Details of the Researcher

PHOTO

Atsushi Hozawa
Section
Graduate School of Medicine
Job title
Professor
Degree

  • 博士（医学）（東北大学）

Research History 5

  • 2023/04 - Present
    東北大学

  • 2012/04 - Present
    Tohoku University　Tohoku Medical Megabank Organization, Department of Preventive Medicine and Epidemiology

  • 2010/04 - 2012/03
    Yamagata University

  • 2008/04 - 2010/03
    Tohoku University

  • 2006/04 - 2008/03
    Shiga University of Medical Science

Education 4

  • Tohoku University

    - 2002

  • Tohoku University　Graduate School, Division of Medical Sciences

    - 2002

  • Tohoku University　Faculty of Medicine

    - 1996

  • Tohoku University　Faculty of Medicine

    - 1996

Research Interests 2

  • Public Health

  • epidemiology

Research Areas 3

  • Life sciences / Hygiene and public health (non-laboratory) /

  • Life sciences / Hygiene and public health (laboratory) /

  • Life sciences / Healthcare management, medical sociology /

Papers 582

  1. Genetic effects on gestational diabetes mellitus and their interactions with environmental factors among Japanese women. International-journal

    Tomoki Kawahara, Nobutoshi Nawa, Keiko Murakami, Toshihiro Tanaka, Hisashi Ohseto, Ippei Takahashi, Akira Narita, Taku Obara, Mami Ishikuro, Masatsugu Orui, Aoi Noda, Genki Shinoda, Yuki Nagata, Satoshi Nagaie, Soichi Ogishima, Junichi Sugawara, Shigeo Kure, Kengo Kinoshita, Atsushi Hozawa, Nobuo Fuse, Gen Tamiya, Wendy L Bennett, Margaret A Taub, Pamela J Surkan, Shinichi Kuriyama, Takeo Fujiwara

    Journal of human genetics　70　(5)　265-273　2025/05

    DOI： 10.1038/s10038-025-01330-4 　

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    Gestational diabetes mellitus (GDM) is common in Japanese women, posing serious risks to mothers and offspring. This study investigated the influence of maternal genotypes on the risk of GDM and examined how these genotypes modify the effects of psychological and dietary factors during pregnancy. We analyzed data from 20,399 women in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort. Utilizing two customized SNP arrays for the Japanese population (Affymetrix Axiom Japonica Array v2 and NEO), we performed a meta-analysis to combine the datasets. Gene-environment interactions were assessed by modeling interaction terms between genome-wide significant single nucleotide polymorphisms (SNPs) and psychological and dietary factors. Our analysis identified two SNP variants, rs7643571 (p = 9.14 × 10-9) and rs140353742 (p = 1.24 × 10-8), located in an intron of the MDFIC2 gene, as being associated with an increased risk of GDM. Additionally, although there were suggestive patterns for interactions between these SNPs and both dietary factors (e.g., carbohydrate and fruit intake) and psychological distress, none of the interaction terms remained significant after Bonferroni correction (p < 0.05/8). While nominal significance was observed in some models (e.g., psychological distress, p = 0.04), the data did not provide robust evidence of effect modification on GDM risk once adjusted for multiple comparisons. These findings reveal novel genetic associations with GDM in Japanese women and highlight the importance of gene-environment interactions in its etiology. Given that previous genome-wide association studies (GWAS) on GDM have primarily focused on Western populations, our study provides new insights by examining an Asian population using a population-specific array.

  2. A Randomized Clinical Trial of ICT-based Interventions for Sodium and Potassium Regulation in Healthy Adults. International-journal

    Yuichiro Yano, Kaori Kitaoka, Takayoshi Ohkubo, Tomonori Okamura, Hiroshi Kanegae, Katsushi Yoshita, Rumi Tsukinoki, Yukiko Okami, Koichi Node, Hiromi Rakugi, Hiroshi Itoh, Katsuyuki Miura

    American journal of hypertension　2025/04/11

    DOI： 10.1093/ajh/hpaf049 　

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    BACKGROUND: There is limited knowledge regarding effective strategies, including information and communication technology (ICT)-based interventions, to reduce sodium intake and increase potassium intake in healthy individuals. METHODS: We conducted a three-month randomized controlled trial involving healthy adult employees with spot urine sodium-to-potassium ratios (spot UNa/UK) ≥4.0 or estimated 24-hour salt intake ≥10g. Estimated 24-hour UNa and UK were calculated using the Tanaka formula. Participants were assigned to one of four groups: (1) online education, where participants monitored their spot UNa/UK and received feedback from dieticians (n=84); (2) messaging, with similar self-monitoring and dietician messages (n=84); (3) self-learning, provided with an educational leaflet (n=87); and (4) a control group (n=87). The primary outcome was the change in spot UNa/UK ratios, and secondary outcomes included changes in estimated 24-hour UNa and UK. The trial protocol specified a hierarchical order for testing the interventions, anticipating the highest efficacy in the online education group. RESULTS: After the intervention, the online education group showed a decrease in spot UNa/UK ratios (mean -0.9 [95% CI -1.8 to 0.0], p=0.052) compared to the control group. The increase in estimated 24-hour UK excretion was larger in the online education compared to control group (mean +2.5 mmol/day [95% CI -0.3 to 5.3], p=0.085). The difference in estimated 24-hour UNa excretion between the online education and control groups was -4.3 mmol/day (95% CI -15.5 to 6.9, p=0.45). CONCLUSIONS: Combining self-monitoring of sodium and potassium intake with ICT-based interventions, including online nutritional education, was associated with a modest reduction in the estimated ratios of sodium and potassium intake in healthy individuals.

  3. Sex difference of genetic risk in the prevalence of atrial fibrillation. International-journal

    Sayuri Tokioka, Masato Takase, Naoki Nakaya, Rieko Hatanaka, Kumi Nakaya, Mana Kogure, Ippei Chiba, Kotaro Nochioka, Hirohito Metoki, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Gen Tamiya, Nobuo Fuse, Shinichi Kuriyama, Satoshi Yasuda, Atsushi Hozawa

    Heart rhythm　2025/03/23

    DOI： 10.1016/j.hrthm.2025.03.1974 　

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    BACKGROUND: Early detection and management of atrial fibrillation (AF) are crucial. Combined models incorporating genetic risks and clinical risks have been developed to improve predictive ability. Although sex differences have been reported in many aspects of AF, sex differences in genetic risk have not been studied. OBJECTIVE: To assess the sex difference in the effect of AF-PRS on AF prevalence using cross-sectional data from the Tohoku Medical Megabank Project Community-Based Cohort Study in Japan. METHODS: Polygenic risk score for AF (AF-PRS) and Cohorts for Heart and Aging Research in Genomic Epidemiology AF (CHARGE-AF) score were used for genetic AF risks and clinical AF risks, respectively. Sex differences in the association of AF-PRS with the prevalence of AF were evaluated. RESULTS: Among 16,853 participants (mean age, 63.4 years and 30.7% men), the prevalence of AF was 4.9% in men and 1.1% in women. In the group with high AF-PRS and high CHARGE-AF score, the odds ratio for AF was highest in men and women (8.2 in men and 9.4 in women), compared to that in the group with low AF-PRS and low CHARGE-AF score. Integrating AF-PRS into the CHARGE-AF score significantly enhanced the area under the curve of receiver operating characteristic for AF in men (from 0.639 to 0.749) but not in women (from 0.710 to 0.733). CONCLUSION: Our study is the first to show a sex difference in the association of AF-PRS and AF prevalence. AF-PRS is more closely associated with the prevalence of AF in men than in women.

  4. Effects of dental prostheses and occlusal force on adverse health outcomes in community-dwelling older adults lacking functional dentition: The Longitudinal Study of the Tsurugaya Project. International-journal

    Daizo Seki, Takamasa Komiyama, Takashi Ohi, Yoshitada Miyoshi, Mana Kogure, Naoki Nakaya, Atsushi Hozawa, Yoshinori Hattori

    The journal of nutrition, health & aging　29　(6)　100534-100534　2025/03/22

    DOI： 10.1016/j.jnha.2025.100534 　

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    OBJECTIVE: In this study, we aimed to examine the longitudinal association between combination of remaining natural teeth (RNT) and functional teeth (FT) or occlusal force (OF), with functional disability and mortality among community-dwelling Japanese adults aged ≥70 years with less than 20 remaining teeth. METHODS: The participants included 916 community-dwelling Japanese adults aged 70 years or older in 2003. Exposures were defined as a combination of RNT and either FT or OF. Outcomes included the incidence of functional disability, determined by the first certification under Japan's long-term care insurance system based on physical and cognitive status, and mortality. The participants were followed up until June 2020. Covariates included age; sex; education; comorbidity; smoking; drinking; physical and cognitive status; and depressive symptoms. Cox proportional hazard models were applied to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for functional disability and death. RESULTS: We observed a higher incidence of death among participants with <20 RNT and fewer FT (<28) than those with functional dentition (HR: 1.62; 95% CI: 1.19-2.21). The HR for death increased as the oral health category based on RNT and FT worsened (p for trend = 0.003). We observed a higher incidence of functional disability (HR: 1.25; 95% CI: 1.02-1.53) and death (HR: 1.30; 95% CI: 1.01-1.68) among those participants with <20 RNT and reduced OF (<200 N) than those with ≥20 RNT. The HR for functional disability (p for trend = 0.029) and death (p for trend = 0.042) increased as the category based on RNT and OF worsened. CONCLUSION: This prospective cohort study demonstrated that a combination of <20 RNT and fewer FT was associated with a higher mortality, whereas a combination of <20 RNT and reduced OF was associated with higher incidence of functional disability and death. Dental prostheses and maintaining OF might play an important role in preserving functionality and promoting survival among older adults with less than 20 remaining teeth.

  5. Association Between Human Milk Oligosaccharides and Early Adiposity Rebound in Children: A Case-Control Study of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Kento Sawane, Ippei Takahashi, Mami Ishikuro, Hiroko Takumi, Masatsugu Orui, Aoi Noda, Genki Shinoda, Hisashi Ohseto, Tomomi Onuma, Fumihiko Ueno, Keiko Murakami, Naoko Higuchi, Tomoko Tanaka, Takashi Furuyashiki, Tomohiro Nakamura, Seizo Koshiba, Kinuko Ohneda, Kazuki Kumada, Soichi Ogishima, Atsushi Hozawa, Junichi Sugawara, Shinichi Kuriyama, Taku Obara

    The Journal of nutrition　2025/03/07

    DOI： 10.1016/j.tjnut.2025.02.024 　

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    BACKGROUND: Adiposity rebound (AR) is the point when the body mass index (BMI) begins to rise again during early childhood. Early AR (before age 5) is associated with a higher risk of lifelong obesity and metabolic disorders and may be influenced by breastfeeding. Although human milk oligosaccharides (HMOs) in breast milk are crucial for child growth, their association with AR status has not been studied. OBJECTIVE: To explore breast milk HMO compositions and molecules associated with AR status in children. METHODS: In this case-control study, we included 184 mother-child pairs from the Tohoku Medical Megabank Project Birth and Three-Generation (TMM BirThree) Cohort Study (93 AR cases, 91 controls). Breast milk was collected 1 month postpartum, and the concentration of 15 HMO molecules and alpha-diversity index (Inverse Simpson index) were quantified. Wilcoxon's rank-sum test and partial least squares-discriminant analysis (PLS-DA) identified candidate HMOs, and multivariable logistic regression analysis evaluated associations between candidate HMOs and AR status. Analyses were stratified by maternal secretor status (secretor or non-secretor). RESULTS: In secretor mothers, multivariable logistic regression showed that the Inverse Simpson index (OR, 0.54 [95% CI, 0.36-0.82]), sum of sialic acid-bound HMOs (0.61 [0.41-0.91]), and 3'-sialyllactose (0.67 [0.46-0.98]) were inversely associated with early AR in a fully adjusted model. A trend of interaction between sialyl-lacto-N-tetraose a (LSTa) and maternal secretor status on AR was observed in a fully adjusted model (P-value for interaction = 0.051). CONCLUSIONS: Alpha diversity, sialic acid-bound HMOs, and 3'SL may be involved in inhibiting AR in children of secretor mothers, and a trend of interactive effect of LSTa among maternal secretor status on AR was indicated. These findings offer novel perspectives on the associations between breastfeeding and a child's adiposity as well as potential metabolic disorders later in life. REGISTRY NUMBER/WEBSITE: https://www.umin.ac.jp/ (trial registration number: UMIN000047160).

  6. Long-term risk of cardiovascular mortality according to age group and blood pressure categories of the latest guideline. International-journal

    Michihiro Satoh, Takayoshi Ohkubo, Katsuyuki Miura, Akiko Harada, Anna Tsutsui, Atsushi Hozawa, Yuji Shimizu, Shizukiyo Ishikawa, Yoshihiro Kokubo, Tomonori Okamura, Yoshitaka Murakami

    Hypertension research : official journal of the Japanese Society of Hypertension　2025/02/20

    DOI： 10.1038/s41440-025-02151-w 　

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    This study examined the association between the latest blood pressure (BP) classification and cardiovascular disease (CVD) mortality risk, using data from 70,570 individuals across 10 Japanese cohorts. Participants were stratified by age (40-64 and 65-89 years) and antihypertensive treatment use. BP was classified according to the 2019 Japanese Society of Hypertension Guidelines. During a follow-up period of approximately 10 years, 2304 CVD deaths occurred. Cox models demonstrated that CVD mortality risk increased stepwise with the BP category, with this association being especially pronounced in patients aged 40-64 years, where the Grade I hypertension group showed the highest population-attributable fraction (PAF). When the treated participants were included in the hypertension group, the overall PAF for CVD mortality was 41.1%. Similar patterns were observed for CVD subtype mortality risk, with hypertension showing particularly high PAFs for intracerebral hemorrhage. These findings highlight the importance of early-stage prevention and management of hypertension.

  7. Association between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium. International-journal

    Rie Kishida, Xin Yin, Sarah Krull Abe, Md Shafiur Rahman, Eiko Saito, Md Rashedul Islam, Qing Lan, Batel Blechter, Nathaniel Rothman, Norie Sawada, Akiko Tamakoshi, Xiao-Ou Shu, Atsushi Hozawa, Seiki Kanemura, Jeongseon Kim, Yumi Sugawara, Sue K Park, Sun-Seog Kweon, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Wei Zheng, Manami Inoue, Daehee Kang, Wei Jie Seow

    International journal of cancer　156　(4)　723-733　2025/02/15

    DOI： 10.1002/ijc.35191 　

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    Family history of lung cancer (FHLC) has been widely studied but most prospective cohort studies have primarily been conducted in non-Asian countries. We assessed the association between FHLC with risk of lung cancer (LC) incidence and mortality in a population of East Asian individuals. A total of 478,354 participants from 11 population-based cohorts in the Asia Cohort Consortium were included. A Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). A total of 7,785 LC incident cases were identified. FHLC (any LC subtype) was associated with an increased risk of LC incidence (HR = 1.45, 95% CI = 1.30-1.63). The positive association was observed in men and women (HR = 1.44, 95% CI = 1.26-1.66 in men; HR = 1.47, 95% CI = 1.22-1.79 in women), and in both never-smokers and ever-smokers (HR = 1.43, 95% CI = 1.18-1.73 in never-smokers; HR = 1.46, 95% CI =1.27-1.67 in ever-smokers). FHLC was associated with an increased risk of lung adenocarcinoma (HR = 1.63, 95% CI: 1.36-1. 94), squamous cell carcinoma (HR = 1.88, 95% CI: 1.46-2.44), and other non-small cell LC (HR = 1.94, 95% CI: 1.02-3.68). However, we found no evidence of significant effect modification by sex, smoking status, and ethnic groups. In conclusion, FHLC was associated with increased risk of LC incidence and mortality, and the associations remained consistent regardless of sex, smoking status and ethnic groups among the East Asian population.

  8. Clinical Effect of Ventricular Entry During Resection of Isocitrate Dehydrogenase-Wildtype Glioblastoma: A Multi-Institutional Analysis. International-journal

    Yoshiteru Shimoda, Ichiyo Shibahara, Masayuki Kanamori, Ken-Ichiro Matsuda, Ryuta Saito, Atsushi Hozawa, Toshihiro Kumabe, Hidenori Endo, Teiji Tominaga, Yukihiko Sonoda

    World neurosurgery　195　123643-123643　2025/01/28

    DOI： 10.1016/j.wneu.2024.123643 　

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    OBJECTIVE: Glioblastomas contacting the subventricular zone (SVZ) are associated with poor prognosis, and the impact of ventricular entry (VE) during resection remains controversial. Since glioblastomas with SVZ involvement often require VE, both SVZ involvement and VE are confounding factors. This study aimed to evaluate the effect of VE during glioblastoma resection by comparing patients with and without SVZ involvement. METHODS: This multi-institutional retrospective study reviewed newly diagnosed isocitrate dehydrogenase-wildtype glioblastoma who underwent resection. The focus was on VE, complications, and recurrence patterns based on SVZ status. RESULTS: A total of 418 patients were included with 278 (66.5%) undergoing VE and 140 (33.5%) without. Patients with VE had significantly shorter overall survival (OS) than those without VE (18.6 vs. 25.6 months, P = 0.008). VE was more common in patients with SVZ tumors (94.2%) compared to non-SVZ tumors (26.3%, P < 0.0001). Notably, 44 patients with non-SVZ tumors experienced VE, whereas 15 patients with SVZ tumors did not. Regardless of SVZ status, VE did not affect the rates of complications, such as symptomatic subdural effusion, hydrocephalus, infection, or nonlocal recurrence. OS was similar for each group: for SVZ tumors, OS was 17.7 months with VE versus 19.9 months without VE (P = 0.34), and for non-SVZ tumors, OS was 30.8 months with VE versus 25.6 months without VE (P = 0.63). CONCLUSIONS: VE during glioblastoma resection does not impact complications or nonlocal recurrence. Surgeons may safely perform VE during resection of both SVZ and non-SVZ glioblastomas without adverse effects.

  9. Reproductive and Hormonal Factors and Thyroid Cancer Risk: Pooled Analysis of Prospective Cohort Studies in the Asia Cohort Consortium. International-journal

    Sayada Zartasha Kazmi, Aesun Shin, Sarah K Abe, Md Rashedul Islam, Md Shafiur Rahman, Eiko Saito, Sooyoung Cho, Ryoko Katagiri, Melissa A Merritt, Ji-Yeob Choi, Xiao-Ou Shu, Norie Sawada, Akiko Tamakoshi, Ritsu Sakata, Atsushi Hozawa, Seiki Kanemura, Jeongseon Kim, Yumi Sugawara, Sue K Park, Hui Cai, Shoichiro Tsugane, Takashi Kimura, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang

    Cancer prevention research (Philadelphia, Pa.)　2025/01/23

    DOI： 10.1158/1940-6207.CAPR-24-0330 　

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    Given the female predominance of thyroid cancer (TC), particularly in the reproductive age range, female sex hormones have been proposed as an aetiology; however, previous epidemiological studies have shown conflicting results. We conducted a pooled analysis using individual data from 9 prospective cohorts in the Asia Cohort Consortium, to explore the association between 10 female reproductive and hormonal factors and TC risk. Using Cox proportional hazards models, cohort-specific hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated and then pooled using a random-effects model. Analyses were stratified by country, birth years, smoking status, body mass index, and TC risk based on age of diagnosis was also examined. Among 259,649 women followed for a mean 17.2 years, 1,353 incident TC cases were identified, 88% (n=1,140) being papillary TC. Older age at first delivery (≥26 vs 21-25 years) was associated with increased TC risk (p-trend=0.003, HR=1.16, 95% CI:1.03-1.31), particularly when diagnosed later in life (≥55 vs <55 years) [p-trend=0.003; HR=1.19, 95% CI:1.02-1.39]. Among younger birth cohorts, women with more number of deliveries showed an increased TC risk [p-trend=0.0001, HR=2.40, 95% CI:1.12-5.18 (≥5 vs 1-2 children)], and there was no substantial trend in older cohorts. Distinct patterns were observed for the number of deliveries and TC risk across countries, with a significant positive association for Korea [p-trend=0.0008, HR=1.89, 95% CI:1.21-2.94 (≥5 vs 1-2 children)], and non-significant inverse associations for China and Japan. Contextual and macrosocial changes in reproductive factors in Asian countries may influence thyroid cancer risk.

  10. Language Registration-Based Scoring System for Handwritten Logical Memory of Wechsler Memory Scale-Revised: Developed and Validated in the Tohoku Medical Megabank Project.

    Naoko Mori, Shunji Mugikura, Atsushi Hozawa, Makiko Taira, Hiroaki Hashizume, Atsushi Sekiguchi, Mitsunari Abe, Michiyo Kasai, Tomo Saito, Kengo Kinoshita, Nobuo Fuse, Shinichi Kuriyama, Masayuki Yamamoto

    The Tohoku journal of experimental medicine　2025/01/16

    DOI： 10.1620/tjem.2025.J006 　

  11. Degree of housing damage caused by the Great East Japan Earthquake and all-cause mortality in the community-based cohort study of the Tohoku Medical Megabank Project. International-journal

    Naoki Nakaya, Kumi Nakaya, Mana Kogure, Yuka Kotozaki, Rieko Hatanaka, Ippei Chiba, Sayuri Tokioka, Masato Takase, Satoshi Nagaie, Hideki Ohmomo, Takahito Nasu, Nobuo Fuse, Kozo Tanno, Atsushi Hozawa

    Journal of epidemiology and community health　2025/01/15

    DOI： 10.1136/jech-2024-223084 　

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    BACKGROUND: Natural disasters may have negative health effects on survivors. However, long-term observations on this are lacking. Therefore, this study investigated the association between the degree of housing damage caused by the Great East Japan Earthquake (GEJE) and all-cause mortality using the data from the cohort study conducted by the Tohoku Medical Megabank (TMM) Project in disaster-stricken areas. METHODS: The community-based cohort study of the TMM Project which conducted a baseline survey from May 2013 to March 2016 collected data using questionnaires and blood and urine tests. The present large-scale prospective cohort study was a follow-up survey in which the degree of house damage and all-cause mortality were analysed using Cox proportional hazards regression, adjusting for sex, age and other potentially confounding variables. The degree of house damage was categorised into 'did not live in the disaster area', 'no damage', 'small-scale damage' and 'large-scale damage'. Among the 58 320 participants, 1763 deaths were confirmed during the follow-up which averaged 6.5 years. RESULTS: The multivariate analysis showed a hazard ratio (95% CI) of 0.96 (0.82 to 1.13) for those who did not live in the disaster area, 0.98 (0.87 to 1.10) for small-scale damage and 0.98 (0.85 to 1.14) for large-scale damage, compared with no damage, but no significant association with all-cause mortality was observed. CONCLUSION: The results of this large-scale prospective cohort study of GEJE survivors showed no significant relationship between the degree of house damage and all-cause mortality. Further long-term follow-up studies are needed to examine the long-term health effects of natural disasters on survivors.

  12. Association Between Sodium- and Potassium-Related Urinary Markers and the Prevalence of Atrial Fibrillation.

    Sayuri Tokioka, Naoki Nakaya, Rieko Hatanaka, Kumi Nakaya, Mana Kogure, Ippei Chiba, Masato Takase, Kotaro Nochioka, Kai Susukita, Hirohito Metoki, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Satoshi Yasuda, Atsushi Hozawa

    Circulation journal : official journal of the Japanese Circulation Society　2025/01/11

    DOI： 10.1253/circj.CJ-24-0780 　

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    BACKGROUND: The primary prevention of atrial fibrillation (AF), which increases mortality through complications including stroke and heart failure, is important. Excessive salt intake and low potassium intake are risk factors for cardiovascular disease; however, their association with AF remains inconclusive. This study investigated the association between sodium- and potassium-related urinary markers and AF prevalence. METHODS AND RESULTS: Data from the Tohoku Medical Megabank Project Community-based Cohort Study were used in this cross-sectional study. The urinary sodium-to-potassium (Na/K) ratio and estimated 24-h sodium and potassium excretion were calculated using spot urine samples and categorized into quartiles (Q1-Q4). The prevalence of AF was the primary outcome. Of the 26,506 participants (mean age 64.8 years; 33.2% males) included in this study, 630 (2.4%) had AF. Using Q1 as the reference group, the odds ratios for AF prevalence in Q4 were 1.35 (95% confidence interval [CI] 1.07-1.73) and 1.59 (95% CI 1.20-2.12) for 24-h estimated urinary Na/K ratio and estimated 24-h sodium excretion, respectively. Estimated 24-h potassium excretion was not associated with AF prevalence. CONCLUSIONS: AF prevalence was positively associated with the urinary Na/K ratio and estimated 24-h urinary sodium excretion, but not with estimated 24-h urinary potassium excretion. Although further prospective studies are warranted, the findings of this study suggest that salt intake may be a modifiable risk factor for AF.

  13. Association between equivalized annual household income and regular medical visits for hypertensive patients since the COVID-19 outbreak. International-journal

    Maya Toyama, Michihiro Satoh, Hideaki Hashimoto, Yutaro Iwabe, Takahito Yagihashi, Shingo Nakayama, Takahisa Murakami, Naoki Nakaya, Hirohito Metoki, Atsushi Hozawa, Takahiro Tabuchi

    Hypertension research : official journal of the Japanese Society of Hypertension　2025/01/08

    DOI： 10.1038/s41440-024-02067-x 　

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    Previous studies have shown an increase in blood pressure during the coronavirus disease 2019 (COVID-19) pandemic even among patients receiving antihypertensive treatment. This study aims to evaluate the association between equivalized annual household income and refraining from regular medical visits for hypertensive patients since the COVID-19 outbreak. We analyzed data from the Japan COVID-19 and Society Internet Survey (JACSIS), including 2832 hypertensive patients aged 20-79 years from the 2020 survey and at least one survey between 2021 and 2023. They were categorized into lower-income (<median of \3,182,000) and higher-income (≥median) groups. Refraining from regular medical visits was defined as not attending scheduled medical visits for hypertension in the past two months. Poisson regression or generalized linear mixed models were used, inverse probability weighted for Internet survey selection. After weighting, the mean age was 64.8 ± 10.3 years and 63.7% were men. In 2020, the proportion of hypertensive patients refraining from regular medical visits after weighting was 19.6% in the lower-income group and 8.8% in the higher-income group, with an adjusted proportion ratio (95% confidence interval) of 1.86 (1.13-3.06) for the lower-income group compared with the higher-income group. After 2020, the proportion of those refraining from regular medical visits declined in all income groups, and the income-related differences disappeared. During the social restrictions due to the COVID-19 pandemic, hypertensive patients with lower equivalized annual household incomes were more likely to refrain from regular medical visits. Strategies to reduce income-related inequities in medical care utilization may be necessary for future public health crises. A nationwide Internet survey in Japan revealed hypertensive patients with lower equivalized annual household incomes were significantly more likely to refrain from regular medical visits in 2020, during the social restrictions due to the COVID-19 pandemic. Addressing income-related inequities in medical care utilization is crucial for future public health crises.

  14. Prevalence and Associations of Epiretinal Membrane by OCT in a Japanese Population-Based Cohort: Tohoku Medical Megabank Organization Eye Study. International-journal

    Akihiko Shiraki, Atsushi Hirayama, Nobuo Fuse, Ryo Kawasaki, Satoko Fujimoto, Tomoyuki Okazaki, Susumu Sakimoto, Takatoshi Maeno, Makiko Taira, Tomo Saito, Tomohiro Nakamura, Soichi Ogishima, Atsushi Hozawa, Kengo Kinoshita, Masayuki Yamamoto, Kohji Nishida

    Ophthalmology science　5　(4)　100752-100752　2025

    DOI： 10.1016/j.xops.2025.100752 　

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    PURPOSE: To examine the prevalence of epiretinal membrane (ERM) according to the OCT-based severity scales, and to describe associations focusing on the impact of smoking and axial length of the globe. DESIGN: Cross-sectional study. PARTICIPANTS: The baseline examination cohort comprised participants from the Tohoku Medical Megabank community cohort recruited from 2013 to 2017. METHODS: In total, 38 118 eyes of 19 486 participants were classified with ERM staging. The characteristics of ERM severity were analyzed, and the association between the prevalence of ERM and ocular and systemic parameters was investigated using logistic regression models. Cubic spline models were constructed to visualize the relationships with lifetime smoking exposure and axial lengths. Regarding ERM severity, the associations between stage 1 and stage 2 or more were analyzed with multivariate analysis. MAIN OUTCOME MEASURES: Epiretinal membrane prevalence at each stage determined via OCT and factors associated with ERM presence and severity. RESULTS: The prevalence of ERM was 2.3% per eye (3.6% per person), with a predominance at stage 1. The presence of severe ERM stages was higher in older individuals. The multivariate logistic analysis revealed that older age, female sex, and long axial length were associated with a higher prevalence of ERM. In a multivariate analysis stratified by sex, glaucoma was also identified as a significant factor associated with the prevalence of ERM in women. In the cubic spline model, no consistent trend was observed between smoking and ERM prevalence. However, a U-shaped relationship was indicated between axial length and ERM prevalence. Epiretinal membrane severity highlighted older age, alcohol consumption, and very long axial length as significantly associated compared with stage 1. CONCLUSIONS: Epiretinal membrane prevalence was significantly associated with older age, female sex, and long axial length. FINANCIAL DISCLOSURES: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

  15. Has the impact of cigarette smoking on mortality been underestimated by overlooking second-hand smoke? Tohoku medical megabank community-based cohort study. International-journal

    Masato Takase, Naoki Nakaya, Kozo Tanno, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Kotaro Nochioka, Takahiro Tabuchi, Taku Obara, Mami Ishikuro, Yuka Kotozaki, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Takahito Nasu, Hideki Ohmomo, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Yoko Izumi, Atsushi Hozawa

    BMJ public health　3　(1)　e001746　2025/01

    DOI： 10.1136/bmjph-2024-001746 　

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    OBJECTIVES: Previous studies have assessed the impact of active smoking on mortality using the population-attributable fraction (PAF). However, these studies have not included second-hand smoking (SHS), potentially underestimating smoking's impact. We compared the PAF from active smoking alone with the PAF, including SHS exposure. DESIGN: Prospective cohort study. SETTING: A community-based cohort study in Japan. PARTICIPANTS: 40 796 participants aged ≥20 years. MAIN OUTCOME MEASURES: SHS was defined as inhaling someone else's cigarette smoke at the workplace or home in the past year. We classified smoking status and SHS into ten categories: never-smoker without SHS, never-smoker with SHS, past smoker without SHS, past smoker with SHS, current smoker 1-9 cigarettes/day without SHS, current smoker 1-9 cigarettes/day with SHS, 10-19 cigarettes/day without SHS, 10-19 cigarettes/day with SHS, ≥20 cigarettes/day without SHS and ≥20 cigarettes/day with SHS. The main outcome was all-cause mortality. RESULTS: During the median follow-up period of 6.5 (5.7-7.5) years, 788 men and 328 women died. For men, compared with never-smokers without SHS, past smokers without SHS (HR, 1.39 [95% CI, 1.11 to 1.73]) and past smokers with SHS (HR, 1.48 (95% CI, 1.10 to 2.00)) were associated with all-cause mortality. For women, never-smokers with SHS had a significantly higher risk of all-cause mortality (HR, 1.36 (95% CI, 1.00 to 1.84)). Without considering SHS, 28.0% and 2.3% of all-cause mortality in men and women, respectively, were attributable to past and current smoking. Including SHS, PAF increased to 31.3% in men and 8.4% in women. CONCLUSIONS: We clarified that smoking's impact was underestimated by not accounting for SHS, especially in women. Information on SHS is crucial for understanding smoking's health impact. This study supports the importance of avoiding smoking and preventing SHS.

  16. Association of Parity with Type 2 Diabetes Mellitus in Japan. International-journal

    Hongxin Wang, Noriyuki Iwama, Keiichi Yuwaki, You Nakamichi, Hirotaka Hamada, Hasumi Tomita, Kazuma Tagami, Rie Kudo, Natsumi Kumagai, Hirohito Metoki, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Yaegashi, Masatoshi Saito

    Reproductive sciences (Thousand Oaks, Calif.)　2024/12/11

    DOI： 10.1007/s43032-024-01752-z 　

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    This study investigates the association between parity and type 2 diabetes mellitus (T2DM) in Japanese women, considering the clinical history of gestational diabetes mellitus (GDM) and menopausal status, which are known risk factors for T2DM. Overall, 30,116 Japanese women (6,588 premenopausal and 23,528 postmenopausal) were included in this cross-sectional study. They were divided into two groups according to menopausal status (premenopausal and postmenopausal women), and the association between parity and T2DM was evaluated using a multiple logistic regression model with possible confounders, including a clinical history of GDM. The association between parity and T2DM was not statistically significant in premenopausal women. In contrast, a linear graded association between parity and T2DM was found in postmenopausal women. Furthermore, the association between parity and T2DM in postmenopausal women was attenuated after adjusting for body weight gain after the age of 20 years. A clinical history of GDM was significantly associated with a high risk for T2DM, regardless of adjustment for body weight gain after the age of 20 years in both premenopausal and postmenopausal women. Parity is associated with an increased risk of T2DM in postmenopausal women but not in premenopausal women. Maintaining appropriate body weight would be beneficial in attenuating the risk of T2DM in postmenopausal women. A clinical history of GDM is a risk factor for T2DM in both pre- and postmenopausal women; therefore, women with a clinical history of GDM require continuous medical care to survey for T2DM.

  17. Age at menarche by birth cohort: A pooled analysis of half a million women in Asia. International-journal

    Sarah K Abe, Marisa Nishio, Hsi-Lan Huang, Chi Yan Leung, Md Rashedul Islam, Md Shafiur Rahman, Eiko Saito, Aesun Shin, Melissa A Merritt, Ji-Yeob Choi, Ryoko Katagiri, Zahra Mohammadi, Xiao-Ou Shu, Kenji Wakai, Norie Sawada, Yuki Ideno, Akiko Tamakoshi, Wei Jie Seow, Woon-Puay Koh, Ritsu Sakata, Atsushi Hozawa, Jeongseon Kim, Chisato Nagata, Yumi Sugawara, Sue K Park, Sun-Seog Kweon, Fereidoun Azizi, Reza Malekzadeh, Foong-Ming Moy, Farhad Pourfarzi, Yu-Tang Gao, Yoko Kubo, Mayo Hirabayashi, Kazue Nagai, Takashi Kimura, Jian-Min Yuan, Seiki Kanemura, Keiko Wada, Daehee Kang, Min-Ho Shin, Davood Khalili, Hossein Poustchi, Abbas Rezaianzadeh, Fariborz Mansour-Ghanaei, Farid Najafi, Iraj Mohebbi, Paolo Boffetta, Jung Eun Lee, Keitaro Matsuo, Nathaniel Rothman, You-Lin Qiao, Wei Zheng, Manami Inoue

    Public health　237　130-134　2024/12

    DOI： 10.1016/j.puhe.2024.09.020 　

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    OBJECTIVES: To evaluate changes in the age at menarche in Asian populations. STUDY DESIGN: Retrospective cohort study. METHODS: We included 548,830 women from six countries in Asia. The data were sourced from 20 cohorts participating in the Asia Cohort Consortium (ACC) and two additional cohort studies: Japan Multi-institutional Collaborative Cohorts (J-MICC), and Japan Nurse Health Study (JNHS) with data on age at menarche. Joinpoint regression was used to evaluate changes in age at menarche by birth year and by country. RESULTS: The study includes data from cohorts in six Asian countries namely, China, Iran, Japan, Korea, Malaysia and Singapore. Birth cohorts ranged from 1873 to 1995. The mean age of menarche was 14.0 years with a standard deviation (SD) of 1.4 years, ranged from 12.6 to 15.5 years. Over 100 years age at menarche showed an overall decrease in all six countries. China showed a mixed pattern of decrease, increase, and subsequent decrease from 1926 to 1960. Iran and Malaysia experienced a sharp decline between about 1985 and 1990, with APC values of -4.48 and -1.24, respectively, while Japan, South Korea, and Singapore exhibited a nearly linear decline since the 1980s, notably with an APC of -3.41 in Singapore from 1993 to 1995. CONCLUSIONS: Overall, we observed a declining age at menarche, while the pace of the change differed by country. Additional long-term observation is needed to examine the contributing factors of differences in trend across Asian countries. The study could serve as a tool to strengthen global health campaigns.

  18. Evaluation of depression at 6 and 12 months postpartum by examining depressive symptoms and self-harm ideation during the early postpartum period: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Masatsugu Orui, Taku Obara, Mami Ishikuro, Aoi Noda, Genki Shinoda, Keiko Murakami, Noriyuki Iwama, Ippei Chiba, Kumi Nakaya, Rieko Hatanaka, Mana Kogure, Natsuko Kobayashi, Saya Kikuchi, Hirohito Metoki, Masahiro Kikuya, Naoki Nakaya, Atsushi Hozawa, Hiroaki Tomita, Shinichi Kuriyama

    PCN reports : psychiatry and clinical neurosciences　3　(4)　e70025　2024/12

    DOI： 10.1002/pcn5.70025 　

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    AIM: The aim of this study was to evaluate depression at 6 and 12 months postpartum, using the Edinburgh Postpartum Depression Scale (EPDS) total score and its subitem regarding self-harm ideation (SHI) at 1 month postpartum. METHODS: A sample of 12,358 postpartum women answered the EPDS and questionaries at 1, 6, and 12 months postpartum longitudinally. RESULTS: For participants with postpartum depression (PPD; EPDS total score ≥9) and SHI (SHI sub-score ≥1) at 1 month postpartum, the risk of depression at 6 and 12 months postpartum (odds ratio [95% confidence interval] at 6 and 12 months postpartum: 20.03 [16.8-23.8] and 14.55 [12.3-17.2], respectively) was higher than for those with PPD but without SHI at 1 month postpartum (OR: 8.57 [7.36-10.0], and 6.24 [5.38-7.24], respectively). Additionally, SHI even without depressive symptoms at 1 month postpartum is also a risk for depression at 6 and 12 months postpartum. To support our longitudinal evaluation of depression at 6 and 12 months postpartum, these related factors were examined: traumatic events or relocations after the Great East Japan Earthquake, employment status, household income, personality traits, sleep status, psychological distress, and social networks. The result showed employment status, low household income and poor social networks were significantly associated with depression at 12 months postpartum but not at 6 months postpartum. CONCLUSION: This study showed a high risk of depression at 6 and 12 months postpartum for those who had depressive symptoms with SHI at 1 month postpartum. Our findings may contribute to the precise evaluation of depression at 6 and 12 months postpartum while considering sleep status, psychological distress and social network during pregnancy.

  19. Body mass index and breast cancer risk in premenopausal and postmenopausal East Asian women: a pooled analysis of 13 cohort studies. International-journal

    Keiko Wada, Koshi Kuboyama, Sarah Krull Abe, Md Shafiur Rahman, Md Rashedul Islam, Eiko Saito, Chisato Nagata, Norie Sawada, Akiko Tamakoshi, Xiao-Ou Shu, Ritsu Sakata, Atsushi Hozawa, Seiki Kanemura, Hidemi Ito, Yumi Sugawara, Sue K Park, Sun-Seog Kweon, Ayami Ono, Takashi Kimura, Wanqing Wen, Isao Oze, Min-Ho Shin, Aesun Shin, Jeongseon Kim, Jung Eun Lee, Keitaro Matsuo, Nathaniel Rothman, You-Lin Qiao, Wei Zheng, Paolo Boffetta, Manami Inoue

    Breast cancer research : BCR　26　(1)　158-158　2024/11/14

    DOI： 10.1186/s13058-024-01907-5 　

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    BACKGROUND: It has been suggested that the association between body mass index and breast cancer risk differs between Asian women and Western women. We aimed to assess the associations between body mass index and breast cancer incidence in East Asian women. METHODS: Pooled analyses were performed using individual participant data of 319,189 women from 13 cohort studies in Japan, Korea, and China. Participants' height and weight were obtained by measurement or self-reports at cohort baseline. Breast cancer was defined as code C50.0-C50.9 according to the International Classification. Using a Cox proportional hazards model, hazard ratios of breast cancer were estimated for each body mass index category, with the reference group set as the group with a body mass index of 21 to < 23 kg/m2. The hazard ratio for a 5 kg/m2 increase in body mass index was also calculated. RESULTS: During a mean 16.6 years of follow-up, 4819 women developed breast cancer. Similar to Westerners, a steady increase in breast cancer risk with increasing body mass index was observed in postmenopausal women, but the slope of the risk increase appeared to slow at a body mass index of 26-28 kg/m2. In premenopausal women, the inverse association seen in Westerners was not observed. The risk of developing breast cancer after 50 years of age increased slightly with increasing body mass index, which was more pronounced in the older birth cohort. There was no significant association between body mass index and the risk of developing breast cancer before 50 years of age, but the risk estimates changed from positive to negative as the birth cohort got younger. CONCLUSIONS: In East Asia, the role of body mass index in breast cancer in premenopausal women may be changing along with the increase in obesity and breast cancer. The increased risk of postmenopausal breast cancer with a higher body mass index was as robust as that of Western women.

  20. Effect of Social Support on Caregiver's Functional Disability Due to Spouse's Functional Disability. International-journal

    Toshimasa Sone, Naoki Nakaya, Yumi Sugawara, Kumi Nakaya, Masayuki Hoshi, Takahiro Tabuchi, Atsushi Hozawa

    Journal of the American Medical Directors Association　105324-105324　2024/10/23

    DOI： 10.1016/j.jamda.2024.105324 　

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    OBJECTIVES: To examine the effect of social support on the risk of caregiver's functional disability due to spouse's functional disability. DESIGN: Longitudinal study. SETTING AND PARTICIPANTS: In this cohort study using the Ohsaki Cohort 2006 Study data, the baseline survey was conducted from December 1, 2006, to December 15, 2006, and included 7598 older adults, including 3799 couples, ≥65 years of age. METHODS: The incidence of spouse's functional disability was defined as certification for the Long-term Care Insurance, which uses a nationally uniform standard of functional disability. The primary outcome was the incidence of the caregiver's functional disability, and the follow-up period was between December 16, 2006, and November 30, 2019. Five social support questionnaires were used to assess the degree of emotional and instrumental social support available to each participant. The Cox proportional hazards model was used to evaluate the incidence of functional disability among caregivers after the occurrence of spouses' functional disability. Subgroup analyses were also conducted according to the status of emotional and instrumental social support. RESULTS: The caregiver's functional disability increased significantly among those whose spouses had functional disability compared with those whose spouses had no disability (multivariate hazard ratio [HR], 1.86). Emotional and instrumental social support showed significant positive interactions on this association (emotional and instrumental support: P for interaction < .01 and < .01, respectively), and the risk of caregiver's disability was higher among those without social support than among those with social support (with emotional support: HR, 1.84; without emotional support: HR, 2.51; with instrumental support: HR, 1.85; without instrumental support: HR, 2.31). CONCLUSIONS AND IMPLICATIONS: Social support may help to alleviate the increased risk for caregiver's functional disability due to the spouse's functional disability.

  21. Associations between leisure time, non-leisure time physical activity, and kidney function in Japanese adults: a cross-sectional study. International-journal

    Ippei Chiba, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Sayuri Tokioka, Tomohiro Nakamura, Satoshi Nagaie, Soichi Ogishima, Taku Obara, Toshimi Sato, Nobuo Fuse, Yoko Izumi, Shinichi Kuriyama, Atsushi Hozawa

    BMC nephrology　25　(1)　354-354　2024/10/16

    DOI： 10.1186/s12882-024-03813-6 　

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    BACKGROUND: Chronic kidney disease (CKD) contributes to decreased life expectancy. We examined the association between leisure-time physical activity (LTPA), non-leisure-time physical activity (non-LTPA) and kidney function. METHODS: This was a cross-sectional study including 32 162 community-dwelling adults aged ≥ 20 years from the Tohoku Medical MegaBank community-based cohort study. Kidney function was evaluated using cystatin C-based estimated glomerular filtration rate (eGFR) as well as self-reported LTPA and non-LTPA. CKD was defined as either eGFR decline (≤ 60 mL/min/1.73 m2) or presence of albuminuria (albumin-creatinine ≥ 30 mg/g). The association between domain-specific physical activity and kidney function, and CKD prevalence was examined using multivariable-adjusted ordinary least squares and modified Poisson models. RESULTS: The mean eGFR was 98.1 (± 13.2) mL/min/1.73 m2. 3 185 (9.9%) participants were classified as having CKD. The mean LTPA and non-LTPA levels were 2.9 (± 4.2) and 16.6 (± 14.2) METs-hour/day, respectively. For LTPA, in the adjusted model, the quartile groups with higher levels had a higher kidney function (β, 0.36; 95% confidence intervals [CI], [0.06, 0.66]; p = 0.019 for the 2nd quartile, β, 0.82; 95% CI, [0.51, 1.14]; p < 0.001 for the 3rd quartile, and β, 1.16; 95% CI, [0.83, 1.49]; p < 0.001 for the 4th quartile), whereas there were no apparent associations for prevalence of CKD. For non-LTPA, 4th quartile was associated with decreased eGFR (β, -0.42; 95% CI, [-0.72, -0.11]; p = 0.007) and higher prevalence of CKD prevalence (Prevalence ratio, 1.12; 95% CI, [1.02, 1.24]; p = 0.022). These associations with kidney function remained consistent in the subgroup analyses divided by demographic and biological variables. CONCLUSIONS: We observed a positive association between higher LTPA levels and better kidney function, but not association with CKD prevalence. In contrast, higher non-LTPA was negatively associated with both kidney function and CKD prevalence. These findings suggest that promoting LTPA is beneficial for kidney function.

  22. Practical use and target value of urine sodium-to-potassium ratio in assessment of hypertension risk for Japanese: Consensus Statement by the Japanese Society of Hypertension Working Group on Urine Sodium-to-Potassium Ratio. International-journal

    Takashi Hisamatsu, Mana Kogure, Yasuharu Tabara, Atsushi Hozawa, Atsushi Sakima, Takuya Tsuchihashi, Katsushi Yoshita, Hitomi Hayabuchi, Koichi Node, Yukari Takemi, Takayoshi Ohkubo, Katsuyuki Miura

    Hypertension research : official journal of the Japanese Society of Hypertension　2024/10/08

    DOI： 10.1038/s41440-024-01861-x 　

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    Epidemiological studies have demonstrated that the urine sodium-to-potassium (Na/K) ratio is more positively associated with high blood pressure and cardiovascular disease risk than either urine sodium or potassium excretion alone. In this consensus statement, we recommend using the average Na/K ratio of casual urines randomly taken in various times on at least four days a week for a reliable individual estimate because of high day-to-day and intraday variability of casual urine Na/K ratio within individuals. Although a continuous positive association exists between the Na/K ratio and high blood pressure or cardiovascular disease risk, for clinical and public health decision making for Japanese, we recommend using an average urine Na/K ratio of 2 as an optimal target value because this aligns with recommendations for both sodium and potassium intake in the Dietary Reference Intakes for Japanese, 2020, considering a typical Japanese dietary pattern. We also suggest that an average urine Na/K ratio of 4 is a feasible target value to achieve a temporary goal of being below the mean values of the urine Na/K ratio across Japanese general populations. These recommendations apply mainly for apparently healthy individuals, but not for patients with specific conditions due to the lack of supporting data. Current evidence for the usefulness of measuring the urine Na/K ratio for the prevention or control of hypertension remains inconclusive and warrants further investigation.

  23. 喫煙歴と受動喫煙の組み合わせと総死亡の関連

    高瀬 雅仁, 中谷 直樹, 丹野 高三, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 時岡 紗由理, 永家 聖, 事崎 由佳, 大桃 秀樹, 田淵 貴大, 寳澤 篤

    日本公衆衛生学会総会抄録集　83回　265-265　2024/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  24. 独居と総死亡の関連 東北メディカル・メガバンク地域住民コホート調査

    事崎 由佳, 中谷 久美, 中谷 直樹, 小暮 真奈, 千葉 一平, 畑中 里衣子, 高瀬 雅仁, 時岡 紗由理, 永家 聖, 大桃 秀樹, 寶澤 篤, 丹野 高三

    日本公衆衛生学会総会抄録集　83回　362-362　2024/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  25. Proposal of reference value for day-to-day blood pressure variability based on two outcomes: the Ohasama study. International-journal

    Michihiro Satoh, Hirohito Metoki, Masahiro Kikuya, Takahisa Murakami, Yukako Tatsumi, Megumi Tsubota-Utsugi, Takuo Hirose, Azusa Hara, Kyoko Nomura, Kei Asayama, Atsushi Hozawa, Yutaka Imai, Takayoshi Ohkubo

    Journal of hypertension　42　(10)　1769-1776　2024/10/01

    DOI： 10.1097/HJH.0000000000003800 　

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    BACKGROUND: This study aimed to propose reference values for day-to-day home blood pressure (BP) variability that align with the established hypertension threshold of home BP for the risk of two different outcomes: cardiovascular mortality and cognitive decline. METHODS: This prospective study was conducted in Ohasama town, Japan, with 1212 participants assessed for cardiovascular mortality risk (age: 64.7 years, 33.6% men). Additionally, 678 participants (age: 62.7 years, 31.1% men) were assessed for cognitive decline risk (Mini-Mental Scale Examination score <24). The within-individual coefficient of variation (CV) of home morning SBP (HSBP) was used as the index of day-to-day BP variability (%). Adjusted Cox regression models were used to estimate the HSBP-CV values, which provided the 10-year outcome risk at an HSBP of 135 mmHg. RESULTS: A total of 114 cardiovascular deaths and 85 events of cognitive decline (mean follow-up:13.9 and 9.6 years, respectively) were identified. HSBP and HSBP-CV were associated with increased risks for both outcomes, with adjusted hazard ratios per 1-standard deviation increase of at least 1.25 for cardiovascular mortality and at least 1.30 for cognitive decline, respectively. The adjusted 10-year risks for cardiovascular mortality and cognitive decline were 1.67 and 8.83%, respectively, for an HSBP of 135 mmHg. These risk values were observed when the HSBP-CV was 8.44% and 8.53%, respectively. CONCLUSION: The HSBP-CV values indicating the 10-year risk of cardiovascular mortality or cognitive decline at an HSBP of 135 mmHg were consistent, at approximately 8.5%. This reference value will be useful for risk stratification in clinical practice.

  26. Genetic Risk, Lifestyle Adherence, and Risk of Developing Hyperuricaemia in a Japanese Population

    Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Akira Narita, Taku Obara, Mami Ishikuro, Hisashi Ohseto, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Biobank Japan Project; Koichi Matsuda, Yoko Izumi, Kengo Kinoshita, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

    Rheumatology　2024/09/13

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/rheumatology/keae492 　

    ISSN： 1462-0324

    eISSN： 1462-0332

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    Abstract Objective To investigate the inter-relationships among genetic risk, healthy lifestyle adherence, and hyperuricaemia susceptibility. Methods This prospective cohort study was conducted with 7,241 hyperuricaemia-free individuals aged ≥ 20 years from the Tohoku Medical Megabank Community-based cohort study. A comprehensive lifestyle score included body mass index, smoking, drinking, and physical activity, and a polygenic risk score (PRS) was constructed based on uric acid loci from a previous genome-wide association study meta-analysis. A multiple logistic regression model was used to estimate the association between genetic risk, healthy lifestyle, and hyperuricaemia incidence and calculate the area under the receiver operating characteristic curve (AUROC). Hyperuricaemia was defined as a uric acid level ≥7.0 mg/dl or a self-reported history of hyperuricaemia. Results Of the 7,241 adults (80.7% females; mean [SD] age: 57.7 [12.6] years), 217 (3.0%) developed hyperuricaemia during 3.5 years of follow-up. Genetic risk correlated with hyperuricaemia development (P for interaction = 0.287), and lifestyle risks were independently associated. Those with a high genetic risk and poor lifestyle had the highest risk (odds ratio: 5.34; 95% confidence interval [CI]: 2.61–12.10). Although not statistically significant, incorporating the PRS in the model with lifestyle information improved predictive ability (AUROC = 0.771, 95% CI: 0.736–0.806 for lifestyle; AUROC = 0.785, 95% CI: 0.751–0.819 for lifestyle and PRS; p = 0.07). Conclusion : A healthy lifestyle to prevent hyperuricaemia, irrespective of genetic risk, may mitigate the genetic risk. Genetic risk may complement lifestyle factors in identifying individuals at a heightened hyperuricaemia risk.

  27. Prospective associations of screen time at age 2 with specific behavioral subscales at age 3: a cohort study. International-journal

    Ippei Takahashi, Taku Obara, Mami Ishikuro, Masatsugu Orui, Aoi Noda, Genki Shinoda, Fuji Nagami, Atsushi Hozawa, Tomoko Nishimura, Kenji J Tsuchiya, Shinichi Kuriyama

    Journal of public health (Oxford, England)　2024/09/11

    DOI： 10.1093/pubmed/fdae240 　

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    BACKGROUND: We aim to discover which, if any, of the subscales of internalizing and externalizing behavioral problems at age 3 are still associated with screen time (ST) at age 2 after adjusting for behavioral problems scores at age 2. METHODS: This study was conducted under the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Information was gathered prospectively, with 7207 mother-child pairs included in the analysis. Children's ST was categorized in hours a day at age 2 (<1, 1-<2, 2-<4, ≥4). We assessed children's behavioral problems using the Child Behavior Checklist for Ages 1½-5 (CBCL) at ages 2 and 3. 'Having behavioral problems' was defined by them being within a clinical range for internalizing behaviors (withdrawn, somatic complaints, anxious/depressed and emotionally reactive) and externalizing behaviors (attention problems and aggressive behaviors) at age 3. Continuous scores on each of the behavioral problem scales at age 2 were used as covariates. RESULTS: Greater ST for children at age 2 was associated with specific subscales for emotionally reactive and aggressive behaviors at age 3. CONCLUSIONS: This study found that ST is prospectively associated with some behavioral scales but not others.

  28. Genome-wide association study based on clustering by obesity-related variables uncovers a genetic architecture of obesity in the Japanese and the UK populations. International-journal

    Ippei Takahashi, Hisashi Ohseto, Fumihiko Ueno, Tomomi Oonuma, Akira Narita, Taku Obara, Mami Ishikuro, Keiko Murakami, Aoi Noda, Atsushi Hozawa, Junichi Sugawara, Gen Tamiya, Shinichi Kuriyama

    Heliyon　10　(16)　e36023　2024/08/30

    DOI： 10.1016/j.heliyon.2024.e36023 　

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    Whether all obesity-related variants contribute to the onset of obesity or one or a few variants cause obesity in genetically heterogeneous populations remains obscure. Here, we investigated the genetic architecture of obesity by clustering the Japanese and British populations with obesity using obesity-related factors. In Step-1, we conducted a genome-wide association study (GWAS) with body mass index (BMI) as the outcome for eligible participants. In Step-2, we assigned participants with obesity (BMI ≥25 kg/m2) to five clusters based on obesity-related factors. Subsequently, participants from each cluster and those with a BMI <25 kg/m2 were combined. A GWAS was conducted for each cluster. Several previously identified obesity-related genes were verified in Step-1. Of the genes detected in Step-1, unique obesity-related genes were detected separately for each cluster in Step-2. Our novel findings suggest that a smaller sample size with increased homogeneity may provide insights into the genetic architecture of obesity.

  29. Association of olfactory and cognitive function test scores with hippocampal and amygdalar grey matter volume: a cross-sectional study

    Shuichi Sato, Takao Imaeda, Shunji Mugikura, Naoko Mori, Masaki Takanashi, Kazumi Hayakawa, Tomo Saito, Makiko Taira, Akira Narita, Mana Kogure, Ippei Chiba, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Ryosuke Ishiwata, Tomohiro Nakamura, Ikuko N. Motoike, Naoki Nakaya, Seizo Koshiba, Kengo Kinoshita, Shinichi Kuriyama, Soichi Ogishima, Fuji Nagami, Nobuo Fuse, Atsushi Hozawa

    Scientific Reports　14　(1)　2024/08/19

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-024-69726-4 　

    eISSN： 2045-2322

  30. The association of birth weight and current BMI on the risk of hypertension: the Tohoku medical megabank community-based cohort study. International-journal

    Hiromi Himuro, Mana Kogure, Naoki Nakaya, Tomohiro Nakamura, Rieko Hatanaka, Ippei Chiba, Kumi Nakaya, Naho Tsuchiya, Takumi Hirata, Masatsugu Orui, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Akira Uruno, Nobuo Fuse, Satoshi Nagaie, Soichi Ogishima, Mami Ishikuro, Taku Obara, Yoko Izumi, Masatoshi Saito, Shinichi Kuriyama, Atsushi Hozawa, Junichi Sugawara

    Hypertension research : official journal of the Japanese Society of Hypertension　2024/08/08

    DOI： 10.1038/s41440-024-01827-z 　

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    This study aimed to investigate the association of combination of birth weight and current body mass index (BMI) with the risk of hypertension in adulthood. This cross-sectional study used data from the Tohoku Medical Megabank Community-based Cohort Study conducted in Japan. A total of 10,688 subjects aged ≥20 years were eligible. We calculated the least square (LS) means of systolic blood pressure (SBP) and trend tests were performed to evaluate the linear relationships between birth weight categories and SBP. We also used a multivariate logistic regression analysis to assess the risk of hypertension associated with the combination of birth weight and current BMI. There was a statistically inverse association between birth weight and SBP in the 20-64 age group, but no significant association in the ≥65 age group. Low birth weight (LBW) with normal BMI group had a higher risk of hypertension than the normal or high birth weight groups with normal BMI. Furthermore, the group with LBW and BMI ≥25.0 kg/m2 was the highest risk for hypertension (adjusted odds ratio: 2.73; 95% CI, 2.04-3.65) compared to the reference group (birth weight 2500-3499 g and BMI 18.5-24.9 kg/m2). There was a significant association between LBW and subsequent risk of hypertension. In addition, participants with lower birth weights had a higher risk of hypertension than those with higher birth weights. However, even in participants with a lower birth weight, the risk of hypertension could be reduced when they maintained an optimal BMI.

  31. Body Mass Index and Risk of Colorectal Cancer Incidence and Mortality in Asia. International-journal

    Pedram Paragomi, Zhongjie Zhang, Sarah Krull Abe, Md Rashedul Islam, Md Shafiur Rahman, Eiko Saito, Xiao-Ou Shu, Bashir Dabo, Yen Thi-Hai Pham, Yu Chen, Yu-Tang Gao, Woon-Puay Koh, Norie Sawada, Reza Malekzadeh, Ritsu Sakata, Atsushi Hozawa, Jeongseon Kim, Seiki Kanemura, Chisato Nagata, San-Lin You, Hidemi Ito, Sue K Park, Jian-Min Yuan, Wen-Harn Pan, Wanqing Wen, Renwei Wang, Hui Cai, Shoichiro Tsugane, Akram Pourshams, Yumi Sugawara, Keiko Wada, Chien-Jen Chen, Isao Oze, Aesun Shin, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang, Hung N Luu

    JAMA network open　7　(8)　e2429494　2024/08/01

    DOI： 10.1001/jamanetworkopen.2024.29494 　

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    IMPORTANCE: The global burden of obesity is increasing, as are colorectal cancer (CRC) incidence and mortality. OBJECTIVES: To assess the association between body mass index (BMI) and risks of incident CRC and CRC-related death in the Asian population. DESIGN, SETTING, AND PARTICIPANTS: This cohort study includes data pooled from 17 prospective cohort studies included in The Asia Cohort Consortium. Cohort enrollment was conducted from January 1, 1984, to December 31, 2002. Median follow-up time was 15.2 years (IQR, 12.1-19.2 years). Data were analyzed from January 15, 2023, through January 15, 2024. EXPOSURE: Body mass index, calculated as weight in kilograms divided by height in meters squared. MAIN OUTCOMES AND MEASURES: The primary outcomes were CRC incidence and CRC-related mortality. The risk of events is reported as adjusted hazard ratios (AHRs) and 95% CIs for incident CRC and death from CRC using the Cox proportional hazards regression model. RESULTS: To assess the risk of incident CRC, 619 981 participants (mean [SD] age, 53.8 [10.1] years; 52.0% female; 11 900 diagnosed incident CRC cases) were included in the study, and to assess CRC-related mortality, 650 195 participants (mean [SD] age, 53.5 [10.2] years; 51.9% female; 4550 identified CRC deaths) were included in the study. A positive association between BMI and risk of CRC was observed among participants with a BMI greater than 25.0 to 27.5 (AHR, 1.09 [95% CI, 1.03-1.16]), greater than 27.5 to 30.0 (AHR, 1.19 [95% CI, 1.11-1.29]), and greater than 30.0 (AHR, 1.32 [95% CI, 1.19-1.46]) compared with those with a BMI greater than 23.0 to 25.0 (P < .001 for trend), and BMI was associated with a greater increase in risk for colon cancer than for rectal cancer. A similar association between BMI and CRC-related death risk was observed among participants with a BMI greater than 27.5 (BMI >27.5-30.0: AHR, 1.18 [95% CI, 1.04-1.34]; BMI >30.0: AHR, 1.38 [95% CI, 1.18-1.62]; P < .001 for trend) and was present among men with a BMI greater than 30.0 (AHR, 1.87 [95% CI, 1.49-2.34]; P < .001 for trend) but not among women (P = .15 for trend) (P = .02 for heterogeneity). CONCLUSIONS AND RELEVANCE: In this cohort study that included a pooled analysis of 17 cohort studies comprising participants across Asia, a positive association between BMI and CRC incidence and related mortality was found. The risk was greater among men and participants with colon cancer. These findings may have implications to better understand the burden of obesity on CRC incidence and related deaths in the Asian population.

  32. Fractional exhaled nitric oxide distribution and its relevant factors in the general adult population and its healthy subpopulation. International-journal

    Mitsuhiro Yamada, Masato Takase, Kumi Nakaya, Tomohiro Nakamura, Mana Kogure, Naoki Nakaya, Naoya Fujino, Tsutomu Tamada, Chikashi Iwasaki, Manami Suzuki, Shuichiro Matsumoto, Nobuo Fuse, Akira Uruno, Kazuki Kumada, Soichi Ogishima, Shinichi Kuriyama, Masakazu Ichinose, Hisatoshi Sugiura, Atsushi Hozawa

    The journal of allergy and clinical immunology. Global　3　(3)　100253-100253　2024/08

    DOI： 10.1016/j.jacig.2024.100253 　

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    BACKGROUND: Measurement of fractional exhaled nitric oxide (Feno) has been used in the diagnosis and management of asthma. Understanding the distribution of Feno in a larger resident population and its "healthy" subpopulation would contribute to the interpretation of Feno in clinical practice. OBJECTIVE: This study aimed to investigate the distribution and its associated factors in the adult population and its healthy subpopulations. METHODS: We conducted a cross-sectional study of 8,638 men and 17,288 women aged 20 years or older living in Miyagi prefecture, Japan. We investigated the distribution of Feno and its associated factors in all subjects, a subpopulation with no history of upper and lower airway diseases (healthy subpopulation 1), and a subpopulation with no history of upper and lower airway diseases, normal lung function, and no positivity for other biomarkers of type 2 inflammation (healthy subpopulation 2). RESULTS: The distribution of Feno in healthy subpopulations, especially in healthy subpopulation 2 (median [interquartile range], 17 [12-23] with 95th percentile of 36 ppb) was lower than in all subjects (19 [13-26] ppb with 95th percentile of 47 ppb). In healthy subpopulation 1, 10.3% had elevated Feno (≥35 ppb), and elevated Feno was positively associated with factors including obstructive ventilatory defect, blood eosinophilia, house dust mite-specific IgE positivity, and history of hypertension. Male sex was associated with elevated Feno in all subjects and healthy subpopulations. CONCLUSION: The distribution of Feno in the healthy subpopulation supports the validity of the criteria (≥35 ppb) currently used in Japan for the diagnosis of asthma.

  33. How Healthy Lifestyle Habits Have Interacted with SARS-CoV-2 Infection and the Effectiveness of COVID-19 Vaccinations: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

    Masatsugu Orui, Taku Obara, Mami Ishikuro, Aoi Noda, Genki Shinoda, Keiko Murakami, Tomohiro Nakamura, Hirohito Metoki, Soichi Ogishima, Yoko Izumi, Naoki Nakaya, Atsushi Hozawa, Tadashi Ishii, Fuji Nagami, Masayuki Yamamoto, Shinichi Kuriyama

    JMA journal　7　(3)　353-363　2024/07/16

    DOI： 10.31662/jmaj.2024-0043 　

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    INTRODUCTION: To examine the interaction between lifestyle habits and the COVID-19 vaccinations for preventing SARS-CoV-2 infection, we analyzed 11,016 adult participants registered in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. METHODS: Lifestyle variables, including regular exercise, smoking and drinking habits, sleep status, body mass index, and daily breakfast consumption, were assessed from 2014 to 2019 using baseline questionnaires. Information on SARS-CoV-2 infection and the COVID-19 vaccination were also collected from March 2020 to May 2023. The study period was divided into two in the postvaccination phase: the first period (the beginning of the vaccination program) and the second period (the fourth shot onward). RESULTS: In the Cox proportional-hazards model analysis, the five-time vaccinations group showed a significantly lower risk of SARS-CoV-2 infection adjusted age, sex, underlying health condition, and lifestyle variables (hazard ratio [HR] 0.81, 95% confidence interval [CI] 0.76-0.86). Logistic regression analysis revealed that a higher number of vaccinations was significantly associated with a low risk of SARS-CoV-2 infection regardless of lifestyle habits (three times in the first period: odds ratio [OR] 0.19, 95% CI 0.15-0.24; five times in the second period: OR 0.07, 95% CI 0.05-0.11 vs. none). Regarding lifestyle habits, the risk reduction in those who had sleep satisfaction (OR 0.12, 95% CI 0.08-0.18) was slightly larger than in those who had sleep dissatisfaction (OR 0.23, 95% CI 0.17-0.32) in the group with the highest number of vaccinations in the first period; however, this interaction was hardly confirmed in the second period when the number of infected cases significantly increased. CONCLUSIONS: Our findings indicated that a higher number of COVID-19 vaccinations was associated with reduced risk of SARS-CoV-2 infection; otherwise, we may need to understand the advantages and limitations of a healthy lifestyle for preventing infection depending on the situation with vaccinations and infection spreading.

  34. Urgent Notification Intervention of Home Blood Pressure in Cohort Studies of the Tohoku Medical Megabank Project.

    Eiichi N Kodama, Makiko Taira, Hideyasu Kiyomoto, Tomohiro Nakamura, Satoshi Nagaie, Shinichi Kuriyama, Atsushi Hozawa, Junichi Sugawara, Fuji Nagami, Akira Uruno, Jun Nakaya, Hirohito Metoki, Masaki Sakaida, Masahiro Kikuya, Yoichi Suzuki, Kiyoshi Ito, Yohei Hamanaka, Kichiya Suzuki, Shigeo Kure, Nobuo Yaegashi, Nobuo Fuse, Ritsuko Shimizu, Masayuki Yamamoto

    JMA journal　7　(3)　342-352　2024/07/16

    DOI： 10.31662/jmaj.2023-0215 　

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    INTRODUCTION: The Tohoku Medical Megabank (TMM) was established for creative reconstruction from the Great East Japan Earthquake and tsunami in 2011. Two prospective genome cohort studies in Miyagi prefecture have successfully recruited approximately 127,000 participants. The health status of these individuals was evaluated at the initial recruitment, and follow-up health checkups have been conducted every 5 years. During these health checkups, unexpected critical values were encountered, which prompted us to develop an urgent notification system. METHODS: We analyzed the frequency of critical values observed in home blood pressure (HBP) test in an urgent notification office (UNO). We returned the critical values by urgent notification before the notifications of regular results. In addition, the impact of the TMM urgent notification on the participants was evaluated. RESULTS: We issued urgent notifications of the critical values of extremely high HBP. Of the 21,061 participants who underwent HBP measurements, 256 (1.2%) met the criteria for urgent notification. It was found that abnormalities in blood sugar levels, renal function, and lipid values were frequently concurrent with the abnormal HBP readings. Annual questionnaires administered after the urgent notification, approximately 60% of those went to hospitals or clinics. CONCLUSIONS: The urgent notification system for hypertensive emergency with HBP in the TMM was well accepted by the participants and encouraged them to seek medical care. The system has been useful in addressing the prolonged healthcare problems and in promoting health care in large-scale disaster damaged areas.

  35. Depressive symptoms as risk factors for the onset of home hypertension: a prospective cohort study. International-journal

    Sayuri Tokioka, Naoki Nakaya, Rieko Hatanaka, Kumi Nakaya, Mana Kogure, Ippei Chiba, Kotaro Nochioka, Hirohito Metoki, Takahisa Murakami, Michihiro Satoh, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension　2024/07/10

    DOI： 10.1038/s41440-024-01790-9 　

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    Depression is comorbid with somatic diseases; however, the relationship between depressive symptoms and hypertension (HT), a risk factor for cardiovascular events, remains unclear. Home blood pressure (BP) is more reproducible and accurately predictive of cardiovascular diseases than office BP. Therefore, we focused on home BP and investigated whether depressive symptoms contributed to the future onset of home HT. This prospective cohort study used data from the Tohoku Medical Megabank Community-Cohort Study (conducted in the Miyagi Prefecture, Japan) and included participants with home normotension (systolic blood pressure (SBP) < 135 mmHg and diastolic blood pressure (DBP) < 85 mmHg). Depressive symptoms were evaluated using the Center for Epidemiologic Studies Depression Scale-Japanese version at the baseline survey. In the secondary survey, approximately 4 years later, the onset of home HT was evaluated (SBP ≥ 135 mmHg or DBP ≥ 85 mmHg) and was compared in participants with and without depressive symptoms. Of the 3 082 (mean age: 54.2 years; females: 80.9%) participants, 729 (23.7%) had depressive symptoms at the baseline survey. During the 3.5-year follow-up, 124 (17.0%) and 388 (16.5%) participants with and without depressive symptoms, respectively, developed home HT. Multivariable adjusted odds ratios were 1.37 (95% confidence interval (CI): 1.02-1.84), 1.18 (95% CI: 0.86-1.61), and 1.66 (95% CI: 1.17-2.36) for home, morning, and evening HT, respectively. This relationship was consistent in the subgroup analyses according to age, sex, BP pattern, and drinking habit. Depressive symptoms increased the risk of new-onset home HT, particularly evening HT, among individuals with home normotension. This prospective cohort study revealed that depressive symptoms are risk factors for new-onset home hypertension, particularly evening hypertension among individuals with home normotension. Assessing home blood pressure in individuals with depressive symptoms is important for the prevention of hypertension and concomitant cardiovascular diseases.

  36. Number of teeth and functional disability in community-dwelling older adults. International-journal

    Takamasa Komiyama, Takashi Ohi, Yoshitada Miyoshi, Mana Kogure, Naoki Nakaya, Atsushi Hozawa, Ichiro Tsuji, Makoto Watanabe, Yoshinori Hattori

    Gerodontology　2024/07/10

    DOI： 10.1111/ger.12775 　

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    INTRODUCTION: This study determined whether tooth loss was associated with the development of functional disability and estimated the population attributable fraction (PAF) of functional disability due to tooth loss, along with risk factors for functional disability such as physical function and cognitive impairment. METHODS: The participants were 838 community-dwelling older adults aged ≥70 years living in the Tsurugaya district in Japan in 2003. The exposure variable was the number of remaining teeth (counted by trained dentists). Other variables were age, sex, depressive symptoms, cognitive impairment, educational attainment, physical function and social support. The Cox proportional hazards model was applied to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of the incidence of functional disability for each risk factor, such as tooth loss. The functional disability PAF due to tooth loss was estimated, and risk factors for functional disability were identified. RESULTS: In total, 619 (73.9%) participants developed functional disability during follow-up. A multivariable model showed that those with <20 teeth (HR, 1.28; 95% CI, 1.08-1.53) were more likely to develop functional disability than those with 20 teeth or more. PAF estimation for functional disability was shown to have decreasing values in the following order: age, female sex, tooth loss and reduced physical function. CONCLUSIONS: Tooth loss was associated with the development of functional disability in community-dwelling older Japanese adults. While retaining teeth may be a potential strategy for avoiding functional disability, clinical studies on the effect of dental treatment on preventing functional disability are warranted.

  37. Identifying critical age and gender-based metabolomic shifts in a Japanese population of the Tohoku Medical Megabank cohort. International-journal

    Miyuki Sakurai, Ikuko N Motoike, Eiji Hishinuma, Yuichi Aoki, Shu Tadaka, Mana Kogure, Masatsugu Orui, Mami Ishikuro, Taku Obara, Naoki Nakaya, Kazuki Kumada, Atsushi Hozawa, Shinichi Kuriyama, Masayuki Yamamoto, Seizo Koshiba, Kengo Kinoshita

    Scientific reports　14　(1)　15681-15681　2024/07/08

    DOI： 10.1038/s41598-024-66180-0 　

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    Understanding the physiological changes associated with aging and the associated disease risks is essential to establish biomarkers as indicators of biological aging. This study used the NMR-measured plasma metabolome to calculate age-specific metabolite indices. In doing so, the scope of the study was deliberately simplified to capture general trends and insights into age-related changes in metabolic patterns. In addition, changes in metabolite concentrations with age were examined in detail, with the period from 55-59 to 60-64 years being a period of significant metabolic change, particularly in men, and from 45-49 to 50-54 years in females. These results illustrate the different variations in metabolite concentrations by sex and provide new insights into the relationship between age and metabolic diseases.

  38. A principal component analysis of metabolome and cognitive decline among Japanese older adults: cross-sectional analysis using Tohoku Medical Megabank Cohort Study.

    Sakura Kiuchi, Kumi Nakaya, Upul Cooray, Kenji Takeuchi, Ikuko N Motoike, Naoki Nakaya, Yasuyuki Taki, Seizo Koshiba, Shunji Mugikura, Ken Osaka, Atsushi Hozawa

    Journal of epidemiology　2024/07/06

    DOI： 10.2188/jea.JE20240099 　

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    BackgroundDementia is the leading cause of disability and imposes a significant burden on society. Previous studies have suggested an association between metabolites and cognitive decline. Although the metabolite composition differs between Western and Asian populations, studies targeting Asian populations remain scarce.MethodsThis cross-sectional study used data from a cohort survey of community-dwelling older adults aged ≥ 60 years living in Miyagi, Japan, conducted by Tohoku Medical Megabank Organization between 2013 and 2016. Forty-three metabolite variables quantified using nuclear magnetic resonance spectroscopy were used as explanatory variables. Dependent variable was the presence of cognitive decline (≤ 23 points), assessed by the Mini-Mental State Examination. Principal component (PC) analysis was performed to reduce the dimensionality of metabolite variables, followed by logistic regression analysis to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for cognitive decline.ResultsA total of 2,940 participants were included (men: 49.0%, mean age: 67.6 years). Among them, 1.9% showed cognitive decline. The first 12 PC components (PC1-PC12) accounted for 71.7% of the total variance. Multivariate analysis showed that PC1, which mainly represented essential amino acids, was associated with lower odds of cognitive decline (OR = 0.89; 95% CI, 0.80-0.98). PC2, which mainly included ketone bodies, was associated with cognitive decline (OR = 1.29; 95% CI, 1.11-1.51). PC3, which included amino acids, was associated with lower odds of cognitive decline (OR = 0.81; 95% CI, 0.66-0.99).ConclusionAmino acids are protectively associated with cognitive decline, whereas ketone metabolites are associated with higher odds of cognitive decline.

  39. 独居・同居と婚姻状態の組み合わせと総死亡の関連 東北メディカル・メガバンク地域住民コホート調査

    事崎 由佳, 中谷 久美, 中谷 直樹, 小暮 真奈, 千葉 一平, 畑中 里衣子, 高瀬 雅仁, 時岡 紗由理, 永家 聖, 那須 崇人, 大桃 秀樹, 寳澤 篤, 丹野 高三

    東北公衆衛生学会誌　(73)　23-23　2024/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  40. Associations of combined genetic and lifestyle risks with hypertension and home hypertension. International-journal

    Masato Takase, Takumi Hirata, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Akira Narita, Hirohito Metoki, Michihiro Satoh, Taku Obara, Mami Ishikuro, Hisashi Ohseto, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

    Hypertension research : official journal of the Japanese Society of Hypertension　2024/06/24

    DOI： 10.1038/s41440-024-01705-8 　

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    No study, to our knowledge, has constructed a polygenic risk score based on clinical blood pressure and investigated the association of genetic and lifestyle risks with home hypertension. We examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. In a cross-sectional study of 7027 Japanese individuals aged ≥20 years, we developed a lifestyle score based on body mass index, alcohol consumption, physical activity, and sodium-to-potassium ratio, categorized into ideal, intermediate, and poor lifestyles. A polygenic risk score was constructed with the target data (n = 1405) using publicly available genome-wide association study summary statistics from BioBank Japan. Using the test data (n = 5622), we evaluated polygenic risk score performance and examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. Hypertension and home hypertension were defined as blood pressure measured at a community-support center ≥140/90 mmHg or at home ≥135/85 mmHg, respectively, or self-reported treatment for hypertension. In the test data, 2294 and 2322 participants had hypertension and home hypertension, respectively. Both polygenic risk and lifestyle scores were independently associated with hypertension and home hypertension. Compared with those of participants with low genetic risk and an ideal lifestyle, the odds ratios for hypertension and home hypertension in the low genetic risk and poor lifestyle group were 1.94 (95% confidence interval, 1.34-2.80) and 2.15 (1.60-2.90), respectively. In summary, lifestyle is important to prevent hypertension; nevertheless, participants with high genetic risk should carefully monitor their blood pressure despite a healthy lifestyle.

  41. Genetic Risk, Healthy Lifestyle Adherence, and Risk of Developing Diabetes in the Japanese Population.

    Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Akira Narita, Taku Obara, Mami Ishikuro, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Koichi Matsuda, Yoko Izumi, Kengo Kinoshita, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

    Journal of atherosclerosis and thrombosis　2024/06/22

    DOI： 10.5551/jat.64906 　

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    AIM: This study examined the relationship between genetic risk, healthy lifestyle, and risk of developing diabetes. METHODS: This prospective cohort study included 11,014 diabetes-free individuals ≥ 20 years old from the Tohoku Medical Megabank Community-based cohort study. Lifestyle scores, including the body mass index, smoking, physical activity, and gamma-glutamyl transferase (marker of alcohol consumption), were assigned, and participants were categorized into ideal, intermediate, and poor lifestyles. A polygenic risk score (PRS) was constructed based on the type 2 diabetes loci from the BioBank Japan study. A multiple logistic regression model was used to estimate the association between genetic risk, healthy lifestyle, and diabetes incidence and to calculate the area under the receiver operating characteristic curve (AUROC). RESULT: Of the 11,014 adults included (67.8% women; mean age [standard deviation], 59.1 [11.3] years old), 297 (2.7%) developed diabetes during a mean 4.3 (0.8) years of follow-up. Genetic and lifestyle score is independently associated with the development of diabetes. Compared with the low genetic risk and ideal lifestyle groups, the odds ratio was 3.31 for the low genetic risk and poor lifestyle group. When the PRS was integrated into a model including the lifestyle and family history, the AUROC significantly improved to 0.719 (95% confidence interval [95% CI]: 0.692-0.747) compared to a model including only the lifestyle and family history (0.703 [95% CI, 0.674-0.732]). CONCLUSION: Our findings indicate that adherence to a healthy lifestyle is important for preventing diabetes, regardless of genetic risk. In addition, genetic risk might provide information beyond lifestyle and family history to stratify individuals at high risk of developing diabetes.

  42. リアルワールドデータを用いたDPP-4阻害薬服薬者と非服薬者の腎予後の比較

    橋本 英明, 佐藤 倫広, 村上 任尚, 遠山 真弥, 中山 晋吾, 小原 拓, 中谷 直樹, 森 建文, 寳澤 篤

    日本腎臓学会誌　66　(4)　616-616　2024/06

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  43. リアルワールドデータを用いたDPP-4阻害薬服薬者と非服薬者の腎予後の比較

    橋本 英明, 佐藤 倫広, 村上 任尚, 遠山 真弥, 中山 晋吾, 小原 拓, 中谷 直樹, 森 建文, 寳澤 篤

    日本腎臓学会誌　66　(4)　616-616　2024/06

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  44. Relationship between parity and the prevalence of chronic kidney disease in Japan considering hypertensive disorders of pregnancy and body mass index. International-journal

    Hongxin Wang, Noriyuki Iwama, Keiichi Yuwaki, You Nakamichi, Hirotaka Hamada, Hasumi Tomita, Kazuma Tagami, Rie Kudo, Natsumi Kumagai, Hirohito Metoki, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Yaegashi, Masatoshi Saito

    BMC nephrology　25　(1)　166-166　2024/05/17

    DOI： 10.1186/s12882-024-03604-z 　

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    BACKGROUND: Global studies exploring the relationship between parity and chronic kidney disease (CKD) are scarce. Furthermore, no study has examined the relationship between parity and CKD in Japan. Therefore, this study aimed to examine the relationship between parity and the prevalence of CKD in a Japanese population, considering the clinical history of hypertensive disorders of pregnancy (HDP) and current body mass index (BMI) based on menopausal status. METHODS: This cross-sectional study included 26,945 Japanese multiparous women (5,006 premenopausal and 21,939 postmenopausal women) and 3,247 nulliparous women (1,599 premenopausal and 1,648 postmenopausal women). Participants were divided into two groups based on their menopausal status (premenopausal and postmenopausal women). The relationship between parity and the prevalence of CKD was evaluated using a multiple logistic regression model adjusted for several covariates, including a clinical history of HDP and current BMI. RESULTS: The relationship between parity and the prevalence of CKD was not statistically significant in either premenopausal or postmenopausal multiparous women. A clinical history of HDP was significantly associated with an increased risk of CKD in premenopausal and postmenopausal multiparous women. However, the relationship between a clinical history of HDP and CKD in premenopausal women was weakened after adjusting for current BMI. Furthermore, the current BMI was significantly associated with an increased risk of CKD in both premenopausal and postmenopausal women. CONCLUSIONS: Parity is not significantly associated with the prevalence of CKD in premenopausal and postmenopausal multiparous women. A clinical history of HDP is a risk factor for CKD in both premenopausal and postmenopausal women. Current BMI is also associated with an increased risk of CKD in premenopausal and postmenopausal women. Therefore, continuous surveillance and preventive measures against CKD should be provided to women with a clinical history of HDP. In addition, maintaining an appropriate body weight is beneficial in reducing the risk of CKD.

  45. Associations between housing and psychological damage by earthquake and modifiable risk factors for dementia in general older adults: Tohoku Medical Megabank community-based cohort study.

    Ippei Chiba, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Sayuri Tokioka, Tomohiro Nakamura, Satoshi Nagaie, Nobuo Fuse, Taku Obara, Yuka Kotozaki, Kozo Tanno, Shinichi Kuriyama, Atsushi Hozawa

    Geriatrics & gerontology international　2024/05/03

    DOI： 10.1111/ggi.14867 　

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    AIM: To evaluate the association between housing and psychological damage caused by the Great East Japan Earthquake (GEJE) and modifiable risk factors (MRFs) of dementia for general population of older adults. METHODS: This cross-sectional study enrolled 29 039 community-dwelling older adults (mean age 69.1 ± 2.9 years, 55.5% women). We evaluated disaster-related damage (by complete or not complete housing damage) and psychological damage (by post-traumatic stress reaction [PTSR]) after the GEJE using a self-report questionnaire. MRFs encompassed the presence of depression, social isolation, physical inactivity, smoking, and diabetes. We examined the association between disaster-related damage and MRFs using ordinary least squares and modified Poisson regression models adjusted for sociodemographic and health status variables. RESULTS: Complete housing damage and PTSR were identified in 2704 (10.0%) and 855 (3.2%) individuals, respectively. The number of MRFs was significantly larger for the individuals with complete housing damage (β = 0.23; 95% confidence interval [CI]: 0.19-0.27) and PTSR (β = 0.60; 95% CI: 0.53-0.67). Prevalence ratios (PRs) for depression and physical inactivity were higher in individuals with complete housing damage. The PRs for all domains of the MRFs were significantly higher in individuals with PTSR. CONCLUSIONS: Housing and psychological damage caused by the GEJE were associated with an increased risk factor of dementia. To attenuate the risk of dementia, especially among older victims who have experienced housing and psychological damage after a disaster, multidimensional support across various aspects of MRFs is required. Geriatr Gerontol Int 2024; ••: ••-••.

  46. Factors Associated With the Prevalence of Irritable Bowel Syndrome: The Miyagi Part of the Tohoku Medical Megabank Project Community-based Cohort Study. International-journal

    Kumi Nakaya, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Satoshi Nagaie, Tomohiro Nakamura, Motoyori Kanazawa, Soichi Ogishima, Nobuo Fuse, Shin Fukudo, Atsushi Hozawa

    Journal of neurogastroenterology and motility　30　(2)　208-219　2024/04/30

    DOI： 10.5056/jnm23090 　

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    BACKGROUND/AIMS: The objective of this research is to examine factors related to irritable bowel syndrome (IBS) prevalence in a large population-based study. METHODS: A cross-sectional study was conducted with participants in the Miyagi part of the Tohoku Medical Megabank Project Community-Based cohort study who completed the Rome II Modular Questionnaire. Multivariate odds ratios (ORs) for the presence of IBS and 95% confidence intervals (95% CIs) for the reference group were calculated for each factor. Additionally, a stratified analysis was performed by sex and age group (20-49 years, 50-64 years, and ≥ 65 years). RESULTS: Among 16 252 participants, 3025 (18.6%) had IBS, comprising 750 men (15.5%) and 2275 women (19.9%). Multivariate ORs for the presence of IBS decreased significantly with each year of age (OR, 0.98; 95% CI, 0.98-0.99). Moreover, compared with the reference group, ORs for the presence of IBS were significantly higher in individuals whose home was partially damaged by the Great East Japan Earthquake, those with < 16 years of education, those who spent less time walking, those with high perceived stress (1.77, 1.57-2.01), those with high psychological distress (1.58, 1.36-1.82), and those with high symptoms of depression (1.76, 1.60-1.94). In stratified analyses, a significant relationship was found between psychological factors and IBS prevalence in all sex and age groups. CONCLUSIONS: This large cross-sectional population-based cohort study identified several factors associated with IBS prevalence. Psychological factors were significantly associated with IBS prevalence across all age groups and sexes.

  47. Combined effects of blood pressure and glucose status on the risk of chronic kidney disease. International-journal

    Maya Toyama, Michihiro Satoh, Shingo Nakayama, Hideaki Hashimoto, Tomoko Muroya, Takahisa Murakami, Takuo Hirose, Taku Obara, Naoki Nakaya, Takefumi Mori, Takayoshi Ohkubo, Yutaka Imai, Atsushi Hozawa, Hirohito Metoki

    Hypertension research : official journal of the Japanese Society of Hypertension　2024/04/26

    DOI： 10.1038/s41440-024-01683-x 　

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    This study aimed to assess the combined effects of blood pressure (BP) and glucose status on chronic kidney disease (CKD) incidence in young and middle-aged adults. We examined data from 1,297,341 Japanese individuals aged <60 years (60.1% men; mean age 41.4 ± 9.3 years) with no history of CKD at baseline. The interval-censored Cox proportional hazards model with covariates was used. During a median follow-up period of 2.1 years, new onset CKD (estimated glomerular filtration rate <60 ml/min/1.73 m2 and/or proteinuria) occurred in 80,187 participants. In participants without antihypertensive treatment (AHT), the adjusted hazard ratios (95% confidence interval) per 1-standard deviation, that is, 15 mmHg increase in systolic BP for CKD incidence, were 1.08 (1.07-1.09), 1.12 (1.10-1.13), and 1.15 (1.12-1.18) in normoglycemia, borderline glycemia, and diabetes groups, respectively. These ratios were significantly higher in the borderline glycemia and diabetes groups compared with those in the normoglycemia group (interaction p < 0.0001). The interaction between BP and borderline glycemia was evident when the outcome definition was restricted to proteinuria. In participants under AHT, systolic BP was most strongly associated with CKD risk in the diabetes group, although no significant interaction was observed. High BP and high glucose status may synergistically increase the incidence of CKD. Strict BP management may play an important role in the early prevention of CKD in individuals with worse glucose status within the young and middle-aged population. This large-scale longitudinal cohort study showed high BP and diabetes synergistically increased the risk of CKD in individuals without AHT. Strict BP management may play an important role in the early prevention of CKD in individuals with worse glucose status within the young and middle-aged population.

  48. GWAS meta-analysis of kidney function traits in Japanese populations.

    Asahi Hishida, Masahiro Nakatochi, Yoichi Sutoh, Shiori Nakano, Yukihide Momozawa, Akira Narita, Kozo Tanno, Atsushi Shimizu, Atsushi Hozawa, Kengo Kinoshita, Taiki Yamaji, Atsushi Goto, Mitsuhiko Noda, Norie Sawada, Hiroaki Ikezaki, Mako Nagayoshi, Megumi Hara, Sadao Suzuki, Teruhide Koyama, Chihaya Koriyama, Sakurako Katsuura-Kamano, Aya Kadota, Kiyonori Kuriki, Masayuki Yamamoto, Makoto Sasaki, Motoki Iwasaki, Keitaro Matsuo, Kenji Wakai

    Journal of epidemiology　2024/04/06

    DOI： 10.2188/jea.JE20230281 　

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    BACKGROUND: Genetic epidemiological evidence for the kidney function traits in East Asian population including Japanese remain still relatively unclarified. Especially, the number of GWASs for kidney traits reported still remains limited, and the sample size of each independent study is relatively small. Given the genetic variability between ancestries/ethnicities, implementation of GWAS with sufficiently large sample sizes in specific population of Japanese is considered meaningful. METHODS: We conducted the GWAS meta-analyses of kidney traits by leveraging the GWAS summary data of the representative large genome cohort studies with about 200,000 Japanese participants (n = 202,406 for estimated glomerular filtration rate [eGFR] and n = 200,845 for serum creatinine [SCr]). RESULTS: In the present GWAS meta-analysis, we identified 110 loci with 169 variants significantly associated with eGFR (on chromosomes 1-13 and 15-22; p < 5×10-8), whereas we also identified 112 loci with 176 variants significantly associated with SCr (on chromosomes 1-22; p < 5×10-8), of which one locus (more than 1Mb distant from known loci) with one variant (CD36 rs146148222 on chromosome 7) for SCr was considered as the truly novel finding. CONCLUSIONS: The present GWAS meta-analysis of largest genome cohort studies in Japanese provided some original genomic loci associated with kidney function in Japanese, which may contribute to the possible development of personalized prevention of kidney diseases based on genomic information in the near future.

  49. 糖尿病の家族歴、遺伝要因、生活習慣の組み合わせと糖尿病発症の関連 東北メディカル・メガバンク地域住民コホート調査

    高瀬 雅仁, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 時岡 紗由理, 平田 匠, 田宮 元, 寳澤 篤

    日本循環器病予防学会誌　59　(2)　127-127　2024/04

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

    eISSN： 2759-5323

  50. 家庭血圧と難聴の有無の関連 東北メディカル・メガバンク地域住民コホート調査

    佐竹 芽久美, 千葉 一平, 高瀬 雅仁, 畑中 里衣子, 中谷 久美, 小暮 真奈, 時岡 紗由理, 中谷 直樹, 寳澤 篤

    日本循環器病予防学会誌　59　(2)　128-128　2024/04

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

    eISSN： 2759-5323

  51. 平日と休日の睡眠時間の差と家庭高血圧との関連

    野路 慶明, 畑中 里衣子, 中谷 直樹, 小暮 真奈, 中谷 久美, 千葉 一平, 時岡 紗由理, 中村 智洋, 栗山 進一, 寳澤 篤

    日本循環器病予防学会誌　59　(2)　127-127　2024/04

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  52. 認知機能低下予測のための血圧日間変動指標の探索 大迫研究

    佐藤 倫広, 目時 弘仁, 村上 任尚, 辰巳 友佳子, 原 梓, 野村 恭子, 浅山 敬, 菊谷 昌浩, 寳澤 篤, 大久保 孝義

    日本循環器病予防学会誌　59　(2)　130-130　2024/04

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  53. [Development of a new method for assessing the availability of low-sodium foods in Japan].

    Hitomi Hayabuchi, Yukari Takemi, Masanori Ohta, Ikuko Sakata, Keiko Sakaguchi, Akiko Kubo, Katsushi Yoshita, Kaori Kitaoka, Yukiko Okami, Takayoshi Ohkubo, Tomonori Okamura, Koichi Node, Katsuyuki Miura

    [Nihon koshu eisei zasshi] Japanese journal of public health　2024/03/29

    DOI： 10.11236/jph.23-094 　

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    Objectives Food environment improvement involving salt reduction requires improving access to and labeling low-sodium foods. Assessing the implementation status of these measures is also necessary. However, to date, no established methods exist for assessing the availability of low-sodium foods in communities. In this study, we aimed to devise a survey on the availability of low-sodium foods as a community food environment assessment method in order to establish common assessment methods, criteria, and practical measures, as well as standardization nationwide.Methods A preliminary survey on the availability of low-sodium foods was conducted in Kitakyushu City in four stores with nationwide representation. Consent for providing information on handled product lists was obtained. The on-site lists collected through direct investigation by surveyors were compared with the handled product lists provided by the stores and analyzed to identify survey challenges and examine feasibility and the potential for accuracy. The definition of low-sodium foods, which emerged as a challenge in the preliminary survey, was confirmed. Preliminary survey data were carefully reviewed to establish classification criteria for low-sodium foods and create a low-sodium food list to serve as a reference for on-site surveys. Forms for recording the results of on-site surveys and a survey manual were developed. Registered dietitians conducted on-site surveys using the manual to confirm its applicability.Results The preliminary survey results revealed that the on-site lists had fewer omissions and greater feasibility than store-provided lists. After clearly defining low-sodium foods, we established classification criteria (three major categories, seven subcategories, and 37 minor categories) considering the ease of on-site investigations and purchases. Three forms for recording survey results were developed, including a standard input form allowing detailed documentation of the availability of individual low-sodium foods, an aggregation form for a quantitative assessment of low-sodium foods availability, and a display form visualizing the availability of low-sodium foods by store. Furthermore, a survey manual was developed explaining the purpose and approach of the low-sodium foods availability survey, definition and classification criteria for low-sodium foods, and the three forms for recording survey results. Findings indicated that all registered dietitians could conduct on-site surveys using the manual and successfully collect and organize data.Conclusion On-site surveys using the manual and documentation forms enabled easy and accurate assessments of low-sodium foods availability. Thus, this standardized method to assess the availability of low-sodium foods could be a food environment assessment method for regional salt reduction initiatives.

  54. Association of female reproductive and hormonal factors with gallbladder cancer risk in Asia: A pooled analysis of the Asia Cohort Consortium. International-journal

    Aesun Shin, Sooyoung Cho, Sarah Krull Abe, Md Rashedul Islam, Md Shafiur Rahman, Eiko Saito, Sayada Zartasha Kazmi, Ryoko Katagiri, Melissa Merritt, Ji-Yeob Choi, Xiao-Ou Shu, Norie Sawada, Akiko Tamakoshi, Woon-Puay Koh, Ritsu Sakata, Atsushi Hozawa, Jeongseon Kim, Sue K Park, Sun-Seog Kweon, Wanqing Wen, Shoichiro Tsugane, Takashi Kimura, Jian-Min Yuan, Seiki Kanemura, Yumi Sugawara, Min-Ho Shin, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang

    International journal of cancer　2024/03/13

    DOI： 10.1002/ijc.34916 　

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    The female predominance of gallbladder cancer (GBC) has led to a hypothesis regarding the hormone-related aetiology of GBC. We aimed to investigate the association between female reproductive factors and GBC risk, considering birth cohorts of Asian women. We conducted a pooled analysis of 331,323 women from 12 cohorts across 4 countries (China, Japan, Korea, and Singapore) in the Asia Cohort Consortium. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) to assess the association between reproductive factors (age at menarche, parity, age at first delivery, breastfeeding, and age at menopause) and GBC risk. We observed that a later age at menarche was associated with an increased risk of GBC (HR 1.4, 95% CI 1.16-1.70 for 17 years and older vs. 13-14 years), especially among the cohort born in 1940 and later (HR 2.5, 95% CI 1.50-4.35). Among the cohort born before 1940, women with a later age at first delivery showed an increased risk of GBC (HR 1.56, 95% CI 1.08-2.24 for 31 years of age and older vs. 20 years of age and younger). Other reproductive factors did not show a clear association with GBC risk. Later ages at menarche and at first delivery were associated with a higher risk of GBC, and these associations varied by birth cohort.

  55. Association of physiological factors with grip and leg extension strength: tohoku medical megabank community-based cohort study. International-journal

    Yoshiaki Noji, Rieko Hatanaka, Naoki Nakaya, Mana Kogure, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Tomohiro Nakamura, Naho Tsuchiya, Haruki Momma, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Ryoichi Nagatomi, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

    BMC public health　24　(1)　714-714　2024/03/05

    DOI： 10.1186/s12889-024-18244-z 　

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    BACKGROUND: Upper and lower extremity muscle strength can be used to predict health outcomes. However, the difference between the relation of upper extremity muscle and of lower extremity muscle with physiological factors is unclear. This study aimed to evaluate the association between physiological data and muscle strength, measured using grip and leg extension strength, among Japanese adults. METHODS: We conducted a cross-sectional study of 2,861 men and 6,717 women aged ≥ 20 years living in Miyagi Prefecture, Japan. Grip strength was measured using a dynamometer. Leg extension strength was measured using a hydraulic isokinetic leg press machine. Anthropometry and physiological data, including blood pressure, calcaneal ultrasound bone status, pulmonary function, carotid echography, and blood information, were assessed. We used a general linear model adjusted for age, body composition, and smoking status to evaluate the association between muscle strength and physiological factors. RESULTS: Grip and leg extension strength were positively associated with bone area ratio, vital capacity, forced vital capacity, forced expiratory volume in one second, and estimated glomerular filtration rate, and negatively associated with waist circumference and percentage body fat mass in both the sexes. Diastolic blood pressure was positively associated with grip strength in both the sexes and leg extension strength in men, but not women. High-density lipoprotein cholesterol and red blood cell counts were positively associated with grip and leg extension strength in women, but not men. In both the sexes, pulse rate, total cholesterol, and uric acid were consistently associated with only leg extension strength, but not grip strength. In women, glycated hemoglobin demonstrated negative and positive associations with grip and leg extension strength, respectively. CONCLUSIONS: Grip and leg extension strength demonstrated similar associations with anthropometry, pulmonary function, and estimated glomerular filtration rate, but the associations with the other factors were not always consistent.

  56. Dietary habits and plasma lipid concentrations in a general Japanese population. International-journal

    Mitsuharu Sato, Eiji Hishinuma, Naomi Matsukawa, Yoshiko Shima, Daisuke Saigusa, Ikuko N Motoike, Mana Kogure, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Masayuki Yamamoto, Seizo Koshiba, Kengo Kinoshita

    Metabolomics : Official journal of the Metabolomic Society　20　(2)　34-34　2024/03/05

    DOI： 10.1007/s11306-024-02087-1 　

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    INTRODUCTION: Accumulating data on the associations between food consumption and lipid composition in the body is essential for understanding the effects of dietary habits on health. OBJECTIVES: As part of omics research in the Tohoku Medical Megabank Community-Based Cohort Study, this study sought to reveal the dietary impact on plasma lipid concentration in a Japanese population. METHODS: We conducted a correlation analysis of food consumption and plasma lipid concentrations measured using mass spectrometry, for 4032 participants in Miyagi Prefecture, Japan. RESULTS: Our analysis revealed 83 marked correlations between six food categories and the concentrations of plasma lipids in nine subclasses. Previously reported associations, including those between seafood consumption and omega-3 fatty acids, were validated, while those between dairy product consumption and odd-carbon-number fatty acids (odd-FAs) were validated for the first time in an Asian population. Further analysis suggested that dairy product consumption is associated with odd-FAs via sphingomyelin (SM), which suggests that SM is a carrier of odd-FAs. These results are important for understanding odd-FA metabolism with regards to dairy product consumption. CONCLUSION: This study provides insight into the dietary impact on plasma lipid concentration in a Japanese population.

  57. ToMMo地域住民コホート調査におけるPreserved ratio impaired spirometryの有病と出生体重の因果関係の検討

    岩崎 史, 中谷 久美, 山田 充啓, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 千葉 一平, 寳澤 篤, 杉浦 久敏

    日本呼吸器学会誌　13　(増刊)　255-255　2024/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

    eISSN： 2186-5884

  58. 一般成人集団における血中好酸球数分布と関連要因の探索 ToMMo地域住民コホート調査

    鈴木 眞奈美, 山田 充啓, 中谷 直樹, 小暮 真奈, 千葉 一平, 中谷 久美, 畑中 里衣子, 高瀬 雅仁, 岩崎 史, 寳澤 篤, 杉浦 久敏

    日本呼吸器学会誌　13　(増刊)　255-255　2024/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

    eISSN： 2186-5884

  59. The Association of Urinary Sodium-to-Potassium Ratio and Estimated Urinary Sodium Excretion with Atrial Fibrillation among Participants without Hypertension(タイトル和訳中)

    時岡 紗由理, 中谷 直樹, 畑中 里衣子, 中谷 久美, 千葉 一平, 小暮 真奈, 後岡 広太郎, 大類 真嗣, 宇留野 晃, 小林 朋子, 児玉 栄一, 濱中 洋平, 布施 昇男, 寳澤 篤

    日本循環器学会学術集会抄録集　88回　PJ005-4　2024/03

    Publisher: (一社)日本循環器学会

  60. Low Hemoglobin Level and Elevated Inflammatory Hematological Ratios Associated With Depression and Sleep Disturbance. International-journal

    Tetsuya Akaishi, Kumi Nakaya, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Sayuri Tokioka, Satoshi Nagaie, Soichi Ogishima, Atsushi Hozawa

    Cureus　16　(3)　e56621　2024/03

    DOI： 10.7759/cureus.56621 　

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    BACKGROUND: The relationship between blood cell profiles, including hemoglobin (Hb) levels and inflammatory hematological ratios, and mental health problems currently remains unclear. AIM: This study aimed to investigate the relationship between blood cell profiles and mental health issues, including depressive state and sleep disturbance, while adjusting for potential demographic confounders. METHODOLOGY: This retrospective, cross-sectional, observational study used a population-based medical database from the Tohoku Medical Megabank Project with more than 60,000 volunteers. Data on age, sex, daily tobacco use, body mass index, and self-reported scores on the Kessler Psychological Distress Scale (K6), Athens Insomnia Scale (AIS), and the Center for Epidemiologic Studies Depression Scale (CES-D) were collected. RESULTS: A total of 62,796 volunteers (23,663 males and 39,133 females), aged ≥20 years at the time of the blood test, agreed to participate in this study. Among the evaluated blood cell profiles, Hb, hematocrit, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were significantly correlated with the K6, AIS, and CES-D scores, with strong statistical significance (p<0.0001 for all) in bivariate correlation analyses. A significant adjusted odds ratio (aOR) of the Hb level for elevated CES-D scores (aOR=0.965 [95% CI: 0.949-0.981], p<0.0001) was confirmed after adjusting for demographic data and daily tobacco use using a logistic regression model. Sensitivity analyses revealed that these associations existed in both males and females but were more prominent in the former. In male participants, a low Hb level was significantly associated with an elevated AIS score. The evaluated inflammatory hematological ratios, including NLR, PLR, and monocyte-to-lymphocyte ratio (MLR), also showed significant aORs with the K6, AIS, and CES-D scores after adjusting for demographic background. CONCLUSION: Low Hb levels and elevated inflammatory hematological ratios (NLR, MLR, and PLR) were associated with depressive state and sleep disturbances in the general population.

  61. Mortality from major causes and lifestyles by proportions of public assistance recipients among 47 prefectures in Japan: Ecological panel data analysis from 1999 to 2016. International-journal

    Nobuo Nishi, Kaori Kitaoka, Phap Tran Ngoc Hoang, Yukiko Okami, Keiko Kondo, Mizuki Sata, Aya Kadota, Mieko Nakamura, Katsushi Yoshita, Tomonori Okamura, Toshiyuki Ojima, Katsuyuki Miura

    Preventive medicine reports　39　102635-102635　2024/03

    DOI： 10.1016/j.pmedr.2024.102635 　

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    OBJECTIVE: Comprehensive investigations of correlations between subnational socioeconomic factors and trends in mortality and lifestyle are important for addressing public health problems. METHODS: Forty-seven prefectures in Japan were divided into quartiles based on the proportion of public assistance recipients (PPAR). Age-standardized mortality from all causes, cancer, heart disease, and stroke in each prefecture were averaged for these quartiles in 2000, 2005, 2010, and 2015. Data from the National Health and Nutrition Survey were obtained for the following periods: 1999-2001, 2003-2005, 2007-2009, 2012, and 2016. Body mass index (BMI), intake of total energy, vegetable and salt, step count, and prevalence of current smoking and drinking for individuals aged 40-69 years age range were standardized for each prefecture and averaged by quartile. A two-way analysis of variance was used to assess differences in mortality and lifestyle across different years or periods, and quartiles. RESULTS: Mortality rates decreased, with the first (lowest) quartile showing the lowest rates, across all causes, cancer and heart diseases in both sexes. BMI exhibited an increase in men, whereas, BMI in women and other lifestyle factors in both sexes, excluding smoking and drinking in women, exhibited a decrease. BMI, vegetable and salt intake, total energy intake in men, and smoking in women varied across quartiles. Lower quartiles exhibited lower BMI and smoking prevalence but higher energy, vegetables, and salt intake. CONCLUSIONS: PPAR exhibited favorable trends and significant differences in mortality related to all causes, cancer and heart disease across both sexes, along with BMI among women.

