Details of the Researcher

PHOTO

Hiroshi Watabe
Section
Research Center for Accelerator and Radioisotope Science
Job title
Professor
Degree

  • 博士（工学）（東北大学）

  • 修士（工学）（東北大学）

Research History 6

  • 2024/04 - Present
    東北大学先端量子ビーム科学研究センター

  • 2015/04 - 2024/03
    Tohoku University　Cyclotron and Radioisotope Center　Professor

  • 2013/04 - 2015/03
    Tohoku University　Cyclotron and Radioisotope Center　Associate Professor

  • 2009/10 - 2013/03
    Osaka University　Graduate School of Medicine Graduate School of Medicine　Associate Professor

  • 2000/04 - 2009/09
    National Cerebral and Cardiovascular Center, Research Institute

  • 1995/04 - 2000/03
    National Cerebral and Cardiovascular Center, Research Institute

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Education 2

  • Tohoku University　Graduate School of Engineering

    1990/04 - 1995/03

  • Tohoku University　Faculty of Engineering

    1986/04 - 1990/03

Committee Memberships 3

  • 日本放射線安全管理学会　理事

    - Present

  • 大学等放射線施設協議会　理事

    - Present

  • 日本核医学会　理事

Professional Memberships 6

  • Cerebral Blood Flow and Metabolism

  • IEEE

  • 日本核医学学会

  • 医学物理学会

  • 日本分子イメージング学会

  • 日本放射線安全管理学会

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Research Interests 2

  • 核医学物理学

  • Radiation Informatics for Medical Imaging

Research Areas 1

  • Life sciences / Radiology /

Awards 5

  1. 原子力知識・技術の普及貢献賞

    2022/04　日本原子力学会 関東・甲越支部　研究者ネットワーク「Bring」の活動による植物RIイメージング技術の普及

  2. Annals of Nuclear Medicine Frequently Cited Paper 2012

    2013/06　日本核医学会

  3. Invited Lecturer Award

    2009/12　DRD2009

  4. 日本核医学会賞

    2004/11　日本核医学会

  5. 若手研究者に贈られる賞

    1998/06　Neuroreceptor Mapping

Papers 395

  1. RAPTOR-AI: An open-source AI powered radiation protection toolkit for radioisotopes. International-journal

    Hiroshi Watabe, Peter K N Yu, Dragana Krstic, Dragoslav Nikezic, Kyeong Min Kim, Taiga Yamaya, Naoki Kawachi, Hiroki Tanaka, Zoran Jovanovic, A K F Haque, M Rafiqul Islam, Gary Tse, Quinncy Lee, Mehrdad Shahmohammadi Beni

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine　221　111797-111797　2025/07

    DOI： 10.1016/j.apradiso.2025.111797 　

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    Artificial intelligence (AI) has gained significant attention in various scientific fields due to its ability to process large datasets. In nuclear radiation physics, while AI presents exciting opportunities, it cannot replace physics-based models essential for explaining radiation interactions with matter. To combine the strengths of both, we have developed and open-sourced the Radiation Protection Toolkit for Radioisotopes with Artificial Intelligence (RAPTOR-AI). This toolkit integrates AI with the Particle and Heavy Ion Transport code System (PHITS) Monte Carlo package, enabling rapid radiation protection analysis for radioisotopes and structural shielding. RAPTOR-AI is particularly valuable for emergency scenarios, allowing quick dose dispersion assessments when a facility's structural map is available, enhancing safety and response efficiency.

  2. Facile Synthesis of Nanolayered Manganese Oxide for the Efficient and Selective Removal of Strontium(II) from Nuclear Wastewater. International-journal

    Fan Wang, Qi Zheng, Wenya Tai, Qiang Wu, Xinglei Li, Yehuizi Wu, Ningchao Zheng, Shunyan Ning, Deqian Zeng, Hiroshi Watabe, Yan Wu, Hai Li, Yuezhou Wei, Xiangbiao Yin

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)　e17776　2025/06/19

    DOI： 10.1002/advs.202417776 　

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    Efficient and selective removal of radioactive 90Strontium (90Sr) from nuclear wastewater is a sustainable strategy for nuclear energy development and environmental protection due to its long half-life and high biochemical toxicity. Herein, a novel nanolayered manganese oxide material (Na0.7MnO2.05, Na-NLMO) is proposed and its application for Sr(II) capture in both simulated waste liquid and real natural water systems. Na-NLMO is tailored for Sr(II) adsorption through a simple and rapid solid-phase reaction, which has good chemical stability and a strong affinity for Sr(II) across the pH range of 1 to 8. The maximum adsorption capacity is 145.21 mg g-1 taking advantage of the solid-liquid ratio of 0.67 g L-1. The loaded Sr(II) is almost quantitatively recovered by dilute hydrochloric acid solution. Even after 4 adsorption-desorption cycles, it could still effectively adsorb more than 99.9% of Sr(II). Furthermore, the adsorption is unaffected by the excess presence of sodium(I), potassium(I), magnesium(II), and calcium(II). In real-world media such as tap water and river water, its distribution coefficients are 5.2 × 105 and 5.6 × 105 mL g-1, respectively. More importantly, the distribution coefficient toward 90Sr in seawater still achieved 2.5 × 103 mL g-1. The adsorption mechanism of electrostatic interaction and ion exchange is revealed by combining experimental results and spectroscopic analysis, such as Transmission Electron Microscope and X-ray diffraction. The results are expected to provide new insights into the development of innovative and practical technologies for the treatment and disposal of secondary nuclear waste.

  3. The Utility of a Modified Data-Driven Motion Correction Method Incorporating Computed Tomography Positional Data for Positron Emission Tomography.

    Hayato Odagiri, Hiroshi Watabe, Kentaro Takanami, Nao Yamaguchi, Hirofumi Kawakami, Akie Katsuki, Yoshitaka Tanaka, Takashi Takeuchi, Hiroyasu Kodama, Akihito Usui, Kei Takase, Tomohiro Kaneta

    The Tohoku journal of experimental medicine　2025/06/12

    DOI： 10.1620/tjem.2025.J072 　

  4. Synthesis and characterization of functional chitosan-based microspheres as biodegradable yttrium-90 delivery system for radioembolization therapy. International-journal

    Haoyu Zhang, Xiangni Pan, Qiang Wu, Yehuizi Wu, Ningchao Zheng, Shunyan Ning, Deqian Zeng, Lifeng Chen, Wenlong Li, Ji Wang, Tianjiao Jiang, Xizhi Long, Hiroshi Watabe, Hao Wu, Yan Wu, Yuezhou Wei, Xiangbiao Yin

    International journal of biological macromolecules　312　144090-144090　2025/06

    DOI： 10.1016/j.ijbiomac.2025.144090 　

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    Transarterial radioembolization (TARE) using yttrium-90 (90Y)-labeled glass and resin microspheres is an emerging therapeutic technique for hepatocellular carcinoma (HCC). However, the non-biodegradability and rapid settlement of current commercial microspheres might hinder their even distribution and repetitive administration thus causing unsatisfactory therapeutic effects. In this context, novel functional chitosan-based microspheres (CPIs) that can efficiently label Y as a favorable TARE material were developed for the first time by successive grafting poly (glycidyl methacrylate) (PGMA) and iminodiacetic acid (IDA) onto chitosan microspheres (CMs). The results confirmed that the CPIs had desirable spherical shapes with average diameters of around 20.9 μm, an ideal settlement rate within 5 min, and considerable biodegradability at 10th weeks. It reached Y adsorption equilibrium within 30 min and maintained the maximum adsorption capacity up to 14.95 mg g-1 at pH 6.0 following pseudo-second-order kinetic and Langmuir models. Additionally, Y-labeled CPIs were rather stable in vitro, for which Y would firmly interact with the sodium carboxylate group and tertiary amine nitrogen atoms on IDA, and its leakage when shaken in phosphate-buffered saline for 24 h was barely detected. Altogether, these properties of the as-developed CPIs hold great potential as promising radioembolization microspheres for TARE therapy against liver cancer.

  5. Electron and positron scattering by water molecules: cross sections and transport characteristics

    M. Shorifuddoza, Mahmudul H. Khandker, G. B. Ragimkhanov, Z. R. Khalikova, Pretam K. Das, H. Watabe, A. K. Fazlul Haque, M. Alfaz Uddin

    The European Physical Journal D　2025/06

    DOI： 10.1140/epjd/s10053-025-01012-y 　

  6. Efficient isolation of trace radium from bulk thorium using the combination of precipitation and adsorption with a layered ammonium vanadate nanobelt

    Lingyuan Liao, Xuexiang He, Jing Tang, Zhizeng Pan, Yuezhou Wei, Xiangbiao Yin, Wenlong Li, Shunyan Ning, Hiroshi Watabe, Lifeng Chen

    Journal of Environmental Chemical Engineering　2025/04

    DOI： 10.1016/j.jece.2025.115786 　

  7. Uncertainty evaluation in simulation study on range-shift estimation due to statistical noise in secondary electron bremsstrahlung from a small number of carbon ions

    Michiko Tsuda, Mitsutaka Yamaguchi, Yabe Takuya, Yuto Nagao, Naoki Kawachi, Makoto Sakai, Tomihiro Kamiya, Wataru Kada, Hiroshi Watabe

    Japanese Journal of Applied Physics　2025/03/18

    Publisher: IOP Publishing

    DOI： 10.35848/1347-4065/adc21b 　

    ISSN： 0021-4922

    eISSN： 1347-4065

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    Abstract Secondary electron bremsstrahlung (SEB) has been proposed for range verification in particle therapy. However, the uncertainty in the range-shift estimation attributed to high statistical noise from small numbers of carbon-ion irradiation remains unclear. This simulation study evaluated the uncertainty of SEB-based range-shift estimations under conditions of limited numbers of carbon ions. The simulated SEB images were generated by irradiating an acrylic target with monoenergetic carbon-ion beams and calculating the energy deposited onto a cadmium telluride pixel detector. Estimated range shifts were derived from the SEB images using a proposed method, with uncertainties of 1.4 mm for 108 ions and 4.4 mm for 107 ions. The results suggested that improving the detector sensitivity is effective in reducing the uncertainty.

  8. Alpha-particle irradiation effects on weberite-type tantalates for nuclear waste forms

    Chengjie Zhao, Xi Tan, Yue Xia, Min Xu, Qian Liao, Haonan Li, Longcheng Liu, Hiroshi Watabe, Dongyan Yang, Yuhong Li

    Journal of Nuclear Materials　2025/03

    DOI： 10.1016/j.jnucmat.2025.155694 　

  9. Age-related sensitivity deterioration evaluation of positron emission tomography utilizing cross-calibration factor measurement data.

    Asuka Kikuchi, Shoichi Watanuki, Hiroshi Watabe, Manabu Tashiro

    Radiological physics and technology　18　(1)　268-274　2025/02/05

    DOI： 10.1007/s12194-025-00882-6 　

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    Age-related deterioration in positron emission tomography (PET) systems can be monitored using cross-calibration scans for scanner calibration. This study aimed to evaluate changes in the sensitivity of a PET system over time using routinely collected cross-calibration factor (CCF) measurement data and NEMA sensitivity measurement data acquired at our facility. We used CCF measurement data acquired over eight years, from 2016 to 2023. The count rates were calculated from raw data. The NEMA sensitivity measurements were also performed in 2017 and 2024 to compare with the sensitivities obtained from the CCF measurements. The PET images were reconstructed using the CCF data. A region of interest (ROI) was placed at the center of the PET images and count rates from the PET images were obtained. The sensitivity changes in the CCF data showed a linear decrease in sensitivity over eight years, with a mean annual reduction rate of approximately 2.0%. A comparison of the NEMA sensitivity measurements indicated a decrease in sensitivity, with a 12% reduction over eight eight years. The sensitivity was higher at the center of the axial field of view than at the edges. The ROI data also showed a linear decrease in sensitivity. This is consistent with the CCF data. Additionally, the coefficient of variation increased towards the edge of the slice. By utilizing the CCF measurement data, we obtained age-related changes in the PET system, suggesting that the PET system used in our facility may experience an annual sensitivity deterioration of approximately 2.0%.

  10. Imaging of therapeutic carbon-ion beams in a human-head phantom measuring prompt X-rays

    Mitsutaka Yamaguchi, Seiichi Yamamoto, Maki Kitano, Takuya Yabe, Takashi Akagi, Jun Kataoka, Kei Kamada, Akira Yoshikawa, Yuto Nagao, Michiko Tsuda, Hiroshi Watabe, Naoki Kawachi

    Japanese Journal of Applied Physics　64　(2)　027001-027001　2025/02/01

    Publisher: IOP Publishing

    DOI： 10.35848/1347-4065/adae6b 　

    ISSN： 0021-4922

    eISSN： 1347-4065

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    Abstract The purpose of this study is to evaluate the feasibility of monitoring therapeutic carbon-ion beams by measuring prompt X-rays in the clinical application of head treatment. Specifically, we investigated the ability to identify 2 cm differences in beam arrival depth in a head phantom using secondary electron bremsstrahlung. First, a Monte Carlo simulation was conducted. A head phantom was positioned at the center of the simulation space, surrounded by 24 X-ray cameras, and three carbon-ion beams were irradiated. Next, an experimental study was performed using the same beam configuration, with X-ray cameras acquiring images from parietal and temporal-head directions. Simulation results indicated that beam images could be acquired over a wide range of ±135 degrees from the parietal direction, distinguishing 1.8 cm depth differences. Experimentally obtained images were consistent with simulations. These findings suggest that prompt X-ray imaging is a promising tool for monitoring therapeutic carbon-ion beams.

  11. 認知症疾患の層別化における[18F]SMBT-1の有用性の検討プロジェクトの最終報告2024

    田代 学, Wu Yingying, 平岡 宏太良, 冨田 尚希, 小林 良太, Tekea Berihu, 原田 龍一, 菊地 飛鳥, 武田 和子, 草場 美津江, 菊池 昭夫, 古川 勝敏, 渡部 浩司, 麦倉 俊司, 川勝 忍, 石井 賢二, 二橋 尚志, 加藤 隆司, 古本 祥三, 岡村 信行

    Dementia Japan　38　(4)　677-677　2024/10

    Publisher: (一社)日本認知症学会

    ISSN： 1342-646X

  12. Scattering of e∓ in beryllium isonuclear series: cross sections and transport characteristics

    M Shorifuddoza, G B Ragimkhanov, Z R Khalikova, Pretam K Das, H Watabe, A K Fazlul Haque, M Alfaz Uddin

    Physica Scripta　2024/10/01

    DOI： 10.1088/1402-4896/ad71fd 　

  13. Cavity ionization chamber responses in the JAEA and the NMIJ high-energy photon reference fields for radiation protection International-journal

    Junya Ishii, Morihito Shimizu, Masahiro Kato, Tadahiro Kurosawa, Tomoya Tsuji, Hiroshi Yoshitomi, Yoshihiko Tanimura, Hiroshi Watabe

    Journal of Radiological Protection　44　(3)　2024/09/01

    DOI： 10.1088/1361-6498/ad7a07 　

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    A dosimeter should ideally be calibrated in a reference field with similar energy and doserate to that which the dosimeter is being used to measure. Environments around nuclear reactors and radiation therapy facilities have high-energy photons with energies exceeding that of60Co gamma rays, and controlling exposure to these photons is important. The Japan Atomic Energy Agency and National Metrology Institute of Japan have high-energy reference fields with energies above several megaelectronvolts for different types of accelerators. Their reference fields have different fluence-energy distributions. In this study, the energy dependencies of the two-cavity ionization chambers, which are often used by secondary standard laboratories, were experimentally and computationally evaluated for each high-energy field. These results agreed well within the relative expanded uncertainties (k= 2), and their capabilities for air kerma measurements in each high-energy reference field were confirmed. Therefore, the capabilities of the air-kerma measurements were verified in the two high-energy reference fields.

  14. Complexation of 3p-C-NETA with radiometal ions: A density functional theory study for targeted radioimmunotherapy. International-journal

    Danni Ramdhani, Hiroshi Watabe, Ari Hardianto, Regaputra S Janitra

    Heliyon　10　(15)　e34875　2024/08/15

    DOI： 10.1016/j.heliyon.2024.e34875 　

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    Bifunctional chelators (BFCs) are vital in the design of effective radiopharmaceuticals, as they are able to bind to both a radiometal ion and a targeting vector. The 3p-C-NETA or 4-[2-(bis-carboxy-methylamino)-5-(4-nitrophenyl)-entyl])-7-carboxymethyl-[1,4,7]tri-azonan-1-yl acetic acid is a novel and promising BFC, developed for diagnostic and therapeutic purposes. The binding affinity between the BFC and radiometal ion significantly impacts their effectiveness. Predicting the equilibrium constants for the formation of 1:1 radiometals/chelator complexes (log K1 values) is crucial for designing BFCs with improved affinity and selectivity for radiometals. The purpose of this study is to evaluate the complexation of Ga3+, Tb3+, Bi3+, and Ac3+ radiometal ions with 3p-C-NETA using density functional theory (B3LYP and M06-HF functional) and 6-311G(d)/SDD basis sets, where the 1,4,7,10-tetrazacyclodecane-1,4,7,10-tetracetic acid (DOTA) was employed as a benchmark. Formation of the [Ac3+(3p-C-NETA)(H2O)]- complexes is predicted to be markedly less stable compared to the other complexes, exhibiting the lowest chemical hardness and the highest chemical softness. Additionally, the chelation stability of the complexes is mainly determined by ligand-ion and ion-water interactions, which depend on the atomic charge and atomic radius of the metal ion.

  15. Scattering of e ± by H-isonuclear series

    M Mousumi Khatun, M Yousuf Ali, Sk Abdul Kader Arafin, Hiroshi Watabe, A K Fazlul Haque, M Alfaz Uddin

    Physica Scripta　2024/07/01

    DOI： 10.1088/1402-4896/ad5801 　

  16. Monte Carlo modelling of cyclotron and radioisotope center (CYRIC) at Tohoku University: a radiation protection study. International-journal

    Hiroshi Watabe, Peter K N Yu, Gary Tse, Dragana Krstic, Dragoslav Nikezic, M Rafiqul Islam, Zhanbing Wei, Yuezhou Wei, Mehrdad Shahmohammadi Beni

    Journal of radiological protection : official journal of the Society for Radiological Protection　44　(2)　2024/06/13

    DOI： 10.1088/1361-6498/ad5450 　

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    Protection against ionizing radiations is important in laboratories with radioactive materials and high energy cyclotron beams. The Cyclotron and Radioisotope Center (CYRIC) located in Tohoku University in Miyagi prefecture, Japan and is a well-known nuclear science laboratory with cyclotron beams and substantial number of high activity radioactive materials. Considering this, it is important to perform complete radiation transport computations to ensure the safety of non-occupational and occupational workers. In the present work, we have developed a complete 3-dimensional model of the main cyclotron building and radiation labs using Monte Carlo method. We have found that the dispersed photons and neutrons inside and in the surrounding of the CYRIC building pose no significant risk to occupational and non-occupational workers. The present work and the developed models would be useful in the field of radiation protection.

  17. DOCK–PET: database of CNS kinetic parameters in the healthy human brain for existing PET tracers

    Itsuki Miyajima, Ayano Yoshikawa, Kyosei Sahashi, Chie Seki, Yuji Nagai, Hiroshi Watabe, Miho Shidahara

    Annals of Nuclear Medicine　38　(8)　666-672　2024/05/30

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s12149-024-01947-z 　

    ISSN： 0914-7187

    eISSN： 1864-6433

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    PURPOSE: Information about developed positron emission tomography (PET) tracers and obtained clinical PET images is publicly available in a database. However, findings regarding the kinetic parameters of PET tracers are yet to be summarized. Therefore, in this study, we created an open-access database of central nervous system (CNS) kinetic parameters in the healthy human brain for existing PET tracers (DOCK-PET). METHODS: Our database includes information on the kinetic parameters and compounds of existing CNS-PET tracers. The kinetic parameter dataset comprises the analysis methods, VT, BPND, K parameters, relevant literature, and study details. The list of PET tracers and kinetic parameter information was compiled through keyword-based searches of PubMed and the Molecular Imaging and Contrast Agent Database (MICAD). The kinetic parameters obtained, including VT, BPND, and K parameters, were reorganized based on the defined brain anatomical regions. All data were rigorously double-checked before being summarized in Microsoft Excel and JavaScript Object Notation (JSON) formats. RESULTS: Of the 247 PET tracers identified through searches using the PubMed and MICAD websites, the kinetic parameters of 120 PET tracers were available. Among the 120 PET tracers, compound structures with chemical and physical properties were obtained from the PubChem website or the ChemDraw software. Furthermore, the affinity information of the 104 PET tracers was gathered from PubChem or extensive literature surveys of the 120 PET tracers. CONCLUSIONS: We developed a comprehensive open-access database, DOCK-PET, that includes both kinetic parameters of healthy humans and compound information for existing CNS-PET tracers.

  18. Construction and initial performance evaluation of a newly developed plant PET system

    Seiichi Yamamoto, Hiroshi Watabe, Mitsutaka Yamaguchi, Nobuo Suzui, Naoki Kawachi, Jun Kataoka

    Journal of Instrumentation　19　(04)　2024/04/01

    Publisher: IOP Publishing

    DOI： 10.1088/1748-0221/19/04/t04002 　

    ISSN： 1748-0221

  19. Development of a compact multiprobe system for monitoring positron-emitting tracers in plant stems

    Y. Nagao, N. Suzui, Y.-G. Yin, Y. Miyoshi, Y. Noda, K. Enomoto, M. Tsuda, T. Yabe, H. Watabe, M. Yamaguchi, N. Kawachi

    Journal of Instrumentation　2024/04/01

    DOI： 10.1088/1748-0221/19/04/P04023 　

  20. Air kerma reference field with high energy photons using a 15 MeV electron beam from a clinical linear accelerator International-journal

    Junya Ishii, Morihito Shimizu, Masahiro Kato, Tadahiro Kurosawa, Hiroshi Watabe

    Journal of Radiological Protection　44　(1)　2024/03/01

    DOI： 10.1088/1361-6498/ad1fe0 　

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    In the medical and nuclear fields, there are environments where exposure to photons with energies above several MeV can result in problems. The National Metrology Institute of Japan has developed a high-energy photon field using a 15 MeV electron beam of a clinical linear accelerator with a copper target and an aluminium filter unit to facilitate dosimeter calibration in terms of air kerma. To determine the air kerma rate, the energy fluence distribution at a reference point was calculated, and both calculations and experiments evaluated the effective energy and spatial dose distribution. Moreover, to validate the air kerma measurement, two commercial cavity chambers were calibrated in a developed photon field. The results obtained exhibited a 4% difference compared with those in a Co-60γ-ray reference field.

  21. A triple-imaging-modality system for simultaneous measurements of prompt gamma photons, prompt x-rays, and induced positrons during proton beam irradiation International-journal

    Seiichi Yamamoto, Hiroshi Watabe, Kohei Nakanishi, Takuya Yabe, Mitsutaka Yamaguchi, Naoki Kawachi, Kei Kamada, Akira Yoshikawa, Masayasu Miyake, Kazuo S Tanaka, Jun Kataoka

    Physics in Medicine & Biology　69　(5)　055012-055012　2024/02/22

    Publisher: IOP Publishing

    DOI： 10.1088/1361-6560/ad25c6 　

    ISSN： 0031-9155

    eISSN： 1361-6560

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    Abstract Objective. Prompt gamma photon, prompt x-ray, and induced positron imaging are possible methods for observing a proton beam’s shape from outside the subject. However, since these three types of images have not been measured simultaneously nor compared using the same subject, their advantages and disadvantages remain unknown for imaging beam shapes in therapy. To clarify these points, we developed a triple-imaging-modality system to simultaneously measure prompt gamma photons, prompt x-rays, and induced positrons during proton beam irradiation to a phantom. Approach. The developed triple-imaging-modality system consists of a gamma camera, an x-ray camera, and a dual-head positron emission tomography (PET) system. During 80 MeV proton beam irradiation to a polymethyl methacrylate (PMMA) phantom, imaging of prompt gamma photons was conducted by the developed gamma camera from one side of the phantom. Imaging of prompt x-rays was conducted by the developed x-ray camera from the other side. Induced positrons were measured by the developed dual-head PET system set on the upper and lower sides of the phantom. Main results. With the proposed triple-imaging-modality system, we could simultaneously image the prompt gamma photons and prompt x-rays during proton beam irradiation. Induced positron distributions could be measured after the irradiation by the PET system and the gamma camera. Among these imaging modalities, image quality was the best for the induced positrons measured by PET. The estimated ranges were actually similar to those imaged with prompt gamma photons, prompt x-rays and induced positrons measured by PET. Significance. The developed triple-imaging-modality system made possible to simultaneously measure the three different beam images. The system will contribute to increasing the data available for imaging in therapy and will contribute to better estimating the shapes or ranges of proton beam.

  22. The neuromodulatory role of dopamine in improved reaction time by acute cardiovascular exercise. International-journal

    Soichi Ando, Toshihiko Fujimoto, Mizuki Sudo, Shoichi Watanuki, Kotaro Hiraoka, Kazuko Takeda, Yoko Takagi, Daisuke Kitajima, Kodai Mochizuki, Koki Matsuura, Yuki Katagiri, Fairuz Mohd Nasir, Yuchen Lin, Mami Fujibayashi, Joseph T Costello, Terry McMorris, Yoichi Ishikawa, Yoshihito Funaki, Shozo Furumoto, Hiroshi Watabe, Manabu Tashiro

    The Journal of physiology　602　(3)　461-484　2024/01/02

    DOI： 10.1113/JP285173 　

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    Acute cardiovascular physical exercise improves cognitive performance, as evidenced by a reduction in reaction time (RT). However, the mechanistic understanding of how this occurs is elusive and has not been rigorously investigated in humans. Here, using positron emission tomography (PET) with [11 C]raclopride, in a multi-experiment study we investigated whether acute exercise releases endogenous dopamine (DA) in the brain. We hypothesized that acute exercise augments the brain DA system, and that RT improvement is correlated with this endogenous DA release. The PET study (Experiment 1: n = 16) demonstrated that acute physical exercise released endogenous DA, and that endogenous DA release was correlated with improvements in RT of the Go/No-Go task. Thereafter, using two electrical muscle stimulation (EMS) studies (Experiments 2 and 3: n = 18 and 22 respectively), we investigated what triggers RT improvement. The EMS studies indicated that EMS with moderate arm cranking improved RT, but RT was not improved following EMS alone or EMS combined with no load arm cranking. The novel mechanistic findings from these experiments are: (1) endogenous DA appears to be an important neuromodulator for RT improvement and (2) RT is only altered when exercise is associated with central signals from higher brain centres. Our findings explain how humans rapidly alter their behaviour using neuromodulatory systems and have significant implications for promotion of cognitive health. KEY POINTS: Acute cardiovascular exercise improves cognitive performance, as evidenced by a reduction in reaction time (RT). However, the mechanistic understanding of how this occurs is elusive and has not been rigorously investigated in humans. Using the neurochemical specificity of [11 C]raclopride positron emission tomography, we demonstrated that acute supine cycling released endogenous dopamine (DA), and that this release was correlated with improved RT. Additional electrical muscle stimulation studies demonstrated that peripherally driven muscle contractions (i.e. exercise) were insufficient to improve RT. The current study suggests that endogenous DA is an important neuromodulator for RT improvement, and that RT is only altered when exercise is associated with central signals from higher brain centres.

  23. 神経炎症イメージングのためのPET薬剤[18F]SMBT-1の動態解析

    平岡 宏太良, Mesfin Berihu, 菊地 飛鳥, 船木 善仁, 原田 龍一, 石木 愛子, 古本 祥三, 岡村 信行, 菊池 昭夫, 渡部 浩司, 田代 学

    核医学　61　(Suppl.)　S153-S153　2024

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  24. C-14線源由来の制動放射線測定による植物モニタリング手法の開発—【※】若手優秀講演賞エントリー

    津田 路子, 山口 充孝, 鈴井 伸郎, 尹 永根, 三好 悠太, 長尾 悠人, 矢部 卓也, 野田 祐作, 榎本 一之, 河地 有木, 古川 純, 毛呂 太陽, 佐藤 史弥, 神谷 富裕, 渡部 浩司

    アイソトープ・放射線研究発表会　4　102　2024

    Publisher: 公益社団法人 日本アイソトープ協会

    DOI： 10.50955/happyokai.4.0_102 　

    eISSN： 2436-4487

  25. Verification of the effect of data-driven brain motion correction on PET imaging. International-journal

    Hayato Odagiri, Hiroshi Watabe, Kentaro Takanami, Kazuma Akimoto, Akihito Usui, Hirofumi Kawakami, Akie Katsuki, Nozomu Uetake, Yutaka Dendo, Yoshitaka Tanaka, Hiroyasu Kodama, Kei Takase, Tomohiro Kaneta

    PloS one　19　(7)　e0301919　2024

    DOI： 10.1371/journal.pone.0301919 　

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    INTRODUCTION: Brain positron emission tomography/computed tomography (PET/CT) scans are useful for identifying the cause of dementia by evaluating glucose metabolism in the brain with F-18-fluorodeoxyglucose or Aβ deposition with F-18-florbetaben. However, since imaging time ranges from 10 to 30 minutes, movements during the examination might result in image artifacts, which interfere with diagnosis. To solve this problem, data-driven brain motion correction (DDBMC) techniques are capable of performing motion corrected reconstruction using highly accurate motion estimates with high temporal resolution. In this study, we investigated the effectiveness of DDBMC techniques on PET/CT images using a Hoffman phantom, involving continuous rotational and tilting motion, each expanded up to approximately 20 degrees. MATERIALS AND METHODS: Listmode imaging was performed using a Hoffman phantom that reproduced rotational and tilting motions of the head. Brain motion correction processing was performed on the obtained data. Reconstructed images with and without brain motion correction processing were compared. Visual evaluations by a nuclear medicine specialist and quantitative parameters of images with correction and reference still images were compared. RESULTS: Normalized Mean Squared Error (NMSE) results demonstrated the effectiveness of DDBMC in compensating for rotational and tilting motions during PET imaging. In Cases 1 and 2 involving rotational motion, NMSE decreased from 0.15-0.2 to approximately 0.01 with DDBMC, indicating a substantial reduction in differences from the reference image across various brain regions. In the Structural Similarity Index (SSIM), DDBMC improved it to above 0.96 Contrast assessment revealed notable improvements with DDBMC. In continuous rotational motion, % contrast increased from 42.4% to 73.5%, In tilting motion, % contrast increased from 52.3% to 64.5%, eliminating significant differences from the static reference image. These findings underscore the efficacy of DDBMC in enhancing image contrast and minimizing motion induced variations across different motion scenarios. CONCLUSIONS: DDBMC processing can effectively compensate for continuous rotational and tilting motion of the head during PET, with motion angles of approximately 20 degrees. However, a significant limitation of this study is the exclusive validation of the proposed method using a Hoffman phantom; its applicability to the human brain has not been investigated. Further research involving human subjects is necessary to assess the generalizability and reliability of the presented motion correction technique in real clinical scenarios.

  26. A large field-of-view angled panel detector for the development of a plant PET system Peer-reviewed

    Seiichi Yamamoto, Hiroshi Watabe, Mitsutaka Yamaguchi, Nobuo Suzui, Naoki Kawachi, Jun Kataoka

    Journal of Instrumentation　19　(1)　T01002　2024/01/01

    DOI： 10.1088/1748-0221/19/01/t01002 　

    ISSN： 1748-0221

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    <jats:title>Abstract</jats:title> <jats:p>In plant research, positron emission tomography (PET) is sometimes employed for physiological studies of plants. However, due to the generally high cost of PET systems, their application in plant research centers can be challenging. Furthermore, the configurations of commercial PET systems might not always align well with the requirements of plant research. To address these issues, we have taken the initial steps towards a solution by developing a large field-of-view (LFOV) angled panel detector intended for the development of a plant PET system. This panel detector is composed of two gadolinium orthosilicate (GSO) scintillator blocks, an angled light guide, and four flat panel photomultiplier tubes (FP-PMTs). The GSO pixel size used in the scintillator block measures 2.65 mm (radial)× 2.85 mm (axial)× 15.0 mm, arranged in a configuration of 16 (radial)× 32 (axial) to form a scintillator block with overall dimensions of 44.0 mm (radial)× 94.4 mm (axial)× 15 mm (depth). By implementing an angled light guide, the two scintillator blocks were positioned at a 22.5-degree angle, resulting in the creation of a LFOV angled panel detector. This specific angle allowed for the arrangement of 16 scintillator blocks in a hexadecagonal shape using 8 panel detectors when arranged in a circular configuration. We successfully constructed a panel detector with an approximate field-of-view of 10 cm× 10 cm and conducted a comprehensive performance evaluation. Upon irradiating the panel detector with 511 keV gamma photons, nearly all 1024 GSO pixels were accurately resolved in the position histogram, displaying minimal distortion, and exhibiting an average peak-to-valley ratio of 5.0. Additionally, the energy resolution achieved was 14% full width at half maximum (FWHM). The resulting LFOV angled panel detector holds considerable promise for the use within a cost-effective, user-friendly as well as high performance plant PET system.</jats:p>

  27. Production of Auger-electron-emitting 103mRh via a 103Pd/103mRh generator using an anion-exchange resin

    Tomoyuki Ohya, Jun Ichinose, Kotaro Nagatsu, Yumi Sugo, Noriko Ishioka, Hiroshi Watabe, Masatoshi Itoh, Katsuyuki Minegishi, Ming-Rong Zhang

    Radiochimica Acta　112　(1)　37-43　2023/11/24

    Publisher: Walter de Gruyter GmbH

    DOI： 10.1515/ract-2023-0238 　

    ISSN： 0033-8230

    eISSN： 2193-3405

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    Abstract Rhodium-103m is one of the most attractive Auger electron emitters for internal radiotherapy. The half-life of 103mRh is relatively short (56.114 min). Therefore, it needs to be produced using a generator for clinical use. Most studies of 103Pd/103mRh generators using anion-exchange resins were carried out over 50 years ago. However, these resins are no longer commercially available. In the present study, we tested a 103Pd/103mRh generator using alternative anion-exchange resins (i.e., IRA904, IRA410, SA20A, and SA11AL). No-carrier-added 103Pd was used to make the generators. The 103mRh product was eluted from the generators using 6 mL of 0.1 M HCl with a flow rate 0.5 mL/min. The generator made from SA11AL showed good performance, with a yield of 39 %, an impurity level of 103Pd in the product of 0.29 %, and an operation time of 14 min. This makes this generator competitive with previously developed ones.

  28. Development of DynamicMC for PHITS Monte Carlo package International-journal

    Hiroshi Watabe, Tatsuhiko Sato, Kwan Ngok Yu, Milena Zivkovic, Dragana Krstic, Dragoslav Nikezic, Kyeong Min Kim, Taiga Yamaya, Naoki Kawachi, Hiroki Tanaka, A K F Haque, M Rafiqul Islam, Mehrdad Shahmohammadi Beni

    Radiation Protection Dosimetry　200　(2)　130-142　2023/11/13

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/rpd/ncad278 　

    ISSN： 0144-8420

    eISSN： 1742-3406

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    Abstract Previously, we have developed DynamicMC for modeling relative movement of Oak Ridge National Laboratory phantom in a radiation field for the Monte Carlo N-Particle package (Health Physics. 2023,124(4):301–309). Using this software, three-dimensional dose distributions in a phantom irradiated by a certain mono-energetic (Mono E) source can be deduced through its graphical user interface. In this study, we extended DynamicMC to be used in combination with the Particle and Heavy Ion Transport code System (PHITS) by providing it with a higher flexibility for dynamic movement for an anthropomorphic phantom. For this purpose, we implemented four new functions into the software, which are (1) to generate not only Mono E sources but also those having an energy spectrum of an arbitrary radioisotope (2) to calculate the absorbed doses for several radiologically important organs (3) to automatically average the calculated absorbed doses along the path of the phantom and (4) to generate user-defined slab shielding materials. The first and third items utilize the PHITS-specific modalities named radioisotope-source and sumtally functions, respectively. The computational cost and complexity can be dramatically reduced with these features. We anticipate that the present work and the developed open-source tools will be in the interest of nuclear radiation physics community for research and teaching purposes.

  29. Simulation evaluation of uncertainty of estimated ranges for therapeutic carbon-ion beams bymeasuring secondary electron bremsstrahlung

    M. Tsuda, M. Yamaguchi, T. Yabe, Y. Nagao, N. Kawachi, M. Sakai, T. Kamiya, H. Watabe

    2023 IEEE Nuclear Science Symposium, Medical Imaging Conference and International Symposium on Room-Temperature Semiconductor Detectors (NSS MIC RTSD)　1-1　2023/11/04

    Publisher: IEEE

    DOI： 10.1109/nssmicrtsd49126.2023.10338039 　

  30. Positron annihilation lifetime measurement with TOF-PET detectors: feasibility of Iodine-124 use

    Sodai Takyu, Hayato Ikeda, Hidekatsu Wakizaka, Fumihiko Nishikido, Ken-ichiro Matsumoto, Hideaki Tashima, Hisashi Suzuki, Yoshihito Funaki, Hiroshi Watabe, Miwako Takahashi, Taiga Yamaya

    Applied Physics Express　16　(11)　116001-116001　2023/11/01

    Publisher: IOP Publishing

    DOI： 10.35848/1882-0786/ad047c 　

    ISSN： 1882-0778

    eISSN： 1882-0786

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    Abstract Positronium (Ps) imaging is getting attention for nuclear medicine applications, but appropriate radionuclides have not been evaluated systematically. This paper investigated the use of 124I, which is a positron emitter with 603 keV prompt gamma ray emission with a fraction of 11.7%. The accuracy of positron annihilation lifetime measurement with 124I was compared with 22Na, which is often used in positron annihilation lifetime measurement, for certified reference materials. Results obtained with TOF-PET detectors suggested that the accuracy of the lifetime value estimation was slightly worse than that for 22Na, while the positron annihilation lifetime measurement using 124I was a feasible choice.

  31. Scattering of e$$^\pm $$ by silicon atoms and transport coefficients in mixtures of inert gas with silicon vapor

    Pretam K. Das, G. B. Ragimkhanov, Z. R. Khalikova, M. Shorifuddoza, M. Moniruddoza Ashir, Joydeb Barman, Hiroshi Watabe, A. K. Fazlul Haque, M. Alfaz Uddin

    The European Physical Journal D　2023/09

    DOI： 10.1140/epjd/s10053-023-00746-x 　

  32. Hybrid imaging of prompt x-rays and induced positrons using a pinhole gamma camera during and after irradiation of protons. International-journal

    Seiichi Yamamoto, Hiroshi Watabe, Kohei Nakanishi, Takuya Yabe, Mitsutaka Yamaguchi, Naoki Kawachi, Kei Kamada, Akira Yoshikawa, Md Rafiqul Islam, Masayasu Miyake, Kazuo S Tanaka, Jun Kataoka

    Physics in medicine and biology　68　(11)　2023/05/30

    DOI： 10.1088/1361-6560/acd2a2 　

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    Objective. Prompt x-ray imaging using a low-energy x-ray camera is a promising method for observing a proton beam's shape from outside the subject. Furthermore, imaging of positrons produced by nuclear reactions with protons is a possible method for observing the beam shape. However, it has not been possible to measure these two types of images with a single imaging system due to the limited imaging capability of existing systems. Imaging of both prompt x-rays and the distribution of positrons may compensate for the shortcomings of each method.Approach. We conducted imaging of the prompt x-ray using a pinhole x-ray camera during irradiation with protons in list mode. Then, after irradiation with protons, imaging of annihilation radiations from the produced positrons was conducted using the same pinhole x-ray camera in list mode. After this imaging, list-mode data were sorted to obtain prompt x-ray images and positron images.Main results. With the proposed procedure, we could measure both prompt x-ray images and induced positron images with a single irradiation by a proton beam. From the prompt x-ray images, ranges and widths of the proton beams could be estimated. The distributions of positrons were slightly wider than those of the prompt x-rays. From the time sequential positron images, we could derive the time activity curves of the produced positrons.Significance. Hybrid imaging of prompt x-rays and induced positrons using a pinhole x-ray camera was achieved. The proposed procedure would be useful for measuring prompt x-ray images during irradiation to estimate the beam structures as well as for measuring the induced positron images after irradiation to estimate the distributions and time activity curves of the induced positrons.

  33. DynamicMC: An Open-source GUI Program Coupled with MCNP for Modeling Relative Dynamic Movement of Radioactive Source and ORNL Phantom in a 3-dimensional Radiation Field. International-journal

    Kwan Ngok Yu, Hiroshi Watabe, Milena Zivkovic, Dragana Krstic, Dragoslav Nikezic, Kyeong Min Kim, Taiga Yamaya, Naoki Kawachi, Hiroki Tanaka, A K F Haque, Mehrdad Shahmohammadi Beni

    Health physics　124　(4)　301-309　2023/04/01

    DOI： 10.1097/HP.0000000000001670 　

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    The present work introduces an open-source graphical user interface (GUI) computer program called DynamicMC. The present program has the ability to generate ORNL phantom input script for the Monte Carlo N-Particle (MCNP) package. The relative dynamic movement of the radiation source with respect to the ORNL phantom can be modeled, which essentially resembles the dynamic movement of source-to-target (i.e., human phantom) distance in a 3-dimensional radiation field. The present program makes the organ-based dosimetry of the human body much easier, as users are not required to write lengthy scripts or deal with any programming that many may find tedious, time consuming, and error prone. In this paper, we have demonstrated that the present program can successfully model simple and complex relative dynamic movements (i.e., those involving rotation of source and human phantom in a 3-dimensional field). The present program would be useful for organ-based dosimetry and could also be used as a tool for teaching nuclear radiation physics and its interaction with the human body.

  34. ピンホール径の大きいX線カメラによる二次電子制動放射測定による治療用炭素イオンビームのrange-estimation uncertaintyのシミュレーション評価(Simulation Evaluation of Range-estimation Uncertainty for Therapeutic Carbon-ion Beams by Measuring Secondary Electron Bremsstrahlung with a Large-pinhole X-ray Camera)

    Tsuda Michiko, Yamaguchi Mitsutaka, Yabe Takuya, Nagao Yuto, Kawachi Naoki, Watabe Hiroshi, Kamiya Tomihiro

    日本放射線技術学会総会学術大会予稿集　79回　331-331　2023/03

    Publisher: (公社)日本放射線技術学会

    ISSN： 1884-7846

  35. A Theoretical Study of Scattering of e± by Tl Atom

    Sunzida Parvin, Md. Masum Billah, Mahmudul H Khandker, M. Ismail Hossain, Md. Monirul Haque, Mehrdad Shahmohammadi Beni, Hiroshi Watabe, Abul Kalam Fazlul Haque, M. Alfaz Uddin

    Atoms　2023/02/10

    DOI： 10.3390/atoms11020037 　

  36. Estrogen receptor targeting with genistein radiolabeled Technetium-99m as radiotracer of breast cancer: Its optimization, characterization, and predicting stability constants by DFT calculation. International-journal

    Danni Ramdhani, Nita Listiani, Maula Eka Sriyani, Eva Maria W, Hiroshi Watabe, Resmi Mustarichie, Sri Agung Fitri Kusuma, Regaputra S Janitra

    Heliyon　9　(2)　e13169　2023/02

    DOI： 10.1016/j.heliyon.2023.e13169 　

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    OBJECTIVE: Genistein is an isoflavone molecule with a high affinity for estrogen receptors (ER), which could lead to the mechanism of selective estrogen receptor modulators (SERMs) in breast cancer. Genistein labeling with technetium-99m can be a new promising strategy for diagnostic breast cancer. In this research, we evaluate the physicochemical characteristics of the [99mTc]Tc-genistein complex and describe the optimal labeling method parameters. We also calculated density functional theory to study the stability constants to support complex formation analysis (DFT). METHODS: The genistein was directly labeled with 99mTc, and its stability as well as its potential for usage as a radiotracer were all investigated. DFT calculations with thermodynamic cycles to determine chemical coordination models and calculate thermodynamic constants of complex more accurately. RESULTS: The radiochemical purity of [99mTc]Tc-genistein showed a high yield of 93.25% ± 0.30% and had good physicochemical properties. The stability of the Tc(IV)-genistein complex was confirmed by DFT calculations at a value of 99.0822. CONCLUSIONS: As a result, [99mTc]Tc-genistein could be a potential radiotracer kit for SPECT imaging of breast cancer.

  37. Scattering of e± by C2H6 Molecule over a Wide Range of Energy: A Theoretical Investigation. International-journal

    N M B Sathee, M Mousumi Khatun, Anita Rani, M Masum Billah, M Nure Alam Abdullah, Mahmudul H Khandker, Hiroshi Watabe, A K Fazlul Haque, M Alfaz Uddin

    Molecules (Basel, Switzerland)　28　(3)　2023/01/27

    DOI： 10.3390/molecules28031255 　

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    The present work reports the theoretical investigation of the scattering of electrons and positrons by the ethane (C2H6) molecule over the energy range 1 eV-1 MeV. The investigation was carried out by taking into account the screening correction arising from a semiclassical analysis of the atomic geometrical overlapping of the scattering observables calculated in the independent atom approximation. The study is presented through the calculations of a broad spectrum of observable quantities, namely differential, integrated elastic, momentum transfer, viscosity, inelastic, grand total, and total ionization cross-sections and the Sherman functions. A comparative study was carried out between scattering observables for electron impact with those for positron impact to exhibit the similarity and dissimilarity arising out of the difference of the collisions of impinging projectiles with the target. Partial-wave decomposition of the scattering states within the Dirac relativistic framework employing a free-atom complex optical model potential was used to calculate the corresponding observable quantities of the constituent atoms. The results, calculated using our recipe, were compared with the experimental and theoretical works available in the literature. The Sherman function for a e±-C2H6 scattering system is presented for the first time in the literature. The addition of the screening correction to the independent atom approximation method was found to substantially reduce the scattering cross-sections, particularly at forward angles for lower incident energies.

