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Yosuke Yamada

Section

Graduate School of Biomedical Engineering

Job title

Professor

Degree

博士（人間・環境学）（京都大学）
修士（人間・環境学）（京都大学）

researchmap

https://researchmap.jp/y.yamada

J-GLOBAL ID

200901079126031320

ORCID

https://orcid.org/0000-0002-4284-6317

Profile

2003 Bachelor, Faculty of Integrated Human Studies, Kyoto University
2005 Master of Science, Graduate School of Human & Environmental Studies, Kyoto University
2009 Ph.D, Graduate School of Human & Environmental Studies, Kyoto University

2007-2009 Research Fellow, Japan Society for the Promotion of Science
2009-2011 Post-doctoral Research Associate, Fukuoka University
2011-2014 Post-doctoral Research Fellow, Kyoto Prefectural University of Medicine
2011-2014 Superlative Post Doctorate Research Fellow, Japan Society for the Promotion of Science
2009 & 2013 Visiting Research Fellow, University of Wisconsin-Madison

2014-2019 Researcher, National Institute of Health and Nutrition
2019-2021 Associate Researcher, National Institute of Biomedical Innovation, Health and Nutrition
2021-2022 Special Researcher, National Institute of Biomedical Innovation, Health and Nutrition
2022- Section Head, National Institute of Biomedical Innovation, Health and Nutrition

Research History 12

2024/10 - Present

Tohoku University　Medicine and Science in Sports and Exercise, Graduate School of Medicine　Professor
2024/10 - Present

Tohoku University　Sports and Health Sciences, Graduate School of Biomedical Engineering　Professor
2024/10 - Present

National Institutes of Biomedical Innovation, Health and Nutrition　Center for Physical Activity Research　Visiting Researcher
2022/10 - 2024/09

National Institutes of Biomedical Innovation,Health and Nutrition　Department of Physical Activity Research, Section of Exercise Guideline　Section Head
2021/04 - 2022/09

National Institutes of Biomedical Innovation,Health and Nutrition　Special Researcher
2019/04 - 2021/03

National Institutes of Biomedical Innovation, Health and Nutrition　Associate Researcher
2014/04 - 2019/03

National Institutes of Biomedical Innovation, Health and Nutrition　National Institute of Health and Nutrition　Researcher
2013/04 - 2014/03

University of Wisconsin-Madison　Nutritional Sciences　Visiting Research Fellow
2011/04 - 2014/03

Kyoto Prefectural University of Medicine　Lab. Sports and Health Science　JSPS Research Fellow (SPD)
2009/04 - 2011/03

Fukuoka University　Institute of Physical Activity　Post-doctoral Research Associate
2008/04 - 2009/10

University of Wisconsin-Madison　Nutritional Sciences　Visiting Research Fellow
2007/04 - 2009/03

Kyoto University　Graduate School of Human and Environmental Studies　JSPS Research Fellow (DC-2)

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Education 3

Kyoto University　Graduate School of Human and Environmental Studies

2003/04 - 2008/03
Kyoto University　Faculty of Integrated Human Studies

1999/04 - 2003/03
Saitama Prefectural Urawa High School

1996/04 - 1999/03

Committee Memberships 9

日本カヘキシア・サルコペニア学会　評議員

2024/10 - Present
日本体力医学会　評議員

2024/10 - Present
IAEA DLW Database　Management Group

2014/10 - Present
厚生労働省「日本人のための食事摂取基準2025」策定ワーキンググループ委員　山田陽介

2023 - 2024/03
京都府亀岡市　WHO-CC セーフコミュニティ認証高齢者安全対策委員

2012/04 - 2013/03
Vice president, International Doubly Labeled Water Workshop

2014/10 -
International Doubly Labeled Water Workshop　運営委員, 講師

2010/10 -
日本セーフティプロモーション学会　第1回大会実行委員

2007/09 -
ランニング学会　第19回大会実行委員

2007/03 -

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Professional Memberships 13

European College of Sport Science
日本公衆衛生学会
Gerontological Society of America
American College of Sports Medicine
日本体育学会
日本体力医学会
Japanese Society of Aerospace and Environmental Medicine
Japan Society of Physiological Anthropology
Japanese Society of Public Health
American Society for Nutrition
Health and Sports Sciences
Japan Society of Physical Education
Japanese Society of Physical Fitness and Sports Medicine

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Research Interests 13

physical activity
Nutrition
Kinesiology
Motor Control and Biomechanics
Sport Nutrition
Frailty
Gerontology
Exercise Physiology
Physical Fitness and Sports Medicine
Skeletal Muscle
Sarcopenia
Energy Metabolism
Body Composition

Research Areas 5

Life sciences / Metabolism and endocrinology /
Life sciences / Healthcare management, medical sociology /
Life sciences / Physiology /
Life sciences / Nutrition and health science /
Life sciences / Sports science /

Awards 8

The 21st JSPS Prize

2024/12　Japan Society for the Promotion of Science
International partnership for young scientist

2023/12　Chinese Academy of Sciences
Editor's Choice Article in March 2017

2017/03　Journal of Gerontology Biological Sciences
Young Investigator Award

2014/02　International Osteoporosis Foundation and International Society for Clinical Densitometry Joint Meeting, Skeletal Health
Young Investigator Award

2013/12　7th International Conference of the Society on Sarcopenia, Cachexia and Wasting Disorders
Most Excellence Article in 2009

2010/10　Japanese Journal of Physiological Anthropology
Award for 65th Anniversary Celebration Article in Journal of Gerontology

2010/05　The Gerontological Society of America
Most Valuable Presentation of Young Researcher

2007/03　Kyoto Society of Physical Education, Health and Sports Sciences

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Papers 385

Economic Deterioration and Social Factors Affecting Mental Health During the COVID-19 Pandemic in Japan: Web-Based Cross-Sectional Survey

Kentaro Hori, Yosuke Yamada, Hideyuki Namba, Misaka Kimura, Hiroyuki Fujita, Heiwa Date

JMIR Formative Research　2025/06/10

DOI： 10.2196/65204 　
Author Correction: Predictive equation derived from 6,497 doubly labelled water measurements enables the detection of erroneous self-reported energy intake

Rania Bajunaid, Chaoqun Niu, Catherine Hambly, Zongfang Liu, Yosuke Yamada, Heliodoro Aleman-Mateo, Liam J. Anderson, Lenore Arab, Issad Baddou, Linda Bandini, Kweku Bedu-Addo, Ellen E. Blaak, Carlijn V. C. Bouten, Soren Brage, Maciej S. Buchowski, Nancy F. Butte, Stefan G. J. A. Camps, Regina Casper, Graeme L. Close, Jamie A. Cooper, Richard Cooper, Sai Krupa Das, Peter S. W. Davies, Prasangi Dabare, Lara R. Dugas, Simon Eaton, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Melanie Gillingham, Annelies H. Goris, Michael Gurven, Asmaa El Hamdouchi, Hinke H. Haisma, Daniel Hoffman, Marije B. Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M. Joosen, Peter Katzmarzyk, Misaka Kimura, William E. Kraus, Wantanee Kriengsinyos, Rebecca Kuriyan, Robert F. Kushner, Estelle V. Lambert, Pulani Lanerolle, Christel L. Larsson, William R. Leonard, Nader Lessan, Marie Löf, Corby K. Martin, Eric Matsiko, Anine C. Medin, James C. Morehen, James P. Morton, Aviva Must, Marian L. Neuhouser, Theresa A. Nicklas, Christine D. Nyström, Robert M. Ojiambo, Kirsi H. Pietiläinen, Yannis P. Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L. Prentice, Susan B. Racette, David A. Raichlen, Eric Ravussin, Leanne M. Redman, John J. Reilly, Rebecca Reynolds, Susan B. Roberts, Dulani Samaranayakem, Luis B. Sardinha, Analiza M. Silva, Anders M. Sjödin, Marina Stamatiou, Eric Stice, Samuel S. Urlacher, Ludo M. Van Etten, Edgar G. A. H. van Mil, George Wilson, Jack A. Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J. Murphy-Alford, Srishti Sinha, Cornelia U. Loechl, Amy H. Luke, Herman Pontzer, Jennifer Rood, Hiroyuki Sagayama, Dale A. Schoeller, Klaas R. Westerterp, William W. Wong, John R. Speakman

Nature Food　2025/04/23

DOI： 10.1038/s43016-025-01175-2 　
Associations of Moderate-to-vigorous Physical Activity and Sitting Time With Risk of Disability and Mortality Among Japanese Older Adults

Daiki Watanabe, Tsukasa Yoshida, Yuya Watanabe, Yosuke Yamada, Motohiko Miyachi, Misaka Kimura

Journal of Epidemiology　2025

DOI： 10.2188/jea.JE20240385 　
Effects of muscle quantity, muscle quality, and phase angle on whole-body reaction time in 5164 adults aged 20–91 years

Wataru Fukuda, Takeshi Yoshihisa, Yosuke Yamada

European Journal of Applied Physiology　2025/01

DOI： 10.1007/s00421-024-05591-3 　
Association of the interaction between daily step counts and frailty with disability in older adults. International-journal

Daiki Watanabe, Tsukasa Yoshida, Yuya Watanabe, Yosuke Yamada, Motohiko Miyachi, Misaka Kimura

GeroScience　2024/12/21

DOI： 10.1007/s11357-024-01471-y 　

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The differences in the association of objectively measured physical activity with disability between frail and non-frail older adults remain unclear. We (1) evaluated the dose-dependent relationship between daily steps and disability in older adults with and without frailty and (2) examined the interaction between steps and frailty status in relation to the risk of disability. This prospective study used data from 4065 adults aged ≥ 65 years from the Kyoto-Kameoka Study, Japan. The mean daily step count obtained using triaxial accelerometers across ≥ 4 days was recorded. Frailty was evaluated using the validated Kihon Checklist. Disability was identified using the long-term care insurance system's nationally unified database, with data collected until November 30, 2016. Overall, 385 disabilities were recorded during a median follow-up period of 3.32 years (12,855 person-years). After adjusting for confounders, an inverse association was observed between daily step count and disability risk. The disability risk plateaued at 5,000-7,000 steps/day in non-frail people, whereas step counts showed an almost linear inverse relationship with disability risk in frail people. Low step counts (< 5,000 steps) in frail people were more strongly associated with disability risk than were high step counts (≥ 5,000 steps) in non-frail people. The additive interaction between steps and frailty was associated with the relative excess risk of disability in frail people with low step counts (p for interaction = 0.015). The relationship between daily steps and disability differs between older adults with and without frailty, and the adverse effects of frailty on disability risk depend on physical activity.
BMI trajectory of 8,155,894 Japanese adults from exhaustive health checkup data: the contributions of age-related changes in height and weight. International-journal

Naoki Uemura, Yuki Nishida, Satoshi Sasaki, Yosuke Yamada, Tatsuhiko Anzai, Kunihiko Takahashi, Keita Yamauchi, Fuminori Katsukawa

International journal of obesity (2005)　2024/12/18

DOI： 10.1038/s41366-024-01694-1 　

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This study aimed to clarify the trajectory of BMI alongside age-related changes in height and weight among Japanese adults. Data from annual health checkups between 2015 and 2020 by the Japan Health Insurance Association were retrospectively analyzed. A total of 4,777,891 men and 3,378,003 women (age 35-69 years) were stratified into 14 subgroups based on sex and 5-year age categories. We used linear mixed-effects model to estimate values for each outcome, with six-time points (2015-2020) as the independent variable. Mean BMI changes were positive across all subgroups, indicating a trend of increasing BMI (men, 0.02 to 0.14 kg/m2/year; women, 0.05 to 0.16 kg/m2/year). In younger subgroups, the changed were relatively large, with the weight transitions mirroring those of BMI. However, the mean changes were negative (men, -0.06 kg/year; women, -0.01 kg/year) in the oldest subgroups. Height reduction increased with age across subgroups (men, -0.14 to -0.03 cm/year; women, -0.18 to -0.01 cm/year). In conclusion, BMI tended to increase with age in both sexes across all age groups of Japanese adults. The increase in BMI appeared to be influenced by weight gain in young to middle age, whereas height reduction influenced increased BMI in older age groups.
Decline in Isotope Dilution Space Ratio Above Age 60 Could Affect Energy Estimates Using the Doubly Labeled Water Method

William W Wong, John R Speakman, Philip N Ainslie, Liam J Anderson, Leonore Arab, Issad Baddou, Kweku Bedu-Addo, Ellen E Blaak, Stephane Blanc, Alberto G Bonomi, Carlijn VC Bouten, Pascal Bovet, Maciej S Buchowski, Nancy F Butte, Stefan G Camps, Regina Casper, Graeme L Close, Lisa H Colbert, Jamie A Cooper, Sai K Das, Peter SW Davies, Simon Eaton, Ulf Ekelund, Catherine Hambly, Asmaa El Hamdouchi, Sonja Entringer, Barry W Fudge, Melanie Gillingham, Annelies H Goris, Micheal Gurven, Marije B Hoos, Sumei Hu, Annemiek Joosen, Peter T Katzmarzyk, Kitty P Kempen, Misaka Kimura, William E Kraus, Robert F Kushner, Christel L Larsson, James C Morehen, James P Morton, Marian L Neuhouser, Theresa A Nicklas, Robert M Ojiambo, Kirsi H Pietilainen, Yannis P Pitsiladis, Guy Plasqui, Ross L Prentice, Roberto Rabinovich, Susan B Racette, David A Raichen, Leanne Redman, Eric Ravussin, John J Reilly, Susan Roberts, Albertine J Scuitt, Anders M Sjödin, Eric Stice, Samuel S Urlacher, Giulio Valenti, Ludo M van Etten, Edgar A Van Mil, Jeanine A Verbunt, Jonathan CK Wells, George Wilson, Tsukasa Yoshida, Xueying Zhang, Cornelia U Loechl, Amy Luke, Alexia J Murphy-Alford, Herman Pontzer, Hiroyuki Sagayama, Jennifer C Rood, Dale A Schoeller, Klaas R Westerterp, Yosuke Yamada

The Journal of Nutrition　154　(12)　3824-3831　2024/12
Publisher: Elsevier BV
DOI： 10.1016/j.tjnut.2024.10.016 　

ISSN： 0022-3166
MOTS-c modulates skeletal muscle function by directly binding and activating CK2. International-journal

Hiroshi Kumagai, Su-Jeong Kim, Brendan Miller, Hirofumi Zempo, Kumpei Tanisawa, Toshiharu Natsume, Shin Hyung Lee, Junxiang Wan, Naphada Leelaprachakul, Michi Emma Kumagai, Ricardo Ramirez 2nd, Hemal H Mehta, Kevin Cao, Tae Jung Oh, James A Wohlschlegel, Jihui Sha, Yuichiro Nishida, Noriyuki Fuku, Shohei Dobashi, Eri Miyamoto-Mikami, Mizuki Takaragawa, Mizuho Fuku, Toshinori Yoshihara, Hisashi Naito, Ryoko Kawakami, Suguru Torii, Taishi Midorikawa, Koichiro Oka, Megumi Hara, Chiharu Iwasaka, Yosuke Yamada, Yasuki Higaki, Keitaro Tanaka, Kelvin Yen, Pinchas Cohen

iScience　27　(11)　111212-111212　2024/11/15

DOI： 10.1016/j.isci.2024.111212 　

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MOTS-c is a mitochondrial microprotein that improves metabolism. Here, we demonstrate CK2 is a direct and functional target of MOTS-c. MOTS-c directly binds to CK2 and activates it in cell-free systems. MOTS-c administration to mice prevented skeletal muscle atrophy and enhanced muscle glucose uptake, which were blunted by suppressing CK2 activity. Interestingly, the effects of MOTS-c are tissue-specific. Systemically administered MOTS-c binds to CK2 in fat and muscle, yet stimulates CK2 activity in muscle while suppressing it in fat by differentially modifying CK2-interacting proteins. Notably, a naturally occurring MOTS-c variant, K14Q MOTS-c, has reduced binding to CK2 and does not activate it or elicit its effects. Male K14Q MOTS-c carriers exhibited a higher risk of sarcopenia and type 2 diabetes (T2D) in an age- and physical-activity-dependent manner, whereas females had an age-specific reduced risk of T2D. Altogether, these findings provide evidence that CK2 is required for MOTS-c effects.
Is a higher body mass index associated with longer duration of survival with disability in frail than in non-frail older adults?

Daiki Watanabe, Tsukasa Yoshida, Yuya Watanabe, Yosuke Yamada, Misaka Kimura

International Journal of Obesity　2024/11/15
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s41366-024-01681-6 　

ISSN： 0307-0565

eISSN： 1476-5497

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Abstract Background/Objectives This study investigated the hitherto unclear association of body mass index (BMI) with age at overall, disability, and disability-free survival in older adults with and without frailty. Methods This prospective cohort study enroled 10232 Japanese adults aged ≥65 years, who underwent follow-up for adverse events, from the Kyoto-Kameoka Study conducted from 2011–2016. BMI, calculated based on self-reported height and body weight, was classified into five categories: <18.5, 18.5–21.4, 21.5–24.9, 25.0–27.4, and ≥27.5 kg/m². Frailty was assessed using the validated Kihon Checklist. The relationships between BMI and disability and mortality were analysed using multivariate Cox proportional hazards models and Laplace regression. Results During the 5.3-year median follow-up period (45472 person-years), 2348 (22.9%) incidences of disabilities occurred. After adjusting for confounders, including medical history and lifestyle, individuals in the lowest and highest BMI categories had a higher hazard ratio (HR) of disability [<18.5 kg/m²: HR: 1.31, confidence interval (CI): 1.16–1.49; ≥27.5 kg/m²: HR: 1.27, 95% CI: 1.08–1.49, p for non-linearity <0.001] compared with that of those with BMI = 21.5–24.9 kg/m². In the 50th percentile differences in age at overall and disability-free survival, participants with BMI < 18.5 kg/m² were more likely to die before disability incidence [survival with disability (overall survival – disability-free survival): −10.2 months]; those with BMI ≥ 27.5 kg/m² had longer survival with disability (12.5 months). These relationships were more marked in the frailty-stratified model, where in the BMI ≥ 27.5 kg/m² group, individuals with frailty survived longer with disability (27.2 months) than did individuals without frailty (6.2 months). Conclusion Higher BMI is associated with a longer duration of survival with disability among older adults, especially in those with frailty. Therefore, reversing frailty should be prioritised because individuals with frailty have a shorter probability of disability-free survival than do individuals without frailty, regardless of BMI.
[A review of the literature on sedentary behavior].

Mikako Yasuoka, Takashi Nakagata, Yosuke Yamada, Koichiro Oka, Shigeru Inoue, Rei Ono

[Nihon koshu eisei zasshi] Japanese journal of public health　2024/11/08

DOI： 10.11236/jph.24-057 　

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Sedentary behavior (such as sitting, watching TV, and driving) is characterized by little physical movement and low energy expenditure (≤1.5 metabolic equivalents). Previous studies have shown associations between sedentary behavior and adverse outcomes, including cancer, cardiovascular disease, and death. This study is a narrative review that aims to summarize the assessment tools for sedentary behavior as well as the association between sedentary behavior and adverse health outcomes. Additionally, guidelines for future research on sedentary behavior are discussed.Sedentary behavior is assessed using subjective methods such as questionnaire responses or objective methods such as accelerometer readings. Although questionnaire methods have low validity, they allow researchers to collect information regarding the purpose or occasion of physical activity at a low cost. Accelerometers are expensive but collect precise information on the duration of sedentary behavior. Sedentary behavior is a risk factor for the incidence of cardiovascular diseases and cancer and associated mortality. The association between sedentary behavior and some diseases such as cancer type have been reported. Previous studies have found a dose-response relationship between sedentary time and adverse outcomes. Research on the associations between sedentary behavior and the subtypes of stroke, heart disease, and orthopedic diseases is insufficient; further studies are needed to clarify these associations. Recently, sedentary behavior has been the focus of guidelines in some countries because of increasing evidence on its adverse consequences. Intervention studies have shown that taking breaks and replacing sedentary behavior with vigorous or high-intensity physical activity benefit the health of participants. Future studies are needed to examine the cutoff values of sitting time that reduce the risk of morbidity for each disease and the health effects of interventions that shorten sitting time.
Determinant of factors associated with water requirement measured using the doubly labelled water method among older Japanese adults

Daiki Watanabe, Tsukasa Yoshida, Hinako Nanri, Aya Itoi, Chiho Goto, Kazuko Ishikawa-Takata, Naoyuki Ebine, Yasuki Higaki, Motohiko Miyachi, Misaka Kimura, Yosuke Yamada

Public Health Nutrition　27　(1)　2024/09/26
Publisher: Cambridge University Press (CUP)
DOI： 10.1017/s1368980024001587 　

ISSN： 1368-9800

eISSN： 1475-2727

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Abstract Objective: Water is an essential nutrient for all organisms and is important for maintaining life and health. We aimed to develop a biomarker-calibrated equation for predicting water turnover (WT) and pre-formed water (PW) using the doubly labelled water (DLW) method. Design: Cross-sectional study. Setting: General older population from the Kyoto–Kameoka Study, Japan. Participants: The 141 participants aged ≥ 65 years were divided into a model developing (n 71) and a validation cohort group (n 70) using a random number generation. WT and PW was measured using the DLW method in May–June of 2012. In developing the cohort, equations for predicting WT and PW were developed by multivariate stepwise regression using all data from the questionnaires in the Kyoto–Kameoka study (including factors such as dietary intake and personal characteristics). WT and PW measured using the DLW method were compared with the estimates from the regression equations developed using the Wilcoxon signed-rank test and correlation analysis in validation cohort. Results: The median WT and PW for 141 participants were 2·81 and 2·28 l/d, respectively. In the multivariate model, WT (R² = 0·652) and PW (R² = 0·623) were moderately predicted using variables, such as height, weight and fluid intake from beverages based on questionnaire data. WT (r = 0·527) and PW (r = 0·477) predicted that using this model was positively correlated with the values measured by the DLW method. Conclusions: Our results showed factors associated with water requirement and indicated a methodological approach of calibrating the self-reported dietary intake data using biomarkers of water consumption.
Life-Space Mobility and Frailty in Older Japanese Adults: A Cross-Sectional Study. International-journal

Atsuko Tanide, Daiki Watanabe, Tsukasa Yoshida, Yosuke Yamada, Yuya Watanabe, Minoru Yamada, Hiroyuki Fujita, Tomoki Nakaya, Motohiko Miyachi, Masaru Watanabe, Yoshinori Fujiwara, Hidenori Arai, Misaka Kimura

Journal of the American Medical Directors Association　105232-105232　2024/08/29

DOI： 10.1016/j.jamda.2024.105232 　

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OBJECTIVES: Some studies reported a relationship between life-space mobility (LSM) and frailty assessed by physical aspects; however, a more comprehensive discussion of frailty is underdeveloped. In addition, previous studies have focused only on older Euro-American people. Therefore, we aimed to examine LSM-frailty relationships in community-dwelling older Japanese persons using physical and comprehensive frailty indices. DESIGN: A cross-sectional study. SETTING AND PARTICIPANTS: We used the data of 8898 older adults from a baseline survey of the Kyoto-Kameoka Study in Japan. METHODS: The validated life-space assessment (LSA) was used to evaluate LSM and categorized it into quartiles. Two validated indices were used to evaluate frailty: the Kihon Checklist (KCL) and the simple Frailty Screening Index (FSI). Multivariable logistic regression was used to determine the relationships between LSM scores and frailty. RESULTS: The mean age (SD) of the participants was 73.4 (6.3) years, and 53.3% were women. The mean LSM score of the study participants was 53.0. The prevalence of frailty by KCL and FSI was 40.7% and 16.8%, respectively. Significant differences between LSM score and frailty prevalence were observed [KCL: Q1, reference; Q2, odds ratio (OR) 0.53, 95% CI 0.45-0.62; Q3, OR 0.30, 95% CI 0.25-0.35; Q4: OR 0.22, 95% CI 0.18-0.26, P for trend <.001; FSI: Q1, reference; Q2, OR 0.57, 95% CI 0.48-0.68; Q3: OR 0.38, 95% CI 0.31-0.46; Q4: OR 0.35, 95% CI 0.28-0.42, P for trend <.001]. Similar results were observed when LSM scores were examined at 10-point intervals, with LSM and frailty exhibiting an L-shaped relationship. The LSM score dose-response curve at which the OR for frailty plateaued among older individuals was approximately 81-90 score. CONCLUSIONS AND IMPLICATIONS: LSM score and frailty prevalence exhibited L-shaped relationships in community-dwelling older persons. This study's findings provide useful data for setting LSM targets for preventing frailty in community-dwelling older persons.
Factors associated with water consumption measured using the stable isotope techniques among Japanese adults: a cross-sectional study. International-journal

Daiki Watanabe, Rie Tomiga-Takae, Jun Yasukata, Yujiro Kose, Takaaki Komiyama, Yuki Tomiga, Eiichi Yoshimura, Yosuke Yamada, Naoyuki Ebine, Motohiko Miyachi, Yoichi Hatamoto, Yasuki Higaki

European journal of clinical nutrition　2024/08/28

DOI： 10.1038/s41430-024-01481-1 　

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BACKGROUND/OBJECTIVES: While some dietary guidelines have established daily water requirements for adults, those for older adults are not well defined. Factors associated with water turnover (WT), indicating water requirements and preformed water (PW), referring to fluids consumed from food and beverages, remain poorly understood. Therefore, we aimed to investigate these factors in Japanese adults. SUBJECTS/METHODS: This cross-sectional study included 57 participants aged 54-85 years, living in Fukuoka City, Japan. The WT and PW were measured using the doubly labelled water (DLW) methods from August 2015 to September 2015. Dietary intake and physical activity were evaluated using a 3-day dietary record (DR) and a validated triaxial accelerometer, respectively. Fasting blood and urine samples, as well as environmental conditions, were assessed using a validated technique. We evaluated the variables for predicting water consumption by using a multivariate generalised linear model, with forward stepwise selection using these covariates. RESULTS: The median WT and PW were 2842 ml/day and 2227 ml/day, respectively. In the multivariate model, WT (R2 = 0.629) and PW (R2 = 0.621) were moderately predicted by variables such as sex, body weight, moderate-to-vigorous physical activity, water consumption estimated by DR, urinary aldosterone and osmolality, creatinine clearance and wet-bulb globe temperature. The PW estimates from DR were ~40% lower than those from DLW method, despite a significant correlation between the values. CONCLUSIONS: WT and PW are associated not only with lifestyle and environmental factors but also with urinary markers and kidney function. These findings provide useful insights into the differences in each individual's water requirement.
Comparison of step-count outcomes across seven different activity trackers: a free-living experiment with young and older adults. International-journal

Takashi Nakagata, Yosuke Yamada, Masashi Taniguchi, Hinako Nanri, Misaka Kimura, Motohiko Miyachi, Rei Ono

BMC sports science, medicine & rehabilitation　16　(1)　156-156　2024/07/18

DOI： 10.1186/s13102-024-00943-0 　

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BACKGROUND: There are now many different types of activity trackers, including pedometers and accelerometers, to estimate step counts per day. Previous research has extensively examined step-count measurements using activity trackers across various settings while simultaneously wearing different devices.; however, older adults frequently display distinct walking patterns and gait speeds compared to younger adults. This study aimed to compare the step-count between older and younger adults by having them simultaneously wear seven different activity trackers in free-living experiments. METHODS: This study included 35 younger adults (21-43 yrs) and 57 physically independent older adults (65-91 yrs). All participants simultaneously wore one pedometer and six activity trackers: ActiGraph GT3X + Wrist and Hip, Omron Active Style Pro HJA-350IT, Panasonic Actimarker, TANITA EZ-064, Yamasa TH-300, and Yamasa AS-200 for seven days. A regression equation was also used to assess inter-device compatibility. RESULTS: When comparing wrist-worn ActiGraph to the six hip-worn activity trackers, the wrist-worn ActiGraph consistently recorded step counts over 4,000 steps higher than hip-worn activity trackers in both groups (range, 3000-5000 steps). Moreover, when comparing the ActiGraph worn on the wrist to that worn on the hip, the proportion was higher among older adults compared to younger ones (younger: 131%, older: 180%). The Actimarker recorded the highest average step counts among six hip-worn devices, with 8,569 ± 4,881 overall, 9,624 ± 5,177 for younger adults, and 7,890 ± 4,562 for older adults. The difference between the hip-worn ActiGraph and Active Style Pro was just about 70 steps/day overall. The correlation among all devices demonstrated a very high consistency, except for the wrist-worn ActiGraph (r = 0.874-0.978). CONCLUSIONS: Step counts recorded from seven selected consumer-based and research-grade activity trackers and one pedometer, except for the wrist-worn ActiGraph. showed a variation of approximately 1700 steps (range, 1265-2275 steps) steps for both groups, yet maintained a high correlation with each other. These findings will be valuable for researchers and clinicians as they compare step counts across different studies or representative surveys conducted globally.
Oral frailty is associated with mortality independently of physical and psychological frailty among older adults. International-journal

Daiki Watanabe, Tsukasa Yoshida, Yuya Watanabe, Keiichi Yokoyama, Yosuke Yamada, Takeshi Kikutani, Mitsuyoshi Yoshida, Motohiko Miyachi, Misaka Kimura

Experimental gerontology　191　112446-112446　2024/06/15

DOI： 10.1016/j.exger.2024.112446 　

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BACKGROUND: Although oral frailty is independently associated with an increased risk of mortality, evidence for the usefulness of screening tools for oral frailty is less than that for physical frailty screening tools. We aimed to investigate the relationship between oral frailty and mortality in older adults. METHODS: This prospective cohort study included 11,374 adults aged ≥65 years, who provided valid responses to a baseline mail survey questionnaire from the Kyoto-Kameoka study. Oral frailty status was evaluated using the Oral Frailty Index-8 (range, 0 [best] to 10 [worst]). Participants were classified into four categories according to the Oral Frailty Index-8: robust (score, 0-2), oral pre-frailty (score, 3), oral frailty (score, 4-6), and oral severe frailty (score ≥ 7). Physical and psychological frailty were evaluated using the validated frailty-screening index and defined as a score of ≥3 out of a possible 5 points. Mortality data were collected from 30 July 2011 to 30 November 2016. Hazard ratios (HR) for all-cause mortality were calculated using a multivariable Cox proportional hazards model. RESULTS: During the 5.3-year median follow-up period (57,157 person-years), 1184 deaths were recorded. After adjusting for confounders, including physical and psychological frailty, medical history, and lifestyle, in comparison with a robust oral status, oral pre-frailty (HR, 1.29; 95 % confidence interval [CI], 1.02-1.63), oral frailty (HR, 1.22; 95 % CI, 1.01-1.48), and oral severe frailty (HR, 1.43; 95 % CI, 1.16-1.76) were associated with higher HRs of mortality (p for trend = 0.002). CONCLUSION: Oral frailty is associated with mortality independent of physical and psychological frailty in older adults. The Oral Frailty Index-8 may be useful for identifying individuals at high risk of mortality.
Predictors of Water Turnover in Older Adults: A Doubly Labeled Water- and Triaxial Accelerometer-Based Study

Hyeon-Ki Kim, Hiroyuki Sagayama, Tsukasa Yoshida, Kan Oishi, Yui Nakayama, Misaka Kimura, Rei Ono, Yosuke Yamada

The Journal of Nutrition　2024/06

DOI： 10.1016/j.tjnut.2024.04.023 　
Home-based resistance training performed at either fast or slow speeds improves power output in older adults

Kosuke Hirata, Mari Ito, Yuta Nomura, Chiho Kawashima, Tsukasa Yoshida, Yosuke Yamada, Neale A. Tillin, Geoffrey A. Power, Ryota Akagi

Experimental Gerontology　190　112430-112430　2024/06
Publisher: Elsevier BV
DOI： 10.1016/j.exger.2024.112430 　

ISSN： 0531-5565
地域在住高齢者のドメイン別の行動時間と身体活動指数との関連

安岡実佳子, 山田陽介, 吉田司, 渡邊裕也, 木村みさか, 小野玲

日本老年医学会雑誌　61　(Suppl.)　185-185　2024/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
【健康づくりのための身体活動・運動ガイド2023】身体活動・運動ガイドの歴史と変遷

山田陽介, 宮地元彦, 小野玲

臨床栄養　144　(5)　618-623　2024/05
Publisher: 医歯薬出版(株)
ISSN： 0485-1412
Frailty modifies the association of body mass index with mortality among older adults: Kyoto-Kameoka study. International-journal

Daiki Watanabe, Tsukasa Yoshida, Yuya Watanabe, Yosuke Yamada, Motohiko Miyachi, Misaka Kimura

Clinical nutrition (Edinburgh, Scotland)　43　(2)　494-502　2024/01/04

DOI： 10.1016/j.clnu.2024.01.002 　

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BACKGROUND & AIMS: The differences in the association of body mass index (BMI) with mortality between older adults with and without frailty remain unclear. This study investigated this association in community-dwelling older adults with and without frailty. METHODS: This prospective study included 10,912 adults aged ≥65 years who provided valid responses to a baseline mail survey questionnaire in the Kyoto-Kameoka Study in Japan. The BMI was calculated based on self-reported height and body weight and classified into four categories: <18.5, 18.5-21.4, 21.5-24.9, and ≥25.0 kg/m2. Frailty was evaluated using the validated Kihon Checklist and defined as a score of 7 or higher out of a possible 25 points. Mortality data were collected from 30 July 2011 to 30 November 2016. Hazard ratios (HR) for all-cause mortality were calculated using a multivariable Cox proportional hazards model. RESULTS: During the 5.3 year median follow-up period (54,084 person-years), 1352 deaths were recorded. After adjusting for confounders, including lifestyle and medical history, compared with participants with a BMI of 21.5-24.9 kg/m2, those in the lower BMI category had a higher mortality HR, while those with a higher BMI displayed an inverse association with mortality (<18.5 kg/m2: HR: 1.85, 95% confidence interval [CI]: 1.58-2.17; 18.5-21.4 kg/m2: HR: 1.38, 95% CI: 1.21-1.58; and ≥25.0 kg/m2: HR: 0.80, 95% CI: 0.67-0.96). In a model stratified by frailty status, the BMI range with the lowest HR for mortality was 23.0-24.0 kg/m2 in non-frail older adults; however, in frail older adults, a higher BMI was inversely associated with mortality. CONCLUSIONS: The relationship between BMI and mortality varies between individuals with and without frailty, with those experiencing frailty potentially benefiting from a higher BMI compared to those without frailty. This study suggests that frailty should be assessed when considering the optimal BMI for the lowest mortality risk among older adults.
Association between doubly labelled water-calibrated energy intake and objectively measured physical activity with mortality risk in older adults. International-journal

Daiki Watanabe, Tsukasa Yoshida, Yuya Watanabe, Yosuke Yamada, Motohiko Miyachi, Misaka Kimura

The international journal of behavioral nutrition and physical activity　20　(1)　150-150　2023/12/25

DOI： 10.1186/s12966-023-01550-x 　

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BACKGROUND: Physical activity or biomarker-calibrated energy intake (EI) alone is associated with mortality in older adults; the interaction relationship between the combined use of both factors and mortality has not been examined. We evaluated the relationship between mortality and calibrated EI and step counts in older adults. METHODS: This prospective study included 4,159 adults aged ≥65 years who participated in the Kyoto-Kameoka study in Japan and wore a triaxial accelerometer between 1 April and 15 November 2013. The calibrated EI was calculated based on a previously developed equation using EI biomarkers. The step count was obtained from the accelerometer ≥ 4 days. Participants were classified into the following four groups: low EI (LEI)/low step counts (LSC) group (EI: <2,400 kcal/day in men and <1,900 kcal/day in women; steps: <5,000 /day), n = 1,352; high EI (HEI)/LSC group (EI: ≥2,400 kcal/day in men and ≥1,900 kcal/day in women; steps: <5,000 /day), n = 1,586; LEI/high step counts (HSC) group (EI: <2,400 kcal/day in men and < 1,900 kcal/day in women; steps: ≥5,000 /day), n = 471; and HEI/HSC group (EI: ≥2,400 kcal/day in men and ≥1,900 kcal/day in women; steps: ≥5,000 /day), n = 750. Mortality-related data were collected until 30 November 2016. We performed a multivariable Cox proportional hazard analysis. RESULTS: The median follow-up period was 3.38 years (14,046 person-years), and 111 mortalities were recorded. After adjusting for confounders, the HEI/HSC group had the lowest all-cause mortality rate compared to other groups (LEI/LSC: reference; HEI/LSC: hazard ratio [HR]: 0.71, 95% confidence interval [CI]: 0.41-1.23; LEI/HSC: HR: 0.59, 95% CI: 0.29-1.19; and HEI/HSC: HR: 0.10, 95% CI: 0.01-0.76). No significant interaction was observed between the calibrated EI and steps with mortality. The spline model showed that 35-42 kcal/100 steps/day of EI/100 steps was associated with the lowest mortality risk. CONCLUSIONS: HR mortality risk was lowest at 35-42 kcal/100 steps/day, suggesting that very high (≥56 kcal) or low (<28 kcal) EI/100 steps are not inversely associated with mortality. Adherence to optimal EI and adequate physical activity may provide sufficient energy balance to explain the inverse association with mortality among older Japanese adults.
Age‐related change in gait efficacy and predictors of its decline: A 3‐year longitudinal study

Yu Sato, Masashi Taniguchi, Yoshihiro Fukumoto, Shogo Okada, Zimin Wang, Kaede Nakazato, Nanami Niiya, Yosuke Yamada, Misaka Kimura, Noriaki Ichihashi

Geriatrics & Gerontology International　2023/12/16
Publisher: Wiley
DOI： 10.1111/ggi.14767 　

ISSN： 1444-1586

eISSN： 1447-0594

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Aim This study aimed to calculate the minimal clinically important difference (MCID) for a modified Gait Efficacy Scale (mGES) over 3 years and to clarify the predictors of mGES decline. Methods In total, 87 community‐dwelling older adults were enrolled in this 3‐year longitudinal study. The mGES, fall history and physical function (chair stand frequency, open‐eyes one‐leg stand, open–close stepping test, walking speed, walking endurance [shuttle stamina walk test] and physical activity) were assessed at baseline. After a 3‐year follow‐up period, the mGES and Global Rating of Change Scale were assessed. The MCID was calculated using anchor‐based methods, with the Global Rating of Change Scale as an anchor. The participants were classified into the decline and keep groups based on whether the changes in the mGES were greater than the MCID. A logistic regression analysis was conducted using the mGES as the dependent variable and physical characteristics, fall history, and physical function as independent variables. Results The MCID for the mGES over 3 years was −7.38 points. A logistic regression analysis identified low open–close stepping (odds ratio, 0.87; 95% confidence interval, 0.782–0.985; P = 0.027) and the shuttle stamina walk test (odds ratio, 0.974; 95% confidence interval, 0.949–1.000; P = 0.049) as predictors of the mGES decline. Conclusion These findings suggest that a change of 7.38 points in the mGES was clinically significant and that poor agility and walking endurance can predict future decline in the mGES. Geriatr Gerontol Int 2023; ••: ••–••.
Association of skeletal muscle function, quantity, and quality with gut microbiota in Japanese adults: A cross-sectional study.