  62. Relationship between traditional risk factors for hypertension and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study

    Masato Takase, Naoki Nakaya, Kozo Tanno, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Tomohiro Nakamura, Takumi Hirata, Taku Obara, Mami Ishikuro, Yuka Kotozaki, Akira Uruno, Tomoko Kobayashi, Eiichi N. Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Hideki Ohmomo, Nobuo Fuse, Junichi Sugawara, Atsushi Shimizu, Yoko Izumi, Shinichi Kuriyama, Atsushi Hozawa

    Hypertension Research　2024/02/29

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41440-024-01582-1 　

    ISSN： 0916-9636

    eISSN： 1348-4214

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    Abstract Risk factors for hypertension have been emphasized in the Japanese Society of Hypertension Guidelines for the Management of Hypertension. However, large-scale studies on the association of smoking, potassium excretion, and gamma-glutamyl transferase level with BP in the Japanese population are limited. We conducted a cross-sectional study to examine the association between hypertension risk factors and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study (23,446 men and 38,921 women aged ≥20 years). A model adjusted for age, body mass index, smoking status, drinking status, estimated daily salt intake, potassium excretion, (or urinary sodium-to-potassium ratio), gamma-glutamyl transferase, physical activity, education level, status of damage to homes during the Great East Japan Earthquake, and residential areas was used. The average age and systolic blood pressure were 62.5 (10.3) years for men and 59.6 (11.3) years for women, 128.9 (16.7) mmHg for men and 124.7 (17.5) mmHg for women, respectively. Body mass index estimated daily salt intake, urinary sodium-to-potassium ratio and gamma-glutamyl transferase levels were positively associated with systolic blood pressure. Compared with never-drinkers, current drinkers who consumed 23–45 g/day and ≥46.0 g/day had significantly increased systolic blood pressure. Conversely, current smokers (1-10 cigarettes/day and 11-20 cigarettes/day) were inversely associated with systolic blood pressure compared to never-smokers. Overall, systolic blood pressure was associated with gamma-glutamyl transferase and hypertension risk factors, including body mass index, alcohol consumption, estimated daily salt intake, urinary sodium-to-potassium ratio, and potassium excretion. Our findings support the notion that lifestyle modifications should be attempted to prevent hypertension.

  63. Progress report of the Tohoku Medical Megabank Community-Based Cohort Study: Study profile of the repeated center-based survey during second period in Miyagi Prefecture.

    Atsushi Hozawa, Kumi Nakaya, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Junichi Sugawara, Eiichi Kodama, Yohei Hamanaka, Tomoko Kobayashi, Akira Uruno, Naho Tsuchiya, Takumi Hirata, Akira Narita, Akito Tsuboi, Toru Tamahara, Akihito Otsuki, Maki Goto, Makiko Taira, Ritsuko Shimizu, Kichiya Suzuki, Taku Obara, Masahiro Kikuya, Hirohito Metoki, Mami Ishikuro, Inaho Danjoh, Soichi Ogishima, Satoshi Nagaie, Naoko Minegishi, Masahiro Hiratsuka, Kazuki Kumada, Ichiko Nishijima, Takahiro Nobukuni, Yumi Yamaguchi-Kabata, Fuji Nagami, Shigeo Kure, Nobuo Fuse, Kengo Kinoshita, Yoko Izumi, Shinichi Kuriyama, Masayuki Yamamoto

    Journal of epidemiology　2024/02/24

    DOI： 10.2188/jea.JE20230241 　

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    BACKGROUND: The purpose of this study was to report the basic profile of the Miyagi Prefecture part of a repeated center-based survey during the second period (2nd period survey) of the Tohoku Medical Megabank Community-Based Cohort Study (TMM CommCohort Study), as well as the participants' characteristics based on their participation type in the baseline survey. METHODS: The 2nd period survey, conducted from June 2017 to March 2021, included participants of the TMM CommCohort Study (May 2013 to March 2016). In addition to the questionnaire, blood, urine, and physiological function tests were performed during the 2nd period survey. There were three main ways of participation in the baseline survey: Type 1, Type 1 additional, or Type 2 survey. The 2nd period survey was conducted in the same manner as the Type 2 survey, which was based on the community support center (CSC). RESULTS: In Miyagi Prefecture, 29,383 (57.7%) of 50,967 participants participated in the 2nd period survey. The participation rate among individuals who had visited the CSC was approximately 80%. Although some factors differed depending on the participation type in the baseline survey, the 2nd period survey respondents in the Type 1 and Type 2 survey groups at baseline had similar traits. CONCLUSIONS: The 2nd period survey of the TMM CommCohort Study provided detailed follow-up information. Following up on the health conditions of the participants will clarify the long-term effects of disasters and contribute to personalized prevention.

  64. Relationships of Fat Mass Index and Fat-Free Mass Index with Low-Density Lipoprotein Cholesterol Levels in the Tohoku Medical Megabank Community-Based Cohort Study.

    Masato Takase, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Taku Obara, Mami Ishikuro, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Yoko Izumi, Shinichi Kuriyama, Atsushi Hozawa

    Journal of atherosclerosis and thrombosis　2024/02/06

    DOI： 10.5551/jat.64535 　

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    AIMS: Although fat mass (FM) and fat-free mass (FFM) have an impact on lipid metabolism, the relationship between different body composition phenotypes and lipid profiles is still unclear. By dividing the FM and FFM by the square of the height, respectively, the f at mass index (FMI) and fat-free mass index (FFMI) can be used to determine the variations in body composition. This study aimed to investigate the relationship of combined FMI and FFMI with low-density lipoprotein cholesterol (LDL-C) levels. METHODS: This cross-sectional study comprised 5,116 men and 13,630 women without cardiovascular disease and without treatment for hypertension, and diabetes. Following sex-specific quartile classification, FMI and FFMI were combined into 16 groups. Elevated LDL-C levels were defined as LDL-C ≥ 140 mg/dL and/or dyslipidemia treatment. Multivariable logistic regression models were used to examine the relationships between combined FMI and FFMI and elevated LDL-C levels. RESULTS: Overall, elevated LDL-C levels were found in 1,538 (30.1%) men and 5,434 (39.9%) women. In all FFMI subgroups, a higher FMI was associated with elevated LDL-C levels. Conversely, FFMI was inversely associated with elevated LDL-C levels in most FMI subgroups. Furthermore, the groups with the highest FMI and lowest FFMI had higher odds ratios for elevated LDL-C levels than those with the lowest FMI and highest FFMI. CONCLUSIONS: Regardless of FFMI, FMI was positively associated with elevated LDL-C levels. Conversely, in the majority of FMI subgroups, FFMI was inversely associated with elevated LDL-C levels.

  65. Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people. International-journal Peer-reviewed

    Koyanagi Y.N, Nakatochi M, Namba S, Oze I, Charvat H, Narita A, Kawaguchi T, Ikezaki H, Hishida A, Hara M, Takezaki T, Koyama T, Nakamura Y, Suzuki S, Katsuura-Kamano S, Kuriki K, Nakamura Y, Takeuchi K, Hozawa A, Kinoshita K, Sutoh Y, Tanno K, Shimizu A, Ito H, Kasugai Y, Kawakatsu Y, Taniyama Y, Tajika M, Shimizu Y, Suzuki E, Hosono Y, Imoto I, Tabara Y, Takahashi M, Setoh K, Matsuda K, Nakano S, Goto A, Katagiri R, Yamaji T, Sawada N, Tsugane S, Wakai K, Yamamoto M, Sasaki M, Matsuda F, Okada Y, Iwasaki M, Brennan P, Matsuo K, The BioBank Japan, Proj

    Science advances　10　(4)　eade2780　2024/01/26

    DOI： 10.1126/sciadv.ade2780 　

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    An East Asian-specific variant on aldehyde dehydrogenase 2 (ALDH2 rs671, G>A) is the major genetic determinant of alcohol consumption. We performed an rs671 genotype-stratified genome-wide association study meta-analysis of alcohol consumption in 175,672 Japanese individuals to explore gene-gene interactions with rs671 behind drinking behavior. The analysis identified three genome-wide significant loci (GCKR, KLB, and ADH1B) in wild-type homozygotes and six (GCKR, ADH1B, ALDH1B1, ALDH1A1, ALDH2, and GOT2) in heterozygotes, with five showing genome-wide significant interaction with rs671. Genetic correlation analyses revealed ancestry-specific genetic architecture in heterozygotes. Of the discovered loci, four (GCKR, ADH1B, ALDH1A1, and ALDH2) were suggested to interact with rs671 in the risk of esophageal cancer, a representative alcohol-related disease. Our results identify the genotype-specific genetic architecture of alcohol consumption and reveal its potential impact on alcohol-related disease risk.

  66. Association of parity with the prevalence of hypertension in Japan: The Tohoku Medical Megabank Community‐based cohort study

    Hongxin Wang, Noriyuki Iwama, Keiichi Yuwaki, You Nakamichi, Hirotaka Hamada, Hasumi Tomita, Kazuma Tagami, Rie Kudo, Natsumi Kumagai, Hirohito Metoki, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Yaegashi, Masatoshi Saito

    The Journal of Clinical Hypertension　2024/01/08

    DOI： 10.1111/jch.14756 　

  67. Association between the Number of Deliveries and Cognitive Impairment Considering the Presence of Subclinical Cerebrovascular Diseases: the Ohasama Study

    Teiichiro Yamazaki, Kyoko Nomura, Michihiro Satoh, Azusa Hara, Megumi Tsubota-Utsugi, Takahisa Murakami, Kei Asayama, Yukako Tatsumi, Yuki Kobayashi, Takuo Hirose, Ryusuke Inoue, Tomoko Totsune, Masahiro Kikuya, Hirohito Metoki, Atsushi Hozawa, Yutaka Imai, Takayoshi Ohkubo

    The Tohoku Journal of Experimental Medicine　2024

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.2024.j139 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  68. 全国の一般地域住民における最近の循環器疾患発症率 NIPPON DATA2010

    門田 文, 大久保 孝義, 原田 亜紀子, 高嶋 直敬, 有馬 久富, 二宮 利治, 秦 淳, 寳澤 篤, 中村 幸志, 東山 綾, 大澤 正樹, 久松 隆史, 鳥居 さゆ希, 岡見 雪子, 近藤 慶子, 宮本 恵宏, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之

    Journal of Epidemiology　34　(Suppl.)　122-122　2024/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  69. 尿中Na、K、Na/K比と胃がん罹患との関連 東北メディカル・メガバンク計画地域住民コホート調査

    小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 小原 拓, 永家 聖, 布施 昇男, 泉 陽子, 栗山 進一, 中谷 直樹, 寳澤 篤

    Journal of Epidemiology　34　(Suppl.)　100-100　2024/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  70. 尿中ナトリウム/カリウム比と心房細動の関連の検討

    時岡 紗由理, 中谷 直樹, 畑中 里衣子, 千葉 一平, 中谷 久美, 小暮 真奈, 大類 正嗣, 宇留野 晃, 小林 朋子, 児玉 栄一, 濱中 洋平, 布施 昇男, 寳澤 篤

    Journal of Epidemiology　34　(Suppl.)　122-122　2024/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  71. 東北メディカル・メガバンク計画 地域住民コホート調査(宮城) これまでの進捗

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 石黒 真美, 大類 真嗣, 野田 あおい, 篠田 元気, 小原 拓, 宇留野 晃, 布施 昇男, 泉 陽子, 栗山 進一, 寳澤 篤

    Journal of Epidemiology　34　(Suppl.)　133-133　2024/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  72. ToMMo地域住民コホート調査におけるPreserved ratio impairment spirometryの有病と関連する要因の検討

    岩崎 史, 中谷 久美, 山田 充啓, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 千葉 一平, 菅野 郁美, 小原 拓, 石黒 真美, 大類 真嗣, 永家 聖, 中村 智洋, 荻島 創一, 布施 昇男, 泉 陽子, 栗山 進一, 杉浦 久敏, 寳澤 篤

    Journal of Epidemiology　34　(Suppl.)　139-139　2024/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  73. Alcohol Flushingと悪性腫瘍有病の関連 TMM計画地域住民コホート調査(宮城)

    土谷 祐馬, 中谷 久美, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 千葉 一平, 菅野 郁美, 小原 拓, 石黒 真美, 大類 正嗣, 永家 聖, 中村 智洋, 荻島 創一, 布施 昇男, 泉 陽子, 栗山 進一, 亀井 尚, 寳澤 篤

    Journal of Epidemiology　34　(Suppl.)　154-154　2024/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  74. 産後うつ・自殺問題の縦断的リスクと関連要因の検討 東北メディカル・メガバンク計画三世代コホート調査

    大類 真嗣, 小原 拓, 石黒 真美, 野田 あおい, 篠田 元気, 村上 慶子, 岩間 憲之, 千葉 一平, 中谷 久美, 畑中 里衣子, 小暮 真奈, 目時 弘仁, 菊谷 昌浩, 中谷 直樹, 寳澤 篤, 栗山 進一

    Journal of Epidemiology　34　(Suppl.)　158-158　2024/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  75. 震災による自宅損壊および心的外傷後ストレス反応と修正可能な認知症の危険因子の関連

    千葉 一平, 小暮 真奈, 中谷 久美, 畑中 里衣子, 小原 拓, 丹野 高三, 栗山 進一, 中谷 直樹, 寳澤 篤

    Journal of Epidemiology　34　(Suppl.)　174-174　2024/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  76. 遺伝要因、生活習慣の組み合わせと糖尿病発症の関連 東北メディカル・メガバンク地域住民コホート調査

    高瀬 雅仁, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 中村 智洋, 後岡 広太郎, 土屋 菜歩, 平田 匠, 松田 浩一, 栗山 進一, 木下 賢吾, 田宮 元, 寳澤 篤

    Journal of Epidemiology　34　(Suppl.)　176-176　2024/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  77. 全国の一般地域住民における最近の循環器疾患発症率 NIPPON DATA2010

    門田 文, 大久保 孝義, 原田 亜紀子, 高嶋 直敬, 有馬 久富, 二宮 利治, 秦 淳, 寳澤 篤, 中村 幸志, 東山 綾, 大澤 正樹, 久松 隆史, 鳥居 さゆ希, 岡見 雪子, 近藤 慶子, 宮本 恵宏, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之

    Journal of Epidemiology　34　(Suppl.)　122-122　2024/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  78. Study Profile of the Tsuruoka Metabolomics Cohort Study (TMCS) Peer-reviewed

    Sei Harada, Miho Iida, Naoko Miyagawa, Aya Hirata, Kazuyo Kuwabara, Minako Matsumoto, Tomonori Okamura, Shun Edagawa, Yoko Kawada, Atsuko Miyake, Ryota Toki, Miki Akiyama, Atsuki Kawai, Daisuke Sugiyama, Yasunori Sato, Ryo Takemura, Kota Fukai, Yoshiki Ishibashi, Suzuka Kato, Ayako Kurihara, Mizuki Sata, Takuma Shibuki, Ayano Takeuchi, Shun Kohsaka, Mitsuaki Sawano, Satoshi Shoji, Yoshikane Izawa, Masahiro Katsumata, Koichi Oki, Shinichi Takahashi, Tsubasa Takizawa, Hiroshi Maruya, Yuji Nishiwaki, Ryo Kawasaki, Akiyoshi Hirayama, Takamasa Ishikawa, Rintaro Saito, Asako Sato, Tomoyoshi Soga, Masahiro Sugimoto, Masaru Tomita, Shohei Komaki, Hideki Ohmomo, Kanako Ono, Yayoi Otsuka-Yamasaki, Atsushi Shimizu, Yoichi Sutoh, Atsushi Hozawa, Kengo Kinoshita, Seizo Koshiba, Kazuki Kumada

    Journal of Epidemiology　2024/01

    DOI： 10.2188/jea.je20230192 　

    ISSN： 0917-5040 1349-9092

  79. High blood pressure and colorectal cancer mortality in a 29-year follow-up of the Japanese general population: NIPPON DATA80

    Takashi Hisamatsu, Aya Kadota, Takehito Hayakawa, Yoshikuni Kita, Akiko Harada, Yukiko Okami, Keiko Kondo, Takayoshi Ohkubo, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima, Katsuyuki Miura, Shigeyuki Saitoh, Kiyomi Sakata, Atsushi Hozawa, Yosikazu Nakamura, Nobuo Nishi, Takayoshi Ohkubo, Yoshitaka Murakami, Toshiyuki Ojima, Koji Tamakoshi, Hideaki Nakagawa, Yoshikuni Kita, Aya Kadota, Yasuyuki Nakamura, Naomi Miyamatsu, Takehito Hayakawa, Nagako Okuda, Katsushi Yoshita, Yoshihiro Miyamoto, Makoto Watanabe, Akira Fujiyoshi, Kazunori Kodama, Fumiyoshi Kasagi, Yutaka Kiyohara

    Hypertension Research　47　(1)　206-214　2023/11/22

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41440-023-01497-3 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  80. Effects of greenery at different heights in neighbourhood streetscapes on leisure walking: a cross-sectional study using machine learning of streetscape images in Sendai City, Japan. International-journal Peer-reviewed

    Shusuke Sakamoto, Mana Kogure, Tomoya Hanibuchi, Naoki Nakaya, Atsushi Hozawa, Tomoki Nakaya

    International Journal of Health Geographics　22　(1)　29-29　2023/11/08

    DOI： 10.1186/s12942-023-00351-6 　

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    BACKGROUND: It has been pointed out that eye-level greenery streetscape promotes leisure walking which is known to be a health -positive physical activity. Most previous studies have focused on the total amount of greenery in the eye-level streetscape to investigate its association with walking behaviour. While it is acknowledged that taller trees contribute to greener environments, providing enhanced physical and psychological comfort compared to lawns and shrubs, the examination of streetscape metrics specifically focused on greenery height remains largely unexplored. Therefore, this study examined the relationship between objective indicators of street greenery categorized by height from a pedestrian viewpoint and leisure walking time. METHODS: We created streetscape indices of street greenery using Google Street View Images at 50-m intervals in an urban area in Sendai City, Japan. The indices were classified into four ranges according to the latitude of the virtual hemisphere centred on the viewer. We then investigated their relationship to self-reported leisure walking. RESULTS: Positive associations were identified between the street greenery in higher positions and leisure walking time, while there was no significant association between the greenery in lower positions. CONCLUSION: The findings indicated that streets with rich greenery in high positions may promote residents' leisure walking, indicating that greenery in higher positions contributes to thermally comfortable and aesthetic streetscapes, thus promoting leisure walking. Increasing the amount of greenery in higher positions may encourage residents to increase the time spent leisure walking.

  81. The association between depressive symptoms and masked hypertension in participants with normotension measured at research center. International-journal

    Sayuri Tokioka, Naoki Nakaya, Kumi Nakaya, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Hirohito Metoki, Takahisa Murakami, Michihiro Satoh, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension　2023/10/31

    DOI： 10.1038/s41440-023-01484-8 　

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    Masked hypertension is a risk factor for cardiovascular diseases. However, masked hypertension is sometimes overlooked owing to the requirement for home blood pressure measurements for diagnosing. Mental status influences blood pressure. To reduce undiagnosed masked hypertension, this study assessed the association between depressive symptoms and masked hypertension. This cross-sectional study used data from the Tohoku Medical Megabank Project Community-Based Cohort Study (conducted in Miyagi Prefecture, Japan, from 2013) and included participants with normotension measured at the research center (systolic blood pressure<140 mmHg and diastolic blood pressure <90 mmHg). Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (Japanese version). Masked hypertension was defined as normotension measured at the research center and home hypertension (home systolic blood pressure ≥135 mmHg or home diastolic blood pressure ≥85 mmHg). The study comprised 6705 participants (mean age: 55.7 ± 13.7 years). Of these participants, 1106 (22.1%) without depressive symptoms and 393 (23.2%) with depressive symptoms were categorized to have masked hypertension. Sex-specific and age-adjusted least mean squares for home blood pressure, not for research blood pressure were significantly higher in the group with depressive symptoms in both sex categories. The multivariate odds ratio for masked hypertension in the patients with depressive symptoms was 1.72 (95% confidence interval: 1.26-2.34) in male participants and 1.30 (95% confidence interval: 1.06-1.59) in female ones. Depressive symptoms were associated with masked hypertension in individuals with normotension measured at the research center. Depressive symptoms may be one of the risk factors for masked hypertension. Depressive symptoms were associated with masked hypertension in individuals with normotension measured at research center.

  82. Association between an Antioxidant-Rich Japanese Diet and Chronic Kidney Disease: The Ohasama Study.

    Megumi Tsubota-Utsugi, Michihiro Satoh, Jun Watanabe, Jun Takebayashi, Tomoyuki Oki, Yukako Tatsumi, Kei Asayama, Masahiro Kikuya, Takahisa Murakami, Takuo Hirose, Hirohito Metoki, Azusa Hara, Kyoko Nomura, Atsushi Hozawa, Yoshitaka Tsubono, Yutaka Imai, Takayoshi Ohkubo

    Journal of atherosclerosis and thrombosis　2023/10/17

    DOI： 10.5551/jat.64423 　

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    AIMS: Although physiological effects of hydrophilic- (H-) and lipophilic- (L-) antioxidant capacities (AOCs) are suggested to differ, the association of an antioxidant-rich diet and chronic kidney disease (CKD) incidence has not been examined. We therefore explored the association between the H- or L-AOC of a whole Japanese diet and CKD risk in a general population. METHODS: A total of 922 individuals without CKD (69.2% women; mean age, 59.5 years old) from Ohasama Town, Japan, were examined. CKD incidence was defined as the presence of proteinuria and/or an estimated glomerular filtration rate (eGFR) of ＜60 ml/min/1.73 m 2 . Consumption of H-/L-AOC was determined based on the oxygen radical absorbance capacity in a specially developed Japanese food AOC database. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated for new-onset CKD using a Cox proportional hazards model. RESULTS: During the median follow-up of 9.7 years, 137 CKD incidents were recorded. After adjusting for potential confounding variables, the highest quartile of L-AOC was significantly associated with a 51% reduced CKD risk among only women. An increased L-AOC intake was more effective in preventing eGFR reduction than in preventing proteinuria in women. These associations were not seen for H-AOC intake in both sexes and L-AOC intake in men. CONCLUSIONS: A high intake of lipophilic antioxidants may be associated with a reduced CKD risk. The balance between dietary antioxidant intake and pro-oxidants induced by unhealthy lifestyles may be crucial for preventing future kidney deterioration.

  83. The risk of withdrawal from hypertension treatment in coastal areas after the Great East Japan Earthquake: the TMM CommCohort Study

    Rieko Hatanaka, Naoki Nakaya, Mana Kogure, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Hideaki Hashimoto, Tomohiro Nakamura, Kotaro Nochioka, Taku Obara, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Akira Uruno, Eiichi N. Kodama, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

    Hypertension Research　2023/10/13

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41440-023-01454-0 　

    ISSN： 0916-9636

    eISSN： 1348-4214

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    Abstract This study aimed to examine whether risk of withdrawal from HTTx was higher in coastal areas that were severely damaged by tsunami than in inland areas. We conducted a cross-sectional study of 9218 participants aged ≥20 years in Miyagi, Japan. The odds ratios (ORs) and confidence interval (CI) for withdrawal from HTTx in coastal and inland groups were compared using multivariate logistic regression analysis, adjusting for potential confounders. In total, 194 of 5860 and 146 of 3358 participants in the inland and coastal groups, respectively, withdrew from HTTx treatment. OR (95%CI) of withdrawal from HTTx in the coastal group was 1.46 (1.14–1.86) compared to the inland group. According to housing damage, ORs (95% CI) in the no damage, partially destroyed, and more than half destroyed coastal groups compared with the no damage inland group were 1.62 (1.04–2.50), 1.69 (1.17–2.45), and 1.08 (0.71–1.65), respectively. In conclusion, the risk of HTTx withdrawal for participants whose homes in coastal areas were relatively less damaged was significantly higher compared with those in inland areas, while the risk of HTTx withdrawal for participants whose homes were more than half destroyed was not. Post-disaster administrative support for disaster victims is considered vital for continuation of their treatment.

  84. Association of Pro-Inflammatory Diet with Long-Term Risk of All-Cause and Cardiovascular Disease Mortality: NIPPON DATA80.

    Gantsetseg Ganbaatar, Yukiko Okami, Aya Kadota, Namuun Ganbaatar, Yuichiro Yano, Keiko Kondo, Akiko Harada, Nagako Okuda, Katsushi Yoshita, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima, Katsuyuki Miura

    Journal of atherosclerosis and thrombosis　2023/10/06

    DOI： 10.5551/jat.64330 　

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    AIM: A pro-inflammatory diet may increase the risk of cardiovascular disease (CVD) and all-cause mortality. However, this remains inconclusive as there is yet no study using a dietary record method that has been conducted in a large general population. Furthermore, an underestimation of the pro-inflammatory diet may exist due to the unmeasured effect of salt intake. Thus, in this study, we aimed to examine how pro-inflammatory diet is associated with the long-term risk of all-cause and CVD mortality in a representative Japanese population. METHODS: A national nutrition survey was conducted throughout Japan in 1980. After considering the exclusion criteria, 9284 individuals (56% women aged 30-92 years) were included in this study. In total, 20 dietary parameters derived from 3-day weighed dietary records were used to calculate the dietary inflammatory index (DII). The causes of death were monitored until 2009. The Cox proportional hazards model was used to determine multivariable-adjusted hazard ratios (HRs). Stratified analysis according to salt intake level was also performed. RESULTS: Compared with the lowest quartile of DII, multivariable-adjusted HRs (95% confidence intervals) in the highest quartile were 1.28 (1.15, 1.41), 1.35 (1.14, 1.60), 1.48 (1.15, 1.92), 1.62 (1.11, 2.38), and 1.34 (1.03, 1.75) for all-cause mortality, CVD mortality, atherosclerotic CVD mortality, coronary heart disease mortality, and stroke mortality, respectively. Stratified analysis revealed stronger associations among individuals with higher salt intake. CONCLUSIONS: As per our findings, a pro-inflammatory diet was determined to be positively associated with the long-term risk of all-cause and CVD mortality in a representative Japanese population. Thus, considering both salt intake and pro-inflammatory diet is deemed crucial for a comprehensive assessment of CVD risk.

  85. Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based Cohort Study.

    Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Akira Narita, Taku Obara, Mami Ishikuro, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

    Journal of atherosclerosis and thrombosis　2023/10/06

    DOI： 10.5551/jat.64425 　

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    AIM: The influence of family history of diabetes, probably reflecting genetic and lifestyle factors, on the association of combined genetic and lifestyle risks with diabetes is unknown. We examined these associations. METHODS: This cross-sectional study included 9,681 participants in the Tohoku Medical Megabank Community-based Cohort Study. A lifestyle score, which was categorized into ideal, intermediate, and poor lifestyles, was given. Family history was obtained through a self-reported questionnaire. A polygenic risk score (PRS) was constructed in the target data (n=1,936) using publicly available genome-wide association study summary statistics from BioBank Japan. For test data (n=7,745), we evaluated PRS performance and examined the associations of combined family history and genetic and lifestyle risks with diabetes. Diabetes was defined as non-fasting blood glucose ≥ 200 mmHg, HbA1c ≥ 6.5%, and/or self-reported diabetes treatment. RESULTS: In test data, 467 (6.0%) participants had diabetes. Compared with a low genetic risk and an ideal lifestyle without a family history, the odds ratio (OR) was 3.73 (95% confidence interval [CI], 1.92-7.00) for a lower genetic risk and a poor lifestyle without a family history. Family history was significantly associated with diabetes (OR, 3.58 [95% CI, 1.73-6.98]), even in those with a low genetic risk and an ideal lifestyle. Even among participants who had an ideal lifestyle without a family history, a high genetic risk was associated with diabetes (OR, 2.49 [95% CI, 1.65-3.85]). Adding PRS to family history and conventional lifestyle risk factors improved the prediction ability for diabetes. CONCLUSIONS: Our findings support the notion that a healthy lifestyle is important to prevent diabetes regardless of genetic risk.

  86. 地域住民コホート調査によるメタボロームと認知機能低下の関連

    木内 桜, 中谷 久美, 竹内 研時, 小坂 健, 寳澤 篤

    日本公衆衛生学会総会抄録集　82回　389-389　2023/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  87. 脂肪量指数と除脂肪量指数の組み合わせと高LDLコレステロール血症の関連

    高瀬 雅仁, 中村 智洋, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 後岡 広太郎, 土屋 菜歩, 平田 匠, 栗山 進一, 寳澤 篤

    日本公衆衛生学会総会抄録集　82回　272-272　2023/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  88. 東日本大震災による家屋損壊の程度と要支援・要介護認定・死亡リスクとの関連

    滑川 千慧, 小暮 真奈, 菅野 郁美, 畑中 里衣子, 中谷 久美, 千葉 一平, 平田 匠, 宇留野 晃, 布施 昇男, 中谷 直樹, 栗山 進一, 寳澤 篤

    日本公衆衛生学会総会抄録集　82回　286-286　2023/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  89. 東北メディカル・メガバンク計画三世代コホート調査 これまでの進捗

    大類 真嗣, 小原 拓, 石黒 真美, 野田 あおい, 篠田 元気, 村上 慶子, 菅野 郁美, 千葉 一平, 中谷 久美, 畑中 里衣子, 小暮 真奈, 中谷 直樹, 寶澤 篤, 栗山 進一

    日本公衆衛生学会総会抄録集　82回　370-370　2023/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  90. 東北メディカル・メガバンク計画三世代コホート調査における追加リクルート

    石黒 真美, 小原 拓, 野田 あおい, 篠田 元気, 大類 真嗣, 村上 慶子, 菅野 郁美, 千葉 一平, 中谷 久美, 畑中 里衣子, 小暮 真奈, 中谷 直樹, 寳澤 篤, 栗山 進一

    日本公衆衛生学会総会抄録集　82回　370-370　2023/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  91. コホート調査データの連係・活用推進のための基盤整備 マイToMMoの開発と実装

    野田 あおい, 篠田 元気, 石黒 真美, 千葉 一平, 大類 真嗣, 村上 慶子, 小原 拓, 菅野 郁美, 中谷 久美, 畑中 里衣子, 小暮 真奈, 中谷 直樹, 寳澤 篤, 栗山 進一

    日本公衆衛生学会総会抄録集　82回　371-371　2023/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  92. 東北メディカル・メガバンク計画地域住民コホート調査(宮城) これまでの進捗

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 石黒 真美, 大類 真嗣, 野田 あおい, 篠田 元気, 村上 慶子, 小原 拓, 栗山 進一, 寳澤 篤

    日本公衆衛生学会総会抄録集　82回　398-398　2023/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  93. 東北メディカル・メガバンク計画地域住民コホート調査詳細三次調査(岩手)の進捗

    事崎 由佳, 武部 典子, 山崎 弥生, 赤井 純子, 照井 春樹, 岩渕 光子, 大塚 耕太郎, 中谷 直樹, 寳澤 篤, 丹野 高三

    日本公衆衛生学会総会抄録集　82回　369-369　2023/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  94. 出産回数と認知機能との関連におけるアテローム性動脈硬化の影響 大迫研究

    山崎 貞一郎, 野村 恭子, 佐藤 倫広, 原 梓, 坪田 恵[宇津木], 村上 任尚, 浅山 敬, 辰巳 友佳子, 廣瀬 卓男, 菊谷 昌浩, 目時 弘仁, 寳澤 篤, 大久保 孝義

    日本公衆衛生学会総会抄録集　82回　434-434　2023/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  95. 東北メディカル・メガバンク計画地域住民コホート調査詳細三次調査(岩手)の進捗

    事崎 由佳, 武部 典子, 山崎 弥生, 赤井 純子, 照井 春樹, 岩渕 光子, 大塚 耕太郎, 中谷 直樹, 寳澤 篤, 丹野 高三

    日本公衆衛生学会総会抄録集　82回　369-369　2023/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  96. Trends in mortality from major causes and lifestyle factors by per capita prefectural income: Ecological panel data analysis from 1995 to 2016 in Japan. International-journal

    Nobuo Nishi, Kaori Kitaoka, Phap Tran Ngoc Hoang, Yukiko Okami, Keiko Kondo, Mizuki Sata, Aya Kadota, Mieko Nakamura, Katsushi Yoshita, Tomonori Okamura, Toshiyuki Ojima, Katsuyuki Miura

    Preventive medicine reports　35　102348-102348　2023/10

    DOI： 10.1016/j.pmedr.2023.102348 　

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    In Japan, trends in mortality and lifestyle have not been fully investigated according to subnational socioeconomic factors. Forty-seven prefectures (subnational units) were divided into quartiles by annual per capita prefectural income. Age-standardized mortality from all causes, cancer, heart disease, and stroke was averaged by quartile in 1995, 2000, 2005, 2010, and 2015. Data from the National Health and Nutrition Survey were obtained for periods 1 (1995-1997), 2 (1999-2001), 3 (2003-2005), 4 (2007-2009), 5 (2012), and 6 (2016). Body mass index (BMI), the intake of vegetables and salt, the number of steps, and the prevalence of current smoking and drinking for the 40-69-year age range were standardized by 10-year age groups in the 2010 Japanese population and were averaged by quartile. Differences in mortality and lifestyle by year and period, and quartile were tested using a two-way analysis of variance. Mortality decreased in both sexes and mortality in men from all causes, cancer, and stroke differed by quartile, with mortality highest in the first (lowest) quartile. BMI in men and smoking prevalence in women increased, whereas remaining lifestyle factors except for the prevalence of drinking decreased in women. BMI and the number of steps in both sexes and current smoking prevalence in women differed by quartile, with lower quartiles showing a higher BMI and fewer step counts. In conclusion, favorable trends and significant differences in mortality from all causes, cancer, and stroke in men and BMI in women were observed by per capita prefectural income level.

  97. Association Between Olfactory Test Data with Multiple Levels of Odor Intensity and Suspected Cognitive Impairment: A Cross-Sectional Study. International-journal

    Shuichi Sato, Takao Imaeda, Shunji Mugikura, Naoko Mori, Masaki Takanashi, Kazumi Hayakawa, Tomo Saito, Makiko Taira, Akira Narita, Mana Kogure, Ippei Chiba, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Ryosuke Ishiwata, Tomohiro Nakamura, Ikuko N Motoike, Naoki Nakaya, Seizo Koshiba, Kengo Kinoshita, Shinichi Kuriyama, Soichi Ogishima, Fuji Nagami, Nobuo Fuse, Atsushi Hozawa

    Journal of Alzheimer's disease : JAD　2023/09/11

    DOI： 10.3233/JAD-230318 　

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    BACKGROUND: Olfactory function decline has recently been reported to be associated with a risk of cognitive impairment. Few population-based studies have included younger adults when examining the association between olfactory test data with multiple odor intensities and suspected cognitive impairment. OBJECTIVE: We investigated the association between high-resolution olfactory test data with fewer odors and suspected cognitive impairments. We also examined the differences between older and younger adults in this association. METHODS: The Japanese version of the Montreal Cognitive Assessment (MoCA-J) was administered to 1,450 participants, with three odor-intensity-level olfactometry using six different odors. Logistic regressions to discriminate suspected cognitive impairment were conducted to examine the association, adjusted for age, sex, education duration, and smoking history. Data were collected from the Program by Tohoku University Tohoku Medical Megabank Organization, with an additional olfactory test conducted between 2019 and 2021. RESULTS: We generally observed that the lower the limit of distinguishable odor intensity was, the higher the MoCA-J score was. The combination of spearmint and stuffy socks contributed most to the distinction between suspected and unsuspected cognitive impairment. Furthermore, the association was significant in women aged 60-74 years (adjusted odds ratio 0.881, 95% confidence interval [0.790, 0.983], p = 0.024). CONCLUSIONS: The results indicate an association between the limit of distinguishable odor intensity and cognitive function. The olfactory test with multiple odor intensity levels using fewer odors may be applicable for the early detection of mild cognitive impairment, especially in older women aged 60-74 years.

  98. 分娩回数と高血圧との関連 東北メディカル・メガバンク機構地域住民コホート調査

    内堀 洪欣, 岩間 憲之, 湯脇 恵一, 中道 洋, 濱田 裕貴, 富田 芙弥, 田上 和磨, 工藤 理永, 熊谷 奈津美, 目時 弘仁, 中谷 直樹, 寳澤 篤, 栗山 進一, 八重樫 伸生, 齋藤 昌利

    日本妊娠高血圧学会雑誌　29　G-06　2023/09

    Publisher: (一社)日本妊娠高血圧学会

    ISSN： 1880-3172

  99. 高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連 東北メディカル・メガバンク地域住民コホート調査

    高瀬 雅仁, 平田 匠, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 目時 弘仁, 佐藤 倫広, 小原 拓, 栗山 進一, 田宮 元, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　45回　261-261　2023/09

    Publisher: (NPO)日本高血圧学会

  100. 高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連 東北メディカル・メガバンク地域住民コホート調査

    高瀬 雅仁, 平田 匠, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 目時 弘仁, 佐藤 倫広, 小原 拓, 栗山 進一, 田宮 元, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　45回　358-358　2023/09

    Publisher: (NPO)日本高血圧学会

  101. 予後に基づく家庭血圧に基づく血圧日間変動の基準値 大迫研究

    佐藤 倫広, 目時 弘仁, 村上 任尚, 辰巳 友佳子, 廣瀬 卓男, 原 梓, 野村 恭子, 浅山 敬, 菊谷 昌浩, 寳澤 篤, 今井 潤, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集　45回　359-359　2023/09

    Publisher: (NPO)日本高血圧学会

  102. 高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連 東北メディカル・メガバンク地域住民コホート調査

    高瀬 雅仁, 平田 匠, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 目時 弘仁, 佐藤 倫広, 小原 拓, 栗山 進一, 田宮 元, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　45回　261-261　2023/09

    Publisher: (NPO)日本高血圧学会

  103. 高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連 東北メディカル・メガバンク地域住民コホート調査

    高瀬 雅仁, 平田 匠, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 目時 弘仁, 佐藤 倫広, 小原 拓, 栗山 進一, 田宮 元, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　45回　358-358　2023/09

    Publisher: (NPO)日本高血圧学会

  104. Associations between birth weight and lung function in a Japanese adult population: The tohoku medical megabank community-based cohort study. International-journal

    Takashi Ohe, Mitsuhiro Yamada, Atsushi Hozawa, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Nobuo Fuse, Shinichi Kuriyama, Ayumi Mitsune, Ayumi Suzuki, Shuichiro Matsumoto, Tetsuya Hatakeyama, Chikashi Iwasaki, Manami Suzuki, Naoya Fujino, Tadahisa Numakura, Tomohiro Ichikawa, Akira Koarai, Tsutomu Tamada, Masayuki Yamamoto, Masakazu Ichinose, Hisatoshi Sugiura

    Respiratory investigation　61　(5)　588-600　2023/07/08

    DOI： 10.1016/j.resinv.2023.06.004 　

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    BACKGROUND: Birth weight, as a measure of intrauterine growth, is commonly used in epidemiological studies and is reported to be associated with adult lung function. However, findings regarding this association in previous studies have been inconsistent. Furthermore, no studies have reported associations stratified by age or smoking status, or adjusted for eosinophil count or other parameters related to type 2 airway inflammation. METHODS: This cross-sectional study included 2632 men and 7237 women aged ≥20 years living in Miyagi Prefecture, Japan. Lung function was assessed based on spirometry. Birth weight data were obtained through a questionnaire survey. Analysis of covariance was used to evaluate the associations between birth weight and lung function, adjusting for potential confounders. Stratified analyses by age and smoking status were also conducted, together with a sub-analysis for low birth-weight participants. RESULTS: Birth weight was positively associated with forced expiratory volume in 1 s (FEV1) for both sexes and with vital capacity in women, after adjusting for height, age, smoking status, and parameters related to type 2 airway inflammation. The stratified analysis for smoking status revealed associations in never-smokers and ex-smokers. When stratified by age, the associations were confirmed in middle-aged participants. The effect of smoking status on the FEV1 of low birth-weight participants was not significant. CONCLUSIONS: Our analysis of a large, Japanese adult population showed that birth weight was independently and positively associated with adult lung function, even after adjustment for age, height, smoking status, and parameters related to type 2 airway inflammation.

  105. Associations of Dental Health With the Progression of Hippocampal Atrophy in Community-Dwelling Individuals: The Ohasama Study. International-journal

    Satoshi Yamaguchi, Takahisa Murakami, Michihiro Satoh, Takamasa Komiyama, Takashi Ohi, Yoshitada Miyoshi, Kosei Endo, Takako Hiratsuka, Azusa Hara, Yukako Tatsumi, Tomoko Totsune, Kei Asayama, Masahiro Kikuya, Kyoko Nomura, Atsushi Hozawa, Hirohito Metoki, Yutaka Imai, Makoto Watanabe, Takayoshi Ohkubo, Yoshinori Hattori

    Neurology　101　(10)　10.1212/WNL.0000000000207579-10.1212/WNL.0000000000207579　2023/07/05

    Publisher: Ovid Technologies (Wolters Kluwer Health)

    DOI： 10.1212/wnl.0000000000207579 　

    ISSN： 0028-3878

    eISSN： 1526-632X

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    Background and Objectives Although tooth loss and periodontitis have been considered risk factors for Alzheimer's disease, recent longitudinal researches have not found a significant association with hippocampal atrophy. Therefore, this study aimed to clarify a longitudinal association between the number of teeth present (NTP) and hippocampal atrophy dependent on the severity of periodontitis in a late middle-aged and older adult population. Methods This study included community-dwelling individuals aged ≥55 years who had no cognitive decline and had undergone brain magnetic resonance imaging (MRI) and oral and systemic data collection twice at 4-year intervals. Hippocampal volumes were obtained from MRIs by automated region-of-interest analysis. The mean periodontal probing depth (mean PD) was used as a measure of periodontitis. Multiple regression analysis was performed with the annual symmetric percentage change (SPC) of the hippocampal volume as the dependent variable and including an interaction term between NTP and mean PD as the independent variable. The interaction details were examined using the Johnson–Neyman technique and simple slope analysis. The three-way interaction of NTP, mean PD, and time on hippocampal volume was analyzed using a linear mixed-effects model, and the interaction of NTP and time was examined in subgroups divided by the median mean PD. In all models, dropout bias was adjusted by inverse probability weighting. Results The data of 172 participants were analyzed. The qualitative interaction between NTP and mean PD was significant for the annual SPC in the left hippocampus. The regression coefficient of the NTP on annual SPC in the left hippocampus was significantly positive (B=0.038,P=.026) at the low-level mean PD (mean-1SD) and significantly negative (B=-0.054,P=.001) at the high-level mean PD (mean+1SD). Similar results were obtained in the linear mixed-effects model; the interaction of NTP and time was significant in the higher mean PD group. Discussion In a late middle-aged and older cohort, fewer teeth were associated with a faster rate of left hippocampal atrophy in patients with mild periodontitis, whereas having more teeth was associated with a faster rate of atrophy in those with severe periodontitis. The importance of keeping teeth healthy is suggested.

  106. Association of Central Blood Pressure and Carotid Intima Media Thickness with New-Onset Hypertension in People with High Normal Blood Pressure.

    Sayuri Tokioka, Naoki Nakaya, Kumi Nakaya, Masato Takase, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Hirohito Metoki, Takahisa Murakami, Michihiro Satoh, Tomohiro Nakamura, Taku Obara, Yohei Hamanaka, Tomoko Kobayashi, Akira Uruno, Junichi Sugawara, Eiichi N Kodama, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

    Journal of atherosclerosis and thrombosis　2023/07/05

    DOI： 10.5551/jat.64151 　

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    AIM: People with high normal blood pressure (BP) have a higher risk of cardiovascular events than those with normal BP; therefore, progression to hypertension (HT) should be prevented. We aimed to assess the HT risk using central BP and carotid intima media thickness (CIMT) in people with high normal BP. METHODS: This prospective cohort study used the Tohoku Medical Megabank Community-Based Project Cohort Study (conducted from 2013 in Miyagi Prefecture in Japan). The participants had a high normal BP, defined as a systolic BP of 120-139 mmHg and diastolic BP ＜90 mmHg using brachial BP measurement during the baseline survey. The outcome was new-onset HT during the secondary survey, conducted four years after the baseline survey. RESULTS: Overall, 4,021 participants with high normal BP during the baseline survey, with an average age of 58.7 years, were included; 1,030 (26%) were diagnosed with new-onset HT during the secondary survey, 3.5± 0.7 years after the baseline survey. The multivariable odds ratio (95% confidence interval) for HT in the highest versus lowest quartile of central BP was 1.7 (1.2-2.4, p=0.0030), and that of CIMT was 1.8 (1.4-2.4, p＜0.001). Subgroup analysis according to age (＜60 and ≥ 60 years) and sex revealed that the central BP was influential in groups with younger age and female individuals; CIMT was influential in all groups. CONCLUSIONS: Higher central BP and thicker CIMT at the baseline were correlated with new-onset HT in individuals with high normal BP, independent of brachial systolic BP and other cardiovascular risk factors.

  107. 産後女性のうつ・自殺関連問題の縦断的リスク評価の記述的分析 東北メディカル・メガバンク計画三世代コホート調査

    大類 真嗣, 小原 拓, 石黒 真美, 野田 あおい, 篠田 元気, 千葉 一平, 中谷 久美, 畑中 里衣子, 小暮 真奈, 中谷 直樹, 寳澤 篤, 栗山 進一

    東北公衆衛生学会誌　(72)　25-25　2023/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  108. 体組成と身体学的バイオマーカーの関連 東北メディカル・メガバンク計画地域住民コホート調査

    高瀬 雅仁, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 寳澤 篤

    東北公衆衛生学会誌　(72)　34-34　2023/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  109. 自宅から近隣施設までの距離と各種検査データとの関連 地理情報システム(GIS)を用いた検討

    畑中 里衣子, 小暮 真奈, 中谷 久美, 千葉 一平, 菅野 郁美, 中谷 直樹, 寳澤 篤

    東北公衆衛生学会誌　(72)　38-38　2023/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  110. Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background Peer-reviewed

    Makiko Taira, Shunji Mugikura, Naoko Mori, Atsushi Hozawa, Tomo Saito, Tomohiro Nakamura, Hideyasu Kiyomoto, Tadao Kobayashi, Soichi Ogishima, Fuji Nagami, Akira Uruno, Ritsuko Shimizu, Tomoko Kobayashi, Jun Yasuda, Shigeo Kure, Miyuki Sakurai, Ikuko N. Motoike, Kazuki Kumada, Naoki Nakaya, Taku Obara, Kentaro Oba, Atsushi Sekiguchi, Benjamin Thyreau, Tatsushi Mutoh, Yuji Takano, Mitsunari Abe, Norihide Maikusa, Yasuko Tatewaki, Yasuyuki Taki, Nobuo Yaegashi, Hiroaki Tomita, Kengo Kinoshita, Shinichi Kuriyama, Nobuo Fuse, Masayuki Yamamoto

    JMA Journal　6　(3)　246-264　2023/07

    Publisher: Japan Medical Association

    DOI： 10.31662/jmaj.2022-0220 　

    ISSN： 2433-328X

    eISSN： 2433-3298

  111. Association between Low Forced Vital Capacity and High Pneumonia Mortality, and Impact of Muscle Power. International-journal

    Nanako Shiokawa, Tatsuma Okazaki, Yoshimi Suzukamo, Midori Miyatake, Mana Kogure, Naoki Nakaya, Atsushi Hozawa, Satoru Ebihara, Shin-Ichi Izumi

    Journal of clinical medicine　12　(9)　2023/05/04

    DOI： 10.3390/jcm12093272 　

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    Impaired % predicted value forced vital capacity (% FVC) is related to higher all-cause mortality in aged adults, and strong muscle force may improve this relationship. A muscle disease, sarcopenia, causes higher mortality. We aimed to identify the unknown disease that relates impaired % FVC with higher mortality in aged adults among the three major leading causes of death, and the effect of strong leg force on this relationship. Cox proportional hazard model analyzed the longitudinal Tsurugaya cohort that registered 1048 aged Japanese for 11 years. The primary outcome was the relationship between % FVC and mortality by cancer, cardiovascular disease, or pneumonia. Exposure variables were % FVC or leg force divided by 80% or median values, respectively. The secondary outcome was the effects of leg force on the relationship. Among the diseases, % FVC < 80% was related only to higher pneumonia mortality (hazard ratio [HR], 4.09; 95% CI, 1.90-8.83) relative to the % FVC ≥ 80% group before adjustment. Adding the leg force as an explanatory variable reduced the HR to 3.34 (1.54-7.25). Weak leg force might indicate sarcopenia, and its prevention may improve higher pneumonia mortality risk related to impaired % FVC, which we may advise people in clinical settings.

  112. Relationship between age-related hearing loss and consumption of coffee and tea.

    Gosuke Watarai, Jun Suzuki, Ikuko N Motoike, Miyuki Sakurai, Ryoukichi Ikeda, Tetsuaki Kawase, Kengo Kinoshita, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Fuse, Masayuki Yamamoto, Yukio Katori

    Geriatrics & gerontology international　2023/05/03

    DOI： 10.1111/ggi.14589 　

  113. 特定健診会場で測定した尿Na/K比が与える血圧への影響 3年間のNDBオープンデータとの比較

    小暮 真奈, 及川 満代, 黒川 悦子, 永吉 翔, 志賀 利一, 牛田 悠介, 上田 宏幸, 本間 洋子, 中谷 直樹, 寳澤 篤

    日本循環器病予防学会誌　58　(2)　155-155　2023/05

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  114. 高齢者における尿Na/K比の血圧への影響は非高齢者より大きい

    平田 匠, 小暮 真奈, 中村 智洋, 小原 拓, 中谷 直樹, 栗山 進一, 丹野 高三, 寳澤 篤

    日本老年医学会雑誌　60　(Suppl.)　178-178　2023/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  115. 抑うつ症状と家庭高血圧発症リスクの関連 東北メディカル・メガバンク計画地域住民コホート調査

    時岡 紗由理, 中谷 直樹, 中谷 久美, 小暮 真奈, 千葉 一平, 畑中 里衣子, 菅野 郁美, 小原 拓, 栗山 進一, 寳澤 篤

    日本循環器病予防学会誌　58　(2)　146-146　2023/05

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  116. 食事における抗酸化力と慢性腎臓病発症との関連 大迫研究

    坪田 恵, 佐藤 倫広, 辰巳 友佳子, 浅山 敬, 菊谷 昌浩, 村上 任尚, 廣瀬 卓男, 目時 弘仁, 寳澤 篤, 大久保 孝義

    日本循環器病予防学会誌　58　(2)　158-158　2023/05

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  117. 慢性腎臓病発症に対する高血圧と糖尿病の複合効果

    遠山 真弥, 佐藤 倫広, 村上 任尚, 橋本 英明, 中山 晋吾, 小原 拓, 中谷 直樹, 森 建文, 大久保 孝義, 今井 潤, 寳澤 篤, 目時 弘仁

    日本腎臓学会誌　65　(3)　259-259　2023/05

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  118. Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation. International-journal

    Akiko Hanyuda, Atsushi Goto, Ryoko Katagiri, Yuriko N Koyanagi, Masahiro Nakatochi, Yoichi Sutoh, Shiori Nakano, Isao Oze, Hidemi Ito, Taiki Yamaji, Norie Sawada, Masao Iwagami, Aya Kadota, Teruhide Koyama, Sakurako Katsuura-Kamano, Hiroaki Ikezaki, Keitaro Tanaka, Toshiro Takezaki, Issei Imoto, Midori Suzuki, Yukihide Momozawa, Kenji Takeuchi, Akira Narita, Atsushi Hozawa, Kengo Kinoshita, Atsushi Shimizu, Kozo Tanno, Keitaro Matsuo, Shoichiro Tsugane, Kenji Wakai, Makoto Sasaki, Masayuki Yamamoto, Motoki Iwasaki

    Scientific reports　13　(1)　7052-7052　2023/04/29

    DOI： 10.1038/s41598-023-33966-7 　

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    Observational studies suggest that abnormal glucose metabolism and insulin resistance contribute to colorectal cancer; however, the causal association remains unknown, particularly in Asian populations. A two-sample Mendelian randomisation analysis was performed to determine the causal association between genetic variants associated with elevated fasting glucose, haemoglobin A1c (HbA1c), and fasting C-peptide and colorectal cancer risk. In the single nucleotide polymorphism (SNP)-exposure analysis, we meta-analysed study-level genome-wide associations of fasting glucose (~ 17,289 individuals), HbA1c (~ 52,802 individuals), and fasting C-peptide (1,666 individuals) levels from the Japanese Consortium of Genetic Epidemiology studies. The odds ratios of colorectal cancer were 1.01 (95% confidence interval [CI], 0.99-1.04, P = 0.34) for fasting glucose (per 1 mg/dL increment), 1.02 (95% CI, 0.60-1.73, P = 0.95) for HbA1c (per 1% increment), and 1.47 (95% CI, 0.97-2.24, P = 0.06) for fasting C-peptide (per 1 log increment). Sensitivity analyses, including Mendelian randomisation-Egger and weighted-median approaches, revealed no significant association between glycaemic characteristics and colorectal cancer (P > 0.20). In this study, genetically predicted glycaemic characteristics were not significantly related to colorectal cancer risk. The potential association between insulin resistance and colorectal cancer should be validated in further studies.

  119. 10年間のコホート調査に基づく東日本大震災被災者における心理的苦痛の経年変化 Peer-reviewed

    臼倉 瞳, 内海 裕介, 瀬戸 萌, 佐久間 篤, 菅原 由美, 國井 泰人, 中谷 直樹, 寳澤 篤, 辻 一郎, 富田 博秋

    精神神経学雑誌　125　(4)　266-274　2023/04/25

    DOI： 10.57369/pnj.23-039 　

  120. Characteristics of disorders of gut-brain interaction in the Japanese population in the Rome Foundation Global Epidemiological Study. International-journal

    Shin Fukudo, Kumi Nakaya, Tomohiko Muratsubaki, Naoki Nakaya, Atsushi Hozawa, Shrikant I Bangdiwala, Olafur S Palsson, Ami D Sperber, Motoyori Kanazawa

    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society　35　(6)　e14581　2023/04/24

    DOI： 10.1111/nmo.14581 　

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    BACKGROUND: The aims were to use Japanese data from the Rome Foundation Global Epidemiological Study (RFGES) to test the hypotheses that severity of gastrointestinal (GI) symptoms and psychosocial disturbance are ordered as Rome IV irritable bowel syndrome (IBS) > Rome III IBS > DGBI, not IBS > others. METHODS: Subjects were 2504 Japanese in the RFGES. We assessed DGBI/IBS diagnoses with Rome IV/III, IBS Symptom Severity Scale (IBS-SSS), Patient Health Questionnaire (PHQ) for anxiety/depression and non-GI somatic symptoms, PROMIS-10 for quality of life (QOL), Work Productivity and Activity Impairment (WPAI) Questionnaire, parts of Self-reported IBS Questionnaire (SIBSQ) for meal effect and stress effect, Food Frequency Questionnaire, and medication questions. KEY RESULTS: The prevalence of Rome IV DGBI was as follows; IBS-C 0.5%, IBS-D 0.8%, IBS-M 0.8%, IBS-U 0.1%, unspecified functional bowel disorder 10.7%, postprandial distress syndrome 2.2%, and epigastric pain syndrome 0.3%. Rome III IBS prevalence; IBS-C 3.0%, IBS-D 3.1%, IBS-M 2.7%, and IBS-U 0.6%. Comparison among Rome IV IBS (n = 54), Rome III IBS (n = 197), other DGBI (n = 746), others (n = 1389) revealed significant order as Rome IV IBS > Rome III IBS > other DGBI > others in IBS-SSS, anxiety/depression, activity impairment, non-GI symptoms, physical QOL, mental QOL, exacerbated symptoms by meals and perceived stress (all p < 0.001). CONCLUSIONS & INFERENCES: These findings support the study hypotheses. Data from Japan as a culturally homogenous country suggest Rome IV IBS is more severe and hence has more gut-brain psychobehavioral involvement than Rome III IBS.

  121. White blood cell count profiles in anti-aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorder and anti-myelin oligodendrocyte glycoprotein antibody-associated disease. International-journal

    Tetsuya Akaishi, Tatsuro Misu, Kazuo Fujihara, Kumi Nakaya, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Kimihiko Kaneko, Toshiyuki Takahashi, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima, Atsushi Hozawa

    Scientific reports　13　(1)　6481-6481　2023/04/20

    DOI： 10.1038/s41598-023-33827-3 　

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    White blood cell (WBC) count profiles in anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD) and anti-myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are still unknown. This study evaluated the total WBC count, differential WBC counts, monocyte-to-lymphocyte ratio (MLR), and neutrophil-to-lymphocyte ratio (NLR) in patients with these diseases within three months from an attack before acute treatment or relapse prevention and compared the profiles with those in matched volunteers or in multiple sclerosis (MS) patients. AQP4-NMOSD patients (n = 13) had a higher neutrophil count (p = 0.0247), monocyte count (p = 0.0359), MLR (p = 0.0004), and NLR (p = 0.0037) and lower eosinophil (p = 0.0111) and basophil (p = 0.0283) counts than those of AQP4-NMOSD-matched volunteers (n = 65). Moreover, patients with MOGAD (n = 26) had a higher overall WBC count (p = 0.0001), neutrophil count (p < 0.0001), monocyte count (p = 0.0191), MLR (p = 0.0320), and NLR (p = 0.0002) than those of MOGAD-matched volunteers (n = 130). The three demyelinating diseases showed similar levels of the total and differential WBC counts; however, MOGAD and MS showed different structures in the hierarchical clustering and distributions on a two-dimensional canonical plot using differential WBC counts from the other three groups. WBC count profiles were similar in patients with MOGAD and MS but differed from profiles in matched volunteers or patients with AQP4-NMOSD.

  122. Combined fat mass and fat-free mass indices and lung function among Japanese population: The Tohoku Medical Megabank Community-based Cohort Study.

    Masato Takase, Mitsuhiro Yamada, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

    Journal of epidemiology　2023/04/08

    DOI： 10.2188/jea.JE20220355 　

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    BACKGROUND: Although fat mass index (FMI) and fat-free mass index (FFMI) affect lung function, FMI and FFMI are not independent of each other since FMI and FFMI were calculated as fat mass and fat-free mass divided by height squared, respectively. We aimed to examine the association of combined FMI and FFMI with lung function. METHODS: In this cross-sectional study, lung function was evaluated using forced expiratory volume at 1 s and forced vital capacity was measured using spirometry. Both FMI and FFMI were classified into sex-specific quartiles (16 groups). Analysis of covariance was used to assess the associations of combined FMI and FFMI with lung function. The trend test was conducted by stratifying the FMI and FFMI, scoring the categories from 1-4 (lowest-highest), and entering the number as a continuous term in the regression model. RESULTS: This study included 3,736 men and 8,821 women aged ≥20 years living in Miyagi Prefecture, Japan. The mean FEV1 (standard deviation) was 3.0 (0.7) L for men and 2.3 (0.5) L for women. The mean FVC was 3.8 (0.7) L for men and 2.8 (0.5) L for women. The FMI was inversely associated with lung function among all FFMI subgroups in both sexes. Conversely, FFMI was positively associated with lung function in all FMI subgroups in both sexes. CONCLUSIONS: Higher FMI was associated with lower lung function independent of FFMI; higher FFMI was associated with higher lung function independent of FMI. Reducing FMI and maintaining FFMI might be important for respiratory health.

  123. The long-term reproducibility of the white-coat effect on blood pressure as a continuous variable from the Ohasama Study. International-journal

    Michihiro Satoh, Tomoya Yoshida, Hirohito Metoki, Takahisa Murakami, Yukako Tatsumi, Takuo Hirose, Kyosuke Takabatake, Megumi Tsubota-Utsugi, Azusa Hara, Kyoko Nomura, Kei Asayama, Masahiro Kikuya, Atsushi Hozawa, Yutaka Imai, Takayoshi Ohkubo

    Scientific reports　13　(1)　4985-4985　2023/03/27

    DOI： 10.1038/s41598-023-31861-9 　

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    There is little information about the reproducibility of the white coat effect, which was treated as a continuous variable. To investigate a long-term interval reproducibility of the white-coat effect as a continuous variable. We selected 153 participants without antihypertensive treatment (men, 22.9%; age, 64.4 years) from the general population of Ohasama, Japan, to assess the repeatedly measured white-coat effect (the difference between blood pressures at the office and home) in a 4-year interval. The reproducibility was assessed by testing the intraclass correlation coefficient (two-way random effect model-single measures). The white-coat effect for systolic/diastolic blood pressure slightly decreased by 0.17/1.56 mmHg at the 4-year visit on average. The Bland-Altman plots showed no significant systemic error for the white-coat effects (P ≥ 0.24). The intraclass correlation coefficient (95% confidence interval) of the white-coat effect for systolic blood pressure, office systolic blood pressure, and home systolic blood pressure were 0.41 (0.27-0.53), 0.64 (0.52-0.74), and 0.74 (0.47-0.86), respectively. Change in the white-coat effect was mainly affected by a change in office blood pressure. Long-term reproducibility of the white-coat effect is limited in the general population without antihypertensive treatment. The change in the white-coat effect is mainly caused by office blood pressure variation.

  124. Marital status, household size, and lifestyle changes during the first COVID-19 pandemic: NIPPON DATA2010

    Makiko Abe, Hisatomi Arima, Atsushi Satoh, Nagako Okuda, Hirokazu Taniguchi, Nobuo Nishi, Aya Higashiyama, Harumitsu Suzuki, Aya Kadota, Takayoshi Ohkubo, Hirotsugu Ueshima, Katsuyuki Miura, Akira Okayama, Shigeyuki Saitoh, Kiyomi Sakata, Atsushi Hozawa, Yosikazu Nakamura, Tomonori Okamura, Yoshitaka Murakami, Toshiyuki Ojima, Hideaki Nakagawa, Yoshikuni Kita, Yasuyuki Nakamura, Naomi Miyamatsu, Takehito Hayakawa, Katsushi Yoshita, Yoshihiro Miyamoto, Makoto Watanabe, Naoyuki Takashima, Akira Fujiyoshi, Kazunori Kodama, Fumiyoshi Kasagi, Yutaka Kiyohara, Toshiharu Ninomiya

    PLoS ONE　18　(3 March)　2023/03

    DOI： 10.1371/journal.pone.0283430 　

    eISSN： 1932-6203

  125. Association between the extent of house collapse and urine sodium-to-potassium ratio of victims affected by the 2011 Great East Japan Earthquake and Tsunami: a cross-sectional study

    Takahiro Mikami, Kozo Tanno, Ryohei Sasaki, Nobuyuki Takanashi, Yuka Kotozaki, Koichi Asahi, Fumitaka Tanaka, Shinichi Omama, Mana Kogure, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Atsushi Hozawa, Jiro Hitomi, Kiyomi Sakata, Makoto Sasaki

    Hypertension Research　2023/02/17

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41440-023-01190-5 　

    ISSN： 0916-9636

    eISSN： 1348-4214

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    Abstract People who experience natural disasters have a high risk of developing cardiovascular diseases. We investigated the association between the extent of house collapse and urine sodium-to-potassium (UNa/K) ratio of 2011 Great East Japan Earthquake victims. We used the baseline survey data of the Tohoku Medical Megabank Project Community-Based Cohort Study of 29 542 individuals (aged 20–74 years) residing in the affected areas. The UNa/K ratio was calculated using spot urinary electrolyte values. Analysis of covariance was used to calculate the multivariate-adjusted geometric means of the UNa/K ratio in the following groups stratified according to the self-reported extent of house collapse: total collapse (TC), half collapse (HC), partial collapse (PC), and no damage (ND). Multivariable-adjusted odds ratios (ORs) for a high UNa/K ratio were calculated using logistic regression. The TC, HC, PC, and ND groups comprised 5 359 (18.1%), 3 576 (12.1%), 7 331 (24.8%), and 13 276 (44.9%) participants, respectively. The TC (3.33; 95% confidence interval [CI], 3.28–3.38), HC (3.37; 3.30–3.43), and PC (3.32; 3.28–3.37) groups had significantly higher multivariate-adjusted geometric means of the UNa/K ratio than the ND (3.24; 3.21–3.27) group. The multivariable-adjusted ORs (95% CIs) for a high UNa/K ratio in the TC, HC, and PC groups vs. the ND group were 1.07 (0.99–1.15), 1.20 (1.11–1.31), and 1.20 (1.12–1.28), respectively. Similar associations between house collapse and UNa/K ratio were observed for both sexes. We report that victims of a natural disaster tend to have a diet with high sodium-to-potassium ratio.

  126. Carotid Intima Media Thickness and Risk Factor for Atherosclerosis: Tohoku Medical Megabank Community-Based Cohort Study.

    Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

    Journal of atherosclerosis and thrombosis　2023/02/11

    DOI： 10.5551/jat.64039 　

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    AIM: We examined the association between the carotid intima medica thickness (cIMT) and risk factors for atherosclerosis based on the Japan Atherosclerosis Society 2022 Atherosclerosis Prevention Guideline. METHODS: Using data from the Tohoku Medical Megabank Community-based Cohort Study, we performed a cross-sectional study that enrolled 13,366 participants (age ≥ 20 years) with an analysis of covariance to assess associations between cIMT and risk factors for atherosclerosis. The maximum common carotid artery was measured using high-resolution B-mode ultrasound. Analysis was conducted in the model adjusted for age, sex, smoking status, drinking status, body mass index (BMI), systolic blood pressure (SBP), glycated hemoglobin (HbA1c), high-density lipoprotein-cholesterol (HDL-C), non-high-density lipoprotein-cholesterol (non-HDL-C), and height. RESULTS: In this study cohort, the average age and cIMT were 57.3 (13.8) years and 0.61 (0.13) mm, respectively, which included 3,988 males (29.8%). Males had a higher cIMT than did the females. Age, height, BMI, SBP, HbA1c, and non-HDL-C were positively associated with cIMT. HDL-C was inversely associated with cIMT. Compared with never drinkers, current drinkers (≥ 46.0 g/day) had a significantly decreased cIMT. CONCLUSIONS: The cIMT was associated with atherosclerosis risk factors including age, sex, BMI, SBP, HbA1c, non-HDL-C, and HDL-C, and adequate control of risks in high-risk individuals might be required to prevent atherosclerotic cardiovascular diseases.

  127. 背景因子とAIS得点を考慮したCES-D陽性の推定有病率の可視化

    松山 崇, 成田 暁, 高梨 昌樹, 小暮 真奈, 佐藤 守一, 中村 智洋, 中根 英雄, 荻島 創一, 長神 風二, 中谷 直樹, 丹野 高三, 今枝 孝夫, 寳澤 篤

    Journal of Epidemiology　33　(Suppl.1)　118-118　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  128. 地域在住高齢者の自己報告による視覚障害と要介護発生との関連 鶴ヶ谷プロジェクト

    小幡 紘輝, 鈴鴨 よしみ, 宮武 ミドリ, 永富 良一, 小暮 真奈, 中谷 直樹, 寳澤 篤, 出江 紳一

    Journal of Epidemiology　33　(Suppl.1)　149-149　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  129. BMI・飲酒・尿Na/K比と高血圧の関連における両親の高血圧既往の影響

    平田 匠, 小暮 真奈, 畑中 里衣子, 千葉 一平, 中谷 久美, 菅野 郁美, 中村 智洋, 小原 拓, 中谷 直樹, 栗山 進一, 辻 一郎, 寳澤 篤

    Journal of Epidemiology　33　(Suppl.1)　155-155　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  130. 脂肪量指数と除脂肪量指数の組み合わせと呼吸機能検査指標の関連

    高瀬 雅仁, 山田 充啓, 中村 智洋, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 布施 昇男, 栗山 進一, 辻 一郎, 寳澤 篤

    Journal of Epidemiology　33　(Suppl.1)　155-155　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  131. 糖尿病指標と嗅覚機能の関連

    佐竹 芽久美, 菅野 郁美, 佐藤 守一, 今枝 孝夫, 高梨 昌樹, 早川 和美, 中谷 久美, 千葉 一平, 小暮 真奈, 畑中 里衣子, 斉藤 智, 中村 智洋, 長神 風二, 荻島 創一, 布施 昇男, 麦倉 俊司, 栗山 進一, 中谷 直樹, 寳澤 篤

    Journal of Epidemiology　33　(Suppl.1)　156-156　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  132. 東北メディカル・メガバンク計画地域住民コホート調査(宮城)詳細二次調査の概要

    中谷 久美, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 千葉 一平, 菅野 郁美, 中村 智洋, 小原 拓, 宇留野 晃, 布施 昇男, 辻 一郎, 栗山 進一, 寳澤 篤

    Journal of Epidemiology　33　(Suppl.1)　173-173　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  133. 血清メタボロームと認知機能変化の関連 NILS-LSAの観察結果から

    寳澤 篤, 大塚 礼, 張 シュ, 菱沼 英史, 元池 育子, 三枝 大輔, 中谷 直樹, 小柴 生造, 荒井 秀典

    Journal of Epidemiology　33　(Suppl.1)　87-87　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  134. Association between lung function and hypertension and home hypertension in a Japanese population: the Tohoku Medical Megabank Community-Based Cohort Study. International-journal

    Masato Takase, Mitsuhiro Yamada, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

    Journal of hypertension　41　(3)　443-52　2023/01/04

    DOI： 10.1097/HJH.0000000000003356 　

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    BACKGROUND: Although several studies have shown an inverse association between lung function and hypertension, few studies have examined the association between lung function and hypertension among never-smokers, and no study has investigated the association between lung function and home hypertension. We investigated the associations between lung function and hypertension in a Japanese population. INDIVIDUALS AND METHODS: We conducted a cross-sectional study of 3728 men and 8795 women aged 20 years or older living in Miyagi Prefecture, Japan. Lung function was assessed using forced expiratory volume at 1 s (FEV1) and forced vital capacity (FVC), measured by spirometry. Hypertension was defined as a casual blood pressure at least 140/90 mmHg and/or self-reported treatment for hypertension. Home hypertension was defined as morning home blood pressure at least 135/85 mmHg and/or self-reported treatment for hypertension. Multivariate logistic regression models adjusted for potential confounders were used to assess the association between lung function and hypertension. RESULTS: The mean ages (±SD) of men and women were 60.1 (±14.0) years and 56.2 (±13.4) years, respectively, and 1994 (53.5%) men and 2992 (34.0%) women had hypertension. In the multivariable models, FEV1 and FVC were inversely associated with hypertension. Inverse associations between lung function and hypertension were observed even among never-smokers. Furthermore, reduced lung function was associated with higher prevalence of home hypertension in men and women. CONCLUSION: Reduced lung function was associated with higher prevalence of hypertension, independent of smoking status. Assessment of the lung function or blood pressure may be required in individuals with reduced lung function or hypertension.

  135. A knowledge representation model for family relationship to three generation Peer-reviewed

    Kazuro Shimokawa, Mami Ishikuro, Taku Obara, Hirohito Metoki, Satoshi Mizuno, Satoshi Nagaie, Masato Nagai, Chizuru Yamanaka, Hiroko Matsubara, Mayumi Kato, Yuki Sato, Soichi Ogishima, Takako Takai, Masahiro Kikuya, Atsushi Hozawa, Fuji Nagami, Shinichi Kuriyama, Takashi Suzuki, Kengo Kinoshita, Masayuki Yamamoto, Hiroshi Tanaka

    Bioinformation　18　(12)　1166-1172　2022/12/31

    Publisher: Biomedical Informatics

    DOI： 10.6026/973206300181166 　

    ISSN： 0973-8894

    eISSN： 0973-2063

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    A system for inputting and storing family information, named “BirThree Enrollment,” was developed to promote a birth and three-generation cohort study (BirThree Cohort Study). In this cohort study, it was necessary to satisfy many operational demands while constantly overwriting and changing input information. Complex kinship information must be quickly and accurately inputed and corrected, and information on those families not yet recruited must be retrieved. For these purposes, many devices are needed, from an input interface to the internal data structure. In the field of genetic statistics, a simple standard expressive form (describe father-child relation and mother-child relation) is used for describing family structure. However, this form doesn't have sufficient information. So we developed a new form in conducting the BirThree Cohort Study. Hence, we expanded the data structure, and constructed the Input control system. Family pedigree information is stored along with initial clinical information, and this enabled the input of all self-reported information to the data base. Operators are able to input this family information before the day is out. As a result, when recruitment is completed, family information will be completed concurrently. Therefore, operators can immediately know certain person's family structure. In this model data correction was improved dramatically, and the system was operated successfully. This study is the first report of the method for storing three generations of family data.

  136. Investigation of the urinary sodium-to-potassium ratio target level based on the recommended dietary intake goals for the Japanese population: The INTERMAP Japan. International-journal

    Ebtehal Salman, Aya Kadota, Yukiko Okami, Keiko Kondo, Katsushi Yoshita, Nagako Okuda, Hideaki Nakagawa, Shigeyuki Saitoh, Kiyomi Sakata, Akira Okayama, Queenie Chan, Paul Elliott, Jeremiah Stamler, Hirotsugu Ueshima, Katsuyuki Miura

    Hypertension research : official journal of the Japanese Society of Hypertension　45　(12)　1850-1860　2022/12

    DOI： 10.1038/s41440-022-01007-x 　

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    Growing epidemiological evidence has shown an association of the urinary sodium (Na) to potassium (K) ratio (Na/K ratio) with blood pressure and cardiovascular diseases. However, no clear cutoff level has been defined. We investigated the cutoff level of the urinary Na/K ratio under different dietary guidelines for Japanese individuals, especially that endorsed by the 2020 revised Japanese Dietary Reference Intakes (DRIs). A population of 1145 Japanese men and women aged 40 to 59 years from the INTERMAP study was examined. Using high-quality standardized data, the averages of two 24 h urinary collections and four 24 h dietary recalls were used to calculate the 24 h urinary and dietary Na/K ratios, respectively. Associations between the urinary and dietary Na/K ratios were tested by sex- and age-adjusted partial correlation. The optimal urinary Na/K ratio cutoff level was determined by receiver operating characteristic (ROC) curves and sex-specific cross tables for recommended dietary K and salt. Overall, the average molar ratio of 24 h urinary Na/K was 4.3. We found moderate correlations (P < 0.001) of the 24 h urinary Na/K ratio with 24 h urinary Na and K excretion (r = 0.52, r = -0.49, respectively) and the dietary Na/K ratio (r = 0.53). ROC curves showed that a 24 h urinary Na/K ratio of approximately 2 predicted Na and K intake that meets the dietary goals of the Japanese DRIs. The range of urinary Na/K ratios meeting the dietary goals of the Japanese DRIs for both Na and K was 1.6‒2.2 for men and 1.7‒1.9 for women. Accomplishing a urinary Na/K ratio of 2 would be desirable to achieve the DRIs dietary goals for both Na and K simultaneously in middle-aged Japanese men and women accustomed to Japanese dietary habits. This observational study is registered at www.clinicaltrials.gov as NCT00005271.

  137. Circulating plasma phospholipid fatty acid levels as a biomarker of habitual dietary fat intake: The INTERMAP/INTERLIPID Study. International-journal

    Naoko Miyagawa, Akira Sekikawa, Katsuyuki Miura, Rhobert W Evans, Nagako Okuda, Akira Fujiyoshi, Katsushi Yoshita, Queenie Chan, Yukiko Okami, Aya Kadota, Bradley Willcox, Kamal Masaki, Beatriz Rodriguez, Kiyomi Sakata, Hideaki Nakagawa, Shigeyuki Saitoh, Akira Okayama, Lewis H Kuller, Paul Elliott, Jeremiah Stamler, Hirotsugu Ueshima

    Journal of clinical lipidology　17　(1)　131-141　2022/11/17

    DOI： 10.1016/j.jacl.2022.11.003 　

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    BACKGROUND: Accurate assessment of fat intake is essential to examine relationships between diet and disease risk. However, estimating individual intakes of fat quantity by dietary assessment is difficult. OBJECTIVE: We assessed the association of plasma phospholipid fatty acid levels with dietary intake of fatty acids in the INTERMAP/INTERLIPID study, conducted with a standardized protocol. METHODS: The study participants were 1339 men and women ages 40-59 years from five Japanese populations one from Hawaii; four from Japan. Fatty acid intake was estimated from four standardized 24-hour dietary recalls. Plasma phospholipid fatty acid composition was analyzed by gas chromatography. We illustrated the relationship between intake and circulating fatty acid levels using Spearman's rank-correlation coefficients, mean, and median values. RESULTS: Spearman's rank-correlation coefficients between intake (g/d) and circulating fatty acid levels (µg/ml) were -0.03 to 0.21 for saturated fatty acids and monounsaturated fatty acids and -0.04 to 0.32 for trans fatty acids. The coefficients for essential n-3 and n-6 fatty acids were moderate to high, especially for eicosapentaenoic acid (EPA), 0.60; docosahexaenoic acid (DHA), 0.41; and EPA+DHA, 0.51. The circulating levels and intake of marine-derived n-3 fatty acids showed a linear association, at least for the intake of EPA+DHA up to 2.1 g/d. CONCLUSION: We observed high correlation between intake and circulating levels of marine-derived n-3 fatty acids in participants from Japanese and Japanese-American populations with high and low fish intake. Plasma phospholipid marine-derived n-3 fatty acid measurements are a simple and reliable biomarker for assessing dietary intake.

  138. The Association of Lung Function and Carotid Intima-Media Thickness in a Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study.

    Masato Takase, Mitsuhiro Yamada, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

    Journal of atherosclerosis and thrombosis　2022/11/04

    DOI： 10.5551/jat.63826 　

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    AIM: Impaired lung function is associated with atherosclerotic vascular events. Carotid intima-media thickness (cIMT) is a marker for subclinical atherosclerosis. However, few studies have examined the association between lung function and cIMT among never smokers or individuals stratified by age. We investigated the association between lung function and cIMT in the Japanese population. METHODS: We conducted a cross-sectional study of 3,716 men and 8,765 women aged 20 years or older living in Miyagi Prefecture, Japan. Lung function was evaluated using forced expiratory volume at 1 s (FEV1) and forced vital capacity (FVC) was measured using spirometry. The maximum common carotid artery was measured using high-resolution B-mode ultrasound. An analysis of covariance was used to assess associations between lung function and cIMT and adjusted for potential confounders. A linear trend test was conducted by scoring the categories from 1 (lowest) to 4 (highest) and entering the score as a continuous term in the regression model. RESULTS: After adjusting for potential confounders including passive smoking, lower FEV1 and FVC were associated with higher cIMT in both men and women (P＜0.001 for linear trend). This association was confirmed even when we restricted our study to never smokers. Furthermore, even when we stratified by age, an inverse association between lung function and cIMT was confirmed in middle-aged (40-64 years) and elderly participants (65-74 years). CONCLUSIONS: Lower lung function was associated with higher cIMT in the Japanese population independent of age and smoking. Assessment of atherosclerosis or lung function may be required for individuals with lower lung function or atherosclerosis.

  139. Small High-Density Lipoprotein and Omega-3 Fatty Acid Intake Differentiates Japanese and Japanese-Americans: The INTERLIPID Study.

    Yukiko Okami, Queenie Chan, Katsuyuki Miura, Aya Kadota, Paul Elliott, Kamal Masaki, Akira Okayama, Nagako Okuda, Katsushi Yoshita, Naoko Miyagawa, Tomonori Okamura, Kiyomi Sakata, Shigeyuki Saitoh, Masaru Sakurai, Hideaki Nakagawa, Jeremiah Stamler, Hirotsugu Ueshima

    Journal of atherosclerosis and thrombosis　30　(8)　884-906　2022/11/03

    DOI： 10.5551/jat.63762 　

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    AIM: To identify the most differentiated serum lipids, especially concerning particle size and fractions, between Japanese living in Japan and Japanese-Americans in Hawaii, in the absence of possible genetic confounders, and cross-sectionally examine the associated modifiable lifestyle factors. METHODS: Overall, 1,241 (aged 40-59 years) Japanese living in Japan and Japanese-Americans in Hawaii were included. We quantified 130 serum lipid profiles (VLDL 1-5, IDL, LDL 1-6, high-density lipoprotein [HDL] 1-4, and their subfractions) using Bruker's 1 H-nuclear magnetic resonance spectrometer for the primary outcome. Modifiable lifestyle factors included body mass index (BMI), physical activity, alcohol and smoking habits, and 70 nutrient parameters. We evaluated the different lipids between the groups using partial least squares-discriminant analysis and association between extracted lipids and lifestyle factors using multivariable linear regression analysis. RESULTS: Concentrations of HDL4, HDL with the smallest particle size, were lower in Japanese than in Japanese-Americans of both sexes. Higher fish-derived omega-3 fatty acid intake and lower alcohol intake were associated with lower HDL4 concentrations. A 1% higher kcal intake of total omega-3 fatty acids was associated with a 9.8- mg/dL lower HDL4. Fish-derived docosapentaenoic acid, eicosapentaenoic acid, and docosahexaenoic acid intake were inversely associated with HDL4 concentration. There was no relationship between country, sex, age, or BMI. CONCLUSIONS: Japanese and Japanese-Americans can be differentiated based on HDL4 concentration. High fish intake among the Japanese may contribute to their lower HDL4 concentration. Thus, HDL particle size may be an important clinical marker for coronary artery diseases or a fish consumption biomarker.

  140. Association between ambulatory blood pressure and risk of home hypertension in a normotensive population: the Ohasama Study. International-journal

    Shingo Nakayama, Michihiro Satoh, Hirohito Metoki, Takahisa Murakami, Yukako Tatsumi, Kei Asayama, Azusa Hara, Takuo Hirose, Megumi Tsubota-Utsugi, Masahiro Kikuya, Takefumi Mori, Atsushi Hozawa, Yutaka Imai, Takayoshi Ohkubo

    American journal of hypertension　36　(3)　151-158　2022/10/30

    DOI： 10.1093/ajh/hpac121 　

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    BACKGROUND: We investigated the association between ambulatory blood pressure (BP) and the risk of home hypertension in a normotensive population and whether considering ambulatory BP improves the 10-year prediction model for home hypertension risk, which was developed in the previous Ohasama Study. METHODS: In this prospective study, we followed up 410 participants (83.2% women; age, 53.6 years) without home and ambulatory hypertension in the general population of Ohasama, Japan. The Cox model was used to assess the hazard ratios for home hypertension (home BP ≥135/≥85 mmHg or initiation of antihypertensive treatment) and model improvement. RESULTS: During a mean 14.2-year follow-up, 225 home hypertension incidences occurred. The hazard ratio (95% confidence interval) for home hypertension incidence per 1-standard deviation higher (=6.76 mmHg) 24-h systolic BP was 1.59 (1.33-1.90), after adjustments for possible confounding factors, including baseline home systolic BP. Harrell's C-statistics increased from 0.72 to 0.73 (P=0.11) when 24-h systolic BP was added to the basic 10-year home hypertension prediction model, which includes sex, age, body mass index, smoking status, office systolic BP, and baseline home systolic BP. Continuous net reclassification improvement (0.53, P<0.0001) and integrated discrimination improvement (0.028, P=0.0014) revealed improvement in the model. CONCLUSIONS: 24-h systolic BP could be an independent predictor of future home hypertension. Home BP and 24-h BP can longitudinally influence each other in the long term.

  141. Similarities in cardiometabolic risk factors among random male-female pairs: a large observational study in Japan. International-journal

    Naoki Nakaya, Kumi Nakaya, Naho Tsuchiya, Toshimasa Sone, Mana Kogure, Rieko Hatanaka, Ikumi Kanno, Hirohito Metoki, Taku Obara, Mami Ishikuro, Atsushi Hozawa, Shinichi Kuriyama

    BMC public health　22　(1)　1978-1978　2022/10/28

    DOI： 10.1186/s12889-022-14348-6 　

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    BACKGROUND: Previous observational studies have shown similarities in cardiometabolic risk factors between spouses. It is still possible that this result reflects the age similarity of spouses rather than environmental factors of spouses (e.g. cohabitation effect). To clarify the importance of mate cardiometabolic risk factors for similarity of environmental factors, it is necessary to examine whether they are observed in random male-female pairs while maintaining the age of the spousal pairs. This study aimed to determine whether the similarities found between spousal pairs for cardiometabolic risks were also observed between random male-female pairs. METHODS: This cross-sectional study included 5,391 spouse pairs from Japan; data were obtained from a large biobank study. For pairings, women of the same age were randomly shuffled to create new male-female pairs of the same age as that of the original spouse pairs. Similarities in cardiometabolic risk factors between the random male-female pairs were analysed using Pearson's correlation or age-adjusted logistic regression analyses. RESULTS: The mean ages of the men and women were 63.2 and 60.4 years, respectively. Almost all cardiometabolic risk factors similarities were not noted in cardiometabolic risk factors, including the continuous risk factors (anthropometric traits, blood pressure, glycated haemoglobin level, and lipid traits); lifestyle habits (smoking, drinking, and physical activity); or diseases (hypertension, type 2 diabetes mellitus, and metabolic syndrome) between the random male-female pairs. The age-adjusted correlation coefficients ranged from - 0.007 for body mass index to 0.071 for total cholesterol. The age-adjusted odds ratio (95% confidence interval) for current drinkers was 0.94 (0.81 - 1.09); hypertension, 1.07 (0.93 - 1.23); and type 2 diabetes mellitus, 1.08 (0.77 - 1.50). CONCLUSION: In this study, few similarities in cardiometabolic risk factors were noted among the random male-female pairs. As spouse pairs may share environmental factors, intervention strategies targeting lifestyle habits and preventing lifestyle-related diseases may be effective.

  142. Visualization of estimated prevalence of CES-D positivity accounting for background factors and AIS scores. International-journal

    Takashi Matsuyama, Akira Narita, Masaki Takanashi, Mana Kogure, Shuichi Sato, Tomohiro Nakamura, Hideo Nakane, Soichi Ogishima, Fuji Nagami, Naoki Nakaya, Kozo Tanno, Takao Imaeda, Atsushi Hozawa

    Scientific reports　12　(1)　17656-17656　2022/10/21

    DOI： 10.1038/s41598-022-22266-1 　

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    Development of methods for population screening is necessary to improve the efficiency of secondary prevention of diseases. Until now, a common cutoff has been used for all people in the data set. However, if big data for health information can be used to modify individual cutoffs according to background factors, it may avoid wasting medical resources. Here we show that the estimated prevalence of the Center for Epidemiologic Studies Depression Scale positivity can be visualized by a heatmap using background factors from epidemiological big data and scores from the Athens Insomnia Scale. We also show that cutoffs based on the estimated prevalence can be used to decrease the number of people screened without decreasing the number of prevalent cases detected. Since this method can be applied to the screening of different outcomes, we believe our work can contribute to the development of efficient screening methods for various diseases.

  143. Female Reproductive Events and Subclinical Atherosclerosis of the Brain and Carotid Arteriopathy: the Ohasama Study.

    Wakana Sato, Kyoko Nomura, Michihiro Satoh, Azusa Hara, Megumi Tsubota-Utsugi, Takahisa Murakami, Kei Asayama, Yukako Tatsumi, Yuki Kobayashi, Takuo Hirose, Ryusuke Inoue, Tomoko Totsune, Masahiro Kikuya, Atsushi Hozawa, Hirohito Metoki, Yutaka Imai, Hiroyuki Watanabe, Takayoshi Ohkubo

    Journal of atherosclerosis and thrombosis　30　(8)　956-978　2022/10/05

    DOI： 10.5551/jat.63592 　

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    AIMS: Few studies have investigated the subclinical atherosclerotic changes in the brain and carotid artery, and in East Asian populations. We sought to investigate whether gravidity, delivery, the age at menarche and menopause and estrogen exposure period are associated with subclinical atherosclerosis of the brain and carotid arteriopathy. METHODS: This cross-sectional study formed part of a cohort study of Ohasama residents initiated in 1986. Brain atherosclerosis and carotid arteriopathy were diagnosed as white matter hyperintensity (WMH) and lacunae evident on brain magnetic resonance imaging (MRI) and carotid intimal media thickness (IMT) or plaque revealed by ultrasound, respectively. The effect of the reproductive events on brain atherosclerosis and carotid arteriopathy was investigated using logistic regression and general linear regression models after adjusting for covariates. RESULTS: Among 966 women aged ≥ 55 years in 1998, we identified 622 and 711 women (mean age: 69.2 and 69.7 years, respectively) who underwent either MRI or carotid ultrasound between 1992-2008 or 1993-2018, respectively. The highest quartile of gravidity (≥ 5 vs. 3) and delivery (≥ 4 vs. 2), and the highest and second highest (3 vs. 2) quartiles of delivery were associated with an increased risk of WMH and carotid artery plaque, respectively. Neither of age at menarche, menopause, and estrogen exposure period estimated by subtracting age at menarche from age at menopause was associated with atherosclerotic changes of brain and carotid arteries. CONCLUSIONS: Higher gravidity and delivery are associated with subclinical atherosclerosis of the brain and carotid plaque.

  144. 東北メディカル・メガバンク計画三世代コホート調査 概要と進捗

    小原 拓, 石黒 真美, 村上 慶子, 上野 史彦, 野田 あおい, 大沼 ともみ, 松崎 芙実子, 中谷 直樹, 寳澤 篤, 菅原 準一, 栗山 進一

    DOHaD研究　10　(2)　80-80　2022/10

    Publisher: (一社)日本DOHaD学会

    ISSN： 2187-2562

    eISSN： 2187-2597

  145. 地域在住高齢者の予測努力肺活量と肺炎死の関連および筋力と血清総コレステロール値の影響

    汐川 菜々子, 岡崎 達馬, 鈴鴨 よしみ, 宮武 ミドリ, 海老原 覚, 小暮 真奈, 中谷 直樹, 寳澤 篤, 出江 紳一

    The Japanese Journal of Rehabilitation Medicine　59　(秋季特別号)　S444-S444　2022/10

    Publisher: (公社)日本リハビリテーション医学会

    ISSN： 1881-3526

    eISSN： 1881-8560

  146. Association between glycemic traits and primary open-angle glaucoma: A Mendelian randomization study in the Japanese population. International-journal

    Akiko Hanyuda, Atsushi Goto, Masahiro Nakatochi, Yoichi Sutoh, Akira Narita, Shiori Nakano, Ryoko Katagiri, Kenji Wakai, Naoyuki Takashima, Teruhide Koyama, Kokichi Arisawa, Issei Imoto, Yukihide Momozawa, Kozo Tanno, Atsushi Shimizu, Atsushi Hozawa, Kengo Kinoshita, Taiki Yamaji, Norie Sawada, Masao Iwagami, Kenya Yuki, Kazuo Tsubota, Kazuno Negishi, Keitaro Matsuo, Masayuki Yamamoto, Makoto Sasaki, Shoichiro Tsugane, Motoki Iwasaki

    American journal of ophthalmology　245　193-201　2022/09/23

    DOI： 10.1016/j.ajo.2022.09.004 　

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    PURPOSE: A meta-analysis suggests a relationship between abnormal glucose metabolism and primary open-angle glaucoma (POAG); however, the causal association between them remains controversial. We therefore conducted a Mendelian randomization (MR) study to assess the causal association between genetically predicted glycemic traits and the risk of POAG. DESIGN: Two-sample MR design. METHODS: We examined the genetically predicted measures of fasting glucose, hemoglobin A1c (HbA1c), and fasting C-peptide, in relation to POAG. For the single nucleotide polymorphism (SNP)-exposure analyses, we meta-analyzed the study-level genome-wide associations of fasting glucose levels (n=17,289; n of SNPs=34), HbA1c (n=52,802; n of SNPs=43), and fasting C-peptide levels (n=1,666; n of SNPs=17) from the Japanese Consortium of Genetic Epidemiology studies. We used summary statistics from the BioBank Japan projects (n=3,980 POAG cases and 18,815 controls) for the SNP-outcome association. RESULTS: We observed no association of genetically predicted HbA1c and fasting C-peptide with POAG. The MR inverse-variance weighted (IVW) odds ratios (ORs) were 1.44 (95% confidence interval [CI], 0.78-2.65; P=0.25) for HbA1c (per 1 % increment) and 0.92 (95% CI, 0.56-1.53; P=0.76) for fasting C-peptide (per two-fold increment). A significant association between fasting glucose (per 10 mg/dL increment) and POAG was observed according to the MR IVW analysis (OR=1.48 [95% CI, 1.10-1.79, P=0.009]); however, sensitivity analyses, including MR-Egger and weighted-median methods, did not support this association (P>0.10). CONCLUSIONS: We did not provide strong evidence to support the association between genetically predicted glycemic traits and POAG in the Japanese population.

  147. Home Blood Pressure-based Guidance Did not Increase Anti-albuminuric Effects on Diagnostic Provision of Microalbuminuria in School Workers: A Miyagi Karoshi Prevention Study.

    Masanori Munakata, Tomomi Hattori, Fumie Kubota-Nakayama, Satoshi Konno, Nobutaka Inoue, Tomohiro Nakamura, Atsushi Hozawa

    Internal medicine (Tokyo, Japan)　2022/09/13

    DOI： 10.2169/internalmedicine.0107-22 　

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    Objective We examined whether home blood pressure (BP)-based behavioural guidance had an additional anti-albuminuric effect on school workers with the simple diagnostic provision of microalbuminuria. Methods Of 169 school staff diagnosed with microalbuminuria (30-299.9 mg/gCr) in the annual 2019 health check-up, 91 agreed to receive home-BP-based guidance. Guidance comprised, for subjects with ≥ 135/85 mmHg, 5 days mean of home BP measurements, or encouraging medical consultation and lifestyle guidance; lifestyle guidance for subjects with BP 125-134/80-84 mmHg; and adequate lifestyle guidance for subjects BP<125/80 mmHg, if necessary. The main outcome was a change in the frequency of microalbuminuria the following year. Subjects with menstruation were excluded from analysis. Finally, there were 48 and 43 participants in guided and the non-guided groups, respectively. Results The guided and non-guided groups demonstrated similar baseline clinical data. Their prescription rates for hypertension (39.6 vs. 41.9 %) and diabetes (18.8 vs. 30.2 %) were similar. One year later, microalbuminuria was present in 31.2% and 30.2% of the guided and non-guided groups (n.s.), respectively, suggesting a ~70% risk reduction of microalbuminuria in both groups. Sensitivity analysis, excluding patients treated for hypertension or diabetes at baseline, demonstrated essentially similar results. In conclusion, the risk reduction of microalbuminuria was nearly 70% for both the home-BP-based guidance and non-guidance groups. Conclusion These data suggest that home BP-based guidance did not increase anti-albuminuric effects on simple diagnostic provision of microalbuminuria in school workers.

  148. Development of a method for walking step observation based on large-scale GPS data. International-journal

    Shohei Nagata, Tomoki Nakaya, Tomoya Hanibuchi, Naoki Nakaya, Atsushi Hozawa

    International journal of health geographics　21　(1)　10-10　2022/09/07

    DOI： 10.1186/s12942-022-00312-5 　

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    BACKGROUND: Widespread use of smartphones has enabled the continuous monitoring of people's movements and physical activity. Linking global positioning systems (GPS) data obtained via smartphone applications to physical activity data may allow for large-scale and retrospective evaluation of where and how much physical activity has increased or decreased due to environmental, social, or individual changes caused by policy interventions, disasters, and infectious disease outbreaks. However, little attention has been paid to the use of large-scale commercial GPS data for physical activity research due to limitations in data specifications, including limited personal attribute and physical activity information. Using GPS logs with step counts measured by a smartphone application, we developed a simple method for daily walking step estimation based on large-scale GPS data. METHODS: The samples of this study were users whose GPS logs were obtained in Sendai City, Miyagi Prefecture, Japan, during October 2019 (37,460 users, 36,059,000 logs), and some logs included information on daily step counts (731 users, 450,307 logs). The relationship between land use exposure and daily step counts in the activity space was modeled using the small-scale GPS logs with daily step counts. Furthermore, we visualized the geographic distribution of estimated step counts using a large set of GPS logs with no step count information. RESULTS: The estimated model showed positive relationships between visiting high-rise buildings, parks and public spaces, and railway areas and step counts, and negative relationships between low-rise buildings and factory areas and daily step counts. The estimated daily step counts tended to be higher in urban areas than in suburban areas. Decreased step counts were mitigated in areas close to train stations. In addition, a clear temporal drop in step counts was observed in the suburbs during heavy rainfall. CONCLUSIONS: The relationship between land use exposure and step counts observed in this study was consistent with previous findings, suggesting that the assessment of walking steps based on large-scale GPS logs is feasible. The methodology of this study can contribute to future policy interventions and public health measures by enabling the retrospective and large-scale observation of physical activity by walking.

  149. 東日本大震災による自宅の被害状況と高血圧治療中断との関連

    畑中 里衣子, 中谷 直樹, 小暮 真奈, 中谷 久美, 千葉 一平, 菅野 郁美, 中村 智洋, 後岡 広太郎, 小原 拓, 布施 昇男, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集　81回　196-196　2022/09

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  150. 過敏性腸症候群の有病に関連する要因の検討 TMM計画地域住民コホート調査

    中谷 久美, 中谷 直樹, 永家 聖, 小暮 真奈, 畑中 里衣子, 千葉 一平, 菅野 郁美, 小原 拓, 中村 智洋, 金澤 素, 荻島 創一, 栗山 進一, 辻 一郎, 寳澤 篤, 福土 審

    日本公衆衛生学会総会抄録集　81回　201-201　2022/09

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  151. 呼吸機能検査指標と高血圧有病との関連

    高瀬 雅仁, 山田 充啓, 中村 智洋, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 土屋 菜歩, 平田 匠, 布施 昇男, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集　81回　202-202　2022/09

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  152. 被災後住居形態と肝機能指標に関する横断研究

    相場 繁, 中谷 直樹, 小暮 真奈, 中谷 久美, 畑中 里衣子, 千葉 一平, 菅野 郁美, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集　81回　237-237　2022/09

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  153. 生活習慣病の既往がない者における食事パターンと受診行動および医療費の関連

    五十嵐 有香, 小暮 真奈, 鈴木 寿則, 畑中 里衣子, 中谷 久美, 菅野 郁美, 千葉 一平, 中村 智洋, 荻島 創一, 中谷 直樹, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集　81回　246-246　2022/09

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  154. 健康診査への尿ナトリウム/カリウム比測定導入から見えてきたことと今後の展開

    小暮 真奈, 佐々木 久美子, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 大川 亜美, 黒川 悦子, 永吉 翔, 志賀 利一, 清水 友紀子, 牛田 悠介, 上田 宏幸, 中谷 直樹, 寳澤 篤

    日本公衆衛生学会総会抄録集　81回　308-308　2022/09

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  155. 握力および脚伸展力で測定した各筋力と生理学的データの関連

    野路 慶明, 畑中 里衣子, 中谷 直樹, 小暮 真奈, 中谷 久美, 千葉 一平, 菅野 郁美, 中村 智洋, 布施 昇男, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集　81回　431-431　2022/09

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  156. 全ゲノム/全エキソーム解析による生殖細胞系列多型の探索 一般住民コホートにおけるBRCA遺伝子バリアントの探索及び結果の回付事業について(Exploration of BRCA1/2 gene variants in a general population cohort and return of genomic results to the participants)

    徳永 英樹, 安田 純, 島田 宗昭, 濱中 洋平, 重田 昌吾, 布施 昇男, 勝岡 史城, 荻島 創一, 山口 由美, 寳澤 篤, 川目 裕, 大根田 絹子, 青木 洋子, 山本 雅之, 八重樫 伸生

    日本癌学会総会記事　81回　S8-1　2022/09

    Publisher: (一社)日本癌学会

    ISSN： 0546-0476

  157. 呼吸機能検査指標と高血圧有病との関連

    高瀬 雅仁, 山田 充啓, 中村 智洋, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 土屋 菜歩, 平田 匠, 布施 昇男, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集　81回　202-202　2022/09

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  158. Reduction of Cardiovascular Events and Related Healthcare Expenditures through Achieving Population-Level Targets of Dietary Salt Intake in Japan: A Simulation Model Based on the National Health and Nutrition Survey International-journal Peer-reviewed

    Nayu Ikeda, Hitomi Yamashita, Jun Hattori, Hiroki Kato, Katsushi Yoshita, Nobuo Nishi

    Nutrients　14　(17)　3606-3606　2022/08/31

    Publisher: MDPI AG

    DOI： 10.3390/nu14173606 　

    eISSN： 2072-6643

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    Reducing population dietary salt intake is expected to help prevent cardiovascular disease and thus constrain increasing national healthcare expenditures in Japan’s super-aged society. We aimed to estimate the impact of achieving global and national salt-reduction targets (8, &lt;6, and &lt;5 grams/day) on cardiovascular events and national healthcare spending in Japan. Using published data including mean salt intake and systolic blood pressure from the 2019 National Health and Nutrition Survey, we developed a Markov model of a closed cohort of adults aged 40–79 years in 2019 (n = 66,955,000) transitioning among six health states based on the disease course of ischemic heart disease (IHD) and stroke. If mean salt intake were to remain at 2019 levels over 10 years, cumulative incident cases in the cohort would be approximately 2.0 million for IHD and 2.6 million for stroke, costing USD 61.6 billion for IHD and USD 104.6 billion for stroke. Compared with the status quo, reducing mean salt intake towards the targets over 10 years would avert 1–3% of IHD and stroke events and save up to 2% of related national healthcare costs. Attaining dietary salt-reduction goals among adults would yield moderate health economic benefits in Japan.

  159. Blood lipids and the risk of colorectal cancer: Mendelian randomization analyses in the Japanese Consortium of Genetic Epidemiology studies. International-journal

    Masao Iwagami, Atsushi Goto, Ryoko Katagiri, Yoichi Sutoh, Yuriko N Koyanagi, Masahiro Nakatochi, Shiori Nakano, Akiko Hanyuda, Akira Narita, Atsushi Shimizu, Kozo Tanno, Atsushi Hozawa, Kengo Kinoshita, Isao Oze, Hidemi Ito, Taiki Yamaji, Norie Sawada, Yohko Nakamura, Sho Nakamura, Kiyonori Kuriki, Sadao Suzuki, Asahi Hishida, Yumiko Kasugai, Issei Imoto, Midori Suzuki, Yukihide Momozawa, Kenji Takeuchi, Masayuki Yamamoto, Makoto Sasaki, Keitaro Matsuo, Shoichiro Tsugane, Kenji Wakai, Motoki Iwasaki

    Cancer prevention research (Philadelphia, Pa.)　15　(12)　827-836　2022/08/30

    DOI： 10.1158/1940-6207.CAPR-22-0146 　

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    The associations between blood lipids, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides, and low-density lipoprotein cholesterol (LDL-C), and colorectal cancer risk are controversial. We evaluated potential causal relationships between blood lipids and colorectal cancer risk. Using the baseline data from the Japanese Consortium of Genetic Epidemiology studies, we estimated the single-nucleotide polymorphism (SNP)-exposure associations (n=34,546 for TC, n=50,290 for HDL-C, n=51,307 for triglycerides, and n=30,305 for LDL-C). We also estimated the SNP-outcome associations in another Japanese dataset (n=7,936 colorectal cancer cases and n=38,042 controls). We conducted Mendelian randomization analyses for the association between each blood lipid type and the risk of colorectal cancer using an inverse variance-weighted method. The total variances explained by the selected SNPs in TC (68 SNPs), HDL-C (50 SNPs), log-transformed triglycerides (26 SNPs), and LDL-C (35 SNPs) were 7.0%, 10.0%, 6.2%, and 5.7%, respectively. The odds ratios for colorectal cancer were 1.15 (95% confidence interval 1.01-1.32) per 1 standard deviation (SD) (33.3 mg/dL) increase in TC, 1.11 (0.98-1.26) per 1 SD (15.4 mg/dL) increase in HDL-C, 1.06 (0.90-1.26) per 1 SD (0.5 log-mg/dL) increase in log-transformed triglycerides, and 1.17 (0.91-1.50) per 1 SD (29.6 mg/dL) increase in LDL-C. Sensitivity analyses consistently suggested the positive association between TC and colorectal cancer, whereas results of each lipid component were inconsistent. In conclusion, this large Mendelian randomization study of a Japanese population showed a potentially causal association between high TC and colorectal cancer risk, although the association between each lipid component and colorectal cancer remained inconclusive.