  38. Evaluation and optimization of geometry parameters of GAGG scintillator-based Compton Camera for medical imaging by Monte Carlo simulation

    H. Zarei, S. Razaghi, Y. Nagao, M. Itoh, M. Yamaguchi, N. Kawachi, M.R. Ay, H. Watabe

    Journal of Instrumentation　18　(01)　P01035-P01035　2023/01/01

    Publisher: IOP Publishing

    DOI： 10.1088/1748-0221/18/01/p01035 　

    eISSN： 1748-0221

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    Abstract In nuclear medicine, the development of portable imaging devices that provide high imaging resolution and sensitivity, capable of imaging gamma rays with a wide energy range and multiple radioisotopes tracing capabilities, is so important. These goals have been possible thanks to developing a compact Compton camera, a collimatorless detector coupled to compact silicon photomultiplier(SiPM) array, using scintillator crystal. In this study, the portable segmented GAGG:Ce scintillator-based Compton camera (CC) is optimized with the GATE, a Monte Carlo simulation toolkit based on Geant4, to maximize its performance for a wide range of gamma-ray energy (364–1000 keV). The geometrical parameters are selected as optimization parameters to investigate their effects on CC's performance, including imaging resolution and absolute detection efficiency (DEa). The geometry parameters of CC include the planner area of scatterer and absorber detectors, their thicknesses, and the distance between them. The results for the energy range of 364–1000 keV show that the most important contributions to the spatial resolution and DEa of the camera are SAD (scatterer to absorber distance) and the scatterer area while changing absorber area (AA) showed the most negligible impact. In the short SADs, imaging resolution and DEa are significantly affected by the detector's size and thickness. On the other hand, in the long SADs (&gt; 4 cm), both spatial resolution and DEa are significantly affected by the detector's area but less affected by the detector's thickness. Decreasing the scatterer's thickness and the absorber's size or thickness improves imaging resolution without significantly reducing DEa. The simulation study's findings presented here will provide valuable guidelines for researchers choosing a desired CC's design according to particular objectives, manufacturing limitations in scintillator growth, cost, etc.

  39. Simulation study on carbon-ion beam imaging by measuring secondary electron bremsstrahlung using imaging plate

    M. Tsuda, M. Yamaguchi, W. Kada, T. Kamiya, M. Sakai, H. Watabe, Y. Nagao, T. Yabe, N. Kawachi

    Journal of Instrumentation　18　(01)　C01071-C01071　2023/01/01

    Publisher: IOP Publishing

    DOI： 10.1088/1748-0221/18/01/c01071 　

    eISSN： 1748-0221

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    Abstract The purpose of this study is to evaluate the effect of a lead radiation shield on the ability of a beam imaging device consist of an imaging plate (IP) and a collimator by Monte Carlo simulations. Simulations were performed using PHITS. A carbon-ion beam was injected to an acrylic target. A tungsten collimator having a pinhole was placed at the distance of 31.2 cm from the beam. A lead radiation shield was placed on the tungsten collimator. An IP was placed under the collimator. Beam images were acquired by recording the position distribution of energy deposition on the IP. We confirmed that therapeutic carbon-ion beam images could be acquired using the imaging device combining the IP and collimator. It was found that removal of the lead shield had no effect on the imaging results.

  40. Development of an open-source GUI computer program for modelling irradiation of multi-segmented phantoms using grid-based system for PHITS

    Hiroshi Watabe, Kwan Ngok Yu, Nursel Safakatti, Mehrdad Shahmohammadi Beni

    Nuclear Engineering and Technology　2023/01

    DOI： 10.1016/j.net.2022.08.033 　

  41. Scattering of electrons and positrons from aluminum isonuclear series

    M Raihan Islam, A K F Haque, M M Haque, M Masum Billah, Mahmudul H Khandker, M Rafiqul Islam, Hiroshi Watabe, M Alfaz Uddin

    Physica Scripta　2022/12/01

    DOI： 10.1088/1402-4896/ac9865 　

  42. 認知症疾患の層別化における[18F]SMBT-1の有用性の検討プロジェクトの経過報告2022

    田代 学, 平岡 宏太良, 冨田 尚希, 石木 愛子, 小林 良太, 四月朔日 聖一, メスフィン・ベリフ, 武田 和子, 草場 美津江, 菊池 昭夫, 渡部 浩司, 麦倉 俊司, 古川 勝敏, 加藤 隆司, 石井 賢二, 川勝 忍, 原田 龍一, 古本 祥三, 岡村 信行

    老年精神医学雑誌　33　(増刊II)　341-341　2022/11

    Publisher: (株)ワールドプランニング

    ISSN： 0915-6305

  43. 認知症疾患の層別化における[18F]SMBT-1の有用性の検討プロジェクトの経過報告2022

    田代 学, 平岡 宏太良, 冨田 尚希, 石木 愛子, 小林 良太, 四月朔日 聖一, メスフィン・ベリフ, 武田 和子, 草場 美津江, 菊池 昭夫, 渡部 浩司, 麦倉 俊司, 古川 勝敏, 加藤 隆司, 石井 賢二, 川勝 忍, 原田 龍一, 古本 祥三, 岡村 信行

    老年精神医学雑誌　33　(増刊II)　341-341　2022/11

    Publisher: (株)ワールドプランニング

    ISSN： 0915-6305

  44. On the effectiveness of proton boron fusion therapy (PBFT) at cellular level. International-journal

    Mehrdad Shahmohammadi Beni, M Rafiqul Islam, Kyeong Min Kim, Dragana Krstic, Dragoslav Nikezic, Kwan Ngok Yu, Hiroshi Watabe

    Scientific reports　12　(1)　18098-18098　2022/10/27

    DOI： 10.1038/s41598-022-23077-0 　

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    The present work introduced a framework to investigate the effectiveness of proton boron fusion therapy (PBFT) at the cellular level. The framework consisted of a cell array generator program coupled with PHITS Monte Carlo package with a dedicated terminal-based code editor that was developed in this work. The framework enabled users to model large cell arrays with normal, all boron, and random boron filled cytoplasm, to investigate the underlying mechanism of PBFT. It was found that alpha particles and neutrons could be produced in absence of boron mainly because of nuclear reaction induced by proton interaction with 16O, 12C and 14N nuclei. The effectiveness of PBFT is highly dependent on the incident proton energy, source size, cell array size, buffer medium thickness layer, concentration and distribution of boron in the cell array. To quantitatively assess the effectiveness of PBFT, of the total energy deposition by alpha particle for different cases were determined. The number of alpha particle hits in cell cytoplasm and nucleus for normal and 100 ppm boron were determined. The obtained results and the developed tools would be useful for future development of PBFT to objectively determine the effectiveness of this treatment modality.

  45. The performance study of developed cost-effective Compton Camera based on Ce:GAGG scintillator using experimental measurements and CCMod of GATE simulation module

    Hajar Zarei, Yuto Nagao, Kohei Yamamoto, Masatoshi Itoh, Mitsutaka Yamaguchi, Naoki Kawachi, Hiroshi Watabe

    Journal of Instrumentation　17　(10)　P10012-P10012　2022/10/01

    Publisher: IOP Publishing

    DOI： 10.1088/1748-0221/17/10/p10012 　

    eISSN： 1748-0221

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    Abstract In our previous work, a cost-effective Compton camera (CC) using Ce doped Gd3(Al,Ga)5O12(Ce:GAGG) scintillator consisting of two detectors, scatterer (20.8 × 20.8 × 5 mm3) and absorber (41.7 × 41.7 × 10 mm3), was developed to image gamma rays having energy more than 511 keV. This study fabricated a newly developed CC with a larger scatterer and thinner absorber. The system consists of two detectors: a scatterer and an absorber of Ce:GAGG scintillator. The size of the scatterer and absorber is the same; a 40-mm × 40-mm × 5-mm array block consists of 40 × 40 pixels. The size of each scintillator pixel is 0.85 mm × 0.85 mm for both systems. Imaging experiments of Na-22 and Cs-137 point sources were performed to investigate the imaging capability of the new camera, and then the obtained data were compared to the previous CC. The current CC's absolute detection efficiency (DEa) and photopeak detection efficiency (DEp) are improved by 1.6 and 2 times greater than the previous one. At the same time, both systems' spatial and angular resolutions are almost the same value at 511 keV. The Compton camera module (CCMod) in GATE v9.0 was employed for Monte Carlo simulations to reproduce the experimental data showing a good agreement.

  46. A Feasibility Study on Proton Range Monitoring Using 13N Peak in Inhomogeneous Targets. International-journal

    Md Rafiqul Islam, Mehrdad Shahmohammadi Beni, Akihito Inamura, Nursel Şafakattı, Masayasu Miyake, Mahabubur Rahman, Abul Kalam Fazlul Haque, Shigeki Ito, Shinichi Gotoh, Taiga Yamaya, Hiroshi Watabe

    Tomography (Ann Arbor, Mich.)　8　(5)　2313-2329　2022/09/15

    DOI： 10.3390/tomography8050193 　

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    Proton irradiations are highly sensitive to spatial variations, mainly due to their high linear energy transfer (LET) and densely ionizing nature. In realistic clinical applications, the targets of ionizing radiation are inhomogeneous in terms of geometry and chemical composition (i.e., organs in the human body). One of the main methods for proton range monitoring is to utilize the production of proton induced positron emitting radionuclides; these could be measured precisely with positron emission tomography (PET) systems. One main positron emitting radionuclide that could be used for proton range monitoring and verification was found to be 13N that produces a peak close to the Bragg peak. In the present work, we have employed the Monte Carlo method and Spectral Analysis (SA) technique to investigate the feasibility of utilizing the 13N peak for proton range monitoring and verification in inhomogeneous targets. Two different phantom types, namely, (1) ordinary slab and (2) MIRD anthropomorphic phantoms, were used. We have found that the generated 13N peak in such highly inhomogeneous targets (ordinary slab and human phantom) is close to the actual Bragg peak, when irradiated by incident proton beam. The feasibility of using the SA technique to estimate the distribution of positron emitter was also investigated. The current findings and the developed tools in the present work would be helpful in proton range monitoring and verification in realistic clinical radiation therapy using proton beams.

  47. Scattering of e± from CF3I Molecule

    Mahmudul H. Khandker, M. Mousumi Khatun, M. Masum Billah, M. M. Haque, Hiroshi Watabe, A. K. Fazlul Haque, M. Alfaz Uddin

    Atoms　2022/08/24

    DOI： 10.3390/atoms10030085 　

  48. Theoretical study of e±-NH3 scattering

    Nira Akter, M. Nure Alam Abdullah, M. Shorifuddoza, M. Atiqur R. Patoary, M. Masum Billah, Mahmudul H. Khandker, M. Maaza, Hiroshi Watabe, A. K. F. Haque, M Alfaz Uddin

    Molecular Physics　29　104742-104742　2022/07/03

    Publisher: Informa {UK} Limited

    DOI： 10.1080/00268976.2022.2097135 　

    ISSN： 2211-3797

  49. Anatomical variability, multi-modal coordinate systems, and precision targeting in the marmoset brain. International-journal

    Takayuki Ose, Joonas A Autio, Masahiro Ohno, Stephen Frey, Akiko Uematsu, Akihiro Kawasaki, Chiho Takeda, Yuki Hori, Kantaro Nishigori, Tomokazu Nakako, Chihiro Yokoyama, Hidetaka Nagata, Tetsuo Yamamori, David C Van Essen, Matthew F Glasser, Hiroshi Watabe, Takuya Hayashi

    NeuroImage　250　118965-118965　2022/04/15

    DOI： 10.1016/j.neuroimage.2022.118965 　

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    Localising accurate brain regions needs careful evaluation in each experimental species due to their individual variability. However, the function and connectivity of brain areas is commonly studied using a single-subject cranial landmark-based stereotactic atlas in animal neuroscience. Here, we address this issue in a small primate, the common marmoset, which is increasingly widely used in systems neuroscience. We developed a non-invasive multi-modal neuroimaging-based targeting pipeline, which accounts for intersubject anatomical variability in cranial and cortical landmarks in marmosets. This methodology allowed creation of multi-modal templates (MarmosetRIKEN20) including head CT and brain MR images, embedded in coordinate systems of anterior and posterior commissures (AC-PC) and CIFTI grayordinates. We found that the horizontal plane of the stereotactic coordinate was significantly rotated in pitch relative to the AC-PC coordinate system (10 degrees, frontal downwards), and had a significant bias and uncertainty due to positioning procedures. We also found that many common cranial and brain landmarks (e.g., bregma, intraparietal sulcus) vary in location across subjects and are substantial relative to average marmoset cortical area dimensions. Combining the neuroimaging-based targeting pipeline with robot-guided surgery enabled proof-of-concept targeting of deep brain structures with an accuracy of 0.2 mm. Altogether, our findings demonstrate substantial intersubject variability in marmoset brain and cranial landmarks, implying that subject-specific neuroimaging-based localization is needed for precision targeting in marmosets. The population-based templates and atlases in grayordinates, created for the first time in marmoset monkeys, should help bridging between macroscale and microscale analyses.

  50. Development of PHITS graphical user interface for simulation of positron emitting radioisotopes production in common biological materials during proton therapy. International-journal

    Mehrdad Shahmohammadi Beni, Kwan Ngok Yu, M Rafiqul Islam, Hiroshi Watabe

    Journal of radiation research　63　(3)　385-392　2022/03/28

    DOI： 10.1093/jrr/rrac010 　

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    The Monte Carlo (MC) method is a powerful tool for modeling nuclear radiation interaction with matter. A variety of MC software packages has been developed, especially for applications in radiation therapy. Most widely used MC packages require users to write their own input scripts for their systems, which can be a time consuming and error prone process and requires extensive user experience. In the present work, we have developed a graphical user interface (GUI) bundled with a custom-made 3D OpenGL visualizer for PHITS MC package. The current version focuses on modeling proton induced positron emitting radioisotopes, which in turn can be used for verification of proton ranges in proton therapy. The developed GUI program does not require extensive user experience. The present open-source program is distributed under GPLv3 license that allows users to freely download, modify, recompile and redistribute the program.

  51. A Theoretical Study of Scattering of Electrons and Positrons by CO2 Molecule

    M. Masum Billah, M. Mousumi Khatun, M. M. Haque, M. Yousuf Ali, Mahmudul H. Khandker, A. K. F. Haque, Hiroshi Watabe, M. Alfaz Uddin

    Atoms　10　(1)　31-31　2022/03/09

    Publisher: {MDPI} {AG}

    DOI： 10.3390/atoms10010031 　

  52. Noninvasive estimation of human radiation dosimetry of 18F-FDG by whole-body small animal PET imaging in rats. International-journal

    Miho Shidahara, Yoshihito Funaki, Hiroshi Watabe

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine　181　110071-110071　2022/03

    Publisher: Elsevier {BV}

    DOI： 10.1016/j.apradiso.2021.110071 　

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    PURPOSE: Small animal PET provides the biodistribution of administrated radiotracer in vivo and have a potential to contribute on dosimetry study. The aim of this study is to investigate the effect of region-of-interest (ROI)-delineation in whole-body rat PET image toward non-invasive estimation of human dosimetry of 18F-FDG. METHOD: After administration of 18F-FDG (averaged 11.7 MBq), 3.5-h PET and 20-min CT scans were sequentially performed for three rats by Clairvivo PET/CT system. Seven source organs, and the remainder of the body, were studied to extrapolate %ID(t) and estimate time-integrated activity coefficients [kBq-h/MBq] in human. The mean absorbed dose in each target organ and the effective dose were estimated by MIRD method. Effects of ROI-definitions on both extrapolated %ID(t) in human and estimated doses were also investigated by using (i) small ROIs of high uptake region and (ii) whole organ ROIs. RESULTS: Averaged effective doses of 18F-FDG in human by using high-uptake and whole-organ ROIs were 27.8 ± 6.54 and 19.3 ± 2.72 μSv/MBq, respectively. CONCLUSION: The use of small animal PET scanner, which allows repeatedly PET scans, have a potential to contribute on the reduction of the number of experimental animals. However, the ways of ROI drawing influences on the estimated effective dose and safe-side ROI definition may be preferred.

  53. Role of nanoparticles in transarterial radioembolization with glass microspheres.

    Asra Sadat Talebi, Hossein Rajabi, Hiroshi Watabe

    Annals of nuclear medicine　36　(5)　479-487　2022/02/23

    DOI： 10.1007/s12149-022-01727-7 　

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    OBJECTIVE: Transarterial Radioembolization (TARE) with 90Y-loaded glass microspheres is a locoregional treatment option for Hepatocellular Carcinoma (HCC). Post-treatment 90Y bremsstrahlung imaging using Single-Photon Emission Tomography (SPECT) is currently a gold-standard imaging modality for quantifying the delivered dose. However, the nature of bremsstrahlung photons causes difficulty for dose estimation using SPECT imaging. This work aimed to investigate the possibility of using glass microspheres loaded with 90Y and Nanoparticles (NPs) to improve the quantification of delivered doses. METHODS: The Monte Carlo codes were used to simulate the post-TARE 90Y planar imaging. Planar images from bremsstrahlung photons and characteristic X-rays are acquired when 0, 1.2 mol/L, 2.4 mol/L, and 4.8 mol/L of Gold (Au), Hafnium (Hf), and Gadolinium (Gd) NPs are incorporated into the glass microspheres. We evaluated the quality of acquired images by calculating sensitivity and Signal-to-Background Ratio (SBR). Therapeutic effects of NPs were evaluated by calculation of Dose Enhancement Ratio (DER) in tumoral and non-tumoral liver tissues. RESULTS: The in silico results showed that the sensitivity values of bremsstrahlung and characteristic X-ray planar images increased significantly as the NPs concentration increased in the glass microspheres. The SBR values decreased as the NPs concentration increased for the bremsstrahlung planar images. In contrast, the SBR values increased for the characteristic X-ray planar images when Hf and Gd were incorporated into the glass microspheres. The DER values decreased in the tumoral and non-tumoral liver tissues as the NPs concentration increased. The maximum dose reduction was observed at the NPs concentration of 4.8 mol/L (≈ 7%). CONCLUSIONS: The incorporation of Au, Hf, and Gd NPs into the glass microspheres improved the quality and quantity of post-TARE planar images. Also, treatment efficiency was decreased significantly at NPs concentration > 4.8 mol/L.

  54. New standards for phantom image quality and SUV harmonization range for multicenter oncology PET studies.

    Go Akamatsu, Naoki Shimada, Keiichi Matsumoto, Hiromitsu Daisaki, Kazufumi Suzuki, Hiroshi Watabe, Keiichi Oda, Michio Senda, Takashi Terauchi, Ukihide Tateishi

    Annals of nuclear medicine　36　(2)　144-161　2022/02

    DOI： 10.1007/s12149-021-01709-1 　

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    Not only visual interpretation for lesion detection, staging, and characterization, but also quantitative treatment response assessment are key roles for 18F-FDG PET in oncology. In multicenter oncology PET studies, image quality standardization and SUV harmonization are essential to obtain reliable study outcomes. Standards for image quality and SUV harmonization range should be regularly updated according to progress in scanner performance. Accordingly, the first aim of this study was to propose new image quality reference levels to ensure small lesion detectability. The second aim was to propose a new SUV harmonization range and an image noise criterion to minimize the inter-scanner and intra-scanner SUV variabilities. We collected a total of 37 patterns of images from 23 recent PET/CT scanner models using the NEMA NU2 image quality phantom. PET images with various acquisition durations of 30-300 s and 1800 s were analyzed visually and quantitatively to derive visual detectability scores of the 10-mm-diameter hot sphere, noise-equivalent count (NECphantom), 10-mm sphere contrast (QH,10 mm), background variability (N10 mm), contrast-to-noise ratio (QH,10 mm/N10 mm), image noise level (CVBG), and SUVmax and SUVpeak for hot spheres (10-37 mm diameters). We calculated a reference level for each image quality metric, so that the 10-mm sphere can be visually detected. The SUV harmonization range and the image noise criterion were proposed with consideration of overshoot due to point-spread function (PSF) reconstruction. We proposed image quality reference levels as follows: QH,10 mm/N10 mm ≥ 2.5 and CVBG ≤ 14.1%. The 10th-90th percentiles in the SUV distributions were defined as the new SUV harmonization range. CVBG ≤ 10% was proposed as the image noise criterion, because the intra-scanner SUV variability significantly depended on CVBG. We proposed new image quality reference levels to ensure small lesion detectability. A new SUV harmonization range (in which PSF reconstruction is applicable) and the image noise criterion were also proposed for minimizing the SUV variabilities. Our proposed new standards will facilitate image quality standardization and SUV harmonization of multicenter oncology PET studies. The reliability of multicenter oncology PET studies will be improved by satisfying the new standards.

  55. A review on AI in PET imaging.

    Keisuke Matsubara, Masanobu Ibaraki, Mitsutaka Nemoto, Hiroshi Watabe, Yuichi Kimura

    Annals of nuclear medicine　36　(2)　133-143　2022/02

    DOI： 10.1007/s12149-021-01710-8 　

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    Artificial intelligence (AI) has been applied to various medical imaging tasks, such as computer-aided diagnosis. Specifically, deep learning techniques such as convolutional neural network (CNN) and generative adversarial network (GAN) have been extensively used for medical image generation. Image generation with deep learning has been investigated in studies using positron emission tomography (PET). This article reviews studies that applied deep learning techniques for image generation on PET. We categorized the studies for PET image generation with deep learning into three themes as follows: (1) recovering full PET data from noisy data by denoising with deep learning, (2) PET image reconstruction and attenuation correction with deep learning and (3) PET image translation and synthesis with deep learning. We introduce recent studies based on these three categories. Finally, we mention the limitations of applying deep learning techniques to PET image generation and future prospects for PET image generation.

  56. An Analysis Scheme for 3D Visualization of Positron Emitting Radioisotopes Using Positron Emission Mammography System

    Md. Rafiqul Islam, Mehrdad Shahmohammadi Beni, Shigeki Ito, Shinichi Gotoh, Taiga Yamaya, Hiroshi Watabe

    Applied Sciences　12　(2)　823-823　2022/01/14

    Publisher: {MDPI} {AG}

    DOI： 10.3390/app12020823 　

  57. RadStat: An open-source statistical analysis tool for counts obtained by a GM counter. International-journal

    Mehrdad Shahmohammadi Beni, Hiroshi Watabe, Wing Sum Kwan, M Rafiqul Islam, Kwan Ngok Yu

    PloS one　17　(5)　e0267610　2022

    DOI： 10.1371/journal.pone.0267610 　

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    The interaction of ionizing radiation with matter is a stochastic process and statistical analysis of such a process would be a crucial step in understanding radioactivity. Geiger-Müller (GM) counter is a widely used radiation detector used in nuclear radiation surveying, which produces counts upon exposure to a radioactive source. There are a variety of multi-purpose software that can be used to perform statistical analysis of measured counts from a GM counter. However, statistical analysis is a lengthy, error prone and time-consuming process, which gets more tedious when the number of measurements increases. In the present work, we have developed an open-source and easy-to-use graphical user interface (GUI) computer program named RadStat for statistical analysis of counts measured by a GM counter. RadStat has its own scripting syntaxes and bundled with gnuplot for quick visualization of output results. We believe the present open-source GUI program would be a useful tool for research and teaching of nuclear radiation physics.

  58. Proton range monitoring using 13N peak for proton therapy applications. International-journal

    M Rafiqul Islam, Mehrdad Shahmohammadi Beni, Chor-Yi Ng, Masayasu Miyake, Mahabubur Rahman, Shigeki Ito, Shinichi Gotoh, Taiga Yamaya, Hiroshi Watabe

    PloS one　17　(2)　e0263521　2022

    DOI： 10.1371/journal.pone.0263521 　

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    The Monte Carlo method is employed in this study to simulate the proton irradiation of a water-gel phantom. Positron-emitting radionuclides such as 11C, 15O, and 13N are scored using the Particle and Heavy Ion Transport Code System Monte Carlo code package. Previously, it was reported that as a result of 16O(p,2p2n)13N nuclear reaction, whose threshold energy is relatively low (5.660 MeV), a 13N peak is formed near the actual Bragg peak. Considering the generated 13N peak, we obtain offset distance values between the 13N peak and the actual Bragg peak for various incident proton energies ranging from 45 to 250 MeV, with an energy interval of 5 MeV. The offset distances fluctuate between 1.0 and 2.0 mm. For example, the offset distances between the 13N peak and the Bragg peak are 2.0, 2.0, and 1.0 mm for incident proton energies of 80, 160, and 240 MeV, respectively. These slight fluctuations for different incident proton energies are due to the relatively stable energy-dependent cross-section data for the 16O(p,2p2n)13N nuclear reaction. Hence, we develop an open-source computer program that performs linear and non-linear interpolations of offset distance data against the incident proton energy, which further reduces the energy interval from 5 to 0.1 MeV. In addition, we perform spectral analysis to reconstruct the 13N Bragg peak, and the results are consistent with those predicted from Monte Carlo computations. Hence, the results are used to generate three-dimensional scatter plots of the 13N radionuclide distribution in the modeled phantom. The obtained results and the developed methodologies will facilitate future investigations into proton range monitoring for therapeutic applications.

  59. Performance improvement of Compton imaging of astatine-211 by optimising coincidence time windows

    Y. Nagao, M. Yamaguchi, S. Watanabe, N.S. Ishioka, N. Kawachi, H. Watabe

    Journal of Instrumentation　16　(12)　2021/12/01

    Publisher: {IOP} Publishing

    DOI： 10.1088/1748-0221/16/12/c12031 　

    ISSN： 1748-0221

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    <jats:title>Abstract</jats:title> <jats:p>Astatine-211 is one of the promising radioisotopes for targeted alpha therapy. Optimising treatment strategies as well as determining the suitability of a given agent for a particular patient requires to image the time-dependent distribution of the targeted radiotherapeutic agent both in tumours and in normal tissues. Since the biodistribution of astatine is different from that of iodine, imaging astatine-211 directly is essential. In the previous study of astatine-211 Compton imaging, random coincidence events due to polonium K-shell X-rays were dominant and seemed to cause saturation of counts. Thus optimisation of the coincidence time windows is important to reduce random coincidence events. In this study, we have optimised the coincidence time windows of a Compton camera and improved the sensitivity, noise and spatial resolution of astatine-211 imaging.</jats:p>

  60. New evidence of arsenic translocation and accumulation in Pteris vittata from real-time imaging using positron-emitting 74As tracer International-journal

    Yi Huang-Takeshi Kohda, Zhaojie Qian, Mei-Fang Chien, Keisuke Miyauchi, Ginro Endo, Nobuo Suzui, Yong-Gen Yin, Naoki Kawachi, Hayato Ikeda, Hiroshi Watabe, Hidetoshi Kikunaga, Nobuyuki Kitajima, Chihiro Inoue

    Scientific Reports　11　(1)　12149-12149　2021/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-021-91374-1 　

    eISSN： 2045-2322

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    <title>Abstract</title><italic>Pteris vittata</italic> is an arsenic (As) hyperaccumulator plant that accumulates a large amount of As into fronds and rhizomes (around 16,000 mg/kg in both after 16 weeks hydroponic cultivation with 30 mg/L arsenate). However, the sequence of long-distance transport of As in this hyperaccumulator plant is unclear. In this study, we used a positron-emitting tracer imaging system (PETIS) for the first time to obtain noninvasive serial images of As behavior in living plants with positron-emitting 74As-labeled tracer. We found that As kept accumulating in rhizomes as in fronds of <italic>P. vittata</italic>, whereas As was retained in roots of a non-accumulator plant <italic>Arabidopsis thaliana</italic>. Autoradiograph results of As distribution in <italic>P</italic>. <italic>vittata</italic> showed that with low As exposure, As was predominantly accumulated in young fronds and the midrib and rachis of mature fronds. Under high As exposure, As accumulation shifted from young fronds to mature fronds, especially in the margin of pinna, which resulted in necrotic symptoms, turning the marginal color to gray and then brown. Our results indicated that the function of rhizomes in <italic>P. vittata</italic> was As accumulation and the regulation of As translocation to the mature fronds to protect the young fronds under high As exposure.

  61. Radioprotective Role of Vitamins C and E against the Gamma Ray-Induced Damage to the Chemical Structure of Bovine Serum Albumin. International-journal

    Hajar Zarei, Mostean Bahreinipour, Yahya Sefidbakht, Shokouh Rezaei, Rouhollah Gheisari, Susan Kabudanian Ardestani, Vuk Uskoković, Hiroshi Watabe

    Antioxidants (Basel, Switzerland)　10　(12)　2021/11/24

    DOI： 10.3390/antiox10121875 　

    eISSN： 2076-3921

  62. Theoretical study of e<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" id="d1e2146" altimg="si12.svg"><mml:msup><mml:mrow /><mml:mrow><mml:mo>±</mml:mo></mml:mrow></mml:msup></mml:math> scattering by the Au atom

    M. Mousumi Khatun, M.M. Haque, M. Atiqur R. Patoary, M. Shorifuddoza, Mahmudul H. Kh, ker, A.K. Fazlul Haque, Hiroshi Watabe, M. Alfaz Uddin

    Results in Physics　29　104742-104742　2021/10

    Publisher: Elsevier {BV}

    DOI： 10.1016/j.rinp.2021.104742 　

    ISSN： 2211-3797

  63. 安全かつ有効なGa-68/O-15ガスPET検査のための合理的な放射線管理基準の策定

    志賀 哲, 久下 裕司, 上原 知也, 久冨 信之, 志水 陽一, 下瀬川 恵久, 渡部 浩司

    核医学　58　(Suppl.)　S188-S188　2021/10

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  64. Relativistic Study on the Scattering of e± from Atoms and Ions of the Rn Isonuclear Series

    Mahmudul H. Khandker, A. K. Fazlul Haque, M. M. Haque, M. Masum Billah, Hiroshi Watabe, M. Alfaz Uddin

    Atoms　2021/08/27

    DOI： 10.3390/atoms9030059 　

  65. SecureVision: An Open-Source User-Customizable Image Encryption Program

    Mehrdad Shahmohammadi Beni, Hiroshi Watabe, Kwan Ngok Yu

    Applied Sciences　2021/08/27

    DOI： 10.3390/app11177915 　

  66. CompVision: An open-source five-compartmental software for biokinetic simulations

    Mehrdad Shahmohammadi Beni, Hiroshi Watabe, Kwan Ngok Yu

    Open Physics　19　(1)　454-459　2021/08/06

    Publisher: Walter de Gruyter {GmbH}

    DOI： 10.1515/phys-2021-0055 　

    ISSN： 2391-5471

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    <jats:title>Abstract</jats:title> <jats:p>Simulations and numerical analysis of physical problems are important steps toward understanding underlying mechanisms of the processes. Important examples would be medical physics and medical imaging. Compartmental modeling has been found useful for estimating the transport and temporal variations of drugs/contaminants (commonly used in medical physics and medical imaging) in different organs, given that different organs would be modeled as compartments. Recycling among these modeled compartments (i.e., organs) was allowed through defining sets of constant transfer rates. In order to mathematically define these systems, one needs to use sets of differential equations (depending on the number of compartments) which would in fact be time-consuming and prone to mathematical error. Considering these issues, there is a need for a versatile computer program that is accurate, robust, and user-friendly to perform the required computations automatically. In the present work, we developed and benchmarked an open-source computer program entitled CompVision that was able to simulate five-compartmental systems. The present software had an easy-to-use graphical user interface (GUI) for the users. The executable program and the source codes were made available publicly under GPLv3 license, which would allow everyone to use, modify, and distribute without any restriction. The present program would be useful in a variety of research fields and applications.</jats:p>

  67. Survey Report of RI Production and Application in 2019 Peer-reviewed

    RADIOISOTOPES　70　(4)　251-260　2021/07/15

    Publisher: Japan Radioisotope Association

    DOI： 10.3769/radioisotopes.70.251 　

    ISSN： 0033-8303

    eISSN： 1884-4111

  68. Theoretical investigations of e ± –CO scattering

    M Masum Billah, Mahmudul H Khandker, M Shorifuddoza, M A Sayed, Hiroshi Watabe, A K F Haque, M Alfaz Uddin

    Journal of Physics B: Atomic, Molecular and Optical Physics　54　(9)　095203-095203　2021/05/05

    Publisher: {IOP} Publishing

    DOI： 10.1088/1361-6455/abf6b4 　

    ISSN： 0953-4075

    eISSN： 1361-6455

  69. Greater reductions in blood flow after anti-angiogenic treatment in non-small cell lung cancer patients are associated with shorter progression-free survival. International-journal

    Daisuke Katayama, Masahiro Yanagawa, Keiko Matsunaga, Hiroshi Watabe, Tadashi Watabe, Hiroki Kato, Takashi Kijima, Yoshito Takeda, Atsushi Kumanogoh, Eku Shimosegawa, Jun Hatazawa, Noriyuki Tomiyama

    Scientific reports　11　(1)　6805-6805　2021/03/24

    DOI： 10.1038/s41598-021-86405-w 　

    ISSN： 2045-2322

  70. Theoretical studies on the elastic scattering of E± off the ions of xenon isonuclear series

    Mahmudul H. Khandker, M. Masum Billah, Hiroshi Watabe, A. K.F. Haque, M. Alfaz Uddin

    Physica Scripta　96　(2)　025402-025402　2021/02

    Publisher: {IOP} Publishing

    DOI： 10.1088/1402-4896/abd2e0 　

    ISSN： 0031-8949

    eISSN： 1402-4896

  71. ヒ素高蓄積植物モエジマシダ体内におけるヒ素の輸送過程のイメージング

    黄田 毅, 銭 照杰, 簡 梅芳, 井上 千弘, 宮内 啓介, 遠藤 銀郎, 池田 隼人, 菊永 英寿, 渡部 浩司, 鈴井 伸郎, 尹 永根, 河地 有木, 北島 信行

    アイソトープ・放射線研究発表会　1　32　2021

    Publisher: 公益社団法人 日本アイソトープ協会

    DOI： 10.50955/happyokai.1.0_32 　

    eISSN： 2436-4487

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    モエジマシダ (Pteris vittata) はヒ素(As)の高蓄積植物であり、乾燥重量当たり最大で20,000 mg/kg Asを蓄積することが知られており、ヒ素で汚染された土壌と水の植物浄化処理(phytoremediation)への応用に期待されている。これまでにモエジマシダにおけるAsの輸送過程は明らかにされていない。そこで本研究ではPETISを利用し74Asを用いて、モエジマシダが生きたままの状態で Asの輸送過程を観測した結果、根から吸収されたAsが根茎部に一度蓄積された後に地上部に輸送されることが明らかになった。

  72. 放射性Naを用いた植物輸送体の体内動態

    内山 剛志, 竹林 昂亮, 加藤 恵, 鈴井 伸郎, 尹 永根, 河地 有木, 藤巻 秀, 渡部 浩司, 池田 隼人, 菊永 英寿, 須田 利美, 遠山 翔, 三輪 美沙子, 松山 成男, 山上 睦, 石丸 泰寛, 魚住 信之

    アイソトープ・放射線研究発表会　1　89　2021

    Publisher: 公益社団法人 日本アイソトープ協会

    DOI： 10.50955/happyokai.1.0_89 　

    eISSN： 2436-4487

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    植物はナトリウム（Na）に曝されると生育が阻害されるため，Na+輸送体HKT1を介してNa+を輸送することで耐塩性に寄与する．これまで根の木部柔細胞におけるHKT1の耐塩性への寄与は明らかにされているが，地上部を含めた植物全体におけるHKT1の生理的役割は解明されていない。本研究では、22Naを用いてhkt1変異株とHKT1導入株におけるNa吸収および体内循環を検討した。さらに、植物におけるNaの蓄積組織の同定を行った。

  73. 健常者を対象としたPET診断薬18F-SMBT-1の全身臓器における生理的集積の観察

    石岡 有生, 四月朔日 聖一, 平岡 宏太良, 石川 洋一, 船木 善仁, 原田 龍一, 岡村 信行, 荒井 啓行, 古本 祥三, 谷内 一彦, 渡部 浩司, 田代 学

    日本臨床薬理学会学術総会抄録集　42　3-P-T-4　2021

    Publisher: 一般社団法人 日本臨床薬理学会

    DOI： 10.50993/jsptsuppl.42.0_3-p-t-4 　

    eISSN： 2436-5580

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    【目的】モノアミン酸化酵素B(MAO-B)は様々な臓器に分布して多様な機能を果たしているが、ヒトの全身分布の詳細はまだ十分に明らかにされていない。また最近では、アルツハイマー病患者の脳における神経炎症の一所見として増大する反応性アストロサイトにもMAO-Bが高発現することが知られている。我々は、MAO-Bに特異的に結合する新規PET診断薬剤18F-SMBT-1を開発し、ヒトにおいて脳を含む全身臓器のMAO-B分布に関する基礎データを構築するために初期臨床試験を開始した。【方法】健常成人男性4名(20～50歳代)を対象として、18F-SMBT-1のトレーサーを約185 MBq投与して、適宜休憩をはさみながら約5時間の全身PET測定を断続的に行った。PET画像をMRI画像に重ね合わせて各臓器への集積値を計測し、その時間的変化のパターンを調べた。 【結果・考察】PET薬剤18F-SMBT-1は、薬剤投与初期（最初の5分間）にすみやかに脳、心臓、胃、腎臓、消化管等に分布し、投与後から30分までは比較的高い取り込みを示しつつ、徐々に減少した。その後、肝臓および胆嚢に強い集積が観察され、薬剤投与後期には胆嚢、小腸～大腸、膀胱等に強い集積を示した。胆嚢の集積ピーク値は膀胱の10倍程度となった。また、全身の主要臓器における薬剤集積の変化に被験者間で大きな差異は認められなかった。小腸～大腸の集積所見については、胆汁排泄により薬剤が総肝管を経由し腸管に移動することが結果に影響している可能性が考えられ、生理的集積と排泄に伴う消化管集積が混在していると推測された。【結論】18F-SMBT-1は胆汁排泄の割合が高い薬剤であることがわかった。また、全身臓器のMAO-Bマッピングの目的に十分利用可能な薬剤であるとともに、脳マッピングのために十分な量の脳内分布があることがわかった。

  74. トータルバリエーションを用いた画像再構成法による骨SPECT撮像時間短縮の検討

    渡部 浩司, 銭谷 勉

    令和2年度第6回情報処理学会東北支部研究会資料　2020-6　2021

  75. MCHP (Monte Carlo + Human Phantom): Platform to facilitate teaching nuclear radiation physics. International-journal

    Mehrdad Shahmohammadi Beni, Hiroshi Watabe, Dragana Krstic, Dragoslav Nikezic, Kwan Ngok Yu

    PloS one　16　(9)　e0257638　2021

    DOI： 10.1371/journal.pone.0257638 　

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    Some concepts in nuclear radiation physics are abstract and intellectually demanding. In the present paper, an "MCHP platform" (MCHP was an acronym for Monte Carlo simulations + Human Phantoms) was proposed to provide assistance to the students through visualization. The platform involved Monte Carlo simulations of interactions between ionizing radiations and the Oak Ridge National Laboratory (ORNL) adult male human phantom. As an example to demonstrate the benefits of the proposed MCHP platform, the present paper investigated the variation of the absorbed photon dose per photon from a 137Cs source in three selected organs, namely, brain, spine and thyroid of an adult male for concrete and lead shields with varying thicknesses. The results were interesting but not readily comprehensible without direct visualization. Graphical visualization snapshots as well as video clips of real time interactions between the photons and the human phantom were presented for the involved cases, and the results were explained with the help of such snapshots and video clips. It is envisaged that, if the platform is found useful and effective by the readers, the readers can also propose examples to be gradually added onto this platform in future, with the ultimate goal of enhancing students' understanding and learning the concepts in an undergraduate nuclear radiation physics course or a related course.

  76. Radioprotective effect of nanoceria and magnetic flower-like iron oxide microparticles on gamma radiation-induced damage in BSA protein: Running Title: Radioprotective Effect of Nanostructures on BSA

    Bahreinipour, M., Zarei, H., Dashtestani, F., Rashidiani, J., Esk, ari, K., Zar, i, S.A.M., Ardestani, S.K., Watabe, H.

    AIMS Biophysics　8　(2)　124-142　2021

    Publisher: American Institute of Mathematical Sciences (AIMS)

    DOI： 10.3934/biophy.2021010 　

    ISSN： 2377-9098

  77. Error propagation analysis of seven partial volume correction algorithms for [18F]THK-5351 brain PET imaging International-journal

    Senri Oyama, Ayumu Hosoi, Masanobu Ibaraki, Colm J. McGinnity, Keisuke Matsubara, Shoichi Watanuki, Hiroshi Watabe, Manabu Tashiro, Miho Shidahara

    EJNMMI Physics　7　(1)　57-57　2020/12/01

    DOI： 10.1186/s40658-020-00324-9 　

    ISSN： 2197-7364

    eISSN： 2197-7364

  78. Non-invasive imaging of radiocesium dynamics in a living animal using a positron-emitting 127Cs tracer International-journal

    Nobuo Suzui, Takuya Shibata, Yong Gen Yin, Yoshihito Funaki, Keisuke Kurita, Hiroyuki Hoshina, Mitsutaka Yamaguchi, Shu Fujimaki, Noriaki Seko, Hiroshi Watabe, Naoki Kawachi

    Scientific Reports　10　(1)　16155-16155　2020/12/01

    DOI： 10.1038/s41598-020-73351-2 　

    ISSN： 2045-2322

    eISSN： 2045-2322

  79. 金属ジルコニウムおよび酸化ジルコニウムをターゲットとしたキャリアフリーMo-99製造法の開発

    池田 隼人, 菊永 英寿, 渡部 浩司

    核医学　57　(Suppl.)　S158-S158　2020/10

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  80. Iodine-131 labeled genistein as a potential radiotracer for breast cancer International-journal

    Danni Ramdhani, Eva Maria Widyasari, Maula Eka Sriyani, Quinzheilla Putri Arnanda, Hiroshi Watabe

    Heliyon　6　(9)　e04780　2020/09

    DOI： 10.1016/j.heliyon.2020.e04780 　

    ISSN： 2405-8440

  81. Theoretical investigation of the elastic scattering of by the ions of nitrogen isonuclear series

    M. Shorifuddoza, Mahmudul H. Khandker, A. K.F. Haque, Hiroshi Watabe, M. Alfaz Uddin

    Physica Scripta　95　(8)　2020/08

    DOI： 10.1088/1402-4896/ab9cfb 　

    ISSN： 0031-8949

    eISSN： 1402-4896

  82. 大学間の放射線業務従事者一元管理システムの構築

    渡部 浩司, 佐藤 和則, 三宅 正泰, 泉川 卓司, 矢永 誠人, 吉村 崇, 山西 弘城, 宮本 昌明, 寺東 宏明, 北 実

    日本保健物理学会研究発表会講演要旨集　53回　7-7　2020/06

    Publisher: (一社)日本保健物理学会

  83. 大学間の放射線業務従事者一元管理システムの構築

    渡部 浩司, 佐藤 和則, 三宅 正泰, 泉川 卓司, 矢永 誠人, 吉村 崇, 山西 弘城, 宮本 昌明, 寺東 宏明, 北 実

    日本保健物理学会研究発表会講演要旨集　53回　7-7　2020/06

    Publisher: (一社)日本保健物理学会

  84. Validation of the Image Registration Technique from Functional Near Infrared Spectroscopy (fNIRS) Signal and Positron Emission Tomography (PET) Image

    Fairuz Mohd Nair, Hiroshi Watabe

    Int J Manag Human　4　(9)　63-69　2020/05/10

    Publisher: Blue Eyes Intelligence Engineering and Sciences Engineering and Sciences Publication - BEIESP

    DOI： 10.35940/ijmh.i0877.054920 　

    eISSN： 2394-0913

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    : Functional near infrared spectroscopy (fNIRS) is an imaging system that can measure hemodynamic changes of the brain. However, the system incapability to measure beyond the brain cortex region make it usage less appealing for in-depth brain studies. To overcome this, many researchers combine fNIRS with other imaging modalities to gain better understanding of the brain activities. In this paper, we described the theory of the registering fNIRS signals and positron emission tomography (PET) image method and performed experiments to validate it. The registration method was validated using specially designed phantom for fNIRS and PET. Polaris system was used to track the position of the phantom which is based on the Polaris markers during fNIRS and PET procedures. The Polaris markers share the same coordinate, thus the fNIRS and PET were calibrated to each other through these markers. To register the fNIRS signal on the PET image, the phantom position in fNIRS coordinate is translated to PET coordinate which allow the probe and the markers being coordinated in PET. Polaris markers were used as the references marker to determine the transformation matrices. The result shows that the fNIRS channel can be viewed on the PET image of the phantom. The transformation error from Polaris to PET is less than 1.00 mm and the precision test is less than 0.1mm while the accuracy is less than 2.8 mm. This result suggests that our theory on the registration method could be used for multimodal image registration between fNIRS and other modalities.