Chiharu Iwasaka, Hinako Nanri, Takashi Nakagata, Harumi Ohno, Kumpei Tanisawa, Kana Konishi, Haruka Murakami, Koji Hosomi, Jonguk Park, Yosuke Yamada, Rei Ono, Kenji Mizuguchi, Jun Kunisawa, Motohiko Miyachi

Geriatrics & gerontology international　2023/12/14

DOI： 10.1111/ggi.14751 　

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AIM: The gut microbiota has emerged as a new intervention target for sarcopenia. Prior studies in humans have focused on the association between gut microbiota and skeletal muscle quantity, while the evidence on muscle function and quality is lacking. This study aimed to identify gut microbiota genera associated with skeletal muscle function, quantity, and quality in a general population of Japanese adults. METHODS: This cross-sectional study included 164 participants aged 35-80 years, women and men recruited from urban areas of Japan. Fecal samples were collected and analyzed using 16S rRNA gene amplicon sequencing. Skeletal muscle function was measured using handgrip strength and leg extension power (LEP), while skeletal muscle mass was estimated using bioelectrical impedance analysis. Phase angle was used as a measure of skeletal muscle quality. Multivariate linear regression analysis stratified by age group was used to examine the association between the dominant genera of the gut microbiota and skeletal muscle variables. RESULTS: A significant association was found between Bacteroides and Prevotella 9 with LEP only in the ≥60 years group. When both Bacteroides and Prevotella 9 were included in the same regression model, only Bacteroides remained consistently and significantly associated with LEP. No significant associations were observed between skeletal muscle mass, handgrip strength, and phase angle and major gut microbiota genera. CONCLUSIONS: In this study, we observed a significant positive association between Bacteroides and leg muscle function in older adults. Further studies are required to elucidate the underlying mechanisms linking Bacteroides to lower-extremity muscle function. Geriatr Gerontol Int 2023; ••: ••-••.
Dose-Response Relationships between Diet Quality and Mortality among Frail and Non-Frail Older Adults: A Population-Based Kyoto-Kameoka Prospective Cohort Study

Daiki Watanabe, T. Yoshida, H. Nanri, Y. Watanabe, A. Itoi, C. Goto, K. Ishikawa-Takata, Y. Yamada, H. Fujita, M. Miyachi, M. Kimura

The journal of nutrition, health & aging　2023/11/30
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s12603-023-2041-7 　

eISSN： 1760-4788
Relation of leg phase angle from bioelectrical impedance analysis with voluntary and evoked contractile properties of the plantar flexors

Kosuke Hirata, Yosuke Yamada, Natsuki Iida, Akihiro Kanda, Mikio Shoji, Tsukasa Yoshida, Ryota Akagi

Frontiers in Physiology　14　2023/11/23
Publisher: Frontiers Media SA
DOI： 10.3389/fphys.2023.1292778 　

eISSN： 1664-042X

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Introduction: Bioelectrical impedance analysis (BIA) can noninvasively and quickly assess electrical properties of the body, such as the phase angle. Phase angle is regarded as the quantity and/or quality of skeletal muscle and is associated with exercise performance, such as jump height and walking speed. Although the phase angle derived from BIA is assumed to be a useful way to assess muscle function, the relationship between the phase angle and neuromuscular properties has not been fully investigated. The purpose of this study was to investigate the association of phase angle with voluntary and evoked contractile properties in 60 adults (age, 21–83 years; 30 females and 30 males). Methods: The phase angle of the right leg at 50 kHz was evaluated using BIA. The twitch contractile properties (peak twitch torque [PT_twitch], rate of twitch torque development [RTD_twitch], and time-to-PT_twitch [TPT_twitch]) of the plantar flexors were measured using tibial nerve electrical stimulation. Maximal voluntary isometric contractions (MVICs) were performed to measure the maximal muscle strength and explosive muscle strength, from which the peak MVIC torque (PT_MVIC) and rate of torque development (RTD) over a time interval of 0–200 ms were assessed, respectively. The root mean square (RMS) values of electromyographic (EMG) activity during the PT_MVIC and RTD measurements (EMG-RMS_MVIC and EMG-RMS_RTD, respectively) were calculated. The RTD and EMG-RMS_RTD were normalized using PT_MVIC and EMG-RMS_MVIC, respectively. Results and discussion: Phase angle significantly correlated with twitch contractile properties (|r| ≥ 0.444, p &lt; 0.001), PT_MVIC (r = 0.532, p &lt; 0.001), and RTD (r = 0.514, p &lt; 0.001), but not with normalized RTD (r = 0.242, p = 0.065) or normalized EMG-RMS_RTD (r = −0.055, p = 0.676). When comparing measurement variables between the low- and high-phase angle groups while controlling for sex and age effects, the high-phase angle group showed greater PT_twitch, RTD_twitch, PT_MVIC, and RTD (p &lt; 0.001) and shorter TPT_twitch (p &lt; 0.001) but not normalized RTD (p = 0.184) or normalized EMG-RMS_RTD (p = 0.317). These results suggest that the leg phase angle can be an indicator of voluntary and evoked muscle contractile properties but not the neuromuscular activity of the plantar flexors, irrespective of sex and age.
Thigh muscle thickness on ultrasonography for diagnosing sarcopenia: The <scp>Kyoto‐Kameoka</scp> study

Tsukasa Yoshida, Yuya Watanabe, Keiichi Yokoyama, Misaka Kimura, Yosuke Yamada

Geriatrics & Gerontology International　2023/10/27
Publisher: Wiley
DOI： 10.1111/ggi.14714 　

ISSN： 1444-1586

eISSN： 1447-0594

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Aim The Asian Working Group for Sarcopenia 2019 consensus reported that evidence for the diagnosis of sarcopenia based on ultrasonography findings is lacking. The revised European Working Group on Sarcopenia in Older People consensus stated that ultrasonography is reliable and valid for assessing muscle size in older adults. The present study aimed to determine the predictive accuracy of ultrasonography for sarcopenia in older adults in Japan. Methods A total of 1229 participants aged 65–91 years were included in this cross‐sectional study. The thickness of the anterior compartment of the right thigh was assessed using B‐mode ultrasonography. The measurement position was at the midpoint of the thigh. In addition, the grip strength, gait speed, Five‐Time Sit‐to‐Stand Test, Short Physical Performance Battery score and skeletal muscle mass index were evaluated. Sarcopenia was diagnosed based on the Asian Working Group for Sarcopenia 2019 algorithm. We calculated the area under the receiver operating characteristic curve. Results The area under the receiver operating characteristic curves (95% confidence intervals) and cutoff values for the thigh muscle thickness in sarcopenia were 0.901 (0.856–0.946) and 4.0 cm in men, respectively, and 0.923 (0.851–0.995) and 3.1 cm in women, respectively. The area under the receiver operating characteristic curve for each subdomain of sarcopenia, such as grip strength and gait speed, ranged from 0.618 to 0.872. Conclusions In the present study, the suggested cutoff mid‐thigh muscle thicknesses on ultrasonography for predicting sarcopenia were 4.0 cm in men and 3.1 cm in women. Geriatr Gerontol Int 2023; ••: ••–••.
Effect of overweight/obesity and metabolic syndrome on frailty in middle‐aged and older Japanese adults Peer-reviewed

Yuki Nishida, Yosuke Yamada, Satoshi Sasaki, Eiichiro Kanda, Yoshihiko Kanno, Tatsuhiko Anzai, Kunihiko Takahashi, Keita Yamauchi, Fuminori Katsukawa

Obesity Science & Practice　10　(1)　2023/09/27
Publisher: Wiley
DOI： 10.1002/osp4.714 　

ISSN： 2055-2238

eISSN： 2055-2238

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Abstract Background The potential for developing frailty exists in middle‐aged and older adults. While obesity and metabolic syndrome (MetS) increase the risk of frailty in older adults, this relationship remains unclear in middle‐aged adults, who are prone to developing lifestyle‐related diseases. Objective To examine the effect of overweight/obesity and MetS on frailty development in middle‐aged and older Japanese adults using real‐world data. Methods This nationwide cohort study used exhaustive health insurance claims data of 3,958,708 Japanese people from 2015 to 2019 provided by the Japan Health Insurance Association. Participants aged ≥35 and < 70 years who received health checkups in 2015 were included. Multivariate logistic regression was used to assess the effect of body mass index (BMI) and MetS or MetS components (i.e., diabetes, hypertension, and dyslipidemia) in 2015 on frailty risk assessed using the hospital frailty risk score in 2019. Additionally, a subgroup analysis was performed to examine the interaction effects of MetS components and 4‐year weight change (%) on frailty risk among participants who were overweight and obese (BMI ≥25 kg/m²). Results In 2019, 7204 (0.2%) and 253,671 (6.4%) participants were at high and intermediate frailty risks, respectively. Obesity and MetS were independently associated with intermediate/high frailty risk (odds ratio (OR) 1.36, p < 0.05; OR 1.23, p < 0.05, respectively) and high frailty risk (OR 1.80, p < 0.05; OR 1.37, p < 0.05, respectively) in all participants. Although all MetS components were frailty risk factors, these effects diminished with age in both sexes. Subgroup analysis of patients with diabetes revealed that 5%–10% weight loss was associated with reduced frailty risk in both sexes. Conclusions Obesity, MetS, and MetS components were independent frailty risk factors in middle‐aged and older Japanese adults. Weight loss of up to 10% over 4 years prevented frailty in patients with diabetes who were overweight and obese.
Greater male variability in daily energy expenditure develops through puberty

Lewis G. Halsey, Vincent Careau, Philip N. Ainslie, Heliodoro Alemán-Mateo, Lene F. Andersen, Liam J. Anderson, Leonore Arab, Issad Baddou, Linda Bandini, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V. C. Bouten, Pascal Bovet, Soren Brage, Maciej S. Buchowski, Nancy Butte, Stephan G. Camps, Regian Casper, Graeme L. Close, Lisa H. Colbert, Jamie A. Cooper, Richard Cooper, Prasangi Dabare, Sai Krupa Das, Peter S. W. Davies, Sanjoy Deb, Christine Delisle Nyström, William Dietz, Lara R. Dugas, Simon Eaton, Ulf Ekelund, Asmaa El Hamdouchi, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Melanie Gillingham, Annelies H. Goris, Michael Gurven, Hinke Haisma, Catherine Hambly, Daniel Hoffman, Marije B. Hoos, Sumei Hu, Noorjehan Joonas, Annemiek Joosen, Peter Katzmarzyk, Kitty P. Kempen, Misaka Kimura, William E. Kraus, Wantanee Kriengsinyos, Rebecca Kuriyan, Robert F. Kushner, Estelle V. Lambert, Pulani Lanerolle, Christel L. Larsson, Nader Lessan, Marie Löf, Corby Martin, Eric Matsiko, Gerwin A. Meijer, James C. Morehen, James P. Morton, Aviva Must, Marian Neuheuser, Theresa A. Nicklas, Robert M. Ojiambo, Kirsi H. Pietilainen, Yannis P. Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L. Prentice, Roberto Rabinovich, Susan B. Racette, David A. Raichen, Eric Ravussin, Leanne Redman, John J. Reilly, Rebecca Reynolds, Susan Roberts, Jennifer C. Rood, Dulani Samaranayake, Luís B. Sardinha, Albertine J. Scuitt, Analiza M. Silva, Srishti Sinha, Anders M. Sjödin, Eric Stice, Albert Stunkard, Samuel S. Urlacher, Mauro Eduardo Valencia, Giulio Valenti, Ludo M. van Etten, Edgar A. Van Mil, Jeanine A. Verbunt, Jonathan C. K. Wells, George Wilson, Brian Wood, Tsukasa Yoshida, Xueying Zhang, Alexia Murphy-Alford, Cornelia Loechl, Amy Luke, Herman Pontzer, Jennifer Rood, Hiroyuki Sagayama, Klaas R. Westerterp, William W. Wong, Yosuke Yamada, John R. Speakman

Biology Letters　19　(9)　2023/09/20
Publisher: The Royal Society
DOI： 10.1098/rsbl.2023.0152 　

eISSN： 1744-957X

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There is considerably greater variation in metabolic rates between men than between women, in terms of basal, activity and total (daily) energy expenditure (EE). One possible explanation is that EE is associated with male sexual characteristics (which are known to vary more than other traits) such as musculature and athletic capacity. Such traits might be predicted to be most prominent during periods of adolescence and young adulthood, when sexual behaviour develops and peaks. We tested this hypothesis on a large dataset by comparing the amount of male variation and female variation in total EE, activity EE and basal EE, at different life stages, along with several morphological traits: height, fat free mass and fat mass. Total EE, and to some degree also activity EE, exhibit considerable greater male variation (GMV) in young adults, and then a decreasing GMV in progressively older individuals. Arguably, basal EE, and also morphometrics, do not exhibit this pattern. These findings suggest that single male sexual characteristics may not exhibit peak GMV in young adulthood, however total and perhaps also activity EE, associated with many morphological and physiological traits combined, do exhibit GMV most prominently during the reproductive life stages.
Association between the appendicular extracellular-to-intracellular water ratio and all-cause mortality: A 10-year longitudinal study. International-journal

Chiharu Iwasaka, Yosuke Yamada, Yuichiro Nishida, Megumi Hara, Jun Yasukata, Nobuyuki Miyoshi, Chisato Shimanoe, Hinako Nanri, Takuma Furukawa, Kayoko Koga, Horita Mikako, Yasuki Higaki, Keitaro Tanaka

The journals of gerontology. Series A, Biological sciences and medical sciences　2023/09/19

DOI： 10.1093/gerona/glad211 　

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The appendicular extracellular-to-intracellular water ratio (A-E/I) is a potential marker of skeletal muscle quality, reflecting the balance of water distribution between the extracellular and intracellular compartments of the appendicular limb regions. A-E/I has been increasingly used in recent studies; however, its association with adverse outcomes remains unclear. This study investigated the potential association between A-E/I and all-cause mortality. A prospective cohort study of 8015 middle-aged and older adults (comprised of 4755 women, aged 45-74 years) residing in a Japanese community was conducted. The baseline assessment was performed between 2010 and 2012, and the follow-up period lasted until July 2022. A-E/I and skeletal muscle mass were measured using segmental bioelectrical impedance spectroscopy. Handgrip strength (HGS) was measured using a Smedley-type dynamometer. Lifestyle, medical history, and physical activity (PA) were assessed by questionnaire and accelerometer. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) for each quartile (Q) of A-E/I were estimated using the multivariable cox regression model. During a 10.5-year median follow-up, mortality rates were 8.9 and 3.6 per 1000 person-years for men (292 deaths) and women (174 deaths), respectively. A-E/I quartiles were positively associated with all-cause mortality in both sexes (men: Q1, HR: 1.0 [95% CI: reference], Q4, HR: 1.8 [1.1-2.9], P trend <0.05; women, Q4, HR: 2.2 [1.3-3.8], P trend <0.01). This association remained significant after further adjustment for skeletal muscle mass and HGS (P trend < 0.05). Our findings suggest that A-E/I serves as an early predictive marker for mortality in middle-aged and older Japanese adults.
Association of Regional Muscle Thickness and Echo Intensity with Muscle Volume, Intramuscular Adipose Tissue, and Strength of the Quadriceps Femoris

Yoshihiro Fukumoto, Masashi Taniguchi, Tetsuya Hirono, Masahide Yagi, Momoko Yamagata, Ryusuke Nakai, Yosuke Yamada, Misaka Kimura, Noriaki Ichihashi

Clinical Interventions in Aging　Volume 18　1513-1521　2023/09
Publisher: Informa UK Limited
DOI： 10.2147/cia.s424504 　

eISSN： 1178-1998
The bioelectrical impedance analysis (BIA) international database: aims, scope, and call for data. International-journal

Analiza M Silva, Francesco Campa, Silvia Stagi, Luís A Gobbo, Roberto Buffa, Stefania Toselli, Diego Augusto Santos Silva, Ezequiel M Gonçalves, Raquel D Langer, Gil Guerra-Júnior, Dalmo R L Machado, Emi Kondo, Hiroyuki Sagayama, Naomi Omi, Yosuke Yamada, Tsukasa Yoshida, Wataru Fukuda, Maria Cristina Gonzalez, Silvana P Orlandi, Josely C Koury, Tatiana Moro, Antonio Paoli, Salome Kruger, Aletta E Schutte, Angela Andreolli, Carrie P Earthman, Vanessa Fuchs-Tarlovsky, Alfredo Irurtia, Jorge Castizo-Olier, Gabriele Mascherini, Cristian Petri, Laura K Busert, Mario Cortina-Borja, Jeanette Bailey, Zachary Tausanovitch, Natasha Lelijveld, Hadeel Ali Ghazzawi, Adam Tawfiq Amawi, Grant Tinsley, Suvi T Kangas, Cécile Salpéteur, Adriana Vázquez-Vázquez, Mary Fewtrell, Chiara Ceolin, Giuseppe Sergi, Leigh C Ward, Berit L Heitmann, Roberto Fernandes da Costa, German Vicente-Rodriguez, Margherita Micheletti Cremasco, Alessia Moroni, John Shepherd, Jordan Moon, Tzachi Knaan, Manfred J Müller, Wiebke Braun, José M García-Almeida, António L Palmeira, Inês Santos, Sofus C Larsen, Xueying Zhang, John R Speakman, Lindsay D Plank, Boyd A Swinburn, Jude Thaddeus Ssensamba, Keisuke Shiose, Edilson S Cyrino, Anja Bosy-Westphal, Steven B Heymsfield, Henry Lukaski, Luís B Sardinha, Jonathan C Wells, Elisabetta Marini

European journal of clinical nutrition　2023/08/02

DOI： 10.1038/s41430-023-01310-x 　

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BACKGROUND: Bioelectrical impedance analysis (BIA) is a technique widely used for estimating body composition and health-related parameters. The technology is relatively simple, quick, and non-invasive, and is currently used globally in diverse settings, including private clinicians' offices, sports and health clubs, and hospitals, and across a spectrum of age, body weight, and disease states. BIA parameters can be used to estimate body composition (fat, fat-free mass, total-body water and its compartments). Moreover, raw measurements including resistance, reactance, phase angle, and impedance vector length can also be used to track health-related markers, including hydration and malnutrition, and disease-prognostic, athletic and general health status. Body composition shows profound variability in association with age, sex, race and ethnicity, geographic ancestry, lifestyle, and health status. To advance understanding of this variability, we propose to develop a large and diverse multi-country dataset of BIA raw measures and derived body components. The aim of this paper is to describe the 'BIA International Database' project and encourage researchers to join the consortium. METHODS: The Exercise and Health Laboratory of the Faculty of Human Kinetics, University of Lisbon has agreed to host the database using an online portal. At present, the database contains 277,922 measures from individuals ranging from 11 months to 102 years, along with additional data on these participants. CONCLUSION: The BIA International Database represents a key resource for research on body composition.
Relationship between Finger-circle Test and Frailty in Community-dwelling Middle-aged and Older Adults by Body Mass Index Category: A Cross-sectional Study Peer-reviewed

Atsuko TANIDE, Tsukasa YOSHIDA, Daiki WATANABE, Takashi NAKAGATA, Yosuke YAMADA, Naomi SAWADA, Megumi OKABAYASHI, Hidekazu SHIMADA, Nobuo NISHI, Motohiko MIYACHI

50　(4)　129-140　2023/08

DOI： 10.15063/rigaku.12373 　
Comparison of bioelectrical impedance indices for skeletal muscle mass and intracellular water measurements of physically active young men and athletes. International-journal

Hiroyuki Sagayama, Emi Kondo, Yoko Tanabe, Akiko Uchizawa, William J Evans, Mahalakshmi Shankaran, Edna Nyangau, Marc Hellerstein, Keisuke Shiose, Tsukasa Yoshida, Jun Yasukata, Yasuki Higaki, Takahiro Ohnishi, Hideyuki Takahashi, Yosuke Yamada

The Journal of nutrition　2023/07/24

DOI： 10.1016/j.tjnut.2023.07.010 　

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BACKGROUND: Bioelectrical impedance analysis (BIA) is a minimally invasive, safe, easy, and quick technology used to determine body composition. OBJECTIVE: We compared the relationship among impedance indices obtained using single-frequency BIA, multi-frequency BIA, bioelectrical impedance spectroscopy (BIS), and skeletal muscle mass (SMM) of physically active young men and athletes using the creatine (methyl-d3) dilution method. We also compared the SMM and intracellular water (ICW) of athletes and active young men measured using a reference stable isotope dilution and BIS method, respectively. METHODS: We analyzed data of 28 men (mean age, 20 ± 2 years) who exercised regularly. Single-frequency BIA at 5 kHz and 50 kHz (R5 and R50), multi-frequency BIA (R250-5), and BIS (RICW) methods of determining the SMM were compared. The deuterium and bromide dilution methods of obtaining the total body water, ICW, and extracellular water measurements were also used, and the results were compared to those acquired using bioimpedance methods. RESULTS: The correlation coefficients between SMM and L2/R5, L2/R50, L2/R250-5, and L2/RICW were 0.738, 0.762, 0.790, and 0.790, respectively (p < 0.01). The correlation coefficients between ICW and L2/R5, L2/R50, L2/R250-5, and L2/RICW were 0.660, 0.687, 0.758, and 0.730, respectively (p < 0.001). However, the correlation coefficients of L2/R50, L2/R250-5, and L2/RICW for SMM and ICW were not significantly different. CONCLUSIONS: Our findings suggest that single-frequency BIA at L2/R50, multi-frequency BIA, and BIS are valid for assessing the SMM of athletes and active young men. Additionally, we confirmed that the SMM and ICW were correlated with single-frequency BIA, multi-frequency BIA, and BIS. Bioimpedance technologies may be dependable and practical means for assessing SMM and hydration compartment status of active young adult males, however, cross-validation is needed.
Sitting vs. supine ultrasound measurements of the vastus medialis: correlations with MRI measurements and age considerations. International-journal

Masashi Taniguchi, Yoshihiro Fukumoto, Masahide Yagi, Tetsuya Hirono, Momoko Yamagata, Ryusuke Nakai, Yosuke Yamada, Misaka Kimura, Noriaki Ichihashi

Journal of physiological anthropology　42　(1)　14-14　2023/07/15

DOI： 10.1186/s40101-023-00331-6 　

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BACKGROUND: Muscle thickness (MT) and echo intensity (EI) measurements are ultrasound alternatives to magnetic resonance imaging (MRI) for evaluating muscle quantity and quality. The vastus medialis (VM) is a clinically important muscle, and assessment methods that most accurately reflect its quantity and quality are required. This study aimed to examine the correlation between MT and EI measured in the supine and sitting postures with corresponding MRI-measured muscle quantity and quality indices. METHODS: In total, 134 adults (91 older and 43 young) participated in this study. Ultrasound images of the VM were acquired in the supine and sitting postures, and MT and EI were measured. The cross-sectional area (CSA), muscle volume (MV), and intramuscular adipose tissue (intraMAT) of the VM were evaluated from MRI images using T1-weighted and Dixon methods. Pearson's coefficients were used to quantify the correlation strength amongst pairs of dependent variables. Meng's test was used to test for correlation coefficient differences between the two measurement postures (supine and sitting). RESULTS: The correlation coefficients amongst MT, CSA, and MV were significantly higher in the sitting posture than in the supine posture. EI measured in the supine and sitting postures correlated significantly with intraMAT, and in young individuals, these correlation coefficients were significantly higher in the sitting posture than in the supine posture. CONCLUSIONS: These findings suggest that assessment of VM muscle quantity in the sitting posture is superior for young and older individuals, and assessment of VM muscle quality in the sitting posture is most effective in younger individuals.
Body cell mass to fat-free mass ratio and extra-to-intracellular water ratio are related to maximal oxygen uptake. International-journal

Yosuke Yamada, Tsukasa Yoshida, Haruka Murakami, Yuko Gando, Ryoko Kawakami, Harumi Ohno, Kumpei Taniswa, Kana Konishi, Julien Tripette, Emi Kondo, Takashi Nakagata, Hinako Nanri, Motohiko Miyachi

The journals of gerontology. Series A, Biological sciences and medical sciences　2023/06/01

DOI： 10.1093/gerona/glad140 　

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Fat-free mass (FFM) is a heterogeneous compartment comprising body cell mass (BCM), intracellular water (ICW), extracellular solids, and extracellular water (ECW). The BCM/FFM and ECW/ICW ratios vary among individuals and decrease with age. This study aimed to determine whether BCM/FFM and ECW/ICW ratios are predictors of maximal oxygen uptake (V̇O2peak) independently of age, sex, and objectively measured physical activity (PA). A total of 115 Japanese males and females, aged 55.3 ± 8.0 years (mean ± standard deviation), were included in the study. Anthropometry, explosive leg muscle power, and V̇O2peak were measured, and BCM, FFM, ICW, and ECW were estimated. Step count and PA were objectively measured using a triaxial accelerometer. Blood flow volume was assessed using ultrasonography. BCM and ICW were negatively correlated with age, whereas FFM and ECW were not significantly correlated with age. FFM, ICW/ECW, BCM/FFM, step counts, moderate and vigorous PA, and leg muscle power were positively correlated with V̇O2peak, even after adjusting for age and sex (P<0.05). Multiple regression analysis indicated that either BCM/FFM or ECW/ICW, leg power, and objectively measured PA were associated with V̇O2peak independent of age, sex, and FFM. Blood flow volume was significantly correlated with ECW (P<0.05), but not with BCM. The BCM/FFM and ECW/ICW ratios were significant predictors of VO2peak, independent of age, sex, FFM, leg power, and objectively measured PA.
Total daily energy expenditure has declined over the past three decades due to declining basal expenditure, not reduced activity expenditure

John R. Speakman, Jasper M. A. de Jong, Srishti Sinha, Klaas R. Westerterp, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Liam J. Anderson, Lenore Arab, Kweku Bedu-Addo, Stephane Blanc, Alberto G. Bonomi, Pascal Bovet, Soren Brage, Maciej S. Buchowski, Nancy F. Butte, Stefan G.J.A. Camps, Jamie A. Cooper, Richard Cooper, Sai Krupa Das, Peter S. W. Davies, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Melanie Gillingham, Santu Ghosh, Annelies H. Goris, Michael Gurven, Lewis G. Halsey, Catherine Hambly, Hinke H. Haisma, Daniel Hoffman, Sumei Hu, Annemiek M. Joosen, Jennifer L. Kaplan, Peter Katzmarzyk, William E. Kraus, Robert F. Kushner, William R. Leonard, Marie Löf, Corby K. Martin, Eric Matsiko, Anine C. Medin, Erwin P. Meijer, Marian L. Neuhouser, Theresa A. Nicklas, Robert M. Ojiambo, Kirsi H. Pietiläinen, Jacob Plange-Rhule, Guy Plasqui, Ross L. Prentice, Susan B. Racette, David A. Raichlen, Eric Ravussin, Leanne M. Redman, Susan B. Roberts, Michael C. Rudolph, Luis B. Sardinha, Albertine J. Schuit, Analiza M. Silva, Eric Stice, Samuel S. Urlacher, Giulio Valenti, Ludo M. Van Etten, Edgar A. Van Mil, Brian M. Wood, Jack A. Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J. Murphy-Alford, Cornelia U. Loechl, Anura Kurpad, Amy H. Luke, Herman Pontzer, Matthew S. Rodeheffer, Jennifer Rood, Dale A. Schoeller, William W. Wong

Nature Metabolism　5　(4)　579-588　2023/04/26
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s42255-023-00782-2 　

eISSN： 2522-5812
Association between excess mortality in depressive status and frailty among older adults: A population-based Kyoto-Kameoka prospective cohort study. International-journal

Daiki Watanabe, Tsukasa Yoshida, Yosuke Yamada, Yuya Watanabe, Emi Yamagata, Motohiko Miyachi, Yoshinori Fujiwara, Misaka Kimura

Archives of gerontology and geriatrics　110　104990-104990　2023/03/06

DOI： 10.1016/j.archger.2023.104990 　

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OBJECTIVES: Frailty has been shown to be a mediator of the risk of excess death due to depression in older adults, although this relationship has not been sufficiently investigated. Our objective was to evaluate this relationship. METHODS: We used data from 7,913 Japanese people aged≥65 years who participated in the Kyoto-Kameoka prospective cohort study and who provided valid responses to the Geriatric Depression Scale-15 (GDS-15) and the World Health Organization-Five Well-Being Index (WHO-5) in mail-in surveys. Depressive status was assessed using the GDS-15 and WHO-5. Frailty was evaluated using the Kihon Checklist. Data on mortality were collected from February 15, 2012, to November 30, 2016. We evaluated the relationship between depression and all-cause mortality risk using a Cox proportional-hazards model. RESULTS: The prevalence of depressive status assessed by GDS-15 and WHO-5 was 25.4% and 40.1%, respectively. In total, 665 deaths were recorded during a median follow-up period of 4.75 years (35,878 person-years). After adjusting for confounders, we found that depressive status assessed by the GDS-15 had a higher risk of mortality than those without it (hazard ratio [HR] 1.62, 95% confidence interval [CI] 1.38-1.91). This association was moderately weaker when adjusted for frailty (HR 1.46, 95% CI 1.23-1.73). Similar results were observed when depression was assessed with the WHO-5. CONCLUSION: Our findings suggest that the risk of excess death due to depressive status in older adults may be partially explained by frailty. This indicates a need to focus on improving frailty besides conventional depression treatments.
Association between Intra- and Extra-Cellular Water Ratio Imbalance and Natriuretic Peptides in Patients Undergoing Hemodialysis. International-journal

Yui Nakayama, Yosuke Yamada, Shingo Ishii, Mai Hitaka, Keisuke Yamazaki, Motoyuki Masai, Nobuhiko Joki, Ken Sakai, Yasushi Ohashi

Nutrients　15　(5)　2023/03/03

DOI： 10.3390/nu15051274 　

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Natriuretic peptides are associated with malnutrition and volume overload. Over-hydration cannot simply be explained by excess extracellular water in patients undergoing hemodialysis. We assessed the relationship between the extracellular and intracellular water (ECW/ICW) ratio, N-terminal pro-B-type natriuretic peptide (NT-proBNP), human atrial natriuretic peptide (hANP), and echocardiographic findings. Body composition was examined by segmental multi-frequency bioelectrical impedance analysis in 368 patients undergoing maintenance dialysis (261 men and 107 women; mean age, 65 ± 12 years). Patients with higher ECW/ICW ratio quartiles tended to be older, were on dialysis longer, and had higher post-dialysis blood pressure and lower body mass index, ultrafiltration volume, serum albumin, blood urea nitrogen, and creatinine levels (p < 0.05). The ECW/ICW ratio significantly increased with decreasing ICW, but not with ECW. Patients with a higher ECW/ICW ratio and lower percent fat had significantly higher natriuretic peptide levels. After adjusting for covariates, the ECW/ICW ratio remained an independent associated factor for natriuretic peptides (β = 0.34, p < 0.001 for NT-proBNP and β = 0.40, p < 0.001 for hANP) and the left ventricular mass index (β = 0.20, p = 0.002). The ICW-ECW volume imbalance regulated by decreased cell mass may explain the reserve capacity for fluid accumulation in patients undergoing hemodialysis.
Dose-response relationship between daily step count and prevalence of sarcopenia: A cross-sectional study. International-journal

Chiharu Iwasaka, Yosuke Yamada, Yuichiro Nishida, Megumi Hara, Jun Yasukata, Nobuyuki Miyoshi, Chisato Shimanoe, Hinako Nanri, Takuma Furukawa, Kayoko Koga, Mikako Horita, Yasuki Higaki, Keitaro Tanaka

Experimental gerontology　175　112135-112135　2023/03/01

DOI： 10.1016/j.exger.2023.112135 　

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OBJECTIVES: Daily step counts are an easy-to-understand indicator of physical activity; however, there is limited evidence regarding the optimal daily step count to prevent sarcopenia. This study examined the dose-response relationship between daily step count and the prevalence of sarcopenia and explored the optimal dose. DESIGN: Cross-sectional study. SETTING AND PARTICIPANTS: The study included 7949 community-dwelling middle-aged and older adults (aged 45-74 years) from Japan. MEASUREMENTS: Skeletal muscle mass (SMM) was assessed using bioelectrical impedance spectroscopy, and muscle strength was quantified through handgrip strength (HGS) measurement. Participants who exhibited both low HGS (men: <28 kg, women: <18 kg) and low SMM (lowest quartile in each sex-specific category) were defined as having sarcopenia. Daily step counts were measured for 10 days using a waist-mounted accelerometer. To examine the association between daily step count and sarcopenia, a multivariate logistic regression analysis was performed, adjusting for potential confounding factors such as age, sex, body mass index, smoking status, alcohol consumption, protein intake, and medical history. The odds ratios (ORs) and confidence intervals (CIs) were calculated based on the daily step counts categorized into quartiles (Q1-Q4). Finally, a restricted cubic spline curve was fitted to further investigate the dose-response relationship between daily step count and sarcopenia. RESULTS: The prevalence of sarcopenia in the overall participants was 3.3 % (259/7949 participants), with a mean daily step count of 7292 ± 2966 steps. Expressed in quartiles, the mean daily step counts were 3873 ± 935 steps in Q1, 6025 ± 503 steps in Q2, 7942 ± 624 steps in Q3, and 11,328 ± 1912 steps in Q4. The prevalence of sarcopenia in each quartile of daily step count was 4.7 % (93/1987 participants) in Q1, 3.4 % (68/1987 participants) in Q2, 2.7 % (53/1988 participants) in Q3, and 2.3 % (45/1987 participants) in Q4. The ORs and 95 % CIs adjusted for covariates demonstrated a statistically significant inverse association between daily step count and sarcopenia prevalence (P for trend <0.01), as follows: Q1, reference; Q2, 0.79 (95 % CI: 0.55-1.11); Q3, 0.71 (95 % CI: 0.49-1.03); Q4, 0.61 (95 % CI: 0.41-0.90). The restricted cubic spline curve indicated that the ORs leveled off at approximately 8000 steps per day, and no statistically significant decrease in ORs was observed for daily step counts above this threshold. CONCLUSIONS: The study found a significant inverse association between daily step count and the prevalence of sarcopenia, with the association plateauing when the daily step count exceeded approximately 8000 steps. These findings suggest that 8000 steps per day may be the optimal dose to prevent sarcopenia. Further intervention and longitudinal studies are needed to validate the results.
Dose-Response Relationships between Objectively Measured Daily Steps and Mortality among Frail and Non-frail Older Adults. International-journal

Daiki Watanabe, Tsukasa Yoshida, Yuya Watanabe, Yosuke Yamada, Motohiko Miyachi, Misaka Kimura

Medicine and science in sports and exercise　2023/02/02

DOI： 10.1249/MSS.0000000000003133 　

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PURPOSE: Whether the association between objectively assessed physical activity and mortality differs between adults with versus those without frailty is unclear. We investigated this association in community-dwelling older adults. METHODS: This prospective study used the data of 4165 older adults aged 65 years or older from the Kyoto-Kameoka study in Japan who wore a triaxial accelerometer (EW-NK52). The number of steps was classified by quartiles using the average daily value of data obtained from the accelerometer across four or more days. Frailty was evaluated using the validated Kihon Checklist. We evaluated the association between mortality and daily steps using a multivariable Cox proportional hazards analysis and restricted spline model. RESULTS: The average daily steps for the first, second, third, and fourth quartiles were 1786, 3030, 4452, and 7502, respectively. In total, 113 deaths were recorded during a median follow-up of 3.38 years (14061 person-years). After adjusting for confounders, the top quartile was associated with a lower hazard ratio (HR) for mortality than the bottom quartile (HR: 0.39, 95% confidence interval: 0.18-0.85). In a stratified model by frailty status, the daily step count dose-response curve at which the HR for mortality plateaued among non-frail individuals was approximately 5000-7000 steps per day. In contrast, the daily step count showed an inverse relationship with mortality at approximately 5000 steps or more per day in frail individuals. CONCLUSIONS: The relationship between daily steps and mortality is different between those with and those without frailty, and people with frailty may require more daily steps than those with non-frailty to achieve the inverse relationship with mortality. These findings may be useful for informing future physical activity guidelines.
Association of appendicular extracellular-to-intracellular water ratio with age, muscle strength, and physical activity in 8,018 community-dwelling middle-aged and older adults. International-journal

Chiharu Iwasaka, Yosuke Yamada, Yuichiro Nishida, Megumi Hara, Jun Yasukata, Nobuyuki Miyoshi, Chisato Shimanoe, Hinako Nanri, Takuma Furukawa, Kayoko Koga, Mikako Horita, Yasuki Higaki, Keitaro Tanaka

Archives of gerontology and geriatrics　108　104931-104931　2023/01/18

DOI： 10.1016/j.archger.2023.104931 　

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BACKGROUND: The appendicular extracellular-to-intracellular water ratio (Ap ECW/ICW) has recently gained attention as a non-invasive measurable marker of muscle quality. However, there is a lack of basic evidence regarding age-related changes, sex differences, contribution to muscle strength independent of skeletal muscle mass (SMM), and potential improvement through physical activity (PA) in Ap ECW/ICW. METHODS: This cross-sectional study enrolled 8,018 middle-aged and older Japanese individuals (aged 45-75 years). The Ap ECW/ICW and SMM were measured using segmental bioelectrical impedance spectroscopy. Muscle strength was evaluated by measuring the handgrip strength (HGS) with a dynamometer, and the PA level (PAL) was measured with an accelerometer. We performed a linear regression analysis of the associations of the Ap ECW/ICW with age, HGS, and PAL. RESULTS: The Ap ECW/ICW increased by 0.019 for men and 0.014 for women per 5-year increase in age (p < 0.001), and the age-related increase was greater in men than in women (p for interaction <0.001). The Ap ECW/ICW was more strongly associated with the HGS than with the SMM in both men and women (p < 0.001). PAL showed a significant inverse association with the Ap ECW/ICW in both men and women (p < 0.001). CONCLUSIONS: Ap ECW/ICW is higher with age, and it varies by sex. The Ap ECW/ICW may reflect muscle strength more than the SMM, suggesting that the Ap ECW/ICW may be improved by PA. The findings from this study may provide a framework for further Ap ECW/ICW research.
Differential association of total and regional muscle mass and quality with physical performance in community-dwelling older adults

Hiroki Monjo, Yoshihiro Fukumoto, Masashi Taniguchi, Yosuke Yamada, Misaka Kimura

Journal of Medical Ultrasonics　50　(2)　221-228　2023/01/10
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s10396-022-01275-7 　

ISSN： 1346-4523

eISSN： 1613-2254

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PURPOSE: In this study, we examined the association among total muscle mass, regional muscle mass, muscle quality, and various types of physical performance in community-dwelling older adults. METHODS: This study included 195 community-dwelling older adults (61 males and 134 females). The muscle thickness and echo intensity of the quadriceps femoris and triceps surae were measured using ultrasound, and the skeletal muscle mass index was evaluated using bioelectrical impedance analysis. Physical performance was measured using the 30-s standing test (CS30), Timed up-and-go test (TUG), 10-m maximum walking speed (10MWT), vertical jump test (VJT), and grip strength. RESULTS: Partial correlation analysis after controlling for age, sex, and body mass index showed that CS30 was significantly correlated with muscle thickness and echo intensity of the quadriceps femoris. The TUG and VJT were significantly correlated with muscle thickness of the triceps surae, and grip strength was significantly correlated with muscle thickness of the triceps surae and skeletal muscle mass index. Stepwise multiple regression analyses indicated that the echo intensity of the quadriceps femoris was a significant predictor of CS30, and the muscle thickness of the triceps surae was a significant predictor of TUG, VJT, and grip strength, whereas the skeletal muscle mass index was not a significant predictor of any physical performance test. CONCLUSION: Our results suggest that regional muscle mass and quality are more important than skeletal muscle mass index for predicting physical performance.
超音波測定肢位が内側広筋の筋厚・筋輝度とMRI筋体積・筋断面積および筋内脂肪割合との関係に及ぼす影響

谷口匡史, 福元喜啓, 八木優英, 廣野哲也, 山縣桃子, 中井隆介, 山田陽介, 木村みさか, 市橋則明

基礎理学療法学　25　(Suppl.1)　9-9　2023/01
Publisher: (一社)日本基礎理学療法学会
eISSN： 2436-6382
大腿四頭筋における筋厚・筋輝度とMRI筋体積および筋内脂肪割合との関連長軸上の撮像部位の違いによる検討

福元喜啓, 谷口匡史, 八木優英, 廣野哲也, 山縣桃子, 中井隆介, 山田陽介, 木村みさか, 市橋則明

基礎理学療法学　25　(Suppl.1)　43-43　2023/01
Publisher: (一社)日本基礎理学療法学会
eISSN： 2436-6382
Muscle Glycogen Assessment and Relationship with Body Hydration Status: A Narrative Review

Keisuke Shiose, Hideyuki Takahashi, Yosuke Yamada

Nutrients　15　(1)　155-155　2022/12/29
Publisher: MDPI AG
DOI： 10.3390/nu15010155 　

eISSN： 2072-6643

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Muscle glycogen is a crucial energy source for exercise, and assessment of muscle glycogen storage contributes to the adequate manipulation of muscle glycogen levels in athletes before and after training and competition. Muscle biopsy is the traditional and gold standard method for measuring muscle glycogen; alternatively, 13C magnetic resonance spectroscopy (MRS) has been developed as a reliable and non-invasive method. Furthermore, outcomes of ultrasound and bioimpedance methods have been reported to change in association with muscle glycogen conditions. The physiological mechanisms underlying this activity are assumed to involve a change in water content bound to glycogen; however, the relationship between body water and stored muscle glycogen is inconclusive. In this review, we discuss currently available muscle glycogen assessment methods, focusing on 13C MRS. In addition, we consider the involvement of muscle glycogen in changes in body water content and discuss the feasibility of ultrasound and bioimpedance outcomes as indicators of muscle glycogen levels. In relation to changes in body water content associated with muscle glycogen, this review broadens the discussion on changes in body weight and body components other than body water, including fat, during carbohydrate loading. From these discussions, we highlight practical issues regarding muscle glycogen assessment and manipulation in the sports field.
質問紙で調査した地域在住自立高齢者の身体活動京都-亀岡スタディ

山田陽介, 吉田司, 渡邊裕也, 渡邉大輝, 山縣恵美, 南里妃名子, 伊達平和, 糸井亜弥, 藤田裕之, 宮地元彦, 木村みさか

運動疫学研究: Research in Exercise Epidemiology　24　(2)　100-101　2022/12
Publisher: 日本運動疫学会
ISSN： 1347-5827

eISSN： 2434-2017
質問紙で調査した要介護・要支援認定高齢者の身体活動京都-亀岡スタディ

山田陽介, 吉田司, 渡邊裕也, 渡邉大輝, 山縣恵美, 南里妃名子, 伊達平和, 糸井亜弥, 藤田裕之, 宮地元彦, 木村みさか

運動疫学研究: Research in Exercise Epidemiology　24　(2)　114-115　2022/12
Publisher: 日本運動疫学会
ISSN： 1347-5827

eISSN： 2434-2017
質問紙で調査した地域在住自立高齢者の身体活動京都-亀岡スタディ

山田陽介, 吉田司, 渡邊裕也, 渡邉大輝, 山縣恵美, 南里妃名子, 伊達平和, 糸井亜弥, 藤田裕之, 宮地元彦, 木村みさか

運動疫学研究: Research in Exercise Epidemiology　24　(2)　100-101　2022/12
Publisher: 日本運動疫学会
ISSN： 1347-5827

eISSN： 2434-2017
質問紙で調査した要介護・要支援認定高齢者の身体活動京都-亀岡スタディ

山田陽介, 吉田司, 渡邊裕也, 渡邉大輝, 山縣恵美, 南里妃名子, 伊達平和, 糸井亜弥, 藤田裕之, 宮地元彦, 木村みさか

運動疫学研究: Research in Exercise Epidemiology　24　(2)　114-115　2022/12
Publisher: 日本運動疫学会
ISSN： 1347-5827

eISSN： 2434-2017
Validation of the Kihon Checklist and the frailty screening index for frailty defined by the phenotype model in older Japanese adults

Daiki Watanabe, Tsukasa Yoshida, Yuya Watanabe, Yosuke Yamada, Motohiko Miyachi, Misaka Kimura

BMC Geriatrics　22　(1)　2022/12
Publisher: Springer Science and Business Media LLC
DOI： 10.1186/s12877-022-03177-2 　

eISSN： 1471-2318

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Abstract Background The term “frailty” might appear simple, but the methods used to assess it differ among studies. Consequently, there is inconsistency in the classification of frailty and predictive capacity depending on the frailty assessment method utilised. We aimed to examine the diagnostic accuracy of several screening tools for frailty defined by the phenotype model in older Japanese adults. Methods This cross-sectional study included 1,306 older Japanese adults aged ≥ 65 years who underwent physical check-up by cluster random sampling as part of the Kyoto-Kameoka Study in Japan. We evaluated the diagnostic accuracy of several screening instruments for frailty using the revised Japanese version of the Cardiovascular Health Study criteria as the reference standard. These criteria are based on the Fried phenotype model and include five elements: unintentional weight loss, weakness (grip strength), exhaustion, slowness (normal gait speed), and low physical activity. The Kihon Checklist (KCL), frailty screening index (FSI), and self-reported health were evaluated using mailed surveys. We calculated the non-parametric area under the receiver operating characteristic curve (AUC ROC) for several screening tools against the reference standard. Results The participants’ mean (standard deviation) age was 72.8 (5.5) years. The prevalence of frailty based on the Fried phenotype model was 12.2% in women and 10.3% in men. The AUC ROC was 0.861 (95% confidence interval: 0.832–0.889) for KCL, 0.860 (0.831–0.889) for FSI, and 0.668 (0.629–0.707) for self-reported health. The cut-off for identifying frail individuals was ≥ 7 points in the KCL and ≥ 2 points in the FSI. Conclusions Our results indicated that the two instruments (KCL and FSI) had sufficient diagnostic accuracy for frailty based on the phenotype model for older Japanese adults. This may be useful for the early detection of frailty in high-risk older adults.
Variation in human water turnover associated with environmental and lifestyle factors. International-journal