  160. 東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の進捗

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 小原 拓, 中村 智洋, 宇留野 晃, 布施 昇男, 泉 陽子, 丹野 高三, 辻 一郎, 栗山 進一, 寳澤 篤

    東北公衆衛生学会誌　(71)　28-28　2022/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  161. 尿ナトリウム/カリウム比と脳性ナトリウム利尿ペプチド 大迫研究

    室谷 智子, 佐藤 倫広, 村上 任尚, 中山 晋吾, 廣瀬 卓男, 橋本 英明, 遠山 真弥, 高畠 恭介, 辰巳 友佳子, 井上 隆輔, 坪田 恵[宇津木], 小暮 真奈, 中谷 直樹, 浅山 敬, 野村 恭子, 菊谷 昌浩, 目時 弘仁, 今井 潤, 寳澤 篤, 大久保 孝義

    東北公衆衛生学会誌　(71)　29-30　2022/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  162. Association of home and office systolic and diastolic hypertension with glucose metabolism in a general population: the Ohasama study. International-journal

    Yukako Tatsumi, Michihiro Satoh, Kei Asayama, Takahisa Murakami, Takuo Hirose, Azusa Hara, Megumi Tsubota-Utsugi, Ryusuke Inoue, Masahiro Kikuya, Kyoko Nomura, Hirohito Metoki, Atsushi Hozawa, Hideki Katagiri, Yutaka Imai, Takayoshi Ohkubo

    Journal of hypertension　40　(7)　1336-1343　2022/07/01

    DOI： 10.1097/HJH.0000000000003145 　

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    OBJECTIVE: This study was performed to investigate the association of hypertension subtypes with glucose metabolism among the Japanese general population. METHODS: The study involved 646 residents (mean age: 62.4 years) without treatment for hypertension or a history of diabetes from Ohasama, a rural Japanese community, who underwent an oral glucose tolerance test. Hypertension subtypes [normotension, isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), and systolic and diastolic hypertension (SDH)] were defined on the basis of home and office SBP and DBP (HBP and OBP, respectively). The estimated means of blood glucose related indices among the groups were compared by analysis of covariance adjusted for possible confounding factors. RESULTS: Blood glucose related indices were not different among the morning HBP-defined hypertension subtypes. Participants with evening HBP-defined ISH had a significantly higher estimated mean BG at 120 min, higher homeostasis model assessment-insulin resistance (HOMA-IR) and lower Matsuda-DeFronzo index than participants with NT (all P < 0.021). Participants with OBP-defined SDH had a significantly higher estimated mean fasting blood glucose; blood glucose at 30, 60 and 120 min; and HOMA-IR and a lower Matsuda-DeFronzo index than participants with NT (all P < 0.0025). CONCLUSION: The blood glucose related indices were different among hypertension subtypes. Participants with evening HBP-defined ISH and OBP-defined SDH had higher blood glucose levels and insulin resistance than participants with correspondingly defined normotension, while those with morning HBP did not. These findings suggest the importance of measuring evening HBP and office blood pressure for early detection of coexisting hypertension and diabetes.

  163. Relationship between the housing coldness/warmth evaluation by CASBEE Housing Health Checklist and psychological distress based on TMM Community-Based Cohort Study: a cross-sectional analysis. International-journal

    I Kanno, K Hasegawa, T Nakamura, M Kogure, F Itabashi, A Narita, N Tsuchiya, T Hirata, N Nakaya, J Sugawara, S Kuriyama, I Tsuji, S Kure, A Hozawa

    Public health　208　98-104　2022/07

    DOI： 10.1016/j.puhe.2022.05.003 　

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    OBJECTIVES: Previous studies have reported the relationship between housing environment and health, although due to cost and effort, it was difficult to conduct housing condition surveys on a large scale. The CASBEE Housing Health Checklist (the Checklist) made it possible to easily evaluate the housing condition from the resident's perspective. This study examined the relationship between housing coldness/warmth evaluation using the Checklist and psychological distress in a large-scale general Japanese population. STUDY DESIGN: A cross-sectional study. METHODS: We analysed data from 29,380 people aged ≥20 years who lived in Miyagi Prefecture, Japan. As an assessment of housing coldness/warmth, we used the Checklist. We classified participants' total scores on the Checklist related to coldness/warmth into quartiles. The Kessler 6 scale was used as an indicator of psychological distress. Multivariable logistic regression models were used to estimate the adjusted odds ratio (OR) and 95% confidence intervals (CIs). Adjusted OR and P-values for linear trends were calculated using the quartiles of the Checklists' score. RESULTS: Among participants in Q1 (i.e., poorer subjective house condition), the percentage of people with psychological distress was high. Compared to the highest quartile, Q1 showed poorer evaluation of housing coldness/warmth, and higher OR for psychological distress. The OR (95% CI) of psychological distress for Q3, Q2, and Q1 compared with Q4 were 1.93 (1.74-2.14), 2.82 (2.55-3.12), and 5.78 (5.25-6.35), respectively. CONCLUSIONS: Housing coldness/warmth evaluation was significantly related to psychological distress. This finding suggests that maintaining a comfortable thermal environment at home could be important for residents' mental health.

  164. Review of Mental Health Consequences of the Great East Japan Earthquake through Long-Term Epidemiological Studies: The Shichigahama Health Promotion Project.

    Yasuto Kunii, Hitomi Usukura, Yusuke Utsumi, Moe Seto, Yumiko Hamaie, Yumi Sugawara, Naoki Nakaya, Shinichi Kuriyama, Atsushi Hozawa, Ichiro Tsuji, Hiroaki Tomita

    The Tohoku journal of experimental medicine　257　(2)　85-95　2022/06/04

    DOI： 10.1620/tjem.2022.J039 　

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    After the Great East Japan Earthquake, Tohoku University began to provide mental health services during the acute phase of the disaster in cooperation with Shichigahama Town, one of the municipalities located in the coastal area of the Miyagi Prefecture that was severely damaged by the earthquake and tsunami; it continued to be providing long-term mental health activities, incorporating annual surveys for affected residents in the town for 10 years. Ten years of combination of surveys and outreach activities first depicted detailed longitudinal alterations in the mental health conditions of communities affected by a catastrophe. While posttraumatic stress reaction had recovered year by year after the year following the Great East Japan Earthquake, recovery from psychological distress retreated between 2014 and 2017, probably due to the relocation from temporal to eternal housing conditions. The annual cycles of assessment and provision of mental health support and promotion activities continued for 10 years can be an initial model for evidence-based, long-term post-disaster mental health and psychosocial support for the affected communities. Data regarding subsequent disasters should be collected in comparable ways, in order to improve the accuracy and usefulness of the accumulated data for planning and providing evidence-based post-disaster mental health and psychosocial support.

  165. Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations

    Gerard Temprano‐Sagrera, Colleen M. Sitlani, William P. Bone, Miguel Martin‐Bornez, Benjamin F. Voight, Alanna C. Morrison, Scott M. Damrauer, Paul S. de Vries, Nicholas L. Smith, Maria Sabater‐Lleal, Abbas Dehghan, Adam S Heath, Alanna C Morrison, Alex P Reiner, Andrew Johnson, Anne Richmond, Annette Peters, Astrid van Hylckama Vlieg, Barbara McKnight, Bruce M Psaty, Caroline Hayward, Cavin Ward‐Caviness, Christopher O’Donnell, Daniel Chasman, David P Strachan, David A Tregouet, Dennis Mook‐Kanamori, Dipender Gill, Florian Thibord, Folkert W Asselbergs, Frank W.G. Leebeek, Frits R Rosendaal, Gail Davies, Georg Homuth, Gerard Temprano, Harry Campbell, Herman A Taylor, Jan Bressler, Jennifer E Huffman, Jerome I Rotter, Jie Yao, James F Wilson, Joshua C Bis, Julie M Hahn, Karl C Desch, Kerri L Wiggins, Laura M Raffield, Lawrence F Bielak, Lisa R Yanek, Marcus E Kleber, Maria Sabater‐Lleal, Martina Mueller, Maryam Kavousi, Massimo Mangino, Melissa Liu, Michael R Brown, Matthew P Conomos, Min‐A Jhun, Ming‐Huei Chen, Moniek P.M. de Maat, Nathan Pankratz, Nicholas L Smith, Patricia A Peyser, Paul Elliot, Paul S de Vries, Peng Wei, Philipp S Wild, Pierre E Morange, Pim van der Harst, Qiong Yang, Ngoc‐Quynh Le, Riccardo Marioni, Ruifang Li, Scott M Damrauer, Simon R Cox, Stella Trompet, Stephan B Felix, Uwe Völker, Weihong Tang, Wolfgang Koenig, J. Wouter Jukema, Xiuqing Guo, Sara Lindstrom, Lu Wang, Erin N Smith, William Gordon, Astrid van Hylckama Vlieg, Mariza de Andrade, Jennifer A Brody, Jack W Pattee, Jeffrey Haessler, Ben M Brumpton, Daniel I Chasman, Pierre Suchon, Ming‐Huei Chen, Constance Turman, Marine Germain, Kerri L Wiggins, James MacDonald, Sigrid K Braekkan, Sebastian M Armasu, Nathan Pankratz, Rabecca D Jackson, Jonas B Nielsen, Franco Giulianini, Marja K Puurunen, Manal Ibrahim, Susan R Heckbert, Theo K Bammler, Kelly A Frazer, Bryan M McCauley, Kent Taylor, James S Pankow, Alexander P Reiner, Maiken E Gabrielsen, Jean‐François Deleuze, Chris J O’Donnell, Jihye Kim, Barbara McKnight, Peter Kraft, John‐Bjarne Hansen, Frits R Rosendaal, John A Heit, Bruce M Psaty, Weihong Tang, Charles Kooperberg, Kristian Hveem, Paul M Ridker, Pierre‐Emmanuel Morange, Andrew D Johnson, Christopher Kabrhel, David‐Alexandre Trégouët, Nicholas L Smith, Rainer Malik, Ganesh Chauhan, Matthew Traylor, Muralidharan Sargurupremraj, Yukinori Okada, Aniket Mishra, Loes Rutten‐Jacobs, Anne‐Katrin Giese, Sander W van der Laan, Solveig Gretarsdottir, Christopher D Anderson, Michael Chong, Hieab HH Adams, Tetsuro Ago, Peter Almgren, Philippe Amouyel, Hakan Ay, Traci M Bartz, Oscar R Benavente, Steve Bevan, Giorgio B Boncoraglio, Robert D Brown, Adam S Butterworth, Caty Carrera, Cara L Carty, Daniel I Chasman, Wei‐Min Chen, John W Cole, Adolfo Correa, Ioana Cotlarciuc, Carlos Cruchaga, John Danesh, Paul IW de Bakker, Anita L DeStefano, Marcel den Hoed, Qing Duan, Stefan T Engelter, Guido J Falcone, Rebecca F Gottesman, Raji P Grewal, Vilmundur Gudnason, Stefan Gustafsson, Jeffrey Haessler, Tamara B Harris, Ahamad Hassan, Aki S Havulinna, Susan R Heckbert, Elizabeth G Holliday, George Howard, Fang‐Chi Hsu, Hyacinth I Hyacinth, M Arfan Ikram, Erik Ingelsson, Marguerite R Irvin, Xueqiu Jian, Jordi Jiménez‐Conde, Julie A Johnson, J Wouter Jukema, Masahiro Kanai, Keith L Keene, Brett M Kissela, Dawn O Kleindorfer, Charles Kooperberg, Michiaki Kubo, Leslie A Lange, Carl D Langefeld, Claudia Langenberg, Lenore J Launer, Jin‐Moo Lee, Robin Lemmens, Didier Leys, Cathryn M Lewis, Wei‐Yu Lin, Arne G Lindgren, Erik Lorentzen, Patrik K Magnusson, Jane Maguire, Ani Manichaikul, Patrick F McArdle, James F Meschia, Braxton D Mitchell, Thomas H Mosley, Michael A Nalls, Toshiharu Ninomiya, Martin J O’Donnell, Bruce M Psaty, Sara L Pulit, Kristiina Rannikmäe, Alexander P Reiner, Kathryn M Rexrode, Kenneth Rice, Stephen S Rich, Paul M Ridker, Natalia S Rost, Peter M Rothwell, Jerome I Rotter, Tatjana Rundek, Ralph L Sacco, Saori Sakaue, Michele M Sale, Veikko Salomaa, Bishwa R Sapkota, Reinhold Schmidt, Carsten O Schmidt, Ulf Schminke, Pankaj Sharma, Agnieszka Slowik, Cathie LM Sudlow, Christian Tanislav, Turgut Tatlisumak, Kent D Taylor, Vincent NS Thijs, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Steffen Tiedt, Stella Trompet, Christophe Tzourio, Cornelia M van Duijn, Matthew Walters, Nicholas J Wareham, Sylvia Wassertheil‐Smoller, James G Wilson, Kerri L Wiggins, Qiong Yang, Salim Yusuf, Najaf Amin, Hugo S Aparicio, Donna K Arnett, John Attia, Alexa S Beiser, Claudine Berr, Julie E Buring, Mariana Bustamante, Valeria Caso, Yu‐Ching Cheng, Seung Hoan Choi, Ayesha Chowhan, Natalia Cullell, Jean‐François Dartigues, Hossein Delavaran, Pilar Delgado, Marcus Dörr, Gunnar Engström, Ian Ford, Wander S Gurpreet, Anders Hamsten, Laura Heitsch, Atsushi Hozawa, Laura Ibanez, Andreea Ilinca, Martin Ingelsson, Motoki Iwasaki, Rebecca D Jackson, Katarina Jood, Pekka Jousilahti, Sara Kaffashian, Lalit Kalra, Masahiro Kamouchi, Takanari Kitazono, Olafur Kjartansson, Manja Kloss, Peter J Koudstaal, Jerzy Krupinski, Daniel L Labovitz, Cathy C Laurie, Christopher R Levi, Linxin Li, Lars Lind, Cecilia M Lindgren, Vasileios Lioutas, Yong Mei Liu, Oscar L Lopez, Hirata Makoto, Nicolas Martinez‐Majander, Koichi Matsuda, Naoko Minegishi, Joan Montaner, Andrew P Morris, Elena Muiño, Martina Müller‐Nurasyid, Bo Norrving, Soichi Ogishima, Eugenio A Parati, Leema Reddy Peddareddygari, Nancy L Pedersen, Joanna Pera, Markus Perola, Alessandro Pezzini, Silvana Pileggi, Raquel Rabionet, Iolanda Riba‐Llena, Marta Ribasés, Jose R Romero, Jaume Roquer, Anthony G Rudd, Antti‐Pekka Sarin, Ralhan Sarju, Chloe Sarnowski, Makoto Sasaki, Claudia L Satizabal, Mamoru Satoh, Naveed Sattar, Norie Sawada, Gerli Sibolt, Ásgeir Sigurdsson, Albert Smith, Kenji Sobue, Carolina Soriano‐Tárraga, Tara Stanne, O Colin Stine, David J Stott, Konstantin Strauch, Takako Takai, Hideo Tanaka, Kozo Tanno, Alexander Teumer, Liisa Tomppo, Nuria P Torres‐Aguila, Emmanuel Touze, Shoichiro Tsugane, Andre G Uitterlinden, Einar M Valdimarsson, Sven J van der Lee, Henry Völzke, Kenji Wakai, David Weir, Stephen R Williams, Charles DA Wolfe, Quenna Wong, Huichun Xu, Taiki Yamaji, Dharambir K Sanghera, Olle Melander, Christina Jern, Daniel Strbian, Israel Fernandez‐Cadenas, W T Longstreth, Arndt Rolfs, Jun Hata, Daniel Woo, Jonathan Rosand, Guillaume Pare, Jemma C Hopewell, Danish Saleheen, Kari Stefansson, Bradford B Worrall, Steven J Kittner, Sudha Seshadri, Myriam Fornage, Hugh S Markus, Joanna MM Howson, Yoichiro Kamatani, Stephanie Debette, Martin Dichgans

    Journal of Thrombosis and Haemostasis　20　(6)　1331-1349　2022/06

    Publisher: Elsevier BV

    DOI： 10.1111/jth.15698 　

    ISSN： 1538-7836

  166. 24時間自由行動下血圧と家庭高血圧発症との関連性 大迫研究

    中山 晋吾, 佐藤 倫広, 目時 弘仁, 村上 任尚, 辰巳 友佳子, 浅山 敬, 原 梓, 廣瀬 卓男, 坪田 恵[宇津木], 菊谷 昌浩, 森 建文, 寳澤 篤, 今井 潤, 大久保 孝義

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　10回　96-96　2022/06

    Publisher: (NPO)日本高血圧学会

  167. Regular dental visits, periodontitis, tooth loss, and atherosclerosis: The Ohasama study. International-journal

    Sho Yamada, Takamasa Komiyama, Takashi Ohi, Takahisa Murakami, Yoshitada Miyoshi, Kosei Endo, Takako Hiratsuka, Azusa Hara, Michihiro Satoh, Yukako Tatsumi, Ryusuke Inoue, Kei Asayama, Masahiro Kikuya, Atsushi Hozawa, Hirohito Metoki, Yutaka Imai, Takayoshi Ohkubo, Yoshinori Hattori

    Journal of periodontal research　57　(3)　615-622　2022/06

    DOI： 10.1111/jre.12990 　

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    OBJECTIVE: We aimed to explore the association between regular dental visits and atherosclerosis and between periodontitis, number of remaining teeth, and atherosclerosis among community dwellers in Japan. BACKGROUND: Few studies have examined the association between regular dental visits, periodontitis, tooth loss, and atherosclerosis in community dwellers in Japan. METHODS: The participants of this cross-sectional study included community dwellers aged ≥55 years and residing in Ohasama. Exposure variables were regular dental visits; periodontitis, defined as radiographic alveolar bone loss (BL); the Centers for Disease Control/American Academy of Periodontology (CDC/AAP) classification; and number of remaining teeth. The primary outcome was atherosclerosis, defined as maximum carotid intima-media thickness ≥1.1 mm or confirmation of atheromatous plaque. RESULTS: Of 602 participants, 117 had atherosclerosis. In the multivariate model, compared to those with regular dental visits, the odds ratio (OR) (95% confidence intervals [CIs]) of atherosclerosis among those with the absence of regular dental visits was 2.16 (1.03-4.49). Regarding BL-max, compared with those in the first quartile, ORs (95% CIs) of those in the second, third, and fourth quartiles were 1.15 (0.65-2.30), 0.65 (0.32-1.35), and 1.57 (0.81-3.01), respectively. Regarding CDC/AAP classification, compared to those with no or mild periodontitis, ORs (95% CIs) for those with moderate and severe periodontitis were 2.48 (0.61-10.1) and 4.26 (1.01-17.5), respectively. Regarding the number of remaining teeth, compared to those with ≥20 teeth, ORs (95%CIs) for those with 10-19 and 1-9 teeth were 1.77 (1.004-3.12) and 0.96 (0.52-1.80), respectively. CONCLUSION: The absence of regular dental visits and presence of periodontitis are associated with atherosclerosis among community dwellers in Japan.

  168. Associations between the Combined Fat Mass Index and Fat-Free Mass Index with Carotid Intima-Media Thickness in a Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study.

    Masato Takase, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Kichiya Suzuki, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Journal of atherosclerosis and thrombosis　30　(3)　255-273　2022/05/26

    DOI： 10.5551/jat.63523 　

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    AIM: Although many epidemiological studies have shown that obesity assessed by body mass index is associated with carotid intima-media thickness (cIMT), few studies have evaluated fat-free mass, which is a component of body composition. We investigated the associations between the combined fat mass index (FMI) and fat-free mass index (FFMI) with cIMT. METHODS: We conducted a cross-sectional study of 3,873 men and 9,112 women aged 20 years or older who lived in Miyagi prefecture, Japan. The FMI and FFMI were calculated as fat mass and fat-free mass divided by height squared, respectively. The indices were classified into sex-specific quartiles and were combined into 16 groups. The maximum common carotid artery was measured using high-resolution B-mode ultrasound. An analysis of covariance was used to assess associations between the combined FMI and FFMI with cIMT adjusted for age and smoking status. The linear trend test was conducted by stratifying the FMI and FFMI, scoring the categories from 1 (lowest) to 4 (highest), and entering the number as a continuous term in the regression model. RESULTS: In multivariable models, a higher FMI was not related to higher cIMT in men and women in most FFMI subgroups. Conversely, a higher FFMI was related to higher cIMT in all FMI subgroups (p＜0.001 for linear trend). CONCLUSIONS: FMI was not associated with cIMT in most FFMI subgroups. Conversely, FFMI was positively associated with cIMT independently of FMI.

  169. A Pilot Study for Return of Individual Pharmacogenomic Results to Population-Based Cohort Study Participants.

    Kinuko Ohneda, Masahiro Hiratsuka, Hiroshi Kawame, Fuji Nagami, Yoichi Suzuki, Kichiya Suzuki, Akira Uruno, Mika Sakurai-Yageta, Yohei Hamanaka, Makiko Taira, Soichi Ogishima, Shinichi Kuriyama, Atsushi Hozawa, Hiroaki Tomita, Naoko Minegishi, Junichi Sugawara, Inaho Danjoh, Tomohiro Nakamura, Tomoko Kobayashi, Yumi Yamaguchi-Kabata, Shu Tadaka, Taku Obara, Eiji Hishimuma, Nariyasu Mano, Masaki Matsuura, Yuji Sato, Masateru Nakasone, Yohei Honkura, Jun Suzuki, Yukio Katori, Yoichi Kakuta, Atsushi Masamune, Yoko Aoki, Masaharu Nakayama, Shigeo Kure, Kengo Kinoshita, Nobuo Fuse, Masayuki Yamamoto

    JMA journal　5　(2)　177-189　2022/04/15

    DOI： 10.31662/jmaj.2021-0156 　

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    Introduction: Pharmacogenomic (PGx) testing results provide valuable information on drug selection and appropriate dosing, maximization of efficacy, and minimization of adverse effects. Although the number of large-scale, next-generation-sequencing-based PGx studies has recently increased, little is known about the risks and benefits of returning PGx results to ostensibly healthy individuals in research settings. Methods: Single-nucleotide variants of three actionable PGx genes, namely, MT-RNR1, CYP2C19, and NUDT15, were returned to 161 participants in a population-based Tohoku Medical Megabank project. Informed consent was obtained from the participants after a seminar on the outline of this study. The results were sent by mail alongside sealed information letter intended for clinicians. As an exception, genetic counseling was performed for the MT-RNR1 m.1555A > G variant carriers by a medical geneticist, and consultation with an otolaryngologist was encouraged. Questionnaire surveys (QSs) were conducted five times to evaluate the participants' understanding of the topic, psychological impact, and attitude toward the study. Results: Whereas the majority of participants were unfamiliar with the term PGx, and none had undergone PGx testing before the study, more than 80% of the participants felt that they could acquire basic PGx knowledge sufficient to understand their genomic results and were satisfied with their potential benefit and use in future prescriptions. On the other hand, some felt that the PGx concepts or terminology was difficult to fully understand and suggested that in-person return of the results was desirable. Conclusions: These results collectively suggest possible benefits of returning preemptive PGx information to ostensibly healthy cohort participants in a research setting.

  170. Trends in Prevalence, Treatment, and Control of Hypertension According to 40-Year-Old Life Expectancy at Prefectures in Japan from the National Health and Nutrition Surveys. International-journal

    Mizuki Sata, Tomonori Okamura, Nobuo Nishi, Aya Kadota, Mieko Nakamura, Keiko Kondo, Yukiko Okami, Kaori Kitaoka, Toshiyuki Ojima, Katsushi Yoshita, Katsuyuki Miura

    Nutrients　14　(6)　2022/03/14

    DOI： 10.3390/nu14061219 　

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    The prevalence of hypertension has been decreasing in Japan due to improved medical treatment and a decrease in dietary salt intake. However, disparities in the prevalence, treatment, and control of hypertension are expected to occur in different regions. This study aimed to investigate the trends in the prevalence, treatment, and control of hypertension at the prefectural level of life expectancy among Japanese population. We used data from the National Health and Nutrition Survey and analysed the individual survey information of individuals aged 40-69 years by dividing it into six terms, i.e., 1995-1997, 1999-2001, 2003-2005, 2007-2009, 2012, and 2016. Prefectures were classified into four groups according to their 40-year-old life expectancy in 2000. Outcome values were standardised to the population by 10-year age groups in 2010, and they were tested by two-way analysis of variance according to six terms and life expectancies. The prevalence of hypertension tended to decrease, especially among women, whereas the treatment and control tended to improve from the first to the sixth period in both men and women. The prevalence and treatment of hypertension in men with longer life expectancy tended to be lower than that in other groups, and there was no obvious difference in the control. In women, there were no obvious differences in the prevalence, treatment, or control. Reducing the prevalence of hypertension by improving lifestyle factors, such as high salt intake in each prefecture with a relatively short life expectancy, may be important to resolve the disparity in life expectancy among prefectures.

  171. Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan

    Nobuo Fuse, Miyuki Sakurai, Ikuko N. Motoike, Kaname Kojima, Takako Takai-Igarashi, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Akiko Miyazawa, Kei Homma, Keisuke Ido, Makiko Taira, Tomoko Kobayashi, Ritsuko Shimizu, Akira Uruno, Eiichi N. Kodama, Kichiya Suzuki, Yohei Hamanaka, Hiroaki Tomita, Junichi Sugawara, Yoichi Suzuki, Fuji Nagami, Soichi Ogishima, Fumiki Katsuoka, Naoko Minegishi, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Yaegashi, Shigeo Kure, Kengo Kinoshita, Masayuki Yamamoto

    Ophthalmology Science　2　(1)　100113-100113　2022/03

    Publisher: Elsevier BV

    DOI： 10.1016/j.xops.2022.100113 　

    ISSN： 2666-9145

  172. 東北メディカル・メガバンク計画健康調査における眼軸長のゲノムワイド関連解析

    布施 昇男, 櫻井 美由紀, 元池 育子, 小島 要, 平良 摩紀子, 宇留野 晃, 濱中 洋平, 中村 智洋, 荻島 創一, 寳澤 篤, 栗山 進一, 呉 繁夫, 木下 賢吾, 山本 雅之

    日本眼科学会雑誌　126　(臨増)　216-216　2022/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  173. Association between urinary sodium-to-potassium ratio and home blood pressure and ambulatory blood pressure: the Ohasama study. International-journal

    Tomoko Muroya, Michihiro Satoh, Takahisa Murakami, Shingo Nakayama, Kei Asayama, Takuo Hirose, Yukako Tatsumi, Ryusuke Inoue, Megumi Tsubota-Utsugi, Azusa Hara, Mana Kogure, Naoki Nakaya, Kyoko Nomura, Masahiro Kikuya, Hirohito Metoki, Yutaka Imai, Atsushi Hozawa, Takayoshi Ohkubo

    Journal of hypertension　40　(5)　862-869　2022/02/14

    DOI： 10.1097/HJH.0000000000003087 　

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    OBJECTIVE: No studies have demonstrated the association between urinary sodium-to-potassium (Na/K) ratio and all out-of-office blood pressure (BP) [home morning and evening BP (self-measured at home), and 24-h, daytime, and night-time ambulatory BP] in the same cohort. We aimed to assess, which type of out-of-office BP is more strongly associated with urinary Na/K ratio in the general population. METHODS: This cross-sectional study was conducted in the general population of Ohasama, Japan. Home and ambulatory BP levels were measured, and 24-h urine samples were obtained from 875 participants (men, 25.5%; mean age, 60.1 years). The urinary Na/K ratio in the 24-h urine samples was calculated. RESULTS: The median (interquartile range) urinary Na/K ratio was 4.19 (3.36-5.26). Significant positive trends of home morning, home evening, 24-h, and daytime SBP were observed across quartiles of urinary Na/K ratio (trend P ≤ 0.041; adjusted mean values between Q1 and Q4 of urinary Na/K ratio: 121.0-125.5 mmHg for home morning, 120.1-123.8 mmHg for home evening, 121.6-123.4 mmHg for 24-h, 127.5-129.5 mmHg for daytime). Urinary Na/K ratio was not significantly associated with office or night-time SBP and nocturnal BP fall (trend P ≥ 0.13). In the model with both home morning or evening SBP and daytime SBP, only home SBP was significantly associated with urinary Na/K ratio (P ≤ 0.048 for home SBP). CONCLUSION: These findings suggest that urinary Na/K ratio might be more strongly associated with home BP than with 24-h and daytime BP but was not associated with night-time BP.

  174. Public Access to Summary Statistics for Genome-wide Association Studies of Body Mass Index, Weight, and Height Among Healthy Japanese Individuals: The Japanese Consortium of Genetic Epidemiology Studies.

    Atsushi Goto, Shiori Suzuki, Ryoko Katagiri, Taiki Yamaji, Norie Sawada, Masahiro Nakatochi, Kenji Wakai, Atsushi Hozawa, Kengo Kinoshita, Kozo Tanno, Atsushi Shimizu, Hidemi Ito, Keitaro Matsuo, Motoki Iwasaki

    Journal of epidemiology　32　(2)　115-116　2022/02/05

    DOI： 10.2188/jea.JE20210459 　

  175. Consideration of the reference value and number of measurements of the urinary sodium-to-potassium ratio based on the prevalence of untreated home hypertension: TMM Cohort Study. International-journal

    Mana Kogure, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Kotaro Nochioka, Akira Narita, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Taku Obara, Michihiro Satoh, Hirohito Metoki, Ken Miyagawa, Hiroshi Koshimizu, Sho Nagayoshi, Akira Uruno, Masahiro Kikuya, Kichiya Suzuki, Naoki Nakaya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension　45　(5)　866-875　2022/01/18

    DOI： 10.1038/s41440-021-00843-7 　

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    The sodium-to-potassium (Na/K) ratio is known to be associated with blood pressure (BP). However, no reference value has been established since the urinary Na/K (uNa/K) ratio is known to have diurnal and day-to-day variations. Therefore, we investigated the number of days required to yield a better association between the morning uNa/K ratio and home BP (HBP) and determined a morning uNa/K ratio value that can be used as a reference value in participants who are not taking antihypertensive medication. This was a cross-sectional study using data from the Tohoku Medical Megabank Project Cohort Study. A total of 3122 participants borrowed HBP and uNa/K ratio monitors for 10 consecutive days. We assessed the relationship between the morning uNa/K ratio from 1 day to 10 days and home hypertension (HBP ≥ 135/85 mmHg) using multiple logistic regression models. Although a 1-day measurement of the morning uNa/K ratio was positively associated with home hypertension, multiple measurements of the morning uNa/K ratio were strongly related to home hypertension. The average morning uNa/K ratio was relatively stable after 3 days (adjusted odds ratio of home hypertension per unit increase in the uNa/K ratio for more than 3 days: 1.19-1.23). In conclusion, there was no threshold for the uNa/K ratio, and the morning uNa/K ratio was linearly associated with home hypertension. The Na/K ratio 2.0 calculated from the Dietary Reference Intakes for Japanese might be a good indication. Regarding the stability of the association between the morning uNa/K ratio and BP, more than 3 days of measurements is desirable.

  176. White blood cell count profile in patients with physical complaints without known causes. International-journal

    Tetsuya Akaishi, Tadashi Ishii, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Masashi Aoki, Atsushi Hozawa

    SAGE open medicine　10　20503121221105328-20503121221105328　2022

    DOI： 10.1177/20503121221105328 　

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    OBJECTIVES: The aim of this study was to search for routine blood test biomarkers in patients with physical symptoms but without a diagnosis after comprehensive routine screening diagnostic examinations. METHODS: A total of 228 adults aged < 65 years who presented with physical complaints without known causes after comprehensive screening diagnostic examinations and 228 age- and sex-matched healthy controls without physical complaints were enrolled. The blood cell count data at the first hospital visit were compared between these groups. RESULTS: Total white blood cell (p = 0.2143), red blood cell (p = 0.8954), and platelet (p = 0.7716) counts did not differ between the groups. The monocyte count (p = 0.0014) and resultant monocyte-to-lymphocyte ratio (p < 0.0001) were higher in the symptomatic group, while the other white blood cell subtypes did not differ significantly between the two groups. In the symptomatic group, patients with a monocyte-to-lymphocyte ratio > 0.25 were likely to have unexplained nonfocal physical symptoms (p < 0.0001). The characteristic findings included fatigability (p < 0.0001), prolonged slight fever (p = 0.0005), and widespread pain (p < 0.0001). The monocyte-to-lymphocyte ratio level was correlated with the proportion of patients with unexplained nonfocal symptoms. CONCLUSION: The blood cell count profile was largely the same between healthy individuals and patients with unexplained physical symptoms. However, patients with unexplained nonfocal physical complaints were likely to show an elevated monocyte-to-lymphocyte ratio, typically > 0.25.

  177. 東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の進捗

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 菅野 郁美, 小原 拓, 中村 智洋, 宇留野 晃, 布施 昇男, 泉 陽子, 丹野 高三, 辻 一郎, 栗山 進一, 呉 繁夫, 寳澤 篤

    Journal of Epidemiology　32　(Suppl.1)　162-162　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  178. 地域および職域の健康診査に尿Na/K比測定を導入して見えてきたこと 健診機関とのタイアップ

    小暮 真奈, 佐々木 久美子, 畑中 里衣子, 菅野 郁美, 板橋 芙美, 黒川 悦子, 大川 亜美, 宮川 健, 永吉 翔, 牛田 悠介, 清水 友紀子, 上田 宏幸, 土屋 菜歩, 中谷 直樹, 寳澤 篤

    総合健診　49　(1)　205-205　2022/01

    Publisher: (一社)日本総合健診医学会

    ISSN： 1347-0086

    eISSN： 1884-4103

  179. 脂肪量指数および除脂肪量指数の組み合わせと頸動脈内膜中膜複合体厚(IMT)の肥厚との関連

    高瀬 雅仁, 中村 智洋, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 菅野 郁美, 土屋 菜歩, 平田 匠, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    Journal of Epidemiology　32　(Suppl.1)　126-126　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  180. 脂肪量指数および除脂肪量指数の組み合わせと頸動脈内膜中膜複合体厚(IMT)の肥厚との関連

    高瀬 雅仁, 中村 智洋, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 菅野 郁美, 土屋 菜歩, 平田 匠, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    Journal of Epidemiology　32　(Suppl.1)　126-126　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  181. 地域および職域の健康診査に尿Na/K比測定を導入して見えてきたこと 健診機関とのタイアップ

    小暮 真奈, 佐々木 久美子, 畑中 里衣子, 菅野 郁美, 板橋 芙美, 黒川 悦子, 大川 亜美, 宮川 健, 永吉 翔, 牛田 悠介, 清水 友紀子, 上田 宏幸, 土屋 菜歩, 中谷 直樹, 寳澤 篤

    総合健診　49　(1)　205-205　2022/01

    Publisher: (一社)日本総合健診医学会

    ISSN： 1347-0086

    eISSN： 1884-4103

  182. Regional brain development in fetuses with Dandy-Walker malformation: A volumetric fetal brain magnetic resonance imaging study. International-journal

    Shizuko Akiyama, Neel Madan, George Graham, Osamu Samura, Rie Kitano, Hyuk Jin Yun, Alexa Craig, Tomohiro Nakamura, Atsushi Hozawa, Ellen Grant, Kiho Im, Tomo Tarui

    PloS one　17　(2)　e0263535　2022

    DOI： 10.1371/journal.pone.0263535 　

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    Dandy-Walker malformation (DWM) is a common prenatally diagnosed cerebellar malformation, characterized by cystic dilatation of the fourth ventricle, upward rotation of the hypoplastic vermis, and posterior fossa enlargement with torcular elevation. DWM is associated with a broad spectrum of neurodevelopmental abnormalities such as cognitive, motor, and behavioral impairments, which cannot be explained solely by cerebellar malformations. Notably, the pathogenesis of these symptoms remains poorly understood. This study investigated whether fetal structural developmental abnormalities in DWM extended beyond the posterior fossa to the cerebrum even in fetuses without apparent cerebral anomalies. Post-acquisition volumetric fetal magnetic resonance imaging (MRI) analysis was performed in 12 fetuses with DWM and 14 control fetuses. Growth trajectories of the volumes of the cortical plate, subcortical parenchyma, cerebellar hemispheres, and vermis between 18 and 33 weeks of gestation were compared. The median (interquartile range) gestational ages at the time of MRI were 22.4 (19.4-24.0) and 23.9 (20.6-29.2) weeks in the DWM and control groups, respectively (p = 0.269). Eight of the 12 fetuses with DWM presented with associated cerebral anomalies, including hydrocephalus (n = 3), cerebral ventriculomegaly (n = 3), and complete (n = 2) and partial (n = 2) agenesis of the corpus callosum (ACC); 7 presented with extracerebral abnormalities. Chromosomal abnormalities were detected by microarray analysis in 4 of 11 fetuses with DWM, using amniocentesis. Volumetric analysis revealed that the cortical plate was significantly larger in fetuses with DWM than in controls (p = 0.040). Even without ACC, the subcortical parenchyma, whole cerebrum, cerebellar hemispheres, and whole brain were significantly larger in fetuses with DWM (n = 8) than in controls (p = 0.004, 0.025, 0.033, and 0.026, respectively). In conclusion, volumetric fetal MRI analysis demonstrated that the development of DWM extends throughout the brain during the fetal period, even without apparent cerebral anomalies.

  183. dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project. International-journal

    Soichi Ogishima, Satoshi Nagaie, Satoshi Mizuno, Ryosuke Ishiwata, Keita Iida, Kazuro Shimokawa, Takako Takai-Igarashi, Naoki Nakamura, Sachiko Nagase, Tomohiro Nakamura, Naho Tsuchiya, Naoki Nakaya, Keiko Murakami, Fumihiko Ueno, Tomomi Onuma, Mami Ishikuro, Taku Obara, Shunji Mugikura, Hiroaki Tomita, Akira Uruno, Tomoko Kobayashi, Akito Tsuboi, Shu Tadaka, Fumiki Katsuoka, Akira Narita, Mika Sakurai, Satoshi Makino, Gen Tamiya, Yuichi Aoki, Ritsuko Shimizu, Ikuko N Motoike, Seizo Koshiba, Naoko Minegishi, Kazuki Kumada, Takahiro Nobukuni, Kichiya Suzuki, Inaho Danjoh, Fuji Nagami, Kozo Tanno, Hideki Ohmomo, Koichi Asahi, Atsushi Shimizu, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Fuse, Teiji Tominaga, Shigeo Kure, Nobuo Yaegashi, Kengo Kinoshita, Makoto Sasaki, Hiroshi Tanaka, Masayuki Yamamoto

    Human genome variation　8　(1)　44-44　2021/12/10

    DOI： 10.1038/s41439-021-00175-5 　

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    To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an integrated biobank, we developed an integrated database called "dbTMM" that incorporates both the individual cohort/clinical data and the genome/multiomics data of 157,191 participants in the Tohoku Medical Megabank project. To our knowledge, dbTMM is the first database to store individual whole-genome data on a variant-by-variant basis as well as cohort/clinical data for over one hundred thousand participants in a prospective cohort study. dbTMM enables us to stratify our cohort by both genome-wide genetic factors and environmental factors, and it provides a research and development platform that enables prospective analysis of large-scale data from genome cohorts.

  184. Association between fat mass index, fat-free mass index and hemoglobin A1c in a Japanese population: The Tohoku Medical Megabank Community-based Cohort Study.

    Masato Takase, Tomohiro Nakamura, Takumi Hirata, Naho Tsuchiya, Mana Kogure, Fumi Itabashi, Naoki Nakaya, Yohei Hamanaka, Junichi Sugawara, Kichiya Suzuki, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Journal of diabetes investigation　13　(5)　858-867　2021/12/03

    DOI： 10.1111/jdi.13729 　

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    AIMS/INTRODUCTION: Fat mass and fat-free mass affect glycated hemoglobin A1c (HbA1c) levels and blood glucose levels, respectively. The aim of the present study was to examine the association between the fat mass index and fat-free mass index with HbA1c. MATERIALS AND METHODS: We carried out a cross-sectional study that included 3,731 men and 9,191 women aged ≥20 years, living in Miyagi Prefecture, Japan, who were not treated for diabetes. The fat mass index and fat-free mass index were calculated as fat mass and fat-free mass divided by the height squared, respectively. The indices were classified into sex-specific quartiles and combined into 16 groups. An analysis of covariance was used to assess associations between the combined fat mass index and fat-free mass index with HbA1c adjusted for potential confounders. The linear trend test was carried out by stratifying the fat mass index and fat-free mass index, entering the number as a continuous term in the regression model. RESULTS: In multivariable models, a higher fat mass index was related to higher HbA1c levels in men and women in all fat-free mass index subgroups (P < 0.001 for linear trend). When we excluded the participants who had been identified as having diabetes, the fat-free mass index was also related to higher HbA1c levels in most fat mass index subgroups (P < 0.05 for linear trend). CONCLUSIONS: Fat mass index was positively related to HbA1c levels. The fat-free mass index was also related to HbA1c levels when we excluded participants who had been identified as having have diabetes.

  185. The prevalence of current smokers and alcohol drinkers among cancer survivors and subjects with no history of cancer among participants in a community-based cardiometabolic screening program in Miyagi prefecture, Japan: a comparison with nationally representative surveys in other countries. International-journal

    Yuka Nishimoto, Yoshitaka Tsubono, Mana Kogure, Tomohiro Nakamura, Fumi Itabashi, Naho Tsuchiya, Naoki Nakaya, Kozo Tanno, Junichi Sugawara, Shinichi Kuriyama, Shigeo Kure, Ichiro Tsuji, Atsushi Hozawa

    Cancer medicine　10　(24)　9000-9011　2021/12

    DOI： 10.1002/cam4.4364 　

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    BACKGROUND: We determined the prevalence of current cigarette smokers and alcohol drinkers among cancer survivors and subjects with no history of cancer in Japan and compared the findings with nationally representative studies in other countries. METHODS: We conducted a cross-sectional study of baseline data from a prospective cohort study. A self-administered questionnaire was surveyed during 2013-2015 with residents aged ≥20 years attending a community-based cardiometabolic screening program in Miyagi prefecture in north-eastern Japan. Subjects with past cancer histories were classified as cancer survivors. Sex-specific, age-standardized prevalence of current smokers, and drinkers were calculated. Age-adjusted prevalence ratios (PRs: the cancer survivors' rate divided by the rate of subjects with no history of cancer) and 95% confidence intervals (CIs) were estimated with log-binomial regressions. RESULTS: 36,786 subjects, including 2760 cancer survivors, responded and provided usable information (58.9% of recruited subjects). For men, the age-standardized prevalence of current smokers and drinkers among survivors was 18.8% and 74.4%, respectively, with an age-adjusted PR (95%CI) of 0.76 (0.66-0.86, p < 0.001) and 0.95 (0.91-0.98, p = 0.002), respectively. For women, the figures were 6.1%, 37.9%, 0.84 (0.67-1.06, p = 0.138) and 0.96 (0.90-1.03, p = 0.313), respectively. The U.S., the U.K, and Australian studies generally showed no substantially lower prevalence of current smokers or drinkers in survivors than in subjects with no history of cancer (PR ≥ 0.75), while Korean studies did (PR < 0.75). CONCLUSIONS: A considerable proportion of Japanese cancer survivors, especially men, remained currently smoking and drinking. Consistent with Western studies, the rates were not substantially lower than those among subjects with no history of cancer.

  186. Association between the social isolation and depressive symptoms after the great East Japan earthquake: findings from the baseline survey of the TMM CommCohort study International-journal

    Yuka Kotozaki, Kozo Tanno, Kiyomi Sakata, Eri Takusari, Kotaro Otsuka, Hiroaki Tomita, Ryohei Sasaki, Nobuyuki Takanashi, Takahiro Mikami, Atsushi Hozawa, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Yasuyuki Taki, Atsushi Shimizu, Jiro Hitomi, Mamoru Satoh, Makoto Sasaki

    BMC Public Health　21　(1)　925-925　2021/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s12889-021-10896-5 　

    eISSN： 1471-2458

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    <title>Abstract</title><sec> <title>Background</title> Social isolation and mental health issues have become a severe problem in disaster areas in the Great East Japan Earthquake. This study examined whether the combination of the house damage and social isolation or the combination of the death of family members and social isolation is associated with depressive symptoms among survivors using the baseline study data of the Tohoku Medical Megabank Project Community-Based Cohort Study (TMM CommCohort Study). </sec><sec> <title>Methods</title> We used cross-sectional data from a baseline survey of 48,958 participants (18,423 males, 30,535 females; aged 60.1 ± 11.2 years) to examine the association between social isolation measured by the Lubben social network scale 6 (LSNS-6) and depressive symptoms measured by the Center for Epidemiological Studies-Depressive Scale (CES-D). The presence of social isolation and depressive symptoms was defined by an LSNS-6 score of &lt; 12 and a CES-D score of ≥16, respectively. We performed a logistic regression analysis to determine the multivariable-adjusted odds ratio (95% confidence interval) [AOR (95% CI)] for depressive symptoms according to sex in the social isolation in comparison to without social isolation, and the associations of the combination of the house damage or the death of family members and social isolation and depressive symptoms. </sec><sec> <title>Results</title> Social isolation was significantly associated with depressive symptoms (males: OR = 1.87; 95% CI = 1.72–2.04, females: OR = 2.13; 95% CI = 2.00–2.26). Both males and females respondents with severe house damage and social isolation had a greater risk of depressive symptoms in comparison to those with an undamaged house and without social isolation (males: OR = 3.40; 95% CI = 2.73–4.24, females: OR = 2.92; 95% CI = 2.46–3.46). The risk of depressive symptoms was also higher in both males and females respondents with the death of family members and social isolation in comparison to those without the death of family members and without social isolation (males: OR = 2.18; 95% CI = 1.90–2.50, females: OR = 2.60; 95% CI = 2.35–2.88). </sec><sec> <title>Conclusion</title> The findings suggested that a combination of social isolation and severe house damage and the death of family members caused by a large-scale natural disaster was associated with a higher risk of depressive symptoms although the interaction was not statistically significant. </sec>

  187. White blood cell count profiles in multiple sclerosis during attacks before the initiation of acute and chronic treatments. International-journal

    Tetsuya Akaishi, Tatsuro Misu, Kazuo Fujihara, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Toshiyuki Takahashi, Hiroshi Kuroda, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima, Atsushi Hozawa

    Scientific reports　11　(1)　22357-22357　2021/11/16

    DOI： 10.1038/s41598-021-01942-8 　

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    Multiple sclerosis (MS) is a major demyelinating disease of the central nervous system; however, its exact mechanism is unknown. This study aimed to elucidate the profile of white blood cells (WBCs) in the acute phase of an MS attack. Sixty-four patients with MS at the time of diagnosis and 2492 age- and sex-adjusted healthy controls (HCs) were enrolled. Data regarding the blood cell counts were compared between the groups. The total WBC (p < 0.0001), monocyte (p < 0.0001), basophil (p = 0.0027), and neutrophil (p < 0.0001) counts were higher in the MS group than in the HC group, whereas the lymphocyte and eosinophil counts did not differ. Adjustments for the smoking status and body mass index yielded the same results. The total and differential WBC counts of the patients with MS did not correlate with the counts of T2 hyperintense brain lesions or the levels of neurological disturbance. In summary, patients with MS showed elevated counts of total WBCs, monocytes, basophils, and neutrophils at the time of diagnosis. However, the clinical relevance of these biomarkers in the context of the development and progression of MS remains unclear.

  188. Prediction models for the 5- and 10-year incidence of home morning hypertension: The Ohasama Study. International-journal

    Michihiro Satoh, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Takahisa Murakami, Yukako Tatsumi, Azusa Hara, Megumi Tsubota-Utsugi, Takuo Hirose, Ryusuke Inoue, Kyoko Nomura, Atsushi Hozawa, Yutaka Imai, Takayoshi Ohkubo

    American journal of hypertension　35　(4)　328-336　2021/11/16

    DOI： 10.1093/ajh/hpab177 　

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    BACKGROUND: We aimed to develop risk prediction models for new-onset home morning hypertension. METHODS: We followed up 978 participants without home hypertension in the general population of Ohasama, Japan (men: 30.1%, age: 53.3 years). The participants were divided into derivation (n=489) and validation (n=489) cohorts by their residential area. The C-statistics and calibration plots were assessed after the 5- or 10-year follow-up. RESULTS: In the derivation cohort, sex, age, body mass index, smoking, office systolic blood pressure (SBP), and home SBP at baseline were selected as significant risk factors for new-onset home hypertension (≥135/85 mmHg or the initiation of antihypertensive treatment) using the Cox model. In the validation cohort, Harrell's C-statistic for the 5-year/ 10-year home hypertension was 0.7637 (0.7195-0.8100)/ 0.7308 (0.6932-0.7677), when we used the full model, which included the significant risk factors in the derivation cohort. The calibration test revealed good concordance between the observed and predicted 5-years/ 10-year home hypertension probabilities (P≥0.19); the regression slope of the observed probability on the predicted probability was 1.10/1.02, and the intercept was -0.04/0.06, respectively. A model without home SBP was also developed; for the 10-year home hypertension risk, the calibration test revealed a good concordance (P=0.19) but Harrell's C-statistic was 0.6689 (0.6266-0.7067). CONCLUSIONS: The full model revealed good ability to predict the 5-year and 10-year home morning hypertension risk. Although the model without home SBP is acceptable, the low C-statistic implies that home BP should be measured to predict home morning hypertension precisely.

  189. Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator. International-journal

    Mitsuhiro Yamada, Ikuko N Motoike, Kaname Kojima, Nobuo Fuse, Atsushi Hozawa, Shinichi Kuriyama, Fumiki Katsuoka, Shu Tadaka, Matsuyuki Shirota, Miyuki Sakurai, Tomohiro Nakamura, Yohei Hamanaka, Kichiya Suzuki, Junichi Sugawara, Soichi Ogishima, Akira Uruno, Eiichi N Kodama, Naoya Fujino, Tadahisa Numakura, Tomohiro Ichikawa, Ayumi Mitsune, Takashi Ohe, Kengo Kinoshita, Masakazu Ichinose, Hisatoshi Sugiura, Masayuki Yamamoto

    Communications biology　4　(1)　1288-1288　2021/11/15

    DOI： 10.1038/s42003-021-02813-8 　

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    Lung function reflects the ability of the respiratory system and is utilized for the assessment of respiratory diseases. Because type 2 airway inflammation influences lung function, genome wide association studies (GWAS) for lung function would be improved by adjustment with an indicator of the inflammation. Here, we performed a GWAS for lung function with adjustment for exhaled nitric oxide (FeNO) levels in two independent Japanese populations. Our GWAS with genotype imputations revealed that the RNF5/AGER locus including AGER rs2070600 SNP, which introduces a G82S substitution of AGER, was the most significantly associated with FEV1/FVC. Three other rare missense variants of AGER were further identified. We also found genetic loci with three candidate genes (NOS2, SPSB2 and RIPOR2) associated with FeNO levels. Analyses with the BioBank-Japan GWAS resource revealed genetic links of FeNO and asthma-related traits, and existence of common genetic background for allergic diseases and their biomarkers. Our study identified the genetic locus most strongly associated with airway obstruction in the Japanese population and three genetic loci associated with FeNO, an indicator of type 2 airway inflammation in adults.

  190. Impact of type of reconstructed residence on social participation and mental health of population displaced by disasters. International-journal

    Tomomi Suzuki, Tetsuya Akaishi, Harumi Nemoto, Yusuke Utsumi, Moe Seto, Hitomi Usukura, Yasuto Kunii, Yumi Sugawara, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Atsushi Hozawa, Ichiro Tsuji, Tadashi Ishii, Hiroaki Tomita

    Scientific reports　11　(1)　21465-21465　2021/11/02

    DOI： 10.1038/s41598-021-00913-3 　

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    After disasters, people are often forced to reconstruct or move to new residences. This study aimed to reveal the association between the types of reconstructed residences and psychosocial or psychiatric conditions among the population. A total of 1071 adult residents in a coastal town, whose houses were destroyed by the tsunami caused by the Great East Japan Earthquake, enrolled in the study five years after the disaster. The type of reconstructed post-disaster residences (reconstructed on the same site/disaster-recovery public condominium/mass-translocation to higher ground/privately moving to remote areas) and the current psychosocial indicators were investigated. The results revealed that individuals living in public condominiums showed significantly worse scores on the Lubben Social Network Scale-6 (p < 0.0001) and the Center for Epidemiologic Studies Depression Scale (p < 0.0001), and slightly worse scores on the Kessler Psychological Distress Scale (p = 0.035) and the Impact of Event Scale-Revised (p = 0.028). Lower psychosocial indicator scores in the public condominium group were more remarkable in younger adults aged < 65 years. Insomnia evaluated using the Athens Insomnia Scale was not different among the four residential types. In summary, residents moving into disaster-recovery public condominiums are likely to have less social interaction, be more depressed, and may need additional interventions.

  191. 出産回数と認知機能との関連に関する横断研究 大迫研究

    山崎 貞一郎, 野村 恭子, 佐藤 倫広, 原 梓, 坪田 恵, 村上 任尚, 広瀬 卓男, 辰巳 友佳子, 浅山 敬, 菊谷 昌浩, 目時 弘仁, 寳澤 篤, 大久保 孝義

    日本公衆衛生学会総会抄録集　80回　405-405　2021/11

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  192. 東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の概要

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 菅野 郁美, 中谷 久美, 小原 拓, 中村 智洋, 宇留野 晃, 布施 昇男, 泉 陽子, 丹野 高三, 辻 一郎, 栗山 進一, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　80回　219-219　2021/11

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  193. 出産回数と認知機能との関連に関する横断研究 大迫研究

    山崎 貞一郎, 野村 恭子, 佐藤 倫広, 原 梓, 坪田 恵, 村上 任尚, 広瀬 卓男, 辰巳 友佳子, 浅山 敬, 菊谷 昌浩, 目時 弘仁, 寳澤 篤, 大久保 孝義

    日本公衆衛生学会総会抄録集　80回　405-405　2021/11

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  194. Association between the combined fat mass and fat-free mass index and hypertension: The Tohoku Medical Megabank Community-based Cohort Study. International-journal

    Masato Takase, Tomohiro Nakamura, Naho Tsuchiya, Mana Kogure, Fumi Itabashi, Akira Narita, Takumi Hirata, Naoki Nakaya, Yohei Hamanaka, Junichi Sugawara, Kichiya Suzuki, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Clinical and experimental hypertension (New York, N.Y. : 1993)　43　(7)　610-621　2021/10/03

    DOI： 10.1080/10641963.2021.1925681 　

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    BACKGROUND: A  higher body fat percentage is associated with hypertension, even in non-obese individuals. The difference in body composition may be related to hypertension. The fat mass index (FMI) and fat-free mass index (FFMI) are proposed indicators of body composition. This study aimed to examine the relationship of a combination of FMI and FFMI with hypertension. METHODS: We conducted a cross-sectional study of 5,058 men and 11,842 women aged ≥ 20 years in the Miyagi Prefecture, northeastern Japan. The FMI and FFMI were calculated as the fat mass and fat-free mass divided by the height squared, respectively. The indices were classified into quartiles and combined into 16 groups. Hypertension was defined as casual blood pressure ≥ 140/90 mmHg and/or self-reported treatment for hypertension. Multivariable logistic regression models, adjusted for potential confounders, were used to assess the relationship of a combination of FMI and FFMI with hypertension. RESULTS: Higher FMI was associated with hypertension in most of the FFMI subgroups. Similarly, a higher FFMI was associated with hypertension in most of FMI subgroups. For men, the association between FFMI and hypertension in the lowest FMI group was not significant. CONCLUSIONS: Reducing the FMI and FFMI may be important in preventing hypertension. For men, the relationship between the FFMI and hypertension in the lowest FMI group might be weak.

  195. 家庭血圧に基づく高血圧発症10年予測モデル 大迫研究

    佐藤 倫広, 目時 弘仁, 浅山 敬, 菊谷 昌浩, 村上 任尚, 辰巳 友佳子, 原 梓, 廣瀬 卓男, 井上 隆輔, 野村 恭子, 寳澤 篤, 今井 潤, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集　43回　318-318　2021/10

    Publisher: (NPO)日本高血圧学会

  196. 家庭血圧に基づく高血圧発症10年予測モデル 大迫研究

    佐藤 倫広, 目時 弘仁, 浅山 敬, 菊谷 昌浩, 村上 任尚, 辰巳 友佳子, 原 梓, 廣瀬 卓男, 井上 隆輔, 野村 恭子, 寳澤 篤, 今井 潤, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集　43回　318-318　2021/10

    Publisher: (NPO)日本高血圧学会

  197. Spousal similarities in cardiometabolic risk factors: A cross-sectional comparison between Dutch and Japanese data from two large biobank studies. International-journal

    Naoki Nakaya, Tian Xie, Bart Scheerder, Naho Tsuchiya, Akira Narita, Tomohiro Nakamura, Hirohito Metoki, Taku Obara, Mami Ishikuro, Atsushi Hozawa, Harold Snieder, Shinichi Kuriyama

    Atherosclerosis　334　85-92　2021/10

    DOI： 10.1016/j.atherosclerosis.2021.08.037 　

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    BACKGROUND AND AIMS: Few studies have examined and compared spousal concordance in different populations. This study aimed to quantify and compare spousal similarities in cardiometabolic risk factors and diseases between Dutch and Japanese populations. METHODS: This cross-sectional study included 28,265 Dutch Lifelines Cohort Study spouse pairs (2006-2013) and 5,391 Japanese Tohoku Medical Megabank Organization (ToMMo) Cohort Study pairs (2013-2016). Spousal similarities in cardiometabolic risk factors were evaluated using Pearson's correlation or logistic regression analyses adjusted for spousal age. RESULTS: The husbands' and wives' average ages in the Lifelines and ToMMo cohorts were 50.0 and 47.7 years and 63.2 and 60.4 years, respectively. Significant spousal similarities occurred with all cardiometabolic risk factors and diseases of interest in both cohorts. The age-adjusted correlation coefficients ranged from 0.032 to 0.263, with the strongest correlations observed in anthropometric traits. Spousal odds ratios [95% confidence interval] for the Lifelines vs. ToMMo cohort ranged from 1.45 (1.36-1.55) vs. 1.20 (1.05-1.38) for hypertension to 6.86 (6.30-7.48) vs. 4.60 (3.52-6.02) for current smoking. An increasing trend in spousal concordance with age was observed for sufficient physical activity in both cohorts. For current smoking, those aged 20-39 years showed the strongest concordance between pairs in both cohorts. The Dutch pairs showed stronger similarities in anthropometric traits and lifestyle habits (smoking and drinking) than their Japanese counterparts. CONCLUSIONS: Spouses showed similarities in several cardiometabolic risk factors among Dutch and Japanese populations, with regional and cultural influences on spousal similarities.

  198. Comparison of Kit-Based Metabolomics with Other Methodologies in a Large Cohort, towards Establishing Reference Values International-journal

    Daisuke Saigusa, Eiji Hishinuma, Naomi Matsukawa, Masatomo Takahashi, Jin Inoue, Shu Tadaka, Ikuko N. Motoike, Atsushi Hozawa, Yoshihiro Izumi, Takeshi Bamba, Kengo Kinoshita, Kim Ekroos, Seizo Koshiba, Masayuki Yamamoto

    Metabolites　11　(10)　652-652　2021/09/24

    Publisher: MDPI AG

    DOI： 10.3390/metabo11100652 　

    eISSN： 2218-1989

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    Metabolic profiling is an omics approach that can be used to observe phenotypic changes, making it particularly attractive for biomarker discovery. Although several candidate metabolites biomarkers for disease expression have been identified in recent clinical studies, the reference values of healthy subjects have not been established. In particular, the accuracy of concentrations measured by mass spectrometry (MS) is unclear. Therefore, comprehensive metabolic profiling in large-scale cohorts by MS to create a database with reference ranges is essential for evaluating the quality of the discovered biomarkers. In this study, we tested 8700 plasma samples by commercial kit-based metabolomics and separated them into two groups of 6159 and 2541 analyses based on the different ultra-high-performance tandem mass spectrometry (UHPLC-MS/MS) systems. We evaluated the quality of the quantified values of the detected metabolites from the reference materials in the group of 2541 compared with the quantified values from other platforms, such as nuclear magnetic resonance (NMR), supercritical fluid chromatography tandem mass spectrometry (SFC-MS/MS) and UHPLC-Fourier transform mass spectrometry (FTMS). The values of the amino acids were highly correlated with the NMR results, and lipid species such as phosphatidylcholines and ceramides showed good correlation, while the values of triglycerides and cholesterol esters correlated less to the lipidomics analyses performed using SFC-MS/MS and UHPLC-FTMS. The evaluation of the quantified values by MS-based techniques is essential for metabolic profiling in a large-scale cohort.

  199. The association of disproportionately enlarged subarachnoid space hydrocephalus with cognitive deficit in a general population: the Ohasama study. International-journal

    Tomofumi Nishikawa, Ichiro Akiguchi, Michihiro Satoh, Azusa Hara, Mikio Hirano, Aya Hosokawa, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Kyoko Nomura, Atsushi Hozawa, Naomi Miyamatsu, Yutaka Imai, Takayoshi Ohkubo

    Scientific reports　11　(1)　17061-17061　2021/08/23

    DOI： 10.1038/s41598-021-95961-0 　

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    Disproportionately enlarged subarachnoid space hydrocephalus (DESH) is the characteristic feature of idiopathic normal pressure hydrocephalus. We aimed to characterize the prevalence, development, and association of DESH to cognitive deficit in a large population. We reviewed the data of 1384 subjects eligible for the present study among 1590 participants who underwent magnetic resonance imaging (MRI) in the Ohasama Study, a population-based study in Ohasama, Japan. The participants with Mini-Mental State Examination (MMSE) score <  = 25 were assumed to have cognitive deficit and DESH was evaluated by reviewing the MRIs. We assessed the association between DESH, Evans index (EI), and cognitive deficit using multivariate logistic regression models adjusted for relevant confounders. Furthermore, we evaluated the new development of DESH and the deterioration of cognitive function in the participants with DESH. There were nine participants with DESH (0.65%), seven of whom showed cognitive deficit. DESH was significantly associated with cognitive deficit in multivariate regression analyses (odds ratio; 8.50 [95% confidence interval: 1.61-44.88]). In the 669 participants who underwent follow-up MRI, we found four participants newly presenting with DESH; the development of DESH was observed before/after the presence of EI > 0.3. We also found two participants with existing DESH showing no remarkable worsening in MMSE and EI. The present study demonstrated a positive association between the presence of DESH and cognitive deficit. DESH can develop independently of EI > 0.3, and ventricular enlargement in combination with DESH may be an important factor in the worsening of cognitive deficit.

  200. Five-Year Psychosocial Impact of Living in Postdisaster Prefabricated Temporary Housing. International-journal

    Tetsuya Akaishi, Tomomi Suzuki, Harumi Nemoto, Yusuke Utsumi, Moe Seto, Hitomi Usukura, Yasuto Kunii, Yumi Sugawara, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Atsushi Hozawa, Ichiro Tsuji, Tadashi Ishii, Hiroaki Tomita

    Disaster medicine and public health preparedness　16　(5)　1-9　2021/08/20

    DOI： 10.1017/dmp.2021.214 　

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    OBJECTIVE: This study aims to evaluate the long-term impact of living in postdisaster prefabricated temporary housing on social interaction activities and mental health status. METHODS: A total of 917 adult residents in a coastal town, whose residences were destroyed by the tsunami caused by the Great East Japan Earthquake (GEJE), were enrolled for the assessment held 5 y after the disaster. They answered questions about their experience and consequence of living in prefabricated temporary housing after the disaster. Their present scores on 5 types of self-reported measures regarding the psychosocial or psychiatric status and their present and recalled social interaction activities were cross-sectionally collected. RESULTS: A total of 587 (64.0%) participants had a history of living in prefabricated temporary housing, while the other 330 (36.0%) had not. The prevalence of social interaction activities significantly decreased after the GEJE. However, the experience of living in prefabricated temporary housing did not adversely affect the subsequent social interaction activities or mental conditions of the participants 5 y after the disaster. CONCLUSIONS: Living in postdisaster prefabricated temporary housing may not negatively impact subsequent psychosocial conditions or social interaction activities 5 y later.

  201. Coastal exposure and residents' mental health in the affected areas by the 2011 Great East Japan Earthquake and Tsunami. International-journal

    Ai Tashiro, Mana Kogure, Shohei Nagata, Fumi Itabashi, Naho Tsuchiya, Atsushi Hozawa, Tomoki Nakaya

    Scientific reports　11　(1)　16751-16751　2021/08/18

    DOI： 10.1038/s41598-021-96168-z 　

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    No previous study has ever explored the association between coastal exposure and the mental health of residents in a post-disaster context. Therefore, we aimed to confirm whether there was an association between sea visibility and coastal proximity and the mental health of coastal residents a devastating tsunami. We targeted 15 coastal municipalities located in the Miyagi Prefecture, and obtained data from a community-based cohort study. The baseline survey was initiated 2 years after the 2011 Great East Japan Earthquake and Tsunami and the secondary survey was initiated 6 years after the disaster. We applied multilevel mixed-effects models to the longitudinal data. Our outcome measure was the Kessler Psychological Distress Scale (K6) score. We assessed the data collected from 2,327 respondents on both surveys as of April 2018 for this ongoing cohort study. We found that neither sea visibility nor coastal proximity was significantly associated with the recovery of mental health after the disaster. However, we found a distinctive trend of mental health recovery in people who lived alone with a sea view, indicating that visibility of the sea had a negative effect on their mental health immediately after the GEJET, but that the negative effect was subsequently eliminated.

  202. [Use of simulation models in health economic evaluation studies of dietary salt-reduction policies for cardiovascular disease prevention]. Peer-reviewed

    Hiroki Kato, Nayu Ikeda, Takehiro Sugiyama, Marika Nomura, Katsushi Yoshita, Nobuo Nishi

    [Nihon koshu eisei zasshi] Japanese journal of public health　68　(9)　631-643　2021/07/15

    DOI： 10.11236/jph.20-150 　

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    Objectives Social security costs related to the healthcare and long-term care of patients with cardiovascular diseases is a national burden that is expected to grow as Japan's population ages. Nutritional policies for improving the nation's diet could prevent cardiovascular diseases, but scientific evidence on their costs and outcomes is limited. This study gives an overview of health economic evaluation studies on population-wide dietary salt-reduction policies that have been instituted for the purposes of cardiovascular disease prevention. Thus, this study provides background information for the development of evaluation methods that can be utilized in Japan for analyzing the effects of nutritional policies on public health and social security cost containment.Methods We extracted representative health economic simulation models that are used for predicting the effects of cardiovascular disease-related interventions: Cardiovascular Disease Policy Model, IMPACT Coronary Heart Disease Policy and Prevention Model, US IMPACT Food Policy Model, Assessing Cost-Effectiveness (ACE) approach to priority-setting, and Prevention Impacts Simulation Model (PRISM). Next, we collected original articles on studies that used these models for assessing the costs and effects of national population-wide dietary salt-reduction policies. We then outlined the background, structure, and applied studies associated with each model.Results The five models utilized Markov cohort simulation, microsimulation, proportional multistate life tables, and system dynamics to predict the effect of dietary salt-reduction policies on blood pressure reduction and cardiovascular disease prevention. The models were applied to countries such as Australia, England, and the United States to simulate long-term (10 years to lifetime) costs and effects. These applied studies examined policies that included health promotion campaigns, sodium labels on the front of food packages, and mandatory or voluntary reformulation by the food industry to reduce the salt content of processed foods.Conclusion Health economic simulation modeling is actively being used to evaluate scientific evidence on the costs and outcomes of national dietary salt-reduction policies. Similarly, leveraging simulation modeling techniques could facilitate the evaluation and planning of dietary salt-reduction policies and other nutritional policies in Japan.

  203. The return of individual genomic results to research participants: design and pilot study of Tohoku Medical Megabank Project. International-journal

    Hiroshi Kawame, Akimune Fukushima, Nobuo Fuse, Fuji Nagami, Yoichi Suzuki, Mika Sakurai-Yageta, Jun Yasuda, Yumi Yamaguchi-Kabata, Kengo Kinoshita, Soichi Ogishima, Takako Takai, Shinichi Kuriyama, Atsushi Hozawa, Naoki Nakaya, Tomohiro Nakamura, Naoko Minegishi, Junichi Sugawara, Kichiya Suzuki, Hiroaki Tomita, Akira Uruno, Tomoko Kobayashi, Yayoi Aizawa, Tomoharu Tokutomi, Kayono Yamamoto, Kinuko Ohneda, Shigeo Kure, Yoko Aoki, Hideki Katagiri, Yasushi Ishigaki, Shojiro Sawada, Makoto Sasaki, Masayuki Yamamoto

    Journal of human genetics　67　(1)　9-17　2021/07/08

    DOI： 10.1038/s10038-021-00952-8 　

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    Certain large genome cohort studies attempt to return the individual genomic results to the participants; however, the implementation process and psychosocial impacts remain largely unknown. The Tohoku Medical Megabank Project has conducted large genome cohort studies of general residents. To implement the disclosure of individual genomic results, we extracted the potential challenges and obstacles. Major challenges include the determination of genes/disorders based on the current medical system in Japan, the storage of results, prevention of misunderstanding, and collaboration of medical professionals. To overcome these challenges, we plan to conduct multilayer pilot studies, which deal with different disorders/genes. We finally chose familial hypercholesterolemia (FH) as a target disease for the first pilot study. Of the 665 eligible candidates, 33.5% were interested in the pilot study and provided consent after an educational "genetics workshop" on the basic genetics and medical facts of FH. The genetics professionals disclosed the results to the participants. All positive participants were referred to medical care, and a serial questionnaire revealed no significant psychosocial distress after the disclosure. Return of genomic results to research participants was implemented using a well-prepared protocol. To further elucidate the impact of different disorders, we will perform multilayer pilot studies with different disorders, including actionable pharmacogenomics and hereditary tumor syndromes.

  204. 妊娠・分娩回数と脳血管動脈硬化性変化 大迫研究

    佐藤 和奏, 野村 恭子, 佐藤 倫広, 原 梓, 坪田 恵, 小林 雄紀, 村上 任尚, 戸恒 智子, 廣瀬 卓男, 辰巳 友佳子, 井上 隆輔, 浅山 敬, 菊谷 昌浩, 目時 弘仁, 寶澤 篤, 渡邊 博之, 今井 潤, 大久保 孝義

    東北公衆衛生学会誌　(70)　11-11　2021/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  205. Impacts of the urinary sodium-to-potassium ratio, sleep efficiency, and conventional risk factors on home hypertension in a general Japanese population. International-journal

    Takumi Hirata, Mana Kogure, Naho Tsuchiya, Ken Miyagawa, Akira Narita, Kotaro Nochioka, Akira Uruno, Taku Obara, Tomohiro Nakamura, Naoki Nakaya, Hirohito Metoki, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension　44　(7)　858-865　2021/07

    DOI： 10.1038/s41440-021-00628-y 　

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    Recently, a high urinary sodium-to-potassium (Na/K) ratio and reduced sleep efficiency, in addition to conventional risk factors (obesity and excess alcohol intake), have been identified as risk factors for hypertension. We estimated the population attributable fraction (PAF) for home hypertension due to these risk factors in a general Japanese population. We conducted a cross-sectional study including 1384 participants (393 men and 991 women) to estimate the odds ratio (OR) and 95% confidence interval (CI) for the presence of any of the conventional risk factors using multivariable logistic regression analyses. The models were adjusted for sex, age, smoking status, and log-transformed average daily steps. We also estimated the OR and 95% CI for the presence of any of the overall risk factors. Furthermore, we calculated the PAF due to these risk factors. The results showed that the prevalence of home hypertension was 39.0% (540/1384). The presence of any of the conventional risk factors, as well as any of the overall risk factors, was significantly associated with an increased prevalence of hypertension (OR 2.80, 95% CI 2.15-3.65; OR 2.50, 95% CI 1.93-3.22, respectively). The PAF for hypertension due to the presence of any of the conventional risk factors and the PAF due to the presence of any of the overall risk factors were 30.2% and 39.0%, respectively. In conclusion, the impact of the overall risk factors, including the urinary Na/K ratio and sleep efficiency, on home hypertension was higher than that of conventional risk factors alone. The management of the urinary Na/K ratio and sleep efficiency as well as conventional risk factors might be important in the management of blood pressure.

  206. Association of self-measured home, ambulatory, and strictly measured office blood pressure and their variability with intracranial arterial stenosis International-journal

    Takashi Hisamatsu, Takayoshi Ohkubo, Atsushi Hozawa, Akira Fujiyoshi, Sayuki Torii, Hiroyoshi Segawa, Keiko Kondo, Aya Kadota, Naoyuki Takashima, Satoshi Shitara, Hisatomi Arima, Yoshihisa Nakagawa, Yoshiyuki Watanabe, Akihiko Shiino, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura

    Journal of Hypertension　Publish Ahead of Print　(10)　2030-2039　2021/06/23

    Publisher: Ovid Technologies (Wolters Kluwer Health)

    DOI： 10.1097/hjh.0000000000002900 　

    ISSN： 0263-6352

    eISSN： 1473-5598

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    OBJECTIVE: Hypertension and intracranial artery stenosis (ICAS) are closely related; however, few studies have compared the strength of the relationship between strictly measured office and out-of-office blood pressure (BP) measurements. The relationship of day-by-day or short-term variability in BP to asymptomatic ICAS also remains unclear. METHODS: In apparently healthy 677 men (mean age, 70 years) from a population-based cohort, we examined the association of strictly measured office BP and 7-day home BP with ICAS on magnetic resonance angiography. We conducted 24-h ambulatory BP monitoring in 468 of the men. Variability indices included day-by-day, daytime, and night-time variability, nocturnal decline, and morning pressor surge. Any ICAS was defined as either mild (1-49%) or severe (≥50%) stenosis. RESULTS: We observed mild and severe ICAS in 153 (22.6%) and 36 (5.3%) participants, respectively. In multivariable-adjusted Poisson regression with robust error variance, higher SBP in office, home, or ambulatory BP monitoring was associated with the presence of any or severe ICAS. The associations with ICAS were comparable between office, home, and ambulatory SBP (all heterogeneity P values >0.1). Independent of mean SBP, greater nocturnal decline or morning pressor surge, but not day-by-day, daytime, or night-time variability, in SBP was associated with higher burden of any or severe ICAS. CONCLUSION: The magnitude of association of strictly measured office BP for asymptomatic ICAS was comparable with that of BP measured at home or in ambulatory BP monitoring. Circadian BP variation based on ambulatory BP monitoring was positively associated with asymptomatic ICAS burden.

  207. Five-year Psychosocial Impact of Living in Post-Disaster Prefabricated Temporary Housing. International-journal

    Tetsuya Akaishi, Tomomi Suzuki, Harumi Nemoto, Yusuke Utsumi, Moe Seto, Hitomi Usukura, Yasuto Kunii, Yumi Sugawara, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Atsushi Hozawa, Ichiro Tsuji, Tadashi Ishii, Hiroaki Tomita

    Disaster medicine and public health preparedness　1-31　2021/06/23

    DOI： 10.1017/dmp.2021.212 　

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    OBJECTIVE: This study aims to evaluate the long-term impact of living in post-disaster prefabricated temporary housing on social interaction activities and mental health status. METHODS: A total of 917 adult residents in a coastal town, whose residences were destroyed by the tsunami caused by the Great East Japan Earthquake (GEJE), were enrolled for the assessment held five years after the disaster. They answered questions about their experience and consequence of living in prefabricated temporary housing after the disaster. Their present scores on five types of self-reported measures regarding the psychosocial or psychiatric status and their present and recalled social interaction activities were cross-sectionally collected. RESULTS: A total of 587 (64.0%) participants had a history of living in prefabricated temporary housing, while the other 330 (36.0%) had not. The prevalence of social interaction activities significantly decreased after the GEJE. However, the experience of living in prefabricated temporary housing did not adversely affect the subsequent social interaction activities or mental conditions of the participants five years after the disaster. CONCLUSIONS: Living in post-disaster prefabricated temporary housing may not negatively impact subsequent psychosocial conditions or social interaction activities five years later.

  208. 血清尿酸値と平均5年後の慢性腎臓病発症に関する中壮年の男女別での関連性

    中山 晋吾, 佐藤 倫広, 村上 任尚, 辰巳 友佳子, 室谷 智子, 廣瀬 卓男, 大久保 孝義, 森 建文, 寳澤 篤, 目時 弘仁

    日本腎臓学会誌　63　(4)　469-469　2021/06

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  209. 血清尿酸値と平均5年後の慢性腎臓病発症に関する中壮年の男女別での関連性

    中山 晋吾, 佐藤 倫広, 村上 任尚, 辰巳 友佳子, 室谷 智子, 廣瀬 卓男, 大久保 孝義, 森 建文, 寳澤 篤, 目時 弘仁

    日本腎臓学会誌　63　(4)　469-469　2021/06

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  210. Detailed association between serum uric acid levels and the incidence of chronic kidney disease stratified by sex in middle-aged adults International-journal

    Shingo Nakayama, Michihiro Satoh, Yukako Tatsumi, Takahisa Murakami, Tomoko Muroya, Takuo Hirose, Takayoshi Ohkubo, Takefumi Mori, Atsushi Hozawa, Hirohito Metoki

    Atherosclerosis　330　107-113　2021/06

    Publisher: Elsevier BV

    DOI： 10.1016/j.atherosclerosis.2021.06.908 　

    ISSN： 0021-9150

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    BACKGROUND AND AIMS: Chronic kidney disease (CKD) is a global health burden. Previous studies have shown a J- or U-shaped association between serum uric acid (SUA) and cardiovascular mortality. We assessed the risk of CKD incidence in a refined SUA category in middle-aged adults stratified by sex. METHODS: We analyzed data from 138,511 participants <65 years old (29.6% women; mean age 44.1 years) without CKD at baseline acquired from the JMDC database. The Cox model was used to assess the adjusted hazard ratio (HR). RESULTS: During the mean follow-up period of 4.68 years, 12,589 participants developed CKD. The fully adjusted HRs (95% confidence interval [CI], p-value) for CKD incidence in men with SUA <4.0, 10.0-10.9 and ≥ 11.0 mg/dL compared to men with SUA 4.0-4.9 mg/dL were 1.13 (1.01-1.26, p = 0.030), 1.98 (1.32-2.97, p = 0.0010), and 3.74 (1.68-8.35, p = 0.0013), respectively. The fully adjusted HRs for CKD incidence in women with SUA <4.0, 8.0-8.9, and ≥9.0 mg/dL compared to women with SUA 4.0-4.9 mg/dL were 1.08 (1.01-1.16, p = 0.032), 2.39 (1.07-5.35, p = 0.034), and 3.20 (0.80-12.8, p = 0.10), respectively. CONCLUSIONS: Both high and low SUA levels were identified as risk factors for CKD incidence in middle-aged men and women. The association of SUA levels with the increase in the risk of CKD incidence differed by sex, and the range of SUA levels associated with an increase in the risk of CKD incidence varied by sex.

  211. Oral health-related quality of life is associated with the prevalence and development of depressive symptoms in older Japanese individuals: The Ohasama Study. International-journal

    Takashi Ohi, Takahisa Murakami, Takamasa Komiyama, Yoshitada Miyoshi, Kosei Endo, Takako Hiratsuka, Michihiro Satoh, Kei Asayama, Ryusuke Inoue, Masahiro Kikuya, Hirohito Metoki, Atsushi Hozawa, Yutaka Imai, Makoto Watanabe, Takayoshi Ohkubo, Yoshinori Hattori

    Gerodontology　39　(2)　204-212　2021/05/19

    DOI： 10.1111/ger.12557 　

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    OBJECTIVE: This prospective study investigated the cross-sectional association between impaired oral health-related quality of life (OHRQoL) and the prevalence of depressive symptoms, and the longitudinal association between impaired OHRQoL and development of depressive symptoms among older adults. BACKGROUND: Previous studies have shown a relationship between poor oral health and depression among older adults; however, findings are inconsistent. MATERIALS AND METHODS: Participants were 669 community-dwelling older Japanese individuals aged≥55 years (mean: 67.8 ± 7.2 years). Data of 296 participants were used for longitudinal analyses. OHRQoL was evaluated using the Oral Impacts on Daily Performances scale. Impaired OHRQoL was defined as the presence of at least one impact on the scale. Depressive symptoms were assessed using the Japanese version of the Zung self-rating depression scale with a cut-off score of 40. RESULTS: The cross-sectional logistic regression model demonstrated that impaired OHRQoL was significantly associated with depressive symptoms (odds ratio [OR], 5.17; 95% confidence interval [CI], 2.99-8.95) independent of age, sex, body mass index, hypertension, cerebrovascular/cardiovascular disease, smoking, drinking alcohol, education, cognitive function, objective oral health (dentition status) and oral health behaviour (dental visit within 1 year). Similarly, impaired OHRQoL predicted the development of depressive symptoms within 4 years in a fully adjusted longitudinal model (OR, 6.00; 95% CI, 1.38-26.09). CONCLUSION: Impaired OHRQoL was identified as a potential comorbidity of depressive symptoms and a predictor for depressive disorder later in life. OHRQoL may be a useful clinical outcome for elder patients with regard to their mental and oral health.

  212. Correction to: Genome-wide association study identifies new loci for albuminuria in the Japanese population.

    Hiroshi Okuda, Koji Okamoto, Michiaki Abe, Kota Ishizawa, Satoshi Makino, Osamu Tanabe, Junichi Sugawara, Atsushi Hozawa, Kozo Tanno, Makoto Sasaki, Gen Tamiya, Masayuki Yamamoto, Sadayoshi Ito, Tadashi Ishii

    Clinical and experimental nephrology　25　(5)　565-565　2021/05

    DOI： 10.1007/s10157-021-02053-4 　

  213. GWAS Identified IL4R and the Major Histocompatibility Complex Region as the Associated Loci of Total Serum IgE Levels in 9,260 Japanese Individuals. International-journal

    Kosuke Shido, Kaname Kojima, Matsuyuki Shirota, Kenshi Yamasaki, Ikuko N Motoike, Atsushi Hozawa, Soichi Ogishima, Naoko Minegishi, Kozo Tanno, Fumiki Katsuoka, Gen Tamiya, Setsuya Aiba, Masayuki Yamamoto, Kengo Kinoshita

    The Journal of investigative dermatology　141　(11)　2749-2752　2021/04/14

    DOI： 10.1016/j.jid.2021.02.762 　

  214. Lifetime risk of stroke stratified by chronic kidney disease and hypertension in the general Asian population: the Ohasama study International-journal

    Shingo Nakayama, Michihiro Satoh, Hirohito Metoki, Takahisa Murakami, Kei Asayama, Azusa Hara, Takuo Hirose, Atsuhiro Kanno, Ryusuke Inoue, Megumi Tsubota-Utsugi, Masahiro Kikuya, Takefumi Mori, Atsushi Hozawa, Yutaka Imai, Takayoshi Ohkubo

    Hypertension Research　44　(7)　866-873　2021/03/19

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41440-021-00635-z 　

    ISSN： 0916-9636

    eISSN： 1348-4214

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    Lifetime risk (LTR) evaluates the absolute risk of developing a disease during the remainder of one's life. It can be a useful tool, enabling the general public to easily understand their risk of stroke. No study has been performed to determine the LTR of cardiovascular disease in patients with chronic kidney disease (CKD) with or without hypertension; therefore, we performed this study in an Asian population. We followed 1525 participants (66.0% women; age 63.1 years) in the general population of Ohasama, Japan. We defined CKD as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 and/or proteinuria. Hypertension was defined as a systolic/diastolic blood pressure ≥140/≥90 mmHg and/or the use of antihypertensive medication. We calculated the sex-specific LTR of stroke adjusted for the competing risk of death. During the mean follow-up period of 16.5 years, a first stroke occurred in 238 participants. The 10-year risk of stroke at the age of 45 years was 0.0% for men and women. The LTRs of stroke at the index age of 45 years (men/women) were 20.9%/14.5% for participants without CKD and hypertension, 34.1%/29.8% for those with CKD but not hypertension, 37.9%/27.3% for those with hypertension but not CKD, and 38.4%/36.4% for those with CKD and hypertension. The LTRs of stroke tended to be higher in younger participants than in older participants with CKD and/or hypertension. CKD contributed to the LTR of stroke, as did hypertension. The prevention of CKD and hypertension can reduce the LTR of stroke, especially in young populations.

  215. Correction: Sodium/potassium ratio change was associated with blood pressure change: possibility of population approach for sodium/potassium ratio reduction in health checkup. International-journal

    Mana Kogure, Naoki Nakaya, Takumi Hirata, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Yoko Suto, Yoko Honma, Hidemi Sasaki, Ken Miyagawa, Yusuke Ushida, Hiroyuki Ueda, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension　44　(2)　262-262　2021/02

    DOI： 10.1038/s41440-020-00547-4 　

  216. Sodium/potassium ratio change was associated with blood pressure change: possibility of population approach for sodium/potassium ratio reduction in health checkup. International-journal Peer-reviewed

    Mana Kogure, Naoki Nakaya, Takumi Hirata, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Yoko Suto, Yoko Honma, Hidemi Sasaki, Ken Miyagawa, Yusuke Ushida, Hiroyuki Ueda, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension　44　(2)　225-231　2021/02

    DOI： 10.1038/s41440-020-00536-7 　

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    Recently, the sodium (Na)/potassium (K) ratio was reported to be associated with blood pressure (BP). A Na/K ratio self-monitoring device using spot urine was established recently. Here, we assessed whether the urinary Na/K ratio change measured using the Na/K device was associated with BP change in a health checkup setting. We targeted 12,890 participants who attended the health checkup in Tome City, Miyagi between 2017 and 2018. Tome City introduced urinary Na/K ratio measurements during health checkups since 2017. For each year, we compared the baseline characteristics according to the urinary Na/K ratio and BP level. We assessed the relationship between change in urinary Na/K ratio and BP change using multiple regression analyses adjusted for age, sex, and change in body mass index (BMI) and alcohol intake. The average urinary Na/K ratio was significantly lower in 2018 than in 2017 (5.4 ± 3.0 to 4.9 ± 2.2, P < 0.01). The systolic BP of the participants in 2018 (130.9 ± 17.4 mmHg) was lower than that in 2017 (132.1 ± 17.9 mmHg). Moreover, the change in systolic BP and diastolic BP was positively associated with the change in urinary Na/K ratio. In conclusion, the association of the change in urinary Na/K ratio with hypertension and changes in systolic and diastolic BP can be explained by a change in alcohol intake, BMI, and urinary Na/K ratio. Therefore, measuring the urinary Na/K ratio in community settings is a potential population approach for counteracting hypertension.

  217. Body mass index and colorectal cancer risk: a Mendelian randomization study. International-journal

    Shiori Suzuki, Atsushi Goto, Masahiro Nakatochi, Akira Narita, Taiki Yamaji, Norie Sawada, Ryoko Katagiri, Masao Iwagami, Akiko Hanyuda, Tsuyoshi Hachiya, Yoichi Sutoh, Isao Oze, Yuriko N Koyanagi, Yumiko Kasugai, Yukari Taniyama, Hidemi Ito, Hiroaki Ikezaki, Yuichiro Nishida, Takashi Tamura, Haruo Mikami, Toshiro Takezaki, Sadao Suzuki, Etsuko Ozaki, Kiyonori Kuriki, Naoyuki Takashima, Kokichi Arisawa, Kenji Takeuchi, Kozo Tanno, Atsushi Shimizu, Gen Tamiya, Atsushi Hozawa, Kengo Kinoshita, Kenji Wakai, Makoto Sasaki, Masayuki Yamamoto, Keitaro Matsuo, Shoichiro Tsugane, Motoki Iwasaki

    Cancer science　112　(4)　1579-1588　2021/01/27

    DOI： 10.1111/cas.14824 　

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    Traditional observational studies have reported a positive association between higher body mass index (BMI) and the risk of colorectal cancer (CRC). However, evidence from other approaches to pursue the causal relationship between BMI and CRC is sparse. A two-sample Mendelian randomization (MR) study was performed using 68 single nucleotide polymorphisms (SNPs) from the Japanese genome-wide association study (GWAS) and 654 SNPs from the GWAS catalogue for BMI as sets of instrumental variables. For the analysis of SNP-BMI associations, we conducted a meta-analysis with 36 303 participants in the Japanese Consortium of Genetic Epidemiology studies, comprising of normal populations. For the analysis of SNP-CRC associations, we utilized 7636 CRC cases and 37 141 controls from five studies in Japan, and performed a meta-analysis. MR analysis of inverse-variance weighted method indicated that a one-unit (kg/m2 ) increase in genetically predicted BMI was associated with an odds ratio of 1.13 (95% confidence interval 1.06 to 1.20, P value <0.001) for CRC using the set of 68 SNPs, and an odds ratio of 1.07 (1.03 to 1.11, 0.001) for CRC using the set of 654 SNPs. Sensitivity analyses robustly showed increased odds ratios for CRC for every one-unit increase in genetically predicted BMI. Our MR analyses strongly support the evidence that higher BMI influences the risk of CRC. Although Asians are generally leaner than Westerns, avoiding higher BMI seems to be important for the prevention of CRC in Asian populations.

  218. Risk factors that most accurately predict coronary artery disease based on the duration of follow-up ― NIPPON DATA80 ―

    Yukiko Okami, Hirotsugu Ueshima, Yasuyuki Nakamura, Keiko Kondo, Aya Kadota, Nagako Okuda, Takayoshi Ohkubo, Naomi Miyamatsu, Tomonori Okamura, Katsuyuki Miura, Akira Okayama, Shigeyuki Saitoh, Kiyomi Sakata, Atsushi Hozawa, Yosikazu Nakamura, Nobuo Nishi, Fumiyoshi Kasagi, Yoshitaka Murakami, Tohru Izumi, Yasuhiro Matsumura, Toshiyuki Ojima, Koji Tamakoshi, Hideaki Nakagawa, Yoshikuni Kita, Takehito Hayakawa, Katsushi Yoshita, Yoshihiro Miyamoto, Akira Fujiyoshi, Kazunori Kodama, Yutaka Kiyohara

    Circulation Journal　85　(6)　908-913　2021

    DOI： 10.1253/circj.CJ-20-0739 　

    ISSN： 1346-9843

    eISSN： 1347-4820

  219. 脂肪量指数および除脂肪量指数の組み合わせとHbA1cとの関連

    高瀬 雅仁, 中村 智洋, 平田 匠, 小暮 真奈, 板橋 芙美, 土屋 菜歩, 中谷 直樹, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    Journal of Epidemiology　31　(Suppl.)　101-101　2021/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  220. 東北メディカル・メガバンク計画地域住民コホート 特定健診共同参加型対象者の基礎特性とがん罹患の関連

    寳澤 篤, 小原 拓, 中村 智洋, 板橋 芙美, 小暮 真奈, 成田 暁, 土屋 菜歩, 平田 匠, 中谷 直樹, 菅原 準一, 栗山 進一, 布施 昇男, 辻 一郎, 呉 繁夫

    Journal of Epidemiology　31　(Suppl.)　116-116　2021/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  221. 住環境の主観的評価と心理的苦痛との関連

    菅野 郁美, 長谷川 兼一, 中村 智洋, 土屋 菜歩, 小暮 真奈, 板橋 芙美, 成田 暁, 平田 匠, 中谷 直樹, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    Journal of Epidemiology　31　(Suppl.)　143-143　2021/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  222. 脂肪量指数および除脂肪量指数の組み合わせとHbA1cとの関連

    高瀬 雅仁, 中村 智洋, 平田 匠, 小暮 真奈, 板橋 芙美, 土屋 菜歩, 中谷 直樹, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    Journal of Epidemiology　31　(Suppl.)　101-101　2021/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  223. 東北メディカル・メガバンク計画地域住民コホート 特定健診共同参加型対象者の基礎特性とがん罹患の関連

    寳澤 篤, 小原 拓, 中村 智洋, 板橋 芙美, 小暮 真奈, 成田 暁, 土屋 菜歩, 平田 匠, 中谷 直樹, 菅原 準一, 栗山 進一, 布施 昇男, 辻 一郎, 呉 繁夫

    Journal of Epidemiology　31　(Suppl.)　116-116　2021/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  224. 住環境の主観的評価と心理的苦痛との関連

    菅野 郁美, 長谷川 兼一, 中村 智洋, 土屋 菜歩, 小暮 真奈, 板橋 芙美, 成田 暁, 平田 匠, 中谷 直樹, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    Journal of Epidemiology　31　(Suppl.)　143-143　2021/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  225. Relationships of Alcohol Consumption with Coronary Risk Factors and Macro- and Micro-Nutrient Intake in Japanese People: The INTERLIPID Study.

    Hiromi Matsumoto-Yamauchi, Keiko Kondo, Katsuyuki Miura, Sachiko Tanaka-Mizuno, Hiroyoshi Segawa, Seiko Ohno, Naoko Miyagawa, Maryam Zaid, Yukiko Okami, Nagako Okuda, Hideaki Nakagawa, Kiyomi Sakata, Shigeyuki Saitoh, Akira Okayama, Katsushi Yoshita, Queenie Chan, Kamal Masaki, Paul Elliott, Jeremiah Stamler, Hirotsugu Ueshima

    Journal of nutritional science and vitaminology　67　(1)　28-38　2021

    DOI： 10.3177/jnsv.67.28 　

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    Several studies have reported a J-shaped relationship between alcohol consumption and coronary heart disease (CHD) risk. However, the mechanisms of this relationship remain unclear. This study aimed to evaluate the relationships of alcohol consumption with established CHD risk factors and with macro-/micro-nutrient intake among Japanese people. Participants were 1,090 Japanese men and women aged 40-59 y enrolled in the INTERLIPID study, excluding former drinkers. Based on two 7-d alcohol records, participants were classified as non-drinkers (0 g/wk), light-drinkers (<100 g/wk), moderate-drinkers (100-299 g/wk), or heavy-drinkers (≥300 g/wk). Detailed macro-/micro-nutrient intake was evaluated using four in-depth 24-h dietary recalls and adjusted for total energy intake excluding alcohol. We analyzed the associations of CHD risk factors and nutrient intake with alcohol consumption. Serum high-density lipoprotein cholesterol and blood pressure were higher and low-density lipoprotein cholesterol was lower among those with higher alcohol consumption. J-shaped relationships with alcohol consumption were observed for the proportion of current smokers, number of cigarettes smoked, and prevalence of hypertension; these risk factors were lowest among light-drinkers. Carbohydrate and total fiber intakes were lower and protein and dietary cholesterol intakes were higher among those with higher alcohol consumption. These associations were similar for men and women. Alcohol consumption was related to nutrient intake as well as established CHD risk factors. Non-drinkers were higher on some CHD risk factors than were light-drinkers. These findings may influence the J-shaped relationship between alcohol consumption and CHD risk.

  226. Differences between home blood pressure and strictly measured office blood pressure and their determinants in Japanese men. International-journal

    Sayaka Kadowaki, Takashi Kadowaki, Atsushi Hozawa, Akira Fujiyoshi, Takashi Hisamatsu, Atsushi Satoh, Hisatomi Arima, Sachiko Tanaka, Sayuki Torii, Keiko Kondo, Aya Kadota, Kamal Masaki, Tomonori Okamura, Takayoshi Ohkubo, Katsuyuki Miura, Hirotsugu Ueshima

    Hypertension research : official journal of the Japanese Society of Hypertension　44　(1)　80-87　2021/01

    DOI： 10.1038/s41440-020-00533-w 　

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    Conventional office blood pressure (OBP) and home blood pressure (HBP) measurements are often inconsistent. The purpose of this research was (1) to test whether strictly measured OBP values with sufficient rest time before measurement (st-OBP) is comparable to HBP at the population level and (2) to ascertain whether there are particular determinants for the difference between HBP and st-OBP at the individual level. Data from a population-based group of 1056 men aged 40-79 years were analyzed. After a five-min rest, st-OBP was measured twice. HBP was measured after a 2-min rest every morning for seven consecutive days. To determine factors related to ΔSBP (HBP minus st-OBP measurements), multiple linear regression analyses and analyses of covariance were performed. While st-OBP and HBP were comparable (136.5 vs. 137.2 mmHg) at the population level, ΔSBP varied with a standard deviation of 13.5 mmHg. Smoking was associated with a larger ΔSBP regardless of antihypertensive usage, and BMI was associated with a larger ΔSBP in participants using antihypertensive drugs. The adjusted mean ΔSBP in the highest BMI tertile category was 4.6 mmHg in participants taking antihypertensive drugs. st-OBP and HBP measurements were comparable at the population level, although the distribution of ΔSBP was considerably broad. Smokers and obese men taking antihypertensive drugs had higher HBP than st-OBP, indicating that their blood pressure levels are at risk of being underestimated. Therefore, this group would benefit from the addition of HBP measurements.

  227. Novel candidates of pathogenic variants of the BRCA1 and BRCA2 genes from a dataset of 3,552 Japanese whole genomes (3.5KJPNv2). International-journal

    Hideki Tokunaga, Keita Iida, Atsushi Hozawa, Soichi Ogishima, Yoh Watanabe, Shogo Shigeta, Muneaki Shimada, Yumi Yamaguchi-Kabata, Shu Tadaka, Fumiki Katsuoka, Shin Ito, Kazuki Kumada, Yohei Hamanaka, Nobuo Fuse, Kengo Kinoshita, Masayuki Yamamoto, Nobuo Yaegashi, Jun Yasuda

    PloS one　16　(1)　e0236907　2021

    DOI： 10.1371/journal.pone.0236907 　

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    Identification of the population frequencies of definitely pathogenic germline variants in two major hereditary breast and ovarian cancer syndrome (HBOC) genes, BRCA1/2, is essential to estimate the number of HBOC patients. In addition, the identification of moderately penetrant HBOC gene variants that contribute to increasing the risk of breast and ovarian cancers in a population is critical to establish personalized health care. A prospective cohort subjected to genome analysis can provide both sets of information. Computational scoring and prospective cohort studies may help to identify such likely pathogenic variants in the general population. We annotated the variants in the BRCA1 and BRCA2 genes from a dataset of 3,552 whole-genome sequences obtained from members of a prospective cohorts with genome data in the Tohoku Medical Megabank Project (TMM) with InterVar software. Computational impact scores (CADD_phred and Eigen_raw) and minor allele frequencies (MAFs) of pathogenic (P) and likely pathogenic (LP) variants in ClinVar were used for filtration criteria. Familial predispositions to cancers among the 35,000 TMM genome cohort participants were analyzed to verify the identified pathogenicity. Seven potentially pathogenic variants were newly identified. The sisters of carriers of these moderately deleterious variants and definite P and LP variants among members of the TMM prospective cohort showed a statistically significant preponderance for cancer onset, from the self-reported cancer history. Filtering by computational scoring and MAF is useful to identify potentially pathogenic variants in BRCA genes in the Japanese population. These results should help to follow up the carriers of variants of uncertain significance in the HBOC genes in the longitudinal prospective cohort study.

  228. Combined associations of liver enzymes and obesity with diabetes mellitus prevalence: The Tohoku Medical Megabank Community-based Cohort Study.

    Fumi Itabashi, Takumi Hirata, Mana Kogure, Akira Narita, Naho Tsuchiya, Tomohiro Nakamura, Naoki Nakaya, Ryohei Sasaki, Nobuyuki Takanashi, Kiyomi Sakata, Kozo Tanno, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Journal of epidemiology　32　(5)　221-227　2020/12/26

    DOI： 10.2188/jea.JE20200384 　

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    BACKGROUND: Alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) are enzymes associated with diabetes mellitus (DM) prevalence. However, limited information is available regarding the association of liver enzymes and DM consistently present in obese and non-obese individuals. We examined whether the combination of ALT and GGT enzymes is associated with the prevalence of DM regardless of obesity in a general Japanese population. METHODS: We conducted a cross-sectional study of 62,786 participants aged ≥20 years who lived in Miyagi and Iwate, Japan. We divided all the participants into eight groups according to the ALT level (low: <30 IU/L and high: ≥30 IU/L), GGT level (low: <50 IU/L and high: ≥50 IU/L), and the presence of obesity. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using multivariable logistic regression analysis, adjusting for potential confounders, to determine associations of the combination of ALT and GGT levels and obesity with DM prevalence. RESULTS: Overall, 6,008 participants (9.6%) had DM. Compared to non-obese individuals with low ALT and GGT levels, the participants with high ALT and GGT levels had high ORs for DM in both obese (OR 4.06; 95% CI, 3.61-4.56) and non-obese groups (OR 2.19; 95% CI, 1.89-2.52). The obese group had high ORs for DM, even at low ALT and GGT levels. CONCLUSION: High ALT and GGT levels are associated with DM prevalence in obese and non-obese participants. This finding suggests that correcting ALT and GGT levels and controlling obesity are important for the prevention of DM.

  229. Machine learning to reveal hidden risk combinations for the trajectory of posttraumatic stress disorder symptoms. International-journal

    Yuta Takahashi, Kazuki Yoshizoe, Masao Ueki, Gen Tamiya, Yu Zhiqian, Yusuke Utsumi, Atsushi Sakuma, Koji Tsuda, Atsushi Hozawa, Ichiro Tsuji, Hiroaki Tomita

    Scientific reports　10　(1)　21726-21726　2020/12/10

    DOI： 10.1038/s41598-020-78966-z 　

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    The nature of the recovery process of posttraumatic stress disorder (PTSD) symptoms is multifactorial. The Massive Parallel Limitless-Arity Multiple-testing Procedure (MP-LAMP), which was developed to detect significant combinational risk factors comprehensively, was utilized to reveal hidden combinational risk factors to explain the long-term trajectory of the PTSD symptoms. In 624 population-based subjects severely affected by the Great East Japan Earthquake, 61 potential risk factors encompassing sociodemographics, lifestyle, and traumatic experiences were analyzed by MP-LAMP regarding combinational associations with the trajectory of PTSD symptoms, as evaluated by the Impact of Event Scale-Revised score after eight years adjusted by the baseline score. The comprehensive combinational analysis detected 56 significant combinational risk factors, including 15 independent variables, although the conventional bivariate analysis between single risk factors and the trajectory detected no significant risk factors. The strongest association was observed with the combination of short resting time, short walking time, unemployment, and evacuation without preparation (adjusted P value = 2.2 × 10-4, and raw P value = 3.1 × 10-9). Although short resting time had no association with the poor trajectory, it had a significant interaction with short walking time (P value = 1.2 × 10-3), which was further strengthened by the other two components (P value = 9.7 × 10-5). Likewise, components that were not associated with a poor trajectory in bivariate analysis were included in every observed significant risk combination due to their interactions with other components. Comprehensive combination detection by MP-LAMP is essential for explaining multifactorial psychiatric symptoms by revealing the hidden combinations of risk factors.

  230. 宮城県立学校教職員における時間外労働時間と生活習慣病、抑うつ保有との関係

    宗像 正徳, 服部 朝美, 中山 文恵, 金野 敏, 長澤 美穂, 井上 信孝, 中村 智洋, 寶澤 篤

    日本職業・災害医学会会誌　68　(臨増)　別183-別183　2020/12

    Publisher: (一社)日本職業・災害医学会

    ISSN： 1345-2592

  231. Impact of the Great East Japan Earthquake on the Employment Status and Mental Health Conditions of Affected Coastal Communities. International-journal

    Mitsuaki Katayanagi, Moe Seto, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Yumi Sugawara, Akira Kodaka, Yusuke Utsumi, Hitomi Usukura, Yasuto Kunii, Atsushi Hozawa, Ichiro Tsuji, Hiroaki Tomita

    International journal of environmental research and public health　17　(21)　2020/11/03

    DOI： 10.3390/ijerph17218130 　

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    The Great East Japan Earthquake devasted the old community in coastal areas characterized by primary industry. The number of unemployed people increased from 150,000 to 190,000 after the earthquake. All of the adult residents of Shichigahama (18 years old or older), located in the coastal area of the Miyagi prefecture, whose houses were totally or majorly damaged, were recruited for a survey conducted in October 2011. All of the residents who responded with written informed consent were included in this study. Among 904 individuals who had a job before the Great East Japan Earthquake, 19% became unemployed. Concerning gender and age, 9% of young men, 34% of elderly men, 21% of young women, and 49% of elderly women became unemployed. Concerning the type of industry, 38%, 15%, and 16% of people who had belonged to the primary, secondary, and tertiary industries, respectively, before the disaster became unemployed. Those who became unemployed exhibited a significantly higher risk of insomnia compared to those who maintained jobs. The study pointed out the severe impact of the Great East Japan Earthquake on populations who had belonged to the primary industry, especially among elderly women, and its effect on sleep conditions.

  232. 東北メディカル・メガバンク計画(宮城)における頸動脈エコーについて

    寳澤 篤, 土屋 菜歩, 中村 智洋, 宇留野 晃, 栗山 進一, 菅原 準一, 呉 繁夫, 布施 昇男, 山本 雅之

    超音波医学　47　(Suppl.)　S532-S532　2020/11

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  233. Blood Pressure Phenotypes Defined by Ambulatory Blood Pressure Monitoring and Carotid Artery Changes in Community-Dwelling Older Japanese Adults: The Ohasama Study.