  85. Multimodal Functional Near-Infrared Spectroscopy in Monitoring Cerebral Haemodynamic: A Review Article

    Fairuz Mohd Nasir, Hiroshi Watabe

    Asian Journal of Medicine and Biomedicine　4　(1)　47-52　2020/04/30

    Publisher: Universiti Sultan Zainal Abidin

    DOI： 10.37231/ajmb.2020.4.1.330 　

    eISSN： 2600-8173

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    Functional near-infrared spectroscopy (fNIRS) is an optical imaging tool to study brain activities. Moreover, many researchers combined fNIRS with other modalities to gain a better understanding of the brain. This paper provides an overview of the combination of fNIRS with other imaging modalities in the detection and measurement of the cerebral hemodynamic. Cerebral haemodynamic such as the cerebral blood flow (CBF), cerebral blood volume (CBV) and cerebral blood oxygenation (CBO) are the important parameters in many neuroimaging studies. Cerebral hemodynamic had been studied by various medical imaging modalities.  Initially, Xenon enhanced Computed Tomography (Xenon CT), Computed Tomography (CT) perfusion; Single Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET) are used to measure the cerebral hemodynamic. Recently, fNIRS is used to optically observe the changes in cerebral haemodynamic during brain activities and the combination of fNIRS with other modalities also become an interest to study the relations within brain activities and the cerebral hemodynamic. Therefore, this paper provides an overview of existing multimodal fNIRS in detection of cerebral haemodynamic changes and provides an important insight on how multimodal fNIRS aid in advancing modern investigations of human brain function.&#x0D;  &#x0D;  &#x0D;  &#x0D; Keywords: multimodal imaging, fNIRS-fMRI, fNIRS-PET, fNIRS-EEG

  86. Measurement and Comparison of Output Factors Using Two Detectors for NOVAC7 IntraOperative Radiotherapy Accelerator Peer-reviewed

    International Journal of Medical Physics, Clinical Engineering and Radiation Oncology　9　(2)　52-61　2020/04

  87. (R)- and (S)-ketamine induce differential fMRI responses in conscious rats International-journal Peer-reviewed

    Yukiko Masaki, Yuto Kashiwagi, Hiroshi Watabe, Kohji Abe

    Synapse　73　(12)　e22126　2019/12/01

    DOI： 10.1002/syn.22126 　

    ISSN： 0887-4476

    eISSN： 1098-2396

  88. Error evaluation of the D-shuttle dosimeter technique in positron emission tomography study Peer-reviewed

    Md Shahidul Islam, Shoichi Watanuki, Manabu Tashiro, Hiroshi Watabe

    Radiological Physics and Technology　12　(4)　363-373　2019/12/01

    Publisher: Springer Science and Business Media {LLC}

    DOI： 10.1007/s12194-019-00530-w 　

    ISSN： 1865-0333

    eISSN： 1865-0341

  89. 抗ヒスタミン薬が認知課題遂行中の脳エネルギー消費に与える影響 FDG PET研究

    田代 学, 鈴木 頌也, Chen Edmond, 菊地 飛鳥, 稲見 暁惠, 三宅 正泰, Nasir Fairuz Mohd, 平岡 宏太良, 四月朔日 聖一, 谷内 一彦, 渡部 浩司

    核医学　56　(Suppl.)　S161-S161　2019/10

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  90. Effect of Total Variation Regularization in Bone SPECT Reconstruction from a Small Number of Projections

    Michikazu Kanazawa, Tenta Sasaya, Shota Hosokawa, Hiroshi Watabe, Tetsuya Yuasa, Yasuyuki Takahashi, Tsutomu Zeniya

    2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019　2019/10

    DOI： 10.1109/NSS/MIC42101.2019.9059901 　

  91. A novel Tungsten-based fiducial marker for multi-modal brain imaging International-journal Peer-reviewed

    Takayuki Ose, Joonas A. Autio, Masahiro Ohno, Kantaro Nishigori, Nobuyoshi Tanki, Ami Igesaka, Tomoko Mori, Hisashi Doi, Yasuhiro Wada, Iwao Nakajima, Hiroshi Watabe, Takuya Hayashi

    Journal of Neuroscience Methods　323　22-31　2019/07/15

    DOI： 10.1016/j.jneumeth.2019.04.014 　

    ISSN： 0165-0270

    eISSN： 1872-678X

  92. Mismatching effects of antihistamines on regional brain glucose metabolism and blood flow in human brain: A combined study with [F-18]FDG PET and NIRS Peer-reviewed

    Tashiro M, Suzuki N, Chen E, Kikuchi A, Inami A, Nasir F. B. M, Miyake M, Watanuki S, Yanai K, Watabe H

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　39　583-584　2019/07

    ISSN： 0271-678X

  93. A systematic performance evaluation of head motion correction techniques for 3 commercial PET scanners using a reproducible experimental acquisition protocol Peer-reviewed

    Takato Inomata, Shoichi Watanuki, Hayato Odagiri, Takeyuki Nambu, Nicolas A. Karakatsanis, Hiroshi Ito, Hiroshi Watabe, Manabu Tashiro, Miho Shidahara

    Annals of Nuclear Medicine　33　(7)　459-470　2019/07/01

    DOI： 10.1007/s12149-019-01353-w 　

    ISSN： 0914-7187

    eISSN： 1864-6433

  94. Biomathematical Modeling Approach to Predict Clinical SUVRs for Amyloid PET Imaging

    Shidahara M, Seki C, Nai YH, Okamura, Furumoto S, Yanai K, Watabe H, Tashiro M

    CYRIC Annual Report 2016-2017　147-151　2019/04

  95. Partial Volume Corrections for Tau and Amyloid PET Imaging with [18F]THK5351 and [11C]PiB

    Shidahara M, Thomas AB, Okamura N, Ibaraki M, Matsubara K, Oyama S, Ishikawa Y, Watanuki S, Iwata R, Furumoto S, Yanai K, Watabe H, Tashiro M

    CYRIC Annual Report 2016-2017　142-146　2019/04

  96. 管球X線を用いた蛍光CTのシミュレーションによる基礎検討

    越野 一博, 渡部 浩司, 銭谷 勉

    令和元年度第6回情報処理学会東北支部研究会（弘前大学）資料　2019-6　1-6　2019

  97. REGISTRATION OF POSITRON EMISSION TOMOGRAPHY (PET) IMAGE AND FUNCTIONAL NEAR INFRARED SPECTROSCOPY (NIRS) DATA Peer-reviewed

    Fairuz Binti Mohd Nasir, Asuka Kikuchi, Shoichi Watanuki, Masayasu Miyake, Manabu Tashiro, Hiroshi Watabe

    International Journal of Bioscience, Biochemistry and Bioinformatics　9　(1)　9-19　2019

    DOI： 10.17706/ijbbb.2019.9.1.9-19 　

  98. Renal statistical map for positron emission tomography with [O-15] water. International-journal Peer-reviewed

    Mahabubur Rahman, Hiroshi Watabe, Miho Shidahara, Shoichi Watanuki, Manabu Tashiro, Takefumi Mori, Sadayoshi Ito, Yusuke Ohsaki

    American journal of nuclear medicine and molecular imaging　9　(4)　193-202　2019

    ISSN： 2160-8407

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    Image statistics are frequently used for functional and molecular imaging research in which images from a patient group with a specific diagnosis are compared with images from a healthy control group who have been matched for demographic variables. The success of image statistics for brain imaging has encouraged us to develop a method for obtaining volumetrically normalized kidney to perform image statistics so that we can locally visualize the statistical significant difference comparing voxel by voxel between certain groups in terms kidney blood flow kinetic parameters. For the development of this evolutionary process, we first volumetrically normalized all subjects, which include healthy control (HC) and chronic renal failure (CRF) patients, 15O water PET image with respect to one HC subject's MRI image using affine transformation. Then 15O kinetic parametric images of normalized kidneys were obtained through the basis function method. Finally, the statistical map of these parametric images was produced using the threshold-free cluster enhancement based permutation method. Kinetic parameters of kidney namely, uptake rate constant (K1), clearance rate constant (k2) and blood volume (Va), were found to be notably lower in CRF than those of in HC and k2 parameter was found to be more stable compared to K1 and Va. The statistical map of these parametric images allowed us to visualize local significant differences statistically (P<0.05) between HC and CRF groups. Though PET and MRI techniques have enormous potentiality for functional and molecular imaging of kidney, these are, at best, in experimental level. It is speculated that statistical mapping of kidney could play a significant role in the successful implementation of functional and molecular kidney imaging. However, more research involving a larger sample size and improved normalization technique will be needed for the robustness of the process.

  99. Development of a cost-effective Compton camera using a positron emission tomography data acquisition system Peer-reviewed

    Yuto Nagao, Mitsutaka Yamaguchi, Naoki Kawachi, Hiroshi Watabe

    Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment　912　20-23　2018/12/21

    DOI： 10.1016/j.nima.2017.10.009 　

    ISSN： 0168-9002

  100. Using short half-life nucleus 107Cd to real-time imaging and analysis cadmium dynamics in Cd-hyperaccumulator Arabidopsis halleri ssp.gemmifera by PETIS system

    CYRIC Annual Report 2016-2017　2018/12

  101. Investigation of the quantitative accuracy of low-dose amyloid and tau PET imaging Peer-reviewed

    Ying Hwey Nai, Shoichi Watanuki, Manabu Tashiro, Nobuyuki Okamura, Hiroshi Watabe

    Radiological Physics and Technology　11　(4)　451-459　2018/12/01

    DOI： 10.1007/s12194-018-0485-y 　

    ISSN： 1865-0333

    eISSN： 1865-0341

  102. Establishment of a Novel Detection System for Measuring Primary Knock-on Atoms

    Pi En Tsai, Yosuke Iwamoto, Masayuki Hagiwara, Tatsuhiko Sato, Tatsuhiko Ogawa, Daiki Satoh, Shin Ichiro Abe, Masatoshi Itoh, Hiroshi Watabe

    2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017 - Conference Proceedings　2018/11/12

    DOI： 10.1109/NSSMIC.2017.8532975 　

  103. 頭部PET体動補正精度の装置間比較 統一実験プロトコルを用いた検討

    猪又 嵩斗, 志田原 美保, 四月朔日 聖一, 小田桐 逸人, 南部 武幸, 伊藤 浩, 田代 学, 渡部 浩司

    核医学技術　38　(予稿集)　403-403　2018/10

    Publisher: (NPO)日本核医学技術学会

    ISSN： 0289-100X

  104. Error propagation properties of 5 partial volume correction algorithms for [F-18]THK5351 PET imaging Peer-reviewed

    Oyama S, Shidahara M, Thomas B. A, Matsubara K, Ibaraki M, Watanuki S, Watabe H, Tashiro M

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　45　S300　2018/10

    ISSN： 1619-7070

  105. Internal radiation dose estimation using multiple D-shuttle dosimeters for positron emission tomography (PET): A validation study using NEMA body phantom International-journal Peer-reviewed

    Md Shahidul Islam, Shoichi Watanuki, Manabu Tashiro, Hiroshi Watabe

    Medical Physics　45　(10)　4693-4703　2018/10

    DOI： 10.1002/mp.13124 　

    ISSN： 0094-2405

  106. Astatine-211 imaging by a Compton camera for targeted radiotherapy International-journal Peer-reviewed

    Yuto Nagao, Mitsutaka Yamaguchi, Shigeki Watanabe, Noriko S. Ishioka, Naoki Kawachi, Hiroshi Watabe

    Applied Radiation and Isotopes　139　238-243　2018/09

    Publisher: Elsevier Ltd

    DOI： 10.1016/j.apradiso.2018.05.022 　

    ISSN： 0969-8043

    eISSN： 1872-9800

  107. Application of astatine-210: Evaluation of astatine distribution and effect of pre-injected iodide in whole body of normal rats International-journal Peer-reviewed

    Hayato Ikeda, Yoshihiko Hayashi, Naruto Takahashi, Tadashi Watabe, Yasukazu Kanai, Atsushi Shinohara, Hiroki Kato, Hiroshi Watabe, Eku Shimosegawa, Jun Hatazawa

    Applied Radiation and Isotopes　139　251-255　2018/09

    DOI： 10.1016/j.apradiso.2018.05.021 　

    ISSN： 0969-8043

    eISSN： 1872-9800

  108. Novel regenerative therapy combined with transphrenic peritoneoscopy-assisted omentopexy International-journal Peer-reviewed

    Satoshi Kainuma, Kiyokazu Nakajima, Shigeru Miyagawa, Satsuki Fukushima, Atsuhiro Saito, Akima Harada, Masashi Hirota, Yasuhiro Miyazaki, Noriyoshi Sawabata, Tadashi Watabe, Hiroshi Watabe, Koichi Toda, Jun Hatazawa, Meinoshin Okumura, Yoshiki Sawa

    Interactive Cardiovascular and Thoracic Surgery　26　(6)　993-1001　2018/06/01

    Publisher: Oxford University Press

    DOI： 10.1093/icvts/ivx430 　

    ISSN： 1569-9293

    eISSN： 1569-9285

  109. 18F-fluorodeoxyglucose specimen-positron emission mammography delineates tumour extension in breast-conserving surgery: Preliminary results

    Gou Watanabe, M. Itoh, X. Duan, H. Watabe, N. Mori, H. Tada, A. Suzuki, M. Miyashita, N. Ohuchi, T. Ishida

    European Radiology　28　(5)　1929-1937　2018/05/01

    DOI： 10.1007/s00330-017-5170-8 　

    ISSN： 0938-7994

    eISSN： 1432-1084

  110. Effects of levocetirizine and diphenhydramine on regional glucose metabolic changes and hemodynamic responses in the human prefrontal cortex during cognitive tasks International-journal Peer-reviewed

    Asuka Kikuchi, Fairuz Binti Mohammadi Nasir, Akie Inami, Attayeb Mohsen, Shoichi Watanuki, Masayasu Miyake, Kazuko Takeda, Daigo Koike, Takayasu Ito, Junpei Sasakawa, Rin Matsuda, Kotaro Hiraoka, Marcus Maurer, Kazuhiko Yanai, Hiroshi Watabe, Manabu Tashiro

    HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL　33　(2)　e2655　2018/03

    DOI： 10.1002/hup.2655 　

    ISSN： 0885-6222

    eISSN： 1099-1077

  111. Development of a circular shape Si-PM-based detector ring for breast-dedicated PET system Peer-reviewed

    Kouhei Nakanishi, Seiichi Yamamoto, Hiroshi Watabe, Shinji Abe, Naotoshi Fujita, Katsuhiko Kato

    Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment　880　118-124　2018/02/01

    Publisher: Elsevier B.V.

    DOI： 10.1016/j.nima.2017.10.052 　

    ISSN： 0168-9002

  112. コンパートメントモデルを理解しよう

    渡部浩司

    核医学技術　38　(1)　79‐81　2018/01/30

    ISSN： 0289-100X

  113. Simulation study of influence of scattered radiation in fluorescence CT using x-ray tube: A comparison with synchrotron radiation Peer-reviewed

    Tohoku-Section Joint Convention Record of Institutes of Electrical and Information Engineers, Japan　2018　(0)　206-206　2018

    Publisher: Organizing Committee of Tohoku-Section Joint Convention of Institutes of Electrical and Information Engineers, Japan

    DOI： 10.11528/tsjc.2018.0_206 　

  114. The legal procedure under Act on Prevention of Radiation Hazards due to Radioisotopes, etc. for realization of Supply Platform of Short-lived Radioisotopes for Fundamental Research

    SUZUKI Tomokazu, WATABE Hiroshi, KIKUNAGA Hidetoshi, HABA Hiromitsu, FUKUDA Mitsuhiro

    Japanese Journal of Radiation Safety Management　17　(2)　121-124　2018

    Publisher: Japanese Society of Radiation Safety Management

    DOI： 10.11269/jjrsm.17.121 　

    ISSN： 1347-1503

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    <p> Supply Platform of Short-lived Radioisotopes for Fundamental Research has been started since 2016. Purpose of this program is to provide non-commercial RIs from accelerator facilities to researchers of various scientific fields after approving the research projects. The suppliers are domestic 4 large accelerator facilities, which have permission to use radiation generating apparatus under "Act on Prevention of Radiation Hazards due to Radioisotopes, etc.". However, it is an open question whether these facilities can provide RIs without legal notification of dealing businesses. In this paper, we report the record of how to make to be realized this platform under legal permission of use.</p>

  115. Forecast of Future of Radiocesium Pollution on the Cherry Tree Bark in Northern Fukushima Prefecture after the Accident at TEPCO's Fukushima-Daiichi Nuclear Power Plant using Data of Current South Tohoku District of Japan and Around Chernobyle

    杉浦広幸, 酒井創, 渡部浩司

    日本放射線安全管理学会誌　17　(1)　9‐15(J‐STAGE)　2018

    DOI： 10.11269/jjrsm.17.9 　

    ISSN： 1347-1503

  116. Evaluation of the Feasibility of Screening Tau Radiotracers Using an Amyloid Biomathematical Screening Methodology. International-journal Peer-reviewed

    Ying-Hwey Nai, Hiroshi Watabe

    Comput. Math. Methods Medicine　2018　6287913-13　2018

    DOI： 10.1155/2018/6287913 　

    ISSN： 1748-670X

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    The purpose of this study is to evaluate the feasibility of extending a previously developed amyloid biomathematical screening methodology to support the screening of tau radiotracers during compound development. 22 tau-related PET radiotracers were investigated. For each radiotracer, in silico MLogP, Vx, and in vitro KD were input into the model to predict the in vivo K1, k2, and BPND under healthy control (HC), mild cognitive impaired (MCI), and Alzheimer's disease (AD) conditions. These kinetic parameters were used to simulate the time activity curves (TACs) in the target regions of HC, MCI, and AD and a reference region. Standardized uptake value ratios (SUVR) were determined from the integrated area under the TACs of the target region over the reference region within a default time window of 90-110 min. The predicted K1, k2, and BPND values were compared with the clinically observed values. The TACs and SUVR distributions were also simulated with population variations and noise. Finally, the clinical usefulness index (CUI) ranking was compared with clinical comparison results. The TACs and SUVR distributions differed for tau radiotracers with lower tau selectivity. The CUI values ranged from 0.0 to 16.2, with 6 out of 9 clinically applied tau radiotracers having CUI values higher than the recommend CUI value of 3.0. The differences between the clinically observed TACs and SUVR results showed that the evaluation of the clinical usefulness of tau radiotracer based on single target binding could not fully reflect in vivo tau binding. The screening methodology requires further study to improve the accuracy of screening tau radiotracers. However, the higher CUI rankings of clinically applied tau radiotracers with higher signal-to-noise ratio supported the use of the screening methodology in radiotracer development by allowing comparison of candidate radiotracers with clinically applied radiotracers based on SUVR, with respect to binding to a single target.

  117. Online molecular image repository and analysis system: A multicenter collaborative open-source infrastructure for molecular imaging research and application. International-journal Peer-reviewed

    Mahabubur Rahman, Hiroshi Watabe

    Comput. Biol. Medicine　96　233-240　2018

    Publisher: Elsevier Ltd

    DOI： 10.1016/j.compbiomed.2018.04.001 　

    ISSN： 0010-4825

    eISSN： 1879-0534

  118. レボセチリジンの鎮静作用に関する脳ブドウ糖代謝および脳血流の変化の観察

    田代 学, 菊地 飛鳥, 稲見 暁惠, 三宅 正泰, Mohsen Attayeb, Nasir Fairuz, 松田 林, 平岡 宏太良, 四月朔日 聖一, 渡部 浩司, 谷内 一彦

    臨床薬理　48　(Suppl.)　S280-S280　2017/11

    Publisher: (一社)日本臨床薬理学会

    ISSN： 0388-1601

    eISSN： 1882-8272

  119. Biomathematical screening of amyloid radiotracers with clinical usefulness index. International-journal Peer-reviewed

    Ying-Hwey Nai, Miho Shidahara, Chie Seki, Hiroshi Watabe

    Alzheimer's & dementia (New York, N. Y.)　3　(4)　542-552　2017/11

    Publisher: Elsevier Inc

    DOI： 10.1016/j.trci.2017.08.006 　

    ISSN： 2352-8737

  120. ラットPETを用いたヒト内部被曝線量の非侵襲的推定手法の検討

    志田原 美保, 猪又 嵩斗, 小山 千莉, 船木 善仁, 田代 学, 古本 祥三, 谷内 一彦, 権田 幸祐, 渡部 浩司

    核医学　54　(Suppl.)　S199-S199　2017/09

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  121. トレーサブル68Ge/68Ga点状線源を用いるPET装置の校正法

    小山 翔司, 長谷川 智之, 井上 優介, 菊池 敬, 宮武 比呂樹, 我妻 慧, 宮司 典明, 渡部 浩司, 志田原 美保, 四月朔日 聖一, 津田 啓介, 村松 禎久, 柳澤 かおり, 和田 康弘, 織田 圭一, 佐藤 泰

    核医学技術　37　(予稿集)　481-481　2017/09

    Publisher: (NPO)日本核医学技術学会

    ISSN： 0289-100X

  122. 137Cs transmission imaging and segmented attenuation corrections in a small animal PET scanner Peer-reviewed

    Ying-Hwey Nai, Takayuki Ose, Miho Shidahara, Hiroshi Watabe

    Radiological Physics and Technology　10　(3)　321-330　2017/09/01

    Publisher: Springer Tokyo

    DOI： 10.1007/s12194-017-0407-4 　

    ISSN： 1865-0341 1865-0333

  123. Association of Coronary Perivascular Adipose Tissue Inflammation and Drug-Eluting Stent-Induced Coronary Hyperconstricting Responses in Pigs: 18F-Fluorodeoxyglucose Positron Emission Tomography Imaging Study. International-journal Peer-reviewed

    Kazuma Ohyama, Yasuharu Matsumoto, Hirokazu Amamizu, Hironori Uzuka, Kensuke Nishimiya, Susumu Morosawa, Michinori Hirano, Hiroshi Watabe, Yoshihito Funaki, Satoshi Miyata, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa

    Arteriosclerosis, thrombosis, and vascular biology　37　(9)　1757-1764　2017/09

    DOI： 10.1161/ATVBAHA.117.309843 　

    ISSN： 1079-5642

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    OBJECTIVE: Although coronary perivascular adipose tissue (PVAT) may play important roles as a source of inflammation, the association of coronary PVAT inflammation and coronary hyperconstricting responses remains to be examined. We addressed this important issue in a porcine model of coronary hyperconstricting responses after drug-eluting stent implantation with 18F-fluorodeoxyglucose (18F-FDG) positron emission tomographic imaging. APPROACH AND RESULTS: An everolimus-eluting stent (EES) was randomly implanted in pigs into the left anterior descending or the left circumflex coronary artery while nonstented coronary artery was used as a control. After 1 month, coronary vasoconstricting responses to intracoronary serotonin (10 and 100 μg/kg) were examined by coronary angiography in vivo, followed by in vivo and ex vivo 18F-FDG positron emission tomographic/computed tomographic imaging. Coronary vasoconstricting responses to serotonin were significantly enhanced at the EES edges compared with the control site (P<0.01; n=40). Notably, in vivo and ex vivo 18F-FDG positron emission tomographic/computed tomographic imaging and autoradiography showed enhanced 18F-FDG uptake and its accumulation in PVAT at the EES edges compared with the control site, respectively (both P<0.05). Furthermore, histological and reverse transcription polymerase chain reaction analysis showed that inflammatory changes of coronary PVAT were significantly enhanced at the EES edges compared with the control site (all P<0.01). Importantly, Rho-kinase expressions (ROCK1/ROCK2) and Rho-kinase activity (phosphorylated myosin phosphatase target subunit-1) at the EES edges were significantly enhanced compared with the control site. CONCLUSIONS: These results indicate for the first time that inflammatory changes of coronary PVAT are associated with drug-eluting stent-induced coronary hyperconstricting responses in pigs in vivo and that 18F-FDG positron emission tomographic imaging is useful for assessment of coronary PVAT inflammation.

  124. Prediction of the Clinical SUV Ratio in Amyloid PET Imaging Using a Biomathematic Modeling Approach Toward the Efficient Development of a Radioligand Peer-reviewed

    Yuma Arakawa, YingHwey Nai, Miho Shidahara, Shozo Furumoto, Chie Seki, Nobuyuki Okamura, Manabu Tashiro, Yukitsuka Kudo, Kazuhiko Yanai, Kohsuke Gonda, Hiroshi Watabe

    JOURNAL OF NUCLEAR MEDICINE　58　(8)　1285-1292　2017/08

    DOI： 10.2967/jnumed.116.183566 　

    ISSN： 0161-5505

    eISSN： 1535-5667

  125. A comparison of five partial volume correction methods for Tau and Amyloid PET imaging with [F-18]THK5351 and [C-11]PIB Peer-reviewed

    Miho Shidahara, Benjamin A. Thomas, Nobuyuki Okamura, Masanobu Ibaraki, Keisuke Matsubara, Senri Oyama, Yoichi Ishikawa, Shoichi Watanuki, Ren Iwata, Shozo Furumoto, Manabu Tashiro, Kazuhiko Yanai, Kohsuke Gonda, Hiroshi Watabe

    ANNALS OF NUCLEAR MEDICINE　31　(7)　563-569　2017/08

    DOI： 10.1007/s12149-017-1185-0 　

    ISSN： 0914-7187

    eISSN： 1864-6433

  126. Validation of a Novel Calibration Method Using a Traceable 68Ge/68Ga Point-Like Source On Eleven Types of PET Scanners Peer-reviewed

    Koyama S, Hasegawa T, Miyatake H, Inoue Y, Kikuchi K, Wagatsuma K, Miyaji N, Watabe H, Shidahara M, Watanuki S, Tsuda K, Muramatsu Y, Yanagisawa K, Wada Y, Oda K, Sato Y, Yamada T

    MEDICAL PHYSICS　44　(6)　2017/06

    ISSN： 0094-2405

  127. 短寿命RI供給プラットフォーム Peer-reviewed

    渡部 浩司, 池田 隼人, 中野 貴志, 福田 光宏, 青井 考, 鈴木 智和, 高橋 成人, 酒見 泰寛, 羽場 宏光, 上垣外 修一, 伊藤 正俊, 菊永 英寿

    JSMI Report　10　(2)　173-173　2017/05

    Publisher: 日本分子イメージング学会

    ISSN： 1882-6490

  128. Three-dimensional dose distribution of proton beams derived from luminescence images of water Peer-reviewed

    S. Yamamoto, H. Watabe, T. Toshito, M. Komori

    JOURNAL OF INSTRUMENTATION　12　(5)　P05019　2017/05

    DOI： 10.1088/1748-0221/12/05/P05019 　

    ISSN： 1748-0221

  129. Development of a Cherenkov light imaging system for studying the dynamics of radiocesium in plants Peer-reviewed

    Keisuke Kurita, Nobuo Suzui, Yong-Gen Yin, Satomi Ishii, Hiroshi Watabe, Seiichi Yamamoto, Naoki Kawachi

    JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY　54　(6)　662-667　2017

    DOI： 10.1080/00223131.2017.1299051 　

    ISSN： 0022-3131

    eISSN： 1881-1248

  130. Development of ultrahigh resolution Si-PM-based PET system using 0.32 mm pixel scintillators Peer-reviewed

    Seiichi Yamamoto, Hiroshi Watabe, Tadashi Watabe, Hayato Ikeda, Yasukazu Kanai, Yoshimune Ogata, Katsuhiko Kato, Jun Hatazawa

    NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT　836　7-12　2016/11

    DOI： 10.1016/j.nima.2016.08.045 　

    ISSN： 0168-9002

    eISSN： 1872-9576

  131. Gd-EOB-DTPA-enhanced-MR imaging in the inflammation stage of nonalcoholic steatohepatitis (NASH) in mice Peer-reviewed

    Tomomi Yamada, Atsushi Obata, Yuto Kashiwagi, Takemi Rokugawa, Shuuichi Matsushima, Tadateru Hamada, Hiroshi Watabe, Kohji Abe

    MAGNETIC RESONANCE IMAGING　34　(6)　724-729　2016/07

    DOI： 10.1016/j.mri.2016.03.009 　

    ISSN： 0730-725X

    eISSN： 1873-5894

  132. Compartmental modeling in PET kinetics Peer-reviewed

    Hiroshi Watabe

    Basic Science of PET Imaging　323-352　2016/01/01

    Publisher: Springer International Publishing

    DOI： 10.1007/978-3-319-40070-9_14 　

  133. Performance evaluation of the small-animal PET scanner ClairvivoPET using NEMA NU 4-2008 Standards Peer-reviewed

    K. Sato, M. Shidahara, H. Watabe, S. Watanuki, Y. Ishikawa, Y. Arakawa, Y. H. Nai, S. Furumoto, M. Tashiro, T. Shoji, K. Yanai, K. Gonda

    PHYSICS IN MEDICINE AND BIOLOGY　61　(2)　696-711　2016/01

    DOI： 10.1088/0031-9155/61/2/696 　

    ISSN： 0031-9155

    eISSN： 1361-6560

  134. Imaging of radiocesium uptake dynamics in a plant body by using a newly developed high-resolution gamma camera Peer-reviewed

    Naoki Kawachi, Yong-Gen Yin, Nobuo Suzui, Satomi Ishii, Toshihiro Yoshihara, Hiroshi Watabe, Seiichi Yamamoto, Shu Fujimaki

    JOURNAL OF ENVIRONMENTAL RADIOACTIVITY　151　461-467　2016/01

    DOI： 10.1016/j.jenvrad.2015.04.009 　

    ISSN： 0265-931X

    eISSN： 1879-1700

  135. PET解析技術の開発

    渡部浩司, 志田原美保

    放射線　41　(4)　191-195　2016

    Publisher:

    ISSN： 0285-3604

  136. 抗VEGF療法後の甲状腺血流量変化の15O-H2O PETによる分析(Change in thyroid gland perfusion after anti-VEGF therapy studied by means of 15O-H2O PET)

    松永 恵子, 梁川 雅弘, 渡部 浩司, 藤埜 浩一, 渡部 直史, 礒橋 佳也子, 加藤 弘樹, 下瀬川 恵久, 畑澤 順

    核医学　52　(4)　399-399　2015/11

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  137. Quantitative kinetic analysis of PET amyloid imaging agents [C-11]BF227 and [F-18]FACT in human brain Peer-reviewed

    Miho Shidahara, Hiroshi Watabe, Manabu Tashiro, Nobuyuki Okamura, Shozo Furumoto, Shoichi Watanuki, Katsutoshi Furukawa, Yuma Arakawa, Yoshihito Funaki, Ren Iwata, Kohsuke Gonda, Yukitsuka Kudo, Hiroyuki Arai, Kiichi Ishiwata, Kazuhiko Yanai

    NUCLEAR MEDICINE AND BIOLOGY　42　(9)　734-744　2015/09

    DOI： 10.1016/j.nucmedbio.2015.05.001 　

    ISSN： 0969-8051

    eISSN： 1872-9614

  138. Development of dual-layer GSO depth-of-interaction block detector using angled optical fiber Peer-reviewed

    Satoshi Okumura, Seiichi Yamamoto, Hiroshi Watabe, Natsuki Kato, Huka Hamamura

    NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT　781　65-70　2015/05

    DOI： 10.1016/j.nima.2015.01.102 　

    ISSN： 0168-9002

    eISSN： 1872-9576

  139. Pharmacological MRI Response to a Selective Dopamine Transporter Inhibitor, GBR12909, in Awake and Anesthetized Rats Peer-reviewed

    Yuto Kashiwagi, Takemi Rokugawa, Tomomi Yamada, Atsushi Obata, Hiroshi Watabe, Yoshichika Yoshioka, Kohji Abe

    SYNAPSE　69　(4)　203-212　2015/04

    DOI： 10.1002/syn.21803 　

    ISSN： 0887-4476

    eISSN： 1098-2396

  140. Development of an Optical Fiber-Based MR Compatible Gamma Camera for SPECT/MRI Systems Peer-reviewed

    Seiichi Yamamoto, Tadashi Watabe, Yasukazu Kanai, Hiroshi Watabe, Jun Hatazawa

    IEEE TRANSACTIONS ON NUCLEAR SCIENCE　62　(1)　76-81　2015/02

    DOI： 10.1109/TNS.2014.2387432 　

    ISSN： 0018-9499

    eISSN： 1558-1578

  141. Cell-sheet therapy with omentopexy promotes arteriogenesis and improves coronary circulation physiology in failing heart. International-journal Peer-reviewed

    Satoshi Kainuma, Shigeru Miyagawa, Satsuki Fukushima, James Pearson, Yi Ching Chen, Atsuhiro Saito, Akima Harada, Motoko Shiozaki, Hiroko Iseoka, Tadashi Watabe, Hiroshi Watabe, Genki Horitsugi, Mana Ishibashi, Hayato Ikeda, Hirotsugu Tsuchimochi, Takashi Sonobe, Yutaka Fujii, Hisamichi Naito, Keiji Umetani, Tatsuya Shimizu, Teruo Okano, Eiji Kobayashi, Takashi Daimon, Takayoshi Ueno, Toru Kuratani, Koichi Toda, Nobuyuki Takakura, Jun Hatazawa, Mikiyasu Shirai, Yoshiki Sawa

    Molecular therapy : the journal of the American Society of Gene Therapy　23　(2)　374-86　2015/02

    DOI： 10.1038/mt.2014.225 　

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    Cell-sheet transplantation induces angiogenesis for chronic myocardial infarction (MI), though insufficient capillary maturation and paucity of arteriogenesis may limit its therapeutic effects. Omentum has been used clinically to promote revascularization and healing of ischemic tissues. We hypothesized that cell-sheet transplantation covered with an omentum-flap would effectively establish mature blood vessels and improve coronary microcirculation physiology, enhancing the therapeutic effects of cell-sheet therapy. Rats were divided into four groups after coronary ligation; skeletal myoblast cell-sheet plus omentum-flap (combined), cell-sheet only, omentum-flap only, and sham operation. At 4 weeks after the treatment, the combined group showed attenuated cardiac hypertrophy and fibrosis, and a greater amount of functionally (CD31(+)/lectin(+)) and structurally (CD31(+)/α-SMA(+)) mature blood vessels, along with myocardial upregulation of relevant genes. Synchrotron-based microangiography revealed that the combined procedure increased vascularization in resistance arterial vessels with better dilatory responses to endothelium-dependent agents. Serial (13)N-ammonia PET showed better global coronary flow reserve in the combined group, mainly attributed to improvement in the basal left ventricle. Consequently, the combined group had sustained improvements in cardiac function parameters and better functional capacity. Cell-sheet transplantation with an omentum-flap better promoted arteriogenesis and improved coronary microcirculation physiology in ischemic myocardium, leading to potent functional recovery in the failing heart.

  142. Ultrahigh-resolution Cerenkov-light imaging system for positron radionuclides: potential applications and limitations Peer-reviewed

    Seiichi Yamamoto, Tadashi Watabe, Hayato Ikeda, Yasukazu Kanai, Hiroshi Watabe, Yoshimune Ogata, Katsuhiko Kato, Jun Hatazawa

    ANNALS OF NUCLEAR MEDICINE　28　(10)　961-969　2014/12

    DOI： 10.1007/s12149-014-0892-z 　

    ISSN： 0914-7187

    eISSN： 1864-6433

  143. Distribution of Intravenously Administered Acetylcholinesterase Inhibitor and Acetylcholinesterase Activity in the Adrenal land: C-11-Donepezil PET Study in the Normal Rat Peer-reviewed

    Tadashi Watabe, Sadahiro Naka, Hayato Ikeda, Genki Horitsugi, Yasukazu Kanai, Kayako Isohashi, Mana Ishibashi, Hiroki Kato, Eku Shimosegawa, Hiroshi Watabe, Jun Hatazawa

    PLOS ONE　9　(9)　e107427-e107427　2014/09

    DOI： 10.1371/journal.pone.0107427 　

    ISSN： 1932-6203

  144. Development of a PET/Cerenkov-light hybrid imaging system Peer-reviewed

    Seiichi Yamamoto, Fuka Hamamura, Tadashi Watabe, Hayato Ikeda, Yasukazu Kanai, Hiroshi Watabe, Katsuhiko Kato, Yoshimune Ogata, Jun Hatazawa

    MEDICAL PHYSICS　41　(9)　092504-092504　2014/09

    DOI： 10.1118/1.4893535 　

    ISSN： 0094-2405

  145. Rapid Synthesis of Zn-62-Labeled S-Glycosylated Porphyrin as Positron Emission Tomography Tracers for In Vivo PET Imaging Peer-reviewed

    Masato Tamura, Hirofumi Matsui, Shiho Hirohara, Kiyomi Kakiuchi, Masao Tanihara, Naruto Takahashi, Kozi Nakai, Yasukazu Kanai, Hiroshi Watabe, Jun Hatazawa

    CHEMISTRY LETTERS　43　(6)　778-780　2014/06

    DOI： 10.1246/cl.140056 　

    ISSN： 0366-7022

    eISSN： 1348-0715

  146. Radiolabeling of anti-VEGFR antibody and gamma camera imaging in rats Peer-reviewed

    Yasukazu Kanai, Mai Yoshikawa, Yohei Mukai, Naoki Okada, Hiroshi Watabe, Eku Shimosegawa, Shinsaku Nakagawa, Jun Hatazawa

    JOURNAL OF NUCLEAR MEDICINE　55　2014/05

    ISSN： 0161-5505

    eISSN： 1535-5667

  147. Three-layer GSO depth-of-interaction detector for high-energy gamma camera Peer-reviewed

    S. Yamamoto, H. Watabe, N. Kawachi, S. Fujimaki, K. Kato, J. Hatazawa

    Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment　743　124-129　2014/04/11

    DOI： 10.1016/j.nima.2014.01.011 　

    ISSN： 0168-9002

  148. Selective accumulation of [Zn-62]-labeled glycoconjugated porphyrins as multi-functional positron emission tomography tracers in cancer cells Peer-reviewed

    Masato Tamura, Hirofumi Matsui, Shiho Hirohara, Kiyomi Kakiuchi, Masao Tanihara, Naruto Takahashi, Kozi Nakai, Yasukazu Kanai, Hiroshi Watabe, Jun Hatazawa

    BIOORGANIC & MEDICINAL CHEMISTRY　22　(8)　2563-2570　2014/04

    DOI： 10.1016/j.bmc.2014.02.021 　

    ISSN： 0968-0896

    eISSN： 1464-3391

  149. Impact of cardiac support device combined with slow-release prostacyclin agonist in a canine ischemic cardiomyopathy model. International-journal Peer-reviewed

    Yasuhiko Kubota, Shigeru Miyagawa, Satsuki Fukushima, Atsuhiro Saito, Hiroshi Watabe, Takashi Daimon, Yoshiki Sakai, Toshiaki Akita, Yoshiki Sawa

    The Journal of thoracic and cardiovascular surgery　147　(3)　1081-7　2014/03

    DOI： 10.1016/j.jtcvs.2013.05.035 　

    ISSN： 0022-5223

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    BACKGROUND: The cardiac support device supports the heart and mechanically reduces left ventricular (LV) diastolic wall stress. Although it has been shown to halt LV remodeling in dilated cardiomyopathy, its therapeutic efficacy is limited by its lack of biological effects. In contrast, the slow-release synthetic prostacyclin agonist ONO-1301 enhances reversal of LV remodeling through biological mechanisms such as angiogenesis and attenuation of fibrosis. We therefore hypothesized that ONO-1301 plus a cardiac support device might be beneficial for the treatment of ischemic cardiomyopathy. METHODS: Twenty-four dogs with induced anterior wall infarction were assigned randomly to 1 of 4 groups at 1 week postinfarction as follows: cardiac support device alone, cardiac support device plus ONO-1301 (hybrid therapy), ONO-1301 alone, or sham control. RESULTS: At 8 weeks post-infarction, LV wall stress was reduced significantly in the hybrid therapy group compared with the other groups. Myocardial blood flow, measured by positron emission tomography, and vascular density were significantly higher in the hybrid therapy group compared with the cardiac support device alone and sham groups. The hybrid therapy group also showed the least interstitial fibrosis, the greatest recovery of LV systolic and diastolic functions, assessed by multidetector computed tomography and cardiac catheterization, and the lowest plasma N-terminal pro-B-type natriuretic peptide levels (P < .05). CONCLUSIONS: The combination of a cardiac support device and the prostacyclin agonist ONO-1301 elicited a greater reversal of LV remodeling than either treatment alone, suggesting the potential of this hybrid therapy for the clinical treatment of ischemia-induced heart failure.