Yosuke Yamada, Xueying Zhang, Mary E T Henderson, Hiroyuki Sagayama, Herman Pontzer, Daiki Watanabe, Tsukasa Yoshida, Misaka Kimura, Philip N Ainslie, Lene F Andersen, Liam J Anderson, Lenore Arab, Issad Baddou, Kweku Bedu-Addo, Ellen E Blaak, Stephane Blanc, Alberto G Bonomi, Carlijn V C Bouten, Pascal Bovet, Maciej S Buchowski, Nancy F Butte, Stefan G Camps, Graeme L Close, Jamie A Cooper, Richard Cooper, Sai Krupa Das, Lara R Dugas, Simon Eaton, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W Fudge, Annelies H Goris, Michael Gurven, Lewis G Halsey, Catherine Hambly, Asmaa El Hamdouchi, Marije B Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M Joosen, Peter Katzmarzyk, Kitty P Kempen, William E Kraus, Wantanee Kriengsinyos, Robert F Kushner, Estelle V Lambert, William R Leonard, Nader Lessan, Corby K Martin, Anine C Medin, Erwin P Meijer, James C Morehen, James P Morton, Marian L Neuhouser, Theresa A Nicklas, Robert M Ojiambo, Kirsi H Pietiläinen, Yannis P Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L Prentice, Roberto A Rabinovich, Susan B Racette, David A Raichlen, Eric Ravussin, Leanne M Redman, John J Reilly, Rebecca M Reynolds, Susan B Roberts, Albertine J Schuit, Luis B Sardinha, Analiza M Silva, Anders M Sjödin, Eric Stice, Samuel S Urlacher, Giulio Valenti, Ludo M Van Etten, Edgar A Van Mil, Jonathan C K Wells, George Wilson, Brian M Wood, Jack A Yanovski, Alexia J Murphy-Alford, Cornelia U Loechl, Amy H Luke, Jennifer Rood, Klaas R Westerterp, William W Wong, Motohiko Miyachi, Dale A Schoeller, John R Speakman

Science (New York, N.Y.)　378　(6622)　909-915　2022/11/25

DOI： 10.1126/science.abm8668 　

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Water is essential for survival, but one in three individuals worldwide (2.2 billion people) lacks access to safe drinking water. Water intake requirements largely reflect water turnover (WT), the water used by the body each day. We investigated the determinants of human WT in 5604 people from the ages of 8 days to 96 years from 23 countries using isotope-tracking (2H) methods. Age, body size, and composition were significantly associated with WT, as were physical activity, athletic status, pregnancy, socioeconomic status, and environmental characteristics (latitude, altitude, air temperature, and humidity). People who lived in countries with a low human development index (HDI) had higher WT than people in high-HDI countries. On the basis of this extensive dataset, we provide equations to predict human WT in relation to anthropometric, economic, and environmental factors.
Doubly labelled water-calibrated energy intake associations with mortality risk among older adults. International-journal

Daiki Watanabe, Tsukasa Yoshida, Yuya Watanabe, Misaka Kimura, Yosuke Yamada

Journal of cachexia, sarcopenia and muscle　14　(1)　214-225　2022/11/25

DOI： 10.1002/jcsm.13122 　

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BACKGROUND: The body mass index (BMI) is closely related to mortality risk, and energy intake (EI) is essential for maintaining energy balance in weight control. However, self-reported EI has been shown to lead to a systematic underestimation. Total energy expenditure measured using the doubly labelled water (DLW) method is considered an objective biomarker of EI and the gold standard for its estimation in individuals with stable body weight. We aimed to examine the association between DLW-calibrated EI and BMI on overall mortality risk in older adults. METHODS: A prospective cohort study was performed using data of 8051 (4267 women and 3784 men) Japanese older adults from the Kyoto-Kameoka Study in Japan. Calibrated EI was calculated from the estimated EI using a food frequency questionnaire and equation developed based on DLW. Participants were classified by quartiles based on their EI stratified by sex. BMI was calculated using self-reported height and body weight. Mortality data were collected between 30 July 2011 and 30 November 2016. Statistical analysis was performed using the multivariable-adjusted Cox proportional hazard model with a restricted cubic spline. RESULTS: The 8051 participants' mean (standard deviation) age and BMI were 73.5 (6.1) years and 22.6 (3.0) kg/m2 , respectively. The mean (standard deviation) EI with and without calibration was 1909 (145) kcal/day and 1569 (358) kcal/day in women and 2383 (160) kcal/day and 1980 (515) kcal/day in men, respectively. During the median 4.75 years of follow-up (36 552 person-years), 661 deaths were recorded. In both women (hazard ratio [HR], 0.63; 95% confidence interval [CI] [0.41, 0.98]) and men (HR, 0.62; 95% CI [0.44, 0.87]), after adjusting for confounders, the top quartile as compared with the bottom calibrated EI quartile showed a negative association with risk of all-cause mortality. The lowest HR for all-cause mortality was 1900-2000 kcal/day in women and 2400-2600 kcal/day in men. However, after adjusting for BMI, no significant association was observed between the calibrated EI and the risk of death. These associations could not be confirmed in the uncalibrated EI. The HR for mortality was minimal at a BMI of 23 kg/m2 in both men and women, with or without adjustment for the calibrated EI. CONCLUSIONS: Calibrated EI was negatively associated with mortality risk but not uncalibrated EI. This may be mediated by an increase in body weight over time. Caution is required when interpreting the association between EI and mortality risk without adjusting for self-reported measurement errors and outcomes.
Skeletal muscle mass can be estimated by creatine (methyl-d3) dilution and is correlated with fat-free mass in active young males. International-journal

Hiroyuki Sagayama, Yosuke Yamada, Emi Kondo, Yoko Tanabe, Akiko Uchizawa, Mahalakshmi Shankaran, Edna Nyangau, William J Evans, Marc Hellerstein, Jun Yasukata, Yasuki Higaki, Takahiro Ohnishi, Hideyuki Takahashi

European journal of clinical nutrition　2022/11/14

DOI： 10.1038/s41430-022-01237-9 　

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BACKGROUND: Assessing whole-body skeletal muscle mass (SMM) and fat-free mass (FFM) is essential for the adequate nutritional management and training evaluation of athletes and trained individuals. This study aimed to determine the relationship between SMM assessed using the creatine (methyl-d3) dilution (D3-creatine) method and SMM estimated by whole-body magnetic resonance imaging (MRI) in healthy young men undergoing exercise training. Additionally, we examined the association between FFM measured using the four-component (4C) method (FFM4C) and the total body protein value estimated using 4C (TBpro4C). METHODS AND RESULTS: We analyzed the data of 29 males (mean age, 19.9 ± 1.8 years) who exercised regularly. SMM measurements were obtained using the D3-creatine method (SMMD3-creatine) and MRI (SMMMRI). The SMMD3-creatine adjusted to 4.3 g/SMM kg was significantly higher than SMMMRI (p < 0.01). The fit of the creatine pool size compared with SMMMRI was 5.0 g/SMMMRI kg. SMMMRI was significantly correlated with both SMMD3-creatine adjusted to 4.3 g/kg and 5.1 g/kg. TBpro4C was significantly lower than SMMMRI (p < 0.01). Contrastingly, FFM4C was significantly higher than SMMMRI (p < 0.01). CONCLUSIONS: SMMD3-creatine adjusted to 4.3 g/SMM kg-a previously reported value-may differ for athletes and active young males. We believe that a value of 5.0-5.1 g/SMM kg better estimates the total muscle mass in this population. Traditional FFM estimation highly correlates with SMMMRI in well-trained young males, and the relationships appear strong enough for total body protein or SMM to be estimated through the FFM value.
Phase angle obtained via bioelectrical impedance analysis and objectively measured physical activity or exercise habits. International-journal

Yosuke Yamada, Tsukasa Yoshida, Haruka Murakami, Ryoko Kawakami, Yuko Gando, Harumi Ohno, Kumpei Tanisawa, Kana Konishi, Tripette Julien, Emi Kondo, Takashi Nakagata, Hinako Nanri, Motohiko Miyachi

Scientific reports　12　(1)　17274-17274　2022/10/14

DOI： 10.1038/s41598-022-21095-6 　

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The phase angle (PhA), measured via bioelectrical impedance analysis, is considered an indicator of cellular health, where higher values reflect higher cellularity, cell membrane integrity, and better cell function. This study aimed to examine the relationship between PhA and exercise habits or objectively measured physical activity. We included 115 people aged 32-69 years. The body composition and PhA were measured using a bioelectrical impedance device. Physical activity and sedentary behavior (SB) were assessed using a triaxial accelerometer. Exercise habits were also obtained through structured interviews, and participants were categorized into the no exercise habit (No-Ex), resistance training exercise habit (RT), or aerobic training exercise habit (AT) groups. Objectively measured moderate-to-vigorous physical activity or step count significantly correlated with PhA, independent of age, sex, height, percent body fat, body cell mass, and leg muscle power. In contrast, SB was not significant determinants of PhA. People who exercised regularly (RT or AT) had significantly higher PhA values than did those in the No-Ex group. Furthermore, the PhA was not significantly different between the RT and AT groups. Regularly engaging in exercise with moderate-to-vigorous intensity may improve or maintain muscle cellular health and muscle quality.
【「健康寿命」を延ばす職域での取り組み】総論健康寿命延伸における職域の役割フレイル予防・対策からの安全・健康づくり

岩坂知治, 山田陽介, 吉田司, 南里妃名子, 中潟崇, 小野玲

安全と健康　73　(10)　953-957　2022/10
Publisher: 中央労働災害防止協会
ISSN： 1881-0462
Variability in energy expenditure is much greater in males than females

Lewis G. Halsey, Vincent Careau, Herman Pontzer, Philip N. Ainslie, Lene F. Andersen, Liam J. Anderson, Lenore Arab, Issad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V.C. Bouten, Pascal Bovet, Maciej S. Buchowski, Nancy F. Butte, Stefan G.J.A. Camps, Graeme L. Close, Jamie A. Cooper, Sai Krupa Das, Richard Cooper, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marije B. Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M. Joosen, Peter Katzmarzyk, Kitty P. Kempen, Misaka Kimura, William E. Kraus, Robert F. Kushner, Estelle V. Lambert, William R. Leonard, Nader Lessan, Corby K. Martin, Anine C. Medin, Erwin P. Meijer, James C. Morehen, James P. Morton, Marian L. Neuhouser, Theresa A. Nicklas, Robert M. Ojiambo, Kirsi H. Pietiläinen, Yannis P. Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L. Prentice, Roberto A. Rabinovich, Susan B. Racette, David A. Raichlen, Eric Ravussin, Rebecca M. Reynolds, Susan B. Roberts, Albertine J. Schuit, Anders M. Sjödin, Eric Stice, Samuel S. Urlacher, Giulio Valenti, Ludo M. Van Etten, Edgar A. Van Mil, George Wilson, Brian M. Wood, Jack Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J. Murphy-Alford, Cornelia U. Loechl, Amy H. Luke, Jennifer Rood, Hiroyuki Sagayama, Dale A. Schoeller, Klaas R. Westerterp, William W. Wong, Yosuke Yamada, John R. Speakman

Journal of Human Evolution　171　103229-103229　2022/10
Publisher: Elsevier BV
DOI： 10.1016/j.jhevol.2022.103229 　

ISSN： 0047-2484
Time trend changes in the amount and type of physical activities over a 20-year period in urban elementary school sixth-graders

Aya Itoi, Yosuke Yamada, Misaka Kimura

Japanese Journal of Physical Fitness and Sports Medicine　71　(5)　401-415　2022/10/01
Publisher: The Japanese Society of Physical Fitness and Sports Medicine
DOI： 10.7600/jspfsm.71.401 　

ISSN： 0039-906X

eISSN： 1881-4751
Combined use of sleep quality and duration is more closely associated with mortality risk among older adults: a population-based Kyoto-Kameoka prospective cohort study.

Daiki Watanabe, Tsukasa Yoshida, Yuya Watanabe, Yosuke Yamada, Motohiko Miyachi, Misaka Kimura, Kyoto-Kameoka Study Group

Journal of epidemiology　2022/09/24

DOI： 10.2188/jea.JE20220215 　

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BACKGROUND: Whether sleep quality and duration-combination assessed from multiple domains are strongly associated with mortality risk in older adults remains unelucidated. We aimed to clarify these relationships. METHODS: We enrolled 7,668 older (age ≥65) Japanese adults in the Kyoto-Kameoka prospective cohort study who provided valid responses to the Pittsburgh Sleep Quality Index (PSQI) in a mail-in survey. Sleep quality and duration were classified into six groups using previously validated PSQI: short sleep duration (SSD: <360 min/day)/sleep disturbance (SD: ≥5.5 PSQI points), n=701; SSD/non-sleep disturbance (NSD: <5.5 PSQI points), n=100; optimal sleep duration (OSD: 360-480 min/day)/NSD, n=1863; OSD/SD, n=2113; long sleep duration (LSD: >480 min/day)/NSD, n=1972; LSD/SD, n=919. Mortality data were collected from February 15, 2012, to November 30, 2016. We evaluated the relationship between all-cause mortality risk and sleep quality and duration-combination using a multivariable Cox proportional hazards model that included baseline covariates. RESULTS: The median follow-up period was 4.75 years (34,826 person-years), with a total of 616 deaths. After adjusting for confounders, compared with other groups, SSD/SD and LSD/SD had the highest hazard ratio (HR) of mortality [SSD/SD: HR, 1.56 (95% confidence interval [CI]: 1.10-2.19); SSD/NSD: HR, 1.27 (95%CI: 0.47-3.48); OSD/NSD: reference; OSD/SD: HR, 1.20 (95%CI: 0.91-1.59); LSD/NSD: HR, 1.35 (95%CI: 1.03-1.77); LSD/SD: HR, 1.83 (95%CI: 1.37-2.45)]. However, mortality risk was not associated with the interaction between sleep quality and duration. CONCLUSIONS: Older adults with sleep disturbances involving SSD and LSD have a strong positive association with mortality risk, suggesting an additive effect between sleep quality and duration.
Association of the interaction between physical activity and sitting time with mortality in older Japanese adults

Daiki Watanabe, Yosuke Yamada, Tsukasa Yoshida, Yuya Watanabe, Yoichi Hatamoto, Hiroyuki Fujita, Motohiko Miyachi, Misaka Kimura

Scandinavian Journal of Medicine & Science in Sports　2022/09/16
Publisher: Wiley
DOI： 10.1111/sms.14234 　

ISSN： 0905-7188

eISSN： 1600-0838
Combined use of two frailty tools in predicting mortality in older adults. International-journal

Daiki Watanabe, Tsukasa Yoshida, Yosuke Yamada, Yuya Watanabe, Minoru Yamada, Hiroyuki Fujita, Motohiko Miyachi, Hidenori Arai, Misaka Kimura

Scientific reports　12　(1)　15042-15042　2022/09/03

DOI： 10.1038/s41598-022-19148-x 　

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We aimed to verify the combined use of two frailty tools in predicting mortality in older adults. We used the data of 10,276 Japanese older adults (aged ≥ 65 years) who provided valid responses to two frailty assessment tools in a mail survey in Japan's Kyoto‒Kameoka Prospective cohort study. Frailty status was categorized into four groups depending on the validated frailty screening index and Kihon Checklist, respectively: Non-frailty (n = 5960), Physical frailty (n = 223), Comprehensive frailty (n = 2211), and Combination (n = 1882) groups. Mortality data were collected between July 30, 2011, and November 30, 2016. We assessed the relationship between frailty status and all-cause mortality risk using multivariate Cox proportional hazards models. During a median follow-up of 5.3 years, we recorded 1257 deaths. After adjusting for confounders, the Combination group had the highest mortality risk compared with the other groups [Non-frailty: reference; Physical frailty: hazards ratio [HR], 0.99 (95% confidence interval [CI] 0.58 to 1.70); Comprehensive frailty: 1.91 (1.63 to 2.23); Combination: 2.85 (2.44 to 3.22)]. People who are positive for frailty in both instruments have a higher risk of death than those who are positive to one model.
Can phase angle from bioelectrical impedance analysis associate with neuromuscular properties of the knee extensors?

Kosuke Hirata, Mari Ito, Yuta Nomura, Tsukasa Yoshida, Yosuke Yamada, Ryota Akagi

Frontiers in Physiology　13　2022/08/11
Publisher: Frontiers Media SA
DOI： 10.3389/fphys.2022.965827 　

eISSN： 1664-042X

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Maintenance and improvement of neuromuscular functions is crucial for everyone regardless of age. An easy way to assess neuromuscular properties without muscle contraction is useful especially for those who cannot perform strenuous muscular force production, such as older adults and patients with orthopedic or cognitive disorders. Bioelectrical impedance analysis (BIA) can assess body electrical properties e.g., phase angle (PhA) which is regarded as muscle quantity/quality index. The purpose of this study was to investigate associations of PhA with neuromuscular properties of the knee extensors in 55 young (n = 23) and older (n = 32) adults. The values of PhA of the right thigh and whole-body were determined with BIA at 50 kHz. The participants performed 4-s maximal voluntary isometric contraction (MVIC) to measure peak torque (PT_MVIC), and 1-s brief MVIC to assess rate of torque development (RTD) over the time interval of 0–200 ms. As markers of physiological mechanisms of muscle force production, twitch contractile properties (peak twitch torque, rate of twitch torque development, and time-to-peak twitch torque) of the knee extensors obtained by femoral nerve electrical stimulation, and muscle activity assessed as root mean square values of electromyographic activity (EMG-RMS) during PT_MVIC and RTD measurements were measured. Thigh and whole-body PhA significantly correlated with PT_MVIC (r ≥ 0.555, p &lt; 0.001) and electrically evoked twitch parameters (peak twitch torque, rate of twitch torque development, and time-to-peak twitch torque; |r| ≥ 0.420, p ≤ 0.001), but not RTD (r ≤ 0.237, p ≥ 0.081) or EMG-RMSs (|r| ≤ 0.214, p ≥ 0.117). Stepwise multiple linear regression analysis revealed that thigh PhA was selected as a significant variable to predict PT_MVIC but not RTD. Whole-body PhA was not selected as a significant variable to predict PT_MVIC or RTD. In conclusion, both thigh and whole-body PhA can associate with maximal voluntary muscle strength of the knee extensors, and this association may be due to intrinsic contractile properties but not neural aspects. Regarding prediction of the knee extensor strength, thigh PhA is preferable as the predictor rather than whole-body PhA which is used as a widely acknowledged indicator of sarcopenia.
Correction: Age- and sex-related differences of muscle cross-sectional area in iliocapsularis: a cross-sectional study. International-journal

Masahide Yagi, Masashi Taniguchi, Hiroshige Tateuchi, Tetsuya Hirono, Yoshihiro Fukumoto, Momoko Yamagata, Ryusuke Nakai, Yosuke Yamada, Misaka Kimura, Noriaki Ichihashi

BMC geriatrics　22　(1)　657-657　2022/08/10

DOI： 10.1186/s12877-022-03281-3 　
Step-count outcomes of 13 different activity trackers: results from laboratory and free-living experiments

Takashi Nakagata, Haruka Murakami, Ryoko Kawakami, Julien Tripette, Satoshi Nakae, Yosuke Yamada, Kazuko Ishikawa-Takata, Shigeho Tanaka, Motohiko Miyachi

Gait & Posture　2022/08
Publisher: Elsevier BV
DOI： 10.1016/j.gaitpost.2022.08.004 　

ISSN： 0966-6362
Membrane capacitance and characteristic frequency are associated with contractile properties of skeletal muscle

Yosuke Yamada, Kosuke Hirata, Natsuki Iida, Akihiro Kanda, Mikio Shoji, Tsukasa Yoshida, Motohiko Myachi, Ryota Akagi

Medical Engineering & Physics　106　103832-103832　2022/08
Publisher: Elsevier BV
DOI： 10.1016/j.medengphy.2022.103832 　

ISSN： 1350-4533
Muscle quality indices separately associate with joint-level power-related measures of the knee extensors in older males

Kosuke Hirata, Mari Ito, Yuta Nomura, Chiho Kawashima, Yuma Tsuchiya, Kosuke Ooba, Tsukasa Yoshida, Yosuke Yamada, Geoffrey A. Power, Neale A. Tillin, Ryota Akagi

European Journal of Applied Physiology　122　(10)　2271-2281　2022/07/18
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s00421-022-05005-2 　

ISSN： 1439-6319

eISSN： 1439-6327

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Abstract Purpose The purpose of this study was to investigate associations of muscle quality indices with joint-level power-related measures in the knee extensors of thirty-two older males (65–88 years). Methods Muscle quality indices included: echo intensity, ratio of intracellular- to total water content (ICW/TW), and specific muscle strength. Echo intensity was acquired from the rectus femoris (EI_RF) and vastus lateralis (EI_VL) by ultrasonography. ICW/TW was computed from electrical resistance of the right thigh obtained by bioelectrical impedance spectroscopy. Specific muscle strength was determined as the normalized maximal voluntary isometric knee extension (MVIC) torque to estimated knee extensor volume. Isotonic maximal effort knee extensions with a load set to 20% MVIC torque were performed to obtain the knee extension power-related measures (peak power, rate of power development [RPD], and rate of velocity development [RVD]). Power and RPD were normalized to MVIC. Results There were no significant correlations between muscle quality indices except between EI_RF and EI_VL (|r|≤ 0.253, P ≥ 0.162). EI_RF was negatively correlated with normalized RPD and RVD (r ≤ − 0.361, P ≤ 0.050). ICW/TW was positively correlated with normalized peak power (r = 0.421, P = 0.020). Specific muscle strength was positively correlated with absolute peak power and RPD (r ≥ 0.452, P ≤ 0.012). Conclusion Knee extension power-related measures were lower in participants with higher EI, lower ICW/TW, and lower specific muscle strength, but the muscle quality indices may be determined by independent physiological characteristics.
Influence of ultrasound focus depth on the association between echo intensity and intramuscular adipose tissue. International-journal

Yoshihiro Fukumoto, Masashi Taniguchi, Tetsuya Hirono, Masahide Yagi, Momoko Yamagata, Ryusuke Nakai, Tsuyoshi Asai, Yosuke Yamada, Misaka Kimura, Noriaki Ichihashi

Muscle & nerve　66　(5)　568-575　2022/07/13

DOI： 10.1002/mus.27677 　

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INTRODUCTION/AIMS: Attenuation of the US wave is a serious limitation of echo intensity (EI) on B-mode ultrasound (US). The aim of this study was to determine if the focus depth of US images influences the depth-dependent attenuation of EI and the relationship between EI and intramuscular adipose tissues (IntraMAT). METHODS: The rectus femoris (RF) and vastus intermedius (VI) of the right thigh were studied in 135 adults (92 older, 43 younger). The EI on US images was measured at three focus depth conditions: top of the image, center of the RF, and center of the VI. The depth of the region of interest (ROI) was measured. Using water and fat images based on the two-point Dixon technique with 3.0 T MRI scanner, IntraMAT was calculated. RESULTS: The correlation between EI and IntraMAT was stronger in the focus RF and VI conditions than in the focus top condition and stronger for RF than for VI. The depth of the ROI influenced the IntraMAT-adjusted residual EI more in the focus top condition than in the focus RF and VI conditions, and influenced VI more strongly than it did RF. DISCUSSION: This study showed that by mitigating EI attenuation, EI with a focus depth adjusted to the ROI reflected IntraMAT more accurately than that without adjustment. However, it may not completely prevent the potential influence of depth-dependent attenuation of EI, especially for deeper muscles such as the VI. This article is protected by copyright. All rights reserved.
加速度計で調査した地域在住高齢者の身体活動福岡那珂川研究

古瀬裕次郎, 武田典子, 池永昌弘, 山田陽介, 森村和浩, 木村みさか, 清永明, 檜垣靖樹

運動疫学研究: Research in Exercise Epidemiology　24　(1)　52-53　2022/06
Publisher: 日本運動疫学会
ISSN： 1347-5827

eISSN： 2434-2017
Regional Difference in the Impact of COVID-19 Pandemic on Domain-Specific Physical Activity, Sedentary Behavior, Sleeping Time, and Step Count: An Online Cross-sectional Nationwide Survey and an Accelerometer-based Observational Study (Preprint) International-journal

Yosuke Yamada, Hideyuki Namba, Heiwa Date, Shinobu Kitayama, Yui Nakayama, Misaka Kimura, Hiroyuki Fujita, Motohiko Miyachi

JMIR Public Health and Surveillance　9　e39992　2022/05/31
Publisher: JMIR Publications Inc.
DOI： 10.2196/39992 　

eISSN： 2369-2960

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BACKGROUND: Physical activity (PA) and sedentary behavior (SB) have been affected by the COVID-19 pandemic and its restrictive environments, such as social distancing and lockdown measures. However, regional differences in the changes in domain-specific PA and SB in response to the COVID-19 pandemic are not clearly understood. OBJECTIVE: This study aimed to examine regional differences in domain-specific PA and SB, as well as sleeping time in response to the COVID-19 pandemic in Japan. METHODS: A web-based cross-sectional nationwide survey and an accelerometer-based longitudinal observation were conducted. In the web-based survey, we recruited 150 Japanese men and 150 Japanese women for each of the following age groups: 20s, 30s, 40s, 50s, 60s, and 70s (n=1800). A total of 1627 adults provided valid responses to web-based surveillance from June to July 2020. Participants were recruited from urban (Greater Tokyo Area, n=1028), urban-rural (regional core cities, n=459), or rural (regional small and medium cities, n=140) areas. They answered sociodemographic and health-related questions and retrospectively registered the PA data of their average day before and during the COVID-19 pandemic in a web-based PA record system. In the accelerometer-based observation, PA and step count data were obtained using a triaxial accelerometer on people living in urban (n=370) and rural (n=308) areas. RESULTS: Before the COVID-19 pandemic, there were no significant differences between these 3 regions in the time spent sleeping, staying at home, working or studying, and exercising (P>.05). By contrast, people living in urban areas had a longer duration of SB and transportation and a shorter duration of moderate-to-vigorous PA and lying or napping time compared with people living in rural areas (P>.05). During the COVID-19 pandemic, a significant decrease was observed in transportation time in urban (-7.2 min/day, P<.001) and urban-rural (-2.0 min/day, P=.009) areas but not in rural (-0.4 min/day, P=.52) areas. The moderate-to-vigorous PA was decreased in urban (-31.3 min/day, P<.001) and urban-rural (-30.0 min/day, P<.001) areas but not in rural areas (-17.3 min/day, P=.08). A significant increase was observed in time spent sleeping in urban (+22.4 min/day, P<.001) and urban-rural (+24.2 min/day, P<.001) but not in rural areas (+3.9 min/day, P=.74). Lying or napping was increased in urban (+14.9 min/day, P<.001) but not in rural areas (-6.9 min/day, P=.68). PA and step count obtained using an accelerometer significantly decreased in urban (P<.05) but not in rural areas (P>.05). CONCLUSIONS: The effect of the COVID-19 pandemic on PA and SB was significantly dependent on living area, even in a single country. The effects of PA and SB were greater in the Greater Tokyo Area and regional core cities but were not observed in regional small and medium cities in Japan.
Age- and sex-related differences of muscle cross-sectional area in iliocapsularis: a cross-sectional study. International-journal

Masahide Yagi, Masashi Taniguchi, Hiroshige Tateuchi, Tetsuya Hirono, Yoshihiro Fukumoto, Momoko Yamagata, Ryusuke Nakai, Yosuke Yamada, Misaka Kimura, Noriaki Ichihashi

BMC geriatrics　22　(1)　435-435　2022/05/18

DOI： 10.1186/s12877-022-03127-y 　

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BACKGROUND: This study aimed to determine in how many individuals the iliocapsularis muscle (IC) could be identified on magnetic resonance imaging (MRI) and whether age and sex are associated with the cross-sectional area (CSA) of the IC. METHODS: Thirty-seven healthy younger adults and 40 healthy older adults were assigned to four groups: 1) 20 younger men; 2) 17 younger women; 3) 20 older men; and 4) 20 older women. The CSAs of the IC, IP, the rectus femoris (RF) and the quadriceps (QUAD) were quantified on an axial MRI. RESULTS: The number of individuals with the identified IC was n = 17 (85.0%) of 20 younger men, n = 15 (88.2%) of 17 younger women, n = 18 (90.0%) of 20 older men, and 19 (95.0%) of 20 older women. Our results showed the main effect of sex, but not age, in the CSA of the IC. The men-groups had larger CSA of the IC than the women-groups; however, no difference in CSA of the IC was found between the younger and older groups. Meanwhile, the main effects of age and sex were found for the IP, RF, and QUAD; thus, younger or men groups have larger CSAs of the three muscles than the older or women groups. The IC muscle can be discriminated in 85% - 95% of healthy individuals. CONCLUSION: Although sex and age are associated with the CSA of lower-limb muscles other than the IC, only sex is associated with the CSA of the IC.
Weight over-reporting is associated with low muscle mass among community-dwelling Japanese adults aged 40 years and older: a cross sectional study. International-journal

Takashi Nakagata, Tsukasa Yoshida, Daiki Watanabe, Yukako Arishima-Hashii, Yosuke Yamada, Naomi Sawada, Hidekazu Shimada, Nobuo Nishi, Motohiko Miyachi

Journal of physiological anthropology　41　(1)　19-19　2022/05/05

DOI： 10.1186/s40101-022-00292-2 　

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BACKGROUND: Weight misperception adversely affects health-related quality of life (HRQol); however, few studies have evaluated the relationship between weight misperception and muscle mass. This study aimed to examine the relationship of weight misperception with low muscle mass using skeletal muscle index (SMI) estimated by multifrequency bioelectrical impedance analysis (MF-BIA) among community-dwelling Japanese. METHODS: Participants were 525 Japanese individuals aged 40-91 years old (male 89, female 436). Misperception was calculated by subtracting measured value from self-reported weight, presented as a percentage and categorized into tertiles based on sex (under-reporters, acceptable reporters, and over-reporters). Appendicular lean mass was estimated using MF-BIA, and low muscle mass was defined using SMI values of 7.0 and 5.7 kg/m2 for males and females, respectively, based on the Asian Working Group for Sarcopenia 2019 consensus. We evaluated the association between prevalence of low muscle mass and weight misperception (under-reporters and over-reporters) using multivariate logistic regression including covariate. RESULTS: In total, 9.3% (49/525) of participants had low muscle mass. After adjusting for covariates, prevalence of low muscle mass was higher among over-reporters than acceptable-reporters (odds ratio [OR]; 2.37, 95% confidence interval [CI]; 1.03-5.44). Additionally, sensitivity analysis was performed on females, which confirmed that the prevalence of low muscle mass was higher in over-reporters than in acceptable-reporters (OR, 3.27; 95% CI, 1.18-9.12). CONCLUSION: Weight misperception was significantly correlated with low muscle mass, especially in over-reporters.
Dose-Response Relationship Between Life-Space Mobility and Mortality in Older Japanese Adults: A Prospective Cohort Study

Daiki Watanabe, Tsukasa Yoshida, Yosuke Yamada, Yuya Watanabe, Minoru Yamada, Hiroyuki Fujita, Tomoki Nakaya, Motohiko Miyachi, Hidenori Arai, Misaka Kimura

Journal of the American Medical Directors Association　23　(11)　1869.e7-1869.e18　2022/05
Publisher: Elsevier BV
DOI： 10.1016/j.jamda.2022.04.017 　

ISSN： 1525-8610
Relationship between Measured Aerobic Capacity and Total Energy Expenditure Obtained by the Doubly Labeled Water Method in Community-Dwelling, Healthy Adults Aged 81-94 Years. International-journal

Jun Yasukata, Yosuke Yamada, Hiroyuki Sagayama, Yasuki Higaki, Hiroaki Tanaka

Geriatrics (Basel, Switzerland)　7　(2)　2022/04/15

DOI： 10.3390/geriatrics7020048 　

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The doubly labeled water method is a gold-standard method for the measurement of total energy expenditure in daily life. We aimed to identify the relationship between measured aerobic capacity and total energy expenditure, activity energy expenditure, or physical activity level using the doubly labeled water method in adults of advanced old age. A total of 12 physically independent older adults (10 men and 2 women), aged 81-94 years, participated in this study. The aerobic capacity was evaluated according to the lactate threshold. Total energy expenditure under free-living conditions was assessed using the doubly labeled water method, and self-reported physical activity was obtained using the Japanese version of the International Physical Activity Questionnaire. The lactate threshold was significantly positively correlated with total energy expenditure, activity energy expenditure, and physical activity level after adjusting for age and sex. We found that the aerobic capacity of the lactate threshold was positively and independently correlated with total energy expenditure, activity energy expenditure, or physical activity level. The present results suggest that maintaining aerobic capacity is an important factor in preventing frailty, although further research is required.
Association of age-related decrease in intracellular-to-total water ratio with that in explosive strength of the plantar flexors: a cross-sectional study. International-journal

Kosuke Hirata, Natsuki Iida, Akihiro Kanda, Mikio Shoji, Tsukasa Yoshida, Yosuke Yamada, Ryota Akagi

Journal of physiological anthropology　41　(1)　10-10　2022/03/26

DOI： 10.1186/s40101-022-00284-2 　

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BACKGROUND: We aimed to investigate the association of age-related differences in the intracellular-to-total water ratio with explosive strength of the plantar flexors. METHODS: A total of 60 young (21-33 years) and older (64-83 years) individuals were recruited. Intracellular- (ICW) and total-water (TW) content within the right leg was evaluated by bioelectrical impedance spectroscopy as indicators of muscle cell mass and whole muscle mass within the segment, respectively. ICW divided by TW (ICW/TW) was calculated as an index of the occupancy of muscle cells within whole muscle. Rate of torque development (RTD) and electromyography (EMG) activity during maximal voluntary isometric plantar flexion were measured as indicators of explosive muscle strength and neuromuscular activity, respectively. RTD was calculated from three time windows of 0-50, 50-100, and 100-200 ms. Time-to-peak torque (TPT) was assessed from evoked twitch contraction. RESULTS: Compared with young participants, older participants showed lower ICW/TW (-7%, P < 0.001), RTD (-25 to -40%, P = 0.003 to 0.001), and longer TPT (+11%, P < 0.001). ICW/TW associated positively with RTD (r = 0.377 to 0.408, P = 0.004 to 0.001) and negatively with TPT (r = -0.392, P = 0.002), but not with EMG activity. RTD was associated positively with EMG for each time window (r = 0.527 to 0.607, P < 0.001). CONCLUSIONS: These results indicate that ICW/TW may be a useful predictor of the age-related decrease in RTD, and that the decrease in ICW/TW with age may reflect age-associated changes in intrinsic contractile properties.
Effects of resistance training intensity on muscle quantity/quality in middle-aged and older people: a randomized controlled trial. International-journal

Yuta Otsuka, Yosuke Yamada, Akifumi Maeda, Takayuki Izumo, Tomohiro Rogi, Hiroshi Shibata, Masahiro Fukuda, Takuma Arimitsu, Naokazu Miyamoto, Takeshi Hashimoto

Journal of cachexia, sarcopenia and muscle　13　(2)　894-908　2022/02/20

DOI： 10.1002/jcsm.12941 　

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BACKGROUND: A sarcopenia diagnosis is confirmed by the presence of low muscle quantity or quality under the 2018 revised definition by the European Working Group on Sarcopenia in Older People 2. Imaging methods [i.e. magnetic resonance imaging (MRI)], dual-energy X-ray absorptiometry (DXA), and bioelectrical impedance analysis are tools to evaluate muscle quantity or quality. The present study aimed to investigate whether and how low-intensity and moderate-intensity resistance training improved both muscle quantity and quality measured by MRI, DXA, and segmental bioelectrical impedance spectroscopy (S-BIS) in middle-aged and older people. METHODS: A single-blind, randomized, controlled trial was conducted. Community-dwelling people aged 50-79 years were randomly allocated to no exercise (no-Ex), low-intensity exercise (low-Ex), and moderate-intensity exercise (moderate-Ex) groups. Participants in the exercise groups performed resistance training for 24 weeks, with loads of 40% and 60% of one repetition maximum in the low-Ex and moderate-Ex groups, respectively. Cross-sectional area (CSA), lean mass, and muscle electrical properties on S-BIS were used to determine the effects of training interventions on muscle quantity and quality of the lower limbs. RESULTS: Fifty participants (no-Ex 17, age 63.5 ± 8.5 years, women 47.1%; low-Ex 16, age 63.6 ± 8.1 years, women 50.0%; moderate-Ex 17, age 63.5 ± 8.3 years, women 52.9%) completed the 24 week exercise intervention. For the primary outcome, significant intervention effects were found in thigh muscle CSA on MRI between the moderate-Ex and no-Ex groups (+6.8 cm2 , P < 0.01). Low-Ex for 24 weeks only increased quadriceps CSA (+2.3 cm2 , P < 0.05). The per cent change of thigh muscle CSA (+7.0%, P < 0.01) after 24 week moderate-Ex was higher than that of leg lean mass on DXA (+2.3%, P = 0.088). Moderate-Ex for 24 weeks also improved S-BIS electrical properties related to muscle quantity and quality, including the intracellular resistance index (+0.1 cm2 /Ω, P < 0.05), membrane capacitance (+0.7 nF, P < 0.05), and phase angle (+0.3 deg, P < 0.05); their changes were positively correlated with that of thigh muscle CSA (P < 0.01). CONCLUSIONS: Resistance exercise with moderate intensity improved muscle quantity and quality measured by MRI and S-BIS, whereas that with low intensity only increased muscle quantity in middle-aged and older people. The comparisons among the responses to exercise between the assessment methods indicate the greater value of MRI and S-BIS to measure changes of muscle quantity and quality than of lean mass measured by DXA for assessing the local effects of resistance training.
Diet quality and physical or comprehensive frailty among older adults. International-journal

Daiki Watanabe, Kayo Kurotani, Tsukasa Yoshida, Hinako Nanri, Yuya Watanabe, Heiwa Date, Aya Itoi, Chiho Goto, Kazuko Ishikawa-Takata, Misaka Kimura, Motohiko Miyachi, Yosuke Yamada

European journal of nutrition　2022/02/13

DOI： 10.1007/s00394-022-02819-w 　

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PURPOSE: While the association between diet quality and mortality has been previously demonstrated, the association between frailty and diet quality has not been evaluated well. This study aimed to investigate the association between diet quality and prevalence of both physical and comprehensive frailty, using two validated tools, in a community-based cohort of older adults. METHODS: We conducted cross-sectional analyses using baseline data of 7022 participants aged ≥ 65 years in the Kyoto-Kameoka study. Diet quality was assessed by calculating the adherence scores to the Japanese Food Guide Spinning Top using a validated questionnaire; the participants were stratified into quartile groups based on these scores. Physical and comprehensive frailty was assessed using the Fried phenotype model-based Frailty Screening Index and the Kihon Checklist, respectively. Multivariable logistic regression and the restricted cubic spline model were used to calculate odds ratios (ORs) and their 95% confidence intervals (CIs) for associations between adherence scores and frailty prevalence. RESULTS: Higher adherence scores signified a higher intake of vitamin C, vegetables, dairy products, and fruits. Physical and comprehensive frailty prevalence was 14.2 and 35.8%, respectively. In a multivariable adjusted model, compared with the bottom adherence score quartile, the top quartile was associated with lower ORs of physical (OR 0.64; 95% CI 0.52-0.80) and comprehensive frailty (OR 0.60; 95% CI 0.51-0.71). These relationships were similar to results in the spline model. CONCLUSIONS: This study shows an inverse dose-response relationship between diet quality and prevalence of both physical and comprehensive frailty in older adults.
Adequate Protein Intake on Comprehensive Frailty in Older Adults: Kyoto-Kameoka Study

Hinako Nanri, D. Watanabe, T. Yoshida, E. Yoshimura, Y. Okabe, M. Ono, T. Koizumi, H. Kobayashi, H. Fujita, M. Kimura, Y. Yamada

The journal of nutrition, health & aging　26　(2)　161-168　2022/02
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s12603-022-1740-9 　

ISSN： 1279-7707

eISSN： 1760-4788
How many food items must be consumed to meet the recommended dietary protein intake for older Japanese adults?