    Ayami Fujita, Azusa Hara, Masahiro Kikuya, Kei Asayama, Michihiro Satoh, Kaori Asakura, Yoriko Shintani, Shinya Uchida, Yuko Takatsuji, Takahisa Murakami, Takuo Hirose, Megumi Tsubota-Utsugi, Ryusuke Inoue, Kyoko Nomura, Hirohito Metoki, Atsushi Hozawa, Seiko Miyazaki, Yutaka Imai, Takayoshi Ohkubo

    The Tohoku journal of experimental medicine　252　(3)　269-279　2020/11

    DOI： 10.1620/tjem.252.269 　

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    White coat hypertension is defined as elevated blood pressure in the office, but a normal blood pressure out-of-office, whereas masked hypertension is defined as elevated blood pressure in the office, but normal out-of-office blood pressure. The objective was to investigate the associations between these blood pressure phenotypes and carotid artery changes. Conventional blood pressure, ambulatory blood pressure, and carotid ultrasonography were evaluated in 851 Ohasama residents (31.8% men; mean age 66.3 years). The blood pressure phenotypes were defined by the ordinary thresholds (140/90 mmHg for conventional blood pressure, 135/85 mmHg for daytime blood pressure) and then by the 2017 American College of Cardiology/American Heart Association (ACC/AHA) thresholds for hypertension (130/80 mmHg for both conventional and daytime blood pressure), irrespective of antihypertensive medication treatment status. Blood pressure phenotypes were linearly associated with the mean intima-media thickness of the carotid artery in ascending order for sustained normal blood pressure, white coat hypertension, masked hypertension, and sustained hypertension according to the ordinary thresholds and the 2017 ACC/AHA thresholds (both linear trends P < 0.0001) after adjustments for possible confounding factors. The odds ratios for the presence of carotid plaques showed similar linear trends with the blood pressure phenotypes according to the 2017 ACC/AHA thresholds (linear trend P < 0.0191). In conclusion, there was a close relationship between blood pressure phenotypes and carotid artery changes, suggesting that blood pressure phenotypes as defined by ambulatory blood pressure are potentially useful for risk stratification of carotid artery changes in the Japanese general population.

  234. Hypertensive disorders of pregnancy, obesity, and hypertension in later life by age group: a cross-sectional analysis. International-journal Peer-reviewed

    Maiko Wagata, Mana Kogure, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Takumi Hirata, Akira Narita, Hirohito Metoki, Mami Ishikuro, Masahiro Kikuya, Kozo Tanno, Akimune Fukushima, Nobuo Yaegashi, Shigeo Kure, Masayuki Yamamoto, Shinichi Kuriyama, Atsushi Hozawa, Junichi Sugawara

    Hypertension research : official journal of the Japanese Society of Hypertension　43　(11)　1277-1283　2020/11

    DOI： 10.1038/s41440-020-0463-8 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  235. Maternal Baseline Characteristics and Perinatal Outcomes: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

    Junichi Sugawara, Mami Ishikuro, Taku Obara, Tomomi Onuma, Keiko Murakami, Masahiro Kikuya, Fumihiko Ueno, Aoi Noda, Satoshi Mizuno, Tomoko Kobayashi, Yohei Hamanaka, Kichiya Suzuki, Eiichi Kodama, Naho Tsuchiya, Akira Uruno, Yoichi Suzuki, Osamu Tanabe, Hideyasu Kiyomoto, Akito Tsuboi, Atsushi Shimizu, Seizo Koshiba, Naoko Minegishi, Soichi Ogishima, Gen Tamiya, Hirohito Metoki, Atsushi Hozawa, Nobuo Fuse, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Shinichi Kuriyama, Masayuki Yamamoto

    Journal of epidemiology　32　(2)　69-79　2020/10/10

    DOI： 10.2188/jea.JE20200338 　

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    BACKGROUND: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study was launched in 2013 to evaluate the complex interactions of genetic and environmental factors in multifactorial diseases. The present study describes the maternal baseline profile and perinatal data of participating mothers and infants. METHODS: Expectant mothers living in Miyagi prefecture were recruited from obstetric facilities or affiliated centers between 2013 and 2017. Three sets of self-administered questionnaires were collected, and the medical records were reviewed to obtain precise information about each antenatal visit and each delivery. Biospecimens, including blood, urine, umbilical cord blood, and breast milk, were collected for the study biobank. The baseline maternal sociodemographic characteristics, results of screening tests, and obstetric outcomes were analyzed according to the maternal age group. RESULTS: A total of 23 406 pregnancies involving 23 730 fetuses resulted in 23 143 live births. Younger maternal participants had a tendency toward a higher incidence of threatened abortion and threatened premature labor, while older age groups exhibited a significantly higher rate of low lying placenta, placenta previa, gestational diabetes and hypertensive disorders of pregnancy. CONCLUSIONS: The present study clearly shows the distribution of maternal baseline characteristics and the range of perinatal outcomes according to maternal age group. This cohort study can provide strategic information for creating breakthroughs in the pathophysiology of perinatal, developmental, and noncommunicable diseases by collaborative data visiting or sharing.

  236. 東日本大震災被災者の居住環境の変化による他者との交流習慣・メンタルヘルスへの影響

    鈴木 智美, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 中谷 直樹, 寳澤 篤, 辻 一郎, 富田 博秋

    日本公衆衛生学会総会抄録集　79回　415-415　2020/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  237. Low birth weight and abnormal pre-pregnancy body mass index were at higher risk for hypertensive disorders of pregnancy. International-journal Peer-reviewed

    Maiko Wagata, Mami Ishikuro, Taku Obara, Masato Nagai, Satoshi Mizuno, Naoki Nakaya, Tomohiro Nakamura, Takumi Hirata, Naho Tsuchiya, Hirohito Metoki, Soichi Ogishima, Atsushi Hozawa, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama, Junichi Sugawara

    Pregnancy hypertension　22　119-125　2020/10

    DOI： 10.1016/j.preghy.2020.08.001 　

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    Low birth weight is known to be associated with hypertension, cardiovascular disease and hypertensive disorders of pregnancy (HDP); however, this association might vary by race/ethnicity. This study aimed to clarify the association between women's own birth weight and their subsequent risk for HDP in a Japanese population, in combination with pre-pregnancy body mass index (BMI). We conducted a cohort study as part of the Tohoku Medical Megabank Birth and Three-Generation Cohort Study in Miyagi, Japan. Our study's population included 4810 women. A multivariate logistic regression analysis was performed to calculate the adjusted odds ratio (aOR) and the 95% confidence interval (CI) of the women's own birth weight for HDP, in the combination categories of birth weight and pre-pregnancy BMI. As a result, the group with a low birth weight of <2500 g had a significant association with HDP (the aOR, 1.50; 95% CI, 1.02-2.21). In the subtype analysis, the odds ratio for only preeclampsia was significantly increased in the low birth weight group (aOR, 3.37; 95% CI, 1.84-6.16). In the group with a low birth weight, the prevalence of HDP was higher in both the underweight and overweight groups. In conclusion, there was a significant association between low birth weight and subsequent HDP in Japanese women. Furthermore, a significant association with HDP was found for women born with a low birth weight who were underweight or overweight as adults. Maintaining a normal weight may be effective for preventing HDP even if a woman was born small.

  238. Screening for Aortic Aneurysm: Further Evidence is Required to Clarify the Issue.

    Atsushi Hozawa

    Journal of atherosclerosis and thrombosis　28　(4)　319-319　2020/09/25

    DOI： 10.5551/jat.ED143 　

  239. 本態性高血圧のリスク因子としてのナトリウム/カリウム(Na/K)比

    小暮 真奈, 田原 康玄, 寳澤 篤

    日本循環器病予防学会誌　55　(2)　114-123　2020/09

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  240. Frequency of consumption of balanced meals, bodyweight gain and incident risk of glucose intolerance in Japanese men and women: A cohort study.

    Masaru Sakurai, Masao Ishizaki, Yuko Morikawa, Teruhiko Kido, Yuchi Naruse, Yuki Nakashima, Chiaki Okamoto, Kazuhiro Nogawa, Yuuka Watanabe, Yasushi Suwazono, Atsushi Hozawa, Katsushi Yoshita, Hideaki Nakagawa

    Journal of diabetes investigation　12　(5)　763-770　2020/08/31

    DOI： 10.1111/jdi.13392 　

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    AIMS/INTRODUCTION: This cohort study assessed the risk for bodyweight gain and development of glucose intolerance based on the frequency of consumption of balanced meals including grain, fish or meat and vegetables. MATERIALS AND METHODS: The participants (8,573 men, 3,327 women) were employees of a company in Japan. A self-administered questionnaire was used to evaluate the frequency of balanced meal consumption. Bodyweight changes and the incidence of glucose intolerance (glycated hemoglobin >6.0%) during the 3-year follow-up period were determined through annual health examinations. RESULTS: The mean bodyweight change over a period of 3 years was 0.78 kg for men and 0.84 kg for women. A lower frequency of balanced meals was associated with a higher bodyweight gain for men (P for trend = 0.004), but not for women. During the study, 464 men and 115 women developed glucose intolerance. Overall, the frequency of balanced meals was not associated with the risk of glucose intolerance in either sex. However, the interaction between the frequency of balanced meals and degree of obesity had a significant effect on the incidence of glucose intolerance in men (P = 0.005), with less frequent consumption of balanced meals being associated with a higher risk for glucose intolerance among men with a BMI ≥25.0 kg/m2 (P for trend = 0.007). CONCLUSIONS: A higher frequency of balanced meals, including grain, fish or meat and vegetable dishes - important components of healthy Japanese food - was associated with a lower risk of glucose intolerance in obese men, but not in non-obese men and women.

  241. Clustering by phenotype and genome-wide association study in autism. International-journal

    Akira Narita, Masato Nagai, Satoshi Mizuno, Soichi Ogishima, Gen Tamiya, Masao Ueki, Rieko Sakurai, Satoshi Makino, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Hiroko Matsubara, Yasutaka Kuniyoshi, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomoko Kobayashi, Mika Kobayashi, Takuma Usuzaki, Hisashi Ohseto, Atsushi Hozawa, Masahiro Kikuya, Hirohito Metoki, Shigeo Kure, Shinichi Kuriyama

    Translational psychiatry　10　(1)　290-290　2020/08/17

    DOI： 10.1038/s41398-020-00951-x 　

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    Autism spectrum disorder (ASD) has phenotypically and genetically heterogeneous characteristics. A simulation study demonstrated that attempts to categorize patients with a complex disease into more homogeneous subgroups could have more power to elucidate hidden heritability. We conducted cluster analyses using the k-means algorithm with a cluster number of 15 based on phenotypic variables from the Simons Simplex Collection (SSC). As a preliminary study, we conducted a conventional genome-wide association study (GWAS) with a data set of 597 ASD cases and 370 controls. In the second step, we divided cases based on the clustering results and conducted GWAS in each of the subgroups vs controls (cluster-based GWAS). We also conducted cluster-based GWAS on another SSC data set of 712 probands and 354 controls in the replication stage. In the preliminary study, which was conducted in conventional GWAS design, we observed no significant associations. In the second step of cluster-based GWASs, we identified 65 chromosomal loci, which included 30 intragenic loci located in 21 genes and 35 intergenic loci that satisfied the threshold of P < 5.0 × 10-8. Some of these loci were located within or near previously reported candidate genes for ASD: CDH5, CNTN5, CNTNAP5, DNAH17, DPP10, DSCAM, FOXK1, GABBR2, GRIN2A5, ITPR1, NTM, SDK1, SNCA, and SRRM4. Of these 65 significant chromosomal loci, rs11064685 located within the SRRM4 gene had a significantly different distribution in the cases vs controls in the replication cohort. These findings suggest that clustering may successfully identify subgroups with relatively homogeneous disease etiologies. Further cluster validation and replication studies are warranted in larger cohorts.

  242. Machine learning for effectively avoiding overfitting is a crucial strategy for the genetic prediction of polygenic psychiatric phenotypes. International-journal Peer-reviewed

    Yuta Takahashi, Masao Ueki, Gen Tamiya, Soichi Ogishima, Kengo Kinoshita, Atsushi Hozawa, Naoko Minegishi, Fuji Nagami, Kentaro Fukumoto, Kotaro Otsuka, Kozo Tanno, Kiyomi Sakata, Atsushi Shimizu, Makoto Sasaki, Kenji Sobue, Shigeo Kure, Masayuki Yamamoto, Hiroaki Tomita

    Translational psychiatry　10　(1)　294-294　2020/08/17

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41398-020-00957-5 　

    eISSN： 2158-3188

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    The accuracy of previous genetic studies in predicting polygenic psychiatric phenotypes has been limited mainly due to the limited power in distinguishing truly susceptible variants from null variants and the resulting overfitting. A novel prediction algorithm, Smooth-Threshold Multivariate Genetic Prediction (STMGP), was applied to improve the genome-based prediction of psychiatric phenotypes by decreasing overfitting through selecting variants and building a penalized regression model. Prediction models were trained using a cohort of 3685 subjects in Miyagi prefecture and validated with an independently recruited cohort of 3048 subjects in Iwate prefecture in Japan. Genotyping was performed using HumanOmniExpressExome BeadChip Arrays. We used the target phenotype of depressive symptoms and simulated phenotypes with varying complexity and various effect-size distributions of risk alleles. The prediction accuracy and the degree of overfitting of STMGP were compared with those of state-of-the-art models (polygenic risk scores, genomic best linear-unbiased prediction, summary-data-based best linear-unbiased prediction, BayesR, and ridge regression). In the prediction of depressive symptoms, compared with the other models, STMGP showed the highest prediction accuracy with the lowest degree of overfitting, although there was no significant difference in prediction accuracy. Simulation studies suggested that STMGP has a better prediction accuracy for moderately polygenic phenotypes. Our investigations suggest the potential usefulness of STMGP for predicting polygenic psychiatric conditions while avoiding overfitting.

  243. 腹囲が生活習慣病に及ぼす影響の肥満者と非肥満者における違いの検討

    武部 典子, 丹野 高三, 長谷川 豊, 大桃 秀樹, 佐々木 亮平, 高梨 信之, 坂田 清美, 平田 匠, 寶澤 篤, 佐々木 真理, 石垣 泰

    糖尿病　63　(Suppl.1)　S-134　2020/08

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

    eISSN： 1881-588X

  244. COPD 疫学・病因・病態 出生体重と20代成人の%FEV1は相関する 東北メディカル・メガバンク機構住民健康調査に基づく呼吸機能影響因子の探索

    大江 崇, 山田 充啓, 杉浦 久敏, 布施 昇男, 寳澤 篤, 中村 智洋, 山本 雅之, 一ノ瀬 正和

    日本呼吸器学会誌　9　(増刊)　125-125　2020/08

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

    eISSN： 2186-5884

  245. 非喫煙者における家庭での受動喫煙と高血圧の関連 東北メディカル・メガバンク計画地域住民コホート調査より

    平田 匠, 小暮 真奈, 成田 暁, 土屋 菜歩, 中村 智洋, 目時 弘仁, 中谷 直樹, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    厚生の指標　67　(8)　1-8　2020/08

    Publisher: (一財)厚生労働統計協会

    ISSN： 0452-6104

  246. Genome-wide association study identifies new loci for albuminuria in the Japanese population. Peer-reviewed

    Hiroshi Okuda, Koji Okamoto, Michiaki Abe, Kota Ishizawa, Satoshi Makino, Osamu Tanabe, Junichi Sugawara, Atsushi Hozawa, Kozo Tanno, Makoto Sasaki, Gen Tamiya, Masayuki Yamamoto, Sadayoshi Ito, Tadashi Ishii

    Clinical and experimental nephrology　24　(8)　1-9　2020/08

    DOI： 10.1007/s10157-020-01884-x 　

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    BACKGROUND: Urinary albumin excretion (UAE) is a risk factor for cardiovascular diseases, metabolic syndrome, chronic kidney disease, etc. Only a few genome-wide association studies (GWAS) for UAE have been conducted in the European population, but not in the Asian population. Here we conducted GWAS and identified several candidate genes harboring single nucleotide polymorphisms (SNPs) responsible for UAE in the Japanese population. METHODS: We conducted GWAS for UAE in 7805 individuals of Asian ancestry from health-survey data collected by Tohoku Medical Megabank Organization (ToMMo) and Iwate Tohoku Medical Megabank Organization (IMM). The SNP genotype data were obtained with a SNP microarray. After imputation using a haplotype panel consisting of 2000 genome sequencing, 4,962,728 SNP markers were used for the GWAS. RESULTS: Eighteen SNPs at 14 loci (GRM7, EXOC1/NMU, LPA, STEAP1B/RAPGEF5, SEMA3D, PRKAG2, TRIQK, SERTM1, TPT1-AS1, OR5AU1, TSHR, FMN1/RYR3, COPRS, and BRD1) were associated with UAE in the Japanese individuals. A locus with particularly strong associations was observed on TSHR, chromosome 14 [rs116622332 (p = 3.99 × 10-10)]. CONCLUSION: In this study, we successfully identified UAE-associated variant loci in the Japanese population. Further study is required to confirm this association.

  247. Novel candidates of pathogenic variants of the BRCA1 and BRCA2 genes in a 3,552 Japanese whole-genome sequence dataset (3.5KJPNv2) Peer-reviewed

    Hideki Tokunaga, Keita Iida, Atsushi Hozawa, Soichi Ogishima, Yoh Watanabe, Shogo Shigeta, Muneaki Shimada, Yumi Yamaguchi-Kabata, Shu Tadaka, Fumiki Katsuoka, Shin Ito, Kazuki Kumada, Yohei Hamanaka, Nobuo Fuse, Kengo Kinoshita, Masayuki Yamamoto, Nobuo Yaegashi, Jun Yasuda

    2020/07/17

    Publisher: Cold Spring Harbor Laboratory

    DOI： 10.1101/2020.07.17.208454 　

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    <title>Abstract</title>Identification of pathogenic germline variants yet no clinical evidence in <italic>BRCA</italic> genes has become important in patient care of hereditary breast and ovarian cancer syndrome (HBOC). Computational scoring and prospective cohort studies may help to identify such pathogenic variants. We annotated the variants in the <italic>BRCA1</italic> and <italic>BRCA2</italic> genes from a dataset of 3,552 whole-genome sequences obtained from members of the genome cohorts by Tohoku Medical Megabank Project (TMM) with the InterVar software. Computational impact scores (CADD_phred and Eigen_raw) and minor allele frequencies (MAF) of pathogenic (P) and likely pathogenic (LP) variants in ClinVar are used for filtration criteria. Familial predispositions in cancers among the 35,000 TMM genome cohort participants are analyzed to verify the pathogenicity. Seven potentially pathogenic variants were newly identified. Carriers of these potential pathogenic variants and definite P and LP variants among participants of the TMM prospective cohort show a statistically significant preponderance in cancer onset in sisters in the self-reported cancer history. Filtering by computational scoring and MAF is useful to identify potential pathogenic variants in <italic>BRCA</italic> genes for Japanese population. These results will be helpful to follow up the carriers of variants of uncertain significance in the HBOC genes.

  248. The Impact of Health Consciousness on the Association Between Walking Durations and Mental Health Conditions After a Disaster: a Cross-Sectional Study. International-journal Peer-reviewed

    Yusuke Utsumi, Harumi Nemoto, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Tomomi Suzuki, Moe Seto, Mitsuaki Katayanagi, Junko Okuyama, Atsushi Sakuma, Nami Honda, Yumi Sugawara, Halley Kaye-Kauderer, Yuta Takahashi, Akemi Kayama, Yoshihisa Kakuto, Masahiro Kohzuki, Atsushi Hozawa, Ichiro Tsuji, Hiroaki Tomita

    Sports medicine - open　6　(1)　30-30　2020/07/16

    DOI： 10.1186/s40798-020-00259-6 　

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    BACKGROUND: In communities affected by a disaster, walking can be a feasible form of physical exercise to improve physical and mental health conditions. However, there is limited evidence to support relationships between walking habits and mental health conditions in post-disaster settings. Cross-sectional epidemiological data obtained from a questionnaire survey (conducted in October 2017) of a community affected by the 2011 Great East Japan Earthquake (GEJE) was analyzed to evaluate the relationships. METHODS: Participants included individuals over 20 years of age (N = 718) from Shichigahama town in Miyagi prefecture, whose houses were significantly damaged by the GEJE. Their mental health conditions were assessed by the Kessler Psychological Distress Scale (K6), the Center for Epidemiologic Studies Depression Scale (CES-D), and the Impact of Event Scale-Revised (IES-R). Additionally, the questionnaire asked the participants spent duration walking on average and their walking purpose by the following items: (1) longer than 60 min per day, (2) between 30 and 60 min per day, or (3) less than 30 min per day, and whether they walked to maintain healthy living habits (health-conscious walkers) or merely for transportation without considering health consequences (non-health-conscious walkers). These information and mental health indicators were analyzed using analysis of covariance (ANCOVA). RESULTS: Among the three walking duration groups of health-conscious walkers, there were significant differences in CES-D and K6 scores (p = 0.01 and p = 0.04), but not in IES-R scores, considering age, gender, and alcohol drinking habits as covariates. CES-D score was significantly higher among short walkers (p = 0.004). Among the three walking duration groups of non-health-conscious walkers, there were significant differences in avoidance symptoms, the subdomain of IES-R (p = 0.01), but not in CES-D, K6, and total IES-R scores, considering the variants. CONCLUSION: Our study suggests that walking durations may positively affect mood, but not PTSR, only when walking is performed with the purpose of maintaining healthy living habits. Walking durations were negatively associated with avoidance symptoms among non-health-conscious walkers in the community affected by the GEJE, indicating that the disaster may have had a long-lasting impact on walking habits.

  249. CORRIGENDUM: N-Terminal Pro-B-Type Natriuretic Peptide Is a Predictor of Chronic Kidney Disease in an Asian General Population - The Ohasama Study.

    Shingo Nakayama, Michihiro Satoh, Hirohito Metoki, Takahisa Murakami, Kei Asayama, Azusa Hara, Takuo Hirose, Ryusuke Inoue, Megumi Tsubota-Utsugi, Masahiro Kikuya, Takefumi Mori, Atsushi Hozawa, Koichi Node, Yutaka Imai, Takayoshi Ohkubo

    Circulation reports　2　(7)　384-384　2020/07/10

    DOI： 10.1253/circrep.CR-66-0006 　

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    [This corrects the article DOI: 10.1253/circrep.CR-19-0044.].

  250. 慢性腎臓病と高血圧の脳卒中発症生涯リスク 大迫研究

    中山 晋吾, 佐藤 倫広, 目時 弘仁, 村上 任尚, 浅山 敬, 原 梓, 廣瀬 卓男, 菅野 厚博, 井上 隆輔, 坪田 恵, 菊谷 昌浩, 森 建文, 寳澤 篤, 今井 潤, 大久保 孝義

    日本腎臓学会誌　62　(4)　302-302　2020/07

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  251. 糖尿病性腎症の発症・進展予測マーカーとしてのフェニル硫酸の有用性

    菊地 晃一, 三枝 大輔, 金光 祥臣, 松本 洋太郎, 三瀬 広記, 中村 智洋, 三島 英換, 豊原 敬文, 鈴木 健弘, 寳澤 篤, 和田 淳, 富岡 佳久, 阿部 高明

    日本腎臓学会誌　62　(4)　276-276　2020/07

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  252. 糖尿病性腎症の発症・進展予測マーカーとしてのフェニル硫酸の有用性

    菊地 晃一, 三枝 大輔, 金光 祥臣, 松本 洋太郎, 三瀬 広記, 中村 智洋, 三島 英換, 豊原 敬文, 鈴木 健弘, 寳澤 篤, 和田 淳, 富岡 佳久, 阿部 高明

    日本腎臓学会誌　62　(4)　276-276　2020/07

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  253. 慢性腎臓病と高血圧の脳卒中発症生涯リスク 大迫研究

    中山 晋吾, 佐藤 倫広, 目時 弘仁, 村上 任尚, 浅山 敬, 原 梓, 廣瀬 卓男, 菅野 厚博, 井上 隆輔, 坪田 恵, 菊谷 昌浩, 森 建文, 寳澤 篤, 今井 潤, 大久保 孝義

    日本腎臓学会誌　62　(4)　302-302　2020/07

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  254. Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project. Peer-reviewed

    Akito Tsuboi, Hiroyuki Matsui, Naru Shiraishi, Takahisa Murakami, Akihito Otsuki, Junko Kawashima, Tomomi Kiyama, Toru Tamahara, Maki Goto, Shihoko Koyama, Junichi Sugawara, Eiichi N Kodama, Hirohito Metoki, Atsushi Hozawa, Shinichi Kuriyama, Hiroaki Tomita, Masahiro Kikuya, Naoko Minegishi, Kichiya Suzuki, Seizo Koshiba, Gen Tamiya, Nobuo Fuse, Yuichi Aoki, Takako Takai-Igarashi, Soichi Ogishima, Tomohiro Nakamura, Mika Sakurai-Yageta, Fuji Nagami, Kengo Kinoshita, Shigeo Kure, Ritsuko Shimizu, Keiichi Sasaki, Masayuki Yamamoto

    The Tohoku journal of experimental medicine　251　(2)　97-115　2020/06

    DOI： 10.1620/tjem.251.97 　

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    In order to assess the long-term impact of the Great East Japan Earthquake on the oral health of disaster victims and to evaluate gene-environmental interactions in the development of major oral diseases and oral-systemic associations, the oral part of two large-scale genome cohort studies by the Tohoku Medical Megabank Organization (ToMMo), including the Community-based cohort (CommCohort) study and the Birth and Three-Generation cohort (BirThree) study, have been conducted. The study population comprised 32,185 subjects, including 16,886 participants in the CommCohort study and 15,299 participants in the BirThree cohort study, recruited from 2013 to 2017. The oral studies consist of a questionnaire regarding oral hygiene behavior, clinical examinations by dentists, and oral plaque and saliva sampling for microbiome analyses, which were carried out at seven community support centers in Miyagi prefecture. The median age of all participants was 55.0 years, and 66.1% of participants were women. Almost all participants reported that they brushed their teeth more than once a day. The median number of present teeth was 27.0, and the decayed, missing and filled tooth number was 16.0, with a significant difference according to age and sex. The median periodontal pocket and clinical attachment level was 2.48 mm and 4.00 mm, respectively. Periodontal parameters increased significantly according to age, except for the accumulation of dental calculus. The oral part of these extensive cross-sectional studies provides a unique and important platform for future studies on oral health and diseases that elicit through interactions with systemic diseases, lifestyles, life events and genetic backgrounds, and contributes to researches clarifying the long-term effects of disasters on oral health.

  255. Transethnic Meta-Analysis of Genome-Wide Association Studies Identifies Three New Loci and Characterizes Population-Specific Differences for Coronary Artery Disease. International-journal Peer-reviewed

    Hiroshi Matsunaga, Kaoru Ito, Masato Akiyama, Atsushi Takahashi, Satoshi Koyama, Seitaro Nomura, Hirotaka Ieki, Kouichi Ozaki, Yoshihiro Onouchi, Saori Sakaue, Shinichiro Suna, Soichi Ogishima, Masayuki Yamamoto, Atsushi Hozawa, Mamoru Satoh, Makoto Sasaki, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane, Keitaro Tanaka, Kokichi Arisawa, Hiroaki Ikezaki, Naoyuki Takashima, Mariko Naito, Kenji Wakai, Hideo Tanaka, Yasuhiko Sakata, Hiroyuki Morita, Yasushi Sakata, Koichi Matsuda, Yoshinori Murakami, Hiroshi Akazawa, Michiaki Kubo, Yoichiro Kamatani, Issei Komuro

    Circulation. Genomic and precision medicine　13　(3)　e002670　2020/06

    DOI： 10.1161/CIRCGEN.119.002670 　

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    BACKGROUND: Genome-wide association studies provided many biological insights into coronary artery disease (CAD), but these studies were mainly performed in Europeans. Genome-wide association studies in diverse populations have the potential to advance our understanding of CAD. METHODS: We conducted 2 genome-wide association studies for CAD in the Japanese population, which included 12 494 cases and 28 879 controls and 2808 cases and 7261 controls, respectively. Then, we performed transethnic meta-analysis using the results of the coronary artery disease genome-wide replication and meta-analysis plus the coronary artery disease 1000 Genomes meta-analysis with UK Biobank. We then explored the pathophysiological significance of these novel loci and examined the differences in CAD-susceptibility loci between Japanese and Europeans. RESULTS: We identified 3 new loci on chromosome 1q21 (CTSS), 10q26 (WDR11-FGFR2), and 11q22 (RDX-FDX1). Quantitative trait locus analyses suggested the association of CTSS and RDX-FDX1 with atherosclerotic immune cells. Tissue/cell type enrichment analysis showed the involvement of arteries, adrenal glands, and fat tissues in the development of CAD. We next compared the odds ratios of lead variants for myocardial infarction at 76 genome-wide significant loci in the transethnic meta-analysis and a moderate correlation between Japanese and Europeans, where 8 loci showed a difference. Finally, we performed tissue/cell type enrichment analysis using East Asian-frequent and European-frequent variants according to the risk allele frequencies and identified significant enrichment of adrenal glands in the East Asian-frequent group while the enrichment of arteries and fat tissues was found in the European-frequent group. These findings indicate biological differences in CAD susceptibility between Japanese and Europeans. CONCLUSIONS: We identified 3 new loci for CAD and highlighted the genetic differences between the Japanese and European populations. Moreover, our transethnic analyses showed both shared and unique genetic architectures between the Japanese and Europeans. While most of the underlying genetic bases for CAD are shared, further analyses in diverse populations will be needed to elucidate variations fully.

  256. Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients. International-journal

    Akiyoshi Nakayama, Masahiro Nakatochi, Yusuke Kawamura, Ken Yamamoto, Hirofumi Nakaoka, Seiko Shimizu, Toshihide Higashino, Teruhide Koyama, Asahi Hishida, Kiyonori Kuriki, Miki Watanabe, Toru Shimizu, Keiko Ooyama, Hiroshi Ooyama, Mitsuo Nagase, Yuji Hidaka, Daisuke Matsui, Takashi Tamura, Takeshi Nishiyama, Chisato Shimanoe, Sakurako Katsuura-Kamano, Naoyuki Takashima, Yuya Shirai, Makoto Kawaguchi, Mikiya Takao, Ryo Sugiyama, Yuzo Takada, Takahiro Nakamura, Hiroshi Nakashima, Masashi Tsunoda, Inaho Danjoh, Atsushi Hozawa, Kazuyoshi Hosomichi, Yu Toyoda, Yu Kubota, Tappei Takada, Hiroshi Suzuki, Blanka Stiburkova, Tanya J Major, Tony R Merriman, Nagato Kuriyama, Haruo Mikami, Toshiro Takezaki, Keitaro Matsuo, Sadao Suzuki, Tatsuo Hosoya, Yoichiro Kamatani, Michiaki Kubo, Kimiyoshi Ichida, Kenji Wakai, Ituro Inoue, Yukinori Okada, Nariyoshi Shinomiya, Hirotaka Matsuo

    Annals of the rheumatic diseases　79　(5)　657-665　2020/05

    DOI： 10.1136/annrheumdis-2019-216644 　

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    OBJECTIVES: Genome-wide meta-analyses of clinically defined gout were performed to identify subtype-specific susceptibility loci. Evaluation using selection pressure analysis with these loci was also conducted to investigate genetic risks characteristic of the Japanese population over the last 2000-3000 years. METHODS: Two genome-wide association studies (GWASs) of 3053 clinically defined gout cases and 4554 controls from Japanese males were performed using the Japonica Array and Illumina Array platforms. About 7.2 million single-nucleotide polymorphisms were meta-analysed after imputation. Patients were then divided into four clinical subtypes (the renal underexcretion type, renal overload type, combined type and normal type), and meta-analyses were conducted in the same manner. Selection pressure analyses using singleton density score were also performed on each subtype. RESULTS: In addition to the eight loci we reported previously, two novel loci, PIBF1 and ACSM2B, were identified at a genome-wide significance level (p<5.0×10-8) from a GWAS meta-analysis of all gout patients, and other two novel intergenic loci, CD2-PTGFRN and SLC28A3-NTRK2, from normal type gout patients. Subtype-dependent patterns of Manhattan plots were observed with subtype GWASs of gout patients, indicating that these subtype-specific loci suggest differences in pathophysiology along patients' gout subtypes. Selection pressure analysis revealed significant enrichment of selection pressure on ABCG2 in addition to ALDH2 loci for all subtypes except for normal type gout. CONCLUSIONS: Our findings on subtype GWAS meta-analyses and selection pressure analysis of gout will assist elucidation of the subtype-dependent molecular targets and evolutionary involvement among genotype, phenotype and subtype-specific tailor-made medicine/prevention of gout and hyperuricaemia.

  257. Association of serum adiponectin levels and body mass index with worsening depressive symptoms in elderly individuals: a 10-year longitudinal study. International-journal Peer-reviewed

    Cong Huang, Mana Kogure, Yasutake Tomata, Yumi Sugawara, Atsushi Hozawa, Haruki Momma, Ichiro Tsuji, Ryoichi Nagatomi

    Aging & mental health　24　(5)　725-731　2020/05

    DOI： 10.1080/13607863.2019.1584877 　

    ISSN： 1360-7863

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    Objectives: Data regarding the association between adiponectin levels and body mass index (BMI) and long-term changes in depressive symptoms are limited and inconsistent. Thus, we investigated whether circulating adiponectin levels and BMI were independently and combinedly correlated to longitudinal changes in depressive symptoms.Methods: This prospective cohort study evaluated 269 elderly Japanese individuals aged ≥70 years who participated in the Tsurugaya Project conducted between 2002 and 2012. A short form of the Geriatric Depression Scale (GDS) was used to assess depressive status. Serum adiponectin levels were measured using an enzyme-linked immunosorbent assay or a latex particle-enhanced turbidimetric immunoassay. BMI was calculated as body weight (kg)/height (m2).Results: Multiple linear regression analysis revealed that baseline serum adiponectin levels were positively associated with changes in GDS scores (β = 0.14, P = 0.035). However, no association was observed after adjusting for BMI (β = 0.09, P = 0.185). Low BMI was associated with increased GDS scores at the 10-year follow-up (β = -0.14, P = 0.033). Participants with a combination of high adiponectin levels and low BMI had a 3.3-fold higher risk of worsening depressive symptoms than those with low adiponectin levels and high BMI (odds ratio: 3.35, 95% confidence interval: 1.60-7.00; P = 0.001).Conclusions: This longitudinal study indicated that high serum adiponectin levels and low BMI were both associated with worsening depressive symptoms among older Japanese individuals. Furthermore, the combination of high adiponectin levels and low BMI was associated with worsening depressive symptoms.

  258. 東北メディカル・メガバンク機構-地域住民コホート調査の進捗について

    寳澤 篤, 土屋 菜歩, 平田 匠, 小暮 真奈, 成田 暁, 中村 智洋, 中谷 直樹, 小原 拓, 栗山 進一, 菅原 準一, 呉 繁夫

    宮城県公衆衛生学会会誌　(52)　20-20　2020/04

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  259. 抗炎症作用を有する食事と高次生活機能低下との関連 大迫研究

    佐藤 桂子, 今井 絵理, 坪田 恵[宇津木], 佐藤 倫広, 村上 任尚, 辰巳 友佳子, 井上 隆輔, 浅山 敬, 菊谷 昌浩, 野村 恭子, 目時 弘仁, 寶澤 篤, 今井 潤, 大久保 孝義

    日本栄養・食糧学会大会講演要旨集　74回　240-240　2020/04

    Publisher: (公社)日本栄養・食糧学会

  260. 抗炎症作用を有する食事と高次生活機能低下との関連 大迫研究

    佐藤 桂子, 今井 絵理, 坪田 恵[宇津木], 佐藤 倫広, 村上 任尚, 辰巳 友佳子, 井上 隆輔, 浅山 敬, 菊谷 昌浩, 野村 恭子, 目時 弘仁, 寶澤 篤, 今井 潤, 大久保 孝義

    日本栄養・食糧学会大会講演要旨集　74回　240-240　2020/04

    Publisher: (公社)日本栄養・食糧学会

  261. 東北メディカル・メガバンク機構-地域住民コホート調査の進捗について

    寳澤 篤, 土屋 菜歩, 平田 匠, 小暮 真奈, 成田 暁, 中村 智洋, 中谷 直樹, 小原 拓, 栗山 進一, 菅原 準一, 呉 繁夫

    宮城県公衆衛生学会会誌　(52)　20-20　2020/04

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  262. Public Relations and Communication Strategies in Construction of Large-Scale Cohorts and Biobank: Practice in the Tohoku Medical Megabank Project.

    Fuji Nagami, Miho Kuriki, Sachie Koreeda, Maiko Kageyama, Osamu Shimizu, Soichiro Toda, Atsushi Hozawa, Shinichi Kuriyama, Noriko Osumi, Masayuki Yamamoto

    The Tohoku journal of experimental medicine　250　(4)　253-262　2020/04

    DOI： 10.1620/tjem.250.253 　

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    The Tohoku Medical Megabank Project was designed as part of the national reconstruction project for addressing the damage from the 2011 Great East Japan Earthquake. It is an integrated project involving the genome cohort study of 150,000 participants, integrated biobank construction, and multi-omics analyses. Public relations and communication activities emerged to be extremely important in the successful development of this project. To gain insights into the contributions of these activities, we divided the public relations and communication activities for the project into three phases based on the situations surrounding the project. Prior to the start of the cohort study (Phase I), a cooperative relationship was established with a focus on concluding cooperation agreements with local governments. Until the participants reached the target number (Phase II), we actively communicated with the media to publicize the project. During the phase in which use of the constructed biobank is promoted (Phase III), for ensuring the industrial utilization of the biobank, visits from the industry are promoted. Throughout the execution of these activities, we explored the best strategies for building relationships with multiple stakeholders like local government, media and industry. By paying attention to these phases that have been changing according to the project's progress, we were able to adapt the strategies and methods of public relations and communication. The success of these activities has enabled the overall project to progress smoothly. We hope that the process of designing our project's public relations and communication activities will be useful for other similar initiatives.

  263. Author Correction: Characterizing rare and low-frequency height-associated variants in the Japanese population. International-journal Peer-reviewed

    Masato Akiyama, Kazuyoshi Ishigaki, Saori Sakaue, Yukihide Momozawa, Momoko Horikoshi, Makoto Hirata, Koichi Matsuda, Shiro Ikegawa, Atsushi Takahashi, Masahiro Kanai, Sadao Suzuki, Daisuke Matsui, Mariko Naito, Taiki Yamaji, Motoki Iwasaki, Norie Sawada, Kozo Tanno, Makoto Sasaki, Atsushi Hozawa, Naoko Minegishi, Kenji Wakai, Shoichiro Tsugane, Atsushi Shimizu, Masayuki Yamamoto, Yukinori Okada, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani

    Nature communications　11　(1)　1350-1350　2020/03/09

    DOI： 10.1038/s41467-020-15202-2 　

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    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

  264. Living Arrangement Affects Urine Na/k Ratio Among 44,085 Residents: Tohoku Medical Megabank Project Community-based Cohort Study Peer-reviewed

    Takahiro Mikami, Kozo Tanno, Ryouhei Sasaki, Nobuyuki Takanashi, Yuka Kotozaki, Mana Kogure, Atsushi Hozawa, Kiyomi Sakata, Makoto Sasaki

    Circulation　141　(Suppl_1)　2020/03/03

    DOI： 10.1161/circ.141.suppl_1.p483 　

    ISSN： 0009-7322

    eISSN： 1524-4539

  265. The Association Between Social Isolation and Metabolic Syndrome in Japanese Adults: The Tohoku Medical Megabank Project Peer-reviewed

    Yuka Kotozaki, Kozo Tanno, Kotaro Otsuka, Ryouhei Sasaki, Nobuyuki Takanashi, Takahiro Mikami, Tomohiro Nakamura, Atsushi Hozawa, Koichi Asahi, Mamoru Satoh, Atsushi Shimizu, Yasushi Ishigaki, Kiyomi Sakata, Makoto Sasaki

    Circulation　141　(Suppl_1)　2020/03/03

    DOI： 10.1161/circ.141.suppl_1.p539 　

    ISSN： 0009-7322

    eISSN： 1524-4539

  266. Food sources of dietary potassium in the adult Japanese population: The international study of macro-/micronutrients and blood pressure (INTERMAP)

    Nagako Okuda, Akira Okayama, Katsuyuki Miura, Katsushi Yoshita, Naoko Miyagawa, Shigeyuki Saitoh, Hideaki Nakagawa, Kiyomi Sakata, Queenie Chan, Paul Elliott, Hirotsugu Ueshima, Jeremiah Stamler, INTERMAP Research Group

    Nutrients　12　(3)　2020/03/01

    Publisher: MDPI AG

    DOI： 10.3390/nu12030787 　

    ISSN： 2072-6643

  267. 重度歯周病罹患歯の保有数と血圧との関連 大迫研究

    村上 任尚, 佐藤 倫広, 小宮山 貴将, 大井 孝, 遠藤 耕生, 平塚 貴子, 浅山 敬, 菊谷 昌浩, 井上 隆輔, 坪田 恵, 目時 弘仁, 寳澤 篤, 今井 潤, 服部 佳功, 大久保 孝義

    日本衛生学雑誌　75　(Suppl.)　S161-S161　2020/03

    Publisher: (一社)日本衛生学会

    ISSN： 0021-5082

    eISSN： 1882-6482

  268. 重度歯周病罹患歯の保有数と血圧との関連 大迫研究 Peer-reviewed

    村上 任尚, 佐藤 倫広, 小宮山 貴将, 大井 孝, 遠藤 耕生, 平塚 貴子, 浅山 敬, 菊谷 昌浩, 井上 隆輔, 坪田 恵, 目時 弘仁, 寳澤 篤, 今井 潤, 服部 佳功, 大久保 孝義

    日本衛生学雑誌　75　(Suppl.)　S161-S161　2020/03

    Publisher: (一社)日本衛生学会

    ISSN： 0021-5082

    eISSN： 1882-6482

  269. Relationship between calcium intake and impaired activities of daily living in a Japanese population: NIPPON DATA90. Peer-reviewed

    Mana Kogure, Naho Tsuchiya, Akira Narita, Takumi Hirata, Naoki Nakaya, Tomohiro Nakamura, Atsushi Hozawa, Takehito Hayakawa, Nagako Okuda, Naoko Miyagawa, Aya Kadota, Takayoshi Ohkubo, Yoshitaka Murakami, Kiyomi Sakata, Katsuyuki Miura, Akira Okayama, Tomonori Okamura, Hirotsugu Ueshima

    Journal of epidemiology　31　(2)　119-124　2020/02/08

    DOI： 10.2188/jea.JE20190234 　

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    BACKGROUND: Major reasons for long-term care insurance certification in Japan are stroke, dementia and fracture. These diseases are reported to be associated with calcium intake. This study examined the association between calcium intake and impaired activities of daily living (ADL) using the data from NIPPON DATA90, consisting of representative sample of the Japanese population. METHODS: A population-based nested case control study was performed. A baseline survey was conducted in 1990, followed by ADL surveys of individuals ≥65 years old in 2000. Individuals with impaired ADL and selected age- and sex-matched controls were then identified. We obtained 132 pairs. Calcium intake was energy-adjusted using the residual method. The association between calcium intake and impaired ADL was examined using conditional logistic regression models. To assess the accuracy of the estimates, we conducted bootstrap analyses. RESULTS: The adjusted odds ratios (ORs) for impaired ADL compared with the group with a calcium intake of <476 mg/day were 0.72 (95% confidence interval, 95% CI: 0.37-1.40) for the 476-606 mg/day group and 0.44 (0.21-0.94) for the ≥607 mg/day group in 2000 (P for linear trend = 0.03). After the bootstrap analyses, the inverse relationship unchanged (median OR per 100-mg rise in calcium intake: 0.87 [1,000 resamplings], 95% CI: 0.76-0.97). CONCLUSIONS: After bootstrap analyses, calcium intake was inversely associated with impaired ADL, 10 years after the baseline survey.

  270. 糖尿病による推定糸球体濾過量(eGFR)の季節差

    良知 弘務, 土屋 菜歩, 平田 匠, 中村 智洋, 栗山 進一, 菅原 準一, 辻 一郎, 呉 繁夫, 宮崎 真理子, 寳澤 篤

    日本内分泌学会雑誌　95　(4)　1606-1606　2020/02

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  271. フェニル硫酸は糖尿病性腎症におけるアルブミン尿増悪の新たな原因物質である

    菊地 晃一, 三枝 大輔, 金光 祥臣, 松本 洋太郎, 三瀬 広記, 鈴木 健弘, 寳澤 篤, 和田 淳, 富岡 佳久, 阿部 高明

    日本内分泌学会雑誌　95　(4)　1620-1620　2020/02

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  272. Relationship of household salt intake level with long-term all-cause and cardiovascular disease mortality in Japan: NIPPON DATA80. International-journal Peer-reviewed

    Azusa Shima, Naomi Miyamatsu, Katsuyuki Miura, Naoko Miyagawa, Nagako Okuda, Katsushi Yoshita, Aya Kadota, Harumitsu Suzuki, Keiko Kondo, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima

    Hypertension research : official journal of the Japanese Society of Hypertension　43　(2)　132-139　2020/02

    DOI： 10.1038/s41440-019-0349-9 　

    ISSN： 0916-9636

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    In Asian countries, a major source of salt intake is from seasoning or table salt added at home. However, little is known about the adverse effects of salt intake evaluated according to household unit. We investigated the relationship between household salt intake level and mortality from all-cause and cardiovascular diseases (CVDs). Participants included 8702 individuals (56% women) who were living with someone else and who were aged 30-79 years and enrolled in the National Nutritional Survey of Japan in 1980 with a 24-year follow-up. Household nutrient intake was evaluated using a 3-day weighing record method in which all foods and beverages consumed by any of the household members were recorded. The household salt intake level was defined as the amount of salt consumed (g) per 1000 kcal of total energy intake in each household, and its average was 6.25 (2.02) g/1000 kcal. During the follow-up, there were 2360 deaths (787 CVD, 168 coronary heart disease [CHD], and 361 stroke). Cox proportional hazard ratios (HRs) for an increment of 2 g/1000 kcal in household salt intake were calculated and adjusting for sex, age, body mass index, smoking status, alcohol consumption status, self-reported work exertion level, household potassium intake, household saturated fatty acid intake, and household long-chain n-3 polyunsaturated fatty acid intake. The HRs (95% confidence intervals) were 1.07 (1.02, 1.12) for all-cause mortality, 1.11 (1.03, 1.19) for CVD, 1.25 (1.08, 1.44) for CHD, and 1.12 (1.00, 1.25) for stroke. The household salt intake level was significantly associated with long-term risk of all-cause, CVD, CHD, and stroke mortality in a representative Japanese population.

  273. Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective. International-journal Peer-reviewed

    Shinichi Kuriyama, Hirohito Metoki, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Masato Nagai, Hiroko Matsubara, Tomoko Kobayashi, Junichi Sugawara, Gen Tamiya, Atsushi Hozawa, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Takumi Hirata, Ichiro Tsuji, Fuji Nagami, Nobuo Fuse, Tomohiko Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Yoichi Suzuki, Noriko Osumi, Keiko Nakayama, Kiyoshi Ito, Shinichi Egawa, Koichi Chida, Eiichi Kodama, Hideyasu Kiyomoto, Tadashi Ishii, Akito Tsuboi, Hiroaki Tomita, Yasuyuki Taki, Hiroshi Kawame, Kichiya Suzuki, Naoto Ishii, Soichi Ogishima, Satoshi Mizuno, Takako Takai-Igarashi, Naoko Minegishi, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Osamu Tanabe, Seizo Koshiba, Hiroaki Hashizume, Hozumi Motohashi, Teiji Tominaga, Sadayoshi Ito, Kozo Tanno, Kiyomi Sakata, Atsushi Shimizu, Jiro Hitomi, Makoto Sasaki, Kengo Kinoshita, Hiroshi Tanaka, Tadao Kobayashi, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto

    International journal of epidemiology　49　(1)　18-19　2020/02/01

    DOI： 10.1093/ije/dyz169 　

    ISSN： 0300-5771

  274. Study profile of The Tohoku Medical Megabank Community-Based Cohort Study. Peer-reviewed

    Atsushi Hozawa, Kozo Tanno, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Akira Narita, Mana Kogure, Kotaro Nochioka, Ryohei Sasaki, Nobuyuki Takanashi, Kotaro Otsuka, Kiyomi Sakata, Shinichi Kuriyama, Masahiro Kikuya, Osamu Tanabe, Junichi Sugawara, Kichiya Suzuki, Yoichi Suzuki, Eiichi N Kodama, Nobuo Fuse, Hideyasu Kiyomoto, Hiroaki Tomita, Akira Uruno, Yohei Hamanaka, Hirohito Metoki, Mami Ishikuro, Taku Obara, Tomoko Kobayashi, Kazuyuki Kitatani, Takako Takai-Igarashi, Soichi Ogishima, Mamoru Satoh, Hideki Ohmomo, Akito Tsuboi, Shinichi Egawa, Tadashi Ishii, Kiyoshi Ito, Sadayoshi Ito, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Masao Nagasaki, Kazuhiko Igarashi, Seizo Koshiba, Ritsuko Shimizu, Gen Tamiya, Keiko Nakayama, Hozumi Motohashi, Jun Yasuda, Atsushi Shimizu, Tsuyoshi Hachiya, Yuh Shiwa, Teiji Tominaga, Hiroshi Tanaka, Kotaro Oyama, Ryoichi Tanaka, Hiroshi Kawame, Akimune Fukushima, Yasushi Ishigaki, Tomoharu Tokutomi, Noriko Osumi, Tadao Kobayashi, Fuji Nagami, Hiroaki Hashizume, Tomohiro Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Ryujin Endo, Satoshi Nishizuka, Ichiro Tsuji, Jiro Hitomi, Motoyuki Nakamura, Kuniaki Ogasawara, Nobuo Yaegashi, Kengo Kinoshita, Shigeo Kure, Akio Sakai, Seiichiro Kobayashi, Kenji Sobue, Makoto Sasaki, Masayuki Yamamoto

    Journal of epidemiology　31　(1)　65-76　2020/01/11

    DOI： 10.2188/jea.JE20190271 　

    ISSN： 0917-5040

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    BackgroundWe established a community-based cohort study to assess the long-term impact of the Great East Japan Earthquake on disaster victims and gene-environmental interactions on the incidence of major diseases such as cancer and cardiovascular diseases.MethodsWe asked participants to join our cohort in the health check-up settings and assessment center based settings. Inclusion criteria was aged 20 years or over and living in Miyagi or Iwate Prefecture. We obtained information on lifestyle, effect of disaster, blood, and urine information (Type 1 survey), and some detailed measurements (Type 2 survey), for example, carotid echography, calcaneal ultrasound bone mineral density, and so on. All participants agreed to measure genome information and to distribute their information widely.ResultsAs a result, 87,865 gave their informed consent to join our study. Participation rate at health check-up site was about 70%. The participants with Type 1 survey were more likely to have psychological distress than those of Type 2 survey, and women were more likely to have psychological distress than men. Additionally, coastal residents were more likely to have higher degrees of psychological distress than inland residents regardless of sex.ConclusionThis cohort comprised large sample size and it contains information on disaster, genome information, and metabolome information. This cohort also had several detailed measurements. Using this cohort enabled us to clarify the long-term effect of disaster and also to establish personalized prevention based on genome, metabolome, and other omics information.

  275. Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project. International-journal

    Sakae Saito, Yuichi Aoki, Toru Tamahara, Maki Goto, Hiroyuki Matsui, Junko Kawashima, Inaho Danjoh, Atsushi Hozawa, Shinichi Kuriyama, Yoichi Suzuki, Nobuo Fuse, Shigeo Kure, Riu Yamashita, Osamu Tanabe, Naoko Minegishi, Kengo Kinoshita, Akito Tsuboi, Ritsuko Shimizu, Masayuki Yamamoto

    Frontiers in cellular and infection microbiology　10　604596-604596　2020

    DOI： 10.3389/fcimb.2020.604596 　

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    A baseline oral microbiome study of the Tohoku Medical Megabank Organization (TMM) was planned to characterize the profile of the oral microbiome in the Japanese population. The study also aimed to clarify risk factors for multifactorial diseases by integrated analysis of the oral microbiome and host genome/omics information. From 2013 to 2016, we collected three types of oral biospecimens, saliva, supragingival plaque, and tongue swab, from a total of 25,101 participants who had a dental examination in TMM. In this study, we used two independent cohorts; the Community-Based Cohort and Birth and Three-Generation Cohort as discovery and validation cohorts, respectively, and we selected participants examined by a single dentist. We found through the 16S ribosomal RNA gene sequencing analysis of 834 participants of the Community-Based Cohort Study that there are differences in the microbial composition and community structure between saliva and plaque. The species diversities in both saliva and plaque were increased in correlation with the severity of periodontal disease. These results were nicely reproduced in the analysis of 455 participants of the Birth and Three-Generation Cohort Study. In addition, strong positive and negative associations of microbial taxa in both plaque and saliva with periodontitis-associated biofilm formation were detected by co-occurrence network analysis. The classes Actinobacteria and Bacilli, including oral health-associated bacterial species, showed a positive correlation in saliva. These results revealed differences in microbial composition and community structure between saliva and plaque and a correlation between microbial species and the severity of periodontal disease. We expect that the large database of the oral microbiome in the TMM biobank will help in the discovery of novel targets for the treatment and prevention of oral diseases, as well as for the discovery of therapeutic and/or preventive targets of systemic diseases.

  276. N-Terminal Pro-B-Type Natriuretic Peptide Is a Predictor of Chronic Kidney Disease in an Asian General Population - The Ohasama Study.

    Shingo Nakayama, Michihiro Satoh, Hirohito Metoki, Takahisa Murakami, Kei Asayama, Azusa Hara, Takuo Hirose, Ryusuke Inoue, Megumi Tsubota-Utsugi, Masahiro Kikuya, Takefumi Mori, Atsushi Hozawa, Koichi Node, Yutaka Imai, Takayoshi Ohkubo

    Circulation reports　2　(1)　24-32　2019/12/11

    DOI： 10.1253/circrep.CR-19-0044 　

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    Background: N-terminal pro-B-type natriuretic peptide (NT-proBNP) is known to increase in heart failure patients. Given that no reports have described the association between NT-proBNP and chronic kidney disease (CKD) incidence in Asian populations, we investigated this association in the Japanese population. Methods and Results: We followed up 867 participants without CKD from the general population of Ohasama, Japan. We defined CKD as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 and/or proteinuria. In accordance with previous studies, the participants were classified into 4 groups according to NT-proBNP level (<30.0, 30.0-54.9, 55.0-124.9, and ≥125.0 pg/mL). The Cox model was applied to assess adjusted hazard ratios (HR) for CKD incidence after full adjustment including baseline eGFR. Participant mean age was 59.1 years, and 587 (67.7%) were women. During the mean follow-up period of 9.7 years, 177 participants developed CKD. When the group with NT-proBNP <30.0 pg/mL was used as the reference, adjusted HR for CKD incidence in the 30.0-54.9, 55.0-124.9, and ≥125.0 pg/mL groups were 1.34 (95% CI: 0.90-2.01), 1.25 (95% CI: 0.81-1.92), and 1.83 (95% CI: 1.05-3.18), respectively. Conclusions: NT-proBNP can be significantly predictive for CKD incidence in Asian populations.

  277. Association Between Body Mass Index and All-Cause Death in Japanese Population: Pooled Individual Participant Data Analysis of 13 Cohort Studies. Peer-reviewed

    Atsushi Hozawa, Takumi Hirata, Hiroshi Yatsuya, Yoshitaka Murakami, Shinichi Kuriyama, Ichiro Tsuji, Daisuke Sugiyama, Atsushi Satoh, Sachiko Tanaka-Mizuno, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura

    Journal of epidemiology　29　(12)　457-463　2019/12/05

    DOI： 10.2188/jea.JE20180124 　

    ISSN： 0917-5040

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    BACKGROUND: We sought to investigate the optimal values of BMI for the lowest risk of all-cause death and whether the optimal BMI differs according to smoking status in large-scale pooled analysis of 13 Japanese cohorts. METHODS: Data from 179,987 participants of 13 well-qualified cohort studies conducted throughout Japan were used for our analysis. A cohort-stratified Cox proportional hazard model was used. P values for interactions were calculated based on the cross product of BMI and age, sex, or smoking status. RESULTS: In the entire study population, all-cause mortality risk was lowest when the BMI was 22.0-24.9 kg/m2. This was also the case for selected healthy participants (never smoked, baseline total cholesterol level ≥4.1 mmol/L; the first 5 years of follow-up data were excluded). No effect modification of age, sex, or smoking status was observed. Regardless of their BMI, never smokers always had a lower all-cause mortality risk than did current smokers even with an ideal BMI in terms of mortality risk. CONCLUSION: A BMI of 22-24.9 kg/m2 correlated with the lowest risk of mortality, regardless of whether all participants or selected healthy participants were analyzed. The fact that smoking was more strongly associated with mortality than obesity emphasizes the urgency for effective anti-smoking programs.

  278. Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease International-journal Peer-reviewed

    Koichi Kikuchi, Daisuke Saigusa, Yoshitomi Kanemitsu, Yotaro Matsumoto, Paxton Thanai, Naoto Suzuki, Koki Mise, Hiroaki Yamaguchi, Tomohiro Nakamura, Kei Asaji, Chikahisa Mukawa, Hiroki Tsukamoto, Toshihiro Sato, Yoshitsugu Oikawa, Tomoyuki Iwasaki, Yuji Oe, Tomoya Tsukimi, Noriko N. Fukuda, Hsin-Jung HO, Fumika Nanto-Hara, Jiro Ogura, Ritsumi Saito, Shizuko Nagao, Yusuke Ohsaki, Satoshi Shimada, Takehiro Suzuki, Takafumi Toyohara, Eikan Mishima, Hisato Shima, Yasutoshi Akiyama, Yukako Akiyama, Mariko Ichijo, Tetsuro Matsuhashi, Akihiro Matsuo, Yoshiaki Ogata, Ching-Chin Yang, Chitose Suzuki, Matthew C. Breeggemann, Jurgen Heymann, Miho Shimizu, Susumu Ogawa, Nobuyuki Takahashi, Takashi Suzuki, Yuji Owada, Shigeo Kure, Nariyasu Mano, Tomoyoshi Soga, Takashi Wada, Jeffrey B. Kopp, Shinji Fukuda, Atsushi Hozawa, Masayuki Yamamoto, Sadayoshi Ito, Jun Wada, Yoshihisa Tomioka, Takaaki Abe

    Nature Communications　10　(1)　1835-1835　2019/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41467-019-09735-4 　

    eISSN： 2041-1723

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    Diabetic kidney disease is a major cause of renal failure that urgently necessitates a breakthrough in disease management. Here we show using untargeted metabolomics that levels of phenyl sulfate, a gut microbiota-derived metabolite, increase with the progression of diabetes in rats overexpressing human uremic toxin transporter SLCO4C1 in the kidney, and are decreased in rats with limited proteinuria. In experimental models of diabetes, phenyl sulfate administration induces albuminuria and podocyte damage. In a diabetic patient cohort, phenyl sulfate levels significantly correlate with basal and predicted 2-year progression of albuminuria in patients with microalbuminuria. Inhibition of tyrosine phenol-lyase, a bacterial enzyme responsible for the synthesis of phenol from dietary tyrosine before it is metabolized into phenyl sulfate in the liver, reduces albuminuria in diabetic mice. Together, our results suggest that phenyl sulfate contributes to albuminuria and could be used as a disease marker and future therapeutic target in diabetic kidney disease.

  279. Construction of JRG (Japanese reference genome) with single-molecule real-time sequencing International-journal

    Masao Nagasaki, Yoko Kuroki, Tomoko F. Shibata, Fumiki Katsuoka, Takahiro Mimori, Yosuke Kawai, Naoko Minegishi, Atsushi Hozawa, Shinichi Kuriyama, Yoichi Suzuki, Hiroshi Kawame, Fuji Nagami, Takako Takai-Igarashi, Soichi Ogishima, Kaname Kojima, Kazuharu Misawa, Osamu Tanabe, Nobuo Fuse, Hiroshi Tanaka, Nobuo Yaegashi, Kengo Kinoshita, Shiego Kure, Jun Yasuda, Masayuki Yamamoto

    Human Genome Variation　6　27-27　2019/12/01

    DOI： 10.1038/s41439-019-0057-7 　

    eISSN： 2054-345X

  280. Opposing Age-Related Trends in Absolute and Relative Risk of Adverse Health Outcomes Associated With Out-of-Office Blood Pressure. International-journal Peer-reviewed

    Yan Li, Lutgarde Thijs, Zhen-Yu Zhang, Kei Asayama, Tine W Hansen, José Boggia, Kristina Björklund-Bodegård, Wen-Yi Yang, Teemu J Niiranen, Angeliki Ntineri, Fang-Fei Wei, Masahiro Kikuya, Takayoshi Ohkubo, Eamon Dolan, Atsushi Hozawa, Ichiro Tsuji, Katarzyna Stolarz-Skrzypek, Qi-Fang Huang, Jesus D Melgarejo, Valérie Tikhonoff, Sofia Malyutina, Edoardo Casiglia, Yuri Nikitin, Lars Lind, Edgardo Sandoya, Lucas Aparicio, Jessica Barochiner, Natasza Gilis-Malinowska, Krzysztof Narkiewicz, Kalina Kawecka-Jaszcz, Gladys E Maestre, Antti M Jula, Jouni K Johansson, Tatiana Kuznetsova, Jan Filipovský, George Stergiou, Ji-Guang Wang, Yutaka Imai, Eoin O'Brien, Jan A Staessen

    Hypertension (Dallas, Tex. : 1979)　74　(6)　1333-1342　2019/12

    DOI： 10.1161/HYPERTENSIONAHA.119.12958 　

    ISSN： 0194-911X

  281. TMM計画地域住民コホート調査(宮城)調査票項目と総死亡の関連

    寳澤 篤, 土屋 菜歩, 平田 匠, 成田 暁, 小暮 真奈, 中村 智洋, 小原 拓, 中谷 直樹, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 布施 昇男, 山本 雅之

    日本公衆衛生学会総会抄録集　78回　212-212　2019/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  282. 6.3万人データ分譲に向けて 東北メディカル・メガバンク計画地域住民コホート調査

    土屋 菜歩, 中村 智洋, 平田 匠, 成田 暁, 小暮 真奈, 村上 慶子, 小原 拓, 中谷 直樹, 丹野 高三, 坂田 清美, 菅原 準一, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集　78回　212-212　2019/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  283. 遺伝因子と飲酒量の交互作用と随時血圧値の関連 東北メディカル・メガバンク事業

    成田 暁, 中谷 直樹, 小暮 真奈, 田宮 元, 中村 智洋, 土屋 菜歩, 平田 匠, 丹野 高三, 清水 厚志, 菅原 準一, 栗山 進一, 辻 一郎, 木下 賢吾, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　78回　216-216　2019/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  284. 睡眠の測定機器から得られた睡眠状況と心理的苦痛との関連

    五十嵐 有香, 小暮 真奈, 中村 智洋, 土屋 菜歩, 平田 匠, 成田 暁, 宮川 健, 宇留野 晃, 中谷 直樹, 菅原 準一, 栗山 進一, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　78回　223-223　2019/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  285. 家庭での受動喫煙および能動喫煙の組み合わせと高血圧の関連

    平田 匠, 小暮 真奈, 成田 暁, 土屋 菜歩, 中村 智洋, 目時 弘仁, 中谷 直樹, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　78回　223-223　2019/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  286. 高血圧有病率からみた尿ナトカリ比の目標値と必要測定回数の検討 東北メディカル・メガバンク計画コホート調査の成果から

    小暮 真奈, 平田 匠, 土屋 菜歩, 中村 智洋, 宮川 健, 小清水 宏, 小原 拓, 目時 弘仁, 宇留野 晃, 菊谷 昌浩, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　42回　287-287　2019/10

    Publisher: (NPO)日本高血圧学会

  287. 特定健康診査時に尿ナトカリ計で2年連続測定した尿ナトリウム/カリウム比の変化と血圧への影響 COI東北拠点と宮城県登米市の共同研究

    小暮 真奈, 須藤 庸子, 中村 智洋, 土屋 菜歩, 平田 匠, 成田 暁, 宮川 健, 中谷 直樹, 佐々木 秀美, 本間 洋子, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　42回　287-287　2019/10

    Publisher: (NPO)日本高血圧学会

  288. 非喫煙者における受動喫煙の有無と家庭高血圧の関連

    平田 匠, 小暮 真奈, 成田 暁, 佐藤 倫広, 土屋 菜歩, 中村 智洋, 宇留野 晃, 小原 拓, 目時 弘仁, 中谷 直樹, 菅原 準一, 栗山 進一, 呉 繁夫, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　42回　288-288　2019/10

    Publisher: (NPO)日本高血圧学会

  289. 血漿メタボロームと頸動脈内膜中膜肥厚の関連

    寳澤 篤, 小柴 生造, 平田 匠, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 元池 育子, 三枝 大輔, 峯岸 直子, 栗山 進一, 田宮 元, 辻 一郎, 木下 賢吾, 呉 繁夫

    日本高血圧学会総会プログラム・抄録集　42回　304-304　2019/10

    Publisher: (NPO)日本高血圧学会

  290. 配偶者同士の生活習慣の一致性とその年齢の影響 ToMMo 地域住民コホート調査 Peer-reviewed

    中谷 直樹, 土屋 菜歩, 成田 暁, 石黒 真美, 目時 弘仁, 平田 匠, 小暮 真奈, 中村 智洋, 後岡 広太郎, 中谷 久美, 辻 一郎, 呉 繁夫, 栗山 進一, 寳澤 篤

    日本公衆衛生学会総会抄録集　78回　224-224　2019/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  291. 東日本大震災後の仕事の変化によるメンタルヘルスの経年変化 TMM CommCohort Study Peer-reviewed

    高梨 信之, 丹野 高三, 佐々木 亮平, 事崎 由佳, 三上 貴浩, 寳澤 篤, 坪田 恵, 田鎖 愛理, 大塚 耕太郎, 清水 厚志, 坂田 清美

    日本公衆衛生学会総会抄録集　78回　241-241　2019/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  292. TMM計画地域住民コホート調査(宮城)調査票項目と総死亡の関連 Peer-reviewed

    寳澤 篤, 土屋 菜歩, 平田 匠, 成田 暁, 小暮 真奈, 中村 智洋, 小原 拓, 中谷 直樹, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 布施 昇男, 山本 雅之

    日本公衆衛生学会総会抄録集　78回　212-212　2019/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  293. 6.3万人データ分譲に向けて 東北メディカル・メガバンク計画地域住民コホート調査 Peer-reviewed

    土屋 菜歩, 中村 智洋, 平田 匠, 成田 暁, 小暮 真奈, 村上 慶子, 小原 拓, 中谷 直樹, 丹野 高三, 坂田 清美, 菅原 準一, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集　78回　212-212　2019/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  294. 高血圧有病率からみた尿ナトカリ比の目標値と必要測定回数の検討 東北メディカル・メガバンク計画コホート調査の成果から Peer-reviewed

    小暮 真奈, 平田 匠, 土屋 菜歩, 中村 智洋, 宮川 健, 小清水 宏, 小原 拓, 目時 弘仁, 宇留野 晃, 菊谷 昌浩, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　42回　287-287　2019/10

    Publisher: (NPO)日本高血圧学会

  295. 非喫煙者における受動喫煙の有無と家庭高血圧の関連 Peer-reviewed

    平田 匠, 小暮 真奈, 成田 暁, 佐藤 倫広, 土屋 菜歩, 中村 智洋, 宇留野 晃, 小原 拓, 目時 弘仁, 中谷 直樹, 菅原 準一, 栗山 進一, 呉 繁夫, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　42回　288-288　2019/10

    Publisher: (NPO)日本高血圧学会

  296. Characterizing rare and low-frequency height-associated variants in the Japanese population. International-journal Peer-reviewed

    Akiyama M, Ishigaki K, Sakaue S, Momozawa Y, Horikoshi M, Hirata M, Matsuda K, Ikegawa S, Takahashi A, Kanai M, Suzuki S, Matsui D, Naito M, Yamaji T, Iwasaki M, Sawada N, Tanno K, Sasaki M, Hozawa A, Minegishi N, Wakai K, Tsugane S, Shimizu A, Yamamoto M, Okada Y, Murakami Y, Kubo M, Kamatani Y

    Nature communications　10　(1)　4393-4393　2019/09

    DOI： 10.1038/s41467-019-12276-5 　

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    Human height is a representative phenotype to elucidate genetic architecture. However, the majority of large studies have been performed in European population. To investigate the rare and low-frequency variants associated with height, we construct a reference panel (N = 3,541) for genotype imputation by integrating the whole-genome sequence data from 1,037 Japanese with that of the 1000 Genomes Project, and perform a genome-wide association study in 191,787 Japanese. We report 573 height-associated variants, including 22 rare and 42 low-frequency variants. These 64 variants explain 1.7% of the phenotypic variance. Furthermore, a gene-based analysis identifies two genes with multiple height-increasing rare and low-frequency nonsynonymous variants (SLC27A3 and CYP26B1; PSKAT-O < 2.5 × 10-6). Our analysis shows a general tendency of the effect sizes of rare variants towards increasing height, which is contrary to findings among Europeans, suggesting that height-associated rare variants are under different selection pressure in Japanese and European populations.

  297. Outlier detection for questionnaire data in biobanks. International-journal Peer-reviewed

    Sakurai R, Ueki M, Makino S, Hozawa A, Kuriyama S, Takai-Igarashi T, Kinoshita K, Yamamoto M, Tamiya G

    International journal of epidemiology　48　(4)　1305-1315　2019/08

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/ije/dyz012 　

    ISSN： 0300-5771

    eISSN： 1464-3685

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    <title>Abstract</title> <sec> <title>Background</title> Biobanks increasingly collect, process and store omics with more conventional epidemiologic information necessitating considerable effort in data cleaning. An efficient outlier detection method that reduces manual labour is highly desirable. </sec> <sec> <title>Method</title> We develop an unsupervised machine-learning method for outlier detection, namely kurPCA, that uses principal component analysis combined with kurtosis to ascertain the existence of outliers. In addition, we propose a novel regression adjustment approach to improve detection, namely the regression adjustment for data by systematic missing patterns (RAMP). </sec> <sec> <title>Result</title> Application to epidemiological record data in a large-scale biobank (Tohoku Medical Megabank Organization, Japan) shows that a combination of kurPCA and RAMP effectively detects known errors or inconsistent patterns. </sec> <sec> <title>Conclusions</title> We confirm through the results of the simulation and the application that our methods showed good performance. The proposed methods are useful for many practical analysis scenarios. </sec>

  298. A training and education program for genome medical research coordinators in the genome cohort study of the Tohoku Medical Megabank Organization. International-journal Peer-reviewed

    Sakurai-Yageta M, Kawame H, Kuriyama S, Hozawa A, Nakaya N, Nagami F, Minegishi N, Ogishima S, Takai-Igarashi T, Danjoh I, Obara T, Ishikuro M, Kobayashi T, Aizawa Y, Ishihara R, Yamamoto M, Suzuki Y

    BMC medical education　19　(1)　297-297　2019/08

    DOI： 10.1186/s12909-019-1725-5 　

    ISSN： 1472-6920

  299. Age-Related Trends in Home Blood Pressure, Home Pulse Rate, and Day-to-Day Blood Pressure and Pulse Rate Variability Based on Longitudinal Cohort Data: The Ohasama Study. International-journal Peer-reviewed

    Satoh M, Metoki H, Asayama K, Murakami T, Inoue R, Tsubota-Utsugi M, Matsuda A, Hirose T, Hara A, Obara T, Kikuya M, Nomura K, Hozawa A, Imai Y, Ohkubo T

    Journal of the American Heart Association　8　(15)　e012121　2019/08

    DOI： 10.1161/JAHA.119.012121 　

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    Background Home blood pressure is a more accurate prognosticator than office blood pressure and allows the observation of day-to-day blood pressure variability. Information on blood pressure change during the life course links the prediction of blood pressure elevation with age. We prospectively assessed age-related trends in home blood pressure, home pulse rate, and their day-to-day variability evaluated as a coefficient of variation. Methods and Results We examined 1665 participants (men, 36.0%; mean age, 56.2 years) from the general population of Ohasama, Japan. A repeated-measures mixed linear model was used to estimate the age-related trends. In a mean of 15.9 years, we observed 5438 points of measurements including those at baseline. The home systolic blood pressure linearly increased with age and was higher in men than in women aged <70 years. There was an inverse-U-shaped age-related trend in home diastolic blood pressure. The day-to-day home systolic blood pressure linearly increased with age in individuals aged >40 years. However, an U-shaped age-related trend in day-to-day diastolic blood pressure variability with the nadir point at 65 to 69 years of age was observed. No significant sex differences in the day-to-day blood pressure variability were observed (P≥0.22). The average and day-to-day variability of home pulse rate decreased with age but were lower and higher, respectively, in men than in women. Conclusions The current descriptive data are needed to predict future home blood pressure and pulse rate. The data also provide information on the mechanism of day-to-day blood pressure and pulse rate variability.

  300. Genome-wide association meta-analysis and Mendelian randomization analysis confirm the influence of ALDH2 on sleep durationin the Japanese population. International-journal Peer-reviewed

    Takeshi Nishiyama, Masahiro Nakatochi, Atsushi Goto, Motoki Iwasaki, Tsuyoshi Hachiya, Yoichi Sutoh, Atsushi Shimizu, Chaochen Wang, Hideo Tanaka, Miki Watanabe, Akihiro Hosono, Yuya Tamai, Tamaki Yamada, Taiki Yamaji, Norie Sawada, Kentaro Fukumoto, Kotaro Otsuka, Kozo Tanno, Hiroaki Tomita, Kaname Kojima, Masao Nagasaki, Atsushi Hozawa, Asahi Hishida, Tae Sasakabe, Yuichiro Nishida, Megumi Hara, Hidemi Ito, Isao Oze, Yohko Nakamura, Haruo Mikami, Rie Ibusuki, Toshiro Takezaki, Teruhide Koyama, Nagato Kuriyama, Kaori Endoh, Kiyonori Kuriki, Tanvir C Turin, Takashima Naoyuki, Sakurako Katsuura-Kamano, Hirokazu Uemura, Rieko Okada, Sayo Kawai, Mariko Naito, Yukihide Momozawa, Michiaki Kubo, Makoto Sasaki, Masayuki Yamamoto, Shoichiro Tsugane, Kenji Wakai, Sadao Suzuki

    Sleep　42　(6)　2019/06/11

    DOI： 10.1093/sleep/zsz046 　

    ISSN： 0161-8105

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    Usual sleep duration has substantial heritability and is associated with various physical and psychiatric conditions as well as mortality. However, for its genetic locus, only PAX8 and VRK2 have been replicated in previous genome-wide association studies (GWAS). We conducted a GWAS meta-analysis of self-reported usual sleep duration using three population-based cohorts totaling 31 230 Japanese individuals. A genome-wide significant locus was identified at 12q24 (p-value < 5.0 × 10-8). Subsequently, a functional variant in the ALDH2 locus, rs671, was replicated in an independent sample of 5140 Japanese individuals (p-value = 0.004). The association signal, however, disappeared after adjusting for alcohol consumption, indicating the possibility that the rs671 genotype modifies sleep duration via alcohol consumption. This hypothesis explained a modest genetic correlation observed between sleep duration and alcohol consumption (rG = 0.23). A Mendelian randomization analysis using rs671 and other variants as instrumental variables confirmed this by showing a causal effect of alcohol consumption, but not of coffee consumption on sleep duration. Another genome-wide significant locus was identified at 5q33 after adjusting for drinking frequency. However, this locus was not replicated, nor was the PAX8 and VRK2. Our study has confirmed that a functional ALDH2 variant, rs671, most strongly influences on usual sleep duration possibly via alcohol consumption in the Japanese population, and presumably in East Asian populations. This highlights the importance of considering the involvement of alcohol consumption in future GWAS of usual sleep duration, even in non-East Asian populations, where rs671 is monomorphic.

  301. 東日本大震災が沿岸地域の就労と精神的健康に及ぼした影響

    片柳 光昭, 富田 博秋, 瀬戸 萌, 根本 晴美, 奥山 純子, 鈴木 智美, 菅原 由美, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 小高 晃, 辻 一郎, 寳澤 篤

    精神神経学雑誌　(2019特別号)　S753-S753　2019/06

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  302. Prefabricated Temporary Housing and Eczema or Respiratory Symptoms in Schoolchildren after the Great East Japan Earthquake: The ToMMo Child Health Study. International-journal Peer-reviewed

    Kuniyoshi Y, Kikuya M, Miyashita M, Yamanaka C, Ishikuro M, Obara T, Metoki H, Nakaya N, Nagami F, Tomita H, Hozawa A, Tsuji I, Kure S, Yaegashi N, Kuriyama S

    Disaster medicine and public health preparedness　13　(5-6)　1-7　2019/06

    DOI： 10.1017/dmp.2019.8 　

    ISSN： 1935-7893

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    OBJECTIVE: We aimed to investigate the association between types of housing and allergic symptoms at 3-4 years following the Great East Japan Earthquake. METHODS: Our study was based on the ToMMo Child Health Study conducted in 2014 and 2015, a cross-sectional survey of public school children in Miyagi Prefecture, Japan. Of the 46 648 invited schoolchildren in the 2nd to 8th grades, 9884 were included. Presence of eczema, wheezing, and mental health symptoms was defined with questionnaires. To calculate odds ratios (ORs) and 95% CIs for the associations between types of housing and eczema or respiratory symptoms, we fitted generalized linear mixed models, included a random effect for municipality of residence, and adjusted for sex, school grade, survey year, and mental health symptoms. RESULTS: Prefabricated temporary housing was significantly associated with eczema symptoms (OR, 1.46; 95% CI, 1.06-2.02). Even after adjusting for the presence of mental health symptoms, our analysis produced similar results (OR, 1.42; 95% CI, 1.03-1.96). Conversely, it was not significantly associated with respiratory symptoms (OR, 0.97; 95% CI, 0.61-1.54). CONCLUSIONS: Children living in prefabricated temporary housing had a higher prevalence of eczema symptoms; however, prevalence of respiratory symptoms was not significantly higher.

  303. 一般地域住民における血清クレアチニンによる推定糸球体濾過量(eGFR)の季節差

    良知 弘務, 土屋 菜歩, 平田 匠, 中谷 直樹, 中村 智洋, 成田 暁, 小暮 真奈, 栗山 進一, 菅原 準一, 呉 繁夫, 宮崎 真理子, 寳澤 篤

    日本腎臓学会誌　61　(3)　332-332　2019/05

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  304. 東北メディカル・メガバンク計画 地域住民コホート 進捗と今後の展望

    寳澤 篤, 丹野 高三, 中谷 直樹, 平田 匠, 瀧 靖之, 栗山 進一, 菅原 準一, 坂田 清美, 辻 一郎, 呉 繁夫

    日本老年医学会雑誌　56　(Suppl.)　106-106　2019/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  305. Respiratory resistance among adults in a population-based cohort study in Northern Japan. International-journal Peer-reviewed

    Miura E, Tsuchiya N, Igarashi Y, Arakawa R, Nikkuni E, Tamai T, Tabata M, Ohkouchi S, Irokawa T, Ogawa H, Takai-Igarashi T, Suzuki Y, Kuriyama S, Tamiya G, Hozawa A, Yamamoto M, Kurosawa H

    Respiratory investigation　57　(3)　274-281　2019/05

    DOI： 10.1016/j.resinv.2018.12.008 　

    ISSN： 2212-5345

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    BACKGROUND: Forced oscillation technique (FOT) is a noninvasive method used to measure respiratory system resistance (Rrs) and reactance (Xrs) during quiet breathing, which has been extensively studied in clinical settings. The distribution of measured FOT values was previously assessed in a community-based cohort study. In this study, we aimed to confirm the distribution of measured FOT values in a different cohort in order to investigate the relationship between these values and patient clinical and biological data. METHODS: We reviewed FOT data and relevant patient clinical and biological information collected from the Community-Based Cohort Study (CommCohort Study), carried out between 2013 to 2016 as a part of the Tohoku Medical Megabank project (TMM). In total, 16,231 adults were enrolled in the study (Male/Female: 4886/11,345). RESULTS: Significant gender differences were observed in distributions of Rrs and Xrs values at 5 Hz (termed R5 and X5, respectively). R5 values in males were lower than those in females, while X5 values in males were slightly less negative. High R5 values were strongly associated with high BMI, short height, smoking status in males, high serum IgE level, and high peripheral blood eosinophil count. CONCLUSION: The present distribution values and their relation to clinical and biological data should provide useful insights for clinical settings and serve as a helpful guide in implementing FOT. Forced oscillation technique, respiratory system resistance, respiratory system reactance, gender difference, obesity.

  306. Construction of full-length Japanese reference panel of class I HLA genes with single-molecule, real-time sequencing Peer-reviewed

    Takahiro Mimori, Jun Yasuda, Yoko Kuroki, Tomoko F. Shibata, Fumiki Katsuoka, Sakae Saito, Naoki Nariai, Akira Ono, Naomi Nakai-Inagaki, Kazuharu Misawa, Keiko Tateno, Yosuke Kawai, Nobuo Fuse, Atsushi Hozawa, Shinichi Kuriyama, Junichi Sugawara, Naoko Minegishi, Kichiya Suzuki, Kengo Kinoshita, Masao Nagasaki, Masayuki Yamamoto

    The Pharmacogenomics Journal　19　(2)　136-146　2019/04/19

    Publisher: Springer Nature

    DOI： 10.1038/s41397-017-0010-4 　

    ISSN： 1470-269X

  307. 成人後の体重増加と生活習慣関連因子および生活習慣病との関連

    武部 典子, 丹野 高三, 大桃 秀樹, 佐藤 衛, 坂田 清美, 平田 匠, 寳澤 篤, 佐々木 真理, 石垣 泰

    糖尿病　62　(Suppl.1)　S-286　2019/04

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

    eISSN： 1881-588X

  308. 東北メディカル・メガバンク計画地域住民コホート調査における糖尿病研究

    平田 匠, 寳澤 篤, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 丹野 高三, 佐藤 衛, 菊谷 昌浩, 石垣 泰, 坂田 清美, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫

    糖尿病　62　(Suppl.1)　S-304　2019/04

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

    eISSN： 1881-588X

  309. Associations of Overweight, Obesity, and Underweight With High Serum Total Cholesterol Level Over 30 Years Among the Japanese Elderly: NIPPON DATA 80, 90, and 2010

    Shibata Yosuke, Ojima Toshiyuki, Nakamura Mieko, Kuwabara Kazuyo, Miyagawa Naoko, Saito Yoshino, Nakamura Yasuyuki, Kiyohara Yutaka, Nakagawa Hideaki, Fujiyoshi Akira, Kadota Aya, Ohkubo Takayoshi, Okamura Tomonori, Ueshima Hirotsugu, Okayama Akira, Miura Katsuyuki, Ueshima Hirotsugu, Miura Katsuyuki, Okayama Akira, Okamura Tomonori, Okayama Akira, Okamura Tomonori, Ueshima Hirotsugu, Okayama Akira, Okamura Tomonori, Saitoh Shigeyuki, Sakata Kiyomi, Hozawa Atsushi, Hayakawa Takehito, Nakamura Yosikazu, Nishi Nobuo, Okuda Nagako, Okamura Tomonori, Murakami Yoshitaka, Ohkubo Takayoshi, Kasagi Fumiyoshi, Izumi Toru, Matsumura Yasuhiro, Ojima Toshiyuki, Tamakoshi Koji, Nakagawa Hideaki, Kita Yoshikuni, Miura Katsuyuki, Kadota Aya, Miyamatsu Naomi, Nakamura Yasuyuki, Yoshita Katsushi, Miyamoto Yoshihiro, Kodama Kazunori, Kiyohara Yutaka

    JOURNAL OF EPIDEMIOLOGY　29　(4)　133-138　2019/04

    DOI： 10.2188/jea.JE20170229 　

    ISSN： 0917-5040

    eISSN： 1349-9092

  310. Relationship between carbohydrate and dietary fibre intake and the risk of cardiovascular disease mortality in Japanese: 24-year follow-up of NIPPON DATA80. International-journal Peer-reviewed

    Miyazawa I, Miura K, Miyagawa N, Kondo K, Kadota A, Okuda N, Fujiyoshi A, Chihara I, Nakamura Y, Hozawa A, Nakamura Y, Kita Y, Yoshita K, Okamura T, Okayama A, Ueshima H, NIPPON DATA, Research group

    European journal of clinical nutrition　74　(1)　67-76　2019/04

    DOI： 10.1038/s41430-019-0424-y 　

    ISSN： 0954-3007

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    BACKGROUND/OBJECTIVES: The association between carbohydrate intake and cardiovascular disease (CVD) risk has been investigated, but whether the quality of carbohydrate is more important than its amount is not known. We examined the associations between intake of dietary fibre (DF), carbohydrate, available carbohydrate, and starch with long-term CVD mortality in a Japanese population. SUBJECTS/METHODS: We prospectively followed 8925 participants (3916 men and 5009 women) aged 30-79 years without CVD at baseline who participated in the National Nutrition Survey in Japan. Cox proportional hazards models were used to estimate multivariable-adjusted hazard ratios (HRs) and their 95% confidence intervals (CIs) for CVD mortality by quartiles of exposure variables. RESULTS: During 24 years of follow-up, 823 CVD deaths were observed. In men, the multivariable-adjusted HR for CVD mortality was lower in the highest quartile of DF intake (HR: 0.64; 95% CI: 0.47-0.87; Ptrend = 0.007) compared with the lowest quartile. This association was not significant in women. Multivariable-adjusted HR for total stroke mortality was lower in the highest quartile of DF intake (HR: 0.61; 95% CI: 0.38-0.98; Ptrend = 0.046) compared with the lowest quartile in women. Carbohydrate, available carbohydrate, and starch intake were not associated with CVD mortality. CONCLUSIONS: Higher intake of DF was associated significantly with a lower risk of CVD mortality in men and lower risk of stroke mortality in women. Intake of carbohydrate, available carbohydrate, and starch were not associated with the risk of CVD mortality in men or women.

  311. The association of home and accurately measured office blood pressure with coronary artery calcification among general Japanese men. International-journal Peer-reviewed

    Satoh A, Arima H, Hozawa A, Ohkubo T, Hisamatsu T, Kadowaki S, Kadota A, Fujiyoshi A, Miyagawa N, Zaid M, Torii S, Okamura T, Sekikawa A, Miura K, Ueshima H, SESSA Research Group

    Journal of hypertension　37　(8)　1676-1681　2019/04

    DOI： 10.1097/HJH.0000000000002080 　

    ISSN： 0263-6352

  312. 成人における客観的睡眠効率と高血圧有病率との関連(Association of Objective Sleep Efficiency with Prevalence of Hypertension in Adults) Peer-reviewed

    平田 匠, 中村 智洋, 小暮 真奈, 成田 暁, 宮川 健, 後岡 広太郎, 土屋 菜歩, 小原 拓, 中谷 直樹, 栗山 進一, 寳澤 篤

    日本循環器学会学術集会抄録集　83回　OJ22-4　2019/03

    Publisher: (一社)日本循環器学会

  313. Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population International-journal Peer-reviewed

    Suzuki, Ken, Akiyama, Masato, Ishigaki, Kazuyoshi, Kanai, Masahiro, Hosoe, Jun, Shojima, Nobuhiro, Hozawa, Atsushi, Kadota, Aya, Kuriki, Kiyonori, Naito, Mariko, Tanno, Kozo, Ishigaki, Yasushi, Hirata, Makoto, Matsuda, Koichi, Iwata, Nakao, Ikeda, Masashi, Sawada, Norie, Yamaji, Taiki, Iwasaki, Motoki, Ikegawa, Shiro, Maeda, Shiro, Murakami, Yoshinori, Wakai, Kenji, Tsugane, Shoichiro, Sasaki, Makoto, Yamamoto, Masayuki, Okada, Yukinori, Kubo, Michiaki, Kamatani, Yoichiro, Horikoshi, Momoko, Yamauchi, Toshimasa, Kadowaki, Takashi

    NATURE GENETICS　51　(3)　379-+　2019/03

    Publisher: NATURE PUBLISHING GROUP

    DOI： 10.1038/s41588-018-0332-4 　

    ISSN： 1061-4036

    eISSN： 1546-1718

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    To understand the genetics of type 2 diabetes in people of Japanese ancestry, we conducted A meta-analysis of four genome-wide association studies (GWAS; 36,614 cases and 155,150 controls of Japanese ancestry). We identified 88 type 2 diabetes-associated loci (P &lt; 5.0 x 10(-8)) with 115 independent signals (P &lt; 5.0 x 10(-6)), of which 28 loci with 30 signals were novel. Twenty-eight missense variants were in linkage disequilibrium (r(2) &gt; 0.6) with the lead variants. Among the 28 missense variants, three previously unreported variants had distinct minor allele frequency (MAF) spectra between people of Japanese and European ancestry (MAF(JPN) &gt; 0.05 versus MAF(EUR) &lt; 0.01), including missense variants in genes related to pancreatic acinar cells (GP2) and insulin secretion (GLP1R). Transethnic comparisons of the molecular pathways identified from the GWAS results highlight both ethnically shared and heterogeneous effects of a series of pathways on type 2 diabetes (for example, monogenic diabetes and beta cells).

  314. Vegetable Protein Intake was Inversely Associated with Cardiovascular Mortality in a 15-Year Follow-Up Study of the General Japanese Population.

    Ayako Kurihara, Tomonori Okamura, Daisuke Sugiyama, Aya Higashiyama, Makoto Watanabe, Nagako Okuda, Aya Kadota, Naoko Miyagawa, Akira Fujiyoshi, Katsushi Yoshita, Takayoshi Ohkubo, Akira Okayama, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of atherosclerosis and thrombosis　26　(2)　198-206　2019/02/01

    DOI： 10.5551/jat.44172 　

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    AIM: To examine the relationship between the intake of dietary vegetable protein and CVD mortality in a 15-year follow-up study of a representative sample of the Japanese population. METHODS: A total of 7,744 participants aged 30 years or older (3,224 males and 4,520 females) who were free of CVD at baseline were included in this analysis. Vegetable protein intake (% energy) was assessed using a three-day semi-weighed dietary record at baseline. Multivariable-adjusted hazard ratios (HRs) were calculated using Cox's proportional hazards model after adjusting for confounding factors. RESULTS: The total person-years studied were 107,988 with a mean follow-up period of 13.9 years. There were 1,213 deaths during the follow-up period, among which 354 (29.2%) were due to CVD. Vegetable protein intake was associated inversely with CVD and cerebral hemorrhage mortality, with the HRs for a 1% energy increment in vegetable protein intake being 0.86 (95% CI, 0.75-0.99) and 0.58 (95% CI, 0.35-0.95), respectively. In the subgroup analysis of participants with or without hypertension, the inverse association between vegetable protein intake and CVD mortality was more evident in the nonhypertensive group, with the HRs for CVD and stroke being 0.68 (95% CI, 0.50-0.94) and 0.50 (95% CI, 0.30-0.84), respectively. CONCLUSIONS: Vegetable protein intake may prevent future CVD, particularly in nonhypertensive subjects in the Japanese population. However, further studies are necessary to examine the biological mechanisms of this effect.

  315. The Relationship of Dietary Cholesterol with Serum Low-Density Lipoprotein Cholesterol and Confounding by Reverse Causality: The INTERLIPID Study.

    Yukiko Okami, Hirotsugu Ueshima, Yasuyuki Nakamura, Nagako Okuda, Hideaki Nakagawa, Kiyomi Sakata, Shigeyuki Saitoh, Akira Okayama, Katsushi Yoshita, Sohel R Choudhury, Queenie Chan, Paul Elliott, Jeremiah Stamler, Katsuyuki Miura

    Journal of atherosclerosis and thrombosis　26　(2)　170-182　2019/02/01

    DOI： 10.5551/jat.43075 　

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    AIM: The positive relationship between dietary cholesterol and serum cholesterol has been questioned by a set of recent cohort studies. This study aimed to investigate how employment status and education years relate to the association between dietary cholesterol and serum low-density lipoprotein cholesterol (LDL-C) in a Japanese population. METHODS: A population-based, random sample, cross-sectional study (INTERLIPID) was performed. Among 1,145 Japanese individuals aged 40-59 years, 106 were excluded because of special diets, use of lipid-lowering drugs, hormone replacement, and missing data, leaving 1,039 individuals (533 men and 506 women). Dietary cholesterol was assessed from four 24-h dietary recalls, and LDL-C was measured enzymatically with an auto-analyzer. A standard questionnaire inquired about employment status and education years. RESULTS: In men, a 1 standard deviation (SD) higher dietary cholesterol was associated with 3.16 mg/dL lower serum LDL-C (P=0.009; unadjusted model). After adjustment for covariates, higher serum LDL-C was estimated per 1 SD higher intake of dietary cholesterol in nonemployed men [self-employed, homemakers, farmers, fishermen, and retired employees; β=＋9.08, 95% confidence interval (CI)=＋0.90-＋17.27] and less educated men (β=＋4.46, 95% CI=－0.97-＋9.90), whereas an inverse association was observed in employed men (β=－3.02, 95% CI=－5.49-－0.54) and more educated men (β=－3.66, 95% CI=－6.25-－1.07). CONCLUSIONS: In men who were nonemployed and less educated, a higher intake of dietary cholesterol was associated with elevated concentrations of serum LDL-C, whereas an inverse association was observed in men who were employed and more educated.

  316. Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare. International-journal Peer-reviewed

    Jun Yasuda, Kengo Kinoshita, Fumiki Katsuoka, Inaho Danjoh, Mika Sakurai-Yageta, Ikuko N Motoike, Yoko Kuroki, Sakae Saito, Kaname Kojima, Matsuyuki Shirota, Daisuke Saigusa, Akihito Otsuki, Junko Kawashima, Yumi Yamaguchi-Kabata, Shu Tadaka, Yuichi Aoki, Takahiro Mimori, Kazuki Kumada, Jin Inoue, Satoshi Makino, Miho Kuriki, Nobuo Fuse, Seizo Koshiba, Osamu Tanabe, Masao Nagasaki, Gen Tamiya, Ritsuko Shimizu, Takako Takai-Igarashi, Soichi Ogishima, Atsushi Hozawa, Shinichi Kuriyama, Junichi Sugawara, Akito Tsuboi, Hideyasu Kiyomoto, Tadashi Ishii, Hiroaki Tomita, Naoko Minegishi, Yoichi Suzuki, Kichiya Suzuki, Hiroshi Kawame, Hiroshi Tanaka, Yasuyuki Taki, Nobuo Yaegashi, Shigeo Kure, Fuji Nagami, Kenjiro Kosaki, Yoichi Sutoh, Tsuyoshi Hachiya, Atsushi Shimizu, Makoto Sasaki, Masayuki Yamamoto

    Journal of biochemistry　165　(2)　139-158　2019/02/01

    DOI： 10.1093/jb/mvy096 　

    ISSN： 0021-924X

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    Personalized healthcare (PHC) based on an individual's genetic make-up is one of the most advanced, yet feasible, forms of medical care. The Tohoku Medical Megabank (TMM) Project aims to combine population genomics, medical genetics and prospective cohort studies to develop a critical infrastructure for the establishment of PHC. To date, a TMM CommCohort (adult general population) and a TMM BirThree Cohort (birth+three-generation families) have conducted recruitments and baseline surveys. Genome analyses as part of the TMM Project will aid in the development of a high-fidelity whole-genome Japanese reference panel, in designing custom single-nucleotide polymorphism (SNP) arrays specific to Japanese, and in estimation of the biological significance of genetic variations through linked investigations of the cohorts. Whole-genome sequencing from >3,500 unrelated Japanese and establishment of a Japanese reference genome sequence from long-read data have been done. We next aim to obtain genotype data for all TMM cohort participants (>150,000) using our custom SNP arrays. These data will help identify disease-associated genomic signatures in the Japanese population, while genomic data from TMM BirThree Cohort participants will be used to improve the reference genome panel. Follow-up of the cohort participants will allow us to test the genetic markers and, consequently, contribute to the realization of PHC.

  317. Dietary inflammatory index positively associated with high-sensitivity C-reactive protein level in Japanese from NIPPON DATA2010. Peer-reviewed

    Yang Y, Hozawa A, Kogure M, Narita A, Hirata T, Nakamura T, Tsuchiya N, Nakaya N, Ninomiya T, Okuda N, Kadota A, Ohkubo T, Okamura T, Ueshima H, Okayama A, Miura K

    Journal of epidemiology　30　(2)　98-107　2019/02

    DOI： 10.2188/jea.JE20180156 　

    ISSN： 0917-5040

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    BACKGROUND: It has been reported that chronic inflammation may play an important role in the pathogenesis of several serious diseases and could be modulated by diet. Recently, the Dietary Inflammatory Index (DII®) was developed to assess the inflammatory potential of the overall diet. The DII has been reported as relevant to various diseases but has not been validated in Japanese. Thus, in the present study, we analyzed the relationship between DII scores and high-sensitivity C-reactive protein (hs-CRP) levels in a Japanese population. METHODS: Data of the National Integrated Project for Prospective Observation of Non-communicable Disease and its Trends in the Aged 2010 (NIPPON DATA2010), which contained 2,898 participants aged 20 years or older from the National Health and Nutrition Survey of Japan (NHNS2010), were analyzed. Nutrient intakes derived from 1-day semi-weighing dietary records were used to calculate DII scores. Energy was adjusted using the residual method. Levels of hs-CRP were evaluated using nephelometric immunoassay. Multiple linear regression analyses were performed. RESULTS: After adjusting for age, sex, smoking status, BMI, and physical activity, a significant association was observed between DII scores and log(CRP+1) (standard regression coefficient = 0.05, P < 0.01). Although it was not statistically significant, the positive association was consistently observed in almost all age-sex subgroups and the non-smoker subgroup. CONCLUSIONS: The current study confirmed that DII score was positively associated with hs-CRP in Japanese.

  318. Having few remaining teeth is associated with a low nutrient intake and low serum albumin levels in middle-aged and older Japanese individuals: findings from the NIPPON DATA2010. International-journal Peer-reviewed

    Mieko Nakamura, Toshiyuki Ojima, Tomomi Nagahata, Imako Kondo, Toshiharu Ninomiya, Katsushi Yoshita, Yusuke Arai, Takayoshi Ohkubo, Keiko Murakami, Nobuo Nishi, Yoshitaka Murakami, Naoyuki Takashima, Nagako Okuda, Aya Kadota, Naoko Miyagawa, Keiko Kondo, Tomonori Okamura, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura

    Environmental health and preventive medicine　24　(1)　1-1　2019/01/05

    DOI： 10.1186/s12199-018-0752-x 　

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    BACKGROUND: Oral health is thought to be associated with diet quality, and socioeconomic status (SES) affects both oral health and diet. The aim of this study was to investigate the association between the number of teeth and dietary intake as well as nutritional biomarker, considering the subjects' SES. METHODS: We conducted a cross-sectional analysis of data from 2049 individuals aged ≥ 50 years from the National Integrated Project for Prospective Observation of Non-communicable Disease and its Trends in the Aged 2010. The number of remaining teeth was categorized into age-specific quartiles (Q1 to Q4). We assessed the adjusted means and 95% confidence intervals for dietary variables by the number of teeth using analysis of covariance. Stratified analyses by SES were also conducted. RESULTS: The intake of grain products was 31 g higher, and those of vegetables and meat were 30 g and 8 g lower, respectively, in Q1 (fewer teeth) than in Q4 (more teeth). Carbohydrate intake was higher whereas protein, minerals (potassium, magnesium, and zinc), vitamins (vitamins A, E, B1, B6, β-carotene, and folic acid), and dietary fiber intakes were lower among individuals with fewer teeth. Adjusted mean serum albumin levels were low in Q1. The associations between the number of teeth and dietary intake were more evident in individuals with a low SES. CONCLUSIONS: Having few remaining teeth was associated with a low nutrient intake and low serum albumin levels in middle-aged and older Japanese adults, and these associations were more evident in individuals with low SES.

  319. Cardiovascular risk assessment chart by dietary factors in Japan: NIPPON DATA80

    Keiko Kondo, Katsuyuki Miura, Sachiko Tanaka-Mizuno, Aya Kadota, Hisatomi Arima, Nagako Okuda, Akira Fujiyoshi, Naoko Miyagawa, Katsushi Yoshita, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima, NIPPON DATA80 Research Group

    Circulation Journal　83　(6)　1254-1260　2019

    Publisher: Japanese Circulation Society

    DOI： 10.1253/circj.CJ-18-1002 　

    ISSN： 1347-4820 1346-9843

  320. Management of family relationship information for a three-generation cohort study

    Shimokawa K, Ishikuro M, Obara T, Metoki H, Mizuno S, Nagaie S, Nagai M, Yamanaka C, Matsubara H, Kato M, Sato Y, Ogishima S, Takai-Igarashi T, Kikuya M, Hozawa A, Nagami F, Kuriyama S, Kinoshita K, Yamamoto M, Tanaka H

    bioRxiv　2019/01

  321. Association of alcohol consumption with fat deposition in a community-based sample of Japanese men: The Shiga epidemiological study of subclinical atherosclerosis (SESSA) Peer-reviewed

    Sumi M, Hisamatsu T, Fujiyoshi A, Kadota A, Miyagawa N, Kondo K, Kadowaki S, Suzuki S, Torii S, Zaid M, Sato A, Arima H, Terada T, Miura K, Ueshima H, Horie M, Nakano Y, Yamamoto T, Hayashi H, Ogawa E, Maegawa H, Miyazawa I, Murata K, Mitsunami K, Nozaki K, Tooyama I, Shiino A, Tsuru T, Ogita H, Shimizu A, Miyamatsu N, Kita T, Kimura T, Nishio Y, Nakamura Y, Okamura T, Sekikawa A, Barinas-Mitchell E.J, Edmundowicz D, Ohkubo T, Hozawa A, Miyagi S, Murakami Y, Okuda N, Kita Y, Higashiyama A, Nagasawa S, Azuma K, Yanagita M, Abbott R.D, Ohno S, Takashima N, Kadowaki T, Saito Y, Ito T, Satoh A, Yamazoe M

    Journal of Epidemiology　29　(6)　205-212　2019

    DOI： 10.2188/jea.JE20170191 　

  322. Time-Related Changes in Relationships Between the Keys Score, Dietary Lipids, and Serum Total Cholesterol in Japan - NIPPON DATA80/90/2010-

    Okami Yukiko, Ueshima Hirotsugu, Nakamura Yasuyuki, Kondo Keiko, Kadota Aya, Okuda Nagako, Okamura Tomonori, Miura Katsuyuki, Fujiyoshi Akira, Hozawa Atsushi, Kadota Aya, Kasagi Fumiyoshi, Nakagawa Hideaki, Toyoshima Hideaki, Yanagawa Hiroshi, Yoshita Katsushi, Kodama Kazunori, Ueda Kazuo, Sakata Kiyomi, Tamakoshi Koji, Okuda Nagako, Miyamatsu Naomi, Nishi Nobuo, Saitoh Shigeyuki, Tokudome Shinkan, Okubo Takayoshi, Hayakawa Takehito, Izumi Toru, Ojima Toshiyuki, Matsumura Yasuhiro, Miyamoto Yoshihiro, Kita Yoshikuni, Murakami Yoshitaka, Nakamura Yoshikazu, Kiyohara Yutaka

    CIRCULATION JOURNAL　83　(1)　147-+　2019/01

    DOI： 10.1253/circj.CJ-18-0628 　

    ISSN： 1346-9843

    eISSN： 1347-4820

  323. Susceptibility Loci for Tanning Ability in the Japanese Population Identified by a Genome-Wide Association Study from the Tohoku Medical Megabank Project Cohort Study. International-journal Peer-reviewed

    Shido K, Kojima K, Yamasaki K, Hozawa A, Tamiya G, Ogishima S, Minegishi N, Kawai Y, Tanno K, Suzuki Y, Nagasaki M, Aiba S

    The Journal of investigative dermatology　139　(7)　1605-1608.e13　2019/01

    DOI： 10.1016/j.jid.2019.01.015 　

    ISSN： 0022-202X

    eISSN： 1523-1747

  324. Significant Association of House Collapse With High Urine Na/K Ratios Among 24,580 Coastal Residents Who Survived the Great East Japan Earthquake Peer-reviewed

    Takahiro Mikami, Kozo Tanno, Ryohei Sasaki, Nobuyuki Takanashi, Yuka Kotozaki, Atsushi Hozawa, Mana Kogure, Shinichi Kuriyama, Ichiro Tsuji, Mamoru Sato, Jiro Hitomi, Kiyomi Sakata, Makoto Sasaki

    CIRCULATION　139　2019

    DOI： 10.1161/circ.139.suppl_1.P086 　

    ISSN： 0009-7322

    eISSN： 1524-4539

  325. 3.5KJPNv2: an allele frequency panel of 3552 Japanese individuals including the X chromosome. International-journal Peer-reviewed

    Tadaka S, Katsuoka F, Ueki M, Kojima K, Makino S, Saito S, Otsuki A, Gocho C, Sakurai-Yageta M, Danjoh I, Motoike IN, Yamaguchi-Kabata Y, Shirota M, Koshiba S, Nagasaki M, Minegishi N, Hozawa A, Kuriyama S, Shimizu A, Yasuda J, Fuse N, Tohoku Medical Megabank Project, Study Group, Tamiya G, Yamamoto M, Kinoshita K

    Human genome variation　6　(1)　28-28　2019

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41439-019-0059-5 　

    eISSN： 2054-345X

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    The first step towards realizing personalized healthcare is to catalog the genetic variations in a population. Since the dissemination of individual-level genomic information is strictly controlled, it will be useful to construct population-level allele frequency panels with easy-to-use interfaces. In the Tohoku Medical Megabank Project, we sequenced nearly 4000 individuals from a Japanese population and constructed an allele frequency panel of 3552 individuals after removing related samples. The panel is called the 3.5KJPNv2. It was constructed by using a standard pipeline including the 1KGP and gnomAD algorithms to reduce technical biases and to allow comparisons to other populations. Our database is the first large-scale panel providing the frequencies of variants present on the X chromosome and on the mitochondria in the Japanese population. All the data are available on our original database at https://jmorp.megabank.tohoku.ac.jp.