  150. Pharmacokinetic challenges against brain diseases with PET Peer-reviewed

    Hiroshi Watabe, Keisuke Matsubara, Yoko Ikoma

    Nanotechnology: Concepts, Methodologies, Tools, and Applications　2-3　997-1007　2014/02/28

    Publisher: IGI Global

    DOI： 10.4018/978-1-4666-5125-8.ch045 　

  151. Kinetic Models for PET/SPECT Imaging.

    Miho Shidahara, Hiroshi Watabe, Iwao Kanno

    Encyclopedia of Computational Neuroscience　2014

    Publisher: Springer

    DOI： 10.1007/978-1-4614-7320-6_526-1 　

  152. Development of a high-resolution YSO gamma camera system that employs 0.8-mm pixels Peer-reviewed

    Seiichi Yamamoto, Hiroshi Watabe, Yasukazu Kanai, Katsuhiko Kato, Jun Hatazawa

    Annals of Nuclear Medicine　28　(3)　232-240　2014

    Publisher: Springer-Verlag Tokyo

    DOI： 10.1007/s12149-013-0800-y 　

    ISSN： 1864-6433 0914-7187

  153. 解析技術の現状と展望

    渡部浩司

    インナービジョン　2014

  154. Development of an ultrahigh resolution Si-PM based PET system for small animals Peer-reviewed

    Seiichi Yamamoto, Hiroshi Watabe, Yasukazu Kanai, Tadashi Watabe, Katsuhiko Kato, Jun Hatazawa

    PHYSICS IN MEDICINE AND BIOLOGY　58　(21)　7875-7888　2013/11

    DOI： 10.1088/0031-9155/58/21/7875 　

    ISSN： 0031-9155

    eISSN： 1361-6560

  155. 対向型乳腺専用PET(PEM)による早期乳癌の検出能力の検討

    伊藤 正敏, 伊藤 繁記, 三宅 正泰, 田代 学, 渡部 浩司, 矢野 文月, 山本 誠一

    核医学　50　(3)　S222-S222　2013/09

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  156. 東北大学PEMの計数率補正とSUV表示の検討

    伊藤 繁記, 三宅 正泰, 渡部 浩司, 馬場 護, 伊藤 正敏, 山本 誠一

    核医学　50　(3)　S226-S226　2013/09

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  157. 小動物用PET/CTのLow dose CTシステムの使用経験

    堀次 元気, 渡部 直史, 渡部 浩司, 池田 隼人, 仲 定弘, 金井 泰和, 石橋 愛, 礒橋 佳也子, 加藤 弘樹, 下瀬川 恵久, 畑澤 順

    核医学　50　(3)　S211-S211　2013/09

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  158. 正常ラットにおけるアセチルコリンエステラーゼ阻害薬の全身動態 11C-Donepezil PET

    渡部 直史, 仲 定宏, 金井 泰和, 下瀬川 恵久, 堀次 元気, 池田 隼人, 持田 郁子, 礒橋 佳也子, 加藤 弘樹, 渡部 浩司, 畑澤 順

    核医学　50　(3)　S212-S212　2013/09

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  159. 15Oガス定常吸入法での動脈採血法と心プールからの画像的定量法の比較 小動物用PETを用いたラットでの評価

    松永 恵子, 渡部 直史, 堀次 元気, 池田 隼人, 金井 泰和, 下瀬川 恵久, 石橋 愛, 礒橋 佳也子, 加藤 弘樹, 渡部 浩司, 畑澤 順

    核医学　50　(3)　S213-S213　2013/09

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  160. Biodistribution of I-125-labeled polymeric vaccine carriers after subcutaneous injection Peer-reviewed

    Riki Toita, Yasukazu Kanai, Hiroshi Watabe, Kenshi Nakao, Seiichi Yamamoto, Jun Hatazawa, Mitsuru Akashi

    BIOORGANIC & MEDICINAL CHEMISTRY　21　(17)　5310-5315　2013/09

    DOI： 10.1016/j.bmc.2013.06.021 　

    ISSN： 0968-0896

  161. GLUT1の発現亢進を介しCD36欠損マウスの心筋グルコース取り込みは亢進する

    中谷 和弘, 渡部 直史, 増田 大作, 下瀬川 恵久, 渡部 浩司, 大濱 透, 外山 裕美子, 西田 誠, 小室 一成, 畑澤 順, 山下 静也

    日本動脈硬化学会総会プログラム・抄録集　45回　209-209　2013/06

    Publisher: (一社)日本動脈硬化学会

    ISSN： 1347-7099

  162. Development of an ultrahigh-resolution Si-PM-based dual-head GAGG coincidence imaging system Peer-reviewed

    Seiichi Yamamoto, Hiroshi Watabe, Yasukazu Kanai, Katsuhiko Kato, Jun Hatazawa

    NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT　703　(1)　183-189　2013/03

    DOI： 10.1016/j.nima.2012.11.098 　

    ISSN： 0168-9002

  163. Rapid quantitative CBF and CMRO2 measurements from a single PET scan with sequential administration of dual O-15-labeled tracers Peer-reviewed

    Nobuyuki Kudomi, Yoshiyuki Hirano, Kazuhiro Koshino, Takuya Hayashi, Hiroshi Watabe, Kazuhito Fukushima, Hiroshi Moriwaki, Noboru Teramoto, Koji Iihara, Hidehiro Iida

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　33　(3)　440-448　2013/03

    DOI： 10.1038/jcbfm.2012.188 　

    ISSN： 0271-678X

    eISSN： 1559-7016

  164. Quantitative Evaluation of Cerebral Blood Flow and Oxygen Metabolism in Normal Anesthetized Rats: O-15-Labeled Gas Inhalation PET with MRI Fusion Peer-reviewed

    Tadashi Watabe, Eku Shimosegawa, Hiroshi Watabe, Yasukazu Kanai, Kohei Hanaoka, Takashi Ueguchi, Kayako Isohashi, Hiroki Kato, Mitsuaki Tatsumi, Jun Hatazawa

    JOURNAL OF NUCLEAR MEDICINE　54　(2)　283-290　2013/02

    DOI： 10.2967/jnumed.112.109751 　

    ISSN： 0161-5505

    eISSN： 1535-5667

  165. Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma Peer-reviewed

    Takuya Hayashi, Masamitsu Shimazawa, Hiroshi Watabe, Takayuki Ose, Yuta Inokuchi, Yasushi Ito, Hajime Yamanaka, Shin-Ichi Urayama, Yasuyoshi Watanabe, Hideaki Hara, Hirotaka Onoe

    Molecular Neurodegeneration　8　(1)　2013

    DOI： 10.1186/1750-1326-8-4 　

    ISSN： 1750-1326

  166. Optimization of [C-11]methionine PET study: appropriate scan timing and effect of plasma amino acid concentrations on the SUV Peer-reviewed

    Kayako Isohashi, Eku Shimosegawa, Hiroki Kato, Yasukazu Kanai, Sadahiro Naka, Koichi Fujino, Hiroshi Watabe, Jun Hatazawa

    EJNMMI RESEARCH　3　(1)　27　2013

    DOI： 10.1186/2191-219X-3-27 　

    ISSN： 2191-219X

  167. Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques Peer-reviewed

    Takuya Hayashi, Shohei Wakao, Masaaki Kitada, Takayuki Ose, Hiroshi Watabe, Yasumasa Kuroda, Kanae Mitsunaga, Dai Matsuse, Taeko Shigemoto, Akihito Ito, Hironobu Ikeda, Hidenao Fukuyama, Hirotaka Onoe, Yasuhiko Tabata, Mari Dezawa

    JOURNAL OF CLINICAL INVESTIGATION　123　(1)　272-284　2013/01

    DOI： 10.1172/JCI62516 　

    ISSN： 0021-9738

  168. シリコンフォトマルを用いた動物用超高分解能 PET 装置の開発

    山本誠一, 渡部浩司, 金井泰和, 渡部直史, 加藤克彦, 畑澤順

    JSMI Report　2013

  169. 正常人の「脳血流量/脳血液量」の比について

    綿谷 朋大, 佐々 暢亜, 佐竹 祐人, 萩 美里, 渡部 浩司, 加藤 弘樹, 下瀬川 恵久, 畑澤 順

    核医学　49　(4)　434-435　2012/11

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  170. もやもや病の「脳血流量/脳血液量」の比について

    佐々 暢亜, 佐竹 祐人, 萩 美里, 綿谷 朋大, 渡部 浩司, 加藤 弘樹, 下瀬川 恵久, 畑澤 順

    核医学　49　(4)　435-435　2012/11

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  171. 高齢者一卵性双生児の脳FDG-PET 脳機能の遺伝的要因と後天的要因の解析

    渡辺 晋一郎, 礒橋 佳也子, 加藤 弘樹, 下瀬川 恵久, 金井 泰和, 渡部 浩司, 本多 智佳, 加藤 憲司, 早川 和生, 畑澤 順

    脳循環代謝　24　(1)　185-185　2012/11

    Publisher: (一社)日本脳循環代謝学会

    ISSN： 0915-9401

    eISSN： 2188-7519

  172. Performance comparison of high quantum efficiency and normal quantum efficiency photomultiplier tubes and position sensitive photomultiplier tubes for high resolution PET and SPECT detectors Peer-reviewed

    Seiichi Yamamoto, Hiroshi Watabe, Katsuhiko Kato, Jun Hatazawa

    MEDICAL PHYSICS　39　(11)　6900-6907　2012/11

    DOI： 10.1118/1.4760991 　

    ISSN： 0094-2405

  173. Development of a flexible optical fiber based high resolution integrated PET/MRI system Peer-reviewed

    Seiichi Yamamoto, Hiroshi Watabe, Yasukazu Kanai, Tadashi Watabe, Masaaki Aoki, Eiji Sugiyama, Katsuhiko Kato, Jun Hatazawa

    MEDICAL PHYSICS　39　(11)　6660-6671　2012/11

    DOI： 10.1118/1.4757911 　

    ISSN： 0094-2405

  174. Monte Carlo estimation of scatter effects on quantitative myocardial blood flow and perfusable tissue fraction using 3D-PET and O-15-water Peer-reviewed

    Yoshiyuki Hirano, Kazuhiro Koshino, Hiroshi Watabe, Kazuhito Fukushima, Hidehiro Iida

    PHYSICS IN MEDICINE AND BIOLOGY　57　(22)　7481-7492　2012/11

    DOI： 10.1088/0031-9155/57/22/7481 　

    ISSN： 0031-9155

  175. 多目的合成装置UG-M1を用いた18F-FDG合成条件の検討

    金井 泰和, 渡部 浩司, 仲 定宏, 三宅 義徳, 礒橋 佳也子, 加藤 弘樹, 下瀬川 恵久, 畑澤 順

    核医学　49　(3)　S248-S248　2012/08

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  176. 微量試料の放射能濃度測定の精度検証

    森田 敬裕, 渡部 直史, 渡部 浩司, 金井 泰和, 礒橋 佳也子, 加藤 弘樹, 下瀬川 恵久, 畑澤 順

    核医学　49　(3)　S253-S253　2012/08

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  177. 統計画像解析による脳SPECTの集積低下検出感度に関する吸収補正法の影響について

    加藤 弘樹, 石橋 愛, 礒橋 佳也子, 金井 泰和, 巽 光朗, 渡部 浩司, 下瀬川 恵久, 畑澤 順

    核医学　49　(3)　S274-S274　2012/08

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  178. Quantification of regional cerebral blood flow in rats using an arteriovenous shunt and micro-PET Peer-reviewed

    Takayuki Ose, Hiroshi Watabe, Takuya Hayashi, Nobuyuki Kudomi, Masaaki Hikake, Hajime Fukuda, Noboru Teramoto, Yasuyoshi Watanabe, Hirotaka Onoe, Hidehiro Iida

    NUCLEAR MEDICINE AND BIOLOGY　39　(5)　730-741　2012/07

    DOI： 10.1016/j.nucmedbio.2011.11.004 　

    ISSN： 0969-8051

  179. Effects of patient movement on measurements of myocardial blood flow and viability in resting O-15-water PET studies Peer-reviewed

    Kazuhiro Koshino, Hiroshi Watabe, Junichiro Enmi, Yoshiyuki Hirano, Tsutomu Zeniya, Shinji Hasegawa, Takuya Hayashi, Shigeru Miyagawa, Yoshiki Sawa, Jun Hatazawa, Hidehiro Iida

    JOURNAL OF NUCLEAR CARDIOLOGY　19　(3)　524-533　2012/06

    DOI： 10.1007/s12350-012-9522-0 　

    ISSN： 1071-3581

    eISSN： 1532-6551

  180. Development of an ultrahigh-resolution Si-PM-based dual-head GAGG coincidence imaging system

    Seiichi Yamamoto, Hiroshi Watabe, Yasukazu Kanai, Masao Imaizumi, Tadashi Watabe, Eku Shimosegawa, Jun Hatazawa

    JOURNAL OF NUCLEAR MEDICINE　53　2012/05

    ISSN： 0161-5505

    eISSN： 1535-5667

  181. Effect of radiofrequency (RF) shielding in a silicon-photomultiplier PET/MRI system

    Seiichi Yamamoto, Hiroshi Watabe, Yasukazu Kanai, Eku Shimosegawa, Jun Hatazawa

    JOURNAL OF NUCLEAR MEDICINE　53　2012/05

    ISSN： 0161-5505

    eISSN： 1535-5667

  182. 15O標識ガス定常吸入法によるラット脳血流・酸素代謝評価

    渡部 直史, 下瀬川 恵久, 渡部 浩司, 金井 泰和, 花岡 宏平, 上口 貴志, 今泉 昌男, 加藤 弘樹, 礒橋 佳也子, 巽 光朗, 畑澤 順

    JSMI Report　5　(2)　90-90　2012/05

    Publisher: 日本分子イメージング学会

    ISSN： 1882-6490

  183. Wavelet-based resolution recovery using an anatomical prior provides quantitative recovery for human population phantom PET [C-11]raclopride data Peer-reviewed

    M. Shidahara, C. Tsoumpas, C. J. McGinnity, T. Kato, H. Tamura, A. Hammers, H. Watabe, F. E. Turkheimer

    PHYSICS IN MEDICINE AND BIOLOGY　57　(10)　3107-3122　2012/05

    DOI： 10.1088/0031-9155/57/10/3107 　

    ISSN： 0031-9155

    eISSN： 1361-6560

  184. Intratumoral heterogeneity of F-18 FDG uptake differentiates between gastrointestinal stromal tumors and abdominal malignant lymphomas on PET/CT Peer-reviewed

    Tadashi Watabe, Mitsuaki Tatsumi, Hiroshi Watabe, Kayako Isohashi, Hiroki Kato, Masahiro Yanagawa, Eku Shimosegawa, Jun Hatazawa

    ANNALS OF NUCLEAR MEDICINE　26　(3)　222-227　2012/04

    DOI： 10.1007/s12149-011-0562-3 　

    ISSN： 0914-7187

  185. Development of a pixelated GSO gamma camera system with tungsten parallel hole collimator for single photon imaging Peer-reviewed

    S. Yamamoto, H. Watabe, Y. Kanai, E. Shimosegawa, J. Hatazawa

    MEDICAL PHYSICS　39　(2)　581-588　2012/02

    DOI： 10.1118/1.3673774 　

    ISSN： 0094-2405

  186. Wavelet-based resolution recovery using anatomical prior provides quantitative recovery for human population phantom PET [ 11C] raclopride data Peer-reviewed

    Miho Shidahara, Charalampos Tsoumpas, Colm McGinnity, Takashi Kato, Hajime Tamura, Alexander Hammers, Hiroshi Watabe, Federico E. Turkheimer

    IEEE Nuclear Science Symposium Conference Record　3097-3101　2012

    DOI： 10.1109/NSSMIC.2011.6152561 　

    ISSN： 1095-7863

  187. Conceptual design of high spatial-resolution SPECT system for human brain Peer-reviewed

    Tsutomu Zeniya, Yoshiyuki Hirano, Takanori Tominaga, Yuki Hori, Hiroshi Watabe, Tomonori Sakimoto, Antti Sohlberg, Kotaro Minato, Jun Hatazawa, Hidehiro Iida

    IEEE Nuclear Science Symposium Conference Record　3426-3428　2012

    DOI： 10.1109/NSSMIC.2011.6152624 　

    ISSN： 1095-7863

  188. Development of a high-sensitivity BGO well counter for small animal PET studies. Peer-reviewed

    Seiichi Yamamoto, Hiroshi Watabe, Yasukazu Kanai, Tadashi Watabe, Masao Imaizumi, Eku Shimosegawa, Jun Hatazawa

    Radiological physics and technology　5　(1)　59-62　2012/01

    DOI： 10.1007/s12194-011-0136-z 　

    More details Close

    In quantitative measurements of small animal PET studies, blood sampling is limited due to the small amounts of blood such animals can provide. In addition, injection doses are quite limited. In this situation, a high-sensitivity well counter would be useful for reducing the amount of the blood sample needed from small animals. Bismuth germinate (BGO) has a high stopping power for high-energy gamma rays compared to NaI(Tl), which is commonly used for conventional well counters. We have developed a BGO well counter and have tested it for blood-sampling measurements in small animals. The BGO well counter uses a square BGO block (59 × 59 × 50 mm) with a square open space (27 × 27 × 34 mm) in the center of the block. The BGO block was optically coupled to a 59-mm square-shaped photomultiplier tube (PMT). Signals from the PMT were digitally processed for the integration and energy window setting. The results showed that the energy spectrum of the BGO well counter measured with a Na-22 point source provided counts that were about 6 times higher for a 1022-keV (511 keV × 2) gamma peak than the spectrum of a 2-in. NaI(Tl) well counter. The relative sensitivity of the developed BGO well counter was 3.4 times higher than that of a NaI(Tl) well counter. The time activity curve of arterial blood was obtained successfully with the BGO well counter for a F-18-FDG study on rat. The BGO well counter will contribute to reducing the amount of sampled blood and to improving the throughput of quantitative measurements in small animal PET studies.

  189. Simultaneous imaging using Si-PM-based PET and MRI for development of an integrated PET/MRI system Peer-reviewed

    Seiichi Yamamoto, Tadashi Watabe, Hiroshi Watabe, Masaaki Aoki, Eiji Sugiyama, Masao Imaizumi, Yasukazu Kanai, Eku Shimosegawa, Jun Hatazawa

    PHYSICS IN MEDICINE AND BIOLOGY　57　(2)　N1-N13　2012/01

    DOI： 10.1088/0031-9155/57/2/N1 　

    ISSN： 0031-9155

  190. 大阪大学大学院医学系研究科における医用画像工学研究

    佐藤嘉伸, 渡部浩司, 村瀬研也

    Medical Imaging Technology　2012

  191. Development of a high-resolution Si-PM-based gamma camera system Peer-reviewed

    Seiichi Yamamoto, Hiroshi Watabe, Yasukazu Kanai, Masao Imaizumi, Tadashi Watabe, Eku Shimosegawa, Jun Hatazawa

    PHYSICS IN MEDICINE AND BIOLOGY　56　(23)　7555-7567　2011/12

    DOI： 10.1088/0031-9155/56/23/014 　

    ISSN： 0031-9155

  192. 15O標識ガス定常吸入法によるラット脳血流・酸素代謝評価

    渡部 直史, 下瀬川 恵久, 渡部 浩司, 金井 泰和, 加藤 弘樹, 今泉 昌男, 巽 光朗, 礒橋 佳也子, 花岡 宏平, 上口 貴志, 畑澤 順

    脳循環代謝　23　(1)　119-119　2011/11

    Publisher: (一社)日本脳循環代謝学会

    ISSN： 0915-9401

    eISSN： 2188-7519

  193. Three-dimensional quantitation of regional cerebral blood flow in mice using a high-resolution pinhole SPECT system and 123I-iodoamphetamine Peer-reviewed

    Tsutomu Zeniya, Hiroshi Watabe, Takuya Hayashi, Takayuki Ose, Kazunori Myojin, Akihiko Taguchi, Akihide Yamamoto, Noboru Teramoto, Masaru Kanagawa, Yoshihiro Yamamichi, Hidehiro Iida

    Nuclear Medicine and Biology　38　(8)　1157-1164　2011/11

    DOI： 10.1016/j.nucmedbio.2011.04.007 　

    ISSN： 0969-8051 1872-9614

    eISSN： 1872-9614

  194. Performance comparison of Si-PM-based block detectors with different pixel sizes for an ultrahigh-resolution small-animal PET system Peer-reviewed

    Seiichi Yamamoto, Hiroshi Watabe, Jun Hatazawa

    PHYSICS IN MEDICINE AND BIOLOGY　56　(20)　N227-N236　2011/10

    DOI： 10.1088/0031-9155/56/20/N02 　

    ISSN： 0031-9155

  195. 小動物用ピンホールSPECT装置の回転半径と体軸方向の有効視野の関係に関する検討

    志田原 美保, 犬伏 正幸, 田村 元, 渡部 浩司, 村井 知佳, 小泉 満, 佐賀 恒夫

    核医学　48　(3)　S267-S267　2011/09

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  196. 画像再構成法および吸収補正法が、脳SPECT正常データベースにおけるvoxel値のばらつきに与える影響について

    加藤 弘樹, 下瀬川 恵久, 今泉 昌男, 礒橋 佳也子, 巽 光朗, 渡部 浩司, 金井 泰和, 畑澤 順

    核医学　48　(3)　S254-S255　2011/09

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  197. 健常人におけるC-11 PBR28の全身ダイナミックイメージング

    今泉 昌男, 金井 泰和, 仲 定宏, 礒橋 佳也子, 加藤 弘樹, 巽 光朗, 渡部 直史, 渡辺 晋一郎, 渡部 浩司, 下瀬川 恵久, 畑澤 順

    核医学　48　(3)　S289-S290　2011/09

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  198. PET・臨床 18kDa Translocator Proteinイメージング 脳血管障害患者への臨床応用に向けて

    今泉 昌男, 藤中 俊之, 中村 元, 金井 泰和, 仲 定宏, 加藤 弘樹, 渡部 直史, 礒橋 佳也子, 大楠 郁子, 花本 敦, 渡部 浩司, 下瀬川 恵久, 吉峰 俊樹, 畑澤 順

    脳循環代謝　22　(2)　65-71　2011/08

    Publisher: (一社)日本脳循環代謝学会

    ISSN： 0915-9401

    eISSN： 2188-7519

  199. Sensitivity of Kinetic Macro Parameters to Changes in Dopamine Synthesis, Storage, and Metabolism: A Simulation Study for [F-18]FDOPA PET By a Model With Detailed Dopamine Pathway Peer-reviewed

    Keisuke Matsubara, Hiroshi Watabe, Yoshitaka Kumakura, Takuya Hayashi, Christopher J. Endres, Kotaro Minato, Hidehiro Iida

    SYNAPSE　65　(8)　751-762　2011/08

    DOI： 10.1002/syn.20899 　

    ISSN： 0887-4476

  200. Interference between PET and MRI sub-systems in a silicon-photomultiplier-based PET/MRI system Peer-reviewed

    Seiichi Yamamoto, Hiroshi Watabe, Yasukazu Kanai, Masaaki Aoki, Eiji Sugiyama, Tadashi Watabe, Masao Imaizumi, Eku Shimosegawa, Jun Hatazawa

    PHYSICS IN MEDICINE AND BIOLOGY　56　(13)　4147-4159　2011/07

    DOI： 10.1088/0031-9155/56/13/026 　

    ISSN： 0031-9155

  201. Development of a high resolution Si-PM based compact gamma camera system

    Seiichi Yamamoto, Hiroshi Watabe, Tadashi Watabe, Yasukazu Kanai, Eku Shimosegawa, Jun Hatazawa

    JOURNAL OF NUCLEAR MEDICINE　52　2011/05

    ISSN： 0161-5505

    eISSN： 1535-5667

  202. Development of a flexible optical fiber based high resolution integrated PET/MRI system: iPET/MRI II

    Seiichi Yamamoto, Masaaki Aoki, Eiji Sugiyama, Hiroshi Watabe, Tadashi Watabe, Yasukazu Kanai, Masao Imaizumi, Eku Shimosegawa, Jun Hatazawa

    JOURNAL OF NUCLEAR MEDICINE　52　2011/05

    ISSN： 0161-5505

    eISSN： 1535-5667

  203. High resolution coincidence imaging systems using Si-PM based LGSO block detectors

    Seiichi Yamamoto, Tadashi Watabe, Hiroshi Watabe, Yasukazu Kanai, Eku Shimosegawa, Jun Hatazawa

    JOURNAL OF NUCLEAR MEDICINE　52　2011/05

    ISSN： 0161-5505

    eISSN： 1535-5667

  204. 拡散テンソル画像でみた神経変性動態 緑内障視神経障害モデル動物における観察 Peer-reviewed

    林 拓也, 原 英彰, 嶋澤 雅光, 井口 勇太, 伊藤 保志, 合瀬 恭幸, 渡部 浩司, 飯田 英博, 山中 創, 渡辺 恭良, 尾上 浩隆

    JSMI Report　4　(2)　92-92　2011/05

    Publisher: 日本分子イメージング学会

    ISSN： 1882-6490

  205. A temperature-dependent gain control system for improving the stability of Si-PM-based PET systems Peer-reviewed

    Seiichi Yamamoto, Junkichi Satomi, Tadashi Watabe, Hiroshi Watabe, Yasukazu Kanai, Masao Imaizumi, Eku Shimosegawa, Jun Hatazawa

    PHYSICS IN MEDICINE AND BIOLOGY　56　(9)　2873-2882　2011/05

    DOI： 10.1088/0031-9155/56/9/015 　

    ISSN： 0031-9155

  206. Imaging of carbon translocation to fruit using carbon-11-labeled carbon dioxide and positron emission tomography Peer-reviewed

    Naoki Kawachi, Kaori Kikuchi, Nobuo Suzui, Satomi Ishii, Shu Fujimaki, Noriko S. Ishioka, Hiroshi Watabe

    IEEE Transactions on Nuclear Science　58　(2)　395-399　2011/04

    DOI： 10.1109/TNS.2011.2113192 　

    ISSN： 0018-9499

  207. Pharmacokinetic challenges against brain diseases with PET Peer-reviewed

    Hiroshi Watabe, Keisuke Matsubara, Yoko Ikoma

    Early Detection and Rehabilitation Technologies for Dementia: Neuroscience and Biomedical Applications　145-155　2011

    Publisher: IGI Global

    DOI： 10.4018/978-1-60960-559-9.ch019 　

  208. Wavelet-based resolution recovery using anatomical prior provides quantitative recovery for human population phantom PET [C-11]raclopride data Peer-reviewed

    Miho Shidahara, Charalampos Tsoumpas, Colm McGinnity, Takashi Kato, Hajime Tamura, Alexander Hammers, Hiroshi Watabe, Federico E. Turkheimer

    2011 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (NSS/MIC)　3097-3101　2011

    ISSN： 1082-3654

  209. Conceptual Design of High Spatial-Resolution SPECT System for Human Brain Peer-reviewed

    Tsutomu Zeniya, Yoshiyuki Hirano, Takanori Tominaga, Yuki Hori, Hiroshi Watabe, Tomonori Sakimoto, Antti Sohlberg, Kotaro Minato, Jun Hatazawa, Hidehiro Iida

    2011 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (NSS/MIC)　3426-3428　2011

    ISSN： 1082-3654

  210. Quantitative analysis of amyloid β deposition in patients with Alzheimer's disease using positron emission tomography

    Manabu Tashiro, Nobuyuki Okamura, Shoichi Watanuki, Shozo Furumoto, Katsutoshi Furukawa, Yoshihito Funaki, Ren Iwata, Yukitsuka Kudo, Hiroyuki Arai, Hiroshi Watabe, Kazuhiko Yanai

    Early Detection and Rehabilitation Technologies for Dementia: Neuroscience and Biomedical Applications　220-230　2011

    Publisher: IGI Global

    DOI： 10.4018/978-1-60960-559-9.ch029 　

  211. PET・臨床 18KDa Translocator Proteinイメージング 脳血管障害患者への臨床応用に向けて

    今泉 昌男, 藤中 俊之, 中村 元, 金井 泰和, 仲 定宏, 加藤 弘樹, 渡部 直史, 礒橋 佳也子, 大楠 郁子, 花本 敦, 渡部 浩司, 下瀬川 恵久, 吉峰 俊樹, 畑澤 順

    脳循環代謝　22　(1)　85-85　2010/11

    Publisher: (一社)日本脳循環代謝学会

    ISSN： 0915-9401

    eISSN： 2188-7519

  212. Multicenter Evaluation of a Standardized Protocol for Rest and Acetazolamide Cerebral Blood Flow Assessment Using a Quantitative SPECT Reconstruction Program and Split-Dose I-123-Iodoamphetamine Peer-reviewed

    Hidehiro Iida, Jyoji Nakagawara, Kohei Hayashida, Kazuhito Fukushima, Hiroshi Watabe, Kazuhiro Koshino, Tsutomu Zeniya, Stefan Eberl

    JOURNAL OF NUCLEAR MEDICINE　51　(10)　1624-1631　2010/10

    DOI： 10.2967/jnumed.110.078352 　

    ISSN： 0161-5505

    eISSN： 1535-5667

  213. Development of a Si-PM-based high-resolution PET system for small animals Peer-reviewed

    Seiichi Yamamoto, Masao Imaizumi, Tadashi Watabe, Hiroshi Watabe, Yasukazu Kanai, Eku Shimosegawa, Jun Hatazawa

    PHYSICS IN MEDICINE AND BIOLOGY　55　(19)　5817-5831　2010/10

    DOI： 10.1088/0031-9155/55/19/013 　

    ISSN： 0031-9155

  214. 13N-Ammonia PETの3D収集法による心筋血流量及び心筋血流予備能の正常値

    木曽 啓祐, 下瀬川 恵久, 藤埜 浩一, 渡部 浩司, 金井 泰和, 畑澤 順

    核医学　47　(3)　366-366　2010/09

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  215. Basis Funciton法を用いたアンモニアPET心筋血流画像の定量

    渡部 浩司, 木曽 啓祐, 下瀬川 恵久, 金井 泰和, 藤埜 浩一, 畑澤 順

    核医学　47　(3)　366-366　2010/09

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  216. SPECT/CT装置の正常CBF定量値 PET-CBFとの比較による新しい画像再構成法の検証

    下瀬川 恵久, 藤埜 浩一, 渡部 浩司, 加藤 弘樹, 今泉 昌男, 渡部 直史, 礒橋 佳也子, 畑澤 順

    核医学　47　(3)　396-396　2010/09

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  217. SPECT/CT装置による正常脳血流定性画像 再構成・吸収補正法の違いによる従来法との比較

    渡部 直史, 下瀬川 恵久, 渡部 浩司, 加藤 弘樹, 今泉 昌男, 巽 光朗, 大楠 郁子, 礒橋 佳也子, 畑澤 順

    核医学　47　(3)　412-413　2010/09

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  218. [5-11C-methoxy]donepezil-PETによるアセチルコリンエステラーゼの定量解析

    平岡宏太良, 岡村信行, 船木善仁, 四月朔日聖一, 田代学, 谷内一彦, 渡部浩司

    核医学　47　(3)　389-389　2010/09

    Publisher:

    ISSN： 0022-7854

    eISSN： 2189-9932

  219. Long-term observation of auto-cell transplantation in non-human primate reveals safety and efficiency of bone marrow stromal cell-derived Schwann cells in peripheral nerve regeneration Peer-reviewed

    Shohei Wakao, Takuya Hayashi, Masaaki Kitada, Misaki Kohama, Dai Matsue, Noboru Teramoto, Takayuki Ose, Yutaka Itokazu, Kazuhiro Koshino, Hiroshi Watabe, Hidehiro Iida, Tomoaki Takamoto, Yasuhiko Tabata, Mari Dezawa

    EXPERIMENTAL NEUROLOGY　223　(2)　537-547　2010/06

    DOI： 10.1016/j.expneurol.2010.01.022 　

    ISSN： 0014-4886

  220. Optimization of transmission scan duration for O-15 PET study with sequential dual tracer administration using N-index Peer-reviewed

    Nobuyuki Kudomi, Hiroshi Watabe, Takuya Hayashi, Hisashi Oka, Yoshinori Miyake, Hidehiro Iida

    ANNALS OF NUCLEAR MEDICINE　24　(5)　413-420　2010/06

    DOI： 10.1007/s12149-010-0374-x 　

    ISSN： 0914-7187

  221. Evaluation of an experimental model of myocardial infarction on inbred strain miniature pigs using 15O-labeled compounds and cardiac PET Peer-reviewed

    Koshino Kazuhiro, Teramoto Noboru, Fukuda Hajime, Hashikawa Yoshiko, Ishikane Shin, Hikake Masaaki, Watabe Hiroshi, Zeniya Tsutomu, Ikeda Tomoaki, Iida Hidehiro

    JOURNAL OF NUCLEAR MEDICINE　51　2010/05

    ISSN： 0161-5505

    eISSN： 1535-5667

  222. Evaluation of a new image reconstruction for high resolution and quantification in I-123 brain SPECT Peer-reviewed

    Zeniya Tsutomu, Sakimoto Tomonori, Ishida Kenji, Hirano Yoshiyuki, Watabe Hiroshi, Sohlberg Antti, Minato Kotaro, Iida Hidehiro

    JOURNAL OF NUCLEAR MEDICINE　51　2010/05

    ISSN： 0161-5505

    eISSN： 1535-5667

  223. Evaluation of the Quantitative Accuracy of a Novel Image Reconstruction Method with Monte Carlo-Based Scatter Compensation and Collimator Blurring Compensation for Brain SPECT

    SAKIMOTO Tomonori, ZENIYA Tsutomu, ISHIDA Kenji, WATABE Hiroshi, HIRANO Yoshiyuki, SOHLBERG Antti, MINATO Kotaro, IIDA Hidehiro

    Medical Imaging Technology　28　(2)　135-144　2010/03/25

    Publisher: 日本医用画像工学会

    DOI： 10.11409/mit.28.135 　

    ISSN： 0288-450X

  224. Measurement of density and affinity for dopamine D-2 receptors by a single positron emission tomography scan with multiple injections of [C-11]raclopride Peer-reviewed

    Yoko Ikoma, Hiroshi Watabe, Takuya Hayashi, Yoshinori Miyake, Noboru Teramoto, Kotaro Minato, Hidehiro Iida

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　30　(3)　663-673　2010/03

    DOI： 10.1038/jcbfm.2009.239 　

    ISSN： 0271-678X

  225. Evaluation of Bias of the Influx Constant Estimated by Patlak Analysis for [^<18>F]FDOPA PET : Influence of Metabolites for [^<18>F]FDOPA

    MATSUBARA kEISUKE, WATABE Hiroshi, HAYASHI Takuya, MINATO Kotaro, IIDA Hidehiro

    Transactions of Japanese Society for Medical and Biological Engineering　48　(1)　66-74　2010/02/10

    Publisher: 公益社団法人 日本生体医工学会

    DOI： 10.11239/jsmbe.48.66 　

    ISSN： 1347-443X

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    Patlak analysis, which estimates the net FDOPA influx constant (&lt;i&gt;K&lt;/i&gt;&lt;sub&gt;i&lt;/sub&gt;) by linear regression of data acquired from [&lt;sup&gt;18&lt;/sup&gt;F] FDOPA PET study, is widely employed in the diagnosis of neurological disorder, such as Parkinson&#039;s disease. In &lt;i&gt;K&lt;/i&gt;&lt;sub&gt;i&lt;/sub&gt; estimation by Patlak analysis, it is assumed that the metabolites of radioligand do not diffuse out of the tissue during PET scan. However, [&lt;sup&gt;18&lt;/sup&gt;F] F-Dopamine, synthesized from [&lt;sup&gt;18&lt;/sup&gt;F] FDOPA, is rapidly metabolized and its metabolites diffuse from the tissue. We aimed at the evaluation of the effect of dopamine metabolism and the clearance of its metabolites on &lt;i&gt;K&lt;/i&gt;&lt;sub&gt;i&lt;/sub&gt; estimated by Patlak analysis. For this purpose, we developed a model describing the detailed pathway of dopamine kinetics in the striatum, and a standard time-activity curve (TAC) was generated based on this model and [&lt;sup&gt;18&lt;/sup&gt;F] FDOPA PET data of a monkey. And TACs in case of altering the dopamine metabolism or the clearance of its metabolites were simulated. Then, we evaluated &lt;i&gt;K&lt;/i&gt;&lt;sub&gt;i&lt;/sub&gt; values estimated by Patlak analysis for these simulated TACs. &lt;i&gt;K&lt;/i&gt;&lt;sub&gt;i&lt;/sub&gt; was increased when the dopamine metabolism to DOPAC (&lt;i&gt;k&lt;/i&gt;&lt;sub&gt;9&lt;/sub&gt;&lt;sup&gt;dopac&lt;/sup&gt;) and the clearance of DOPAC and HVA (&lt;i&gt;k&lt;/i&gt;&lt;sub&gt;11&lt;/sub&gt;&lt;sup&gt;dopac&lt;/sup&gt;, &lt;i&gt;k&lt;/i&gt;&lt;sub&gt;11&lt;/sub&gt;&lt;sup&gt;hva&lt;/sup&gt;) were altered. The results suggest that &lt;i&gt;K&lt;/i&gt;&lt;sub&gt;i&lt;/sub&gt; could be biased by the influence of the metabolism of dopamine and clearance of its metabolites. Therefore, it is important to consider these biases in the interpretation of &lt;i&gt;K&lt;/i&gt;&lt;sub&gt;i&lt;/sub&gt; value estimated Patlak analysis.

  226. [18F]FDOPA PETデータのPatlak解析により推定された取り込み定数のバイアス評価 [18F]FDOPA代謝産物の影響 Peer-reviewed

    松原 佳亮, 渡部 浩司, 林 拓也, 湊 小太郎, 飯田 秀博

    生体医工学　48　(1)　66-73　2010/02

    Publisher: (公社)日本生体医工学会

    ISSN： 1347-443X

    eISSN： 1881-4379

  227. Quantification of regional myocardial oxygen metabolism in normal pigs using positron emission tomography with injectable O-15-O-2 Peer-reviewed

    Takashi Temma, Hidehiro Iida, Takuya Hayashi, Noboru Teramoto, Youichiro Ohta, Nobuyuki Kudomi, Hiroshi Watabe, Hideo Saji, Yasuhiro Magata

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　37　(2)　377-385　2010/02

    DOI： 10.1007/s00259-009-1262-2 　

    ISSN： 1619-7070

  228. Evaluation of Quantitative Accuracy of a Novel Image Reconstruction of SPECT with Monte Carlo-Based Scatter Compensation and Collimator Blurring Compensation

    SAKIMOTO Tomonori, ZENIYA Tsutomu, WATABE Hiroshi, SOHLBERG Antti, ISHIDA Kenji, HIRANO Yoshiyuki, MINATO Kotaro, IIDA Hidehiro

    IEICE technical report　109　(407)　13-18　2010/01/21

    Publisher: 一般社団法人電子情報通信学会

    ISSN： 0913-5685

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    Recently we developed a novel SPECT image reconstruction method that includes attenuation compensation(AC), collimator-detector response compensation(CDRC)and Monte Carlo-based scatter compensation(MCSC). The aim of this study was to quantitatively evaluate our reconstruction method for brain SPECT by phantom experiments with ^&lt;99m&gt;Tc. We performed the following experiments using a SPECT camera with LEHR parallel-hole collimator(GCA-7200A, Toshiba, Japan): (1)measurement of spatial resolution with line sources, (2)evaluation of quantitation with pyramid phantom, eccentric ring phantom, 2D brain phantom and 3D phantom. These results suggested that our reconstruction algorithm with AC, MCSC and CDRC was valid to improve resolution and quantitation in brain SPECT.

  229. Sensitivity of FDOPA kinetic macro-parameters to changes in Parkinson's disease: Evaluation for noise influence in [18F]FDOPA PET data. Peer-reviewed

    Keisuke Matsubara, Hiroshi Watabe, Takuya Hayashi 0002, Kotaro Minato, Hidehiro Iida

    NeuroImage　52　(Supplement-1)　S171-171　2010

    DOI： 10.1016/j.neuroimage.2010.04.139 　

    ISSN： 1053-8119

    eISSN： 1095-9572

  230. Quantitative Analysis of Donepezil Binding to Acetylcholinesterase using PET and [5-11C-methoxy]donepezil.

    Hiraoka K, Okamura N, Funaki Y, Watanuki S, Tashiro M, Kato M, Hayashi A, Hosokai Y, Yamasaki H, Fujii T, Mori E, Yanai K, Watabe H

    Proceedings of 13th International Symposium of Tohoku University Global COE Program Nano-Biomedical Engineering Education and Research Network Centre.　12-13　2010

  231. Development of motion correction technique for cardiac O-15-water PET study using an optical motion tracking system Peer-reviewed

    Kazuhiro Koshino, Hiroshi Watabe, Shinji Hasegawa, Takuya Hayashi, Jun Hatazawa, Hidehiro Iida

    ANNALS OF NUCLEAR MEDICINE　24　(1)　1-11　2010/01

    DOI： 10.1007/s12149-009-0323-8 　

    ISSN： 0914-7187

  232. Development of a Hardware-based Registration System for the Multimodal Medical Images by USB Cameras

    IWATA Michiaki, WATABE Hiroshi, KOSHINO Kazuhiro, YAMAMOTO Akihide, MINATO Kotaro, IIDA Hidehiro

    Transactions of Japanese Society for Medical and Biological Engineering　47　(6)　574-581　2009/12/10

    Publisher: Japanese Society for Medical and Biological Engineering

    DOI： 10.11239/jsmbe.47.574 　

    ISSN： 1347-443X

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    There are several medical imaging scanners and each modality has different aspect for visualizing inside of human body. By combining these images, diagnostic accuracy could be improved, and therefore, several attempts for multimodal image registration have been implemented. One popular approach is to use hybrid image scanners such as PET/CT and SPECT/CT. However, these hybrid scanners are expensive and not fully available. We developed multimodal image registration system with USB cameras, which is inexpensive and applicable to any combinations of existed conventional imaging scanners. The multiple USB cameras will determine the three dimensional positions of a patient while scanning. Using information of these positions and rigid body transformation, the acquired image is registered to the common coordinate which is shared with another scanner. For each scanner, reference marker is attached on gantry of the scanner. For observing the reference marker's position by the USB cameras, the location of the USB cameras can be arbitrary. In order to validate the system, we scanned a cardiac phantom with different positions by PET and MRI scanners. Using this system, images from PET and MRI were visually aligned, and good correlations between PET and MRI images were obtained after the registration. The results suggest this system can be inexpensively used for multimodal image registrations.

  233. A method to measure PET scatter fractions for daily quality control Peer-reviewed

    H. W. de Jong, M. Lubberink, H. Watabe, H. Iida, A. A. Lammertsma

    MEDICAL PHYSICS　36　(10)　4609-4615　2009/10

    DOI： 10.1118/1.3213096 　

    ISSN： 0094-2405

  234. Statistical Dynamic Imaging of RI-Labeled Tracer from List-Mode PET Data

    TANIMOTO Michiaki, WATABE Hiroshi, KURODA Yoshihiro, KURODA Tomohiro, OSHIRO Osamu

    Medical Imaging Technology　27　(4)　237-242　2009/09/25

    Publisher: The Japanese Society of Medical Imaging Technology

    DOI： 10.11409/mit.27.237 　

    ISSN： 0288-450X

  235. [11C]BF-227を用いた脳内アミロイド蓄積に関する動脈採血データを用いた定量解析

    田代学, 岡村信行, 熊谷和明, 古本祥三, 船木善仁, 木村裕一, 岩田錬, 工藤幸司, 渡部浩司, 荒井啓行, 谷内一彦

    核医学　46　(3)　262-262　2009/09

    Publisher:

    ISSN： 0022-7854

    eISSN： 2189-9932

  236. Evaluation of utility of asymmetric index for count-based oxygen extraction fraction on dual-tracer autoradiographic method for chronic unilateral brain infarction Peer-reviewed

    Katsuhiro Iwanishi, Hiroshi Watabe, Hiroshi Fujisaki, Takuya Hayashi, Yoshinori Miyake, Kotaro Minato, Masaki Naganuma, Toshiyuki Uehara, Chiaki Yokota, Hiroshi Moriwaki, Katsufumi Kajimoto, Kazuhito Fukushima, Kazuo Minematsu, Hidehiro Iida

    ANNALS OF NUCLEAR MEDICINE　23　(6)　533-539　2009/08

    DOI： 10.1007/s12149-009-0272-2 　

    ISSN： 0914-7187

  237. Influence of residual oxygen-15-labeled carbon monoxide radioactivity on cerebral blood flow and oxygen extraction fraction in a dual-tracer autoradiographic method Peer-reviewed

    Katsuhiro Iwanishi, Hiroshi Watabe, Takuya Hayashi, Yoshinori Miyake, Kotaro Minato, Hidehiro Iida

    ANNALS OF NUCLEAR MEDICINE　23　(4)　363-371　2009/06

    DOI： 10.1007/s12149-009-0243-7 　

    ISSN： 0914-7187

  238. Quantitative regional myocardial blood flow and coronary flow reserve in conscious rats assessed using split-dose 201TI and a dedicated dynamic Micro- SPECT system Peer-reviewed

    Hidehiro H. Iida, H. Iida, N. Teramoto, T. Zeniya, H. Watabe, K. Koshino, T. Ose

    EUROPEAN HEART JOURNAL SUPPLEMENTS　11　(B)　S57-S57　2009/05

    ISSN： 1520-765X

  239. A physiologic model for recirculation water correction in CMRO2 assessment with O-15(2) inhalation PET Peer-reviewed

    Nobuyuki Kudomi, Takuya Hayashi, Hiroshi Watabe, Noboru Teramoto, Rishu Piao, Takayuki Ose, Kazuhiro Koshino, Youichirou Ohta, Hidehiro Iida

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　29　(2)　355-364　2009/02

    DOI： 10.1038/jcbfm.2008.132 　

    ISSN： 0271-678X

  240. Performance estimation of high resolution SPECT for the human brain by Monte Carlo simulation of scintillation lights Peer-reviewed

    Y. Hirano, T. Zeniya, H. Watabe, H. Iida

    IEEE Nuclear Science Symposium Conference Record　3353-3356　2009

    DOI： 10.1109/NSSMIC.2009.5401755 　

    ISSN： 1095-7863

  241. Performance estimation of high resolution SPECT for the human brain by Monte Carlo simulation of scintillation lights Peer-reviewed

    Y. Hirano, T. Zeniya, H. Watabe, H. Iida

    IEEE Nuclear Science Symposium Conference Record　3602-3605　2009

    DOI： 10.1109/NSSMIC.2009.5401830 　

    ISSN： 1095-7863

  242. Conceptual design of high resolution and quantitative SPECT system for imaging a selected small roi of human brain Peer-reviewed

    Tsutomu Zeniya, Yoshiyuki Hirano, Tomonori Sakimoto, Kenji Ishida, Hiroshi Watabe, Noboru Teramoto, Hiroyuki Kudo, Kotaro Minato, Jun Hatazawa, Hidehiro Iida

    IEEE Nuclear Science Symposium Conference Record　3484-3486　2009

    DOI： 10.1109/NSSMIC.2009.5401794 　

    ISSN： 1095-7863

  243. Performance estimation of high resolution SPECT for the human brain by Monte Carlo simulation of scintillation lights Peer-reviewed

    Y. Hirano, T. Zeniya, H. Watabe, H. Iida

    2009 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-5　3602-3605　2009

    ISSN： 1082-3654

  244. Performance estimation of high resolution SPECT for the human brain by Monte Carlo simulation of scintillation lights Peer-reviewed

    Y. Hirano, T. Zeniya, H. Watabe, H. Iida

    2009 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-5　3353-3356　2009

    ISSN： 1082-3654

  245. Clinical Usability of a Compact High Resolution Detector for High Resolution and Quantitative SPECT Imaging in a Selected Small ROI Peer-reviewed

    Tsutomu Zeniya, Hiroshi Watabe, Hiroyuki Kudo, Yoshiyuki Hirano, Kotaro Minato, Hidehiro Iida

    2008 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (2008 NSS/MIC), VOLS 1-9　3531-+　2009

    ISSN： 1082-3654

  246. Combination of a High Resolution Detector with Small FOV and a Low Resolution Detector with Large FOV for High Resolution and Quantitative SPECT Peer-reviewed

    Tsutomu Zeniya, Hiroshi Watabe, Hiroyuki Kudo, Yoshiyuki Hirano, Kotaro Minato, Hidehiro Iida

    2008 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (2008 NSS/MIC), VOLS 1-9　4495-+　2009

    ISSN： 1082-3654

  247. Use of a clinical MRI scanner for preclinical research on rats Peer-reviewed

    Akihide Yamamoto, Hiroshi Sato, Jun-Ichiro Enmi, Kenji Ishida, Takayuki Ose, Atsuomi Kimura, Hideaki Fujiwara, Hiroshi Watabe, Takuya Hayashi, Hidehiro Iida

    Radiological Physics and Technology　2　(1)　13-21　2009/01

    DOI： 10.1007/s12194-008-0038-x 　

    ISSN： 1865-0333

  248. Conceptual Design of High Resolution and Quantitative SPECT System for Imaging a Selected Small ROI of human brain Peer-reviewed

    Tsutomu Zeniya, Yoshiyuki Hirano, Tomonori Sakimoto, Kenji Ishida, Hiroshi Watabe, Noboru Teramoto, Hiroyuki Kudo, Kotaro Minato, Jun Hatazawa, Hidehiro Iida

    2009 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-5　3484-+　2009

    DOI： 10.1109/NSSMIC.2009.5401794 　

    ISSN： 1082-3654

  249. Quantification of Amyloid β Deposition in Alzheimer's Disease Patients Using PET and [11C]BF-227.

    Tashiro M, Okamura N, Watanuki S, Furumoto S, Furukawa K, Funaki Y, Iwata R, Kudo Y, Arai H, Watabe H, Yanai K

    CYRIC Annual Report　2009　164-170　2009

    Publisher: Cyclotron and Radioisotope Center, Tohoku University

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    CYRIC Annual Report 2009

  250. Quantitative Analysis of Donepezil Binding to Acetylcholinesterase Using PET and [5-11C-methoxy]Donepezil.

    Hiraoka K, Okamura N, Funaki Y, Watanuki S, Tashiro M, Kato M, Hayashi A, Hosokai Y, Yamasaki H, Fujii T, Mori E, Yanai K, Watabe H

    CYRIC Annual Report　2009　171-173　2009

    Publisher: Cyclotron and Radioisotope Center, Tohoku University

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    CYRIC Annual Report 2009

  251. Quantitative analysis of donepezil binding to acetylcholinesterase using positron emission tomography and [5-11C-methoxy]donepezil. Peer-reviewed

    Kotaro Hiraoka, Nobuyuki Okamura, Yoshihito Funaki, Shoichi Watanuki, Manabu Tashiro, Motohisa Kato, Akiko Hayashi, Yoshiyuki Hosokai, Hiroshi Yamasaki, Toshikatsu Fujii, Etsuro Mori, Kazuhiko Yanai, Hiroshi Watabe

    NeuroImage　46　(3)　616-623　2009

    DOI： 10.1016/j.neuroimage.2009.03.006 　

    ISSN： 1053-8119

  252. Quantitative evaluation of changes in binding potential with a simplified reference tissue model and multiple injections of [11C]raclopride. Peer-reviewed

    Yoko Ikoma, Hiroshi Watabe, Takuya Hayashi 0002, Yoshinori Miyake, Noboru Teramoto, Kotaro Minato, Hidehiro Iida

    NeuroImage　47　(4)　1639-1648　2009

    DOI： 10.1016/j.neuroimage.2009.05.099 　

    ISSN： 1053-8119

  253. 高解像度定量ピンホールSPECTイメージング--小動物から臨床へ (特集 CT技術のブレイクスルー)

    銭谷 勉, 渡部 浩司, 工藤 博幸

    映像情報medical　40　(13)　1210-1215　2008/12

    Publisher: 産業開発機構

    ISSN： 1346-1354

  254. 神経画像法を用いた虚血性脳疾患の前臨床・臨床試験と病態把握

    林 拓也, 武信 洋平, 久冨 信之, 渡部 浩司, 寺本 昇, 佐藤 博司, 越野 一博, 岩西 雄大, 永沼 雅基, 森脇 博, 横田 千晶, 成富 博章, 峰松 一夫, 飯田 秀博

    循環器病研究の進歩　XXIX　(1)　79-86　2008/11

    Publisher: (株)協和企画

    ISSN： 0285-0710

  255. Optimal scan time of oxygen-15-labeled gas inhalation autoradiographic method for measurement of cerebral oxygen extraction fraction and cerebral oxygen metabolic rate Peer-reviewed

    Miho Shidahara, Hiroshi Watabe, Kyeong Min Kim, Nobuyuki Kudomi, Hiroshi Ito, Hidehiro Iida

    ANNALS OF NUCLEAR MEDICINE　22　(8)　667-675　2008/10

    DOI： 10.1007/s12149-008-0157-9 　

    ISSN： 0914-7187

  256. PETにおける散乱線および偶発同時計数による心筋血流の定量評価への影響

    平野 祥之, 飯田 秀博, 渡部 浩司, 石田 良雄, 木曽 啓祐

    核医学　45　(3)　S241-S241　2008/09

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  257. Three-dimensional SPECT reconstruction with transmission-dependent scatter correction Peer-reviewed

    Antti Sohlberg, Hiroshi Watabe, Hidehiro Iida

    ANNALS OF NUCLEAR MEDICINE　22　(7)　549-556　2008/08

    DOI： 10.1007/s12149-008-0170-z 　

    ISSN： 0914-7187

  258. Acceleration of Monte Carlo-based scatter compensation for cardiac SPECT Peer-reviewed

    A. Sohlberg, H. Watabe, H. Iida

    PHYSICS IN MEDICINE AND BIOLOGY　53　(14)　N277-N285　2008/07

    DOI： 10.1088/0031-9155/53/14/N02 　

    ISSN： 0031-9155

  259. Absolute quantitation of myocardial blood flow with Tl-201 and dynamic SPECT in canine: optimisation and validation of kinetic modelling Peer-reviewed

    Hidehiro Iida, Stefan Eberl, Kyeong-Min Kim, Yoshikazu Tamura, Yukihiko Ono, Mayumi Nakazawa, Antti Sohlberg, Tsutomu Zeniya, Takuya Hayashi, Hiroshi Watabe

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　35　(5)　896-905　2008/05

    DOI： 10.1007/s00259-007-0654-4 　

    ISSN： 1619-7070

    eISSN： 1619-7089

  260. SPECT の定量化と標準化

    渡部浩司

    Medical Imaging Technology　26　(1)　9-13　2008/01/25

    Publisher: 日本医用画像工学会

    DOI： 10.11409/mit.26.9 　

    ISSN： 0288-450X

  261. Combination of a high resolution detector with small fOV and a low resolution detector with large FOV for high resolution and quantitative SPECT Peer-reviewed

    Tsutomu Zeniya, Hiroshi Watabe, Hiroyuki Kudo, Yoshiyuki Hirano, Kotaro Minato, Hidehiro Iida

    IEEE Nuclear Science Symposium Conference Record　5229-5231　2008

    DOI： 10.1109/NSSMIC.2008.4774412 　

    ISSN： 1095-7863

  262. Clinical Usability of a Compact high resolution detector for high resolution and quantitative SPECT imaging in a selected small ROI Peer-reviewed

    Tsutomu Zeniya, Hiroshi Watabe, Hiroyuki Kudo, Yoshiyuki Hirano, Kotaro Minato, Hidehiro Iida

    IEEE Nuclear Science Symposium Conference Record　4257-4259　2008

    DOI： 10.1109/NSSMIC.2008.4774222 　

    ISSN： 1095-7863

  263. Quantitative Analysis of Donepezil Binding to Acetylcholinesterase Using Positron Emission Tomography and [5-11C-methoxy]Donepezil.