Daiki Watanabe, Tsukasa Yoshida, Aya Itoi, Hinako Nanri, Yosuke Yamada, Motohiko Miyachi, Misaka Kimura

Geriatrics & gerontology international　22　(2)　181-183　2022/02

DOI： 10.1111/ggi.14345 　
Impact of low relative skeletal muscle mass and power on the development of metabolic syndrome in Japanese women: a 7-year prospective study

Yosuke Yamada, Haruka Murakami, Ryoko Kawakami, Yuko Gando, Hinako Nanri, Takashi Nakagata, Daiki Watanabe, Tsukasa Yoshida, Yoichi Hatamoto, Eiichi Yoshimura, Kiyoshi Sanada, Nobuyuki Miyatake, Motohiko Miyachi

2022/01/30
Publisher: Cold Spring Harbor Laboratory
DOI： 10.1101/2022.01.27.22269435 　
Self-management processes, sedentary behavior, physical activity and dietary self-management behaviors: impact on muscle outcomes in continuing care retirement community residents. International-journal

Murad H Taani, Scott J Strath, Rachel Schiffman, Michael Fendrich, Amy Harley, Chi C Cho, Yosuke Yamada, Christine R Kovach

BMC geriatrics　22　(1)　48-48　2022/01/12

DOI： 10.1186/s12877-021-02691-z 　

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BACKGROUND: Despite the known benefits of non-sedentary behavior, physical activity, and protein and caloric intake to health and muscle mass, strength, and function, many older adults do not meet physical activity and dietary recommendations. A better understanding of the factors associated with sedentary behavior, physical activity and dietary self-management behaviors, and muscle outcomes (muscle mass, strength, and function) is needed, particularly among continuing care retirement community residents. The objective of this study was to examine the factors associated with sedentary behavior, physical activity and dietary self-management behaviors, and muscle outcomes among continuing care retirement community residents. It also aimed to determine whether sedentary behavior and physical activity and dietary self-management behaviors mediate the relationships between self-efficacy, goal congruence, aging expectations, social support, and muscle outcomes. METHODS: A sample of 105 continuing care retirement community residents (age > 70 years) participated in this correlational, cross-sectional study. Questionnaires on pain, self-efficacy, goal congruence, aging expectation, social support, and daily protein and caloric intake were administered. Physical activity and sedentary behavior (ActiGraph wGT3X-BT), muscle mass (ImpediMed SFB7), muscle strength (Jamar Smart Digital Hand Dynamometer), and muscle function (Short Physical Performance Battery) were measured. Multiple regression, logistic regression, and mediation analyses were performed. RESULTS: Low goal congruence predicted engagement in sedentary behavior and light physical activity. Higher levels of self-efficacy and social support were associated with increased likelihoods of achieving greater moderate physical activity and meeting daily recommendations for caloric intake, respectively. Self-efficacy and goal congruence predicted muscle function and strength. Moreover, sedentary behavior and achieving greater moderate physical activity were found to partially but significantly mediate the relationship between self-efficacy and muscle function. CONCLUSION: Future research should evaluate whether attempts to reduce sedentary behavior and promote physical activity and dietary self-management behaviors and muscle outcomes are more successful when modifications to the self-management process factors are also targeted.
Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition. International-journal

Rebecca Rimbach, Yosuke Yamada, Hiroyuki Sagayama, Philip N Ainslie, Lene F Anderson, Liam J Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E Blaak, Stephane Blanc, Alberto G Bonomi, Carlijn V C Bouten, Pascal Bovet, Maciej S Buchowski, Nancy F Butte, Stefan G J A Camps, Graeme L Close, Jamie A Cooper, Sai Krupa Das, Lara R Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W Fudge, Annelies H Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marije B Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M Joosen, Peter Katzmarzyk, Kitty P Kempen, Misaka Kimura, William E Kraus, Robert F Kushner, Estelle V Lambert, William R Leonard, Nader Lessan, Corby K Martin, Anine C Medin, Erwin P Meijer, James C Morehen, James P Morton, Marian L Neuhouser, Theresa A Nicklas, Robert M Ojiambo, Kirsi H Pietiläinen, Yannis P Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L Prentice, Roberto A Rabinovich, Susan B Racette, David A Raichlen, Eric Ravussin, Rebecca M Reynolds, Susan B Roberts, Albertine J Schuit, Anders M Sjödin, Eric Stice, Samuel S Urlacher, Giulio Valenti, Ludo M Van Etten, Edgar A Van Mil, Jonathan C K Wells, George Wilson, Brian M Wood, Jack Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J Murphy-Alford, Cornelia U Loechl, Amy H Luke, Jennifer Rood, Dale A Schoeller, Klaas R Westerterp, William W Wong, John R Speakman, Herman Pontzer

Nature communications　13　(1)　99-99　2022/01/10

DOI： 10.1038/s41467-021-27246-z 　

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Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight gain, but repeatability of TEE, a critical variable in longitudinal studies of energy balance, is understudied. We examine repeated doubly labeled water (DLW) measurements of TEE in 348 adults and 47 children from the IAEA DLW Database (mean ± SD time interval: 1.9 ± 2.9 y) to assess repeatability of TEE, and to examine if TEE adjusted for age, sex, fat-free mass, and fat mass is associated with changes in weight or body composition. Here, we report that repeatability of TEE is high for adults, but not children. Bivariate Bayesian mixed models show no among or within-individual correlation between body composition (fat mass or percentage) and unadjusted TEE in adults. For adults aged 20-60 y (N = 267; time interval: 7.4 ± 12.2 weeks), increases in adjusted TEE are associated with weight gain but not with changes in body composition; results are similar for subjects with intervals >4 weeks (N = 53; 29.1 ± 12.8 weeks). This suggests low TEE is not a risk factor for, and high TEE is not protective against, weight or body fat gain over the time intervals tested.
Effects of Quercetin Glycoside Supplementation Combined With Low-Intensity Resistance Training on Muscle Quantity and Stiffness: A Randomized, Controlled Trial. International-journal

Yuta Otsuka, Naokazu Miyamoto, Akitoshi Nagai, Takayuki Izumo, Masaaki Nakai, Masahiro Fukuda, Takuma Arimitsu, Yosuke Yamada, Takeshi Hashimoto

Frontiers in nutrition　9　912217-912217　2022

DOI： 10.3389/fnut.2022.912217 　

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OBJECTIVE: Aging of skeletal muscle is characterized not only by a decrease of muscle quantity but also by changes in muscle quality, such as an increase in muscle stiffness. The present study aimed to investigate the effects of supplementation with quercetin glycosides (QGs), well-known polyphenolic flavonoids, combined with resistance exercise on muscle quantity and stiffness. MATERIALS AND METHODS: A randomized, controlled trial was conducted in community-dwelling, Japanese people aged 50-74 years who were randomly allocated to exercise with placebo or 200 or 500 mg of QG supplementation. All participants performed low-intensity resistance training mainly targeting thigh muscles with 40% of 1-repetition maximum, 3 days per week for 24 weeks. Muscle cross-sectional area (CSA), lean mass, and vastus lateralis (VL) muscle stiffness were measured before and after the 24-week intervention. RESULTS: Forty-eight subjects completed the 24-week intervention. There were no significant group × time interactions in thigh CSA for primary outcome, as well as lean mass. VL muscle stiffness in the stretched position was significantly lower in both the 200 mg and 500 mg QG groups than in the placebo group after the 24-week intervention (p < 0.05). No significant correlation was observed between changes of VL muscle CSA and stiffness during the 24-week intervention. CONCLUSION: Quercetin glycoside supplementation combined with low-intensity resistance exercise improved passive muscle stiffness independently of muscle quantity. CLINICAL TRIAL REGISTRATION: [www.umin.ac.jp/ctr/], identifier [UMIN000037633].
Association between skeletal muscle mass or percent body fat and metabolic syndrome development in Japanese women: A 7-year prospective study. International-journal

Yosuke Yamada, Haruka Murakami, Ryoko Kawakami, Yuko Gando, Hinako Nanri, Takashi Nakagata, Daiki Watanabe, Tsukasa Yoshida, Yoichi Hatamoto, Eiichi Yoshimura, Kiyoshi Sanada, Nobuyuki Miyatake, Motohiko Miyachi

PloS one　17　(10)　e0263213　2022

DOI： 10.1371/journal.pone.0263213 　

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Previous cross-sectional studies have indicated that low relative appendicular lean mass (ALM) against body weight (divided by body weight, ALM/Wt, or divided by body mass index, ALM/BMI) was negatively associated with metabolic syndrome (MetS). Conversely, previous cross-sectional studies have indicated that the absolute ALM or ALM divided by squared height (ALM/Ht2) were positively associated with MetS. The aim of this longitudinal study was to investigate the association between low absolute or relative skeletal muscle mass, leg muscle power, or percent body fat and the development of MetS in Japanese women in a 7-y prospective study. The study participants included 346 Japanese women aged 26 to 85 years. The participants were divided into low and high groups based on the median values of ALM/Wt, ALM/BMI, ALM/Ht2, absolute ALM, or leg power. The longitudinal relationship between ALM indices or leg power and MetS development was examined using Kaplan-Meier curves and Cox regression models (average follow-up duration 7 years, range 1 to 10 years). During follow-up, 24 participants developed MetS. MetS incidence was higher in the low ALM/Wt group than the high ALM/Wt group even after controlling for age, obesity, waist circumference, family history of diabetes, smoking, and physical activity [adjusted hazard ratio = 5.60 (95% CI; 1.04-30.0)]. In contrast, MetS incidence was lower in the low ALM/Ht2 group than the high ALM/Ht2 group [adjusted hazard ratio = 10.6 (95%CI; 1.27-89.1)]. MetS incidence was not significantly different between the low and high ALM/BMI, absolute ALM, and leg power groups. Both ALM/Ht2 and ALM/Wt were not significant predictive variables for MetS development when fat mass or percent body fat was taken into account in the Cox model. At the very least, the results of this study underscore the importance of body composition measurements in that percent body fat, but not ALM, is associated with MetS development.
四肢細胞外・細胞内水分比と死亡リスクの関連 J-MICC study SAGA

岩坂知治, 山田陽介, 西田裕一郎, 原めぐみ, 安方惇, 三好伸幸, 島ノ江千里, 南里妃名子, 古川拓馬, 古賀佳代子, 檜垣靖樹, 田中恵太郎

Journal of Epidemiology　32　(Suppl.1)　101-101　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
Symposium2-7

Japanese Journal of Physical Fitness and Sports Medicine　71　(1)　20-20　2022
Publisher: The Japanese Society of Physical Fitness and Sports Medicine
DOI： 10.7600/jspfsm.71.20 　

ISSN： 0039-906X
Reply to the comments on "Association between habitual coffee consumption and skeletal muscle mass in middle-aged and older Japanese people".

Chiharu Iwasaka, Yosuke Yamada, Yuichiro Nishida, Megumi Hara, Jun Yasukata, Nobuyuki Miyoshi, Chisato Shimanoe, Hinako Nanri, Takuma Furukawa, Kayoko Koga, Mikako Horita, Yasuki Higaki, Keitaro Tanaka

Geriatrics & gerontology international　22　(1)　89-91　2022/01

DOI： 10.1111/ggi.14305 　
Correction to: Estimating thigh skeletal muscle volume using multi-frequency segmental-bioelectrical impedance analysis. International-journal

Masashi Taniguchi, Yosuke Yamada, Masahide Yagi, Ryusuke Nakai, Hiroshige Tateuchi, Noriaki Ichihashi

Journal of physiological anthropology　40　(1)　23-23　2021/12/13

DOI： 10.1186/s40101-021-00270-0 　
多周波生体電気インピーダンス法による大腿筋量および大腿四頭筋量の推定モデルの確立

谷口匡史, 山田陽介, 八木優英, 中井隆介, 建内宏重, 市橋則明

理学療法学　48　(Suppl.1)　[1G25-02]　2021/12
Publisher: (一社)日本理学療法学会連合
ISSN： 0289-3770

eISSN： 2189-602X
運動器機能低下の予防・改善を目的とした実践的運動療法の開発筋発揮張力維持スロー法を応用したリハビリテーションプログラム

森原徹, 渡邊裕也, 来田宣幸, 甲斐義浩, 山田陽介, 松井知之, 瀬尾和弥, 東善一, 平本真知子

運動器リハビリテーション　32　(4)　438-438　2021/12
Publisher: 日本運動器科学会
ISSN： 2187-8420
Association between Water and Energy Requirements with Physical Activity and Fat-Free Mass in Preschool Children in Japan. International-journal

Yosuke Yamada, Hiroyuki Sagayama, Jun Yasukata, Akiko Uchizawa, Aya Itoi, Tsukasa Yoshida, Daiki Watanabe, Yukako Hashii-Arishima, Hisashi Mitsuishi, Makoto Nishimura, Misaka Kimura, Yoshiko Aoki

Nutrients　13　(11)　2021/11/21

DOI： 10.3390/nu13114169 　

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Water and energy are essential for the human body. The doubly labeled water (DLW) method measures water turnover (WT) and total energy expenditure (TEE), which serves as a benchmark for the adequate intake (AI) of water and estimated energy requirements (EER). The objective of the current study was to examine the association of WT and TEE with physical activity and body composition in Japanese preschool children. We included 41 preschool children (22 girls, 19 boys) aged 3-6 in this study. WT, TEE, and fat-free mass (FFM) were obtained using DLW. Physical activity was measured using a triaxial accelerometer and categorized as light (LPA; 1.5-2.9 Metabolic equivalents, METs) and of moderate-to-vigorous intensity (MVPA; ≥3.0 METs). Exercise duration (Ex) was defined as ≥4.0 METs of physical activity. WT and TEE moderately positively correlated with Ex, but not with LPA. WT moderately positively correlated with BW and FFM while TEE strongly. We established predictive equations for WT and TEE using body weight (BW), FFM, step count, and Ex to guide the AI of water and EER in Japanese preschool children. We found that FFM and step count are the determinants of TEE, and that BW and Ex are the determinants of WT in preschool children.
The Association between Habitual Green Tea Consumption and Comprehensive Frailty as Assessed by Kihon Checklist Indexes among an Older Japanese Population. International-journal

Hinako Nanri, Tsukasa Yoshida, Yuya Watanabe, Hiroyuki Fujita, Misaka Kimura, Yosuke Yamada, On Behalf Of The Kameoka Study Group

Nutrients　13　(11)　2021/11/19

DOI： 10.3390/nu13114149 　

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BACKGROUND: It is unclear whether habitual green tea consumption is related to comprehensive frailty. OBJECTIVES: We conducted this study to investigate this relationship among an elderly Japanese population. METHODS: This was a cross-sectional study of baseline data from 2012. The study included 5668 Japanese participants (2766 men and 2902 women aged 65 years or older). The subjects completed a validated self-administered food frequency questionnaire that included questions on their green tea consumption. We evaluated comprehensive frailty using a 25-item Kihon Checklist (KCL), which comprised seven domains (instrumental activities of daily living (IADL), physical function, malnutrition, oral or eating function, socialization and housebound, cognitive function, and depression). Frailty was defined as a KCL score greater than or equal to seven. RESULTS: We found that a higher consumption of green tea was associated with a lower prevalence of comprehensive frailty in both sexes. Further age-stratified analysis showed that a higher consumption of green tea among women was associated with a lower prevalence of comprehensive frailty, regardless of age. In men, however, this association was found only in the older age groups. An analysis of the association between green tea consumption and the frailty subdomains showed that green tea consumption was associated with a lower prevalence of oral dysfunction and cognitive problems in both sexes. In addition, only in women was higher green tea consumption found to be associated with a lower prevalence of IADL and mobility-related disability problems. CONCLUSIONS: Green tea consumption is inversely associated with the prevalence of comprehensive frailty in Japanese men and women. Longitudinal studies are required to confirm this association.
BMI階層別にみたフレイルの該当割合中年者と高齢者の比較

疋田愛里香, 渡邉大輝, 吉田司, 中潟崇, 山田陽介, 澤田奈緒美, 岡林恵, 島田秀和, 西信雄, 宮地元彦

日本公衆衛生学会総会抄録集　80回　420-420　2021/11
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
中高齢者における指輪っかテストでスクリーニングされたサルコペニアに関連する要因

渡邉大輝, 吉田司, 中潟崇, 澤田奈緒美, 山田陽介, 黒谷佳代, 岡林恵, 島田秀和, 瀧本秀美, 西信雄, 阿部圭一, 宮地元彦

日本公衆衛生学会総会抄録集　80回　421-421　2021/11
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
指輪っかテストと基本チェックリストとの関連性中高齢者を対象とした調査

谷出敦子, 吉田司, 渡邉大輝, 中潟崇, 山田陽介, 澤田奈緒美, 岡林恵, 島田秀和, 西信雄, 宮地元彦

日本公衆衛生学会総会抄録集　80回　421-421　2021/11
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
地域在住高齢者における下肢骨格筋の量的、質的指標と咀嚼機能の関連

渡邊裕也, 渡邉大輝, 吉田司, 山田陽介, 横山慶一, 山縣恵美, 木村みさか

日本サルコペニア・フレイル学会雑誌　5　(Suppl.)　224-224　2021/10
Publisher: (一社)日本サルコペニア・フレイル学会
ISSN： 2433-1805
サルコペニアの筋量評価においては機種間の差異を考慮する必要がある

山田陽介, 山田実, 吉田司, 宮地元彦, 荒井秀典

日本サルコペニア・フレイル学会雑誌　5　(Suppl.)　205-205　2021/10
Publisher: (一社)日本サルコペニア・フレイル学会
ISSN： 2433-1805
Estimating thigh skeletal muscle volume using multi-frequency segmental-bioelectrical impedance analysis. International-journal

Masashi Taniguchi, Yosuke Yamada, Masahide Yagi, Ryusuke Nakai, Hiroshige Tateuchi, Noriaki Ichihashi

Journal of physiological anthropology　40　(1)　13-13　2021/09/30

DOI： 10.1186/s40101-021-00263-z 　

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BACKGROUND: The primary aim of this study was to investigate whether using the extracellular water/intracellular water (ECW/ICW) index and phase angle combined with segmental-bioimpedance analysis (BIA) improved the model fitting of skeletal muscle volume (SMV) estimation. The secondary aim was to compare the accuracy of segmental-BIA with that of ultrasound for estimating the quadriceps SMV measured with MRI. METHODS: Seventeen young men (mean age, 23.8 ± 3.3 years) participated in the study. The T-1 weighted images of thigh muscles were obtained using a 1.5 T magnetic resonance imaging (MRI) scanner. Thigh and quadriceps SMVs were calculated as the sum of the products of anatomical cross-sectional area and slice thickness of 6 mm across all slices. Segmental-BIA was applied to the thigh region, and data on the 50-kHz bioelectrical impedance (BI) index, ICW index, ECW/ICW index, and phase angle were obtained. The muscle thickness index was calculated as the product of the mid-thigh muscle thickness, determined using ultrasound, and thigh length. The standard error of estimate (SEE) of the regression equation was calculated to determine the model fitting of SMV estimation and converted to %SEE by dividing the SEE values by the mean SMV. RESULTS: Multiple regression analysis indicated that the combination of 50-kHz BI and the ECW/ICW index or phase angle was a significant predictor when estimating thigh SMV (SEE = 7.9 and 8.1%, respectively), but were lower than the simple linear regression (SEE = 9.4%). The ICW index alone improved the model fitting for the estimation equation (SEE = 7.6%). The model fitting of the quadriceps SMV with the 50-kHz BI or ICW index was similar to that with the skeletal muscle thickness index measured using ultrasound (SEE = 10.8, 9.6 and 9.7%, respectively). CONCLUSIONS: Combining the traditionally used 50-kHz BI index with the ECW/ICW index and phase angle can improve the model fitting of estimated SMV measured with MRI. We also showed that the model suitability of SMV estimation using segmental-BIA was equivalent to that on using ultrasound. These data indicate that segmental-BIA may be a useful and cost-effective alternative to the gold standard MRI for estimating SMV.
Physical activity and fat-free mass during growth and in later life

Klaas R Westerterp, Yosuke Yamada, Hiroyuki Sagayama, Philip N Ainslie, Lene F Andersen, Liam J Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E Blaak, Stephane Blanc, Alberto G Bonomi, Carlijn V C Bouten, Pascal Bovet, Maciej S Buchowski, Nancy F Butte, Stefan G J A Camps, Graeme L Close, Jamie A Cooper, Sai K Das, Richard Cooper, Lara R Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W Fudge, Annelies H Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marije B Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M Joosen, Peter Katzmarzyk, Kitty P Kempen, Misaka Kimura, William E Kraus, Robert F Kushner, Estelle V Lambert, William R Leonard, Nader Lessan, Corby K Martin, Anine C Medin, Erwin P Meijer, James C Morehen, James P Morton, Marian L Neuhouser, Theresa A Nicklas, Robert M Ojiambo, Kirsi H Pietiläinen, Yannis P Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L Prentice, Roberto A Rabinovich, Susan B Racette, David A Raichlen, Eric Ravussin, Rebecca M Reynolds, Susan B Roberts, Albertine J Schuit, Anders M Sjödin, Eric Stice, Samuel S Urlacher, Giulio Valenti, Ludo M Van Etten, Edgar A Van Mil, Jonathan C K Wells, George Wilson, Brian M Wood, Jack Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J Murphy-Alford, Cornelia U Loechl, Amy H Luke, Herman Pontzer, Jennifer Rood, Dale A Schoeller, William W Wong, John R Speakman, Stefan Branth, Lisa H Colbert, Niels C De Bruin, Alice E Dutman, Sölve Elmståhl, Mikael Fogelholm, Tamara Harris, Rik Heijligenberg, Hans U Jorgensen, Christel L Larsson, Elisabet M Rothenberg, Margaret McCloskey, Gerwin A Meijer, Daphne L Pannemans, Sabine Schulz, Rita Van den Berg-Emons, Wim G Van Gemert, W Wilhelmine, Venne Verboeket-van de, Jeanine A Verbunt, Renaat M Philippaerts, Amy Subar, Minna Tanskanen, Ricardo Uauy, Erica J Velthuis-te Wierik

The American Journal of Clinical Nutrition　114　(5)　1583-1589　2021/09/03
Publisher: Oxford University Press (OUP)
DOI： 10.1093/ajcn/nqab260 　

ISSN： 0002-9165

eISSN： 1938-3207

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<title>ABSTRACT</title> <sec> <title>Background</title> Physical activity may be a way to increase and maintain fat-free mass (FFM) in later life, similar to the prevention of fractures by increasing peak bone mass. </sec> <sec> <title>Objectives</title> A study is presented of the association between FFM and physical activity in relation to age. </sec> <sec> <title>Methods</title> In a cross-sectional study, FFM was analyzed in relation to physical activity in a large participant group as compiled in the International Atomic Energy Agency Doubly Labeled Water database. The database included 2000 participants, age 3–96 y, with measurements of total energy expenditure (TEE) and resting energy expenditure (REE) to allow calculation of physical activity level (PAL = TEE/REE), and calculation of FFM from isotope dilution. </sec> <sec> <title>Results</title> PAL was a main determinant of body composition at all ages. Models with age, fat mass (FM), and PAL explained 76% and 85% of the variation in FFM in females and males &lt; 18 y old, and 32% and 47% of the variation in FFM in females and males ≥ 18 y old, respectively. In participants &lt; 18 y old, mean FM-adjusted FFM was 1.7 kg (95% CI: 0.1, 3.2 kg) and 3.4 kg (95% CI: 1.0, 5.6 kg) higher in a very active participant with PAL = 2.0 than in a sedentary participant with PAL = 1.5, for females and males, respectively. At age 18 y, height and FM–adjusted FFM was 3.6 kg (95% CI: 2.8, 4.4 kg) and 4.4 kg (95% CI: 3.2, 5.7 kg) higher, and at age 80 y 0.7 kg (95% CI: −0.2, 1.7 kg) and 1.0 kg (95% CI: −0.1, 2.1 kg) higher, in a participant with PAL = 2.0 than in a participant with PAL = 1.5, for females and males, respectively. </sec> <sec> <title>Conclusions</title> If these associations are causal, they suggest physical activity is a major determinant of body composition as reflected in peak FFM, and that a physically active lifestyle can only partly protect against loss of FFM in aging adults. </sec>
Doubly labelled water–calibration approach attenuates the underestimation of energy intake calculated from self-reported dietary assessment data in Japanese older adults

Daiki Watanabe, Tsukasa Yoshida, Eiichi Yoshimura, Hinako Nanri, Chiho Goto, Kazuko Ishikawa-Takata, Naoyuki Ebine, Hiroyuki Fujita, Misaka Kimura, Yosuke Yamada

Public Health Nutrition　25　(7)　1-29　2021/09/02
Publisher: Cambridge University Press (CUP)
DOI： 10.1017/s1368980021003785 　

ISSN： 1368-9800

eISSN： 1475-2727

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<title>Abstract</title> <sec id="S1368980021003785_as1"> <title>Objective:</title> Self-reported energy intake (EI) estimation may incur systematic errors that could be attenuated through biomarker calibration. We aimed to confirm whether calibrated EI was comparable to total energy expenditure (TEE) measured using the doubly labelled water (DLW) technique. </sec> <sec id="S1368980021003785_as2"> <title>Design:</title> Cross-sectional study. </sec> <sec id="S1368980021003785_as3"> <title>Setting:</title> General older population from the Kyoto–Kameoka Study, Japan. </sec> <sec id="S1368980021003785_as4"> <title>Participants:</title> This study included sub- and main cohorts of 72 and 8,058 participants aged ≥65 years, respectively. EI was evaluated using a validated FFQ, and calibrated EI was obtained using a previously developed equation based on the DLW method. TEE was considered representative of true EI and also measured using the DLW method. We used a Wilcoxon signed-rank test and correlation analysis to compare the uncalibrated and calibrated EI with TEE. </sec> <sec id="S1368980021003785_as5"> <title>Results:</title> In the sub-cohort, the median TEE, uncalibrated EI, and calibrated EI were 8,559 kJ, 7,088 kJ, and 9,269 kJ, respectively. The uncalibrated EI was significantly lower than the TEE (median difference = −1,847 kJ; interquartile range [IQR]: −2,785 to −1,096), although the calibrated EI was not (median difference = 463 kJ; IQR: −330 to 1,541). The uncalibrated (<italic>r</italic> = 0.275) and calibrated EI (<italic>r</italic> = 0.517) significantly correlated with TEE. The reproducibility was higher for calibrated EI (interclass correlation coefficient [ICC] = 0.982) than for uncalibrated EI (ICC = 0.637). Similar findings were observed when stratifying the sample by sex. For medians, uncalibrated EI was lower (˜17%) than calibrated EI in the main cohort. </sec> <sec id="S1368980021003785_as6"> <title>Conclusions:</title> Biomarker calibration may improve the accuracy of self-reported dietary intake estimation. </sec>
Adherence to the food-based Japanese dietary guidelines and prevalence of poor oral health-related quality of life among older Japanese adults in the Kyoto–Kameoka study

Daiki Watanabe, Kayo Kurotani, Tsukasa Yoshida, Hinako Nanri, Yuya Watanabe, Heiwa Date, Aya Itoi, Chiho Goto, Kazuko Ishikawa-Takata, Takeshi Kikutani, Mitsuyoshi Yoshida, Hiroyuki Fujita, Yosuke Yamada, Misaka Kimura

British Journal of Nutrition　128　(3)　1-36　2021/08/27
Publisher: Cambridge University Press (CUP)
DOI： 10.1017/s0007114521003329 　

ISSN： 0007-1145

eISSN： 1475-2662

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<title>Abstract</title> Although better diet quality is inversely related to the risk of geriatric disorders, the association of adherence to dietary guidelines with oral health-related quality of life (OHRQoL) is unclear. We aimed to investigate this association in older Japanese adults. This cross-sectional study included 7,984 Japanese participants aged ≥65 years from the population-based Kyoto–Kameoka study. Dietary intake was estimated using a validated self-administered food frequency questionnaire. The scores for adherence to the Japanese Food Guide Spinning Top (range: 0 [worst] to 80 [best]) were calculated. These scores were stratiﬁed into quartiles (Qs). Poor OHRQoL was defined as a score ≤ 50 using a 12-item Geriatric Oral Health Assessment Index. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable logistic regression and the spline model. Higher adherence score was associated with a lower prevalence of poor OHRQoL (Q1–Q4: 36.0%, 32.1%, 27.9%, and 25.1%, respectively). An inverse association was found between the score for adherence to the food-based Japanese dietary guidelines and the ORs of poor OHRQoL among all the participants (Q1: reference; Q2: OR, 0.87 [95% CI: 0.75–1.00]; Q3: OR, 0.77 [95% CI: 0.66–0.90]; Q4: OR, 0.72 [95% CI: 0.62–0.85]; <italic>p</italic> for trend < 0.001). These relationships were similar to the results in the spline model. Higher adherence to the food-based Japanese dietary guidelines is inversely associated with the prevalence of poor OHRQoL in older adults. Our results may provide useful insights to improve and maintain oral health.
Characteristics of the Passive Muscle Stiffness of the Vastus Lateralis: A Feasibility Study to Assess Muscle Fibrosis

Akifumi Maeda, Maito Yamagishi, Yuta Otsuka, Takayuki Izumo, Tomohiro Rogi, Hiroshi Shibata, Masahiro Fukuda, Takuma Arimitsu, Yosuke Yamada, Naokazu Miyamoto, Takeshi Hashimoto

International Journal of Environmental Research and Public Health　18　(17)　8947-8947　2021/08/25
Publisher: {MDPI} {AG}
DOI： 10.3390/ijerph18178947 　
Association between habitual coffee consumption and skeletal muscle mass in middle-aged and older Japanese people.

Chiharu Iwasaka, Yosuke Yamada, Yuichiro Nishida, Megumi Hara, Jun Yasukata, Nobuyuki Miyoshi, Chisato Shimanoe, Hinako Nanri, Takuma Furukawa, Kayoko Koga, Mikako Horita, Yasuki Higaki, Keitaro Tanaka

Geriatrics & gerontology international　21　(10)　950-958　2021/08/17

DOI： 10.1111/ggi.14264 　

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AIMS: Coffee consumption has been suggested, in animal studies, to inhibit the progression of sarcopenia, possibly through its anti-inflammatory effects; however, few studies have been carried out in humans. We aimed to examine whether coffee consumption was related to indicators of sarcopenia in a Japanese population, and whether the association was mediated by reduced inflammation. METHODS: This study was a cross-sectional design. Participants were community residents (n = 6369) aged 45-74 years. We measured skeletal muscle mass index (SMI; kg/m2 ) by a bioelectrical impedance method, and grip strength with a Smedley-type dynamometer. Habitual coffee consumption was assessed by a self-administered questionnaire. Serum high-sensitivity C-reactive protein was measured as an inflammatory marker. The association between habitual coffee consumption and SMI or grip strength was analyzed with a linear regression model adjusted for covariates. RESULTS: A significant positive association was found between coffee consumption and SMI (men: β = 0.023; Ptrend = 0.004, women: β = 0.011; Ptrend = 0.012). Further adjustment for high-sensitivity C-reactive protein did not materially alter the results (men: β = 0.023; Ptrend = 0.005, women: β = 0.009; Ptrend = 0.024). The relationship between coffee consumption and grip strength did not reach statistical significance; however, a positive trend was observed (men: β = 0.208; Ptrend = 0.085, women: β = 0.092; Ptrend = 0.167). CONCLUSIONS: We found that coffee consumption was positively associated with SMI independently of inflammation in middle-aged and older Japanese people. Reduced inflammation by coffee does not seem to be an important mediator, and further investigations are required to explore the mechanisms of this association. Geriatr Gerontol Int 2021; ••: ••-••.
Daily energy expenditure through the human life course. International-journal

Herman Pontzer, Yosuke Yamada, Hiroyuki Sagayama, Philip N Ainslie, Lene F Andersen, Liam J Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E Blaak, Stephane Blanc, Alberto G Bonomi, Carlijn V C Bouten, Pascal Bovet, Maciej S Buchowski, Nancy F Butte, Stefan G Camps, Graeme L Close, Jamie A Cooper, Richard Cooper, Sai Krupa Das, Lara R Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W Fudge, Annelies H Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marjije B Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M Joosen, Peter Katzmarzyk, Kitty P Kempen, Misaka Kimura, William E Kraus, Robert F Kushner, Estelle V Lambert, William R Leonard, Nader Lessan, Corby Martin, Anine C Medin, Erwin P Meijer, James C Morehen, James P Morton, Marian L Neuhouser, Teresa A Nicklas, Robert M Ojiambo, Kirsi H Pietiläinen, Yannis P Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L Prentice, Roberto A Rabinovich, Susan B Racette, David A Raichlen, Eric Ravussin, Rebecca M Reynolds, Susan B Roberts, Albertine J Schuit, Anders M Sjödin, Eric Stice, Samuel S Urlacher, Giulio Valenti, Ludo M Van Etten, Edgar A Van Mil, Jonathan C K Wells, George Wilson, Brian M Wood, Jack Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J Murphy-Alford, Cornelia Loechl, Amy H Luke, Jennifer Rood, Dale A Schoeller, Klaas R Westerterp, William W Wong, John R Speakman

Science (New York, N.Y.)　373　(6556)　808-812　2021/08/13

DOI： 10.1126/science.abe5017 　

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Total daily energy expenditure ("total expenditure") reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.
大阪府摂津市および阪南市における働く世代からのフレイル該当割合ならびにその関連要因

吉田司, 渡邉大輝, 中潟崇, 山田陽介, 黒谷佳代, 澤田奈緒美, 田中健司, 岡林恵, 島田秀和, 瀧本秀美, 西信雄, 宮地元彦, 阿部圭一

日本公衆衛生雑誌　68　(8)　525-537　2021/08
Publisher: 日本公衆衛生学会
ISSN： 0546-1766

eISSN： 2187-8986
Energy compensation and adiposity in humans

Vincent Careau, Lewis G. Halsey, Herman Pontzer, Philip N. Ainslie, Lene F. Andersen, Liam J. Anderson, Lenore Arab, Issad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V.C. Bouten, Maciej S. Buchowski, Nancy F. Butte, Stefan G.J.A. Camps, Graeme L. Close, Jamie A. Cooper, Sai Krupa Das, Richard Cooper, Lara R. Dugas, Simon D. Eaton, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marije B. Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M. Joosen, Peter Katzmarzyk, Kitty P. Kempen, Misaka Kimura, William E. Kraus, Robert F. Kushner, Estelle V. Lambert, William R. Leonard, Nader Lessan, Corby K. Martin, Anine C. Medin, Erwin P. Meijer, James C. Morehen, James P. Morton, Marian L. Neuhouser, Theresa A. Nicklas, Robert M. Ojiambo, Kirsi H. Pietiläinen, Yannis P. Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L. Prentice, Roberto A. Rabinovich, Susan B. Racette, David A. Raichlen, Eric Ravussin, John J. Reilly, Rebecca M. Reynolds, Susan B. Roberts, Albertine J. Schuit, Anders M. Sjödin, Eric Stice, Samuel S. Urlacher, Giulio Valenti, Ludo M. Van Etten, Edgar A. Van Mil, Jonathan C.K. Wells, George Wilson, Brian M. Wood, Jack Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J. Murphy-Alford, Cornelia U. Loechl, Amy H. Luke, Jennifer Rood, Hiroyuki Sagayama, Dale A. Schoeller, William W. Wong, Yosuke Yamada, John R. Speakman

Current Biology　31　(20)　4659-4666.e2　2021/08
Publisher: Elsevier BV
DOI： 10.1016/j.cub.2021.08.016 　

ISSN： 0960-9822
Evaluation of energy intake by brief-type self-administered diet history questionnaire among male patients with stable/at risk for chronic obstructive pulmonary disease. International-journal

Yuki Nishida, Hidetoshi Nakamura, Satoshi Sasaki, Toru Shirahata, Hideaki Sato, Sanehiro Yogi, Yosuke Yamada, Satoshi Nakae, Shigeho Tanaka, Fuminori Katsukawa

BMJ open respiratory research　8　(1)　2021/08

DOI： 10.1136/bmjresp-2020-000807 　

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BACKGROUND AND OBJECTIVE: Weight loss and reduced fat-free mass are independent risk factors for mortality among patients with chronic obstructive pulmonary disease (COPD). These factors are important for determining diet therapy and examining the validity of assessment for energy intake (EI). We assessed the agreement of EI between a brief-type self-administered diet history questionnaire (BDHQ) and the doubly labelled water (DLW) method among male patients with stable/at risk for COPD. METHOD: In this cross-sectional observational study, data for 33 male patients were analysed. At the first visit, EI was estimated using a BDHQ (EIBDHQ). Total energy expenditure (TEE) was measured during 13-15 days by the DLW method, while corrected EI was calculated using the TEE and weight change during the DLW period (EIDLW). The difference between EIBDHQ and EIDLW was evaluated by the Bland-Altman method. Multiple regression analysis was used to determine the proportion of variance in the difference between EIBDHQ and EIDLW, as determined by the patient's characteristics. RESULTS: EIBDHQ was 2100 (95% CI: 1905 to 2295) kcal/day in the total population. A fixed bias was observed between EIBDHQ and EIDLW as -186 (95% CI: -422 to 50) kcal/day, while a proportional bias was not detected by the Bland-Altman analysis. Age, weight, anxiety and interleukin 6 were responsible for 61.7% of the variance in the difference between both EIs in a multiple regression model. CONCLUSIONS: The BDHQ underestimated EI among male patients with stable/at risk for COPD, but this estimation error was within an acceptable range compared with previous studies. EIBDHQ precision might be improved by considering common COPD traits, including inflammatory condition and mental state.
Combination of DXA and BIS Predicts Jump Power Better Than Traditional Measures of Sarcopenia. International-journal

Benjamin Rush, Neil Binkley, Diane Krueger, Yosuke Yamada, Adam J Kuchnia

JBMR plus　5　(8)　e10527　2021/08

DOI： 10.1002/jbm4.10527 　

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Traditional diagnostic criteria for sarcopenia use dual-energy X-ray absorptiometry (DXA)-measured appendicular lean mass (ALM), normalized to height (ALM/ht2) or body mass index (ALM/BMI) to define low muscle mass. However, muscle function declines with aging before the loss of muscle mass is detected by ALM. This is likely due, in part, to qualitative muscle changes such as extracellular and intracellular fluid compartment shifts uncaptured by DXA. We propose combining bioimpedance spectroscopy (BIS), which estimates extracellular and intracellular compartment volume, with DXA to more accurately predict muscle function. This combination may help incorporate muscle quality, thereby improving sarcopenia diagnosis. We cross-sectionally analyzed data from 248 Black and White participants aged 25 to 75 years from the Midlife in the United States Refresher Cohort. We proposed two novel muscle measures: ALM corrected by the BIS-derived whole-body extracellular to intracellular fluid ratio (E/I) and leg lean mass (LLM) corrected by leg-specific E/I, creating (ALM/(E/I)W) and (LLM/(E/I)L), respectively. We compared the associations of traditional muscle measures, ALM/(E/I)W, and LLM/(E/I)L, with grip strength and lower limb power using jumping mechanography. LLM/(E/I)L explained jump power best at R 2 = 0.803 compared with ALM/(E/I)W (p < 0.0001) and all other measures. ALM/(E/I)W explained jump power second best (R 2 = 0.759) but not significantly better than traditional muscle measures. No muscle measure performed better than covariates when predicting handgrip strength. LLM/(E/I)L outperformed ALM/ht2 and ALM/BMI when predicting jump power. We propose LLM/(E/I)L is a powerful and clinically relevant method that accounts for muscle quality. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Validating muscle mass cutoffs of four international sarcopenia-working groups in Japanese people using DXA and BIA. International-journal

Yosuke Yamada, Minoru Yamada, Tsukasa Yoshida, Motohiko Miyachi, Hidenori Arai

Journal of cachexia, sarcopenia and muscle　12　(4)　1000-1010　2021/08

DOI： 10.1002/jcsm.12732 　

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BACKGROUND: The Asian Working Group for Sarcopenia (AWGS) 2019 recommended the use of dual-energy X-ray absorptiometry (DXA) or bioelectrical impedance analysis (BIA) to assess appendicular lean mass (ALM). AWGS, European Working Group on Sarcopenia in Older People 2 (EWGSOP2), Foundation for the National Institutes of Health Sarcopenia Project (FNIH), and International Working Group on Sarcopenia (IWGS) reported different cutoff values for sarcopenia. We aimed to validate these cutoff values in a Japanese population using DXA and two different devices of segmental multi-frequency BIA (MF-BIA). METHODS: We examined the data of Japanese individuals aged 18-86 years using the DXA (n = 756) and two 8-electrode MF-BIA devices (InBody and TANITA MC) (n = 1884). To validate these cutoff values, we used a population aged 18-40 years, and calculated the 95% confidence intervals (CIs) of [mean-2SD]. RESULTS: In DXA, the 95%CIs of [mean-2SD] for ALM/Ht2 were 5.2-5.8 and 6.6-7.3 kg/m2 in women and men, respectively. The AWGS (<5.4 in women and <7.0 in men), and IWGS (≤5.67 in women and ≤7.23 in men) cutoffs were acceptable. Regarding TANITA MC, the 95%CIs of [mean-2SD] for ALM/Ht2 were 5.6-6.0 and 6.9-7.4 kg/m2 in women and men, respectively. The AWGS (<5.7 in women and <7.0 in men), EWGSOP2 (<6.0 in women and <7.0 in men), and IWGS cutoffs were acceptable. Regarding InBody, the 95%CIs of [mean-2SD] for ALM/Ht2 were 4.8-5.2 and 6.4-6.8 kg/m2 in young women and men, respectively. All cutoff values were too high compared to those measured by InBody. InBody and TANITA MC were highly correlated (P < 0.001), but the values by InBody were significantly lower than those by TANITA MC or DXA. Using Yamada's equation for InBody raw data, the AWGS, EWGSOP2, or IWGS cutoffs were acceptable. The BMI-adjusted muscle mass cutoff values were <0.60 and <0.82 m2 in women and men, respectively. We also obtained the 20th percentile in older adult population (ALM/Ht2 , <6.2 in women and <7.5 in men for TANITA MC; <5.4 in women and <7.0 in men for InBody). CONCLUSIONS: The AWGS and IWGS cutoffs were valid for DXA, and the AWGS, IWGS, and EWGSOP2 cutoffs were valid for TANITA MC in Japanese population. Because the prevalence of sarcopenia is too low particularly in women when using those criteria, the 20th percentile might be a good alternative criteria. If the ALM original InBody values are used, the cutoffs should be <5.0 kg/m2 in women and <6.6 kg/m2 in men.
Age, Sex, and Regional Differences in the Effect of COVID-19 Pandemic on Objective Physical Activity in Japan: A 2-Year Nationwide Longitudinal Study

Yosuke Yamada, T. Yoshida, T. Nakagata, H. Nanri, M. Miyachi

The journal of nutrition, health & aging　25　(8)　1032-1033　2021/07/30
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s12603-021-1662-y 　

ISSN： 1279-7707

eISSN： 1760-4788
Association of bioelectrical phase angle with aerobic capacity, complex gait ability and total fitness score in older adults. International-journal

Yosuke Yamada, Aya Itoi, Tsukasa Yoshida, Takashi Nakagata, Keiichi Yokoyama, Hiroyuki Fujita, Misaka Kimura, Motohiko Miyachi

Experimental gerontology　150　111350-111350　2021/07/15

DOI： 10.1016/j.exger.2021.111350 　

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PURPOSE: This study aimed to examine the association between whole-body or segmental phase angle (PhA) based on bioelectrical impedance analysis (BIA) and aerobic capacity (endurance), complex gait ability, and total fitness age score (FAS). METHODS: A total of 426 community-dwelling older adults (332 women and 94 men) aged 60 to 93 years participated in this study. PhA and appendicular skeletal mass index (ASMI) were obtained by an eight-electrode standing BIA. Aerobic capacity was assessed using the shuttle stamina walk test (SSTw); complex gait ability, using the timed-up-and-go test (TUG). FAS was obtained using the previously validated multi-dimensional equations based on 7-year longitudinal data. SSTw, TUG, and FAS were compared between the low PhA (<4.4° for women and <5.2° for men) and normal PhA groups. Pearson's correlation between PhA and SSTw, TUG, and FAS was determined. Multiple linear regression analysis was conducted using SSTw, TUG, and FAS as dependent variables. Age, sex, height, body mass index (BMI), ASMI, and PhA were entered into the linear model. RESULTS: SSTw and TUG results and FAS were significantly lower in the low PhA group (P < 0.05). PhA was significantly correlated with SSTw, TUG, and FAS (P < 0.001), and leg PhA showed a stronger correlation than whole-body or arm PhA. PhA at 50 kHz had higher correlation coefficients with SSTw, TUG, or FAS compared with PhA at 5 or 250 kHz. Multiple regression analyses indicated that leg PhA at 50 kHz was a significant predictor of SSTw, TUG, and FAS, independent of age, sex, height, BMI, and ASMI. CONCLUSION: Our results indicate that leg PhA is associated with multi-dimensional physical fitness in community-dwelling older adults. PhA is a highly informative biomarker of skeletal muscle and exercise physiology in clinical settings.
Validation of skeletal muscle mass estimation equations in active young adults: A preliminary study. International-journal

Hiroyuki Sagayama, Yosuke Yamada, Yoko Tanabe, Emi Kondo, Takahiro Ohnishi, Hideyuki Takahashi

Scandinavian journal of medicine & science in sports　2021/07/06

DOI： 10.1111/sms.14017 　

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We analyzed the validity of the estimation equations for skeletal muscle mass (SMM) using mass of appendicular lean soft tissue (ALST), evaluated by dual-energy X-ray absorptiometry (DXA), in healthy young males undergoing training, and compared it with the results obtained using whole-body magnetic resonance imaging (MRI). We hypothesized that a novel variable, that is, trunk and trunk-to-appendicular ratio of lean soft tissues (trunk/ALST), would be useful in reducing estimation errors in athletes or physically active participants. We analyzed the data of 30 participants (mean age 19.9 ± 1.8 years). SMM was measured using whole-body MRI, while mass of trunk and ALST was assessed using DXA. Three previously utilized estimation equations were retrieved from the literature and used for comparison. The estimated SMM values using previous equations highly correlated with measured SMM, which was determined by MRI, but the mean estimated SMM values were significantly lower than the measured-SMM values. Stepwise regression analysis revealed that mass of ALST, trunk/ALST ratio, and percent body fat were significant predictors of SMM and were incorporated as the new suggested variables. This equation accounted for 90.3% of the variance in SMM. While the previous equations' estimated SMM correlated with measured-SMM in participants with trunk/ALST ratios ≤1.05, they underestimated SMMs in those with trunk/ALST ratios >1.05. The present study confirms that the previously used equations underestimate the actual SMM, particularly in participants with high trunk/ALST ratios (>1.05). The current equation may be used in healthy and active young males, including athletes, as a preliminary tool.
Cut-off Values for Lower Limb Muscle Thickness to Detect Low Muscle Mass for Sarcopenia in Older Adults

Yoshihiro Fukumoto, Tome Ikezoe, Masashi Taniguchi, Yosuke Yamada, Shinichiro Sawano, Seigo Minani, Tsuyoshi Asai, Misaka Kimura, Noriaki Ichihashi

Clinical Interventions in Aging　Volume 16　1215-1222　2021/06
Publisher: Informa UK Limited
DOI： 10.2147/cia.s304972 　

eISSN： 1178-1998
Enhanced echo intensity and a higher extracellular water-to-intracellular water ratio are helpful clinical signs for detecting muscle degeneration in patients with knee osteoarthritis. International-journal

Masashi Taniguchi, Yoshihiro Fukumoto, Masahide Yagi, Momoko Yamagata, Masashi Kobayashi, Yosuke Yamada, Misaka Kimura, Noriaki Ichihashi

Clinical rheumatology　40　(10)　4207-4215　2021/05/17

DOI： 10.1007/s10067-021-05763-y 　

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OBJECTIVES: Enhanced muscle echo intensity (EI) with ultrasound imaging and a higher extracellular water-to-intracellular water (ECW/ICW) ratio with segmental-bioelectrical impedance spectroscopy (S-BIS) represent muscle quality loss. This study aimed to clarify quadriceps muscle degeneration characteristics, focusing on muscle quality changes in patients with knee osteoarthritis (OA). METHOD: Forty-one women with knee OA (mean age, 71.4±6.0 years) and 27 healthy women (mean age, 75.6±4.9 years) participated. Ultrasonography was used to evaluate the muscle thickness (MT) and the EI of each quadriceps compartment. The ECW/ICW ratio was obtained by S-BIS. MT, EI, and ECW/ICW ratio differences between the two groups were tested using univariate analysis of variance, adjusting for age and body mass index. Logistic regression analyses were performed with the group as the dependent variable, and the MT and EI of the vastus medialis (VM) and the ECW/ICW ratio as independent variables. RESULTS: Patients with knee OA had a significant decrease in VM MT, enhanced VM, and vastus intermedius EIs and a higher ECW/ICW ratio compared with healthy participants. Logistic regression analysis showed that the VM EI (odds ratio [OR], 1.19; 95% confidence interval [CI], 1.06-1.35) and the ECW/ICW ratio were independently associated with knee OA (OR, 1.19; 95% CI, 1.00-1.42). CONCLUSIONS: VM EI and the ECW/ICW ratio, rather than VM MT, characterised quadriceps muscle degeneration in patients with knee OA. Therefore, enhanced EI and a higher ECW/ICW ratio are helpful clinical signs for detecting muscle degeneration in patients with knee OA. Key Points •Echo intensity (EI) of the vastus medialis and the extracellular-to-intracellular water (ECW/ICW) ratio significantly increased in patients with knee osteoarthritis OA). •Enhanced EI and a higher ECW/ICW ratio are useful clinical signs for detecting muscle degeneration in patients with knee OA.
[Prevalence of frailty and its related factors in community-dwelling middle-aged and elderly adults in Settsu and Hannan cities in Osaka prefecture].