  326. Interethnic analyses of blood pressure loci in populations of East Asian and European descent. International-journal Peer-reviewed

    Takeuchi F, Akiyama M, Matoba N, Katsuya T, Nakatochi M, Tabara Y, Narita A, Saw WY, Moon S, Spracklen CN, Chai JF, Kim YJ, Zhang L, Wang C, Li H, Li H, Wu JY, Dorajoo R, Nierenberg JL, Wang YX, He J, Bennett DA, Takahashi A, Momozawa Y, Hirata M, Matsuda K, Rakugi H, Nakashima E, Isono M, Shirota M, Hozawa A, Ichihara S, Matsubara T, Yamamoto K, Kohara K, Igase M, Han S, Gordon-Larsen P, Huang W, Lee NR, Adair LS, Hwang MY, Lee J, Chee ML, Sabanayagam C, Zhao W, Liu J, Reilly DF, Sun L, Huo S, Edwards TL, Long J, Chang LC, Chen CH, Yuan JM, Koh WP, Friedlander Y, Kelly TN, Bin Wei W, Xu L, Cai H, Xiang YB, Lin K, Clarke R, Walters RG, Millwood IY, Li L, Chambers JC, Kooner JS, Elliott P, van der Harst P, International, Genomics of, Blood Pressure, iGEN-BP) Consortium, Chen Z, Sasaki M, Shu XO, Jonas JB, He J, Heng CK, Chen YT, Zheng W, Lin X, Teo YY, Tai ES, Cheng CY, Wong TY, Sim X, Mohlke KL, Yamamoto M, Kim BJ, Miki T, Nabika T, Yokota M, Kamatani Y, Kubo M, Kato N

    Nature communications　9　(1)　5052-5052　2018/11

    DOI： 10.1038/s41467-018-07345-0 　

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    Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.

  327. Strategic Methods for Recruiting Grandparents: The Tohoku Medical Megabank Birth and Three-Generation Cohort Study. Peer-reviewed

    Mami Ishikuro, Taku Obara, Tamae Osanai, Chizuru Yamanaka, Yuki Sato, Satoshi Mizuno, Masako Miyashita, Masahiro Kikuya, Kasumi Sakurai, Atsushi Hozawa, Hiroaki Tomita, Yasuyuki Taki, Fuji Nagami, Hirohito Metoki, Shinichi Kuriyama

    The Tohoku journal of experimental medicine　246　(2)　97-105　2018/10

    DOI： 10.1620/tjem.246.97 　

    ISSN： 0040-8727

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    Involvement of family members, especially grandparents, in genome epidemiological research is important to investigate both genetic and environmental factors of common diseases. The aim of the present study was to establish strategies to obtain enough number of family recruitment, especially focusing on grandparents, for the Tohoku Medical Megabank Birth and Three-Generation Cohort Study. Our main strategies are summarized below. 1) We standardized informed consent process with reference materials to help people understand the consent form, 2) we created an invitation letter to contact family members, and 3) we recruited family members in several settings. To obtain informed consent, we were careful of explaining clearly the complex reasons as well as drawing people's attention. By the end of March 2017, the number of invitation letters distributed to family members through the pregnant women was 23,806, including 18,702 grandparents. Among the grandparents who received invitation letters, 2,935 (15.7%) responded to us. Furthermore, some grandparents were asked to provide informed consent with other family members by staff at maternal clinics or Community Support Centers, and others directly booked Community Support Centers without responding to the invitation letter. Grandparents joined the study anytime during mother's maternal check-ups or delivery. Overall, 8,054 grandparents participated in our birth cohort study. The setting in which most grandparents were recruited was our own facilities. Importantly, both paternal and maternal grandparents more frequently participated in the study if the father also participated. In conclusion, we are able to recruit not only pregnant women but also fathers and grandparents.

  328. Severity of eczema and mental health problems in Japanese schoolchildren: The ToMMo Child Health Study. International-journal Peer-reviewed

    Yasutaka Kuniyoshi, Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, Taku Obara, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Atsushi Hozawa, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama

    Allergology international : official journal of the Japanese Society of Allergology　67　(4)　481-486　2018/10

    DOI： 10.1016/j.alit.2018.02.009 　

    ISSN： 1323-8930

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    BACKGROUND: The association between eczema and mental health problems in schoolchildren has been underexplored. We aimed to investigate this association with the validated questionnaires. METHODS: Of 46,648 invited children, we analyzed 9954 (21.3%) in the 2nd to the 8th grades from the ToMMo Child Health Study conducted in 2014 and 2015, a cross-sectional survey in Miyagi Prefecture, Japan. We defined eczema status as "normal," "mild/moderate," or "severe," based on the presence of persistent flexural eczema and sleep disturbance, according to the International Study of Asthma and Allergies in Childhood (ISAAC) Eczema Symptom Questionnaire. Clinical ranges of Strengths and Difficulties Questionnaire (SDQ) total difficulties scores and four SDQ subcategories of emotional symptoms, conduct problems, hyperactivity/inattention, and peer problems were defined as scores ≥16, ≥5, ≥5, ≥7, and ≥5, respectively. RESULTS: The mean SDQ total difficulties score significantly increased as eczema status worsened (all P ≤ 0.004 for trend). The OR of scores in the clinical range for SDQ total difficulties were 1.51 (95% CI, 1.31-1.74) for mild/moderate eczema and 2.63 (95% CI, 1.91-3.63) for severe eczema (P < 0.001 for trend), adjusted for sex, school grade, current wheeze, and disaster-related factors, using normal eczema as a reference. The association between severity of eczema and four SDQ subcategories showed a similar trend (all P ≤ 0.017 for trend). CONCLUSIONS: We found a significant association between severity of eczema and mental health problems. The presence of eczema was associated with four SDQ subcategories.

  329. Associations of High-Density Lipoprotein Particle and High-Density Lipoprotein Cholesterol With Alcohol Intake, Smoking, and Body Mass Index - The INTERLIPID Study.

    Maryam Zaid, Katsuyuki Miura, Akira Okayama, Hideaki Nakagawa, Kiyomi Sakata, Shigeyuki Saitoh, Nagako Okuda, Katsushi Yoshita, Sohel R Choudhury, Beatriz Rodriguez, Kamal Masaki, Bradley Willcox, Naoko Miyagawa, Tomonori Okamura, Queenie Chan, Paul Elliott, Jeremiah Stamler, Hirotsugu Ueshima

    Circulation journal : official journal of the Japanese Circulation Society　82　(10)　2557-2565　2018/09/25

    DOI： 10.1253/circj.CJ-18-0341 　

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    BACKGROUND: Recently, high-density lipoprotein particles (HDL-P) have been found to be more strongly inversely associated with coronary artery disease (CAD) risk than their counterpart, HDL cholesterol (HDL-C). Given that lifestyle is among the first targets in CAD prevention, we compared the associations of HDL-P and HDL-C with selected lifestyle factors. Methods and Results: We examined 789 Japanese participants of the INTERLIPID Study: men (n=386) and women (n=403) aged 40-59 years in 1996-1998. Participants treated for dyslipidemias were excluded. Lifestyle factors included alcohol intake, smoking amount, and body mass index (BMI). Multivariable linear regression was used for cross-sectional analyses of these factors with HDL-P, HDL-C, HDL-P size subclasses (small, medium and large) and mean HDL-P size. In men, higher alcohol intake was associated with higher HDL-P and higher HDL-C. The associations of alcohol, however, were strongest with HDL-P. A higher smoking amount tended to be associated with lower HDL-P and HDL-C. In contrast, BMI was not associated with HDL-P, but was strongly inversely associated with HDL-C. While alcohol intake favored larger mean HDL-P size, smoking and BMI favored a lipid profile with smaller HDL-P subclasses and overall smaller mean HDL-P size. Similar, but generally weaker results were observed in women. CONCLUSIONS: Although both HDL-P and HDL-C are parameters of HDL, they have different associations with alcohol, smoking and BMI.

  330. Genome-wide analysis of polymorphism × sodium interaction effect on blood pressure identifies a novel 3'-BCL11B gene desert locus. International-journal Peer-reviewed

    Hachiya T, Narita A, Ohmomo H, Sutoh Y, Komaki S, Tanno K, Satoh M, Sakata K, Hitomi J, Nakamura M, Ogasawara K, Yamamoto M, Sasaki M, Hozawa A, Shimizu A

    Scientific reports　8　(1)　14162-14162　2018/09

    DOI： 10.1038/s41598-018-32074-1 　

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    Excessive sodium intake is a global risk factor for hypertension. Sodium effects on blood pressure vary from person to person; hence, high-risk group targeting based on personal genetic information can play a complementary role to ongoing population preventive approaches to reduce sodium consumption. To identify genetic factors that modulate sodium effects on blood pressure, we conducted a population-based genome-wide interaction analysis in 8,768 Japanese subjects, which was >3 times larger than a similar previous study. We tested 7,135,436 polymorphisms in the discovery cohort, and loci that met suggestive significance were further examined in an independent replication cohort. We found that an interaction between a novel 3'-BCL11B gene desert locus and daily sodium consumption was significantly associated with systolic blood pressure in both discovery and replication cohorts under the recessive model. Further statistical analysis of rs8022678, the sentinel variant of the 3'-BCL11B gene desert locus, showed that differences in mean systolic blood pressure between high and low sodium consumption subgroups were 5.9 mm Hg (P = 8.8 × 10-12) in rs8022678 A carriers and -0.3 mm Hg (P = 0.27) in rs8022678 A non-carriers, suggesting that the rs8022678 genotype can classify persons into sodium-sensitive (A carriers) and sodium-insensitive (A non-carriers) subgroups. Our results implied that rs8022678 A carriers may receive a greater benefit from sodium-lowering interventions than non-carriers.

  331. Associations between Socioeconomic Status and the Prevalence and Treatment of Hypercholesterolemia in a General Japanese Population: NIPPON DATA2010. Peer-reviewed

    Fujiyoshi N, Arima H, Satoh A, Ojima T, Nishi N, Okuda N, Kadota A, Ohkubo T, Hozawa A, Nakaya N, Fujiyoshi A, Okamura T, Ueshima H, Okayama A, Miura K, NIPPON DATA, Research Group

    Journal of atherosclerosis and thrombosis　25　(7)　606-620　2018/07

    DOI： 10.5551/jat.42531 　

    ISSN： 1340-3478

  332. Development of a Highly Sensitive Device for Counting the Number of Disease-Specific Exosomes in Human Sera. Peer-reviewed

    Kabe Y, Suematsu M, Sakamoto S, Hirai M, Koike I, Hishiki T, Matsuda A, Hasegawa Y, Tsujita K, Ono M, Minegishi N, Hozawa A, Murakami Y, Kubo M, Itonaga M, Handa H

    Clinical chemistry　64　(10)　1463-1473　2018/07

    DOI： 10.1373/clinchem.2018.291963 　

    ISSN： 0009-9147

    eISSN： 1530-8561

  333. Effect of tsunami drill experience on evacuation behavior after the onset of the Great East Japan Earthquake Peer-reviewed

    Naoki Nakaya, Harumi Nemoto, Carine Yi, Ayako Sato, Kotomi Shingu, Tomoka Shoji, Shosuke Sato, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Yumi Sugawara, Zhiqian Yu, Nicole Gunawansa, Shinichi Kuriyama, Osamu Murao, Takeshi Sato, Fumihiko Imamura, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

    International Journal of Disaster Risk Reduction　28　206-213　2018/06/01

    DOI： 10.1016/j.ijdrr.2018.02.037 　

    ISSN： 2212-4209

  334. Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project. International-journal Peer-reviewed

    Seizo Koshiba, Ikuko Motoike, Daisuke Saigusa, Jin Inoue, Matsuyuki Shirota, Yasutake Katoh, Fumiki Katsuoka, Inaho Danjoh, Atsushi Hozawa, Shinichi Kuriyama, Naoko Minegishi, Masao Nagasaki, Takako Takai-Igarashi, Soichi Ogishima, Nobuo Fuse, Shigeo Kure, Gen Tamiya, Osamu Tanabe, Jun Yasuda, Kengo Kinoshita, Masayuki Yamamoto

    Genes to cells : devoted to molecular & cellular mechanisms　23　(6)　406-417　2018/06

    DOI： 10.1111/gtc.12588 　

    ISSN： 1356-9597

  335. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes Peer-reviewed

    Rainer Malik, Ganesh Chauhan, Matthew Traylor, Muralidharan Sargurupremraj, Yukinori Okada, Aniket Mishra, Loes Rutten-Jacobs, Anne-Katrin Giese, Sander W. Van Der Laan, Solveig Gretarsdottir, Christopher D. Anderson, Michael Chong, Hieab H. H. Adams, Tetsuro Ago, Peter Almgren, Philippe Amouyel, Hakan Ay, Traci M. Bartz, Oscar R. Benavente, Steve Bevan, Giorgio B. Boncoraglio, Robert D. Brown, Adam S. Butterworth, Caty Carrera, Cara L. Carty, Daniel I. Chasman, Wei-Min Chen, John W. Cole, Adolfo Correa, Ioana Cotlarciuc, Carlos Cruchaga, John Danesh, Paul I. W. De Bakker, Anita L. Destefano, Marcel Den Hoed, Qing Duan, Stefan T. Engelter, Guido J. Falcone, Rebecca F. Gottesman, Raji P. Grewal, Vilmundur Gudnason, Stefan Gustafsson, Jeffrey Haessler, Tamara B. Harris, Ahamad Hassan, Aki S. Havulinna, Susan R. Heckbert, Elizabeth G. Holliday, George Howard, Fang-Chi Hsu, Hyacinth I. Hyacinth, M. Arfan Ikram, Erik Ingelsson, Marguerite R. Irvin, Xueqiu Jian, Jordi Jiménez-Conde, Julie A. Johnson, J. Wouter Jukema, Masahiro Kanai, Keith L. Keene, Brett M. Kissela, Dawn O. Kleindorfer, Charles Kooperberg, Michiaki Kubo, Leslie A. Lange, Carl D. Langefeld, Claudia Langenberg, Lenore J. Launer, Jin-Moo Lee, Robin Lemmens, Didier Leys, Cathryn M. Lewis, Wei-Yu Lin, Arne G. Lindgren, Erik Lorentzen, Patrik K. Magnusson, Jane Maguire, Ani Manichaikul, Patrick F. McArdle, James F. Meschia, Braxton D. Mitchell, Thomas H. Mosley, Michael A. Nalls, Toshiharu Ninomiya, Martin J. O'Donnell, Bruce M. Psaty, Sara L. Pulit, Kristiina Rannikmäe, Alexander P. Reiner, Kathryn M. Rexrode, Kenneth Rice, Stephen S. Rich, Paul M. Ridker, Natalia S. Rost, Peter M. Rothwell, Jerome I. Rotter, Tatjana Rundek, Ralph L. Sacco, Saori Sakaue, Michele M. Sale, Veikko Salomaa, Bishwa R. Sapkota, Reinhold Schmidt, Carsten O. Schmidt, Ulf Schminke, Pankaj Sharma, Agnieszka Slowik, Cathie L. M. Sudlow, Christian Tanislav, Turgut Tatlisumak, Kent D. Taylor, Vincent N. S. Thijs, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Steffen Tiedt, Stella Trompet, Christophe Tzourio, Cornelia M. Van Duijn, Matthew Walters, Nicholas J. Wareham, Sylvia Wassertheil-Smoller, James G. Wilson, Kerri L. Wiggins, Qiong Yang, Salim Yusuf, Joshua C. Bis, Tomi Pastinen, Arno Ruusalepp, Eric E. Schadt, Simon Koplev, Johan L. M. Björkegren, Veronica Codoni, Mete Civelek, Nicholas L. Smith, David A. Trégouët, Ingrid E. Christophersen, Carolina Roselli, Steven A. Lubitz, Patrick T. Ellinor, E. Shyong Tai, Jaspal S. Kooner, Norihiro Kato, Jiang He, Pim Van Der Harst, Paul Elliott, John C. Chambers, Fumihiko Takeuchi, Andrew D. Johnson, Dharambir K. Sanghera, Olle Melander, Christina Jern, Daniel Strbian, Israel Fernandez-Cadenas, W. T. Longstreth, Arndt Rolfs, Jun Hata, Daniel Woo, Jonathan Rosand, Guillaume Pare, Jemma C. Hopewell, Danish Saleheen, Kari Stefansson, Bradford B. Worrall, Steven J. Kittner, Sudha Seshadri, Myriam Fornage, Hugh S. Markus, Joanna M. M. Howson, Yoichiro Kamatani, Stephanie Debette, Martin Dichgans, Najaf Amin, Hugo S. Aparicio, Donna K. Arnett, John Attia, Alexa S. Beiser, Claudine Berr, Julie E. Buring, Mariana Bustamante, Valeria Caso, Yu-Ching Cheng, Seung Hoan Choi, Ayesha Chowhan, Natalia Cullell, Jean-François Dartigues, Hossein Delavaran, Pilar Delgado, Marcus Dörr, Gunnar Engström, Ian Ford, Wander S. Gurpreet, Anders Hamsten, Laura Heitsch, Atsushi Hozawa, Laura Ibanez, Andreea Ilinca, Martin Ingelsson, Motoki Iwasaki, Rebecca D. Jackson, Katarina Jood, Pekka Jousilahti, Sara Kaffashian, Lalit Kalra, Masahiro Kamouchi, Takanari Kitazono, Olafur Kjartansson, Manja Kloss, Peter J. Koudstaal, Jerzy Krupinski, Daniel L. Labovitz, Cathy C. Laurie, Christopher R. Levi, Linxin Li, Lars Lind, Cecilia M. Lindgren, Vasileios Lioutas, Yong Mei Liu, Oscar L. Lopez, Hirata Makoto, Nicolas Martinez-Majander, Koichi Matsuda, Naoko Minegishi, Joan Montaner, Andrew P. Morris, Elena Muiño, Martina Müller-Nurasyid, Bo Norrving, Soichi Ogishima, Eugenio A. Parati, Leema Reddy Peddareddygari, Nancy L. Pedersen, Joanna Pera, Markus Perola, Alessandro Pezzini, Silvana Pileggi, Raquel Rabionet, Iolanda Riba-Llena, Marta Ribasés, Jose R. Romero, Jaume Roquer, Anthony G. Rudd, Antti-Pekka Sarin, Ralhan Sarju, Chloe Sarnowski, Makoto Sasaki, Claudia L. Satizabal, Mamoru Satoh, Naveed Sattar, Norie Sawada, Gerli Sibolt, Ásgeir Sigurdsson, Albert Smith, Kenji Sobue, Carolina Soriano-Tárraga, Tara Stanne, O. Colin Stine, David J. Stott, Konstantin Strauch, Takako Takai, Hideo Tanaka, Kozo Tanno, Alexander Teumer, Liisa Tomppo, Nuria P. Torres-Aguila, Emmanuel Touze, Shoichiro Tsugane, Andre G. Uitterlinden, Einar M. Valdimarsson, Sven J. Van Der Lee, Henry Völzke, Kenji Wakai, David Weir, Stephen R. Williams, Charles D. A. Wolfe, Quenna Wong, Huichun Xu, Taiki Yamaji, AFGen Consortium

    Nature Genetics　50　(4)　524-537　2018/04/01

    Publisher: Nature Publishing Group

    DOI： 10.1038/s41588-018-0058-3 　

    ISSN： 1546-1718 1061-4036

    eISSN： 1546-1718

  336. Estimating frequency of pathogenic variants in a Japanese population by using the whole-genome reference panel of ToMMo Peer-reviewed

    Yumi Yamaguchi-Kabata, Jun Yasuda, Osamu Tanabe, Yoichi Suzuki, Hiroshi Kawame, Nobuo Fuse, Masao Nagasaki, Yosuke Kawai, Kaname Kojima, Fumiki Katsuoka, Sakae Saito, Inaho Danjoh, Ikuko N. Motoike, Riu Yamashita, Seizo Koshiba, Daisuke Saigusa, Gen Tamiya, Shigeo Kure, Nobuo Yaegashi, Yoshio Kawaguchi, Fuji Nagami, Shinichi Kuriyama, Junichi Sugawara, Naoko Minegishi, Atsushi Hozawa, Soichi Ogishima, Hideyasu Kiyomoto, Takako Takai-Igarashi, Kengo Kinoshita, Masayuki Yamamoto

    HUMAN GENOMICS　12　2018/03/09

    ISSN： 1473-9542

    eISSN： 1479-7364

  337. Social Inequalities in Secondhand Smoke Among Japanese Non-smokers: A Cross-Sectional Study. Peer-reviewed

    Yusuke Matsuyama, Jun Aida, Toru Tsuboya, Shihoko Koyama, Yukihiro Sato, Atsushi Hozawa, Ken Osaka

    Journal of epidemiology　28　(3)　133-139　2018/03/05

    DOI： 10.2188/jea.JE20160184 　

    ISSN： 0917-5040

  338. 東北メディカル・メガバンク地域住民コホート調査に基づく、日本人呼気一酸化窒素濃度の分布と影響因子の解析(中間報告) Peer-reviewed

    山田 充啓, 杉浦 久敏, 布施 昇男, 寳澤 篤, 高井 貴子, 土屋 奈歩, 光根 歩, 栗山 進一, 山本 雅之, 一ノ瀬 正和

    日本呼吸器学会誌　7　(増刊)　213-213　2018/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

    eISSN： 2186-5884

  339. The Association between Woman's Own Birth Weight and Her Subsequent Risk for Hypertensive Disorders of Pregnancy. Peer-reviewed

    Wagata Maiko, Tsuchiya Naho, Nakaya Naoki, Ishikuro Mami, Metoki Hirohito, Hozawa Atsushi, Kuriyama Shinichi, Yaegashi Nobuo, Sugawara Junichi

    REPRODUCTIVE SCIENCES　25　240A　2018/03

    ISSN： 1933-7191

  340. Dietary tofu intake and long-term risk of death from stroke in a general population Peer-reviewed

    Ho N. Nguyen, Naoko Miyagawa, Katsuyuki Miura, Nagako Okuda, Katsushi Yoshita, Yusuke Arai, Hideaki Nakagawa, Kiyomi Sakata, Toshiyuki Ojima, Aya Kadota, Naoyuki Takashima, Akira Fujiyoshi, Takayoshi Ohkubo, Robert D. Abbott, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima, NIPPON DATA80 Research Group

    Clinical Nutrition　37　(1)　182-188　2018/02/01

    Publisher: Churchill Livingstone

    DOI： 10.1016/j.clnu.2016.11.021 　

    ISSN： 1532-1983 0261-5614

  341. Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2049 individuals. International-journal Peer-reviewed

    Yumi Yamaguchi-Kabata, Jun Yasuda, Osamu Tanabe, Yoichi Suzuki, Hiroshi Kawame, Nobuo Fuse, Masao Nagasaki, Yosuke Kawai, Kaname Kojima, Fumiki Katsuoka, Sakae Saito, Inaho Danjoh, Ikuko N Motoike, Riu Yamashita, Seizo Koshiba, Daisuke Saigusa, Gen Tamiya, Shigeo Kure, Nobuo Yaegashi, Yoshio Kawaguchi, Fuji Nagami, Shinichi Kuriyama, Junichi Sugawara, Naoko Minegishi, Atsushi Hozawa, Soichi Ogishima, Hideyasu Kiyomoto, Takako Takai-Igarashi, Kengo Kinoshita, Masayuki Yamamoto

    Journal of human genetics　63　(2)　213-230　2018/02

    DOI： 10.1038/s10038-017-0347-1 　

    ISSN： 1434-5161

  342. The Influence of the Japanese Nationwide Cardiovascular Prevention System Health Guidance on Smoking Cessation Among Smokers: A Propensity Score Matching Analysis

    Koshi Nakamura, Makoto Watanabe, Nagako Okuda, Katsushi Yoshita, Mai Kabayama, Sayuki Torii, Toru Kuribayashi, Kazuyoshi Itai, Kei Kamide, Katsuyuki Miura, Akira Okayama

    Journal of Atherosclerosis and Thrombosis　25　(4)　323-334　2018

    Publisher: Japan Atherosclerosis Society

    DOI： 10.5551/jat.42051 　

    ISSN： 1340-3478

    eISSN： 1880-3873

  343. Effectiveness of a Self-monitoring Device for Urinary Sodium-to-Potassium Ratio on Dietary Improvement in Free-Living Adults: a Randomized Controlled Trial

    Toshiyuki Iwahori, Hirotsugu Ueshima, Naoto Ohgami, Hideyuki Yamashita, Naoko Miyagawa, Keiko Kondo, Sayuki Torii, Katsushi Yoshita, Toshikazu Shiga, Takayoshi Ohkubo, Hisatomi Arima, Katsuyuki Miura

    Journal of Epidemiology　28　(1)　41-47　2018

    Publisher: Japan Epidemiological Association

    DOI： 10.2188/jea.je20160144 　

    ISSN： 0917-5040

    eISSN： 1349-9092

  344. Relationship Between Socioeconomic Status and the Prevalence of Underweight, Overweight or Obesity in a General Japanese Population: NIPPON DATA2010.

    Tomiyo Nakamura, Yasuyuki Nakamura, Shigeyuki Saitoh, Tomonori Okamura, Masahiko Yanagita, Katsushi Yoshita, Yoshikuni Kita, Yoshitaka Murakami, Hiroshi Yokomichi, Nobuo Nishi, Nagako Okuda, Aya Kadota, Takayoshi Ohkubo, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura

    Journal of epidemiology　28 Suppl 3　S10-S16　2018

    DOI： 10.2188/jea.JE20170249 　

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    BACKGROUND: Socioeconomic status (SES) imbalances in developed and developing countries may result in individuals being overweight and obese. However, few studies have investigated this issue in Japan. We herein examined the relationship between SES and being underweight, overweight or obese according to sex and age groups (20-64 or ≥65 years) in Japan. METHODS: In 2010, we established a cohort of participants in the National Health and Nutrition Survey of Japan. We divided 2,491 participants (1,081 men and 1,410 women) according to the WHO definitions of underweight, overweight or obesity and performed multinomial logistic analyses using BMI <18.5 kg/m2 (underweight), BMI 25.0-29.9 kg/m2 (overweight), and BMI ≥30.0 kg/m2 (obese) versus BMI 18.5-24.9 kg/m2 (normal) as the outcome, with SES groups as the main explanatory variables. RESULTS: In adult men, a lower education level relative to a higher education level was inversely associated with obesity after adjustments for other SESs (odds ratio [OR] 0.41; 95% confidence interval [CI], 0.18-0.96). However, in adult women, lower education level was positively associated with being overweight and obese (OR 1.67; 95% CI, 1.07-2.49 for overweight and OR 2.66; 95% CI, 1.01-7.01 for obese). In adult women, a lower household income was positively associated with being overweight and obese (obese: OR 4.84; 95% CI, 1.36-17.18 for those with a household income <2 million JPY relative to those with ≥6 million JPY). CONCLUSIONS: In adult women, a lower education level and lower household income were positively associated with being overweight or obese. In contrast, in adult men, a lower education level was inversely associated with obesity. Gender and age differences in SESs affect the prevalence of being overweight or obese.

  345. Macronutrient Intake and Socioeconomic Status: NIPPON DATA2010.

    Masaru Sakurai, Hideaki Nakagawa, Aya Kadota, Katsushi Yoshita, Yasuyuki Nakamura, Nagako Okuda, Nobuo Nishi, Yoshihiro Miyamoto, Hisatomi Arima, Takayoshi Ohkubo, Tomonori Okamura, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura

    Journal of epidemiology　28 Suppl 3　S17-S22　2018

    DOI： 10.2188/jea.JE20170250 　

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    BACKGROUND: This study examined the relationships among household income, other SES indicators, and macronutrient intake in a cross-sectional study of a representative Japanese population. METHODS: In 2010, we established a cohort of participants in the National Health and Nutrition Survey (NHNS) from 300 randomly selected areas throughout Japan. A total of 2,637 participants (1,145 men and 1,492 women) were included in the study. Data from NHNS2010 and the Comprehensive Survey of Living Conditions 2010 (CSCL2010) were merged, and relationships among macronutrient intake and SES were evaluated. Additionally, socioeconomic factors associated with a risk of a higher carbohydrate/lower fat intake beyond dietary recommendations were evaluated. RESULTS: Household income was positively associated with fat intake (P = 0.001 for men and <0.001 for women) and inversely associated with carbohydrate intake (P = 0.003 for men and <0.001 for women) after adjustments for age and other SES variables. Similar relationships were observed between equivalent household expenditure (EHE) and macronutrient intake; however, these relationships were weaker than those of household income. Older age was the factor most strongly associated with a high carbohydrate/low fat intake, followed by household income, EHE, education levels, and occupation type. CONCLUSIONS: Older age was the factor most strongly associated with a high carbohydrate/low fat intake, and some aspects of SES, such as household income, EHE, education levels, and occupation type, were independently associated with an imbalanced macronutrient intake. SES may affect the health status of individuals through the intake of macronutrients.

  346. Relationships among Food Group Intakes, Household Expenditure, and Education Attainment in a General Japanese Population: NIPPON DATA2010.

    Tomomi Nagahata, Mieko Nakamura, Toshiyuki Ojima, Imako Kondo, Toshiharu Ninomiya, Katsushi Yoshita, Yusuke Arai, Takayoshi Ohkubo, Keiko Murakami, Nobuo Nishi, Yoshitaka Murakami, Naoyuki Takashima, Nagako Okuda, Aya Kadota, Naoko Miyagawa, Keiko Kondo, Tomonori Okamura, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura

    Journal of epidemiology　28 Suppl 3　S23-S28　2018

    DOI： 10.2188/jea.JE20170248 　

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    BACKGROUND: A lower socioeconomic status (SES) may be related to the intake of unhealthy food; however, this relationship has not been examined in detail. This study was undertaken to examine relationships among food group intakes and SES in a representative Japanese population. METHODS: This was a cross-sectional study using the baseline data of NIPPON DATA2010, which is a prospective cohort study of the National Health and Nutrition Survey in Japan. A total of 2,898 participants were included in the baseline survey in 2010. The effects of age (<65 years and ≥65 years), equivalent household expenditure (EHE), and education attainment on food group intakes (gram per 1,000 kcal) were analyzed using a two-way analysis of variance. RESULTS: When EHE was lower, cereal intake was higher in men and women. Among men, fish, milk, and alcohol intakes were reduced with lower EHE. Among women, vegetable intake was reduced with lower EHE. In men and women, cereal intake was higher with lower education attainment. In contrast, meat intake was reduced with lower education attainment. CONCLUSIONS: Lower SES was associated with a higher cereal intake and lower vegetable, fish, meat, and milk intakes in a representative Japanese population. Socioeconomic discrepancies need to be considered in order to promote healthier dietary habits.

  347. Differences in Lifestyle Improvements With the Intention to Prevent Cardiovascular Diseases by Socioeconomic Status in a Representative Japanese Population: NIPPON DATA2010. Peer-reviewed

    Goryoda S, Nishi N, Hozawa A, Yoshita K, Arai Y, Kondo K, Miyagawa N, Hayakawa T, Fujiyoshi A, Kadota A, Ohkubo T, Okamura T, Okuda N, Ueshima H, Okayama A, Miura K

    Journal of epidemiology　28 Suppl 3　S35-S39　2018

    DOI： 10.2188/jea.JE20170254 　

    ISSN： 0917-5040

  348. Factors Related to Participation in Health Examinations for Japanese National Health Insurance: NIPPON DATA2010. Peer-reviewed

    Imamura H, Kogure M, Kita Y, Nakagawa H, Hozawa A, Okamura T, Murakami Y, Nishi N, Okuda N, Kadota A, Ohkubo T, Ueshima H, Okayama A, Miura K

    Journal of epidemiology　28 Suppl 3　S53-S58　2018

    DOI： 10.2188/jea.JE20170251 　

    ISSN： 0917-5040

  349. Association between mild physical injury and psychological distress: Shichigahama Health Promotion Project Peer-reviewed

    NARITA Akira, NAKAYA Naoki, NAKAMURA Tomohiro, TSUCHIYA Naho, KOGURE Mana, TSUJI Ichiro, HOZAWA Atsushi, TOMITA Hiroaki

    Nihon Koshu Eisei Zasshi(JAPANESE JOURNAL OF PUBLIC HEALTH)　65　(4)　157-163　2018

    Publisher: Japanese Society of Public Health

    DOI： 10.11236/jph.65.4_157 　

    ISSN： 0546-1766

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    <p>Objective Although a number of previous studies have investigated the association between natural disaster-related physical injury and mental health, very few have focused on mild physical injury. The aim of this study was to evaluate the association between natural disaster-related mild physical injury and psychological distress in a cross-sectional study.</p><p>Method This study is a part of the Shichigahama Health Promotion Project, which was conducted in cooperation with the Tohoku University and Shichigahama Town, Miyagi Prefecture, after the Great East Japan Earthquake (GEJE). We conducted the research about one year after the GEJE, and performed logistic regression analyses using 3,844 participants (1,821 males/2,023 females) aged 20 years or older, who answered all the questions on physical injuries and the Kessler 6 scale (K6), after adjusting for gender, age, social factors, and lifestyles. Psychological distress was defined as a K6 score ≥ 13 out of 24 points. We also investigated the effect of other disaster situations on the association between mild physical injury and psychological distress by stratifying the dataset by bereavement, witnessing someone's death, and house damage.</p><p>Results The participants with physical injury were at a significantly higher risk of psychological distress, with an adjusted odds ratio (aOR) of 2.05 and 95% confidence interval (CI) of 1.26-3.34, than those uninjured. Additionally, the participants with mild physical injury were at a significantly higher risk of psychological distress (aOR=2.18, 95% CI=1.32-3.59). In the subgroup of participants with small-scale house damage, mild physical injury was significantly associated with psychological distress with an aOR of 4.01 and 95% CI of 2.03-7.93, whereas not in the subgroup of those with large-scale house damage, and a significant interaction was detected between mild physical injury and house damage.</p><p>Conclusion We investigated the association between natural disaster-related physical injury and psychological distress in a cohort of approximately 4,000 residents in an area devastated by the GEJE. In this study, natural disaster-related physical injury was positively associated with psychological distress. The finding indicates that even mild physical injury can be an indicator of high risk for psychological distress.</p>

  350. Population-based biobank participants' preferences for receiving genetic test results Peer-reviewed

    Kayono Yamamoto, Tsuyoshi Hachiya, Akimune Fukushima, Naoki Nakaya, Akira Okayama, Kozo Tanno, Fumie Aizawa, Tomoharu Tokutomi, Atsushi Hozawa, Atsushi Shimizu

    JOURNAL OF HUMAN GENETICS　62　(12)　1037-1048　2017/12

    DOI： 10.1038/jhg.2017.81 　

    ISSN： 1434-5161

    eISSN： 1435-232X

  351. Genome-wide meta-analysis in Japanese populations identifies novel variants at the TMC6-TMC8 and SIX3-SIX2 loci associated with HbA(1c) Peer-reviewed

    Tsuyoshi Hachiya, Shohei Komaki, Yutaka Hasegawa, Hideki Ohmomo, Kozo Tanno, Atsushi Hozawa, Gen Tamiya, Masayuki Yamamoto, Kuniaki Ogasawara, Motoyuki Nakamura, Jiro Hitomi, Yasushi Ishigaki, Makoto Sasaki, Atsushi Shimizu

    SCIENTIFIC REPORTS　7　(1)　16147　2017/11

    DOI： 10.1038/s41598-017-16493-0 　

    ISSN： 2045-2322

  352. Genome-wide association study identifies 112 new loci for body mass index in the Japanese population Peer-reviewed

    Masato Akiyama, Yukinori Okada, Masahiro Kanai, Atsushi Takahashi, Yukihide Momozawa, Masashi Ikeda, Nakao Iwata, Shiro Ikegawa, Makoto Hirata, Koichi Matsuda, Motoki Iwasaki, Taiki Yamaji, Norie Sawada, Tsuyoshi Hachiya, Kozo Tanno, Atsushi Shimizu, Atsushi Hozawa, Naoko Minegishi, Shoichiro Tsugane, Masayuki Yamamoto, Michiaki Kubo, Yoichiro Kamatani

    NATURE GENETICS　49　(10)　1458-+　2017/10

    DOI： 10.1038/ng.3951 　

    ISSN： 1061-4036

    eISSN： 1546-1718

  353. Predictive ability of a simple subjective memory complaints scale for incident dementia: Evaluation of Japan's national checklist, the "Kihon Checklist" Peer-reviewed

    Yasutake Tomata, Kemmyo Sugiyama, Yu Kaiho, Yumi Sugawara, Atsushi Hozawa, Ichiro Tsuji

    GERIATRICS & GERONTOLOGY INTERNATIONAL　17　(9)　1300-1305　2017/09

    DOI： 10.1111/ggi.12864 　

    ISSN： 1444-1586

    eISSN： 1447-0594

  354. Bloodpressure, heart rate, anddouble product in a pooled cohort: the Japan Arteriosclerosis Longitudinal Study Peer-reviewed

    Kei Asayama, Atsushi Hozawa, Masataka Taguri, Takayoshi Ohkubo, Yasuharu Tabara, Kazuo Suzuki, Takashi Ando, Akiko Harada, Yasuo Ohashi, Hirotsugu Ueshima, Hideaki Toyoshima, Yutaka Imai

    JOURNAL OF HYPERTENSION　35　(9)　1808-1815　2017/09

    DOI： 10.1097/HJH.0000000000001399 　

    ISSN： 0263-6352

    eISSN： 1473-5598

  355. Psychological Distress among Individuals Whose Partners Have Cancer Peer-reviewed

    Naoki Nakaya, Toshimasa Sone, Kumi Nakaya, Yasutake Tomata, Atsushi Hozawa, Ichiro Tsuji

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　243　(1)　27-33　2017/09

    DOI： 10.1620/tjem.243.27 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  356. Coffee Consumption and Mortality Due to All Causes, Cardiovascular Disease, and Cancer in Japanese Women Peer-reviewed

    Kemmyo Sugiyama, Shinichi Kuriyama, Munira Akhter, Masako Kakizaki, Naoki Nakaya, Kaori Ohmori-Matsuda, Taichi Shimazu, Masato Nagai, Yumi Sugawara, Atsushi Hozawa, Akira Fukao, Ichiro Tsuji

    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY　313　(1)　1007-1013　2017/07

    DOI： 10.3945/jn.109.109314 　

    ISSN： 1040-0605

    eISSN： 1522-1504

  357. Development of a Questionnaire Method of Screening for Citrin Deficiency in Schoolchildren Peer-reviewed

    Miyashita M, Ishikuro M, Kikuya M, Yamanaka C, Mizuno S, Nagai M, Sato Y, Obara T, Metoki H, Kikuchi A, Nakaya N, Hozawa A, Tsuji I, Yaegashi N, Yamamoto M, Kure S, Kuriyama S

    Journal of Pediatrics and Congenital Disorders　4　101　2017/07

  358. Security controls in an integrated Biobank to protect privacy in data sharing: rationale and study design Peer-reviewed

    Takako Takai-Igarashi, Kengo Kinoshita, Masao Nagasaki, Soichi Ogishima, Naoki Nakamura, Sachiko Nagase, Satoshi Nagaie, Tomo Saito, Fuji Nagami, Naoko Minegishi, Yoichi Suzuki, Kichiya Suzuki, Hiroaki Hashizume, Shinichi Kuriyama, Atsushi Hozawa, Nobuo Yaegashi, Shigeo Kure, Gen Tamiya, Yoshio Kawaguchi, Hiroshi Tanaka, Masayuki Yamamoto

    BMC MEDICAL INFORMATICS AND DECISION MAKING　17　(1)　100　2017/07

    DOI： 10.1186/s12911-017-0494-5 　

    ISSN： 1472-6947

  359. Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases Peer-reviewed

    Tetsuro Matsuhashi, Takeya Sato, Shin-ichiro Kanno, Takehiro Suzuki, Akihiro Matsuo, Yuki Oba, Motoi Kikusato, Emi Ogasawara, Tai Kudo, Kosuke Suzuki, Osamu Ohara, Hiroko Shimbo, Fumika Nanto, Hiroaki Yamaguchi, Daisuke Saigusa, Yasuno Mukaiyama, Akiko Watabe, Koichi Kikuchi, Hisato Shima, Eikan Mishima, Yasutoshi Akiyama, Yoshitsugu Oikawa, Hsin-Jung Ho, Yukako Akiyama, Chitose Suzuki, Mitsugu Uematsu, Masaki Ogata, Naonori Kumagai, Masaaki Toyomizu, Atsushi Hozawa, Nariyasu Mano, Yuji Owada, Setsuya Aiba, Teruyuki Yanagisawa, Yoshihisa Tomioka, Shigeo Kure, Sadayoshi Ito, Kazuto Nakada, Ken-ichiro Hayashi, Hitoshi Osaka, Takaaki Abe

    EBIOMEDICINE　20　27-38　2017/06

    DOI： 10.1016/j.ebiom.2017.05.016 　

    ISSN： 2352-3964

  360. Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes. International-journal Peer-reviewed

    Masahiro Nezu, Tomokazu Souma, Lei Yu, Hiroki Sekine, Nobuyuki Takahashi, Andrew Zu-Sern Wei, Sadayoshi Ito, Akiyoshi Fukamizu, Zsuzsanna K Zsengeller, Tomohiro Nakamura, Atsushi Hozawa, S Ananth Karumanchi, Norio Suzuki, Masayuki Yamamoto

    Science signaling　10　(479)　2017/05/16

    DOI： 10.1126/scisignal.aam5711 　

    ISSN： 1945-0877

  361. Outcome-Driven Thresholds for Increased Home Blood Pressure Variability Peer-reviewed

    Eeva P. Juhanoja, Teemu J. Niiranen, Jouni K. Johansson, Pauli J. Puukka, Lutgarde Thijs, Kei Asayama, Ville L. Langen, Atsushi Hozawa, Lucas S. Aparicio, Takayoshi Ohkubo, Ichiro Tsuji, Yutaka Imai, George S. Stergiou, Antti M. Jula, Jan A. Staessen

    HYPERTENSION　69　(4)　599-607　2017/04

    DOI： 10.1161/HYPERTENSIONAHA.116.08603 　

    ISSN： 0194-911X

    eISSN： 1524-4563

  362. Psychological Distress and the Risk of Withdrawing From Hypertension Treatment After an Earthquake Disaster Peer-reviewed

    Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

    DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS　11　(2)　179-182　2017/04

    DOI： 10.1017/dmp.2016.102 　

    ISSN： 1935-7893

    eISSN： 1938-744X

  363. The Association Between the History of Hypertensive Disorders of Pregnancy, Obesity and Hypertension in Later Life by Age Group: A Cross-Sectional Analysis. Peer-reviewed

    Maiko Wagata, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Hirohito Metoki, Akimune Fukushima, Nobuo Yaegashi, Shigeo Kure, Shinichi Kuriyama, Atsushi Hozawa, Junichi Sugawara

    REPRODUCTIVE SCIENCES　24　63A-63A　2017/03

    ISSN： 1933-7191

    eISSN： 1933-7205

  364. Genetic Predisposition to Ischemic Stroke: A Polygenic Risk Score Peer-reviewed

    Tsuyoshi Hachiya, Yoichiro Kamatani, Atsushi Takahashi, Jun Hata, Ryohei Furukawa, Yuh Shiwa, Taiki Yamaji, Megumi Hara, Kozo Tanno, Hideki Ohmomo, Kanako Ono, Naoyuki Takashima, Koichi Matsuda, Kenji Wakai, Norie Sawada, Motoki Iwasaki, Kazumasa Yamagishi, Tetsuro Ago, Toshiharu Ninomiya, Akimune Fukushima, Atsushi Hozawa, Naoko Minegishi, Mamoru Satoh, Ryujin Endo, Makoto Sasaki, Kiyomi Sakata, Seiichiro Kobayashi, Kuniaki Ogasawara, Motoyuki Nakamura, Jiro Hitomi, Yoshikuni Kita, Keitaro Tanaka, Hiroyasu Iso, Takanari Kitazono, Michiaki Kubo, Hideo Tanaka, Shoichiro Tsugane, Yutaka Kiyohara, Masayuki Yamamoto, Kenji Sobue, Atsushi Shimizu

    STROKE　48　(2)　253-258　2017/02

    DOI： 10.1161/STROKEAHA.116.014506 　

    ISSN： 0039-2499

    eISSN： 1524-4628

  365. Regional colorectal cancer screening program using colonoscopy on an island: a prospective Nii-jima study Peer-reviewed

    Kinichi Hotta, Takahisa Matsuda, Yasuo Kakugawa, Hiroaki Ikematsu, Nozomu Kobayashi, Ryoji Kushima, Atsushi Hozawa, Takeshi Nakajima, Taku Sakamoto, Mika Mori, Takahiro Fujii, Yutaka Saito

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY　47　(2)　118-122　2017/02

    DOI： 10.1093/jjco/hyw155 　

    ISSN： 0368-2811

    eISSN： 1465-3621

  366. NIPPON DATAイベント判定委員会

    -　21-24　2017

  367. IRON INTAKE ASSOCIATED WITH SOCIAL FACTORS AMONG WOMEN OF REPRODUCTIVE AGE IN JAPAN: FINDINGS FROM THE NIPPON DATA2010 Peer-reviewed

    Chisa Shinsugi, Nobuo Nishi, Aya Kadota, Atsushi Hozawa, Takayoshi Ohkubo, Nagako Okuda, Tomonori Okamura, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura

    ANNALS OF NUTRITION AND METABOLISM　71　738-738　2017

    ISSN： 0250-6807

    eISSN： 1421-9697

  368. Monitoring of minimal residual disease in early T-cell precursor acute lymphoblastic leukaemia by next-generation sequencing Peer-reviewed

    Xiaoqing Pan, Naoki Nariai, Noriko Fukuhara, Sakae Saito, Yukuto Sato, Fumiki Katsuoka, Kaname Kojima, Yoko Kuroki, Inaho Danjoh, Rumiko Saito, Shin Hasegawa, Yoko Okitsu, Aiko Kondo, Yasushi Onishi, Fuji Nagami, Hideyasu Kiyomoto, Atsushi Hozawa, Nobuo Fuse, Masao Nagasaki, Ritsuko Shimizu, Jun Yasuda, Hideo Harigae, Masayuki Yamamoto

    BRITISH JOURNAL OF HAEMATOLOGY　176　(2)　318-321　2017/01

    DOI： 10.1111/bjh.13948 　

    ISSN： 0007-1048

    eISSN： 1365-2141

  369. Impact of social capital on psychological distress and interaction with house destruction and displacement after the Great East Japan Earthquake of 2011 Peer-reviewed

    Naho Tsuchiya, Naoki Nakaya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Jun Aida, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

    PSYCHIATRY AND CLINICAL NEUROSCIENCES　71　(1)　52-60　2017/01

    DOI： 10.1111/pcn.12467 　

    ISSN： 1323-1316

    eISSN： 1440-1819

  370. OUTCOME-DRIVEN REFERENCE FRAME FOR SELF-MEASURED HOME BLOOD PRESSURE VARIABILITY: INTERNATIONAL DATABASE OF HOME BLOOD PRESSURE IN RELATION TO CARDIOVASCULAR OUTCOME (IDHOCO) Peer-reviewed

    Juhanoja Eeva, Johansson Jouni, Thijs Lutgarde, Asayama Kei, Hozawa Atsushi, Ohkubo Takayoshi, Stergiou George, Tsuji Ichiro, Imai Yutaka, Jula Antti, Niiranen Teemu, Staessen Jan

    JOURNAL OF HYPERTENSION　34　E36　2016/09

    DOI： 10.1097/01.hjh.0000499951.86351.ac 　

    ISSN： 0263-6352

  371. Does the flushing response modify the relationship between alcohol intake and hypertension in the Japanese population? NIPPON DATA2010 Peer-reviewed

    Mana Kogure, Naho Tsuchiya, Atsushi Hozawa, Naoki Nakaya, Tomohiro Nakamura, Naomi Miyamatsu, Hideo Tanaka, Ichiro Wakabayashi, Aya Higashiyama, Nagako Okuda, Naoyuki Takashima, Akira Fujiyoshi, Aya Kadota, Takayoshi Ohkubo, Tomonori Okamura, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura

    HYPERTENSION RESEARCH　39　(9)　670-679　2016/09

    DOI： 10.1038/hr.2016.46 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  372. The Tohoku Medical Megabank Project: Design and Mission Peer-reviewed

    Shinichi Kuriyama, Nobuo Yaegashi, Fuji Nagami, Tomohiko Arai, Yoshio Kawaguchi, Noriko Osumi, Masaki Sakaida, Yoichi Suzuki, Keiko Nakayama, Hiroaki Hashizume, Gen Tamiya, Hiroshi Kawame, Kichiya Suzuki, Atsushi Hozawa, Naoki Nakaya, Masahiro Kikuya, Hirohito Metoki, Ichiro Tsuji, Nobuo Fuse, Hideyasu Kiyomoto, Junichi Sugawara, Akito Tsuboi, Shinichi Egawa, Kiyoshi Ito, Koichi Chida, Tadashi Ishii, Hiroaki Tomita, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Seizo Koshiba, Kengo Kinoshita, Soichi Ogishima, Takako Takai-Igarashi, Teiji Tominaga, Osamu Tanabe, Noriaki Ohuchi, Toru Shimosegawa, Shigeo Kure, Hiroshi Tanaka, Sadayoshi Ito, Jiro Hitomi, Kozo Tanno, Motoyuki Nakamura, Kuniaki Ogasawara, Seiichiro Kobayashi, Kiyomi Sakata, Mamoru Satoh, Atsushi Shimizu, Makoto Sasaki, Ryujin Endo, Kenji Sobue, Masayuki Yamamoto

    JOURNAL OF EPIDEMIOLOGY　26　(9)　493-511　2016/09

    DOI： 10.2188/jea.JE20150268 　

    ISSN： 0917-5040

  373. Relationship between office and home blood pressure with increasing age: The International Database of HOme blood pressure in relation to Cardiovascular Outcome (IDHOCO) Peer-reviewed

    Angeliki Ntineri, George S. Stergiou, Lutgarde Thijs, Kei Asayama, Jose Boggia, Nadia Boubouchairopoulou, Atsushi Hozawa, Yutaka Imai, Jouni K. Johansson, Antti M. Jula, Anastasios Kollias, Leonella Luzardo, Teemu J. Niiranen, Kyoko Nomura, Takayoshi Ohkubo, Ichiro Tsuji, Christophe Tzourio, Fang-Fei Wei, Jan A. Staessen

    HYPERTENSION RESEARCH　39　(8)　612-617　2016/08

    DOI： 10.1038/hr.2016.32 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  374. Partners' Ongoing Treatment for Chronic Disease and the Risk of Psychological Distress after the Great East Japan Earthquake Peer-reviewed

    Naoki Nakaya, Akira Narita, Naho Tsuchiya, Tomohiro Nakamura, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　239　(4)　307-314　2016/08

    DOI： 10.1620/tjem.239.307 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  375. The structural origin of metabolic quantitative diversity Peer-reviewed

    Seizo Koshiba, Ikuko Motoike, Kaname Kojima, Takanori Hasegawa, Matsuyuki Shirota, Tomo Saito, Daisuke Saigusa, Inaho Danjoh, Fumiki Katsuoka, Soichi Ogishima, Yosuke Kawai, Yumi Yamaguchi-Kabata, Miyuki Sakurai, Sachiko Hirano, Junichi Nakata, Hozumi Motohashi, Atsushi Hozawa, Shinichi Kuriyama, Naoko Minegishi, Masao Nagasaki, Takako Takai-Igarashi, Nobuo Fuse, Hideyasu Kiyomoto, Junichi Sugawara, Yoichi Suzuki, Shigeo Kure, Nobuo Yaegashi, Osamu Tanabe, Kengo Kinoshita, Jun Yasuda, Masayuki Yamamoto

    SCIENTIFIC REPORTS　6　31463　2016/08

    DOI： 10.1038/srep31463 　

    ISSN： 2045-2322

  376. Public Attitudes toward an Epidemiological Study with Genomic Analysis in the Great East Japan Earthquake Disaster Area Peer-reviewed

    Mami Ishikuro, Naoki Nakaya, Taku Obara, Yuki Sato, Hirohito Metoki, Masahiro Kikuya, Naho Tsuchiya, Tomohiro Nakamura, Fuji Nagami, Shinichi Kuriyama, Atsushi Hozawa

    PREHOSPITAL AND DISASTER MEDICINE　31　(3)　330-334　2016/06

    DOI： 10.1017/S1049023X16000182 　

    ISSN： 1049-023X

    eISSN： 1945-1938

  377. Prospect of future housing and risk of psychological distress at 1 year after an earthquake disaster Peer-reviewed

    Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

    PSYCHIATRY AND CLINICAL NEUROSCIENCES　70　(4)　182-189　2016/04

    DOI： 10.1111/pcn.12377 　

    ISSN： 1323-1316

    eISSN： 1440-1819

  378. Is Home Blood Pressure More Strongly Associated with Coronary Artery Calcification Than Clinic Blood Pressure Measured Under an Appropriate Condition? Peer-reviewed

    Atsushi Satoh, Hisatomi Arima, Atsushi Hozawa, Takashi Hisamatsu, Sayaka Kadowaki, Aya Kadota, Akira Fujiyoshi, Naoko Miyagawa, Maryam Zaid, Sayuki Torii, Takayoshi Ohkubo, Tomonori Okamura, Akira Sekikawa, Katsuyuki Miura, Hirotsugu Ueshima

    CIRCULATION　133　2016/03

    ISSN： 0009-7322

    eISSN： 1524-4539

  379. Association of Total Energy Intake with 29-Year Mortality in the Japanese: NIPPON DATA80. Peer-reviewed

    Masato Nagai, Takayoshi Ohkubo, Katsuyuki Miura, Akira Fujiyoshi, Nagako Okuda, Takehito Hayakawa, Katsushi Yoshita, Yusuke Arai, Hideaki Nakagawa, Koshi Nakamura, Naoko Miyagawa, Naoyuki Takashima, Aya Kadota, Yoshitaka Murakami, Yasuyuki Nakamura, Robert D Abbott, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima

    Journal of atherosclerosis and thrombosis　23　(3)　339-54　2016

    DOI： 10.5551/jat.29991 　

    More details Close

    AIM: In animals, dietary energy restriction is reported to increase longevity, whereas in humans, all cohort studies from Western countries have not shown an association between the low energy intake and longevity. We examined the association between total energy intake and longevity in Japan where dietary pattern is different from that in the West. METHODS: A total of 7,704 Japanese aged 30-69 years were followed from 1980 to 2009. Participants were divided into the quintiles of total energy (kcal/day) based on data collected from the National Nutrition Survey. Hazard ratios and 95% confidence intervals (CIs) were derived through the use of Cox proportional hazards models to compare the risk of death across and between the quintiles. RESULTS: There was a significant association between increased energy intake and all-cause mortality risk in only men (P for linear trend=0.008). In cause-specific analysis, compared with the lowest quintile, there was rise in coronary heart disease (CHD) mortality among men (HR; 2.63, 95%CI; 0.95-7.28, P for linear trend 0.016) and women (HR; 2.91, 95%CI; 1.02-8.29, P for linear trend 0.032) and cancer mortality among men (HR; 1.50, 95%CI; 0.999-2.24, P for linear trend 0.038) in the top quintile. CONCLUSION: We observed significant associations of high energy intake with all-cause and cancer mortality among men and with CHD mortality among men and women. Further studies are needed to confirm the benefits of caloric restriction.

  380. Adjustment of Cell-Type Composition Minimizes Systematic Bias in Blood DNA Methylation Profiles Derived by DNA Collection Protocols Peer-reviewed

    Yuh Shiwa, Tsuyoshi Hachiya, Ryohei Furukawa, Hideki Ohmomo, Kanako Ono, Hisaaki Kudo, Jun Hata, Atsushi Hozawa, Motoki Iwasaki, Koichi Matsuda, Naoko Minegishi, Mamoru Satoh, Kozo Tanno, Taiki Yamaji, Kenji Wakai, Jiro Hitomi, Yutaka Kiyohara, Michiaki Kubo, Hideo Tanaka, Shoichiro Tsugane, Masayuki Yamamoto, Kenji Sobue, Atsushi Shimizu

    PLOS ONE　11　(1)　e0147519　2016/01

    DOI： 10.1371/journal.pone.0147519 　

    ISSN： 1932-6203

  381. Whole-genome Japanese Reference Panel and future directions Peer-reviewed

    Masao Nagasaki, Jun Yasuda, Fumiki Katsuoka, Naoki Nariai, Kaname Kojima, Yosuke Kawai, Yumi Yamaguchi-Kabata, Junji Yokozawa, Inaho Danjoh, Sakae Saito, Yukuto Sato, Takahiro Mimori, Kaoru Tsuda, Rumiko Saito, Pan Xiaoqing, Satoshi Nishikawa, Shin Ito, Yoko Kuroki, Osamu Tanabe, Nobuo Fuse, Shinichi Kuriyama, Hideyasu Kiyomoto, Atsushi Hozawa, Naoko Minegishi, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto

    GENES & GENETIC SYSTEMS　90　(6)　377-377　2015/12

    ISSN： 1341-7568

    eISSN： 1880-5779

  382. Eczema and Asthma Symptoms among Schoolchildren in Coastal and Inland Areas after the 2011 Great East Japan Earthquake: The ToMMo Child Health Study Peer-reviewed

    Masako Miyashita, Masahiro Kikuya, Chizuru Yamanaka, Mami Ishikuro, Taku Obara, Yuki Sato, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Hideyasu Kiyomoto, Junichi Sugawara, Atsushi Hozawa, Nobuo Fuse, Yoichi Suzuki, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　237　(4)　297-305　2015/12

    DOI： 10.1620/tjem.237.297 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  383. The Association Between Medical Treatment of Physical Diseases and Psychological Distress After the Great East Japan Earthquake: The Shichigahama Health Promotion Project Peer-reviewed

    Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita

    DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS　9　(4)　374-381　2015/08

    DOI： 10.1017/dmp.2015.52 　

    ISSN： 1935-7893

    eISSN： 1938-744X

  384. Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals Peer-reviewed

    Masao Nagasaki, Jun Yasuda, Fumiki Katsuoka, Naoki Nariai, Kaname Kojima, Yosuke Kawai, Yumi Yamaguchi-Kabata, Junji Yokozawa, Inaho Danjoh, Sakae Saito, Yukuto Sato, Takahiro Mimori, Kaoru Tsuda, Rumiko Saito, Xiaoqing Pan, Satoshi Nishikawa, Shin Ito, Yoko Kuroki, Osamu Tanabe, Nobuo Fuse, Shinichi Kuriyama, Hideyasu Kiyomoto, Atsushi Hozawa, Naoko Minegishi, James Douglas Engel, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto

    NATURE COMMUNICATIONS　6　8018　2015/08

    DOI： 10.1038/ncomms9018 　

    ISSN： 2041-1723

  385. Protocol and Research Perspectives of the ToMMo Child Health Study after the 2011 Great East Japan Earthquake Peer-reviewed

    Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, Yuki Sato, Taku Obara, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Hideyasu Kiyomoto, Junichi Sugawara, Atsushi Hozawa, Nobuo Fuse, Yoichi Suzuki, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　236　(2)　123-130　2015/06

    DOI： 10.1620/tjem.236.123 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  386. Optimal Number of Days for Home Blood Pressure Measurement Peer-reviewed

    Teemu J. Niiranen, Kei Asayama, Lutgarde Thijs, Jouni K. Johansson, Azusa Hara, Atsushi Hozawa, Ichiro Tsuji, Takayoshi Ohkubo, Antti M. Jula, Yutaka Imai, Jan A. Staessen

    AMERICAN JOURNAL OF HYPERTENSION　28　(5)　595-603　2015/05

    DOI： 10.1093/ajh/hpu216 　

    ISSN： 0895-7061

    eISSN： 1941-7225

  387. Effects of a long-term intervention in a work cafeteria on employee vegetable intake

    Akemi Misawa, Katsushi Yoshita, Tomoe Fukumura, Taichiro Tanaka, Junko Tamaki, Toru Takebayashi, Yukinori Kusaka, Hideaki Nakagawa, Hiroshi Yamato, Akira Okayama, Katsuyuki Miura, Tomonori Okamura, Hirotsugu Ueshima

    Sangyō eiseigaku zasshi = Journal of occupational health　57　97-107　2015/01/01

    Publisher: Japan Society for Occupational Health

    DOI： 10.1539/sangyoeisei.B14017 　

    ISSN： 1341-0725

  388. Slight increase in urinary albumin excretion within the normal range predicts incident hypertension in a community-based Japanese population: the Takahata study Peer-reviewed

    Atsushi Hirayama, Tsuneo Konta, Atsushi Hozawa, Ryo Kawasaki, Tetsu Watanabe, Yoko Shibata, Takamasa Kayama, Akira Fukao, Isao Kubota

    HYPERTENSION RESEARCH　38　(1)　56-60　2015/01

    DOI： 10.1038/hr.2014.117 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  389. Risk of Hypercholesterolemia for Cardiovascular Disease and the Population Attributable Fraction in a 24-year Japanese Cohort Study Peer-reviewed

    Daisuke Sugiyama, Tomonori Okamura, Makoto Watanabe, Aya Higashiyama, Nagako Okuda, Yasuyuki Nakamura, Atsushi Hozawa, Yoshikuni Kita, Aya Kadota, Yoshitaka Murakami, Naomi Miyamatsu, Takayoshi Ohkubo, Takehito Hayakawa, Yoshihiro Miyamoto, Katsuyuki Miura, Akira Okayama, Hirotsugu Ueshima

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS　22　(1)　95-107　2015

    DOI： 10.5551/jat.25908 　

    ISSN： 1340-3478

    eISSN： 1880-3873

  390. Participants with Treated Hyperlipidemia may be More Health Conscious Peer-reviewed

    Atsushi Hozawa, Tomonori Okamura

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS　22　(10)　1025-1026　2015

    DOI： 10.5551/jat.ED021 　

    ISSN： 1340-3478

    eISSN： 1880-3873

  391. Streamlining of medical relief to areas affected by the Great East Japan earthquake with the "area-based/line-linking support system". International-journal Peer-reviewed

    Satoshi Yamanouchi, Tadashi Ishii, Kazuma Morino, Hajime Furukawa, Atsushi Hozawa, Sae Ochi, Shigeki Kushimoto

    Prehospital and disaster medicine　29　(6)　614-22　2014/12

    DOI： 10.1017/S1049023X14001095 　

    ISSN： 1049-023X

    More details Close

    INTRODUCTION: When disasters that affect a wide area occur, external medical relief teams play a critical role in the affected areas by helping to alleviate the burden caused by surging numbers of individuals requiring health care. Despite this, no system has been established for managing deployed medical relief teams during the subacute phase following a disaster. After the Great East Japan Earthquake and tsunami, the Ishinomaki Medical Zone was the most severely-affected area. Approximately 6,000 people died or were missing, and the immediate evacuation of approximately 120,000 people to roughly 320 shelters was required. As many as 59 medical teams came to participate in relief activities. Daily coordination of activities and deployment locations became a significant burden to headquarters. The Area-based/Line-linking Support System (Area-Line System) was thus devised to resolve these issues for medical relief and coordinating activities. METHODS: A retrospective analysis was performed to examine the effectiveness of the medical relief provided to evacuees using the Area-Line System with regards to the activities of the medical relief teams and the coordinating headquarters. The following were compared before and after establishment of the Area-Line System: (1) time required at the coordinating headquarters to collect and tabulate medical records from shelters visited; (2) time required at headquarters to determine deployment locations and activities of all medical relief teams; and (3) inter-area variation in number of patients per team. RESULTS: The time required to collect and tabulate medical records was reduced from approximately 300 to 70 minutes/day. The number of teams at headquarters required to sort through data was reduced from 60 to 14. The time required to determine deployment locations and activities of the medical relief teams was reduced from approximately 150 hours/month to approximately 40 hours/month. Immediately prior to establishment of the Area-Line System, the variation of the number of patients per team was highest. Variation among regions did not increase after establishment of the system. CONCLUSION: This descriptive analysis indicated that implementation of the Area-Line System, a systematic approach for long-term disaster medical relief across a wide area, can increase the efficiency of relief provision to disaster-stricken areas.

  392. Thresholds for Conventional and Home Blood Pressure by Sex and Age in 5018 Participants From 5 Populations Peer-reviewed

    Kyoko Nomura, Kei Asayama, Lutgarde Thijs, Teemu J. Niiranen, Ines Lujambio, Jose Boggia, Atsushi Hozawa, Takayoshi Ohkubo, Azusa Hara, Jouni K. Johansson, Edgardo Sandoya, Anastasios Kollias, George S. Stergiou, Ichiro Tsuji, Antti M. Jula, Yutaka Imai, Jan A. Staessen

    HYPERTENSION　64　(4)　695-+　2014/10

    DOI： 10.1161/HYPERTENSIONAHA.114.03839 　

    ISSN： 0194-911X

    eISSN： 1524-4563

  393. Reference frame for home pulse pressure based on cardiovascular risk in 6470 subjects from 5 populations Peer-reviewed

    Lucas S. Aparicio, Lutgarde Thijs, Kei Asayama, Jessica Barochiner, Jose Boggia, Yu-Mei Gu, Paula E. Cuffaro, Yan-Ping Liu, Teemu J. Niiranen, Takayoshi Ohkubo, Jouni K. Johansson, Masahiro Kikuya, Atsushi Hozawa, Ichiro Tsuji, Yutaka Imai, Edgardo Sandoya, George S. Stergiou, Gabriel D. Waisman, Jan A. Staessen

    HYPERTENSION RESEARCH　37　(7)　672-678　2014/07

    DOI： 10.1038/hr.2014.45 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  394. Serum Adiponectin and Poor Physical Fitness in the Community-Dwelling Elderly Peer-reviewed

    Cong Huang, Atsushi Hozawa, Yasutake Tomata, Masako Kakizaki, Yumi Sugawara, Haruki Momma, Ichiro Tsuji, Ryoichi Nagatomi

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE　46　(5)　654-654　2014/05

    DOI： 10.1249/01.mss.0000495432.12708.fd 　

    ISSN： 0195-9131

    eISSN： 1530-0315

  395. Prognosis of White-Coat and Masked Hypertension International Database of Home Blood Pressure in Relation to Cardiovascular Outcome Peer-reviewed

    George S. Stergiou, Kei Asayama, Lutgarde Thijs, Anastasios Kollias, Teemu J. Niiranen, Atsushi Hozawa, Jose Boggia, Jouni K. Johansson, Takayoshi Ohkubo, Ichiro Tsuji, Antti M. Jula, Yutaka Imai, Jan A. Staessen

    HYPERTENSION　63　(4)　675-682　2014/04

    DOI： 10.1161/HYPERTENSIONAHA.113.02741 　

    ISSN： 0194-911X

    eISSN： 1524-4563

  396. Pleiotropic Effect of Common Variants at ABO Glycosyltranferase Locus in 9q32 on Plasma Levels of Pancreatic Lipase and Angiotensin Converting Enzyme Peer-reviewed

    Takamasa Kayama, Hidetoshi Yamashita, Akira Fukao, Isao Kubota, Takeo Kato, Chifumi Kitanaka, Shinya Sato, Yoshiyuki Ueno, Isao Kubota, Shinya Sato, Tsuneo Konta, Yoko Shibata, Tetsu Watanabe, Shuichi Abe, Takuya Miyamoto, Sumito Inoue, Takehiko Miyashita, Kazunobu Ichikawa, Tetsuro Shishido, Takanori Arimoto, Hiroki Takahashi, Satoshi Nishiyama, Ami Ikeda, Takeo Kato, Makoto Daimon, Toru Kawanami, Manabu Wada, Shigeki Arawaka, Hidetoshi Oizumi, Katsuro Kuro-Kawa, Shingi Susa, Yuichi Katou, Wataru Kameda, Shingo Koyama, Shigeru Karasawa, Chifumi Iseki, Yoshimi Takahashi, Chifumi Kitanaka, Yoshiyuki Ueno, Yoshiyuki Ueno, Sumio Kawata, Takafumi Saito, Naohiko Makino, Kazuo Okumoto, Hiroaki Haga, Takeshi Sato, Chikako Sato, Hisayoshi Watanabe, Yuko Nishise, Rika Ishii, Akiko Matsuda, Tomohiro Tozawa, Hidetoshi Yamashita, Kei Honma, Akira Fukao, Hiroto Narimatsu, Kyoko Shibata, Akiko Miura, Rina Inoue, Ai Numazawa, Kahori Kudo, Yoko Aita, Noriko Umezawa, Yuko Saito, Yumi Takahashi, Yuka Suzuki, Katsumi Otani, Atsushi Hozawa, Li Shao, Masatsugu Orui, Atsuko Kobayashi, Yuka Kanoya, Takiko Hosoya, Ikuko Suzuki, Mariko Otake, Yuko Morikagi, Akiko Sekimata, Manami Hiraka, Yumi Matsuda, Chika Sato, Yoko Takeda, Yoko Matsunami, Tatsuya Horie, Shiho Sato, Mizue Inoue, Kaoru Baba, Gen Tamiya, Masao Ueki, Tomohiro Nakamura, Gen Tamiya, Jamiyansuren Jambaldorj, Satoko Araki, Osamu Nakajima, Kazuei Takahashi, Kazuo Goto, Kimishige Ishizaka

    PLOS ONE　9　(2)　2014/02

    DOI： 10.1371/journal.pone.0055903 　

    ISSN： 1932-6203

  397. Long-chain n-3 polyunsaturated fatty acids intake and cardiovascular disease mortality risk in Japanese: A 24-year follow-up of NIPPON DATA80 Peer-reviewed

    Naoko Miyagawa, Katsuyuki Miura, Nagako Okuda, Takashi Kadowaki, Naoyuki Takashima, Shin-ya Nagasawa, Yasuyuki Nakamura, Yasuhiro Matsumura, Atsushi Hozawa, Akira Fujiyoshi, Takashi Hisamatsu, Katsushi Yoshita, Akira Sekikawa, Takayoshi Ohkubo, Robert D. Abbott, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima

    ATHEROSCLEROSIS　232　(2)　384-389　2014/02

    DOI： 10.1016/j.atherosclerosis.2013.11.073 　

    ISSN： 0021-9150

    eISSN： 1879-1484

  398. High long-chain n-3 fatty acid intake attenuates the effect of high resting heart rate on cardiovascular mortality risk: A 24-year follow-up of Japanese general population Peer-reviewed

    Takashi Hisamatsu, The NIPPON DATA 80 Research Group, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Yamamoto, Akira Fujiyoshi, Naoko Miyagawa, Aya Kadota, Naoyuki Takashima, Nagako Okuda, Katsushi Yoshita, Yoshikuni Kita, Yoshitaka Murakami, Yasuyuki Nakamura, Tomonori Okamura, Minoru Horie, Akira Okayama, Hirotsugu Ueshima

    Journal of Cardiology　64　(3)　218-224　2014

    Publisher: Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai)

    DOI： 10.1016/j.jjcc.2014.01.005 　

    ISSN： 1876-4738 0914-5087

  399. Risk Stratification by Self-Measured Home Blood Pressure across Categories of Conventional Blood Pressure: A Participant-Level Meta-Analysis Peer-reviewed

    Kei Asayama, Lutgarde Thijs, Jana Brguljan-Hitij, Teemu J. Niiranen, Atsushi Hozawa, Jose Boggia, Lucas S. Aparicio, Azusa Hara, Jouni K. Johansson, Takayoshi Ohkubo, Christophe Tzourio, George S. Stergiou, Edgardo Sandoya, Ichiro Tsuji, Antti M. Jula, Yutaka Imai, Jan A. Staessen

    PLOS MEDICINE　11　(1)　2014/01

    DOI： 10.1371/journal.pmed.1001591 　

    ISSN： 1549-1676

  400. Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: The metabotropic pathway Peer-reviewed

    Saulo J. A. Felizola, Yasuhiro Nakamura, Fumitoshi Satoh, Ryo Morimoto, Kumi Kikuchi, Tomohiro Nakamura, Atsushi Hozawa, Lin Wang, Yoshiaki Onodera, Kazue Ise, Keely M. McNamara, Sanae Midorikawa, Shinichi Suzuki, Hironobu Sasano

    MOLECULAR AND CELLULAR ENDOCRINOLOGY　382　(1)　170-177　2014/01

    DOI： 10.1016/j.mce.2013.09.025 　

    ISSN： 0303-7207

  401. Risk Stratification by Self-Measured Home Blood Pressure across Categories of Conventional Blood Pressure: A Participant-Level Meta-Analysis Peer-reviewed

    Kei Asayama, Lutgarde Thijs, Jana Brguljan-Hitij, Teemu J. Niiranen, Atsushi Hozawa, José Boggia, Lucas S. Aparicio, Azusa Hara, Jouni K. Johansson, Takayoshi Ohkubo, Christophe Tzourio, George S. Stergiou, Edgardo Sandoya, Ichiro Tsuji, Antti M. Jula, Yutaka Imai, Jan A. Staessen, K. Asayama, T. Ohkubo, M. Kikuya, R. Inoue, M. Satoh, M. Hosaka, M. T. Utsugi, T. Hirose, A. Hara, N. Fukushima, T. Obara, H. Metoki, Y. Imai, J. Johansson, A. Reunanen, A. Jula, K. Ohmori-Matsuda, S. Kuriyama, M. Kakizaki, A. Hozawa, I. Tsuji, T. Mountokalakis, A. Kollias, G. Thomopoulou, P. Kalogeropoulos, I. Skeva, E. Nasothimiou, N. Pantazis, N. Baibas, J. Boggia, E. Sandoya, J. A. Staessen, L. Thijs, N. Cauwenberghs, Z. Zhang, F. Wei, J. Knez, A. Odili, Y. Gu, Y. Liu, Y. Jin, L. Jacobs, T. Kuznetzova

    PLoS Medicine　11　(1)　e1001591　2014/01/01

    DOI： 10.1371/journal.pmed.1001591 　

    ISSN： 1549-1676 1549-1277

  402. Blood Pressure Among Public Employees After the Great East Japan Earthquake: The Watari Study Peer-reviewed

    Satoshi Konno, Atsushi Hozawa, Masanori Munakata

    AMERICAN JOURNAL OF HYPERTENSION　26　(9)　1059-1063　2013/09

    DOI： 10.1093/ajh/hpt065 　

    ISSN： 0895-7061

  403. Serum tatal cholesterol levels and eligibility for long-term care insurance A prospective cohort study of the Tsurugaya Project Peer-reviewed

    HOSHI Rena, TOMATA Yasutake, KAKIZAKI Masako, TSUBOYA Toru, NAGAI Masato, WATANABE Ikue, HOZAWA Atsushi, TSUJI Ichiro

    Nihon Koshu Eisei Zasshi(JAPANESE JOURNAL OF PUBLIC HEALTH)　60　(8)　435-443　2013/08/15

    Publisher: Japanese Society of Public Health

    DOI： 10.11236/jph.60.8_435 　

    ISSN： 0546-1766

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    Objectives&emsp;The purpose of this study was to examine the relationship between serum total cholesterol levels and certification eligibility for long-term care insurance in elderly Japanese individuals.<br/>Methods&emsp;The Tsurugaya Project was a comprehensive geriatric assessment conducted for community-dwelling elderly individuals aged &ge;70 years in the Tsurugaya area, Sendai, Japan. Of the 2,925 inhabitants, 958 subjects participated in the Tsurugaya Project. For this analysis, we used 827 subjects who gave informed consent and were not qualified for long-term care insurance at the time of the baseline survey. Subjects were followed up for 6 years. We classified the subjects into 4 quintiles and used the fourth quintile (212&ndash;230 mg/dL) as a reference for statistical analysis. We used Cox proportional hazards model to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of certification eligibility for long-term care insurance according to total cholesterol levels in serum.<br/>Results&emsp;During 6 years of follow-up, a total of 214 subjects were qualified for long-term care insurance certification. The lowest serum total cholesterol level (<177 mg/dL) was significantly associated with increased eligibility for long-term care insurance certification. Compared with the fourth quintile, multivariate HRs (95%CIs) of long-term care insurance certification were 1.91 (1.23&ndash;2.98), 1.36 (0.85&ndash;2.18), 0.99 (0.62&ndash;1.56), 1.38 (0.88&ndash;2.17), for <177 mg/dL, 177&ndash;194 mg/dL, 195&ndash;211 mg/dL, and &le;231 mg/dL, respectively. Moreover, the association was statistically significant even after excluding subjects with a history of liver disease or cancer, an abnormality in the liver function test, or high levels of high-sensitivity C-reactive protein.<br/>Conclusion&emsp;Low serum total cholesterol levels were significantly associated with increased eligibility for long-term care insurance certification even after adjusting for a variety of confounding factors.

  404. Interaction between dietary marine-derived n-3 fatty acids intake and J-point elevation on the risk of cardiac death: a 24-year follow-up of Japanese men Peer-reviewed

    Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Yamamoto, Akira Fujiyoshi, Naoko Miyagawa, Aya Kadota, Naoyuki Takashima, Nagako Okuda, Yasuhiro Matsumura, Katsushi Yoshita, Yoshikuni Kita, Yoshitaka Murakami, Yasuyuki Nakamura, Tomonori Okamura, Minoru Horie, Akira Okayama, Hirotsugu Ueshima

    HEART　99　(14)　1024-1029　2013/07

    DOI： 10.1136/heartjnl-2012-303496 　

    ISSN： 1355-6037

  405. OPTIMAL NUMBER OF HOME BLOOD PRESSURE MEASUREMENTS IN RELATION TO CARDIOVASCULAR OUTCOME Peer-reviewed

    Teemu J. Niiranen, Kei Asayama, Lutgarde Thijs, Jouni Johansson, Takayoshi Ohkubo, Masahiro Kikuya, Atsushi Hozawa, George S. Stergiou, Ichiro Tsuji, Antti Jula, Yutaka Imai, Jan A. Staessen

    JOURNAL OF CLINICAL HYPERTENSION　15　(7)　516-516　2013/07

    ISSN： 1524-6175

  406. Investigation of the correlation among diameter of retinal vessel and arteriosclerosis risk factors including hypoadiponectinemia Peer-reviewed

    Homma Kei, Kawasaki Ryo, Tanabe Yusuke, Saito Koko, Sugano Akira, Hozawa Atsushi, Takeo Katou, Kubota Isao, Kayama Takamasa, Yamashita Hidetoshi

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　54　(15)　2013/06

    ISSN： 0146-0404

  407. Family history of diabetes, lifestyle factors, and the 7-year incident risk of type 2 diabetes mellitus in middle-aged Japanese men and women.

    Masaru Sakurai, Koshi Nakamura, Katsuyuki Miura, Toshinari Takamura, Katsushi Yoshita, Satoshi Sasaki, Shin-Ya Nagasawa, Yuko Morikawa, Masao Ishizaki, Teruhiko Kido, Yuchi Naruse, Yasushi Suwazono, Hideaki Nakagawa

    Journal of diabetes investigation　4　(3)　261-8　2013/05/06

    DOI： 10.1111/jdi.12033 　

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    AIMS/INTRODUCTION: This cohort study of middle-aged Japanese participants investigated the relationship between family history of diabetes, the incident risk of type 2 diabetes and the interaction of these variables with other factors. MATERIALS AND METHODS: Study participants were 3,517 employees (2,037 men and 1,480 women) of a metal products factory in Japan. Baseline health examinations included questions about medical history, physical examination, anthropometric measurements, questions about lifestyle factors, such as smoking, alcohol consumption and habitual exercise, and a self-administered diet history questionnaire. Family history of diabetes was defined as having at least one-first-degree relative with diabetes. The incidence of diabetes was determined in annual medical examinations over a 7-year period. Hazard ratios (HRs) for type 2 diabetes were estimated by Cox proportional hazards analysis. RESULTS: Of the 3,517 participants, 630 (18%) had a family history of diabetes mellitus. During the study, 228 participants developed diabetes. The age and sex-adjusted HR for type 2 diabetes in participants with a family history of diabetes was 1.82 (95% confidence interval 1.36-2.43) as compared with those without a family history of diabetes. HRs did not change after adjustment for body mass index and lifestyle factors. We found no interactions with body mass index, insulin resistance, pancreatic β-cell function or lifestyle factors. CONCLUSIONS: Family history of diabetes was associated with the incident risk of diabetes, and these associations were independent of other risk factors, such as obesity, insulin resistance, and lifestyle factors in Japanese men and women.

  408. The confounding effect of cryptic relatedness for environmental risks of systolic blood pressure on cohort studies. International-journal Peer-reviewed

    Shibata K, Hozawa A, Tamiya G, Ueki M, Nakamura T, Narimatsu H, Kubota I, Ueno Y, Kato T, Yamashita H, Fukao A, Kayama T, Yamagata University, Genomic Cohort, Consortiuma

    Molecular genetics & genomic medicine　1　(1)　45-53　2013/05

    DOI： 10.1002/mgg3.4 　

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    The impact of cryptic relatedness (CR) on genomic association studies is well studied and known to inflate false-positive rates as reported by several groups. In contrast, conventional epidemiological studies for environmental risks, the confounding effect of CR is still uninvestigated. In this study, we investigated the confounding effect of unadjusted CR among a rural cohort in the relationship between environmental risk factors (body mass index, smoking status, alcohol consumption) and systolic blood pressure. We applied the methods of population-based whole-genome association studies for the analysis of the genome-wide single nucleotide polymorphism data in 1622 subjects, and detected 20.2% CR in this cohort population. In the case of the sample size, approximately 1000, the ratio of CR to the population was 20.2%, the population prevalence 25%, the prevalence in the CR 26%, heritability for liability 14.3% and prevalence in the subpopulation without CR 26%, the difference of estimated regression coefficient between samples with and without CR was not significant (P-value = 0.55). On the other hand, in another case with approximately >20% heritability for liability, we showed that confounding due to CR biased the estimation of exposure effects.

  409. Long sleep duration and cause-specific mortality according to physical function and self-rated health: the Ohsaki Cohort Study Peer-reviewed

    Masako Kakizaki, Shinichi Kuriyama, Naoki Nakaya, Toshimasa Sone, Masato Nagai, Yumi Sugawara, Atsushi Hozawa, Shin Fukudo, Ichiro Tsuji

    JOURNAL OF SLEEP RESEARCH　22　(2)　209-216　2013/04

    DOI： 10.1111/j.1365-2869.2012.01053.x 　

    ISSN： 0962-1105

  410. Relationship Between Serum Isoflavone Levels and Disability-Free Survival Among Community-Dwelling Elderly Individuals: Nested Case-Control Study of the Tsurugaya Project Peer-reviewed

    Atsushi Hozawa, Yumi Sugawara, Yasutake Tomata, Masako Kakizaki, Toru Tsuboya, Kaori Ohmori-Matsuda, Naoki Nakaya, Shinichi Kuriyama, Akira Fukao, Ichiro Tsuji

    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES　68　(4)　465-472　2013/04

    DOI： 10.1093/gerona/gls198 　

    ISSN： 1079-5006

  411. High-normal diastolic blood pressure is a risk for development of microalbuminuria in the general population: the Watari study Peer-reviewed

    Satoshi Konno, Atsushi Hozawa, Yukio Miura, Sadayoshi Ito, Masanori Munakata

    JOURNAL OF HYPERTENSION　31　(4)　798-804　2013/04

    DOI： 10.1097/HJH.0b013e32835e2146 　

    ISSN： 0263-6352

    eISSN： 1473-5598

  412. Long-chain n-3 Polyunsaturated Fatty Acids Intake and Cardiovascular Disease Mortality Risk in a General Japanese Population: NIPPON DATA80 Peer-reviewed

    Naoko Miyagawa, Katsuyuki Miura, Nagako Okuda, Takashi Kadowaki, Naoyuki Takashima, Shin-ya Nagasawa, Yasuyuki Nakamura, Yasuhiro Matsumura, Atsushi Hozawa, Akira Fujiyoshi, Takashi Hisamatsu, Katsushi Yoshita, Takayoshi Ohkubo, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima

    STROKE　44　(2)　2013/02

    ISSN： 0039-2499

    eISSN： 1524-4628

  413. A tomato-rich diet is related to depressive symptoms among an elderly population aged 70 years and over: A population-based, cross-sectional analysis Peer-reviewed

    Kaijun Niu, Hui Guo, Masako Kakizaki, Yufei Cui, Kaori Ohmori-Matsuda, Lei Guan, Atsushi Hozawa, Shinichi Kuriyama, Toru Tsuboya, Takashi Ohrui, Katsutoshi Furukawa, Hiroyuki Arai, Ichiro Tsuji, Ryoichi Nagatomi

    JOURNAL OF AFFECTIVE DISORDERS　144　(1-2)　165-170　2013/01

    DOI： 10.1016/j.jad.2012.04.040 　

    ISSN： 0165-0327

  414. Outcome-Driven Thresholds for Home Blood Pressure Measurement International Database of HOme blood pressure in relation to Cardiovascular Outcome Peer-reviewed

    Teemu J. Niiranen, Kei Asayama, Lutgarde Thijs, Jouni K. Johansson, Takayoshi Ohkubo, Masahiro Kikuya, Jose Boggia, Atsushi Hozawa, Edgardo Sandoya, George S. Stergiou, Ichiro Tsuji, Antti M. Jula, Yutaka Imai, Jan A. Staessen

    HYPERTENSION　61　(1)　27-+　2013/01

    DOI： 10.1161/HYPERTENSIONAHA.111.00100 　

    ISSN： 0194-911X

    eISSN： 1524-4563

  415. Consumption of dairy products and death from cardiovascular disease in the Japanese general population: the NIPPON DATA80. Peer-reviewed

    Imako Kondo, Toshiyuki Ojima, Mieko Nakamura, Shinya Hayasaka, Atsushi Hozawa, Shigeyuki Saitoh, Hirofumi Ohnishi, Hiroshi Akasaka, Takehito Hayakawa, Yoshitaka Murakami, Nagako Okuda, Katsuyuki Miura, Akira Okayama, Hirotsugu Ueshima

    Journal of epidemiology　23　(1)　47-54　2013

    DOI： 10.2188/jea.JE20120054 　

    ISSN： 0917-5040

    eISSN： 1349-9092

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    BACKGROUND: Recent Western studies show an inverse association between milk and dairy product intake and cardiovascular disease (CVD). We studied the association between consumption of milk and dairy products and CVD death in Japan. METHODS: Men and women aged 30 years or older were followed for 24 years. All had participated in a national nutrition survey in 300 health districts throughout Japan in 1980. The Cox proportional hazards model was used to assess mortality risk according to tertiles of milk and dairy product intake, with the high consumption group as reference. Hazard ratios (HRs) per 100-g/day increase in consumption were also estimated. RESULTS: During the 24-year follow-up period, there were 893 CVD deaths, 174 deaths from coronary heart disease (CHD), and 417 stroke deaths among 9243 participants. For women, the HRs for death from CVD, CHD, and stroke in the low consumption group were 1.27 (95% CI: 0.99-1.58; P for trend = 0.045), 1.67 (0.99-2.80; P = 0.02), and 1.34 (0.94-1.90; P = 0.08), respectively, after adjustment for age, body mass index, smoking status, alcohol drinking habits, history of diabetes, use of antihypertensives, work category, and total energy intake. With each 100-g/day increase in consumption of milk and dairy products, HRs tended to decrease for deaths from CVD (HR, 0.86; 95% CI, 0.74-0.99), CHD (0.73; 0.52-1.03), and stroke (0.81; 0.65-1.01) in women. No significant association was observed in men. CONCLUSIONS: Consumption of milk and dairy products was inversely associated with CVD death among women in Japan.

  416. Public awareness of early symptoms of stroke and information sources about stroke among the general Japanese population: the Acquisition of Stroke Knowledge Study. International-journal Peer-reviewed

    Naomi Miyamatsu, Tomonori Okamura, Hirofumi Nakayama, Kazunori Toyoda, Kazuo Suzuki, Akihiro Toyota, Takashi Hata, Atsushi Hozawa, Tomofumi Nishikawa, Akiko Morimoto, Mihoko Ogita, Ayumi Morino, Takenori Yamaguchi

    Cerebrovascular diseases (Basel, Switzerland)　35　(3)　241-9　2013

    DOI： 10.1159/000347066 　

    ISSN： 1015-9770

  417. Cancer patients on Twitter: a novel patient community on social media. International-journal Peer-reviewed

    Sugawara Y, Narimatsu H, Hozawa A, Shao L, Otani K, Fukao A

    BMC research notes　5　699-699　2012/12

    DOI： 10.1186/1756-0500-5-699 　

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    BACKGROUND: Patients increasingly turn to the Internet for information on medical conditions, including clinical news and treatment options. In recent years, an online patient community has arisen alongside the rapidly expanding world of social media, or "Web 2.0." Twitter provides real-time dissemination of news, information, personal accounts and other details via a highly interactive form of social media, and has become an important online tool for patients. This medium is now considered to play an important role in the modern social community of online, "wired" cancer patients. RESULTS: Fifty-one highly influential "power accounts" belonging to cancer patients were extracted from a dataset of 731 Twitter accounts with cancer terminology in their profiles. In accordance with previously established methodology, "power accounts" were defined as those Twitter accounts with 500 or more followers. We extracted data on the cancer patient (female) with the most followers to study the specific relationships that existed between the user and her followers, and found that the majority of the examined tweets focused on greetings, treatment discussions, and other instances of psychological support. These findings went against our hypothesis that cancer patients' tweets would be centered on the dissemination of medical information and similar "newsy" details. CONCLUSIONS: At present, there exists a rapidly evolving network of cancer patients engaged in information exchange via Twitter. This network is valuable in the sharing of psychological support among the cancer community.

  418. The International Database of HOme blood pressure in relation to Cardiovascular Outcome (IDHOCO): moving from baseline characteristics to research perspectives Peer-reviewed

    Teemu J. Niiranen, Lutgarde Thijs, Kei Asayama, Jouni K. Johansson, Takayoshi Ohkubo, Masahiro Kikuya, Jose Boggia, Atsushi Hozawa, Edgardo Sandoya, George S. Stergiou, Ichiro Tsuji, Antti M. Jula, Yutaka Imai, Jan A. Staessen

    HYPERTENSION RESEARCH　35　(11)　1072-1079　2012/11

    DOI： 10.1038/hr.2012.97 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  419. A Metabolomic Approach to Clarifying the Effect of AST-120 on 5/6 Nephrectomized Rats by Capillary Electrophoresis with Mass Spectrometry (CE-MS) Peer-reviewed

    Yasutoshi Akiyama, Yoichi Takeuchi, Koichi Kikuchi, Eikan Mishima, Yasuaki Yamamoto, Chitose Suzuki, Takafumi Toyohara, Takehiro Suzuki, Atsushi Hozawa, Sadayoshi Ito, Tomoyoshi Soga, Takaaki Abe

    TOXINS　4　(11)　1309-1322　2012/11

    DOI： 10.3390/toxins4111309 　

    ISSN： 2072-6651

  420. The predictive power of physical function assessed by questionnaire and physical performance measures for subsequent disability Peer-reviewed

    Masayuki Hoshi, Atsushi Hozawa, Shinichi Kuriyama, Naoki Nakaya, Kaori Ohmori-Matsuda, Toshimasa Sone, Masako Kakizaki, Kaijun Niu, Kazuki Fujita, Shouzoh Ueki, Hiroshi Haga, Ryoichi Nagatomi, Ichiro Tsuji

    Aging Clinical and Experimental Research　24　(4)　345-353　2012/08

    DOI： 10.3275/8104 　

    ISSN： 1594-0667 1720-8319

    eISSN： 1720-8319

  421. Relationship Between Serum Adiponectin Levels and Disability-Free Survival Among Community-Dwelling Elderly Individuals: The Tsurugaya Project Peer-reviewed

    Atsushi Hozawa, Yumi Sugawara, Yasutake Tomata, Masako Kakizaki, Toru Tsuboya, Kaori Ohmori-Matsuda, Naoki Nakaya, Shinichi Kuriyama, Akira Fukao, Ichiro Tsuji

    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES　67　(5)　530-536　2012/05

    DOI： 10.1093/gerona/glr191 　

    ISSN： 1079-5006

  422. C-reactive protein (CRP) is a predictor of high medical-care expenditures in a community-based elderly population aged 70 years and over: The Tsurugaya project Peer-reviewed

    Kaijun Niu, Atsushi Hozawa, Hui Guo, Kaori Ohmori-Matsuda, Yufei Cui, Satoru Ebihara, Naoki Nakaya, Shinichi Kuriyama, Toru Tsuboya, Masako Kakizaki, Takashi Ohrui, Hiroyuki Arai, Ichiro Tsuji, Ryoichi Nagatomi

    ARCHIVES OF GERONTOLOGY AND GERIATRICS　54　(3)　E392-E397　2012/05

    DOI： 10.1016/j.archger.2012.01.014 　

    ISSN： 0167-4943

  423. Green tea consumption and the risk of incident functional disability in elderly Japanese: the Ohsaki Cohort 2006 Study Peer-reviewed

    Yasutake Tomata, Masako Kakizaki, Naoki Nakaya, Toru Tsuboya, Toshimasa Sone, Shinichi Kuriyama, Atsushi Hozawa, Ichiro Tsuji

    AMERICAN JOURNAL OF CLINICAL NUTRITION　95　(3)　732-739　2012/03

    DOI： 10.3945/ajcn.111.023200 　

    ISSN： 0002-9165

  424. Gamma-Glutamyltransferase and Cancer Incidence: The Ohsaki Cohort Study Peer-reviewed

    Toru Tsuboya, Shinichi Kuriyama, Masato Nagai, Atsushi Hozawa, Yumi Sugawara, Yasutake Tomata, Masako Kakizaki, Yoshikazu Nishino, Ichiro Tsuji

    JOURNAL OF EPIDEMIOLOGY　22　(2)　144-150　2012/03

    DOI： 10.2188/jea.JE20110071 　

    ISSN： 0917-5040

  425. Relationship between dietary intake and microalbuminuria: findings from the Takahata study Peer-reviewed

    Masahiro Sato, Atsushi Hozawa, Tsuneo Konta, Li Shao, Katsumi Otani, Hiroto Narimatsu, Satoshi Sasaki, Takeo Kato, Isao Kubota, Hidetoshi Yamashita, Takamasa Kayama, Akira Fukao

    CLINICAL AND EXPERIMENTAL NEPHROLOGY　16　(1)　147-155　2012/02

    DOI： 10.1007/s10157-011-0539-5 　

    ISSN： 1342-1751

    eISSN： 1437-7799

  426. [Perceived stress and cardiovascular disease mortality. The Ohsaki Cohort Study]. Peer-reviewed

    Emi Kowata, Atsushi Hozawa, Masako Kakizaki, Yasutake Tomata, Masato Nagai, Yumi Sugawara, Shinichi Kuriyama, Ichiro Tsuji

    [Nihon koshu eisei zasshi] Japanese journal of public health　59　(2)　82-91　2012/02

    DOI： 10.11236/jph.59.2_82 　

    ISSN： 0546-1766

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    OBJECTIVES: Previous studies have indicated that stress can affect the circulatory system. Although prospective studies have examined the association between perceived stress and cardiovascular disease (CVD) mortality, the results are still controversial. The purpose of the present study was to elucidate the relationship with stratified analyses by alcohol intake category and smoking status. METHODS: The prospective Ohsaki Cohort Study covered all National Health Insurance beneficiaries aged 40 to 79 years living in the precinct of Ohsaki Public Health Center, Miyagi, Japan. A total of 45,293 Japanese (21,552 men and 23,741 women), without a history of cancer, ischemic heart disease or stroke, and who answered all items related to stress level at the baseline in 1994, were followed prospectively. Over 12 years of follow-up, 1,751 deaths from CVD occurred (994 men and 757 women). We used Cox proportional hazards models to calculate the hazard ratios (HR) and 95% confidence intervals (CI) for CVD mortality according to the perceived stress categories. The low stress category was used as the reference in all analyses. RESULTS: Perceived stress demonstrated a significant positive association with CVD mortality for men; the multivariate adjusted HR for high versus low stress was 1.43 (95% CI: 1.19, 1.87, P = 0.006). No significant relationship was noted for women. With current smokers, perceived high stress versus low had a pronounced association for both men (HR = 1.76, 95% CI: 1.28, 2.41, P = 0.001) and women (HR = 1.61, 95% CI: 1.20, 2.16, P = 0.004), and a similar tendency was noted for current drinking (HR = 1.56, 95% CI: 1.16, 2.09, P = 0.006, HR = 1.42, 95% CI: 1.08, 1.87, P = 0.001). Additionally, for both smoking and drinking men, those reporting high stress had 2 times the risk of CVD mortality of their low stress counterparts (P for trend < 0.001). The interaction of perceived stress with smoking for CVD mortality was of borderline statistical significance only for men (P for interaction = 0.04). CONCLUSION: The results suggest that the percentage of current smoking and drinking are factors that distinguish between sexes with regard to the effects of perceived stress on the incidence of CVD mortality. Furthermore our present findings indicate that smoking and drinking habit are not the way to relieve one's stress. A review of these should be conducted and we need to enhance support for stress management as well as control over smoking and drinking habits.

  427. Serum Glycerophosphate Levels are Increased in Japanese Men with Type 2 Diabetes Peer-reviewed

    Makoto Daimon, Tomoyoshi Soga, Atsushi Hozawa, Toshihide Oizumi, Wataru Kaino, Kaoru Takase, Shigeru Karasawa, Yumi Jimbu, Kiriko Wada, Wataru Kameda, Shinji Susa, Takamasa Kayama, Kaori Saito, Masaru Tomita, Takeo Kato

    INTERNAL MEDICINE　51　(6)　545-551　2012

    DOI： 10.2169/internalmedicine.51.6612 　

    ISSN： 0918-2918

  428. Impact of obesity, overweight and underweight on life expectancy and lifetime medical expenditures: the Ohsaki Cohort Study Peer-reviewed

    Masato Nagai, Shinichi Kuriyama, Masako Kakizaki, Kaori Ohmori-Matsuda, Toshimasa Sone, Atsushi Hozawa, Miyuki Kawado, Shuji Hashimoto, Ichiro Tsuji

    BMJ OPEN　2　(3)　2012

    DOI： 10.1136/bmjopen-2012-000940 　

    ISSN： 2044-6055

  429. Impact of blunted perception of dyspnea on medical care use and expenditure, and mortality in elderly people Peer-reviewed

    Satoru Ebihara, Kaijun Niu, Takae Ebihara, Shinichi Kuriyama, Atsushi Hozawa, Kaori Ohmori-Matsuda, Naoki Nakaya, Ryoichi Nagatomi, Hiroyuki Arai, Masahiro Kohzuki, Ichiro Tsuji

    FRONTIERS IN PHYSIOLOGY　3　238　2012

    DOI： 10.3389/fphys.2012.00238 　

    ISSN： 1664-042X

  430. Impact of physical activity and performance on medical care costs among the Japanese elderly Peer-reviewed

    Guang Yang, Kaijun Niu, Kazuki Fujita, Atsushi Hozawa, Kaori Ohmori-Matsuda, Shinichi Kuriyama, Naoki Nakaya, Satoru Ebihara, Tatsuma Okazaki, Hiu Guo, Chihaya Miura, Hideko Takahashi, Hiroyuki Arai, Ichiro Tsuji, Ryoichi Nagatomi

    GERIATRICS & GERONTOLOGY INTERNATIONAL　11　(2)　157-165　2011/04

    DOI： 10.1111/j.1447-0594.2010.00651.x 　

    ISSN： 1444-1586

  431. 2010年国民健康栄養調査対象者の追跡開始（NIPPON DATA 2010)とNIPPON DATA80/90の追跡継続に関する研究

    42012　2011/03

  432. 平成22年国民健康・栄養調査 実施自治体への協力依頼

    19-30　2011/03

  433. Relationship of moderate metabolic risk factor clustering to cardiovascular disease mortality in non-lean Japanese: A 15-year follow-up of NIPPON DATA90 Peer-reviewed

    Aya Kadota, Katsuyuki Miura, Tomonori Okamura, Atsushi Hozawa, Yoshitaka Murakami, Akira Fujiyoshi, Naoyuki Takashima, Takehito Hayakawa, Yoshikuni Kita, Akira Okayama, Yasuyuki Nakamura, Hirotsugu Ueshima

    ATHEROSCLEROSIS　215　(1)　209-213　2011/03

    DOI： 10.1016/j.atherosclerosis.2010.11.033 　

    ISSN： 0021-9150

  434. Risk factors for overactive bladder in the elderly population: A community-based study with face-to-face interview Peer-reviewed

    Yoshihiro Ikeda, Haruo Nakagawa, Kaori Ohmori-Matsuda, Atsushi Hozawa, Yayoi Masamune, Yoshikazu Nishino, Shinichi Kuriyama, Tetsutaro Ohnuma, Ichiro Tsuji, Yoichi Arai

    INTERNATIONAL JOURNAL OF UROLOGY　18　(3)　212-218　2011/03

    DOI： 10.1111/j.1442-2042.2010.02696.x 　

    ISSN： 0919-8172

  435. Attributable Fractions of Risk Factors for Cardiovascular Diseases Peer-reviewed

    Atsushi Hozawa

    JOURNAL OF EPIDEMIOLOGY　21　(2)　81-86　2011/03

    DOI： 10.2188/jea.JE20100081 　

    ISSN： 0917-5040

  436. History of cholelithiasis and the risk of prostate cancer: the Ohsaki Cohort Study Peer-reviewed

    Qiang Li, Shinichi Kuriyama, Masako Kakizaki, Hong Yan, Masato Nagai, Yumi Sugawara, Kaori Ohmori-Matsuda, Atsushi Hozawa, Yoshikazu Nishino, Ichiro Tsuji

    INTERNATIONAL JOURNAL OF CANCER　128　(1)　185-191　2011/01

    DOI： 10.1002/ijc.25303 　

    ISSN： 0020-7136

  437. Seasonal Variation in Home Blood Pressure Measurements and Relation to Outside Temperature in Japan Peer-reviewed

    Atsushi Hozawa, Shinichi Kuriyama, Taichi Shimazu, Kaori Ohmori-Matsuda, Ichiro Tsuji

    CLINICAL AND EXPERIMENTAL HYPERTENSION　33　(3)　153-158　2011

    DOI： 10.3109/10641963.2010.531841 　

    ISSN： 1064-1963

  438. [Validation of the Kihon Checklist for predicting the risk of 1-year incident long-term care insurance certification: the Ohsaki Cohort 2006 Study]. Peer-reviewed

    Yasutake Tomata, Atsushi Hozawa, Kaori Ohmori-Matsuda, Masato Nagai, Yumi Sugawara, Akemi Nitta, Shinichi Kuriyama, Ichiro Tsuji

    [Nihon koshu eisei zasshi] Japanese journal of public health　58　(1)　3-13　2011/01

    DOI： 10.11236/jph.58.1_3 　

    ISSN： 0546-1766

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    OBJECTIVE: The "Kihon Checklist" (a frailty checklist), consisting of 25 items, is used for screening frail elderly, based on the Japanese long-term care insurance system. However, few reports have investigated predictive ability of incident long-term care insurance certification in the Kihon Checklist. The purpose of this study was to investigate inter-relationships and accuracy as a screening test of individual items and criteria in the Kihon Checklist for incident long-term care insurance certification. METHODS: In December 2006, we distributed a questionnaire including the Kihon Checklist to individuals older than 65 years living in Ohsaki City, Japan. Among the valid respondents, we followed those who gave informed consent to follow-up, had more than 1 item of response on the Kihon Checklist, and were not qualified for long-term care insurance certification at the baseline. We further excluded individuals who died or moved away in the one year follow-up, analyzing 14,636 elderly. The age- and sex-adjusted odds ratio (OR) and 95% confidence interval (95%CI) for newly incident long-term care insurance certification were estimated by logistic regression analysis. Independent variables were each of the items and criteria in the Kihon Checklist used for screening of "frail elderly". In addition, we estimated the sensitivity and specificity, and conducted receiver operating characteristic (ROC) analysis for each criteria domain. RESULTS: 5,560 (38.0%) matched the criteria of "frail elderly". During the one year of follow-up, 483 (3.3%) required newly incident long-term care insurance certification. All of the items in the Kihon Checklist were significantly associated with incident long-term care insurance certification (range of ORs: 1.45-4.67). In addition, all of the criteria also significantly predicted the risk of incident long-term care insurance certification (range of OR: 1.93-6.54). The OR (95%CI) for "frail elderly" was 3.80 (3.02-4.78). Among the various domains, "20 items other than five related to prevention and support for depression" had the largest area under the ROC curve. CONCLUSION: All items and criteria used for screening frail elderly in the Kihon Checklist are useful for predicting the risk of incident long-term care insurance certification during a one-year period. However, the strength of the relation and accuracy for screening test were variable among items or domains, and criteria values could be improved.

