重度嚥下障害症例に対する誤嚥防止術症例報告

宮川乃理子, 野村亮介, 佐藤哲哉, 大村拓, 香取幸夫, 久志本成樹

日本救急医学会雑誌　32　(3)　138-143　2021/03
Publisher: (一社)日本救急医学会
ISSN： 0915-924X

eISSN： 1883-3772
外来診療における私の処置咽喉頭の処置永久気管孔の処置

大越明, 香取幸夫

JOHNS　37　(2)　203-205　2021/02
Publisher: (株)東京医学社
ISSN： 0910-6820
【最新の花粉症診療】最新の花粉症診療アレルギー性鼻炎の外科的治療

香取幸夫, 鈴木淳, 逸見朋隆

診断と治療　109　(2)　221-224　2021/02
Publisher: (株)診断と治療社
ISSN： 0370-999X
外来診療における私の処置咽喉頭の処置永久気管孔の処置

大越明, 香取幸夫

JOHNS　37　(2)　203-205　2021/02
Publisher: (株)東京医学社
ISSN： 0910-6820
【最新の花粉症診療】最新の花粉症診療アレルギー性鼻炎の外科的治療

香取幸夫, 鈴木淳, 逸見朋隆

診断と治療　109　(2)　221-224　2021/02
Publisher: (株)診断と治療社
ISSN： 0370-999X
甲状腺の取扱いに配慮した食道癌集学的治療後のハイリスク下咽頭喉頭摘出術の一例(気管壊死症例との比較)

石井亮, 大越明, 中山勇樹, 東賢二郎, 中目亜矢子, 岡本宏史, 谷山裕亮, 香取幸夫

日本気管食道科学会総会ならびに学術講演会プログラム・予稿集　72nd　(2)　s42-s42　2021
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
頭頸部再建手術における高齢者機能評価スクリーニングツール(G8)の合併症予測に対する有用性

中山勇樹, 大越明, 石井亮, 中目亜矢子, 東賢二郎, 香取幸夫

日本気管食道科学会総会ならびに学術講演会プログラム・予稿集　72nd　(2)　s22-s22　2021
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
Dynamic measurement of food in pharynx and larynx using near-infrared fluorescence

若松海門, 田代剛大, 山田幸生, 丹羽治樹, 牧昌次郎, 牧昌次郎, 小池卓二, 小池卓二, 道脇幸博, 西村吾朗, 山内大輔, 川村善宣, 香取幸夫

Optics & Photonics Japan講演予稿集(CD-ROM)　2021　2021
聴性誘発脳磁界N100m反応に認められる音楽による対側耳マスキング効果

白倉真之, 川瀬哲明, 川瀬哲明, 菅野彰剛, 菅野彰剛, 太田淳, 中里信和, 中里信和, 川島隆太, 香取幸夫

臨床神経生理学(Web)　49　(5)　2021

ISSN： 2188-031X
慢性副鼻腔炎手術症例の呼吸機能の検討

逸見朋隆, 鈴木淳, 小林祐太, 野村和弘, 菅原充, 香取幸夫

日本鼻科学会会誌　59　(4)　297-302　2020/12
Publisher: (一社)日本鼻科学会
ISSN： 0910-9153

eISSN： 1883-7077
先端医学講座線維素性唾液腺管炎好酸球細胞外トラップによる唾液管閉塞の可能性

川村善宣, 植木重治, 福地峰世, 宮部結, 香取幸夫

アレルギーの臨床　40　(13)　1087-1091　2020/12
Publisher: (株)北隆館
ISSN： 0285-6379
【高齢者の誤嚥をみたらどうするか】嚥下障害診療における地域連携の進め方

加藤健吾, 香取幸夫

ENTONI　(252)　63-68　2020/12
Publisher: (株)全日本病院出版会
ISSN： 1346-2067
新生児glial heterotopiaの一例

逸見朋隆, 鈴木淳, 生島寛享, 小川武則, 香取幸夫

日本鼻科学会会誌　59　(Suppl.)　S80-S80　2020/12
Publisher: (一社)日本鼻科学会
ISSN： 0910-9153

eISSN： 1883-7077
摂食・嚥下センター外来における医科歯科連携と5年間の治療実績

池田怜吉, 平野愛, 香取幸夫

耳鼻咽喉科臨床補冊　(補冊155)　112-112　2020/12
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
慢性副鼻腔炎手術症例の呼吸機能の検討

逸見朋隆, 鈴木淳, 小林祐太, 野村和弘, 菅原充, 香取幸夫

日本鼻科学会会誌　59　(4)　297-302　2020/12
Publisher: (一社)日本鼻科学会
ISSN： 0910-9153

eISSN： 1883-7077
摂食・嚥下センター外来における医科歯科連携と5年間の治療実績

池田怜吉, 平野愛, 香取幸夫

耳鼻咽喉科臨床補冊　(補冊155)　112-112　2020/12
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
【高齢者の誤嚥をみたらどうするか】嚥下障害診療における地域連携の進め方

加藤健吾, 香取幸夫

ENTONI　(252)　63-68　2020/12
Publisher: (株)全日本病院出版会
ISSN： 1346-2067
新生児glial heterotopiaの一例

逸見朋隆, 鈴木淳, 生島寛享, 小川武則, 香取幸夫

日本鼻科学会会誌　59　(Suppl.)　S80-S80　2020/12
Publisher: (一社)日本鼻科学会
ISSN： 0910-9153

eISSN： 1883-7077
先端医学講座線維素性唾液腺管炎好酸球細胞外トラップによる唾液管閉塞の可能性

川村善宣, 植木重治, 福地峰世, 宮部結, 香取幸夫

アレルギーの臨床　40　(13)　1087-1091　2020/12
Publisher: (株)北隆館
ISSN： 0285-6379
当院におけるALS患者に対する誤嚥防止術5例の長期経過

曽我天馬, 井泉瑠美子, 鈴木直輝, 川内裕子, 加藤健吾, 香取幸夫, 青木正志, 加藤昌昭

臨床神経学　60　(Suppl.)　S450-S450　2020/11
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
音声治療を行った小児の3症例

香取幸夫

小児耳鼻咽喉科　41　(2)　174-174　2020/11
Publisher: 日本小児耳鼻咽喉科学会
ISSN： 0919-5858

eISSN： 2186-5957
高炭酸ガス血症を伴う低換気と重症閉塞性睡眠時無呼吸を伴うプラダー・ウィリ症候群の1例

安達美佳, 白倉真之, 逸見朋隆, 香取幸夫

小児耳鼻咽喉科　41　(2)　209-209　2020/11
Publisher: 日本小児耳鼻咽喉科学会
ISSN： 0919-5858

eISSN： 2186-5957
当院NSTにおけるNST加算の現状と課題

稲村なお子, 武田みゆき, 佐々木まなみ, 布田美貴子, 元井冬彦, 香取幸夫

学会誌JSPEN　2　(Suppl.1)　311-311　2020/11
Publisher: (一社)日本臨床栄養代謝学会
eISSN： 2434-4966
亜セレン酸注の経静脈投与によるセレン血中濃度上昇に影響を与える因子の探索

八島一史, 前川正充, 前嶋隆弘, 吉中千佳, 伊関雅裕, 久道周彦, 元井冬彦, 香取幸夫

学会誌JSPEN　2　(Suppl.1)　1520-1520　2020/11
Publisher: (一社)日本臨床栄養代謝学会
eISSN： 2434-4966
鼓膜の呼吸性動揺が臥位でも観察された耳管開放症症例確実例における頻度について

草野佑典, 川村善宣, 池田怜吉, 大島英敏, 菊地俊晶, 香取幸夫, 小林俊光

日本耳科学会総会・学術講演会抄録集　30回　170-170　2020/11
Publisher: (一社)日本耳科学会
当院におけるALS患者に対する誤嚥防止術5例の長期経過

曽我天馬, 井泉瑠美子, 鈴木直輝, 川内裕子, 加藤健吾, 香取幸夫, 青木正志, 加藤昌昭

臨床神経学　60　(Suppl.)　S450-S450　2020/11
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
当科における鼻骨骨折の臨床的な検討

北谷栞, 太田伸男, 齋藤雄太郎, 舘田豊, 野口直哉, 山崎宗治, 高梨芳崇, 鈴木貴博, 東海林史, 高橋由紀子, 八木沼裕司, 松谷幸子, 草野佑典, 池田怜吉, 鈴木淳, 角田梨紗子, 野村和弘, 菅原充, 香取幸夫

日本耳鼻咽喉科学会会報　123　(11)　1283-1289　2020/11
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
当院NSTにおけるNST加算の現状と課題

稲村なお子, 武田みゆき, 佐々木まなみ, 布田美貴子, 元井冬彦, 香取幸夫

学会誌JSPEN　2　(Suppl.1)　311-311　2020/11
Publisher: (一社)日本臨床栄養代謝学会
eISSN： 2434-4966
亜セレン酸注の経静脈投与によるセレン血中濃度上昇に影響を与える因子の探索

八島一史, 前川正充, 前嶋隆弘, 吉中千佳, 伊関雅裕, 久道周彦, 元井冬彦, 香取幸夫

学会誌JSPEN　2　(Suppl.1)　1520-1520　2020/11
Publisher: (一社)日本臨床栄養代謝学会
eISSN： 2434-4966
音声治療を行った小児の3症例

香取幸夫

小児耳鼻咽喉科　41　(2)　174-174　2020/11
Publisher: 日本小児耳鼻咽喉科学会
ISSN： 0919-5858

eISSN： 2186-5957
高炭酸ガス血症を伴う低換気と重症閉塞性睡眠時無呼吸を伴うプラダー・ウィリ症候群の1例

安達美佳, 白倉真之, 逸見朋隆, 香取幸夫

小児耳鼻咽喉科　41　(2)　209-209　2020/11
Publisher: 日本小児耳鼻咽喉科学会
ISSN： 0919-5858

eISSN： 2186-5957
鼓膜の呼吸性動揺が臥位でも観察された耳管開放症症例確実例における頻度について

草野佑典, 川村善宣, 池田怜吉, 大島英敏, 菊地俊晶, 香取幸夫, 小林俊光

日本耳科学会総会・学術講演会抄録集　30回　170-170　2020/11
Publisher: (一社)日本耳科学会
当科における鼻骨骨折の臨床的な検討

北谷栞, 太田伸男, 齋藤雄太郎, 舘田豊, 野口直哉, 山崎宗治, 高梨芳崇, 鈴木貴博, 東海林史, 高橋由紀子, 八木沼裕司, 松谷幸子, 草野佑典, 池田怜吉, 鈴木淳, 角田梨紗子, 野村和弘, 菅原充, 香取幸夫

日本耳鼻咽喉科学会会報　123　(11)　1283-1289　2020/11
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
高齢者諸機能低下メカニズムの解明基礎系・臨床系研究成果の統合的議論

阿部伸一, 香取幸夫, 日向信之, 石田瞭, 大久保真衣, 山本仁, 北村啓, 山本将仁

歯科学報　120　(3)　255-258　2020/10
Publisher: 東京歯科大学学会
ISSN： 0037-3710
上半規管裂隙症候群における水中内視鏡下耳科手術による閉塞術の手技と利点

山内大輔, 川村善宣, 本藏陽平, 小林俊光, 池田怜吉, 宮崎浩充, 川瀬哲明, 香取幸夫

Otology Japan　30　(3)　159-166　2020/10
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
勤務医のページ嚥下障害診療耳鼻咽喉科が貢献できること

香取幸夫

宮城県医師会報　(897)　800-800　2020/10
Publisher: (公社)宮城県医師会
上半規管裂隙症候群における水中内視鏡下耳科手術による閉塞術の手技と利点

山内大輔, 川村善宣, 本藏陽平, 小林俊光, 池田怜吉, 宮崎浩充, 川瀬哲明, 香取幸夫

Otology Japan　30　(3)　159-166　2020/10
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
高齢者諸機能低下メカニズムの解明基礎系・臨床系研究成果の統合的議論

阿部伸一, 香取幸夫, 日向信之, 石田瞭, 大久保真衣, 山本仁, 北村啓, 山本将仁

歯科学報　120　(3)　255-258　2020/10
Publisher: 東京歯科大学学会
ISSN： 0037-3710
勤務医のページ嚥下障害診療耳鼻咽喉科が貢献できること

香取幸夫

宮城県医師会報　(897)　800-800　2020/10
Publisher: (公社)宮城県医師会
健康長寿に向けての耳鼻咽喉科の役割高齢者の嚥下障害を診る

香取幸夫

日本耳鼻咽喉科学会会報　123　(4)　911-911　2020/09
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
乳幼児の咽頭金属異物の2例

小泉祥太郎, 鈴木淳, 渡邊健一, 本藏陽平, 川村善宣, 逸見朋隆, 渡来剛右, 遠藤拓弥, 石垣賢人, 香取幸夫

日本耳鼻咽喉科学会会報　123　(4)　1099-1099　2020/09
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
中耳のfourth jointであるキヌタ骨-錐体骨関節ヒト胎児研究(The incudopetrosal joint, the fourth joint in the middle ear: A study in human fetuses)

香取幸夫, Rodriguez-Vazquez Jose F

日本耳鼻咽喉科学会会報　123　(4)　1133-1133　2020/09
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
【耳鼻咽喉科診療Q&A】頸部領域、頭頸部腫瘍下顎切除後の機能温存の治療をどのようにしていますか?

大越明, 黒沢是之, 宮下仁, 佐藤奈央子, 中目亜矢子, 小川武則, 香取幸夫

JOHNS　36　(9)　1283-1285　2020/09
Publisher: (株)東京医学社
ISSN： 0910-6820
Varicella-zoster virus再活性化により、嚥下障害を来した1例

中山勇樹, 若盛隼, 小澤大樹, 柳葉久実, 大島英敏, 田畑摩純, 香取幸夫

いわき市医療センター医報　41　(1)　51-54　2020/09
Publisher: いわき市医療センター
ISSN： 2434-7183
【耳鼻咽喉科診療Q&A】頸部領域、頭頸部腫瘍下顎切除後の機能温存の治療をどのようにしていますか?

大越明, 黒沢是之, 宮下仁, 佐藤奈央子, 中目亜矢子, 小川武則, 香取幸夫

JOHNS　36　(9)　1283-1285　2020/09
Publisher: (株)東京医学社
ISSN： 0910-6820
健康長寿に向けての耳鼻咽喉科の役割高齢者の嚥下障害を診る

香取幸夫

日本耳鼻咽喉科学会会報　123　(4)　911-911　2020/09
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
乳幼児の咽頭金属異物の2例

小泉祥太郎, 鈴木淳, 渡邊健一, 本藏陽平, 川村善宣, 逸見朋隆, 渡来剛右, 遠藤拓弥, 石垣賢人, 香取幸夫

日本耳鼻咽喉科学会会報　123　(4)　1099-1099　2020/09
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
中耳のfourth jointであるキヌタ骨-錐体骨関節ヒト胎児研究(The incudopetrosal joint, the fourth joint in the middle ear: A study in human fetuses)

香取幸夫, Rodriguez-Vazquez Jose F

日本耳鼻咽喉科学会会報　123　(4)　1133-1133　2020/09
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
頭頸部癌化学放射線治療前後の嚥下評価方法の検証嚥下内視鏡・造影検査の経時比較

石井亮, 加藤健吾, 大越明, 佐藤剛史, 平野愛, 小川武則, 香取幸夫

口腔・咽頭科　33　(3)　175-175　2020/08
Publisher: 日本口腔・咽頭科学会
ISSN： 0917-5105

eISSN： 1884-4316
【耳鼻咽喉科領域の外傷を診る!-初期対応から根治療法まで】口腔外傷

永井宏和, 高橋哲, 小川武則, 香取幸夫

耳鼻咽喉科・頭頸部外科　92　(7)　522-526　2020/06
Publisher: (株)医学書院
ISSN： 0914-3491

eISSN： 1882-1316
【鼻とのどの局所治療】のどの局所治療咽喉頭異常感症の局所治療

香取幸夫

JOHNS　36　(6)　737-738　2020/06
Publisher: (株)東京医学社
ISSN： 0910-6820
スギ花粉症に対する舌下免疫療法の1〜4シーズン目のアンケート調査

草野佑典, 太田伸男, 湯田厚司, 小川由起子, 東海林史, 粟田口敏一, 鈴木直弘, 千葉敏彦, 陳志傑, 草刈千賀志, 武田広誠, 神林潤一, 志賀伸之, 大竹祐輔, 鈴木祐輔, 柴原義博, 中林成一郎, 稲村直樹, 長舩大士, 和田弘太, 欠畑誠治, 香取幸夫, 岡本美孝

日本耳鼻咽喉科学会会報　123　(6)　469-475　2020/06
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
【鼻とのどの局所治療】のどの局所治療咽喉頭異常感症の局所治療

香取幸夫

JOHNS　36　(6)　737-738　2020/06
Publisher: (株)東京医学社
ISSN： 0910-6820
NTRK3に2ヶ所のbreak pointを有し非典型的組織像を示した唾液腺分泌癌症例分泌癌10例の分子病理学的検討

石川智彦, 臼渕肇, 小川武則, 沼野佑樹, 香取幸夫, 長尾俊孝, 古川徹

日本病理学会会誌　109　(1)　290-290　2020/03
Publisher: (一社)日本病理学会
ISSN： 0300-9181
膵癌細胞株におけるMAPK pathwayに関連したlong non-coding RNAの解析

石川智彦, 小川武則, 香取幸夫, 古川徹

日本病理学会会誌　109　(1)　323-323　2020/03
Publisher: (一社)日本病理学会
ISSN： 0300-9181
NTRK3に2ヶ所のbreak pointを有し非典型的組織像を示した唾液腺分泌癌症例分泌癌10例の分子病理学的検討

石川智彦, 臼渕肇, 小川武則, 沼野佑樹, 香取幸夫, 長尾俊孝, 古川徹

日本病理学会会誌　109　(1)　290-290　2020/03
Publisher: (一社)日本病理学会
ISSN： 0300-9181
膵癌細胞株におけるMAPK pathwayに関連したlong non-coding RNAの解析

石川智彦, 小川武則, 香取幸夫, 古川徹

日本病理学会会誌　109　(1)　323-323　2020/03
Publisher: (一社)日本病理学会
ISSN： 0300-9181
【カラーアトラス口腔・咽頭粘膜疾患-目で見て覚える鑑別ポイント】咽頭粘膜の悪性腫瘍

中山勇樹, 小川武則, 大越明, 中目亜矢子, 吉田拓矢, 小泉祥太郎, 香取幸夫

耳鼻咽喉科・頭頸部外科　92　(2)　152-160　2020/02
Publisher: (株)医学書院
ISSN： 0914-3491

eISSN： 1882-1316
【カラーアトラス口腔・咽頭粘膜疾患-目で見て覚える鑑別ポイント】咽頭粘膜の悪性腫瘍

中山勇樹, 小川武則, 大越明, 中目亜矢子, 吉田拓矢, 小泉祥太郎, 香取幸夫

耳鼻咽喉科・頭頸部外科　92　(2)　152-160　2020/02
Publisher: (株)医学書院
ISSN： 0914-3491

eISSN： 1882-1316
筋萎縮性側索硬化症に対し喉頭中央部切除を施行した12例の報告

加藤健吾, 加藤昌昭, 川内裕子, 岩崎さや香, 佐藤剛史, 河本愛, 香取幸夫

日本摂食・嚥下リハビリテーション学会雑誌　23　(3)　S271-S271　2019/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
声帯麻痺症例の検討

長谷川航世, 渡邊健一, 本藏陽平, 鹿島和孝, 平野愛, 佐藤剛史, 香取幸夫

喉頭　31　(2)　163-167　2019/12
Publisher: 日本喉頭科学会
ISSN： 0915-6127

eISSN： 2185-4696
難治性誤嚥に対して喉頭中央部切除術を施行した2例

三橋友里, 阿部尚央, 香取幸夫, 松原篤

喉頭　31　(2)　171-175　2019/12
Publisher: 日本喉頭科学会
ISSN： 0915-6127

eISSN： 2185-4696
担がん状態で就労する在宅経腸栄養管理患者に対し継続的な栄養介入を行った1例

西川祐未, 稲村なお子, 佐々木まなみ, 布田美貴子, 元井冬彦, 香取幸夫

東北医学雑誌　131　(2)　168-168　2019/12
Publisher: 東北医学会
ISSN： 0040-8700
【二次出版】ANL Secondary Publication ステロイドパルス療法はIgA腎症の扁桃の組織学的構造に影響を与えるが、経時的に回復する

安達美佳, 佐藤光博, 宮崎真理子, 堀田修, 朴澤孝治, 佐藤壽伸, 田熊淑男, 香取幸夫

日本耳鼻咽喉科学会会報　122　(12)　1559-1560　2019/12
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
舌切除に伴う構音・摂食嚥下障害をチームアプローチにより改善した1症例

泉田一賢, 岩崎さや香, 小山重人, 佐藤奈央子, 互野亮, 加藤健吾, 香取幸夫, 佐々木啓一

顎顔面補綴　42　(2)　113-114　2019/12
Publisher: (一社)日本顎顔面補綴学会
ISSN： 0389-4045
ANL Secondary Publication ステロイドパルス療法はIgA腎症の扁桃の組織学的構造に影響を与えるが、経時的に回復する

安達美佳, 佐藤光博, 宮崎真理子, 堀田修, 朴澤孝治, 佐藤壽伸, 田熊淑男, 香取幸夫

日本耳鼻咽喉科学会会報　122　(12)　1559-1560　2019/12
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
舌切除に伴う構音・摂食嚥下障害をチームアプローチにより改善した1症例

泉田一賢, 岩崎さや香, 小山重人, 佐藤奈央子, 互野亮, 加藤健吾, 香取幸夫, 佐々木啓一

顎顔面補綴　42　(2)　113-114　2019/12
Publisher: (一社)日本顎顔面補綴学会
ISSN： 0389-4045
頭蓋底手術を施行した鼻腔原発腸管型腺癌の1例

中村和樹, 小川武則, 中目亜矢子, 大越明, 石田英一, 六郷正博, 石川智彦, 若盛隼, 吉田拓矢, 香取幸夫

頭頸部癌　45　(3)　337-341　2019/10
Publisher: (一社)日本頭頸部癌学会
ISSN： 1349-5747

eISSN： 1881-8382
日本における検体を用いた手術研修の状況(The situation of surgical training using donated cadavers in Japan)

香取幸夫

日本耳科学会総会・学術講演会抄録集　29回　17-17　2019/10
Publisher: (一社)日本耳科学会
当科での軟骨伝導補聴器の装用・評価の報告

宮倉裕也, 山内大輔, 佐藤剛史, 高井俊輔, 本藏陽平, 安達美佳, 白倉真之, 香取幸夫

日本耳科学会総会・学術講演会抄録集　29回　204-204　2019/10
Publisher: (一社)日本耳科学会
一側小耳症における顔面神経並びにアブミ骨筋の走行の検討

日高浩史, 池田怜吉, 香取幸夫, 鈴鹿有子, 岩井大, 小林俊光

日本耳科学会総会・学術講演会抄録集　29回　238-238　2019/10
Publisher: (一社)日本耳科学会
骨導補聴器の装用が困難であったクルーゾン症候群児に対し、軟骨伝導補聴器で良好な補聴が得られた1例

白倉真之, 安達美佳, 佐藤剛史, 宮倉裕也, 高井俊輔, 本藏陽平, 山内大輔, 川瀬哲明, 香取幸夫

日本耳科学会総会・学術講演会抄録集　29回　277-277　2019/10
Publisher: (一社)日本耳科学会
Yamauchi法による上半規管裂隙症候群の治療-5症例の経験

川村善宣, 小林俊光, 池田怜吉, 宮崎浩充, 本蔵陽平, 山内大輔, 川瀬哲明, 香取幸夫

日本耳科学会総会・学術講演会抄録集　29回　352-352　2019/10
Publisher: (一社)日本耳科学会
内耳における酸化ストレス障害に対する転写因子NRF2の機能の解明

大石哲也, 本蔵陽平, 川瀬哲明, 香取幸夫

日本耳科学会総会・学術講演会抄録集　29回　466-466　2019/10
Publisher: (一社)日本耳科学会
The situation of surgical training using donated cadavers in Japan(和訳中)

香取幸夫

日本耳科学会総会・学術講演会抄録集　29回　17-17　2019/10
Publisher: (一社)日本耳科学会
当科での軟骨伝導補聴器の装用・評価の報告

宮倉裕也, 山内大輔, 佐藤剛史, 高井俊輔, 本藏陽平, 安達美佳, 白倉真之, 香取幸夫

日本耳科学会総会・学術講演会抄録集　29回　204-204　2019/10
Publisher: (一社)日本耳科学会
一側小耳症における顔面神経並びにアブミ骨筋の走行の検討

日高浩史, 池田怜吉, 香取幸夫, 鈴鹿有子, 岩井大, 小林俊光

日本耳科学会総会・学術講演会抄録集　29回　238-238　2019/10
Publisher: (一社)日本耳科学会
骨導補聴器の装用が困難であったクルーゾン症候群児に対し、軟骨伝導補聴器で良好な補聴が得られた1例

白倉真之, 安達美佳, 佐藤剛史, 宮倉裕也, 高井俊輔, 本藏陽平, 山内大輔, 川瀬哲明, 香取幸夫

日本耳科学会総会・学術講演会抄録集　29回　277-277　2019/10
Publisher: (一社)日本耳科学会
Yamauchi法による上半規管裂隙症候群の治療-5症例の経験

川村善宣, 小林俊光, 池田怜吉, 宮崎浩充, 本蔵陽平, 山内大輔, 川瀬哲明, 香取幸夫

日本耳科学会総会・学術講演会抄録集　29回　352-352　2019/10
Publisher: (一社)日本耳科学会
内耳における酸化ストレス障害に対する転写因子NRF2の機能の解明

大石哲也, 本蔵陽平, 川瀬哲明, 香取幸夫

日本耳科学会総会・学術講演会抄録集　29回　466-466　2019/10
Publisher: (一社)日本耳科学会
頭蓋底手術を施行した鼻腔原発腸管型腺癌の1例

中村和樹, 小川武則, 中目亜矢子, 大越明, 石田英一, 六郷正博, 石川智彦, 若盛隼, 吉田拓矢, 香取幸夫

頭頸部癌　45　(3)　337-341　2019/10
Publisher: (一社)日本頭頸部癌学会
DOI： 10.5981/jjhnc.45.337 　

ISSN： 1349-5747
嚥下手術私の術式(series 15) 輪状咽頭筋切断術・喉頭挙上術併施(2)

河本勝之, 加藤健吾, 香取幸夫, 二藤隆春

嚥下医学　8　(2)　153-166　2019/09
Publisher: 日本嚥下医学会
ISSN： 2186-3199
上顎洞Rosai-Dorfman病の一例

鈴木淳, 生島寛享, 逸見朋隆, 野村和弘, 菅原充, 香取幸夫

日本鼻科学会会誌　58　(3)　527-527　2019/09
Publisher: (一社)日本鼻科学会
ISSN： 0910-9153

eISSN： 1883-7077
呼吸機能検査における末梢気道閉塞所見は好酸球性副鼻腔炎の存在を示唆するか?