Tsukasa Yoshida, Daiki Watanabe, Takashi Nakagata, Yosuke Yamada, Kayo Kurotani, Naomi Sawada, Kenji Tanaka, Megumi Okabayashi, Hidekazu Shimada, Hidemi Takimoto, Nobuo Nishi, Motohiko Miyachi, Keiichi Abe

[Nihon koshu eisei zasshi] Japanese journal of public health　68　(8)　525-537　2021/05/14

DOI： 10.11236/jph.20-111 　

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Objectives The purpose of this study was to examine the prevalence of frailty and its associated factors in community-dwelling middle-aged and elderly adults in Settsu and Hannan cities, which are located in the north and south of Osaka prefecture, respectively.Methods We conducted a mailed, self-administered, questionnaire survey of individuals aged 40 years and older in Settsu city in 2019 and Hannan city in 2020. There are 10 primary school districts in Settsu city and 8 districts in Hannan city, from each of which 1,000 people were selected according to the age and sex structures of the districts. We included 5,134 individuals from Settsu city and 3,939 individuals from Hannan city. We defined frailty using self-reported questionnaires, the Kihon Checklist (KCL), and Simple Frailty Index (SFI). Multivariate logistic regression analysis was performed for each city to examine the association of frailty with age, sex, body mass index (BMI), family structure, subjective health, economic status, subjective physical fitness, sleeping status, smoking history, alcohol use, meal frequency and awareness of the word "frailty."Results The average age (standard deviation) of participants was 62.7 (12.5) years in Settsu city and 63.4 (12.2) years in Hannan city. The prevalence of frailty by KCL was 18.7% and 17.9% for participants in their 40s, 18.2% and 14.6% for those in their 50s, 17.0% and 15.7% for those in their 60s, 25.4% and 20.8% for those in their 70s, 39.7% and 36.1% for those 80 years and older from Settsu and Hannan cities, respectively. Using SFI, the prevalence of frailty was 16.2% and 13.5% for participants in their 40s, 15.0% and 11.9% for those in their 50s, 12.5% and 10.0% for those in their 60s, 14.6% and 12.3% for those in their 70s, and 24.7% and 22.3% for those aged 80 years and older in Settsu and Hannan cities, respectively. Significant common independent variables associated with frailty as defined using the KCL and SFI in Settsu and Hannan cities were age, subjective health, economic status, subjective physical fitness, sleeping status, and awareness of the word "frailty."Conclusion This study found some participants to be frail as early as their 40s or 50s. Thus, efforts must be made to prevent frailty in working-age populations, including those aged 40 years and older. Six factors were associated with frailty. Longitudinal or interventional studies are required to examine their causal relationships and public health significance.
Factors associated with sarcopenia screened by finger-circle test among middle-aged and older adults: a population-based multisite cross-sectional survey in Japan. International-journal

Daiki Watanabe, Tsukasa Yoshida, Takashi Nakagata, Naomi Sawada, Yosuke Yamada, Kayo Kurotani, Kenji Tanaka, Megumi Okabayashi, Hidekazu Shimada, Hidemi Takimoto, Nobuo Nishi, Keiichi Abe, Motohiko Miyachi

BMC public health　21　(1)　798-798　2021/04/26

DOI： 10.1186/s12889-021-10844-3 　

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BACKGROUND: Previous epidemiological studies have demonstrated the prevalence and relationship of various factors associated with sarcopenia in older adults; however, few have examined the status of sarcopenia in middle-aged adults. In this study, we aimed to, 1) evaluate the validity of the finger-circle test, which is potentially a useful screening tool for sarcopenia, and 2) determine the prevalence and factors associated with sarcopenia in middle-aged and older adults. METHODS: We conducted face-to-face surveys of 525 adults, who were aged 40-91 years and resided in Settsu City, Osaka Prefecture, Japan to evaluate the validity of finger-circle test. The finger-circle test evaluated calf circumference by referring to an illustration printed on the survey form. The area under the receiver operating characteristic curves (AUROC) was plotted to evaluate the validity of the finger-circle test for screening sarcopenia and compared to that evaluated by skeletal muscle mass index (SMI) measured using bioimpedance. We also conducted multisite population-based cross-sectional anonymous mail surveys of 9337 adults, who were aged 40-97 years and resided in Settsu and Hannan Cities, Osaka Prefecture, Japan. Participants were selected through stratified random sampling by sex and age in the elementary school zones of their respective cities. We performed multiple logistic regression analysis to explore associations between characteristics and prevalence of sarcopenia. RESULTS: Sarcopenia, defined by SMI, was moderately predicted by a finger-circle test response showing that the subject's calf was smaller than their finger-circle (AUROC: 0.729, < 65 years; 0.653, ≥65 years); such subjects were considered to have sarcopenia. In mail surveys, prevalence of sarcopenia screened by finger-circle test was higher in older subjects (approximately 16%) than in middle-aged subjects (approximately 8-9%). In a multiple regression model, the factors associated with sarcopenia were age, body mass index, smoking status, self-reported health, and number of meals in all the participants. CONCLUSIONS: Sarcopenia, screened by the finger-circle test, was present not only among older adults but also among middle-aged adults. These results may provide useful indications for developing public health programs, not only for the prevention, but especially for the management of sarcopenia. TRIAL REGISTRATION: UMIN000036880, registered prospectively May 29, 2019, https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000042027.
Energy expenditure and physical activity in COPD by doubly labelled water method and an accelerometer. International-journal

Hideaki Sato, Hidetoshi Nakamura, Yuki Nishida, Toru Shirahata, Sanehiro Yogi, Tomoe Akagami, Machika Soma, Kaiji Inoue, Mamoru Niitsu, Tomohiko Mio, Tatsuyuki Miyashita, Makoto Nagata, Satoshi Nakae, Yosuke Yamada, Shigeho Tanaka, Fuminori Katsukawa

ERJ open research　7　(2)　2021/04

DOI： 10.1183/23120541.00407-2020 　

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Although weight loss suggests poor prognosis of COPD, only a few studies have examined total energy expenditure (TEE) or physical activity level (PAL) using the doubly labelled water (DLW) method. We evaluated TEE and PAL using the DLW method together with a triaxial accelerometer to elucidate the relationships between TEE, PAL and clinical parameters leading to a practical means of monitoring COPD physical status. This study evaluated 50- to 79-year-old male patients with mild to very severe COPD (n=28) or at risk for COPD (n=8). TEE, activity energy expenditure for 2 weeks and basal metabolic rate were measured by DLW, an accelerometer and indirect calorimetry, respectively. All patients underwent pulmonary function, chest-computed tomography, 6-min walk test, body composition and grip strength tests. Relationships between indices of energy expenditure and clinical parameters were analysed. Bland-Altman analysis was used to examine the agreement of TEE and PAL between the DLW method and the accelerometer. TEE and PAL using DLW in the total population were 2273±445 kcal·day-1 and 1.80±0.20, respectively. TEE by DLW correlated well with that from the accelerometer and grip strength (p<0.0001), and PAL by DLW correlated well with that from the accelerometer (p<0.0001), grip strength and 6-min walk distance (p<0.001) among various clinical parameters. However, the accelerometer underestimated TEE (215±241 kcal·day-1) and PAL (0.18±0.16), with proportional biases in both indices. TEE and PAL can be estimated by accelerometer in patients with COPD if systematic errors and relevant clinical factors such as muscle strength and exercise capacity are accounted for.
地域在住高齢者の筋量減少を推定する筋厚カットオフ値の検討

福元喜啓, 池添冬芽, 谷口匡史, 山田陽介, 澤野翔一朗, 木村みさか, 市橋則明

理学療法学　47　(Suppl.1)　6-6　2021/03
Publisher: (一社)日本理学療法学会連合
ISSN： 0289-3770

eISSN： 2189-602X
Whole-body insulin resistance and energy expenditure indices, serum lipids, and skeletal muscle metabolome in a state of lipoprotein lipase overexpression. International-journal

Yuichiro Nishida, Kazutoshi Nishijima, Yosuke Yamada, Hiroaki Tanaka, Akiko Matsumoto, Jianglin Fan, Yoichi Uda, Hajime Tomatsu, Hiroyuki Yamamoto, Kenjiro Kami, Shuji Kitajima, Keitaro Tanaka

Metabolomics : Official journal of the Metabolomic Society　17　(3)　26-26　2021/02/16

DOI： 10.1007/s11306-021-01777-4 　

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INTRODUCTION: Overexpression of lipoprotein lipase (LPL) protects against high-fat-diet (HFD)-induced obesity and insulin resistance in transgenic rabbits; however, the molecular mechanisms remain unclear. Skeletal muscle is a major organ responsible for insulin-stimulated glucose uptake and energy expenditure. OBJECTIVES: The main purpose of the current study was to examine the effects of the overexpression of LPL on the skeletal muscle metabolomic profiles to test our hypothesis that the mitochondrial oxidative metabolism would be activated in the skeletal muscle of LPL transgenic rabbits and that the higher mitochondrial oxidative metabolism activity would confer better phenotypic metabolic outcomes. METHODS: Under a HFD, insulin resistance index was measured using the intravenous glucose tolerance test, and total energy expenditure (TEE) was measured by doubly-labeled water in control and LPL transgenic rabbits (n = 12, each group). Serum lipids, such as triglycerides and free fatty acid, were also measured. The skeletal muscle metabolite profile was analyzed using capillary electrophoresis time-of flight mass spectrometry in the two groups (n = 9, each group). A metabolite set enrichment analysis (MSEA) with muscle metabolites and a false discovery rate q < 0.2 was performed to identify significantly different metabolic pathways between the 2 groups. RESULTS: The triglycerides and free fatty acid levels and insulin resistance index were lower, whereas the TEE was higher in the LPL transgenic rabbits than in the control rabbits. Among 165 metabolites detected, the levels of 37 muscle metabolites were significantly different between the 2 groups after false discovery rate correction (q < 0.2). The MSEA revealed that the TCA cycle and proteinogenic amino acid metabolism pathways were significantly different between the 2 groups (P < 0.05). In the MSEA, all four selected metabolites for the TCA cycle (2-oxoglutaric acid, citric acid, malic acid, fumaric acid), as well as eight selected metabolites for proteinogenic amino acid metabolism (asparagine, proline, methionine, phenylalanine, histidine, arginine, leucine, isoleucine) were consistently increased in the transgenic rabbits compared with control rabbits, suggesting that these two metabolic pathways were activated in the transgenic rabbits. Some of the selected metabolites, such as citric acid and methionine, were significantly associated with serum lipids and insulin resistance (P < 0.05). CONCLUSION: The current results suggest that the overexpression of LPL may lead to increased activities of TCA cycle and proteinogenic amino acid metabolism pathways in the skeletal muscle, and these enhancements may play an important role in the biological mechanisms underlying the anti-obesity/anti-diabetes features of LPL overexpression.
A standard calculation methodology for human doubly labeled water studies. International-journal

John R Speakman, Yosuke Yamada, Hiroyuki Sagayama, Elena S F Berman, Philip N Ainslie, Lene F Andersen, Liam J Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E Blaak, Stephane Blanc, Alberto G Bonomi, Carlijn V C Bouten, Pascal Bovet, Maciej S Buchowski, Nancy F Butte, Stefan G J A Camps, Graeme L Close, Jamie A Cooper, Seth A Creasy, Sai Krupa Das, Richard Cooper, Lara R Dugas, Cara B Ebbeling, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W Fudge, Annelies H Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marije B Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M Joosen, Peter Katzmarzyk, Kitty P Kempen, Misaka Kimura, William E Kraus, Robert F Kushner, Estelle V Lambert, William R Leonard, Nader Lessan, David S Ludwig, Corby K Martin, Anine C Medin, Erwin P Meijer, James C Morehen, James P Morton, Marian L Neuhouser, Theresa A Nicklas, Robert M Ojiambo, Kirsi H Pietiläinen, Yannis P Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L Prentice, Roberto A Rabinovich, Susan B Racette, David A Raichlen, Eric Ravussin, Rebecca M Reynolds, Susan B Roberts, Albertine J Schuit, Anders M Sjödin, Eric Stice, Samuel S Urlacher, Giulio Valenti, Ludo M Van Etten, Edgar A Van Mil, Jonathan C K Wells, George Wilson, Brian M Wood, Jack Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J Murphy-Alford, Cornelia U Loechl, Edward L Melanson, Amy H Luke, Herman Pontzer, Jennifer Rood, Dale A Schoeller, Klaas R Westerterp, William W Wong

Cell reports. Medicine　2　(2)　100203-100203　2021/02/16

DOI： 10.1016/j.xcrm.2021.100203 　

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The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO2 over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.
サクセスフル・エイジングに向けた健康政策とそのエビデンス身体活動と栄養の科学からフレイルを考える

宮地元彦, 渡邉大輝, 吉田司, 山田陽介

健康支援　23　(1)　62-62　2021/02
Publisher: 日本健康支援学会
ISSN： 1345-0174
サクセスフル・エイジングに向けた健康政策とそのエビデンス身体活動と栄養の科学からフレイルを考える

宮地元彦, 渡邉大輝, 吉田司, 山田陽介

健康支援　23　(1)　62-62　2021/02
Publisher: 日本健康支援学会
ISSN： 1345-0174
骨格筋超音波エコー輝度とDixon法による筋内脂肪割合との関連—超音波撮像におけるフォーカス位置の違いによる検討

福元喜啓, 谷口匡史, 八木優英, 廣野哲也, 山縣桃子, 中井隆介, 山田陽介, 木村みさか, 池添冬芽, 市橋則明

理学療法学Supplement　48S1　A-193-A-193　2021
Publisher: 公益社団法人日本理学療法士協会
DOI： 10.14900/cjpt.48s1.a-193 　
習慣的コーヒー摂取と骨格筋の関連 J-MICC study SAGA

岩坂知治, 山田陽介, 西田裕一郎, 原めぐみ, 島ノ江千里, 古川拓馬, 古賀佳代子, 檜垣靖樹, 田中恵太郎

Journal of Epidemiology　31　(Suppl.)　102-102　2021/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
Comprehensive geriatric intervention in community-dwelling older adults: a cluster-randomized controlled trial:-Secondary Publication in Japanese Language of an Original English Article Published in the Journal of Cachexia, Sarcopenia and Muscle

Watanabe Yuya, Kyoto-Kameoka Study Group, Yamada Yosuke, Yoshida Tsukasa, Yokoyama Keiichi, Miyake Motoko, Yamagata Emi, Yamada Minoru, Yoshinaka Yasuko, Kimura Misaka

Research in Exercise Epidemiology　2021
Publisher: Japanese Association of Exercise Epidemiology
DOI： 10.24804/ree.2014 　

ISSN： 1347-5827

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Background: In longevity societies, one of the most serious social issues is sarcopenia and/or frailty. Preventing them is important for maintaining independence and quality of life in the older population. This study investigated the effect of a self-monitoring comprehensive geriatric intervention programme (CGIP) on physical function and muscle size in community-dwelling older adults. We compared the effects of a CGIP using weekly class-styled (CS) sessions and a home-based (HB) programme. Methods: The 526 participants were randomized into one of two groups (CS 251, HB 275) based on their residential districts. We conducted a 12 week CGIP, which consisted of low-load resistance exercise, physical activity increments, oral function improvements, and a nutritional guide. All participants were encouraged to attend two 90 min lectures that included instructions on the CGIP. They were provided with exercise materials (triaxial-accelerometers/pedometers, ankle weights, and elastic bands) and diary logs. The CS group attended 90 min weekly sessions and independently executed the programme on other days, whereas the HB group only received instructions on how to execute the programme. Physical functions, such as knee extension strength (KES), normal and maximum walking speed, the timed up-and-go test, and anterior thigh muscle thickness (MT), were measured and analysed using intention-to-treat analysis before and after the 12 week intervention. Results: Of the 526 participants identified, 517 (CS 243 age 74.0 ± 5.4 women 57.2%, HB 274 age 74.0 ± 5.6 women 58.8%) were enrolled. Nine (CS 8, HB 1) were excluded from the analysis because they did not participate in the pre-intervention measurements. Both interventions significantly improved KES (CS 18.5%, HB 10.6%), normal walking speed (CS 3.7%, HB 2.8%), and MT (CS 3.2%, HB 3.5%). Greater improvement of KES was observed in the CS group (P = 0.003). Maximum walking speed (CS 4.7%, HB 1.8%; P = 0.001) and timed up-and-go (CS -4.7%, HB -0.2%; P < 0.001) significantly improved in the CS group only. Conclusions: The intervention was effective in preventing sarcopenia and/or frailty. Most physical functions and MT improved after both interventions. The HB intervention is cost-effective and may help prevent sarcopenia and/or frailty in the large older population.
Validity of Bioimpedance Spectroscopy in the Assessment of Total Body Water and Body Composition in Wrestlers and Untrained Subjects. International-journal

Keisuke Shiose, Emi Kondo, Rie Takae, Hiroyuki Sagayama, Keiko Motonaga, Yosuke Yamada, Yoshinari Uehara, Yasuki Higaki, Hideyuki Takahashi, Hiroaki Tanaka

International journal of environmental research and public health　17　(24)　2020/12/16

DOI： 10.3390/ijerph17249433 　

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Bioimpedance spectroscopy (BIS) is an easy tool to assess hydration status and body composition. However, its validity in athletes remains controversial. We investigated the validity of BIS on total body water (TBW) and body composition estimation in Japanese wrestlers and untrained subjects. TBW of 49 young Japanese male subjects (31 untrained, 18 wrestlers) were assessed using the deuterium dilution method (DDM) and BIS. De Lorenzo's and Moissl's equations were employed in BIS for TBW estimation. To evaluate body composition, Siri's 3-compartment model and published TBW/fat-free mass (FFM) ratio were applied in DDM and BIS, respectively. In untrained subjects, DDM and BIS with de Lorenzo's equation showed consistent TBW estimates, whereas BIS with Moissl's equation overestimated TBW (p < 0.001 vs. DDM). DDM and BIS with de Lorenzo's equation estimated FFM and percent of fat mass consistently, whereas BIS with Moissl's equation over-estimated and under-estimated them (p < 0.001 vs. DDM). In wrestlers, BIS with de Lorenzo's and Moissl's equations assessed TBW similarly with DDM. However, the Bland-Altman analysis revealed a proportional bias for TBW in BIS with de Lorenzo's equation (r = 0.735, p < 0.001). Body composition assessed with BIS using both equations and DDM were not different. In conclusion, BIS with de Lorenzo's equation accurately estimates the TBW and body composition in untrained subjects, whereas BIS with Moissl's equation is more valid in wrestlers. Our results demonstrated the usefulness of BIS for assessing TBW and body composition in Japanese male wrestlers.
Seasonal Changes in Anthropometric, Physiological, Nutritional, and Performance Factors in Collegiate Rowers. International-journal

Junta Iguchi, Kenji Kuzuhara, Kanako Katai, Tatsuya Hojo, Yoshihiko Fujisawa, Misaka Kimura, Yasuyoshi Yanagida, Yosuke Yamada

Journal of strength and conditioning research　34　(11)　3225-3231　2020/11

DOI： 10.1519/JSC.0000000000002521 　

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Iguchi J, Kuzuhara, K, Katai, K, Hojo, T, Fujisawa, Y, Kimura, M, Yanagida, Y, and Yamada, Y. Seasonal changes in anthropometric, physiological, nutritional, and performance factors in collegiate rowers. J Strength Cond Res 34(11): 3225-3231, 2020-Well-controlled seasonal distribution of training intensity seems to be an important variable for endurance athletes' success as competitors and for avoidance of overtraining. The aim of this study was to examine the interrelationships of training distribution, body composition, energy intake/expenditure, and rowing ergometer performance throughout the 2012-2013 season. In this study of 15 collegiate male rowers, most of whom started rowing during their time at the university, we divided the 2012-2013 season (total 37 weeks) into 3 phases (off-season, December to mid-March, 16 weeks; pre-season, late March-April, 5 weeks; and in-season, May-August, 16 weeks) and analyzed the transition of 2,000-m rowing ergometer time, training intensity/volume, body composition (body mass and body fat), and energy intake/expenditure in each phase. There were significant main effects of the training time by the intensities; 2,000-m rowing ergometer time; energy expenditure; and protein, fat, and carbohydrate intake across the seasons (p < 0.05). Two findings were particularly important. First, on-water high-intensity training, especially for inexperienced rowers, may contribute to improvement of 2,000-m rowing ergometer performance. Second, higher intake of carbohydrate, and to a lesser degree, protein, is necessary for optimal training adaptation (e.g., increase of muscle glycogen content), and results in better 2,000-m performance on the rowing ergometer. Also, those findings may be beneficial to the coaches who are interested in designing the well-controlled seasonal training program, which is especially intended to improve the 2,000-m rowing ergometer performance as well as avoidance of overtraining.
運転不安を有する高齢運転者の身体機能の特徴福岡那珂川研究

古瀬裕次郎, 池永昌弘, 山田陽介, 武田典子, 森村和浩, 木村みさか, 清永明, 檜垣靖樹

日本老年医学会雑誌　57　(4)　475-483　2020/10
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
運転不安を有する高齢運転者の身体機能の特徴福岡那珂川研究

古瀬裕次郎, 池永昌弘, 山田陽介, 武田典子, 森村和浩, 木村みさか, 清永明, 檜垣靖樹

日本老年医学会雑誌　57　(4)　475-483　2020/10
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
Impact of obesity on underreporting of energy intake in type 2 diabetic patients: Clinical Evaluation of Energy Requirements in Patients with Diabetes Mellitus (CLEVER-DM) study. International-journal

Itsuko Miyazawa, Katsutaro Morino, Keiko Fuse, Keiko Kondo, Akiko Ohi, Kaori Nishida, Mika Kurihara, Shoko Yasuhara, Naoko Nakanishi, Yuki Nishida, Satoshi Nakae, Yosuke Yamada, Shigeho Tanaka, Naoyuki Ebine, Satoshi Sasaki, Fuminori Katsukawa, Masaya Sasaki, Satoshi Ugi, Hiroshi Maegawa

Clinical nutrition ESPEN　39　251-254　2020/10

DOI： 10.1016/j.clnesp.2020.07.001 　

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BACKGROUND & AIMS: Although accurate assessment of energy intake (EI) is critical in diabetes care, underreporting of EI on dietary records (DR) is often an issue. However, few studies have examined EI with doubly labeled water (DLW) in patients with diabetes mellitus. We aimed to investigate the impact of sex and obesity on the dissociation of DR from total energy expenditure (TEE) evaluated with DLW in patients with type 2 diabetes. METHODS: Fifty-two patients with type 2 diabetes aged 60-79 years were enrolled for the Clinical Evaluation of Energy Requirements in Patients with Diabetes Mellitus (CLEVER-DM) study at a single university hospital. TEE was measured over 14 days by the DLW method as standard. EI was calculated by assessment of 3-day DR by registered dietitians. RESULTS: The mean difference between EI and TEE was 238 ± 412 kcal/day (~10% of TEE). Neither EI nor TEE was significantly different between obese (body mass index (BMI) ≥25 kg/m2) and non-obese (BMI <25 kg/m2) patients. There was a negative correlation between EI/TEE ratio and BMI in women (R = -0.437, P = 0.033) but not in men (R = -0.174, P = 0.377). There was a significant difference in EI/TEE ratio between obese and non-obese patients among women (0.85 ± 0.15 vs. 1.01 ± 0.21, P = 0.045) but not men (0.85 ± 0.20 vs. 0.87 ± 0.17, P = 0.79). CONCLUSIONS: EI calculated by 3-day DR may underestimate habitual intake, which is assumed to be equal to TEE measured by the DLW method except in non-obese women with diabetes. CLINICAL TRIAL REGISTRATION NUMBER: UMIN000023051.
Energy Gap between Doubly Labeled Water-Based Energy Expenditure and Calculated Energy Intake from Recipes and Plate Waste, and Subsequent Weight Changes in Elderly Residents in Japanese Long-Term Care Facilities: CLEVER Study. International-journal

Yuki Nishida, Shigeho Tanaka, Satoshi Nakae, Yosuke Yamada, Hiroyuki Shirato, Hirohiko Hirano, Satoshi Sasaki, Fuminori Katsukawa

Nutrients　12　(9)　2020/09/02

DOI： 10.3390/nu12092677 　

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Unintentional weight loss is a major frailty component; thus, assessing energy imbalance is essential for institutionalized elderly residents. This study examined prediction errors of the observed energy intake (OEI) against the actual energy intake obtained from the doubly labeled water (DLW) method and clarified the relationship between the energy gap obtained by subtracting total energy expenditure (TEE) from OEI and subsequent weight changes in elderly residents in long-term care facilities. Overall, 46 participants were recruited in Japan. TEE was measured using the DLW method, and OEI was calculated from recipes and plate waste simultaneously over a 14-15-day period at baseline. The total energy intake (TEIDLW) was determined on the basis of DLW and weight changes during the DLW period. The weight was longitudinally tracked monthly for 12 months in the 28 residents who still lived at the facilities. OEI was higher than TEIDLW by a mean of 232 kcal/day (15.3%) among 46 residents at baseline. The longitudinal data of 28 residents showed that the energy gap tended to be correlated with the slope of weight change (ρ = 0.337, p = 0.080) and the median value was significantly lower in the weight loss group (152 kcal/day) than in the weight gain group (350 kcal/day) (p < 0.05). In conclusion, weight loss could occur at Japanese long-term care facilities even if the difference obtained by subtracting TEE from OEI was positive because OEI was overestimated by more than 200 kcal/day.
Association of Lower-Extremity Muscle Performance and Physical Activity Level and Intensity in Middle-Aged and Older Adults: A Doubly Labeled Water and Accelerometer Study

R. Takae, Y. Hatamoto, J. Yasukata, Y. Kose, T. Komiyama, M. Ikenaga, E. Yoshimura, Y. Yamada, N. Ebine, Yasuki Higaki, H. Tanaka

The journal of nutrition, health & aging　2020/08/04
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s12603-020-1449-6 　

ISSN： 1279-7707

eISSN： 1760-4788
糖尿病診療ガイドライン2019に基づいた食事療法を検証するCLEVER-DM研究より

宮澤伊都子, 森野勝太郎, 中川恵子, 近藤慶子, 大井彰子, 西田香, 栗原美香, 中西直子, 西田優紀, 中江悟司, 山田陽介, 田中茂穂, 海老根直之, 佐々木敏, 勝川史憲, 佐々木雅也, 卯木智, 前川聡

糖尿病　63　(Suppl.1)　S-136　2020/08
Publisher: (一社)日本糖尿病学会
ISSN： 0021-437X

eISSN： 1881-588X
糖尿病診療ガイドライン2019に基づいた食事療法を検証するCLEVER-DM研究より

宮澤伊都子, 森野勝太郎, 中川恵子, 近藤慶子, 大井彰子, 西田香, 栗原美香, 中西直子, 西田優紀, 中江悟司, 山田陽介, 田中茂穂, 海老根直之, 佐々木敏, 勝川史憲, 佐々木雅也, 卯木智, 前川聡

糖尿病　63　(Suppl.1)　S-136　2020/08
Publisher: (一社)日本糖尿病学会
ISSN： 0021-437X

eISSN： 1881-588X
Objectively Measured Daily Step Counts and Prevalence of Frailty in 3,616 Older Adults International-journal Peer-reviewed

Daiki Watanabe, Tsukasa Yoshida, Yuya Watanabe, Yosuke Yamada, Misaka Kimura, Kyoto‐Kameoka Study Group

Journal of the American Geriatrics Society　accepted　(10)　2310-2318　2020/07/07
Publisher: Wiley
DOI： 10.1111/jgs.16655 　

ISSN： 0002-8614

eISSN： 1532-5415
Association between Mixing Ability of Masticatory Functions Measured Using Color-Changing Chewing Gum and Frailty among Japanese Older Adults: The Kyoto-Kameoka Study. International-journal Peer-reviewed

Daiki Watanabe, Tsukasa Yoshida, Keiichi Yokoyama, Yasuko Yoshinaka, Yuya Watanabe, Takeshi Kikutani, Mitsuyoshi Yoshida, Yosuke Yamada, Misaka Kimura, Kyoto-Kameoka Study Group

International journal of environmental research and public health　17　(12)　2020/06/24

DOI： 10.3390/ijerph17124555 　

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The relationship between mixing ability of masticatory functions and frailty has not been well evaluated. This study investigated the prevalence of physical and comprehensive frailty and its association with mixing ability in 1106 older adults aged ≥65 years who underwent physical examination as part of the Japanese Kyoto-Kameoka Study. Mixing ability was assessed using color-changing chewing gum (1-5 points, 5 representing the best mixing ability). Participants were divided into four groups (5 points, 4 points, 3 points, and 1 or 2 points). The modified Japanese versions of the Cardiovascular Health Study (mJ-CHS) criteria and the validated Kihon Checklist (KCL) were used to assess physical and comprehensive frailty, respectively. Multivariate logistic regression was used to evaluate the association between frailty and mixing ability. The prevalence of physical and comprehensive frailty was 11.8% and 27.9%, respectively. After adjusting for confounders, the odds ratios of physical and comprehensive frailty comparing the highest to the lowest chewing gum score groups were 3.64 (95% confidence interval (CI): 1.62 to 8.18; p for trend = 0.001) and 2.09 (95% CI: 1.09 to 4.03; p for trend = 0.009), respectively. Mixing-ability tests involving chewing gum may be an indicator associated with both physical and comprehensive frailty.
Association between the prevalence of frailty and doubly labeled water-calibrated energy intake among community-dwelling older adults Peer-reviewed

Daiki Watanabe, Tsukasa Yoshida, Hinako Nanri, Yuya Watanabe, Heiwa Date, Aya Itoi, Chiho Goto, Kazuko Ishikawa-Takata, Hiroyuki Sagayama, Naoyuki Ebine, Hisamine Kobayashi, Misaka Kimura, Yosuke Yamada

The Journals of Gerontology: Series A　2020/06/03
Publisher: Oxford University Press (OUP)
DOI： 10.1093/gerona/glaa133 　

ISSN： 1079-5006

eISSN： 1758-535X

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<title>Abstract</title> <sec> <title>Background</title> Appropriate energy intake (EI) is essential to prevent frailty. Because self-reported EI is inaccurate and has systematic errors, adequate biomarker calibration is required. This study examined the association between doubly labeled water (DLW)-calibrated EI and the prevalence of frailty among community-dwelling older adults. </sec> <sec> <title>Methods</title> A cross-sectional study was performed using baseline data of 7022 older adults aged ≥65 years in the Kyoto-Kameoka Study. EI was evaluated using a validated food frequency questionnaire (FFQ), and calibrated EI was obtained from a previously established equation using the DLW method. Physical and comprehensive frailty were defined by the Fried phenotype (FP) model and the Kihon Checklist (KCL), respectively. We used multivariable-adjusted restricted cubic spline logistic regression analysis. </sec> <sec> <title>Results</title> The prevalence of physical frailty was 14.8% and 13.6% in women and men, respectively. The spline models showed significant reverse J-shaped or U-shaped relationships between the prevalence of physical or comprehensive frailty against the DLW-calibrated EI, respectively. The lowest prevalence of both types of frailty was found at 1900–2000 kcal·d-1 in women and 2400–2500 kcal·d-1 in men, which corresponded to approximately 40 kcal·d-1·kg IBW-1 (ideal body weight = 22 × height2) with DLW-calibrated EI. Uncalibrated EI underestimated approximately 20% compared with calibrated EI; underestimated EI were attenuated by calibration approach. </sec> <sec> <title>Conclusions</title> This study suggests that low EI has a greater detrimental effect compared with excessive EI, particularly on physical frailty. Using biomarkers to calibrate EI holds promise for providing accurate energy requirements to establish guidelines used in public health and clinical nutrition. </sec>
A U-Shaped Relationship Between the Prevalence of Frailty and Body Mass Index in Community-Dwelling Japanese Older Adults: The Kyoto-Kameoka Study. International-journal Peer-reviewed

Daiki Watanabe, Tsukasa Yoshida, Yuya Watanabe, Yosuke Yamada, Misaka Kimura, Kyoto-Kameoka Study Group

Journal of clinical medicine　9　(5)　1367　2020/05/06

DOI： 10.3390/jcm9051367 　

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The relationship between body mass index (BMI) and frailty remains unclear. Using two validated frailty assessment tools, this study aimed to investigate the relationship between the prevalence of frailty and BMI in Japanese older adults. This cross-sectional study used baseline data of 7191 individuals aged ≥65 years, living in Kameoka City, Kyoto, Japan. The BMI was calculated based on self-reported height and body weight, and classified into six categories. Frailty was defined using two validated assessment tools, the Fried phenotype (FP) model and Kihon Checklist (KCL). We evaluated the relationship between frailty and BMI using a multivariate restricted cubic spline logistic regression. The prevalence of frailty defined using the FP model was 25.3%, 19.6%, 14.3%, 12.4%, 12.6%, and 19.4% for each BMI category of <18.5, 18.5-19.9, 20.0-22.4, 22.5-24.9, 25.0-27.4, and ≥27.5 kg/m2, respectively. The spline model showed a significant U-shaped relationship between BMI and the prevalence of frailty defined using both, KCL and FP models. This study found that the BMI range corresponding to lowest prevalence of frailty defined using both tools was 21.4-25.7 kg/m2. Thus, a healthy BMI may reduce the prevalence of frailty, and the risk of frailty needs to be evaluated in individuals who are underweight or overweight.
Estimating Energy Cost of Body Weight Resistance Exercise Using a Multistage Exercise Test. International-journal Peer-reviewed

Takashi Nakagata, Yosuke Yamada, Hisashi Naito

Journal of strength and conditioning research　36　(5)　1290-1296　2020/05/05

DOI： 10.1519/JSC.0000000000003622 　

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Nakagata, T, Yamada, Y, and Naito, H. Estimating energy cost of body weight resistance exercise using a multistage exercise test. J Strength Cond Res XX(X): 000-000, 2020-The purpose of this study was to examine energy cost of body weight resistance exercises with slow movement in young men using a multistage exercise test. Fifteen men aged 21-29 years performed 3 exercises (heel-raise, squat, and push-up) at different frequencies (1, 2, 3, 4, 5, and 6 repetitions·min). Oxygen consumption was measured using indirect calorimetry; we then computed a simple linear regression between aerobic energy expenditure (EE) and repetition frequency. The slope coefficient in the regression represents the energy cost of those exercises; we compared the extrapolated EE for a frequency of 10 repetitions·min. Gross EE increased linearly with repetition frequency in all subjects (y = ax + b). Energy cost was significantly greater in the case of the push-up than in the case of the squat {squat: 0.50 ± 0.14 (95% confidence interval [CI], 0.42-0.58); push-up: 0.77 ± 0.20 kcal (95% CI, 0.66-0.88); and the heel-raise elicited the lowest energy cost: 0.13 ± 0.04 kcal (95% CI, 0.11-0.15)}. Extrapolated EE at 10 repetitions·min was 2.7 ± 0.5 kcal (2.3 metabolic equivalents [METs]), 6.3 ± 1.4 kcal (5.4 METs), and 9.2 ± 2.1 kcal (7.8 METs), respectively, according to the regression based on aerobic EE. These results will be useful for health professionals in prescribing resistance exercise programs improving muscle fitness and considering for weight management.
Total Energy Expenditure, Body Composition, Physical Activity, and Step Count in Japanese Preschool Children: A Study Based on Doubly Labeled Water. International-journal

Yosuke Yamada, Hiroyuki Sagayama, Aya Itoi, Makoto Nishimura, Kaori Fujisawa, Yasuki Higaki, Misaka Kimura, Yoshiko Aoki

Nutrients　12　(5)　2020/04/26

DOI： 10.3390/nu12051223 　

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Adequate energy intake is essential for the healthy development of children, and the estimated energy requirement of children is determined by total daily energy expenditure (TDEE) and energy deposition for growth. A previous study in Japanese tweens indicated that TDEE could be estimated by fat-free mass (FFM) and step count. The aims of this study were to measure TDEE in Japanese preschool children and to confirm whether TDEE can be estimated by FFM and step count in preschool children. Twenty-one children aged 4-6 years old (11 girls and 10 boys; age, 5.1 (0.9) years; height, 107.2 (6.6) cm; weight, 17.5 (1.7) kg; BMI, 15.3 (1.3); mean (SD)) participated in this study. FFM and 7-day TDEE were obtained by doubly labeled water (DLW). Participants wore accelerometers during the DLW measurement period. No significant differences were observed in age-adjusted height, weight, BMI, FFM (13.0 (1.5) kg), or TDEE (1300 (174) kcal/day) between girls and boys. Girls had significantly higher percent fat and a lower daily step count than boys. Stepwise regression analysis revealed that FFM and step count were significant predictors of TDEE; TDEE (kcal/day) = 85.0 × FFM (kg) + 0.0135 × step count (steps/day). This accounted for 74% of TDEE variance. The current study confirmed that FFM and step count are major determinants of TDEE in Japanese preschool children as well as adolescents, although further research is needed to obtain precise equations.
Validity of the Use of a Triaxial Accelerometer and a Physical Activity Questionnaire for Estimating Total Energy Expenditure and Physical Activity Level among Elderly Patients with Type 2 Diabetes Mellitus: CLEVER-DM Study. International-journal Peer-reviewed