    Hiraoka K, Okamura N, Funaki Y, Watanuki S, Tashiro M, Kato M, Hayashi A, Hosokai Y, Yamasaki H, Fujii T, Mori E, Yanai K, Watabe H

    CYRIC Annual Report　2008　168-171　2008

    Publisher: Cyclotron and Radioisotope Center, Tohoku University

    More details Close

    CYRIC Annual Report 2008

  264. PET kinetic analysis: error consideration of quantitative analysis in dynamic studies Invited Peer-reviewed

    Yoko Ikoma, Hiroshi Watabe, Miho Shidahara, Mika Naganawa, Yuichi Kimura

    ANNALS OF NUCLEAR MEDICINE　22　(1)　1-11　2008/01

    DOI： 10.1007/s12149-007-0083-2 　

    ISSN： 0914-7187

  265. SPECT イメージング

    銭谷 勉, 渡部 浩司, 飯田 秀博

    遺伝子医学MOOK　2008

  266. 心筋 PET 検査の有用性

    越野 一博, 寺本 昇, 合瀬 恭幸, 福田 肇, 樋掛 正明, 渡部 浩司, 飯田 秀博

    臨床画像　2008

  267. 小動物用核医学装置の最近の進歩

    渡部浩司

    PET journal　2008

  268. Body-contour versus circular orbit acquisition in cardiac SPECT: Assessment of defect detectability with channelized Hotelling observer Peer-reviewed

    Antti Sohlberg, Hiroshi Watabe, Miho Shidahara, Hidehiro Lida

    NUCLEAR MEDICINE COMMUNICATIONS　28　(12)　937-942　2007/12

    DOI： 10.1097/MNM.0b013e3282f1b9a3 　

    ISSN： 0143-3636

  269. Accelerated 3D-OSEM image reconstruction using a Beowulf PC cluster for pinhole SPECT Peer-reviewed

    Tsutomu Zeniya, Hiroshi Watabe, Antti Sohlberg, Hidehiro Iida

    ANNALS OF NUCLEAR MEDICINE　21　(9)　537-543　2007/11

    DOI： 10.1007/s12149-007-0057-4 　

    ISSN： 0914-7187

    eISSN： 1864-6433

  270. 急性期脳血管障害の治療strategyにおける画像診断の役割 15Oガスを用いた迅速PET定量法

    飯田 秀博, 林 拓也, 渡部 浩司, 寺本 昇, 三宅 義徳, 永沼 雅基, 横田 千晶, 上原 敏志, 森脇 博, 武信 洋平, 成冨 博章, 峰松 一夫

    ブレイン・ファンクション・イメージング・カンファレンス記録集　(23)　17-20　2007/09

    Publisher: 日本メジフィジックス(株)

    ISSN： 1341-4984

  271. PET kinetic analysis: wavelet denoising of dynamic PET data with application to parametric imaging Invited Peer-reviewed

    Miho Shidahara, Yoko Ikoma, Jeff Kershaw, Yuichi Kimura, Mika Naganawa, Hiroshi Watabe

    ANNALS OF NUCLEAR MEDICINE　21　(7)　379-386　2007/09

    DOI： 10.1007/s12149-007-0044-9 　

    ISSN： 0914-7187

  272. Separation of input function for rapid measurement of quantitative CMRO2 and CBF in a single PET scan with a dual tracer administration method Peer-reviewed

    Nobuyuki Kudomi, Hiroshi Watabe, Takuya Hayashi, Hidehiro Iida

    PHYSICS IN MEDICINE AND BIOLOGY　52　(7)　1893-1908　2007/04

    DOI： 10.1088/0031-9155/52/7/009 　

    ISSN： 0031-9155

  273. PET and SPECT for small animal imaging

    Watabe, H., Teramoto, N., Ose, Y., Zeniya, T.

    Japanese Journal of Clinical Radiology　52　(9)　2007

    ISSN： 0009-9252

  274. Serial changes in hemodynamics in acute ischemic stroke: Clinical application of rapid dual autoradiographic method PET

    Ohara, T., Yokota, C., Hayashi, T., Naganuma, M., Kasuya, J., Uehara, T., Moriwaki, H., Toyoda, K., Watabe, H., Iida, H., Minematsu, K.

    Journal of Cerebral Blood Flow and Metabolism　27　(SUPPL. 1)　2007

    ISSN： 0271-678X

  275. Development of reference tissue method for multiple injections of [C-11]raclopride

    Watabe, H., Ohta, Y., Teramoto, N., Miyake, Y., Kurokawa, M., Yamamoto, A., Ose, Y., Ikoma, Y., Hayashi, T., Iida, H.

    Journal of Cerebral Blood Flow and Metabolism　27　(SUPPL. 1)　2007

    ISSN： 0271-678X

  276. Validity and value of quantitative spect reconstruction in a multi-center clinical study using I-123 radiopharmaceuticals

    Hidehiro, I., Hiroshi, W., Mayumi, N., Kohei, H.

    Journal of Cerebral Blood Flow and Metabolism　27　(SUPPL. 1)　BO03-09　2007

    ISSN： 0271-678X

  277. Absolute quantitation of regional cerebral blood flow in mouse using 123I-iodoamphetamine and pinhole SPECT

    Zeniya, T., Watabe, H., Ose, T., Hayashi, T., Teramoto, N., Myojin, K., Taguchi, A., Sato, H., Yamamoto, A., Sohlberg, A., Inomata, T., Iida, H.

    Journal of Cerebral Blood Flow and Metabolism　27　(SUPPL. 1)　2007

    ISSN： 0271-678X

  278. Acute embolic stroke model in cynomolgus monkeys using autologous blood clot

    Piao, R., Hayashi, T., Teramoto, N., Kudomi, N., Ohta, Y., Sato, H., Watabe, H., Iida, H.

    Journal of Cerebral Blood Flow and Metabolism　27　(SUPPL. 1)　2007

    ISSN： 0271-678X

  279. 3D-OSEM reconstruction from truncated data in pinhole SPECT Peer-reviewed

    Tsutomu Zeniya, Hiroshi Watabe, Antti Sohlberg, Toru Inomata, Hiroyuki Kudo, Hidehiro Iida

    IEEE Nuclear Science Symposium Conference Record　6　4205-4207　2007

    DOI： 10.1109/NSSMIC.2007.4437044 　

    ISSN： 1095-7863

  280. 3D-OSEM reconstruction from truncated data in pinhole SPECT Peer-reviewed

    Tsutomu Zeniya, Hiroshi Watabe, Antti Sohlberg, Toru Inomata, Hiroyuki Kudo, Hidehiro Iida

    2007 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-11　4205-4207　2007

    DOI： 10.1109/NSSMIC.2007.4437044 　

    ISSN： 1082-3654

  281. Blood flow analysis for Leukocytaphersis Column Peer-reviewed

    Hirokazu Onodera, Hiroshi Watabe, Kotaro Minato, Hidehiro Iida

    WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING 2006, VOL 14, PTS 1-6　14　2588-+　2007

    ISSN： 1680-0737

  282. PET kinetic analysis - Pitfalls and a solution for the Logan plot Invited Peer-reviewed

    Yuichi Kimura, Mika Naganawa, Miho Shidahara, Yoko Ikoma, Hiroshi Watabe

    ANNALS OF NUCLEAR MEDICINE　21　(1)　1-8　2007/01

    ISSN： 0914-7187

  283. Estimation of oxygen metabolism in a rat model of permanent ischemia using positron emission tomography with injectable O-15-O-2

    Takashi Temma, Yasuhiro Magata, Yuji Kuge, Sayaka Shimonaka, Kohei Sano, Yumiko Katada, Hidekazu Kawashima, Takahiro Mukai, Hiroshi Watabe, Hidehiro Iida, Hideo Saji

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　26　(12)　1577-1583　2006/12

    DOI： 10.1038/sj.jcbfm.9600302 　

    ISSN： 0271-678X

  284. Predicting human performance by channelized Hotelling observer in discriminating between Alzheimer's dementia and controls using statistically processed brain perfusion SPECT Peer-reviewed

    Miho Shidahara, Kentaro Inoue, Masahiro Maruyama, Hiroshi Watabe, Yasuyuki Taki, Ryoi Goto, Ken Okada, Shigeo Kinomura, Shinichiro Osawa, Yoshimi Onishi, Hiroshi Ito, Hiroyuki Arai, Hiroshi Fukuda

    ANNALS OF NUCLEAR MEDICINE　20　(9)　605-613　2006/11

    DOI： 10.1007/BF02984658 　

    ISSN： 0914-7187

  285. PET kinetic analysis - compartmental model Invited Peer-reviewed

    Hiroshi Watabe, Yoko Ikoma, Yuichi Kimura, Mika Naganawa, Miho Shidahara

    ANNALS OF NUCLEAR MEDICINE　20　(9)　583-588　2006/11

    DOI： 10.1007/BF02984655 　

    ISSN： 0914-7187

  286. Comparison of multi-ray and point-spread function based resolution recovery methods in pinhole SPECT reconstruction Peer-reviewed

    Antti Sohlberg, Hiroshi Watabe, Tsutomu Zeniya, Hidehiro Iida

    NUCLEAR MEDICINE COMMUNICATIONS　27　(10)　823-827　2006/10

    DOI： 10.1097/01.mnm.0000237993.83066.0b 　

    ISSN： 0143-3636

  287. Use of a compact pixellated gamma camera for small animal pinhole SPECT imaging Peer-reviewed

    Tsutomu Zeniya, Hiroshi Watabe, Toshiyuki Aoi, Kyeong Min Kim, Noboru Teramoto, Takeshi Takeno, Yoichiro Ohta, Takuya Hayashi, Hiroyuki Mashino, Toshihiro Ota, Seiichi Yamamoto, Hidehiro Iida

    ANNALS OF NUCLEAR MEDICINE　20　(6)　409-416　2006/07

    DOI： 10.1007/BF03027376 　

    ISSN： 0914-7187

  288. System design and development of a pinhole SPECT system for quantitative functional imaging of small animals Peer-reviewed

    T Aoi, T Zeniya, H Watabe, HM Deloar, T Matsuda, H Iida

    ANNALS OF NUCLEAR MEDICINE　20　(3)　245-251　2006/04

    DOI： 10.1007/BF03027438 　

    ISSN： 0914-7187

  289. Performance of list mode data acquisition with ECAT EXACT HR and ECAT EXACT HR+ positron emission scanners Peer-reviewed

    H Watabe, K Matsumoto, M Senda, H Iida

    ANNALS OF NUCLEAR MEDICINE　20　(3)　189-194　2006/04

    DOI： 10.1007/BF03027429 　

    ISSN： 0914-7187

  290. Validity and value of multi-center clinical evaluation using quantitative SPECT reconstruction package (QSPECT) for I-123 radiopharmaceuticals Peer-reviewed

    M. Nakazawa, H. Watabe, T. Akamatsu, K. -M. Kim, Hidehiro Iida

    NEUROIMAGE　31　T174-T174　2006

    DOI： 10.1016/j.neuroimage.2006.04.157 　

    ISSN： 1053-8119

  291. Body-Contour Acquisition Versus Circular Orbit Acquisition with Resolution Recovery in Cardiac SPECT Peer-reviewed

    Antti Sohlberg, Hiroshi Watabe, Hidehiro Iida

    2006 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOL 1-6　3258-3261　2006

    ISSN： 1082-3654

  292. Effect of Truncation in Quantitative Cardiac Imaging with Small Field-of-View Pinhole SPECT Peer-reviewed

    Tsutomu Zeniya, Hiroshi Watabe, Antti Sohlberg, Toru Inomata, Hiroyuki Kudo, Hidehiro Iida

    2006 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOL 1-6　3239-3241　2006

    ISSN： 1082-3654

  293. Intra-striatal representation of cortical connection in human and macaque Peer-reviewed

    Takuya Hayashi, Hiroshi Sato, Shinichi Abe, Takashi Hanakawa, Hiroshi Watabe, Hidenao Fukuyama, Babak Aldekani, Hidehiro Iida

    NEUROSCIENCE RESEARCH　55　S260-S260　2006

    ISSN： 0168-0102

  294. Use of reference tissue models for quantification of histamine H-1 receptors in human brain by using positron emission tomography and [C-11]doxepin

    Atsuro Suzuki, Keizo Ishii, Manabu Tashiro, Yuichi Kimura, Kenji Ishii, Kiichi Ishiwata, Hideki Mochizuki, Kazuhiko Yanai, Hiroshi Watabe

    FUTURE MEDICAL ENGINEERING BASED ON BIONANOTECHNOLOGY, PROCEEDINGS　817-+　2006

  295. Quantitative mapping of basal and vasareactive cerebral blood flow using split-dose 123I-iodoamphetamine and single photon emission computed tomography. Peer-reviewed

    Kyeong-Min Kim, Hiroshi Watabe, Takuya Hayashi 0002, Kohei Hayashida, Tetsuro Katafuchi, Naoyuki Enomoto, Toshiyuki Ogura, Miho Shidahara, Shugo Takikawa, Stefan Eberl, Mayumi Nakazawa, Hidehiro Iida

    NeuroImage　33　(4)　1126-1135　2006

    DOI： 10.1016/j.neuroimage.2006.06.064 　

    ISSN： 1053-8119

  296. Development of a practical image-based scatter correction method for brain perfusion SPECT: comparison with the TEW method Peer-reviewed

    M Shidahara, H Watabe, KM Kim, T Kato, S Kawatsu, R Kato, K Yoshimura, H Iida, K Ito

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　32　(10)　1193-1198　2005/10

    DOI： 10.1007/s00259-005-1791-2 　

    ISSN： 1619-7070

  297. Use of reference tissue models for quantification of histamine H-1 receptors in human brain by using positron emission tomography and [C-11]doxepin Peer-reviewed

    A Suzuki, M Tashiro, Y Kimura, H Mochizuki, K Ishii, H Watabe, K Yanai, K Ishiwata, K Ishii

    ANNALS OF NUCLEAR MEDICINE　19　(6)　425-433　2005/09

    ISSN： 0914-7187

  298. Rapid quantitative measurement of CMRO2 and GBF by dual administration of O-15-labeled oxygen and water during a single PET scan - a validation study and error analysis in anesthetized monkeys Peer-reviewed

    N Kudomi, T Hayashi, N Teramoto, H Watabe, N Kawachi, Y Ohta, KM Kim, H Iida

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　25　(9)　1209-1224　2005/09

    DOI： 10.1038/sj.jcbfm.9600118 　

    ISSN： 0271-678X

  299. Understanding of cerebral energy metabolism by dynamic living brain slice imaging system with [(18)F]FDG Peer-reviewed

    M Ogawa, H Watabe, N Teramoto, Y Miyake, T Hayashi, H Iida, T Murata, Y Magata

    NEUROSCIENCE RESEARCH　52　(4)　357-361　2005/08

    DOI： 10.1016/j.neures.2005.04.007 　

    ISSN： 0168-0102

  300. Parametric imaging of myocardial blood flow with O-15-water and PET using the basis function method Peer-reviewed

    H Watabe, H Jino, N Kawachi, N Teramoto, T Hayashi, Y Ohta, H Iida

    JOURNAL OF NUCLEAR MEDICINE　46　(7)　1219-1224　2005/07

    ISSN： 0161-5505

  301. Performance of evaluation of a new image acquisition strategy in pinhole SPECT: A simulation study Peer-reviewed

    Tsutomu Zeniya, Hiroshi Watabe, Toshiyuki Aoi, Atsuko Kubo, Hidehiro Iida

    IEEE Nuclear Science Symposium Conference Record　3　1774-1776　2005

    DOI： 10.1109/NSSMIC.2005.1596664 　

    ISSN： 1095-7863

  302. Development of fully automatic technique to generate parametric images of myocardial blood flow with15O-water and positron emission tomography using basis function method Peer-reviewed

    Hiroshi Watabe, Kazuhiro Koshino, Noboru Teramoto, Youichiro Ohta, Takuya Hayashi, Hidehiro Iida

    IEEE Nuclear Science Symposium Conference Record　4　2256-2258　2005

    DOI： 10.1109/NSSMIC.2005.1596784 　

    ISSN： 1095-7863

  303. Development of fully automatic technique to generate parametric images of myocardial blood flow with O-15-water and positron emission tomography using basis function method Peer-reviewed

    Hiroshi Watabe, Kazuhiro Koshino, Noboru Teramoto, Youichiro Ohta, Takuya Hayashi, Hidehiro Iida

    2005 IEEE Nuclear Science Symposium Conference Record, Vols 1-5　2256-2258　2005

    ISSN： 1082-3654

  304. Performance of evaluation of a new image acquisition strategy in pinhole SPECT: a simulation study Peer-reviewed

    Tsutomu Zeniya, Hiroshi Watabe, Toshiyuki Aoi, Atsuko Kubo, Hidehiro Iida

    2005 IEEE Nuclear Science Symposium Conference Record, Vols 1-5　1774-1776　2005

    DOI： 10.1109/NSSMIC.2005.1596664 　

    ISSN： 1082-3654

  305. Cerebral decreases in opioid receptor binding in patients with central neuropathic pain measured by [C-11]diprenorphine binding and PET Peer-reviewed

    AKP Jones, H Watabe, VJ Cunningham, T Jones

    EUROPEAN JOURNAL OF PAIN　8　(5)　479-485　2004/10

    DOI： 10.1016/j.ejpain.2003.11.017 　

    ISSN： 1090-3801

  306. Image improvement in pinhole SPECT using complete data acquisition combined with statistical image reconstruction Peer-reviewed

    Tsutomu Zeniya, Hiroshi Watabe, Toshiyuki Aoi, Kyeong Min Kim, Noboru Teramoto, Takuya Hayashi, Antti Sohlberg, Hiroyuki Kudo, Hidehiro Iida

    International Congress Series　1265　(C)　101-105　2004/08/01

    DOI： 10.1016/j.ics.2004.04.026 　

    ISSN： 0531-5131

  307. Dynamic spectroscopy of hyperpolarized Xe-129 in rat lung Peer-reviewed

    Hiroshi Sato, Jun-ichiro Enmi, Takuya Hayashi, Naoyuki Takei, Yuji Iwadate, Sumiko Abe, Noboru Teramoto, Naoki Kawachi, Mineyuki Hattori, Hiroshi Watabe, Tohru Sawada, Katsumi Uchiyama, Tetsuji Tsukamoto, Kiyoshi Nagasawa, Hidehiro Iida

    International Congress Series　1265　(C)　131-138　2004/08/01

    DOI： 10.1016/j.ics.2004.04.017 　

    ISSN： 0531-5131

  308. Rapid protocol for quantitative CMRO2 and CBF using PET and O-15 labelled compounds Peer-reviewed

    Kudomi Nobuyuki, Hayashi Takuya, Teramoto Noboru, Watabe Hiroshi, Kawachi Naoki, Ohta Youichirou, Kim KyonMim, Iida Hidehiro

    International Congress Series　1265　(C)　60-68　2004/08/01

    DOI： 10.1016/j.ics.2004.04.042 　

    ISSN： 0531-5131

  309. Measurement of cerebral blood flow with dynamic susceptibility contrast MRI and comparison with O-15 positron emission tomography Peer-reviewed

    Jun-ichiro Enmi, Takuya Hayashi, Hiroshi Watabe, Hiroshi Moriwaki, Naoaki Yamada, Hidehiro Iida

    International Congress Series　1265　(C)　150-158　2004/08/01

    DOI： 10.1016/j.ics.2004.04.045 　

    ISSN： 0531-5131

  310. A new reconstruction strategy for image improvement in pinhole SPECT Peer-reviewed

    T Zeniya, H Watabe, T Aoi, KM Kim, N Teramoto, T Hayashi, A Sohlberg, H Kudo, H Iida

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　31　(8)　1166-1172　2004/08

    DOI： 10.1007/s00259-004-1510-4 　

    ISSN： 1619-7070

  311. Long-term effect of motor cortical repetitive transcranial magnetic stimulation induces Peer-reviewed

    T Hayashi, T Ohnishi, S Okabe, N Teramoto, Y Nonaka, H Watabe, E Imabayashi, Y Ohta, H Jino, N Ejima, T Sawada, H Iida, H Matsuda, Y Ugawa

    ANNALS OF NEUROLOGY　56　(1)　77-85　2004/07

    DOI： 10.1002/ana.20151 　

    ISSN： 0364-5134

  312. (18)F-FDG accumulation in atherosclerotic plaques: Immunohistochemical and PET imaging study Peer-reviewed

    M Ogawa, S Ishino, T Mukai, D Asano, N Teramoto, H Watabe, N Kudomi, M Shiomi, Y Magata, H Iida, H Saji

    JOURNAL OF NUCLEAR MEDICINE　45　(7)　1245-1250　2004/07

    ISSN： 0161-5505

  313. Sinogram-based motion correction of PET images using optical motion tracking system and list-mode data acquisition Peer-reviewed

    Sang-Keun Woo, Hiroshi Watabe, Yong Choi, Kyeong Min Kim, Chang Choon Park, Peter M. Bloomfield, Hidehiro Iida

    IEEE Transactions on Nuclear Science　51　(3)　782-788　2004/06

    DOI： 10.1109/TNS.2004.829786 　

    ISSN： 0018-9499

  314. Optimization of the width of the photopeak energy window in the TDCS technique for scatter correction in quantitative SPECT Peer-reviewed

    HM Deloar, H Watabe, KM Kim, T Aoi, E Kunieda, H Fujii, H Iida

    IEEE TRANSACTIONS ON NUCLEAR SCIENCE　51　(3)　625-630　2004/06

    DOI： 10.1109/TNS.2004.829752 　

    ISSN： 0018-9499

  315. Future perspectives in in vivo quantitation of bio-physiological parameters Peer-reviewed

    H. Iida, H. Watabe, T. Hayashi, N. Kudomi, K. M. Kim, T. Zeniya, N. Teramoto, Y. Ohta

    International Congress Series　1264　(C)　148-157　2004/03/01

    DOI： 10.1016/j.ics.2004.01.001 　

    ISSN： 0531-5131

  316. Endogenous dopamine release induced by repetitive transcranial magnetic stimulation over the primary motor cortex: An [11C]raclopride positron emission tomography study in anesthetized macaque monkeys Peer-reviewed

    Takashi Ohnishi, Takuya Hayashi, Shingo Okabe, Ikuo Nonaka, Hiroshi Matsuda, Hidehiro Iida, Etsuko Imabayashi, Hiroshi Watabe, Yoshihiro Miyake, Mikako Ogawa, Noboru Teramoto, Yoichirou Ohta, Norimasa Ejima, Tohru Sawada, Yoshikazu Ugawa

    Biological Psychiatry　55　(5)　484-489　2004/03/01

    DOI： 10.1016/j.biopsych.2003.09.016 　

    ISSN： 0006-3223

  317. Statistical error analysis based on non-parametric bootstrap method of quantitative MBF measurement with H2 15O_PET

    Naoki Kawachi, Hiroshi Watabe, Noboru Teramoto, Yoichiro Ohta, Hiroshi Jino, Nobuyuki Kudimo, Kazuyuki Koshino, Kyeong Min Kim, Takuya Hayashi, Hidehiro Iida

    IEEE Nuclear Science Symposium Conference Record　4　2660-2663　2004

    ISSN： 1095-7863

  318. Therapeutic mechanism of repetitive transcranial magnetic stimulation (rTMS)—a monkey PET study Peer-reviewed

    Takuya Hayashi, Noboru Teramoto, Hiroshi Watabe, Yohichiro Ohta, Hiroshi Jino, Hidehiro Iida, Takashi Ohnishi, Etsuko Imabayashi, Hiroshi Matsuda, Shingo Okabe, Yoshikazu Ugawa, Yukio Nonaka, Norimasa Ejima, Tohru Sawada

    International Congress Series　1264　(C)　186-190　2004

    DOI： 10.1016/j.ics.2003.12.065 　

    ISSN： 0531-5131

  319. Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2 receptors using [ 123I]epidepride SPET Peer-reviewed

    Masahiro Fujita, Andrea Varrone, Kyeong Min Kim, Hiroshi Watabe, Sami S. Zoghbi, Nicholas Seneca, Dnyanesh Tipre, John P. Seibyl, Robert B. Innis, Hidehiro Iida

    European Journal of Nuclear Medicine and Molecular Imaging　31　(5)　644-654　2004

    Publisher: Springer Verlag

    DOI： 10.1007/s00259-003-1431-7 　

    ISSN： 1619-7070

  320. 3D image reconstruction using complete data in pinhole SPECT Peer-reviewed

    T Zeniya, H Watabe, T Aoi, KM Kim, N Teramoto, T Hayashi, A Sohlberg, H Kudo, H Iida

    2003 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-5　2100-2102　2004

    ISSN： 1082-3654

  321. A physiological model for cerebral oxygen delivery and consumption and effective oxygen diffusibility evaluated by PET Peer-reviewed

    T Hayashi, N Kudomi, N Teramoto, H Watabe, JI Enmi, KM Kim, H Iida

    QUANTITATION IN BIOMEDICAL IMAGING WITH PET AND MRI　(1265)　228-237　2004

    DOI： 10.1016/j.ics.2004.04.043 　

    ISSN： 0531-5131

  322. Extraction of blood pool in dynamic O-15 water PET with slow-infusion using factor analysis Peer-reviewed

    KM Kim, H Watabe, N Kawachi, H Iida

    2003 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-5　2640-2641　2004

    ISSN： 1082-3654

  323. Parametric mapping of blood flow and arterial blood volume in dynamic O-15 water brain PET by cluster analysis Peer-reviewed

    KM Kim, H Watabe, N Kudomi, T Hayashi, K Hayashida, H Iida

    2003 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-5　3108-3109　2004

    ISSN： 1082-3654

  324. Performance improvement of event-based motion correction for PET using a PC cluster Peer-reviewed

    H Watabe, SK Woo, KM Kim, N Kudomi, H Iida

    2003 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-5　2407-2409　2004

    ISSN： 1082-3654

  325. Adenosine-induced myocardial flow reactivity in pig as assessed with O-15 water PET Peer-reviewed

    H Jino, N Kawachi, N Teramoto, Y Ohta, N Kudomi, T Hayashi, H Watabe, IU Yokoyama, H Iida

    PET AND MOLECULAR IMAGING: STATE OF THE ART AND FUTURE PERSPECTIVES　1264　117-125　2004

    DOI： 10.1016/j.ics.2004.01.080 　

    ISSN： 0531-5131

  326. Imaging of vulnerable atherosclerotic plaque with [(18)F]FDG-PET: an animal atherosclerosis model study Peer-reviewed

    M Ogawa, T Mukai, S Ishino, N Teramoto, H Watabe, N Kudomi, M Shiomi, Y Magata, H Iida, H Saji

    QUANTITATION IN BIOMEDICAL IMAGING WITH PET AND MRI　(1265)　266-268　2004

    DOI： 10.1016/j.ics.2004.02.167 　

    ISSN： 0531-5131

  327. Improved parametric images of blood flow and vascular volume by cluster analysis in (H2O)-O-15 brain PET study Peer-reviewed

    KM Kim, H Watabe, T Hayashi, H Iida

    QUANTITATION IN BIOMEDICAL IMAGING WITH PET AND MRI　(1265)　79-83　2004

    DOI： 10.1016/j.ics.2004.05.076 　

    ISSN： 0531-5131

  328. Statistical error analysis based on non-parametric bootstrap method of quantitative MBF measurement with (H2O)-O-15_PET Peer-reviewed

    N Kawachi, H Watabe, N Teramoto, Y Ohta, H Jino, N Kudimo, K Koshino, KM Kim, T Hayashi, H Iida

    2004 IEEE Nuclear Science Symposium Conference Record, Vols 1-7　2660-2663　2004

    ISSN： 1082-3654

  329. Effects of motion correction on quantification of myocardial blood flow with O-15-H2O PET Peer-reviewed

    K Koshino, N Kawachi, T Hayashi, H Watabe, S Hasegawa, J Hatazawa, H Iida

    QUANTITATION IN BIOMEDICAL IMAGING WITH PET AND MRI　(1265)　106-110　2004

    DOI： 10.1016/j.ics.2004.04.41 　

    ISSN： 0531-5131

  330. Development of image-based scatter correction for brain perfusion SPECT study: Comparison with TEW method Peer-reviewed

    M Shidahara, H Watabe, KM Kim, S Kawatsu, T Kato, H Iida

    2003 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-5　2652-2656　2004

    ISSN： 1082-3654

  331. Impact of image-based scatter correction for (IMP)-I-123-SPECT and SPM analysis Peer-reviewed

    M Shidahara, H Watabe, KM Kim, S Kawatsu, R Kato, T Kato, H Iida, K Ito

    QUANTITATION IN BIOMEDICAL IMAGING WITH PET AND MRI　(1265)　84-88　2004

    DOI： 10.1016/j.ics.2004.04.027 　

    ISSN： 0531-5131

  332. Development of motion correction technique for PET study using optical tracking system Peer-reviewed

    H Watabe, K Koshino, PM Bloomfield, RR Fulton, H Iida

    QUANTITATION IN BIOMEDICAL IMAGING WITH PET AND MRI　(1265)　31-38　2004

    DOI： 10.1016/j.ics.2004.04.013 　

    ISSN： 0531-5131

  333. Development of a hyperpolarized 129Xe System on 3T for the rat lungs Peer-reviewed

    Hiroshi Sato, Jun-Ichiro Enmi, Takuya Hayashi, Naoyuki Takei, Yuji Iwadate, Sumiko Abe, Noboru Teramoto, Naoki Kawachi, Mineyuki Hattori, Hiroshi Watabe, Tohru Sawada, Katsumi Uchiyama, Tetsuji Tsukamoto, Kiyoshi Nagasawa, Hidehiro Iida

    Magnetic Resonance in Medical Sciences　3　(1)　1-9　2004

    Publisher: 1

    DOI： 10.2463/mrms.3.1 　

    ISSN： 1347-3182 1880-2206

  334. Development of Method to Estimate Delay Time for Arterial Imput Function with [ 15O]CO 2-PET Study Using Sinogram Data and Attenuation Map Peer-reviewed

    Hiroshi Watabe, Keiichi Matsumoto, Setsu Sakamoto, Michio Senda, Hidehiro Iida

    Kakuigaku　41　(1)　17-23　2004

    ISSN： 0022-7854

  335. A theoretical model of oxygen delivery and metabolism for physiologic interpretation of quantitative cerebral blood flow and metabolic rate of oxygen Peer-reviewed

    T Hayashi, H Watabe, N Kudomi, KM Kim, JI Enmi, T Hayashida, H Iida

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　23　(11)　1314-1323　2003/11

    DOI： 10.1097/01.WCB.0000090506.76664.00 　

    ISSN： 0271-678X

  336. Activation of the anterior cingulate gyrus by 'green odor': A positron emission tomography study in the monkey Peer-reviewed

    Tetsuya Sasabe, Masayuki Kobayashi, Yusuke Kondo, Hirotaka Onoe, So Matsubara, Shigeyuki Yamamoto, Hideo Tsukada, Kayo Onoe, Hiroshi Watabe, Hidehiro Iida, Mikihiko Kogo, Kohta Sano, Akikazu Hatanaka, Tohru Sawada, Yasuyoshi Watanabe

    Chemical Senses　28　(7)　565-572　2003/09

    DOI： 10.1093/chemse/bjg048 　

    ISSN： 0379-864X

  337. Accelerated median root prior reconstruction for pinhole single-photon emission tomography (SPET) Peer-reviewed

    A Sohlberg, U Ruotsalainen, H Watabe, H Iida, JT Kuikka

    PHYSICS IN MEDICINE AND BIOLOGY　48　(13)　1957-1969　2003/07

    DOI： 10.1088/0031-9155/48/13/308 　

    ISSN： 0031-9155

  338. Evaluation of penetration and scattering components in conventional pinhole SPECT: phantom studies using Monte Carlo simulation Peer-reviewed

    HM Deloar, H Watabe, T Aoi, H Iida

    PHYSICS IN MEDICINE AND BIOLOGY　48　(8)　995-1008　2003/04

    DOI： 10.1088/0031-9155/48/8/303 　

    ISSN： 0031-9155

  339. Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities Peer-reviewed

    KM Kim, A Varrone, H Watabe, M Shidahara, M Fujita, RB Innis, H Iida

    JOURNAL OF NUCLEAR MEDICINE　44　(4)　512-519　2003/04

    ISSN： 0161-5505

  340. Dependency of energy and spatial distributions of photons on edge of object in brain SPECT Peer-reviewed

    HM Deloar, H Watabe, N Kudomi, KM Kim, T Aoi, H Iida

    ANNALS OF NUCLEAR MEDICINE　17　(2)　99-106　2003/04

    ISSN： 0914-7187

  341. Development of a GSO detector assembly for a continuous blood sampling system Peer-reviewed

    N Kudomi, E Choi, S Yamamoto, H Watabe, KM Kim, M Shidahara, M Ogawa, N Teramoto, E Sakamoto, H Iida

    IEEE TRANSACTIONS ON NUCLEAR SCIENCE　50　(1)　70-73　2003/02

    DOI： 10.1109/TNS.2002.807869 　

    ISSN： 0018-9499

  342. Motion estimation and correction for myocardial perfusion imaging

    Li-Yueh Hsu, Kang-Ping Lin, Yu-Chang Hu, Naoaki Yamada, Hiroshi Watabe, Hidehiro Lida

    IFAC Proceedings Volumes (IFAC-PapersOnline)　36　(15)　157-161　2003

    Publisher: IFAC Secretariat

    DOI： 10.1016/S1474-6670(17)33492-4 　

    ISSN： 1474-6670

  343. Model-based background compensation for repeat PET study with multiple tracer administration

    Hidehiro Iida, Hiroshi Watabe, Takuya Hayashi, Nobuyuki Kudomi, Keyong-Min Kim

    IFAC Proceedings Volumes (IFAC-PapersOnline)　36　(15)　29-34　2003

    Publisher: IFAC Secretariat

    DOI： 10.1016/S1474-6670(17)33467-5 　

    ISSN： 1474-6670

  344. Parametric mapping of blood flow and arterial blood volume in dynamic O-15 water brain PET by cluster analysis

    Kyeong Min Kim, Hiroshi Watabe, Nobuyuki Kudomi, Takuya Hayashi, Kohei Hayashida, Hidehiro Iida

    IEEE Nuclear Science Symposium Conference Record　5　3108-3109　2003

    ISSN： 1095-7863

  345. 3D image reconstruction using complete data in pinhole SPECT

    T. Zeniya, H. Watabe, T. Aoi, K. M. Kim, N. Teramoto, T. Hayashi, A. Sohlberg, H. Kudo, H. Iida

    IEEE Nuclear Science Symposium Conference Record　3　2100-2102　2003

    Publisher: Institute of Electrical and Electronics Engineers Inc.