逸見朋隆, 鈴木淳, 野村和弘, 菅原充, 香取幸夫

日本鼻科学会会誌　58　(3)　562-562　2019/09
Publisher: (一社)日本鼻科学会
ISSN： 0910-9153

eISSN： 1883-7077
癌幹細胞マーカーCD271を標的とした抗体治療の検討(Humanized anti-CD271 monoclonal antibody exerts an anti-tumor effect by depleting cancer stem cells)

森田真吉, 望月麻衣, 渋谷莉恵, 中村真央, 山口壹範, 今井隆之, 浅田行紀, 松浦一登, 菅村和夫, 香取幸夫, 佐藤賢一, 玉井恵一

日本癌学会総会記事　78回　P-2173　2019/09
Publisher: (一社)日本癌学会
ISSN： 0546-0476
上顎洞Rosai-Dorfman病の一例

鈴木淳, 生島寛享, 逸見朋隆, 野村和弘, 菅原充, 香取幸夫

日本鼻科学会会誌　58　(3)　527-527　2019/09
Publisher: (一社)日本鼻科学会
ISSN： 0910-9153

eISSN： 1883-7077
呼吸機能検査における末梢気道閉塞所見は好酸球性副鼻腔炎の存在を示唆するか?

逸見朋隆, 鈴木淳, 野村和弘, 菅原充, 香取幸夫

日本鼻科学会会誌　58　(3)　562-562　2019/09
Publisher: (一社)日本鼻科学会
ISSN： 0910-9153

eISSN： 1883-7077
【嚥下障害を診る!-プロに学ぶ実践スキル】嚥下障害の診かた

香取幸夫

耳鼻咽喉科・頭頸部外科　91　(10)　806-809　2019/09
Publisher: (株)医学書院
ISSN： 0914-3491

eISSN： 1882-1316
【私はこうしている-口腔咽喉頭頸部手術編】口腔・咽頭手術下顎悪性腫瘍切除術下顎骨区域切除

小川武則, 黒沢是之, 宮下仁, 佐藤奈央子, 大越明, 中目亜矢子, 吉田拓矢, 石川健一朗, 遠藤拓弥, 香取幸夫

JOHNS　35　(9)　1093-1096　2019/09
Publisher: (株)東京医学社
ISSN： 0910-6820
【私はこうしている-口腔咽喉頭頸部手術編】頸部・甲状腺・食道手術術後瘻孔閉鎖術

大越明, 黒沢是之, 小川武則, 中目亜矢子, 吉田拓矢, 香取幸夫

JOHNS　35　(9)　1339-1342　2019/09
Publisher: (株)東京医学社
ISSN： 0910-6820
【私はこうしている-口腔咽喉頭頸部手術編】嚥下障害の手術誤嚥防止術狭域の喉頭摘出術

加藤健吾, 平野愛, 香取幸夫

JOHNS　35　(9)　1365-1368　2019/09
Publisher: (株)東京医学社
ISSN： 0910-6820
癌幹細胞マーカーCD271を標的とした抗体治療の検討(Humanized anti-CD271 monoclonal antibody exerts an anti-tumor effect by depleting cancer stem cells)

森田真吉, 望月麻衣, 渋谷莉恵, 中村真央, 山口壹範, 今井隆之, 浅田行紀, 松浦一登, 菅村和夫, 香取幸夫, 佐藤賢一, 玉井恵一

日本癌学会総会記事　78回　P-2173　2019/09
Publisher: 日本癌学会
ISSN： 0546-0476
アクティブシニアライフ実現に向けた耳鼻咽喉科的アプローチ耳鼻咽喉科と医工学との連携による嚥下診療へのアプローチ

香取幸夫

耳鼻咽喉科臨床補冊　(補冊154)　43-43　2019/06
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
東京ボイスセンターにおける局所麻酔下日帰り声帯ポリープ・結節切除術の手術成績

廣崎真柚, 坂口優, 許斐氏元, 中村一博, 香取幸夫, 渡邊雄介

耳鼻咽喉科臨床補冊　(補冊154)　55-55　2019/06
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
東北大学における下咽頭癌200例の臨床統計

中目亜矢子, 小川武則, 嵯峨井俊, 大越明, 東賢二郎, 石井亮, 香取幸夫

耳鼻咽喉科展望　62　(補冊1)　22-23　2019/06
Publisher: 耳鼻咽喉科展望会
ISSN： 0386-9687

eISSN： 1883-6429
東北大学における舌癌を除く口腔癌179例の臨床統計

小川武則, 中目亜矢子, 石井亮, 嵯峨井俊, 大越明, 東賢二郎, 加藤健吾, 香取幸夫

耳鼻咽喉科展望　62　(補冊1)　48-49　2019/06
Publisher: 耳鼻咽喉科展望会
ISSN： 0386-9687

eISSN： 1883-6429
スギ花粉症に対する舌下免疫療法の副反応に関する検討

草野佑典, 太田伸男, 湯田厚司, 佐竹雅史, 東海林史, 齋藤雄太郎, 鈴木直弘, 草刈千賀志, 柴原義博, 稲村直樹, 鈴木祐輔, 香取幸夫, 岡本美孝

耳鼻咽喉科免疫アレルギー　37　(2)　66-66　2019/06
Publisher: 日本耳鼻咽喉科免疫アレルギー学会
ISSN： 0913-0691

eISSN： 2185-5900
切除不能再発転移頭頸部扁平上皮癌患者に対するニボルマブの有効性および安全性に関する後方視的検討

中目亜矢子, 香取幸夫

耳鼻咽喉科免疫アレルギー　37　(2)　120-120　2019/06
Publisher: 日本耳鼻咽喉科免疫アレルギー学会
ISSN： 0913-0691

eISSN： 2185-5900
【嚥下障害と誤嚥性肺炎】嚥下障害に対する対応嚥下障害の手術治療

香取幸夫, 加藤健吾, 平野愛

Clinical Neuroscience　37　(5)　586-589　2019/05
Publisher: (株)中外医学社
ISSN： 0289-0585
頭頸部癌の薬物治療の今後の展開局所進行頭頸部扁平上皮癌に対する導入化学療法

小川武則, 中目亜矢子, 榎田智弘, 本間明宏, 大上研二, 南修司郎, 岩江信法, 清水康, 槇大輔, 上田百合, 藤澤孝夫, 茂木厚, 野村尚吾, 香取幸夫, 田原信

頭頸部癌　45　(2)　114-114　2019/05
Publisher: (一社)日本頭頸部癌学会
ISSN： 1349-5747

eISSN： 1881-8382
頭頸部癌診療における高齢者機能評価スクリーニングツールG8の役割

石井亮, 小川武則, 大越明, 中目亜矢子, 六郷正博, 香取幸夫

頭頸部癌　45　(2)　128-128　2019/05
Publisher: (一社)日本頭頸部癌学会
ISSN： 1349-5747

eISSN： 1881-8382
高齢者の嚥下障害を診る

香取幸夫

日本老年医学会雑誌　56　(Suppl.)　42-42　2019/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
Ndufs4欠損マウスにおける顎下腺・副腎の形態異常とステロイド合成障害

小林祐太, 本藏陽平, 阿部高明, 大和田祐二, 香取幸夫

耳鼻咽喉科ニューロサイエンス　33　38-41　2019/05
Publisher: 耳鼻咽喉科ニューロサイエンス研究会
16S ribosomal RNA遺伝子解析が有用であったnon-typeable Haemophilus influenzaeによる髄膜炎症例

角田梨紗子, 野口直哉, 鈴木貴博, 東海林史, 粟田口敏一, 太田伸男, 樋口じゅん, 八田益充, 賀来満夫, 香取幸夫

耳鼻咽喉科ニューロサイエンス　33　86-89　2019/05
Publisher: 耳鼻咽喉科ニューロサイエンス研究会
嚥下障害診療における医療連携大学の役割

香取幸夫

日本耳鼻咽喉科学会会報　122　(4)　435-435　2019/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
一側小耳症における顔面神経ならびにアブミ骨筋の走行の検討

池田怜吉, 日高浩史, 香取幸夫, 太田伸男, 小林俊光

日本耳鼻咽喉科学会会報　122　(4)　594-594　2019/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
Underwater法による人工内耳埋め込み術の灌流液について

山内大輔, 本蔵陽平, 清水佑一, 橋本光, 舘田豊, 鈴木淳, 日高浩史, 川瀬哲明, 香取幸夫

日本耳鼻咽喉科学会会報　122　(4)　614-614　2019/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
【救急・当直マニュアル-いざというときの対応法】症状からみた鑑別診断音声障害

香取幸夫

耳鼻咽喉科・頭頸部外科　91　(5)　87-90　2019/04
Publisher: (株)医学書院
ISSN： 0914-3491

eISSN： 1882-1316
神経線維腫症II型患者に人工内耳挿入後、MRIにより人工内耳磁石逸脱を来した1例

日高浩史, 須納瀬知輝, 本蔵陽平, 山内大輔, 香取幸夫

日本耳鼻咽喉科学会会報　122　(4)　615-615　2019/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
中耳真珠腫における半規管瘻孔に対する、水中内視鏡下での瘻孔閉鎖術の検討

本蔵陽平, 山内大輔, 清水佑一, 橋本光, 舘田豊, 香取幸夫

日本耳鼻咽喉科学会会報　122　(4)　617-617　2019/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
頭蓋底浸潤頭頸部悪性腫瘍のMRI像

小川武則, 中目亜矢子, 大越明, 六郷正博, 若盛隼, 吉田拓矢, 臼渕肇, 香取幸夫

日本耳鼻咽喉科学会会報　122　(4)　632-632　2019/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
下咽頭癌の癌幹細胞マーカーCD271を標的とした抗体治療の検討

森田真吉, 望月麻衣, 今井隆之, 浅田行紀, 松浦一登, 香取幸夫, 玉井恵一

日本耳鼻咽喉科学会会報　122　(4)　663-663　2019/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
輪状軟骨後板を温存した喉頭中央部切除術変法の長期予後の検討

加藤健吾, 平野愛, 香取幸夫

日本耳鼻咽喉科学会会報　122　(4)　669-669　2019/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
アンケートを用いたスギ花粉症に対する舌下免疫療法の治療開始時期に関する検討

草野佑典, 太田伸男, 湯田厚司, 齋藤雄太郎, 野口直哉, 東海林史, 草刈千賀志, 陳志傑, 鈴木直弘, 千葉敏彦, 武田広誠, 神林潤一, 柴原義博, 中林成一郎, 稲村直樹, 志賀伸之, 大竹祐輔, 鈴木祐輔, 欠畑誠治, 香取幸夫

日本耳鼻咽喉科学会会報　122　(4)　679-679　2019/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
早期喉頭癌に対し行われた経口的腫瘍切除術の治療成績

舘田豊, 渡邊健一, 清水佑一, 橋本光, 白倉真之, 太田淳, 平野愛, 本藏陽平, 鈴木淳, 小川武則, 香取幸夫

日本耳鼻咽喉科学会会報　122　(4)　707-707　2019/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
新しい誤嚥防止手術輪状軟骨を温存した喉頭中央部切除術変法

加藤健吾, 平野愛, 香取幸夫

日本気管食道科学会会報　70　(2)　s5-s5　2019/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
ゴアテックスを使用した甲状軟骨形成術1型の術後合併症

渡邊健一, 平野愛, 本藏陽平, 鹿島和孝, 白倉真之, 香取幸夫

日本気管食道科学会会報　70　(2)　s31-s31　2019/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
舌癌術後の摂食・嚥下障害に対する歯科補綴学的介入の効果-手術内容別の考察-

泉田一賢, 泉田一賢, 小山重人, 小山重人, 佐藤奈央子, 佐藤奈央子, 水戸武彦, 水戸武彦, 平野愛, 加藤健吾, 香取幸夫, 佐々木啓一

日本嚥下医学会抄録(Web)　42nd　2019
スギ舌下免疫療法に関するアンケート調査 1シーズン目、2シーズン目および3シーズン目の比較

太田伸男, 湯田厚司, 小川由起子, 東海林史, 粟田口敏一, 鈴木直弘, 千葉敏彦, 陳志傑, 草刈千賀志, 武田広誠, 神林潤一, 志賀伸之, 大竹祐輔, 鈴木祐輔, 柴原義博, 中林成一郎, 稲村直樹, 長舩大士, 和田弘太, 欠畑誠治, 香取幸夫, 岡本美孝

日本耳鼻咽喉科学会会報　122　(1)　35-44　2019/01
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
耳下腺唾石の治療方針

鈴木貴博, 野口直哉, 東海林史, 角田梨紗子, 太田伸男, 小倉正樹, 香取幸夫

日本耳鼻咽喉科学会会報　122　(1)　45-51　2019/01
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
音程調整を伴う発声における早期の脳活動について―脳磁図を用いた検討―

野村有理, 川瀬哲明, 川瀬哲明, 菅野彰剛, 中里信和, 中里信和, 川島隆太, 香取幸夫

日本ヒト脳機能マッピング学会プログラム・抄録集　21st　93　2019
バイオデザインを用いた医療機器開発の新しい形―超音波透過法を用いた誤嚥検出手法の事業化に向けて―

原陽介, 瀧宏文, 永富良一, 出江紳一, 香取幸夫

電子情報通信学会技術研究報告　118　(383(MICT2018 59-67)(Web))　19 (WEB ONLY)　2019/01

ISSN： 0913-5685
症例をどうみるか咬筋内に発生した静脈性血管瘤の1例

平野愛, 渡邊健一, 香取幸夫

JOHNS　35　(1)　119-122　2019/01
Publisher: (株)東京医学社
ISSN： 0910-6820
Management of parotid sialolithiasis

Takahiro Suzuki, Naoya Noguchi, Fumi Shoji, Risako Kakuta, Nobuo Ohta, Masaki Ogura, Yukio Katori

Journal of Otolaryngology of Japan　122　45-51　2019/01/01

DOI： 10.3950/jibiinkoka.122.45 　

ISSN： 0030-6622
Practical study of sublingual immunotherapy in patients with japanese cedar pollinosis using a questionnaire comparison among the first season, second season and third season

Nobuo Ohta, Atsushi Yuta, Yukiko Ogawa, Fumi Shoji, Toshiichi Awataguchi, Naohiro Suzuki, Toshihiko Chiba, Shiketsu Chin, Chikashi Kusakari, Kousei Takeda, Junichi Kanbayashi, Nobuyuki Shiga, Yusuke Otake, Yusuke Suzuki, Yoshihiro Shibahara, Seiichiro Nakabayashi, Naoki Inamura, Hiroshi Osafune, Kota Wada, Seiji Kakehata, Yukio Katori, Yoshitaka Okamoto

Journal of Otolaryngology of Japan　122　35-44　2019/01/01

DOI： 10.3950/jibiinkoka.122.35 　

ISSN： 0030-6622
Intestinal type adenocarcinoma of nasal cavity^―a case report and literature review^―

Kazuki Nakamura, Takenori Ogawa, Ayako Nakanome, Akira Ohkoshi, Eiichi Ishida, Masahiro Rokugo, Tomohiko Ishikawa, Shun Wakamori, Takuya Yoshida, Yukio Katori

Japanese Journal of Head and Neck Cancer　45　(3)　337-341　2019/01/01
Publisher: Japan Society for Head and Neck Cancer
DOI： 10.5981/jjhnc.45.337 　

ISSN： 1349-5747
バイオデザインを用いた医療機器開発の実際と日本のイノベーションエコシステムにおける事業化の課題

原陽介, 香取幸夫, 瀧宏文, 中川敦寛, 芳賀洋一, 永富良一, 出江紳一

日本摂食・嚥下リハビリテーション学会雑誌　22　(3)　S31-S32　2018/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
【頸部腫瘤を熟知する】頸部腫瘤の診断手順頸部腫瘤を診る細胞診、組織診 CTガイド下のcore needle biopsy

小川武則, 常陸真, 石井亮, 石川智彦, 六郷正博, 中目亜矢子, 石田英一, 大越明, 香取幸夫

JOHNS　34　(12)　1678-1682　2018/12
Publisher: (株)東京医学社
ISSN： 0910-6820
嚥下障害診療の標準化と普及嚥下障害の訓練の標準化摂食嚥下認定言語聴覚士・看護師に対する全国アンケート調査結果より

加藤健吾, 香取幸夫

喉頭　30　(2)　54-54　2018/12
Publisher: 日本喉頭科学会
ISSN： 0915-6127

eISSN： 2185-4696
嚥下訓練法の現状とEBM創出に向けた取り組み

香取幸夫

喉頭　30　(2)　66-66　2018/12
Publisher: 日本喉頭科学会
ISSN： 0915-6127

eISSN： 2185-4696
声門下狭窄症例の気道確保における体外循環ECMOの使用経験

白倉真之, 渡邊健一, 橋本光, 本藏陽平, 石田英一, 野村和弘, 香取幸夫

日本耳鼻咽喉科学会会報　121　(11)　1395-1400　2018/11
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
当院における摂食嚥下機能評価の取り組みについて

逸見朋隆, 小倉正樹, 山崎宗治, 舘田豊, 平野愛, 香取幸夫

仙台市立病院医学雑誌　38　9-13　2018/10
Publisher: 仙台市立病院
ISSN： 0388-8878
嚥下障害の治療間接訓練と手術に関して

香取幸夫

日本耳鼻咽喉科学会会報　121　(10)　1313-1315　2018/10
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
当科の機能性難聴例の検討

高梨芳崇, 鈴木淳, 田畑摩純, 若盛隼, 川瀬哲明, 香取幸夫

磐城共立病院医報　39　(1)　4-11　2018/09
Publisher: いわき市医療センター
ISSN： 0916-3387
トランスサイレチンにおける高値要因の検討

鈴木千恵, 樫尾一志, 横田柚梨菜, 安久美子, 武田卓也, 平泉敦子, 藤巻慎一, 岡本智子, 小野寺晃一, 藤井博司, 元井冬彦, 香取幸夫

日本臨床検査自動化学会会誌　43　(4)　433-433　2018/09
Publisher: (一社)日本臨床検査自動化学会
ISSN： 0286-1607
第一鰓裂由来の形態異常に感染を反復し、手術治療を必要とした小児の1例

草野佑典, 日高浩史, 香取幸夫

日本耳鼻咽喉科感染症・エアロゾル学会会誌　6　(3)　37-37　2018/09
Publisher: 日本耳鼻咽喉科感染症・エアロゾル学会
ISSN： 2188-0077

eISSN： 2434-1932
トランスサイレチンにおける高値要因の検討

鈴木千恵, 樫尾一志, 横田柚梨菜, 安久美子, 武田卓也, 平泉敦子, 藤巻慎一, 岡本智子, 小野寺晃一, 藤井博司, 元井冬彦, 香取幸夫

日本臨床検査自動化学会会誌　43　(4)　433-433　2018/09
Publisher: (一社)日本臨床検査自動化学会
ISSN： 0286-1607
人工中耳医療の未来-The future of middle ear implant- 鎖耳に対する人工中耳手術正円窓アプローチの手技とその適応(The future of middle ear implant Vibrant Soundbridge Implantation via a Retrofacial Approach in a Patient with Congenital Aural Atresia)

日高浩史, 池田怜吉, 宮崎浩充, 香取幸夫, 小林俊光

Otology Japan　28　(4)　227-227　2018/09
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
C57BL/6背景の遺伝子改変マウスを用いた難聴研究のピットホール "Passenger Gene"の問題点について

鈴木淳, 本藏陽平, 川瀬哲明, 香取幸夫

Otology Japan　28　(4)　391-391　2018/09
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
人工内耳埋め込み術が奏功したANCA関連血管炎性中耳炎(OMAAV)の一症例

高井俊輔, 山内大輔, 本藏陽平, 白倉真之, 小林祐太, 日高浩史, 川瀬哲明, 香取幸夫

Otology Japan　28　(4)　396-396　2018/09
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
人工内耳挿入後、MRIにより人工内耳磁石逸脱をきたした神経線維腫症2型の一例

須納瀬知輝, 日高浩史, 白倉真之, 本蔵陽平, 山内大輔, 香取幸夫

Otology Japan　28　(4)　398-398　2018/09
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
耳管開放症患者における鼻声の検討

池田怜吉, 宮崎浩充, 小林俊光, 本蔵陽平, 川瀬哲明, 香取幸夫

Otology Japan　28　(4)　413-413　2018/09
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
転写因子NRF2活性化による加齢性難聴予防効果の検討

本蔵陽平, 大石哲也, 川瀬哲明, 香取幸夫

Otology Japan　28　(4)　503-503　2018/09
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
浸潤型副鼻腔真菌症8例の検討

山形真理, 生島寛享, 渡邊健一, 野村和弘, 香取幸夫

日本鼻科学会会誌　57　(3)　411-411　2018/09
Publisher: (一社)日本鼻科学会
ISSN： 0910-9153

eISSN： 1883-7077
副鼻腔骨髄肉腫(myeloid sarcoma)の一例

鈴木淳, 野村和弘, 菅原充, 香取幸夫

日本鼻科学会会誌　57　(3)　421-421　2018/09
Publisher: (一社)日本鼻科学会
ISSN： 0910-9153

eISSN： 1883-7077
頭蓋底手術を施行した鼻腔原発腸管型腺癌の1例

中村和樹, 香取幸夫

日本鼻科学会会誌　57　(3)　478-478　2018/09
Publisher: (一社)日本鼻科学会
ISSN： 0910-9153

eISSN： 1883-7077
高齢者諸機能低下メカニズムの解明:基礎系・臨床系研究成果の統合的議論

阿部伸一, 香取幸夫, 日向信之, 石田瞭, 大久保真衣, 山本仁, 北村啓, 山本将仁

歯科学報　118　(4)　273‐274-273　2018/08/30
Publisher: 東京歯科大学学会
ISSN： 0037-3710
頭頸部領域に発生したspindle cell carcinomaの5例

高橋ひより, 渡邊健一, 白倉真之, 本藏陽平, 山内大輔, 香取幸夫

耳鼻咽喉科臨床　111　(8)　557-563　2018/08
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0032-6313

eISSN： 1884-4545
嚥下障害への対応Up to Date 頭頸部癌治療にともなう嚥下障害への治療戦略

石井亮, 加藤健吾, 平野愛, 佐藤剛史, 大越明, 小川武則, 松浦一登, 香取幸夫

口腔・咽頭科　31　(3)　238-238　2018/08
Publisher: 日本口腔・咽頭科学会
ISSN： 0917-5105

eISSN： 1884-4316
頭頸部がん治療後における嚥下内視鏡検査の有用性

大越明, 石井亮, 加藤健吾, 香取幸夫

口腔・咽頭科　31　(3)　327-327　2018/08
Publisher: 日本口腔・咽頭科学会
ISSN： 0917-5105

eISSN： 1884-4316
高齢者諸機能低下メカニズムの解明基礎系・臨床系研究成果の統合的議論

阿部伸一, 香取幸夫, 日向信之, 石田瞭, 大久保真衣, 山本仁, 北村啓, 山本将仁

歯科学報　118　(4)　273-273　2018/08
Publisher: 東京歯科大学学会
ISSN： 0037-3710
耳鳴患者に認められる聴覚過敏に関する検討