Yuki Nishida, Shigeho Tanaka, Satoshi Nakae, Yosuke Yamada, Katsutaro Morino, Keiko Kondo, Kaori Nishida, Akiko Ohi, Mika Kurihara, Masaya Sasaki, Satoshi Ugi, Hiroshi Maegawa, Naoyuki Ebine, Satoshi Sasaki, Fuminori Katsukawa

Annals of nutrition & metabolism　76　(1)　1-11　2020/03/13

DOI： 10.1159/000506223 　

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INTRODUCTION: Evaluation of total energy expenditure (TEE) and physical activity level (PAL) is important for treatment of patients with type 2 diabetes mellitus (T2DM). However, the validity of accelerometers (ACC) and physical activity questionnaires (PAQ) for estimating TEE and PAL remains unknown in elderly populations with T2DM. We evaluated the accuracy of TEE and PAL results estimated by an ACC (TEEACC and PALACC) and a PAQ (TEEPAQ and PALPAQ) in elderly patients with T2DM. METHODS: Fifty-one elderly patients with T2DM (aged 61-79 years) participated in this study. TEEACC was calculated with PALACC using a triaxial ACC (Active style Pro HJA-750c) over 2 weeks and predicted basal metabolic rate (BMR) by Ganpule's equation. TEEPAQ was estimated using predicted BMR and the PALPAQ from the -Japan Public Health Center Study-Long questionnaire. We compared the results to TEEDLW measured with the doubly labeled water (DLW) method and PALDLW calculated with BMR using indirect calorimetry. RESULTS: TEEDLW was 2,165 ± 365 kcal/day, and TEEACC was 2,014 ± 339 kcal/day; TEEACC was strongly correlated with TEEDLW (r = 0.87, p < 0.01) but significantly underestimated (-150 ± 183 kcal/day, p < 0.05). There was no significant difference in TEEPAQ and TEEDLW (-49 ± 284 kcal/day), while the range of difference seemed to be larger than TEEACC. PALDLW, PALACC, and PALPAQ were calculated to be 1.71 ± 0.17, 1.69 ± 0.16, and 1.78 ± 0.24, respectively. -PALACC was strongly correlated with PALDLW (r = 0.71, p < 0.01), and there was no significant difference between the 2 values. PALPAQ was moderately correlated with PALDLW (r = 0.43, p < 0.01) but significantly overestimated. Predicted BMR was significantly lower than the BMR -measured by indirect calorimetry (1,193 ± 186 vs. 1,262 ± 155 kcal/day, p < 0.01). CONCLUSIONS: The present ACC and questionnaire showed acceptable correlation of TEE and PAL compared with DLW method in elderly patients with T2DM. Systematic errors in estimating TEE may be improved by the better equation for predicting BMR.
Comprehensive geriatric intervention in community-dwelling older adults: a cluster-randomized controlled trial. International-journal Peer-reviewed

Yuya Watanabe, Yosuke Yamada, Tsukasa Yoshida, Keiichi Yokoyama, Motoko Miyake, Emi Yamagata, Minoru Yamada, Yasuko Yoshinaka, Misaka Kimura

Journal of cachexia, sarcopenia and muscle　11　(1)　26-37　2020/02

DOI： 10.1002/jcsm.12504 　

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BACKGROUND: In longevity societies, one of the most serious social issues is sarcopenia and/or frailty. Preventing them is important for maintaining independence and quality of life in the older population. This study investigated the effect of a self-monitoring comprehensive geriatric intervention programme (CGIP) on physical function and muscle size in community-dwelling older adults. We compared the effects of a CGIP using weekly class-styled (CS) sessions and a home-based (HB) programme. METHODS: The 526 participants were randomized into one of two groups (CS 251, HB 275) based on their residential districts. We conducted a 12 week CGIP, which consisted of low-load resistance exercise, physical activity increments, oral function improvements, and a nutritional guide. All participants were encouraged to attend two 90 min lectures that included instructions on the CGIP. They were provided with exercise materials (triaxial-accelerometers/pedometers, ankle weights, and elastic bands) and diary logs. The CS group attended 90 min weekly sessions and independently executed the programme on other days, whereas the HB group only received instructions on how to execute the programme. Physical functions, such as knee extension strength (KES), normal and maximum walking speed, the timed up-and-go test, and anterior thigh muscle thickness (MT), were measured and analysed using intention-to-treat analysis before and after the 12 week intervention. RESULTS: Of the 526 participants identified, 517 (CS 243 age 74.0 ± 5.4 women 57.2%, HB 274 age 74.0 ± 5.6 women 58.8%) were enrolled. Nine (CS 8, HB 1) were excluded from the analysis because they did not participate in the pre-intervention measurements. Both interventions significantly improved KES (CS 18.5%, HB 10.6%), normal walking speed (CS 3.7%, HB 2.8%), and MT (CS 3.2%, HB 3.5%). Greater improvement of KES was observed in the CS group (P = 0.003). Maximum walking speed (CS 4.7%, HB 1.8%; P = 0.001) and timed up-and-go (CS -4.7%, HB -0.2%; P < 0.001) significantly improved in the CS group only. CONCLUSIONS: The intervention was effective in preventing sarcopenia and/or frailty. Most physical functions and MT improved after both interventions. The HB intervention is cost-effective and may help prevent sarcopenia and/or frailty in the large older population.
Acute effect of multiple sets of fatiguing resistance exercise on muscle thickness, echo intensity, and extracellular-to-intracellular water ratio. International-journal Peer-reviewed

Masashi Taniguchi, Yosuke Yamada, Noriaki Ichihashi

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme　45　(2)　213-219　2020/02

DOI： 10.1139/apnm-2018-0813 　

ISSN： 1715-5312

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Resistance exercise (RE) causes an acute increase of the muscle thickness (MT) considered to relate to an increase in tissue water content. Segmental bioelectrical impedance spectroscopy (S-BIS) is a tool used to noninvasively assess intra- and extra-cellular water (ICW and ECW, respectively) of a given limb segment. The purpose of the present study was to examine the change of MT, ultrasound echo intensity (EI), ICW, and ECW after 3 sets of exhaustive RE. Eighteen untrained young males (age, 25.4 ± 4.1 years) performed RE consisting of 3 sets of knee extension concentric and eccentric contractions with 80% of 1-repetition maximum to failure. The MT and EI of the quadriceps measured by ultrasonography, and ECW/ICW ratio of the thigh assessed by S-BIS before (baseline) and after each set of RE (PostEx1, 2, and 3). The changes (Δ) in MT, EI, and ECW/ICW ratio were calculated as values of PostEx minus baseline values. The values of MT, EI, and ECW/ICW ratio at PostEx3 were significantly higher than baseline (effect size: MT, 1.11; EI, 0.47; and ECW/ICW ratio, 0.45). In addition, ΔMT was significantly and moderately correlated with ΔECW/ICW ratio (r = 0.61). Integrated data showed weak but significant correlation between ΔEI and ΔECW/ICW ratio as well (r = 0.31). The present results suggest multiple sets of exhaustive knee extension RE induce the acute increase of EI and ECW/ICW ratio as well as MT. The acute increase of muscle size after exercise can be at least partly explained by relative ECW increase.
Effects of Capsinoids on Daily Physical Activity, Body Composition and Cold Hypersensitivity in Middle-Aged and Older Adults: A Randomized Study. International-journal Peer-reviewed

Keiichi Yokoyama, Yosuke Yamada, Yasunori Akamatsu, Yasuko Yoshinaka, Akiko Yamamoto, Tomonori Koizumi, Kana Ohyama, Katsuya Suzuki, Masaki Hashimoto, Hitoshi Sato, Misaka Kimura

Nutrients　12　(1)　2020/01/14

DOI： 10.3390/nu12010212 　

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Sedentary/inactive lifestyle leads middle-aged and older adults to metabolic syndrome and frailty. Capsinoids from nonpungent chili pepper cultivar have been reported to reduce body fat mass, promote metabolism, and improve unidentified complaints of chills. Additionally, they have an anti-inflammation effect; therefore, we hypothesized that continuous oral ingestion of capsinoids alleviates age-related inflammation in the brain and improves the physical activity (PA) in middle-aged and older adults. In our double-blind human study, 69 participants (17 male, 52 female; mean age: 74.1 ± 7.7 years; range: 52-87 years) were administered either 9 mg of capsinoids which were extracted from pepper fruit variety CH-19 Sweet (Capsicum anuum L.) (CP group), or a placebo (PL group) daily over a 3 month period. In an animal study, PA and inflammation-related mRNA expression in the brain were examined in 5-week (young) and 53-week (old) aged mice fed a diet with or without 0.3% dihydrocapsiate, a type of capsinoids, for 12 weeks. In a human study, capsinoids intake did not increase the amount of light-to-moderate PA less than 6.0 metabolic equivalents (METs) (CP: 103.0 ± 28.2 at baseline to 108.2 ± 28.3 at 12 weeks; PL: 104.6 ± 19.8 at baseline to 115.2 ± 23.6 at 12 weeks, METs × hour/week); however, in participants exhibiting an inactive lifestyle, it showed significant increase (CP: 84.5 ± 17.2 at baseline to 99.2 ± 24.9 at 12 weeks; PL: 99.7 ± 23.3 at baseline to 103.8 ± 21.9 at 12 weeks). The energy expenditure in physical activity also improved in the inactive CP group (CP: 481.2 ± 96.3 at baseline to 562.5 ± 145.5 at 12 weeks; PL: 536.8 ± 112.2 at baseline to 598.6 ± 127.6 at 12 weeks; kcal/day). In all participants, CP showed reduced waist circumference, percent body fat, and visceral fat volume; in addition, chills were eased in subjects aged 80 years and older. The older mice fed capsinoids showed increased locomotion activity, decreased inflammation, and oxidative stress in the brain. The results suggest that the continuous oral ingestion of capsinoids gains PA through anti-inflammation effect in the brain as well as reduces fat accumulation and chills in inactive and older humans.
Physical functions, physical activity, and cognitive functions in communitydwelling older people with driving cessation: The Nakagawa Study

Kose, Y., Ikenaga, M., Yamada, Y., Takeda, N., Morimura, K., Kimura, M., Kiyonaga, A., Higaki, Y., Group, H.T.T.N.S.

Japanese Journal of Physical Fitness and Sports Medicine　69　(1)　2020

DOI： 10.7600/JSPFSM.69.181 　
A Longitudinal Study on Cognitive Decline Judgement based on Duration of Physical Activities

Nishiyama Takashi, Kimura Misaka, Higaki Yasuki, Kose Yujiro, Yamanishi Kohei, Sato Yoshikuni, Sumi Sadayuki, Ikenaga Masahiro, Yamada Yosuke, Takeda Noriko, Morimura Kazuhiro

The Transactions of Human Interface Society　22　(3)　351-360　2020
Publisher: Human Interface Society
DOI： 10.11184/his.22.3_351 　

ISSN： 1344-7262

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With regard to the decline in cognitive function associated with the aging of the elderly individuals, we newly find a feature value that is captured by the change in the amount of activity, and obtain the accuracy of the judgment. In other words, we propose a feature quantity "1 / T index" focusing on the duration T of activity, and determine the accuracy of cognitive decline in individuals. Specifically, the difference between the 1 / T index value of an individual 4 years ago and the same index value 4 years later is compared with a preset difference threshold. The target data are activity data and cognitive function evaluation values (MMSE scores) obtained from elderly individuals before and after aging for 4 years. The group that was initially cognitive healthy (with an MMSE value of 27 or higher) and an average of 75 years old is divided into two groups. One is the cognitive decline group that became cognitive unhealthy after 4 years (MMSE value of 26 or lower), and the other is the non-decline group that remained cognitive healthy after 4 years. Then, we calculate the difference between the 1 / T index values of each group before and after 4 years. As a result of ROC analysis, AUC value 0.67 was confirmed. In addition, the most appropriate difference threshold of 0.006 was obtained, and as a result of the judgment of cognitive decline, sensitivity of 64.3% and specificity of 75.0% were confirmed.
[Physical parameters and physical function in older drivers with driving-related anxiety: the Nakagawa Study].

Yujiro Kose, Masahiro Ikenaga, Yosuke Yamada, Noriko Takeda, Kazuhiro Morimura, Misaka Kimura, Akira Kiyonaga, Yasuki Higaki

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics　57　(4)　475-483　2020

DOI： 10.3143/geriatrics.57.475 　

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AIM: This study investigated whether driving-related anxiety was independently associated with physical parameters and physical function in community-dwelling older people. METHODS: Participants were 523 community-dwelling older drivers (353 men and 170 women). Participants self-reported driving-related anxiety when driving in familiar environments, and completed physical assessments: visual impairment, auditory impairment, cerebrovascular disease (CVD), hand grip strength, knee extension strength, timed up and go (TUG), chair stand, one leg standing with open eyes, functional reach, vertical jump, preferred gait speed and maximal gait speed. Participants were divided into a driving-related anxiety group (72.8±5.1 years; 21 men, seven women) and a no-anxiety (non-anxiety) group (70.7±4.7 years; 325 men, 163 women). We examined physical performance differences between the anxiety and non-anxiety groups using analysis of covariance, and investigated the relationship between anxiety, physical function and performance using logistic regression analysis (forward stepwise selection). RESULTS: The driving-related anxiety group was significantly older, with higher rates of visual impairment, auditory impairment, and CVD than the non-anxiety group. The anxiety group exhibited independently poorer TUG and maximal gait speed (P<0.05 for both). Logistic regression analysis revealed significant relationships between anxiety and visual impairment (odds ratio [OR]: 5.6, 95% confidence interval [CI]: 2.5-12.6), auditory impairment (OR: 3.0, 95% CI: 1.3-7.0), TUG (OR: 1.46, 95% CI: 1.1-1.9) and CVD (OR: 3.1, 95% CI: 1.0-9.4) (P<0.05 for all). CONCLUSIONS: Driving-related anxiety was significantly associated with worse physical performance, visual impairment, auditory impairment, and CVD in community-dwelling older drivers.
地域高齢者における咀嚼能力と主観的な口腔健康度との関連 Peer-reviewed

和田理紗子, 渡邉大輝, 吉田司, 横山慶一, 吉中康子, 渡邊裕也, 吉田光由, 山田陽介, 木村みさか

日本病態栄養学会誌　23　(Suppl.)　S-41　2020/01
Publisher: (一社)日本病態栄養学会
ISSN： 1345-8167
Relationship between daily number of steps and lower-limb muscle quantity and quality, and physical function in community-dwelling older adults Peer-reviewed

Yuya Watanabe, Yosuke Yamada, Tsukasa Yoshida, Keiichi Yokoyama, Yasuko Yoshinaka, Yasuko Okayama, Misaka Kimura

Doshisha Journal of Health & Sports Science　accepted　(12)　29-36　2020
Publisher: Society of Health and Sports Science, Doshisha University
DOI： 10.14988/00027494 　

ISSN： 1883-4132
Metabolic equivalents of body weight resistance exercise with slow movement in older adults using indirect calorimetry Peer-reviewed

Nakagata, T., Yamada, Y., Naito, H.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme　44　(11)　1254-1257　2019/11

DOI： 10.1139/apnm-2018-0882 　

ISSN： 1715-5312
大阪府摂津市の中高年におけるフレイルの実態大阪府健康格差解決プログラム促進事業

吉田司, 西信雄, 宮地元彦, 渡邉大輝, 黒谷佳代, 瀧本秀美, 山田陽介, 島田秀和, 澤田奈緒美, 阿部圭一

日本公衆衛生学会総会抄録集　78回　409-409　2019/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
理学療法士に必要な栄養学の知識 5 食事・栄養摂取の評価法

山田陽介

理学療法(東京)　36　(10)　931-942　2019/10
Publisher: メディカルプレス
ISSN： 0910-0059
Physical Activity and/or High Protein Intake Maintains Fat-Free Mass in Older People with Mild Disability; the Fukuoka Island City Study: A Cross-Sectional Study. International-journal Peer-reviewed

Takae R, Hatamoto Y, Yasukata J, Kose Y, Komiyama T, Ikenaga M, Yoshimura E, Yamada Y, Ebine N, Higaki Y, Tanaka H

Nutrients　11　(11)　2019/10

DOI： 10.3390/nu11112595 　

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Body composition changes with age, with fat mass (FM) increasing and fat-free mass (FFM) decreasing. Higher physical activity and high or adequate protein intake are thought to be beneficial in preventing the loss of skeletal muscle mass in the elderly. We aimed to investigate the relationships between physical activity, protein intake, and FFM in older people with mild disability. Total energy expenditure (TEE) under free-living conditions was assessed using the doubly-labelled water (DLW) method, and physical activity was measured using a triaxial accelerometer. Dietary intake was assessed using a self-recorded food intake diary during the DLW period. Percent FFM was significantly positively correlated with protein intake and physical activity level (PAL) after adjustment for age and sex (protein intake r = 0.652, p < 0.001, PAL r = 0.345, p = 0.011). In multiple linear regression analysis, when PAL, moderate-to-vigorous physical activity (MVPA), or protein intake were included, 31%, 32%, and 55%, respectively, of the variation in %FFM was explained. Moreover, the addition of both PAL/MVPA and protein intake explained 61%/60%, respectively, of the variation in %FFM. Either protein intake above the currently recommended level or higher levels of physical activity would be beneficial for the maintenance of high %FFM.
Habitual Light-intensity Physical Activity and ASC Methylation in a Middle-aged Population. International-journal Peer-reviewed

Yuichiro Nishida, Megumi Hara, Yasuki Higaki, Naoto Taguchi, Kazuyo Nakamura, Hinako Nanri, Mikako Horita, Chisato Shimanoe, Jun Yasukata, Nobuyuki Miyoshi, Yosuke Yamada, Ken Higashimoto, Hidenobu Soejima, Keitaro Tanaka

International journal of sports medicine　40　(10)　670-677　2019/09

DOI： 10.1055/a-0965-1374 　

ISSN： 0172-4622

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Apoptosis-associated, speck-like protein containing a caspase recruitment domain (ASC) plays an important role in inflammatory cytokine synthesis in peripheral blood mononuclear cells (PBMCs), and the expression of ASC is suppressed by increased methylation of its CpG sites. The current study investigated the longitudinal association of replacing sedentary time with light-intensity physical activity (LPA) or moderate to vigorous-intensity physical activity (MVPA) on the ASC methylation in middle-aged people. We investigated 1 238 individuals who participated in baseline and 5-year follow-up surveys of a population-based cohort study. Sedentary, LPA and MVPA time were objectively measured using accelerometers. ASC methylation in PBMCs was measured by pyrosequencing. Using a multiple linear regression and employing an isotemporal substitution model, the longitudinal associations of changes in the sedentary time, LPA and MVPA on the changes in the ASC methylation were analyzed after adjusting for potential confounders. Substituting 60 min per day of LPA for sedentary time was associated with 1.17 times (95% confidence interval 1.07, 1.27) higher ASC methylation levels (mean of 7 CpG sites, P<0.001). However, such effects were not seen for MVPA. These results suggest that substituting LPA for sedentary time may be linked with increased (favorable) ASC methylation as a potential biomarker of systemic inflammation.
骨格筋における筋厚・筋輝度・細胞外液比の加齢性変化 Peer-reviewed

谷口匡史, 福元喜啓, 山田陽介, 澤野翔一朗, 南征吾, 池添冬芽, 木村みさか, 市橋則明

理学療法学　46　(Suppl.1)　O10-2　2019/08
Publisher: (公社)日本理学療法士協会
ISSN： 0289-3770

eISSN： 2189-602X
高齢者における身体活動量と筋エコー輝度の加齢変化との関連 4年間の縦断研究 Peer-reviewed

福元喜啓, 山田陽介, 池添冬芽, 渡邊裕也, 谷口匡史, 澤野翔一朗, 南征吾, 浅井剛, 木村みさか, 市橋則明

理学療法学　46　(Suppl.1)　O10-3　2019/08
Publisher: (公社)日本理学療法士協会
ISSN： 0289-3770

eISSN： 2189-602X
Changes in physical function in older adults in a low-cost nursing home during a 5-year period : comparison between individuals retaining independence and those certified for long-term care and/or support

渡邊裕也, 吉田司, 吉中康子, 横山慶一, 山田陽介, 三宅基子, 木村みさか

応用老年学　13　(1)　44-53　2019/08
Publisher: 日本応用老年学会
ISSN： 1882-6245
Accuracy of 12 Wearable Devices for Estimating Physical Activity Energy Expenditure Using a Metabolic Chamber and the Doubly Labeled Water Method: Validation Study. Peer-reviewed

Murakami H, Kawakami R, Nakae S, Yamada Y, Nakata Y, Ohkawara K, Sasai H, Ishikawa-Takata K, Tanaka S, Miyachi M

JMIR mHealth and uHealth　7　(8)　e13938　2019/08

DOI： 10.2196/13938 　

ISSN： 2291-5222
新たな骨格筋・サルコペニア評価法の確立

赤木亮太, 江間諒一, 山田陽介

芝浦工業大学特別教育・研究報告集(CD-ROM)　2018　403‐406　2019/07/31

ISSN： 2185-7326
Estimation of Energy Intake by a Food Frequency Questionnaire: Calibration and Validation with the Doubly Labeled Water Method in Japanese Older People. International-journal Peer-reviewed

Daiki Watanabe, Hinako Nanri, Hiroyuki Sagayama, Tsukasa Yoshida, Aya Itoi, Miwa Yamaguchi, Keiichi Yokoyama, Yuya Watanabe, Chiho Goto, Naoyuki Ebine, Yasuki Higaki, Kazuko Ishikawa-Takata, Misaka Kimura, Yosuke Yamada

Nutrients　11　(7)　2019/07/09

DOI： 10.3390/nu11071546 　

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Accurate assessments of a target population's energy intake (EI) are essential to prevent poor nutritional status. However, self-reported dietary records (DRs) or food frequency questionnaires (FFQs) are not always accurate, thereby requiring validation and calibration studies. This study aimed to validate the EI estimated by a FFQ using the doubly labeled water (DLW) method. Participants were 109 Japanese older adults (50 women and 59 men) aged 65-88 years. The EI was obtained by a DR and 47-item FFQ over 1 year. The total energy expenditure (TEE) was measured by DLW for ~2 weeks. EI was significantly lower than TEE (p < 0.01); ratios of EI assessed by DR and FFQ against TEE were 0.91 ± 0.17 and 0.82 ± 0.22, respectively. TEE was significantly and moderately correlated with the EI estimated by the DR (r = 0.45, p < 0.01) and FFQ (r = 0.37, p < 0.01). Furthermore, the EI correlation coefficients estimated by DR and the FFQ in this study were not significantly different (p = 0.46). The EI/TEE ratio was significantly and negatively correlated with the body mass index (BMI). In conclusion, EI estimated with a DR or FFQ modestly correlated with TEE, and calibrating EI with a developed equation in this study can attenuate the underestimation of EI.
おさえておきたい理論編メタボとフレイルのアセスメント

吉田司, 山田陽介

臨床栄養　22‐31　2019/06/25

ISSN： 0485-1412
Implications for Exercise Prescription and Health Promotion Using Body Mass Resistance Training with Slow Movement

中潟崇, 山田陽介, 内藤久士

デサントスポーツ科学　40　146‐154-154　2019/06/07
Publisher:
ISSN： 0285-5739
Relationship Between Physical Fitness at the End of Preseason and the Inseason Game Performance in Japanese Female Professional Baseball Players. International-journal Peer-reviewed

Watanabe Y, Yamada Y, Yoshida T, Matsui T, Seo K, Azuma Y, Hiramoto M, Miura Y, Fukushima H, Shimazu A, Eto T, Saotome H, Kida N, Morihara T

Journal of strength and conditioning research　33　(6)　1580-1588　2019/06

DOI： 10.1519/JSC.0000000000002024 　

ISSN： 1064-8011

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Watanabe, Y, Yamada, Y, Yoshida, T, Matsui, T, Seo, K, Azuma, Y, Hiramoto, M, Miura, Y, Fukushima, H, Shimazu, A, Eto, T, Saotome, H, Kida, N, and Morihara, T. Relationship between physical fitness at the end of preseason and the inseason game performance in Japanese female professional baseball players. J Strength Cond Res 33(6): 1580-1588, 2019-This study examined anthropometric and fitness profiles of Japanese female professional baseball players and investigated the relationship between players' physical fitness and inseason game performance. Fifty-seven players who were registered in the Japan Women's Baseball League (JWBL) participated. Height, body mass, grip strength, back strength, knee extension and flexion strength, hamstring extensibility, vertical jump height, and horizontal jump distance were measured at preseason (February and March) in 2013. Game performance during the 2013 season (March-November) was obtained from official JWBL statistics. Vertical jump height showed significant positive correlations with individual performance records (e.g., total bases [r = 0.551], slugging percentage [r = 0.459], and stolen bases [r = 0.442]). Similar relationships were observed between horizontal jump distance and performance statistics in most cases. By contrast, grip, back, and lower-limb strength, as well as hamstring extensibility were not significantly correlated with game performance. Stepwise regression analysis selected vertical jump height as an independent variable, significantly correlating with several game performance measures (e.g., total bases: adjusted R = 0.257). Also, vertical jump height and body mass index were identified as independent variables significantly associated with stolen bases (adjusted R = 0.251). Maximal jump performance, rather than simple isometric muscle strength or flexibility, is a good performance test that can be used at the end of preseason to predict inseason batting and stolen base performance. Our findings demonstrate the importance of constructing preseason training programs to enhance lower-limb muscular power that is linked to successful inseason performance in female baseball players.
The effects of rapid weight loss and 3-h recovery on energy expenditure, carbohydrate, and fat oxidation in boxing athletes Peer-reviewed

Sagayama, H., Yoshimura, E., Yamada, Y., Tanaka, H.

Journal of Sports Medicine and Physical Fitness　59　(6)　1018-1025　2019/06

DOI： 10.23736/S0022-4707.18.08677-2 　

ISSN： 0022-4707
Consumption of green tea but not coffee is associated with the oral health-related quality of life among an older Japanese population: Kyoto-Kameoka cross-sectional study. International-journal Peer-reviewed

Hinako Nanri, Yosuke Yamada, Aya Itoi, Emi Yamagata, Yuya Watanabe, Tsukasa Yoshida, Motoko Miyake, Heiwa Date, Kazuko Ishikawa-Takata, Mitsuyoshi Yoshida, Takeshi Kikutani, Misaka Kimura

European journal of clinical nutrition　73　(4)　577-584　2019/04

DOI： 10.1038/s41430-018-0186-y 　

ISSN： 0954-3007

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BACKGROUND/OBJECTIVES: The consumption of both green tea and coffee is known to induce positive health effects; however, it remains unclear whether there is an association between the consumption of these beverages and oral health-related quality of life (OHRQoL). Thus, the present study investigated the relationship between the consumption of green tea and coffee and OHRQoL. SUBJECTS/METHODS: We analyzed cross-sectional baseline data in 2012. The subjects were 7514 Japanese participants (3563 men, 3951 women; ≥65 years of age). Each subject completed a validated self-administered questionnaire that included items on the frequency of the consumption of green tea and coffee. OHRQoL was evaluated using the self-reported General Oral Health Assessment Index (GOHAI), which assesses oral health problems in older adults. A GOHAI score <50 points was defined as a poor OHRQoL. RESULTS: Following adjustment for age, body mass index, total energy intake, alcohol, smoking, medication use, coffee, and fruit and vegetable consumption, increased consumption of green tea showed a strong positive association with the GOHAI score in both men and women (Ptrend < 0.001 in both). In contrast, after adjusting for all factors, no statistically significant association was observed between coffee consumption and the GOHAI score in men (Ptrend = 0.538) or women (Ptrend = 0.607). The respective multivariate-odds ratios (95% confidence intervals) for a poor OHRQoL associated with green tea consumption frequencies of none, <1 cup/day, 1-2 cups/day, and ≥3 cups/day were 1.00, 1.01 (0.80-1.27), 0.95 (0.74-1.21), and 0.78 (0.61-0.99) (Ptrend = 0.024) in men, and 1.00, 1.19 (0.90-1.57), 0.98 (0.74-1.29), and 0.86 (0.67-1.12) (Ptrend = 0.014) in women. CONCLUSIONS: Regardless of sex, green tea consumption was positively associated with the GOHAI score. Therefore, ≥3 cups/day of green tea may reduce the risk of a poor OHRQoL, especially in men.
Validation of Energy and Nutrition Intake in Japanese Elderly Individuals Estimated Based on a Short Food Frequency Questionnaire Compared against a 7-day Dietary Record: The Kyoto-Kameoka Study. International-journal Peer-reviewed

Daiki Watanabe, Hinako Nanri, Tsukasa Yoshida, Miwa Yamaguchi, Mayu Sugita, Yoshizu Nozawa, Yuki Okabe, Aya Itoi, Chiho Goto, Yosuke Yamada, Kazuko Ishikawa-Takata, Hisamine Kobayashi, Misaka Kimura, Kyoto-Kameoka Study Kyoto-Kameoka Study Group

Nutrients　11　(3)　2019/03/22

DOI： 10.3390/nu11030688 　

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To determine the association between geriatric disorders and dietary intake, validation of a food frequency questionnaire (FFQ) for elderly individuals is needed. We compared energy and nutrient intakes derived from dietary records (DR) and FFQ in an elderly population and compared the data against results from middle-aged individuals (30⁻68 years) from a previous study. Current participants included 65 women and 78 men (65⁻88 years) who completed FFQ and 7-day DR in a subpopulation of the Kyoto-Kameoka study. Our FFQ was created for middle-aged individuals. To validate the FFQ, we investigated equivalent precision by comparing the correlation coefficients between the present and previous study. Median correlations for energy and nutrient intake between the DR and FFQ in the current and previous studies were 0.24 and 0.30 (p = 0.329) in women and 0.24 and 0.28 (p = 0.399) in men, respectively. The median ratio of FFQ to DR for these intakes were also similar. The accuracy and precision of the FFQ for energy and nutrient intake in elderly individuals did not differ compared with previous findings in a middle-aged population. A validation study evaluating energy and nutrient intake using recovery biomarkers is further needed.
日本人COPD患者における二重標識水(DLW)法による総エネルギー消費量測定に基づくエネルギー必要量の推定

佐藤秀彰, 仲村秀俊, 赤上巴, 與儀実大, 相馬真智香, 三尾友彦, 宮下起幸, 永田真, 中江悟司, 西田優紀, 山田陽介, 田中茂穂, 勝川史憲

日本呼吸器学会誌　8　(増刊)　317-317　2019/03
Publisher: (一社)日本呼吸器学会
ISSN： 2186-5876

eISSN： 2186-5884
COPDにおける身体活動性と関連する臨床指標

赤上巴, 仲村秀俊, 佐藤秀彰, 三尾友彦, 内田義孝, 小宮山謙一郎, 井上快児, 新津守, 永田真, 中江悟司, 西田優紀, 山田陽介, 佐々木敏, 田中茂穂, 勝川史憲

日本呼吸器学会誌　8　(増刊)　317-317　2019/03
Publisher: (一社)日本呼吸器学会
ISSN： 2186-5876

eISSN： 2186-5884
Hip, Trunk, and Shoulder Rotational Range of Motion in Healthy Japanese Youth and High-school Baseball Pitchers. Peer-reviewed

Machiko Hiramoto, Toru Morihara, Yoshikazu Kida, Tomoyuki Matsui, Yoshikazu Azuma, Kazuya Seo, Tetsuya Miyazaki, Yuya Watanabe, Yoshihiro Kai, Yosuke Yamada, Noriyuki Kida, Shuhei Morifusa

Progress in Rehabilitation Medicine　4　1-9　2019/03

DOI： 10.2490/prm.20190009 　

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Objective: The rotational range of motion (ROM) in the upper extremities, trunk, and lower extremities is important for throwing motion. However, unlike for the shoulders, the differences relating to age and throwing-side in trunk and lower extremity ROMs in baseball pitchers are unknown. This study examined the effects of age and dominance on the ROMs of the trunk and upper and lower extremities. Methods: The study included 356 young baseball pitchers aged 9-17 years who participated in off-season baseball camps. The subjects comprised 155 youth pitchers (aged 9-14 years) and 201 high-school pitchers (aged 15-17 years) who were able to throw at full force without pain. The neck, shoulder, trunk, and hip rotational ROMs on the dominant and non-dominant side were measured by well-trained physical therapists. The differences between throwing sides and between age groups were examined using two-way analysis of variance. Results: Shoulder external rotation on the dominant side was greater than that on the non-dominant side. Shoulder external and internal rotational ROMs were maintained regardless of age, whereas the trunk rotational ROM significantly increased with age. Conclusions: The effects of age and dominance on ROMs of the neck, trunk, and upper and lower extremities in Japanese youth and high-school baseball pitchers were clarified. These data could be used as a specific reference and as target values for the rehabilitation of throwing injuries in young athletes.
Energy Expenditure of a Single Sit-to-Stand Movement with Slow Versus Normal Speed Using the Different Frequency Accumulation Method. International-journal Peer-reviewed

Nakagata T, Yamada Y, Hatamoto Y, Naito H

Medicina (Kaunas, Lithuania)　55　(3)　2019/03

DOI： 10.3390/medicina55030077 　

ISSN： 1010-660X

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Background and objectives: The purpose of this study was to compare the energy expenditures (EE) of a single sit-to-stand (STS) movements with slow and normal speeds using a multi-stage exercise test. Materials and Methods: Twelve young males, aged 21⁻27 years (age, 23.0 ± 1.7 years; height, 171.2 ± 6.1 cm; weight, 64.3 ± 5.6 kg), performed repeated 3-s stand-up and 3-s sit-down (slow) or 1-s stand-up and 1-s sit-down (normal) movement on two different days with random order. All the participants completed multi-stage tests at different STS frequencies per minute. The slope and intercept of the linear regression relationship between the EE (kcal/min) and the STS frequency were obtained, and the slope of the regression was quantified as the EE of an STS. Results: The metabolic equivalents (METs) of the STS-slow was 4.5 METs for the frequency of 10 times/min (in total 1 min), and the net EE was 5.00 ± 1.2 kcal/min. The net EE of the STS-slow was 0.37 ± 0.12 kcal, which was significantly greater than that during the STS-normal (0.26 ± 0.06 kcal). The difference between the EEs of the STS-slow and STS-normal was significantly greater in taller and heavier subjects. Conclusions: We concluded that the intensity of STS-slow movement is moderate, and the EE during an STS-slow (0.37 ± 0.12 kcal) is higher than that during an STS-normal (0.26 ± 0.06 kcal). Our study results will help exercise and/or health professionals prescribe physical activity programs using STS movement for healthy young population groups.
Effect of Thoracic Gas Volume Changes on Body Composition Assessed by Air Displacement Plethysmography after Rapid Weight Loss and Regain in Elite Collegiate Wrestlers. International-journal Peer-reviewed

Emi Kondo, Keisuke Shiose, Yosuke Yamada, Takuya Osawa, Hiroyuki Sagayama, Keiko Motonaga, Shiori Ouchi, Akiko Kamei, Kohei Nakajima, Hideyuki Takahashi, Koji Okamura

Sports (Basel, Switzerland)　7　(2)　2019/02/19

DOI： 10.3390/sports7020048 　

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We investigated the effect of rapid weight loss (RWL) and weight regain (WR) on thoracic gas volume (VTG) and body composition assessment using air displacement plethysmography (ADP) in male wrestlers. Eight male elite collegiate wrestlers completed a RWL regimen (6% of body mass) over a 53-h period, which was followed by a 13-h WR period. ADP was used at three time points (baseline (T1), post-RWL (T2) and post-WR (T3)) according to the manufacturer's testing recommendations. The total body water and bone mineral content were estimated using the stable isotope dilution method and dual energy X-ray absorptiometry, respectively, at the same time points. Body composition was assessed with two-component (2C) or four-component (4C) models using either the measured VTG (mVTG) or predicted VTG (pVTG). Measured VTG increased from T1 to T2 (0.36 ± 0.31 L, p < 0.05) and decreased from T2 to T3 (-0.29 ± 0.15 L, p < 0.01). However, the changes in fat mass and fat free mass, which were calculated by both 2C and 4C models, were not significantly different when compared between calculations using mVTG and those using pVTG. Our results indicate that VTG significantly changes during RWL and WR, but both measured and predicted VTG can be used to assess changes in body composition during RWL and WR.
Driving‐related anxiety and cognitive function in community‐dwelling older drivers: the Nakagawa study

古瀬裕次郎, 古瀬裕次郎, 池永昌弘, 山田陽介, 武田典子, 森村和浩, 町田由紀子, 栗山緑, 三好伸幸, 木村みさか, 木村みさか, 清永明, 清永明, 檜垣靖樹, 檜垣靖樹, 田中宏暁, 田中宏暁

健康支援　21　(1)　19-27　2019/02
Publisher: 日本健康支援学会
ISSN： 1345-0174
Development and validation of energy availability assessment tool for female athletes

Takako Koshimizu, Hideyuki Namba, Yoichi Hatamoto, Tsukasa Yoshida, Takashi Nakagata, Masashi Aruga, Yoshiki Takada, Yosuke Yamada

International Journal of Human Culture Studies　2019　(29)　845-850　2019/01/01
Publisher: Institute of Human Culture Studies, Otsuma Womens University
DOI： 10.9748/hcs.2019.845 　

eISSN： 2187-1930
女性アスリートの利用可能エネルギー不足アセスメントツールの開発と妥当性の検討

小清水孝子, 難波秀行, 畑本陽一, 吉田司, 中潟崇, 有賀雅史, 高田由基, 山田陽介

人間生活文化研究　(29)　845-849　2019
Publisher: 大妻女子大学人間生活文化研究所
eISSN： 2187-1930
多周波生体電気インピーダンス法を用いた日本人レスリング選手の体水分量推定の妥当性 Peer-reviewed

塩瀬圭佑, 近藤衣美, 山田陽介, 下山寛之, 西牧未央, 山下大地, 中嶋耕平, 高橋英幸, RWL Study Group

日本スポーツ栄養研究誌　12　107-107　2019/01
Publisher: (NPO)日本スポーツ栄養学会
ISSN： 2188-8922
運転を中止した高齢者の身体機能，身体活動量及び認知機能特性―福岡那珂川研究― Peer-reviewed

古瀬裕次郎, 池永昌弘, 山田陽介, 武田典子, 森村和浩, 木村みさか, 清永明, 檜垣靖樹, 田中宏暁, The Nakagawa, Study Group

体力科学（印刷中）　2019
Validity of One-Day Physical Activity Recall for Estimating Total Energy Expenditure in Elderly Residents at Long-Term Care Facilities: CLinical EValuation of Energy Requirements Study (CLEVER Study). Peer-reviewed

Yuki Nishida, Satoshi Nakae, Yosuke Yamada, Emi Kondo, Miwa Yamaguchi, Hiroyuki Shirato, Hirohiko Hirano, Satoshi Sasaki, Shigeho Tanaka, Fuminori Katsukawa

Journal of nutritional science and vitaminology　65　(2)　148-156　2019

DOI： 10.3177/jnsv.65.148 　

ISSN： 0301-4800

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Malnutrition is a severe problem among elderly residents living in long-term care facilities. A simple and accurate estimation for total daily energy expenditure (TEE) is required in order to provide them with an adequate amount of food. The purpose of this study was to validate a physical activity assessment tool for estimating TEE among elderly residents. The data of 58 subjects aged 69-99 y were analyzed in this study. The one-day physical activity recall was filled out by facility staff for a typical day. TEE was measured by the doubly labeled water (DLW) method (TEEDLW), and predicted by one-day physical activity recall using the basal metabolic rate (pTEEBMR) and body weight (pTEEBW). The TEEDLW, pTEEBMR and pTEEBW were 1,129±196 kcal/d, 1,186±251 kcal/d and 1,326±236 kcal/d, respectively. In a regression model, body weight, movement means and sex explained 39.0% of the variance in the difference between pTEEBMR and TEEDLW (p<0.05). Percentage of fat mass, body weight, and Barthel Index except mobility explained 47.3% of the variance in the difference between pTEEBW and TEEDLW (p<0.05). The current results suggested that pTEEBW is not recommended to estimate TEE because the error depends on body size, and pTEEBMR was significantly correlated with TEEDLW but also included systematic errors in elderly residents. In order to improve the accuracy of the present assessment to estimate TEE, it is necessary to establish a new equation of basal metabolic rate for elderly residents and consider sex and movement means to estimate TEE.
Total energy expenditure is comparable between patients with and without diabetes mellitus: Clinical Evaluation of Energy Requirements in Patients with Diabetes Mellitus (CLEVER-DM) Study. International-journal Peer-reviewed

Katsutaro Morino, Keiko Kondo, Shigeho Tanaka, Yuki Nishida, Satoshi Nakae, Yosuke Yamada, Satoshi Ugi, Keiko Fuse, Itsuko Miyazawa, Akiko Ohi, Kaori Nishida, Mika Kurihara, Masaya Sasaki, Naoyuki Ebine, Satoshi Sasaki, Fuminori Katsukawa, Hiroshi Maegawa

BMJ open diabetes research & care　7　(1)　e000648　2019

DOI： 10.1136/bmjdrc-2019-000648 　

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Objective: Assessment of total energy expenditure (TEE) is essential for appropriate recommendations regarding dietary intake and physical activity in patients with and without diabetes mellitus (DM). However, few reports have focused on TEE in patients with DM, particularly in Asian countries. Therefore, we evaluated TEE in Japanese patients with DM using the doubly labeled water (DLW) method and physical activity level (PAL). Research design and methods: In this cross-sectional observational study, we evaluated 52 patients with type 2 DM and 15 patients without DM. Free-living TEE was measured over 12-16 days by the DLW method, and PAL was calculated as TEE divided by the basal metabolic rate (BMR) as assessed by indirect calorimetry. The equivalence margin was defined as 5 kcal/kg/day. Results: The numbers of patients with DM treated with insulin, oral antidiabetic drugs, and diet were 18 (34.6%), 20 (38.5%), and 14 (26.9%), respectively. The mean±SD level of glycated hemoglobin was 6.9%±0.8% and 5.5%±0.3% in the DM and non-DM group, respectively (p<0.001). The mean body mass index was 23.3±3.0 and 22.7±2.1 kg/m2 in the DM and non-DM group, respectively. The mean TEE per kilogram body weight adjusted for sex and age was 36.5 kcal/kg/day and 37.5 kcal/kg/day in the DM and non-DM group, respectively, with no significant difference (mean difference, -1.0 kcal/kg/day; 95% CI -4.2 to 2.3 kcal/kg/day). The BMR tended to be higher in the DM than in the non-DM group (mean difference, 33 kcal/day; 95% CI, -15 to 80 kcal/day). The mean PAL adjusted for sex and age was 1.71 and 1.81 in the DM and non-DM group, respectively, without a significant difference (mean difference, -0.10; 95% CI -0.21 to 0.01). Conclusion: TEE was comparable between Japanese patients with and without DM. Trial registration number: UMIN000023051.
The International Atomic Energy Agency International Doubly Labelled Water Database: Aims, Scope and Procedures Peer-reviewed

Speakman, J.R., Pontzer, H., Rood, J., Sagayama, H., Schoeller, D.A., Westerterp, K.R., Wong, W.W., Yamada, Y., Loechl, C., Murphy-Alford, A.J.