    DOI： 10.1109/nssmic.2003.1352294 　

    ISSN： 1095-7863

  346. Extraction of blood pool in dynamic O-15 water PET with slow-infusion using factor analysis

    Kyeong Min Kim, Hiroshi Watabe, Naoki Kawachi, Hidehiro Iida

    IEEE Nuclear Science Symposium Conference Record　4　2640-2641　2003

    ISSN： 1095-7863

  347. Development of image-based scatter correction for brain perfusion SPECT study: Comparison with TEW method

    Miho Shidahara, Hiroshi Watabe, KyeongMin Kim, Shoji Kawatsu, Takashi Kato, Hidehiro Iida, Kengo Ito

    IEEE Nuclear Science Symposium Conference Record　4　2652-2656　2003

    ISSN： 1095-7863

  348. Chapter 8 A coil for magnetic stimulation of the macaque monkey brain Peer-reviewed

    Yukio Nonaka, Takuya Hayashi, Takashi Ohnishi, Shingo Okabe, Noboru Teramoto, Shoogo Ueno, Hiroshi Watabe, Hiroshi Matsuda, Hidehiro Iida, Yoshikazu Ugawa

    Supplements to Clinical Neurophysiology　56　(C)　75-80　2003

    DOI： 10.1016/S1567-424X(09)70211-9 　

    ISSN： 1567-424X

  349. Development of event-based motion correction technique for PET study using list-mode acquisition and optical motion tracking system. Peer-reviewed

    Sang-Keun Woo, Hiroshi Watabe, Yong Choi, Kyeong-Min Kim, Chang Choon Park, Roger R. Fulton, Peter M. Bloomfield, Hidehiro Iida

    Proceedings of SPIE - The International Society for Optical Engineering　5032　1300-1307　2003

    Publisher: SPIE

    DOI： 10.1117/12.481356 　

    ISSN： 0277-786X

  350. Model-based background compensation for repeat PET study with multiple tracer administration Peer-reviewed

    H Iida, H Watabe, T Hayashi, N Kudomi, KM Kim

    MODELLING AND CONTROL IN BIOMEDICAL SYSTEMS 2003 (INCLUDING BIOLOGICAL SYSTEMS)　29-34　2003

    ISSN： 0962-9505

  351. Evaluation of energy dependency of TDCS method for scattering correction in quantitative SPECT Peer-reviewed

    HM Deloar, H Watabe, KM Kim, T Aoi, H Iida

    2002 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-3　1802-1805　2003

    ISSN： 1082-3654

  352. Absolute quantitation of regional myocardial blood flow of rats using dynamic pinhole SPECT Peer-reviewed

    T Aoi, H Watabe, HM Deloar, M Ogawa, N Teramoto, N Kudomi, T Oota, KM Kim, T Matsuda, H Iida

    2002 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-3　1780-1783　2003

    ISSN： 1082-3654

  353. Simulation study of noise property of CMRO2 quantitation methods with inhalation of O-15(2) Peer-reviewed

    N Kudomi, H Watabe, Y Miyake, KM Kim, M Shidahara, K Hayashida, H Oka, M Sagou, Y Ishida, T Hayashi, H Iida

    2002 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-3　1116-1117　2003

    ISSN： 1082-3654

  354. Performance test and application of GSO detector assembly for a continuous blood sampling system Peer-reviewed

    N Kudomi, E Choi, S Yamamoto, H Watabe, KM Kim, T Hayashi, M Ogawa, N Teramoto, E Sakamoto, H Iida

    2002 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-3　1648-1651　2003

    ISSN： 1082-3654

  355. Model-based noninvasive estimation of arterial input function from dynamic (H2OPET)-O-15 images Peer-reviewed

    N Kudomi, H Watabe, KM Kim, T Hayashi, K Hayashida, H Iida

    2002 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-3　1559-1561　2003

    ISSN： 1082-3654

  356. Sinogram-based motion correction of PET images using optical motion tracking system and list-mode data acquisition Peer-reviewed

    SK Woo, H Watabe, Y Choi, KM Kim, CC Park, H Iida

    2002 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-3　830-834　2003

    ISSN： 1082-3654

  357. Estimation of input function for rapid dual table ARG method Peer-reviewed

    N Kudomi, H Watabe, KN Kim, K Hayashida, T Hayashi, H Iida

    2002 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-3　1339-1340　2003

    ISSN： 1082-3654

  358. Performance of list-mode data acquisition with ECAT EXACT HR positron emission scanner Peer-reviewed

    H Watabe, SK Woo, KM Ki, H Matsuura, K Matsumoto, PM Bloomfield, H Iida

    2002 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-3　970-973　2003

    ISSN： 1082-3654

  359. Evaluation of a commercial PET tomograph-based system for the quantitative assessment of rCBF, rOEF and rCMRO(2) by using sequential administration of O-15-labeled compounds Peer-reviewed

    M Shidahara, H Watabe, KM Kim, H Oka, M Sago, T Hayashi, Y Miyake, Y Ishida, K Hayashida, T Nakamura, H Iida

    ANNALS OF NUCLEAR MEDICINE　16　(5)　317-327　2002/07

    ISSN： 0914-7187

  360. Impact of attenuation and scatter correction in SPECT for quantification of cerebral blood flow using 99mTc-ethyl cysteinate dimer Peer-reviewed

    Miho Shidahara, Hiroshi Watabe, Kyeong Min Kim, Takenori Hachiya, Ichiro Sayama, Iwao Kanno, Takashi Nakamura, Hidehiro Iida

    IEEE Transactions on Nuclear Science　49　(1 I)　5-11　2002/02

    DOI： 10.1109/TNS.2002.998673 　

    ISSN： 0018-9499

  361. Evaluation of Two Scatter Correction Methods in Quantitative Brain SPECT with Dopaminergic Tracer

    Kyeong Min Kim, Hiroshi Watabe, Andrea Varrone, Masahiro Fujita, Robert B. Innis, Hidehiro Iida

    IEEE Nuclear Science Symposium and Medical Imaging Conference　3　1792-1796　2002

  362. Multi-phase 3D MR tagging method based on TrueFISP sequence Peer-reviewed

    Shin-Ichi Urayama, Leon Axel, Naoaki Yamada, Jun Okamoto, Hiroshi Watabe, Hidehiro Iida

    Proceedings of SPIE - The International Society for Optical Engineering　4683　130-138　2002

    DOI： 10.1117/12.463575 　

    ISSN： 0277-786X

  363. A Stochastic typhoon simulation model and the possibility of its application to the insurance industry in Asia Peer-reviewed

    H Watabe, M Matsumoto

    PROCEEDINGS OF THE SECOND INTERNATIONAL SYMPOSIUM ON ADVANCES IN WIND & STRUCTURES (AWAS'02)　315-322　2002

  364. Impact of scatter correction in the kinetic analysis of a D2 receptor ligand SPECT study Peer-reviewed

    KM Kim, H Watabe, M Shidahara, Y Onishi, Y Yonekura, H Iida

    2001 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORDS, VOLS 1-4　1509-1512　2002

    ISSN： 1082-3654

  365. Noninvasive estimation of cerebral blood flow using image-derived carotid input function in (H2O)-O-15 dynamic PET Peer-reviewed

    KM Kim, H Watabe, M Shidahara, JY Ahn, S Choi, N Kudomi, K Hayashida, Y Miyake, H Iida

    2001 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORDS, VOLS 1-4　1282-1285　2002

    ISSN： 1082-3654

  366. Acquisition of attenuation map for brain PET study using optical tracking system Peer-reviewed

    H Watabe, N Sato, HM Deloar, S Urayama, H Oka, H Iida

    2001 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORDS, VOLS 1-4　1458-1461　2002

    ISSN： 1082-3654

  367. Development of a GSO detector assembly for a continuous blood sampling system Peer-reviewed

    N Kudomi, E Choi, S Yamamoto, H Watabe, KM Kim, M Shidahara, H Iida

    2001 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORDS, VOLS 1-4　1255-1257　2002

    ISSN： 1082-3654

  368. Development of a phoswich detector for a continuous blood-sampling system Peer-reviewed

    S. Yamamoto, K. Tarutani, M. Suga, K. Minato, H. Watabe, H. Iida

    IEEE Transactions on Nuclear Science　48　(4)　1408-1411　2001/08

    DOI： 10.1109/23.958367 　

    ISSN： 0018-9499

  369. SPECT collimator dependency of scatter and validation of transmission-dependent scatter compensation methodologies Peer-reviewed

    Kyeong Min Kim, H. Watabe, M. Shidahara, Y. Ishida, H. Iida

    IEEE Transactions on Nuclear Science　48　(3)　689-696　2001/06

    DOI： 10.1109/23.940148 　

    ISSN： 0018-9499

  370. Noninvasive Estimation of the Aorta Input Function for Measurement of Tumor Blood Flow with [15O] Water.

    Hiroshi Watabe, Michael A. Channing, Cyril Riddell, Frederic Jousse, Stephen K. Libutti, Jorge A. Carrasquillo, Stephen L. Bacharach, Richard E. Carson

    IEEE Trans. Medical Imaging　20　(3)　164-174　2001

    DOI： 10.1109/42.918468 　

  371. PET evaluation of [F-18]FCWAY, an analog of the 5-HT1A receptor antagonist, WAY-100635 Peer-reviewed

    RE Carson, LX Lan, H Watabe, MG Der, HR Adams, E Jagoda, P Herscovitch, WC Eckelman

    NUCLEAR MEDICINE AND BIOLOGY　27　(5)　493-497　2000/07

    DOI： 10.1016/S0969-8051(00)00118-9 　

    ISSN： 0969-8051

  372. Kinetic analysis of the 5-HT(2A) ligand [(11)C]MDL 100,907 Peer-reviewed

    H Watabe, MA Channing, MG Der, HR Adams, E Jagoda, P Herscovitch, WC Eckelman, RE Carson

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　20　(6)　899-909　2000/06

    DOI： 10.1097/00004647-200006000-00002 　

    ISSN： 0271-678X

  373. Measurement of dopamine release with continuous infusion of [C-11]raclopride: Optimization and signal-to-noise considerations Peer-reviewed

    H Watabe, CJ Endres, A Breier, B Schmall, WC Eckelman, RE Carson

    JOURNAL OF NUCLEAR MEDICINE　41　(3)　522-530　2000/03

    ISSN： 0161-5505

  374. Consideration of backscatter photons for edge detection in SPECT

    H. Watabe, M. Shidahara, K. M. Kim, H. Iida

    IEEE Nuclear Science Symposium and Medical Imaging Conference　2　13/147　2000

  375. Modeling strategy for background compensation in repeat cerebral blood flow quantitation with diffusible tracers

    H. Iida, H. Watabe, M. Shidahara, K. Min Kim, S. Takikawa, T. Ogura, K. Hayashida, Y. Ishida

    IEEE Nuclear Science Symposium and Medical Imaging Conference　3　18/39　2000

  376. The reference tissue model : Three compartments for the reference region

    H. Watabe, R. E. Carson, H. Iida

    NeuroImage　11　(6)　S12　2000

    ISSN： 1053-8119

  377. SPM:SPM99 と脳核医学

    渡部浩司

    映像情報Medical　32　(24)　1402-1406　2000

    Publisher:

    ISSN： 0389-214X

  378. Receptor Activation Model

    渡部浩司

    ＰＥＴ通信　1999

  379. Estimation of absorbed dose for 2-[F-18]fluoro-2-deoxy-D-glucose using whole-body positron emission tomography and magnetic resonance imaging Peer-reviewed

    HM Deloar, T Fujiwara, M Shidahara, T Nakamura, H Watabe, Y Narita, M Itoh, M Miyake, S Watanuki

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE　25　(6)　565-574　1998/06

    DOI： 10.1007/s002590050257 　

    ISSN： 0340-6997

  380. Estimation of organ cumulated activities and absorbed doses on intakes of several C-11 labelled radiopharmaceuticals from external measurement with thermoluminescent dosimeters Peer-reviewed

    T Nakamura, Y Hayashi, H Watabe, M Matsumoto, T Horikawa, T Fujiwara, M Ito, K Yanai

    PHYSICS IN MEDICINE AND BIOLOGY　43　(2)　389-405　1998/02

    DOI： 10.1088/0031-9155/43/2/013 　

    ISSN： 0031-9155

  381. Internal dose estimation including the nasal cavity and major airway for continuous inhalation of (CO2)-O-15, O-15(2) and (CO)-O-15 using the thermoluminescent dosimeter method Peer-reviewed

    HM Deloar, H Watabe, T Nakamura, Y Narita, A Yamadera

    JOURNAL OF NUCLEAR MEDICINE　38　(10)　1603-1613　1997/10

    ISSN： 0161-5505

  382. Performance study of a miniature gamma ray scintillation vivo probe for tumor localization Peer-reviewed

    Hossain M. Deloar, Hiroshi Watabe, Yoshiharu Hayashi, Masayasu Miyake, Takashi Nakamura, Hiromu Takahashi, Takashi Yoshioka, Ryunosuke Kanamaru, Takehiko Fujiwara, Masatoshi Itoh

    Annals of Nuclear Medicine　11　(2)　173-181　1997

    Publisher: Springer Tokyo

    DOI： 10.1007/BF03164830 　

    ISSN： 0914-7187

  383. Noninvasive quantification of rCBF using positron emission tomography Peer-reviewed

    H Watabe, M Itoh, Cunningham, V, AA Lammertsma, P Bloomfield, M Mejia, T Fujiwara, AKP Jones, T Jones, T Nakamura

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　16　(2)　311-319　1996/03

    ISSN： 0271-678X

  384. Internal dosimetry on intakes of various radiopharmaceuticals from external measurement with TLD Peer-reviewed

    T Nakamura, Y Hayashi, H Watabe, M Itoh, T Fujiwara

    IRPA9 - 1996 INTERNATIONAL CONGRESS ON RADIATION PROTECTION / NINTH INTERNATIONAL CONGRESS OF THE INTERNATIONAL RADIATION PROTECTION ASSOCIATION, PROCEEDINGS, VOL 3　C482-C484　1996

  385. Noninvasive Determination or Arterial Input of 15O Tracers, Using a Dual Cutaneous b-Detector Set above the Radial Artery Peer-reviewed

    M. ITOH, H. WATABE, M. MIYAKE, S. HAGIWARA, T. FUJIWARA, R. IWATA, T. IDO, T. NAKAMURA

    QUANTIFICATION OF BRAIN FUNCTION USING PET　1996

  386. Validation of noninvasive quantification of rCBF compared with dynamic/integral method by using positron emission tomography and oxygen-15 labeled water Peer-reviewed

    H. Watabe, M. Itoh, M. Mejia R., T. Fujiwara, T. Jones, T. Nakamura

    Annals of Nuclear Medicine　9　(4)　191-198　1995/12

    DOI： 10.1007/BF03168400 　

    ISSN： 0914-7187 1864-6433

  387. DEVELOPMENT OF SKIN SURFACE RADIATION DETECTOR SYSTEM TO MONITOR RADIOACTIVITY IN ARTERIAL BLOOD ALONG WITH POSITRON EMISSION TOMOGRAPHY Peer-reviewed

    H WATABE, M MIYAKE, Y NARITA, T NAKAMURA, M ITOH

    IEEE TRANSACTIONS ON NUCLEAR SCIENCE　42　(4)　1455-1459　1995/08

    DOI： 10.1109/23.467729 　

    ISSN： 0018-9499

  388. Linearized method: A new approach for kinetic analysis of central dopamine D2 receptor specific binding. Peer-reviewed

    Hiroshi Watabe, Jun Hatazawa, Kiichi Ishiwata, Tatsuo Ido, Masatoshi Itoh, Ren Iwata, Toshihiro Takahashi, Kentaro Hatano, Takashi Nakamura

    IEEE Trans. Medical Imaging　14　(4)　688-696　1995

    DOI： 10.1109/42.476110 　

    ISSN： 0278-0062

  389. SIMPLIFIED NONLINEARITY CORRECTION OF OXYGEN-15-WATER REGIONAL CEREBRAL BLOOD-FLOW IMAGES WITHOUT BLOOD-SAMPLING Peer-reviewed

    MA MEJIA, M ITOH, H WATABE, T FUJIWARA, T NAKAMURA

    JOURNAL OF NUCLEAR MEDICINE　35　(11)　1870-1877　1994/11

    ISSN： 0161-5505

  390. ESTIMATION OF ORGAN BIODISTRIBUTION AND ABSORBED DOSE FROM EXTERNAL MEASUREMENT WITH TLDS IN PET STUDIES Peer-reviewed

    M MATSUMOTO, T NAKAMURA, H WATABE, M ITOH, J HATAZAWA

    MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING　31　S151-S156　1993/07

    ISSN： 0140-0118

  391. DEVELOPMENT OF A MINIATURE GAMMA-RAY ENDOSCOPIC PROBE FOR TUMOR-LOCALIZATION IN NUCLEAR-MEDICINE Peer-reviewed

    H WATABE, T NAKAMURA, H TAKAHASHI, M ITOH, M MATSUMOTO, A YAMADERA

    IEEE TRANSACTIONS ON NUCLEAR SCIENCE　40　(2)　88-94　1993/04

    ISSN： 0018-9499

  392. Instability of Subject's Psychological State During PET Activation Study Monitored with EEG

    M. Itoh, M. Jeong, T. Fujiwara, H. Watabe, N. Okamura, S. Seo, S. Watanuki, H. Fukuda

    Elsevier Science Publishers. Quantification of Brain Function. Tracer Kinetics and Image Analysis in Brain PET　627-632　1993

  393. ESTIMATION OF ORGAN BIODISTRIBUTION OF ACTIVITIES IN HUMAN FROM EXTERNAL MEASUREMENT WITH TLD Peer-reviewed

    T NAKAMURA, M MATSUMOTO, H WATABE, M ITOH, J HATAZAWA

    IRPA8 - EIGHTH INTERNATIONAL CONGRESS OF THE INTERNATIONAL RADIATION PROTECTION ASSOCIATION - WORLDWIDE ACHIEVEMENT IN PUBLIC AND OCCUPATIONAL HEALTH PROTECTION AGAINST RADIATION, VOL I　380-383　1992

  394. ABSORBED DOSE ESTIMATES IN POSITRON EMISSION TOMOGRAPHY STUDIES BASED ON THE ADMINISTRATION OF F-18 LABELED RADIOPHARMACEUTICALS Peer-reviewed

    AA MEJIA, T NAKAMURA, M ITOH, J HATAZAWA, K ISHIWATA, T IDO, M MATSUMOTO, H WATABE, S WATANUKI, S SEO

    JOURNAL OF RADIATION RESEARCH　32　(3)　243-261　1991/09

    DOI： 10.1269/jrr.32.243 　

    ISSN： 0449-3060

  395. Shortening rCBF Measurement Interval in [15O]H2O PET

    Hiroshi Watabe

    DOI： 10.1016/b978-012636651-8/50032-5 　

Show all ︎Show first 5

Misc. 232

  1. 共同利用・共同研究システム形成事業 学際領域展開ハブ形成プログラム RIコラボラティブ学際領域展開プラットフォーム—Radioisotope Collaborative Interdisciplinary Development Platform

    神田 浩樹, 中野 貴志, 福田 光宏, 依田 哲彦, 石岡 典子, 菊永 英寿, 豊嶋 厚史, 永津 弘太郎, 羽場 宏光, 渡部 浩司

    加速器 : 日本加速器学会誌 = journal of the Particle Accelerator Society of Japan　21　(3)　208-211　2024

    Publisher: 東京 : 日本加速器学会

    ISSN： 1349-3833

  2. Range shift detection of SOBP beams in particle therapy by measuring secondary electron bremsstrahlung

    津田路子, 津田路子, 山口充孝, 矢部卓也, 豊川秀訓, 豊川秀訓, 酒井真理, 長尾悠人, 河地有木, 渡部浩司, 加田渉, 神谷富裕

    応用物理学会春季学術講演会講演予稿集(CD-ROM)　70th　2023

    ISSN： 2436-7613

  3. Visualization of Particle Ion Beams Using Imaging Plates

    津田路子, 津田路子, 津田路子, 山口充孝, 矢部卓也, 佐鳥凌太, 長尾悠人, 河地有木, 渡部浩司, 渡部浩司, 酒井真理, 加田渉, 神谷富裕

    アイソトープ・放射線研究発表会(Web)　60th　2023

    ISSN： 2436-4487

  4. 新規PET薬剤[18F]SMBT-1を用いたAD疾患連続体の進行予後予測に関する早期観察結果

    田代学, 田代学, 平岡宏太郎, 平岡宏太郎, 冨田尚希, 石木愛子, TEKEA Berihu, TEKEA Berihu, WU Yingying, 原田龍一, 菊地飛鳥, 菊地飛鳥, 武田和子, 草場美津江, 草場美津江, 菊池昭夫, 古川勝敏, 渡部浩司, 渡部浩司, 麦倉俊司, 小林良太, 川勝忍, 石井賢二, 加藤隆司, 古本祥三, 古本祥三, 岡村信行, 岡村信行

    Dementia Japan　37　(4)　2023

    ISSN： 1342-646X

  5. 前頭側頭葉変性症における[18F]SMBT-1 PET所見

    小林良太, 川勝忍, 森岡大智, 平岡宏太良, 平岡宏太良, 冨田尚希, 四月朔日聖一, 四月朔日聖一, MESFIN Berihu, WU Yingying, 武田和子, 草場美津江, 菊池昭夫, 渡部浩司, 渡部浩司, 麦倉俊司, 古川勝敏, 石井賢二, 加藤隆司, 原田龍一, 古本祥三, 古本祥三, 岡村信行, 岡村信行, 田代学, 田代学

    Dementia Japan　37　(4)　2023

    ISSN： 1342-646X

  6. 認知症疾患の層別化における[18F]SMBT-1の有用性の検討プロジェクトの経過報告 2023

    田代学, 田代学, 平岡宏太良, 平岡宏太良, 冨田尚希, 小林良太, TEKEA Berihu, WU Yingying, 原田龍一, 菊地飛鳥, 菊地飛鳥, 武田和子, 草場美津江, 草場美津江, 菊池昭夫, 古川勝敏, 渡部浩司, 渡部浩司, 麦倉俊司, 川勝忍, 石井賢二, 二橋尚志, 加藤隆司, 古本祥三, 古本祥三, 岡村信行, 岡村信行

    Dementia Japan　37　(4)　2023

    ISSN： 1342-646X

  7. Deep Image Priorを利用したSPECT画像改善

    銭谷勉, 矢部暁登, 對馬結太, 松原佳亮, 越野一博, 渡部浩司

    核医学(Web)　59　(Supplement)　2022

    ISSN： 2189-9932

  8. EM-TV Algorithm for SPECT Image Reconstruction by Using Deep Image Prior

    矢部暁登, 松原佳亮, 越野一博, 渡部浩司, 湯浅哲也, 銭谷勉

    日本医用画像工学会大会予稿集(CD-ROM)　41st　2022

    ISSN： 0288-450X

  9. Production of Medical Radioisotopes with Accelerator Based Neutrons at CYRIC, Tokoku Univ.

    塚田和明, 伊藤正俊, 渡部浩司, 足立智, 松田洋平, 松田洋平, 橋本和幸, 橋本和幸, 川端方子, 川端方子, 永井泰樹, 永井泰樹, 岡田漱平, 本村新, 本村新, 廣瀬耀, 廣瀬耀, 本石章司, 本石章司, 佐伯秀也, 佐伯秀也, 盛田琢造, 足達芳嗣, 川間哲雄, 森雅史, 谷口愛美, 楠岡新也, 菊永英寿

    日本放射化学会討論会(Web)　66th　2022

  10. Nuclides newly available from Tohoku University through the short-lived RI supply platform

    池田隼人, 池田隼人, 菊永英寿, 渡部浩司

    日本放射化学会討論会(Web)　66th　2022

  11. 認知症疾患の層別化における[18F]SMBT-1の有用性の検討プロジェクトの経過報告 2022

    田代学, 田代学, 平岡宏太良, 平岡宏太良, 冨田尚希, 石木愛子, 石木愛子, 小林良太, 四月朔日聖一, 四月朔日聖一, メスフィン ベリフ, 武田和子, 草場美津江, 菊池昭夫, 渡部浩司, 渡部浩司, 麦倉俊司, 古川勝敏, 古川勝敏, 加藤隆司, 石井賢二, 川勝忍, 原田龍一, 古本祥三, 古本祥三, 岡村信行

    Dementia Japan　36　(4)　2022

    ISSN： 1342-646X

  12. Tracking arsenic dynamics in As-hyperaccumulator Pteris vittata by using Positron-Emitting Tracer Imaging System (PETIS)

    黄田毅, 黄田毅, QIAN Zhaojie, CHIEN Meifang, 宮内啓介, 宮内啓介, 遠藤銀朗, 池田隼人, 池田隼人, 菊永英寿, 渡部浩司, 鈴井伸郎, YIN Yong-Gen, 河地有木, 北島信行, 井上千弘

    アイソトープ・放射線研究発表会(Web)　58th　2021

    ISSN： 2436-4487

  13. Production and applications of radioisotopes at CYRIC, ELPH, Tohoku University

    渡部浩司, 菊永英寿

    アイソトープ・放射線研究発表会(Web)　58th　2021

    ISSN： 2436-4487

  14. Improving Image Quality of SPECT by Deep Image Prior

    矢部暁登, 對馬結太, 福原健太, 松原佳亮, 越野一博, 渡部浩司, 銭谷勉

    日本医用画像工学会大会予稿集(CD-ROM)　40th　2021

    ISSN： 0288-450X

  15. 金属ジルコニウムおよび酸化ジルコニウムをターゲットとしたキャリアフリーMo-99製造法の開発

    池田隼人, 池田隼人, 菊永英寿, 渡部浩司

    核医学(Web)　57　(Supplement)　2020

    ISSN： 2189-9932

  16. 抗ヒスタミン薬が認知課題遂行中の脳エネルギー消費に与える影響に関する脳PET研究

    鈴木頌也, 菊地飛鳥, 稲見暁惠, MOHSEN Attayeb, 松田林, 平岡宏太良, 四月朔日聖一, 三宅正泰, 三宅正泰, 渡部浩司, 谷内一彦, 谷内一彦, 田代学

    日本ヒスタミン学会プログラム・講演要旨集　22nd　2020

  17. Development of Compton camera using high resolution GAGG crystal (2)

    山本広平, 伊藤正俊, 池田隼人, 渡部浩司, ZAREI Hajar, 松田洋平, 黒澤駿斗, 中川杏菜, 野坂恭子, 前田流, 小野寺史龍, 今間可奈子, 蜂須賀大暁

    日本物理学会講演概要集(CD-ROM)　75　(2)　2020

    ISSN： 2189-079X

  18. プラナー像定量のためのconjugate法における減弱・散乱線補正が定量精度に及ぼす影響の基礎検討

    佐々木里奈, 筒井亮佑, 小田桐逸人, KIM KyeongMin, 渡部浩司, 志田原美保

    核医学技術　40　2020

    ISSN： 0289-100X

  19. JRSM/JHPS-Questionnaire on Future Collaboration-Report of the Results

    飯本武志, 柴和弘, 渡部浩司, 藤淵俊王

    日本放射線安全管理学会学術大会講演予稿集　19th　2020

  20. Investigation in Radiocesium Particle in Cherry Tree Bark in Fukushima Prefecture

    杉浦広幸, 渡部浩司, 千田浩一

    日本放射線安全管理学会学術大会講演予稿集　19th　2020

  21. Chemical separation of As-74 using solvent extraction and column chromatography

    池田隼人, 池田隼人, 菊永英寿, 黄田毅, QIAN Z. J., CHIEN M. F., 井上千弘, 鈴井伸郎, 河地有木, RAMDHANI Danni, 渡部浩司

    日本放射化学会討論会(Web)　64th　2020

  22. Imaging the arsenic translocation and accumulation in arsenic hyperaccumulator Pteris vittata using Positron Emitting Tracer Imaging System(PETIS)

    黄田毅, QIAN Z. J., CHIEN M. F., 井上千弘, 池田隼人, 池田隼人, 渡部浩司, 菊永英寿, 鈴井伸郎, YIN Y. G., 河地有木, 北島信行

    日本放射化学会討論会(Web)　64th　2020

  23. 抗ヒスタミン薬が認知課題遂行中の脳エネルギー消費に与える影響 FDG PET研究

    田代 学, 鈴木 頌也, Chen Edmond, 菊地 飛鳥, 稲見 暁惠, 三宅 正泰, Nasir Fairuz Mohd, 平岡 宏太良, 四月朔日 聖一, 谷内 一彦, 渡部 浩司

    核医学　56　(Suppl.)　S161-S161　2019/10

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  24. Simultaneous Production and Separation of Carrier-free Alkali Metal Tracer Using Photonuclear Reaction

    池田隼人, 池田隼人, 菊永英寿, 渡部浩司

    日本放射化学会討論会(Web)　63rd　2019

  25. Total Variationを用いた画像再構成による少数投影骨SPECTの検討

    金澤道和, 笹谷典太, 細川翔太, 渡部浩司, 湯浅哲也, 高橋康幸, 銭谷勉

    核医学(Web)　56　(Supplement)　2019

    ISSN： 2189-9932

  26. 重金属高蓄積植物ハクサンハタザオ体内におけるカドミウムの吸収過程の追跡

    QIAN Zhaojie, 黄田毅, 池田隼人, 渡部浩司, 鈴井伸郎, YIN Yong-Gen, 河地有木, CHIEN Mei-Fang, 井上千弘

    アイソトープ・放射線研究発表会要旨集　56th　2019

  27. PETISによる亜鉛とカドミウムの高蓄積植物ハクサンハタザオの体内における亜鉛の挙動の追跡

    黄田毅, QIAN Zhaojie, 渡部浩司, 鈴井伸郎, YIN Yong-Gen, 河地有木, CHIEN Meifang, 井上千弘

    アイソトープ・放射線研究発表会要旨集　56th　2019

  28. 抗ヒスタミン薬が認知課題遂行中の脳エネルギー消費に与える影響:FDG PET研究

    田代学, 鈴木頌也, CHEN Edmond, 菊地飛鳥, 稲見暁惠, 三宅正泰, NASIR Fairuz Mohd, 平岡宏太良, 四月朔日聖一, 谷内一彦, 渡部浩司

    核医学(Web)　56　(Supplement)　2019

    ISSN： 2189-9932

  29. EM‐TVアルゴリズムを用いた少数投影での骨SPECT画像再構成の検討

    金澤道和, 笹谷典太, 細川翔太, 渡部浩司, 湯浅哲也, 高橋康幸, 銭谷勉

    日本医用画像工学会大会予稿集(CD-ROM)　38th　352‐359-359　2019

    ISSN： 0288-450X

  30. FDG-PETとNIRSを用いた抗ヒスタミン薬服用下での脳機能変化

    菊地 飛鳥, 稲見 暁惠, 松田 林, 平岡 宏太良, 四月朔日 聖一, 田代 学, Mohsen Attayeb, 三宅 正泰, Nasir Mohd Fairuz, 渡部 浩司, 谷内 一彦

    核医学　55　(1)　38-38　2018/12

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  31. 新規画像モダリティの開発から見えてきた乳癌像 標本PEMを用いた乳房温存手術の最適化のシミュレーション

    渡部 剛, 伊藤 正敏, 渡部 浩司, 宮下 穣, 原田 成美, 濱中 洋平, 佐藤 章子, 多田 寛, 石田 孝宣

    日本乳癌学会総会プログラム抄録集　26回　305-305　2018/05

    Publisher: (一社)日本乳癌学会

  32. 新規画像モダリティの開発から見えてきた乳癌像 標本PEMを用いた乳房温存手術の最適化のシミュレーション

    渡部 剛, 伊藤 正敏, 渡部 浩司, 宮下 穣, 原田 成美, 濱中 洋平, 佐藤 章子, 多田 寛, 石田 孝宣

    日本乳癌学会総会プログラム抄録集　26回　305-305　2018/05

    Publisher: (一社)日本乳癌学会

  33. Production of carrier-free RI tracer of alkali metal using bemsstrahlung

    池田隼人, 池田隼人, 菊永英寿, 渡部浩司

    日本放射化学会年会・放射化学討論会研究発表要旨集(Web)　2018-62nd　2018

  34. 小動物用PET/MRI用装置の性能評価

    渡部浩司, 銭谷勉

    核医学(Web)　55　(Supplement)　2018

    ISSN： 2189-9932

  35. ハクサンハタザオにおけるカドミウムと亜鉛の輸送過程の追跡

    銭照杰, 黄田毅, 鈴井伸郎, 尹永根, 河地有木, 池田隼人, 池田隼人, 渡部浩司, 北島信行, 簡梅芳, 井上千弘

    環境バイオテクノロジー学会大会プログラム講演要旨集　2018　2018

  36. 即発制動放射線による粒子線治療におけるリアルタイム・ターゲッティングシステム開発

    後藤紳一, 山口充孝, 渡部浩司, 河地有木

    日本放射線腫瘍学会高精度放射線外部照射部会学術大会プログラム・抄録集　31st (CD-ROM)　2018

  37. アイソトープ総合センター情報連携のための専用ネットワークの構築

    渡部浩司, 三宅正泰

    日本アイソトープ協会放射線安全取扱部会年次大会要旨集　2018　2018

  38. FDG-PETとNIRSを用いた抗ヒスタミン薬服用下での脳機能変化

    菊地飛鳥, 稲見暁惠, 松田林, 平岡宏太良, 四月朔日聖一, 田代学, MOHSEN Attayeb, 三宅正泰, NASIR Fairuz Mohd, 渡部浩司, 谷内一彦

    核医学(Web)　55　(1)　2018

    ISSN： 2189-9932

  39. FDG-PETとNIRSの同時測定で発見された抗ヒスタミン薬服用下での脳糖代謝変化と脳血流変化のミスマッチ所見

    菊地飛鳥, 稲見暁惠, 三宅正泰, MOHSEN Attayeb, NASIR Fairuz Mohd, 松田林, 平岡宏太良, 四月朔日聖一, 谷内一彦, 渡部浩司, 田代学

    日本ヒト脳機能マッピング学会プログラム・抄録集　20th　2018

  40. レボセチリジンの鎮静作用に関する脳ブドウ糖代謝および脳血流の変化の観察

    田代 学, 菊地 飛鳥, 稲見 暁惠, 三宅 正泰, Mohsen Attayeb, Nasir Fairuz, 松田 林, 平岡 宏太良, 四月朔日 聖一, 渡部 浩司, 谷内 一彦

    臨床薬理　48　(Suppl.)　S280-S280　2017/11

    Publisher: (一社)日本臨床薬理学会

    ISSN： 0388-1601

  41. Visualization of Zinc translocation dynamic in hyperaccumulator Arabidopsis halleri ssp.gemmifera and non-accumulator Arabidopsis thaliana

    Y. Huang, ZJ. Qian, MF. Chien, K. Sugawara, N. Suzui, YG. Yin, N. Kawachi, H. Watabe, N. Kitajima, C. Inoue

    Proceedings of 14th International Phytotechnologies Conference　2017/09

  42. 15O水PETによる肺動脈血流低下部での気管支動脈由来血流測定

    松永 恵子, 梁川 雅弘, 渡部 浩司, 下瀬川 恵久, 畑澤 順

    核医学　54　(Suppl.)　S179-S179　2017/09

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

  43. ラットPETを用いたヒト内部被曝線量の非侵襲的推定手法の検討

    志田原 美保, 猪又 嵩斗, 小山 千莉, 船木 善仁, 田代 学, 古本 祥三, 谷内 一彦, 権田 幸祐, 渡部 浩司

    核医学　54　(Suppl.)　S199-S199　2017/09

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

  44. 18F-FDG PETを用いた冠動脈周囲脂肪組織の炎症性変化の検討 薬剤溶出性ステント留置後のブタ冠動脈過収縮モデルを用いて

    大山 宗馬, 松本 泰治, 天水 宏和, 宇塚 裕紀, 西宮 健介, 諸沢 薦, 平野 道基, 渡部 浩司, 船木 善仁, 高橋 潤, 伊藤 健太, 下川 弘明

    日本心臓核医学会ニュースレター　19　(2)　15-16　2017/06

    Publisher: 日本心臓核医学会

    ISSN： 1346-2733

  45. Pulmonary perfusion measured by 15O-H2O PET with and without a correction for tissue fraction

    松永 恵子, 下瀬川 恵久, 梁川 雅弘, 渡部 浩司, 藤埜 浩一, 加藤 弘樹, 畑澤 順

    核医学　54　(1)　598-599　2017/02

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

  46. 15O水PETによる肺血流の定量測定における入力関数の検討

    松永恵子, 松永恵子, 梁川雅弘, 渡部浩司, 下瀬川恵久, 畑澤順

    核医学(Web)　54　(Supplement)　2017

    ISSN： 2189-9932

  47. 15O水PETによる肺動脈血流低下部での気管支動脈由来血流測定

    松永恵子, 松永恵子, 梁川雅弘, 渡部浩司, 下瀬川恵久, 畑澤順

    核医学(Web)　54　(Supplement)　2017

    ISSN： 2189-9932

  48. 植物体内物質の動態を可視化するチェレンコフ光イメージング技術の開発

    栗田圭輔, 鈴木伸郎, 尹永根, 石井里美, 渡部浩司, 山本誠一, 河地有木

    日本土壌肥料学会講演要旨集　63　2017

    ISSN： 0288-5840

  49. チェレンコフ光で見る植物体内の放射性セシウム動態

    栗田圭輔, 鈴井伸郎, 尹永根, 石井里美, 渡部浩司, 山本誠一, 河地有木

    日本土壌肥料学会講演要旨集　63　2017

    ISSN： 0288-5840

  50. PoE省配線ネットワークカメラを用いた管理区域出入り口監視カメラ設置の経験

    三宅正泰, 渡部浩司

    日本アイソトープ協会放射線安全取扱部会年次大会要旨集　2017　2017

  51. Supply Platform of Short-lived Radioisotopes for Fundamental Research

    14　(2)　81-86　2017

    Publisher: 日本加速器学会

    ISSN： 1349-3833

  52. 蛍光CT励起X線としての管球X線と放射光のシミュレーションによる比較

    高岡 翼, 笹谷 典太, 砂口 尚輝, 越野 一博, 渡部 浩司, 湯浅 哲也, 銭谷 勉

    電気関係学会東北支部連合大会講演論文集　2017　(0)　239-239　2017

    Publisher: 電気関係学会東北支部連合大会実行委員会

    DOI： 10.11528/tsjc.2017.0_239 　

  53. Evidence for Involvement of Inflammatory Changes of Perivascular Adipose Tissue in the Pathogenesis of Coronary Hyperconstricting Responses Induced by Drug-Eluting Stent in Pigs in vivo - Impact of Fluorodeoxyglucose Positron Emission Tomography Imaging

    Kazuma Ohyama, Yasuharu Matsumoto, Hirokazu Amamizu, Hironori Uzuka, Kensuke Nishimiya, Susumu Morosawa, Michinori Hirano, Hiroshi Watabe, Yoshihito Funaki, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa

    CIRCULATION　134　2016/11

    ISSN： 0009-7322

    eISSN： 1524-4539

  54. Evidence for Involvement of Inflammatory Changes of Perivascular Adipose Tissue in the Pathogenesis of Coronary Hyperconstricting Responses Induced by Drug-Eluting Stent in Pigs in vivo -Impact of Fluorodeoxyglucose Positron Emission Tomography Imaging

    Kazuma Ohyama, Yasuharu Matsumoto, Hirokazu Amamizu, Hironori Uzuka, Kensuke Nishimiya, Susumu Morosawa, Michinori Hirano, Hiroshi Watabe, Yoshihito Funaki, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa

    CIRCULATION　134　2016/11

    ISSN： 0009-7322

    eISSN： 1524-4539

  55. NEMA NU4-2008に基づいた小動物用PET装置ClairvivoPETの性能評価

    志田原 美保, Nai Ying Hway, 四月朔日 聖一, 石川 洋一, 田代 学, 古本 祥三, 谷内 一彦, 権田 幸祐, 渡部 浩司

    核医学　53　(Suppl.)　S312-S312　2016/10

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  56. Renal denervation suppresses coronary hyperconstricting responses after DES implantation in pigs in vivo - evidence for the kidney-brain-heart interactions

    H. Uzuka, Y. Matsumoto, K. Ohyama, K. Nishimiya, H. Amamizu, S. Morosawa, M. Hirano, K. Hao, R. Tsuburaya, K. Ito, J. Takahashi, Y. Funaki, H. Watabe, H. Shimokawa

    EUROPEAN HEART JOURNAL　37　1003-1004　2016/08

    ISSN： 0195-668X

    eISSN： 1522-9645

  57. Evidence for involvement of inflammatory changes of perivascular adipose tissue in the pathogenesis of DES-induced hyperconstricting responses in pigs in vivo - impact of 18F-FDG PET imaging

    K. Ohyama, Y. Matsumoto, H. Amamizu, H. Uzuka, K. Nishimiya, S. Morosawa, M. Hirano, H. Watabe, Y. Funaki, J. Takahashi, K. Ito, H. Shimokawa

    EUROPEAN HEART JOURNAL　37　786-786　2016/08

    ISSN： 0195-668X

    eISSN： 1522-9645

  58. Luminescence Imaging of Water During Proton Beam Irradiation for Range Estimation

    S. Yamamoto, T. Toshito, M. Komori, H. Watabe

    MEDICAL PHYSICS　43　(6)　3717-3717　2016/06

    DOI： 10.1118/1.4957340 　

    ISSN： 0094-2405

    eISSN： 2473-4209

  59. 短寿命RI供給プラットフォームの紹介

    中野貴志, 福田光宏, 青井考, 鈴木智和, 高橋成人, 酒見泰寛, 羽場宏光, 上垣外修一, 渡部浩司, 伊藤正俊, 菊永英寿

    日本アイソトープ協会放射線安全取扱部会年次大会要旨集　2016　2016

  60. 植物チェレンコフイメージング技術で見る植物体内の放射性セシウム動態

    栗田圭輔, 鈴井伸郎, 尹永根, 石井里美, 渡部浩司, 山本誠一, 河地有木

    日本土壌肥料学会講演要旨集　62　2016

    ISSN： 0288-5840

  61. チェレンコフ光で植物体内の放射性セシウム動態を見る

    栗田圭輔, 鈴井伸郎, 尹永根, 石井里美, 河地有木, 渡部浩司, 山本誠一

    放射線プロセスシンポジウム講演要旨・ポスター発表要旨集　16th　2016

  62. Biomathematical modeling approach to predict clinical SUVR in amyloid PET imaging towards efficient radioligand discovery and development

    Y. Arakawa, M. Shidahara, Y. Nai, S. Furumoto, C. Seki, N. Okamura, M. Tashiro, M. Tashiro, Y. Kudo, K. Yanai, K. Gonda, H. Watabe

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　42　S70-S70　2015/10

    ISSN： 1619-7070

    eISSN： 1619-7089

  63. 生体数学モデルを用いたアミロイドPETイメージングにおける臨床SUVR予測

    荒川 悠真, 志田原 美保, Nai Ying Hwey, 古本 祥三, 関 千江, 岡村 信行, 田代 学, 工藤 幸司, 谷内 一彦, 権田 幸祐, 渡部 浩司

    核医学　52　(3)　260-260　2015/09

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  64. Development of ultrahigh resolution Si-PM-based small animal PET system using 0.32mm pixel scintillators

    Seiichi Yamamoto, Hiroshi Watabe, Tadashi Watabe, Hayato Ikeda, Yasukazu Kanai, Katsuhiko Kato, Jun Hatazawa

    JOURNAL OF NUCLEAR MEDICINE　56　(3)　2015/05

    ISSN： 0161-5505

    eISSN： 1535-5667

  65. Measurement of Free Fraction in Plasma for Biomathematical Prediction of SUVR of Amyloid PET Radiotracers

    Nai Y.-H., Shidahara M., Seki C., Watanuki S., Funaki Y., Ishikawa Y., Furumoto S., Watabe H.

    CYRIC annual report　2014　73-77　2015

    Publisher: Cyclotron and Radioisotope Center, Tohoku University

  66. ガンマカメラによる植物体内放射性セシウムの動態解明

    河地有木, YIN Yong-Gen, 鈴井伸郎, 石井里美, 渡部浩司, 山本誠一, 藤巻秀

    アイソトープ・放射線研究発表会要旨集　52nd　2015

  67. チェレンコフ光で植物体内の元素動態を見る

    栗田圭輔, 河地有木, YIN Yong-Gen, 鈴井伸郎, 石井里美, 渡部浩司, 山本誠一, 藤巻秀

    アイソトープ・放射線研究発表会要旨集　52nd　2015

  68. ガンマカメラを用いた放射性セシウムの植物体内動態の可視化技術

    河地有木, 尹永根, 鈴井伸郎, 石井里美, 山本誠一, 渡部浩司, 吉原利一, 藤巻秀

    日本土壌肥料学会講演要旨集　61　2015

    ISSN： 0288-5840

  69. 放射性セシウム動態解析に向けた植物チェレンコフイメージング技術の開発

    栗田圭輔, 河地有木, 尹永根, 鈴木伸郎, 石井里美, 渡部浩司, 山本誠一, 藤巻秀

    日本土壌肥料学会講演要旨集　61　2015

    ISSN： 0288-5840

  70. 放射線生物影響の分子レベル解明に向けて PETによる生体イメージング

    渡部 浩司, 古本 祥三, 谷内 一彦

    日本放射線影響学会大会講演要旨集　57回　85-85　2014/09

    Publisher: (一社)日本放射線影響学会

    ISSN： 1347-8680

  71. Radioactivity concentration of small amount of blood samples in rodents PET study: A comparison between conventional well counter method and CCD camera based method

    Takahiro Morita, Tadashi Watabe, Hiroshi Watabe, Yasukazu Kanai, Kayako Isohashi, Hiroki Kato, Eku Shimosegawa, Jun Hatazawa

    JOURNAL OF NUCLEAR MEDICINE　55　2014/05

    ISSN： 0161-5505

    eISSN： 1535-5667

  72. Ultrahigh resolution Cerenkov light imaging system for positron radionuclides: Potential applications and limitations

    Seiichi Yamamoto, Tadashi Watabe, Hayato Ikeda, Yasukazu Kanai, Hiroshi Watabe, Yoshimune Ogata, Katsuhiko Kato, Jun Hatazawa

    JOURNAL OF NUCLEAR MEDICINE　55　2014/05

    ISSN： 0161-5505

    eISSN： 1535-5667

  73. Radioactivity concentration of small amount of blood samples in rodents PET study: A comparison between conventional well counter method and CCD camera based method

    Takahiro Morita, Tadashi Watabe, Hiroshi Watabe, Yasukazu Kanai, Kayako Isohashi, Hiroki Kato, Eku Shimosegawa, Jun Hatazawa

    JOURNAL OF NUCLEAR MEDICINE　55　2014/05

    ISSN： 0161-5505

    eISSN： 1535-5667

  74. Quantitative myocardial perfusion imaging for the assessment of myocardial regeneration therapy: N-13-NH3 PET in the myocardial infarction model of rat

    Tadashi Watabe, Satoshi Kainuma, Shigeru Miyagawa, Genki Horitsugi, Hayato Ikeda, Hiroshi Watabe, Satsuki Fukushima, Atsuhiro Saito, Yoshiki Sawa, Jun Hatazawa

    JOURNAL OF NUCLEAR MEDICINE　55　2014/05

    ISSN： 0161-5505

    eISSN： 1535-5667

  75. Boron concentration in experimental tumor measured by means of F-18 FBPA and PET/CT

    K. Hanaoka, T. Watabe, S. Naka, Y. Kanai, H. Ikeda, H. Watabe, H. Kato, E. Shimosegawa, J. Hatazawa

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　40　S454-S454　2013/10

    ISSN： 1619-7070

    eISSN： 1619-7089

  76. 核医学的手法を用いた生体内ナノ粒子動態の観察

    金井泰和, 戸井田力, 仲定宏, 赤木隆美, 池田隼人, 堺俊博, 三宅義徳, 渡部浩司, 下瀬川恵久, 明石満, 畑澤順

    核医学　50　(3)　198-S188　2013/09/30

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  77. 3次元トラッキング装置を用いた脳PET検査の体動補正システムの開発

    水田 哲郎, 橘 一成, 大谷 篤, 田中 和巳, 四月朔日 聖一, 渡部 浩司, 石川 洋一, 平岡 宏太良, 田代 学, 谷内 一彦

    核医学　50　(3)　S224-S224　2013/09

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

  78. 3次元トラッキング装置を用いた脳PET検査の体動補正システムの性能評価

    四月朔日, 聖一, 田代 学, 渡部 浩司, 石川 洋一, 平岡 宏太良, 谷内 一彦, 水田 哲郎, 佐藤 友彦

    核医学　50　(3)　S224-S224　2013/09

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

  79. 疎水化ポリγ‐グルタミン酸ナノ粒子の体内動態のイメージング

    戸井田力, 中尾剣士, 馬原淳, 山岡哲二, 金井泰和, 渡部浩司, 畑澤順, 明石満

    高分子学会予稿集(CD-ROM)　62　(1)　ROMBUNNO.1PC121　2013/05/14

  80. Comparison of C-11 labeling methods

    Yasukazu Kanai, Hiroshi Watabe, Sadahiro Naka, Yoshinori Miyake, Hiroaki Kato, Kayako Isohashi, Eku Shimosegawa, Jun Hatazawa

    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS　56　S97-S97　2013/05

    ISSN： 0362-4803

  81. Radiation Dosimetry of the F-18 Labelled Amyloid Imaging Probe [18F]FACT in Humans

    Shidahara M., Tashiro M., Okamura N., Furumoto S., Furukawa K., Watanuki S., Hiraoka K., Miyake M., Watabe H., Iwata R., Arai H., Kudo Y., Gonda K., Tamura H., Yanai K.