高梨芳崇, 川瀬哲明, 佐藤剛史, 香取幸夫

Audiology Japan　61　(3)　203-208　2018/06
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
頭頸部癌における高齢者機能評価スクリーニングツールの有用性

石井亮, 小川武則, 高橋昌宏, 嵯峨井俊, 中目亜矢子, 大越明, 東賢二郎, 白倉真之, 香取幸夫

頭頸部外科　28　(1)　55-61　2018/06
Publisher: (NPO)日本頭頸部外科学会
ISSN： 1349-581X

eISSN： 1884-474X
アンケートを用いた舌下免疫療法に関するスギ花粉症患者の実態調査 1から3シーズン目の比較

佐竹雅史, 太田伸男, 湯田厚司, 鈴木直弘, 鈴木祐輔, 柴原義博, 稲村直樹, 角田梨紗子, 東海林史, 香取幸夫, 岡本美孝

耳鼻咽喉科免疫アレルギー　36　(2)　87-87　2018/06
Publisher: 日本耳鼻咽喉科免疫アレルギー学会
ISSN： 0913-0691
耳鼻咽喉科診療up to date 嚥下障害の治療診療科連携、手術、誤嚥の検出と防止への取り組み

香取幸夫, 加藤健吾, 平野愛

耳鼻咽喉科臨床補冊　(補冊153)　50-50　2018/06
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
頭頸部領域に発生したspindle cell carcinomaの5例

高橋ひより, 渡邊健一, 香取幸夫

耳鼻咽喉科臨床補冊　(補冊153)　82-82　2018/06
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
体外循環下に気道確保を行った声門下狭窄症の1例

白倉真之, 渡邊健一, 本藏陽平, 香取幸夫

耳鼻咽喉科臨床補冊　(補冊153)　94-94　2018/06
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
【わかりやすい感覚器疾患】感覚器症候のみかた嗅覚・味覚味覚障害

香取幸夫

日本医師会雑誌　147　(特別1)　S116-S117　2018/06
Publisher: (公社)日本医師会
ISSN： 0021-4493
1歳3ヵ月で手術を行った第一鰓裂由来・鰓性奇形の1例

日高浩史, 白倉真之, 安達美佳, 香取幸夫

小児耳鼻咽喉科　39　(2)　136-136　2018/06
Publisher: 日本小児耳鼻咽喉科学会
ISSN： 0919-5858

eISSN： 2186-5957
アンケートを用いた舌下免疫療法に関するスギ花粉症患者の実態調査 1から3シーズン目の比較

佐竹雅史, 太田伸男, 湯田厚司, 鈴木直弘, 鈴木祐輔, 柴原義博, 稲村直樹, 角田梨紗子, 東海林史, 香取幸夫, 岡本美孝

耳鼻咽喉科免疫アレルギー　36　(2)　87-87　2018/06
Publisher: 日本耳鼻咽喉科免疫アレルギー学会
ISSN： 0913-0691

eISSN： 2185-5900
下歯肉癌手術における下顎骨切除範囲と術後機能の検討

小川武則, 大越明, 石田英一, 石井亮, 石川智彦, 宮下仁, 永井宏和, 佐藤奈央子, 小山重人, 高地崇, 高木尚之, 香取幸夫

頭頸部癌　44　(2)　168-168　2018/05/09
Publisher: (一社)日本頭頸部癌学会
ISSN： 1349-5747
【手術に必要な画像診断-口腔・咽頭編】下歯肉・下顎腫瘍切除術

石田英一, 小川武則, 小嶋郁穂, 大越明, 石井亮, 川村善宜, 石川智彦, 橋本光, 香取幸夫

JOHNS　34　(5)　583-587　2018/05
Publisher: (株)東京医学社
ISSN： 0910-6820
舌癌を除く口腔癌179例の臨床統計

六郷正博, 小川武則, 中目亜矢子, 大越明, 石田英一, 石井亮, 石川智彦, 香取幸夫

頭頸部癌　44　(2)　140-140　2018/05
Publisher: (一社)日本頭頸部癌学会
ISSN： 1349-5747

eISSN： 1881-8382
下歯肉癌手術における下顎骨切除範囲と術後機能の検討

小川武則, 大越明, 石田英一, 石井亮, 石川智彦, 宮下仁, 永井宏和, 佐藤奈央子, 小山重人, 高地崇, 高木尚之, 香取幸夫

頭頸部癌　44　(2)　168-168　2018/05
Publisher: (一社)日本頭頸部癌学会
ISSN： 1349-5747

eISSN： 1881-8382
転写因子NRF2の活性化による加齢性難聴予防効果の検討

本蔵陽平, 大石哲也, 川瀬哲明, 香取幸夫

耳鼻咽喉科ニューロサイエンス　32　38-39　2018/05
Publisher: 耳鼻咽喉科ニューロサイエンス研究会
喉頭乳頭腫診療の全国実態調査

松崎洋海, 吉崎智一, 鈴木幹男, 香取幸夫, 牧山清

日本気管食道科学会会報　69　(2)　s35-s35　2018/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
自己フィブリン糊の使用効果を検証する耳鼻咽喉科領域におけるCryoSeal systemによる完全自家血フィブリン糊の使用経験

山内大輔, 本藏陽平, 渡邊健一, 香取幸夫

日本輸血細胞治療学会誌　64　(2)　238-238　2018/04
Publisher: (一社)日本輸血・細胞治療学会
ISSN： 1881-3011

eISSN： 1883-0625
【患者・家族への説明ガイド-正しく伝え,納得を引き出し,判断を促すために】声とことばのこと (Question 69)こどもがガラガラ声です。治療は必要でしょうか?

香取幸夫

耳鼻咽喉科・頭頸部外科　90　(5)　216-217　2018/04
Publisher: (株)医学書院
ISSN： 0914-3491

eISSN： 1882-1316
【患者・家族への説明ガイド-正しく伝え,納得を引き出し,判断を促すために】声とことばのこと (Question 70)こどものどもりが心配です。治るのでしょうか?

香取幸夫

耳鼻咽喉科・頭頸部外科　90　(5)　218-219　2018/04
Publisher: (株)医学書院
ISSN： 0914-3491

eISSN： 1882-1316
嚥下障害の診断と治療病院勤務医の視点から

香取幸夫

日本耳鼻咽喉科学会会報　121　(4)　435-435　2018/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
顔面神経走行異常を伴った外耳道閉鎖症に対する人工中耳手術症例

日高浩史, 池田怜吉, 宮崎浩充, 小林俊光, 山内大輔, 香取幸夫

日本耳鼻咽喉科学会会報　121　(4)　521-521　2018/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
頭頸部腺様嚢胞癌63例の臨床統計

石田英一, 石井亮, 六郷正博, 東賢二郎, 石川智彦, 佐藤亜矢子, 大越明, 小川武則, 香取幸夫

日本耳鼻咽喉科学会会報　121　(4)　542-542　2018/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
局所進行口腔癌手術における摂食嚥下障害の危険因子の検討

大越明, 石田英一, 小川武則, 中目亜矢子, 石井亮, 加藤健吾, 香取幸夫

日本耳鼻咽喉科学会会報　121　(4)　552-552　2018/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
重力に依存した嚥下運動の数値流体力学シミュレーションの開発

太田淳, 石田駿一, 川瀬哲明, 香取幸夫, 今井陽介

日本耳鼻咽喉科学会会報　121　(4)　569-569　2018/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
生体ヒツジを用いた水中内視鏡下耳科手術トレーニング

山内大輔, 本藏陽平, 原陽介, 大石哲也, 鹿島和孝, 荒川一弥, 日高浩史, 香取幸夫

日本耳鼻咽喉科学会会報　121　(4)　570-570　2018/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
Thiel法固定献体を利用した耳鼻咽喉・頭頸部外科手術の有用性と問題点

小川武則, 山内大輔, 渡邊健一, 加藤健吾, 日高浩史, 川瀬哲明, 菅原充, 松浦一登, 中村一博, 鹿野真人, 岸本誠司, 香取幸夫

日本耳鼻咽喉科学会会報　121　(4)　581-581　2018/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
高齢者機能評価スクリーニングツールG8の治療選択に対する有用性

石井亮, 大越明, 石田英一, 石川智彦, 川村善宣, 小川武則, 香取幸夫

日本耳鼻咽喉科学会会報　121　(4)　589-589　2018/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
鼓室形成術を要した潜在性中耳異物による慢性中耳炎の2症例

須納瀬知輝, 本蔵陽平, 山内大輔, 日高浩史, 川瀬哲明, 香取幸夫

日本耳鼻咽喉科学会会報　121　(4)　594-594　2018/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
両側顎下腺管摘出を行った線維素性唾液管炎の1例

川村善宣, 堀亨, 佐々木高綱, 香取幸夫

日本耳鼻咽喉科学会会報　121　(4)　606-606　2018/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
摂食嚥下認定言語聴覚士・看護師に対する全国アンケート調査

加藤健吾, 香取幸夫, 唐帆健浩, 木村百合香, 熊井良彦, 二藤隆春, 藤本保志, 兵頭政光

日本耳鼻咽喉科学会会報　121　(4)　625-625　2018/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
【レドックス疾患学酸素・窒素・硫黄活性種はどう作用するのか、どこまで健康・疾患と関わるのか?】(第2章)レドックスと疾患内耳の酸化障害とその防御機構

本蔵陽平, 香取幸夫

実験医学　36　(5)　827-830　2018/03
Publisher: (株)羊土社
ISSN： 0288-5514
【頸部腫瘤の診かた】頸部臓器疾患唾液腺腫脹と充実性腫瘤

香取幸夫

小児内科　50　(2)　263-266　2018/02
Publisher: (株)東京医学社
ISSN： 0385-6305
頭頸部原発骨肉腫の6例

嵯峨井俊, 小川武則, 臼渕肇, 小嶋郁穂, 村田隆紀, 阪本真弥, 高橋昌宏, 西條憲, 加藤健吾, 中目亜矢子, 大越明, 東賢二郎, 石井亮, 香取幸夫

頭頸部外科　27　(3)　379-385　2018/02
Publisher: (NPO)日本頭頸部外科学会
ISSN： 1349-581X

eISSN： 1884-474X
舌癌術後の摂食嚥下障害に対する歯科補綴介入の効果

泉田一賢, 小山重人, 佐藤奈央子, 水戸武彦, 石河理紗, 加藤健吾, 香取幸夫, 佐々木啓一

日本摂食嚥下リハビリテーション学会学術大会抄録集(Web)　24th　2018
最大舌圧と舌運動の関連について

平野愛, 加藤健吾, 佐藤剛史, 泉田一賢, 佐藤奈央子, 小山重人, 香取幸夫

日本摂食嚥下リハビリテーション学会学術大会抄録集(Web)　24th　2018
東北大学病院摂食嚥下治療センターにおける摂食嚥下障害の実態調査と歯科的介入の検討

水戸武彦, 小山重人, 泉田一賢, 佐藤奈央子, 石河理紗, 加藤健吾, 香取幸夫, 佐々木啓一

日本摂食嚥下リハビリテーション学会学術大会抄録集(Web)　24th　2018
舌切除に伴う摂食嚥下障害を舌接触補助床により改善した1症例

泉田一賢, 小山重人, 佐藤奈央子, 水戸武彦, 松舘芳樹, 木山朋美, 石河理紗, 加藤健吾, 香取幸夫, 佐々木啓一

日本嚥下医学会抄録(Web)　41st　2018
バイオデザイン手法による研究開発の設計~誤嚥検出デバイスの開発を目指して~

原陽介, 原陽介, 香取幸夫, 瀧宏文, 中川敦寛, 芳賀洋一, 永富良一, 出江紳一

日本嚥下医学会抄録(Web)　41st　2018
NDUFS4欠損マウスにおける顎下腺・副腎の形態異常とステロイド合成障害

小林祐太, 尾形雅君, 尾形雅君, 南都文香, 南都文香, 香川慶輝, 山本由似, 山本由似, 宮崎啓史, 伊藤将人, 香取幸夫, 阿部高明, 大和田祐二

日本解剖学会総会・全国学術集会講演プログラム・抄録集　123rd　133　2018
バイオデザインを用いた医療機器開発の実際と日本のイノベーションエコシステムにおける事業化の課題

原陽介, 香取幸夫, 瀧宏文, 中川敦寛, 芳賀洋一, 永富良一, 出江紳一

日本摂食嚥下リハビリテーション学会学術大会抄録集(Web)　24th　(3)　S31‐S32 (WEB ONLY)-S32　2018
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
症例をどうみるか MRIが診断に有用であった頭頸部悪性腫瘍の2症例

中目亜矢子, 小川武則, 小嶋郁穂, 阪本真弥, 村田隆紀, 臼渕肇, 石井亮, 川村善宜, 大越明, 嵯峨井俊, 香取幸夫

JOHNS　34　(1)　132-137　2018/01
Publisher: (株)東京医学社
ISSN： 0910-6820
【こんなときどうする? 術中・術後のトラブル対応】《咽喉頭・頭頸部領域》乳糜漏が止まらない

小川武則, 大越明, 香取幸夫

耳鼻咽喉科・頭頸部外科　90　(1)　66-69　2018/01
Publisher: (株)医学書院
ISSN： 0914-3491

eISSN： 1882-1316
喉頭形成術がもたらす音声障害患者の心理的側面およびQOLへの効果

平野愛, 渡邊健一, 佐藤剛史, 本蔵陽平, 香取幸夫

音声言語医学　59　(1)　52-52　2018/01
Publisher: 日本音声言語医学会
ISSN： 0030-2813

eISSN： 1884-3646
当院における摂食嚥下機能評価の取り組みについて

逸見朋隆, 小倉正樹, 山崎宗治, 舘田豊, 平野愛, 香取幸夫

音声言語医学　59　(1)　58-58　2018/01
Publisher: 日本音声言語医学会
ISSN： 0030-2813

eISSN： 1884-3646
耳管開放症患者における「鼻声」に関する検討

鈴木陽子, 池田怜吉, 宮崎浩充, 小林俊光, 川瀬哲明, 菊地俊晶, 大島英敏, 佐藤剛史, 本蔵陽平, 香取幸夫

音声言語医学　59　(1)　91-91　2018/01
Publisher: 日本音声言語医学会
ISSN： 0030-2813

eISSN： 1884-3646
音程調整を伴う発声中の脳活動について脳磁図を用いた検討

野村有理, 川瀬哲明, 高梨芳崇, 八幡湖, 中里信和, 香取幸夫

音声言語医学　59　(1)　100-100　2018/01
Publisher: 日本音声言語医学会
ISSN： 0030-2813

eISSN： 1884-3646
Continuation of chylorrhea

Takenori Ogwa, Akira Okoshi, Yukio Katori

Otolaryngology - Head and Neck Surgery (Japan)　90　(1)　66-69　2018/01/01

ISSN： 0914-3491
Five cases of spindle cell carcinoma of the head and neck region

Hiyori Takahashi, Kenichi Watanabe, Masayuki Shirakura, Yohei Honkura, Daisuke Yamauchi, Yukio Katori

Practica Oto-Rhino-Laryngologica　111　(8)　557-563　2018/01/01

DOI： 10.5631/jibirin.111.557 　

ISSN： 0032-6313
Diagnosis and treatment of dysphagia

Yukio Katori

Journal of Otolaryngology of Japan　121　1313-1315　2018/01/01

DOI： 10.3950/jibiinkoka.121.1313 　

ISSN： 0030-6622
Tracheostomy using extracorporeal membrane oxygenation in a patient with subglottic stenosis

Masayuki Shirakura, Kenichi Watanabe, Hikaru Hashimoto, Youhei Honkura, Eiichi Ishida, Kazuhiro Nomura, Yukio Katori

Journal of Otolaryngology of Japan　121　(11)　1395-1400　2018/01/01

DOI： 10.3950/jibiinkoka.121.1395 　

ISSN： 0030-6622
テクニカル・ノート Bath plug closure法を用いた経鼻内視鏡的髄液漏閉鎖術耳鼻科・脳神経外科連携領域の治療

川口奉洋, 荒川一弥, 野村和弘, 小川欣一, 香取幸夫, 冨永悌二

Neurological Surgery　45　(12)　1067-1073　2017/12
Publisher: (株)医学書院
ISSN： 0301-2603

eISSN： 1882-1251
喉頭科学と地域医療地域に出ていく耳鼻咽喉科の嚥下診療

加藤健吾, 香取幸夫

喉頭　29　(2)　45-45　2017/12
Publisher: 日本喉頭科学会
ISSN： 0915-6127

eISSN： 2185-4696
水中内視鏡下耳科手術(UWEES)に使用する灌流液についての検討

山内大輔, 原陽介, 本藏陽平, 日高浩史, 川瀬哲明, 香取幸夫

Equilibrium Research　76　(5)　519-519　2017/10
Publisher: (一社)日本めまい平衡医学会
ISSN： 0385-5716

eISSN： 1882-577X
耳管開放症診断におけるSonotubometry法とTTAG法の意義に関する考察

川瀬哲明, 高田生織, 池田怜吉, 大島英敏, 菊地俊晶, 香取幸夫, 小林俊光

Otology Japan　27　(4)　411-411　2017/10
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
水中内視鏡下操作による経迷路法によって摘出した錐体部真珠腫の3症例

山内大輔, 本蔵陽平, 原陽介, 白倉真之, 日高浩史, 川瀬哲明, 香取幸夫

Otology Japan　27　(4)　474-474　2017/10
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
祖先アデノ随伴ウイルス(AAV2/Anc80L65)を用いた成体マウスに対する蝸牛遺伝子治療法の確立

鈴木淳, 橋本研, 香取幸夫

Otology Japan　27　(4)　478-478　2017/10
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
転写因子NRF2の活性化による酸化ストレスに対する内耳保護効果の解明

本蔵陽平, 大石哲也, 川瀬哲明, 香取幸夫

Otology Japan　27　(4)　550-550　2017/10
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
【頭頸部悪性腫瘍の疑問に答える】治療後の対応放射線治療後の唾液分泌障害や高度嚥下障害に対する対応を教えてください

小川武則, 石井亮, 大越明, 加藤健吾, 嵯峨井俊, 中目亜矢子, 岩崎さや香, 細川亮一, 香取幸夫

JOHNS　33　(9)　1346-1350　2017/09
Publisher: (株)東京医学社
ISSN： 0910-6820
深頸部膿瘍排膿術後に嚥下機能回復が遅延する因子に関する検討

日高浩史, 小澤大樹, 清水祐一, 角田梨紗子, 香取幸夫

日本耳鼻咽喉科感染症・エアロゾル学会会誌　5　(3)　49-49　2017/09
Publisher: 日本耳鼻咽喉科感染症・エアロゾル学会
ISSN： 2188-0077

eISSN： 2434-1932
頭頸部癌化学放射線療法で嚥下障害の出現・遷延化を防ぐために

加藤健吾, 石井亮, 香取幸夫

嚥下医学　6　(2)　231-232　2017/09
Publisher: 日本嚥下医学会
ISSN： 2186-3199
根治的放射線療法後の頭頸部癌患者におけるEAT-10と嚥下機能評価の関連について

佐藤剛史, 加藤健吾, 石井亮, 本藏陽平, 大石哲也, 白倉真之, 小林祐太, 原陽介, 太田淳, 小川武則, 渡邊健一, 香取幸夫

嚥下医学　6　(2)　247-247　2017/09
Publisher: 日本嚥下医学会
ISSN： 2186-3199
頭頸部癌化学放射線療法中の経口摂取中止および嚥下機能の胃瘻依存への影響

石井亮, 加藤健吾, 佐藤剛史, 大石哲也, 本藏陽平, 白倉真之, 小林祐太, 原陽介, 平野愛, 鹿島和孝, 香取幸夫

嚥下医学　6　(2)　248-249　2017/09
Publisher: 日本嚥下医学会
ISSN： 2186-3199
頭頸部癌根治的化学放射線療法における舌根-咽頭後壁間距離の変化と絶食期間、照射後嚥下障害との関係

加藤健吾, 石井亮, 佐藤剛史, 大石哲也, 本藏陽平, 原陽介, 白倉真之, 小林祐太, 鹿島和孝, 平野愛, 香取幸夫

嚥下医学　6　(2)　249-249　2017/09
Publisher: 日本嚥下医学会
ISSN： 2186-3199
食道における腸管神経の分布高齢者のご遺体を用いた免疫組織化学的研究

香取幸夫, 本蔵陽平, 平野愛

嚥下医学　6　(2)　261-261　2017/09
Publisher: 日本嚥下医学会
ISSN： 2186-3199
誤嚥防止を目的とする狭域の喉頭摘出術喉頭中央部切除術

香取幸夫, 平野愛, 加藤健吾

嚥下医学　6　(2)　261-262　2017/09
Publisher: 日本嚥下医学会
ISSN： 2186-3199
食道癌放射線治療後に生じたcarotid blowout syndromeに対する血管内治療症例報告

高橋重文, 川口奉洋, 新妻邦泰, 中川敦寛, 藤村幹, 小川武則, 香取幸夫, 冨永悌二

Neurological Surgery　45　(9)　791-798　2017/09
Publisher: (株)医学書院
ISSN： 0301-2603

eISSN： 1882-1251
声帯麻痺患者に対するトラフェルミン注入術の効果の検討

鹿島和孝, 許斐氏元, 金澤丈治, 倉上和也, 駒澤大吾, 香取幸夫, 渡邊雄介

耳鼻と臨床　63　(5)　194-194　2017/09
Publisher: 耳鼻と臨床会
ISSN： 0447-7227

eISSN： 2185-1034
Underwater techniqueによる残存聴力活用型人工内耳埋め込み術について

山内大輔, 本藏陽平, 原陽介, 野村有理, 八幡湖, 高梨芳崇, 安達美佳, 太田淳, 佐藤剛史, 佐々木志保, 和野紗央里, 日高浩史, 川瀬哲明, 香取幸夫

Audiology Japan　60　(5)　292-292　2017/09
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
耳鳴患者における不快閾値とHQ(Hyperacusis Questionaire)を用いた評価の検討

高梨芳崇, 川瀬哲明, 佐藤剛史, 香取幸夫

Audiology Japan　60　(5)　398-398　2017/09
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
上顎洞真菌症fungal ballに対するendoscopic modified medial maxillectomy(EMMM)の有用性

野村和弘, 荒川一弥, 鈴木淳, 香取幸夫

日本鼻科学会会誌　56　(3)　376-376　2017/09
Publisher: (一社)日本鼻科学会
ISSN： 0910-9153

eISSN： 1883-7077
【耳鼻咽喉科疾患と生活指導-予防とセルフケア】耳鼻咽喉科疾患に対する生活指導・予防・セルフケア嚥下障害、気道・食道異物

香取幸夫

JOHNS　33　(8)　1041-1042　2017/08
Publisher: (株)東京医学社
ISSN： 0910-6820
スギ花粉舌下免疫療法に関するアンケート調査

太田伸男, 湯田厚司, 鈴木直弘, 柴原義博, 稲村直樹, 角田梨紗子, 東海林史, 鈴木祐輔, 香取幸夫, 岡本美孝

耳鼻咽喉科免疫アレルギー　35　(2)　201-202　2017/08
Publisher: 日本耳鼻咽喉科免疫アレルギー学会
ISSN： 0913-0691

eISSN： 2185-5900
【摂食嚥下障害リハビリテーションABC】総論介入嚥下障害に対する手術法とその適応

香取幸夫

MEDICAL REHABILITATION　(212)　151-156　2017/07
Publisher: (株)全日本病院出版会
ISSN： 1346-0773
アンケートを用いた舌下免疫療法に関するスギ花粉症患者の実態調査 1シーズン目と2シーズン目の比較

太田伸男, 湯田厚司, 小川由起子, 東海林史, 粟田口敏一, 鈴木直弘, 千葉敏彦, 陳志傑, 武田広誠, 神林潤一, 志賀伸之, 大竹祐輔, 鈴木祐輔, 柴原義博, 中林成一郎, 稲村直樹, 欠畑誠治, 香取幸夫

日本耳鼻咽喉科学会会報　120　(7)　914-922　2017/07
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
繰り返す誤嚥性肺炎に対して喉頭中央部切除術を施行した筋強直性ジストロフィーの2例

中村里紗, 加藤量広, 成川孝一, 及川崇紀, 宮崎真紀子, 香取幸夫

臨床神経学　57　(6)　355-355　2017/06
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
東北大学病院における喉頭扁平上皮癌の臨床統計