Annals of Nutrition and Metabolism　75　(2)　114-118　2019

DOI： 10.1159/000503668 　

ISSN： 0250-6807
Energy expenditure, recovery oxygen consumption, and substrate oxidation during and after body weight resistance exercise with slow movement compared to treadmill walking Peer-reviewed

Nakagata, T., Yamada, Y., Naito, H.

Physiology International　105　(4)　371-385　2018/12

DOI： 10.1556/2060.105.2018.4.27 　
The perception of exertion and cardiorespiratory responses of rhythmic exercise performed to music compared with treadmill walking under three different tempos in postmenopausal women Peer-reviewed

Nakagata, T., Yoshinaka, Y., Yoshida, T., Yamada, Y., Yokoyama, K., Kimura, M.

Journal of Exercise Physiology Online　21　(6)　114-124　2018/12
Association of physical activity with age-related changes in muscle echo intensity in older adults: a 4-year longitudinal study. International-journal Peer-reviewed

Yoshihiro Fukumoto, Yosuke Yamada, Tome Ikezoe, Yuya Watanabe, Masashi Taniguchi, Shinichiro Sawano, Seigo Minami, Tsuyoshi Asai, Misaka Kimura, Noriaki Ichihashi

Journal of applied physiology (Bethesda, Md. : 1985)　125　(5)　1468-1474　2018/11/01

DOI： 10.1152/japplphysiol.00317.2018 　

ISSN： 8750-7587

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Ultrasonic echo intensity (EI), an easy-to-use measure of intramuscular fat and fibrous tissues, is known to increase with aging. However, age-related changes in EI have not been examined in a longitudinal design. The objective of this study was to investigate 4-yr longitudinal changes in the EI of the quadriceps femoris in older adults, based on difference in physical activity (PA). This study included 131 community-dwelling older adults with a mean age of 72.9 ± 5.2 yr. Subcutaneous fat thickness (FT), muscle thickness (MT), and EI of the quadriceps femoris were measured by ultrasound. Isometric knee extensor strength was also measured. PA was assessed using a questionnaire at baseline, and participants were classified into the high or low PA groups. In 4 yr, a significant decrease in FT, MT, and strength was observed in both groups ( P < 0.05), whereas a significant decrease in EI was observed only in the high PA group ( P < 0.05). Multiple linear regression analyses revealed that the difference in PA was a significant predictor of 4-yr changes in MT (β = 0.189, P = 0.031) and EI (β = -3.145, P = 0.045) but not in the body mass index, FT, or strength adjusted for potential confounders. The present findings suggest that greater PA has a positive effect on longitudinal changes in the MT and EI of the quadriceps femoris in older adults. In addition, greater PA may contribute to a future decrease in EI, and an increase in EI may not occur in 4 yr, even in older adults with lesser PA. NEW & NOTEWORTHY Our results suggest that greater physical activity (PA) may mitigate future changes in muscle thickness and echo intensity (EI). A decrease in EI over 4 yr was observed in older adults with greater PA, and an increase in EI was not observed, even in older adults with smaller PA. Several cross-sectional studies demonstrated an increase in EI with aging. Additionally, the results of our longitudinal study suggest that an age-related increase in EI may be moderated after the old-age period.
Intracellular-to-total water ratio explains the variability of muscle strength dependence on the size of the lower leg in the elderly. International-journal Peer-reviewed

Tsukasa Yoshida, Yosuke Yamada, Fumiko Tanaka, Takaki Yamagishi, Shigenobu Shibata, Yasuo Kawakami

Experimental gerontology　113　120-127　2018/11

DOI： 10.1016/j.exger.2018.09.022 　

ISSN： 0531-5565

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Bioelectrical impedance spectroscopy (BIS) can assess intracellular water (ICW) and total water (TW) in limbs. This study aimed to examine whether BIS can explain a part of the inter-individual variation of the muscle size-strength relationship in older adults. We analyzed the data of 79 participants aged 64-86 years. The maximal voluntary isometric torques of dorsiflexion and plantar flexion on the right side were measured. The anterior and posterior muscle thickness (MT) in the right lower leg was assessed using ultrasonography. The length of the right lower leg (L) was measured, and the ICW-to-TW ratio (ICW/TW) in the right lower leg was obtained using BIS. The MT was multiplied by L to represent an index of muscle volume (MV). Correlation and stepwise regression analyses were performed. The anterior and posterior MT × L significantly and positively correlated with the muscle torque of dorsiflexion and plantar flexion (r = 0.710 and 0.649, respectively, P < 0.001). In the stepwise regression analyses, ICW/TW was selected as a significant predictor of muscle torque independent of MT × L (P < 0.05) for both dorsiflexion and plantar flexion. Electrical parameters of BIS (membrane capacitance, characteristics frequency, and phase angle) in the lower leg also significantly correlated with muscle torques. In addition, the skeletal muscle mass index (appendicular lean mass/height2) was also associated with ICW/TW (P < 0.001). The present results suggest that ICW/TW explains the interindividual variations of the muscle size-strength relationship.
Metabolic equivalents of body weight resistance training with slow movement: Implications for exercise prescription and health promotion. Peer-reviewed

Nakagata T, Naito H, Yamada Y

Journal of Exercise Physiologyonline　21　(5)　29-38　2018/10
Simultaneous Validation of Seven Physical Activity Questionnaires Used in Japanese Cohorts for Estimating Energy Expenditure: A Doubly Labeled Water Study. Peer-reviewed

Sasai H, Nakata Y, Murakami H, Kawakami R, Nakae S, Tanaka S, Ishikawa-Takata K, Yamada Y, Miyachi M

Journal of epidemiology　28　(10)　437-442　2018/10

DOI： 10.2188/jea.JE20170129 　

ISSN： 0917-5040
Validity of a triaxial accelerometer and simplified physical activity record in older adults aged 64-96 years: a doubly labeled water study. International-journal Peer-reviewed

Yamada Y, Hashii-Arishima Y, Yokoyama K, Itoi A, Adachi T, Kimura M

European journal of applied physiology　118　(10)　2133-2146　2018/10

DOI： 10.1007/s00421-018-3944-6 　

ISSN： 1439-6319

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BACKGROUND: The aim was to examine the validity of a triaxial accelerometer (ACCTRI) and a simplified physical activity record (sPAR) in estimating total energy expenditure (TEE) and physical activity level (PAL) in older adults with the doubly labeled water (DLW) method. METHODS: A total of 44 Japanese elderly individuals (64-96 years), of which 28 were community-dwelling healthy adults with or without sporting habits (S or NS group) and 16 were care home residents with frailty (F group), were included in the study. Basal metabolic rate (BMR) was measured by indirect calorimetry, TEE was obtained by the DLW method, and PAL was calculated as TEE/BMR. Daily step count was monitored by a pedometer (Lifecorder). The 24-h average metabolic equivalent was assessed by ACCTRI and sPAR. RESULTS: The TEEDLW in men was 2704 ± 353, 2308 ± 442, and 1795 ± 338 kcal d-1, and that in women was 2260 ± 208, 1922 ± 285, and 1421 ± 274 kcal d-1 for the S, NS, and F groups, respectively. ACCTRI and sPAR systematically underestimated actual TEE (- 14.2 ± 11.6 and - 15.3 ± 12.3% for ACCTRI and sPAR, respectively). After diet-induced thermogenesis was taken into account for ACCTRI and sPAR, TEEDLW was significantly correlated with TEEACCTRI (R2 = 0.714) and TEEsPAR (R2 = 0.668). PALDLW was also significantly correlated with PALACCTRI (R2 = 0.438) and PALsPAR (R2 = 0.402). CONCLUSIONS: Age, living conditions, frailty, and sporting habits contribute to TEE and PAL in the elderly population. ACCTRI and sPAR underestimated TEE and PAL, and adequate corrections are required. The corrected ACCTRI and sPAR are both useful tools to estimate TEE and PAL.
Sex Difference in the Association Between Protein Intake and Frailty: Assessed Using the Kihon Checklist Indexes Among Older Adults. International-journal Peer-reviewed

Hinako Nanri, Yosuke Yamada, Tsukasa Yoshida, Yuki Okabe, Yoshizu Nozawa, Aya Itoi, Eiichi Yoshimura, Yuya Watanabe, Miwa Yamaguchi, Keiichi Yokoyama, Kazuko Ishikawa-Takata, Hisamine Kobayashi, Misaka Kimura

Journal of the American Medical Directors Association　19　(9)　801-805　2018/09

DOI： 10.1016/j.jamda.2018.04.005 　

ISSN： 1525-8610

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BACKGROUND: Dietary protein intake is inversely associated with physical frailty risk. However, it is unknown whether an association exists between dietary protein intake and comprehensive frailty. OBJECTIVE: To evaluate the association between protein intake and comprehensive frailty in older Japanese adults. DESIGN, SETTING AND PARTICIPANTS: This cross-sectional study included 5638 Japanese participants (2707 men and 2931 women) aged ≥65 years from Kameoka City, Kyoto, Japan. MEASUREMENTS: Dietary intake was estimated using a validated self-administered food frequency questionnaire. Comprehensive frailty was assessed using a 25-item Kihon Checklist (KCL), which comprised instrumental activities of daily living, mobility disability, malnutrition, oral or eating function, socialization and housebound, cognitive function, and depression domains. A KCL score of 4 to 6 was defined as prefrailty, and ≥7 as frailty. RESULTS: In women, but not in men, protein intake showed a lower prevalence for prefrailty (Q1-Q4, 40.2%, 34.3%, 34.3%, and 36.0%). Higher protein intake was associated with lower prevalence of frailty both in men (32.5%, 28.4%, 28.3%, and 27.3%) and women (35.7%, 31.4%, 27.6%, and 28.2%). Moreover, higher dietary protein intake decreased the odds ratio (OR) for frailty after adjustment for potential confounding factors in both men (OR for highest vs lowest quartile, 0.62; 95% CI, 0.43-0.89; P for trend = 0.016) and women (OR 0.64; 95% CI, 0.45-0.91; P for trend = 0.017). CONCLUSIONS/IMPLICATIONS: The higher dietary protein intake may be inversely associated with the prevalence of comprehensive frailty in Japanese men and women. Future studies are needed to examine associations of dietary protein intake within KCL domains.
Combination of DXA and BIS body composition measurements is highly correlated with physical function—an approach to improve muscle mass assessment Peer-reviewed

Kuchnia, A.J., Yamada, Y., Teigen, L., Krueger, D., Binkley, N., Schoeller, D.

Archives of Osteoporosis　13　(1)　97　2018/09

DOI： 10.1007/s11657-018-0508-7 　

ISSN： 1862-3522
Muscle thickness, echo intensity, and muscle cell mass as indicators in skeletal muscle evaluation of the older adults.

谷口匡史, 山田陽介, 市橋則明

大阪ガスグループ福祉財団調査・研究報告集　31　25‐29-29　2018/06
Publisher: 大阪ガスグループ福祉財団
Muscle glycogen depletion does not alter segmental extracellular and intracellular water distribution measured using bioimpedance spectroscopy. International-journal Peer-reviewed

Shiose K, Yamada Y, Motonaga K, Takahashi H

Journal of applied physiology (Bethesda, Md. : 1985)　124　(6)　1420-1425　2018/06

DOI： 10.1152/japplphysiol.00666.2017 　

ISSN： 8750-7587

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Although each gram of glycogen is well known to bind 2.7-4.0 g of water, no studies have been conducted on the effect of muscle glycogen depletion on body water distribution. We investigated changes in extracellular and intracellular water (ECW and ICW) distribution in each body segment in muscle glycogen-depletion and glycogen-recovery condition using segmental bioimpedance spectroscopy technique (BIS). Twelve male subjects consumed 7.0 g/kg body mass of indigestible (glycogen-depleted group) or digestible (glycogen-recovered group) carbohydrate for 24 h after a glycogen-depletion cycling exercise. Muscle glycogen content using 13C-magnetic resonance spectroscopy, blood hydration status, body composition, and ECW and ICW content of the arm, trunk, and leg using BIS were measured. Muscle glycogen content at the thigh muscles decreased immediately after exercise (glycogen-depleted group, 71.6 ± 12.1 to 25.5 ± 10.1 mmol/kg wet wt; glycogen-recovered group, 76.2 ± 16.4 to 28.1 ± 16.8 mmol/kg wet wt) and recovered in the glycogen-recovered group (72.7 ± 21.2 mmol/kg wet wt) but not in the glycogen-depleted group (33.2 ± 12.6 mmol/kg wet wt) 24 h postexercise. Fat-free mass decreased in the glycogen-depleted group ( P < 0.05) but not in the glycogen-recovered group 24 h postexercise. However, no changes were observed in ECW and ICW content at the leg in both groups. Our results suggested that glycogen depletion per se does not alter body water distribution as estimated via BIS. This information is valuable in assessing body composition using BIS in athletes who show variable glycogen status during training and recovery. NEW & NOTEWORTHY Segmental bioimpedance spectroscopy analysis reveals the effect of muscle glycogen depletion on body segmental water distribution in controlled conditions. Despite the significant difference in the muscle glycogen levels at the leg, no difference was observed in body resistance and the corresponding water content of the extracellular and intracellular compartments.
Effect of the Health Tourism weight loss programme on body composition and health outcomes in healthy and excess-weight adults Peer-reviewed

Hiroyuki Sagayama, Kayoko Shizuma, Makiko Toguchi, Hiroji Mizuhara, Yukiko Machida, Yosuke Yamada, Naoyuki Ebine, Yasuki Higaki, Hiroaki Tanaka

British Journal of Nutrition　119　(10)　1133-1141　2018/05/28
Publisher: Cambridge University Press
DOI： 10.1017/S0007114518000582 　

ISSN： 1475-2662 0007-1145
Sociodemographic and physical predictors of non-participation in community based physical checkup among older neighbors: a case-control study from the Kyoto-Kameoka longitudinal study, Japan. International-journal Peer-reviewed

Miwa Yamaguchi, Tsukasa Yoshida, Yosuke Yamada, Yuya Watanabe, Hinako Nanri, Keiichi Yokoyama, Heiwa Date, Motoko Miyake, Aya Itoi, Emi Yamagata, Taeko Masumoto, Yasuko Okayama, Yasuko Yoshinaka, Misaka Kimura

BMC public health　18　(1)　568-568　2018/05/02

DOI： 10.1186/s12889-018-5426-5 　

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BACKGROUND: It is difficult to obtain detailed information on non-participants in physical and health examination checkups in community-based epidemiological studies. We investigated the characteristics of non-participants in a physical and health examination checkup for older adults in a nested study from the Japanese Kyoto-Kameoka Longitudinal Study. METHODS: We approached a total of 4831 people aged ≥65 years in 10 randomly selected intervention regions. Participants responded to a mail-based population survey on needs in the sphere of daily life to encourage participation in a free face-to-face physical checkup examination; 1463 participants (706 men, 757 women) participated in the physical checkup. A multiple logistic regression model was performed to investigate the adjusted odds ratios (aOR) of non-participation based on sociodemographic status apart from psychological and physiological frailty as assessed by the validated Kihon Checklist. RESULTS: There was a significant, inverse relationship between non-participation and frequently spending time alone among individuals who lived with someone or other family structure (aOR = 0.53, standard error [SE] 0.08 in men, aOR = 0.66, SE 0.09 in women). Very elderly (over 80 years old) women, poorer health consciousness and current smoking in both sexes and poor self-rated health in men, were significantly related to higher non-participation rates. In both sexes, individuals who did not participate in community activities were significantly more likely to be non-participants than individuals who did (aOR = 1.94, SE 0.23 in men, aOR = 3.29, SE 0.39 in women). Having low IADL and physical functioning scores were also associated with higher rates of non-participation. CONCLUSION: Health consciousness and lack of community activity participation were predictors of non-participation in a physical checkup examination among older adults. In addition, lower IADL and physical functioning/strength were also predictors of non-participation. On the contrary, older inhabitants living with someone tended to participate in the physical checkup examination for social interchange when they were frequently alone in the household. This study suggests the importance of considering aging especially for women and poor sociodemographic background and physical frailty for both sexes so that older people can access health programs without difficulty. TRIAL REGISTRATION: UMIN000008105 . Registered 26 April 2012. Retrospectively registered.
Coping strategy and social support modify the association between perceived stress and C-reactive protein: a longitudinal study of healthy men and women. International-journal Peer-reviewed

Chisato Shimanoe, Megumi Hara, Yuichiro Nishida, Hinako Nanri, Yasuko Otsuka, Mikako Horita, Jun Yasukata, Nobuyuki Miyoshi, Yosuke Yamada, Yasuki Higaki, Keitaro Tanaka

Stress (Amsterdam, Netherlands)　21　(3)　237-246　2018/05

DOI： 10.1080/10253890.2018.1435638 　

ISSN： 1025-3890

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Inconsistent associations have been reported between perceived stress and C-reactive protein (CRP), a marker of systemic inflammation. We previously observed a male-specific inverse relationship between perceived stress and CRP in a cross-sectional study. In the present study, we examined the longitudinal association between changes in perceived stress and CRP, and further analyzed whether changes in coping strategies and social support modify this association. This study included 8454 participants in both a baseline survey and a follow-up survey 5 years later. Psychosocial measures (i.e. perceived stress, coping strategies, and social support) and CRP concentrations were measured by identical means in both surveys. Consistent with our previous findings, increased perceived stress was significantly associated with lower CRP in men (ptrend = .037), but not in women. Increased "emotional expression," a coping strategy, was also associated with lower CRP in women (ptrend = .024). Furthermore, interactions between perceived stress and a coping strategy (positive reappraisal) or social support on CRP were found in men (pinteraction = .007 and .038, respectively); the above inverse association between stress and CRP was not detected for participants with diminished positive reappraisal or social support. In conclusion, increases in perceived stress during a 5-year period were associated with decreases in CRP among healthy men, and the observed association was possibly modified by coping strategy or social support.
球種と肩肘の投球傷害との関係

平本真知子, 森原徹, 松井知之, 東善一, 瀬尾和弥, 宮崎哲哉, 渡邊裕也, 山田陽介, 来田宣幸, 盛房周平

日本臨床スポーツ医学会誌　26　(2)　230‐235-235　2018/04/30
Publisher:
ISSN： 1346-4159
Energy Deficit Required for Rapid Weight Loss in Elite Collegiate Wrestlers. International-journal Peer-reviewed

Emi Kondo, Hiroyuki Sagayama, Yosuke Yamada, Keisuke Shiose, Takuya Osawa, Keiko Motonaga, Shiori Ouchi, Akiko Kamei, Kohei Nakajima, Yasuki Higaki, Hiroaki Tanaka, Hideyuki Takahashi, Koji Okamura

Nutrients　10　(5)　2018/04/26

DOI： 10.3390/nu10050536 　

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To determine energy density for rapid weight loss (RWL) of weight-classified sports, eight male elite wrestlers were instructed to lose 6% of body mass (BM) within 53 h. Energy deficit during the RWL was calculated by subtracting total energy expenditure (TEE) determined using the doubly labeled water method (DLW) from energy intake (EI) assessed with diet records. It was also estimated from body composition change estimated with the four-component model (4C) and other conventional methods. BM decreased significantly by 4.7 ± 0.5 kg (6.4 ± 0.5%). Total body water loss was the major component of the BM loss (71.0 ± 7.6%). TEE was 9446 ± 1422 kcal, and EI was 2366 ± 1184 kcal during the RWL of 53-h; therefore, the energy deficit was 7080 ± 1525 kcal. Thus, energy density was 1507 ± 279 kcal/kg ∆BM during the RWL, comparable with values obtained using the 4C, three-component model, dual energy X-ray absorptiometry, and stable isotope dilution. Energy density for RWL of wrestlers is lower than that commonly used (7400 or 7700 kcal/kg ΔBM). Although RWL is not recommended, we propose that commonly practiced extreme energy restriction such as 7400 or 7700 kcal/kg ΔBM during RWL appears to be meaningless.
自立した高齢者における総エネルギー消費量および身体活動レベル

田中茂穂, 高田和子, 中江悟司, 山田陽介, 佐々木敏

日本栄養・食糧学会大会講演要旨集　72回　247-247　2018/04
Publisher: (公社)日本栄養・食糧学会
糖尿病患者の身体活動量の特徴と体組成、体格との関係日本人の食事摂取基準2020年版に向けて

宮澤伊都子, 森野勝太郎, 布施恵子, 近藤慶子, 大井彰子, 西田香, 栗原美香, 安原祥子, 中西直子, 西田優紀, 中江悟司, 山田陽介, 田中茂穂, 海老根直之, 佐々木敏, 勝川史憲, 佐々木雅也, 卯木智, 前川聡

糖尿病　61　(Suppl.1)　S-152　2018/04
Publisher: (一社)日本糖尿病学会
ISSN： 0021-437X

eISSN： 1881-588X
Seasonal changes in anthropometric, physiological, nutritional, and performance factors in collegiate rowers. International-journal Peer-reviewed

Kenji Kuzuhara, Kanako Katai, Tatsuya Hojo, Yoshihiko Fujisawa, Misaka Kimura, Yasuyoshi Yanagida, Yosuke Yamada, Junta Iguchi

Journal of strength and conditioning research　2018/03/06

DOI： 10.1519/JSC.0000000000002521 　

ISSN： 1064-8011

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Well-controlled seasonal distribution of training intensity appears to be an important variable for endurance athletes' success as competitors and/or for avoidance of overtraining. The aim of this study was to examine the interrelationships of training distribution, body composition, energy intake/expenditure, and rowing ergometer performance throughout the 2012-2013 season. In the present study of 15 collegiate male rowers, most of whom started rowing during their time at the university, we divided the 2012-2013 season (total 37 weeks) into 3 phases (off-season, December to mid-March, 16 weeks; pre-season, late March to April, 5 weeks; and in-season, May to August, 16 weeks) and analyzed the transition of 2000-m rowing ergometer time, training intensity/volume, body composition (body weight and body fat) and energy intake/expenditure in each phase. There were significant main effects of the training time by the intensities; 2000-m rowing ergometer time; energy expenditure; and protein, fat, and carbohydrate intake across the seasons (p < 0.05). Two findings were particularly important. First, on-water high-intensity training, especially for inexperienced rowers, may contribute to improvement of 2000-m rowing ergometer performance. Second, higher intake of carbohydrate, and to a lesser degree, protein, is necessary for optimal training adaptation (e.g., increase of muscle glycogen content), and results in better 2000-m performance on the rowing ergometer. Also, those findings may be beneficial to the coaches who are interested in designing the well-controlled seasonal training program, which is especially intended to improve the 2000-m rowing ergometer performance as well as avoidance of overtraining.
Caloric Restriction and Healthy Life Span: Frail Phenotype of Nonhuman Primates in the Wisconsin National Primate Research Center Caloric Restriction Study Peer-reviewed

Yosuke Yamada, Joseph W Kemnitz, Richard Weindruch, Rozalyn M Anderson, Dale A Schoeller, Ricki J. Colman

Journals of Gerontology - Series A Biological Sciences and Medical Sciences　73　(3)　273-278　2018/03/02
Publisher: Oxford University Press
DOI： 10.1093/gerona/glx059 　

ISSN： 1758-535X 1079-5006
5年間の精神ストレスとCRPの関連は、対処行動や社会的支援の変化により異なる

島ノ江千里, 原めぐみ, 西田裕一郎, 南里妃名子, 安方惇, 三好信行, 山田陽介, 桧垣靖樹, 田中恵太郎

日本衛生学雑誌　73　(Suppl.)　S228-S228　2018/03
Publisher: (一社)日本衛生学会
ISSN： 0021-5082

eISSN： 1882-6482
Muscle size-strength relationship including ultrasonographic echo intensity and voluntary activation level of a muscle group Peer-reviewed

Ryota Akagi, Momoka Suzuki, Emi Kawaguchi, Naokazu Miyamoto, Yosuke Yamada, Ryoichi Ema

Archives of Gerontology and Geriatrics　75　185-190　2018/03/01
Publisher: Elsevier Ireland Ltd
DOI： 10.1016/j.archger.2017.12.012 　

ISSN： 1872-6976 0167-4943
Effect of physical activity, weight loss experience, and history of exercise habits on bone mineral density among female college students

糸井亜弥, 大槻美貴, 山田陽介

日本スポーツ栄養研究誌　11　70‐78-78　2018/01/20
Publisher: 日本スポーツ栄養研究会
ISSN： 2188-8922
Association between the Frequency of Protein-Rich Food Intakes and Kihon-Checklist Frailty Indices in Older Japanese Adults: The Kyoto-Kameoka Study. International-journal Peer-reviewed

Miwa Yamaguchi, Yosuke Yamada, Hinako Nanri, Yoshizu Nozawa, Aya Itoi, Eiichi Yoshimura, Yuya Watanabe, Tsukasa Yoshida, Keiichi Yokoyama, Chiho Goto, Kazuko Ishikawa-Takata, Hisamine Kobayashi, Misaka Kimura

Nutrients　10　(1)　2018/01/13

DOI： 10.3390/nu10010084 　

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We aimed to investigate whether frequencies of protein-rich food intake were associated with frailty among older Japanese adults. A cross-sectional study was conducted in 2011 among 3843 men and 4331 women in a population-based cohort of Kameoka city, Kyoto Prefecture, Japan. Frailty was assessed by the weighted score based on the 25-item Kihon-Checklist. The frequency of protein-rich food intake was examined as "seafood", "meat", "dairy products", "eggs", and "soy products". The outcome of frailty was analyzed with a multiple logistic regression model using the frequency of protein-rich food intake. When compared to the first quartile, it was observed that there was a significant association between the lower adjusted prevalence ratio (PR) for frailty and the frequency of seafood intake in the fourth quartile among men (PR 0.64, 95% confidence interval (CI), 0.42, 0.99) and from the second quartile to the third quartile among women (PR 0.61, 95% CI, 0.43, 0.85; PR 0.64, 95% CI, 0.46, 0.91). The frequency of dairy products intake in the third quartile among women was significantly associated with a lower PR for frailty (p-value = 0.013). Our findings suggest that the consumption of seafood and dairy products may help older adults in maintaining their independence.
Could bioelectric impedance spectroscopy (BIS) measured appendicular intracellular water serve as a lean mass measurement in sarcopenia definitions? A pilot study

Siglinsky, E., Buehring, B., Krueger, D., Binkley, N., Yamada, Y.

Osteoporosis International　29　(7)　2018

DOI： 10.1007/s00198-018-4475-z 　
Comparison of muscle/lean mass measurement methods: correlation with functional and biochemical testing

Buehring, B., Siglinsky, E., Krueger, D., Evans, W., Hellerstein, M., Yamada, Y., Binkley, N.

Osteoporosis International　29　(3)　2018

DOI： 10.1007/s00198-017-4315-6 　
糖尿病患者における総エネルギー消費量を用いた半秤量式食事記録と食物摂取頻度調査の妥当性検討

西田香, 大井彰子, 栗原美香, 安原祥子, 中西直子, 佐々木雅也, 布施恵子, 森野勝太郎, 卯木智, 前川聡, 近藤慶子, 西田優紀, 中江悟司, 山田陽介, 田中茂穂, 海老根直之, 佐々木敏, 勝川史憲

日本病態栄養学会誌　21　(Suppl.)　S-99　2018/01
Publisher: (一社)日本病態栄養学会
ISSN： 1345-8167
運動療法と栄養療法糖尿病患者におけるエネルギー消費量及び活動量

栗原美香, 西田香, 大井彰子, 安原祥子, 中西直子, 布施恵子, 森野勝太郎, 卯木智, 前川聡, 近藤慶子, 西田優紀, 中江悟司, 山田陽介, 田中茂穂, 海老根直之, 佐々木敏, 勝川史憲, 佐々木雅也

日本静脈経腸栄養学会雑誌　33　(Suppl.)　260-260　2018/01
Publisher: (株)ジェフコーポレーション
ISSN： 2189-0161

eISSN： 2189-017X
新たな骨格筋・サルコペニア評価法の確立

赤木亮太, 江間諒一, 山田陽介

特別教育・研究報告集　403-406　2018
Publisher: 芝浦工業大学連携推進部
ISSN： 2185-7326
Relationship between pitch type and shoulder/elbow injuries

平本真知子, 森原徹, 松井知之, 東善一, 瀬尾和弥, 宮崎哲哉, 渡邊裕也, 山田陽介, 来田宣幸, 盛房周平

日本臨床スポーツ医学会誌　26　(2)　230-235　2018
Publisher: 日本臨床スポーツ医学会
ISSN： 1346-4159
The effect of exercise intervention and caloric restricted low‐ or high‐carbohydrate diet with high protein on body composition in a short‐term weight loss program

下山寛之, 下山寛之, 渡口槙子, 安方惇, 山崎郁美, 嶋田康平, 廣田貴也, 山田陽介, 山田陽介, 海老根直之, 布目寛幸, 清永明, 清永明, 桧垣靖樹, 桧垣靖樹, 田中宏暁, 田中宏暁

日本スポーツ栄養研究誌　11　16‐24-24　2018/01
Publisher: 日本スポーツ栄養研究会
ISSN： 2188-8922
Perceived Stress, Depressive Symptoms, and Oxidative DNA Damage. International-journal Peer-reviewed

Chisato Shimanoe, Megumi Hara, Yuichiro Nishida, Hinako Nanri, Mikako Horita, Yosuke Yamada, Yun-Shan Li, Hiroshi Kasai, Kazuaki Kawai, Yasuki Higaki, Keitaro Tanaka

Psychosomatic medicine　80　(1)　28-33　2018/01

DOI： 10.1097/PSY.0000000000000513 　

ISSN： 0033-3174

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OBJECTIVE: Psychosocial stress may influence the risk of disease through its association with oxidative DNA damage. We examined whether perceived stress and depressive symptoms were associated with urinary excretion of 8-hydroxydeoxyguanosine (8-OHdG), with mutual interaction on 8-OHdG. METHODS: This cross-sectional study included 6517 individuals aged 45 to 74 years who participated, between 2010 and 2012, in a follow-up survey of an ongoing cohort study. Perceived stress during the past year was measured using a self-report questionnaire. Depressive symptoms were evaluated using the Zung Self-Rating Depression Scale. Urinary 8-OHdG concentrations were measured using a column switching high-pressure liquid chromatography system coupled to an electrochemical detector. RESULTS: Higher perceived stress was significantly associated with higher 8-OHdG (2.1% increase per one-category increase of stress; ptrend = .025), even after adjusting for sex, age, supplement use, psychosocial factors, psychotropic medication use, smoking, and body mass index. This association was modestly attenuated after further adjustment for physical activity, suggesting possible mediation or confounding by this factor. Depressive symptoms were not significantly associated with 8-OHdG. No significant interaction was detected between perceived stress and depressive symptoms on 8-OHdG. CONCLUSIONS: In a general Japanese population, we found a weak positive association between perceived stress and urinary excretion of 8-OHdG, whereas no association was observed between depressive symptoms and 8-OHdG. Further studies are needed to examine whether the association between perceived stress and 8-OHdG is modified by depressive symptoms.
Light rhythmic exercise with dietary milk fat globule membrane improves physical fitness in an elderly Japanese population: A double-blind randomized placebo-controlled trial Peer-reviewed

Yasuko Yoshinaka, Satoko Soga, Noriyasu Ota, Keiichi Yokoyama, Yosuke Yamada, Misaka Kimura

Bioscience, Biotechnology and Biochemistry　82　(4)　677-682　2018
Publisher: Japan Society for Bioscience Biotechnology and Agrochemistry
DOI： 10.1080/09168451.2017.1412248 　

ISSN： 1347-6947 0916-8451
Comprehensive geriatric intervention program with and without weekly class-style exercise: research protocol of a cluster randomized controlled trial in Kyoto-Kameoka Study. International-journal Peer-reviewed

Yuya Watanabe, Yosuke Yamada, Keiichi Yokoyama, Tsukasa Yoshida, Yasuko Yoshinaka, Mie Yoshimoto, Yoko Tanaka, Aya Itoi, Emi Yamagata, Naoyuki Ebine, Kazuko Ishikawa-Takata, Misaka Kimura

Clinical interventions in aging　13　1019-1033　2018

DOI： 10.2147/CIA.S151427 　

ISSN： 1176-9092

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Objective: The number of long-term care (LTC) users and the associated expenditures in Japan are increasing dramatically. The national government recommends LTC prevention through activation of communities. However, there is no clear evidence of the effect of population-based comprehensive geriatric intervention program (CGIP) for restraints of LTC users and the associated expenditures in the future. The aims of the current paper are to describe the study protocol and progress of a cluster randomized controlled trial (RCT) with a CGIP in Kameoka City. Methods: The cluster RCT involved random allocation of regions as intervention (n=4,859) and nonintervention (n=7,195). Participants were elderly persons aged ≥65 years without LTC certification who had responded to a mailing survey. The residents living in intervention regions were invited to a physical check-up, and 1,463 people participated (30.3%). These individuals were invited to the CGIP, and 526 accepted. The CGIP comprised instructions on: 1) low-load resistance training using bodyweight, ankle weights, and elastic bands; 2) increasing daily physical activity; 3) oral motor exercise and care; and 4) a well-balanced diet based on a program from Ministry of Health, Labour and Welfare. We allocated the intervention regions randomly into home-based self-care program alone (HB group, 5 regions, n=275) and home-based program+weekly class-style session (CS group, 5 regions, n=251). We evaluated the effects of the CGIP at 12 weeks and at 12 or 15 months on physical function, and are conducting follow-up data collection for an indefinite period regarding LTC certification, medical costs, and mortality. Results and discussion: The study was launched with good response rates in each phase. Participants of both groups significantly increased their step counts by ~1,000 per day from the baseline during the CGIP. This RCT will provide valuable information and evidence about effectiveness of a community-based CGIP.
Association between echo intensity and attenuation of skeletal muscle in young and older adults: A comparison between ultrasonography and computed tomography Peer-reviewed

Watanabe, Y., Ikenaga, M., Yoshimura, E., Yamada, Y., Kimura, M.

Clinical Interventions in Aging　13　1871-1878　2018

DOI： 10.2147/CIA.S173372 　

ISSN： 1176-9092
Muscle mass, quality, and composition changes during atrophy and sarcopenia Peer-reviewed

Yamada, Y.

Advances in Experimental Medicine and Biology　1088　47-72　2018

DOI： 10.1007/978-981-13-1435-3_3 　

ISSN： 0065-2598
The Association between Self-Reported Difficulty of Food Access and Nutrient Intake among Middle-Aged and Older Residents in a Rural Area of Japan Peer-reviewed

Miwa Yamaguchi, Katsuya Takahashi, Ryosuke Kikushima, Megumi Ohashi, Maria Ikegawa, Tetsuro Yakushiji, Yosuke Yamada

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY　64　(6)　473-482　2018

DOI： 10.3177/jnsv.64.473 　

ISSN： 0301-4800

eISSN： 1881-7742
Frequency of Fruit and Vegetable Consumption and the Oral Health-Related Quality of Life among Japanese Elderly: A Cross-Sectional Study from the Kyoto-Kameoka Study Peer-reviewed

Hinako Nanri, Yosuke Yamada, Aya Itoi, Emi Yamagata, Yuya Watanabe, Tsukasa Yoshida, Motoko Miyake, Heiwa Date, Kazuko Ishikawa-Takata, Mitsuyoshi Yoshida, Takeshi Kikutani, Misaka Kimura

NUTRIENTS　9　(12)　2017/12

DOI： 10.3390/nu9121362 　

ISSN： 2072-6643
Validity of predictive equations for resting metabolic rate in healthy older adults Peer-reviewed

Aya Itoi, Yosuke Yamada, Keiichi Yokoyama, Tetsuji Adachi, Misaka Kimura

Clinical Nutrition ESPEN　22　64-70　2017/12/01
Publisher: Elsevier Ltd
DOI： 10.1016/j.clnesp.2017.08.010 　

ISSN： 2405-4577
Characteristics of range of motion among women pro baseball players: A comparison with university men Peer-reviewed

Machiko Hiramoto, Toru Morihara, Tomoyuki Matsui, Yoshikazu Azuma, Kazuya Seo, Tetsuya Miyazaki, Toshiaki Eto, Yuya Watanabe, Takeshi Sukenari, Yosuke Yamada, Shuhei Morifusa, Noriyuki Kida

Advances in Physical Education　7　(04)　418-424　2017/11
Publisher: Scientific Research Publishing, Inc.
DOI： 10.4236/ape.2017.74035 　

ISSN： 2164-0386

eISSN： 2164-0408
Total energy expenditure of 10-to 12-year-old Japanese children measured using the doubly labeled water method Peer-reviewed

Keisuke Komura, Satoshi Nakae, Kazufumi Hirakawa, Naoyuki Ebine, Kazuhiro Suzuki, Haruo Ozawa, Yosuke Yamada, Misaka Kimura, Kojiro Ishii

NUTRITION & METABOLISM　14　70　2017/11

DOI： 10.1186/s12986-017-0226-y 　

ISSN： 1743-7075
質問紙によるフレイル判定と超音波法を用いた下肢骨格筋の量的・質的指標の関連

渡邊裕也, 吉田司, 山田陽介, 横山慶一, 山縣恵美, 三宅基子, 吉中康子, 岡山寧子, 木村みさか

日本サルコペニア・フレイル学会雑誌　1　(2)　151-151　2017/10
Publisher: (一社)日本サルコペニア・フレイル学会
ISSN： 2433-1805
地域在住高齢者における緑茶の摂取頻度とフレイルとの関連 Kyoto-Kameoka Study

南里妃名子, 山田陽介, 山口美輪, 吉田司, 渡邊裕也, 山縣恵美, 木村みさか

日本サルコペニア・フレイル学会雑誌　1　(2)　126-126　2017/10
Publisher: (一社)日本サルコペニア・フレイル学会
ISSN： 2433-1805
地域在住高齢者における魚介類の摂取頻度とフレイルとの関連 Kyoto-Kameoka Study

山口美輪, 山田陽介, 南里妃名子, 野沢与志津, 吉田司, 渡邊裕也, 山縣恵美, 小林久峰, 木村みさか

日本サルコペニア・フレイル学会雑誌　1　(2)　127-127　2017/10
Publisher: (一社)日本サルコペニア・フレイル学会
ISSN： 2433-1805
Energy Requirement Assessment in Japanese Table Tennis Players Using the Doubly Labeled Water Method Peer-reviewed

Hiroyuki Sagayama, Genki Hamaguchi, Makiko Toguchi, Mamiko Ichikawa, Yosuke Yamada, Naoyuki Ebine, Yasuki Higaki, Hiroaki Tanaka

INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM　27　(5)　421-428　2017/10

DOI： 10.1123/ijsnem.2017-0022 　

ISSN： 1526-484X

eISSN： 1543-2742
Increase in echo intensity and extracellular-to-intracellular water ratio is independently associated with muscle weakness in elderly women Peer-reviewed

Masashi Taniguchi, Yosuke Yamada, Yoshihiro Fukumoto, Shinichiro Sawano, Seigo Minami, Tome Ikezoe, Yuya Watanabe, Misaka Kimura, Noriaki Ichihashi

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY　117　(10)　2001-2007　2017/10

DOI： 10.1007/s00421-017-3686-x 　

ISSN： 1439-6319

eISSN： 1439-6327
Surveying predictors of late-life longitudinal change in daily activity energy expenditure Peer-reviewed

Vincenzo Valiani, Sandrine Sourdet, Dale A. Schoeller, Dawn C. Mackey, Douglas C. Bauer, Nancy W. Glynn, Yosuke Yamada, Tamara B. Harris, Todd M. Manini

PLOS ONE　12　(10)　e0186289　2017/10

DOI： 10.1371/journal.pone.0186289 　

ISSN： 1932-6203
地域高齢者を対象とした体力科学的アプローチによる認知症とサルコペニア予防の縦断研究―福岡那珂川研究―車の運転の有無と脳機能の関係

古瀬裕次郎, 池永昌弘, 山田陽介, 武田典子, 森村和浩, 三好伸幸, 栗山緑, 町田由紀子, 寺田久子, 合馬慎二, 坪井義夫, 山田達夫, 山田達夫, 木村みさか, 清永明, 清永明, 田中宏暁, 檜垣靖樹

月刊臨床と研究　94　(9)　1195‐1196　2017/09/20

ISSN： 0021-4965
糖尿病の運動の効果についての総括糖尿病患者におけるエネルギー消費量の実態

大井彰子, 西田香, 栗原美香, 安原祥子, 中西直子, 佐々木雅也, 布施恵子, 森野勝太郎, 卯木智, 前川聡, 近藤慶子, 西田優紀, 中江悟司, 山田陽介, 田中茂穂, 海老根直之, 佐々木敏, 勝川史憲

日本臨床運動療法学会雑誌　19　(1)　62-62　2017/09
Publisher: (NPO)日本臨床運動療法学会
PHYSICAL CHARACTERISTICS AND PERFORMANCE OF JAPANESE TOP-LEVEL AMERICAN FOOTBALL PLAYERS Peer-reviewed