    CYRIC annual report　2012　137-143　2013

    Publisher: Cyclotron and Radioisotope Center, Tohoku University

  82. 植物体における放射性セシウム動態のガンマカメラを用いたイメージング

    藤巻秀, 河地有木, 尹永根, 鈴井伸郎, 石井里美, 渡部浩司, 山本誠一

    日本土壌肥料学会講演要旨集　59　2013

    ISSN： 0288-5840

  83. 東北大学PEMの計数率補正とSUV表示の検討

    伊藤繁記, 三宅正泰, 渡部浩司, 馬場護, 伊藤正敏, 山本誠一

    核医学　50　(3)　2013

    ISSN： 0022-7854

  84. 対向型乳腺専用PET(PEM)による早期乳癌の検出能力の検討

    伊藤正敏, 伊藤正敏, 伊藤繁記, 三宅正泰, 田代学, 渡部浩司, 矢野文月, 山本誠一

    核医学　50　(3)　2013

    ISSN： 0022-7854

  85. 第14回放射線プロセスシンポジウム NaI(Tl)spectrometerとガンマカメラを駆使した農地汚染問題への取り組み

    YIN Yong‐Gen, 鈴井伸郎, 河地有木, 山口充孝, 田野井慶太朗, 石井里美, 中西友子, 茅野充男, 中村進一, 渡部浩司, 山本誠一, 藤巻秀

    放射線と産業　(133)　45-48　2012/12/01

    ISSN： 0286-8873

  86. Effects of Pedicle Omentum Flap Combined With Cell Sheet Implantation on. Vessel Stability, Myocardial Perfusion, and Left Ventricular Reverse Remodeling in. Rat Myocardial Infarction Model

    Satoshi Kainuma, Shigeru Miyagawa, Satsuki Fukushima, Atsuhiro Saito, Yasuhiro Shudo, Akima Harada, Tsuyoshi Ishikawa, Tadashi Watabe, Hiroshi Watabe, Jun Hatazawa, Takashi Sonobe, Hirotsugu Tsuchimochi, Mikiyasu Shirai, Tatsuya Shimizu, Teruo Okano, Koichi Toda, Yoshiki Sawa

    CIRCULATION　126　(21)　2012/11

    ISSN： 0009-7322

    eISSN： 1524-4539

  87. Quantification of Boron-10 concentration in normal rats after 4-borono-2-18F-fluoro-phenylalanine injection using PET/MRI

    K. Hanaoka, T. Watabe, S. Naka, Y. Kanai, H. Watabe, H. Kato, E. Shimosegawa, J. Hatazawa

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　39　S443-S443　2012/10

    ISSN： 1619-7070

  88. PET診断用ポルフィリン誘導体の開発

    HIROHARA SHIHO, TAMURA MASATO, TAKAHASHI NARUTO, NAKAI KOJI, KANAI YASUKAZU, WATABE HIROSHI, TANIHARA MASAO, KAKIUCHI KIYOMI, MATSUI HIROFUMI, SHINOHARA ATSUSHI, HATAZAWA JUN

    日本レーザー医学会誌　33　(2)　216　2012/08/31

    ISSN： 0288-6200

  89. 15O水PETによる肺腫瘍血流量測定における入力関数の検討

    松永恵子, 渡部浩司, 梁川雅弘, 下瀬川恵久, 畑澤順

    核医学　49　(3)　219　2012/08/31

    ISSN： 0022-7854

  90. 15O標識ガス定常吸入法によるラット脳血流・酸素代謝評価

    渡部直史, 渡部浩司, 金井泰和, 下瀬川恵久, 花岡宏平, 上口貴志, 渡辺晋一郎, 堀次元気, 加藤弘樹, 巽光朗, 畑澤順

    核医学　49　(3)　214　2012/08/31

    ISSN： 0022-7854

  91. Wavelet-based resolution recovery using an anatomical prior provides quantitative recovery for human population phantom PET [C-11]raclopride data

    Miho Shidahara, Charalampos Tsoumpas, Colm McGinnity, Takashi Kato, Hajime Tamura, Alexander Hammers, Hiroshi Watabe, Federico Turkheimer

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　32　S138-S139　2012/08

    ISSN： 0271-678X

  92. FDG‐PETで坐骨神経に沿って異常集積を呈した1例

    今泉昌男, 巽光朗, 柴田大, 藤田二郎, 金井泰和, 仲定宏, 加藤弘樹, 渡部直史, 礒橋佳也子, 渡辺晋一郎, 花本敦, 花岡宏平, 渡部浩司, 下瀬川恵久, 金倉譲, 畑澤順

    核医学症例検討会症例集　33　(1)　1-2　2012/08

    ISSN： 0910-2213

  93. Quantitative evaluation of cerebral blood flow and oxygen metabolism in the normal anesthetized rat: O-15-labeled gas inhalation PET with MRI fusion

    Tadashi Watabe, Eku Shimosegawa, Hiroshi Watabe, Yasukazu Kanai, Kohei Hanaoka, Takashi Ueguchi, Masao Imaizumi, Hiroki Kato, Mitsuaki Tatsumi, Jun Hatazawa

    JOURNAL OF NUCLEAR MEDICINE　53　2012/05

    ISSN： 0161-5505

    eISSN： 1535-5667

  94. thyroid gland imaging with 124I using semiconductor PET scanner and PET-MR

    Yasukazu Kanai, Naruto Takahashi, Tadashi Watabe, Hiroshi Watabe, Seiichi Yamamoto, Eku Shimosegawa, Atsushi Shinohara, Kozi Nakai, Jun Hatazawa

    JOURNAL OF NUCLEAR MEDICINE　53　2012/05

    ISSN： 0161-5505

    eISSN： 1535-5667

  95. Rat thyroid gland imaging with 124I using semiconductor PET scanner and PET-MR

    Yasukazu Kanai, Naruto Takahashi, Tadashi Watabe, Hiroshi Watabe, Seiichi Yamamoto, Eku Shimosegawa, Atsushi Shinohara, Kozi Nakai, Jun Hatazawa

    JOURNAL OF NUCLEAR MEDICINE　53　2012/05

    ISSN： 0161-5505

    eISSN： 1535-5667

  96. Dynamic whole-body imaging of 18kDa translocator protein using C11-PBR28 and 3D-PET/CT in Asian

    Masao Imaizumi, Yasukazu Kanai, Sadahiro Naka, Tadashi Watabe, Kayako Isohashi, Hiroki Kato, Mitsuaki Tatsumi, Hiroshi Watabe, Eku Shimosegawa, Jun Hatazawa

    JOURNAL OF NUCLEAR MEDICINE　53　2012/05

    ISSN： 0161-5505

    eISSN： 1535-5667

  97. パーキンソン病モデル霊長類動物における骨髄間質幹細胞由来A9ドーパミン神経細胞自家移植

    林拓也, 若尾昌平, 光永佳奈枝, 北田正章, 合瀬恭幸, 渡部浩司, 松瀬大, 繁本妙子, 尾上浩隆, 田畑泰彦, 出澤真理

    JSMI Report　5　(2)　99-99　2012/05

    Publisher: 日本分子イメージング学会

    ISSN： 1882-6490

  98. [5-11C-methoxy]donepezilとPETを用いたアセチルコリンエステラーゼに対するドネペジルの結合の定量解析

    平岡 宏太良, 四月朔日, 聖一, 田代 学, 岡村 信行, 谷内 一彦, 船木 善仁, 森 悦朗, 渡部 浩司

    Japanese Journal of Radiology　30　(Suppl.I)　15-15　2012/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  99. 核医学的手法を用いた放射性ヨウ素のラット体内動態の検討

    金井泰和, 渡部直史, 高橋成人, 加藤弘樹, 礒橋佳也子, 仲定宏, 渡部浩司, 下瀬川恵久, 篠原厚, 畑澤順

    日本放射化学会年会・放射化学討論会研究発表要旨集　2012-56th　2012

    ISSN： 1345-2762

  100. 多目的合成装置UG-M1を用いた18F-FDG合成条件の検討

    金井泰和, 渡部浩司, 仲定宏, 礒橋佳也子, 加藤弘樹, 下瀬川恵久, 畑澤順

    日本薬学会年会要旨集　132nd　(4)　2012

    ISSN： 0918-9823

  101. ガンマカメラを用いた植物中放射性セシウムイメージングの試み

    河地有木, 尹永根, 鈴井伸郎, 石井里美, 渡部浩司, 山本誠一, 藤巻秀

    日本土壌肥料学会講演要旨集　58　2012

    ISSN： 0288-5840

  102. NaI(Tl)spectrometerとガンマカメラを駆使した農地汚染問題への取り組み

    尹永根, 河地有木, 鈴井伸郎, 石井里美, 山口充孝, 藤巻秀, 田野井慶太朗, 中西友子, 茅野充男, 中村進一, 渡部浩司, 山本誠一

    放射線プロセスシンポジウム講演要旨・ポスター発表要旨集　14th　2012

  103. [5-11C-methoxy]donepezilとPETを用いたアセチルコリンエステラーゼに対するドネペジルの結合の定量解析

    平岡 宏太郎, 岡村 信行, 船木 善仁, 四月朔日 聖一, 田代 学, 森 悦朗, 谷内 一彦, 渡部 浩司

    核医学　48　(4)　438-438　2011/11

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  104. CBF/CMRO2迅速検査のための非侵襲入力関数推定法の検討

    久冨 信之, 渡部 浩司, 林 拓也, 笹川 泰弘, 山本 由佳, 西山 佳宏, 飯田 秀博

    核医学　48　(3)　S292-S292　2011/09

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

  105. Regional difference in cerebrovascular reactivity by acetazolamide in normal volunteers: A PET study with H215O

    Jun Hatazawa, Eku Shimosegawa, Hiroshi Watabe, Hiroki Kato, Masao Imaizumi, Kayako Isohashi

    JOURNAL OF NUCLEAR MEDICINE　52　2011/05

    ISSN： 0161-5505

    eISSN： 1535-5667

  106. Non-invasive estimation of input function for rapid CBF-CMRO2 measurement using PET with DARG

    N. Kudomi, H. Watabe, T. Hayashi, Y. Sasakawa, Y. Yamamoto, Y. Nishiyama, H. Iida

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　37　S338-S338　2010/10

    ISSN： 1619-7070

  107. 201Tl CT/SPECT心筋血流量測定における息止め収集CT画像を用いた吸収補正の妥当性検証

    越野一博, 銭谷勉, 平野祥之, 能勢直子, 石田健二, 佐々木和成, 渡部浩司, 福本真司, 福島和人, 飯田秀博

    核医学　47　(3)　S230　2010/09/30

    ISSN： 0022-7854

  108. 頭部用高解像度定量SPECT装置(ProSPECT)の開発

    平野祥之, 銭谷勉, 石田健二, 寺本昇, 越野一博, 工藤博幸, 湊小太郎, 渡部浩司, 畑澤順

    核医学　47　(3)　S228　2010/09/30

    ISSN： 0022-7854

  109. 高解像度定量画像再構成法のI‐123脳SPECT対応とファントム実験による定量精度評価

    銭谷勉, 崎本智則, 石田健二, 平野祥之, ANTTI Sohlberg, 渡部浩司, 湊小太郎, 飯田秀博

    核医学　47　(3)　S207　2010/09/30

    ISSN： 0022-7854

  110. SPECT検査の精度向上と施設間誤差のない標準的画像診断法の確立

    飯田秀博, 渡部浩司, 銭谷勉, 越野一博, 平野祥之, 石田良雄, 宮本恵宏, 野口輝夫, 森脇博, 横田千晶, 福島和人, 中川原譲二, 山田章吾, 松田博史, 中島孝, 丸野廣大, 畑澤順, 橋川一雄, 鈴木倫保

    新しい医療機器研究　15　95-96　2010/03/25

    Publisher: (財)医療機器センター情報サービス部

    ISSN： 0918-435X

  111. 高磁場MRIと核医学・分子イメージングに基づく動脈硬化の高感度かつ定量的な診断と新しい予防戦略の構築

    飯田秀博, 渡部浩司, 寺本昇, 越野一博, 平野祥之, 野々木宏, 野口輝夫, 内藤博昭, 山田直明, 福島和人, 植田初江, 飯原弘二, 宮本恵宏, 古本祥三, 田村元, 久冨信之

    新しい医療機器研究　15　2010

    ISSN： 0918-435X

  112. ポジトロン断層法とC-11標識二酸化炭素を用いた果実への炭素動態の三次元PETイメージング

    河地有木, 鈴井伸郎, 石井里美, 伊藤小百合, 石岡典子, 藤巻秀, 菊地郁, 渡部浩司

    アイソトープ・放射線研究発表会要旨集　47th　2010

  113. Evaluation of cerebral astrocyte specific energy metabolism in normal human volunteers by [C-11]acetate and PET.

    Hiroshi Watabe, Toshiko Ishikawa, Yuka Matsuo, Yasukazu Kanai, Masao Imaizumi, Hiroki Katoh, Eku Shimosegawa, Jun Hatazawa

    NeuroImage　52　(Supplement-1)　S149-150　2010

    DOI： 10.1016/j.neuroimage.2010.04.123 　

    ISSN： 1053-8119

  114. Quantitative assessment of density and affinity for dopamine D-2 receptors with multiple injections of [C-11]raclopride

    Y. Ikoma, H. Watabe, T. Hayashi, K. Minato, H. Iida

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　29　S348-S349　2009/10

    ISSN： 0271-678X

  115. QBASE: image database system for multicenter clinical studies with QSPECT package

    H. Watabe, T. Hayashi, T. Akamatsu, H. Iida

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　29　S589-S590　2009/10

    ISSN： 0271-678X

  116. 頭部用局所高解像度定量SPECT装置の開発

    銭谷勉, 平野祥之, 崎本智則, 石田健二, 渡部浩司, 寺本昇, 工藤博幸, 湊小太郎, 畑澤順, 飯田秀博

    核医学　46　(3)　S226　2009/09/30

    ISSN： 0022-7854

  117. 解像度補正および吸収・散乱補正SPECT定量画像再構成法の開発と頭部撮像のための評価

    崎本智則, 銭谷勉, 石田健二, 平野祥之, SOHLBERG Antti, 渡部浩司, 湊小太郎, 飯田秀博

    核医学　46　(3)　S226　2009/09/30

    ISSN： 0022-7854

  118. SPECT検査の精度向上と施設間誤差のない標準的画像診断法の確立

    飯田秀博, 渡部浩司, 中澤真弓, 赤松哲也, 越野一博, 寺本昇, 銭谷勉, 林拓也, 平野祥之, 圓見純一郎, 三宅義徳, 合瀬恭幸, 樋掛正明, 山本明秀, 岩西雄大, 山内美穂, 松原佳亮, 岩田倫明, 石田健二, 能勢直子, 福田肇

    新しい医療機器研究　14　93-94　2009/03/25

    ISSN： 0918-435X

  119. PET装置ならびに関連技術の進歩

    Koshino K, Hirano Y, Teramoto N, Watabe H, Iida H

    PET journal　5　21-23　2009/03

  120. PETを用いた多施設共同臨床試験によるアルツハイマー病の超早期診断法の確立と普及 簡易定量法の開発を目的としたBF-227の生体内動態解析

    田代学, 岡村信行, 熊谷和明, 古本祥三, 古川勝敏, 藁谷正明, 船木善仁, 四月朔日聖一, 三宅正泰, 岩田錬, 工藤幸司, 荒井啓行, 木村裕一, 渡部浩司, 谷内一彦

    PETを用いた多施設共同臨床試験によるアルツハイマー病の超早期診断法の確立と普及 平成20年度 総括研究報告書 総合研究報告書　2009

  121. RI分子標的診断を可能にする高解像度SPECT撮像装置の開発

    銭谷勉, 平野祥之, 崎本智則, 石田健二, 渡部浩司, 寺本昇, 湊小太郎, 飯田秀博

    日本生体医工学会大会プログラム・論文集(CD-ROM)　48th　ROMBUNNO.OS-20-1　2009

  122. 小視野検出器を利用した臨床用局所高解像度定量SPECTの検討

    銭谷勉, 渡部浩司, 工藤博幸, 平野祥之, 湊小太郎, 飯田秀博

    核医学　45　(3)　S187　2008/09/30

    ISSN： 0022-7854

  123. 小視野高解像度検出器と大視野低解像度検出器を組み合わせた局所高解像度定量SPECTの検討

    銭谷勉, 渡部浩司, 工藤博幸, 平野祥之, 湊小太郎, 飯田秀博

    核医学　45　(3)　S187　2008/09/30

    ISSN： 0022-7854

  124. 正常ラットにおける[123I]INMU体内分布

    三宅義徳, 渡部浩司, 銭谷勉, 会瀬恭幸, 大田洋一郎, 林拓也, 石田良雄, 飯田秀博

    核医学　45　(3)　S193　2008/09/30

    ISSN： 0022-7854

  125. SPECT画像再構成・画像処理の標準化とその評価に関する研究

    飯田 秀博, 渡部 浩司, 銭谷 勉, 中川原 譲二, 丸野 廣大, 橋川 一雄, 松田 博史, 石田 良雄, 福島 和人, 黒川 徹, 鈴木 倫保, 畑澤 順, 山田 省吾, 中島 孝, 宮本 享, 中澤 真弓, 赤松 哲也

    核医学 : 日本核医学会機関誌 : the Japanese journal of nuclear medicine　45　(3)　232-232　2008/09/30

    ISSN： 0022-7854

  126. リストモードデータを用いたRIトレーサの時空間動態表示

    黒田知宏, 谷本達昭, 渡部浩司, 黒田嘉宏, 大城理

    日本医用画像工学会大会予稿集(CD-ROM)　27th　(Suppl.)　ROMBUNNO.C5-02-02　2008/08

    Publisher: 日本医用画像工学会

    ISSN： 0288-450X

  127. Standardization of Rest-Diamox CBF Assessment using SPECT-Value for a Multi-Center Study

    IIDA HIDEHIRO, WATABE HIROSHI, AKAMATSU TETSUYA, NAKAZAWA MAYUMI, MATSUBARA KEISUKE, TAKEUCHI ASAKO, IWATA MICHIAKI, HAYASHI TAKUYA, YAMAMOTO AKIHIDE, MIYAMOTO SUSUMU, IIHARA KOJI, YOKOTA CHIAKI, MORIWAKI HIROSHI, FUKUSHIMA KAZUTO, FUKUMOTO SHINJI

    脳循環代謝　19　(3)　110-119　2008/04/30

    ISSN： 0915-9401

  128. SPECT検査の精度向上と施設間誤差のない標準的画像診断法の確立

    飯田秀博, 渡部浩司, 中澤真弓, 赤松哲也, 越野一博, 寺本昇, 銭谷勉, 林拓也, 圓見純一郎, 三宅義徳, 大田洋一郎, 猪股亨, 合瀬恭幸, 朴日淑, 樋掛正明, 山本明秀, 岩西雄大, 山内美穂, 松原佳亮, 岩田倫明, 石田健二, 福田肇, 崔洪海, 佐藤博司

    新しい医療機器研究　13　117　2008/03/15

    ISSN： 0918-435X

  129. MRIと核医学手法の正確な重ね合わせ技術に基づく癌の新しい分子イメージング診断法

    飯田秀博, 佐藤博司, 渡部浩司, 越野一博, 寺本昇, 銭谷勉, 林拓也, 圓見純一郎, 三宅義徳, 大田洋一郎, 猪股亨, 合瀬恭幸, 朴日淑, 樋掛正明, 山本明秀, 岩西雄大, 山内美穂, 松原佳亮, 岩田倫明, 石田健二, 福田肇, 崔洪海, 後藤隆男, 岩舘雄二, 塚元鉄二

    新しい医療機器研究　13　62-63　2008/03/15

    ISSN： 0918-435X

  130. リストモードデータの時空間解析によるRIトレーサの可視化

    谷本達昭, 渡部浩司, 黒田嘉宏, 黒田知宏, 大城理

    日本生体医工学会大会プログラム・論文集(CD-ROM)　47th　ROMBUNNO.PS1-4-18　2008

  131. 細胞組織工学的手法を用いた中枢神経障害に対する根治的治療法の開発 霊長類を用いた検討に関する研究

    飯田秀博, 銭谷勉, 林拓也, 渡部浩司, 猪股亨

    細胞組織工学的手法を用いた中枢神経障害に対する根治的治療法の開発 平成19年度 総括・分担研究報告書　38-49　2008

  132. 小動物用ピンホールSPECTの高感度化

    猪股亨, SOHLBERG Antti, 合瀬恭幸, 銭谷勉, 渡部浩司, 寺本昇, 飯田秀博

    核医学　44　(3)　314-315　2007/10/30

    ISSN： 0022-7854

  133. ピンボールSPECTにおけるトランケーションデータからの3D‐OSEM画像再構成

    銭谷勉, 渡部浩司, SOHLBERG Antti, 猪股亨, 工藤博幸, 飯田秀博

    核医学　44　(3)　317　2007/10/30

    ISSN： 0022-7854

  134. ニューロメジンの123I標識化

    大田洋一郎, 三宅義徳, 銭谷勉, 寺本昇, 合瀬恭幸, 黒川麻紀, 渡部浩司, 飯田秀博

    核医学　44　(3)　289　2007/10/30

    ISSN： 0022-7854

  135. ピンホールSPECTと123I‐IMPを用いたマウス局所脳血流定量測定

    銭谷勉, 渡部浩司, 林拓也, 合瀬恭幸, 明神和紀, 田口明彦, 寺本昇, 猪股亨, 山道芳弘, 飯田秀博

    核医学　44　(3)　277　2007/10/30

    ISSN： 0022-7854

  136. 小動物用核医学機器の最近の進歩

    渡部 浩司

    核医学　44　(3)　S147　2007/10/30

    ISSN： 0022-7854

  137. Extraction of RI-Tracer Dynamics from List-Mode Data

    TANIMOTO Michiaki, WATABE Hiroshi, KURODA Yoshihiro, KURODA Tomohiro, OSHIRO Osamu

    IEICE technical report　107　(248)　39-42　2007/10/04

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    The list-mode data in the PET (Positron Emission Tomography) study contains time and space information, and is used for the estimation of physiologic parameters, and RI (Radio Isotope)-tracer dynamics. In this paper, RI-tracer dynamics has been extracted applying density-based clustering to simulated and measured data. As the result, barycentric trajectory corresponding to RI-tracer dynamics could be confirmed.

  138. Flow Analysis System for Leukocyte Removal Column

    ONODERA Hirokazu, WATABE Hiroshi, MINATO Kotaro, IIDA Hidehiro

    Medical Imaging Technology　25　(4)　277-283　2007/09/25

    Publisher: The Japanese Society of Medical Imaging Technology

    DOI： 10.11409/mit.25.277 　

    ISSN： 0288-450X

  139. 130 ^<13>N-NH_3とPET/CTによる定量評価のための解析パラメータの比較と検討(核医学検査PET2, 第35回日本放射線技術学会秋季学術大会プログラム)

    宍戸 博紀, 渡部 浩司, 森田 浩一, 玉木 長良, 廣川 裕, 大塚 信昭

    日本放射線技術學會雜誌　63　(9)　1020-1020　2007/09/20

    Publisher: 公益社団法人日本放射線技術学会

    ISSN： 0369-4305

  140. MRIと核医学手法の正確な重ね合わせ技術に基づく癌の新しい分子イメージング診断法

    飯田秀博, 佐藤博司, 渡部浩司, 越野一博, 寺本昇, 銭谷勉, 林拓也, 圓見純一郎, 三宅義徳, 大田洋一郎, 猪股亨, 合瀬恭幸, 朴日淑, 樋掛正明, 山本明秀, 岩西雄大, 山内美穂, 黒川麻紀, 後藤隆男, 岩舘雄二, 塚元鉄二

    新しい医療機器研究　12　49-51　2007/03/25

    ISSN： 0918-435X

  141. Development of a multi-modality registration system for the medical image by USB camera

    IWATA Michiaki, KOSHINO Kazuhiro, YAMAMOTO Akihide, SATO Hiroshi, WATABE Hiroshi, IIDA Hidehiro, MINATO Kotaro

    IEICE technical report　106　(509)　35-38　2007/01/19

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    Recently, many techniques related to medical imaging such as X-ray CT, PET, SPECT and MRI have been introduced and especially multimodal imaging has been investigated by several researches. Our aim of this study is to develop a simple and cost-effective multimodal registration system using commercially available USB cameras. Two USB cameras are utilized to obtain three dimensional position and orientation of a patient while scanning by an image modality such as PET and MRI. By our system, two images obtained by different modalities can be automatically registered.

  142. 心エコー診断法との比較による15O-CO PET心プール・ゲートおよび18F-FDG PETゲート解析の有用性の検討

    寺本昇, 越野一博, 合瀬恭幸, 樋掛正明, 大田洋一郎, 林拓也, 渡部浩司, 飯田秀博

    核医学　44　(3)　2007

    ISSN： 0022-7854

  143. 細胞組織工学的手法を用いた中枢神経障害に対する根治的治療法の開発 霊長類を用いた検討に関する研究

    飯田秀博, 銭谷勉, 林拓也, 渡部浩司, 猪股亨

    細胞組織工学的手法を用いた中枢神経障害に対する根治的治療法の開発 平成18年度 総括研究報告書　65-79　2007

  144. 癌診断における PET/SPECT 技術

    渡部浩司

    実験医学増刊号　2007

  145. 小動物イメージング最近の動向

    渡部 浩司, 寺本 昇, 合瀬 恭幸, 銭谷 勉

    臨床放射線　52　(9)　1108-1113　2007

    Publisher: 金原出版

    ISSN： 0009-9252

  146. The validity and value of a quantitative SPECT reconstruction package (QSPECT) for evaluating multi-center clinical trials

    Hidehiro Iida, Hiroshi Watabe, Tetsuya Akamatsu, Mayumi Nakazawa, Keisuke Matsubara, Asako Takeuchi, Michiaki Iwata, Takuya Hayashi, Chiaki Yokota, Kazuto Fukushima, Shinji Fukumoto

    Japanese Journal of Neurosurgery　16　(10)　742-752　2007

    Publisher: Japanese Congress of Neurological Surgeons

    DOI： 10.7887/jcns.16.742 　

    ISSN： 0917-950X

  147. PETによる脳・心臓循環代謝イメージング

    越野 一博, 渡部 浩司, 飯田 秀博

    クリニカルプラクティス　2007

  148. 小動物用ピンホールSPECTシステムの開発

    猪股亨, ANTTI Sohlberg, 合瀬恭幸, 銭谷勉, 渡部浩司, 寺本昇, 岳野猛, 飯田秀博

    核医学　43　(3)　244　2006/10/30

    ISSN： 0022-7854

  149. モンテカルロシミュレーションコードGATEを用いたピンホールSPECTカメラの最適化

    渡部浩司, 久保敦子, 銭谷勉, 宍戸博紀, 飯田秀博

    核医学　43　(3)　239　2006/10/30

    ISSN： 0022-7854

  150. 小視野ピンホールSPECTを用いた心筋画像定量におけるトランケーションの影響

    銭谷勉, 渡部浩司, 猪股亨, ANTTI Sohlberg, 飯田秀博

    核医学　43　(3)　226　2006/10/30

    ISSN： 0022-7854

  151. 510 3次元18F-FDG PET/CT収集における視野外散乱線の低減化に関するGATEを用いた吸収体の検討(核医学検査 PET定量,一般研究発表,日本放射線技術学会 第34回秋季学術大会)

    宍戸 博紀, 富永 隆宏, 大倉 保彦, 大塚 信昭, 渡部 浩司

    日本放射線技術學會雜誌　62　(9)　1312-1312　2006/09/20

    Publisher: 公益社団法人日本放射線技術学会

    ISSN： 0369-4305

  152. Development of porcine model for old myocardial infarction and assessment system for therapeutic trials of myocardial regeneration medicine using positron emission tomography (PET)

    TERAMOTO Noboru, WATABE Hiroshi, IIDA Hidehiro

    55　(3)　182-182　2006/04/01

    ISSN： 1341-1357

  153. MRIと核医学手法の正確な重ね合わせ技術に基づく癌の新しい分子イメージング診断法

    飯田秀博, 佐藤博司, 渡部浩司, 越野一博, 寺本昇, 銭谷勉, 林拓也, 円見純一郎, 三宅義徳, 大田洋一郎, 久冨信之, 猪股亨, 合瀬恭幸, 朴日淑, 樋掛正明, 山本明秀, 山内美穂, 岳野猛, 田原賢吾

    新しい医療機器研究　11　26-27　2006/03/25

    ISSN： 0918-435X

  154. 新たな治療体系の創造と改革 創薬・再生医療につながる生体分子イメージング (特集 最先端医療技術が拓く未来)

    飯田 秀博, 三宅 義徳, 渡部 浩司

    月刊新医療　33　(3)　113-116　2006/03

    Publisher: エム・イー振興協会 ; 1975-

    ISSN： 0910-7991

  155. Simplified reference tissue approach with multiple injections of [C-11]raclopride

    Hiroshi Watabe, Y. Ohta, N. Teramoto, Y. Miyake, M. Kurokawa, A. Yamamoto, Y. Ose, T. Hayashi, H. Iida

    NEUROIMAGE　31　T72-T72　2006

    DOI： 10.1016/j.neuroimage.2006.04.062 　

    ISSN： 1053-8119

  156. A novel reference tissue approach for multiple injections of [C-11]raclopride

    Hiroshi Watabe, Y. Ohta, N. Teramoto, Y. Miyake, M. Kurokawa, A. Yamamoto Y. Ose, T. Hayashi, H. Iida

    NEUROIMAGE　31　T73-T73　2006

    DOI： 10.1016/j.neuroimage.2006.04.063 　

    ISSN： 1053-8119

  157. PET用持続動脈血液中放射能濃度測定器を用いた脳血流量の評価－Phoswich型, 同時計数型およびプラスチックシンチレータ型の比較－

    松本圭一, 渡部浩司, 山本誠一, 坂本攝, 飯田秀博, 村瀬研也, 千田道雄

    核医学技術　26　(3)　194-203　2006

  158. PET/SPECT 分子イメージング研究の展望

    飯田 秀博, 渡部 浩司, の

    INNERVISION　2006

  159. 病態生理からみた心筋 viability

    飯田 秀博, 寺本 昇, 越野 一博, 大田 洋一郎, 渡部 浩司, の

    臨床放射線　2006

  160. 創薬・再生医療につながる生体分子イメージング

    飯田 秀博, 渡部 浩司, 三宅 義徳, 大田 洋一郎, 寺本 昇

    新 医 療　2006

  161. 分子イメージング

    渡部 浩司, 飯田 秀博

    Ｃａｒｄｉａｃ Practice　61-66　2006

    Publisher: 北隆館

  162. ピンホールSPECTにおける2軌道完全データ収集法のシミュレーションによる評価

    銭谷勉, 渡部浩司, 青井利行, 久保敦子, 飯田秀博

    核医学　42　(3)　351　2005/09/20

    ISSN： 0022-7854

  163. 高解像度ピンホールSPECTによるマウス大腿骨髄イメージング

    銭谷勉, 若杉茂俊, 加奈川優, 久保敦子, 渡部浩司, 飯田秀博

    核医学　42　(3)　350　2005/09/20

    ISSN： 0022-7854

  164. PET分子イメージングによる創薬支援システムの構築にむけて

    飯田秀博, 林拓也, 渡部浩司, 寺本昇, 越野一博, 円見純一郎, 佐藤博司, 久冨信之, 銭谷勉, KIM K.‐M, 猪股亨, PIAO R, 大田洋一郎, 太田稔宏, 山内美穂, 合瀬恭幸, 赤松哲哉, 山本明秀, 小野寺博和, 栗栖麗, 樋掛正明

    日本ME学会大会論文集　44th　97　2005/04/25

  165. Brain imaging for psychiatric disorders. Real-time motion correction system for head.

    飯田秀博, 渡部浩司, 越野一博, 久冨信之, 林拓也

    精神疾患における脳の画像解析学的研究 平成14-16年度 総括研究報告書　2005

  166. Basis Function法を用いた[O-15]水PETによる心筋血流量イメージング-自動化の試み

    渡部浩司, 越野一博, 寺本昇, 大田洋一郎, 林拓也, 飯田秀博

    核医学　42　(3)　2005

    ISSN： 0022-7854

  167. ブタ慢性心筋梗塞モデルにおけるH2 15O PETを用いた冠血管予備能の検討

    寺本昇, 越野一博, 大田洋一郎, 久冨信之, 林拓也, 渡部浩司, 横山郁夫, 横山郁夫, 飯田秀博

    核医学　42　(3)　2005

    ISSN： 0022-7854

  168. 急性脳虚血時の酸素供給低下に対する代償機能-サル脳塞栓モデルでの15O-PETによる検討

    朴日淑, 林拓也, 寺本昇, 久冨信之, 大田洋一郎, 越野一博, 渡部浩司, 飯田秀博

    核医学　42　(3)　2005

    ISSN： 0022-7854

  169. Brain imaging for psychiatric disorders. Statistical analysis of PET list mode data using Bootstrap method.

    飯田秀博, 渡部浩司, 越野一博, 久冨信之, 林拓也

    精神疾患における脳の画像解析学的研究 平成14-16年度 総括研究報告書　2005

  170. 15O-H2O PET心筋血流量解析のための医用画像処理ソフトウェアの開発

    越野一博, 渡部浩司, 河地有木, 林拓也, 長谷川新治, 畑沢順, 飯田秀博

    核医学　42　(3)　2005

    ISSN： 0022-7854

  171. 完全データを利用したピンホールSPECT

    銭谷 努, 渡部 浩司, 工藤 博幸, 飯田 秀博

    Medical Imaging Technology　23　(1)　9-16　2005

    Publisher: The Japanese Society of Medical Imaging Technology

    DOI： 10.11409/mit.23.9 　

    ISSN： 0288-450X

  172. 画像重ね合わせ手法の概要と実例 (特集1 融合画像の現在とこれから) -- (融合画像作成における工学的役割)

    越野 一博, 渡部 浩司, 飯田 秀博

    映像情報medical　36　(12)　1342-1347,1294　2004/11

    Publisher: 産業開発機構

    ISSN： 1346-1354

  173. 並列コンピュータを用いたピンホールSPECT画像再構成の高速化

    銭谷勉, 渡部浩司, 飯田秀博

    核医学　41　(3)　387　2004/09/20

    ISSN： 0022-7854

  174. Tl‐201ブタSPECTにおけるコントロールおよび薬物負荷中の心筋血流定量のための短時間検査法

    キム キョンミン, 神尾弘, 寺本昇, 渡部浩司, 林拓也, 大田洋一郎, 久冨信之, 河地有木, 銭谷勉

    核医学　41　(3)　327　2004/09/20

    ISSN： 0022-7854

  175. 小型ガンマカメラを用いた小動物用ピンホールSPECT装置の開発

    銭谷勉, 渡部浩司, 青井利行, 岳野猛, KIM K M, 寺本昇, 大田洋一郎, 林拓也, 飯田秀博

    核医学　41　(3)　372　2004/09/20

    ISSN： 0022-7854

  176. Long-term effect of motor cortical repetitive transcranial magnetic stimulation induces. (vol 56, pg 77, 2004)

    T Hayashi, T Ohnishi, S Okabe, N Teramoto, Y Nonaka, H Watabe, E Imabayashi, Y Ohta, H Jino, N Ejima, T Sawada, H Iida, H Matsuda, Y Ugawa

    ANNALS OF NEUROLOGY　56　(2)　311-311　2004/08

    DOI： 10.1002/ana.20245 　

    ISSN： 0364-5134

  177. Validity and impact of a quantitative SPECT reconstruction package (QSPECT) in clinical dynamic SPECT

    H Iida, KM Kim, T Akamatsu, H Watabe

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　31　S260-S261　2004/08

    ISSN： 1619-7070

  178. Impact of image-based scatter correction for (IMP)-I-123-SPECT and SPM analysis

    M Shidahara, H Watabe, KM Kim, T Kato, S Kawatsu, R Kato, K Yoshimura, H Iida, K Ito

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　31　S402-S402　2004/08

    ISSN： 1619-7070

  179. Fusion Imaging Advances 形態画像と機能画像の統合の現状と展望 1.画像重ね合わせ手法の理論と基礎

    越野一博, 渡部浩司, 飯田秀博

    Innervision　19　(2)　2004

    ISSN： 0913-8919

  180. I-123 IMP SPECTにおける短時間・薬物負荷脳血流定量法の評価

    キム キョンミン, 林拓也, 林田孝平, 片淵哲朗, 榎本直之, 河地有木, 渡部浩司, 石田良雄, 飯田秀博

    核医学　41　(3)　2004

    ISSN： 0022-7854

  181. Basis Function法を用いた[O-15]水PETによる心筋血流量イメージング

    渡部浩司, 神尾弘, 河地有木, 寺本昇, 林拓也, 飯田秀博

    核医学　41　(3)　2004

    ISSN： 0022-7854

  182. H215O PET心筋血流量定量におけるBootstrap法を用いた統計解析

    河地有木, 渡部浩司, 寺元昇, 大田洋一郎, 神尾弘, 久冨信之, 越野一博, KIM K M, 林拓也

    核医学　41　(3)　2004

    ISSN： 0022-7854

  183. 15O-H2O PETによる心筋血流量定量検査における体動補正システムの開発

    越野一博, 河地有木, 林拓也, 渡部浩司, 長谷川新治, 畑沢順, 飯田秀博

    核医学　41　(3)　2004

    ISSN： 0022-7854

  184. Quantitative assessment of myocardial blood flow induced by adenosine and CGS-21680 with (H2OPET)-O-15 in miniature pigs

    H Jino, N Teramoto, N Kawachi, Y Ohta, N Kudomi, T Hayashi, H Watabe, Yokoyama, I, H Iida

    JOURNAL OF PHARMACOLOGICAL SCIENCES　94　274P-274P　2004

    ISSN： 1347-8613

  185. 169 超偏極キセノンを応用したMRシステムの開発(JIRA発表 技術-3)

    佐藤 博司, 竹井 直行, 岩舘 雄治, 阿部 清子, 塚元 鉄二, 永澤 清, 圓見 純一郎, 寺本 昇, 河地 有木, 渡部 浩司, 林 拓也, 飯田 秀博, 澤田 徹

    日本放射線技術學會雜誌　59　(9)　1065-1065　2003/09/20

    Publisher: 公益社団法人日本放射線技術学会

    DOI： 10.6009/jjrt.KJ00000922039 　

    ISSN： 0369-4305

  186. PETによる迅速脳血流・酸素代謝定量法の検討―サルによる従来法との比較

    久冨信之, 林拓也, 寺本昇, 渡部浩司, 金敬文, 大田洋一郎, 河地有木, 神尾弘, 銭谷勉

    核医学　40　(3)　350　2003/08/20

    ISSN： 0022-7854

  187. PET酸素代謝量の定量測定のためのサルを使った代謝循環水推定法の評価

    久冨信之, 林拓也, 寺本昇, 渡部浩司, 大田洋一郎, 河地有木, 神尾弘, 銭谷勉, 金敬文

    核医学　40　(3)　349-350　2003/08/20

    ISSN： 0022-7854

  188. 完全データを利用したピンホールSPECT画像再構成

    銭谷勉, 渡部浩司, 青井利行, KIM K M, 寺本昇, 林拓也, SOHLBERG A, 工藤博幸, 飯田秀博

    核医学　40　(3)　343　2003/08/20

    ISSN： 0022-7854

  189. Factor analysis for extracting tissue component in O-15(2) gas PET study.

    KM Kim, H Watabe, N Kudomi, T Hayashi, JS Lee, K Hayashida, H Iida

    JOURNAL OF NUCLEAR MEDICINE　44　(5)　251P-251P　2003/05

    ISSN： 0161-5505

  190. [18F]FDG accumulation to the atherosclerotic vulnerable plaque: Correlation with infiltrated macrophage number.

    M Ogawa, T Mukai, S Ishino, D Asano, N Teramoto, H Watabe, N Kudomi, M Shiomi, Y Magata, H Iida, H Saji

    JOURNAL OF NUCLEAR MEDICINE　44　(5)　189P-190P　2003/05

    ISSN： 0161-5505

  191. Impact of image-based scatter correction for IMP-SPECT and SPM analysis.

    M Shidahara, H Watabe, K Kim, T Kato, S Kawatsu, R Kato, K Hatano, H Iida, K Ito

    JOURNAL OF NUCLEAR MEDICINE　44　(5)　263P-263P　2003/05

    ISSN： 0161-5505

  192. 静脈内注射用O‐15標識O2製剤の開発とそれを用いたラット脳局所酸素摂取率の測定

    天満敬, 間賀田泰寛, 飯田秀博, 小川美香子, 向高弘, 渡部浩司, 森本隆之, 北野治広, 佐治英郎

    日本薬学会年会要旨集　123rd　(3)　69　2003/03/05

    ISSN： 0918-9823

  193. 3種類のPET用持続動脈血液中放射能濃度測定器を用いた脳血流量の評価

    松本圭一, 松浦元, 坂本摂, 中本裕士, 河嶋秀和, 山本誠一, 渡部浩司, 飯田秀博, 志田原美保

    核医学　40　(3)　2003

    ISSN： 0022-7854

  194. 15O水-PETによる心筋血流量の定量測定における体動補正の効果

    越野一博, 河地有木, 渡部浩司, 長谷川新治, 畑沢順, 飯田秀博

    核医学　40　(3)　2003

    ISSN： 0022-7854

  195. H215O-PETによるadenosine及びCGS-21680誘発ミニブタ心筋血流量の定量的測定

    神尾弘, 河地有木, 寺本昇, 大田洋一郎, 久冨信之, 林拓也, 渡部浩司, 横山郁夫, 飯田秀博

    核医学　40　(3)　2003

    ISSN： 0022-7854

  196. O-15標識水PET検査における局所心筋血流定量化の精度向上

    河地有木, 渡部浩司, 神尾弘, 久冨信之, KIM K M, 林拓也, 飯田秀博

    核医学　40　(3)　2003

    ISSN： 0022-7854

  197. PETリストモード収集と光学式トラッキング装置を用いた頭部PET検査における動き補正法の開発

    渡部浩司, WOO S-K, KIM K-M, 河地有木, 久冨信之, 松浦元, 松本圭一, 林拓也, 飯田秀博

    核医学　40　(3)　2003

    ISSN： 0022-7854

  198. PETによる迅速脳血流・酸素代謝定量法の検討―シュミレーションによる評価およびサルによる従来法との比較

    久冨信之, 林拓也, 寺本昇, 渡部浩司, 大田洋一郎, 河地有木, 神尾弘, 銭谷勉, 金敬王分

    日本脳循環代謝学会総会プログラム・抄録集　15th　116　2003

  199. マルチモダリティの画像位置合わせと重ね合わせ

    渡部浩司

    日本放射線技術学会誌　59　(1)　60-65　2003

    DOI： 10.6009/jjrt.KJ00000921595 　

  200. リガンド受容体結合はいかにして解析するか

    渡部浩司

    ＰＥＴ通信　2003

  201. 神経受容体解析入門

    渡部 浩司

    核医学　39　(3)　278-278　2002/09/20

    ISSN： 0022-7854

  202. 静脈内注射用O‐15標識O2製剤の開発とそれを用いたラット脳局所酸素摂取率の測定

    天満敬, 間賀田泰寛, 飯田秀博, 小川美香子, 向高弘, 渡部浩司, 森本隆之, 小西淳二, 佐治英郎

    核医学　39　(3)　400　2002/09/20

    ISSN： 0022-7854

  203. [18F]FDGによる不安定プラーク検出の試み

    小川美香子, 石野誠悟, 向高弘, 寺本昇, 久冨信之, 渡部浩司, 飯田秀博, 佐治英郎

    核医学　39　(3)　364　2002/09/20

    ISSN： 0022-7854

  204. Non-invasive extraction of blood component using non-negative matrix factorization in dynamic N-13 ammonia cardiac PET studies.

    KM Kim, H Watabe, K Fukuchi, H Oka, N Kudomi, Y Ishida, H Iida

    JOURNAL OF NUCLEAR MEDICINE　43　(5)　144P-145P　2002/05

    ISSN： 0161-5505

  205. Evaluation of accuracy of motion correction with optical motion tracking system and PET.

    H Watabe, E Choi, N Sato, H Iida

    JOURNAL OF NUCLEAR MEDICINE　43　(5)　208P-208P　2002/05

    ISSN： 0161-5505

  206. Evaluation of penetration and scattering effects in pinhole SPECT using Monte Carlo simulation.

    HM Deloar, H Watabe, T Aoi, H Iida

    JOURNAL OF NUCLEAR MEDICINE　43　(5)　219P-219P　2002/05

    ISSN： 0161-5505

  207. Development and application of a GSO detector assembly for a continuous blood sampling system.

    N Kudomi, E Choi, H Watabe, KM Kim, M Shidahara, M Ogawa, N Teramoto, E Sakamoto, S Yamamoto, H Iida

    JOURNAL OF NUCLEAR MEDICINE　43　(5)　229P-229P　2002/05

    ISSN： 0161-5505

  208. Utilization of dynamic sinogram using ECAT EXACT and 15O-labeled compounds for accurate rCBF, rOEF and rCMRO2.

    M Shidahara, H Watabe, K Hayashida, K Kim, T Nakamura, T Kato, K Ito, H Iida

    JOURNAL OF NUCLEAR MEDICINE　43　(5)　207P-208P　2002/05

    ISSN： 0161-5505

  209. Does cerebral perfusion reserve reflect oxgen extraction fraction? - Analysis on intensity-filtered VOI method.

    T Hayashi, H Watabe, H Moriwaki, Y Hasegawa, J Takahashi, K Fukuchi, K Hayashida, H Iida

    JOURNAL OF NUCLEAR MEDICINE　43　(5)　245P-245P　2002/05

    ISSN： 0161-5505

  210. Optimal scan time of O-15-labeled gas inhalation method for measurement of cerebral oxygen extraction fraction.

    M Shidahara, H Watabe, K Kim, T Nakamura, T Kato, K Ito, H Iida

    JOURNAL OF NUCLEAR MEDICINE　43　(5)　211P-211P　2002/05

    ISSN： 0161-5505

  211. Noise property of two CMRO2 quantitation methods with a short bolus inhalation of O-15(2).

    N Kudomi, H Watabe, Y Miyake, KM Kim, M Shidahara, K Hayashida, N Oka, M Sagou, Y Ishida, T Hayahsi, H Iida

    JOURNAL OF NUCLEAR MEDICINE　43　(5)　211P-211P　2002/05

    ISSN： 0161-5505

  212. Development of motion correction technique for brain PET with optical motion tracking system and listmode acquisition.