東賢二郎, 小川武則, 石井亮, 中目亜矢子, 渡邊健一, 香取幸夫

耳鼻咽喉科展望　60　(補冊1)　20-21　2017/06
Publisher: 耳鼻咽喉科展望会
ISSN： 0386-9687

eISSN： 1883-6429
東北大学における若年者舌癌の治療の検討

石井亮, 小川武則, 白倉真之, 東賢二郎, 大越明, 嵯峨井俊, 香取幸夫

耳鼻咽喉科展望　60　(補冊1)　42-43　2017/06
Publisher: 耳鼻咽喉科展望会
ISSN： 0386-9687

eISSN： 1883-6429
疾患・難聴の予防と治療基礎研究の最前線転写因子NRF2の抗酸化作用による内耳保護効果の解明

本蔵陽平, 川瀬哲明, 香取幸夫, 本橋ほづみ

日本抗加齢医学会総会プログラム・抄録集　17回　97-97　2017/06
Publisher: (一社)日本抗加齢医学会
【外来から帰してはいけない患者-症状からみた対応と病院に送るタイミング】耳鼻咽喉科救急および重症患者の紹介診療録ならびに紹介状記載の留意点

香取幸夫

JOHNS　33　(5)　553-554　2017/05
Publisher: (株)東京医学社
ISSN： 0910-6820
【外来から帰してはいけない患者-症状からみた対応と病院に送るタイミング】症状からみた対応と病院に送るタイミング嚥下障害

香取幸夫

JOHNS　33　(5)　609-610　2017/05
Publisher: (株)東京医学社
ISSN： 0910-6820
急性中耳炎、ならびに鼻副鼻腔炎が関与していると考えられた硬膜外膿瘍の1例

日高浩史, 角田梨紗子, 小澤大樹, 入間田美保子, 矢野寿一, 香取幸夫

小児耳鼻咽喉科　38　(2)　99-99　2017/05
Publisher: 日本小児耳鼻咽喉科学会
ISSN： 0919-5858

eISSN： 2186-5957
小児閉塞性睡眠時無呼吸に対する簡易睡眠時呼吸モニター検査検査結果の解析条件による変化

安達美佳, 日高浩史, 三木未佳, 新谷香織, 香取幸夫

小児耳鼻咽喉科　38　(2)　172-172　2017/05
Publisher: 日本小児耳鼻咽喉科学会
ISSN： 0919-5858

eISSN： 2186-5957
ミトコンドリアを標的とした新規化合物MA-5の内耳保護効果の検討

本蔵陽平, 荒川一弥, 池田怜吉, 川瀬哲明, 香取幸夫

耳鼻咽喉科ニューロサイエンス　31　35-36　2017/05
Publisher: 耳鼻咽喉科ニューロサイエンス研究会
耳下腺および副咽頭間隙腫瘍をはじめとする頭頸部腫瘍に対するcore needle biopsyの有用性

石井亮, 小川武則, 臼渕肇, 白倉真之, 東賢二郎, 中目亜矢子, 大越明, 嵯峨井俊, 香取幸夫

頭頸部癌　43　(2)　188-188　2017/05
Publisher: (一社)日本頭頸部癌学会
ISSN： 1349-5747

eISSN： 1881-8382
当科における下咽頭食道重複癌の検討

東賢二郎, 小川武則, 嵯峨井俊, 中目亜矢子, 大越明, 石井亮, 香取幸夫

頭頸部癌　43　(2)　274-274　2017/05
Publisher: (一社)日本頭頸部癌学会
ISSN： 1349-5747

eISSN： 1881-8382
摂食嚥下リハビリテーションupdate 診断・評価から治療・ケアまで嚥下障害の手術治療

香取幸夫

The Japanese Journal of Rehabilitation Medicine　54　(特別号)　SY13-2　2017/05
Publisher: (公社)日本リハビリテーション医学会
ISSN： 1881-3526

eISSN： 1881-8560
【臨床力UP! 耳鼻咽喉科検査マニュアル】声の検査聴覚印象評価

香取幸夫

耳鼻咽喉科・頭頸部外科　89　(5)　350-353　2017/04
Publisher: (株)医学書院
ISSN： 0914-3491

eISSN： 1882-1316
反回神経麻痺の診断と治療声帯麻痺患者に対するトラフェルミン注入術の効果の検討

鹿島和孝, 許斐氏元, 金澤丈治, 倉上和也, 駒澤大吾, 香取幸夫, 渡邊雄介

日本気管食道科学会会報　68　(2)　192-192　2017/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
嚥下障害診療

香取幸夫

日本耳鼻咽喉科学会会報　120　(4)　440-441　2017/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
深頸部膿瘍排膿術後に嚥下機能回復が遅延する因子に関する検討(第2報)

日高浩史, 小澤大樹, 平野愛, 渡邊健一, 香取幸夫

日本耳鼻咽喉科学会会報　120　(4)　581-581　2017/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
耳下腺唾石症例の検討

鈴木貴博, 東海林史, 角田梨紗子, 野口直哉, 太田伸男, 小倉正樹, 香取幸夫

日本耳鼻咽喉科学会会報　120　(4)　582-582　2017/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
長尺状の医療器具の保持機構を備えた水中耳科手術用内視鏡システムの開発

山内大輔, 松永忠雄, 本藏陽平, 原陽介, 荒川一弥, 日高浩史, 川瀬哲明, 芳賀洋一, 香取幸夫

日本耳鼻咽喉科学会会報　120　(4)　587-587　2017/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
誤嚥防止術としての喉頭中央部分切除術の有効性の検証

加藤健吾, 平野愛, 逸見朋隆, 渡邉幸二郎, 小倉正樹, 本藏陽平, 石井亮, 大石哲也, 香取幸夫

日本耳鼻咽喉科学会会報　120　(4)　608-608　2017/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
彎曲型咽喉頭直達鏡を用いた下咽頭病変の観察および治療の有用性について

渡邊健一, 山内大輔, 高梨芳崇, 石井亮, 白倉真之, 澤田朱里, 渡来剛右, 清水佑一, 日高浩史, 香取幸夫

日本耳鼻咽喉科学会会報　120　(4)　621-621　2017/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
アンケートを用いた舌下免疫療法に関するスギ花粉症患者の実態調査

太田伸男, 湯田厚司, 小川由紀子, 東海林史, 粟田口敏一, 鈴木直弘, 千葉敏彦, 陳志傑, 武田広誠, 神林潤一, 志賀伸之, 大竹祐輔, 鈴木祐輔, 柴原義博, 中林成一郎, 稲村直樹, 欠畑誠治, 香取幸夫, 岡本美孝

日本耳鼻咽喉科学会会報　120　(4)　630-630　2017/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
経鼓室的に開窓した側頭下窩コレステリン肉芽腫例

原陽介, 山内大輔, 日高浩史, 澤田朱里, 渡邊健一, 川瀬哲明, 香取幸夫

耳鼻咽喉科臨床　110　(4)　245-250　2017/04
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0032-6313

eISSN： 1884-4545
人工内耳挿入補助機構を備えた水中耳科手術用内視鏡

松永忠雄, 秋山恭一, 山内大輔, 川瀬哲明, 香取幸夫, 鶴岡典子, 芳賀洋一

日本コンピュータ外科学会誌　19　(2)　74-82　2017/04
Publisher: (一社)日本コンピュータ外科学会
ISSN： 1344-9486

eISSN： 1884-5770
唾液腺造影で分節性嚢胞状拡張を呈した反復性耳下腺腫脹の1例

川村善宣, 高梨芳崇, 香取幸夫

口腔・咽頭科　30　(1)　103-109　2017/03
Publisher: 日本口腔・咽頭科学会
ISSN： 0917-5105

eISSN： 1884-4316
MRIで悪性腫瘍箇所を同定し得た耳下腺多形腺腫由来癌の1例

若盛隼, 小川武則, 臼渕肇, 阪本真弥, 小嶋郁穂, 村田隆紀, 嵯峨井俊, 中目亜矢子, 大越明, 東賢二郎, 石井亮, 白倉真之, 石川智彦, 香取幸夫

頭頸部外科　26　(3)　389-393　2017/02
Publisher: (NPO)日本頭頸部外科学会
ISSN： 1349-581X

eISSN： 1884-474X
【頭頸部癌学-診断と治療の最新研究動向-】頭頸部癌の疫学我が国における頭頸部癌の疫学的動向

小川武則, 嵯峨井俊, 中目亜矢子, 大越明, 香取幸夫

日本臨床　75　(増刊2 頭頸部癌学)　47-52　2017/02
Publisher: (株)日本臨床社
ISSN： 0047-1852
Duchenne型筋ジストロフィー患者の嚥下機能評価

平野愛, 小林祐太, 太田淳, 平野愛, 小林祐太, 太田淳, 大村悠, 由利博美, 武田篤, 香取幸夫

日本摂食嚥下リハビリテーション学会学術大会抄録集(Web)　23rd　2017
顎二腹筋再建による喉頭挙上術

大越明, 小川武則, 嵯峨井俊, 中目亜矢子, 東賢二郎, 石井亮, 香取幸夫

日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集　27th　2017
東北大学における頭頚部再建症例への当院摂食嚥下センターの介入

高木尚之, 高地崇, 庄司未樹, 村木健二, 館正弘, 加藤健吾, 小川武則, 香取幸夫

日本形成外科学会総会・学術集会プログラム・抄録集　60th　371　2017
上半規管裂隙症候群の4手術例―耳管開放症との鑑別点と手術法について

池田怜吉, 小林俊光, 山内大輔, 川瀬哲明, 川瀬哲明, 香取幸夫

日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集　27th　177　2017
第1鰓溝性瘻孔の一例

小林祐太, 山内大輔, 渡邊健一, 清水佑一, 中目亜矢子, 小川武則, 香取幸夫

日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集　27th　113　2017
Present state and future prospect of Japan biodesign fellowship program in Tohoku university

原陽介, 中川敦寛, 香取幸夫, 出江紳一, 永富良一, 瀧宏文, 川村文彦

Transactions of Japanese Society for Medical and Biological Engineering　55　(3)　165-165　2017
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.55Annual.165 　

ISSN： 1347-443X

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<p>Japan biodesign program is the Japanese version of Stanford biodesign, which is an education program to develop leader of medical device innovation. The characteristics of the program is an approach that they start from clinical observation, extract a well-characterized need, and create concepts. On the other hand, because we have only two years' experiences, we need to discuss how to apply the method based on American medical system to Japan and how to use it in the Japanese ecosystem. I am engaged in the second budge (2016-17) of Japan biodesign fellowship. I think that not only we can learn systematized knowledge related to medical device development, but also we can create needs and concepts which are useful for business implementation in a short term. In this presentation, I will introduce the contents and progress of our fellowship activities and discuss the present state and future prospect of the program.</p>
音声障害症例に関するHADSを用いた心理的評価に影響する要因についての検討

佐藤剛史, 渡邊健一, 本蔵陽平, 太田淳, 平野愛, 小林祐太, 香取幸夫

音声言語医学　58　(1)　74-74　2017/01
Publisher: 日本音声言語医学会
ISSN： 0030-2813

eISSN： 1884-3646
声帯萎縮症における吸入ステロイド薬使用例の検討

渡邊健一, 本蔵陽平, 平野愛, 太田淳, 小林祐太, 佐藤剛史, 香取幸夫

音声言語医学　58　(1)　87-88　2017/01
Publisher: 日本音声言語医学会
ISSN： 0030-2813

eISSN： 1884-3646
外来患者の栄養補助・支援を目的とした「栄養支援ステーション」の開設実践報告

前田晋平, 菅野直子, 奥山祐, 岡本智子, 稲村なお子, 元井冬彦, 香取幸夫, 海野倫明

日本静脈経腸栄養学会雑誌　32　(Suppl.)　757-757　2017/01
Publisher: (株)ジェフコーポレーション
ISSN： 2189-0161

eISSN： 2189-017X
A case of cholesterol granuloma extending to the infratemporal fossa treated by transtympanic fenestration of the cyst

Yosuke Hara, Daisuke Yamauchi, Hiroshi Hidaka, Kenichi Watanabe, Yukio Katori, Akari Sawada, Tetsuaki Kawase

Practica Oto-Rhino-Laryngologica　110　(4)　245-250　2017
Publisher: Society of Practical Otolaryngology
DOI： 10.5631/jibirin.110.245 　

ISSN： 0032-6313
A study on seventy-eight cases of parotid tumor

Takahiro Suzuki, Hiroyuki Ikushima, Risako Kakuta, Naoya Noguchi, Masaki Ogura, Takenori Ogawa, Yukio Katori, Fumi Shoji, Nobuo Ohta

Practica Oto-Rhino-Laryngologica　110　(4)　295-302　2017
Publisher: Society of Practical Otolaryngology
DOI： 10.5631/jibirin.110.295 　

ISSN： 0032-6313
Practical study of sublingual immunotherapy for patients with Japanese cedar pollinosis using a questionnaire: Comparison between the First Season and Second Season

Nobuo Ohta, Atsushi Yuta, Yukiko Ogawa, Fumi Shoji, Toshiichi Awataguchi, Naohiro Suzuki, Toshihiko Chiba, Shiketsu Chin, Kousei Takeda, Junichi Kanbayashi, Nobuyuki Shiga, Yusuke Otake, Yusuke Suzuki, Yoshihiro Shibahara, Seiichiro Nakabayashi, Naoki Inamura, Seiji Kakehata, Yukio Katori

Journal of Otolaryngology of Japan　120　(7)　914-922　2017
Publisher: Oto-Rhino-Laryngological Society of Japan Inc.
DOI： 10.3950/jibiinkoka.120.914 　

ISSN： 0030-6622
Treatment strategy for sinonasal malignant tumor with skull base invasion

Takenori Ogawa, Ikuho Kojima, Takaki Murata, Maya Sakamoto, Keita Kishida, Noriyoshi Takahashi, Haruo Matsushita, Kazuya Arakawa, Kazuhiro Nomura, Ayako Nakanome, Akira Okoshi, Kenjiro Higashi, Ryo Ishii, Shun Sagai, Keiichi Jingu, Yukio Katori

Japanese Journal of Head and Neck Cancer　43　(4)　409-414　2017

DOI： 10.5981/jjhnc.43.409 　

ISSN： 1349-5747

eISSN： 1881-8382
A study on seventy-eight cases of parotid tumor

Takahiro Suzuki, Hiroyuki Ikushima, Risako Kakuta, Naoya Noguchi, Masaki Ogura, Takenori Ogawa, Yukio Katori, Fumi Shoji, Nobuo Ohta

Practica Otologica, Supplement　151　94-96　2017
Publisher: Society of Practical Otolaryngology
DOI： 10.5631/jibirinsuppl.151.94 　

ISSN： 0912-1870
義歯破損を契機に摂食嚥下障害を発症した高齢者に対し、多診療科・多職種アプローチで軽快した一症例

小林祐太, 加藤健吾, 石河理紗, 岩崎さや香, 古澤義人, 佐藤剛史, 小山重人, 香取幸夫

日本摂食・嚥下リハビリテーション学会雑誌　20　(3)　S116-S116　2016/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
東北大学病院における摂食嚥下治療センターの取り組みと摂食・嚥下障害の実態調査

石河理紗, 小山重人, 佐藤奈央子, 細川亮一, 松井裕之, 松舘芳樹, 加藤健吾, 香取幸夫, 小関健由, 佐々木啓一

みちのく歯学会雑誌　47　(1-2)　44-46　2016/12
Publisher: 東北地区歯科医学会
ISSN： 0385-0099
深頸部膿瘍・降下性縦隔炎罹患後の重度嚥下障害頸部のマッサージと舌骨・喉頭の他動運動が著効を奏した1例

佐藤豊展, 加藤健吾, 平野愛, 近藤健男, 柴本勇, 香取幸夫, 出江紳一

日本摂食・嚥下リハビリテーション学会雑誌　20　(3)　156-162　2016/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
食道癌・咽頭癌に関連する感染性仮性総頸動脈破裂の一治療例

新妻邦泰, 川口奉洋, 佐々木貴史, 藤村幹, 小川武則, 香取幸夫, 松本康史, 冨永悌二

脳血管内治療　1　(Suppl.)　S208-S208　2016/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
嚥下障害の診断と治療

香取幸夫

日本耳鼻咽喉科学会会報　119　(10)　1324-1327　2016/10
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
深頸部膿瘍における小児例と成人例の差異に関する検討

清水佑一, 日高浩史, 小澤大樹, 角田梨紗子, 矢野寿一, 香取幸夫

日本耳鼻咽喉科感染症・エアロゾル学会会誌　4　(3)　62-62　2016/09
Publisher: 日本耳鼻咽喉科感染症・エアロゾル学会
ISSN： 2188-0077

eISSN： 2434-1932
鼻咽腔閉鎖不全を伴う嚥下障害に対して頸部突出嚥下により経口摂取が可能となった症例

加藤健吾, 浅田行紀, 鈴木あい, 松浦一登, 香取幸夫

嚥下医学　5　(2)　273-273　2016/09
Publisher: 日本嚥下医学会
ISSN： 2186-3199
東北大学病院における医科歯科合同の摂食嚥下治療センター開設の取り組み

鹿島和孝, 加藤健吾, 平野愛, 太田淳, 石井亮, 渡邊健一, 佐藤剛史, 石河理紗, 松井裕之, 佐藤奈央子, 松舘芳樹, 古澤義人, 伊藤恵美, 細川亮一, 小山重人, 香取幸夫, 上月正博, 出江紳一

嚥下医学　5　(2)　299-299　2016/09
Publisher: 日本嚥下医学会
ISSN： 2186-3199
音声障害患者における心理的要因の関連についての検討

佐藤剛史, 渡邊健一, 高梨芳崇, 本蔵陽平, 平野愛, 太田淳, 川瀬哲明, 香取幸夫

言語聴覚研究　13　(3)　147-147　2016/09
Publisher: (一社)日本言語聴覚士協会
ISSN： 1349-5828
耳鳴患者におけるABR振幅の検討

高梨芳崇, 川瀬哲明, 佐藤剛史, 香取幸夫

Audiology Japan　59　(5)　377-378　2016/09
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
当科の耳鳴診療における言語聴覚士の介入前後の検討

佐藤剛史, 高梨芳崇, 八幡湖, 川瀬哲明, 香取幸夫

Audiology Japan　59　(5)　403-404　2016/09
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
Underwater techniqueによる人工内耳埋め込み術におけるインピーダンスの検討

山内大輔, 原陽介, 八幡湖, 高梨芳崇, 安達美佳, 太田淳, 佐々木志保, 和野紗央里, 日高浩史, 川瀬哲明, 香取幸夫

Audiology Japan　59　(5)　421-422　2016/09
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
人工内耳挿入補助機構を備えた水中耳科手術用内視鏡の開発について

山内大輔, 松永忠雄, 原陽介, 橋本研, 太田淳, 日高浩史, 川瀬哲明, 芳賀洋一, 香取幸夫

Otology Japan　26　(4)　308-308　2016/09
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
水中内視鏡下耳科手術における内視鏡光源による温度上昇の抑制効果について

原陽介, 山内大輔, 本蔵陽平, 日高浩史, 川瀬哲明, 香取幸夫

Otology Japan　26　(4)　470-470　2016/09
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
【頸部腫瘤を見極める】リンパ管腫・ガマ腫

香取幸夫

耳鼻咽喉科・頭頸部外科　88　(9)　670-674　2016/08
Publisher: (株)医学書院
ISSN： 0914-3491

eISSN： 1882-1316
【知っておきたい!高齢者の摂食嚥下障害-基本・管理・診療-】高齢摂食嚥下障害患者と口腔ケア

加藤健吾, 香取幸夫

ENTONI　(196)　51-54　2016/08
Publisher: (株)全日本病院出版会
ISSN： 1346-2067
口蓋扁桃原発濾胞樹状細胞肉腫の1例

白倉真之, 香取幸夫

口腔・咽頭科　29　(3)　384-384　2016/08
Publisher: 日本口腔・咽頭科学会
ISSN： 0917-5105

eISSN： 1884-4316
Treatment of cervical cystic regions - Lymphangioma and Ranula

Yukio Katori

Otolaryngology - Head and Neck Surgery (Japan)　88　670-674　2016/08/01

ISSN： 0914-3491
東北大学病院における摂食・嚥下センターの取り組みと摂食・嚥下障害の実態調査

石河理紗, 小山重人, 加藤健吾, 香取幸夫, 佐々木啓一

日本補綴歯科学会誌　8　(特別号)　127-127　2016/07
Publisher: (公社)日本補綴歯科学会
ISSN： 1883-4426

eISSN： 1883-6860
頭頸部癌適応放射線治療の適応確立に向けた基礎研究: 外部放射線治療期間中の肉眼的腫瘍体積変化と臨床因子間の関連調査 Invited

武田賢, 松下晴雄, 土橋卓, 角谷倫之, 小川武則, 小森慎也, 石澤儀樹, 香取幸夫, 神宮啓一

JASTRO NEWSLETTER　2　(120)　24-26　2016/06
側頭下窩コレステリン肉芽腫の1症例

原陽介, 山内大輔, 日高浩史, 澤田朱里, 渡邊健一, 川瀬哲明, 香取幸夫

耳鼻咽喉科臨床補冊　(補冊146)　67-67　2016/06
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
東北大学における手術手技研修の現況

香取幸夫, 小川武則

耳鼻咽喉科臨床補冊　(補冊146)　69-69　2016/06
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
嗅神経芽細胞腫の臨床検討

白倉真之, 小川武則, 中目亜矢子, 大越明, 香取幸夫

耳鼻咽喉科臨床補冊　(補冊146)　70-70　2016/06
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
喉頭粘表皮癌の1例

澤田朱里, 渡邊健一, 山内大輔, 原陽介, 香取幸夫

耳鼻咽喉科臨床補冊　(補冊146)　80-80　2016/06
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
タブレット端末を用いた在宅での聞き取り訓練の効果について

佐藤剛史, 川瀬哲明, 高梨芳崇, 香取幸夫

耳鼻咽喉科臨床補冊　(補冊146)　102-102　2016/06
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
オルガネラトキシコロジー NRF2依存性環境ストレス応答内耳酸化ストレス障害の軽減に対するNRF2の貢献

本蔵陽平, 松尾洋孝, 村上昌平, 崎山真幸, 水足邦雄, 塩谷彰浩, 山本雅之, 森田一郎, 四ノ宮成祥, 川瀬哲明, 香取幸夫, 本橋ほづみ

The Journal of Toxicological Sciences　41　(Suppl.)　S90-S90　2016/06
Publisher: (一社)日本毒性学会
ISSN： 0388-1350

eISSN： 1880-3989
小児深頸部膿瘍における成人例の違いに関する検討

日高浩史, 小澤大樹, 平野愛, 野村有理, 野口直哉, 角田梨紗子, 矢野寿一, 香取幸夫

小児耳鼻咽喉科　37　(2)　151-151　2016/05
Publisher: 日本小児耳鼻咽喉科学会
ISSN： 0919-5858

eISSN： 2186-5957
T1T2舌扁平上皮癌155例の厚さの検討

舘田勝, 小川武則, 松浦一登, 加藤健吾, 浅田行紀, 西條茂, 香取幸夫, 橋本省

頭頸部癌　42　(2)　164-164　2016/05
Publisher: (一社)日本頭頸部癌学会
ISSN： 1349-5747

eISSN： 1881-8382
咽頭癌化学放射線療法における絶食期間および胃瘻離脱困難の検討

石井亮, 白倉真之, 平野愛, 鹿島和孝, 東賢二郎, 大越明, 中目亜矢子, 嵯峨井俊, 加藤健吾, 小川武則, 香取幸夫

頭頸部癌　42　(2)　183-183　2016/05
Publisher: (一社)日本頭頸部癌学会
ISSN： 1349-5747

eISSN： 1881-8382
EP-1043: Clinical and volumetric prognostic factors in external beam radiotherapy for head and neck cancer Peer-reviewed

K. Takeda, H. Matsushita, T. Ogawa, S. Dobashi, Y. Ishizawa, K. Chida, N. Kadoya, K. Ito, M. Chiba, M. Kubozono, R. Umezawa, Y. Shirata, Y. Ishikawa, T. Yamamoto, M. Kozumi, T. Tanabe, N. Takahashi, Y. Katagiri, S. Tazaka, K. Takeda, K. Sato, Y. Katori, K. Jingu

Radiotherapy and Oncology　119　(1)　S504-S505　2016/04
Publisher: Elsevier BV
DOI： 10.1016/s0167-8140(16)32293-9 　

ISSN： 0167-8140
【嚥下障害の完全マスター】嚥下機能評価

香取幸夫

耳鼻咽喉科・頭頸部外科　88　(4)　283-290　2016/04
Publisher: (株)医学書院
ISSN： 0914-3491

eISSN： 1882-1316
【耳鼻咽喉科とメディカルスタッフ】摂食嚥下障害診療とメディカルスタッフ

香取幸夫

JOHNS　32　(4)　488-490　2016/04
Publisher: (株)東京医学社
ISSN： 0910-6820
気管食道科から次世代リーダーを育成するご遺体を用いた頭頸部手術手技研修と研究