  439. Impact of walking on life expectancy and lifetime medical expenditure: the Ohsaki Cohort Study Peer-reviewed

    Masato Nagai, Shinichi Kuriyama, Masako Kakizaki, Kaori Ohmori-Matsuda, Toshimasa Sone, Atsushi Hozawa, Miyuki Kawado, Shuji Hashimoto, Ichiro Tsuji

    BMJ OPEN　1　(2)　e000240　2011

    DOI： 10.1136/bmjopen-2011-000240 　

    ISSN： 2044-6055

  440. Randomized controlled trial for an effect of catechin-enriched green tea consumption on adiponectin and cardiovascular disease risk factors Peer-reviewed

    Toshimasa Sone, Shinichi Kuriyama, Naoki Nakaya, Atsushi Hozawa, Taichi Shimazu, Kozue Nomura, Shouzo Rikimaru, Ichiro Tsuji

    FOOD & NUTRITION RESEARCH　55　2011

    DOI： 10.3402/fnr.v55i0.8326 　

    ISSN： 1654-6628

    eISSN： 1654-661X

  441. RELATIONSHIPS BETWEEN N-TERMINAL PRO B-TYPE NATRIURETIC PEPTIDE AND INCIDENT DISABILITY AND MORTALITY IN OLDER COMMUNITY-DWELLING ADULTS: THE TSURUGAYA STUDY Peer-reviewed

    Atsushi Hozawa, Yumi Sugawara, Yasutake Tomata, Masako Kakizaki, Kaori Ohmori-Matsuda, Naoki Nakaya, Shinichi Kuriyama, Akira Fukao, Ichiro Tsuji

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY　58　(12)　2439-2441　2010/12

    DOI： 10.1111/j.1532-5415.2010.03190.x 　

    ISSN： 0002-8614

  442. Participation in health check-ups and mortality using propensity score matched cohort analyses Peer-reviewed

    Atsushi Hozawa, Shinichi Kuriyama, Ikue Watanabe, Masako Kakizaki, Kaori Ohmori-Matsuda, Toshimasa Sone, Masato Nagai, Yumi Sugawara, Akemi Nitta, Qiang Li, Takayoshi Ohkubo, Yoshitaka Murakami, Ichiro Tsuji

    PREVENTIVE MEDICINE　51　(5)　397-402　2010/11

    DOI： 10.1016/j.ypmed.2010.08.017 　

    ISSN： 0091-7435

  443. Citrus consumption and cancer incidence: the Ohsaki cohort study Peer-reviewed

    Wen-Qing Li, Shinichi Kuriyama, Qiang Li, Masato Nagai, Atsushi Hozawa, Yoshikazu Nishino, Ichiro Tsuji

    INTERNATIONAL JOURNAL OF CANCER　127　(8)　1913-1922　2010/10

    DOI： 10.1002/ijc.25203 　

    ISSN： 0020-7136

  444. Impact of Nocturia on Bone Fracture and Mortality in Older Individuals: A Japanese Longitudinal Cohort Study Peer-reviewed

    Haruo Nakagawa, Kaijun Niu, Atsushi Hozawa, Yoshihiro Ikeda, Yasuhiro Kaiho, Kaori Ohmori-Matsuda, Naoki Nakaya, Shinichi Kuriyama, Satoru Ebihara, Ryoichi Nagatomi, Ichiro Tsuji, Yoichi Arai

    JOURNAL OF UROLOGY　184　(4)　1413-1418　2010/10

    DOI： 10.1016/j.juro.2010.05.093 　

    ISSN： 0022-5347

  445. Mild metabolic abnormalities, abdominal obesity and the risk of cardiovascular diseases in middle-aged Japanese men.

    Wataru Hirokawa, Koshi Nakamura, Masaru Sakurai, Yuko Morikawa, Katsuyuki Miura, Masao Ishizaki, Katsushi Yoshita, Teruhiko Kido, Yuchi Naruse, Hideaki Nakagawa

    Journal of atherosclerosis and thrombosis　17　(9)　934-43　2010/09/30

    eISSN： 1880-3873

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    AIM: We investigated the individual and population impacts of mild abnormalities associated with metabolic syndrome (blood pressure, lipids and glucose) and abdominal obesity, for which lifestyle modification is initially applicable, on cardiovascular disease risk. METHODS: Using a cohort study of 2,685 Japanese men aged 35 to 59 years with an 11-year follow-up period, we calculated the relative risks for cardiovascular diseases due to mild metabolic abnormalities that included at least one of the following three conditions: 1) systolic blood pressure 130-139 mmHg and/or diastolic blood pressure 85-89 mmHg; 2) triglycerides 150-299 mg/dL and/or high-density lipoprotein cholesterol 35-39 mg/dL; and 3) fasting plasma glucose 110-125 mg/dL and/or abdominal obesity. Participants with a mild metabolic abnormality were compared to participants with no metabolic abnormality or abdominal obesity. The population attributable fraction of these abnormalities for cardiovascular diseases was also estimated. RESULTS: At baseline, 9.8% and 21.8% of the total population had a mild metabolic abnormality with or without abdominal obesity, respectively, while 7.5% had isolated abdominal obesity without any metabolic abnormality. A mild metabolic abnormality with or without abdominal obesity and isolated abdominal obesity increased the risk of cardiovascular disease by 2.68-fold, 1.49-fold, and 2.36-fold, respectively. Approximately 20% of cardiovascular diseases in the total population were attributable to either mild metabolic abnormalities or isolated abdominal obesity. CONCLUSION: The importance of lifestyle modification should be acknowledged, especially in cases of mild metabolic abnormality and/or abdominal obesity, which may contribute to approximately 20% of the population burden for cardiovascular diseases.

  446. Bundle branch block and other cardiovascular disease risk factors: US-Japan comparison Peer-reviewed

    Longjian Liu, Tomonori Okamura, Takashi Kadowaki, Yoshitaka Murakami, Atsushi Hozawa, Yoshikuni Kita, Naoyuki Takashima, Nagako Okuda, Akira Okayama, Hirotsugu Ueshima

    INTERNATIONAL JOURNAL OF CARDIOLOGY　143　(3)　432-440　2010/09

    DOI： 10.1016/j.ijcard.2008.12.022 　

    ISSN： 0167-5273

  447. Metabolomic profiling of uremic solutes in CKD patients Peer-reviewed

    Takafumi Toyohara, Yasutoshi Akiyama, Takehiro Suzuki, Yoichi Takeuchi, Eikan Mishima, Masayuki Tanemoto, Ayako Momose, Naoko Toki, Hiroshi Sato, Masaaki Nakayama, Atsushi Hozawa, Ichiro Tsuji, Sadayoshi Ito, Tomoyoshi Soga, Takaaki Abe

    HYPERTENSION RESEARCH　33　(9)　944-952　2010/09

    DOI： 10.1038/hr.2010.113 　

    ISSN： 0916-9636

  448. Cigarette smoking in middle age and a long-term risk of impaired activities of daily living: NIPPON DATA80 Peer-reviewed

    Naoyuki Takashima, Katsuyuki Miura, Atsushi Hozawa, Tomonori Okamura, Takehito Hayakawa, Nagako Okuda, Takashi Kadowaki, Yoshitaka Murakami, Yoshikuni Kita, Yasuyuki Nakamura, Akira Okayama, Hirotsugu Ueshima

    NICOTINE & TOBACCO RESEARCH　12　(9)　944-949　2010/09

    DOI： 10.1093/ntr/ntq121 　

    ISSN： 1462-2203

  449. Effect of Age on the Association between Body Mass Index and All-Cause Mortality: The Ohsaki Cohort Study Peer-reviewed

    Masato Nagai, Shinichi Kuriyama, Masako Kakizaki, Kaori Ohmori-Matsuda, Yumi Sugawara, Toshimasa Sone, Atsushi Hozawa, Ichiro Tsuji

    JOURNAL OF EPIDEMIOLOGY　20　(5)　398-407　2010/09

    DOI： 10.2188/jea.JE20090204 　

    ISSN： 0917-5040

  450. History of diabetes mellitus and the risk of prostate cancer: the Ohsaki Cohort Study Peer-reviewed

    Qiang Li, Shinichi Kuriyama, Masako Kakizaki, Hong Yan, Toshimasa Sone, Masato Nagai, Yumi Sugawara, Kaori Ohmori-Matsuda, Atsushi Hozawa, Yoshikazu Nishino, Ichiro Tsuji

    CANCER CAUSES & CONTROL　21　(7)　1025-1032　2010/07

    DOI： 10.1007/s10552-010-9530-9 　

    ISSN： 0957-5243

  451. [Depression and the risk of long-term care insurance certification: the Tsurugaya project]. Peer-reviewed

    Ohmori-Matsuda K, Hozawa A, Sone T, Koizumi-Masamune Y, Nakaya N, Kuriyama S, Suzuki S, Awata S, Tsuji I

    [Nihon koshu eisei zasshi] Japanese journal of public health　57　(7)　538-549　2010/07

    Publisher: Japanese Society of Public Health

    DOI： 10.11236/jph.57.7_538 　

    ISSN： 0546-1766

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    Objective The purpose of this study was to examine the relationship between depressive status and subsequent certification of long-term care insurance use, and to investigate sex differences in this relationship in an elderly Japanese population.<br/>Methods The Tsurugaya Project was a comprehensive geriatric assessment conducted for community-dwelling elderly persons aged 70 years or older in the Tsurugaya area, Sendai, Japan (N=2,925). Of those who participated (N=958), the 841 who gave informed consent and were not qualified for certification of long-term care insurance use at the baseline survey were analyzed. Depression was assessed using the 30-item Geriatric Depression Scale (GDS). We classified the subjects into three categories: normal (GDS less than 10), mild depression (GDS between 10 and 13), and moderate to severe depression (GDS more than 13 and/or taking antidepressive medication). The hazard ratio of incident certification of long-term care insurance use by depressive status was calculated using the Cox proportional hazards model.<br/>Results During 4 years of follow-up, a total of 151 subjects were certificated for long-term care insurance and 46 subjects died. Particularly in men, the depressive status was related to subsequent incident certification of long-term care insurance use. In men, the age-adjusted hazard ratios (HRs) were 1.77 (95% confidence interval (CI): 0.91-3.48) for mild depression, and 2.26 (1.11-4.64) for moderate to severe depression (P for trend=0.023). The relationship between depressive status and subsequent certification of long-term care insurance use in men was significant even after adjustment for age, comorbid conditions, social factors and lifestyle (multivariate-adjusted HR: 1.31 (95% CI: 0.65-2.65); mild depression 2.19 (1.06-4.54); moderate to severe depression: P for trend=0.034). In women, there was no significant association between depressive status and certification of long-term care insurance use. In both sexes, there was no significant association between depressive status and death.<br/>Conclusion The relationship between depressive status and subsequent certification of long-term care insurance use was significant only in men. In men, the relationship was significant even after adjustment for age, comorbid conditions, social factors and lifestyle. These results suggest a sex difference in the relationship between depressive status and subsequent certification of long-term care insurance use in elderly Japanese.

  452. 過活動膀胱(OAB)の基礎と臨床 過活動膀胱の疫学とリスクファクター Peer-reviewed

    中川晴夫, 池田義弘, 寶澤篤, 辻一郎, 荒井陽一

    日本平滑筋学会雑誌　14　(1)　J-10　2010/06

  453. Population Attributable Fraction of Smoking and Metabolic Syndrome on Cardiovascular Disease Mortality in Japan: a 15-Year Follow Up of NIPPON DATA90 Peer-reviewed

    Naoyuki Takashima, Katsuyuki Miura, Atsushi Hozawa, Aya Kadota, Tomonori Okamura, Yasuyuki Nakamura, Takehito Hayakawa, Nagako Okuda, Akira Fujiyoshi, Shin-ya Nagasawa, Takashi Kadowaki, Yoshitaka Murakami, Yoshikuni Kita, Akira Okayama, Hirotsugu Ueshima

    BMC PUBLIC HEALTH　10　306　2010/06

    DOI： 10.1186/1471-2458-10-306 　

    ISSN： 1471-2458

  454. Coffee Consumption and Mortality Due to All Causes, Cardiovascular Disease, and Cancer in Japanese Women Peer-reviewed

    Kemmyo Sugiyama, Shinichi Kuriyama, Munira Akhter, Masako Kakizaki, Naoki Nakaya, Kaori Ohmori-Matsuda, Taichi Shimazu, Masato Nagai, Yumi Sugawara, Atsushi Hozawa, Akira Fukao, Ichiro Tsuji

    JOURNAL OF NUTRITION　140　(5)　1007-1013　2010/05

    DOI： 10.3945/jn.109.109314 　

    ISSN： 0022-3166

  455. Coffee consumption and mortality due to all causes, cardiovascular disease, and cancer in Japanese women. International-journal Peer-reviewed

    Kemmyo Sugiyama, Shinichi Kuriyama, Munira Akhter, Masako Kakizaki, Naoki Nakaya, Kaori Ohmori-Matsuda, Taichi Shimazu, Masato Nagai, Yumi Sugawara, Atsushi Hozawa, Akira Fukao, Ichiro Tsuji

    The Journal of nutrition　140　(5)　1007-13　2010/05

    DOI： 10.3945/jn.109.109314 　

    ISSN： 0022-3166

  456. The Ohsaki Cohort 2006 Study: Design of Study and Profile of Participants at Baseline Peer-reviewed

    Shinichi Kuriyama, Naoki Nakaya, Kaori Ohmori-Matsuda, Taichi Shimazu, Nobutaka Kikuchi, Masako Kakizaki, Toshimasa Sone, Fumi Sato, Masato Nagai, Yumi Sugawara, Yasutake Tomata, Munira Akhter, Mizuka Higashiguchi, Naru Fukuchi, Hideko Takahashi, Atsushi Hozawa, Ichiro Tsuji

    JOURNAL OF EPIDEMIOLOGY　20　(3)　253-258　2010/05

    DOI： 10.2188/jea.JE20090093 　

    ISSN： 0917-5040

  457. Association between green tea consumption and tooth loss: Cross-sectional results from the Ohsaki Cohort 2006 Study Peer-reviewed

    Yasushi Koyama, Shinichi Kuriyama, Jun Aida, Toshimasa Sone, Naoki Nakaya, Kaori Ohmori-Matsuda, Atsushi Hozawa, Ichiro Tsuji

    PREVENTIVE MEDICINE　50　(4)　173-179　2010/04

    DOI： 10.1016/j.ypmed.2010.01.010 　

    ISSN： 0091-7435

  458. Passive Smoke Exposure and Circulating Carotenoids in the CARDIA Study Peer-reviewed

    Rachel Widome, David R. Jacobs, Atsushi Hozawa, Femke Sijtsma, Myron Gross, Pamela J. Schreiner, Carlos Iribarren

    ANNALS OF NUTRITION AND METABOLISM　56　(2)　113-118　2010/03

    DOI： 10.1159/000277662 　

    ISSN： 0250-6807

  459. Relation of Gamma-Glutamyltransferase and Alcohol Drinking with Incident Diabetes: the HIPOP-OHP Study Peer-reviewed

    Atsushi Hozawa, Tomonori Okamura, Taichiro Tanaka, Katsuyuki Miura, Yuriko Kikuchi, Takashi Kadowaki, Katsushi Yoshita, Toru Takebayashi, Junko Tamaki, Junko Minai, Takayo Tada, Nagako Chiba, Akira Okayama, Hirotsugu Ueshima

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS　17　(2)　195-202　2010

    DOI： 10.5551/jat.3202 　

    ISSN： 1340-3478

    eISSN： 1880-3873

  460. What Psychosocial Characteristics are Associated with Smoking Cessation Behavior and Readiness to Quit Smoking Among Japanese Male Ever-Smokers with Type 2 Diabetes Mellitus Peer-reviewed

    Akiko Morimoto, Naomi Miyamatsu, Tomonori Okamura, Atsushi Hozawa, Aya Kadota, Miho Morinaga, Mihoko Ogita, Atsunori Kashiwagi, Hirotsugu Ueshima

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS　17　(4)　361-368　2010

    DOI： 10.5551/jat.3194 　

    ISSN： 1340-3478

    eISSN： 1880-3873

  461. Relationship of the Polyunsaturated to Saturated Fatty Acid Ratio to Cardiovascular Risk Factors and Metabolic Syndrome in Japanese: the INTERLIPID Study Peer-reviewed

    Zhao Guo, Katsuyuki Miura, Tanvir Chowdhury Turin, Atsushi Hozawa, Nagako Okuda, Tomonori Okamura, Shigeyuki Saitoh, Kiyomi Sakata, Hideaki Nakagawa, Akira Okayama, Katsushi Yoshita, Takashi Kadowaki, Sohel R. Choudhury, Yasuyuki Nakamura, Beatriz L. Rodriguez, J. David Curb, Paul Elliott, Jeremiah Stamler, Hirotsugu Ueshima

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS　17　(8)　777-784　2010

    DOI： 10.5551/jat.4135 　

    ISSN： 1340-3478

    eISSN： 1880-3873

  462. Dietary patterns associated with fall-related fracture in elderly Japanese: a population based prospective study Peer-reviewed

    Yasutake Monma, Kaijun Niu, Koh Iwasaki, Naoki Tomita, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Shin Takayama, Takashi Seki, Takashi Takeda, Nobuo Yaegashi, Satoru Ebihara, Hiroyuki Arai, Ryoichi Nagatomi, Ichiro Tsuji

    BMC GERIATRICS　10　31　2010

    DOI： 10.1186/1471-2318-10-31 　

    ISSN： 1471-2318

  463. Relationship between Peripheral Arterial Disease and Incident Disability among Elderly Japanese: the Tsurugaya Project Peer-reviewed

    Akemi Nitta, Atsushi Hozawa, Shinichi Kuriyama, Naoki Nakaya, Kaori Ohmori-Matsuda, Toshimasa Sone, Masako Kakizaki, Satoru Ebihara, Masataka Ichiki, Hiroyuki Arai, Ichiro Tsuji

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS　17　(12)　1290-1296　2010

    DOI： 10.5551/jat.5389 　

    ISSN： 1340-3478

    eISSN： 1880-3873

  464. Green tea consumption and the risk of liver cancer in Japan: the Ohsaki Cohort study Peer-reviewed

    Akane Ui, Shinichi Kuriyama, Masako Kakizaki, Toshimasa Sone, Naoki Nakaya, Kaori Ohmori-Matsuda, Atsushi Hozawa, Yoshikazu Nishino, Ichiro Tsuji

    CANCER CAUSES & CONTROL　20　(10)　1939-1945　2009/12

    DOI： 10.1007/s10552-009-9388-x 　

    ISSN： 0957-5243

  465. Green tea consumption is associated with depressive symptoms in the elderly Peer-reviewed

    Kaijun Niu, Atsushi Hozawa, Shinichi Kuriyama, Satoru Ebihara, Hui Guo, Naoki Nakaya, Kaori Ohmori-Matsuda, Hideko Takahashi, Yayoi Masamune, Masanori Asada, Satoshi Sasaki, Hiroyuki Arai, Shuichi Awata, Ryoichi Nagatomi, Ichiro Tsuji

    AMERICAN JOURNAL OF CLINICAL NUTRITION　90　(6)　1615-1622　2009/12

    DOI： 10.3945/ajcn.2009.28216 　

    ISSN： 0002-9165

  466. Blood pressure differences by race: the importance of assessing lifestyle Peer-reviewed

    Atsushi Hozawa, Hirotsugu Ueshima

    HYPERTENSION RESEARCH　32　(12)　1049-1050　2009/12

    DOI： 10.1038/hr.2009.167 　

    ISSN： 0916-9636

  467. Alcohol intake and 19-year mortality in diabetic men: NIPPON DATA80 Peer-reviewed

    Yasuyuki Nakamura, Hirotsugu Ueshima, Aya Kadota, Atsushi Hozawa, Tomonori Okamura, Sayaka Kadowaki, Takashi Kadowaki, Takehito Hayakawa, Yoshikuni Kita, Robert D. Abbott, Akira Okayama

    ALCOHOL　43　(8)　635-641　2009/12

    DOI： 10.1016/j.alcohol.2009.06.005 　

    ISSN： 0741-8329

  468. Factors Associated With Psychological Distress in a Community-Dwelling Japanese Population: The Ohsaki Cohort 2006 Study Peer-reviewed

    Shinichi Kuriyama, Naoki Nakaya, Kaori Ohmori-Matsuda, Taichi Shimazu, Nobutaka Kikuchi, Masako Kakizaki, Toshimasa Sone, Fumi Sato, Masato Nagai, Yumi Sugawara, Munira Akhter, Mizuka Higashiguchi, Naru Fukuchi, Hideko Takahashi, Atsushi Hozawa, Ichiro Tsuji

    JOURNAL OF EPIDEMIOLOGY　19　(6)　294-302　2009/11

    DOI： 10.2188/jea.JE20080076 　

    ISSN： 0917-5040

  469. Green tea consumption is associated with lower psychological distress in a general population: the Ohsaki Cohort 2006 Study Peer-reviewed

    Atsushi Hozawa, Shinichi Kuriyama, Naoki Nakaya, Kaori Ohmori-Matsuda, Masako Kakizaki, Toshimasa Sone, Masato Nagai, Yumi Sugawara, Akemi Nitta, Yasutake Tomata, Kaijun Niu, Ichiro Tsuji

    AMERICAN JOURNAL OF CLINICAL NUTRITION　90　(5)　1390-1396　2009/11

    DOI： 10.3945/ajcn.2009.28214 　

    ISSN： 0002-9165

  470. Green tea and death from pneumonia in Japan: the Ohsaki cohort study Peer-reviewed

    Ikue Watanabe, Shinichi Kuriyama, Masako Kakizaki, Toshimasa Sone, Kaori Ohmori-Matsuda, Naoki Nakaya, Atsushi Hozawa, Ichiro Tsuji

    AMERICAN JOURNAL OF CLINICAL NUTRITION　90　(3)　672-679　2009/09

    DOI： 10.3945/ajcn.2009.27599 　

    ISSN： 0002-9165

    eISSN： 1938-3207

  471. Cortical areas related to performance of WAIS Digit Symbol Test: A functional imaging study Peer-reviewed

    Nobuo Usui, Tomoki Haji, Masakazu Maruyama, Narumi Katsuyama, Shinya Uchida, Atsushi Hozawa, Kahoru Omori, Ichiro Tsuji, Ryuta Kawashima, Masato Taira

    NEUROSCIENCE LETTERS　463　(1)　1-5　2009/09

    DOI： 10.1016/j.neulet.2009.07.048 　

    ISSN： 0304-3940

  472. Green Tea Consumption and Hematologic Malignancies in Japan Peer-reviewed

    Toru Naganuma, Shinichi Kuriyama, Masako Kakizaki, Toshimasa Sone, Naoki Nakaya, Kaori Ohmori-Matsuda, Atsushi Hozawa, Yoshikazu Nishino, Ichiro Tsuji

    AMERICAN JOURNAL OF EPIDEMIOLOGY　170　(6)　730-738　2009/09

    DOI： 10.1093/aje/kwp187 　

    ISSN： 0002-9262

  473. Cholesteryl Ester Transfer Protein, Coronary Calcium, and Intima-Media Thickness of the Carotid Artery in Middle-Age Japanese Men Peer-reviewed

    Tomonori Okamura, Akira Sekikawa, Takashi Kadowaki, Aiman El-Saed, Robert D. Abbott, J. David Curb, Daniel Edmundowicz, Yasuyuki Nakamura, Kiyoshi Murata, Atsunori Kashiwagi, Kim Sutton-Tyrrell, Rhobert W. Evans, Joseph M. Zmuda, Hiroshi Maegawa, Atsushi Hozawa, Ken-Ichi Mitsunami, Yoshihiko Nishio, Iva Miljkovic-Gacic, Minoru Horie, Naomi Miyamatsu, Yoshitaka Murakami, Lewis H. Kuller, Hirotsugu Ueshima

    AMERICAN JOURNAL OF CARDIOLOGY　104　(6)　818-822　2009/09

    DOI： 10.1016/j.amjcard.2009.05.021 　

    ISSN： 0002-9149

  474. Determinants of the Utilization of Dental Services in a Community-Dwelling Elderly Japanese Population Peer-reviewed

    Takashi Ohi, Motoyuki Sai, Masahiko Kikuchi, Yoshinori Hattori, Akito Tsuboi, Atsushi Hozawa, Kaori Ohmori-Matsuda, Ichiro Tsuji, Makoto Watanabe

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　218　(3)　241-249　2009/07

    DOI： 10.1620/tjem.218.241 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  475. ASSOCIATION BETWEEN NOCTURIA AND MORTALITY IN A COMMUNITY-DWELLING ELDERLY POPULATION AGED 70 YEARS AND OVER: RESULTS OF A 3-YEAR PROSPECTIVE COHORT STUDY IN JAPAN Peer-reviewed

    Nakagawa Haruo, Niu Kaijun, Hozawa Atsushi, Ikeda Yoshihiro, Kaiho Yasuhiro, Masuda-Ohmori Kaori, Nagatomi Ryoichi, Tsuji Ichiro, Arai Yoichi

    JOURNAL OF UROLOGY　181　(4)　8　2009/04

    DOI： 10.1016/S0022-5347(09)60034-3 　

    ISSN： 0022-5347

  476. Attributable Risk Fraction of Prehypertension on Cardiovascular Disease Mortality in the Japanese Population: The Ohsaki Study Peer-reviewed

    Atsushi Hozawa, Shinichi Kuriyama, Masako Kakizaki, Kaori Ohmori-Matsuda, Takayoshi Ohkubo, Ichiro Tsuji

    AMERICAN JOURNAL OF HYPERTENSION　22　(3)　267-272　2009/03

    DOI： 10.1038/ajh.2008.335 　

    ISSN： 0895-7061

  477. Circulating carotenoid concentrations and incident hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) study Peer-reviewed

    Atsushi Hozawa, David R. Jacobs, Michael W. Steffes, Myron D. Gross, Lyn M. Steffen, Duk-Hee Lee

    JOURNAL OF HYPERTENSION　27　(2)　237-242　2009/02

    DOI： 10.1097/HJH.0b013e32832258c9 　

    ISSN： 0263-6352

  478. 管理栄養士が中心となって職域において実施したメタボリックシンドローム改善のための負荷の小さな減量プログラムの効果について．

    Katsushi Yoshita, Meiko Nakagawa, Yuko Sugimori, Katsuyuki Miura, Masaru Sakurai, Takako Kami, Yusuke Arai, Miho Nozue, Rieko Tomimatsu, Hideaki Nakagawa, Hiromi Ishida

    日本栄養士会雑誌　52　(9)　821-830　2009

    DOI： 10.11379/jjda.52.821 　

    ISSN： 0013-6492 2185-6877

  479. Prognostic value of Q wave for cardiovascular death in a 19-year prospective study of the Japanese general population Peer-reviewed

    Aya Higashiyama, Atsushi Hozawa, Yoshitaka Murakami, Tomonori Okamura, Makoto Watanabe, Yasuyuki Nakamura, Takehito Hayakawa, Takashi Kadowaki, Yoshikuni Kita, Akira Okayama, Hirotsugu Ueshima, Osamu Iimura, Teruo Omae, Kazuo Ueda, Hiroshi Horibe, Kazunori Kodama, Fumiyoshi Kasagi, Shinichi Tanihara, Shigeyuki Saitoh, Kiyomi Sakata, Yosikazu Nakamura, Fumihiko Kakuno, Toshihiro Takeuchi, Mitsuru Hasebe, Fumitsugu Kusano, Takahisa Kawamoto, Masumi Minowa, Katsuhiko Kawaminami, Sohel R. Choudhury, Yutaka Kiyohara, Minoru Iida, Tsutomu Hashimoto, Atsushi Terao, Koryo Sawai, Shigeo Shibata

    Journal of Atherosclerosis and Thrombosis　16　(1)　40-50　2009

    Publisher: Japan Atherosclerosis Society

    DOI： 10.5551/jat.E606 　

    ISSN： 1880-3873 1340-3478

  480. Dietary Habits in Middle Age and Future Changes in Activities of Daily Living - NIPPON DATA80 Peer-reviewed

    Yasuyuki Nakamura, Atsushi Hozawa, Tanvir Chowdhury Turin, Naoyuki Takashima, Tomonori Okamura, Takehito Hayakawa, Yoshikuni Kita, Akira Okayama, Katsuyuki Miura, Hirotsugu Ueshima

    GERONTOLOGY　55　(6)　707-713　2009

    DOI： 10.1159/000235906 　

    ISSN： 0304-324X

  481. Absolute and Attributable Risks of Heart Failure Incidence in Relation to Optimal Risk Factors Peer-reviewed

    Aaron R. Folsom, Kazumasa Yamagishi, Atsushi Hozawa, Lloyd E. Chambless

    CIRCULATION-HEART FAILURE　2　(1)　11-17　2009/01

    DOI： 10.1161/CIRCHEARTFAILURE.108.794933 　

    ISSN： 1941-3289

  482. Risk Factor Effects and Total Mortality in Older Japanese Men in Japan and Hawaii Peer-reviewed

    Robert D. Abbott, Hirotsugu Ueshima, Atsushi Hozawa, Tomonori Okamura, Takashi Kadowaki, Katsuyuki Miura, Nagako Okuda, Yasuyuki Nakamura, Akira Okayama, Yoshikuni Kita, Beatriz L. Rodriguez, Katsuhiko Yano, J. David Curb

    ANNALS OF EPIDEMIOLOGY　18　(12)　913-918　2008/12

    DOI： 10.1016/j.annepidem.2008.09.004 　

    ISSN： 1047-2797

  483. No effect of the Trp64Arg variant of the beta(3)-adrenergic receptor gene on weight loss by diet and exercise intervention among Japanese adults Peer-reviewed

    Shinichi Kuriyama, Taichi Shimazu, Atsushi Hozawa, Shigeo Kure, Naoyuki Kurokawa, Masako Kakizaki, Toshimasa Sone, Kaori Matsuda-Ohmori, Naoki Nakaya, Hiroshi Satoh, Ichiro Tsuji

    METABOLISM-CLINICAL AND EXPERIMENTAL　57　(11)　1570-1575　2008/11

    DOI： 10.1016/j.metabol.2008.06.013 　

    ISSN： 0026-0495

  484. Predictive value of ambulatory heart rate in the Japanese general population: the Ohasama study Peer-reviewed

    Atsushi Hozawa, Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Azusa Hara, Takuo Hirose, Atsuhiro Kanno, Taku Obara, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

    JOURNAL OF HYPERTENSION　26　(8)　1571-1576　2008/08

    DOI： 10.1097/HJH.0b013e3283041172 　

    ISSN： 0263-6352

  485. Relationships between Family Histories of Stroke and of Hypertension and Stroke Mortality: NIPPON DATA80, 1980-1999 Peer-reviewed

    Aya Kadota, Tomonori Okamura, Atsushi Hozawa, Takashi Kadowaki, Yoshitaka Murakami, Takehito Hayakawa, Yoshikuni Kita, Akira Okayama, Yasuyuki Nakamura, Hirotsugu Ueshima

    HYPERTENSION RESEARCH　31　(8)　1525-1531　2008/08

    DOI： 10.1291/hypres.31.1525 　

    ISSN： 0916-9636

  486. Relationship between BMI and all-cause mortality in Japan: NIPPON DATA80 Peer-reviewed

    Atsushi Hozawa, Tomonori Okamura, Izumi Oki, Yoshitaka Murakami, Takashi Kadowaki, Koshi Nakamura, Naomi Miyamatsu, Takehito Hayakawa, Yoshikuni Kita, Yosikazu Nakamura, Yasuyuki Nakamura, Robert D. Abbott, Akira Okayama, Hirotsugu Ueshima

    OBESITY　16　(7)　1714-1717　2008/07

    DOI： 10.1038/oby.2008.237 　

    ISSN： 1930-7381

  487. Marital status and cardiovascular risk factors among middle-aged Japanese male workers: The high-risk and population strategy for occupational health promotion (HIPOP-OHP) study Peer-reviewed

    Yuko Kamon, Tomonori Okamura, Taichiro Tanaka, Atsushi Hozawa, Zentar Yamagata, Toru Takebayashi, Yukinori Kusaka, Sumio Urano, Hideaki Nakagawa, Takashi Kadowaki, Yuji Miyoshi, Hiroshi Yamato, Akira Okayama, Hirotsugu Ueshima

    JOURNAL OF OCCUPATIONAL HEALTH　50　(4)　348-356　2008/07

    DOI： 10.1539/joh.L7158 　

    ISSN： 1341-9145

  488. [Malnutrition and the risk of long-term care insurance certification or mortality. A cohort study of the Tsurugaya project]. Peer-reviewed

    Higashiguchi M, Nakaya N, Ohmori K, Shimazu T, Sone T, Hozawa A, Kuriyama S, Tsuji I

    [Nihon koshu eisei zasshi] Japanese journal of public health　55　(7)　433-439　2008/07

    Publisher: Japanese Society of Public Health

    DOI： 10.11236/jph.55.7_433 　

    ISSN： 0546-1766

    More details Close

    Objective The purpose of this study was to propose a suitable cut-off point for the serum albumin value to predict which elderly individuals are qualified for long-term care insurance certification and those at risk of death.<br/>Methods The Tsurugaya Project was a comprehensive geriatric assessment conducted for community-dwelling elderly persons aged 70 years or older in Sendai, Japan. Of those participating, the 832 from whom consent was obtained and who were not qualified for long-term care insurance certification were adopted as subjects. Cut-off points on serum albumin levels were set every 0.1 g/dL from 3.5 g/dL to 4.0 g/dL. The risk of incident certification of long-term care insurance or death (calculated by the Cox proportional hazards model), the frequency of the subjects, the sensitivity, the specificity and the positive predictive value of the category below each cut-off point were calculated.<br/>Results During 3 years follow-up, a total of 130 subjects either became certificated for long-term care insurance or died. On multivariate analyses, the risk of incident certification of long-term care insurance or death showed significantly increase with all cut-off points. The frequencies were 1.3% at 3.5 g/dL, 9.6% at 3.8 g/dL and 29.6% at 4.0 g/dL. The sensitivities were 5.4% at 3.5 g/dL, 18.5% at 3.8 g/dL and 45.4% at 4.0 g/dL. The specificities were 99.4% at 3.5 g/dL, 92.0% at 3.8 g/dL and 73.4% at 4.0 g/dL. The positive predictive values were 63.6% at 3.5 g/dL, 30.0% at 3.8 g/dL and 24.0% at 4.0 g/dL. When the serum albumin cut-off point was set to 3.8 g/dL and the highest tertile level of the serum albumin value was used as a reference category, the sex- and age-adjusted hazard ratios (95% confidence intervals) were 2.1 (1.1-3.9) in those with serum albumin ≤3.8 g/dL, 1.5 (0.9-2.5) in those with the lowest tertile level and 1.0 (0.6-1.7) in those with the middle tertile level.<br/>Conclusion This study suggested that a serum albumin value of 3.8 g/dL is a suitable cut-off point with regard to sensitivity, specificity and positive predictive value.

  489. Relation of blood pressure and all-cause mortality in 180,000 Japanese participants - Pooled analysis of 13 cohort studies Peer-reviewed

    Yoshitaka Murakami, Atsushi Hozawa, Tomonori Okamura, Hirotsugu Ueshima

    HYPERTENSION　51　(6)　1483-1491　2008/06

    DOI： 10.1161/HYPERTENSIONAHA.107.102459 　

    ISSN： 0194-911X

  490. Low-risk profile for cardiovascular disease and mortality in Japanese Peer-reviewed

    Takako Yamamoto, Yasuyuki Nakamura, Atsushi Hozawa, Tomonori Okamura, Takashi Kadowaki, Takehito Hayakawa, Yoshitaka Murakami, Yoshikuni Kita, Akira Okayama, Robert D. Abbott, Hirotsugu Ueshima

    CIRCULATION JOURNAL　72　(4)　545-550　2008/04

    DOI： 10.1253/circj.72.545 　

    ISSN： 1346-9843

  491. Alcohol intake and 19-year mortality in diabetic men: NIPPON DATA80 Peer-reviewed

    Yasuyuki Nakamura, Hirotsugu Ueshima, Aya Kadota, Atsushi Hozawa, Tomonori Okamura, Sayaka Kadowaki, Takashi Kadowaki, Takehito Hayakawa, Yoshikuni Kita, Robert D. Abbott, Akira Okayama

    CIRCULATION　117　(11)　2008/03

    ISSN： 0009-7322

    eISSN： 1524-4539

  492. Lower levels of serum albumin and total cholesterol associated with decline in activities of daily living and excess mortality in a 12-year cohort study of elderly Japanese Peer-reviewed

    Tomonori Okamura, Takehito Hayakawa, Atsushi Hozawa, Takashi Kadowaki, Yoshitaka Murakami, Yoshikuni Kita, Robert D. Abbott, Akira Okayama, Hirotsugu Ueshima

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY　56　(3)　529-535　2008/03

    DOI： 10.1111/j.1532-5415.2007.01549.x 　

    ISSN： 0002-8614

  493. Home blood pressure is associated with depressive symptoms in an elderly population aged 70 years and over: A population-based, cross-sectional analysis Peer-reviewed

    Kaijun Niu, Atsushi Hozawa, Shuichi Awata, Hui Guo, Shinichi Kuriyama, Toru Sek, Kaori Ohmori-Matsuda, Naoki Nakaya, Satoru Ebihara, Yun Wang, Ichiro Tsuji, Ryoichi Nagatomi

    HYPERTENSION RESEARCH　31　(3)　409-416　2008/03

    DOI： 10.1291/hypres.31.409 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  494. Cause-specific and all-cause mortality in individuals with low risk status for cardiovascular disease in the Japanese population,NIPPON DATA80. Peer-reviewed

    Yamamoto T, Nakamura Y, Hozawa A, Okamura T, Kadowaki T, Hayakawa T, Murakami Y, Kita Y, Okayama A, Abbott RD, Ueshima H

    Cir J　72　(4)　545-550　2008

  495. Longitudinal association of serum carotenoids and tocopherols with hostility - The CARDIA study Peer-reviewed

    Tetsuya Ohira, Atsushi Hozawa, Carlos Iribarren, Martha L. Daviglus, Karen A. Matthews, Myron D. Gross, David R. Jacobs

    AMERICAN JOURNAL OF EPIDEMIOLOGY　167　(1)　42-50　2008/01

    DOI： 10.1093/aje/kwm267 　

    ISSN： 0002-9262

  496. Serum C-Reactive Protein Even at Very Low (&lt; 1.0 mg/l) Concentration Is Associated with Physical Performance in a Community-Based Elderly Population Aged 70 Years and Over Peer-reviewed

    Kaijun Niu, Atsushi Hozawa, Hui Guo, Shinichi Kuriyama, Satoru Ebihara, Guang Yang, Kaori Ohmori-Matsuda, Naoki Nakaya, Hideko Takahashi, Kazuki Fujita, Shirong Wen, Hiroyuki Arai, Ichiro Tsuji, Ryoichi Nagatomi

    GERONTOLOGY　54　(5)　260-267　2008

    DOI： 10.1159/000134286 　

    ISSN： 0304-324X

  497. Incorporating self-blood pressure measurements at home in the guideline from the Ohasama study Peer-reviewed

    Takayoshi Ohkubo, Masahiro Kikuya, Kei Asayama, Hirohito Metoki, Azusa Hara, Ryusuke Inoue, Taku Obara, Takuo Hirose, Rieko Hatanaka, Atsushi Hozawa, Haruhisa Hoshi, Junichiro Hashimoto, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

    BLOOD PRESSURE MONITORING　12　(6)　407-409　2007/12

    DOI： 10.1097/MBP.0b013e328244e8a7 　

    ISSN： 1359-5237

  498. Joint impact of smoking and hypertension on cardiovascular disease and all-cause mortality in Japan: NIPPON DATA80, a 19-year follow-up Peer-reviewed

    Atsushi Hozawa, Tomonori Okamura, Yoshitaka Murakami, Takashi Kadowaki, Koshi Nakamura, Takehito Hayakawa, Yoshikuni Kita, Yasuyuki Nakamura, Robert D. Abbott, Akira Okayama, Hirotsugu Ueshima

    HYPERTENSION RESEARCH　30　(12)　1169-1175　2007/12

    DOI： 10.1291/hypres.30.1169 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  499. The proportion of individuals with obesity-induced hypertension among total hypertensives in a general Japanese population: NIPPON DATA80, 90 Peer-reviewed

    Koshi Nakamura, Tomonori Okamura, Takehito Hayakawa, Atsushi Hozawa, Takashi Kadowaki, Yoshitaka Murakami, Yoshikuni Kita, Akira Okayama, Hirotsugu Ueshima

    EUROPEAN JOURNAL OF EPIDEMIOLOGY　22　(10)　691-698　2007/10

    DOI： 10.1007/s10654-007-9168-4 　

    ISSN： 0393-2990

  500. Is weak association between cigarette smoking and cardiovascular disease mortality observed in Japan explained by low total cholesterol? NIPPON DATA80 Peer-reviewed

    Atsushi Hozawa, Tomonori Okamura, Takashi Kadowaki, Yoshitaka Murakami, Koshi Nakamura, Takehito Hayakawa, Yoshikuni Kita, Yasuyuki Nakamura, Akira Okayama, Hirotsugu Ueshima

    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY　36　(5)　1060-1067　2007/10

    DOI： 10.1093/ije/dym169 　

    ISSN： 0300-5771

    eISSN： 1464-3685

  501. Response to letter by Walsh et al [14]

    Atsushi Hozawa, Tomonori Okamura, Hirotsugu Ueshima

    Stroke　38　(9)　e93　2007/09

    DOI： 10.1161/STROKEAHA.107.492181 　

    ISSN： 0039-2499

  502. Why a sex difference in age-adjusted relationship between height and stroke mortality? Response Peer-reviewed

    Atsushi Hozawa, Tomonori Okamura, Hirotsugu Ueshima

    STROKE　38　(9)　E93-E93　2007/09

    DOI： 10.1161/STROKEAHA.107.492181 　

    ISSN： 0039-2499

  503. Association between physical activity and urinary incontinence in a community-based elderly population aged 70 years and over Peer-reviewed

    Akio Kikuchi, Kaijun Niu, Yoshihiro Ikeda, Atsushi Hozawa, Haruo Nakagawa, Hui Guo, Kaori Ohmori-Matsuda, Guang Yang, Arta Farmawati, Ashkan Sami, Yoichi Arai, Ichiro Tsuji, Ryoichi Nagatomi

    EUROPEAN UROLOGY　52　(3)　868-875　2007/09

    DOI： 10.1016/j.eururo.2007.03.041 　

    ISSN： 0302-2838

  504. The proportion of individuals with alcohol-induced hypertension among hypertensives in a general Japanese population: NIPPON DATA90 Peer-reviewed

    Koshi Nakamura, Tomonori Okamura, Takehito Hayakawa, Atsushi Hozawa, Takashi Kadowaki, Yoshitaka Murakami, Yoshikuni Kita, Akira Okayama, Hirotsugu Ueshima

    HYPERTENSION RESEARCH　30　(8)　663-668　2007/08

    DOI： 10.1291/hypres.30.663 　

    ISSN： 0916-9636

  505. Dietary patterns and cardiovascular disease mortality in Japan: a prospective cohort study Peer-reviewed

    Taichi Shimazu, Shinichi Kuriyama, Atsushi Hozawa, Kaori Ohmori, Yuki Sato, Naoki Nakaya, Yoshikazu Nishino, Yoshitaka Tsubono, Ichiro Tsuji

    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY　36　(3)　600-609　2007/06

    DOI： 10.1093/ije/dym005 　

    ISSN： 0300-5771

  506. Relationship between metabolic risk factor clustering and cardiovascular mortality stratified by high blood glucose and obesity - NIPPON DATA90, 1990-2000 Peer-reviewed

    Aya Kadota, Atsushi Hozawa, Tomonori Okamura, Takashi Kadowak, Koshi Nakmaura, Yoshitaka Murakami, Takehito Hayakawa, Yoshikuni Kita, Akira Okayama, Yasuyuki Nakamura, Atsunori Kashiwagi, Hirotsugu Ueshima

    DIABETES CARE　30　(6)　1533-1538　2007/06

    DOI： 10.2337/dc06-2074 　

    ISSN： 0149-5992

  507. Effect of combined cardiovascular risk factors on individual and population medical expenditures - A 10-year cohort study of National Health Insurance in a Japanese population Peer-reviewed

    Tomonori Okamura, Koshi Nakamura, Hideyuki Kanda, Takehito Hayakawa, Atsushi Hozawa, Yoshitaka Murakami, Takashi Kadowaki, Yoshikuni Kita, Akira Okayama, Hirotsugu Ueshima

    CIRCULATION JOURNAL　71　(6)　807-813　2007/06

    DOI： 10.1253/circj.71.807 　

    ISSN： 1346-9843

  508. Dietary intake of fatty acids and serum C-reactive protein in Japanese.

    Satoko Yoneyama, Katsuyuki Miura, Satoshi Sasaki, Katsushi Yoshita, Yuko Morikawa, Masao Ishizaki, Teruhiko Kido, Yuchi Naruse, Hideaki Nakagawa

    Journal of epidemiology　17　(3)　86-92　2007/05

    ISSN： 0917-5040

    More details Close

    BACKGROUND: Inflammation has been established as a risk factor for cardiovascular diseases. The relationships of polyunsaturated fatty acids (PUFAs) and monounsaturated fatty acids to inflammation are still controversial in Western populations. The relationships are not clear in Japanese whose intake of seafood-based long-chain n-3 PUFAs is high. METHODS: We conducted a cross-sectional epidemiologic study in the Japanese population (1,556 men and 1,461 women aged 35-60). Serum high sensitivity C-reactive protein (CRP) was measured, and intakes of 7 specific fatty acids (% of energy) were evaluated by a validated self-administered dietary history questionnaire. RESULTS: CRP was significantly and inversely related to the intakes of oleic acid (p=0.008) and alpha-linolenic acid (p=0.026) in women after adjustment for confounding factors. A multiple regression analysis showed that, especially in the middle tertile of long-chain n-3 PUFAs (eicosapentaenoic acid and docosahexaenoic acid) intake, CRP was inversely related to the intake of oleic acid and linoleic acid in both sexes and to the intake of alpha-linolenic acid in women. CONCLUSION: Intakes of oleic acid, linoleic acid, and alpha-linolenic acid would reduce serum CRP, especially when the intake of long-chain n-3 PUFAs is at a moderate level in Japanese.

  509. Does self-reported history of hypertension predict cardiovascular death? Comparison with blood pressure measurement in a 19-year prospective study Peer-reviewed

    Aya Higashiyama, Yoshitaka Murakami, Atsushi Hozawa, Tomonori Okamura, Takehito Hayakawa, Takashi Kadowaki, Yoshikuni Kita, Akira Okayama, Hirotsugu Ueshima

    JOURNAL OF HYPERTENSION　25　(5)　959-964　2007/05

    DOI： 10.1097/HJH.0b013e3280586735 　

    ISSN： 0263-6352

  510. The joint impact of cardiovascular risk factors upon medical costs Peer-reviewed

    Kaori Ohmori-Matsuda, Shinichi Kuriyama, Atsushi Hozawa, Naoki Nakaya, Taichi Shimazu, Ichiro Tsuji

    PREVENTIVE MEDICINE　44　(4)　349-355　2007/04

    DOI： 10.1016/j.ypmed.2006.11.020 　

    ISSN： 0091-7435

  511. Relationships of circulating carotenoid concentrations with several markers of inflammation, oxidative stress, and endothelial dysfunction: The Coronary Artery Risk Development in Young Adults (CARDIA)/Young Adult Longitudinal Trends in Antioxidants (YALTA) Study Peer-reviewed

    Atsushi Hozawa, David R. Jacobs, Michael W. Steffes, Myron D. Gross, Lyn M. Steffen, Duk-Hee Lee

    CLINICAL CHEMISTRY　53　(3)　447-455　2007/03

    DOI： 10.1373/clinchem.2006.074930 　

    ISSN： 0009-9147

  512. Absolute and attributable risks of cardiovascular disease incidence in relation to optimal and borderline risk factors - Comparison of African American with white subjects - Atherosclerosis risk in communities study Peer-reviewed

    Atsushi Hozawa, Aaron R. Folsom, A. Richey Sharrett, Lloyd E. Chambless

    ARCHIVES OF INTERNAL MEDICINE　167　(6)　573-579　2007/03

    DOI： 10.1001/archinte.167.6.573 　

    ISSN： 0003-9926

  513. Life expectancy among Japanese of different smoking status in Japan: NIPPON DATA80 Peer-reviewed

    Yoshitaka Murakami, Hirotsugu Ueshima, Tomonori Okamura, Takashi Kadowaki, Atsushi Hozawa, Yoshikuni Kita, Takehito Hayakawa, Akira Okayama

    JOURNAL OF EPIDEMIOLOGY　17　(2)　31-37　2007/03

    DOI： 10.2188/jea.17.31 　

    ISSN： 0917-5040

  514. Height and the waist circumference criterion in the metabolic syndrome in Japanese men Peer-reviewed

    Sayaka Kadowaki, Takashi Kadowaki, Akira Sekikawa, Tomonori Okamura, Tomoko Takamiya, Yasuyuki Nakamura, Aiman El-Saed, Atsushi Hozawa, Robert D. Abbott, Hirotsugu Ueshima

    CIRCULATION　115　(8)　E232-E232　2007/02

    ISSN： 0009-7322

  515. Serum-gamma-glutamyltransferase (GGT) predicts cardiovascular disease mortality among Japanese women whose prevalence of drinking was extremely low. Peer-reviewed

    Hozawa A, Okamura T, Kadowaki T, Murakami Y, Nakamura K, Hayakawa T, Kita Y, Nakamura Y, Okayama A, Ueshima H

    Atherosclerosis　194　(2)　Serum-gamma-glutamyltransferas　2007

  516. Relation of adult height with stroke mortality in Japan NIPPON DATA80 Peer-reviewed

    Atsushi Hozawa, Yoshitaka Murakami, Tomonori Okamura, Takashi Kadowaki, Koshi Nakamura, Takehito Hayakawa, Yoshikuni Kita, Yasuyuki Nakamura, Akira Okayama, Hirotsugu Ueshima

    STROKE　38　(1)　22-26　2007/01

    DOI： 10.1161/01.STR.0000251806.01676.60 　

    ISSN： 0039-2499

  517. Benefit of home blood pressure measurement after a finding of high blood pressure at community screening. Peer-reviewed

    Atsushi Hozawa, Taichi Shimazu, Shinichi Kuriyama, Ichiro Tsuji

    JOURNAL OF HYPERTENSION　24　210-210　2006/12

    ISSN： 0263-6352

  518. Lung function and ischemic stroke incidence - The atherosclerosis risk in communities study Peer-reviewed

    Atsushi Hozawa, Joanne L. Billings, Eyal Shahar, Tetsuya Ohira, Wayne D. Rosamond, Aaron R. Folsom

    CHEST　130　(6)　1642-1649　2006/12

    DOI： 10.1378/chest.130.6.1642 　

    ISSN： 0012-3692

  519. 高齢者のうつカウンセリング治療によるLUTSの変化 Peer-reviewed

    池田義弘, 今西里佳, 中川晴夫, 竹本淳, 松下真史, 荒井陽一, 小泉弥生, 粟田主一, 大森芳, 寶沢篤, 西野善一, 栗山進一, 辻一郎

    日本排尿機能学会誌　17　(1)　171-171　2006/09

  520. Impact of non-dietary nutrients intake on misclassification in the estimation of nutrient intake in epidemiologic study Peer-reviewed

    Mikiko Ogata, Shinichi Kuriyama, Yuki Sato, Taichi Shimazu, Naoki Nakaya, Kaori Ohmori, Atsushi Hozawa, Ichiro Tsuji

    JOURNAL OF EPIDEMIOLOGY　16　(5)　193-200　2006/09

    DOI： 10.2188/jea.16.193 　

    ISSN： 0917-5040

  521. 高齢女性の性に関する疫学調査

    中川晴夫, 池田義弘, 竹本淳, 大森芳, 寶澤篤, 辻一郎, 荒井陽一

    日本性機能学会雑誌　21　(2)　212-212　2006/08

  522. Dietary factors related to higher plasma fibrinogen levels of Japanese-Americans in Hawaii compared with Japanese in Japan Peer-reviewed

    Katsuyuki Miura, Hideaki Nakagawa, Hirotsugu Ueshima, Akira Okayama, Shigeyuki Saitoh, J. David Curb, Beatriz L. Rodriguez, Kiyomi Sakata, Nagako Okuda, Katsushi Yoshita, Jeremiah Stamler

    Arteriosclerosis, Thrombosis, and Vascular Biology　26　(7)　1674-1679　2006/07

    DOI： 10.1161/01.ATV.0000225701.20965.b9 　

    ISSN： 1079-5642

  523. Dietary long-chain n-3 fatty acids of marine origin and serum C-reactive protein concentrations are associated in a population with a diet rich in marine products Peer-reviewed

    Kaijun Niu, Atsushi Hozawa, Shinichi Kuriyama, Kaori Ohmori-Matsuda, Taichi Shimazu, Naoki Nakaya, Kazuki Fujita, Ichiro Tsuji, Ryoichi Nagatomi

    AMERICAN JOURNAL OF CLINICAL NUTRITION　84　(1)　223-229　2006/07

    DOI： 10.1093/ajcn/84.1.223 　

    ISSN： 0002-9165

  524. Obesity and depressive symptoms in elderly Japanese: The Tsurugaya Project Peer-reviewed

    S Kuriyama, Y Koizumi, K Matsuda-Ohmori, T Seki, T Shimazu, A Hozawa, S Awata, Tsuji, I

    JOURNAL OF PSYCHOSOMATIC RESEARCH　60　(3)　229-235　2006/03

    DOI： 10.1016/j.jpsychores.2005.07.010 　

    ISSN： 0022-3999

  525. Dietary intakes and plasma 8-iso-prostaglandin F-2 alpha concentrations in community-dwelling elderly Japanese: The Tsurugaya Project Peer-reviewed

    Shinichi Kuriyama, Satoru Ebihara, Atsushi Hozawa, Kaori Ohmori, Kayoko Kurashima, Naoki Nakaya, Toshifumi Matsui, Hiroyuki Arai, Yoshitaka Tsubono, Hidetada Sasaki, Ichiro Tsuji

    INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH　76　(2)　87-94　2006/03

    DOI： 10.1024/0300-9831.76.2.87 　

    ISSN： 0300-9831

  526. Green tea consumption and cognitive function: a cross-sectional study from the Tsurugaya Project Peer-reviewed

    S Kuriyama, A Hozawa, K Ohmori, T Shimazu, T Matsui, S Ebihara, S Awata, R Nagatomi, H Arai, Tsuji, I

    AMERICAN JOURNAL OF CLINICAL NUTRITION　83　(2)　355-361　2006/02

    DOI： 10.1093/ajcn/83.2.355 　

    ISSN： 0002-9165

  527. [Comparison of intensive and moderate individual life-style intervention programs for overweight or obese persons with fasting glucose levels of 95-125 mg/dl in Japan]. Peer-reviewed

    Kuriyama S, Shimazu T, Hozawa A, Yabe M, Tasaki M, Mononaga Y, Sakai M, Miura C, Ito F, Ito T, Yabe H, Nitta S, Suzuki R, Fujita K, Nagatomi R, Tsuji I

    [Nihon koshu eisei zasshi] Japanese journal of public health　53　(2)　122-132　2006/02

    DOI： 10.11236/jph.53.2_122 　

    ISSN： 0546-1766

    More details Close

    OBJECTIVES: There are considerable differences in individual health education programs for persons at high risk of type 2 diabetes between ordinary Japanese life-style modification programs and the Diabetes Prevention Program in the US, the former being relatively moderate and the latter more intensive. We therefore compared the effectiveness of intensive and moderate intervention, focusing on the frequency of individual educational classes. METHODS: The subjects were men and women aged 44-69 years living in Nishiaizu town, Fukushima prefecture in Japan. Their fasting plasma glucose concentration was between 95 and 125 mg/dl at health examinations conducted in 2002 or 2003. They also had a body mass index (BMI) of 23.0 or higher, a fasting plasma glucose concentration of 125 mg/dl or lower and a post-load plasma glucose concentration (2 h) of 199 mg/dl or lower in the 2004 survey. We assigned the subjects according to their residences to an intensive life-style intervention group (two education classes per month; n = 11) or a moderate intervention group (one education class per month; n = 14). The main outcome measure was the change in body weight after 6 months of intervention. RESULTS: The loss of body weight was -3.5 kg (P< .0001) in the intensive intervention group and -1.8 kg (P = 0.02) in the moderate group, and the net difference in body weight loss between the groups was -2.0 kg (95% confidence interval -4.0 to -0.05; P = 0.045) after adjustment for age, sex, and baseline body weight. BMI and subcutaneous fat area showed similar results. The post-load plasma glucose concentration (2 h) and other tested values showed no significant net change between the two groups. CONCLUSIONS: Intensive and moderate intervention both reduced body weight in overweight or obese persons at high risk of type 2 diabetes. The intensive intervention, two sessions of individual education classes per month, was significantly more effective than the moderate one for reducing body weight.

  528. MP-292 高齢者の男性性機能に関する疫学調査と治療誘導による受診率の検討(一般演題ポスター,第94回日本泌尿器科学会総会)

    中川 晴夫, 池田 義弘, 竹本 淳, 大森 芳, 寳澤 篤, 斉藤 敏典, 辻 一郎, 荒井 陽一

    日本泌尿器科学会雑誌　97　(2)　439-439　2006

    Publisher: 一般社団法人 日本泌尿器科学会

    DOI： 10.5980/jpnjurol.97.439_4 　

  529. 在宅高齢者の身体能力別にみた余暇身体活動レベルと医療費との関連 鶴ヶ谷プロジェクト (体力科学)

    楊光, 牛凱軍, 藤田和樹, 寶澤篤, 大森芳, 海老原覚, 三浦千早, 辻一郎, 永富良一

    体力科学　55　(6)　880-880　2006

    Publisher:

    ISSN： 0039-906X

    eISSN： 1881-4751

  530. Association between depressive symptoms and cerebrovascular lesions on MRI in community-dwelling elderly individuals Peer-reviewed

    Toru Seki, Shuichi Awata, Yayoi Koizumi, Shigeo Kinomura, Yasuyuki Taki, Atsushi Hozawa, Kaori Ohmori, Shinichi Kuriyama, Hiroshi Fukuda, Ichiro Tsuji

    Japanese Journal of Geriatrics　43　(1)　102-107　2006

    Publisher: Japan Geriatrics Society

    DOI： 10.3143/geriatrics.43.102 　

    ISSN： 0300-9173

  531. Association between social support and depression status in the elderly: Results of a 1-year community-based prospective cohort study in Japan Peer-reviewed

    Y Koizumi, S Awata, S Kuriyama, K Ohmori, A Hozawa, T Seki, H Matsuoka, Tsuji, I

    PSYCHIATRY AND CLINICAL NEUROSCIENCES　59　(5)　563-569　2005/10

    DOI： 10.1111/j.1440-1819.2005.01415.x 　

    ISSN： 1323-1316

  532. Factors affecting home-measured resting heart rate in the general population - The Ohasama study Peer-reviewed

    J Yamaguchi, A Hozawa, T Ohkubo, M Kikuya, T Ugajin, K Ohmori, J Hashimoto, H Hoshi, H Satoh, Tsuji, I, Y Imai

    AMERICAN JOURNAL OF HYPERTENSION　18　(9)　1218-1225　2005/09

    DOI： 10.1016/j.amjhyper.2005.04.009 　

    ISSN： 0895-7061

  533. Influence of leisure-time physical activity on the relationship between C-reactive protein and hypertension in a community-based elderly population of Japan: The Tsurugaya Project Peer-reviewed

    K Niu, A Hozawa, K Fujita, K Ohmori, M Okutsu, S Kuriyama, Tsuji, I, R Nagatomi

    HYPERTENSION RESEARCH　28　(9)　747-754　2005/09

    DOI： 10.1291/hypres.28.747 　

    ISSN： 0916-9636

  534. White-coat hypertension as a risk factor for the development of home hypertension - The Ohasama Study Peer-reviewed

    T Ugajin, A Hozawa, T Ohkubo, K Asayama, M Kikuya, T Obara, H Metoki, H Hoshi, J Hashimoto, K Totsune, H Satoh, Tsuji, I, Y Imai

    ARCHIVES OF INTERNAL MEDICINE　165　(13)　1541-1546　2005/07

    DOI： 10.1001/archinte.165.13.1541 　

    ISSN： 0003-9926

  535. 都市部住宅地域における在宅高齢者の口腔状態 鶴ヶ谷プロジェクト Peer-reviewed

    大井孝, 菊池雅彦, 玉澤佳純, 服部佳功, 坪井明人, 高津匡樹, 佐藤智昭, 岩松正明, 伊藤進太郎, 小牧健一朗, 山口哲史, 寶沢篤, 辻一郎, 渡邉誠

    東北大学歯学雑誌　24　(1)　16-23　2005/06

  536. Factors associated with suicidal ideation in an elderly urban Japanese population: A community-based, cross-sectional study Peer-reviewed

    S Awata, T Seki, Y Koizumi, S Sato, A Hozawa, K Omori, S Kuriyama, H Arai, R Nagatomi, H Matsuoka, Tsuji, I

    PSYCHIATRY AND CLINICAL NEUROSCIENCES　59　(3)　327-336　2005/06

    DOI： 10.1111/j.1440-1819.2005.01378.x 　

    ISSN： 1323-1316

  537. Fruit and vegetable consumption and risk of colorectal cancer in Japan: The Miyagi Cohort Study Peer-reviewed

    Y Sato, Y Tsubono, N Nakaya, K Ogawa, K Kurashima, S Kuriyama, A Hozawa, Y Nishino, D Shibuya, Tsuji, I

    PUBLIC HEALTH NUTRITION　8　(3)　309-314　2005/05

    DOI： 10.1079/PHN2004681 　

    ISSN： 1368-9800

  538. Personality and mortality from ischemic heart disease and stroke Peer-reviewed

    N Nakaya, Y Tsubono, T Hosokawa, A Hozawa, S Kuriyama, S Fukudo, Tsuji, I

    CLINICAL AND EXPERIMENTAL HYPERTENSION　27　(2-3)　297-305　2005/02

    DOI： 10.1081/CEH-200048930 　

    ISSN： 1064-1963

  539. 高齢者の男性性機能に関する疫学的調査と介入による治療誘導(第93回日本泌尿器科学会総会)

    中川 晴夫, 池田 義弘, 竹本 淳, 大森 芳, 寶澤 篤, 辻 一郎, 荒井 陽一

    日本泌尿器科学会雑誌　96　(2)　185-185　2005

    Publisher: 一般社団法人 日本泌尿器科学会

    DOI： 10.5980/jpnjurol.96.185_3 　

  540. Obesity and risk of cancer in Japan Peer-reviewed

    S Kuriyama, Y Tsubono, A Hozawa, T Shimazu, Y Suzuki, Y Koizumi, Y Suzuki, K Ohmori, Y Nishino, Tsuji, I

    INTERNATIONAL JOURNAL OF CANCER　113　(1)　148-157　2005/01

    DOI： 10.1002/ijc.20529 　

    ISSN： 0020-7136

  541. The relationship between body mass index and a plasma lipid peroxidation biomarker in an older, healthy Asian community Peer-reviewed

    K Ohmori, S Ebihara, S Kuriyama, T Ugajin, M Ogata, A Hozawa, T Matsui, Y Tsubono, H Arai, H Sasaki, Tsuji, I

    ANNALS OF EPIDEMIOLOGY　15　(1)　80-84　2005/01

    DOI： 10.1016/j.annepidem.2004.04.001 　

    ISSN： 1047-2797

  542. Modifiable factors for the length of life with disability before death: Mortality retrospective study in Japan Peer-reviewed

    K Ohmori, S Kuriyama, A Hozawa, T Ohkubo, Y Tsubono, Tsuji, I

    GERONTOLOGY　51　(3)　186-191　2005

    DOI： 10.1159/000083992 　

    ISSN： 0304-324X

  543. Joint impact of health risks on health care charges: 7-year follow-up of National Health Insurance beneficiaries in Japan (the Ohsaki Study) Peer-reviewed

    S Kuriyama, A Hozawa, K Ohmori, Y Suzuki, Y Nishino, K Fujita, Y Tsubono, Tsuji, I

    PREVENTIVE MEDICINE　39　(6)　1194-1199　2004/12

    DOI： 10.1016/j.ypmed.2004.04.033 　

    ISSN： 0091-7435

  544. Association between angiotensin II type 1 receptor gene polymorphism and essential hypertension: The Ohasama Study Peer-reviewed

    K Sugimoto, T Katsuya, T Ohkubo, A Hozawa, K Yamamoto, A Matsuo, H Rakugi, Tsuji, I, Y Imai, T Ogihara

    HYPERTENSION RESEARCH　27　(8)　551-556　2004/08

    DOI： 10.1291/hypres.27.551 　

    ISSN： 0916-9636

  545. The evaluation of materials to provide health-related information as a population strategy in the worksite: The high-risk and population strategy for occupational health promotion (HIPOP-OHP) study. International-journal

    Katsushi Yoshita, Taichiro Tanaka, Yuriko Kikuchi, Toru Takebayashi, Nagako Chiba, Junko Tamaki, Katsuyuki Miura, Takashi Kadowaki, Tomonori Okamura, Hirotsugu Ueshima

    Environmental health and preventive medicine　9　(4)　144-51　2004/07

    DOI： 10.1007/BF02898093 　

    More details Close

    OBJECTIVE: To examine the effectiveness of newly developed materials for providing health-related information to the worksite population, we compared the amount of attention that employees paid to the materials. METHODS: Study subjects were 2,361 employees in six companies participating in an intervention program between 2002 and 2003. Three kinds of media were used as tools for providing health information: [1] Point Of Purchase advertising menus (POP menus) were placed on all tables in company restaurants, [2] posters were put on walls and [3] leaflets were distributed at health-related events. One year or more after the introduction of these media, we compared the amount of attention paid to each type of medium. RESULTS: Amongst the three types of media, the POP menu drew the most attention, although results were not consistent in all gender and company groups. Every piece of information provided by the POP menus was "always" or "almost always" read by 41% of the men and 51% of the women surveyed. The corresponding rate for posters was 30% in men and 32% in women. For leaflets, only 16% of men and 22% of women read almost all of the leaflets. More attention was paid to the POP menu when the sample was women, older, and ate at the company restaurant at least three times a week. CONCLUSION: The POP menu may provide health-related information to a broader range of people than posters and leaflets, therefore, it is an effective material for population strategy.

  546. [A survey regarding the implementation of cancer screening among municipalities in Japan]. Peer-reviewed

    Nakaya N, Ohmori K, Suzuki Y, Hozawa A, Kuriyama S, Tsubono Y, Tsuji I

    [Nihon koshu eisei zasshi] Japanese journal of public health　51　(7)　530-539　2004/07

    DOI： 10.11236/jph.51.7_530 　

    ISSN： 0546-1766

  547. [Ambulatory blood pressure monitoring and self-measurement of blood pressure at home]. Peer-reviewed

    Hozawa A, Imai Y

    Nihon rinsho. Japanese journal of clinical medicine　62 Suppl 3　403-407　2004/03

    ISSN： 0047-1852

  548. Progress report on the HOMED-BP study: Hypertension objective treatment based on measurement by electrical devices of blood pressure study Peer-reviewed

    Y Aoki, K Asayama, T Ohkubo, T Nishimura, M Kikuya, H Metoki, A Hozawa, J Hashimoto, M Michimata, M Matsubara, T Araki, Y Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION　26　(2)　119-127　2004/02

    DOI： 10.1081/CEH-120028548 　

    ISSN： 1064-1963

  549. Follow-up and mortality profiles in the Miyagi Cohort Study Peer-reviewed

    Tsuji, I, Y Nishino, Y Tsubono, Y Suzuki, A Hozawa, N Nakaya, K Fujita, S Kuriyama, D Shibuya, A Fukao, S Hisamichi

    JOURNAL OF EPIDEMIOLOGY　14　S2-S6　2004/02

    DOI： 10.2188/jea.14.S2 　

    ISSN： 0917-5040

  550. Cancer incidence profiles in the Miyagi Cohort Study Peer-reviewed

    Y Nishino, Y Suzuki, K Ohmori, A Hozawa, K Ogawa, S Kuriyama, Y Tsubono, D Shibuya, Tsuji, I, A Fukao, S Hisamichi

    JOURNAL OF EPIDEMIOLOGY　14　S7-S11　2004/02

    DOI： 10.2188/jea.14.S7 　

    ISSN： 0917-5040

  551. Health practices and mortality in Japan: Combined effects of smoking, drinking, walking and body mass index in the Miyagi Cohort Study Peer-reviewed

    Y Tsubono, Y Koizumi, N Nakaya, K Fujita, H Takahashi, A Hozawa, Y Suzuki, S Kuriyama, Tsuji, I, A Fukao, S Hisamichi

    JOURNAL OF EPIDEMIOLOGY　14　S39-S45　2004/02

    DOI： 10.2188/jea.14.S39 　

    ISSN： 0917-5040

  552. Association between social support and depression in the elderly Japanese population Peer-reviewed

    Koizumi Yayoi, Arai Hiroyuki, Tsuji Ichiro, Awata Shuichi, Seki Toru, Nakaya Naoki, Kuriyama Shinichi, Suzuki Yoshinori, Ohmori Kaori, Hozawa Atsushi, Ebihara Satoru

    Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics　41　(4)　426-433　2004

    Publisher: The Japan Geriatrics Society

    DOI： 10.3143/geriatrics.41.426 　

    ISSN： 0300-9173

    More details Close

    To determine the association between social support and depression in elderly Japanese, we conducted a Comprehensive Geriatric Assessment among residents aged 70 years or over.<br>Out of 2, 730 eligible subjects, 1, 179 participated in the survey and 1, 146 (480 men and 666 women) were analyzed. The Geriatric Depression Scale (GDS) was used to estimate depression status. The subjects were divided into two groups: depressive (GDS>11 or taking antidepressant drugs) and non-depressive (GDS<11). Various levels of social support were assessed by the following questions: Do you have someone (1) whom you can consult when you are in trouble? (2) whom you can consult when your physical condition is not good? (3) who can help you in daily housework? (4) who can take you to a hospital when you don't feel well? (5) who can take care of you when you are ill in bed? In multivariate logistic regression analysis, the calculated odds ratios (95% CIs) for the lack of each type of social support for depression status were: (1) 2.5 (1.5-4.1), (2) 1.9 (1.1-3.2), (3) 2.7 (1.7-4.4), (4) 1.9 (1.1-3.2), (5) 2.8 (1.6-4.9) in men, and (1) 1.2 (0.8-1.8), (2) 1.2 (0.8-1.8), (3) 1.4 (1.0-2.0), (4) 1.6 (1.1-2.3), (5) 2.0 (1.4-2.9) in women.<br>A significant association was found between social support and depression in this elderly population. We also found that this association was stronger in men.

  553. Personality and the risk of cancer Peer-reviewed

    N Nakaya, Y Tsubono, T Hosokawa, Y Nishino, T Ohkubo, A Hozawa, D Shibuya, S Fukudo, A Fukao, Tsuji, I, S Hisamichi

    JOURNAL OF THE NATIONAL CANCER INSTITUTE　95　(11)　799-805　2003/06

    ISSN： 0027-8874

  554. Increased risk of irritable bowel syndrome in depressive individuals in elderly population. Peer-reviewed

    Nakaya Naoki, Saito Kumi, Kurashima Kyoko, Hozawa Atsushi, Kanazawa Motoyori, Fukudo Shin, Tsuji Ichiro

    Gastroenterology　124　A86-A86　2003/04

  555. Genetic risk factors for cerebral infarction using data from a large scale genetic epidemiollogical study. the Ohasama Study. Peer-reviewed

    Katsuya Tomohiro, Sugimoto Ken, Hozawa Atsushi, Ohkubo Takayoshi, Yamamoto Koichi, Matsuo Akiko, Ishikawa Kazuhiko, Matsubora Mitsunobu, Rakugi Hiromi, Tsuji Ichiro, Imai Yutaka, Ogihara Toshio

    Geriatrics and Gerontology International　3　150-153　2003/04

  556. Therapeutic effects of evening administration of guanabenz and clonidine on morning hypertension: evaluation using home-based blood pressure measurements Peer-reviewed

    J Hashimoto, K Chonan, Y Aoki, T Ugajin, J Yamaguchi, T Nishimura, M Kikuya, M Michimata, M Matsubara, T Araki, A Hozawa, T Ohkubo, Y Imai

    JOURNAL OF HYPERTENSION　21　(4)　805-811　2003/04

    DOI： 10.1097/01.hjh.0000052481.18130.69 　

    ISSN： 0263-6352

  557. Effects of exercise training on physical activity in older people: a randomized controlled trial Peer-reviewed

    K Fujita, R Nagatomi, A Hozawa, T Ohkubo, K Sato, Y Anzai, C Sauvaget, Y Watanabe, A Tamagawa, Tsuji, I

    JOURNAL OF EPIDEMIOLOGY　13　(2)　120-126　2003/03

    DOI： 10.2188/jea.13.120 　

    ISSN： 0917-5040

  558. Heart rate measurement and outcome Peer-reviewed

    Y Imai, A Hozawa, T Ohkubo, K Ohmori, M Kikuya, J Hashimoto, M Michimata, M Matsubara, J Yamaguchi, T Ugajin, T Araki, Tsuji, I

    BLOOD PRESSURE MONITORING　8　(1)　53-55　2003/02

    DOI： 10.1097/01.mbp.0000057017.67622.82 　

    ISSN： 1359-5237

  559. A/C-1166 gene polymorphism of the angiotensin II type 1 receptor (AT1) and ambulatory blood pressure: the Ohasama Study Peer-reviewed

    M Kikuya, K Sugimoto, T Katsuya, M Suzuki, T Sato, J Funahashi, R Katoh, Kazama, I, M Michimata, T Araki, A Hozawa, Tsuji, I, T Ogihara, T Yanagisawa, Y Imai, M Matsubara

    HYPERTENSION RESEARCH　26　(2)　141-145　2003/02

    DOI： 10.1291/hypres.26.141 　

    ISSN： 0916-9636

  560. T+31C polymorphism (M235T) of the angiotensinogen gene and home blood pressure in the Japanese general population: the Ohasama study Peer-reviewed

    M Matsubara, H Metoki, T Katsuya, M Kikuya, M Suzuki, M Michimata, T Araki, A Hozawa, Tsuji, I, T Ogihara, Y Imai

    HYPERTENSION RESEARCH　26　(1)　47-52　2003/01

    DOI： 10.1291/hypres.26.47 　

    ISSN： 0916-9636

  561. Pulse wave velocity and the second derivative of the finger photoplethysmogram in treated hypertensive patients: their relationship and associating factors Peer-reviewed

    J Hashimoto, K Chonan, Y Aoki, T Nishimura, T Ohkubo, A Hozawa, M Suzuki, M Matsubara, M Michimata, T Araki, Y Imai

    JOURNAL OF HYPERTENSION　20　(12)　2415-2422　2002/12

    DOI： 10.1097/01.hjh.0000042887.24999.7b 　

    ISSN： 0263-6352

  562. Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure: the Ohasama study Peer-reviewed

    T Ohkubo, A Hozawa, J Yamaguchi, M Kikuya, K Ohmori, M Michimata, M Matsubara, J Hashimoto, H Hoshi, T Araki, Tsuji, I, H Satoh, S Hisamichi, Y Imai

    JOURNAL OF HYPERTENSION　20　(11)　2183-2189　2002/11

    DOI： 10.1097/00004872-200211000-00017 　

    ISSN： 0263-6352

  563. Alpha-adducin Gly460Trp polymorphism is associated with low renin hypertension in younger subjects in the Ohasama study Peer-reviewed

    K Sugimoto, A Hozawa, T Katsuya, M Matsubara, T Ohkubo, Tsuji, I, M Motone, J Higaki, S Hisamachi, Y Imai, T Ogihara

    JOURNAL OF HYPERTENSION　20　(9)　1779-1784　2002/09

    DOI： 10.1097/00004872-200209000-00022 　

    ISSN： 0263-6352

  564. T+31C polymorphism of angiotensinogen gene and nocturnal blood pressure decline: The Ohasama Study Peer-reviewed

    T Fujiwara, T Katsuya, M Matsubara, T Mikami, K Ishikawa, M Kikuya, T Ohkubo, A Hozawa, M Michimata, M Suzuki, H Metoki, K Asayama, T Araki, Tsuji, I, J Higaki, H Satoh, S Hisamichi, T Ogihara, Y Imai

    AMERICAN JOURNAL OF HYPERTENSION　15　(7)　628-632　2002/07

    DOI： 10.1016/S0895-7061(02)02944-8 　

    ISSN： 0895-7061

  565. Angiotensin-converting enzyme I/D polymorphism and hypertension: The Ohasama study Peer-reviewed

    M Matsubara, M Suzuki, T Fujiwara, M Kikuya, H Metoki, M Michimata, T Araki, Kazama, I, T Satoh, J Hashimoto, A Hozawa, T Ohkubo, Tsuji, I, T Katsuya, J Higaki, T Ogihara, H Satoh, Y Imai

    JOURNAL OF HYPERTENSION　20　(6)　1121-1126　2002/06

    DOI： 10.1097/00004872-200206000-00023 　

    ISSN： 0263-6352

  566. Insufficient duration of action of antihypertensive drugs mediates high blood pressure in the morning in hypertensive population: The Ohasama Study Peer-reviewed

    K Chonan, J Hashimoto, T Ohkubo, Tsuji, I, K Nagai, M Kikuya, A Hozawa, M Matsubara, M Suzuki, T Fujiwara, T Araki, H Satoh, S Hisamichi, Y Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION　24　(4)　261-275　2002/05

    DOI： 10.1081/CEH-120004230 　

    ISSN： 1064-1963

  567. 'Pyridoxine treatment in a subgroup of children with pervasive developmental disorders' Peer-reviewed

    S Kuriyama, M Kamiyama, MD Watanabe, S Tamahashi, Muraguchi, I, T Watanabe, A Hozawa, T Ohkubo, Y Nishino, Y Tsubono, Tsuji, I, S Hisamichi

    DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY　44　(4)　284-286　2002/04

    ISSN： 0012-1622

  568. Association of a mast cell chymase gene variant with HDL cholesterol, but not with blood pressure in the Ohasama study Peer-reviewed

    M Fukuda, T Ohkubo, T Katsuya, A Hozawa, T Asai, M Matsubara, H Kitaoka, Tsuji, I, T Araki, H Satoh, J Higaki, S Hisamichi, Y Imai, T Ogihara

    HYPERTENSION RESEARCH　25　(2)　179-184　2002/03

    DOI： 10.1291/hypres.25.179 　

    ISSN： 0916-9636

  569. Advance in diagnosis of hypertension and cerebrovascular disease. The Ohasama study

    Yutaka Imai, Atsushi Hozawa, Takayoshi Ohkubo, Ichiro Tsuji, Junko Yamaguchi, Michimata Mari, Kikuya Masahiro, Hashimoto Junichiro, Ugajin Takashi, Nishimura Takuya, Aoki Yohei, Satoh Hiroshi

    Brain Hemorrhage　1　19-28　2002

  570. Genetic polymorphisms in the beta-subunit of the epithelial sodium channel (βENaC) gene in the Japanese population Peer-reviewed

    Michiko Suzuki, Tomomi Sato, Tohru Fujiwara, Mari Michimata, Tsutomu Araki, Hirohito Metoki, Masahiro Kikuya, Itsuro Kazama, Junichiro Hashimoto, Atsushi Hozawa, Takayoshi Ohkubo, Ichiro Tsuji, Yutaka Imai, Mitsunobu Matsubara

    Clinical and Experimental Nephrology　6　(3)　130-134　2002

    Publisher: Springer Japan

    DOI： 10.1007/BF03353389 　

    ISSN： 1342-1751

  571. Validation of walking questionnaire for population-based prospective studies in Japan: Comparison with pedometer Peer-reviewed

    Yoshitaka Tsubono, Ichiro Tsuji, Kazuki Fujita, Naoki Nakaya, Atsushi Hozawa, Takayoshi Ohkubo, Aya Kuwahara, Yoko Watanabe, Keiko Ogawa, Yoshikazu Nishino, Shigeru Hisamichi

    Journal of Epidemiology　12　(4)　305-309　2002

    Publisher: Japan Epidemiology Association

    DOI： 10.2188/jea.12.305 　

    ISSN： 1349-9092 0917-5040

  572. Randomized controlled trial of exercise training for older people (Sendai Silver Center Trial; SSCT): 6 months follow up Peer-reviewed

    A Hozawa, Tsuji, I, A Tamagawa, R Nagotomi, N Irie, T Ohkubo, M Saito, K Fujita, A Sato, H Ohmori, S Hisamichi

    JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE　50　(1)　71-72　2001/02

    ISSN： 0039-906X

  573. パーソナリティと白衣効果との関連

    寳澤 篤, 大久保 孝義, 辻 一郎, 久道 茂, 今井 潤, 佐藤 洋, 荒井 由美子, 永井 謙一

    日本公衆衛生学会総会抄録集　58回　429-429　1999/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  574. 家庭血圧の脳卒中発症予測能 随時血圧との比較から

    大久保 孝義, 寳澤 篤, 辻 一郎, 久道 茂, 今井 潤, 佐藤 洋, 永井 謙一

    日本公衆衛生学会総会抄録集　58回　434-434　1999/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  575. パーソナリティと白衣効果との関連

    寳澤 篤, 大久保 孝義, 辻 一郎, 久道 茂, 今井 潤, 佐藤 洋, 荒井 由美子, 永井 謙一

    日本公衆衛生学会総会抄録集　58回　429-429　1999/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  576. 家庭血圧の脳卒中発症予測能 随時血圧との比較から

    大久保 孝義, 寳澤 篤, 辻 一郎, 久道 茂, 今井 潤, 佐藤 洋, 永井 謙一

    日本公衆衛生学会総会抄録集　58回　434-434　1999/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  577. 基本健康診査受診歴と医療費との関連

    西野 善一, 辻 一郎, 桑原 理, 大久保 孝義, 寳澤 篤, 久道 茂, 佐々木 淳

    日本公衆衛生学会総会抄録集　57回　173-173　1998/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  578. 随時血圧と家庭血圧の較差の規定因子は何か

    寳澤 篤, 辻 一郎, 大久保 孝義, 久道 茂, 今井 潤, 佐藤 洋, 永井 謙一

    日本公衆衛生学会総会抄録集　57回　406-406　1998/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  579. 家庭血圧の生命予後予測能 随時血圧との比較から

    大久保 孝義, 辻 一郎, 宝沢 篤, 久道 茂, 今井 潤, 佐藤 洋, 永井 謙一

    日本公衆衛生学会総会抄録集　57回　407-407　1998/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  580. 基本健康診査受診歴と医療費との関連

    西野 善一, 辻 一郎, 桑原 理, 大久保 孝義, 寳澤 篤, 久道 茂, 佐々木 淳

    日本公衆衛生学会総会抄録集　57回　173-173　1998/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  581. 随時血圧と家庭血圧の較差の規定因子は何か

    寳澤 篤, 辻 一郎, 大久保 孝義, 久道 茂, 今井 潤, 佐藤 洋, 永井 謙一

    日本公衆衛生学会総会抄録集　57回　406-406　1998/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  582. 家庭血圧の生命予後予測能 随時血圧との比較から

    大久保 孝義, 辻 一郎, 宝沢 篤, 久道 茂, 今井 潤, 佐藤 洋, 永井 謙一

    日本公衆衛生学会総会抄録集　57回　407-407　1998/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

Show all ︎Show first 5

Misc. 485

  1. 食事における抗酸化力と慢性腎臓病発症との関連 大迫研究

    坪田 恵, 佐藤 倫広, 辰巳 友佳子, 浅山 敬, 菊谷 昌浩, 村上 任尚, 廣瀬 卓男, 目時 弘仁, 寳澤 篤, 大久保 孝義

    日本循環器病予防学会誌　58　(2)　158-158　2023/05

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  2. 東北メディカル・メガバンク計画三世代コホート調査の進捗と今後の計画

    石黒 真美, 小原 拓, 村上 慶子, 上野 史彦, 野田 あおい, 大沼 ともみ, 松崎 芙実子, 目時 弘仁, 菊谷 昌浩, 菅原 準一, 中谷 直樹, 寳澤 篤, 栗山 進一

    Journal of Epidemiology　33　(Suppl.1)　117-117　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  3. 大規模観察研究におけるランダム男女ペア間の循環代謝リスク因子の類似性の検討

    中谷 直樹, 中谷 久美, 土屋 菜歩, 曽根 稔雅, 小暮 真奈, 畑中 里衣子, 菅野 郁美, 目時 弘仁, 小原 拓, 石黒 真美, 寳澤 篤, 栗山 進一

    Journal of Epidemiology　33　(Suppl.1)　173-173　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  4. 家庭血圧に基づく白衣効果の長期再現性 大迫研究

    佐藤 倫広, 吉田 智哉, 目時 弘仁, 村上 任尚, 辰巳 友佳子, 廣瀬 卓男, 高畠 恭介, 坪田 恵, 原 梓, 野村 恭子, 浅山 敬, 菊谷 昌浩, 寳澤 篤, 今井 潤, 大久保 孝義

    Journal of Epidemiology　33　(Suppl.1)　126-126　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  5. Glycemic traits and POAG: Mendelian randomization study in a Japanese population

    羽入田明子, 羽入田明子, 後藤温, 後藤温, 中杤昌弘, 若井建志, 清水厚志, 丹野高三, 木下賢吾, 寶澤篤, 伊藤秀美, 松尾恵太郎, 結城賢弥, 結城賢弥, 坪田一男, 坪田一男, 根岸一乃, 岩崎基

    日本眼科学会雑誌　127　2023

    ISSN： 0029-0203

  6. 正常高値血圧、高値血圧における中心血圧、頸動脈内膜中膜厚と新規高血圧発症の関連

    時岡 紗由理, 中谷 直樹, 中谷 久美, 高瀬 雅仁, 小暮 真奈, 畑中 里衣子, 菅野 郁美, 千葉 一平, 目時 弘仁, 村上 任尚, 佐藤 倫広, 小原 拓, 栗山 進一, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　44回　80-80　2022/10

    Publisher: (NPO)日本高血圧学会

  7. 年齢と骨梁面積率との関連 年齢階級別の検討 ToMMo地域住民コホート調査

    菅野 郁美, 中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 中村 智洋, 小原 拓, 目時 弘仁, 布施 昇男, 栗山 進一, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集　81回　203-203　2022/09

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  8. 心血管・代謝疾患リスク要因における配偶者同士の類似性 2ヵ国バイオバンク横断研究

    中谷 直樹, 土屋 菜歩, 成田 暁, 中村 智洋, 目時 弘仁, 小原 拓, 石黒 真美, 寳澤 篤, 栗山 進一

    日本公衆衛生学会総会抄録集　81回　204-204　2022/09

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  9. 東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の進捗

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 中谷 久美, 千葉 一平, 菅野 郁美, 小原 拓, 中村 智洋, 宇留野 晃, 布施 昇男, 泉 陽子, 丹野 高三, 辻 一郎, 栗山 進一, 寳澤 篤

    東北公衆衛生学会誌　(71)　28-28　2022/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  10. Exploration of BRCA1/2 gene variants in a general population cohort and return of genomic results to the participants

    徳永英樹, 安田純, 島田宗昭, 濱中洋平, 重田昌吾, 布施昇男, 勝岡史城, 荻島創一, 荻島創一, 山口由美, 寳澤篤, 川目裕, 大根田絹子, 青木洋子, 山本雅之, 八重樫伸生

    日本癌学会学術総会抄録集(Web)　81st　2022

  11. メンデルのランダム化法による血中脂質と大腸がんの関係の検討

    岩上 将夫, 後藤 温, 鈴木 詩織, 片桐 諒子, 羽入田 明子, 山地 太樹, 澤田 典絵, 中杤 昌弘, 若井 建志, 須藤 洋一, 清水 厚志, 丹野 高三, 木下 賢吾, 寳澤 篤, 伊藤 秀美, 松尾 恵太郎, 岩崎 基, J-CGEグループ

    Journal of Epidemiology　32　(Suppl.1)　155-155　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  12. メンデルのランダム化法による糖代謝指標と大腸がんの関連解析

    羽入田 明子, 後藤 温, 鈴木 詩織, 片桐 諒子, 岩上 将夫, 山地 太樹, 澤田 典絵, 中杤 昌弘, 若井 建志, 須藤 洋一, 清水 厚志, 丹野 高三, 木下 賢吾, 寳澤 篤, 伊藤 秀美, 松尾 恵太郎, 岩崎 基

    Journal of Epidemiology　32　(Suppl.1)　155-155　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  13. 東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の概要

    中谷 直樹, 小暮 真奈, 畑中 里衣子, 菅野 郁美, 中谷 久美, 小原 拓, 中村 智洋, 宇留野 晃, 布施 昇男, 泉 陽子, 丹野 高三, 辻 一郎, 栗山 進一, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　80回　219-219　2021/11

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  14. 特定健康診査時に尿ナトカリ計で4年連続測定した尿ナトリウム/カリウム比の変化と血圧への影響 COI東北拠点と宮城県登米市の共同研究

    小暮 真奈, 須藤 庸子, 及川 満代, 土屋 菜歩, 平田 匠, 畑中 里衣子, 佐々木 久美子, 黒川 悦子, 宮川 健, 牛田 悠介, 上田 宏幸, 佐々木 秀美, 本間 洋子, 中谷 直樹, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　43回　261-261　2021/10

    Publisher: (NPO)日本高血圧学会

  15. 東日本大震災に伴う災害による健康影響に関する文献レビュー

    高瀬雅仁, 五十嵐有香, 中谷直樹, 小暮真奈, 畑中里衣子, 菅野郁美, 中谷久美, 中村智洋, 後岡広太郎, 後岡広太郎, 寳澤篤

    日本循環器病予防学会誌　56　(3)　2021

    ISSN： 1346-6267

  16. 糖尿病性腎症の発症・進展予測マーカーとしてのフェニル硫酸の有用性

    菊地晃一, 三枝大輔, 金光祥臣, 松本洋太郎, 三瀬広記, 中村智洋, 三島英換, 豊原敬文, 鈴木健弘, 寳澤篤, 和田淳, 富岡佳久, 阿部高明

    日本腎臓学会誌(Web)　62　(4)　2020

    ISSN： 1884-0728

  17. 慢性腎臓病と高血圧の脳卒中発症生涯リスク:大迫研究

    中山晋吾, 佐藤倫広, 目時弘仁, 村上任尚, 浅山敬, 原梓, 廣瀬卓男, 菅野厚博, 井上隆輔, 坪田恵, 菊谷昌浩, 森建文, 寳澤篤, 今井潤, 大久保孝義

    日本腎臓学会誌(Web)　62　(4)　2020

    ISSN： 1884-0728

  18. 新旧(1980-2020年)のライフスタイルからみた国民代表集団大規模コホート研究:NIPPON DATA80/90/2010/2020 2.NIPPON DATA2010実行ワーキンググループ報告

    大久保孝義, 宮本恵宏, 門田文, 有馬久富, 高嶋直敬, 中村幸志, 二宮利治, 秦淳, 寳澤篤, 宮本恵宏, 大澤正樹, 鳥居さゆ希, 東山綾, 久松隆史, 門田文, 浅山敬, 大西浩文, 櫻井勝, 平田匠, 宮澤伊都子, 八谷寛

    新旧(1980-2020年)のライフスタイルからみた国民代表集団大規模コホート研究:NIPPON DATA80/90/2010/2020 令和元年度 総括・分担研究報告書(Web)　2020

  19. 新旧(1980-2020年)のライフスタイルからみた国民代表集団大規模コホート研究:NIPPON DATA80/90/2010/2020 2.日本人における炭水化物・食物繊維摂取と循環器疾患死亡リスクとの関連:NIPPON DATA80の24年追跡結果より

    宮澤伊都子, 三浦克之, 宮川尚子, 近藤慶子, 門田文, 奥田奈賀子, 藤吉朗, 千原泉, 中村好一, 寳澤篤, 中村保幸, 喜多義邦, 由田克士, 岡村智教, 岡山明, 上島弘嗣

    新旧(1980-2020年)のライフスタイルからみた国民代表集団大規模コホート研究:NIPPON DATA80/90/2010/2020 令和元年度 総括・分担研究報告書(Web)　2020

  20. The correlation between birth weight and %FEV1 in people in their 20s; exploring the factors influencing lung function based on Tohoku Medical Megabank Organization community health survey

    大江崇, 山田充啓, 杉浦久敏, 布施昇男, 寳澤篤, 中村智洋, 山本雅之, 一ノ瀬正和

    日本呼吸器学会誌(Web)　9　2020

    ISSN： 2186-5884

  21. 食品摂取回避行動の実態と関連要因の検討:東北メディカル・メガバンク計画地域住民コホート調査

    坪田(宇津木)恵, 丹野高三, 丹野高三, 佐々木亮平, 佐々木亮平, 高梨信之, 事崎由佳, 小暮真奈, 寳澤篤, 坂田清美, 坂田清美

    日本疫学会学術総会講演集(Web)　30th　2020

  22. Reduced sleep efficiency, measured using an objective device, was related to an increased prevalence of home hypertension in Japanese adults. International-journal Peer-reviewed

    Takumi Hirata, Tomohiro Nakamura, Mana Kogure, Naho Tsuchiya, Akira Narita, Ken Miyagawa, Kotaro Nochioka, Akira Uruno, Taku Obara, Naoki Nakaya, Hirohito Metoki, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension　43　(1)　23-29　2020/01

    DOI： 10.1038/s41440-019-0329-0 　

    ISSN： 0916-9636

  23. Multiple measurements of the urinary sodium-to-potassium ratio strongly related home hypertension: TMM Cohort Study. International-journal Peer-reviewed

    Mana Kogure, Takumi Hirata, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Ken Miyagawa, Hiroshi Koshimizu, Taku Obara, Hirohito Metoki, Akira Uruno, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

    Hypertension research : official journal of the Japanese Society of Hypertension　43　(1)　62-71　2020/01

    DOI： 10.1038/s41440-019-0335-2 　

    ISSN： 0916-9636

  24. 家庭での受動喫煙および能動喫煙の組み合わせと高血圧の関連

    平田 匠, 小暮 真奈, 成田 暁, 土屋 菜歩, 中村 智洋, 目時 弘仁, 中谷 直樹, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　78回　223-223　2019/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  25. 配偶者同士の生活習慣の一致性とその年齢の影響 ToMMo 地域住民コホート調査

    中谷 直樹, 土屋 菜歩, 成田 暁, 石黒 真美, 目時 弘仁, 平田 匠, 小暮 真奈, 中村 智洋, 後岡 広太郎, 中谷 久美, 辻 一郎, 呉 繁夫, 栗山 進一, 寳澤 篤

    日本公衆衛生学会総会抄録集　78回　224-224　2019/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  26. 東日本大震災後の仕事の変化によるメンタルヘルスの経年変化 TMM CommCohort Study

    高梨 信之, 丹野 高三, 佐々木 亮平, 事崎 由佳, 三上 貴浩, 寳澤 篤, 坪田 恵, 田鎖 愛理, 大塚 耕太郎, 清水 厚志, 坂田 清美

    日本公衆衛生学会総会抄録集　78回　241-241　2019/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  27. 東日本大震災が沿岸地域の就労と精神的健康に及ぼした影響

    片柳 光昭, 富田 博秋, 瀬戸 萌, 根本 晴美, 奥山 純子, 鈴木 智美, 菅原 由美, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 小高 晃, 辻 一郎, 寳澤 篤

    精神神経学雑誌　(2019特別号)　S753-S753　2019/06

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  28. 腸内細菌由来のフェニル硫酸は糖尿病性腎臓病でのアルブミン尿増悪の原因物質かつ予測マーカーである

    菊地晃一, 三枝大輔, 金光祥臣, 松本洋太郎, 中村智洋, 淺地圭, 三瀬広記, 何欣蓉, 三島英換, 鈴木健弘, 和田淳, 寶澤篤, 伊藤貞嘉, 阿部高明

    日本腎臓学会誌　61　(3)　312-312　2019/05/15

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  29. 一般地域住民における血清クレアチニンによる推定糸球体濾過量(eGFR)の季節差

    良知 弘務, 土屋 菜歩, 平田 匠, 中谷 直樹, 中村 智洋, 成田 暁, 小暮 真奈, 栗山 進一, 菅原 準一, 呉 繁夫, 宮崎 真理子, 寳澤 篤

    日本腎臓学会誌　61　(3)　332-332　2019/05

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  30. 東北メディカル・メガバンク計画 地域住民コホート 進捗と今後の展望

    寳澤 篤, 丹野 高三, 中谷 直樹, 平田 匠, 瀧 靖之, 栗山 進一, 菅原 準一, 坂田 清美, 辻 一郎, 呉 繁夫

    日本老年医学会雑誌　56　(Suppl.)　106-106　2019/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  31. NT-proBNPと慢性腎臓病との関連性 大迫研究

    中山 晋吾, 佐藤 倫宏, 目時 弘仁, 村上 任尚, 浅山 敬, 原 梓, 廣瀬 卓男, 井上 隆輔, 坪田 恵, 宇津木, 菊谷 昌浩, 森 建文, 寳澤 篤, 野出 孝一, 今井 潤, 大久保 孝義

    日本腎臓学会誌　61　(3)　289-289　2019/05

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  32. 白衣高血圧と左室肥大の関連における家庭血圧レベルの影響 大迫研究

    奈良井 大輝, 佐藤 倫広, 村上 任尚, 菊地 ひかり, 中山 晋吾, 高畠 恭介, 廣瀬 卓男, 佐藤 和奏, 浅山 敬, 菊谷 昌浩, 野村 恭子, 寳澤 篤, 目時 弘仁, 今井 潤, 大久保 孝義

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　8回　198-198　2019/05

    Publisher: (NPO)日本高血圧学会

  33. 白衣高血圧と左室肥大の関連における家庭血圧レベルの影響 大迫研究

    奈良井 大輝, 佐藤 倫広, 村上 任尚, 菊地 ひかり, 中山 晋吾, 高畠 恭介, 廣瀬 卓男, 佐藤 和奏, 浅山 敬, 菊谷 昌浩, 野村 恭子, 寳澤 篤, 目時 弘仁, 今井 潤, 大久保 孝義

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　8回　198-198　2019/05

    Publisher: (NPO)日本高血圧学会

  34. NT-proBNPと慢性腎臓病との関連性 大迫研究

    中山 晋吾, 佐藤 倫宏, 目時 弘仁, 村上 任尚, 浅山 敬, 原 梓, 廣瀬 卓男, 井上 隆輔, 坪田 恵, 宇津木, 菊谷 昌浩, 森 建文, 寳澤 篤, 野出 孝一, 今井 潤, 大久保 孝義

    日本腎臓学会誌　61　(3)　289-289　2019/05

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  35. 尿ナトリウム/カリウム比を健診に追加することで高血圧のPAFが12%増加し約50%に:COI東北拠点と登米市の共同研究

    小暮真奈, 小暮真奈, 須藤庸子, 中村智洋, 中村智洋, 土屋菜歩, 土屋菜歩, 平田匠, 平田匠, 成田暁, 成田暁, 宮川健, 宮川健, 中谷直樹, 中谷直樹, 佐々木秀美, 寳澤篤, 寳澤篤

    日本循環器病予防学会誌　54　(2)　122　2019/04/11

    ISSN： 1346-6267

  36. 新規リスク因子(尿ナトカリ比高値・睡眠効率不良)の高血圧への集団寄与危険割合の検討

    平田匠, 平田匠, 中村智洋, 中村智洋, 小暮真奈, 小暮真奈, 宮川健, 小原拓, 小原拓, 中谷直樹, 中谷直樹, 宇留野晃, 宇留野晃, 菅原準一, 菅原準一, 栗山進一, 栗山進一, 寳澤篤, 寳澤篤

    日本循環器病予防学会誌　54　(2)　121　2019/04/11

    ISSN： 1346-6267

  37. 非肥満者において肝機能指標の組み合わせと糖尿病の関連は飲酒により異なるか

    一迫 芙美, 平田 匠, 土屋 菜歩, 中村 智洋, 成田 暁, 小暮 真奈, 中谷 直樹, 栗山 進一, 呉 繁夫, 寳澤 篤

    日本循環器病予防学会誌　54　(2)　115-115　2019/04

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  38. 東北メディカル・メガバンク計画地域住民コホート調査における糖尿病研究

    平田 匠, 寳澤 篤, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 丹野 高三, 佐藤 衛, 菊谷 昌浩, 石垣 泰, 坂田 清美, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫

    糖尿病　62　(Suppl.1)　S-304　2019/04

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

  39. 未治療高血圧者に対する平成29年度特定健康診査時の尿ナトカリ比及び保健指導後の医療受診動向について

    鈴木智美, 鈴木智美, 板橋由紀, 小暮真奈, 堀籠千賀, 中谷直樹, 中村智洋, 土屋菜歩, 平田匠, 成田暁, 渡邊真孝, 小野誠司, 渡辺文昭, 寳澤篤

    宮城県公衆衛生学会会誌　(51)　13　2019/03

    ISSN： 0912-747X

  40. 抗体標識化磁性ビーズを利用する高速・高感度生体分子検出システムの開発

    坂本聡, 加部泰明, 平井美和, 小池一康, 菱木貴子, 松田厚志, 長谷川祐一, 辻田公二, 小野雅之, 峯岸直子, 寳澤篤, 村上善則, 久保充明, 久保充明, 望月勇輔, 河田慎太郎, 内藤靖之, 松田祐子, 北川雄光, 糸長誠, 末松誠, 半田宏

    日本化学会春季年会講演予稿集(CD-ROM)　99th　ROMBUNNO.3F5‐03　2019/03/01

  41. 東北メディカル・メガバンク機構 地域住民コホート調査詳細二次調査

    寳澤 篤, 中谷 直樹, 土屋 菜歩, 中村 智洋, 平田 匠, 成田 暁, 小暮 真奈, 栗山 進一, 菅原 準一, 呉 繁夫

    宮城県公衆衛生学会会誌　(51)　17-17　2019/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  42. 東日本大震災後の岩手県における社会的孤立の変化とその関連要因―地域住民コホート調査―

    事崎由佳, 丹野高三, 佐々木亮平, 高梨信之, 三上貴浩, 寳澤篤, 栗山進一, 辻一郎, 大塚耕太郎, 佐藤衛, 大桃秀樹, 清水厚志, 人見次郎, 坂田清美, 佐々木真理

    日本疫学会学術総会講演集(Web)　29th　122 (WEB ONLY)　2019/01/30

  43. 東日本大震災による家屋損壊程度と過敏性腸症候群の関連

    永家聖, 中谷直樹, 田中由佳里, 金澤素, 荻島創一, 高井貴子, 中村智洋, 土屋菜歩, 平田匠, 成田暁, 小暮真奈, 栗山進一, 田中博, 辻一郎, 呉繁夫, 寳澤篤, 福土審

    日本疫学会学術総会講演集(Web)　29th　149 (WEB ONLY)　2019/01/30

  44. 配偶者の主観的健康観と自身の抑うつ症状との関連:東北メディカル・メガバンク計画・地域住民コホート調査

    中谷直樹, 土屋菜歩, 中谷久美, 成田暁, 平田匠, 中村智洋, 小暮真奈, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web)　29th　122 (WEB ONLY)　2019/01/30

  45. 非肥満者における肝機能指標の組み合わせと糖尿病の関連

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    日本疫学会学術総会講演集(Web)　29th　151 (WEB ONLY)　2019/01/30

  46. 夫婦間のメタボリック症候群及び構成因子の共有度:東北メディカル・メガバンク計画―地域住民コホート調査

    土屋菜歩, 橋本航, 中谷直樹, 中村智洋, 平田匠, 成田暁, 小暮真奈, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web)　29th　154 (WEB ONLY)　2019/01/30