    H Watabe, N Sato, E Choi, P Bloomfield, H Iida

    JOURNAL OF NUCLEAR MEDICINE　43　(5)　204P-205P　2002/05

    ISSN： 0161-5505

  213. 前頭葉損傷と後方領域損傷の失語症患者における単語想起課題の賦活試験 急性期からの検討

    大槻 美佳, 小村 江美, 森脇 博, 宮下 光太郎, 山脇 健盛, 成冨 博章, 林田 孝平, 山田 直明, 渡部 浩司, 飯田 秀博

    臨床神経学　41　(11)　936-936　2001/11

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

    eISSN： 1882-0654

  214. RI検査技術における将来展望

    飯田 秀博, 渡部 浩司, 片渕 哲朗

    核医学分科会誌　0　(43)　19-21　2001/11/01

    Publisher: 公益社団法人日本放射線技術学会

    ISSN： 1345-3203

  215. PET : 血流イメージングの現状と将来

    飯田 秀博, 渡部 浩司, 久富 信之

    BME : bio medical engineering　15　(8)　13-19　2001/08/10

    Publisher: Japanese Society for Medical and Biological Engineering

    DOI： 10.11239/jsmbe1987.15.8_13 　

    ISSN： 0913-7556

  216. Contribution of scatter correction in the kinetic analysis of a D2 receptor ligand with SPECT.

    KM Kim, H Watabe, M Shidahara, Y Onishi, Y Yonekura, H Iida

    JOURNAL OF NUCLEAR MEDICINE　42　(5)　217P-217P　2001/05

    ISSN： 0161-5505

  217. Effect of scatter correction on quantitative estimation in receptor ligand study with SPECT.

    KM Kim, H Watabe, M Shidahara, A Varrone, M Fujita, RB Innis, H Iida

    JOURNAL OF NUCLEAR MEDICINE　42　(5)　184P-184P　2001/05

    ISSN： 0161-5505

  218. Validation of shortening scan intervals in repeat measurement of cerebral blood flow with O-15 water and PET.

    H Watabe, Y Kondoh, KM Kim, M Shidahara, H Iida

    JOURNAL OF NUCLEAR MEDICINE　42　(5)　220P-220P　2001/05

    ISSN： 0161-5505

  219. A Tool for The Diagnosis of Constrictive Pericaditis Using MR Tagged Cine Imaging

    Kinoshita Hirotsugu, Urayama Shin-ichi, Yamada Naoaki, Watabe Hiroshi, Motooka Makoto, Hirane Yoshihisa, Iida Hidehiro

    IEICE technical report.　100　(596)　39-44　2001/01/18

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    Constrictive Pericarditis(CP) is characterized by thickening or adhesion of pericardium that results in restriction of the shear movement between epicardium and pericardium. Diagnosis of CP has been based on abnormality of pericardial morphology or right ventricular pressure. However, these abnormalities are indirect proofs of CP because they don&#039;t clarify restricted myocardial motion. The purpose of this study is to develop a tool for diagnosis of CP using MR tagging imaging which can assess the restriction directly. Analyzed data sets show clear difference between a normal volunteer and a...

  220. Evaluation of Tag Detection Errors with Simulated MR-Tagging Images : Error evaluation of Detected Tag Positions with Precise Tag-Detection Algorithms Using Simulated Stripe-Tag Images

    Kinoshita Hirotsugu, Urayama Shin-ichi, Yamada Naoaki, Watabe Hiroshi, Hirane Yoshihisa, Iida Hidehiro

    IEICE technical report.　100　(464)　1-6　2000/11/07

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    For analysis of myocardial kinetic function using tagging images, evaluated values such as regional myocardial strain are seriously effected by tag detection errors. This paper describes the evaluation of tag detection errors with Harmonic-Phase(HARP)and Gaussian-Fitting algorithm using simulated MR-tagging images. Gaussian-Fitting algorithm with low-pass filter smoothing was revealed to be useful to detect smooth tag lines with little errors(average error &amp;It; 0.16 pixels, maximum error &amp;It; 0.90 pixels).

  221. 脳神経核医学 : SPMを中心に

    宮下 光太郎, 橋川 一雄, 渡部 浩司, 大西 隆

    核医学　37　(5)　442-443　2000/09/20

    ISSN： 0022-7854

  222. Optimization and validation for quantitative brain perfusion imaging using Tc-99m ethyle cycteinate dimmer (ECD) and SPECT.

    H Iida, M Shidahara, H Watabe, K Kitamura, KM Kim, T Hachiya

    JOURNAL OF NUCLEAR MEDICINE　41　(5)　185P-185P　2000/05

    ISSN： 0161-5505

  223. Measurement of dopamine release with [C-11]raclopride and continuous infusion: Optimization and signal-to-nose considerations.

    H Watabe, CJ Endres, RE Carson

    JOURNAL OF NUCLEAR MEDICINE　39　(5)　55P-55P　1998/05

    ISSN： 0161-5505

  224. Evaluation of a new F-18 labeled analog of the 5-HT1A antagonist way 100635 for PET.

    RE Carson, L Lang, H Watabe, MG Der, HR Adams, E Jagoda, CJ Endres, P Herscovitch, WC Eckelman

    JOURNAL OF NUCLEAR MEDICINE　39　(5)　135P-136P　1998/05

    ISSN： 0161-5505

  225. Internal dosimetry by TLD method and comparison with the result of whole body PET

    HM Deloar, T Fujiwara, M Shidahara, T Nakamura, H Watabe, A Yamadera, M Itoh

    JOURNAL OF NUCLEAR MEDICINE　39　(5)　187P-188P　1998/05

    ISSN： 0161-5505

  226. Radiation Absorbed Dose Estimation of 2-[F-18]Fluoro-2-Deoxy-D-Glucose Using Whole Body PET and Measured Organ Volume MRI

    Deloar H. M., Shidahara M., Fujiwara T., Nakamura T., Miyake M., Watanuki S., Watabe H., Narita M., Itoh M.

    CYRIC annual report　1996　135-140　1996

    Publisher: Cyclotron and Radioisotope Center, Tohoku University

  227. A Registration Method for Medical Images of Different Modalities Using VQ distortion on 2-dimensional Image Intensity Map

    Mizuta Shinobu, Sugimoto Naozo, Watabe Hiroshi, Urayama Shin-ichi, Uyama Chikao

    Proceedings of the Society Conference of IEICE　374　374-374　1996

    Publisher: The Institute of Electronics, Information and Communication Engineers

  228. Imaging of spatial radiation distribution with MCP loaded CCD television camera.

    三宅正泰, DELOAR H, 渡部浩司, 中村尚司

    理工学における同位元素研究発表会要旨集　32nd　1995

  229. Estimation of Organ Biodistribution and Absorbed Dose for Various Radiopharmaceuticals from External Measurement with TLD

    Hayashi Y., Watabe H., Matsumoto M., Miyake M., Nakamura T., Itoh M., Fujiwara T., Takahashi H.

    CYRIC annual report　1993　245-247　1993

    Publisher: Cyclotron and Radioisotope Center, Tohoku University

  230. Assessment of Tumor Blood Flow Using Positron Emission Tomography and H215O: Effect of Hydralazine and Nifedipine

    Abe Y., Yamaguchi T., Matsui H., Takahashi J., Sato T., Fukuda H., Tada M., Hatazawa J., Ito M., Iwata R., Ido T., Watanuki S., Seo S., Watabe H.

    CYRIC annual report　1991　179-182　1991

    Publisher: Cyclotron and Radioisotope Center, Tohoku University

  231. Internal Dosimetry of 11C Labeled Radiopharmaceuticals Used in PET Studies

    Watabe H., Nakamura T., Itoh M., Yanai K.

    CYRIC annual report　1991　283-288　1991

    Publisher: Cyclotron and Radioisotope Center, Tohoku University

  232. Assessment of Tumor Blood Flow Using Positron Emission Tomography and H215O: Effect of Hydralazine

    Abe Y., Yamaguchi T., Matsui H., Takahashi J., Sato T., Yamada K., Fukuda H., Tada M., Hatazawa J., Itoh M., Iwata R., Ido T., Watanuki S., Seo S., Watabe H.

    CYRIC annual report　1990　183-185　1990

    Publisher: Cyclotron and Radioisotope Center, Tohoku University

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Books and Other Publications 12

  1. 放射線取扱の基礎 : 第1種放射線取扱主任者試験の要点

    日本アイソトープ協会

    日本アイソトープ協会,丸善出版 (発売)　2024/03

    ISBN: 9784890732906

  2. Chapter Two - Scattering of e± with Al, Ni, Cu, Ag, Pt, and Au atoms including the relativistic effect at 1 eV ≤ Ei ≤1 MeV

    Elsevier　2023/09

  3. 放射線取扱の基礎 : 第1種放射線取扱主任者試験の要点

    日本アイソトープ協会

    日本アイソトープ協会,丸善出版 (発売)　2021/03

    ISBN: 9784890732838

  4. Basic Science of PET Imaging

    HIROSHI WATABE

    2017

  5. 大学等における申請書等の作成マニュアル 2016年改訂版

    渡部浩司

    2016

  6. 核医学物理学

    渡部浩司, 尾川浩一

    2015

  7. 図解診療放射線技術 実践ガイド

    渡部浩司

    2014

  8. 臨床医とコメディカ ルのための最新クリ ニカル PET

    渡部浩司

    2010

  9. PET お PET/CT よ び 検査技術の基礎

    渡部浩司

    2009

  10. クリニカルPETの最前線

    渡部浩司

    2004

  11. 放射線技術学シリー ズ・核医学検査技術学

    渡部浩司

    2002

  12. 生体情報の可視化技術

    渡部浩司

    1997

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Presentations 29

  1. 全国の放射線作業従事者管理の統一化に向けて Invited

    渡部浩司

    北陸地域アイソトープ研究会　2025/03/04

  2. F-REIにおける放射線科学の進め方 Invited

    渡部浩司

    日本アイソトープ協会東北支部実務セミナー　2025/01/28

  3. 加速器を使ったRI製造 Invited

    放射線創薬セミナー　2025/01/12

  4. RI利用展開のための放射線管理について Invited

    渡部浩司

    第2回短寿命RI利用研究シンポジウム　2024/12/13

  5. F-REIにおける放射線科学に携わる人材の育成 Invited

    渡部浩司

    日本放射化学会　2024/09/25

  6. 核医学における動態解析の過去・現在・未来 Invited

    渡部浩司

    第79回日本放射線技術学会総会学術大会　2023/04/15

  7. 核医学と放射線検出器の現状 Invited

    第32回 放射線・放射能・中性子計測クラブ研究会　2023/03/28

  8. 大学等RI施設の状況と対応 Invited

    渡部浩司

    日本原子力学会2023年春の年会　2023/03/14

  9. 核医学と放射線測定器の現状 Invited

    渡部浩司

    第9回放射線計測専門家会合　2023/02/10

  10. PET marker-less motion correction の検証

    渡部浩司

    核医学画像解析研究会　2022/11/26

  11. 医療用サイクロトロン廃止に関するアドホック委員会活動報告

    渡部浩司

    第4回日本保健物理学会・日本放射線安全管理学会合同大会　2022/11/24

  12. 施設紹介:東北大学サイクロトロン・ラジオアイソトープセンターで植物RIイメージング実験

    渡部浩司

    第59回アイソトープ ・放射線研究発表会　2022/07/08

  13. DATEプロジェクト:医薬理工学連携による新規核医学治療薬の開発 Invited

    渡部浩司

    第42回日本臨床薬理学会学術総会　2021/12/10

  14. DATE プロジェクト - 加速器による診断・治療用アイソトープ製造 Invited

    渡部浩司

    第2回標的アイソトープ治療線量評価研究会　2021/10/09

  15. [18F]FBPAのPET動態解析 Invited

    渡部浩司

    第17回日本中性子捕捉療法学会　2021/07/10

  16. 東北大学サイクロトロン・ラジオアイソトープセンター／電子光理学研究センターにおけるRI製造供給 Invited

    渡部, 浩司, 菊永, 英寿, 池田, 隼人

    第58回アイソトープ・放射線研究発表会　2021/07/08

  17. 大学間ネットワークによる従事者管理の統一化

    第２回日本放射線安全管理学会・日本保健物理学会合同大会　2019/12/06

  18. 複数小型線量計を用いたPET検査内部被ばく評価法の開発

    日本核医学会総会　2019/11/01

  19. Optimization of coincidence time window on Compton imaging of astatine-211 for targeted α-particle radiotherapy

    IEEE MIC 2019　2019/10/26

  20. SINET5を用いた放射線情報一元管理のためのアイソトープ総合センター連携ネットワークの構築

    ADVNET2019　2019/10/04

  21. 短寿命RI利用促進のためのヒアリング調査について

    鈴木智和, 青井考, 渡部浩司, 中野貴志

    アイソトープ・放射線研究発表会　2019/07

  22. 著者の立場から( MRI ・核医学分野) Invited

    渡部浩司

    医学物理学会　2019/04

  23. Automatic evaluation of Pharmacokinetics for Amyloid tracers International-presentation Invited

    Watabe, Hiroshi, nd Nai, Ying HWay, Shidahara, Miho

    17th Annual Conference of The Egyptian Society of Nuclear Medicine Specialists.　2019/03/24

  24. 短寿命核種の管理上の疑問と問題~O‐15ガスを中心に~

    渡部浩司

    日本放射線安全管理学会学術大会講演予稿集　2018/12/05

  25. 頭部PET体動補正精度の装置間比較~統一実験プロトコルを用いた検討~

    猪又嵩斗, 志田原美保, 四月朔日聖一, 小田桐逸人, 南部武幸, 伊藤浩, 田代学, 渡部浩司

    核医学技術　2018/10/04

  26. ハクサンハタザオにおけるカドミウムと亜鉛の輸送過程の追跡

    銭照杰, 黄田毅, 鈴井伸郎, 尹永根, 河地有木, 池田隼人, 池田隼人, 渡部浩司, 北島信行, 簡梅芳, 井上千弘

    環境バイオテクノロジー学会大会プログラム講演要旨集　2018/06/25

  27. 標本PEMを用いた乳房温存手術の最適化のシミュレーション

    渡部剛, 伊藤正敏, 渡部浩司, 宮下穣, 原田成美, 濱中洋平, 佐藤章子, 多田寛, 石田孝宣

    日本乳癌学会学術総会　2018/05/16

  28. FDG‐PETとNIRSの同時測定で発見された抗ヒスタミン薬服用下での脳糖代謝変化と脳血流変化のミスマッチ所見

    菊地飛鳥, 稲見暁惠, 三宅正泰, MOHSEN Attayeb, NASIR Fairuz Mohd, 松田林, 平岡宏太良, 四月朔日聖一, 谷内一彦, 渡部浩司, 田代学

    日本ヒト脳機能マッピング学会　2018/03/02

  29. レボセチリジンの鎮静作用に関する脳ブドウ糖代謝および脳血流の変化の観察

    田代学, 菊地飛鳥, 稲見暁惠, 三宅正泰, MOHSEN Attayeb, MOHSEN Attayeb, NASIR Fairuz, 松田林, 平岡宏太良, 四月朔日聖一, 渡部浩司, 谷内一彦, 谷内一彦

    臨床薬理　2017/11/15

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Research Projects 40

  1. PETの動態解析 Competitive

    1993/04 - Present

  2. Supply Platform of Short-lived Radioisotopes

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Transformative Research Areas (platforms for Advanced Technologies and Research Resources)

    Institution: Osaka University

    2022/04/01 - 2028/03/31

  3. フリームービング小動物PET検査が拓く脳基礎研究の新展開

    志田原 美保, 古本 祥三, 渡部 浩司, 茨木 正信

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2024/04/01 - 2027/03/31

  4. New method for real-time CT imaging during particle cancer therapy

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: National Institutes for Quantum Science and Technology

    2023/04/01 - 2026/03/31

  5. Non-invasive quatitative PET by deep learning of arterial input function

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Akita Prefectural University

    2023/04/01 - 2026/03/31

  6. Quantitative MAO-B imaging of human brain and whole-body organs using [18F]SMBT-1 PET

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2021/04/01 - 2025/03/31

  7. Quantitative brain and whole-body MAO-B imaging with [18F]SMBT-1 and PET

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2021/04/01 - 2025/03/31

  8. Non-invasive monitoring of intra-brain drug concentration using near-infrared spectroscopy (chemical NIRS)

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Research (Exploratory)

    Institution: Tohoku University

    2021/07/09 - 2024/03/31

  9. Development of innovative personalized medicine using real-time miniature dosimeters

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2020/04/01 - 2024/03/31

  10. Study of Off-Target Dose for Proton Boron Fusion Therapy (PBFT) in Pediatric Patients

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for JSPS Fellows

    Institution: Tohoku University

    2021/09/28 - 2023/03/31

  11. 複数個体を対象とする動物PET体動補正で実現する無麻酔・非拘束な生体機能評価

    志田原 美保, 渡部 浩司, 古本 祥三

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 挑戦的研究(萌芽)

    Institution: 東北大学

    2021/07/09 - 2023/03/31

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    病態解明・創薬・難治疾患の治療法開発などの基礎研究を目的として、様々な動物種、遺伝子改変動物、病態モデル動物などを対象としたPET(陽電子断層撮影)検査が麻酔下/拘束条件で実施されている。本研究では、放射性マーカーのトラッキング技術と体動補正技術を融合した複数個体を対象とする動物PET検査により、麻酔・拘束具が不要な真にストレスフリー状態の小動物の統計的な生体機能評価の実現に取り組む。 令和3年度は、放射性マーカーのトラッキング基盤技術開発を行った。マーカートラッキング技術開発のため、プナラーイメージング装置で複数のNa-22の密封線源を連動・計測する基礎実験を行った。この実験で得られた2次元ダイナミック画像に含まれる放射性マーカーを画像処理により検知し時系列にマーカー位置を追跡する基本アルゴリズムの構築を行った。その結果、高検出率でマーカー追跡が可能となった。 次年度は、計画中の放射性マーカーの作成、動物用ケージの作成を行い、ストレスフリーラットの生体機能評価実験に向けた検討を進める予定である。

  12. Novel concept of IVR system based on object identification in X-ray fluroscopic images for drastic dose reduction

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2019/04/01 - 2023/03/31

  13. Elucidation of cesium dynamics in animals and plants using the positron-emitting nuclide Cs-127

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: National Institutes for Quantum Science and Technology

    2019/04/01 - 2023/03/31

  14. Integrated multimodal imaging of brain and muscle activities with PET/MR

    TASHIRO Manabu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Research (Exploratory)

    Institution: Tohoku University

    2017/06/30 - 2021/03/31

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    This project aimed to apply PET/MR to exercise research of skeletal muscles and brain, conducting a muscle activity imaging study on "hand-writing" and "running" tasks, as well as a brain activity imaging study on "running" tasks. We succeeded in confirming the usefulness of simultaneous FDG-PET/MR measurement in exercise physiology and rehabilitation medicine, by obtaining the results of muscular activities of various thin muscles in hands and forearms of healthy of human volunteers. In addition, we were able to partly confirm the usefulness of PET/MR in examining the relationship between glucose uptake (measured with PET) and metabolites changes (measured with MRS) in skeletal muscles of legs and in the brain (prefrontal cortex, motor cortex and hippocampal regions) of healthy volunteers. In conclusion, PET/MR is useful in exercise physiology and rehabilitation medicine.

  15. Development of ultra-high-resolution 3D fluorescent CT using x-ray tube for imaging molecular function and morphology simultaneously

    Zeniya Tsutomu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Hirosaki University

    2017/04/01 - 2021/03/31

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    In this study, the simulation showed that scatter correction is essential for obtaining image quality comparable to that of synchrotron radiation fluorescence CT in fluorescence CT using tube X-rays. In addition, an image reconstruction algorithm applying EM-TV was effective in improving image quality. We developed image analysis software that has a function of superimposing an X-ray fluorescence CT image and a transmitted X-ray CT image. It was shown that a three-dimensional image of a biological sample can be obtained by X-ray fluorescence CT. A fluorescence X-ray CT using tube X-rays could be prototyped, and a three-dimensional image could be obtained. However, in the case of tube X-rays, there are a large number of scattered radiation, and it was found that suppression and correction of scattered radiation are essential for the depiction of trace amounts of labelling substances.

  16. 短寿命RI供給プラットフォーム

    中野 貴志, 福田 光宏, 渡部 浩司, 羽場 宏光, 菊永 英寿, 永津 弘太郎, 酒見 泰寛

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 新学術領域研究（研究領域提案型）『学術研究支援基盤形成』

    Institution: 大阪大学

    2016 - 2021

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    日本アイソトープ協会等から市販品として入手できる研究用RIは長寿命核種に限られているが、この短寿命RI供給支援活動によって研究対象の幅が大きく拡がり、新しい核医学治療・診断薬の開発や植物機能の解明等の基礎研究を進展させる原動力になってきた。潜在的にRI利用研究の可能性を模索していた研究者や、RIの利用が不慣れなために研究に着手できなかった新規ユーザーを開拓することにもつながっており、新規実験課題の件数も堅調である。 平成31年2月と令和元年6月に平成31年度上半期と令和元年度下半期の課題募集を実施し、それぞれの採択課題数は12、17と平成30年度と同程度の件数を示した。平成31年度・令和元年度の採択課題は継続して利用していただいているユーザーによる課題数は24、新規ユーザーによる課題数が5となっている。これまで継続してRIを供給してきたことにより、実験データの品質が増加したことを反映し、継続して使用してきたユーザーによる学術集会での発表数や学術雑誌にて公表した論文数も増加する傾向にある。また、令和元年度にはRI利用技術の講習会を2019年10月に開催し、RI利用の底上げを図った。なお、平成元年度2回目の講習会は2020年3月に開催予定であったが、COVID-19の蔓延を考慮して延期した。 さらに本プラットフォームの活動を周知するために、専用のホームページを充実させていくと共に、学会や各種の学術集会での発表、学術雑誌への寄稿などを通じて本事業の紹介と説明を継続して行ってきた。平成30年度からは、量子科学技術研究開発機構放射線医学総合研究所サイクロトロン施設、さらに令和元年度からは量子科学技術研究開発機構高崎量子応用研究所も本プラットフォームに加わり、大阪大学RCNPの施設および加速器の改修工事期間中であってもこれまで以上に安定なRI供給体制を築くことができた。また、本プラットフォームの円滑な運営のために毎月1回、定例のネットワーク会議を開催し、6施設間の情報共有と懸案事項の審議を行い潤滑な運営を行った。

  17. PET-NIRS fusion imaging for advanced diagnosis of Alzheimer's disease and elucidation of brain function

    WATABE Hiroshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2017/04/01 - 2020/03/31

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    For advanced diagnosis of brain functions, we developed a completely simultaneous measurement method of PET and NIRS. We validated the developed method using [O-15]water PET studies. We also proposed the Clinical Usefulness Index (CUI) value, which can objectively indicate the clinical evaluation of multiple tau protein PET drugs used for the diagnosis of Alzheimer's disease, and evaluated its effectiveness. In addition, we developed a database that can store a large number of modality data for use in multicenter studies.

  18. Development of positron imaging technology for cesium kinetic analysis in plants and animals

    SUZUI Nobuo

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: National Institutes for Quantum and Radiological Science and Technology

    2016/04/01 - 2020/03/31

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    We have developed a positron-emitting cesium tracer and realized non-destructive imaging of cesium dynamics in living animals and plants. First, we have established a method to produce and purify positron-emitting radionuclide, Cs-127 (half-life: 6.25 h). Next, we administered Cs-127 tracer to plants and analyzed the cesium kinetics in various plants using the Plant Research Positron Emission Imaging System (PETIS). Furthermore, we administered Cs-127 tracer to living animals and successfully visualized the cesium dynamics using positron emission tomography (PET).

  19. Measurement of intracerebral drug concentration using magnetic resonance spectroscopy (MRS)

    TASHIRO Manabu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2016/04/01 - 2020/03/31

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    In this project, non-invasive measurement of the intra-cerebral concentrations of orally-administered drugs (e.g. acetoaminophen or diphenhydramine) was tested in healthy humans using MR spectroscopy (MRS) function of PET/MR system. Results suggested it was not yet applicable to the measurement of other drugs although previous studies succeeded in measuring intra-cerebral ethanol concentration in humans. However, the results also demonstrated correlations between the plasma concentration change of the orally-administered drugs and intra-cerebral concentration of some selected brain metabolites. Based on this finding, it might be possible to estimate the intra-cerebral concentrations of orally-administered drugs in future. In addition, additional PET measurement demonstrated an increased cerebral glucose consumption following oral administration of diphenhydramine especially during cognitive tasks. This finding might be useful to evaluate the effects of drugs on human brain activity.

  20. Estimation of Internal radiation dose for PET-MD study using multiple personal dosimeters

    Watabe Hiroshi, TASHIRO Manabu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

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    At present, microdosing study using PET (PET-MD study) is expected to significantly reduce the development period for new drugs. In the PET-MD study, it is first necessary to assess the internal exposure of the subject to the administered radiopharmaceutical and to confirm the safety of the study drug. Conventionally, internal radiation doses have been estimated by animal experiments, but this method ignores species differences and has the problem that individual differences among individual subjects are not taken into account. In this study, we developed a method to directly estimate the internal radiation dose of an individual by multiple small dosimeters on the surface of the subject. In order to verify this method, phantom experiments were conducted to show that the amount of radioactivity and internal exposure in the body could be determined.

  21. Development of a Cherenkov light imaging system for plant study

    Kawachi Naoki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: National Institutes for Quantum and Radiological Science and Technology

    2016/04/01 - 2019/03/31

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    After the accident at the Fukushima Daiichi Nuclear Power Station, large areas of agricultural fields were contaminated with radiocesium. As a result, high-resolution images of radiocesium distribution are required in order to facilitate the study of cesium kinetics in plants. Through Cherenkov light imaging, we can visualize fine distributions of radionuclides that emit beta particles by using an optical camera We have used this method to develop an imaging system that allows us to study radiocesium movement in live plants. To demonstrate the use of this system for radiocesium detection in plants, an imaging experiment was performed with a live soybean plant. The images of Cs-137 distribution in the soybean plant indicate that Cs-137 was transported into the shoot and accumulated at the node. The results of the experiments described above lead us to conclude that Cherenkov light imaging may be a promising method for studying the kinetics of radioisotopes in live plants.

  22. Image fusion using a novel multi-modal imaging marker

    Ose Takayuki, Nakajima Iwao

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Institute of Physical and Chemical Research

    2015/04/01 - 2019/03/31

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    The aim of this study is to develop and evaluate the technology related to the alignment of diagnostic images of different modalities such as PET images and MRI images using multimodal markers. We demonstrated that the material of multi-modal marker which we developed has high contrast in CT and PET/Tx images and has sufficient contrast in both T1w-MRI and T2w-MRI, compared to general MRI contrast agents. We also developed the marker-based registration software and marker containers. This research enabled us to register across different modalities of imaging more easily and accurately than the general software-only method.

  23. Development of a At-211 imaging method with a Compton camera for targeted alpha-particle radiotherapy

    Kawachi Naoki, NAGAO Yuto, YAMAGUCHI Mitsutaka, ISHIOKA Noriko, WATABE Hiroshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: National Institutes for Quantum and Radiological Science and Technology

    2016/04/01 - 2018/03/31

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    Astatine-211 is a promising radionuclide for targeted radiotherapy. It is important to acquire an image of the distribution of targeted radiotherapeutic agents in a patient's body for optimization of treatment strategies. We proposed to image At-211 quantitatively with high-energy photons to overcome some problems in conventional planar gamma camera or single-photon emission computed tomography imaging. We performed an imaging experiment of a point-like At-211 source using a Compton camera, and demonstrated the capability of imaging At-211 with the high-energy photons for the first time.

  24. Cortical architecture and function revealed by multimodal imaging and their association with behaviors

    Hayashi Takuya

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Institute of Physical and Chemical Research

    2015/04/01 - 2018/03/31

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    The purpose of this study is to establish multi-modal information technologies using non-invasive brain imaging. We developed the technique for visualizing distributions of cortical neurite, connectivity, functional properties and collected brain imaging data from human and non-human primates. We achieved scientific publication on cortical neurite properties, which are associated with cortical myelin and microscopic architecture. We continue to establish the functional connectivity imaging and others to address the question how cortical multi-modal information can be useful to explain the behaviours.

  25. Radiation dose imaging based on actual measurement of therapeutic beam for avoidance of medical accidents in radiation cancer therapy

    Kikuchi Yohei

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2015/04/01 - 2018/03/31

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    In conventional radiation, actual exposed dose of patient is not measured and this brings and clinical accident such as over-dose or under-dose in medical front. We propose a real time dose imaging technique to avoid accidents. Use of photovoltaic device to dose measurement was attempted and the signal output performances against radiation expose were revealed. Then, X-ray dose of phantom was successfully obtained using the device. Also, we constructed image reconstruction program which tolerates data truncation and evaluated the performance.

  26. The establishment of breast navigation surgery using Si-PM based intraoperative PET system

    Watanabe Gou

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2015/04/01 - 2018/03/31

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    18F-FDG accumulation of resected specimens in breast-conserving surgery was evaluated with high resolution Positron Emission Mammography (PEM). In 16 cases, the invasive cancer lesion was detectable at 100% (12/12) and the noninvasive cancer lesion was detectable at 94.4% (17/18), and the medical staff exposure was as low as 18 μSV on average. The simulation was carried out when 2 cm margin was removed from the range of PEM accumulation, the amount of resection could be reduced by 58% without additional margin positive cases. Furthermore, we have developed a highly sensitive thin and compact PEM using silicon photomultiplier, which makes it possible to detect 18 F-FDG in the operative field. It was able to separate 1.4 mm spaced pixels.

  27. Study of radiocesium pollution in cherry trees in Fukushima Prefecture.

    SUGIURA HIROYUKI, SAKAI HAJIME, SUEKI KEISUKE, SATO YOSHIHI KO, WATABE HIROSI, MIYAZAKI TAKAMICHI, ONUMA YUTAKA, ABE AKIYOSI

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Fukushima College Junior College

    2015/04/01 - 2018/03/31

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    The adhesions of radiocesium to the surfaces of cherry (Cerasus x yedoensis 'Somei-yoshino') tree bark were studied in northern Fukushima Prefecture. The 137Cs concentration on the bark is related to the radiation dose rate map of November 5, 2011. The 137Cs concentrations at the branch internodes grown in 2010 were three times that in 2011 in the cherry trees. It was believed that only a few radiocesium concentrations would decrease because of rain and transfer to other tree parts from the bark because the percent of exchangeable 137Cs extracted from the bark was 0.35%. The majority of the 137Cs was in the bark; however, there was a small quantity of it in the wood and phloem of the cherry trees. Autoradiography of the radioactive pollution on the surface of the cherry tree bark displayed a random spot pattern. The radioactive spots decreased after decontamination by chipping and were transferred to the latex gloves after treatment of the contaminated bark.

  28. Development of an image reconstruction algorithm for image improvement of ultra-high spatial resolution SPECT for molecular functional quantitation in a selected small region

    ZENIYA Tsutomu, IIDA Hidehiro, WATABE Hiroshi, HAYASHI Takuya, KUDO Hiroyuki, HIRANO Yoshiyuki, KOSHINO Kazuhiro, HORI Yuki, MORIGUCHI Tetsuaki, KAWASHIMA Hidekazu, SATO Tetsuo, HASHIKAWA Yoshiko

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    2014/04/01 - 2018/03/31

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    We are developing an ultra-high spatial-resolution pinhole SPECT system to quantify molecular functions in a selected small region. This study aimed to improve distortion, quantitation and spatial resolution of the image generated in this system. First, it was conformed that the used full-digital detector with multiple position-sensitive photomultiplier tubes had high spatial resolution and no image distortion due to noise suppression. Second, the image quantitation was improved by correcting the effects of attenuation and scatter inside the object in pinhole SPECT image reconstruction. Third, the spatial resolution was improved by correcting the effect of the blurring due to collimator aperture. This study promoted the practical use of this SPECT system

  29. Basic study of image standardization for statistical analysis of nuclear medicine images.

    Watanuki Shoichi, WATABE HIROSHI

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2014/04/01 - 2017/03/31

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    This study aimed to investigate the effectiveness of simulation as the method to define standard data acquisition and processing of nuclear medicine images for reliable statistical analysis. To this aim, we simulate the SET-3000BX (Shimadzu Co.) PET scanner by Geant4 Application for Tomographic Emission (GATE) simulation software and compared the simulated data with an experimental PET data to confirm that the simulated scanner represents the real PET scanner sufficiently. We validated the simulated data by measurements of resolution and sensitivity according to the NEMA NU 2-2007 standard and a hot sphere phantom imaging. The simulated PET scanner could represent the SET-3000BX scanner successfully, and we also obtained the knowledge of the property of image processing in the statistical image analysis were obtained with statistical image analysis of the hot sphere phantom images.

  30. Development of new diagnostic method for dementia by fusion of PET and NIRS

    WATABE HIROSHI, KUBO Hitoshi, WATANUKI Seiichi, SHIDAHARA Miho

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2014/04/01 - 2017/03/31

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    In order to dramatically improve the diagnostic ability of Alzheimer's disease, this study aims to develop a new diagnostic method for PET amyloid β imaging agent and construct a fusion system of PET image and NIRS data. Based on the chemical form of the agent, we could predicted PET data for sevral PET amyloid pharmaceuticals, and derived CUI (clinical usefulness index) to evaluate its diagnostic ability. We also developed a PET/NIRS fusion system using an optical tracking device and evaluated its effectiveness by clinical experiments. As a result, PET and NIRS data were displayed in the same coordinate system in the brain, and analysis of both modalities could be merged.

  31. Species difference in pharmacokinetics of widely used drugs: a PET microdosing study

    Hatazawa Jun

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (S)

    Institution: Osaka University

    2012/05/31 - 2017/03/31

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    In the process of new drug development, species difference in pharmacokinetics induced a failure of clinical trial due to lack of expected treatment effect and/or unexpected adverse effect. The aim of the present study was to establish a method to elucidate species difference in whole-body distribution of new drug candidate compounds by means of animal and human PET studies. We tested two drugs, Donepezil hydrochloride for Alzheimer's disease and borono-phenylalanine for boron neutron capture therapy of intractable cancers. Both compounds showed pharmacokinetic species difference in the PET studies. The present study contributes to rapid and efficient drug development, and to provide safe medicines by reducing unexpected adverse effects not predicted by animal studies.

  32. Quantitative measurement of the tissue B-10 concentration in the boron neutron capture therapy.

    SHIMOSEGAWA Eku, KATO Hiroki, WATABE Hiroshi, ISOHASHI Kayako, KANAI Yasukazu, TATSUMI Mitsuaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Osaka University

    2012/04/01 - 2015/03/31

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    We tested the correlation of F-18 FBPA PET accumulation and B-10 concentrations in normal and the brain tumor model rats and proved that F-18 FBPA PET can estimate the B-10 level of therapeutic dose in boron-neutron capture therapy (BNCT). Also, we evaluated the B-10 concentration of normal organs from dynamic F-18 FBPA PET of the healthy subject and identified organs with the risk about onset of complications after BNCT. Furthermore, we performed F-18 FBPA PET in the cancer bearing patients and demonstrated that tumor / blood ratio was suitable for a standardization index of F-18 FBPA accumulation in the tumor tissue.

  33. Development of an image reconstruction algorithm for sensitivity improvement of ultra-high spatial resolution SPECT for molecular functional quantitation in a selected small region

    ZENIYA Tsutomu, IIDA Hidehiro, WATABE Hiroshi, HAYASHI Takuya, KOSHINO Kazuhiro, HIRANO Yoshiyuki, KUDO Hiroyuki, TERAMOTO Noboru

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: National Cardiovascular Center Research Institute

    2011/04/28 - 2015/03/31

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    We developed an image reconstruction algorithm for ultra-high spatial resolution SPECT system to quantify molecular functions in a selected small region. This algorithm is not affected by lack of data (i.e. truncation). In addition, we improved this algorithm for multi-pinhole SPECT system to improve sensitivity. SPECT study was performed using 8-pinhole collimator with 55-mm field of view. This study showed significant sensitivity improvement which permits short scan.

  34. Preliminary investigation for plant science at Molecular Imaging Center

    WATABE Hiroshi, KAWACHI Naoki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Osaka University

    2011 - 2012

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    We have investigated of carbon nutrient dynamics in a higher plant by using a positron emission tomography, which is one of the most typical imaging apparatus installed at a Molecular Imaging Center in Medicine. Dynamic PET data of 11C activity distribution into root and soil was acquired quantitatively in intact plant body of soybean. This indicates that the three-dimensional photoassimilate translocation into the sink organs of underground was imaged successfully.

  35. Development of an image reconstruction algorithm for ultra high spatial-resolution and quantitative SPECT in a selected small region

    ZENIYA Tsutomu, IIDA Hidehiro, WATABE Hiroshi, HAYASHI Takuya, KOSHINO Kazuhiro, TERAMOTO Noboru, KUDO Hiroyuki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: National Cardiovascular Center Research Institute

    2008 - 2010

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    We developed an image reconstruction algorithm for SPECT system to quantitatively image molecular functions in a selected small region with ultra high spatial resolution. In addition, for imaging with high sensitivity, we applied this algorithm to the system consisting of multiple detectors with multi-pinholes. The computer simulation showed that the combination of this high sensitive system and truncation compensated reconstruction algorithm can provide high-resolution image with high S/N ratio and no effect of truncation in a small region of human brain.

  36. Development of O-17 MRI for brain perfusion analisys

    SATO Hiroshi, IIDA Hidehiro, WATABE Hiroshi, HAYASHI Takuya, ENMI Jyunichiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: National Cardiovascular Center Research Institute

    2007 - 2010

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    Developed rapid Quantification method for T_1_ρ : longitudinal relaxation time in rotating frame in rat brain using phased array coil and EPI with pseudo continuous spin-lock preparation. Measured T_1_ρ perturbation and dispersion by intravenous-injection of water (1ml, 10 atm% of ^<17>O) in rat brain.

  37. Development of the algorithm for quantitative neuroreceptor imaging using PET without serial arterial blood sampling and reference region

    KIMURA Yuichi, ISHIWATA Kiichi, ODA Keiichi, ISHII Kenji, WATABE Hiroshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    2006 - 2007

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    This study aims at developing algorithms for fully quantitative neuroreceptor imaging using PET without serial arterial blood sampling and reference regions. For omission of serial arterial blood sampling, variational Bayesian approach and an intersectional searching approach were investigated based on Logan graphical analysis (LGA). As a result, dynamic studies using FDG, MPDX and TMSX were accomplished without serial arterial blood sampling. The variational Bayesian approach introduces nonnegative constraints to an algorithm based on independent component analysis which has been developed by my group. The approaches improved an estimation performance of a time history of radioactivity in arterial blood (pTAC), and it made an estimated blood volume image, which was another outcome of the algorithm, physiologically reliable. Other algorithm based on LGA is to estimate pTAC using the operational equation of LGA, for which the terms including pTAC were canceled out using pTAC is common among regions. This algorithm was sensitive for noise in PET data due to its mathematical framework. In order to realize reliable pTAC estimation, some data preprocessing procedures were developed using clustering based on a kinetics of administered radiopharmaceutical For the omission of reference region, a feasibility of voxel-based compartment model analysis was investigated. However, it was not practical due to bad noise statistics in voxel-based PET data. Then, total distribution volumes (VT) was estimated for each voxels to decrease the number of estimated rate constants using LGA. The VT estimates by LGA is underestimated under the existence of large noise in PET data. MAP based estimation approach was incorporated with LGA, and fast and statistically reliable voxel-based VT estimation was archived.

  38. 光学式トラッキング装置を用いた腫瘍検査のための画像自動重ね合わせシステムの開発

    渡部 浩司

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 若手研究(B)

    Institution: 国立循環器病センター(研究所)

    2004 - 2006

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    PETとMRI画像との画像重ね合わせのためのシステムの開発を行った。MRI装置は非常に高い磁場環境下にあり、既存の光学式トラッキング装置を使用できない。 そこで、安価なUSBカメラを2台使用した。2台のUSBカメラを固定するための固定治具および、カメラのキャリブレーション用の治具を設計、製作した。これらの治具は非磁性体でできており、強磁場下でも利用できるようにした。また、2つのカメラから得られた画像から三次元的な位置把握のためのソフトウェアを開発した。本ソフトウェアではDirect Linear Transform法を利用し、どのようなカメラ配置でも、三次元的な位置が求められるようにした。 このシステムの評価のために、胸部模擬ファントムを使って検証を行った。胸部模擬ファントムに、MRIに感度の高いGd造影剤を入れ、また、ターゲットとなるマーカーをファントム表面に設置し、そのファントムをMRI装置内に置き、MRI装置による撮像を行い、マーカーの三次元的な位置を、本システムおよび光学式トラッキング装置で観測した。そのファントムを、続いて、PET装置に移動し、PET装置においても、同様に撮像、およびマーカーの観測を行った。この結果、本システムは光学式トラッキング装置に比べ、精度は劣るものの、良好な位置合わせが可能であった。USBカメラを使うことにより、非常に安価に、また、さまざまなモダリティにおいて利用できる医用画像重ね合わせシステムの可能性が示された。

  39. Neuronal netowork during music perception

    IIDA Hidehiro, WATABE Hiroshi, HAYASHI Takuya, SENDA Michio, TANIGUCHI Takashi, OHMORI Mika

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: National Cardiovascular Center Research Institute

    2002 - 2005

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    There have been several studies which were intended to identify cerebral localizations for components of music perceptions, such as rhythm, pitch, and timbre, by means of PET and fMRI. Those studies have been however limited in utilizing rather simple phrases or tonal patterns, and thus such stimuli may not be equivalent to what the subject percept, while listening the artistic music. This study was intended to investigate neural network while listening musical phrases which consisted of more tones with wider dynamic ranges both in volume and pitch compared with previous studies. Subjects consisted of 17 healthy volunteers including 10 professional musicians (piano or keyboard players at least for 10 years) and 7 non-musicians who had no special educations in music. Age ranged from 35 to 45 in both groups, and 8 were male. A 3-Tesla MRI scanner (GE Sigta 3T) was used to acquire sequential T2^* images during continual stimulation of music with a selective attention for rhythm, pitch, timbre, or volume. The scan was followed by T1 and T2 images. Special music stimulation device was equipped, which was consisted of a high-quality 3-Tesla equivalent headphone (Hitachi, Tokyo), yes/no switches, and a music sequencer program (Digital Performer-III). The computer program produces all music stimuli which were previously-composed original-phrases essentially by piano timbre, and also recorded all switch actions to determine performance of the perceptions. All phrases of 2.7 sec were presented in a pair and were consisted of 11 notes, and their volume and tones ranged relatively large so as to provide musical feeling. The MRI session lasted for 8 min and this was repeated three times. Subjects were asked to detect errors in a selective attention involving a yes/no presentation, and were well trained prior to the MRI session using different music phrases. A continuous background cord (G, B-, C, E-,F) was produced during the experiment, aimed at minimizing effects of noise from the MRI scanner. All subject appreciated musicality of the phrases produced in this study, and reported that the noise sounds from the scanner did not disturb the music perception. Correct answering rate was over 70% in both musician and non-musician groups. We found activations preferentially in the left hemisphere, particularly in the superior-temporal lobule for rhythm, pitch and timbre in musicians. Non-musicians also represented preferential activation in left-hemisphere including superior-temporal, pre-frontal and occipital regions, but also in right-hemisphere. The activation in the superior-temporal area is apparently larger in musicians than non-musicians. Rhythm task versus pitch and timbre tasks activated the temporal and pre-frontal areas in musicians, but did not present significant activation in non-musicians in those areas. This study demonstrated that functional anatomy for music perception may be investigated using the present music stimuli system. Activation foci may depend on the education specific to the music training.

  40. Three-dimensional Imaging Display for Clinical Diagnosis and Treatment Supports

    UYAMA Chikao, MIZUTA Shinobu, WATABE Hiroshi, URAYAMA Shin-ichi, SUGIMOTO Naozo

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for General Scientific Research (C)

    Institution: National Cardiovascular Center Research Institute

    1994 - 1995

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    (1) Perfusion area estimation in pulmonary area for pulmonary thromboembolism. While pulmonary SPECT images display blood circulatory area, pulmonary X-ray CT shows pulmonary area. We matched both images demonstrating the volume ratio between them. (2) Three-dimensional display of pulmonary arterial trees for clinical diagnosis of pulmonary thromboembolism. A pair of DSA (digital subtraction angiogram) images were recorded from two directions. A bifurcation point of pulmonary artery in one image corresponded with the point in the other by semi-automatical way. The tree-strcture of pulmonary arteries was displayd so that we can see the tree-structure from any direction. (3) Matching display of ccoronary artery extracted from coronary angiogram and myocardiogram by PET.Three-dimensional coronary arterial structure was constructed from a coronary angiogram taken from two directions. Three-dimensional myocardiac image was recorded by SPECT.By intervention of matching process between left ventriculogram and each of two images, we matched treedimensional images of coronary arteries and myocardiac volume image. (4) Myocardiac contraction analysis using MR tagging images. Myocardiac tagging images were recorded every 50 msec. during 400 msec from the endodiastolic phase. By tracing tagging marker on the time course images, myocardiac movement of 5 mm spacing points were measured. Clinical application of the method is expected. (5) Matching algorithm between images obtained from 2 modalities. PET and MR images of brains were matched by applying a local matching method. Matching among PET images, as well as among MR images were executed and obtained good result. Three-dimensional reconstruction of aortic arch from transverse, coronal and sagital MR images. Since three set of MR images are orthogonal with each other, positioning appropriate planes and projecting the contours of each image to some suitable planes resulted good three-dimensional shape of the aortic arch.

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Works 2

  1. GpetView

    2000/11/24 -

    Type: Software

  2. PyBLD

    2000/10/30 -

    Type: Software

Other 6

  1. PET と光トポグラフィの融合による認知症画像診断の高精度化

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    PETと光トポグラフィの融合を図る研究

  2. 非固定型 PET 検査システムの開発

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    PET検査で頭部を固定せずに検査するシステムを開発する

  3. MIBASE

  4. マイクロ SPECT を利用した機能画像の定量化と循環器疾患の実験的治療研究への応用

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    小動物用マイクロSPECTを利用し、定量解析技術を開発する

  5. 定量的神経画像による線条体疾患の病態解明と治療法開発

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    MRIとPETを用いたサルの脳機能解析ソフトウェアの開発を行う。

  6. PET 胸部検査における体動補正システムの開発と定量的心筋機能評価の迅速・高精度化

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    被検者の動きをモニターするソフトウェアを開発し、心臓の機能評価を行う。

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