香取幸夫, 小川武則, 本蔵陽平, 平野愛

日本気管食道科学会会報　67　(2)　90-92　2016/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
口腔・咽頭癌治療症例に対する簡易嚥下誘発検査

香取幸夫, 加藤健吾, 渡邊健一, 石井亮, 平野愛, 荒川一弥, 太田淳, 中目亜矢子, 小川武則

日本気管食道科学会会報　67　(2)　s2-s2　2016/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
下咽頭・食道重複癌に対する治療強度と忍容性

石井亮, 小川武則, 嵯峨井俊, 大越明, 東賢二郎, 香取幸夫

日本気管食道科学会会報　67　(2)　s22-s22　2016/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
筋ジストロフィー患者に対する嚥下スクリーニング検査の有用性の検討

平野愛, 渡邊健一, 香取幸夫

日本気管食道科学会会報　67　(2)　s73-s73　2016/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
広い視野と学識を備えた耳鼻咽喉科医師の育成を目指す

香取幸夫

日本耳鼻咽喉科学会会報　119　(4)　457-458　2016/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
水中内視鏡下耳科手術(UWEES;Under Water Endoscopic Ear Surgery)にて摘出した錐体部真珠腫

山内大輔, 原陽介, 村上朱里, 太田淳, 日高浩史, 川瀬哲明, 香取幸夫

日本耳鼻咽喉科学会会報　119　(4)　556-556　2016/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
男女共同参画(第2報) 常勤医継続とイクボス

菊地俊晶, 香取幸夫

日本耳鼻咽喉科学会会報　119　(4)　559-559　2016/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
7価結合型肺炎球菌ワクチン導入後に本邦の小児急性中耳炎症例から分離された肺炎球菌の分子疫学的解析

小澤大樹, 矢野寿一, 日高浩史, 沖津尚弘, 角田梨紗子, 香取幸夫

日本耳鼻咽喉科学会会報　119　(4)　569-569　2016/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
壊死性降下性縦隔炎に対する排膿術後の嚥下障害併発に関する検討

日高浩史, 小澤大樹, 平野愛, 角田梨紗子, 菅野景子, 嵯峨井俊, 渡邊健一, 香取幸夫

日本耳鼻咽喉科学会会報　119　(4)　570-570　2016/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
側頭骨疾患に対する、3D手術シミュレーターを用いたトレーニングの有用性

原陽介, 山内大輔, 日高浩史, 村上朱里, 太田淳, 渡邊健一, 川瀬哲明, 香取幸夫

日本耳鼻咽喉科学会会報　119　(4)　570-570　2016/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
ヤギ頸部標本を用いた喉頭手術トレーニング

加藤健吾, 山内大輔, 原陽介, 鹿島和孝, 渡邊健一, 香取幸夫

日本耳鼻咽喉科学会会報　119　(4)　571-571　2016/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
NRF2活性化による強大音曝露に伴う酸化ストレスからの内耳保護効果 Nrf2遺伝子欠損マウス解析

本蔵陽平, 水足邦雄, 塩谷彰浩, 川瀬哲明, 香取幸夫, 本橋ほづみ

日本耳鼻咽喉科学会会報　119　(4)　611-611　2016/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
NRF2活性化による強大音曝露に伴う酸化ストレスからの内耳保護効果 50歳聴力への影響

水足邦雄, 本蔵陽平, 川瀬哲明, 香取幸夫, 本橋ほづみ, 塩谷彰浩

日本耳鼻咽喉科学会会報　119　(4)　611-611　2016/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
感音難聴耳の最高語音明瞭度に与える要因に関する検討

八幡湖, 川瀬哲明, 高梨芳崇, 佐藤剛史, 宮崎浩充, 山内大輔, 野村和弘, 香取幸夫

日本耳鼻咽喉科学会会報　119　(4)　616-616　2016/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
【耳鼻咽喉科処方マニュアル】麻痺・痛み・異常感咽喉頭酸逆流症

香取幸夫

耳鼻咽喉科・頭頸部外科　88　(5)　277-280　2016/04
Publisher: (株)医学書院
ISSN： 0914-3491

eISSN： 1882-1316
症例をどうみるか拍動性鼓膜を呈した特発性側頭骨髄膜脳瘤症例

山内大輔, 日高浩史, 川瀬哲明, 香取幸夫

JOHNS　32　(4)　529-534　2016/04
Publisher: (株)東京医学社
ISSN： 0910-6820
東北大学病院における喉頭癌T2症例の検討

山本貴也, 松下晴雄, 菅原俊幸, 久保園正樹, 梅澤玲, 角谷倫之, 石川陽二郎, 古積麻衣子, 高橋紀善, 伊藤謙吾, 片桐佑, 武田賢, 土橋卓, 神宮啓一, 小川武則, 香取幸夫

Japanese Journal of Radiology　34　(Suppl.)　5-5　2016/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
超高齢者に対して喉頭全摘術を施行した2症例

石井亮, 小川武則, 加藤健吾, 中目亜矢子, 東賢二郎, 嵯峨井俊, 渡邊健一, 香取幸夫

頭頸部外科　25　(3)　319-323　2016/02
Publisher: (NPO)日本頭頸部外科学会
ISSN： 1349-581X

eISSN： 1884-474X
70歳以上の舌悪性腫瘍120例の臨床検討 70歳未満252例との比較

舘田勝, 小川武則, 松浦一登, 加藤健吾, 浅田行紀, 西條茂, 香取幸夫, 橋本省

頭頸部外科　25　(3)　389-394　2016/02
Publisher: (NPO)日本頭頸部外科学会
ISSN： 1349-581X

eISSN： 1884-474X
チーム医療におけるコミュニケーションツールとしてのコーチングの有用性

岡本智子, 稲村なお子, 太田正孝, 久道周彦, 酒井敬子, 元井冬彦, 香取幸夫

日本静脈経腸栄養学会雑誌　31　(1)　263-263　2016/01
Publisher: (株)ジェフコーポレーション
ISSN： 2189-0161

eISSN： 2189-017X
褥瘡に対する栄養補助食品の治癒促進効果を検討する多職種共同前向き臨床研究モデルの立ち上げ

有明恭平, 元井冬彦, 岡本智子, 稲村なお子, 中川圭, 水間正道, 石田晶玄, 青木修一, 香取幸夫, 海野倫明

日本静脈経腸栄養学会雑誌　31　(1)　416-416　2016/01
Publisher: (株)ジェフコーポレーション
ISSN： 2189-0161

eISSN： 2189-017X
音声障害症例に関するHADSを用いた心理的評価の検討

佐藤剛史, 高梨芳崇, 渡邊健一, 本蔵陽平, 平野愛, 太田淳, 川瀬哲明, 香取幸夫

音声言語医学　57　(1)　103-104　2016/01
Publisher: 日本音声言語医学会
ISSN： 0030-2813

eISSN： 1884-3646
小児の気管切開術の留意点

香取幸夫

日本耳鼻咽喉科学会会報　118　(12)　1470-1471　2015/12
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
NRF2活性化による、強大音曝露に伴う酸化ストレスからの内耳保護効果の解明

本蔵陽平, 村上昌平, 山本雅之, 川瀬哲明, 香取幸夫, 本橋ほづみ

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　88回・38回　[3P1212]-[3P1212]　2015/12
Publisher: (公社)日本生化学会
北海道・東北12施設における顎下腺癌の臨床統計

鈴木貴博, 小川武則, 加藤健吾, 石田英一, 小澤大樹, 鈴木淳, 小林俊光, 香取幸夫

耳鼻咽喉科展望　58　(補冊1)　22-23　2015/09
Publisher: 耳鼻咽喉科展望会
ISSN： 0386-9687

eISSN： 1883-6429
東北大学における原発不明癌の検討

東賢二郎, 小川武則, 加藤健吾, 中目亜矢子, 石井亮, 香取幸夫

耳鼻咽喉科展望　58　(補冊1)　42-43　2015/09
Publisher: 耳鼻咽喉科展望会
ISSN： 0386-9687

eISSN： 1883-6429
Campylobacter rectusが原因と考えられた急性中耳炎の一例

角田梨紗子, 日高浩史, 矢野寿一, 小澤大樹, 香取幸夫

日本耳鼻咽喉科感染症・エアロゾル学会会誌　3　(3)　34-34　2015/09
Publisher: 日本耳鼻咽喉科感染症・エアロゾル学会
ISSN： 2188-0077

eISSN： 2434-1932
急性中耳炎、ならびに副鼻腔炎が関与していると考えられた硬膜外膿瘍の1例

日高浩史, 角田梨紗子, 小澤大樹, 入間田美保子, 矢野寿一, 香取幸夫

日本耳鼻咽喉科感染症・エアロゾル学会会誌　3　(3)　51-51　2015/09
Publisher: 日本耳鼻咽喉科感染症・エアロゾル学会
ISSN： 2188-0077

eISSN： 2434-1932
水中内視鏡下に閉鎖術を施行した半規管瘻孔症例の聴力評価

山内大輔, 太田淳, 奥村有理, 日高浩史, 川瀬哲明, 香取幸夫, 山崎宗治, 川村善宣, 佐々木高綱

Audiology Japan　58　(5)　329-330　2015/09
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
一側性の高度難聴を来たしたマントル細胞リンパ腫による髄膜癌腫症例自験例4症例との比較を含めて

菅野景子, 日高浩史, 奥村有理, 荒川一弥, 角田梨紗子, 高橋薫, 宮崎浩充, 山内大輔, 川瀬哲明, 香取幸夫

Audiology Japan　58　(5)　345-346　2015/09
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
当科における補聴器を用いたTRTの検討

高梨芳崇, 川瀬哲明, 佐藤剛史, 織田一葉, 香取幸夫

Audiology Japan　58　(5)　481-482　2015/09
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
聴性誘発脳磁界に観察されるlip-reading効果の「時間窓」

川瀬哲明, 八幡湖, 高梨芳崇, 坂本修一, 中里信和, 香取幸夫

Audiology Japan　58　(5)　501-502　2015/09
Publisher: (一社)日本聴覚医学会
DOI： 10.4295/audiology.58.501 　

ISSN： 0303-8106

eISSN： 1883-7301
深頸部膿瘍後の重度嚥下障害に舌骨喉頭のマッサージと他動運動が有効と考えられた一例

佐藤豊展, 加藤健吾, 香取幸夫, 河本愛, 石井亮, 近藤健男, 出江紳一

嚥下医学　4　(2)　268-268　2015/09
Publisher: 日本嚥下医学会
ISSN： 2186-3199
側頭骨の類骨骨腫(osteoid osteoma)、並びに骨芽細胞腫(osteoblastoma)に関するシステマテックレビュー

日高浩史, 山内大輔, 野村和弘, 渡邊健一, 川瀬哲明, 香取幸夫

Otology Japan　25　(4)　608-608　2015/09
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
水中内視鏡下に閉塞術を施行した上半規管裂隙症候群の1例

山内大輔, 川瀬哲明, 野村有理, 高梨芳崇, 日高浩史, 香取幸夫

Otology Japan　25　(4)　715-715　2015/09
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
小児滲出性中耳炎診療ガイドラインアルゴリズムへの「鼻すすり」追記提言 6歳症例提示

菊地俊晶, 池田怜吉, 大島英敏, 香取幸夫

Otology Japan　25　(4)　739-739　2015/09
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
Endoscopic modified medial maxillectomyによる上顎洞外病変への低侵襲アプローチ

荒川一弥, 小澤大樹, 野村和弘, 山内大輔, 渡邊健一, 香取幸夫

日本鼻科学会会誌　54　(3)　361-361　2015/09
Publisher: (一社)日本鼻科学会
ISSN： 0910-9153

eISSN： 1883-7077
硬口蓋に浸潤した上顎洞角化嚢胞性歯原性腫瘍に対するアプローチ

野村和弘, 荒川一弥, 香取幸夫, 吉田尚弘

日本鼻科学会会誌　54　(3)　397-397　2015/09
Publisher: (一社)日本鼻科学会
ISSN： 0910-9153

eISSN： 1883-7077
特徴的な唾液腺造影所見がみられた反復性耳下腺腫脹の1例

川村善宣, 高梨芳崇, 香取幸夫

口腔・咽頭科　28　(3)　359-359　2015/08
Publisher: 日本口腔・咽頭科学会
ISSN： 0917-5105

eISSN： 1884-4316
誤嚥防止手術

香取幸夫

耳鼻咽喉科臨床　108　(7)　501-505　2015/07
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0032-6313

eISSN： 1884-4545
Surgical treatment for prevention for aspiration

Yukio Katori

Practica Oto-Rhino-Laryngologica　108　(7)　501-505　2015/07/01
Publisher: Society of Practical Otolaryngology
DOI： 10.5631/jibirin.108.501 　

ISSN： 0032-6313
【顔面神経とその周辺-最近の進歩とトピックス】診断のトピックスアブミ骨筋反射陽性の顔面神経麻痺への対応

日高浩史, 鈴木貴博, 石井亮, 中目亜矢子, 小川武則, 香取幸夫

JOHNS　31　(6)　698-702　2015/06
Publisher: (株)東京医学社
ISSN： 0910-6820
【日常診療に必要な口腔ケアの知識】摂食嚥下障害と口腔ケア

香取幸夫

日本医師会雑誌　144　(3)　496-499　2015/06
Publisher: (公社)日本医師会
ISSN： 0021-4493
頭蓋底手術を施行した悪性末梢神経鞘腫の1例

中目亜矢子, 小川武則, 浅田行紀, 香取幸夫

耳鼻咽喉科臨床補冊　(補冊142)　88-88　2015/06
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
下顎再建用チタンプレートと甲状軟骨間を短縮する喉頭挙上術を実施した2症例

河本愛, 中目亜矢子, 小川武則, 香取幸夫

耳鼻咽喉科臨床補冊　(補冊142)　97-97　2015/06
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
顎関節と中耳腔の交通に起因すると考えられた開閉口に伴う他覚性耳鳴の1症例

日高浩史, 本蔵陽平, 山内大輔, 川瀬哲明, 香取幸夫, 小倉正樹, 湯浅有, 小林俊光

耳鼻咽喉科臨床補冊　(補冊142)　99-99　2015/06
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
全身麻酔手術後にCO2ナルコーシスをきたし、肥満低換気症候群が判明した1例

安達美佳, 渡邊健一, 吉崎直人, 香取幸夫

耳鼻咽喉科臨床補冊　(補冊142)　156-156　2015/06
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
【注意すべき真菌症診療の落とし穴】部位別真菌症診療の実際咽喉頭

香取幸夫

耳鼻咽喉科・頭頸部外科　87　(6)　406-408　2015/05
Publisher: (株)医学書院
ISSN： 0914-3491

eISSN： 1882-1316
頸部郭清術後の内頸静脈閉塞についての検討

石井亮, 小川武則, 中目亜矢子, 東賢二郎, 嵯峨井俊, 野村和弘, 香取幸夫

頭頸部癌　41　(2)　227-227　2015/05
Publisher: (一社)日本頭頸部癌学会
ISSN： 1349-5747

eISSN： 1881-8382
【新生児聴覚スクリーニング後の療育体制の問題点】宮城県の小児難聴に対する医療、療育の現状と問題点について

高梨芳崇, 川瀬哲明, 沖津卓二, 八幡湖, 奥村有理, 佐々木志保, 宮崎浩充, 香取幸夫

Audiology Japan　58　(2)　136-142　2015/04
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
扁平上皮癌を合併した鼻副鼻腔乳頭腫症例

橋本研, 菊地俊晶, 宮崎真紀子, 野村和弘, 沖津尚弘, 香取幸夫

日本耳鼻咽喉科学会会報　118　(4)　486-486　2015/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
遠隔転移を来した唾液腺多型腺腫の3例

嵯峨井俊, 小川武則, 中目亜矢子, 東賢二郎, 石井亮, 臼渕肇, 渡邊健一, 香取幸夫

日本耳鼻咽喉科学会会報　118　(4)　491-491　2015/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
喉頭蓋基部を牽引し下顎骨に固定する低侵襲な喉頭挙上術の検討

河本愛, 本藏陽平, 高梨芳崇, 渡邊健一, 小倉正樹, 香取幸夫

日本耳鼻咽喉科学会会報　118　(4)　503-503　2015/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
東北大学における有蹄類の頭部標本を用いた内視鏡下耳科手術トレーニング

山内大輔, 奥村友理, 荒川一弥, 宮崎浩充, 日高浩史, 川瀬哲明, 香取幸夫

日本耳鼻咽喉科学会会報　118　(4)　514-514　2015/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
当科における小児機能性難聴例の検討

高梨芳崇, 川瀬哲明, 八幡湖, 奥村有理, 香取幸夫

日本耳鼻咽喉科学会会報　118　(4)　522-522　2015/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
視覚情報提示による聴覚誘発磁界の変化視覚情報提示のタイミングの影響について

川瀬哲明, 高田志穂, 八幡湖, 高梨芳崇, 奥村有理, 菅野彰剛, 中里信和, 川島隆太, 香取幸夫

日本耳鼻咽喉科学会会報　118　(4)　564-564　2015/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
頭頸部非扁平上皮癌におけるEGFR発現

東賢二郎, 小川武則, 中目亜矢子, 石井亮, 香取幸夫

日本耳鼻咽喉科学会会報　118　(4)　564-564　2015/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
側頭骨の類骨骨種(osteoid osteoma)、ならびに骨芽細胞腫(osteoblastoma)に関するシステマテックレビュー

日高浩史, 甲斐谷徹彰, 山内大輔, 野村和弘, 渡邊健一, 川瀬哲明, 香取幸夫

日本耳鼻咽喉科学会会報　118　(4)　572-572　2015/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
咽頭食道重複がん治療における嚥下機能

小川武則, 中目亜矢子, 嵯峨井俊, 東賢二郎, 石井亮, 河本愛, 荒川一弥, 加藤健吾, 香取幸夫

日本耳鼻咽喉科学会会報　118　(4)　574-574　2015/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
遠隔転移を来した頭蓋底浸潤エナメル上皮腫の1例

中目亜矢子, 小川武則, 臼渕肇, 石井亮, 東賢二郎, 嵯峨井俊, 香取幸夫

日本耳鼻咽喉科学会会報　118　(4)　594-594　2015/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
宮城県における新生児聴覚スクリーニングの現状について

奥村有理, 川瀬哲明, 沖津卓二, 高梨芳崇, 八幡湖, 宮崎浩充, 香取幸夫

日本耳鼻咽喉科学会会報　118　(4)　611-611　2015/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
症例をどうみるか喉頭蓋転移をきたした腎細胞癌症例

渡邊健一, 香取幸夫

JOHNS　31　(4)　535-538　2015/04
Publisher: (株)東京医学社
ISSN： 0910-6820
深頸部・縦隔膿瘍治療後の嚥下障害に対し、リハビリテーションが有効であった1症例

河本愛, 石井亮, 渡邊健一, 日高浩史, 香取幸夫

日本気管食道科学会会報　66　(2)　s75-s75　2015/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
Systematic reviewとmeta-analysisからみた糖尿病が深頸部膿瘍に与える影響

日高浩史, 長谷川純, 小澤大樹, 角田理紗子, 河本愛, 香取幸夫

日本気管食道科学会会報　66　(2)　s84-s84　2015/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
手術手技私が愛用する手術器具小児挿管用喉頭鏡を用いた乳児舌根部へのアプローチ

香取幸夫

JOHNS　31　(3)　385-387　2015/03
Publisher: (株)東京医学社
ISSN： 0910-6820
Endoscopic modified medial maxillectomyによる上顎洞外病変への低侵襲アプローチ

荒川一弥, 小澤大樹, 野村和弘, 山内大輔, 渡邊健一, 香取幸夫

日本鼻科学会会誌(Web)　54　(3)　361(J-STAGE)　2015

ISSN： 1883-7077
視聴覚統合処理における脳磁場解析

八幡湖, 川瀬哲明, 坂本修一, 中里信和, 香取幸夫

音声言語医学　56　(1)　99-99　2015/01
Publisher: 日本音声言語医学会
ISSN： 0030-2813

eISSN： 1884-3646
敗血症性肺塞栓症を生じた咀嚼筋間隙膿瘍例

堀亨, 森田真吉, 池田怜吉, 鈴木淳, 矢野寿一, 舘田勝, 香取幸夫

日本耳鼻咽喉科感染症・エアロゾル学会会誌　3　(1)　43-45　2015/01
Publisher: 日本耳鼻咽喉科感染症・エアロゾル学会
ISSN： 2188-0077

eISSN： 2434-1932
栄養ケアプロセスを用いた、栄養の問題点・NST介入内容と成果の明確化

布田美貴子, 稲村なお子, 安藤芙美, 廣田衛久, 小暮高之, 志賀永嗣, 阿部ますえ, 横枕史, 岡本智子, 元井冬彦, 香取幸夫

日本静脈経腸栄養学会雑誌　30　(1)　484-484　2015/01
Publisher: (株)ジェフコーポレーション
ISSN： 2189-0161

eISSN： 2189-017X
中耳および喉頭の関節における弾性線維

香取幸夫

Proceedings of Clinical Electron Microscopy　33　1-4　2015/01
Publisher: 東北臨床超微形態懇話会世話人会
Mycosis in pharynx and larynx

Yukio Katori

Otolaryngology - Head and Neck Surgery (Japan)　87　406-409　2015/01/01

ISSN： 0914-3491
Clinical Factors Relating to Cervical Body Volume Reduction during Curative External Beam Radiation Therapy for Head and Neck Cancer Peer-reviewed

Takeda K, Dobashi S, Komori S, Chida K, Kadoya N, Kida S, Ito K, Sugawara T, Kubozono M, Umezawa R, Ishikawa Y, Yamamoto T, Kozumi M, Takahashi N, Katagiri Y, Onozato Y, Kanai T, Sato K, Kishi K, Matsushita H, Ogawa T, Katori Y, Jingu K

J Nucl Med Radiat Ther　(6)　203　2014/12
ANCA関連血管炎性中耳炎(OMAAV)7症例の検討

菊地俊晶, 奥村有理, 角田梨紗子, 香取幸夫

Otology Japan　24　(5)　766-772　2014/12
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
嚥下障害の手術

香取幸夫

東北医学雑誌　126　(2)　151-152　2014/12
Publisher: 東北医学会
ISSN： 0040-8700
【耳鼻咽喉科とウイルス】急性中耳炎とウイルス

角田梨紗子, 矢野寿一, 小澤大樹, 日高浩史, 香取幸夫

JOHNS　30　(11)　1601-1604　2014/11
Publisher: (株)東京医学社
ISSN： 0910-6820
宮城県の小児難聴に対する医療、療育の現状と問題点について

高梨芳崇, 川瀬哲明, 沖津卓二, 八幡湖, 奥村有理, 宮崎浩充, 香取幸夫

Audiology Japan　57　(5)　515-516　2014/10
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
視覚情報提示による聴覚誘発磁界の変化

八幡湖, 川瀬哲明, 坂本修一, 中里信和, 香取幸夫

Audiology Japan　57　(5)　537-538　2014/10
Publisher: (一社)日本聴覚医学会
DOI： 10.4295/audiology.57.537 　

ISSN： 0303-8106

eISSN： 1883-7301
顎関節と中耳腔の交通に起因すると考えられた開閉口にともなう他覚性耳鳴の1症例

日高浩史, 本蔵陽平, 山内大輔, 川瀬哲明, 香取幸夫, 小林俊光, 小倉正樹, 湯浅有

Audiology Japan　57　(5)　615-616　2014/10
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
Systematic reviewとmeta-analysisからみた糖尿病が深頸部膿瘍に与える影響細菌学的観点から

日高浩史, 矢野寿一, 小澤大樹, 角田梨紗子, 香取幸夫

日本耳鼻咽喉科感染症・エアロゾル学会会誌　2　(3)　26-26　2014/09
Publisher: 日本耳鼻咽喉科感染症・エアロゾル学会
ISSN： 2188-0077

eISSN： 2434-1932
敗血症肺塞栓を生じた咀嚼筋間隙膿瘍の症例

堀亨, 森田真吉, 池田怜二, 鈴木淳, 舘田勝, 橋本省, 香取幸夫

日本耳鼻咽喉科感染症・エアロゾル学会会誌　2　(3)　49-49　2014/09
Publisher: 日本耳鼻咽喉科感染症・エアロゾル学会
ISSN： 2188-0077

eISSN： 2434-1932
嚥下手術私の術式(series 06) 種々の誤嚥防止手術

河本愛, 香取幸夫, 紫野正人, 安岡義人, 金沢英哲

嚥下医学　3　(2)　215-228　2014/09
Publisher: 日本嚥下医学会
ISSN： 2186-3199
下咽頭喉頭頸部食道摘出後の高度狭窄に対し、内視鏡下バルーン拡張術が有用であった1例