  47. 遺伝因子と飲酒量の交互作用と随時血圧値の関連―東北メディカル・メガバンク計画地域住民コホート調査―

    成田暁, 中谷直樹, 小暮真奈, 田宮元, 中村智洋, 土屋菜歩, 平田匠, 丹野高三, 坂田清美, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web)　29th　147 (WEB ONLY)　2019/01/30

  48. Household Salt Intake Level is Associated With All-Cause, Cardiovascular and Stroke Mortality: A 24-Year Follow-Up of Nippon Data80

    Azusa Shima, Naomi Miyamatsu, Katsuyuki Miura, Naoko Miyagawa, Nagako Okuda, Nobuo Nishi, Katsushi Yoshita, Aya Kadota, Harumitsu Suzuki, Keiko Kondo, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima

    CIRCULATION　139　2019

    DOI： 10.1161/circ.139.suppl_1.P400 　

    ISSN： 0009-7322

    eISSN： 1524-4539

  49. 新旧(1980-2020年)のライフスタイルからみた国民代表集団大規模コホート研究:NIPPON DATA80/90/2010/2020 NIPPON DATA2010実行ワーキンググループ報告

    大久保孝義, 宮本恵宏, 門田文, 清原裕, 寳澤篤, 二宮利治, 有馬久富, 中村幸志, 高嶋直敬, 大澤正樹, 東山綾, 久松隆史, 鳥居さゆ希, 八谷寛, 大西浩文, 櫻井勝, 浅山敬, 平田匠, 宮澤伊都子

    新旧(1980-2020年)のライフスタイルからみた国民代表集団大規模コホート研究:NIPPON DATA80/90/2010/2020 平成30年度 総括・分担研究報告書(Web)　2019

  50. 東日本大震災後の社会的孤立と抑うつ症状との関連 TMM CommCohort Study

    事崎 由佳, 丹野 高三, 佐々木 亮平, 高梨 信之, 三上 貴浩, 寳澤 篤, 栗山 進一, 辻 一郎, 高橋 宗康, 清水 厚志, 人見 次郎, 坂田 清美

    日本公衆衛生学会総会抄録集　77回　463-463　2018/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  51. 東日本大震災後の心理的苦痛有病割合の推移 地域住民コホート調査

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    日本公衆衛生学会総会抄録集　77回　506-506　2018/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  52. 東日本大震災の被災地住民における平均歩数の変化 地域住民コホート調査

    中谷 直樹, 中村 智洋, 土屋 菜歩, 平田 匠, 成田 暁, 小暮 真奈, 後岡 広太郎, 丹野 高三, 坂田 清美, 小原 拓, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　77回　209-209　2018/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  53. 尿中ナトリウムカリウム比値と家庭血圧値の変化 地域住民コホート調査

    小暮 真奈, 中谷 直樹, 土屋 菜歩, 中村 智洋, 平田 匠, 成田 暁, 後岡 広太郎, 丹野 高三, 坂田 清美, 小原 拓, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　77回　215-215　2018/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  54. 東日本大震災の被災地住民における家庭血圧値の変化 地域住民コホート調査

    中村 智洋, 中谷 直樹, 土屋 菜歩, 平田 匠, 成田 暁, 小暮 真奈, 後岡 広太郎, 丹野 高三, 坂田 清美, 小原 拓, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　77回　218-218　2018/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  55. 東日本大震災後のメンタルヘルス関連指標変化と家屋被害の関連

    土屋 菜歩, 中村 智洋, 平田 匠, 成田 暁, 小暮 真奈, 丹野 高三, 坂田 清美, 小原 拓, 中谷 直樹, 栗山 進一, 辻 一郎, 呉 繁夫, 大塚 耕太郎, 富田 博秋, 寳澤 篤

    日本公衆衛生学会総会抄録集　77回　252-252　2018/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  56. 家屋損壊程度と骨梁面積率の変化量の関連 東北メディカル・メガバンク事業

    成田 暁, 中谷 直樹, 中村 智洋, 土屋 菜歩, 平田 匠, 小暮 真奈, 後岡 広太郎, 丹野 高三, 坂田 清美, 小原 拓, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　77回　253-253　2018/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  57. 家屋の損壊の程度と頸動脈エコー内膜中膜肥厚の変化 地域住民コホート調査

    寳澤 篤, 中谷 久美, 平田 匠, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 後岡 広太郎, 丹野 高三, 坂田 清美, 小原 拓, 中谷 直樹, 栗山 進一, 辻 一郎, 呉 繁夫

    日本公衆衛生学会総会抄録集　77回　345-345　2018/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  58. 一般住民における尿Na/K比と腎機能障害への進行の関連 住民コホート調査

    良知 弘務, 土屋 菜歩, 平田 匠, 中谷 直樹, 中村 智洋, 成田 暁, 小暮 真奈, 小原 拓, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　77回　345-345　2018/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  59. 東日本大震災に伴う家屋被害の程度とHbA1c値の変化の関連 地域住民コホート調査

    平田 匠, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 後岡 広太郎, 丹野 高三, 坂田 清美, 小原 拓, 中谷 直樹, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　77回　358-358　2018/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  60. 一般住民における尿中蛋白排泄量に関連するSNPの探索

    奥田 拓史, 牧野 悟士, 田邊 修, 石井 正, 伊藤 貞嘉, 寳澤 篤, 丹野 高三, 佐々木 真理, 田宮 元, 山本 雅之, 阿部 倫明

    日本高血圧学会総会プログラム・抄録集　41回　OE02-05　2018/09

    Publisher: (NPO)日本高血圧学会

  61. 単日および複数日測定による尿ナトカリ比値と高血圧有病率との関連 東北メディカル・メガバンク計画コホート調査の成果から

    小暮 真奈, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 宮川 健, 栗山 進一, 菅原 準一, 菊谷 昌浩, 寳澤 篤

    日本循環器病予防学会誌　53　(2)　181-181　2018/05

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  62. 頸動脈IMTの男女差はそのリスクファクターの集積数の分布で一部説明できる

    木皿 楓子, 高井 貴子, 菊谷 昌浩, 目時 弘仁, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本循環器病予防学会誌　53　(2)　183-183　2018/05

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  63. 東北大学と自治体における尿ナトカリ計の社会実装についての続報

    小暮 真奈, 寳澤 篤

    宮城県公衆衛生学会会誌　(50)　12-15　2018/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  64. 特定保健指導前後のナトリウムカリウム比変化と家庭血圧値変化との関連 東北大学COI拠点と七ヶ浜町の共同研究

    小暮 真奈, 宮川 健, 板橋 由紀, 鈴木 智美, 土屋 菜歩, 中村 智洋, 中谷 直樹, 青木 ゆかり, 阿部 真也, 安田 純, 寳澤 篤

    宮城県公衆衛生学会会誌　(50)　20-20　2018/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  65. 東北メディカル・メガバンク地域住民コホート調査に基づく、日本人呼気一酸化窒素濃度の分布と影響因子の解析(中間報告)

    山田 充啓, 杉浦 久敏, 布施 昇男, 寳澤 篤, 高井 貴子, 土屋 奈歩, 光根 歩, 栗山 進一, 山本 雅之, 一ノ瀬 正和

    日本呼吸器学会誌　7　(増刊)　213-213　2018/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

  66. サンプル間の非独立性が関連解析に及ぼす影響の予備的検討

    成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 田宮元, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web)　28th　134 (WEB ONLY)　2018/02/01

  67. 東日本大震災後の夫婦における生活習慣の共有度についての検討

    土屋菜歩, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web)　28th　77 (WEB ONLY)　2018/02/01

  68. 日本茶摂取頻度と頸動脈内膜中膜肥厚の関連

    寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 木皿楓子, 丹野高三, 菊谷昌浩, 高井貴子, 菅原準一, 栗山進一, 辻一郎, 呉繁夫

    日本疫学会学術総会講演集(Web)　28th　116 (WEB ONLY)　2018/02/01

  69. 東日本大震災の被災者における高い平均歩数と関連する要因:地域住民コホート調査

    中谷直樹, 成田暁, 土屋菜歩, 中村智洋, 小暮真奈, 丹野高三, 坂田清美, 菊谷昌弘, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web)　28th　137 (WEB ONLY)　2018/02/01

  70. 周辺環境へのアクセシビリティと産後6ヶ月時点の抑うつ症状との関連:三世代コホート調査

    永井雅人, 水野聖士, 小暮真奈, 石黒真美, 山中千鶴, 松原博子, 小原拓, 小原拓, 菊谷昌浩, 目時弘仁, 目時弘仁, 辻一郎, 呉繁夫, 寳澤篤, 栗山進一, 栗山進一

    日本疫学会学術総会講演集(Web)　28th　85 (WEB ONLY)　2018/02/01

  71. 東日本大震災による家屋損壊の程度とメタボリック症候群の構成要素

    中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web)　28th　137 (WEB ONLY)　2018/02/01

  72. 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 イベント判定委員会報告(ND2010イベント判定委員会)

    大久保孝義, 門田文, 清原裕, 寳澤篤, 二宮利治, 有馬久富, 中村幸志, 高嶋直敬, 宮本恵宏, 大澤正樹, 東山綾, 長澤晋哉, 久松隆史, 鳥居さゆ希, 門田文, 八谷寛, 大西浩文, 櫻井勝, 浅山敬, 平田匠, 宮澤伊都子

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成29年度 総括・分担研究報告書(Web)　2018

  73. 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 国民健康保険受給者における健診受診の関連要因―NIPPON DATA2010横断解析―

    今村晴彦, 小暮真奈, 喜多義邦, 中川秀昭, 寳澤篤, 岡村智教, 村上義孝, 西信雄, 奥田奈賀子, 門田文, 大久保孝義, 上島弘嗣, 岡山明, 三浦克之

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成29年度 総括・分担研究報告書(Web)　87‐88 (WEB ONLY)　2018

  74. Association between mild physical injury and psychological distress: Shichigahama Health Promotion Project

    NARITA Akira, NAKAYA Naoki, NAKAMURA Tomohiro, TSUCHIYA Naho, KOGURE Mana, TSUJI Ichiro, HOZAWA Atsushi, TOMITA Hiroaki

    Nihon Koshu Eisei Zasshi(JAPANESE JOURNAL OF PUBLIC HEALTH)　65　(4)　157-163　2018

    Publisher: Japanese Society of Public Health

    DOI： 10.11236/jph.65.4_157 　

    ISSN： 0546-1766

  75. 東北メディカル・メガバンク機構が実施したコホート調査の歯科健診

    小山 史穂子, 相田 潤, 川嶋 順子, 松井 裕之, 高井 貴子, 小坂 健, 栗山 進一, 寳澤 篤, 坪井 明人

    日本公衆衛生学会総会抄録集　76回　569-569　2017/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  76. 日本人高齢者の貧血に関連する社会的要因 NIPPON DATA2010

    新杉 知沙, 西 信雄, 門田 文, 寳澤 篤, 大久保 孝義, 奥田 奈賀子, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之, NIPPON DATA, 研究グループ

    日本公衆衛生学会総会抄録集　76回　335-335　2017/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  77. 東北メディカル・メガバンク計画地域住民コホート調査における参加者のAQについて

    山中 千鶴, 中谷 直樹, 成田 暁, 中村 智洋, 土屋 菜歩, 小暮 真奈, 菊谷 昌浩, 石黒 真美, 菅原 準一, 辻 一郎, 呉 繁夫, 寳澤 篤, 栗山 進一

    日本公衆衛生学会総会抄録集　76回　285-285　2017/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  78. 東北メディカル・メガバンク計画における地域住民コホート調査の詳細二次調査の概要

    寳澤 篤, 丹野 高三, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 菊谷 昌浩, 目時 弘仁, 坂田 清美, 菅原 準一, 栗山 進一, 辻 一郎, 中村 元行, 呉 繁夫

    日本公衆衛生学会総会抄録集　76回　287-287　2017/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  79. 東日本大震災後の地域住民における腎機能と関連因子

    土屋 菜歩, 清元 秀泰, 中谷 直樹, 中村 智洋, 成田 暁, 小暮 真奈, 菊谷 昌浩, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　76回　290-290　2017/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  80. 尿中ナトリウムカリウム比と高血圧有病リスクとの関連 地域住民コホート調査

    小暮 真奈, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 清元 秀泰, 菊谷 昌浩, 目時 弘仁, 小原 拓, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　76回　291-291　2017/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  81. 東日本大震災後の家屋損壊程度と体脂肪率の関連 地域住民コホート調査

    中村 智洋, 中谷 直樹, 土屋 菜歩, 成田 暁, 小暮 真奈, 丹野 高三, 佐々木 亮平, 坂田 清美, 菊谷 昌浩, 高井 貴子, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　76回　292-292　2017/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  82. 地域住民コホート調査における年齢別の中心血圧分布

    菊谷 昌浩, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 目時 弘仁, 小原 拓, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　76回　293-293　2017/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  83. 頸動脈IMTとリスク因子の関連 東北メディカル・メガバンク計画地域住民コホート調査

    木皿 楓子, 土屋 菜歩, 中谷 直樹, 中村 智洋, 成田 暁, 小暮 真奈, 高井 貴子, 菊谷 昌浩, 目時 弘仁, 丹野 高三, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　76回　293-293　2017/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  84. 性・年齢階級別にみた家族との同居状況と心理的苦痛の関連 地域住民コホート調査

    及川 真紀, 佐藤 喜根子, 佐藤 眞理, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 丹野 高三, 富田 博秋, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　76回　315-315　2017/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  85. 地域住民コホート調査における家屋の被害の程度と平均歩数の関連

    中谷 直樹, 成田 暁, 中村 智洋, 土屋 菜歩, 小暮 真奈, 丹野 高三, 坂田 清美, 菊谷 昌浩, 高井 貴子, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　76回　325-325　2017/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  86. 被災地域では仮設だけでなくみなし仮設居住者も食事摂取不良のリスクとなる

    坪田 恵, 高梨 信之, 佐々木 亮平, 丹野 高三, 寳澤 篤, 栗山 進一, 辻 一郎, 坂田 清美

    日本公衆衛生学会総会抄録集　76回　325-325　2017/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  87. 日本人高齢者の貧血に関連する社会的要因 NIPPON DATA2010

    新杉 知沙, 西 信雄, 門田 文, 寳澤 篤, 大久保 孝義, 奥田 奈賀子, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之, NIPPON DATA, 研究グループ

    日本公衆衛生学会総会抄録集　76回　335-335　2017/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  88. 東北メディカル・メガバンクにおける過敏性腸症候群の有病割合 地域住民コホート調査

    永家 聖, 中谷 直樹, 田中 由佳里, 金澤 素, 荻島 創一, 高井 貴子, 中村 智洋, 土屋 菜歩, 成田 暁, 栗山 進一, 田中 博, 辻 一郎, 呉 繁夫, 寳澤 篤, 福土 審

    日本公衆衛生学会総会抄録集　76回　395-395　2017/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  89. 東日本大震災による家屋の被災状況と骨密度の関連 東北メディカル・メガバンク事業

    成田 暁, 中谷 直樹, 中村 智洋, 土屋 菜歩, 小暮 真奈, 丹野 高三, 坂田 清美, 菊谷 昌浩, 高井 貴子, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　76回　409-409　2017/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  90. 東北メディカル・メガバンク機構が実施したコホート調査の歯科健診

    小山 史穂子, 相田 潤, 川嶋 順子, 松井 裕之, 高井 貴子, 小坂 健, 栗山 進一, 寳澤 篤, 坪井 明人

    日本公衆衛生学会総会抄録集　76回　569-569　2017/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  91. 東日本大震災被災地における運動習慣の状況 TMM CommCohort Study

    高梨 信之, 丹野 高三, 佐々木 亮平, 坪田 恵, 坂田 清美, 寳澤 篤, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 栗山 進一, 辻 一郎, 中村 元行, 人見 次郎

    日本公衆衛生学会総会抄録集　76回　603-603　2017/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  92. 東日本大震災被災地における社会的孤立の状況 TMM CommCohort Study

    佐々木 亮平, 丹野 高三, 高梨 信之, 坪田 恵, 宇津木, 坂田 清美, 寳澤 篤, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 栗山 進一, 辻 一郎, 中村 元行, 人見 次郎

    日本公衆衛生学会総会抄録集　76回　603-603　2017/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  93. 東北メディカル・メガバンク計画地域住民コホート調査における参加者の筋力について

    永井 雅人, 土屋 菜歩, 菊谷 昌浩, 中谷 直樹, 成田 暁, 中村 智洋, 小暮 真奈, 丹野 高三, 坂田 清美, 菅原 準一, 辻 一郎, 呉 繁夫, 栗山 進一, 寳澤 篤

    日本公衆衛生学会総会抄録集　76回　652-652　2017/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  94. 東北メディカル・メガバンク計画 高血圧に関する疫学研究について

    寳澤 篤

    日本高血圧学会総会プログラム・抄録集　40回　240-240　2017/10

    Publisher: (NPO)日本高血圧学会

  95. 東日本大震災後の被災地における降圧治療中患者の血圧管理 東北メディカル・メガバンク地域住民コホート調査

    小原 拓, 菊谷 昌浩, 石黒 真美, 目時 弘仁, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　40回　407-407　2017/10

    Publisher: (NPO)日本高血圧学会

  96. 厳密な安静後の診察室血圧値と家庭血圧値の比較、及びその差に影響を及ぼす要因の検討 滋賀動脈硬化疫学研究(SESSA)

    門脇 紗也佳, 寳澤 篤, 藤吉 朗, 久松 隆史, 佐藤 敦, 田中 佐智子, 岡村 智教, 大久保 孝義, 三浦 克之, 上島 弘嗣

    日本高血圧学会総会プログラム・抄録集　40回　408-408　2017/10

    Publisher: (NPO)日本高血圧学会

  97. 検診時血圧と家庭血圧の男女別年齢階級別平均値 東北メディカル・メガバンク計画地域住民コホート調査

    目時 弘仁, 佐藤 倫広, 村上 任尚, 石黒 真美, 小原 拓, 菊谷 昌浩, 清元 秀泰, 寳澤 篤

    日本高血圧学会総会プログラム・抄録集　40回　411-411　2017/10

    Publisher: (NPO)日本高血圧学会

  98. 母体出生体重と妊娠高血圧症候群の関連 三世代コホート調査での検討

    和形 麻衣子, 土屋 菜歩, 中谷 直樹, 目時 弘仁, 寳澤 篤, 栗山 進一, 八重樫 伸生, 菅原 準一

    日本妊娠高血圧学会雑誌　24　58-58　2017/09

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

  99. 飲酒量と推定食塩摂取量との関連:東北メディカル・メガバンク計画地域住民コホート調査

    小暮真奈, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 坪田(宇津木, 恵, 丹野高三, 寳澤篤

    日本アルコール・薬物医学会雑誌　52　(4)　204　2017/08

    ISSN： 1341-8963

  100. 東日本大震災被災コミュニティの就労状況と精神的健康に関する縦断的研究

    片柳 光昭, 瀬戸 萌, 根本 晴美, 菅原 由美, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小高 晃, 辻 一郎, 寳澤 篤, 富田 博秋

    日本社会精神医学会雑誌　26　(3)　240-241　2017/08

    Publisher: (一社)日本社会精神医学会

    ISSN： 0919-1372

  101. 生活習慣からアディクションを考える 良いアディクションor悪いアディクション 問題提起 ポピュレーションストラテジーから生活習慣全体を考える

    寳澤 篤

    日本アルコール・薬物医学会雑誌　52　(4)　112-112　2017/08

    Publisher: 日本アルコール・アディクション医学会

    ISSN： 1341-8963

  102. 尿ナトカリ計を特定健康診査・特定保健指導に活用した自治体の新たな試み

    小暮 真奈, 宮川 健, 土屋 菜歩, 中村 智洋, 中谷 直樹, 安田 純, 寳澤 篤

    東北公衆衛生学会誌　(66)　21-21　2017/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  103. 性・年齢階級別にみた東日本大震災後の平均歩数 地域住民コホート調査

    中谷 直樹, 成田 暁, 中村 智洋, 土屋 菜歩, 小暮 真奈, 丹野 高三, 坂田 清美, 菊谷 昌浩, 高井 貴子, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    東北公衆衛生学会誌　(66)　29-29　2017/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  104. 性・年齢別に見た東日本大震災後の地域住民における腎機能と頸動脈内膜中膜複合体厚の関連

    土屋 菜歩, 中谷 直樹, 中村 智洋, 成田 暁, 小暮 真奈, 菊谷 昌浩, 丹野 高三, 菅原 準一, 清元 秀泰, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    東北公衆衛生学会誌　(66)　30-30　2017/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  105. 移民に対するHIV対策 系統的レビュー

    木皿 楓子, 土屋 菜歩, 寳澤 篤

    東北公衆衛生学会誌　(66)　41-41　2017/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  106. Genome-wide association study identifies novel susceptibility loci for tanning ability in Japanese population

    K. Shido, K. Kojima, A. Hozawa, S. Ogishima, N. Minegishi, Y. Kawai, G. Tamiya, K. Tanno, K. Yamasaki, S. Aiba, Y. Suzuki, M. Nagasaki

    JOURNAL OF INVESTIGATIVE DERMATOLOGY　137　(5)　S86-S86　2017/05

    ISSN： 0022-202X

    eISSN： 1523-1747

  107. 生活習慣病の予防・改善の取り組みと社会的要因の関連 NIPPON DATA 2010

    五領田 小百合, 西 信雄, 寳澤 篤, 由田 克士, 荒井 裕介, 近藤 慶子, 宮川 尚子, 早川 岳人, 藤吉 朗, 門田 文, 大久保 孝義, 岡村 智教, 奥田 奈賀子, 上島 弘嗣, 岡山 明, 三浦 克之

    日本循環器病予防学会誌　52　(2)　212-212　2017/05

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  108. Reverse Causality of the Relationship Between Dietary Cholesterol and Serum Low Density Lipoprotein Cholesterol Associated With Education and Employment: the INTERLIPID Study

    Yukiko Okami, Hirotsugu Ueshima, Yasuyuki Nakamura, Nagako Okuda, Hideaki Nakagawa, Kiyomi Sakata, Shigeyuki Saitoh, Akira Okayama, Katsushi Yoshita, Naoko Miyagawa, Sohel R. Choudhury, Queenie Chan, Paul Elliott, Jeremiah Stamler, Katsuyuki Miura

    CIRCULATION　135　2017/03

    ISSN： 0009-7322

    eISSN： 1524-4539

  109. Lifestyle Factors Related to the Difference in Serum Lipids Between Japanese -Americans in Hawaii and Japanese in Japan: the INTERLIPID Study

    Cecilia Kimani, Aya Kadota, Katsuyuki Miura, Naoko Miyagawa, Nagako Okuda, Katsushi Yoshita, Masaru Sakurai, Akira Okayama, Hideaki Nakagawa, Shigeyuki Saitoh, Kiyomi Sakata, Beatriz Rodriguez, Kamal Masaki, Queenie Chan, Paul Elliott, Jeremiah Stamler, Hirotsugu Ueshima

    CIRCULATION　135　2017/03

    ISSN： 0009-7322

    eISSN： 1524-4539

  110. 東北大学と七ヶ浜町における特定保健指導に対するNa/K計社会実装の試みについて

    寳澤 篤

    宮城県公衆衛生学会会誌　(49)　6-9　2017/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  111. 東日本大震災後の宮城県における小中学生の気管支喘息と湿疹の有症率について 東北大学東北メディカル・メガバンク機構地域子ども長期健康調査より

    宮下 真子, 菊谷 昌浩, 田中 彰二, 山中 千鶴, 佐藤 ゆき, 水野 聖士, 石黒 真美, 小原 拓, 目時 弘仁, 成田 暁, 土屋 菜歩, 中村 智洋, 中谷 直樹, 寳澤 篤, 辻 一郎, 栗山 進一

    宮城県公衆衛生学会会誌　(49)　14-14　2017/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  112. 東北メディカル・メガバンク事業 地域住民コホート(宮城県)の進捗とこれまでの成果で見えてきたこと

    寳澤 篤, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 菊谷 昌浩, 小原 拓, 石黒 真美, 佐藤 ゆき, 山中 千鶴, 宮下 真子, 目時 弘仁, 栗山 進一, 辻 一郎

    宮城県公衆衛生学会会誌　(49)　17-17　2017/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  113. 自宅から最寄駅までの距離とBody Mass Indexの関連 震災後の住居による層別化解析

    土屋 菜歩, 中谷 直樹, 中村 智洋, 成田 暁, 小暮 真奈, 栗山 進一, 菅原 準一, 呉 繁夫, 辻 一郎, 寳澤 篤

    宮城県公衆衛生学会会誌　(49)　18-18　2017/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  114. メタボリックシンドローム第2位からの脱却を目指して 部門横断的な取り組みの必要性 一昨年の県民健康調査の結果報告+身体活動についてのポピュレーション・ストラテジーについて

    寳澤 篤

    宮城県公衆衛生学会会誌　(49)　24-25　2017/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  115. 一般集団におけるcystatin Cベースの推定GFRと心血管疾患バイオマーカーとの間の関連性 東北メディカル・メガバンクプロジェクト(Relationship between Cystatin C-based Estimated GFR and Biomarkers of Cardiovascular Disease in a General Population: The Tohoku Medical Megabank Project)

    大崎 拓也, 佐藤 衛, 高橋 祐司, 丹野 高三, 那須 崇人, 坂田 清美, 中村 元行, 森野 禎浩, 寳澤 篤, 清元 秀泰

    日本循環器学会学術集会抄録集　81回　OJ-072　2017/03

    Publisher: (一社)日本循環器学会

  116. 国民健康保険受給者における健診受診の関連要因―NIPPON DATA2010横断解析―

    今村晴彦, 小暮真奈, 喜多義邦, 中川秀昭, 寳澤篤, 岡村智教, 村上義孝, 西信雄, 奥田奈賀子, 門田文, 大久保孝義, 上島弘嗣, 岡山明, 三浦克之

    日本疫学会学術総会講演集(Web)　27th　94 (WEB ONLY)　2017/01/25

  117. 東日本大震災後の沿岸部と内陸部の慢性疾患の治療中断割合の比較

    中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 富田博秋, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web)　27th　100 (WEB ONLY)　2017/01/25

  118. 東日本大震災後の宮城県におけるメタボリック症候群の規定要因:地域住民コホート

    中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web)　27th　103 (WEB ONLY)　2017/01/25

  119. 東日本大震災後における自宅から最寄駅までの距離とBMIの関連は食事パターンで説明できるか

    小暮真奈, 成田暁, 土屋菜歩, 中村智洋, 中谷直樹, 丹野高三, 坂田清美, 島津太一, 菊谷昌浩, 菅原準一, 栗山進一, 呉繁夫, 辻一郎, 寳澤篤

    日本疫学会学術総会講演集(Web)　27th　88 (WEB ONLY)　2017/01/25

  120. 東北メディカル・メガバンク事業―地域住民コホート調査の進捗―

    寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 菊谷昌浩, 菅原準一, 鈴木洋一, 佐藤衛, 峯岸直子, 栗山進一, 辻一郎, 中村元行, 呉繁夫

    日本疫学会学術総会講演集(Web)　27th　113 (WEB ONLY)　2017/01/25

  121. 東日本大震災後のメンタルヘルスの内陸‐沿岸較差:東北メディカル・メガバンク事業

    成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 冨田博秋, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    日本疫学会学術総会講演集(Web)　27th　126 (WEB ONLY)　2017/01/25

  122. 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 国民健康保険受給者における健診受診の関連要因―NIPPON DATA2010横断解析―

    今村晴彦, 小暮真奈, 喜多義邦, 中川秀昭, 寳澤篤, 岡村智教, 村上義孝, 西信雄, 奥田奈賀子, 門田文, 大久保孝義, 上島弘嗣, 岡山明, 三浦克之

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成28年度 総括・分担研究報告書(Web)　70‐72 (WEB ONLY)　2017

  123. 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 社会的要因と食習慣に関する態度の関連:NIPPON DATA2010

    五領田小百合, 西信雄, 寳澤篤, 由田克士, 荒井裕介, 近藤慶子, 宮川尚子, 早川岳人, 藤吉朗, 門田文, 大久保孝義, 岡村智教, 奥田奈賀子, 上島弘嗣, 岡山明, 三浦克之

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成28年度 総括・分担研究報告書(Web)　64‐65 (WEB ONLY)　2017

  124. 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 NIPPON DATA2010イベント判定委員会

    大久保孝義, 門田文, 清原裕, 寳澤篤, 二宮利治, 中村幸志, 高嶋直敬, 宮本恵宏, 大澤正樹, 東山綾, 長澤晋哉, 久松隆史, 鳥居さゆ希, 八谷寛, 大西浩文, 櫻井勝, 浅山敬, 平田匠, 宮澤伊都子

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成28年度 総括・分担研究報告書(Web)　21‐24 (WEB ONLY)　2017

  125. 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 飲酒と高血圧との関連はフラッシング反応により修飾されるか:NIPPON DATA2010

    小暮真奈, 土屋菜歩, 寳澤篤, 中谷直樹, 中村智洋, 宮松直美, 田中英夫, 若林一郎, 東山綾, 奥田奈賀子, 高嶋直敬, 藤吉朗, 門田文, 大久保孝義, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成28年度 総括・分担研究報告書(Web)　49‐50 (WEB ONLY)　2017

  126. 東北メディカル・メガバンク事業 地域住民コホート調査の詳細とドルーゼン解析調査

    本間 慶, 布施 昇男, 高井 貴子, 清元 秀泰, 菅原 純一, 鈴木 洋一, 菊谷 昌浩, 栗山 進一, 寳澤 篤, 八重樫 伸生, 呉 繁夫, 山本 雅之

    眼科臨床紀要　9　(11)　926-926　2016/11

    Publisher: 眼科臨床紀要会

    ISSN： 1882-5176

  127. 東日本大震災における外傷と心理的苦痛の関連 七ヶ浜健康増進プロジェクト

    成田 暁, 中谷 直樹, 中村 智洋, 土屋 菜歩, 小暮 真奈, 辻 一郎, 寳澤 篤, 富田 博秋

    日本公衆衛生学会総会抄録集　75回　208-208　2016/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  128. 東日本大震災後の自宅から最寄駅までの距離と高血圧治療中断に関する地理疫学的検討

    土屋 菜歩, 中谷 直樹, 中村 智洋, 成田 暁, 小暮 真奈, 丹野 高三, 佐々木 亮平, 坂田 清美, 菊谷 昌浩, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　75回　253-253　2016/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  129. 東日本大震災後の身体活動量とこころの健康の関連 地域住民コホート調査

    中村 智洋, 中谷 直樹, 土屋 菜歩, 成田 暁, 小暮 真奈, 丹野 高三, 佐々木 亮平, 坂田 清美, 富田 博秋, 菊谷 昌浩, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　75回　288-288　2016/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  130. 沿岸部居住者における東日本大震災後の新規うつ病・PTSD罹患リスク

    中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 丹野 高三, 佐々木 亮平, 坂田 清美, 富田 博秋, 菊谷 昌浩, 菅原 準一, 栗山 進一, 辻 一郎, 呉 繁夫, 寳澤 篤

    日本公衆衛生学会総会抄録集　75回　303-303　2016/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  131. 東日本大震災後の現在の居住地と食事パターンの関連 地域住民コホート調査

    小暮 真奈, 成田 暁, 土屋 菜歩, 中村 智洋, 中谷 直樹, 丹野 高三, 坂田 清美, 島津 太一, 菊谷 昌浩, 菅原 準一, 栗山 進一, 呉 繁夫, 辻 一郎, 寳澤 篤

    日本公衆衛生学会総会抄録集　75回　304-304　2016/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  132. 東北メディカル・メガバンク事業 地域住民コホート調査の進捗について

    寳澤 篤, 丹野 高三, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 佐々木 亮平, 高梨 信之, 坂田 清美, 菅原 準一, 栗山 進一, 中村 元行, 呉 繁夫, 辻 一郎

    日本公衆衛生学会総会抄録集　75回　381-381　2016/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  133. 検体採取のタイミングによる随時尿中Na/K比の検討 TMM CommCohort Study

    丹野 高三, 佐々木 亮平, 高梨 信之, 坂田 清美, 寳澤 篤, 栗山 進一, 辻 一郎, 中村 元行, 人見 次郎

    日本公衆衛生学会総会抄録集　75回　424-424　2016/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  134. 東日本大震災被災状況とうつ病及びPTSD罹患リスクとの関連

    高梨 信之, 丹野 高三, 佐々木 亮平, 大塚 耕太郎, 坂田 清美, 中谷 直樹, 寳澤 篤, 栗山 進一, 辻 一郎, 中村 元行, 人見 次郎

    日本公衆衛生学会総会抄録集　75回　579-579　2016/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  135. 東日本大震災被災地住民の健康知識に関連する要因の検討

    佐々木 亮平, 丹野 高三, 中谷 直樹, 寳澤 篤, 高梨 信之, 坂田 清美, 清水 厚志

    日本公衆衛生学会総会抄録集　75回　581-581　2016/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  136. 震災1年後の将来の住宅の見通しと心理的苦痛リスク

    中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 辻 一郎, 寳澤 篤, 富田 博秋

    東北公衆衛生学会誌　(65)　14-14　2016/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  137. 自宅から最寄駅までの距離と歩行習慣及びBody Mass Indexの関連 東北メディカル・メガバンク事業 地域住民コホート調査

    土屋 菜歩, 中谷 直樹, 中村 智洋, 成田 暁, 清元 秀泰, 栗山 進一, 呉 繁夫, 辻 一郎, 寳澤 篤

    日本循環器病予防学会誌　51　(2)　124-124　2016/05

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  138. 東日本大震災1年後の沿岸部被災地における心理的苦痛と高血圧治療中断の関連 七ヶ浜健康増進プロジェクト

    中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 辻 一郎, 寳澤 篤, 富田 博秋

    日本循環器病予防学会誌　51　(2)　134-134　2016/05

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  139. 尿検査が特定健診における血圧有所見者の受診行動に与える影響

    平山 敦士, 寳澤 篤, 成松 宏人, 川崎 良

    日本循環器病予防学会誌　51　(2)　142-142　2016/05

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  140. Associations of 24-h Urinary Sodium/potassium (Na/K) Ratio with Recommended Intakes of Na and K: The INTERMAP Study

    Toshiyuki Iwahori, Katsuyuki Miura, Hirotsugu Ueshima, Queenie Chan, Nagako Okuda, Katsushi Yoshita, Alan R. Dyer, Paul Elliott, Jeremiah Stamler

    CIRCULATION　133　2016/03

    ISSN： 0009-7322

    eISSN： 1524-4539

  141. 三世代コホート調査の進捗について

    目時 弘仁, 石黒 真美, 小原 拓, 佐藤 ゆき, 菊谷 昌浩, 栗山 進一, 寳澤 篤, 大隅 典子, 清元 秀泰, 菅原 準一, 鈴木 洋一, 冨永 悌二, 布施 昇男, 峯岸 直子, 辻 一郎, 呉 繁夫, 八重樫 伸生, 山本 雅之

    宮城県公衆衛生学会会誌　(48)　10-10　2016/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  142. 東日本大震災後の宮城県沿岸部における治療中断東北メディカル・メガバンク事業 地域住民コホート調査

    中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 中谷 純, 峯岸 直子, 布施 昇男, 鈴木 洋一, 菅原 準一, 菊谷 昌浩, 富田 博秋, 清元 秀泰, 栗山 進一, 辻 一郎, 呉 繁夫, 山本 雅之, 寳澤 篤, 丹野 高三, 佐々木 亮平, 坂田 清美

    宮城県公衆衛生学会会誌　(48)　11-11　2016/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  143. 東北メディカル・メガバンク事業 地域住民コホート調査における眼軸長検査

    布施 昇男, 本間 慶, 高井 貴子, 荻島 創一, 清元 秀泰, 菅原 準一, 鈴木 洋一, 菊谷 昌浩, 栗山 進一, 寳澤 篤, 八重樫 伸生, 呉 繁夫, 山本 雅之

    日本眼科学会雑誌　120　(臨増)　200-200　2016/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  144. Unemployment risk among individuals undergoing medical treatment for chronic diseases

    N. Nakaya, T. Nakamura, N. Tsuchiya, I. Tsuji, A. Hozawa, H. Tomita

    OCCUPATIONAL MEDICINE-OXFORD　66　(2)　143-149　2016/03

    DOI： 10.1093/occmed/kqv159 　

    ISSN： 0962-7480

    eISSN： 1471-8405

  145. カルシウム摂取量と日常生活動作(ADL)との関連:NIPPON DATA90

    小暮真奈, 土屋菜歩, 成田暁, 寳澤篤, 早川岳人, 奥田奈賀子, 宮川尚子, 三浦克之, 三浦克之, 岡山明, 岡村智教, 上島弘嗣, 上島弘嗣

    Journal of Epidemiology (Web)　26　(Supplement 1)　76　2016/01/21

    ISSN： 1349-9092

  146. 三世代コホート調査の進捗と子どもの父母の質問票

    目時弘仁, 石黒真美, 石黒真美, 小原拓, 小原拓, 佐藤ゆき, 水野聖士, 水野聖士, 宮下真子, 宮下真子, 菊谷昌浩, 菊谷昌浩, 栗山進一, 栗山進一, 栗山進一, 寳澤篤, 寳澤篤, 大隅典子, 大隅典子, 清元秀泰, 清元秀泰, 菅原準一, 菅原準一, 鈴木洋一, 鈴木洋一, 冨永悌二, 冨永悌二, 布施昇男, 布施昇男, 峯岸直子, 峯岸直子, 辻一郎, 辻一郎, 呉繁夫, 呉繁夫, 八重樫伸生, 八重樫伸生, 山本雅之, 山本雅之

    Journal of Epidemiology (Web)　26　(Supplement 1)　105　2016/01/21

    ISSN： 1349-9092

  147. 随時尿Na/K比,随時尿からの推定食塩摂取量と血圧値の相関について―東北メディカル・メガバンク事業―

    寳澤篤, 清元秀泰, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 菅原準一, 布施昇男, 菊谷昌浩, 鈴木洋一, 荻島創一, 高井貴子, 峯岸直子, 栗山進一, 辻一郎, 呉繁夫, 丹野高三, 佐々木亮平, 坂田清美

    Journal of Epidemiology (Web)　26　(Supplement 1)　123　2016/01/21

    ISSN： 1349-9092

  148. 東日本大震災後の宮城県におけるメタボリック症候群の規定要因:地域住民コホート調査

    中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 丹野高三, 佐々木亮平, 坂田清美, 高井貴子, 荻島創一, 峯岸直子, 清元秀泰, 鈴木洋一, 菅原準一, 布施昇男, 菊谷昌浩, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    Journal of Epidemiology (Web)　26　(Supplement 1)　124　2016/01/21

    ISSN： 1349-9092

  149. 随時尿Na/K比,随時尿からの推定食塩摂取量と血圧値の相関について―東北メディカル・メガバンク事業―

    寳澤篤, 清元秀泰, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 菅原準一, 布施昇男, 菊谷昌浩, 鈴木洋一, 荻島創一, 高井貴子, 峯岸直子, 栗山進一, 辻一郎, 呉繁夫, 丹野高三, 佐々木亮平, 坂田清美

    Journal of Epidemiology (Web)　26　(Supplement 1)　123　2016/01/21

    ISSN： 0917-5040

  150. 東日本大震災後の宮城県におけるメタボリック症候群の規定要因:地域住民コホート調査

    中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 丹野高三, 佐々木亮平, 坂田清美, 高井貴子, 荻島創一, 峯岸直子, 清元秀泰, 鈴木洋一, 菅原準一, 布施昇男, 菊谷昌浩, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

    Journal of Epidemiology (Web)　26　(Supplement 1)　124　2016/01/21

    ISSN： 0917-5040

  151. カルシウム摂取量と日常生活動作(ADL)との関連:NIPPON DATA90

    小暮真奈, 土屋菜歩, 成田暁, 寳澤篤, 早川岳人, 奥田奈賀子, 宮川尚子, 三浦克之, 三浦克之, 岡山明, 岡村智教, 上島弘嗣, 上島弘嗣

    Journal of Epidemiology (Web)　26　(Supplement 1)　76　2016/01/21

    ISSN： 0917-5040

  152. Relationship of Consumption of Meals Including Grain, Fish and Meat, and Vegetable Dishes to the Prevention of Nutrient Deficiency: The INTERMAP Toyama Study.

    Tatsuya Koyama, Katsushi Yoshita, Masaru Sakurai, Katsuyuki Miura, Yuchi Naruse, Nagako Okuda, Akira Okayama, Jeremiah Stamler, Hirotsugu Ueshima, Hideaki Nakagawa

    Journal of nutritional science and vitaminology　62　(2)　101-7　2016

    DOI： 10.3177/jnsv.62.101 　

    More details Close

    A Japanese-style diet consists of meals that include grain (shushoku), fish and meat (shusai), and vegetable dishes (fukusai). Little is known about the association of such meals (designated well-balanced meals hereafter) with nutrient intake. We therefore examined the frequency of well-balanced meals required to prevent nutrient deficiency. Participants were Japanese people, ages 40 to 59 y, from Toyama, recruited for INTERMAP, in an international population-based study. Each person provided 4 in-depth 24-h dietary recalls (149 men, 150 women). The prevalence of risk ratios of not meeting the Dietary Reference Intakes for Japanese (2015) was calculated. Well-balanced diets were assessed by the Japanese Food Guide Spinning Top. We counted the frequencies of meals in which participants consumed 1.0 or more servings of all 3 dishes categories. We divided the frequency of consumption of well-balanced meals into the following 4 groups: <1.00 time/d, 1.00-1.49 times/d, 1.50-1.74 times/d, and ≥1.75 times/d. Compared with participants in the highest frequency group for well-balanced meals, those who consumed well-balanced meals less than once a day had a higher risk of not meeting the adequate intake for potassium and the recommended dietary allowance for vitamin A. Those who consumed well-balanced meals on average less than 1.50 times per day had a higher risk of not meeting the recommended dietary allowance for calcium and vitamin C. Our results suggest that individuals should on average consume well-balanced meals more than 1.5 times per day to prevent calcium and vitamin C deficiencies.

  153. The Relationship between Very High Levels of Serum High-Density Lipoprotein Cholesterol and Cause-Specific Mortality in a 20-Year Follow-Up Study of Japanese General Population

    Aya Hirata, Tomonori Okamura, Daisuke Sugiyama, Kazuyo Kuwabara, Aya Kadota, Akira Fujiyoshi, Katsuyuki Miura, Nagako Okuda, Takayoshi Ohkubo, Akira Okayama, Hirotsugu Ueshima

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS　23　(7)　800-809　2016

    DOI： 10.5551/jat.33449 　

    ISSN： 1340-3478

    eISSN： 1880-3873

  154. 東北メディカル・メガバンク地域住民コホート調査(宮城)における高血圧の規定要因

    寳澤 篤, 清元 秀泰, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小原 拓, 目時 弘仁, 丹野 高三, 中谷 純, 菊谷 昌浩, 栗山 進一, 辻 一郎, 呉 繁夫, 山本 雅之

    日本公衆衛生学会総会抄録集　74回　260-260　2015/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  155. 家庭血圧は理想的環境下で測定した診察室血圧より冠動脈石灰化と強く関連するか? Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA)

    佐藤 敦, 有馬 久富, 寳澤 篤, 久松 隆史, 門田 文, 藤吉 朗, 宮川 尚子, Zaid Maryam, 鳥居 さゆ希, 大久保 孝義, 岡村 智教, 関川 暁, 三浦 克之, 上島 弘嗣

    日本高血圧学会総会プログラム・抄録集　38回　397-397　2015/10

    Publisher: (NPO)日本高血圧学会

  156. 東北メディカル・メガバンク地域住民コホート調査(宮城)における高血圧の規定要因

    寳澤 篤, 清元 秀泰, 中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 小原 拓, 目時 弘仁, 丹野 高三, 中谷 純, 菊谷 昌浩, 栗山 進一, 辻 一郎, 呉 繁夫, 山本 雅之

    日本公衆衛生学会総会抄録集　74回　260-260　2015/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  157. 東日本大震災後の高血圧の治療中断と関連する要因 地域住民コホート調査

    中谷 直樹, 中村 智洋, 土屋 菜歩, 成田 暁, 丹野 高三, 佐々木 亮平, 坂田 清美, 中谷 純, 菊谷 昌浩, 清元 秀泰, 栗山 進一, 辻 一郎, 呉 繁夫, 山本 雅之, 寳澤 篤

    日本公衆衛生学会総会抄録集　74回　261-261　2015/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  158. 東日本大震災後の宮城県における歯科受診状況と関連因子についての検討

    土屋 菜歩, 坪井 明人, 白石 成, 中谷 直樹, 中村 智洋, 成田 暁, 小暮 真奈, 鈴木 洋一, 菊谷 昌浩, 富田 博秋, 栗山 進一, 辻 一郎, 呉 繁夫, 山本 雅之, 寳澤 篤

    日本公衆衛生学会総会抄録集　74回　261-261　2015/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  159. 宮城県地域住民における心理的苦痛と喫煙行動の関連についての検討

    成田 暁, 中谷 直樹, 中村 智洋, 土屋 菜歩, 小暮 真奈, 丹野 高三, 佐々木 亮平, 坂田 清美, 富田 博秋, 栗山 進一, 辻 一郎, 呉 繁夫, 山本 雅之, 寳澤 篤

    日本公衆衛生学会総会抄録集　74回　296-296　2015/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  160. 東日本大震災後の睡眠薬服用開始に関連する規定要因の検討 地域住民コホート調査

    中村 智洋, 富田 博秋, 中谷 直樹, 土屋 菜歩, 成田 暁, 中谷 純, 菊谷 昌浩, 栗山 進一, 辻 一郎, 呉 繁夫, 山本 雅之, 寳澤 篤, 丹野 高三, 佐々木 亮平, 坂田 清美

    日本公衆衛生学会総会抄録集　74回　296-296　2015/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  161. 日本人全ゲノムファレンスパネルの構築と今後

    日本遺伝学会大会プログラム・予稿集　87th　73　2015/09

  162. 東北メディカル・メガバンク事業-地域住民コホート調査のデザインと経過報告(眼圧検査)

    布施 昇男, 本間 慶, 高井 貴子, 清元 秀泰, 菅原 準一, 鈴木 洋一, 菊谷 昌浩, 栗山 進一, 寳澤 篤, 八重樫 伸生, 山本 雅之

    日本緑内障学会抄録集　26回　130-130　2015/09

    Publisher: 日本緑内障学会

  163. Employment status among non-retired cancer survivors in Japan

    H. Ito, A. Hozawa, H. Yamashita, I. Kubota, K. Nemoto, T. Yoshioka, T. Kayama, M. Murakami

    EUROPEAN JOURNAL OF CANCER CARE　24　(5)　718-723　2015/09

    DOI： 10.1111/ecc.12304 　

    ISSN： 0961-5423

    eISSN： 1365-2354

  164. The association between urinary sodium to potassium ratio and blood pressure by salt consumption level: the Takahata study

    A. Hirayama, T. Konta, R. Kawasaki, T. Watanabe, A. Hozawa, T. Kayama, I. Kubota

    EUROPEAN HEART JOURNAL　36　1186-1186　2015/08

    ISSN： 0195-668X

    eISSN： 1522-9645

  165. 認知機能低下に対する基本チェックリストの予測妥当性の検証:大崎コホート2006研究

    遠又靖丈, 杉山賢明, 海法悠, 菅原由美, 柿崎真沙子, 寳澤篤, 辻一郎

    東北医学雑誌　127　(1)　83-84　2015/06/25

    ISSN： 0040-8700

  166. 東北メディカル・メガバンク 地域住民コホート宮城エリアにおける随時尿Na/K比の内陸部・沿岸部比較

    寳澤 篤, 中谷 直樹, 中村 智洋, 土屋 菜歩, 小暮 真奈, 丹野 高三, 佐々木 亮平, 坂田 清美, 中谷 純, 峯岸 直子, 清元 秀泰, 菅原 準一, 布施 昇男, 菊谷 昌浩, 鈴木 洋一, 富田 博秋, 栗山 進一, 辻 一郎, 呉 繁夫, 八重樫 伸生, 山本 雅之

    日本循環器病予防学会誌　50　(2)　126-126　2015/06

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  167. 岩手県被災地域住民の随時尿中ナトリウム/カリウム濃度比 東北メディカル・メガバンク地域住民コホート研究ベースライン調査

    丹野 高三, 佐々木 亮平, 坂田 清美, 寳澤 篤, 栗山 進一, 辻 一郎, 遠藤 龍人, 小林 誠一郎, 八谷 剛史, 佐藤 衛, 小笠原 邦昭, 中村 元行, 人見 次郎, 祖父江 憲治

    日本循環器病予防学会誌　50　(2)　136-136　2015/06

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  168. 東日本大震災被災者の喪失と悲嘆のプロファイル

    小林 奈津子, 新宮 古都美, 庄子 朋香, 北田 友子, 中谷 直樹, 中村 智洋, 土屋 菜歩, 吉田 弘和, 菊地 紗耶, 本多 奈美, 松岡 洋夫, 中島 聡美, 寳澤 篤, 辻 一郎, 富田 博秋

    精神神経学雑誌　(2015特別)　S364-S364　2015/06

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  169. High circulating adiponectin levels predict decreased muscle strength among older adults aged 70 years and over: A prospective cohort study

    C. Huang, Y. Tomata, M. Kakizaki, Y. Sugawara, A. Hozawa, H. Momma, I. Tsuji, R. Nagatomi

    NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES　25　(6)　594-601　2015/06

    DOI： 10.1016/j.numecd.2015.03.010 　

    ISSN： 0939-4753

    eISSN： 1590-3729

  170. 東日本大震災後の小中学生の保護者が抱く子どもの不安と悩みの特徴 宮城県南部の実態調査から

    佐藤 ゆき, 菊谷 昌浩, 宮下 真子, 山中 千鶴, 石黒 真美, 小原 拓, 目時 弘仁, 土屋 菜歩, 中村 智洋, 中谷 直樹, 寳澤 篤, 辻 一郎, 呉 繁夫, 八重樫 伸生, 栗山 進一

    小児保健研究　74　(講演集)　139-139　2015/05

    Publisher: (公社)日本小児保健協会

    ISSN： 0037-4113

  171. Long-term outcomes associated with prolonged PR interval in the general Japanese population

    Takashi Hisamatsu, Katsuyuki Miura, Akira Fujiyoshi, Tomonori Okamura, Takayoshi Ohkubo, Shin-ya Nagasawa, Minoru Horie, Akira Okayama, Hirotsugu Ueshima

    INTERNATIONAL JOURNAL OF CARDIOLOGY　184　291-293　2015/04

    DOI： 10.1016/j.ijcard.2015.02.028 　

    ISSN： 0167-5273

    eISSN： 1874-1754

  172. High-density lipoprotein particle concentration and subclinical atherosclerosis of the carotid arteries in Japanese men

    Maryam Zaid, Akira Fujiyoshi, Katsuyuki Miura, Robert D. Abbott, Tomonori Okamura, Naoyuki Takashima, Sayuki Torii, Yoshino Saito, Takashi Hisamatsu, Naoko Miyagawa, Takayoshi Ohkubo, Aya Kadota, Akira Sekikawa, Hiroshi Maegawa, Yasuyuki Nakamura, Kenichi Mitsunami, Hirotsugu Ueshima

    ATHEROSCLEROSIS　239　(2)　444-450　2015/04

    DOI： 10.1016/j.atherosclerosis.2015.01.031 　

    ISSN： 0021-9150

    eISSN： 1879-1484

  173. LC‐MSによる大規模コホートメタボローム解析

    三枝大輔, 加藤恭丈, 小柴生造, 元池育子, 荻島創一, 本橋ほづみ, 菅原準一, 中谷純, 寳澤篤, 峯岸直子, 木下賢吾, 田邉修, 山本雅之

    日本農芸化学会大会講演要旨集(Web)　2015　4SY19-2 (WEB ONLY)　2015/03/05

    ISSN： 2186-7976

  174. 被災地健康調査における家庭血圧計診断に基づく高血圧症の実態

    清元 秀泰, 寳澤 篤, 田中 由香利, 奥田 拓史, 菅原 準一, 坪井 明人, 布施 昇男, 栗山 進一, 瀧 靖之, 辻 一郎, 阿部 倫明, 高井 貴子, 八重樫 伸生, 山本 雅之, 伊藤 貞嘉

    日本高血圧学会総会プログラム・抄録集　37回　442-442　2014/10

    Publisher: (NPO)日本高血圧学会

  175. 認知機能低下に対する基本チェックリストの予測妥当性の検証 大崎コホート2006研究

    遠又 靖丈, 杉山 賢明, 海法 悠, 菅原 由美, 柿崎 真沙子, 寳澤 篤, 辻 一郎

    日本公衆衛生学会総会抄録集　73回　223-223　2014/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  176. 東日本大震災での笑いの規定要因と精神的健康度の推測 七ヶ浜健康増進プロジェクト

    中村 智洋, 中谷 直樹, 土屋 菜歩, 辻 一郎, 寳澤 篤, 富田 博秋

    日本公衆衛生学会総会抄録集　73回　239-239　2014/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  177. 東日本大震災の被災地における慢性疾患治療と就労の関連 七ヶ浜健康増進プロジェクト

    中谷 直樹, 中村 智洋, 土屋 菜歩, 辻 一郎, 寳澤 篤, 富田 博秋

    日本公衆衛生学会総会抄録集　73回　270-270　2014/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  178. ソーシャルキャピタルと健康状態との関連 家屋の被災程度との交互作用の検討

    土屋 菜歩, 中谷 直樹, 中村 智洋, 辻 一郎, 寳澤 篤, 富田 博秋

    日本公衆衛生学会総会抄録集　73回　480-480　2014/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  179. メタボリックシンドロームに注目した健診の評価

    寳澤 篤, 八谷 寛

    日本医事新報　(4711)　59-60　2014/08

    Publisher: (株)日本医事新報社

    ISSN： 0385-9215

  180. 各種災害関連ストレスが東日本大震災沿岸部被災者の精神的健康に及ぼす影響の検討

    鈴木 大輔, 中谷 直樹, 中村 智洋, 中島 聡美, 金 吉晴, 辻 一郎, 寳澤 篤, 富田 博秋

    日本社会精神医学会雑誌　23　(3)　259-259　2014/08

    Publisher: (一社)日本社会精神医学会

    ISSN： 0919-1372

  181. 検診・特定健診の検証

    寳澤 篤, 大久保 孝義

    日本医事新報　(4698)　64-64　2014/05

    Publisher: (株)日本医事新報社

    ISSN： 0385-9215

  182. 腎疾患個別化医療実現に向けた健常人ゲノムコホートの構築

    清元 秀泰, 阿部 倫昭, 奥田 拓史, 岡村 将史, 宮崎 真理子, 寳澤 篤, 栗山 進一, 高井 貴子, 長崎 正朗, 峯岸 直子, 安田 純, 森 建文, 中谷 純, 菅原 準一, 八重樫 伸生, 佐藤 博, 山本 雅之, 伊藤 貞嘉

    日本腎臓学会誌　56　(3)　352-352　2014/05

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

  183. A comparison of risk factors for mortality from heart failure in Asian and non-Asian populations: An overview of individual participant data from 32 prospective cohorts from the Asia-Pacific Region

    Rachel R. Huxley, Federica Barzi, Jean Woo, Graham Giles, Tai Hing Lam, Kazem Rahimi, Suma Konety, Takayoshi Ohkubo, Sun Ha Jee, Xianghua Fang, Mark Woodward

    BMC CARDIOVASCULAR DISORDERS　14　2014/05

    DOI： 10.1186/1471-2261-14-61 　

    ISSN： 1471-2261

  184. Outcome-Driven Thresholds for Home Blood Pressure Measurement: International Database of HOme blood pressure in relation to Cardiovascular Outcome.

    T. J. Niiranen, K. Asayama, L. Thijs, J. K. Johansson, T. Ohkubo, M. Kikuya, J. Boggia, A. Hozawa, E. Sandoya, G. S. Stergiou, Tsuji, I, A. M. Jula, Y. Imai, J. A. Staessen

    HYPERTENSION　63　(4)　E91-E91　2014/04

    DOI： 10.1161/HYP.0000000000000004 　

    ISSN： 0194-911X

    eISSN： 1524-4563

  185. 地域子ども長期健康調査のこころとからだの支援

    山中 千鶴, 宮下 真子, 成川 洋子, 石黒 真美, 小原 拓, 目時 弘仁, 菊谷 昌浩, 寳澤 篤, 辻 一郎, 栗山 進一

    宮城県公衆衛生学会会誌　(46)　4-4　2014/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  186. 【喫煙・飲酒習慣と動脈硬化】 喫煙は過去においてなぜ循環器疾患の危険因子として不明瞭であったか

    寳澤 篤

    動脈硬化予防　12　(4)　26-30　2014/02

    Publisher: (株)メジカルビュー社

    ISSN： 1347-7056

  187. 高齢者における血清アディポネクチンと下肢筋力の関連に関する1年間の追跡研究:鶴ケ谷プロジェクト

    黄聡, 寶澤篤, 遠又靖丈, 柿崎真沙子, 菅原由美, 門間陽樹, 辻一郎, 永富良一, 永富良一

    J Epidemiol　24　(Supplement 1)　92　2014/01/23

    ISSN： 0917-5040

  188. 東北メディカル・メガバンク事業―地域住民コホート調査に関する経過報告

    寶澤篤, 寶澤篤, 寶澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 菊谷昌浩, 目時弘仁, 小原拓, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 中谷直樹, 中村智洋, 土屋菜歩, 菊谷昌浩, 目時弘仁, 小原拓, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 富田博秋, 富田博秋, 富田博秋, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生, 山本雅之, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生, 山本雅之

    J Epidemiol　24　(Supplement 1)　67　2014/01/23

    ISSN： 0917-5040

  189. 東北メディカル・メガバンク事業―三世代コホート調査に関する経過報告

    目時弘仁, 小原拓, 石黒真美, 成川洋子, 菊谷昌浩, 目時弘仁, 小原拓, 石黒真美, 成川洋子, 菊谷昌浩, 栗山進一, 栗山進一, 栗山進一, 中谷直樹, 寶澤篤, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 中谷直樹, 寶澤篤, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 富田博秋, 富田博秋, 富田博秋, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生

    J Epidemiol　24　(Supplement 1)　67　2014/01/23

    ISSN： 0917-5040

  190. 網膜動脈血管径は将来の微量アルブミン尿の発症に関連する

    平山敦士, 川崎良, 今田恒夫, 邵力, 成松宏人, 大谷勝実, 寳澤篤, 嘉山孝正, 久保田功, 深尾彰

    Journal of Epidemiology　24　(Supplement 1)　2014

    ISSN： 0917-5040

  191. 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 1.血圧および高血圧治療状況など50年間の推移

    NAGAI MASATO, MIURA KATSUYUKI, YOSHITA KATSUSHI, HOZAWA ATSUSHI, OKUDA NAKAKO, MIYAMATSU NAOMI, FUKUHARA MASAYO, HIGASHI AKANE, NOMURA KYOKO, ISHIGURO AYA, TAKEZAKI TOSHIRO

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成25年度 総括・分担研究報告書　89-97　2014

  192. 東北メディカル・メガバンク事業 三世代コホート調査の進捗について

    目時 弘仁, 石黒 真美, 小原 拓, 佐藤 ゆき, 菊谷 昌浩, 栗山 進一, 寳澤 篤, 大隅 典子, 清元 秀泰, 菅原 準一, 鈴木 洋一, 冨永 悌二, 布施 昇男, 峯岸 直子, 辻 一郎, 呉 繁夫, 八重樫 伸生, 山本 雅之

    DOHaD研究　3　(1)　46-46　2014

    Publisher: 日本DOHaD研究会

    ISSN： 2187-2597

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  193. 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 9.日本人における長鎖n‐3不飽和脂肪酸摂取と循環器疾患死亡リスクの関連

    MIYAGAWA NAOKO, MIURA KATSUYUKI, OKUDA NAKAKO, KADOWAKI TAKASHI, TAKASHIMA NAOTAKA, NAGASAWA SHIN'YA, NAKAMURA YASUYUKI, MATSUMURA YASUHIRO, HOZAWA ATSUSHI, FUJIYOSHI AKIRA, HISAMATSU TAKASHI, YOSHITA KATSUSHI, SEKIKAWA AKIRA, OKUBO TAKAYOSHI, ABBOTT ROBERT D, OKAMURA TOMONORI, OKAYAMA AKIRA, UESHIMA HIROTSUGU

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成25年度 総括・分担研究報告書　210-211　2014

  194. [Scientific Statement] Report of the Salt Reduction Committee of the Japanese Society of Hypertension(1) Role of salt in hypertension and cardiovascular diseases

    Katsuyuki Ando, Hiroo Kawarazaki, Katsuyuki Miura, Hideo Matsuura, Yoshihiko Watanabe, Katsushi Yoshita, Minoru Kawamura, Miho Kusaka, Hisashi Kai, Takuya Tsuchihashi, Yuhei Kawano

    Hypertension Research　36　(12)　1009-1019　2013/12

    DOI： 10.1038/hr.2013.102 　

    ISSN： 0916-9636 1348-4214

  195. Report of the Salt Reduction Committee of the Japanese Society of Hypertension (2) Goal and strategies of dietary salt reduction in the management of hypertension

    Katsuyuki Miura, Katsuyuki Ando, Takuya Tsuchihashi, Katsushi Yoshita, Yoshihiko Watanabe, Hiroo Kawarazaki, Hideo Matsuura, Miho Kusaka, Hisashi Kai, Minoru Kawamura, Yuhei Kawano

    HYPERTENSION RESEARCH　36　(12)　1020-1025　2013/12

    DOI： 10.1038/hr.2013.105 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  196. 尿中アルブミン排泄正常高値は日本人地域住民の高血圧発症の予測に有用である。高畠研究

    平山 敦士, 今田 恒夫, 寶澤 篤, 川崎 良, 渡邉 哲, 深尾 彰, 久保田 功

    日本高血圧学会総会プログラム・抄録集　36回　321-321　2013/10

    Publisher: (NPO)日本高血圧学会

  197. 慢性疾患治療者における心理的苦痛に関する研究 七ヶ浜健康増進プロジェクト

    中谷 直樹, 中村 智洋, 辻 一郎, 寳澤 篤, 富田 博秋

    日本公衆衛生学会総会抄録集　72回　198-198　2013/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  198. 東日本大震災における喫煙・飲酒の行動変化と規定要因 七ヶ浜健康増進プロジェクト

    中村 智洋, 中谷 直樹, 辻 一郎, 寳澤 篤, 富田 博秋

    日本公衆衛生学会総会抄録集　72回　198-198　2013/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  199. Slight increase of urinary albumin excretion predicts incident hypertension in the Japanese general population

    A. Hirayama, T. Konta, A. Hozawa, T. Watanabe, I. Kubota

    EUROPEAN HEART JOURNAL　34　301-302　2013/08

    ISSN： 0195-668X

    eISSN： 1522-9645

  200. 血清総コレステロール値と要介護認定リスクに関する前向きコホート研究 鶴ヶ谷プロジェクト

    星 玲奈, 遠又 靖丈, 柿崎 真沙子, 坪谷 透, 永井 雅人, 渡邊 生恵, 寳澤 篤, 辻 一郎

    日本公衆衛生雑誌　60　(8)　435-443　2013/08

    Publisher: 日本公衆衛生学会

    DOI： 10.11236/jph.60.8_435 　

    ISSN： 0546-1766

    eISSN： 2187-8986

  201. White Rice Consumption and Incident Risk for Type 2 Diabetes Mellitus in Japanese Men and Women

    Masaru Sakurai, Koshi Nakamura, Katsuyuki Miura, Toshinari Takamura, Katsushi Yoshita, Shin-Ya Nagasawa, Yuko Morikawa, Masao Ishizaki, Teruhiko Kido, Yuchi Naruse, Hideaki Nakagawa

    DIABETES　62　A399-A399　2013/07

    ISSN： 0012-1797

    eISSN： 1939-327X

  202. 東日本大震災沿岸部被災者の精神的健康の変遷と現況

    鈴木 大輔, 築田 美抄, 上田 穫, 中谷 直樹, 金 吉晴, 辻 一郎, 寶澤 篤, 富田 博秋

    精神神経学雑誌　(2013特別)　S-568　2013/05

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  203. Plasma Phospholipid Fatty Acid Composition as a Biomarker of Habitual Dietary Fat Intake: The INTERMAP/INTERLIPID Study

    Naoko Miyagawa, Katsuyuki Miura, Akira Sekikawa, Rhobert W. Evans, Nagako Okuda, Akira Fujiyoshi, Katsushi Yoshita, Bradley Willcox, Kamal H. Masaki, Beatriz L. Rodriguez, Kiyomi Sakata, Hideaki Nakagawa, Shigeyuki Saitoh, Akira Okayama, Lewis H. Kuller, Paul Elliott, Jeremiah Stamler, Hirotsugu Ueshima

    CIRCULATION　127　(12)　2013/03

    ISSN： 0009-7322

    eISSN： 1524-4539

  204. 網膜血管径と、低アディポネクチン血症を含む動脈硬化危険因子との関連の検討

    本間 慶, 川崎 良, 菅野 彰, 斉藤 公子, 田邊 祐資, 後藤 早紀子, 成松 宏人, 寳澤 篤, 久保田 功, 加藤 丈夫, 嘉山 孝正, 山下 英俊

    日本眼科学会雑誌　117　(臨増)　353-353　2013/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  205. 睡眠時間と総死亡・死因別死亡リスク 大崎国保コホート研究

    柿崎 真沙子, 栗山 進一, 中谷 直樹, 曽根 稔雅, 永井 雅人, 菅原 由美, 寳澤 篤, 辻 一郎

    宮城県公衆衛生学会会誌　(45)　4-4　2013/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  206. 東北メディカル・メガバンク事業 地域コホート計画について

    寳澤 篤, 菊谷 昌浩, 目時 弘仁, 小原 拓, 石黒 真美, 栗山 進一, 辻 一郎

    宮城県公衆衛生学会会誌　(45)　7-7　2013/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  207. 東北メディカル・メガバンクにおける地域子どもコホート事業について

    菊谷 昌浩, 石黒 真美, 小原 拓, 目時 弘仁, 寳澤 篤, 辻 一郎, 栗山 進一

    宮城県公衆衛生学会会誌　(45)　10-10　2013/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  208. Impact Of Total Energy Intake On Stroke Mortality Is Greater Than That Of Coronary Heart Disease: A 24-year Follow-up Of Representative Japanese (NIPPON DATA80), 1980-2004 Peer-reviewed

    Masato Nagai, Akira Fujiyoshi, Takayoshi Ohkubo, Katsuyuki Miura, Nagako Okuda, Takehito Hayakawa, Katsushi Yoshita, Yusuke Arai, Hideaki Nakagawa, Koshi Nakamura, Naoko Miyagawa, Naoyuki Takashima, Aya Kadota, Yoshitaka Murakami, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima

    STROKE　44　(2)　2013/02

    ISSN： 0039-2499

    eISSN： 1524-4628

  209. 【これからの人間ドック健診】 (Part.1)人間ドック・健診の基礎 健診受診者は非受診者と比べ死亡率が低い

    寳澤 篤

    からだの科学 増刊　増刊　(これからの人間ドック健診)　10-14　2012/07

    Publisher: (株)日本評論社

    ISSN： 0303-0334

  210. 年齢構成を考慮した健診受診率と国保医療費の山形県内地域比較

    古川 雄彦, 寳澤 篤, 邵 力, 大谷 勝実, 村上 正泰, 白石 正, 深尾 彰

    東北公衆衛生学会誌　(61)　34-34　2012/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  211. 山形県脳卒中・心筋梗塞発症登録事業の進捗と展望

    成松 宏人, 寳澤 篤, 西山 悟史, 和根崎 真大, 渡邉 哲, 平山 敦士, 久保田 功, 深尾 彰

    東北公衆衛生学会誌　(61)　35-35　2012/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  212. Diabetes and life expectancy among Japanese - NIPPON DATA80

    Tanvir Chowdhury Turin, Yoshitaka Murakami, Katsuyuki Miura, Nahid Rumana, Aya Kadota, Takayoshi Ohkubo, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima

    DIABETES RESEARCH AND CLINICAL PRACTICE　96　(2)　E18-E22　2012/05

    DOI： 10.1016/j.diabres.2012.01.003 　

    ISSN： 0168-8227

  213. 血清グリセロールリン酸は2型糖尿病で増加している

    大門 真, 曽我 朋義, 寳澤 篤, 大泉 俊英, 海野 航, 高瀬 薫, 柄澤 繁, 神部 裕美, 和田 輝里子, 亀田 亘, 諏佐 真治, 嘉山 孝正, 齋藤 香織, 冨田 勝, 加藤 丈夫

    糖尿病　55　(Suppl.1)　S-215　2012/04

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

  214. 年齢構成を考慮した特定健診受診率と国保医療費の地域比較

    古川 雄彦, 寳澤 篤, 邵 力, 大谷 勝実, 村上 正泰, 深尾 彰

    山形県公衆衛生学会講演集　38回　44-44　2012/03

    Publisher: 山形県公衆衛生学会

  215. 虚血性心疾患男性患者の禁煙行動と関連要因

    松浪 容子, 大谷 勝実, 邵 力, 寳澤 篤, 深尾 彰

    日本禁煙学会雑誌　7　(1)　17-24　2012/02

    Publisher: (一社)日本禁煙学会

    ISSN： 1882-6806

  216. 自覚ストレスと循環器疾患死亡との関連 大崎国保コホート研究

    木幡 映美, 寳澤 篤, 柿崎 真沙子, 遠又 靖丈, 永井 雅人, 菅原 由美, 栗山 進一, 辻 一郎

    日本公衆衛生雑誌　59　(2)　82-91　2012/02

    Publisher: 日本公衆衛生学会

    DOI： 10.11236/jph.59.2_82 　

    ISSN： 0546-1766

    eISSN： 2187-8986

  217. 山形分子疫学コホート研究リクルート状況(第2報)

    寳澤篤, 成松宏人, 田宮元, 佐藤慎哉, 斎藤貴史, 北中千史, 加藤丈夫, 久保田功, 深尾彰, 山下英俊, 嘉山孝正, 嘉山孝正

    J Epidemiol　22　(Supplement 1)　109　2012/01/26

    ISSN： 0917-5040

  218. エネルギー摂取量の違いからみた食べる速さと肥満の関連:大崎コホート2006研究

    永井雅人, 高橋誠, 栗山進一, 栗山進一, 柿崎真沙子, 遠又靖丈, 渡邉崇, 寳澤篤, 寳澤篤

    J Epidemiol　22　(Supplement 1)　78　2012/01/26

    ISSN： 0917-5040

  219. 介護予防サービスの効果評価に関する研究 血清セレン,水酸化ビタミンDと要介護認定・死亡に関する研究—鶴ケ谷コホート研究—

    辻一郎, 寳澤篤, 菅原由美, 遠又靖丈, 柿崎真沙子, 坪谷透, 栗山進一

    介護予防サービスの効果評価に関する研究 平成23年度総括・分担研究報告書　22-27　2012

  220. 高齢者疫学調査による緑茶摂取と夜間頻尿との関連

    宮里 実, 中川 晴夫, 牛 凱軍, 泉 秀明, 川守田 直樹, 海法 康裕, 寶澤 篤, 永富 良一, 辻 一郎, 荒井 陽一

    日本排尿機能学会誌　22　(2)　336-336　2011/12

    Publisher: (一社)日本排尿機能学会

    ISSN： 1347-6513

  221. カルシウム摂取・カルシウムサプリメントと循環器疾患

    寳澤 篤

    循環器内科　70　(6)　602-606　2011/12

    Publisher: (有)科学評論社

    ISSN： 1884-2909

  222. 山形県内市町村における脳血管疾患年齢調整死亡率の比較

    寳澤 篤, 深尾 彰

    山形県対脳卒中治療研究会会誌　(26)　21-24　2011/11

    Publisher: 山形県対脳卒中治療研究会

    ISSN： 1345-3912

  223. 血清イソフラボン濃度と要介護認定・死亡の関連 鶴ヶ谷コホート研究

    寳澤 篤, 菅原 由美, 遠又 靖丈, 柿崎 真沙子, 坪谷 透, 大森 芳, 栗山 進一, 深尾 彰, 辻 一郎

    日本公衆衛生学会総会抄録集　70回　197-197　2011/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  224. 高齢者疫学調査による緑茶摂取と夜間頻尿との関連 緑茶摂取は夜間頻尿を増悪させるか、改善させるか

    宮里 実, 中川 晴夫, 牛 凱軍, 泉 秀明, 川守田 直樹, 海法 康裕, 寶澤 篤, 永富 良一, 辻 一郎, 荒井 陽一

    日本排尿機能学会誌　22　(1)　166-166　2011/09

    Publisher: (一社)日本排尿機能学会

    ISSN： 1347-6513

  225. 山形県内市町村における脳血管疾患・心疾患の年齢調整死亡率の比較

    寳澤 篤, 深尾 彰

    東北公衆衛生学会誌　(60)　30-30　2011/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  226. GAMMA-GLUTAMYLTRANSFERASE AND CANCER INCIDENCE: THE OHSAKI COHORT STUDY

    T. Tsuboya, S. Kuriyama, M. Nagai, A. Hozawa, Y. Sugawara, Y. Tomata, M. Kakizaki, Y. Nishino, I. Tsuji

    AMERICAN JOURNAL OF EPIDEMIOLOGY　173　S165-S165　2011/06

    ISSN： 0002-9262

    eISSN： 1476-6256

  227. ソーシャルキャピタルの地域差に関する研究

    坪谷 透, 栗山 進一, 遠又 靖丈, 中谷 直樹, 大森 芳, 松田, 高橋 英子, 寳澤 篤, 福地 成, 曽根 稔雅, 永井 雅人, 菅原 由美, 星 玲奈, 柿崎 真沙子, 辻 一郎

    宮城県公衆衛生学会会誌　(43)　11-11　2011/06

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  228. The association between neighborhood social capital and self-reported dentate status in elderly Japanese - The Ohsaki Cohort 2006 Study

    J. Aida, S. Kuriyama, K. Ohmori-Matsuda, A. Hozawa, K. Osaka, I. Tsuji

    COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY　39　(3)　239-249　2011/06

    DOI： 10.1111/j.1600-0528.2010.00590.x 　

    ISSN： 0301-5661

  229. Corrigendum to 'Gamma-Glutamyltransferase and mortality risk from heart disease and stroke in Japanese men and women: NIPPON DATA 90' (CVD Prevention and Control (10.1016/j.cvdpc.2010.03.003))

    Akira Fujiyoshi, Katsuyuki Miura, Atsushi Hozawa, Yoshitaka Murakami, Naoyuki Takashima, Nagako Okuda, Takashi Kadowaki, Yoshikuni Kita, Tomonori Okamura, Yasuyuki Nakamura, Takehito Hayakawa, Akira Okayama, Hirotsugu Ueshima

    CVD Prevention and Control　6　(2)　63　2011/06

    DOI： 10.1016/j.cvdpc.2011.02.002 　

    ISSN： 1875-4570

  230. Relationship between Peripheral Arterial Disease and Incident Disability among Japanese Elderly: the Tsurugaya Project.

    A. Nitta, A. Hozawa, S. Kuriyama, N. Nakaya, K. Ohmori-Matsuda, T. Sone, M. Kakizaki, N. Tomita, S. Ebihara, K. Furukawa, M. Ichiki, H. Arai, I. Tsuji

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY　59　S37-S37　2011/04

    ISSN： 0002-8614

  231. 地域高齢者の20歯以上保有と軽度認知機能障害の関連 1年の前向きコホート研究

    西村 一将, 大井 孝, 高津 匡樹, 服部 佳功, 坪井 明人, 菊池 雅彦, 大森 芳, 寶澤 篤, 辻 一郎, 渡邉 誠

    日本補綴歯科学会誌　3　(2)　126-134　2011/04

    Publisher: (公社)日本補綴歯科学会

    DOI： 10.2186/ajps.3.126 　

    ISSN： 1883-4426

  232. 高齢者疫学調査による緑茶摂取と夜間頻尿との関連 緑茶摂取は夜間頻尿を増悪させるか、改善させるか

    宮里 実, 中川 晴夫, 牛 凱軍, 泉 秀明, 川守田 直樹, 海法 康裕, 寶澤 篤, 永富 良一, 辻 一郎, 荒井 陽一

    日本泌尿器科学会雑誌　102　(2)　428-428　2011/03

    Publisher: (一社)日本泌尿器科学会

    DOI： 10.5980/jpnjurol.102.428_3 　

    ISSN： 0021-5287

  233. 健診受診の重要性

    寳澤 篤

    山形県医師会学術雑誌　41　67-80　2011/03

    Publisher: 山形県医師会

    ISSN： 1340-783X

  234. 牛乳・乳製品摂取量と総死亡および主要死因との関連(NIPPON DATA80)

    近藤今子, 尾島俊之, 中村美詠子, 早坂信哉, 寳澤篤, 斎藤重幸, 大西浩文, 赤坂憲, 早川岳人, 村上義孝, 奥田奈賀子, 三浦克之, 岡山明, 上島弘嗣

    J Epidemiol　21　(1 Supplement)　197　2011/01/21

    ISSN： 0917-5040

  235. 山形分子疫学コホート研究リクルート状況(第1報)

    寳澤篤, 成松宏人, 田宮元, 佐藤慎哉, 斎藤貴史, 北中千史, 加藤丈夫, 久保田功, 深尾彰, 山下英俊

    J Epidemiol　21　(1 Supplement)　242　2011/01/21

    ISSN： 0917-5040

  236. 血清総コレステロール値と要介護認定・死亡リスクに関する前向きコホート研究:鶴ケ谷プロジェクト

    星玲奈, 遠又靖丈, 柿崎真沙子, 坪谷透, 永井雅人, 渡邊生恵, 寳澤篤, 寳澤篤, 辻一郎

    J Epidemiol　21　(1 Supplement)　312　2011/01/21

    ISSN： 0917-5040

  237. 睡眠時間と要介護認定・死亡リスクに関する前向きコホート研究:鶴ケ谷プロジェクト

    柿崎真沙子, 上川康貴, 上川康貴, 中谷直樹, 曽根稔雅, 遠又靖丈, 坪谷透, 渡邊生恵, 寳澤篤, 栗山進一, 辻一郎

    J Epidemiol　21　(1 Supplement)　106　2011/01/21

    ISSN： 0917-5040

  238. n‐3系多価不飽和脂肪酸と要介護認定・死亡リスクに関する前向きコホート研究:鶴ケ谷プロジェクト

    遠又靖丈, 寳澤篤, 寳澤篤, 柿崎真沙子, 菅原由美, 坪谷透, 星玲奈, 渡邊生恵, 辻一郎

    J Epidemiol　21　(1 Supplement)　110　2011/01/21

    ISSN： 0917-5040

  239. 健診受診と死亡率の関連Propensity Score Matched Cohort Analysisを用いた検討

    寳澤篤, 寳澤篤, 栗山進一, 栗山進一, 渡邊生恵, 柿崎真沙子, 大森芳, 曽根稔雅, 永井雅人, 菅原由美, 新田明美, 新田明美, 李強, 大久保孝義, 大久保孝義, 村上義孝, 辻一郎

    J Epidemiol　21　(1 Supplement)　119　2011/01/21

    ISSN： 0917-5040

  240. ガンマグルタミン酸転移酵素(GGT)とがん罹患リスクとの関連:大崎国保コホート研究

    坪谷透, 栗山進一, 栗山進一, 永井雅人, 寳澤篤, 寳澤篤, 菅原由美, 柿崎真沙子, 西野善一, 辻一郎

    J Epidemiol　21　(1 Supplement)　85　2011/01/21

    ISSN： 0917-5040

  241. Increased sodium intake enhances the risk for developing hypertension in normotensive men and women: The HIPOP-OHP Study

    Junko TAMAKI, Yuriko KIKUCHI, Tomonori OKAMURA, Toru TAKEBATASHI, Katsushi YOSHITA, Nagako CHIBA, Taichiro TANAKA, Junko MINAI, Takayo TADA, Takashi KADOWAKI, Katsuyuki MIURA, Akira OKAYAMA, Hirotsugu UESHIMA, High-Risk, Population Strategy for Occupational Health, Promotion, research group

    AHA(atolanta)　-　(--)　---　2011

  242. 介護予防サービスの効果評価に関する研究 血清アディポネクチンと要介護認定・死亡に関する研究—鶴ケ谷コホート研究—

    辻一郎, 寳澤篤, 菅原由美, 遠又靖丈, 柿崎真沙子, 坪谷透, 栗山進一

    介護予防サービスの効果評価に関する研究 平成22年度総括・分担研究報告書　51-55　2011

  243. 介護予防サービスの効果評価に関する研究 1日の総睡眠時間,夜間睡眠時間,要介護認定の関連についての前向きコホート研究—鶴ケ谷プロジェクト—

    辻一郎, 柿崎真沙子, 上川康貴, 中谷直樹, 曽根稔雅, 遠又靖丈, 坪谷透, 渡邊生恵, 寳澤篤, 栗山進一

    介護予防サービスの効果評価に関する研究 平成22年度総括・分担研究報告書　56-60　2011

  244. 1年間の要介護認定発生に対する基本チェックリストの予測妥当性の検証 大崎コホート2006研究

    遠又 靖丈, 寳澤 篤, 大森 芳, 松田, 永井 雅人, 菅原 由美, 新田 明美, 栗山 進一, 辻 一郎

    日本公衆衛生雑誌　58　(1)　3-13　2011/01

    Publisher: 日本公衆衛生学会

    DOI： 10.11236/jph.58.1_3 　

    ISSN： 0546-1766

  245. 介護予防のエビデンスとプラクティス エビデンスからこれからの介護予防プログラムを考える 介護予防プログラムの有効性 系統的レビューの結果から『栄養』

    寳澤 篤

    日本公衆衛生学会総会抄録集　69回　72-72　2010/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  246. 緑茶摂取と要介護認定・死亡リスクに関する研究 大崎コホート2006研究

    遠又 靖丈, 寳澤 篤, 大森 芳, 永井 雅人, 菅原 由美, 星 玲奈, 曽根 稔雅, 栗山 進一, 辻 一郎

    日本公衆衛生学会総会抄録集　69回　367-367　2010/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  247. CKD患者における尿毒症物質の解析

    秋山 泰利, 鈴木 健弘, 豊原 敬文, 竹内 陽一, 三島 英換, 種本 雅之, 中山 昌明, 佐藤 博, 寳澤 篤, 辻 一郎, 伊藤 貞嘉, 曽我 朋義, 阿部 高明

    日本高血圧学会総会プログラム・抄録集　33回　365-365　2010/10

    Publisher: (NPO)日本高血圧学会

  248. 高齢者におけるNT-Pro BNPと要介護認定の関連 鶴ヶ谷コホート研究

    寳澤 篤, 菅原 由美, 遠又 靖丈, 柿崎 真沙子, 大森 芳, 中谷 直樹, 栗山 進一, 深尾 彰, 辻 一郎

    日本高血圧学会総会プログラム・抄録集　33回　380-380　2010/10

    Publisher: (NPO)日本高血圧学会

  249. Metabolomic profiling of uremic solutes in CKD patients (vol 33, pg 945, 2010)

    Takafumi Toyohara, Yasutoshi Akiyama, Takehiro Suzuki, Yoichi Takeuchi, Eikan Mishima, Masayuki Tanemoto, Ayako Momose, Naoko Toki, Hiroshi Sato, Masaaki Nakayama, Atsushi Hozawa, Ichiro Tsuji, Sadayoshi Ito, Tomoyoshi Soga, Takaaki Abe

    HYPERTENSION RESEARCH　33　(10)　1089-1089　2010/10

    DOI： 10.1038/hr.2010.158 　

    ISSN： 0916-9636

  250. IMPACT OF NOCTURIA ON FRACTURES AND MORTALITY IN OLDER POPULATION: CORRELATES WITH THE NIGHT-TIME FREQUENCY?

    H. Nakagawa, K. Niu, A. Hozawa, Y. Kaiho, Y. Ikeda, R. Imanishi, M. Miyazato, R. Nagatomi, Tsuji, I, Y. Arai

    INTERNATIONAL UROGYNECOLOGY JOURNAL　21　S246-S248　2010/08

    ISSN： 0937-3462

  251. 【嗜好品と高血圧・循環器病】 緑茶と高血圧・循環器病

    寳澤 篤, 栗山 進一

    血圧　17　(8)　688-691　2010/08

    Publisher: (株)先端医学社

    ISSN： 1340-4598

  252. うつ状態と介護保険要支援・要介護認定リスクとの関連 鶴ヶ谷プロジェクト

    大森 芳, 松田, 寳澤 篤, 曽根 稔雅, 小泉 弥生, 宗, 中谷 直樹, 栗山 進一, 鈴木 修治, 粟田 主一, 辻 一郎

    日本公衆衛生雑誌　57　(7)　538-549　2010/07

    Publisher: 日本公衆衛生学会

    DOI： 10.11236/jph.57.7_538 　

    ISSN： 0546-1766

  253. S2-1 過活動膀胱の疫学とリスクファクター(過活動膀胱(OAB)の基礎と臨床,シンポジウム2,第52回日本平滑筋学会総会)

    中川 晴夫, 池田 義弘, 寶澤 篤, 辻 一郎, 荒井 陽一

    日本平滑筋学会雑誌　14　(1)　"J-10"　2010/06/11

    Publisher: 日本平滑筋学会

    ISSN： 1342-8152

  254. CKD患者の尿毒症物質と早期診断マーカーの網羅的解析

    豊原 敬文, 秋山 泰利, 鈴木 健弘, 竹内 陽一, 三島 英換, 種本 雅之, 佐藤 博, 中山 昌明, 寳澤 篤, 辻 一郎, 伊藤 貞嘉, 曽我 朋義, 阿部 高明

    日本腎臓学会誌　52　(3)　340-340　2010/05

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  255. Dietary Salt Intake and Blood Pressure in a Representative Japanese Population: Baseline Analyses of NIPPON DATA80

    Katsuyuki Miura, Nagako Okuda, Tanvir Chowdhury Turin, Naoyuki Takashima, Hideaki Nakagawa, Koshi Nakamura, Katsushi Yoshita, Akira Okayama, Hirotsugu Ueshima

    JOURNAL OF EPIDEMIOLOGY　20　(Supplement_III)　S524-S530　2010/03

    DOI： 10.2188/jea.JE20090220 　

    ISSN： 0917-5040

  256. 高齢者の夜間頻尿の有無とその後の入院日数との関連について

    中川 晴夫, 海法 康裕, 池田 義弘, 寶澤 篤, 牛 凱群, 永富 良一, 辻 一郎, 荒井 陽一

    泌尿器外科　23　(臨増)　479-479　2010/03

    Publisher: 医学図書出版(株)

    ISSN： 0914-6180

  257. Integration of Data from NIPPON DATA80/90 and National Nutrition Survey in Japan: For Cohort Studies of Representative Japanese on Nutrition

    Nagako Okuda, Katsuyuki Miura, Katsushi Yoshita, Yasuhiro Matsumura, Akira Okayama, Yasuyuki Nakamura, Tomonori Okamura, Shigeyuki Saitoh, Kiyomi Sakata, Toshiyuki Ojima, Tanvir Chowdhury Turin, Hirotsugu Ueshima

    JOURNAL OF EPIDEMIOLOGY　20　S506-S514　2010/03

    DOI： 10.2188/jea.JE20090218 　

    ISSN： 0917-5040

  258. 高齢者の夜間排尿回数と死亡率との関連 高齢者の疫学調査からの5年間の前向きコホートによる解析

    中川 晴夫, 海法 康裕, 池田 義弘, 牛 凱軍, 寶沢 篤, 永富 良一, 辻 一郎, 荒井 陽一

    日本泌尿器科学会雑誌　101　(2)　227-227　2010/02

    Publisher: (一社)日本泌尿器科学会

    DOI： 10.5980/jpnjurol.101.227_2 　

    ISSN： 0021-5287

  259. 緑茶摂取と肝がん罹患に関する前向きコホート研究

    宇井あかね, 栗山進一, 柿崎真沙子, 曽根稔雅, 中谷直樹, 大森(松田)芳, 寳澤篤, 西野善一, 辻一郎

    J Epidemiol　20　(Supplement 1)　S112　2010/01/09

    ISSN： 0917-5040

  260. 介護予防サービスの効果評価に関する研究 Motor Fitness Scaleと要介護発生リスクに関する前向きコホート研究-鶴ケ谷プロジェクト-

    辻一郎, 栗山進一, 寳澤篤, 星真行

    介護予防サービスの効果評価に関する研究 平成21年度総括・分担研究報告書　2010

  261. IMPACT OF NOCTURIA ON FRACTURES AND MORTALITY IN OLDER POPULATION: CORRELATES WITH THE NIGHT-TIME FREQUENCY?

    H. Nakagawa, K. Niu, A. Hozawa, Y. Kaiho, Y. Ikeda, R. Imanishi, M. Miyazato, R. Nagatomi, Tsuji, I, Y. Arai

    NEUROUROLOGY AND URODYNAMICS　29　(6)　1050-1052　2010

    ISSN： 0733-2467

  262. Food group intake by birth cohort in the Japanese population

    Mieko Nakamura, Imako Kondo, Kaori Funahashi, Toshiyuki Ojima, Katsushi Yoshita, Yoshikazu Nakamura, Nagako Okuda, Katsuyuki Miura, Hirotsugu Ueshima, for the NIPPON, DATA Research Group

    J Epidemiol　20　(Suppl 1)　S230-S230　2010

  263. Associarion between food group intake and serum total cholesterol level in the Japanese population: NIPPON DATA80,90

    Imako Kondo, Kaori Funahashi, Mieko Nakamura, Toshiyuki Ojima, Katsushi Yoshita, Yoshikazu Nakamura, Nagako Okuda, Katsuyuki Miura, Hirotsugu Ueshima, for the NIPPON, DATA Research Group

    J Epidemiol　20　S232-S232　2010

  264. Intake of food group in Japan :NIPPON DATA 80,90

    Kaori Funahashi, Imako Kondo, Meiko Nakagawa, Toshiyuki Ojima, Katsushi Yoshita, Yoshizaki Nakmura, Nagako Okuda, Katsuyuki Miura, Hirotsugu Ueshima, for the NIPPON DATA, Research Group

    J Epidemiol　20　(Suppl 1)　S234-S234　2010

  265. 食生活・栄養素摂取状況が高齢者の健康寿命に与える影響に関する研究:NIPPON DATA80・90の追跡調査 牛乳・乳製品摂取量と総死亡および主要死因との関連

    尾島俊之, 近藤今子, 船橋香緒里, 中村美詠子, 早坂信哉, 寳澤篤, 斎藤重幸, 大西浩文, 赤坂憲, 早川岳人, 村上義孝

    食生活・栄養素摂取状況が高齢者の健康寿命に与える影響に関する研究:NIPPON DATA80・90の追跡調査 平成21年度 総括・分担研究報告書　89-94　2010

  266. Impact of physical activity and performance on medical care costs among the Japanese elderly

    Yang G, Niu K, Fujita K, Hozawa A, Ohmori-Matsuda K, Kuriyama S, Nakaya N, Ebihara S, Okazaki T, Guo H, Miura C, Takahashi H, Arai H, Tsuji I, Nagatomi R

    Geriatr Gerontol Int　00　(00)　000-000　2010

    DOI： 10.1111/j.1447-0594.2010.00651.x. 　

  267. 地域高齢者における20歯以上の保有と認知機能低下との関連 1年間の前向きコホート研究

    大井 孝, 西村 一将, 高津 匡樹, 服部 佳功, 坪井 明人, 大森 芳, 寶澤 篤, 辻 一郎, 渡邉 誠

    日本補綴歯科学会誌　2　(1)　E18-E18　2010/01

    Publisher: (公社)日本補綴歯科学会

    DOI： 10.2186/ajps.3.126 　

    ISSN： 1883-4426

  268. 介護予防サービスの効果評価に関する研究 緑茶摂取と肺炎死亡リスクに関する研究

    辻一郎, 渡邊生恵, 栗山進一, 柿崎真沙子, 曽根稔雅, 大森芳, 中谷直樹, 寳澤篤

    介護予防サービスの効果評価に関する研究 平成21年度総括・分担研究報告書　59-64　2010

  269. わが国における飲酒の実態ならびに飲酒に関連する生活習慣病,公衆衛生上の諸問題とその対策に関する総合的研究「飲酒習慣と生活習慣病の関連についての疫学的検討とその対策に関する研究」

    上島弘嗣, 門脇崇, 門脇紗也佳, 奥田奈賀子, 高嶋直敬, 三浦克之, 岡村智教, 寳澤篤, 中村保幸

    わが国における飲酒の実態ならびに飲酒に関連する生活習慣病、公衆衛生上の諸問題とその対策に関する総合的研究 平成19-21年度 総合研究報告書　42-51　2010

  270. 食生活・栄養素摂取状況が高齢者の健康寿命に与える影響に関する研究:NIPPON DATA80・90の追跡調査 日本人男女における血清γ‐glutamyltransferaseと心臓死亡および脳卒中死亡リスクとの関連:NIPPON DATA90

    藤吉朗, 三浦克之, 寳澤篤, 村上義孝, 高嶋直敬, 奥田奈賀子, 門脇崇, 喜多義邦, 岡村智教, 中村保幸, 早川岳人, 岡山明, 上島弘嗣

    食生活・栄養素摂取状況が高齢者の健康寿命に与える影響に関する研究:NIPPON DATA80・90の追跡調査 平成21年度 総括・分担研究報告書　281-296　2010

  271. 食生活・栄養素摂取状況が高齢者の健康寿命に与える影響に関する研究:NIPPON DATA80・90の追跡調査 中年期の食習慣と将来の日常活動度(ADL)の変化について

    中村保幸, 寳澤篤, TURIN Tanvir C, 高嶋直敬, 岡村智教, 早川岳人, 喜多義邦, 岡山明, 三浦克之, 上島弘嗣

    食生活・栄養素摂取状況が高齢者の健康寿命に与える影響に関する研究:NIPPON DATA80・90の追跡調査 平成21年度 総括・分担研究報告書　240-249　2010

  272. 食生活・栄養素摂取状況が高齢者の健康寿命に与える影響に関する研究:NIPPON DATA80・90の追跡調査 中壮年期の血圧値および喫煙習慣によるADL低下リスク評価チャート

    高嶋直敬, 三浦克之, 奥田奈賀子, 笠置文善, 児玉和紀, 寳澤篤, 村上義孝, 上島弘嗣

    食生活・栄養素摂取状況が高齢者の健康寿命に与える影響に関する研究:NIPPON DATA80・90の追跡調査 平成21年度 総括・分担研究報告書　27-28　2010

  273. Relationship of the Polyunsaturated to Saturated Fatty Acid Ratio to Cardiovascular Risk Factors and Metabolic Syndrome in Japanese: the INTERLIPID Study

    Zhao Guo, Katsuyuki Miura, Tanvir Chowdhury Turin, Atsushi Hozawa, Nagako Okuda, Tomonori Okamura, Shigeyuki Saitoh, Kiyomi Sakata, Hideaki Nakagawa, Akira Okayama, Katsushi Yoshita, Takashi Kadowaki, Sohel R. Choudhury, Yasuyuki Nakamura, Beatriz L. Rodriguez, J. David Curb, Paul Elliott, Jeremiah Stamler, Hirotsugu Ueshima

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS　17　(8)　777-784　2010

    DOI： 10.5551/jat.4135 　

    ISSN： 1340-3478

    eISSN： 1880-3873

  274. Relation of Gamma-Glutamyltransferase and Alcohol Drinking with Incident Diabetes: the HIPOP-OHP Study

    Atsushi Hozawa, Tomonori Okamura, Taichiro Tanaka, Katsuyuki Miura, Yuriko Kikuchi, Takashi Kadowaki, Katsushi Yoshita, Toru Takebayashi, Junko Tamaki, Junko Minai, Takayo Tada, Nagako Chiba, Akira Okayama, Hirotsugu Ueshima

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS　17　(2)　195-202　2010

    DOI： 10.5551/jat.3202 　

    ISSN： 1340-3478

    eISSN： 1880-3873

  275. Relationship between Peripheral Arterial Disease and Incident Disability among Elderly Japanese: the Tsurugaya Project

    Akemi Nitta, Atsushi Hozawa, Shinichi Kuriyama, Naoki Nakaya, Kaori Ohmori-Matsuda, Toshimasa Sone, Masako Kakizaki, Satoru Ebihara, Masataka Ichiki, Hiroyuki Arai, Ichiro Tsuji

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS　17　(12)　1290-1296　2010

    DOI： 10.5551/jat.5389 　

    ISSN： 1340-3478

    eISSN： 1880-3873

  276. What Psychosocial Characteristics are Associated with Smoking Cessation Behavior and Readiness to Quit Smoking Among Japanese Male Ever-Smokers with Type 2 Diabetes Mellitus

    Akiko Morimoto, Naomi Miyamatsu, Tomonori Okamura, Atsushi Hozawa, Aya Kadota, Miho Morinaga, Mihoko Ogita, Atsunori Kashiwagi, Hirotsugu Ueshima

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS　17　(4)　361-368　2010

    DOI： 10.5551/jat.3194 　

    ISSN： 1340-3478

    eISSN： 1880-3873

  277. γ-Glutamyltransferase and mortality risk from heart disease and stroke in Japanese men and women: NIPPON DATA90

    Akira Fujiyoshi, Katsuyuki Miura, Atsushi Hozawa, Yoshitaka Murakami, Naoyuki Takashima, Nagako Okuda, Takashi Kadowaki, Yoshikuni Kita, Tomonori Okamura, Yasuyuki Nakamura, Takehito Hayakawa, Akira Okayama, Hirotsugu Ueshima

    CVD Prevention and Control　5　(1)　27-34　2010/01

    DOI： 10.1016/j.cvdpc.2010.03.003 　

    ISSN： 1875-4570

  278. 要介護認定に対する基本チェックリストの予測妥当性の検証 大崎コホート2006研究

    遠又 靖丈, 寳澤 篤, 大森 芳, 永井 雅人, 菅原 由美, 新田 明美, 栗山 進一, 辻 一郎

    日本公衆衛生学会総会抄録集　68回　216-216　2009/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  279. 体格と生涯医療費の関連 大崎国保コホート研究

    永井 雅人, 栗山 進一, 柿崎 真沙子, 大森 芳, 寳澤 篤, 橋本 修二, 辻 一郎

    日本公衆衛生学会総会抄録集　68回　279-279　2009/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  280. 高齢者における血圧と要介護認定の関連 鶴ヶ谷コホート研究

    寳澤 篤, 栗山 進一, 大森 芳, 曽根 稔雅, 新田 明美, 菅原 由美, 中谷 直樹, 牛 凱軍, 粟田 主一, 辻 一郎

    日本高血圧学会総会プログラム・抄録集　32回　304-304　2009/10

    Publisher: (NPO)日本高血圧学会

  281. 体格が平均余命に及ぼす影響 大崎国保コホート研究

    永井 雅人, 栗山 進一, 寳澤 篤, 辻 一郎

    肥満研究　15　(Suppl.)　200-200　2009/09

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  282. High blood pressure in middle age is associated with a future decline in activities of daily living. NIPPON DATA80

    A. Hozawa, T. Okamura, Y. Murakami, T. Kadowaki, N. Okuda, N. Takashima, T. Hayakawa, Y. Kita, K. Miura, Y. Nakamura, A. Okayama, H. Ueshima

    JOURNAL OF HUMAN HYPERTENSION　23　(8)　546-552　2009/08

    DOI： 10.1038/jhh.2008.155 　

    ISSN： 0950-9240

    eISSN： 1476-5527

  283. Adult height and the risks of cardiovascular disease and major causes of death in the Asia-Pacific region: 21 000 deaths in 510 000 men and women

    Crystal Man Ying Lee, Federica Barzi, Mark Woodward, G. David Batty, Graham G. Giles, Jean Woo Wong, Konrad Jamrozik, Tai Hing Lam, Hirotsugu Ueshima, Hyeon Chang Kim, Dong Feng Gu, Mary Schooling, Rachel R. Huxley

    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY　38　(4)　1060-1071　2009/08

    DOI： 10.1093/ije/dyp150 　

    ISSN： 0300-5771

  284. Fish consumption and the risk of colorectal cancer: the Ohsaki Cohort Study

    Y. Sugawara, S. Kuriyama, M. Kakizaki, M. Nagai, K. Ohmori-Matsuda, T. Sone, A. Hozawa, Y. Nishino, I. Tsuji

    BRITISH JOURNAL OF CANCER　101　(5)　849-854　2009/08

    DOI： 10.1038/sj.bjc.6605217 　

    ISSN： 0007-0920

  285. 長寿フロントライン NIPPON DATA90の15年目の追跡調査による健康寿命及びADL、QOL低下に影響を与える要因の分析とNIPPON DATA80の19年追跡調査成績の分析

    寳澤 篤

    Aging & Health　18　(2)　38-41　2009/07

    Publisher: (公財)長寿科学振興財団

  286. 家庭血圧で測定された血圧の季節変動性についての検討

    寳澤 篤, 栗山 進一, 島津 太一, 大森 芳, 辻 一郎

    東北公衆衛生学会誌　(58)　20-20　2009/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  287. 境界域危険因子集積と循環器疾患死亡リスクとの関連 NIPPON DATA90,1990-2005

    氏門田 文, 三浦 克之, 寳澤 篤, 岡村 智教, 高嶋 直敬, 藤吉 朗, 早川 岳人, 村上 義孝, 喜多 義邦, 岡山 明, 中村 保幸, 上島 弘嗣

    日本循環器病予防学会誌　44　(2)　90-90　2009/04

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  288. 喫煙による循環器疾患の過剰死亡はメタボリックシンドロームより大きい NIPPON DATA90

    高嶋 直敬, 寳澤 篤, 門田 文, 三浦 克之, 岡村 智教, 中村 保幸, 早川 岳人, 奥田 奈賀子, 門脇 崇, 村上 義孝, 喜多 義邦, 岡山 明, 上島 弘嗣

    日本循環器病予防学会誌　44　(2)　92-92　2009/04

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  289. Elevated Serum gamma-Glutamyltransferase Was Associated with Cardiovascular Death in Japanese Women but Not in Men

    Akira Fujiyoshi, Atsushi Hozawa, Yoshitaka Murakami, Naoyuki Takashima, Nagako Okuda, Takashi Kadowaki, Yoshikuni Kita, Tomonori Okamura, Yasuyuki Nakamura, Takehito Hayakawa, Akira Okayama, Katsuyuki Miura, Hirotsugu Ueshima

    CIRCULATION　119　(10)　E313-E313　2009/03

    ISSN： 0009-7322

  290. 緑茶摂取頻度とK6得点との関連—大崎コホート2006研究—

    寳澤篤, 栗山進一, 中谷直樹, 大森芳, 柿崎真沙子, 曽根稔雅, 永井雅人, 新田明美, 菅原由美, 牛凱軍, 辻一郎

    J Epidemiol　19　(1 Supplement)　210　2009/01/24

    ISSN： 0917-5040

  291. 性別にみたBMIと死因別死亡リスクに関する前向きコホート研究—大崎国保コホート研究—

    永井雅人, 柿崎真沙子, 栗山進一, 大森芳, 菅原由美, 曽根稔雅, 寳澤篤, 辻一郎

    J Epidemiol　19　(1 Supplement)　76　2009/01/24

    ISSN： 0917-5040

  292. Motor Fitness Scaleと要介護発生・死亡リスクに関する前向きコホート研究—鶴ケ谷プロジェクト—

    星真行, 星真行, 寳澤篤, 栗山進一, 中谷直樹, 大森芳, 曽根稔雅, 柿崎真沙子, 牛凱軍, 藤田和樹, 植木章三, 芳賀博, 永富良一, 辻一郎

    J Epidemiol　19　(1 Supplement)　198　2009/01/24

    ISSN： 0917-5040

  293. 魚摂取と大腸がん罹患リスクに関する前向きコホート研究:大崎国保コホート研究

    菅原由美, 柿崎真沙子, 栗山進一, 大森芳, 曽根稔雅, 寳澤篤, 西野善一, 辻一郎

    J Epidemiol　19　(1 Supplement)　63　2009/01/24

    ISSN： 0917-5040

  294. 睡眠時間と乳がん罹患リスクに関する前向きコホート研究:大崎国保コホート研究

    柿崎真沙子, 柿崎真沙子, 栗山進一, 曽根稔雅, 大森芳, 寳澤篤, 中谷直樹, 福土審, 辻一郎

    J Epidemiol　19　(1 Supplement)　67　2009/01/24

    ISSN： 0917-5040

  295. 末梢動脈疾患と要介護発生に関する前向きコホート研究〜鶴ケ谷プロジェクト〜

    新田明美, 新田明美, 寳澤篤, 栗山進一, 中谷直樹, 大森芳, 曽根稔雅, 柿崎真沙子, 海老原覚, 市来正隆, 荒井啓行, 辻一郎

    J Epidemiol　19　(1 Supplement)　199　2009/01/24

    ISSN： 0917-5040

  296. IMPACT OF NOCTURIA ON MEDICAL CARE USE AND ITS COSTS IN AN ELDERLY POPULATION: 30 MONTH PROSPECTIVE OBSERVATION OF NATIONAL HEALTH INSURANCE BENEFICIARIES IN JAPAN

    H. Nakagawa, Y. Ikeda, Y. Kaiho, M. Matsushita, A. Hozawa, K. Ohmori-Matsuda, Tsuji, I, Y. Arai

    NEUROUROLOGY AND URODYNAMICS　28　(7)　930-931　2009

    ISSN： 0733-2467

  297. 高齢者の医療費・入院日数と夜間頻尿との関連 国民健康保険からの前向き調査

    中川晴夫, 海法康裕, 池田義弘, 寶澤篤, 松下真史, 川守田直樹, 辻一郎, 荒井陽一

    日本排尿機能学会誌　20　(1)　197-197　2009

  298. 食生活・栄養素摂取状況が高齢者の健康寿命に与える影響に関する研究:NIPPON DATA80・90の追跡調査 喫煙による循環器疾患の過剰死亡はメタボリックシンドロームより大きい‐NIPPON DATA90‐

    高嶋直敬, 三浦克之, 寳澤篤, 門田文, 岡村智教, 中村保幸, 早川岳人, 奥田奈賀子, 藤吉朗, 門脇崇, 村上義孝, 喜多義邦, 岡山明, 上島弘嗣

    食生活・栄養素摂取状況が高齢者の健康寿命に与える影響に関する研究:NIPPON DATA80・90の追跡調査 平成20年度 総括・分担研究報告書　218-223　2009

  299. 食生活・栄養素摂取状況が高齢者の健康寿命に与える影響に関する研究:NIPPON DATA80・90の追跡調査 中年期の血圧高値と将来のADL低下についての検討―NIPPON DATA80―

    寳澤篤, 岡村智教, 村上義孝, 門脇崇, 奥田奈賀子, 高嶋直敬, 早川岳人, 喜多義邦, 三浦克之, 中村保幸, 岡山明, 上島弘嗣

    食生活・栄養素摂取状況が高齢者の健康寿命に与える影響に関する研究:NIPPON DATA80・90の追跡調査 平成20年度 総括・分担研究報告書　18-32　2009

  300. 食生活・栄養素摂取状況が高齢者の健康寿命に与える影響に関する研究:NIPPON DATA80・90の追跡調査 中年期の喫煙と将来のADL,IADLの低下とのリスクについて

    高嶋直敬, 寳澤篤, 岡村智教, 三浦克之, 早川岳人, 奥田奈賀子, 門脇崇, 村上義孝, 喜多義邦, 中村保幸, 岡山明, 上島弘嗣

    食生活・栄養素摂取状況が高齢者の健康寿命に与える影響に関する研究:NIPPON DATA80・90の追跡調査 平成20年度 総括・分担研究報告書　33-39　2009

  301. 食生活・栄養素摂取状況が高齢者の健康寿命に与える影響に関する研究:NIPPON DATA80・90の追跡調査 中年期の食事習慣と将来の日常生活活動(ADL)変化―NIPPON DATA80研究結果

    中村保幸, 寳澤篤, TURIN Tanvir C, 高嶋直敬, 岡村智教, 早川岳人, 喜多義邦, 岡山明, 三浦克之, 上島弘嗣

    食生活・栄養素摂取状況が高齢者の健康寿命に与える影響に関する研究:NIPPON DATA80・90の追跡調査 平成20年度 総括・分担研究報告書　40-50　2009

  302. JNC7分類における高血圧分類と循環器疾患死亡の関連 大崎国保コホート

    寳澤 篤, 栗山 進一, 大森 芳, 大久保 孝義, 辻 一郎

    日本高血圧学会総会プログラム・抄録集　31回　322-322　2008/10

    Publisher: (NPO)日本高血圧学会

  303. 滋賀県甲賀市国保加入者の健診未受診者の実態について

    田口 真理, 門脇 紗也佳, 寳澤 篤, 岡村 智教, 上島 弘嗣

    日本公衆衛生学会総会抄録集　67回　350-350　2008/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  304. 健診受診と死亡リスクの関連 大崎国保コホート

    寳澤 篤, 栗山 進一, 柿崎 真沙子, 大森 芳, 大久保 孝義, 辻 一郎

    日本公衆衛生学会総会抄録集　67回　411-411　2008/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  305. 要介護認定者における要介護状態区分の推移に関する研究

    曽根 稔雅, 中谷 直樹, 大森 芳, 寳澤 篤, 栗山 進一, 辻 一郎

    日本公衆衛生学会総会抄録集　67回　519-519　2008/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  306. Sleep duration and the risk of breast cancer: the Ohsaki Cohort Study

    M. Kakizaki, S. Kuriyama, T. Sone, K. Ohmori-Matsuda, A. Hozawa, N. Nakaya, S. Fukudo, I. Tsuji

    BRITISH JOURNAL OF CANCER　99　(9)　1502-1505　2008/10

    DOI： 10.1038/sj.bjc.6604684 　

    ISSN： 0007-0920

  307. 高齢者の過活動膀胱に対するリスクファクターの検討

    池田 義弘, 佐竹 洋平, 浪間 孝重, 大沼 徹太郎, 中川 晴夫, 荒井 陽一, 大森 芳, 寶澤 篤, 辻 一郎

    日本排尿機能学会誌　19　(1)　114-114　2008/09

    Publisher: (一社)日本排尿機能学会

    ISSN： 1347-6513

  308. 高齢者の尿失禁と身体活動量との関連

    中川 晴夫, 牛 凱軍, 池田 義弘, 寶澤 篤, 大森 芳, 今西 里佳, 海法 康裕, 永富 良一, 辻 一郎, 荒井 陽一

    日本排尿機能学会誌　19　(1)　87-87　2008/09

    Publisher: (一社)日本排尿機能学会

    ISSN： 1347-6513

  309. 年齢階級別のBMIと全死因死亡リスクを検討した前向きコホート研究

    永井 雅人, 栗山 進一, 寳澤 篤, 辻 一郎

    肥満研究　14　(Suppl.)　139-139　2008/09

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  310. 低栄養と介護保険認定・死亡リスクに関するコホート研究 鶴ヶ谷プロジェクト

    東口 みづか, 中谷 直樹, 大森 芳, 島津 太一, 曽根 稔雅, 寳澤 篤, 栗山 進一, 辻 一郎

    日本公衆衛生雑誌　55　(7)　433-439　2008/07

    Publisher: 日本公衆衛生学会

    DOI： 10.11236/jph.55.7_433 　

    ISSN： 0546-1766

  311. 肥満度の変化と冠動脈石灰化との関連

    門脇 崇, Sekikawa Akira, 門脇 紗也佳, 寳澤 篤, 奥田 奈賀子, 高嶋 直敬, 門田 文, 家門 裕子, 藤吉 朗, 岡村 智教, 中村 保幸, 村上 義孝, 喜多 義邦, 三浦 克之, 上島 弘嗣

    日本循環器病予防学会誌　43　(1)　37-37　2008/04

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  312. 厳密に測定された診察室血圧値は家庭血圧値よりも高値か?