小川武則, 加藤健吾, 高田雄介, 東賢二郎, 香取幸夫

嚥下医学　3　(2)　298-299　2014/09
Publisher: 日本嚥下医学会
ISSN： 2186-3199
重度嚥下障害に対して喉頭中央部切除術を行った17例

河本愛, 渡邊健一, 香取幸夫

嚥下医学　3　(2)　316-316　2014/09
Publisher: 日本嚥下医学会
ISSN： 2186-3199
舌電気刺激誘発脳磁界反応を用いた鼓索神経障害評価の可能性に関する検討

高梨芳崇, 川瀬哲明, 菅野彰剛, 八幡湖, 奥村有理, 山内大輔, 中里信和, 川島隆太, 香取幸夫

Otology Japan　24　(4)　407-407　2014/09
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
耳管開放症患者のBMIの検討

菊地俊晶, 高田生織, 大島英敏, 大島猛史, 山内大輔, 小林俊光, 香取幸夫

Otology Japan　24　(4)　466-466　2014/09
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
First Bite syndromeを契機として発見された側頭骨osteoid osteomaの一例

日高浩史, 山内大輔, 野村和弘, 渡邊健一, 川瀬哲明, 香取幸夫

Otology Japan　24　(4)　554-554　2014/09
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
弛緩部型中耳真珠腫における開放耳管の合併率

大島英敏, 小林俊光, 池田怜吉, 菊地俊晶, 大島猛史, 香取幸夫

Otology Japan　24　(4)　569-569　2014/09
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
水中内視鏡下に人工内耳を挿入した蝸牛瘻孔の1例

山内大輔, 日高浩史, 石井亮, 奥村有理, 角田梨紗子, 野村和弘, 宮崎浩充, 川瀬哲明, 香取幸夫, 大島猛史, 小林俊光

Otology Japan　24　(4)　649-649　2014/09
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
蝸牛瘻孔を認めた先天性錐体尖真珠腫の一症例

高田雄介, 山内大輔, 石井亮, 鈴木淳, 川瀬哲明, 香取幸夫

Otology Japan　24　(4)　701-701　2014/09
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
当科における経外耳道的内視鏡下耳科手術(TEES)の現状について

山崎宗治, 山内大輔, 奥村有理, 角田梨紗子, 野村和弘, 宮崎浩充, 日高浩史, 香取幸夫

Otology Japan　24　(4)　708-708　2014/09
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
喉頭気管分離術により長期集中治療からの離脱が可能となった特発性喉頭麻痺の1例

宮川乃理子, 瀬尾亮太, 野村亮介, 入野田崇, 久志本成樹, 香取幸夫

日本救急医学会雑誌　25　(8)　579-579　2014/08
Publisher: (一社)日本救急医学会
ISSN： 0915-924X

eISSN： 1883-3772
副咽頭間隙に迷入した医原性針異物の1例

日高浩史, 鈴木貴博, 橋本省, 香取幸夫

耳鼻咽喉科臨床補冊　(補冊139)　63-63　2014/06
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
喉頭蓋基部を牽引する低侵襲な喉頭挙上術の検討

河本愛, 小倉正樹, 香取幸夫

耳鼻咽喉科臨床補冊　(補冊139)　65-65　2014/06
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
水中内視鏡下に確認した小児先天性真珠腫、上半規管瘻孔の1例

山内大輔, 大島英敏, 高田雄介, 宮崎浩充, 日高浩史, 大島猛史, 川瀬哲明, 香取幸夫

耳鼻咽喉科臨床補冊　(補冊139)　67-67　2014/06
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
Nasal glial heterotopiaの1症例

中目亜矢子, 大島猛史, 香取幸夫

耳鼻咽喉科臨床補冊　(補冊139)　119-119　2014/06
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
先天性難聴の遺伝子診断における臨床検討

宮崎浩充, 織田一葉, 高梨芳崇, 川瀬哲明, 香取幸夫, 宇佐美真一

耳鼻咽喉科臨床補冊　(補冊139)　126-126　2014/06
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
内頸動脈系から栄養される上顎癌の治療戦略

小川武則, 村田隆紀, 中目亜矢子, 東賢二郎, 石井亮, 加藤健吾, 渡邊健一, 香取幸夫

頭頸部癌　40　(2)　172-172　2014/05
Publisher: (一社)日本頭頸部癌学会
ISSN： 1349-5747

eISSN： 1881-8382
頭頸部癌患者に対する化学療法施行時のB型肝炎スクリーニングおよび肝機能の評価

中目亜矢子, 小川武則, 加藤健吾, 渡邊健一, 東賢二郎, 石井亮, 香取幸夫

頭頸部癌　40　(2)　182-182　2014/05
Publisher: (一社)日本頭頸部癌学会
ISSN： 1349-5747

eISSN： 1881-8382
下咽頭癌・食道癌の異時性重複癌に対し、両側下咽頭部分切除、ELPSを施行した一例

石井亮, 小川武則, 渡邊健一, 中目亜矢子, 東賢二郎, 加藤健吾, 志賀清人, 香取幸夫

頭頸部癌　40　(2)　197-197　2014/05
Publisher: (一社)日本頭頸部癌学会
ISSN： 1349-5747

eISSN： 1881-8382
内耳瘻孔に対する水中内視鏡下耳科手術(UWEES;Under Water Endoscopic Ear Surgery)

山内大輔, 山崎宗治, 太田淳, 門脇誠一, 加藤健吾, 香取幸夫

日本耳鼻咽喉科学会会報　117　(4)　438-438　2014/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
片側声帯麻痺の手術治療例における静脈麻酔と全身麻酔実施例の検討

河本愛, 本蔵陽平, 野口直哉, 鈴木貴博, 小倉正樹, 中目亜矢子, 沖津尚弘, 佐々木高綱, 香取幸夫

日本耳鼻咽喉科学会会報　117　(4)　477-477　2014/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
喫煙抽出物暴露頭頸部癌細胞における抗がん剤耐性、浸潤能獲得経路の解析

小川武則, 石田英一, 中目亜矢子, 東賢二郎, 奥村有理, 加藤健吾, 日高浩, 大島猛史, 川瀬哲明, 香取幸夫

日本耳鼻咽喉科学会会報　117　(4)　529-529　2014/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
頸部超音波検査が有用であった頸動脈解離の一例

高橋薫, 石田英一, 宮崎浩充, 渡部由紀子, 日高浩史, 香取幸夫

日本耳鼻咽喉科学会会報　117　(4)　533-533　2014/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
東日本大震災被災地での耳科疾患の検討(続報)

長谷川純, 橋本研, 舘田豊, 奥村有理, 日高浩史, 小林俊光, 香取幸夫

日本耳鼻咽喉科学会会報　117　(4)　538-538　2014/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
耳鼻咽喉科医が担う聴神経腫瘍へのアプローチ

高田雄介, 鈴木淳, 山内大輔, 大島猛史, 川瀬哲明, 香取幸夫

日本耳鼻咽喉科学会会報　117　(4)　547-547　2014/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
狭窄二分内耳道の2例

高梨芳崇, 宮崎浩充, 織田一葉, 八幡湖, 川瀬哲明, 香取幸夫

日本耳鼻咽喉科学会会報　117　(4)　551-551　2014/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
頬部皮下に発生した悪性腫瘍3例の治療経験

鈴木貴博, 石田英一, 小川武則, 加藤健吾, 野村和弘, 奥村有理, 小澤大樹, 菊地俊晶, 香取幸夫

日本耳鼻咽喉科学会会報　117　(4)　572-572　2014/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
嚥下障害を来した舌骨骨折の1例

門脇誠一, 加藤健吾, 山内大輔, 堀亨, 清川裕道, 香取幸夫

日本耳鼻咽喉科学会会報　117　(4)　574-574　2014/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
気道異物の入院加療期間を左右する因子について

日高浩史, 香取幸夫, 小林俊光

日本耳鼻咽喉科学会会報　117　(4)　601-601　2014/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
輪状咽頭筋切断を併せて行う誤嚥防止手術重度嚥下障害を呈する進行性神経疾患に対する喉頭中央部切除術

香取幸夫, 河本愛, 野口直哉, 小倉正樹

日本気管食道科学会会報　65　(2)　s46-s46　2014/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
脳深部刺激術後に長期経過で悪化した嚥下障害に対し喉頭気管分離術が有効であった2症例

安藤肇史, 仁村太郎, 永松謙一, 冨永悌二, 香取幸夫

臨床神経学　54　(3)　246-246　2014/03
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
【気道確保!!】輪状甲状膜切開の実際と留意点

香取幸夫, 橋本省

JOHNS　29　(10)　1733-1737　2013/10
Publisher: (株)東京医学社
ISSN： 0910-6820
頭頸部の稀な部位に発生した神経鞘腫画像と病理の対比

石井清, 長沼廣, 津田雅志, 渋谷恵理, 小倉正樹, 香取幸夫

仙台市立病院医学雑誌　33　13-19　2013/07
Publisher: 仙台市立病院
ISSN： 0388-8878
診断治療難渋症例・重篤合併症への対応策気道異物の入院加療期間を左右する因子について

日高浩史, 小林俊光, 香取幸夫

日本気管食道科学会会報　64　(2)　155-155　2013/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
披裂部粘膜の軟弱化により吸気時喘鳴を呈した1症例

香取幸夫, 河本愛, 高梨芳崇, 本蔵陽平, 小倉正樹, 鈴木貴博, 小林俊光

日本気管食道科学会会報　64　(2)　s17-s17　2013/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
幼児の声門下に生じ、減量切除を行った若年性黄色肉芽腫の1症例

河本愛, 石井景子, 本蔵陽平, 小倉正樹, 香取幸夫, 鈴木貴博, 高梨芳崇, 小林俊光

日本気管食道科学会会報　64　(2)　s82-s82　2013/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
副鼻腔炎根本術後の上顎・篩骨洞に発生したコレステリン肉芽腫の1例

本蔵陽平, 香取幸夫, 河本愛, 小倉正樹, 小林俊光

日本耳鼻咽喉科学会会報　116　(4)　485-485　2013/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
耳管に発生した過誤腫の1症例

河本愛, 香取幸夫, 本蔵陽平, 小倉正樹, 小林俊光

日本耳鼻咽喉科学会会報　116　(4)　529-529　2013/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
重度嚥下障害に対して手術治療を行った44症例の検討

香取幸夫, 河本愛, 本蔵陽平, 小倉正樹, 渡邊健一, 高梨芳崇, 小林俊光

日本耳鼻咽喉科学会会報　116　(4)　553-553　2013/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
1年間に経験した頸部結核3例

河本愛, 小倉正樹, 香取幸夫

耳鼻咽喉科臨床　106　(3)　273-277　2013/03
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0032-6313

eISSN： 1884-4545
Three cases of tuberculosis in the neck

Ai Kawamoto, Masaki Ogura, Yukio Katori

Practica Oto-Rhino-Laryngologica　106　(3)　273-277　2013

DOI： 10.5631/jibirin.106.273 　

ISSN： 0032-6313
気道異物の入院加療期間を左右する因子について

日高浩史, 香取幸夫, 小林俊光

小児耳鼻咽喉科　33　(2)　186-186　2012/06
Publisher: 日本小児耳鼻咽喉科学会
ISSN： 0919-5858

eISSN： 2186-5957
フライドチキンによる気道異物の1症例

日高浩史, 小林俊光, 香取幸夫

日本気管食道科学会会報　63　(2)　s74-s74　2012/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
早期声門癌の経口手術例の検討とNBI観察を併用した声帯切除手術

香取幸夫, 東賢二郎, 小倉正樹, 角田梨紗子, 河本愛, 渡邊健一, 小川武則, 志賀清人, 小林俊光

日本気管食道科学会会報　63　(2)　s80-s80　2012/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
喉頭蓋嚢胞の穿破が有効であった、妊娠8ヵ月の喉頭蓋炎症例

本蔵陽平, 香取幸夫, 河本愛, 小倉正樹

日本耳鼻咽喉科学会会報　115　(4)　451-451　2012/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
重度誤嚥に対して喉頭中央部切除術を施行した2症例

香取幸夫, 小倉正樹, 東賢二郎, 堀容子, 角田梨沙子, 高梨芳崇, 小林俊光

嚥下医学　1　(1)　184-190　2012/02
Publisher: 日本嚥下医学会
ISSN： 2186-3199
切開排膿術を施行した小児頸部リンパ節膿瘍の7症例

東賢二郎, 香取幸夫

小児耳鼻咽喉科　32　(2)　139-139　2011/05
Publisher: 日本小児耳鼻咽喉科学会
ISSN： 0919-5858

eISSN： 2186-5957
フライドチキンによる気道異物の1症例

日高浩史, 鈴木貴博, 清川裕道, 原陽介, 小林俊光, 香取幸夫

小児耳鼻咽喉科　32　(2)　147-147　2011/05
Publisher: 日本小児耳鼻咽喉科学会
ISSN： 0919-5858

eISSN： 2186-5957
手術治療を要した乳児の喉頭蓋嚢腫の3症例

香取幸夫, 小倉正樹, 堀容子, 角田梨沙子, 東賢二郎

小児耳鼻咽喉科　32　(2)　154-154　2011/05
Publisher: 日本小児耳鼻咽喉科学会
ISSN： 0919-5858

eISSN： 2186-5957
誤嚥防止を目的とする低侵襲な喉頭摘出術

香取幸夫, 小倉正樹, 堀容子, 東賢二郎

日本耳鼻咽喉科学会会報　114　(4)　339-339　2011/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
上顎洞エナメル上皮腫の2例

石井清, 田村亮, 堀容子, 香取幸夫, 長沼廣, 渋谷里絵

Japanese Journal of Radiology　29　(Suppl.I)　8-8　2011/01
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
口腔・中咽頭癌外科治療後の摂食・嚥下リハビリテーションによる口腔運動機能とQOLへの効果

小野二美, 上月正博, 志賀清人, 長坂誠, 海老原覚, 香取幸夫, 小林俊光

日本摂食・嚥下リハビリテーション学会雑誌　14　(3)　600-600　2010/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
【お母さんへの回答マニュアル耳鼻咽喉科Q&A 2010】気管・食道編ピーナッツがのどに詰まって死ぬことがあると聞きましたが、本当でしょうか?

香取幸夫

JOHNS　26　(9)　1510-1511　2010/09
Publisher: (株)東京医学社
ISSN： 0910-6820
頭頸部癌治療後の摂食嚥下リハビリテーションが摂食嚥下機能とQOLに及ぼす効果

小野二美, 上月正博, 森信芳, 長坂誠, 海老原覚, 伊藤修, 黒澤一, 志賀清人, 香取幸夫, 小林俊充

The Japanese Journal of Rehabilitation Medicine　47　(9)　652-652　2010/09
Publisher: (公社)日本リハビリテーション医学会
ISSN： 1881-3526

eISSN： 1881-8560
The effect of postoperative swallowing rehabilitation on swallowing function and QOL in patients with head and neck cancer

ONO Kazumi, KOHZUKI Masahiro, SHIGA Kiyoto, NAGASAKA Makoto, KATORI Yukio, EBIHARA Satoru, ITO Osamu, KOBAYASHI Toshimitsu

Toukeibu Gan　36　(1)　111-118　2010/04/25
Publisher: Japan Society for Head and Neck Cancer
DOI： 10.5981/jjhnc.36.111 　

ISSN： 1349-5747
頭頸部癌治療後の摂食嚥下リハビリテーションが摂食嚥下機能とQOLに及ぼす効果

小野二美, 上月正博, 志賀清人, 長坂誠, 香取幸夫, 海老原覚, 伊藤修, 小林俊光

頭頸部癌　36　(1)　111-118　2010/04
Publisher: (一社)日本頭頸部癌学会
ISSN： 1349-5747

eISSN： 1881-8382
口腔・中咽頭癌周術期における摂食機能とQOLの検討縦断調査より

小野二美, 上月正博, 志賀清人, 長坂誠, 香取幸夫, 小林俊光

日本摂食・嚥下リハビリテーション学会雑誌　13　(3)　462-462　2009/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
TS-1の継続投与が有効であった喉頭癌頸椎転移の一例

角田梨紗子, 香取幸夫, 千葉敏彦, 朴澤孝治, 志賀清人, 小林俊光

頭頸部癌　35　(2)　194-194　2009/05
Publisher: (一社)日本頭頸部癌学会
ISSN： 1349-5747

eISSN： 1881-8382
東北大学病院における最近5年間の気道異物25症例の検討

香取幸夫, 高橋悦, 川瀬哲明, 小林俊光

日本気管食道科学会会報　60　(2)　161-161　2009/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
頸部食道癌の治療における化学放射線併用療法の有用性について

志賀清人, 小川武則, 香取幸夫, 片桐克則, 牧敦子, 小林俊光

日本気管食道科学会会報　60　(2)　194-195　2009/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
MRI発声同期撮像法による/t/・/k/・/s/生成時の声道形状の検討

佐々木具文, 伊藤秀美, 小坂井秀行, 中原寛子, 香取幸夫, 今泉敏, 森川秀広

音声言語医学　50　(1)　39-39　2009/01
Publisher: 日本音声言語医学会
ISSN： 0030-2813

eISSN： 1884-3646
電気的パラトグラフィによる慢性期Dysarthria患者の構音に関する検討

小坂井秀行, 伊藤秀美, 佐々木具文, 香取幸夫, 中原寛子

音声言語医学　50　(1)　84-84　2009/01
Publisher: 日本音声言語医学会
ISSN： 0030-2813

eISSN： 1884-3646
【異物初期対応から摘出まで】気道の異物

香取幸夫, 桜田晃

ENTONI　96　(96)　54-62　2008/12
Publisher: (株)全日本病院出版会
ISSN： 1346-2067
口腔・中咽頭癌術後患者の口腔・摂食・嚥下機能、QOLの12ヵ月間の経過

小野二美, 上月正博, 志賀清人, 長坂誠, 香取幸夫, 小林俊光

日本摂食・嚥下リハビリテーション学会雑誌　12　(3)　406-406　2008/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
PLPなどにて口腔機能が改善した頭部外傷後9年経過・運動障害性構音障害患者の1例

伊藤秀美, 小坂井秀行, 佐々木具文, 香取幸夫, 中原寛子

日本摂食・嚥下リハビリテーション学会雑誌　12　(3)　439-440　2008/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
声門上喉頭部分切除術後、嚥下リハビリテーションにより摂食可能となった2例

長坂誠, 香取幸夫, 渡邊健一, 山崎宗治, 小林俊光, 上月正博

耳鼻と臨床　54　(Suppl.2)　S175-S178　2008/11
Publisher: 耳鼻と臨床会
ISSN： 0447-7227

eISSN： 2185-1034
喉頭摘出術の手術説明に関するアンケート調査

香取幸夫, 志賀清人, 小林俊光

日本耳鼻咽喉科学会会報　111　(4)　268-268　2008/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
当科におけるT1/T2喉頭・下咽頭癌に対する少量Docetaxel化学療法併用放射線治療の成績

志賀清人, 舘田勝, 浅田行紀, 西川仁, 小川武則, 牧敦子, 片桐克則, 嵯峨井俊, 加藤健吾, 香取幸夫, 小林俊光

日本耳鼻咽喉科学会会報　111　(4)　309-309　2008/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
頭蓋内合併症を来した真珠腫性中耳炎の4症例

山内大輔, 工藤貴之, 高橋悦, 澤田朋啓, 吉田征之, 香取幸夫, 川瀬哲明, 小林俊光, 沖津尚弘, 大山健二

日本耳鼻咽喉科学会会報　111　(4)　331-331　2008/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
軟口蓋挙上装置などにて改善した頭部外傷後8年経過・運動障害性構音障害患者の1例介護と医療の連携

小坂井秀行, 伊藤秀美, 佐々木具文, 香取幸夫, 中原寛子

音声言語医学　49　(1)　47-47　2008/01
Publisher: 日本音声言語医学会
ISSN： 0030-2813

eISSN： 1884-3646
口腔・中咽頭癌外科治療後の発話・摂食・嚥下機能とQOLとの関係

小野仁美, 上月正博, 志賀清人, 長坂誠, 伊藤修, 黒澤一, 金澤雅之, 香取幸夫, 小林俊光

日本摂食・嚥下リハビリテーション学会雑誌　11　(3)　337-338　2007/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
急性喉頭蓋炎の臨床統計

石田英一, 香取幸夫, 渡邊健一, 矢野寿一, 大島英敏, 川瀬哲明, 小林俊光

日本耳鼻咽喉科学会会報　110　(7)　513,np4-519,np4　2007/07
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
A clinical study of 71 cases of acute epiglottitis Peer-reviewed

Ishida E Katori Y, Watanabe, K, Yano, H Oshima H, Kawase, T, Kobayashi T

Nippon Jibiinkoka Gakkai Kaiho　110　(7)　513-519　2007/07

DOI： 10.3950/jibiinkoka.110.513 　

ISSN： 0030-6622
小児気道異物163例の統計 : 近年の66症例と1977年以前の97症例の比較

香取幸夫, 川瀬哲明, 小林俊光

小児耳鼻咽喉科　28　(2)　55-55　2007/06/23

ISSN： 0919-5858
9.口腔・中咽頭癌外科治療後に生じる発話・摂食・嚥下機能障害とQOLとの関係について(第21回日本リハビリテーション医学会東北地方会)

小野二美, 上月正博, 長坂誠, 伊藤修, 黒澤一, 金澤雅之, 志賀清人, 香取幸夫, 小林俊光

リハビリテーション医学 : 日本リハビリテーション医学会誌　44　(6)　358-358　2007/06/18
Publisher: 社団法人日本リハビリテーション医学会
ISSN： 0034-351X
口腔・中咽頭癌外科治療後に生じる発話・摂食・嚥下機能障害とQOLとの関係について

小野二美, 上月正博, 長坂誠, 伊藤修, 黒澤一, 金澤雅之, 志賀清人, 香取幸夫, 小林俊光

The Japanese Journal of Rehabilitation Medicine　44　(6)　358-358　2007/06
Publisher: (公社)日本リハビリテーション医学会
ISSN： 1881-3526

eISSN： 1881-8560
小児気道異物163例の統計近年の66症例と1977年以前の97症例の比較 Peer-reviewed

香取幸夫, 川瀬哲明, 小林俊光

小児耳鼻咽喉科　28　(2)　115-115　2007/06
Publisher: 日本小児耳鼻咽喉科学会
ISSN： 0919-5858

eISSN： 2186-5957
当科における頸部食道癌の治療について

志賀清人, 香取幸夫, 吉田尚弘, 小林俊光

日本気管食道科学会会報　58　(2)　237-237　2007/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
Triamcinolone acetonide(ケナコルト-A)局注が奏効した高位気管切開後の声門下狭窄症例

菊地俊晶, 香取幸夫, 矢野寿一, 渡邊健一, 川瀬哲明, 小林俊光

日本気管食道科学会会報　58　(2)　253-253　2007/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
頸部自傷後に嚥下障害をきたした高齢者2例

渡邊健一, 香取幸夫, 吉田尚弘, 小林俊光

日本気管食道科学会会報　58　(2)　261-261　2007/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
当科における喉頭白板症症例の検討

渡邊健一, 香取幸夫, 臼淵肇, 小林俊光

日本耳鼻咽喉科学会会報　110　(4)　290-290　2007/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
東北大学病院における外来での声帯手術

臼渕肇, 香取幸夫, 渡邊健一, 小林俊光

日本耳鼻咽喉科学会会報　110　(4)　325-325　2007/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
側頭骨削開が有用であった耳下腺多形腺腫術後再々発症例

宮崎浩充, 香取幸夫, 吉田尚弘, 大島猛史, 川瀬哲明, 小林俊光

日本耳鼻咽喉科学会会報　110　(4)　331-331　2007/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
東北大学病院における嚥下障害重症例に対する手術治療の現況

香取幸夫, 渡邊健一, 臼淵肇, 志賀清人, 小林俊光

日本耳鼻咽喉科学会会報　110　(4)　358-358　2007/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
嚥下機能改善手術症例の検討 Peer-reviewed

香取幸夫, 渡邊健一, 小倉正樹, 川瀬哲明, 小林俊光

日本気管食道科学会会報　58　(2)　275-275　2007/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
解剖と機能耳管閉鎖障害シリーズ耳管の系統発生両生類とヒトとの比較

香取幸夫, 小林俊光, 高橋薫

JOHNS　23　(2)　248-249　2007/02
Publisher: (株)東京医学社
ISSN： 0910-6820
東北大学病院における嚥下障害重症例に対する手術治療の現況

香取幸夫, 渡邉健一, 臼渕肇, 志賀清人, 小林俊光

日本気管食道科学会会報　58　275　2007
口腔・頭頸部癌術後に生じる発話機能・摂食嚥下機能障害とQOLの関係について

小野二美, 香取幸夫, 志賀清人, 小林俊光, 上月正博

日本摂食・嚥下リハビリテーション学会雑誌　10　(3)　326-326　2006/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
甲状軟骨形成術I型による嚥下機能改善の評価

香取幸夫, 小倉正樹, 渡邊健一, 小林俊光

耳鼻と臨床　52　(Suppl.4)　S291-S295　2006/11
Publisher: 耳鼻と臨床会
ISSN： 0447-7227

eISSN： 2185-1034
甲状軟骨形成術１型による嚥下機能改善の評価 Peer-reviewed

香取幸夫, 小倉正樹, 渡邊健一, 小林俊光

耳鼻と臨床　52　(s4)　s291　2006/11

DOI： 10.11334/jibi1954.52.6Supplement4_S291 　
口すぼめ呼吸に由来する末梢気道内腔圧の推定

佐野裕子, 黒澤一, 田作豊, 小野二美, 香取幸夫, 小林俊光, 上月正博

日本呼吸管理学会誌　16　(1)　201-201　2006/06
Publisher: (一社)日本呼吸ケア・リハビリテーション学会
ISSN： 0916-9253
歌唱音域と声門下圧との関係

小野二美, 大野奈津子, 黒澤一, 田作豊, 香取幸夫, 小林俊光, 市江雅芳, 上月正博

日本呼吸管理学会誌　16　(1)　229-229　2006/06
Publisher: (一社)日本呼吸ケア・リハビリテーション学会
ISSN： 0916-9253
仮性動脈瘤破裂により頸部に血腫を形成した２例

志賀清人, 吉田尚弘, 香取幸夫, 川瀬哲明, 小林俊光

耳鼻咽喉科臨床　s118　(補冊118)　49-49　2006/06
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
側頭骨に浸潤する扁平上皮癌に対する効果的な化学放射線療法

志賀清人, 小川武則, 西川仁, 吉田尚弘, 香取幸夫, 小林俊光

頭頸部癌　32　(2)　231-231　2006/05
Publisher: (一社)日本頭頸部癌学会
ISSN： 1349-5747

eISSN： 1881-8382
外科的治療を要した喉頭肉芽腫症例の検討

香取幸夫, 小倉正樹, 本間理香子, 小林俊光

日本気管食道科学会会報　57　(2)　240-240　2006/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
パーキンソン病患者の音声と喉頭所見

香取幸夫, 本間理香子, 小倉正樹, 山内大輔, 高橋薫, 吉田尚弘, 小林俊光, 陳志傑

日本耳鼻咽喉科学会会報　109　(4)　339-339　2006/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
保存的治療により嚥下障害の改善を得た皮膚筋炎症例

香取幸夫, 小倉正樹, 小林俊光

耳鼻と臨床　52　(Suppl.1)　S93-S94　2006/01
Publisher: 耳鼻と臨床会
ISSN： 0447-7227

eISSN： 2185-1034
小児気管・気管支異物の診断と治療

香取幸夫, 川瀬哲明, 小林俊光

小児耳鼻咽喉科　26　(2)　67-74　2005/12
Publisher: 日本小児耳鼻咽喉科学会
ISSN： 0919-5858

eISSN： 2186-5957
喉頭軟骨腫瘍の2症例

天野雅紀, 香取幸夫, 嵯峨井俊, 小川武則, 千葉敏彦, 沖津尚弘, 菊地俊彦, 小林俊光

日本耳鼻咽喉科学会会報　108　(9増刊)　884-884　2005/09
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
嚥下障害を呈した皮膚筋炎症例

香取幸夫, 小倉正樹, 高橋薫, 小林俊光, 陳志傑

日本耳鼻咽喉科学会会報　108　(5増刊)　630-630　2005/05
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
マウス耳管におけるアクアポリンの発現様式

高橋悦, 菊地俊彦, 高橋薫, 香取幸夫, 小林俊光

日本耳鼻咽喉科学会会報　108　(5増刊)　631-631　2005/05
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
当院における嚥下障害治療の現状

香取幸夫, 陳志傑, 沖津尚弘, 高橋薫, 高田雄介, 中目亜矢子, 佐藤利徳, 川瀬哲明, 小林俊光

日本耳鼻咽喉科学会会報　108　(5増刊)　646-646　2005/05
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
輪状軟骨に生じた喉頭軟骨肉腫症例

高橋悦, 香取幸夫, 千葉敏彦, 菊地俊彦, 小林俊光

日本耳鼻咽喉科学会会報　108　(5増刊)　649-649　2005/05
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
各種動物における耳管形態

高橋薫, 高橋悦, 香取幸夫, 菊地俊彦, 小林俊光

日本耳鼻咽喉科学会会報　108　(5増刊)　630-631　2005/05
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
耳鼻咽喉科領域の画像診断

香取幸夫

Monograph of Clinical Orthodontics　26　33-37　2005/04
Publisher: 与五沢矯正研究会
ISSN： 0911-8632
耳鼻咽喉科領域の画像診断

香取幸夫

Monograph of Clinical Orthodontics　26　92-93　2005/04
Publisher: 与五沢矯正研究会
ISSN： 0911-8632
気道狭窄を伴った喉頭軟骨腫瘍の2症例

香取幸夫, 高橋悦, 高橋薫, 陳志傑, 千葉敏彦, 菊地俊彦, 小林俊光

日本気管食道科学会会報　56　(2)　245-245　2005/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
東北大学病院NSTの活動について

佐々木巌, 岡芳知, 南文子, 岡本智子, 斎藤真紀子, 横塚紀美子, 宮田剛, 朝倉徹, 柴田近, 香取幸夫, 久道周彦, 佐々木千佳, 中村郁子, 阿部裕子, 藤巻慎一, 遠藤佳子, 細谷信行

静脈経腸栄養　20　(1)　77-77　2005/03
Publisher: (株)ジェフコーポレーション
ISSN： 1344-4980

eISSN： 1881-3623
耳鼻咽喉科領域のレーザー手術早期喉頭癌のレーザー手術と術後の音声機能評価

香取幸夫

耳鼻咽喉科臨床　s115　(補冊115)　110-110　2004/11
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
当科における耳管開放症の診断と治療耳管外来の現況について

高田雄介, 清川裕道, 中目亜矢子, 長谷川純, 千葉敏彦, 佐藤利徳, 香取幸夫, 須納瀬弘, 川瀬哲明, 小林俊光

日本耳鼻咽喉科学会会報　107　(9増刊)　866-866　2004/09
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
声帯外方移動術を施行した3例

香取幸夫, 小林俊光, 鈴木秀明, 陳志傑, 柴原みわ, 中目亜弥子, 工藤貴之, 小倉正樹

日本耳鼻咽喉科学会会報　107　(5増刊)　630-630　2004/05
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
KTP/532レーザー下甲介粘膜下刺入手術に対する有用性の検討

後藤了, 小野寺亮, 浅田行紀, 香取幸夫, 菅原充, 山内大輔

日本耳鼻咽喉科学会会報　107　(5増刊)　630-630　2004/05
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
XPSドリルシステムを使用したポリープ様声帯の手術

香取幸夫, 陳志傑, 小林俊光, 鈴木秀明

日本耳鼻咽喉科学会会報　107　(4)　439-439　2004/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
喉頭顕微鏡手術におけるXPSドリルの使用経験

香取幸夫, 山内大輔, 陳志傑, 小林俊光, 鈴木秀明

日本気管食道科学会会報　55　(2)　174-174　2004/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
縦隔気腫を続発した咽頭外傷症例

工藤貴之, 香取幸夫, 小林俊光

日本気管食道科学会会報　55　(2)　220-220　2004/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
腕頭動脈蛇行症例における気管切開術

堀容子, 橋本省, 香取幸夫, 小岩哲夫, 朴沢孝治, 小林俊光

日本耳鼻咽喉科学会会報　107　(2)　152-155　2004/02
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
口すぼめ呼吸における鼻咽頭閉鎖機構について

佐野裕子, 黒沢一, 上月正博, 香取幸夫, 小林俊光

日本摂食嚥下リハビリテーション学会雑誌　8　(2)　2004

ISSN： 1343-8441
咽頭外傷から縦隔気腫を生じた1症例

工藤貴之, 香取幸夫

日本耳鼻咽喉科学会会報　107　(1増刊)　82-82　2004/01
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
Tracheostomy in Tortuous Brachiocephalic Artery Peer-reviewed

Yoko Hori, Sho Hashimoto, Yukio Katori, Tetsuo Koiwa, Koji Hozawa, Toshimitsu Kobayashi

Journal of Otolaryngology of Japan　107　(2)　152-155　2004
Publisher: Oto-Rhino-Laryngological Society of Japan Inc.
DOI： 10.3950/jibiinkoka.107.152 　

ISSN： 0030-6622
胸鎖乳突筋に発生した筋肉内血管腫例

香取幸夫, 渡邊健一, 小倉正樹, 小林俊光

耳鼻咽喉科臨床　96　(10)　915-918　2003/10
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0032-6313

eISSN： 1884-4545
Conditional knockoutによるgjb2遺伝子欠失マウスの聴覚機能解析

池田勝久, 工藤貴之, 金珍花, 菊地俊彦, 香取幸夫, 渡邉幸二郎, 小林俊光, 後藤了, 美野輪治

Otology Japan　13　(4)　445-445　2003/09
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
原子間力顕微鏡による感覚細胞及び支持細胞の機械的特性の計測

和田仁, 菅原路子, 香取幸夫, 欠畑誠治, 池田勝久, 小林俊光

Otology Japan　13　(4)　559-559　2003/09
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
鼻手術後のビスマスヨードホルムパラフィン軟膏の効果

香取幸夫, 小倉正樹

日本耳鼻咽喉科学会会報　106　(9増刊)　905-905　2003/09
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
鼻科手術後のビスマスヨードホルムパラフィン軟膏の効果

小倉正樹, 香取幸夫

日本耳鼻咽喉科学会会報　106　(9増刊)　930-930　2003/09
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
喉頭横隔膜症の2例

香取幸夫, 小倉正樹, 朴沢孝治

日本耳鼻咽喉科学会会報　106　(9増刊)　931-931　2003/09
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
声門開大術を施行した2例と術後dynamic MRIによる評価

香取幸夫, 工藤貴之, 小倉正樹

日本耳鼻咽喉科学会会報　106　(9増刊)　942-943　2003/09
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
脳底動脈閉塞後に嚥下障害を来し回復した1例 Peer-reviewed

香取幸夫, 小倉正樹, 小林俊光

耳鼻と臨床　49　(5)　354-357　2003/09
Publisher: 耳鼻と臨床会
DOI： 10.11334/jibi1954.49.5_354 　

ISSN： 0447-7227

eISSN： 2185-1034
声帯外方移動術が有効であった両側反回神経麻痺２症例 Peer-reviewed

香取幸夫, 小倉正樹, 渡邊健一, 工藤貴之

岩手県立病院医学会雑誌　43　(1)　49-52　2003/06
Publisher: 岩手県立病院医学会
ISSN： 0385-9320
鼻内内視鏡手術により整復した眼窩内側吹き抜け骨折症例 Peer-reviewed

香取幸夫, 小倉正樹, 工藤貴之, 加藤健吾

岩手県立病院医学会雑誌　43　(1)　53-56　2003/06
Publisher: 岩手県立病院医学会
ISSN： 0385-9320
当科で治療した鼻副鼻腔内向型乳頭腫41症例の検討

山内大輔, 菅原充, 天野雅紀, 小野寺亮, 千葉敏彦, 香取幸夫

日本耳鼻咽喉科学会会報　106　(5増刊)　620-621　2003/05
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
口腔に広範に進展した,ガンマグロブリン血症を伴うアミロイドーシスの1症例

小倉正樹, 香取幸夫, 下瀬川健二

日本耳鼻咽喉科学会会報　106　(5増刊)　621-621　2003/05
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
声門部疾患に対するMRI評価の試み

香取幸夫, 小倉正樹, 後藤英雄, 佐藤隆一

日本耳鼻咽喉科学会会報　106　(5増刊)　627-627　2003/05
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
喉頭横隔膜症の2症例

香取幸夫, 朴沢孝治, 小倉正樹

日本気管食道科学会会報　54　(2)　127-127　2003/04
Publisher: (NPO)日本気管食道科学会
ISSN： 0029-0645

eISSN： 1880-6848
発声・構音時のDynamic MRI撮影の試み

香取幸夫, 小倉正樹, 工藤貴之, 小林俊光

日本耳鼻咽喉科学会会報　106　(4)　369-369　2003/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
腕神経叢神経鞘腫に対する披膜間全摘出術

橋本省, 香取幸夫, 高橋千穂, 欠畑誠治, 千葉敏彦

日本耳鼻咽喉科学会会報　106　(1増刊)　104-105　2003/01
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
アレルギー性鼻炎に対するKTPレーザー下鼻甲介粘膜下刺入法の有効性の検討

菅原充, 山内大輔, 小野寺亮, 香取幸夫, 日高浩史, 千葉敏彦

日本耳鼻咽喉科学会会報　106　(1増刊)　106-106　2003/01
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
シリコンブロック固定が有用であった内側型眼窩骨折

香取幸夫, 小倉正樹, 加藤健吾

日本耳鼻咽喉科学会会報　106　(1増刊)　106-106　2003/01
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
当科外来におけるMRSA検出症例の検討

小倉正樹, 香取幸夫

日本耳鼻咽喉科学会会報　106　(1増刊)　131-131　2003/01
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
過去4年間の当科外来におけるMRSA検出症例の検討

小倉正樹, 香取幸夫

耳鼻咽喉科臨床補冊　(補冊108)　58-58　2002/11
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
GJB2遺伝子変異マウスの聴覚機能解析

工藤貴之, 池田勝久, 小林俊光, 香取幸夫

Audiology Japan　45　(5)　573-574　2002/09
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
外有毛細胞骨格の微細構造観察原子間力顕微鏡を用いて

菅原路子, 和田仁, 香取幸夫, 欠畑誠治, 池田勝久, 小林俊光

Audiology Japan　45　(5)　587-588　2002/09
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
気管切開術と血管走行異常

堀容子, 橋本省, 香取幸夫, 小岩哲夫, 朴沢孝治, 小林俊光

日本耳鼻咽喉科学会会報　105　(5増刊)　680-680　2002/05
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
喉頭摘出後のグローニンゲン・ボイスボタンの使用経験

香取幸夫, 朴沢孝治, 高橋千穂, 沖津尚弘, 堀容子, 橋本省, 小林俊光, 千葉敏彦

日本耳鼻咽喉科学会会報　105　(5増刊)　681-681　2002/05
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
嚥下障害患者におけるVideofluoroscopyと嚥下圧の同時測定の試み

鈴木雅明, 大島猛史, 池田勝久, 西川仁, 香取幸夫, 朴沢孝治, 粟田口敏一

日本耳鼻咽喉科学会会報　105　(5増刊)　711-711　2002/05
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
喉頭に発生したSchwannomaの1例

沖津尚弘, 朴沢孝治, 香取幸夫, 高橋千穂

日本耳鼻咽喉科学会会報　105　(5増刊)　709-709　2002/05
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
喉頭早期癌治療後の音声機能の評価

香取幸夫, 朴沢孝治, 高橋千穂, 沖津尚弘, 西川仁

日本耳鼻咽喉科学会会報　105　(5増刊)　709-710　2002/05
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
早期喉頭癌に対する放射線療法とレーザー手術の比較検討

織田潔, 朴沢孝治, 志賀清人, 中野浩, 香取幸夫, 小林俊光

日本耳鼻咽喉科学会会報　105　(5増刊)　715-716　2002/05
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
腕神経叢に発生した神経鞘腫症例

香取幸夫, 橋本省, 欠畑誠治, 須納瀬弘, 高橋千穂, 小岩哲夫, 本間理香子, 西川仁, 朴沢孝治

日本耳鼻咽喉科学会会報　105　(5増刊)　715-715　2002/05
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
突発性難聴に対する脱繊維素原療法の効果

鈴木秀明, 古川正幸, 松浦一登, 高橋悦, 下村明, 香取幸夫

日本耳鼻咽喉科学会会報　105　(5増刊)　711-712　2002/05
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
血友病A患者の鼻出血におけるデスモプレシン鼻内投与の経験

渡邊健一, 香取幸夫

日本耳鼻咽喉科学会会報　105　(5増刊)　717-717　2002/05
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
上咽頭に発生した成人T細胞白血病リンパ腫症例

香取幸夫, 小倉正樹

日本耳鼻咽喉科学会会報　105　(4)　485-485　2002/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
腕神経叢に発生した神経鞘腫

高橋千穂, 橋本省, 香取幸夫, 小岩哲夫

耳鼻咽喉科臨床補冊　(補冊106)　46-46　2001/11
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0912-1870

eISSN： 2185-1557
原子間力顕微鏡を用いた外有毛細胞側壁の形状観察

菅原路子, 和田仁, 香取幸夫, 欠畑誠治, 池田勝久, 小林俊光

Otology Japan　11　(4)　403-403　2001/10
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
マウス蝸牛発生過程におけるConnexin30及びConnexin31の分布様式

夏安萍, 香取幸夫, 池田勝久, 小林俊光

Otology Japan　11　(4)　544-544　2001/10
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
Brain-4欠失マウスにおけるヘテロ変異体の進行性難聴

池田勝久, 夏安泙, 香取幸夫, 大島猛史, 小林俊光

Otology Japan　11　(4)　400-400　2001/10
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
原子間力顕微鏡を用いた外有毛細胞の機械的特性計測

菅原路子, 和田仁, 香取幸夫, 欠畑誠治, 池田勝久, 小林俊光

Audiology Japan　44　(5)　333-334　2001/09
Publisher: (一社)日本聴覚医学会
ISSN： 0303-8106

eISSN： 1883-7301
KTPレーザーによる喉頭血管腫の治療

西川仁, 朴沢孝治, 香取幸夫, 高橋千穂

日本耳鼻咽喉科学会会報　104　(9増刊)　901-901　2001/09
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
喉頭全摘後の音声獲得能

吉田征之, 朴沢孝治, 香取幸夫, 高橋千穂, 西川仁

日本耳鼻咽喉科学会会報　104　(9増刊)　900-901　2001/09
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
マウス蝸牛におけるインテグリンの免疫組織化学的局在

香取幸夫, 夏安萍, 池田勝久

日本耳鼻咽喉科学会会報　104　(4)　423-423　2001/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
早期喉頭癌のレーザー治療におけるCONTACT ENDOSCOPYの有用性について

高橋千穂, 朴沢孝治, 香取幸夫

日本耳鼻咽喉科学会会報　104　(4)　442-442　2001/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
超選択的動注療法を併用した鼻副鼻腔進行癌の治療

横山純吉, 池田勝久, 小岩哲夫, 香取幸夫, 橋本省

日本鼻科学会会誌　39　(4)　365-369　2000/12
Publisher: (一社)日本鼻科学会
ISSN： 0910-9153

eISSN： 1883-7077
当科における下顎歯肉癌の臨床的検討

横山純吉, 橋本省, 池田勝久, 朴沢孝治, 香取幸夫, 小岩哲夫, 館田勝, 志賀清人, 西條茂

口腔・咽頭科　13　(1)　80-80　2000/08
Publisher: 日本口腔・咽頭科学会
ISSN： 0917-5105

eISSN： 1884-4316
慢性副鼻腔炎患者の副鼻腔粘膜におけるHeme oxygenaseの発現

小岩哲夫, 香取幸夫, 大島猛史, 渡邊幸二郎, 池田勝久

日本鼻科学会会誌　39　(3)　196-196　2000/08
Publisher: (一社)日本鼻科学会
ISSN： 0910-9153

eISSN： 1883-7077
FDG-PETを用いた副鼻腔癌再発診断の有用性の検討

横山純吉, 池田勝久, 橋本省, 小岩哲夫, 香取幸夫

日本鼻科学会会誌　39　(3)　210-210　2000/08
Publisher: (一社)日本鼻科学会
ISSN： 0910-9153

eISSN： 1883-7077
気道狭窄を伴う喉頭血腫を生じた2症例

香取幸夫, 日高浩史, 小野寺亮, 熊谷正樹, 板垣政信

日本耳鼻咽喉科学会会報　103　(5増刊)　715-715　2000/05
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
【舌癌】舌癌III・IV期の治療舌癌の高用量CDDPの超選択的動注療法

横山純吉, 橋本省, 小岩哲夫, 香取幸夫, 志賀清人, 西條茂, 高坂知節

JOHNS　16　(4)　619-625　2000/04
Publisher: (株)東京医学社
ISSN： 0910-6820
咽喉頭異常感に対するPPIの効果

朴沢孝治, 香取幸夫, 大道弘之, 高坂知節

日本耳鼻咽喉科学会会報　103　(4)　409-409　2000/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
内耳発生過程におけるconnexin 26とNa,K-ATP aseの発現様式

菊地俊彦, 夏安平, 香取幸夫, 朴沢孝治, 高坂知節, 小林俊光

日本耳鼻咽喉科学会会報　103　(4)　452-452　2000/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
アレルギー性鼻炎に対する下甲介粘膜下刺入法によるKTPレーザー治療

香取幸夫, 日高浩史, 小野寺亮

日本レーザー医学会誌　20　(3)　302-302　1999/09
Publisher: (NPO)日本レーザー医学会
ISSN： 0288-6200

eISSN： 1881-1639
血管条辺縁細胞における細胞骨格の分布様式

菊地俊彦, 香取幸夫, 高坂知節

Otology Japan　9　(4)　339-339　1999/08
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
A case of soft palate Schwannoma

Y. Katori

Otolaryngology - Head and Neck Surgery (Tokyo)　71　406-407　1999/07/17

ISSN： 0914-3491
目でみる耳鼻咽喉科軟口蓋に発生した神経鞘腫の1症例

香取幸夫, 菊地俊彦, 藤原浩子, 工藤貴之, 湯田文朗

耳鼻咽喉科・頭頸部外科　71　(7)　406-407　1999/06
Publisher: (株)医学書院
ISSN： 0914-3491

eISSN： 1882-1316
マウス蝸牛発生過程におけるNa,K-ATPase及びconnexin 26の発現様式

夏安平, 菊地俊彦, 朴沢孝治, 山口和美, 高坂知節, 香取幸夫

日本耳鼻咽喉科学会会報　102　(5増刊)　713-713　1999/05
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
上顎骨に発生したセメント質形成性線維腫の1例

熊谷正樹, 小野寺亮, 香取幸夫

日本耳鼻咽喉科学会会報　102　(5増刊)　716-716　1999/05
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
甲状腺髄様癌の1例

工藤貴之, 菊地俊彦, 香取幸夫, 藤原浩子, 志賀伸之, 湯田文朗, 野村隆, 遠藤里見

耳鼻と臨床　45　(1)　29-33　1999/01
Publisher: 耳鼻と臨床会
ISSN： 0447-7227

eISSN： 2185-1034
内耳有毛細胞不動毛の微細構造抗ケラタン硫酸抗体と抗エラスチン抗体を用いた免疫組織化学

香取幸夫

Proceedings of Clinical Electron Microscopy　20　11-18　1998/12
Publisher: 東北臨床超微形態懇話会世話人会
モルモット前庭感覚上皮のcadherinに対する免疫組織化学

香取幸夫, 高坂知節

Otology Japan　8　(4)　389-389　1998/09
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
軟口蓋に発生した神経鞘腫の1症例

香取幸夫, 菊地俊彦, 藤原浩子, 工藤貴之, 湯田文朗

口腔・咽頭科　11　(1)　100-100　1998/08
Publisher: 日本口腔・咽頭科学会
ISSN： 0917-5105

eISSN： 1884-4316
副甲状腺腺腫による原発性副甲状腺機能亢進症の1症例

菊地俊彦, 香取幸夫, 藤原浩子, 工藤貴之, 遠藤里見, 野村隆, 斎藤雅昭, 杉田礼児, 高橋邦夫, 湯田文朗

山形市立病院済生館医学雑誌　23　(1)　48-52　1998/08
Publisher: 山形市立病院済生館医学雑誌編集委員会
ISSN： 0385-1184
蝶形骨洞真菌症の診断と外科的治療

菊地俊彦, 香取幸夫, 藤原浩子, 工藤貴之, 遠藤里見, 高坂知節, 湯田文朗

山形市立病院済生館医学雑誌　23　(1)　3-6　1998/08
Publisher: 山形市立病院済生館医学雑誌編集委員会
ISSN： 0385-1184
POU転写因子Brain-4欠失マウスの形態異常

香取幸夫

日本耳鼻咽喉科学会会報　101　(4)　463-463　1998/04
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
POU転写因子 Brain-4 欠失マウスの聴覚異常