    寳澤 篤, 門脇 崇, 三浦 克之, 門脇 紗也佳, 門田 文, 高嶋 直敬, 奥田 奈賀子, 村上 義孝, 喜多 義邦, 岡村 智教, 関川 暁, 上島 弘嗣

    日本循環器病予防学会誌　43　(1)　39-39　2008/04

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  313. 若年成人男性における婚姻状況の変化と循環器疾患危険因子の変化との関連の検討 HIPOP-OHP研究

    藤吉 朗, 寳澤 篤, 三浦 克之, 岡村 智教, 田中 太一郎, 村上 義孝, 家門 裕子, 門脇 崇, 岡山 明, 上島 弘嗣

    日本循環器病予防学会誌　43　(1)　48-48　2008/04

    Publisher: (一社)日本循環器病予防学会

    ISSN： 1346-6267

  314. HbA1Cおよび随時血糖値と全循環器疾患死亡の関連 NIPPON DATA90、1990-2000

    門田 文, 岡村 智教, 寳澤 篤, 門脇 崇, 早川 岳人, 喜多 義邦, 斉藤 重幸, 前川 聡, 岡山 明, 中村 保幸, 柏木 厚典, 上島 弘嗣

    糖尿病　51　(Suppl.1)　S-192　2008/04

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

  315. Relationship of elevated casual blood glucose level with coronary heart disease, cardiovascular disease and all-cause mortality in a representative sample of the Japanese population. NIPPON DATA80

    S. Kadowaki, T. Okamura, A. Hozawa, T. Kadowaki, A. Kadota, Y. Murakami, K. Nakamura, S. Saitoh, Y. Nakamura, T. Hayakawa, Y. Kita, A. Okayama, H. Ueshima

    DIABETOLOGIA　51　(4)　575-582　2008/04

    DOI： 10.1007/s00125-007-0915-6 　

    ISSN： 0012-186X

  316. OE-090 Should Alcohol Intake be Restricted in Diabetic Men? : NIPPON DATA80(Preventive medicine/Epidemiology/Education(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

    Nakamura Yasuyuki, Ueshima Hirotsugu, Kadota Aya, Hozawa Atsushi, Okamura Tomonori, Kadowaki Sayaka, Kadowaki Takashi, Hayakawa Takehito, Kita Yoshikuni, Abbott Robert, Okayama Akira

    Circulation journal : official journal of the Japanese Circulation Society　72　202-202　2008/03/01

    Publisher: Japanese Circulation Society

    ISSN： 1346-9843

  317. 【脂質異常症 新ガイドラインと治療戦略】 ガイドラインを支える疫学研究 コレステロールと脳卒中

    寳澤 篤, 上島 弘嗣

    最新医学　63　(2)　180-185　2008/02

    Publisher: (株)最新医学社

    ISSN： 0370-8241

  318. 高感度C反応性蛋白レベルと介護保険認定・死亡リスクに関する前向きコホート研究:鶴ケ谷プロジェクト

    曽根稔雅, 牛凱軍, 中谷直樹, 大森芳, 東口みづか, 柿崎真沙子, 寳澤篤, 栗山進一, 辻一郎

    J Epidemiol　18　(1 Supplement)　122　2008/01/25

    ISSN： 0917-5040

  319. 24時間尿中Na排泄量により分類した高食塩摂取者と低食塩摂取者の食事パターンINTERMAP Japanより

    奥田奈賀子, 寶澤篤, 高嶋直敬, 村上義孝, 門脇崇, 上島弘嗣, 由田克士, 斎藤重幸, 坂田清美, 三浦克之, 中川秀昭, 岡山明

    J Epidemiol　18　(1 Supplement)　219　2008/01/25

    ISSN： 0917-5040

  320. 中壮年期の高血圧は将来のADL低下を予測するか―NIPPON DATA80―

    寳澤篤, 村上義孝, 門脇崇, 奥田奈賀子, 高嶋直敬, 喜多義邦, 上島弘嗣, 岡村智教, 早川岳人, 中村保幸, 岡山明

    J Epidemiol　18　(1 Supplement)　147　2008/01/25

    ISSN： 0917-5040

  321. 高齢者の尿失禁は骨折の、夜間頻尿は3年以内生存率低下のリスクファクターである 疫学調査後の3年間の経過観察による検討

    中川晴夫, 池田義弘, 海法康裕, 大森芳, 寶澤篤, 辻一郎, 荒井陽一

    日本泌尿器科学会雑誌　99　(2)　246-246　2008

    Publisher: 一般社団法人 日本泌尿器科学会

    DOI： 10.5980/jpnjurol.99.246_2 　

  322. 高齢者の失禁と身体活動量との関連について

    中川 晴夫, 牛 凱軍, 池田 義弘, 菊池 章夫, 大森 芳, 今西 里佳, 寶澤 篤, 永富 良一, 辻 一郎, 荒井 陽一

    日本ストーマ・排泄リハビリテーション学会誌　24　(1)　92-92　2008/01

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

  323. 食生活・栄養素摂取状況が高齢者の健康寿命に与える影響に関する研究 第1章 ADLおよび健康寿命に関する研究 NIPPON DATA80,NIPPON DATA90の追跡調査によるADL低下に影響を与える要因の解明及び危険因子が健康寿命に与える影響

    上島弘嗣, 岡村智教, 三浦克之, 早川岳人, 村上義孝, 寳澤篤, 高嶋直敬, 角野文彦

    食生活・栄養素摂取状況が高齢者の健康寿命に与える影響に関する研究:NIPPON DATA80・90の追跡調査 平成19年度 研究報告書　7-14　2008

  324. わが国における飲酒の実態と飲酒に関連する生活習慣病,公衆衛生上の諸問題とその対策に関する研究

    上島弘嗣, 岡村智教, 門脇崇, 寳澤篤, 高嶋直敬

    わが国における飲酒の実態ならびに飲酒に関連する生活習慣病、公衆衛生上の諸問題とその対策に関する総合的研究 平成19年度 総括研究報告書　117-120　2008

  325. 血清ＨＤＬコレステロールと日常生活動作、総死亡の関連 -1990年循環器疾患基礎調査受検者の10年間の追跡調査から（ＮＩＰＰＯＮ ＤＡＴＡ90）-

    岡村 智教, 東山 綾, 寳澤 篤, 高嶋 直敬, 奥田 奈賀子, 村上 義孝, 門脇 崇, 喜多 義邦, 上島 弘嗣, 早川 岳人, 岡山 明, for the NIPPON DATA, Research group

    J Epidemiol　18　(1)　69-69　2008

  326. 60歳以降の男性における喫煙経験別にみた傷害なし平均余命 -NIPPON DATA90 による健康寿命の算定ー

    村上 義孝, 寳澤 篤, 岡村 智教, 高嶋 直敬, 奥田 奈賀子, 喜多 義邦, 門脇 崇, 上島 弘嗣, 早川 岳人, 岡山 明, for the NIPPON DATA, Research Group

    J Epidemiol　18　(1)　70-70　2008

  327. 中壮年期の喫煙行動と老年期の日常生活動作、総死亡の関連 -1980年循環器疾患基礎調査受検者の19年の追跡調査から（NIPPON DATA80)-

    高嶋 直敬, 寳澤 篤, 奥田 奈賀子, 村上 義孝, 門脇 崇, 喜多 義邦, 上島 弘嗣, 岡村 智教, 早川 岳人, 中村 保幸, 岡山 明, for the NIPPON DATA, Research Group

    J Epidemiol　18　(1)　145-145　2008

  328. 血清γ-ＧＴＰ活性と総死亡との関連 -NIPPON DATA 90による検討-

    藤吉 朗, 寳澤 篤, 村上 義孝, 門脇 崇, 高嶋 直敬, 奥田 奈賀子, 喜多 義邦, 上島 弘嗣, 岡村 智教, 中村 保幸, 早川 岳人, 岡山 明

    J Epidemiol　18　(1)　146-146　2008

  329. 高齢者での低レベルの血清CRP濃度と体力低下との関連

    牛 凱軍, 寳澤 篤, 郭 輝, 栗山 進一, 楊 光, 大森 芳, 中谷 直樹, 高橋 英子, 藤田 和樹, 辻 一郎, 永富 良一

    体力科学　56　(6)　806-806　2007/12

    Publisher: (一社)日本体力医学会

    ISSN： 0039-906X

    eISSN： 1881-4751

  330. 人間ドックの費用対効果 なにがいくらでどこまでできるか 基本健康診査成績と医療費との関連 大崎国保コホート研究から

    辻 一郎, 大森 芳, 島津 太一, 寳澤 篤, 栗山 進一

    日本医学会総会会誌　27回　(学術講演要旨)　140-140　2007/12

    Publisher: 日本医学会

  331. γ-Glutamyltransferase predicts cardiovascular death among Japanese women

    Atsushi Hozawa, Tomonori Okamura, Takashi Kadowaki, Yoshitaka Murakami, Koshi Nakamura, Takehito Hayakawa, Yoshikuni Kita, Yasuyuki Nakamura, Akira Okayama, Hirotsugu Ueshima

    Atherosclerosis　194　(2)　498-504　2007/10

    DOI： 10.1016/j.atherosclerosis.2006.08.058 　

    ISSN： 0021-9150

  332. 危険因子 脂質異常症 性差

    寳澤 篤, 門田 文, 上島 弘嗣

    動脈硬化予防　6　(3)　98-99　2007/10

    Publisher: (株)メジカルビュー社

    ISSN： 1347-7056

  333. 中壮年期男性では高血圧と喫煙により約60%の循環器疾患死亡が説明される。NIPPON DATA80

    寳澤 篤, 岡村 智教, 村上 義孝, 門脇 崇, 中村 幸志, 早川 岳人, 喜多 義邦, 中村 保幸, アボット・ロバート, 岡山 明, 上島 弘嗣

    日本高血圧学会総会プログラム・抄録集　30回　152-152　2007/10

    Publisher: (NPO)日本高血圧学会

  334. NIPPON DATA80における血清アルブミン、コレステロールと日常生活動作・死亡の関連

    岡村 智教, 早川 岳人, 門脇 崇, 寳澤 篤, 村上 義孝, 喜多 義邦, 岡山 明, 上島 弘嗣

    日本公衆衛生学会総会抄録集　66回　483-483　2007/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  335. アルコール摂取量・GGT値と糖尿病発症の関連 HIPOP-OHP研究、平均3.4年の追跡調査より

    寳澤 篤, 岡村 智教, 田中 太一郎, 菊池 有利子, 由田 克士, 武林 亨, 門脇 崇, 岡山 明, 上島 弘嗣

    日本アルコール・薬物医学会雑誌　42　(4)　338-339　2007/08

    Publisher: 日本アルコール・アディクション医学会

    ISSN： 1341-8963

  336. 40歳代および60歳代男性の中等度飲酒の潜在性動脈硬化予防効果

    門脇 崇, 岡村 智教, 宮松 直美, 寳澤 篤, 喜多 義邦, 上島 弘嗣

    日本アルコール・薬物医学会雑誌　42　(4)　352-353　2007/08

    Publisher: 日本アルコール・アディクション医学会

    ISSN： 1341-8963

  337. 危険因子の集積と循環器疾患死亡の関連 NIPPON DATA90,1990-2000

    門田 文, 寳澤 篤, 岡村 智教, 門脇 崇, 早川 岳人, 喜多 義邦, 岡山 明, 前川 聡, 中村 保幸, 柏木 厚典, 上島 弘嗣

    糖尿病　50　(Suppl.1)　S-193　2007/04

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

  338. 在宅高齢女性集団における身体活動と尿失禁との関連 鶴ヶ谷プロジェクト

    菊池 章夫, 郭 輝, 牛 凱軍, 池田 義弘, 寶沢 篤, 中川 晴夫, 大森 芳, 辻 一郎, 永富 良一

    運動疫学研究: Research in Exercise Epidemiology　9　23-23　2007/03

    Publisher: 日本運動疫学会

    ISSN： 1347-5827

  339. 在宅高齢者の余暇身体活動量と医療費の関連 鶴ヶ谷プロジェクト

    楊 光, 牛 凱軍, 藤田 和樹, 寶澤 篤, 大森 芳, 辻 一郎, 永富 良一

    運動疫学研究: Research in Exercise Epidemiology　9　24-24　2007/03

    Publisher: 日本運動疫学会

    ISSN： 1347-5827

  340. Validity and utility of the Japanese version of the WHO-Five Well-Being Index in the context of detecting suicidal ideation in elderly community residents

    S. Awata, P. Bech, Y. Koizum, T. Seki, S. Kuriyama, A. Hozawa, K. Ohmori, N. Nakaya, H. Matsuoka, I. Tsuji

    INTERNATIONAL PSYCHOGERIATRICS　19　(1)　77-88　2007/02

    DOI： 10.1017/S1041610206004212 　

    ISSN： 1041-6102

  341. 自己申告高血圧の循環器疾患死亡予測における有用性

    東山綾, 寳澤篤, 上島弘嗣

    血圧　14　(9)　870-871　2007

  342. アルコール摂取頻度別の血圧と循環器死亡リスクーNIPPON DATA90-

    高嶋直敬, Sohel Reza Choudhury, 寳澤篤, 岡村智教, 門脇崇, 村上義孝, 中村幸志, 奥田奈賀子, 喜多義邦, 早川岳人, 中村保幸, 岡山明, 上島弘嗣, NIPPON DATA, Research Group

    第３０回日本高血圧学会抄録集　-　(-)　192--　2007

  343. 【脳卒中の病型と危険因子】 コレステロールは日本人の脳卒中を予測するか?

    寳澤 篤, 岡村 智教

    動脈硬化予防　5　(4)　43-47　2007/01

    Publisher: (株)メジカルビュー社

    ISSN： 1347-7056

  344. Introversion associated with large differences between screening blood pressure and home blood pressure measurement the ohasama study Peer-reviewed

    Atsushi Hozawa, Takayoshi Ohkubo, Taku Obara, Hirohito Metoki, Masahiro Kikuya, Kei Asayama, Kazuhito Totsune, Junichiro Hashimoto, Haruhisa Hoshi, Yumiko Arais, Hiroshi Satoh, Toru Hosokawa, Yutaka Imai

    JOURNAL OF HYPERTENSION　24　211-211　2006/12

    ISSN： 0263-6352

  345. 日本の地域社会の高齢者女性集団における余暇時身体活動と尿失禁との関連 鶴ヶ谷プロジェクト

    菊池 章夫, 牛 凱軍, 寳澤 篤, 池田 義弘, 中川 晴夫, 郭 輝, 大森 芳, 辻 一郎, 永富 良一

    体力科学　55　(6)　896-896　2006/12

    Publisher: (一社)日本体力医学会

    ISSN： 0039-906X

  346. The effect of modifiable risk factors on pancreatic cancer mortality in populations of the Asia-Pacific region

    Alireza Ansary-Moghaddam, Rachel Huxley, Federica Barzi, Carlene Lawes, Takayoshi Ohkubo, Xianghua Fang, Sun Ha Jee, Mark Woodward

    CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION　15　(12)　2435-2440　2006/12

    DOI： 10.1158/1055-9965.EPI-06-0368 　

    ISSN： 1055-9965

  347. 家庭血圧測定の意義 (血圧)

    寳澤 篤, 辻 一郎

    血圧　13　(11)　1174-1175　2006/11

  348. Introversion associated with large differences between screening blood pressure and home blood pressure measurement: the Ohasama study

    Atsushi Hozawa, Takayoshi Ohkubo, Taku Obara, Hirohito Metoki, Masahiro Kikuya, Kei Asayama, Kazuhito Totsune, Junichiro Hashimoto, Haruhisa Hoshi, Yumiko Arai, Hiroshi Satoh, Toru Hosokawa, Yutaka Imai

    JOURNAL OF HYPERTENSION　24　(11)　2183-2189　2006/11

    DOI： 10.1097/01.hjh.0000249695.81241.35 　

    ISSN： 0263-6352

  349. 日本人高齢者におけるC反応性蛋白と下肢閉塞性動脈硬化症の関連 (Arterial Stiffness)

    寳澤篤, 大森芳, 栗山進一, 島津太一, 牛凱軍, 渡戸亜矢, 海老原覚, 松井敏史, 市来正隆, 永富良一, 佐々木英忠, 辻一郎

    Arterial Stiffness　64-65　2006/10

  350. Does the impact of smoking on coronary heart disease differ by low-density lipoprotein cholesterol level? - The atherosclerosis risk in communities (ARIC) study

    Atsushi Hozawa, Aaron R. Folsom, A. Richey Sharrett, Thomas J. Payne, Lloyd E. Chambless

    CIRCULATION JOURNAL　70　(9)　1105-1110　2006/09

    DOI： 10.1253/circj.70.1105 　

    ISSN： 1346-9843

  351. Serum uric acid and risk of ischemic stroke: The ARIC Study

    Atsushi Hozawa, Aaron R. Folsom, Hassan Ibrahim, F. Javier Nieto, Wayne D. Rosamond, Eyal Shahar

    ATHEROSCLEROSIS　187　(2)　401-407　2006/08

    DOI： 10.1016/j.atherosclerosis.2005.09.020 　

    ISSN： 0021-9150

  352. Passive smoke exposure and carotenoid levels in the cardia study.

    R. Widome, D. R. Jacobs, A. Hozawa, P. J. Schreiner, C. Iribarren, M. Gross

    AMERICAN JOURNAL OF EPIDEMIOLOGY　163　(11)　S4-S4　2006/06

    ISSN： 0002-9262

  353. Benefit of home blood pressure measurement after a finding of high blood pressure at a community screening

    Atsushi Hozawa, Taichi Shimazu, Shinichi Kuriyama, Ichiro Tsuji

    Journal of Hypertension　24　(7)　1265-1271　2006/06

    DOI： 10.1097/01.hjh.0000234105.23615.95 　

    ISSN： 0263-6352

  354. Associations of serum carotenoid concentrations with the development of diabetes and with insulin concentration: Interaction with smoking - The Coronary Artery Risk Development in Young Adults (CARDIA) Study

    A Hozawa, DR Jacobs, MW Steffes, MD Gross, LM Steffen, DH Lee

    AMERICAN JOURNAL OF EPIDEMIOLOGY　163　(10)　929-937　2006/05

    DOI： 10.1093/aje/kwj136 　

    ISSN： 0002-9262

  355. The association of cigarette smoking with self-reported disease before middle age: The Coronary Artery Risk Development in Young Adults (CARDIA) study

    A Hozawa, T Houston, MW Steffes, R Widome, OD Williams, C Inibarren, MJ Pletcher, ML Daviglus, JJ Carr, DR Jacobs

    PREVENTIVE MEDICINE　42　(3)　193-199　2006/03

    DOI： 10.1016/j.ypmed.2005.12.008 　

    ISSN： 0091-7435

  356. Favorable risk factor profile and cardiovascular disease incidence among African Americans versus whites: The Atherosclerosis Risk in Communities Study

    A Hozawa, AR Folsom, RA Sharrett, LE Chambless

    CIRCULATION　113　(8)　E377-E378　2006/02

    ISSN： 0009-7322

  357. 適正減量を目指した糖尿病予防の個別健康教育における強力介入群と通常介入群の比較

    栗山 進一, 島津 太一, 寳澤 篤, 矢部 美津子, 田崎 美記子, 物永 葉子, 境 道子, 三浦 千早, 伊藤 文枝, 伊藤 孝子, 矢部 初枝, 新田 幸恵, 鈴木 玲子, 藤田 和樹, 永富 良一, 辻 一郎

    日本公衆衛生雑誌　53　(2)　122-132　2006/02

    Publisher: 日本公衆衛生学会

    DOI： 10.11236/jph.53.2_122 　

    ISSN： 0546-1766

    eISSN： 2187-8986

  358. White-coat hypertension and progression to home hypertension

    Takashi Ugajin, Atsushi Hozawa, Takayoshi Ohkubo, Takayoshi Ohkubo, Kei Asayama, Kei Asayama, Masahiro Kikuya, Taku Obara, Hirohito Metoki, Hirohito Metoki, Haruhisa Hoshi, Junichiro Hashimoto, Junichiro Hashimoto, Kazuhito Totsune, Kazuhito Totsune, Hiroshi Satoh, Hiroshi Satoh, Ichiro Tsuji, Yutaka Imai, Yutaka Imai

    Cardiology Review　23　18-22　2006/02/01

    ISSN： 1092-6607

  359. 高齢者の排尿機能に関する検討〜GDSを用いたうつ傾向との関連を中心として

    池田義弘, 中川晴夫, 竹本淳, 海法康裕, 大森芳, 寶澤篤, 小泉弥生, 西野善一, 栗山進一, 辻一郎, 荒井陽一

    日本泌尿器科学会雑誌　97　(2)　264-264　2006

  360. Association between depressive symptoms and cerebrovascular lesions on MRI in community-dwelling elderly individuals

    Toru Seki, Shuichi Awata, Yayoi Koizumi, Shigeo Kinomura, Yasuyuki Taki, Atsushi Hozawa, Kaori Ohmori, Shinichi Kuriyama, Hiroshi Fukuda, Ichiro Tsuji

    Japanese Journal of Geriatrics　43　(1)　102-107　2006

    Publisher: Japan Geriatrics Society

    DOI： 10.3143/geriatrics.43.102 　

    ISSN： 0300-9173

  361. 日本の地域社会の高齢者におけるC-反応性蛋白と高血圧の関連に及ぼす余暇の身体的活動の影響 Tsurugayaプロジェクト(Influence of Leisure-Time Physical Activity on the Relationship between C-reactive protein and Hypertension in a Community-Based Elderly Population of Japan: The Tsurugaya Project)

    牛 凱軍, 寶澤 篤, 藤田 和樹, 奥津 光晴, 栗山 進一, 辻 一郎, 永富 良一

    体力科学　54　(6)　654-654　2005/12

    Publisher: (一社)日本体力医学会

    ISSN： 0039-906X

    eISSN： 1881-4751

  362. 治療過程への患者の主体的参加の有効性評価 家庭血圧を用いた健診高血圧未治療者に対する介入研究

    寳澤 篤

    上原記念生命科学財団研究報告集　19　113-115　2005/12

    Publisher: (公財)上原記念生命科学財団

  363. Does sex matter in the associations between classic risk factors and fatal coronary heart disease in populations from the Asia-Pacific region?

    R Huxley, M Woodward, F Barzi, JW Wong, WH Pan, A Patel, D Gu, TH Lam, C Lawes, S MacMahon, A Rodgers, Suh, I, H Ueshima, Parag, V, A Okayama, H Maegawa, N Aoki, M Nakamura, N Kubo, T Yamada, ZS Wu, CH Yao, ZS Wu, G Andrews, TA Welborn, Z Tang, LS Liu, JX Xie, R Norton, S Ameratunga, S MacMahon, G Whitlock, MW Knuiman, H Christensen, J Zhou, XH Yu, XG Wu, A Tamakoshi, WH Pan, P Sritara, ZL Wu, LQ Chen, GL Shan, DF Gu, XF Duan, R Norton, R Jackson, YH Li, TH Lam, CQ Jiang, M Fujishima, Y Kiyohara, H Iwamoto, J Woo, SC Ho, Z Hong, MS Huang, B Zhou, JL Fuh, H Ueshima, Y Kita, Choudhury, SR, Suh, I, SH Jee, IS Kim, G Giles, T Hashimoto, K Sakata, A Dobson, Y Imai, T Ohkubo, A Hozawa, K Jamrozik, P Norman, M Hobbs, R Broadhurst, K Nakachi, XH Fang, SC Li, QD Yang, ZM Chen, H Tanaka, Y Kita, A Nozaki, H Horibe, Y Matsutani, M Kagaya, K Hughes, J Lee, D Heng, SK Chew, BF Zhou, HY Zhang, K Shimamoto, S Saitoh, ZZ Li, Y He, TH Lam, SX Yao

    JOURNAL OF WOMENS HEALTH　14　(9)　820-828　2005/11

    DOI： 10.1089/jwh.2005.14.820 　

    ISSN： 1540-9996

  364. Smoking, quitting, and the risk of cardiovascular disease among women and men in the Asia-Pacific region

    M Woodward, TH Lam, F Barzi, A Patel, D Gu, A Rodgers, Suh, I, DF Gu, CMM Lawes, SW MacMahon, WH Pan, H Ueshima, Parag, V, A Okayama, H Maegawa, N Aoki, M Nakamura, N Kubo, T Yamada, ZS Wu, CH Yao, G Andrews, TA Welborn, Z Tang, LS Liu, JX Xie, R Norton, S Ameratunga, S MacMahon, G Whitlock, MW Knuiman, H Christensen, XG Wu, J Zhou, XH Yu, A Tamakoshi, WH Pan, ZL Wu, LQ Chen, GL Shan, P Sritara, DF Gu, XF Duan, R Norton, G Whitlock, R Jackson, YH Li, TH Lam, CQ Jiang, M Fujishima, Y Kiyohara, H Iwamoto, J Woo, SC Ho, Z Hong, MS Huang, B Zhou, JL Fuh, H Ueshima, Y Kita, Choudhury, SR, Suh, I, SH Jee, IS Kim, G Giles, T Hashimoto, K Sakata, A Dobson, Y Imai, T Ohkubo, A Hozawa, K Jamrozik, M Hobbs, R Broadhurst, K Nakachi, XH Fang, SC Li, QD Yang, ZM Chen, H Tanaka, Y Kita, A Nozaki, H Ueshima, H Horibe, Y Matsutani, M Kagaya, K Hughes, J Lee, D Heng, SK Chew, BF Zhou, HY Zhang, K Shimamoto, S Saitoh, ZZ Li, HY Zhang, P Norman, K Jamrozik, Y He, TH Lam, SX Yao

    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY　34　(5)　1036-1045　2005/10

    DOI： 10.1093/ije/dyi104 　

    ISSN： 0300-5771

  365. レセプト全傷病登録による糖尿病の合併症の医療費分析

    鈴木 寿則, 坪野 吉孝, 栗山 進一, 寳澤 篤, 大森 芳, 遠藤 彰, 辻 一郎

    日本公衆衛生雑誌　52　(7)　652-663　2005/07

    Publisher: 日本公衆衛生学会

    DOI： 10.11236/jph.52.7_652 　

    ISSN： 0546-1766

  366. 緑茶摂取と認知機能に関する横断研究 鶴ヶ谷寝たきり予防健診

    栗山 進一, 寳澤 篤, 大森 芳, 島津 太一, 松井 敏史, 海老原 覚, 粟田 主一, 永富 良一, 荒井 啓行, 辻 一郎

    日本老年医学会雑誌　42　(Suppl.)　93-93　2005/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  367. Serum uric acid and risk of ischemic stroke: The Atherosclerosis Risk in Communities (ARIC) Study

    A Hozawa, AR Folsom, H Ibrahim, JF Nieto, W Rosamond, E Shahar

    CIRCULATION　111　(14)　E238-E238　2005/04

    ISSN： 0009-7322

  368. Alcohol consumption and the risk of cancer in Japanese men: the Miyagi cohort study

    N Nakaya, Y Tsubono, S Kuriyama, A Hozawa, T Shimazu, K Kurashima, S Fukudo, D Shibuya, Tsuji, I

    EUROPEAN JOURNAL OF CANCER PREVENTION　14　(2)　169-174　2005/04

    DOI： 10.1097/00008469-200504000-00013 　

    ISSN： 0959-8278

  369. Association between social support and depression status in the elderly: Results of a one-year community-based prospective cohort study in Japan

    Y Koizumi, S Kuriyama, T Seki, K Ohmori, A Hozawa, Tsuji, I, H Matsuoka, S Awata

    INTERNATIONAL PSYCHOGERIATRICS　17　355-355　2005

    ISSN： 1041-6102

  370. Effects of a comprehensive community intervention model to reduce late-life depression and suicidal ideation in an urban residential district

    S Awata, T Seki, Y Koizumi, H Matsuoka, H Arai, R Nagatomi, A Hozawa, K Omori, S Kuriyama, Tsuji, I

    INTERNATIONAL PSYCHOGERIATRICS　17　381-382　2005

    ISSN： 1041-6102

  371. 高齢者における歯の保有状況と全身機能との関係

    菊池 雅彦, 高津 匡樹, 坪井 明人, 伊藤 進太郎, 佐藤 智昭, 舩山 恭子, 岩松 正明, 土谷 昌広, 小牧 健一朗, 秋葉 陽介, 大井 孝, 服部 佳功, 玉澤 佳純, 寶澤 篤, 辻 一郎, 渡辺 誠

    東北大学歯学雑誌　23　(2)　89-89　2004/12

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  372. C-reactive protein and peripheral artery disease among Japanese elderly: The Tsurugaya project

    A Hozawa, K Ohmori, S Kuriyama, T Shimazu, K Niu, A Watando, S Ebihara, T Matsui, M Ichiki, R Nagatomi, H Sasaki, Tsuji, I

    HYPERTENSION RESEARCH　27　(12)　955-961　2004/12

    DOI： 10.1291/hypres.27.955 　

    ISSN： 0916-9636

  373. Prognostic value of home heart rate for cardiovascular mortality in the general population

    A Hozawa, T Ohkubo, M Kikuya, T Ugajin, J Yamaguchi, K Asayama, H Metoki, K Ohmori, H Hoshi, J Hashimoto, H Satoh, Tsuji, I, Y Imai

    AMERICAN JOURNAL OF HYPERTENSION　17　(11)　1005-1010　2004/11

    DOI： 10.1016/j.amjhyper.2004.06.019 　

    ISSN： 0895-7061

  374. 在宅健常高齢者に対する認知トレーニング介入効果の検討

    内田 信也, 川島 隆太, 寳澤 篤, 大森 芳, 辻 一郎

    日本公衆衛生学会総会抄録集　63回　673-673　2004/10

    Publisher: 日本公衆衛生学会

    ISSN： 1347-8060

  375. P-254 高齢者を対象とした高血圧治療薬服用状況調査 : 鶴ヶ谷寝たきり予防健診の結果から(17.在宅医療・医薬分業,"薬剤師がつくる薬物治療"-薬・薬・学の連携-)

    小林満, 大森芳, 海老原覚, 寳澤篤, 栗山進一, 尾形美樹子, 松井敏史, 辻一郎, 荒井啓行, 佐々木英忠

    日本医療薬学会年会講演要旨集　14　280-280　2004/09/01

    Publisher: 日本医療薬学会

    DOI： 10.20825/amjsphcs.14.0_280_2 　

  376. Increased plasma 8-isoprostane levels in hypertensive subjects: The Tsurugaya project

    A Hozawa, S Ebihara, K Ohmori, S Kuriyama, T Ugajin, Y Koizumi, Y Suzuki, T Matsui, H Arai, Y Tsubono, H Sasaki, Tsuji, I

    HYPERTENSION RESEARCH　27　(8)　557-561　2004/08

    DOI： 10.1291/hypres.27.557 　

    ISSN： 0916-9636

  377. Body mass index and cardiovascular disease in the Asia-Pacific Region: an overview of 33 cohorts involving 310 000 participants

    CN Mhurchu, A Rodgers, WH Pan, DF Gu, M Woodward, Parag, V, R Lin, DA Bennett, S Vander Hoorn, M Woodward, F Barzi, S MacMahon, DA Bennett, DF Gu, TH Lam, C Lawes, WH Pan, A Rodgers, Suh, I, H Ueshima, M Woodward, A Okayama, H Ueshima, H Maegawa, N Aoki, M Nakamura, N Kubo, T Yamada, ZS Wu, CH Yao, ZS Wu, LS Liu, JX Xie, MW Knuiman, H Christensen, XG Wu, J Zhou, XH Yu, A Tamakoshi, ZL Wu, LQ Chen, GL Shan, DF Gu, XF Duan, S MacMahon, R Norton, G Whitlock, R Jackson, M Fujishima, Y Kiyohara, H Iwamoto, J Woo, S Ho, Z Hong, MS Huang, B Zhou, JL Fuh, H Ueshima, Y Kita, Choudhury, SR, Suh, I, SH Jee, IS Kim, G Giles, T Hashimoto, K Sakata, Y Imai, T Ohkubo, A Hozawa, K Jamrozik, M Hobbs, R Broadhurst, K Nakachi, XH Fang, SC Li, QD Yang, ZM Chen, H Tanaka, Y Kita, A Nozaki, H Ueshima, H Horibe, Y Matsutani, M Kagaya, K Hughes, J Lee, D Heng, BF Zhou, HY Zhang, K Shimamoto, S Saitoh, ZZ Li, HY Zhang, WH Pan, Y He, TH Lam, SX Yao

    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY　33　(4)　751-758　2004/08

    DOI： 10.1093/ije/dyh163 　

    ISSN： 0300-5771

  378. Methodological issues for a large-scale intervention trial of lifestyle modification: Interim assessment of the High-Risk and Population Strategy for Occupational Health Promotion (HIPOP-OHP) Study

    Tomonori Okamura, Taichiro Tanaka, Toru Takebayashi, Hideaki Nakagawa, Hiroshi Yamato, Katsushi Yoshita, Takashi Kadowaki, Akira Okayama, Hirotsugu Ueshima

    Environmental Health and Preventive Medicine　9　(4)　137-143　2004/07

    DOI： 10.1265/ehpm.9.137 　

    ISSN： 1342-078X

  379. 【サイコオンコロジーの新たな展開】 パーソナリティーとがん罹患に関する前向きコホート研究

    中谷 直樹, 坪野 吉孝, 細川 徹, 西野 善一, 大久保 孝義, 寳澤 篤, 渋谷 大助, 福土 審, 深尾 彰, 辻 一郎, 久道 茂

    心身医学　44　(7)　471-477　2004/07

    Publisher: (一社)日本心身医学会

    DOI： 10.15064/jjpm.44.7_471 　

    ISSN： 0385-0307

  380. がん検診の実施状況に関する市区町村実態調査

    中谷 直樹, 大森 芳, 鈴木 寿則, 寳澤 篤, 栗山 進一, 坪野 吉孝, 辻 一郎

    日本公衆衛生雑誌　51　(7)　530-539　2004/07

    Publisher: 日本公衆衛生学会

    DOI： 10.11236/jph.51.7_530 　

    ISSN： 0546-1766

  381. 福島県西会津町における町ぐるみ健康増進事業と10年間の変化

    栗山 進一, 寳澤 篤, 島津 太一, 藤田 潤一, 渡部 英樹, 新田 幸恵, 辻 一郎

    東北公衆衛生学会誌　(53)　14-14　2004/07

    Publisher: 東北公衆衛生学会

    ISSN： 0915-549X

  382. 高齢者の口腔状態と栄養摂取量との関連

    水戸 祐子, 高津 匡樹, 菊池 雅彦, 玉澤 佳純, 服部 佳功, 坪井 明人, 佐藤 智昭, 岩松 正明, 小牧 健一朗, 伊藤 進太郎, 土谷 昌広, 舩山 恭子, 大井 孝, 秋葉 陽介, 寶沢 篤, 辻 一郎, 渡辺 誠

    日本補綴歯科学会雑誌　48　(111回特別)　118-118　2004/05

    Publisher: (公社)日本補綴歯科学会

    ISSN： 0389-5386

    eISSN： 1883-177X

  383. 都市に在住する70歳以上の高齢者のソーシャル・サポートと抑うつ症状との関連性 一年間の前向きコホート研究の結果について

    小泉 弥生, 粟田 主一, 関 徹, 大森 芳, 栗山 進一, 寶澤 篤, 松岡 洋夫, 辻 一郎

    老年精神医学雑誌　15　(5)　593-594　2004/05

    Publisher: (株)ワールドプランニング

    ISSN： 0915-6305

  384. 都市の大規模住宅地域に在住する70歳以上高齢者の自殺念慮と関連要因 1年間のコホート研究

    粟田 主一, 関 徹, 小泉 弥生, 佐藤 宗一郎, 大森 芳, 栗山 進一, 寶澤 篤, 辻 一郎, 松岡 洋夫

    老年精神医学雑誌　15　(5)　594-595　2004/05

    Publisher: (株)ワールドプランニング

    ISSN： 0915-6305

  385. 地域在住の高齢者における頭部MRI上の脳血管性病変と抑うつ症状との関連 横断的研究

    関 徹, 粟田 主一, 小泉 弥生, 木之村 重男, 後藤 了以, 井上 健太郎, 瀧 靖之, 寶澤 篤, 大森 芳, 栗山 進一, 松岡 洋夫, 福田 寛, 辻 一郎

    老年精神医学雑誌　15　(5)　595-596　2004/05

    Publisher: (株)ワールドプランニング

    ISSN： 0915-6305

  386. 高齢者の口腔状態と栄養摂取量との関連

    水戸祐子, 高津匡樹, 菊池雅彦, 玉沢佳純, 服部佳功, 坪井明人, 佐藤智昭, 宝沢篤, 辻一郎

    日本補綴歯科学会学術大会プログラム・抄録集　111th　(111回特別)　118-118　2004/05

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

  387. 高齢者におけるビタミンサプリメント摂取者の生活習慣に関する研究 鶴ヶ谷寝たきり予防健診

    尾形 美樹子, 栗山 進一, 寳澤 篤, 大森 芳, 松井 敏史, 海老原 覚, 荒井 啓行, 佐々木 英忠, 辻 一郎

    日本老年医学会雑誌　41　(Suppl.)　104-104　2004/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  388. 高齢者における肥満とうつ状態に関する横断研究 鶴ヶ谷寝たきり予防健診

    栗山 進一, 小泉 弥生, 大森 芳, 寳澤 篤, 粟田 主一, 荒井 啓行, 佐々木 英忠, 辻 一郎

    日本老年医学会雑誌　41　(Suppl.)　123-123　2004/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  389. 地域高齢者の抑うつと医療費 鶴ヶ谷寝たきり予防健診

    大森 芳, 鈴木 寿則, 小泉 弥生, 寳澤 篤, 栗山 進一, 粟田 主一, 荒井 啓行, 佐々木 英忠, 辻 一郎

    日本老年医学会雑誌　41　(Suppl.)　138-138　2004/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  390. 【分子高血圧 最新の進歩】 高血圧における遺伝因子の関与 高血圧感受性遺伝子の遺伝子多型,遺伝子発現の解析から

    杉本 研, 勝谷 友宏, 大石 充, 楽木 宏実, 荻原 俊男, 寳澤 篤, 辻 一郎, 大久保 孝義, 今井 潤

    血圧　11　(3)　285-288　2004/03

    Publisher: (株)先端医学社

    ISSN： 1340-4598

  391. 【高血圧と高血圧性臓器障害 臓器障害の予防と管理】 合併症・臓器障害予防の血圧管理 24時間自由行動下血圧,家庭血圧

    寳澤 篤, 今井 潤

    日本臨床　62　(増刊3 高血圧と高血圧性臓器障害)　403-407　2004/03

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  392. 性格と癌罹患に関する前向きコホート研究(第55回日本心身医学会東北地方会演題抄録)

    中谷 直樹, 坪野 吉孝, 西野 善一, 大久保 孝義, 寶澤 篤, 細川 徹, 渋谷 大助, 福土 審, 辻 一郎

    心身医学　44　(2)　153-153　2004/02/01

    Publisher: 日本心身医学会

    DOI： 10.15064/jjpm.44.2_153_1 　

    ISSN： 0385-0307

  393. Cigarette smoking and mortality in Japan: The Miyagi Cohort Study

    Atsushi Hozawa, Takayoshi Ohkubo, Junko Yamaguchi, Takashi Ugajin, Yayoi Koizumi, Yoshikazu Nishino, Yoshitaka Tsubono, Daisuke Shibuya, Ichiro Tsuji, Akira Fukao, Shigeru Hisamichi

    Journal of Epidemiology　14　(1)　S12-S17　2004

    DOI： 10.2188/jea.14.S12 　

    ISSN： 0917-5040

  394. Association between social support and depression in the elderly Japanese population

    Koizumi Yayoi, Arai Hiroyuki, Tsuji Ichiro, Awata Shuichi, Seki Toru, Nakaya Naoki, Kuriyama Shinichi, Suzuki Yoshinori, Ohmori Kaori, Hozawa Atsushi, Ebihara Satoru

    Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics　41　(4)　426-433　2004

    Publisher: The Japan Geriatrics Society

    DOI： 10.3143/geriatrics.41.426 　

    ISSN： 0300-9173

  395. 在宅高齢者の口腔健康状態と咀嚼能力に関する調査研究

    高津 匡樹, 菊池 雅彦, 玉澤 佳純, 服部 佳功, 坪井 明人, 佐藤 智昭, 岩松 正明, 小牧 健一朗, 伊藤 進太郎, 土谷 昌広, 舩山 恭子, 大井 孝, 秋葉 陽介, 寶沢 篤, 辻 一郎, 渡辺 誠

    日本補綴歯科学会雑誌　47　(110回特別)　142-142　2003/10

    Publisher: (公社)日本補綴歯科学会

    ISSN： 0389-5386

    eISSN： 1883-177X

  396. 在宅高齢者の口腔健康状態とそしゃく能力に関する調査研究

    高津匡樹, 菊池雅彦, 玉沢佳純, 服部佳功, 坪井明人, 佐藤智昭, 宝沢篤, 辻一郎, 渡辺誠

    日本補綴歯科学会学術大会プログラム・抄録集　110th　142　2003/10

    ISSN： 1883-4426

  397. 自由行動下血圧の生命予後予測能-大迫研究 最長14年の追跡

    菊谷 昌浩, 大久保 孝義, 寳澤 篤, 浅山 敬, 大森 芳, 目時 弘仁, 星 晴久, 橋本 潤一郎, 佐藤 洋, 辻 一郎, 今井 潤

    日本高血圧学会総会プログラム・抄録集　26回　43-43　2003/10

    Publisher: (NPO)日本高血圧学会

  398. 白衣性高血圧者は持続性高血圧へ移行するか?

    宇賀神 卓嗣, 寳澤 篤, 大久保 孝義, 大森 芳, 星 晴久, 佐藤 洋, 辻 一郎, 今井 潤

    日本高血圧学会総会プログラム・抄録集　26回　83-83　2003/10

    Publisher: (NPO)日本高血圧学会

  399. 8-イソプロスタンは高血圧者で高値を示す

    寳澤 篤, 海老原 覚, 大森 芳, 栗山 進一, 大久保 孝義, 宇賀神 卓嗣, 小泉 弥生, 鈴木 寿則, 松井 敏史, 荒井 啓行, 坪野 吉孝, 今井 潤, 佐々木 英忠, 辻 一郎

    日本高血圧学会総会プログラム・抄録集　26回　154-154　2003/10

    Publisher: (NPO)日本高血圧学会

  400. 電子血圧計を用いた客観的な高血圧治療に関する研究(HOMED-BP Study)中間報告:2003年3月末における割付状況および家庭血圧値の推移

    今井 潤, 齊藤 伸, 浅山 敬, 大久保 孝義, 菊谷 昌浩, 寳澤 篤, 橋本 潤一郎, 三浦 幸雄

    日本高血圧学会総会プログラム・抄録集　26回　162-162　2003/10

    Publisher: (NPO)日本高血圧学会

  401. JNC-7分類に基づいた家庭血圧と随時血圧の脳卒中発症予測能:大迫研究

    浅山 敬, 大久保 孝義, 菊谷 昌浩, 寳澤 篤, 大森 芳, 目時 弘仁, 星 晴久, 橋本 潤一郎, 佐藤 洋, 辻 一郎, 今井 潤

    日本高血圧学会総会プログラム・抄録集　26回　195-195　2003/10

    Publisher: (NPO)日本高血圧学会

  402. 日本における大規模循環器疾患臨床試験の現状 電子血圧計を用いた客観的な高血圧治療に関する研究 多施設前向き無作為オープン結果遮蔽試験(Hypertension Objective Treatment based on Measurement by Electrical Devices of Blood Pressure)HOMED-BP研究

    今井 潤, 大久保 孝義, 橋本 潤一郎, 西村 拓也, 寶沢 篤, 青木 洋平, 三浦 幸雄

    臨床研究・生物統計研究会誌　23　(1)　4-7　2003/08

    Publisher: 臨床研究・生物統計研究会

    ISSN： 1347-5401

  403. 【高血圧の最新治療 生活習慣病としての診療ストラテジー】 診療におけるエビデンス 大迫研究

    山口 純子, 寳澤 篤, 今井 潤

    臨床医　29　(7)　1375-1377　2003/07

    Publisher: (株)中外医学社

    ISSN： 0388-2969

  404. 都市部に在住する70歳以上の高齢者の抑うつ症状と脳血管性危険因子との関連

    関 徹, 粟田 主一, 小泉 弥生, 松岡 洋夫, 佐藤 宗一郎, 寶澤 篤, 大森 芳, 栗山 進一, 辻 一郎, 荒井 啓行

    老年精神医学雑誌　14　(5)　655-656　2003/05

    Publisher: (株)ワールドプランニング

    ISSN： 0915-6305

  405. 都市部に在住する70歳以上高齢者の抑うつ症状,うつ病性障害,自殺念慮

    粟田 主一, 関 徹, 小泉 弥生, 松岡 洋夫, 佐藤 宗一郎, 寶澤 篤, 大森 芳, 栗山 進一, 荒井 啓行, 永富 良一, 辻 一郎

    老年精神医学雑誌　14　(5)　659-659　2003/05

    Publisher: (株)ワールドプランニング

    ISSN： 0915-6305

  406. 【医療経済から考える高血圧治療の現況と将来展望】 循環器疾患における予防医療の経済効果

    寳澤 篤, 辻 一郎

    血圧　10　(5)　499-503　2003/05

    Publisher: (株)先端医学社

    ISSN： 1340-4598

  407. 高血圧の発症要因:家庭血圧を用いた検討 大迫研究

    宇賀神 卓嗣, 寳澤 篤, 大久保 孝義, 大森 芳, 佐藤 洋, 辻 一郎, 今井 潤

    日本老年医学会雑誌　40　(Suppl.)　129-129　2003/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  408. 家庭高血圧と8イソプロスタンの関連について 鶴ヶ谷寝たきり予防健診

    寳澤 篤, 海老原 覚, 大森 芳, 宇賀神 卓嗣, 栗山 進一, 大久保 孝義, 荒井 啓行, 佐々木 英忠, 今井 潤, 辻 一郎

    日本老年医学会雑誌　40　(Suppl.)　130-130　2003/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  409. 生体内酸化ストレスマーカーとしての血中8-イソプロスタンに関する記述疫学 鶴ヶ谷寝たきり予防健診

    栗山 進一, 荒井 啓行, 海老原 覚, 松井 敏史, 寳澤 篤, 大森 芳, 藤田 和樹, 坪野 吉孝, 佐々木 英忠, 辻 一郎

    日本老年医学会雑誌　40　(Suppl.)　137-137　2003/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  410. 鶴ヶ谷プロジェクト 地域高齢者に対する総合機能評価の実施

    大森 芳, 寳澤 篤, 栗山 進一, 藤田 和樹, 粟田 主一, 荒井 啓行, 永富 良一, 佐々木 英忠, 辻 一郎

    日本老年医学会雑誌　40　(Suppl.)　142-142　2003/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  411. 高齢者における過敏性腸症候群及び機能性消化管障害の抑うつ症状とQuality of Life

    中谷 直樹, 藤田 和樹, 寳澤 篤, 小泉 弥生, 大森 芳, 倉嶋 佳誉子, 辻 一郎, 粟田 主一, 福土 審

    老年精神医学雑誌　14　(5)　628-628　2003/05

    Publisher: (株)ワールドプランニング

    ISSN： 0915-6305

  412. 都市に在住する70歳以上の高齢者のソーシャルサポートと抑うつ症状との関連性

    小泉 弥生, 粟田 主一, 関 徹, 松岡 洋夫, 中谷 直樹, 栗山 進一, 大森 芳, 寳澤 篤, 辻 一郎, 藤田 和樹, 永富 良一, 海老原 覚, 荒井 啓行

    老年精神医学雑誌　14　(5)　629-629　2003/05

    Publisher: (株)ワールドプランニング

    ISSN： 0915-6305

  413. Therapeutic effects of evening administration of guanabenz and clonidine on morning hypertension: evaluation using home-based blood pressure measurements

    J Hashimoto, K Chonan, Y Aoki, T Ugajin, J Yamaguchi, T Nishimura, M Kikuya, M Michimata, M Matsubara, T Araki, A Hozawa, T Ohkubo, Y Imai

    JOURNAL OF HYPERTENSION　21　(4)　805-811　2003/04

    DOI： 10.1097/01.hjh.0000052481.18130.69 　

    ISSN： 0263-6352

  414. 岩手県大迫町における運動訓練の効果-筋力,バランスなど

    藤田 和樹, 寳澤 篤, 中谷 直樹, 大森 芳, 鈴木 寿則, 山口 純子, 辻 一郎, 古川 順光, 佐藤 浩哉, 永富 良一

    宮城県公衆衛生学会会誌　(35)　7-7　2003/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  415. Suicidal ideation, depressive symptoms and depressive disorder in an elderly Japanese population

    S Awata, T Seki, Y Koizumi, S Sato, H Matsuoka, H Arai, A Hozawa, K Omori, S Kuriyama, Tsuji, I

    INTERNATIONAL PSYCHOGERIATRICS　15　296-297　2003

    ISSN： 1041-6102

  416. Association between depression and social support in the Japanese elderly population

    Y Koizumi, S Awata, T Seki, N Nakaya, S Kuriyama, K Fujita, K Ohmori, A Hozawa, S Ebihara, H Arai, R Nagatomi, H Matsuoka, Tsuji, I

    INTERNATIONAL PSYCHOGERIATRICS　15　272-272　2003

    ISSN： 1041-6102

  417. コホート研究の成果 岩手県大迫町研究

    宇賀神 卓嗣, 寳澤 篤, 今井 潤

    動脈硬化予防　1　(3)　86-89　2003/01

    Publisher: (株)メジカルビュー社

    ISSN： 1347-7056

  418. Heart rate measurement and outcome

    Yutaka Imai, Atsushi Hozawa, Takayoshi Ohkubo, Kaori Ohmori, Masahiro Kikuya, Junichiro Hashimoto, Mari Michimata, Mistunobu Matsubara, Junko Yamaguchi, Takashi Ugajin, Tsutomu Araki, Ichiro Tsuji

    Blood Pressure Monitoring　8　53-55　2003/01/01

    DOI： 10.1097/00126097-200302000-00011 　

    ISSN： 1359-5237

  419. 音への恐怖を示すタイプの広汎性発達障害児に対するピリドキシンの効果

    上山 真知子, 渡辺 瑞香子, 玉橋 征子, 村口 至, 渡部 徹, 栗山 進一, 寶沢 篤, 大久保 孝義, 西野 善一, 坪野 吉孝, 辻 一郎, 久道 茂

    臨床神経心理　13　55-58　2002/12

    Publisher: 東北神経心理懇話会

    ISSN： 1344-0292

  420. Pulse wave velocity and the second derivative of the finger photoplethysmogram in treated hypertensive patients: their relationship and associating factors

    J Hashimoto, K Chonan, Y Aoki, T Nishimura, T Ohkubo, A Hozawa, M Suzuki, M Matsubara, M Michimata, T Araki, Y Imai

    JOURNAL OF HYPERTENSION　20　(12)　2415-2422　2002/12

    DOI： 10.1097/00004872-200212000-00021 　

    ISSN： 0263-6352

  421. Ambulatory and clinic BP as predictors of stroke incidence and CV mortality: Analysis of studies from Italy, Japan and USA

    JE Schwartz, Y Imai, P Verdecchio, TG Pickering, T Ohkubo, A Hozawa, J Whyte, GJ L'Italien, P Lapuerta, RS Chen

    CIRCULATION　106　(19)　759-760　2002/11

    ISSN： 0009-7322

  422. 電子血圧計を用いた客観的な高血圧治療に関する研究(Hypertension Objective Treatment based on Measurement by Electrical Devices of Blood Pressure Study-HOMED-BP Study)

    西村 拓矢, 大久保 孝義, 青木 洋平, 菊谷 昌浩, 橋本 潤一郎, 寶澤 篤, 松原 光伸, 三浦 幸雄, 今井 潤

    日本高血圧学会総会プログラム・抄録集　25回　119-119　2002/10

    Publisher: (NPO)日本高血圧学会

  423. レニン-アンギオテンシン-アルドステロン系の主要遺伝子多型と24時間自由行動下血圧 大迫研究

    菊谷 昌浩, 松原 光伸, 鈴木 倫子, 道又 真理, 橋本 潤一郎, 風間 逸郎, 辻 一郎, 大久保 孝義, 寳沢 篤, 杉本 研, 勝谷 友宏, 荻原 俊男, 藤原 亨, 今井 潤

    日本高血圧学会総会プログラム・抄録集　25回　209-209　2002/10

    Publisher: (NPO)日本高血圧学会

  424. 随時測定における正の心拍数-血圧関連は家庭における測定ではみられない

    山口 純子, 寳澤 篤, 大久保 孝義, 大森 芳, 菊谷 昌浩, 橋本 潤一郎, 松原 光伸, 星 晴久, 荒木 勉, 佐藤 洋, 辻 一郎, 今井 潤

    日本高血圧学会総会プログラム・抄録集　25回　219-219　2002/10

    Publisher: (NPO)日本高血圧学会

  425. アディポネクチン遺伝子多型と高血圧との関連の検討(大迫研究)

    岩嶋 義雄, 勝谷 友宏, 寳澤 篤, 松原 光伸, 大久保 孝義, 杉本 研, 元根 正晴, 楽木 宏実, 檜垣 實男, 辻 一郎, 今井 潤, 荻原 俊男

    日本高血圧学会総会プログラム・抄録集　25回　245-245　2002/10

    Publisher: (NPO)日本高血圧学会

  426. 【高血圧の全て】 高血圧の臨床 家庭血圧 大迫研究の結果を中心に

    寳澤 篤, 今井 潤

    医学のあゆみ　202　(9)　611-615　2002/08

    Publisher: 医歯薬出版(株)

    ISSN： 0039-2359

  427. C3123A polymorphism of angiotensin II type 2 receptor gene is associated with hypertension in younger female: The Ohasama study

    K Sugimoto, T Katsuya, A Hozawa, M Matsubara, T Ohkubo, S Hisamachi, J Higaki, Y Imai, T Ogihara

    JOURNAL OF HYPERTENSION　20　S21-S21　2002/06

    ISSN： 0263-6352

  428. A new gene polymorphism located nearby 11 beta-hydroxysteroid dehydrogenase type 1 gene associates with high blood pressure

    Y Iwashima, T Katsuya, A Hozawa, M Matsubara, T Ohkubo, J Higaki, S Hisamichi, Y Imai, T Ogihara

    JOURNAL OF HYPERTENSION　20　S25-S25　2002/06

    ISSN： 0263-6352

  429. Ser326Cys (C1245G) polymorphism of 8-hydroxyguanine DNA glycosylase (hOGG1) gene is associated with hypertension in the Ohasama study

    K Sugimoto, T Katsuya, A Hozawa, M Matsubara, Tsuji, I, S Hisamichi, J Higaki, Y Imai, T Ogihara

    JOURNAL OF HYPERTENSION　20　S21-S21　2002/06

    ISSN： 0263-6352

  430. 広汎性発達障害児サブグループに対するビタミンB6の有効性に関する研究

    渡辺 瑞香子, 上山 真知子, 玉橋 征子, 村口 至, 渡辺 徹, 栗山 進一, 寶澤 篤, 大久保 孝義, 西野 善一, 坪野 吉孝

    脳と発達　34　(Suppl.)　S287-S287　2002/06

    Publisher: (一社)日本小児神経学会

    ISSN： 0029-0831

  431. 高齢者に対する運動訓練の日常身体活動量に及ぼす長期的効果の検証

    藤田 和樹, 永富 良一, 寶沢 篤, 大久保 孝義, 玉川 明朗, 辻 一郎, 久道 茂

    日本老年医学会雑誌　39　(Suppl.)　93-93　2002/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  432. Ser326Cys Polymorphism of 8-Hydroxyguanine DNA Glycosylase (hOGG1) Gene is Associated with Hypertension in the Ohasama Study

    Sugimoto Ken, Katsuya Tomohiro, Iwashima Yoshio, Motone Masaharu, Higaki Jitsuo, Ogihara Toshlo, Matsubara Mitsunobu, Imai Yutaka, Hozawa Atsushi, Ohkubo Takayoshi, Tsuji Ichiro, Hisamichi Shigeru

    Circulation journal : official journal of the Japanese Circulation Society　66　764-764　2002/03/31

    Publisher: Japanese Circulation Society

    ISSN： 1346-9843

  433. A single nuctreotide polymorphism in the HSD11B1 locus associates with blood pressure

    Iwashima Yoshio, Katsuya Tomohiro, Sugimoto Ken, Hukuda Masayuki, Motone Masaharu, Higaki Jitsuo, Ogihara Toshio, Hozawa Atsushi, Okubo Takayoshi, Tsuji Ichiro, Hisamichi Shigeru, Matsubara Mitsunobu, Imai Yutaka

    Circulation journal : official journal of the Japanese Circulation Society　66　358-358　2002/03/31

    Publisher: Japanese Circulation Society

    ISSN： 1346-9843

  434. 【分子高血圧 最新の進歩】 神経ペプチドY(NPY)遺伝子多型と循環器疾患リスク

    福田 雅行, 寶澤 篤, 勝谷 友宏, 大久保 孝義, 松原 光伸, 杉本 研, 付 欲暁, 岩嶋 義雄, 辻 一郎, 貴田岡 博史, 檜垣 實男, 久道 茂, 今井 潤, 荻原 俊男

    血圧　9　(3)　327-330　2002/03

    Publisher: (株)先端医学社

    ISSN： 1340-4598

  435. 高齢者の死亡前要介護期間の関連因子 : 大崎コホート研究

    大森 芳, 寳澤 篤, 渡辺 洋子, 大久保 孝義, 西野 善一, 坪野 吉孝, 辻 一郎, 佐々木 淳, 久道 茂

    Journal of epidemiology　12　(1)　2002/01/01

    ISSN： 0917-5040

  436. 家庭血圧計により測定された心拍数の規定因子 : 大迫研究

    山口 純子, 寳澤 篤, 大久保 孝義, 大森 芳, 星 晴久, 辻 一郎, 佐藤 洋, 久道 茂, 今井 潤

    Journal of epidemiology　12　(1)　2002/01/01

    ISSN： 0917-5040

  437. 在宅高齢者における認知機能と、3種類の測定方法によって得られた血圧値との関連 : 大迫研究

    平野 幹雄, 寳澤 篤, 大久保 孝義, 辻 一郎, 細川 徹, 久道 茂, 高山 忠雄, 今井 潤

    Journal of epidemiology　12　(1)　2002/01/01

    ISSN： 0917-5040

  438. Blood pressure control assessed by home, ambulatory and conventional blood pressure measurements in the Japanese general population: The Ohasama study

    Atsushi Hozawa, Takayoshi Ohkubo, Masahiro Kikuya, Junko Yamaguchi, Kaori Ohmori, Tohru Fujiwara, Junichiro Hashimoto, Mitsunobu Matsubara, Hirofumi Kitaoka, Kenichi Nagai, Ichiro Tsuji, Hiroshi Satoh, Shigeru Hisamichi, Yutaka Imai

    Hypertension Research　25　(1)　57-63　2002

    DOI： 10.1291/hypres.25.57 　

    ISSN： 0916-9636

  439. Relationship between personality and self-measured blood pressure value at home: The Ohasama study

    Atsushi Hozawa, Takayoshi Ohkubo, Ichiro Tsuji, Masahiro Kikuya, Mitsunobu Matsubara, Toshinobu Suzuki, Kenichi Nagai, Hirofumi Kitaoka, Yumiko Arai, Toru Hosokawa, Hiroshi Satoh, Shigeru Hisamichi, Yutaka Imai

    Clinical and Experimental Hypertension　24　(1-2)　115-123　2002

    DOI： 10.1081/CEH-100108722 　

    ISSN： 1064-1963

  440. Genotypes of the βENaC gene have little influence on blood pressure level in the Japanese population

    Mitsunobu Matsubara, Hirohito Metoki, Michiko Suzuki, Tohru Fujiwara, Masahiro Kikuya, Mari Michimata, Takayoshi Ohkubo, Atsushi Hozawa, Ichiro Tsuji, Shigeru Hisamichi, Tsutomu Araki, Yutaka Imai

    American Journal of Hypertension　15　(2 I)　189-192　2002

    DOI： 10.1016/S0895-7061(01)02266-X 　

    ISSN： 0895-7061

  441. Prognostic impact of 24-hour mean blood pressure and pulse pressure on stroke.

    T. Ohkubo, A. Hozawa, Y. Imai

    Circulation　104　2001/12/18

    ISSN： 1524-4539

  442. Prognostic impact of 24-hour mean blood pressure and pulse pressure on stroke

    T Ohkubo, A Hozawa, Y Imai

    CIRCULATION　104　(25)　E160-E160　2001/12

    ISSN： 0009-7322

  443. Predictive values of automated blood pressure measurement: what can we learn from the Japanese population - the Ohasama study

    Y Imai, A Hozawa, T Ohkubo, Tsuji, I, J Yamaguchi, M Matsubara, M Michimata, J Hashimoto, T Fujiwara, K Nagai, H Kitaoka, H Satoh, S Hisamichi

    BLOOD PRESSURE MONITORING　6　(6)　335-339　2001/12

    DOI： 10.1097/00126097-200112000-00013 　

    ISSN： 1359-5237

  444. Aldosterone synthase gene (CYP11B2) C-334T polymorphism, ambulatory blood pressure and nocturnal decline in blood pressure in the general Japanese population: the Ohasama Study

    M Matsubara, M Kikuya, T Ohkubo, H Metoki, F Omori, T Fujiwara, M Suzuki, M Michimata, A Hozawa, T Katsuya, J Higaki, Tsuji, I, T Araki, T Ogihara, H Satoh, S Hisamichi, K Nagai, H Kitaoka, Y Imai

    JOURNAL OF HYPERTENSION　19　(12)　2179-2184　2001/12

    DOI： 10.1097/00004872-200112000-00010 　

    ISSN： 0263-6352

  445. A1166C polymorphism of angiotensin 2 type 1 receptor gene is associated with blood pressure in the waking period: The Ohasama study

    K Sugimoto, T Katsuya, A Hozawa, M Motone, M Matsubara, T Okubo, Tsuji, I, J Higaki, Y Imai, T Ogihara

    CIRCULATION　104　(17)　339-340　2001/10

    ISSN： 0009-7322

  446. アンジオテンシンIIタイプ1レセプター遺伝子のA1166C多型が覚醒時血圧に関連する 大迫研究

    杉本 研, 勝谷 友宏, 寶澤 篤, 大久保 孝義, 松原 光伸, 辻 一郎, 浅井 尚志, 福田 雅博, 岩嶋 義雄, 元根 正晴

    日本高血圧学会総会プログラム・抄録集　24回　79-79　2001/10

    Publisher: (NPO)日本高血圧学会

  447. HOMED-BP研究

    藤原 亨, 橋本 潤一郎, 宝沢 篤, 大久保 孝義, 松原 光伸, 今井 潤

    日本高血圧学会総会プログラム・抄録集　24回　60-60　2001/10

    Publisher: (NPO)日本高血圧学会

  448. α-adducin遺伝子のG460T多型が高齢者の高血圧に関連する 大迫研究

    杉本 研, 勝谷 友宏, 寶澤 篤, 大久保 孝義, 松原 光伸, 辻 一郎, 浅井 尚志, 福田 雅博, 岩嶋 義雄, 元根 正晴

    日本高血圧学会総会プログラム・抄録集　24回　81-81　2001/10

    Publisher: (NPO)日本高血圧学会

  449. 家庭血圧値と家庭脈拍数の組み合わせは,より正確な脳心血管死亡予測を行うことを可能とする

    寳澤 篤, 大久保 孝義, 菊谷 昌浩, 山口 純子, 大森 芳, 藤原 亨, 橋本 潤一郎, 松原 光伸, 貴田岡 博史, 永井 謙一

    日本高血圧学会総会プログラム・抄録集　24回　61-61　2001/10

    Publisher: (NPO)日本高血圧学会

  450. alpha-adducin 460 polymorphism in a large Japanese population, the Ohasama Study, associates with essential hypertension.

    K Sugimoto, T Katsuya, A Hozawa, M Matsubara, H Kitaoka, C Tsuji, H Satoh, S Hisamichi, J Higaki, Y Imai, T Ogihara

    HYPERTENSION　38　(3)　496-497　2001/09

    ISSN： 0194-911X

  451. Effects of exercise training on home blood pressure values in older adults: a randomized controlled trial

    T Ohkubo, A Hozawa, R Nagatomi, K Fujita, C Sauvaget, Y Watanabe, Y Anzai, A Tamagawa, Tsuji, I, Y Imai, H Ohmori, S Hisamichi

    JOURNAL OF HYPERTENSION　19　(6)　1045-1052　2001/06

    DOI： 10.1097/00004872-200106000-00008 　

    ISSN： 0263-6352

  452. アルドステロン遺伝子CYP11B2多型と高血圧 大迫研究

    菊谷 昌浩, 松原 光伸, 寶澤 篤, 辻 一郎, 今井 潤

    日本老年医学会雑誌　38　(Suppl.)　93-93　2001/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  453. 【高血圧 Evidenceに基づく新しい治療指針】 診察室以外での血圧の評価

    寳澤 篤, 今井 潤

    治療学　35　(4)　399-402　2001/04

    Publisher: ライフサイエンス出版(株)

    ISSN： 0386-8109

  454. 【収縮期高血圧】 心血管合併症危険因子としての収縮期血圧,拡張期血圧,脈圧の意義 脳

    寳澤 篤, 今井 潤

    血圧　8　(4)　381-384　2001/04

    Publisher: (株)先端医学社

    ISSN： 1340-4598

  455. 高齢者に対する運動訓練の効果 RCT後半年の調査から

    寳澤 篤, 大久保 孝義, 辻 一郎, 久道 茂, 藤田 和樹, 永富 良一, 玉川 明朗, 佐藤 明, 大森 浩明, 入江 徳子, 斎藤 昌宏

    宮城県公衆衛生学会会誌　(33)　14-14　2001/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  456. Usefulness of home blood pressure measurements in assessing the effect of treatment in a single-blind placebo-controlled open trial

    Y Imai, T Ohkubo, A Hozawa, Tsuji, I, M Matsubara, T Araki, K Chonan, M Kikuya, H Satoh, S Hisamichi, K Nagai

    JOURNAL OF HYPERTENSION　19　(2)　179-185　2001/02

    DOI： 10.1097/00004872-200102000-00003 　

    ISSN： 0263-6352

  457. Factors affecting the difference between screening and home blood pressure measurements: The Ohasama study

    Atsushi Hozawa, Takayoshi Ohkubo, Kenichi Nagai, Masahiro Kikuya, Mitsunobu Matsubara, Ichiro Tsuji, Sadayoshi Ito, Hiroshi Satoh, Shigeru Hisamichi, Yutaka Imai

    Journal of Hypertension　19　(1)　13-19　2001

    DOI： 10.1097/00004872-200101000-00002 　

    ISSN： 0263-6352

  458. Endothelin-1 gene variant associates with blood pressure in obese Japanese subjects: The Ohasama study

    Takashi Asai, Takayoshi Ohkubo, Tomohiro Katsuya, Jitsuo Higaki, Yuxiao Fu, Masayuki Fukuda, Atsushi Hozawa, Mitsunobu Matsubara, Hirofumi Kitaoka, Ichiro Tsuji, Tsutomu Araki, Hiroshi Satoh, Shigeru Hisamichi, Yutaka Imai, Toshio Ogihara

    Hypertension　38　(6)　1321-1324　2001

    Publisher: Lippincott Williams and Wilkins

    DOI： 10.1161/hy1101.095333 　

    ISSN： 0194-911X

  459. Device for the self-measurement of blood pressure that can monitor blood pressure during sleep

    Kenichi Chonan, Masahiro Kikuya, Tsutomu Araki, Tohru Fujiwara, Michiko Suzuki, Mari Michimata, Junichiro Hashimoto, Takayoshi Ohkubo, Atsushi Hozawa, Norihito Yamamoto, Yoshinori Miyawaki, Mitsunobu Matsubara, Yutaka Imai

    Blood Pressure Monitoring　6　(4)　203-205　2001

    DOI： 10.1097/00126097-200108000-00008 　

    ISSN： 1359-5237

  460. Prognosis of isolated systolic and isolated diastolic hypertension as assessed by self-measurement of blood pressure at home - The Ohasama Study

    A Hozawa, T Ohkubo, K Nagai, M Kikuya, M Matsubara, Tsuji, I, S Ito, H Satoh, S Hisamichi, Y Imai

    ARCHIVES OF INTERNAL MEDICINE　160　(21)　3301-3306　2000/11

    ISSN： 0003-9926

  461. Prognosis of isolated systolic and isolated diastolic hypertension as assessed by self-measurement of blood pressure at home - The Ohasama Study

    A Hozawa, T Ohkubo, K Nagai, M Kikuya, M Matsubara, Tsuji, I, S Ito, H Satoh, S Hisamichi, Y Imai

    ARCHIVES OF INTERNAL MEDICINE　160　(21)　3301-3306　2000/11

    DOI： 10.1001/archinte.160.21.3301 　

    ISSN： 0003-9926

  462. Positive association between the Lys198 asn polymorphism in the endothelin-l and blood pressure in obese Japanese subjects: Ohasama study

    T Katsuya, T Ohkubo, YX Fu, Tsuji, I, K Nagai, T Asai, M Fukuda, A Hozawa, J Higaki, S Hisamichi, Y Imai, T Ogihara

    HYPERTENSION　36　(4)　714-714　2000/10

    ISSN： 0194-911X

  463. 高齢者への運動訓練が骨密度に及ぼす効果に関する無作為割付け対照試験

    辻 一郎, 渡辺 洋子, 西野 善一, 大久保 孝義, 寳澤 篤, 安斎 由貴子, 藤田 和樹, 永富 良一, 玉川 明朗, 大森 浩明, 久道 茂

    Osteoporosis Japan　8　(4)　628-632　2000/10

    Publisher: ライフサイエンス出版(株)

    ISSN： 0919-6307

  464. 【循環器疾患のコホート研究】 大迫研究

    寳澤 篤, 大久保 孝義, 今井 潤

    循環器科　48　(2)　114-120　2000/08

    Publisher: (有)科学評論社

    ISSN： 0388-1911

  465. 中年者の脈圧リスクは収縮期血圧高値による

    寳澤 篤, 大久保 孝義

    血圧　7　(7)　760-761　2000/07

    Publisher: (株)先端医学社

    ISSN： 1340-4598

  466. Japanese individuals do not harbor the T594M mutation but do have the P592S mutation in the C-terminus of the beta-subunit of the epithelial sodium channel: the Ohasama Study

    M Matsubara, T Ohkubo, M Michimata, A Hozawa, K Ishikawa, T Katsuya, K Nagai, Tsuji, I, J Higaki, T Araki, H Satoh, S Hisamichi, S Ito, T Ogihara, Y Imai

    JOURNAL OF HYPERTENSION　18　(7)　861-866　2000/07

    DOI： 10.1097/00004872-200018070-00007 　

    ISSN： 0263-6352

  467. Prognosis of isolated systolic and isolated diastolic hypertension assessed by self-measured blood pressure at home: The Ohasama study

    A Hozawa, T Ohkubo, K Nagai, M Kikuya, Tsuji, I, S Ito, H Satoh, S Hisamichi, Y Imai

    JOURNAL OF HYPERTENSION　18　S38-S39　2000/06

    ISSN： 0263-6352

  468. Effects of aerobic exercise training on home blood pressure values in older adults: A randomized controlled trial

    T Ohkubo, A Hozawa, R Nagatomi, C Sauvage, A Tamagawa, Tsuji, I, Y Imai, H Ohmori, S Hisamichi

    JOURNAL OF HYPERTENSION　18　S46-S46　2000/06

    ISSN： 0263-6352

  469. Personality affects the white coat effect defined as screening home blood pressure difference: The Ohasama study

    A Hozawa, Y Arai, T Ohkubo, K Nagai, Tsuji, I, S Ito, H Satoh, S Hisamichi, Y Imai

    JOURNAL OF HYPERTENSION　18　S178-S178　2000/06

    ISSN： 0263-6352

  470. 【高血圧up to date】 高血圧の臨床 最近の進歩 ABPM,家族血圧の基準値 大迫研究から

    寳澤 篤, 今井 潤

    Pharma Medica　18　(6)　49-54　2000/06

    Publisher: (株)メディカルレビュー社

    ISSN： 0289-5803

  471. 高齢者に対する持久性運動訓練の効果(最大酸素摂取量の改善率)に関する予測因子

    柳沢 信生, 辻 一郎, 永富 良一, 玉川 明朗, 大久保 孝義, カトリーヌ・ソバジェ, 寳澤 篤, 渡辺 洋子, 藤田 和樹, 小川 恵子, 入江 徳子, 齋藤 昌宏, 大森 浩明, 久道 茂

    宮城県公衆衛生学会会誌　(32)　15-15　2000/03

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  472. 【高血圧(上)】 本態性高血圧症 臨床 疫学 職域集団における長期追跡調査

    寳澤 篤, 大久保 孝義, 久道 茂

    日本臨床　58　(増刊 高血圧(上))　623-626　2000/01

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  473. Japanese individuals do not habor the T594M mutation but do have the p592S mutation in the C-terminus of the beta-subunit of the epithelial sodium channel: The Ohasama study

    M. Matsubara, T. Ohkubo, M. Michimata, A. Hozawa, T. Ishikawa, T. Katsuya, K. Nagai, I. Tsuji, J. Higaki, T. Araki, H. Satoh, S. Hisamichi, S. Ito, T. Ogihara, Y. Imai

    Japanese Pharmacology and Therapeutics　28　714　2000/01/01

    ISSN： 0386-3603

  474. Prospective studies of cardiovascular disease in Japanese work site population

    A. Hozawa, T. Ohkubo, S. Hisamichi

    Nippon rinsho. Japanese journal of clinical medicine　58 Suppl 1　623-626　2000/01/01

    ISSN： 0047-1852

  475. Prediction of stroke by ambulatory blood pressure monitoring versus screening blood pressure measurements in a general population: The Ohasama study

    Takayoshi Ohkubo, Atsushi Hozawa, Kenichi Nagai, Masahiro Kikuya, Ichiro Tsuji, Sadayoshi Ito, Hiroshi Satoh, Shigeru Hisamichi, Yutaka Imai

    Journal of Hypertension　18　(7)　847-854　2000

    Publisher: Lippincott Williams and Wilkins

    DOI： 10.1097/00004872-200018070-00005 　

    ISSN： 0263-6352

  476. Randomized, controlled trial of exercise training for older people (Sendai Silver Center Trial; SSCT): Study design and primary outcome

    Ichiro Tsuji, Akira Tamagawa, Ryoichi Nagatomi, Noriko In'E, Takayoshi Ohkubo, Masahiro Saito, Kazuki Fujita, Keiko Ogawa, Catherine Sauvaget, Yukiko Anzai, Atsushi Hozawa, Yoko Watanabe, Akira Sato, Hiroaki Ohmori, Shigeru Hisamichi

    Journal of Epidemiology　10　(1)　55-64　2000

    Publisher: Japan Epidemiology Association

    DOI： 10.2188/jea.10.55 　

    ISSN： 0917-5040

  477. Prognostic significance of blood pressure and heart rate variabilities: The Ohasama Study

    Masahiro Kikuya, Atsushi Hozawa, Takayoshi Ohokubo, Ichiro Tsuji, Mari Michimata, Mitsunobu Matsubara, Masahiro Ota, Kenichi Nagai, Tsutomu Araki, Hiroshi Satoh, Sadayoshi Ito, Shigeru Hisamichi, Yutaka Imai

    Hypertension　36　(5)　901-906　2000

    Publisher: Lippincott Williams and Wilkins

    DOI： 10.1161/01.HYP.36.5.901 　

    ISSN： 0194-911X

  478. Characteristics of blood pressure measured at home in the morning and in the evening: The Ohasama study

    Y Imai, A Nishiyama, M Sekino, A Aihara, M Kikuya, T Ohkubo, M Matsubara, A Hozawa, Tsuji, I, S Ito, H Satoh, K Nagai, S Hisamichi

    JOURNAL OF HYPERTENSION　17　(7)　889-898　1999/07

    DOI： 10.1097/00004872-199917070-00004 　

    ISSN： 0263-6352

  479. 【高血圧の全て】 高血圧の病型・診断・合併症 随時血圧,24時間自由行動下血圧,家庭血圧 特徴と基準値

    寳澤 篤, 今井 潤

    医学のあゆみ　189　(9)　599-604　1999/05

    Publisher: 医歯薬出版(株)

    ISSN： 0039-2359

  480. PDIII-2 自由行動下血圧・家庭血圧による高血圧診療の費用効果

    今井 潤, 永井 謙一, 佐藤 洋, 大久保 孝義, 寶沢 篤, 辻 一郎, 久道 茂, 伊藤 貞嘉

    Japanese circulation journal　63　(1)　1999/03/01

    Publisher: 社団法人日本循環器学会

    ISSN： 0047-1828

  481. 高齢者に対する持久性運動訓練の効果:RCTによる検討

    辻 一郎, 永富 良一, 玉川 明朗, 大久保 孝義, ソバジェ・カトリーヌ, 寳澤 篤, 渡辺 洋子, 大森 浩明, 久道 茂

    日本衛生学雑誌　54　(1)　283-283　1999/03

    Publisher: (一社)日本衛生学会

    ISSN： 0021-5082

  482. 高齢者における正常血圧群,高血圧治療群,高血圧未治療群の比較検討 随時血圧,家庭血圧,24時間自由行動下血圧を用いて

    寳澤 篤, 今井 潤, 相原 彰子, 関野 慎, 菊谷 昌浩, 伊藤 貞嘉, 大久保 孝義, 辻 一郎, 久道 茂, 佐藤 洋, 永井 謙一

    Therapeutic Research　20　(3)　627-630　1999/03

    Publisher: ライフサイエンス出版(株)

    ISSN： 0289-8020

  483. 大迫研究における正常血圧群,高血圧治療群,高血圧未治療群の比較検討 随時血圧,家庭血圧,24時間自由行動下血圧を用いて

    寳澤 篤, 今井 潤, 相原 彰子, 関野 慎, 菊谷 昌浩, 伊藤 貞嘉, 大久保 孝義, 辻 一郎, 久道 茂, 佐藤 洋, 永井 謙一

    Therapeutic Research　20　(1)　84-87　1999/01

    Publisher: ライフサイエンス出版(株)

    ISSN： 0289-8020

  484. Relationships among blood pressures obtained using different measurement methods in the general population of Ohasama, Japan

    Yutaka Imai, Takayoshi Ohkubo, Ichiro Tsuji, Atsushi Hozawa, Kenichi Nagai, Masahiro Kikuya, Akiko Aihara, Makoto Sekino, Mari Michimata, Mitsunobu Matsubara, Sadayoshi Ito, Hiroshi Satoh, Shigeru Hisamichi

    Hypertension Research - Clinical and Experimental　22　(4)　261-272　1999

    Publisher: Japanese Society of Hypertension

    DOI： 10.1291/hypres.22.261 　

    ISSN： 0916-9636

  485. 出生時体重と学童期家庭血圧値との関連

    寳澤 篤, 大久保 孝義, 辻 一郎, 今井 潤, 永井 謙一, 佐藤 洋, 久道 茂

    東北学校保健学会会誌　(46)　19-20　1998/09

    Publisher: 東北学校保健学会

    ISSN： 0912-215X

Show all ︎Show first 5

Research Projects 24

  1. Analysis of Oral and Cardiovascular Diseases Based on Real-World Data Including Metabolome and Claims Data

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2025/04/01 - 2030/03/31

  2. Usefulness of metabolite biomarker as a common pathway for the prevention of non-communicable diseases and frailty

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Keio University

    2023/04/01 - 2028/03/31

  3. 尿中ナトリウム、カリウム、ナトリウムカリウム比の関連がんの解明と方策の検討

    小暮 真奈, 寳澤 篤, 中谷 直樹

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2024/04/01 - 2027/03/31

  4. Development of a pandemic care management tool using municipal data, and verification of its relevance to the development of subsequent illnesses.

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2024/04/01 - 2027/03/31

  5. 特定健康診査における問診・検査項目の必要性・妥当性の検証、及び新たな項目の検討のための研究 Competitive

    岡村 智教, 三浦 克之, 後藤 励, 荒木田 美香子, 由田 克士, 田原 康玄, 寳澤 篤, 山岸 良匡, 平田 匠, 平田 あや

    Offer Organization: 厚生労働省

    System: 厚生労働科学研究費補助金

    Category: 循環器疾患・糖尿病等生活習慣病対策総合研究事業

    2024/04 - 2027/03

  6. 過敏性腸症候群発症の関連要因および家族集積性に関する大規模前向きコホート研究

    中谷 久美, 寳澤 篤, 中谷 直樹, 福土 審

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2023/04/01 - 2026/03/31

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    本研究の目的は、TMM計画地域住民コホート調査で以下の検討を行うことである。【研究1】IBS有病および発症とその関連要因の検討 (約16,000人規模での検討)、【研究2】IBSの家族集積性およびその関連要因の検討 (親子・夫婦約5,000ペア)によりIBS発症に関連する要因の因果の検証を含めた検討、また、家族で共有する環境要因の影響の検討が可能である。 【研究1】【研究2】を2023年度に開始した。【研究1】については、TMM計画地域住民コホート調査のベースライン調査参加者を対象にIBS有病に関連する要因の検討を行い、IBS有病と関連する要因として、年齢、震災での被災の程度、教育歴、歩行時間、主観的ストレス、心理的苦痛、うつが示された。中でも心理的要因である主観的ストレス、心理的苦痛、うつは、男女とも、また、全ての年齢階層で有意な関連を示し、IBSの病態において重要な要因である可能性が示唆された。本研究結果に関する論文はJournal of Neurogastroenterology and Motility誌に受理されている。また、追跡調査に参加した約16,000人を対象にIBS発症とその関連要因を検討するため、解析用データの構築を行った。今後、IBS発症に関連する要因を性、年齢などの基本情報に加え生活習慣、心理・社会的要因、健康状態、震災影響、生理指標の変数を用いて検討する。前向きコホートにより、関連要因の因果の検証が可能となる。 【研究2】については、約5,000組の親子および夫婦のIBS有病・発症の一致性を比較検討するためのデータの構築準備および文献検索を行った。親子のみならず夫婦も検討に含めることでIBS発症における共有環境の影響がより明確となる。 本研究によりIBS発症の関連要因および因果の検証、生活習慣や環境の影響の明確化によるIBSの病態解明を目指す。

  7. Research on the significance of sleep interventions for prevention of cardiovascular diseases in the elderly and middle-aged population

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Nara Medical University

    2023/04/01 - 2026/03/31

  8. 乳癌罹患リスク低減に向けた遺伝子多型、生活習慣、血漿メタボロームの統合解析

    石田 孝宣, 寳澤 篤, 布施 昇男, 濱中 洋平, 小柴 生造, 栗山 進一

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(B)

    Category: 基盤研究(B)

    Institution: 東北大学

    2020/04/01 - 2023/03/31

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    乳癌死亡数を減らすためには、個々の女性の乳癌罹患リスクを的確に評価し、そのリスクを低減することは重要な課題である。本研究は、日本人女性が自分の遺伝子多型と血漿メタボローム情報をもとに、乳癌罹患リスクを低減するために生活習慣をどのように改善すればよいかを知り、その効果を血漿メタボローム変化で知る個別化予防の構築を目的とする。 本研究はToMMoおよび大学病院のバイオバンクを利活用して、一般住民と乳癌患者の遺伝子多型、生活習慣、血漿メタボロームのデータを用いて解析する。乳癌罹患リスクに関連のある84の遺伝子多型、8つの血漿代謝物、改善・変更可能な身体情報・生活習慣（食習慣、住環境、睡眠、運動、嗜好、内服薬など）、および乳癌罹患の情報を用いて解析を行う。 コホート参加者の生活調査は登録時に行われており、全コホート参加者の全ゲノムシークエンスもしくはアレイ解析によるゲノム解析、血漿メタボローム解析が進められている。メタボローム解析は、NMR、GC-MS、LC-MSの3法が用いられおり、標的メタボローム解析法のMXp Quant 500 Kitを用いたLC-MS解析（500代謝物）は1,000人以上の成人女性に行われる予定である。 東北大学病院に通院している乳癌既往者約1,700人のうち、乳癌術後の無再発患者は約1,300人である。2021年度末には、計約800人が登録して血液検体保存がされる見込みであり、2022年度以降に、ToMMoが開発したSNPアレイであるジャポニカアレイNEOを用いたゲノム解析およびMXp Quant 500 Kitを用いたLC-MS解析を行う計画である。 以上の全体の研究実施計画のうち、2021年度は、大学病院においては乳癌患者のバイオバンク登録をすすめるとともに、メタボローム解析を行うためのデータ整理を行った。

  9. 血圧に対するナトリウムカリウム比感受性者の選別とその保健指導への活用に向けた研究

    小暮 真奈, 寳澤 篤

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(C)

    Category: 基盤研究(C)

    Institution: 東北大学

    2020/04/01 - 2023/03/31

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    高血圧の原因として、塩分の過剰摂取が知られている。またカリウム摂取による降圧効果も報告されているが、何れも測定に時間を要し、保健指導の現場での活用が困難であった。しかし、最近開発された尿中ナトリウムとカリウムの比（Na/K比）を評価する尿ナトカリ計により尿Na/K比が簡便かつ即時に測定可能となった。尿Na/K比測定を健診等の現場で活用することで、より分かりやすい高血圧指導が可能になると考えられる。しかし、これまでの知見によりNa/K比を下げても血圧が変化しない集団が存在することから、Na/K比の感受性について知見を深める必要もある。本研究では、東北メディカル・メガバンク計画の地域住民コホート調査のデータを用いてNa/K比の感受性遺伝子を同定することを目的として検討を行っている。 本年度は昨年度に引き続き、Na/K比・血圧・遺伝子に関連する先行研究を調べつつ、ゲノムデータの解析方法について東北メディカル・メガバンク機構のGWASセンター（SNPアレイ解析、GWAS解析を実施するセンター）とディスカッションを開始した。そこで専門の先生方より解析の方向性について助言をいただいたので解析対象者や解析方法について見直し、軌道修正を行った。また、GWAS解析を実施するにあたり、Linuxの使用方法についても習得を開始した。更に、前回作成したデータセットから詳細な情報を追加し、人数を増やしてアップデートを行った。今後GWASセンターのサポートを得ながら解析を進める予定である。

  10. The impact of genetic factors with the association between environmental factors and hypertension

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Hokkaido University

    2020/04/01 - 2023/03/31

  11. Development of risk prediction models for mild cognitive decline and frailty using metabolomics in a population-based cohort

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Keio University

    2018/04/01 - 2023/03/31

  12. Development of a tool to predict cognitive decline using metabolomics analysis

    Hozawa Atsushi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2019/04/01 - 2022/03/31

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    We observed that several metabolomics were associated with change in congnitive function. After excluding metabolomics which highly correlated with other metabolomics, we selected 6 metabolme markers to establish metabolome score. Using the score, higher metabolome score showed lower decline of cognitive function. Especially, participnts with metabolome score 0 showed marked decline in cognitive function The prediction model with metabome score showed larger area under the ROC curve(0.772) compared with the model without. Prediction model with metabolome score may have better potential to predict cognitive dysfucnction. Validation study using ToMMo is now analyzing.

  13. Epidemiological study regarding housing condition and health

    Hozawa Atsushi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Research (Exploratory)

    Institution: Tohoku University

    2019/06/28 - 2021/03/31

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    Previous studies reported the relationship between housing environment and health, although due to cost and effort, it was difficult to conduct housing condition surveys on a large scale. The CASBEE Housing Health Checklist (The Checklist) made it possible to easily evaluate housing condition from the resident’s perspective. In this study, we assessed the relation between housing condition and psychological distress and clarified that subjective housing condition was significantly related to psychological distress. This finding suggests that maintaining a comfortable thermal environment may affect residents’ mental health.

  14. Effects of Diet and Nutrients on Cognitive Indices and Brain Morphology: An Examination Using Omics Analysis

    Kogure Mana

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2017/04/01 - 2021/03/31

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    We examined the relationship between diet/food intake and brain morphology. The results showed that in the without energy intake adjusted, mushroom intake was significantly positively associated with gray matter capacity independent of confounding factors. In terms of dietary pattern, the group with the highest “Western food pattern” score had significantly higher gray matter capacity and hippocampal capacity. Furthermore, the results of omics analysis were added to the above analysis model, which suggested that amino acids may modify these relationships. This study examined the results of omics analysis using only representative amino acid results, we will examine the results in detail through collaborative research to identify metabolites that may contribute to brain well-activity in the future.

  15. Effect of Japanese food component on marker of athrosclerosis, research using metabolome measurement

    Atsushi Hozawa, Nakamura Tomohiro, Hirata Takumi, Kogure Mana, Oikawa Maki, Kisara Fuko, Yang Yunqing, Igarashi Yuka, Ichinohasama Fumi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

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    We measured information on metabolome. Participants of this study was (1) participants of Tohoku Medical Megabank Community Cohort Study (2) who measured cervical intina medina thickness(IMT), and (3) whose IMT was upper 25% or lower 25%. We selected participants considering age sex subgroup. Finally, we completed metabolome measurement from 2002 participants. We analyzeｄ the relation of IMT thickness with 165 items of metabolome measured by LC-MS and 37 items of metabolome measured by NMR. As a result, 3 items measured by LC-MS and 9 items measured by NMR was significantly associated with IMT thickness adjusting for age and sex.

  16. Psychosocial effect, lifestyle change, and disaster influence among the chronic disease patients under the catastrophic stress

    Naoki Nakaya, HOZAWA ATSUSHI, TOMITA HIROAKI, TSUCHIYA NAHO, NAKAMURA TOMOHIRO

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2014/04/01 - 2017/03/31

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    This study examined the psychosocial adverse effect, lifestyle change, and disaster influence among the chronic disease patients in the earthquake disaster area. We used data obtained from a population-based study of over 4,000 subjects to investigate the associations between medical treatments for chronic diseases (e.g. stroke, cancer, myocardial infarction), psychosocial adverse effects (psychological distress and depressive symptoms), lifestyle changes (smoking, alcohol, and sleeping status) and the degree of damage to homes (large-scale and small-degree). There was statistically significant increased risk of psychological distress among chronic disease patients to compare with non-chronic disease patients. The chronic disease patients show higher psychological distress among victims assumed to be high in a psychological distress. The need of the psychological support was shown as well as the physical care for the chronic disease patient.

  17. Effect of early treatment on prognosis after taking health check-up

    HOZAWA Atsushi, NARIMATSU Hiroto

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2012/04/01 - 2015/03/31

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    In this study, we followed-up untreated hypertensive participants for a year. We analyzed the action against hypertension after the participants pointed out their high blood pressure. Among 686 untreated hypertensive participants at baseline survey, 458 responded follow-up survey. Of 458 responders, 103 (22%) started antihypertensive medication, 98 (21%) visited clinicians without starting medication, 75 (16%) did not visit clinicians although they recognized their high blood pressure (BP), and 182 (40%) did not aware their high BP. Risk of unaware of high BP was lower BP. About half (43%) of participants with grade I hypertension did not aware of their high BP. Risk of not visiting clinician was alcohol drinking. Current smokers were more likely to start antihypertensive medication if they visit clinicians.

  18. Comparison Western Japan with Eastern Japan about the cause of asymptomatic cerebrovascular disorders and hippocampal atrophy in general Japanese men

    MIURA Katsuyuki, UESHIMA Hirotsugu, IMAI Yutaka, MURATA Kiyoshi, NOZAKI Kazuhiko, SHIINO Akihiko, OHKUBO Takayoshi, HOSAWA Atsushi, FUJIYOSHI Akira, HISAMATSU Takashi, HORIE Minoru, TOHYAMA Ikuo, TOTSUNE Kazuhito, ARAI Hiroyuki, MURAKAMI Yoshitaka, KADOTA Aya, KIKUYA Masahiro, NAGASAWA Shin-ya, ASAYAMA Kei, TOMITA Naoki, TAKASHIMA Naoyuki, HIROSE Takuo, SEKIKAWA Akira, KONDO Takeo, MIKI Tetsuro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Shiga University of Medical Science

    2011/04/01 - 2015/03/31

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    Stroke mortality is low in the Western Japan, while high in the Eastern Japan. In this study, we performed brain magnetic resonance imaging (MRI) in participants of cohort studies at Kusatsu (west) and Ohasama (east). First, we conducted MRI in same participants living in Ohasama at both Kusatsu and Ohasama facilities to investigate validity comparing West and East. Kappa coefficients between two facilities were about 0.60 in lacunar infarction and cerebral microbleed, 0.46 in white matter lesion. Then, we compared people in Kusatsu with these in Ohasama aged from 60 to 89 by age. Prevalence of lacunar infarction and that of cerebral microbleed were higher in Ohasama than in Kusatsu, and we thought that it might be occurred because people in Ohasama had higher blood pressure and percentage of medication of hypertension than Kusatsu in baseline characteristics. Meanwhile prevalence of white matter lesion was higher in Kusatsu than in Ohasama. That reason was not clear.

  19. 高齢正常血圧者に含まれるハイリスク者の同定とそのスクリーニング法についての研究

    寳澤 篤

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 挑戦的萌芽研究

    Category: 挑戦的萌芽研究

    2009 - 2010

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    若年者と比べて高齢者で、正常血圧者に対する高血圧者の循環器疾患・総死亡のリスク比が小さいことが知られている。しかし、高齢者においても降圧薬治療が生命予後を改善しうることが無作為割付対照試験で確認されており、高齢期の高血圧が無害であるというわけではなく、パラドックスが存在する。 そこで高齢一般住民正常血圧者に何らかのハイリスクな要因を持つ者が含まれているという仮説を立てた。血圧を低下させ、その後の予後を不良とする要因には潜在性心不全が考えられる。またうつ症状等の関与も考えられる。 平成22年度は、潜在性心不全により血圧が低下し、正常血圧かつ高BNPを呈するハイリスク者が存在する可能性について検討するために、仙台市宮城野区鶴ヶ谷地区で実施したコホート研究の512例分の保存血漿を用いてNT-pro BNP値を測定し、要介護発生及び死亡との関連を調査した。その結果、NT-pro BNPの下位25%(9-46pg/mL)の群に比べ上位90%(241pg/mL)以上の群で統計学的に有意な要介護+死亡リスク上昇が観察された(ハザード比:1.90;95%信頼区間:1.06-3.39)。以上から高齢者にNT-pro BNPを測定することがその要介護認定リスク、死亡リスク推定に有用である可能性が示された。しかしながら、仮説とは異なり、NT-pro BNPのリスク上昇はむしろ高血圧患者で顕著であった。したがって高齢正常血圧者ではなくむしろ高齢高血圧者でNT-pro BNP測定を実施することが予後の推定に有用であることが示された。NT-pro BNPを指標とした介入の有効性については今後の検討が必要となる。

  20. Epidemio logical study for clarifying the relation between nutrients assessed by serum sample and composite outcome of disability and death

    HOZAWA Atsushi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A)

    Category: Grant-in-Aid for Young Scientists (A)

    2009 - 2010

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    In this study, we investigated the relation between nutrients which associated with Japanese diet and incident disability. We found that higher serum equol showed lower risk for disability or death compared with non-producer of equol. However, other isoflavones, i. e., genistein, glycitein, and daidzein did not show any significant relations. Other nutrients, which we studied were fatty acids, folate, and vitamin B12. These nutrients did not show significant relation with incident disability or death.

  21. COMPARISON OF HOME BLOOD PRESSURE AND OFFICE BLOOD PRESSURE WHICH MEASURED UNDER IDEAL CIRCUMFERENCE FOR THE PREDICTION OF SUBCLINICAL ATHEROSCLEROSIS

    HOZAWA Atsushi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    2007 - 2008

  22. 循環器病リスク評価プログラムの開発、環境・遺伝因子からの多角的アプローチ

    寳澤 篤

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 特別研究員奨励費

    Category: 特別研究員奨励費

    Institution: 東北大学

    2002 - 2004

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    現在、岩手県稗貫郡大迫町の住民を追跡し、環境要因・遺伝要因双方の観点から24時間自由行動下血圧(ABP)、家庭血圧(HBP)の臨床的意義を追跡中である。また大迫町民の血液検体を用いて遺伝子多型とABP・HBPの関連を調査中である。以下に本年度報告した論文のうちを中心的なものにつき概要を示す。 1.心拍数と脳心血管死亡の関連 朝・晩の家庭心拍を3日以上測定した1780名を平均10年追跡したところ、104例の脳心血管死亡が観察された。種々の交絡因子を補正後の心拍数5bpm上昇あたりの相対ハザードは朝・晩それぞれ1.17、1.16でいずれも統計学的に有意であった。家庭血圧測定時に測定される家庭心拍が予後予測に有用であることを明らかにした。(論文2) 2.アンギオテンシンII 1型受容体(AT1R)の遺伝子多型A1166Cと高血圧の関連 AT1R/A1166Cと血圧の関連を随時血圧・家庭血圧双方を測定した1207名を対象に検討した。種々の交絡因子を補正後、随時血圧・家庭血圧双方においてAT1R/A1166Cと血圧には有意な関連は認められなかった。(論文4) 3.白衣性高血圧は将来の家庭高血圧を予測する。 家庭血圧が正常域にある者777名(家庭血圧 収縮期135mmHg未満かつ拡張期85mmHg)のうち随時血圧も正常域(随時血圧 収縮期140mmHg未満かつ拡張期90mmHg)にあった持続性正常血圧者649名と随時血圧が高血圧域にあった白衣性高血圧者128名についてその後の家庭高血圧(家庭血圧 収縮期135mmHg以上または拡張期85mmHg以上または降圧薬内服開始)発症を比較した。平均8年の追跡の結果、白衣高血圧者での高血圧発症オッズ比は2.86と有意に持続性正常血圧者よりも高かった。(論文5)

  23. ‐ Competitive

  24. - Competitive

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