池田勝久, 大島猛史, 香取幸夫, 鈴木雅明, 古川正幸, 渡邊健一, 浅田行紀, 川瀬哲明, 菊地俊彦, 鄭玉蓮, 高坂知節

Otology Japan　7　(4)　487-487　1997/09/20

ISSN： 0917-2025
Deep Etching 法による蓋膜微細構築の三次元的解析

菊地俊彦, 香取幸夫, 朴沢孝治, 高坂知節

Otology Japan　7　(4)　389-389　1997/09/20

ISSN： 0917-2025
モルモット蝸牛有毛細胞における不動毛間架橋構造のケラタン硫酸及びエラスチンに対する免疫組織化学

香取幸夫

Otology Japan　7　(4)　274-274　1997/09
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
Localization of beta-cytoplasmic actin in guinea pig organ of Corti using post-embedding immunogold labelling

Y. Katori, S. Mahendrasingam, D. N. Furness, C. M. Hackney

British Journal of Audiology　31　74-75　1997/01/01

ISSN： 0300-5364
Localization of cadherin in guinea-pig organ of Corti using post-embedding immunogold labelling

S. Mahendrasingam, Y. Katori, D. N. Furness, C. M. Hackney

British Journal of Audiology　31　73-74　1997/01/01

ISSN： 0300-5364
The relationship between extracellular linkages and the stereociliary cytoskeleton in demembranated cochlear hair cells

Y. Katori, D. N. Furness, C. M. Hackney

British Journal of Audiology　30　92-93　1996/05/20

ISSN： 0300-5364
内視鏡下レーザー手術を行った上咽頭嚢胞症例

大道弘之, 香取幸夫, 池田勝久

耳鼻咽喉科臨床　88　(12)　1595-1598　1995/12
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0032-6313

eISSN： 1884-4545
OSASに対するKTPレーザーの使用経験舌根正中部切除術

池田勝久, 香取幸夫, 下村明

耳鼻咽喉科臨床　88　(8)　1061-1065　1995/08
Publisher: 耳鼻咽喉科臨床学会
ISSN： 0032-6313

eISSN： 1884-4545
A COMPARISON OF THE IMMUNOLABELING PATTERNS WITH ANTIBODIES TO KERATAN SULFATE AND ELASTIN IN GUINEA-PIG COCHLEA HAIR BUNDLES

Y KATORI, CM HACKNEY, DN FURNESS

JOURNAL OF PHYSIOLOGY-LONDON　485P　P32-P33　1995/06

ISSN： 0022-3751
Ho:YAGレーザーと内視鏡下鼻内手術

池田勝久, 大島猛史, 鈴木秀明, 下村明, 香取幸夫, 平野浩二, 稲村直樹, 高坂知節

耳鼻臨床　86　(11)　1427-1431　1995
Usage of KTP/532 Laser in the Treatment of Obstructive Sleep Apnea Syndrome—Midline Glossectomy—

Katsuhisa Ikeda, Yukio Katori, Akira Shimomura, Hideaki Suzuki, Takeshi Oshima, Hiroyuki Daido, Naoki Inamura, Tomonori Takasaka, Wataru Hida

Practica Oto-Rhino-Laryngologica　88　(8)　1061-1065　1995

DOI： 10.5631/jibirin.88.1061 　

ISSN： 0032-6313
Holmium: YAG Laser in Endoscopic Sinus Surgery

Katsuhisa Ikeda, Takeshi Oshima, Hideaki Suzuki, Akira Shimomura, Yukio Katori, Koji Hirano, Naoki Inamura, Tomonori Takasaka

Practica Oto-Rhino-Laryngologica　88　(11)　1427-1431　1995

DOI： 10.5631/jibirin.88.1427 　

ISSN： 0032-6313
Extirpation of Epipharyngeal Cyst with KTP/532 Laser; a Report of Two Cases

Hiroyuki Daido, Yukio Katori, Katsuhisa Ikeda

Practica Oto-Rhino-Laryngologica　88　(12)　1595-1598　1995

DOI： 10.5631/jibirin.88.1595 　

ISSN： 0032-6313
有毛細胞頂面の構造ヤツメウナギ神経丘を中心に

香取幸夫

解剖学雑誌　69　(6)　799-800　1994/12
Publisher: (一社)日本解剖学会
ISSN： 0022-7722
閉塞性睡眠時無呼吸症候群に対するKTP/532レーザーによる舌根正中部切除術の一症例

池田勝久, 香取幸夫, 下村明, 鈴木秀明, 稲村直樹, 大道弘之, 高坂知節, 飛田渉

口腔・咽頭科 = Stomato-pharyngology　7　(1)　52-52　1994/08/31

ISSN： 0917-5105
内視鏡下レーザー手術によって摘出した上咽頭嚢胞症例

香取幸夫

口腔・咽頭科　7　(1)　104-104　1994/08
Publisher: 日本口腔・咽頭科学会
ISSN： 0917-5105

eISSN： 1884-4316
コルチ器頂面の内・外有毛細胞および支持細胞の頂面構造の分化レクチン結合性

香取幸夫

解剖学雑誌　69　(4)　501-501　1994/08
Publisher: (一社)日本解剖学会
ISSN： 0022-7722
ラセン器細胞頂面における小麦胚芽レクチン反応部位反射電子SEM像による検出

香取幸夫

解剖学雑誌　69　(1)　94-94　1994/02
Publisher: (一社)日本解剖学会
ISSN： 0022-7722
ヤツメウナギ側線感丘の細胞構成と頂面構造

香取幸夫

解剖学雑誌　68　(6)　690-690　1993/12
Publisher: (一社)日本解剖学会
ISSN： 0022-7722
ヤツメウナギ感丘細胞頂表面の微細構造について

香取幸夫

Journal of Electron Microscopy　42　(4)　273-273　1993/08
Publisher: Oxford University Press
ISSN： 0022-0744

eISSN： 1477-9986
ヤツメウナギneuromastの頂面構造

香取幸夫

解剖学雑誌　68　(2)　255-255　1993/04
Publisher: (一社)日本解剖学会
ISSN： 0022-7722
Dissociation of the Submucosal Nasal Gland of the Nasal Septum in Guinea Pigs.

Ishigaki Motoaki, Ikeda Katsuhisa, Sunose Hiroshi, Katori Yukio, Suzuki Masaaki, Takasaka Tomonori

Pract.Otol. (Kyoto)　86　(10)　1475-1480　1993
Publisher: The Society of Practical Otolaryngology
DOI： 10.5631/jibirin.86.1475 　

ISSN： 0032-6313

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A dissociation procedure for acinar cells of the nasal gland in the guinea pig has been developed. Under a whole mount of the nasal septum, the majority of nasal glands was distributed in the infraanterior area of the olfactory region and in the posterior area of the respiratory region. This technique employs meticulous and selective dissection with minimal contamination of epithelial cells and enzymatic treatment with collagenase. The dissociated cells were confirmed to be serous gland acini by negative stain with alcian blue and a relatively high electron density of secretory granules. More than 90% of acini were viable as judged by trypan blue exclusion. Ultrastructual integrity of the cell was well maintained following the dissociation procedure.
ヤツメウナギneuromast頂面の微細構造

香取幸夫

Otology Japan　3　(1)　118-118　1993/01
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
走査型電子顕微鏡およびディープエッチング法によるモルモット蝸牛基底板線維の三次元的観察

香取幸夫

Otology Japan　1　(3)　76-76　1991/08
Publisher: (一社)日本耳科学会
ISSN： 0917-2025

eISSN： 1884-1457
Canine Ear Mite, Otodectes Cynotis, Found on Both Tympanic Membranes of an Adult Woman.

Mitsuko Suetake, Ryo Yuasa, Shigeru Saijo, Seiji Kakehata, Yukio Katori, Atsuhiro Koizumi, Haruo Kamiya, Takashi Inaba

Practica Oto-Rhino-Laryngologica　84　(6)　739-742　1991

DOI： 10.5631/jibirin.84.739 　

ISSN： 0032-6313
X線CTによる鼻骨骨折の診断

香取幸夫

日本耳鼻咽喉科学会会報　92　(9)　1458-1458　1989/09
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
鼓室形成術後聴力成績判定基準(案)についてアンケート調査との比較

香取幸夫

日本耳鼻咽喉科学会会報　92　(8)　1287-1287　1989/08
Publisher: (一社)日本耳鼻咽喉科学会
ISSN： 0030-6622

eISSN： 1883-0854
鼓室形成術後聴力成績判定基準(案)についてアンケート調査との比較

香取幸夫

臨床耳科　15　(3)　28-28　1988/10
Publisher: (一社)日本耳科学会
ISSN： 0387-8848

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Presentations 34

Characteristics of Aspiration Pneumonia Patients in Acute Care Hospital Invited

2022/09/14
嚥下障害の診療専門性を活かす Invited

香取幸夫

第79回新都心ENT研究会　2022/09/01
嚥下障害の機序と治療 Invited

香取幸夫

第12回日本腎臓リハビリテーション学会学術集会（岡山）　2022/03/27
Surgical treatment of dysphagia Invited

Yukio Katori

3rd World Dysphagia Summit　2021/08/22
Relationship of pharynx and esophagus Invited

Yukio Katori

JSDR2021　2021/08/21
Development of the treatment of dysphagia : cooperation of medicine, dentistry and engineering. Invited

Yukio Katori

122nd annual meeting of Japan Society of Otorhinolaryngology and Head and Neck Surgery　2021/05/14
嚥下障害への対応：誤嚥、肺炎の予防と治療 Invited

香取幸夫

長崎県耳鼻咽喉科専門講座　2021/03/18
嚥下を学ぶー頭頸部領域からー Invited

香取幸夫

第31回日本気管食道科学会認定気管食道科専門医大会　2021/02/27
嚥下障害への対応 Invited

香取幸夫

第50回富山県耳鼻咽喉科疾患研究会　2020/12/06
音声治療を行った小児の３症例

香取幸夫

第15回日本小児耳鼻咽喉科学会　2020/12/02
医科歯科連携を活かす摂食嚥下障害の診療 Invited

香取幸夫

第46回日本口腔外科学会総会北日本支部学術講演会　2020/11/04
高齢者の嚥下障害を診る Invited

香取幸夫

第121回日本耳鼻咽喉科学会学術講演会　2020/10/06
嚥下障害の治療ー耳鼻咽喉科における対応ー Invited

香取幸夫

第141回札幌市耳鼻咽喉科医会学術研修会　2020/09/12
高齢者の摂食嚥下障害と誤嚥予防 Invited

香取幸夫

careTEXセミナー　2020/09/10
誤嚥の検出と予防～耳鼻咽喉科によるアプローチ～ Invited

香取幸夫

第1回阪神耳鼻咽喉科クリニカルフォーラム　2020/02/15
ICU管理を要する重症頸部感染症患者への対応～早期機能回復を目指す耳鼻咽喉科のアプローチ Invited

香取幸夫

第12回東北セプシスセミナー　2020/02/08
Swallowing function after segmental mandibulectomy and reconstruction using a CAD/CAM system Invited

NAKANOME Ayako, KATORI Yukio

15th Japan Taiwan Conference on Otolaryngology and Head and Neck Surgery　2019/12/06
The situation of surgical training using donated cadavers in Japan (Cadaveric Temporal Bone dissection Course in Tohoku University) International-presentation Invited

KATORI Yukio, YAMAUCHI Daisuke, HONKURA Yohei

29th Annual Meeting of Japan Society of Otologist　2019/10/10
嚥下機能及び嚥下機能障害に関わる総論 Invited

香取幸夫

第13回日本嚥下医学会主催嚥下機能評価研修会プログラム　2019/09/29
Limitation of Cadaver Dissection in Japan (Cadaveric Temporal Bone dissection Course in Tohoku University) International-presentation Invited

KATORI Yukio

Cochlea Scientific Board Meeting in Sydney　2019/08/05
喉頭解剖～音声外科に関連する構造を中心に～ Invited

香取幸夫

音声外科ワークショップ２０１９　2019/07/27
Surgical treatment of severe dysphagia International-presentation Invited

KATORI Yukio

Seminar in Otolaryngology, Florida University　2019/07/12
アクティブシニアライフ実現に向けた耳鼻咽喉科的アプローチ：耳鼻咽喉科と医工学との連携による嚥下診療へのアプローチ Invited

香取幸夫

第81回日本耳鼻咽喉科臨床学会パネルディスカッション　2019/06/28
誤嚥の検出と予防～耳鼻咽喉科によるアプローチ～ Invited

香取幸夫

日耳鼻秋田県地方部会耳鼻咽喉科専門医領域講習　2019/06/23
嚥下内視鏡検査と起こりうる合併症見逃してはいけない粘膜病変 Invited

香取幸夫

）日本老年歯科医学会摂食機能療法専門歯科医師指定研修会　2019/06/08
高齢者の嚥下障害を診る Invited

香取幸夫

第61回日本老年医学会教育講演　2019/06/07
嚥下障害と胃食道逆流症 Invited

香取幸夫

第6回阿倍野耳鼻咽喉科臨床講習会　2019/05/25
嚥下障害診療における医療連携～大学の役割～ Invited

香取幸夫

第120回日本耳鼻咽喉科学会シンポジウム１０　2019/05/10
嚥下障害と胃食道逆流症 Invited

香取幸夫

第88回奈良県耳鼻咽喉科講習会　2019/04/13
Central Part Laryngectomy for preventing aspiration achieves broad pharynx and loose entry of esophagus International-presentation Invited

KATORI Yukio

14th Asia Oceania ORL-HNS Congress　2019/01/12
Dysphagia in Head and Neck Cancer Patients: Two topics from our study International-presentation Invited

KATORI Yukio

14th Asia Oceania ORL-HNS Congress　2019/01/12
嚥下障害と誤嚥予防の医学知識むせやすい方や飲み込みにくい方のための予防と対応 Invited

香取幸夫

介護職スキルアップ講座仙台市　2022/01/28
嚥下障害の治療関連する肺炎の特徴と予防 Invited

香取幸夫

第78回日耳鼻愛媛県地方部会学術集会　2022/01/22
嚥下障害の治療誤嚥の検出と予防 Invited

香取幸夫

鹿児島大学耳鼻咽喉科・頭頸部外科学教室同門会　2022/01/15

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Industrial Property Rights 3

超音波透過法を用いた誤嚥検出装置

原陽介, 瀧宏文, 香取幸夫, 芳賀洋一, 出江紳一, 永富良一

Property Type: Patent
人工舌用または舌部埋込型アクチュエータ、人工舌、人工舌システム

山家智之, 香取幸夫, 川瀬哲明, 山内大輔, 加藤健吾, 白石泰之, 井上雄介

Property Type: Patent
長尺状の医療器具の保持機構

山内大輔, 芳賀洋一, 川瀬哲明, 香取幸夫, 秋山恭一, 松永忠雄

Property Type: Patent

Research Projects 27

Environmental control methods based on the elucidation of the rute of MRSA transmission to environmental reservoirs in otorhinolaryngology.

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2024/04/01 - 2028/03/31
Join U.S.-Japan Measures for Aging and Dementia Derived from the Prevention of Age-related and Noise-induced Hearing Loss

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Fund for the Promotion of Joint International Research (International Collaborative Research)

Institution: Tohoku University

2023/10 - 2028/03
Monitoring of residual food in hypopharynx using near-infrared fluorescence: aspiration risk detection and treatment with electrical stimulation

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: The University of Electro-Communications

2024/04/01 - 2027/03/31
Neurophysiological analysis of oral function improvement using diffusion tensor imaging

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2023/04/01 - 2026/03/31
Research of a novel treatment for dysphagia focusing on cell protection and anti-inflammatory effects of transcription factor Nrf2

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2022/04 - 2025/03
近赤外蛍光を用いた誤嚥リスク検出装置の開発

小池卓二

Offer Organization: 日本医療研究開発機構日本医療研究開発機構研究費

System: 医療分野研究成果展開事業

Institution: 電気通信大学（小池班）

2022/07 - 2023/03
ヘリコバクターシネディ感染症の治療戦略構築と伝播様式の解明 Competitive

野村和弘

Offer Organization: 文部科学省

System: 科学研究費助成事業基盤研究（Ｃ）

2019/04 - 2023/03
嚥下障害患者の安全な経口摂取に寄与する咽喉頭感覚障害評価法の研究開発 Competitive

香取幸夫

Offer Organization: 日本医療研究開発機構

System: 日本医療研究開発機構研究費障害者対策総合研究開発事業

2019/08 - 2022/03
PGC-1α/Nrf2経路に着目した運動による難聴予防機序の解明と予防法の開発 Competitive

香取幸夫

Offer Organization: 文部科学省

System: 科学研究費助成事業基盤研究（B）

2018/04 - 2022/03
先天性および若年性の視覚聴覚二重障害の原因となる難病の診療向上に向けた、疾患横断的な全国多施設レジストリ研究 Competitive

松永達雄

Offer Organization: 日本医療研究開発機構

System: 日本医療研究開発機構研究費難治性疾患等実用化研究事業難治性疾患実用化研究事業

2018/04 - 2021/03
ノイズ並びに自声を用いた新規耳管機能検査装置の開発 Competitive

菊地俊晶

Offer Organization: 文部科学省

System: 科学研究費助成事業基盤研究（Ｃ）

2018/04 - 2021/03
痙攣性発声障害疾患レジストリ開発と運用に関する研究 Competitive

讃岐徹治

Offer Organization: 厚生労働省

System: 厚生労働科学研究費補助金難治性疾患等政策研究事業

2018/04 - 2020/03
ハイドロゲル埋め込み電極を用いた治療的電気刺激による嚥下障害治療モデルの開発 Competitive

小川武則

Offer Organization: 文部科学省

System: 科学研究費助成事業基盤研究（Ｃ）

2017/04 - 2020/03
嚥下障害に対する包括的嚥下障害基礎訓練法の開発と有効性の検討 Competitive

香取幸夫

Offer Organization: 日本医療研究開発機構

System: 障害者対策総合研究開発事業

2017/04 - 2020/03
次世代AI技術を用いたリアルタイム音声障害診断システムに関する研究開発 Competitive

讃岐徹治

Offer Organization: 国立研究開発法人日本医療研究開発機構

System: 医療研究開発推進事業費補助金橋渡し研究戦略的推進プログラム

2018/04 - 2019/03
神経線維腫症Ⅱ型に対する蝸牛温存型低侵襲水中内視鏡下経迷路法の確立に関する研究 Competitive

山内大輔

Offer Organization: 文部科学省

System: 科学研究費助成事業基盤研究（Ｃ）

2016/04 - 2019/03
後迷路性難聴モデル動物の神経障害パターンに関する検討―生理学的特質と異受傷性― Competitive

野口直哉

Offer Organization: 文部科学省

System: 科学研究費助成事業基盤研究（Ｃ）

2015/04 - 2019/03
摂食における咀嚼・嚥下複合体の解析：フレキシブル電極を用いた非侵襲的検査の研究 Competitive

香取幸夫

Offer Organization: 文部科学省

System: 科学研究費助成事業基盤研究（Ｃ）

2015/04 - 2018/03
発声における聴覚フィードバック機構の動的可視化とミラーニューロンの局在・機能同定 Competitive

川瀬哲明

Offer Organization: 文部科学省

System: 科学研究費助成事業挑戦的萌芽研究

2015/04 - 2018/03
耳管周囲組織をターゲットとした新しい耳管閉鎖障害モデル・治療戦略の確立 Competitive

菊地俊晶

Offer Organization: 文部科学省

System: 科学研究費助成事業基盤研究（Ｃ）

2014/04 - 2017/03
マウス蝸牛におけるＡＰＣ蛋白の発現の検討－アクチン配列の制御と障害回復との関係－ Competitive

香取幸夫

Offer Organization: 文部科学省

System: 科学研究費助成事業基盤研究（Ｃ）

2013/04 - 2015/03
子音生成時の電気的パラトグラムによる構音・摂食・嚥下障害への構音訓練の臨床的検討 Competitive

佐々木具文

Offer Organization: 文部科学省

System: 科学研究費補助金基盤研究（Ｃ）

2007/04 - 2009/03
有毛細胞の音受容に関与するアクチン関連蛋白と遺伝性難聴ＤＦＮＡ２０／２６の研究 Competitive

香取幸夫

Offer Organization: 文部科学省

System: 科学研究費補助金基盤研究（Ｃ）

2007/04 - 2009/03
生体内パッチクランプ法を用いた三叉神経を介する耳閉感派生機序の解明 Competitive

吉田尚弘, 香取幸夫

Offer Organization: 文部科学省

System: 科学研究費補助金萌芽研究

2005/04 - 2007/03
Between Rehabitation and ＆orders of speech, swalowing, deglutition of speech production of vowels and consonants Including glossectomies patents using 4D-MRI limagings and EPG

SASAKI Tomofumi, ITOH Hidemi, IMAIZUMI Satoshi, KATORI Yukio, MORIKAWA Hidehiro, HONDA Kiyoshi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2005 - 2006

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The aim of this research was to estabhsh of the program for the rehabitation into society that used 4D-MRI, EPG, VF and VE etc to investigate between articulation and swalowing, deglutition of oral some structures inducting giossectmies patients, and then basic date of Normal subjects. The content of the research : 1. Case of Normal subjects : 1) In speech production of five vowels, vocal tract shape of al mid-sagittal plane were definitely differents. 2) In speech production of six consonants, vocal tract she of al mid-sagittal plane were difference between plosives /ta/・/ki・//ka/and fricative /sa/・/Sa/・/Ca/, and then especially speech production of plosion /ta/・/ki/・/ka/ were suggested to affect (1) hard palate' she to lingual articulation, (2) relation with soft palate and passavan processes, (3) shape ' change of upper pharyngeal and midle pharyngeal, and then (4) ＆lance brig from Lips. 3) In swallowing and deglutition, both oral some structures and mechanism were concern to lingual movement, soft palate, pharyngeal and the n epiglottic. 2. Case of Normal subjects with attached prosthesis :1) In speech production of five vowels, vocal tract shape of al mid-sagittal plane ware definitely differents. 2) In speech production of six consonants, vocal tract shape of al mid-sagittal plane were difference between plosion /ta/・/ki/・/ka/ and fricative /sa/・/Sa/・/Ca/. 3) EPG of palatogram of plosion /ta/・/ki/-/ka/ and fricative /sa/・/Sa/ /Ca/.were very differents of the contact area of closure for the stop /t/ and the constriction of the fricative /s/, and then their EPG of palatogram were prominent asymmetry of the lingal contact along both sides of the palate. 3. Case of the lingually attached prosthesis that had installed the tongue in the patient who excised a half side:1) articulation function were improved, and then swallowing and deglutition were short of times, also improved of function of lingual, soft palate, pharyngeal. Therefore, it was suggesuted that relationship between articulation and swallowing, deglutition were concerned.
Analysis of the potassium ion recycling mechanism in the cochlea : a challenge for the better understanding of the inner ear dysfunction

KIKUCHI Toshihiko, KAWASE Tetsuaki, KATORI Yukio, YOSHIDA Naohiro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2004 - 2005

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In the mammalian inner ear, there are two independent gap junction systems, the epithelial cell gap junction system and the connective tissue cell gap junction system. Potassium ions, which play a pivotal role in the mechanoelectrical transduction process in the mammalian cochlea, are recycled via these two gap junction systems. Four different connexins, including connexin 26, 30, 31, and 43, have been reported in the mammalian inner ear. Connexin 26, 30, and 43 are distributed in both epithelial and connective tissue cell gap junction systems. In contrast, connexin 31 is localized to the connective tissue cells gap junction system. In the present investigation, we have shown that intense voltage-gated potassium channel Kv3.1b subunit-like immunoreactivity is found in the type I, type III, and type IV fibrocytes in the spiral ligament. Voltage-gated potassium channel, containing Kv3.1b, in the fibrocytes of the cochlear lateral wall may control the intracellular potential and play an important role in regulating the potassium ion recycling mechanism. Immunohistochemical localizations of inwardly rectifying Kir4.1 potassium channels were also studied in the guinea pig cochlea. Kir4.1 potassium channel in the cochlea may play an important role in the K+ recycling pathway. Further investigations are needed in order to elucidate the detailed potassium ion recycling mechanism in the mammalian inner ear.
正常および難聴モデルマウス内耳の、細胞・細胞外基質間の接合とインテグリンの局在 Competitive

香取幸夫

Offer Organization: 文部科学省

System: 科学研究費補助金奨励研究（Ａ）

2000/04 - 2002/03

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[日本国内] 仙台市青葉保健福祉センター訪問支援講習会

2007/02/07 - Present

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高齢者の嚥下障害・症状、原因、合併症の予防法について
[日本国内] 河北TBCカルチャーセンター講演会

2006/07/20 - Present

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飲み込み（嚥下）のしくみとその障害
[日本国内] 日喉連東北北海道部会発声指導者研修会

2003/10 - Present

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喉頭摘出者の代用音声指導会に定期的に講師として招聘され喉頭摘出者の健康に寄与する講義を行っている。

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高齢者の誤嚥予防に有効な頸部姿勢嚥下内視鏡検査による研究

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喉頭内視鏡と嚥下造影検査により、一側梨状陥凹を食塊が通過する頸部回旋角度を検討し、誤嚥予防の一助とするデータを集積する。