Daichi Yamashita, Masaki Asakura, Yoshihiko Ito, Shinzo Yamada, Yosuke Yamada

JOURNAL OF STRENGTH AND CONDITIONING RESEARCH　31　(9)　2455-2461　2017/09

DOI： 10.1519/JSC.0000000000001714 　

ISSN： 1064-8011

eISSN： 1533-4287
Electrical Properties Assessed by Bioelectrical Impedance Spectroscopy as Biomarkers of Age-related Loss of Skeletal Muscle Quantity and Quality Peer-reviewed

Yosuke Yamada, Bjoern Buehring, Diane Krueger, Rozalyn M. Anderson, Dale A. Schoeller, Neil Binkley

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES　72　(9)　1180-1186　2017/09

DOI： 10.1093/gerona/glw225 　

ISSN： 1079-5006

eISSN： 1758-535X
Effect of exercise timing on elevated postprandial glucose levels Peer-reviewed

Yoichi Hatamoto, Ryoma Goya, Yosuke Yamada, Eichi Yoshimura, Sena Nishimura, Yasuki Higaki, Hiroaki Tanaka

JOURNAL OF APPLIED PHYSIOLOGY　123　(2)　278-284　2017/08

DOI： 10.1152/japplphysiol.00608.2016 　

ISSN： 8750-7587

eISSN： 1522-1601
Prevalence of Frailty Assessed by Fried and Kihon Checklist Indexes in a Prospective Cohort Study: Design and Demographics of the Kyoto-Kameoka Longitudinal Study Peer-reviewed

Yosuke Yamada, Hinako Nanri, Yuya Watanabe, Tsukasa Yoshida, Keiichi Yokoyama, Aya Itoi, Heiwa Date, Miwa Yamaguchi, Motoko Miyake, Emi Yamagata, Hajime Tamiya, Miho Nishimura, Mami Fujibayashi, Naoyuki Ebine, Mitsuyoshi Yoshida, Takeshi Kikutani, Eiichi Yoshimura, Kazuko Ishikawa-Takata, Minoru Yamada, Tomoki Nakaya, Yasuko Yoshinaka, Yoshinori Fujiwara, Hidenori Arai, Misaka Kimura

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION　18　(8)　733.e7-733.e15　2017/08

DOI： 10.1016/j.jamda.2017.02.022 　

ISSN： 1525-8610

eISSN： 1538-9375
筋力を決定する筋の量的/質的要因の解明―新たな筋力トレーニング法の創出に向けて―

赤木亮太, 江間諒一, 江間諒一, 宮本直和, 山田陽介

芝浦工業大学特別教育・研究報告集(CD-ROM)　2016　261‐264　2017/07/31

ISSN： 2185-7326
Developing and validating an age-independent equation using multi-frequency bioelectrical impedance analysis for estimation of appendicular skeletal muscle mass and establishing a cutoff for sarcopenia Peer-reviewed

Yosuke Yamada, Miyuki Nishizawa, Tomoka Uchiyama, Yasuhiro Kasahara, Mikio Shindo, Motohiko Miyachi, Shigeho Tanaka

International Journal of Environmental Research and Public Health　14　(7)　2017/07/19
Publisher: MDPI AG
DOI： 10.3390/ijerph14070809 　

ISSN： 1660-4601 1661-7827
Developing and Validating an Age-Independent Equation Using Multi-Frequency Bioelectrical Impedance Analysis for Estimation of Appendicular Skeletal Muscle Mass and Establishing a Cutoff for Sarcopenia Peer-reviewed

Yosuke Yamada, Miyuki Nishizawa, Tomoka Uchiyama, Yasuhiro Kasahara, Mikio Shindo, Motohiko Miyachi, Shigeho Tanaka

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH　14　(7)　E809　2017/07

DOI： 10.3390/ijerph14070809 　

ISSN： 1660-4601
サルコペニアを知ろう!サルコペニアの評価法と定義―一般的概念,および消化器外科領域に占める重要性―

山田陽介

消化器外科　40　(7)　1009‐1024　2017/06/10

ISSN： 0387-2645
包括的な老化尺度「迅速老年医学評価(Rapid Geriatric Assessment)」の邦訳とその妥当性

山田陽介, 中江悟司, 西田優紀, 渡邊裕也, 松坂雄亮, 糸井亜弥, 山田実, 佐々木敏, 平野浩彦, 木村みさか, 田中茂穂, 勝川史憲

日本抗加齢医学会総会プログラム・抄録集　17回　178-178　2017/06
Publisher: (一社)日本抗加齢医学会
施設入所高齢者における移乗動作の自立度と移動様式が身体活動量と心身の健康度に及ぼす影響 Peer-reviewed

西田優紀, 中江悟司, 山田陽介, 山口美輪, 近藤衣美, 白土裕之, 平野浩彦, 佐々木敏, 田中茂穂, 勝川史憲

日本老年医学会雑誌　54　(Suppl.)　168-168　2017/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
Fitness Age Score and the risk of long-term care insurance certification—KYOTO-Kameoka Study Peer-reviewed

Tsukasa Yoshida, Misaka Kimura, Yosuke Yamada, Keiichi Yokoyama, Tatsuro Ishihara, Yasuko Yoshinaka, Aya Itoi, Yuya Watanabe, Noriyuki Kida, Teruo Nomura

Open Journal of Epidemiology　7　(02)　190-200　2017/05
Publisher: Scientific Research Publishing, Inc.
DOI： 10.4236/ojepi.2017.72016 　

ISSN： 2165-7459

eISSN： 2165-7467

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ABSTRACT Long-Term Care Insurance System has been introduced to provide appropriate care for the elderly who needs nursing care in Japan. Physical function is one of most important function for the elderly to live independently. A previous study had established a Fitness Age Score (FAS) based on a theory for biomarker of aging. This study clarified whether the FAS could be used to predict the need for certification of long-term care (CLTC) in independent elderly people. We included 939 independent, community-dwelling-elderly (average age, 74.4 years) whose physical function was measured and for whom the CLTC was tracked for 24 months. The FAS comprised five physical fitness items: Walking time, grip strength, one-leg standing, vertical jump, and functional reach test. Based on the FAS, we calculated the odds ratio (OR) for the CLTC. Receiver operating characteristic (ROC) curves and the area under the curve (AUC) was used for further analysis. We also used the Youden Index (YI), minimum distance method (MD), and two-graph ROC method (TG) to calculate cutoff values (CVs) for screening. We divided subjects into the low and high physical fitness group with CVs. We developed cumulative CLTC curves using the Kaplan-Meier method. Sixteen people could not be tracked for the full 24 months. The measurement of FAS was completed for 798 people, of whom 28 became CLTC. The measurement of FAS was not completed for 125 people, of whom 21 became CLTC. The CLTC OR for people with incomplete FAS was 5.553. The AUC was 0.72 (p < 0.001). The CVs for the FAS were -0.29 for YI (sensitivity, 92.9% and specificity, 40.4%), -1.23 for MD (57.1% and 73.4%), and -0.81 for TG (60.7% and 60.9%). The cumulative CLTC curves according to CVs all showed significant differences (p = 0.000 - 0.020). In conclusion, the FAS can be used to predict CLTC. KEYWORDS Elderly, Physical Function, Long-Term Care, Screening, Fitness Age Score (FAS)
骨格筋超音波画像から算出する筋輝度を用いた骨格筋の質的評価法―現場で実践可能な筋肉組成評価法の確立を目指して―

渡邊裕也, 池永昌弘, 山田陽介

若手研究者のための健康科学研究助成成果報告書　32　(32)　114‐120-120　2017/04/30
Publisher:
Energy Requirement Assessment and Water Turnover in Japanese College Wrestlers Using the Doubly Labeled Water Method Peer-reviewed

Hiroyuki Sagayama, Emi Kondo, Keisuke Shiose, Yosuke Yamada, Keiko Motonaga, Shiori Ouchi, Akiko Kamei, Takuya Osawa, Kohei Nakajima, Hideyuki Takahashi, Yasuki Higaki, Hiroaki Tanaka

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY　63　(2)　141-147　2017/04

DOI： 10.3177/jnsv.63.141 　

ISSN： 0301-4800

eISSN： 1881-7742
Relationship between Cognitive Function by CPS and Physical Fitness in Community-dwelling Elderly Kyoto-KAMEOKA Study

吉田司, 木村みさか, 山田陽介, 来田宜幸, 野村照夫

京都学園大学健康医療学部紀要　(2)　35-40　2017/03/28

DOI： 10.20558/00001189 　
Relationship between the amount of physical activity and fitness in preschool children―Evaluation of the necessary number of steps, physical activity level, and du‐ration of physical activity by intensity―

青木好子, 金子眞理, 磯野眞紀子, 渡邊裕也, 山田陽介, 木村みさか

ウォーキング研究　(20)　79‐87　2017/03/23
地域在住自立高齢者を対象にした体力測定会への参加希望者における閉じこもりリスクと孤独感との関連

山縣恵美, 渡邊裕也, 山田陽介, 續田尚美, 杉原百合子, 小松光代, 木村みさか, 井上恒男, 亀岡スタディグループ

同志社看護　2　7-18　2017/03
Publisher: 同志社女子大学看護学会
ISSN： 2424-0400
The Extracellular to Intracellular Water Ratio in Upper Legs is Negatively Associated With Skeletal Muscle Strength and Gait Speed in Older People Peer-reviewed

Yosuke Yamada, Tsukasa Yoshidaz, Keiichi Yokoyama, Yuya Watanabe, Motoko Miyake, Emi Yamagata, Minoru Yamada, Misaka Kimura

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES　72　(3)　293-298　2017/03

DOI： 10.1093/gerona/glw125 　

ISSN： 1079-5006

eISSN： 1758-535X
Differences in frailty prevalence between evaluating methods in 1,379 community‐dwelling older adults―Kyoto‐KAMEOKA study―

吉田司, 木村みさか, 渡邊裕也, 三宅基子, 横山慶一, 吉中康子, 海老根直之, 菊谷武, 吉田光由, 高田和子, 山田実, 山田陽介, 来田宣幸, 野村照夫

健康支援　19　(1)　9‐18-18　2017/02/01
Publisher: 日本健康支援学会
ISSN： 1345-0174
地域在住高齢者が安全で手軽に実践できるレジスタンスエクササイズ

渡邊裕也, 山田陽介, 木村みさか

体力科学　66　(1)　23-23　2017
Publisher: 一般社団法人日本体力医学会
DOI： 10.7600/jspfsm.66.23 　
地域在住自立高齢者を対象にした体力測定会への参加希望者における閉じこもりリスクと孤独感との関連

山縣恵美, 渡邊裕也, 山田陽介, 續田尚美, 杉原百合子, 小松光代, 木村みさか, 井上恒男, 亀岡スタディグループ

同志社女子大学総合文化研究所紀要　2　43664　2017
Circadian variation of extracellular and intracellular resistance of the leg, arm, and trunk in healthy humans: A segmental bioimpedance spectroscopy study Peer-reviewed

Shiose, K., Yamada, Y., Motonaga, K., Takahashi, H.

Biomedical Physics and Engineering Express　3　(6)　2017

DOI： 10.1088/2057-1976/aa87c0 　
Effects of a 12-week, short-interval, intermittent, low-intensity, slow-jogging program on skeletal muscle, fat infiltration, and fitness in older adults: randomized controlled trial Peer-reviewed

Masahiro Ikenaga, Yosuke Yamada, Yujiro Kose, Kazuhiro Morimura, Yasuki Higaki, Akira Kiyonaga, Hiroaki Tanaka

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY　117　(1)　7-15　2017/01

DOI： 10.1007/s00421-016-3493-9 　

ISSN： 1439-6319

eISSN： 1439-6327
フレイルの予防とウォーキングフレイルにおけるサルコペニアと歩行機能

山田陽介

理学療法(東京)　33　(12)　1073‐1084　2016/12/28

ISSN： 0910-0059
Association between rapid force production by the plantar flexors and balance performance in elderly men and women Peer-reviewed

Ryoichi Ema, Megumi Saito, Shunsuke Ohki, Hirokazu Takayama, Yosuke Yamada, Ryota Akagi

AGE　38　(5-6)　475-483　2016/12

DOI： 10.1007/s11357-016-9949-3 　

ISSN： 0161-9152

eISSN： 1574-4647
Timed Up and Go test, atrophy of medial temporal areas and cognitive functions in community-dwelling older adults with normal cognition and mild cognitive impairment Peer-reviewed

Yujiro Kose, Masahiro Ikenaga, Yosuke Yamada, Kazuhiro Morimura, Noriko Takeda, Shinji Ouma, Yoshio Tsuboi, Tatsuo Yamada, Misaka Kimura, Akira Kiyonaga, Yasuki Higaki, Hiroaki Tanaka

EXPERIMENTAL GERONTOLOGY　85　81-87　2016/12

DOI： 10.1016/j.exger.2016.09.019 　

ISSN： 0531-5565

eISSN： 1873-6815
レスリング選手の急速減量と回復食摂取が身体組成に及ぼす影響 Peer-reviewed

近藤衣美, 塩瀬圭佑, 元永恵子, 大澤拓也, 下山寛之, 山田陽介, 大内志織, 亀井明子, 中嶋耕平, 和田貴広, 西口茂樹, 檜垣靖樹, 田中宏暁, 高橋英幸

Sports Science in Elite Athlete Support　1　(特別号)　16-16　2016/11
Publisher: (独)日本スポーツ振興センター国立スポーツ科学センター
ISSN： 2432-2091

eISSN： 2432-2105
レスリング選手の試合に向けた急速減量後の回復食の摂取状況 Peer-reviewed

近藤衣美, 山下大地, 西牧未央, 元永恵子, 山田陽介, 藤山光太郎, 中嶋耕平, 亀井明子

Sports Science in Elite Athlete Support　1　(特別号)　17-17　2016/11
Publisher: (独)日本スポーツ振興センター国立スポーツ科学センター
ISSN： 2432-2091

eISSN： 2432-2105
Intensity-specific effect of physical activity on urinary levels of 8-hydroxydeoxyguanosine in middle-aged Japanese Peer-reviewed

Megumi Hara, Yuichiro Nishida, Chisato Shimanoe, Yasuko Otsuka, Hinako Nanri, Jun Yasukata, Nobuyuki Miyoshi, Yosuke Yamada, Mikako Horita, Kazuaki Kawai, Yun-Shan Li, Jun Kasai, Hiroshi Kasai, Yasuki Higaki, Keitaro Tanaka

CANCER SCIENCE　107　(11)　1653-1659　2016/11

DOI： 10.1111/cas.13070 　

ISSN： 1347-9032

eISSN： 1349-7006
閉じこもり高齢者の各居住地区で行われる体力測定会への参加に影響する要因

山縣恵美, 渡邊裕也, 木村みさか, 山田陽介, 桝本妙子, 糸井亜弥, 三宅基子, 杉原百合子, 小松光代, 岡山寧子

日本公衆衛生学会総会抄録集　75回　642-642　2016/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
地域高齢者における身体活動量とフレイル亀岡スタディ活動量調査参加者での検討

木村みさか, 吉田司, 山田陽介, 渡邊裕也, 山縣恵美, 糸井亜弥, 三宅基子, 岡山寧子, 桝本妙子, 吉中康子

日本公衆衛生学会総会抄録集　75回　642-642　2016/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
Comparability of two representative devices for bioelectrical impedance data acquisition Peer-reviewed

Minoru Yamada, Yosuke Yamada, Hidenori Arai

GERIATRICS & GERONTOLOGY INTERNATIONAL　16　(9)　1087-1088　2016/09

DOI： 10.1111/ggi.12647 　

ISSN： 1444-1586

eISSN： 1447-0594
Children's Amount of Physical Activity According to Their Physical Activity Level : A Study Using the Doubly Labeled Water Method and An Accelerometer

香村恵介, 中江悟司, 平川和文, 海老根直之, 鈴木和弘, 小澤治夫, 山田陽介, 木村みさか, 石井好二郎

日本未病システム学会雑誌 = The journal of Japan Mibyo System Association　22　(2)　67-71　2016/08
Publisher: 日本未病システム学会
ISSN： 1347-5541
地域高齢者の閉じこもりと孤独感との関連

山縣恵美, 小松光代, 木村みさか, 山田陽介, 桝本妙子, 續田尚美, 杉原百合子, 岡山寧子

日本看護研究学会雑誌　39　(3)　296-296　2016/07
Publisher: (一社)日本看護研究学会
ISSN： 0285-9262

eISSN： 2189-6100
The relationship among the physical function, the performance and the sports injuries in women's professional baseball players

平本真知子, 森原徹, 松井知之, 東善一, 瀬尾和弥, 宮崎哲哉, 三浦雄一郎, 渡邊裕也, 山田陽介, 来田宣幸, 盛房周平

京都滋賀体育学研究 = Kyoto and Shiga journal of physical education, health and sport sciences　32　3-14　2016/07
Publisher: 京都滋賀体育学会
ISSN： 2187-7866
Segmental extracellular and intracellular water distribution and muscle glycogen after 72-h carbohydrate loading using spectroscopic techniques Peer-reviewed

Keisuke Shiose, Yosuke Yamada, Keiko Motonaga, Hiroyuki Sagayama, Yasuki Higaki, Hiroaki Tanaka, Hideyuki Takahashi

JOURNAL OF APPLIED PHYSIOLOGY　121　(1)　205-211　2016/07

DOI： 10.1152/japplphysiol.00126.2016 　

ISSN： 8750-7587

eISSN： 1522-1601
The Effect of Different Exercise Timing on Lowering Postprandial Glucose Elevation.―Is Interrupting Exercise Throughout the Day Effectiveness in Glycemic Control?―

畑本陽一, 田中宏暁, 山田陽介, 吉村英一

デサントスポーツ科学　37　66‐73-73　2016/06/03
Publisher: 石本記念デサントスポーツ科学振興財団事務局
ISSN： 0285-5739
Dilution space ratio of H-2 and O-18 of doubly labeled water method in humans Peer-reviewed

Hiroyuki Sagayama, Yosuke Yamada, Natalie M. Racine, Timothy C. Shriver, Dale A. Schoeller

JOURNAL OF APPLIED PHYSIOLOGY　120　(11)　1349-1354　2016/06

DOI： 10.1152/japplphysiol.01037.2015 　

ISSN： 8750-7587

eISSN： 1522-1601
Erratum to: Calculation of total energy expenditure in publications on physical activity energy by Yamada et al. in 2009 and 2013 Peer-reviewed

Yosuke Yamada, Keiichi Yokoyama, Risa Noriyasu, Tomoaki Osaki, Tetsuji Adachi, Aya Itoi, Yoshihiko Naito, Taketoshi Morimoto, Misaka Kimura, Shingo Oda

European Journal of Applied Physiology　116　(6)　1279-1280　2016/06/01
Publisher: Springer Verlag
DOI： 10.1007/s00421-016-3376-0 　

ISSN： 1439-6319
A novel approach for measuring energy expenditure of a single sit-to-stand movement Peer-reviewed

Yoichi Hatamoto, Yosuke Yamada, Yasuki Higaki, Hiroaki Tanaka

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY　116　(5)　997-1004　2016/05

DOI： 10.1007/s00421-016-3355-5 　

ISSN： 1439-6319

eISSN： 1439-6327
認知機能低下高齢者に対する3年間の長期運動介入が有酸素能力,認知機能および脳容積に及ぼす効果

古瀬裕次郎, 池永昌弘, 山田陽介, 森村和浩, 武田典子, 合馬慎二, 坪井義夫, 山田達夫, 松田博史, 清永明, 桧垣靖樹, 田中宏暁

若手研究者のための健康科学研究助成成果報告書　31　(31)　23‐29-29　2016/04/30
Publisher: 明治安田厚生事業団
Physical Activity and Fitness of Elderly People―Basic Study Physical Activity Level Target Setting According to Fitness and Health Levels―

吉中康子, 糸井亜弥, 山田陽介, 寄本明, 木村みさか

ウォーキング研究　(19)　21‐29　2016/03/10
地域在住自立高齢者の追跡2年間における転倒経験とその関連要因

桝本妙子, 山田陽介, 山縣恵美, 小松光代, 續田尚美, 岡山寧子, 木村みさか, 亀岡スタディグループ

同志社看護　1　9-17　2016/03
Publisher: 同志社女子大学看護学会
ISSN： 2424-0400

eISSN： 2424-0184
Lower muscle co-contraction in flutter kicking for competitive swimmers Peer-reviewed

Yuji Matsuda, Masami Hirano, Yosuke Yamada, Yasushi Ikuta, Teruo Nomura, Hiroaki Tanaka, Shingo Oda

HUMAN MOVEMENT SCIENCE　45　40-52　2016/02

DOI： 10.1016/j.humov.2015.11.001 　

ISSN： 0167-9457

eISSN： 1872-7646
筋力を決定する筋の量的/質的要因の解明 : 新たな筋力トレーニング法の創出に向けて

赤木亮太, 江間諒一, 宮本直和, 山田陽介

特別教育・研究報告集　261-264　2016
Publisher: 芝浦工業大学連携推進部
ISSN： 2185-7326
Relationship between the amount of physical activity and fitness in preschool children : Evaluation of the necessary number of steps, physical activity level, and du-ration of physical activity by intensity

青木好子, 金子眞理, 磯野眞紀子, 渡邊裕也, 山田陽介, 木村みさか

ウォーキング研究 = Walking research　(20)　79-87　2016
Publisher: 日本ウォーキング学会
サルコペニア研究の源流と判定の問題点,サルコペニアとフレイル評価の役割と課題 : Rapid Geriatric Assessment日本語版の紹介 (特集介護予防とサルコペニア)

山田陽介, 山田実

介護福祉・健康づくり　3　(1)　11-18　2016
Publisher: [日本介護福祉・健康づくり学会] ; 2014-
ISSN： 2188-2428
Job satisfaction and goal orientations as predictors of trait anxiety in Japanese female professional baseball

早乙女誉, 山田陽介, 森原徹

JAPANESE JOURNAL of ELITE SPORTS SUPPORT　7　(0)　1-10　2016
Publisher: 独立行政法人日本スポーツ振興センター国立スポーツ科学センター
DOI： 10.32155/jissjjess.7.0_1 　

ISSN： 2188-8183

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This study aimed to examine the relationship between job satisfaction, goal orientation and trait anxiety among Japanese female professional baseball players. Fifty seven players completed a questionnaire survey in February and March 2013. The research items included 1) job satisfaction, 2) trait anxiety, 3) goal orientation, back ground information (e.g., age, years of baseball experience and position). Multiple regression analyses were used to examine the relationship between job satisfaction and trait anxiety. Job satisfaction, achievement goal s, age and years of baseball experience were entered into the analyses as independent variables. In addition, trait anxiety and its five subscales entered into the each analysis as dependent variable. The results showed that job satisfaction wasn't a signi ficant predictor of trait anxiety. However, ego orientation and years of baseball experience related to trait anxiety. These results indicate that controlling player's ego orientation might decrease their trait anxiety, but increasing their job satisfactio n can't decrease it.
Physical performance and cognitive functions in community-dwelling older people at risk of Musculoskeletal Ambulation Disorder Symptom Complex (MADS) - The Nakagawa study - The N

Yujiro Kose, Masahiro Ikenaga, Yosuke Yamada, Kazuhiro Morimura, Noriko Takeda, Yukiko Machida, Midori Kuriyama, Misaka Kimura, Akira Kiyonaga, Yasuki Higaki, Hiroaki Tanaka

Japanese Journal of Physical Fitness and Sports Medicine　65　(6)　521-531　2016
Publisher: Japanese Society of Physical Fitness and Sports Medicine
DOI： 10.7600/jspfsm.65.521 　

ISSN： 0039-906X
Decline in objective physical activity over a 10-year period in a Japanese elementary school Peer-reviewed

Aya Itoi, Yosuke Yamada, Satoshi Nakae, Misaka Kimura

Journal of Physiological Anthropology　34　(1)　38　2015/11/06
Publisher: BioMed Central Ltd.
DOI： 10.1186/s40101-015-0078-y 　

ISSN： 1880-6805 1880-6791
CHARACTERISTICS OF BRAIN ATROPHY, PHYSICAL PERFORMANCE AND COGNITIVE FUNCTIONS IN COMMUNITY-DWELLING ELDERLY

Y. Kose, M. Ikenaga, K. Morimura, Y. Yamada, N. Takeda, A. Kiyonaga, H. Tanaka, Y. Higaki

GERONTOLOGIST　55　105-105　2015/11

ISSN： 0016-9013

eISSN： 1758-5341
Decline in objective physical activity over a 10-year period in a Japanese elementary school Peer-reviewed

Aya Itoi, Yosuke Yamada, Satoshi Nakae, Misaka Kimura

JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY　34　2015/11

DOI： 10.1186/s40101-015-0078-y 　

ISSN： 1880-6805
AGE-RELATED ULTRASOUND CHANGES IN MUSCLE QUANTITY AND QUALITY IN WOMEN Peer-reviewed

Yoshihiro Fukumoto, Tome Ikezoe, Yosuke Yamada, Rui Tsukagoshi, Masatoshi Nakamura, Yui Takagi, Misaka Kimura, Noriaki Ichihashi

ULTRASOUND IN MEDICINE AND BIOLOGY　41　(11)　3013-3017　2015/11

DOI： 10.1016/j.ultrasmedbio.2015.06.017 　

ISSN： 0301-5629

eISSN： 1879-291X
Association of sagittal spinal alignment with thickness and echo intensity of lumbar back muscles in middle-aged and elderly women Peer-reviewed

Mitsuhiro Masaki, Tome Ikezoe, Yoshihiro Fukumoto, Seigo Minami, Rui Tsukagoshi, Kaoru Sakuma, Satoko Ibuki, Yosuke Yamada, Misaka Kimura, Noriaki Ichihashi

Archives of Gerontology and Geriatrics　61　(2)　197-201　2015/09/01
Publisher: Elsevier Ireland Ltd
DOI： 10.1016/j.archger.2015.05.010 　

ISSN： 1872-6976 0167-4943
Association of sagittal spinal alignment with thickness and echo intensity of lumbar back muscles in middle-aged and elderly women Peer-reviewed

Mitsuhiro Masaki, Tome Ikezoe, Yoshihiro Fukumoto, Seigo Minami, Rui Tsukagoshi, Kaoru Sakuma, Satoko Ibuki, Yosuke Yamada, Misaka Kimura, Noriaki Ichihashi

ARCHIVES OF GERONTOLOGY AND GERIATRICS　61　(2)　197-201　2015/09

DOI： 10.1016/j.archger.2015.05.010 　

ISSN： 0167-4943

eISSN： 1872-6976
地域在住自立高齢者における転倒リスクの関連要因とその性差亀岡スタディ

桝本妙子, 山田陽介, 山田実, 中谷友樹, 三宅基子, 渡邊裕也, 吉田司, 横山慶一, 山縣恵美, 伊達平和, 南里妃名子, 小松光代, 吉中康子, 藤原佳典, 岡山寧子, 木村みさか

日本公衆衛生雑誌　62　(8)　390-401　2015/08
Publisher: 日本公衆衛生学会
ISSN： 0546-1766

eISSN： 2187-8986
高齢者の閉じこもり予防支援に関する国内外の研究動向

山縣恵美, 木村みさか, 山田陽介, 小松光代, 杉原百合子, 岡山寧子

日本看護研究学会雑誌　38　(3)　314-314　2015/07
Publisher: (一社)日本看護研究学会
ISSN： 0285-9262

eISSN： 2189-6100
超高齢社会におけるフレイルの意義を考える《フレイルへの介入》3)社会的フレイルへの介入―亀岡スタディからの報告

木村みさか, 山田陽介, 山縣恵美

モダンフィジシャン　35　(7)　895-900　2015/07/01

ISSN： 0913-7963
Association between the physical activity and heart rate corrected-QT interval in older adults Peer-reviewed

Ryoma Michishita, Chika Fukae, Rikako Mihara, Masahiro Ikenaga, Kazuhiro Morimura, Noriko Takeda, Yosuke Yamada, Yasuki Higaki, Hiroaki Tanaka, Akira Kiyonaga

GERIATRICS & GERONTOLOGY INTERNATIONAL　15　(7)　895-901　2015/07

DOI： 10.1111/ggi.12365 　

ISSN： 1444-1586

eISSN： 1447-0594
Effects of 2 weeks of low-intensity cycle training with different pedaling rates on the work rate at lactate threshold Peer-reviewed

Masami Hirano, Munehiro Shindo, Saki Mishima, Kazuhiro Morimura, Yoshiyasu Higuchi, Yosuke Yamada, Yasuki Higaki, Akira Kiyonaga

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY　115　(5)　1005-1013　2015/05

DOI： 10.1007/s00421-014-3081-9 　

ISSN： 1439-6319

eISSN： 1439-6327
Influence of Dietary Sodium and Potassium Intake on the Heart Rate Corrected-OT Interval in Elderly Subjects Peer-reviewed

Ryoma Michishita, Kazuko Ishikawa-Takata, Eiichi Yoshimura, Rikako Mihara, Masahiro Ikenaga, Kazuhiro Morimura, Noriko Takeda, Yosuke Yamada, Yasuki Higaki, Hiroaki Tanaka, Akira Kiyonaga

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY　61　(2)　138-146　2015/04

DOI： 10.3177/jnsv.61.138 　

ISSN： 0301-4800

eISSN： 1881-7742
大学男子サッカー選手の前脛骨筋持久力と筋血流応答

池永昌弘, 伊古田健夫, 平野雅巳, 森村和浩, 山田陽介, 進藤宗洋, 清永明

福岡大学スポーツ科学研究　45　(2)　35-42　2015/03/31
Publisher: Fukuoka University
ISSN： 1345-9244
WEBを用いた身体活動測定システムの3軸加速度計による妥当性

難波秀行, 黒坂裕香, 湊久美子, 山田陽介, 木村みさか

Research in Exercise Epidemiology　17　(1)　19-28　2015/03/31

ISSN： 1347-5827
Use of a web-based physical activity record system to analyze behavior in a large population: Cross-sectional study Peer-reviewed

Namba, H., Yamada, Y., Ishida, M., Takase, H., Kimura, M.

Journal of Medical Internet Research　17　(3)　e74　2015/03

DOI： 10.2196/jmir.3923 　

ISSN： 1439-4456
「超音波装置を用いた評価と臨床への応用」第1回超音波画像診断装置を用いた骨格筋の量的・質的評価

福元喜啓, 池添冬芽, 山田陽介, 市橋則明

理学療法学　42　(1)　65-71　2015/02/20
Publisher: Japanese Society of Physical Therapy
DOI： 10.15063/rigaku.KJ00009814230 　

ISSN： 0289-3770
Factors Associated With Non-participation in a Face-to-Face Second Survey Conducted 5 Years After the Baseline Survey Peer-reviewed

Megumi Hara, Chisato Shimanoe, Yasuko Otsuka, Yuichiro Nishida, Hinako Nanri, Mikako Horita, Jun Yasukata, Nobuyuki Miyoshi, Yosuke Yamada, Yasuki Higaki, Keitaro Tanaka

JOURNAL OF EPIDEMIOLOGY　25　(2)　117-125　2015/02

DOI： 10.2188/jea.JE20140116 　

ISSN： 0917-5040

eISSN： 1349-9092
高校野球選手における肩関節のHyper External Rotation Test陽性率とそのセルフチェック法の有用性

森原徹, 平本真知子, 木田圭重, 古川龍平, 祐成毅, 松井知之, 東善一, 瀬尾和弥, 北條達也, 山田陽介, 来田宣幸, 堀井基行, 久保俊一

日本臨床スポーツ医学会誌　23　(1)　20-24　2015/01/31
Publisher:
ISSN： 1346-4159
Clinical application of radial magnetic resonance imaging for evaluation of rotator cuff tear

Honda, H., Morihara, T., Arai, Y., Horii, M., Ito, H., Furukawa, R., Kida, Y., Sukenari, T., Ikoma, K., Oda, R., Yamada, Y., Fujiwara, H., Kubo, T.

Orthopaedics and Traumatology: Surgery and Research　101　(6)　2015

DOI： 10.1016/j.otsr.2015.06.007 　
Clinical application of radial magnetic resonance imaging for evaluation of rotator cuff tear,Application clinique de l'imagerie à une résonance magnétique radiale dans l'analyse de lésions de la coiffe des rotateurs

Honda, H., Morihara, T., Arai, Y., Horii, M., Ito, H., Furukawa, R., Kida, Y., Sukenari, T., Ikoma, K., Oda, Y., Yamada, Y., Fujiwara, H., Kubo, T.

Revue de Chirurgie Orthopedique et Traumatologique　101　(6)　473-473　2015

DOI： 10.1016/j.rcot.2015.06.015 　
Fall risk factors and sex differences among community-dwelling elderly individuals in Japan. A Kameoka study

Masumoto, T., Yamada, Y., Yamada, M., Nakaya, T., Miyake, M., Watanabe, Y., Yoshida, T., Yokoyama, K., Yamagata, E., Date, H., Nanri, H., Komatsu, M., Yoshinaka, Y., Fujiwara, Y., Okayama, Y., Kimura, M.

[Nihon kōshū eisei zasshi] Japanese journal of public health　62　(8)　2015

DOI： 10.11236/jph.62.8_390 　
New approach focused on muscle cell mass and muscle composition for the definition of skeletal muscle mass and sarcopenia

Yosuke Yamada

Japanese Journal of Physical Fitness and Sports Medicine　64　(4)　461-472　2015
Publisher: Japanese Society of Physical Fitness and Sports Medicine
DOI： 10.7600/jspfsm.64.461 　

ISSN： 0039-906X
高齢女性における超音波画像から算出した筋輝度と運動機能との関連性

渡邊裕也, 山田陽介, 吉中康子, 木村みさか

京都学園大学経営学部論集　24　(1)　95-105　2014/12/30
Publisher: 京都学園大学経営学部学会
ISSN： 0916-734X
Intracyclic Velocity Variation and Arm Coordination for Different Skilled Swimmers in the Front Crawl Peer-reviewed

Yuji Matsuda, Yosuke Yamada, Yasushi Ikuta, Teruo Nomura, Shingo Oda

JOURNAL OF HUMAN KINETICS　44　(1)　67-74　2014/12

DOI： 10.2478/hukin-2014-0111 　

ISSN： 1640-5544

eISSN： 1899-7562
地域に在住する自立高齢者における閉じこもりリスクの実態と体力との関連

山縣恵美, 木村みさか, 三宅基子, 山田陽介, 桝本妙子, 渡邊裕也, 吉田司, 横山慶一, 吉中康子, 杉原百合子, 小松光代, 岡山寧子, 井上恒男

日本公衆衛生雑誌　61　(11)　671-678　2014/11/15
Publisher:
DOI： 10.11236/jph.61.11_671 　

ISSN： 0546-1766
Measurement of body composition in response to a short period of overfeeding Peer-reviewed

Hiroyuki Sagayama, Yu Jikumaru, Akiko Hirata, Yosuke Yamada, Eiichi Yoshimura, Mamiko Ichikawa, Yoichi Hatamoto, Naoyuki Ebine, Akira Kiyonaga, Hiroaki Tanaka, Yasuki Higaki

JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY　33　29　2014/09

DOI： 10.1186/1880-6805-33-29 　

ISSN： 1880-6791

eISSN： 1880-6805
女子プロ野球選手の関節可動域特性

平本真知子, 森原徹, 松井知之, 東善一, 瀬尾和弥, 江藤寿明, 吉田司, 祐成毅, 山田陽介, 来田宣幸, 堀井基行, 久保俊一

日本臨床スポーツ医学会誌　22　(3)　545-551　2014/08/31
Publisher:
ISSN： 1346-4159
京都における青少年に対するスポーツ検診の現状と課題

森原徹, 木田圭重, 琴浦義浩, 吉岡直樹, 仲川春彦, 祐成毅, 岩田圭生, 松井知之, 瀬尾和弥, 平本真知子, 東善一, 西尾大地, 山田陽介, 北條達也, 来田宣幸, 生駒和也, 立入克敏, 原邦夫, 堀井基行, 久保俊一

日本臨床スポーツ医学会誌　22　(3)　395-401　2014/08/31
Publisher:
ISSN： 1346-4159
非アスリートの食事内容自己選択型グリコーゲンローディングにおける糖質摂取量と筋グリコーゲンの変化

塩瀬圭佑, 山田陽介, 上野誠也

ランニング学研究 = Journal of running science　25　(2)　17-23　2014/08
Publisher: ランニング学会
ISSN： 0919-4312
The Establishment of Effective Intervention to Prevent Sarcopenia for Elderly

渡邊裕也, 山田陽介, 三宅基子, 横山慶一, 吉田司

デサントスポーツ科学　35　78-86　2014/06/06
Publisher: 石本記念デサントスポーツ科学振興財団事務局
ISSN： 0285-5739
投球動作における投球側股関節周囲筋の経時的な筋活動パターンについて

東善一, 森原徹, 松井知之, 瀬尾和弥, 平本真知子, 来田宣幸, 山田陽介, 中村康雄, 北條達也, 堀井基行, 久保俊一

同志社スポーツ健康科学　(6)　24-28　2014/06/03
Publisher: 同志社大学スポーツ健康科学会
DOI： 10.14988/pa.2017.0000013554 　

ISSN： 1883-4132

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The evaluation of lower extremity function is important for throwing disorders. The purpose of this study was to investigate the muscle activation patterns around hip during pitching motion by three-dimensional motion analysis system synchronized with surface electromyography. The timing of peak tensor fasciae latae and gluteus medius activities was before maximum knee elevation of non-dominant lower extremity in wind-up phase. The timing of peak adductor longus(AL) and rectus femoris(RF) activities was immediately after non-dominant foot contact. This study suggested that AL could put a brake on moving body to the catcher excessively and help the pelvis rotating in the direction of throwing.
Dynapenia, gait speed and daily physical activity measured using triaxial accelerometer in older Japanese men Peer-reviewed

Ikenaga Masahiro, Yamada Yosuke, Takeda Noriko, Kimura Misaka, Higaki Yasuki, Tanaka Hiroaki, Kiyonaga Akira, Nakagawa Study Group

JPFSM　3　(1)　147-154　2014/05
Publisher: The Japanese Society of Physical Fitness and Sports Medicine
DOI： 10.7600/jpfsm.3.147 　

ISSN： 2186-8131

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This cross-sectional study was performed to determine the relationship between the intensity of daily physical activity (PA) assessed by triaxial accelerometer (ACCtri) and muscle strength or gait speed. We measured the hand grip strength (HGS) and knee extension strength (KES) as well as preferred gait speed (PGS) and maximal gait speed (MGS) of a total of 178 community-dwelling elderly men aged 70-79 years. The duration and intensity of PA were evaluated by ACCtri on eight consecutive days, and the total duration of each level of activity intensity (Inactivity, Light PA: LPA, Moderate PA: MPA, and Vigorous PA: VPA) and daily step count were also measured. After adjustment for age, body mass index (BMI) and body fat percentage, KES and MGS were significantly correlated with step count. The duration of MPA was correlated with KES (r = 0.208, P < 0.01) and MGS (r = 0.213, P < 0.05). PGS and HGS were not significantly correlated with any PA parameters. MPA and step counts were significantly, but weakly, related to KES and MGS. The results suggest that a longer time spent on either daily ambulatory activity or MPA may be associated with age-associated loss of muscle strength (dynapenia) and gait decline in older men.
京都府高等学校硬式野球選手に対する肩・肘障害予防の取り組み~コンディショニング指導を含めたメディカルチェック~

森原徹, 木田圭重, 岩田圭生, 古川龍平, 祐成毅, 松井知之, 東善一, 瀬尾和弥, 平本真知子, 伊藤盛春, 相馬寛人, 北條達也, 山田陽介, 堀井基行, 久保俊一

日本臨床スポーツ医学会誌　22　(2)　309-317　2014/04/30
Publisher:
ISSN： 1346-4159
サルコペニア―成因と対策概念・診断基準骨格筋量・筋力の評価法

山田陽介

医学のあゆみ　248　(9)　670-678　2014/03/01
Publisher:
ISSN： 0039-2359
身体組成の測定原理と応用身体組成研究の新たな展開―組織・器官・細胞レベルのアプローチ,脂肪から骨格筋へ―

山田陽介

体育の科学　64　(3)　149-155　2014/03/01
Publisher:
ISSN： 0039-8985
Application of segmental bioelectrical impedance spectroscopy to the assessment of skeletal muscle cell mass in elderly men Peer-reviewed

Yosuke Yamada, Kaori Matsuda, Mikko P. Bjorkman, Misaka Kimura

GERIATRICS & GERONTOLOGY INTERNATIONAL　14　129-134　2014/02

DOI： 10.1111/ggi.12212 　

ISSN： 1444-1586

eISSN： 1447-0594
Relationship between homebound status and physical fitness in the community-dwelling elderly population

Yamagata, E., Kimura, M., Miyake, M., Yamada, Y., Masumoto, T., Watanabe, Y., Yoshida, T., Yokoyama, K., Yoshinaka, Y., Sugihara, Y., Komatsu, M., Okayama, Y., Inoue, T.

[Nihon kōshū eisei zasshi] Japanese journal of public health　61　(11)　2014
日記と活動量計の配布による自己管理型生活習慣改善介入プログラムが老年期うつ状態に与える影響 Peer-reviewed

山田陽介, 山縣恵美, 横山慶一, 吉田司, 木村みさか

ジェロントロジー研究報告　11　32-36　2014
Sports and physical Activity of elementary school students using ICT analysis system

難波秀行, 山田陽介, 木村みさか

SSFスポーツ政策研究 = SSF journal of sport for everyone　3　(1)　212-219　2014
Publisher: 笹川スポーツ財団
ISSN： 2186-9707
Trial of a new lower limbs and trunk functional evaluation for pitcher -physical characteristic of the baseball player with throwing disorder

Tomoyuki Matsui, Toru Morihara, Machiko Hiramoto, Yoshikazu Azuma, Kazuya Seo, Tetsuya Miyazaki, Noriyuki Kida, Yosuke Yamada, Yoshikazu Kida, Takumi Ikeda, Motoyuki Horii, Toshikazu Kubo

Japanese Journal of Physical Fitness and Sports Medicine　63　(5)　463-468　2014
Publisher: Japanese Society of Physical Fitness and Sports Medicine
DOI： 10.7600/jspfsm.63.463 　

ISSN： 0039-906X
Estimation of thigh muscle cross-sectional area by single- and multifrequency segmental bioelectrical impedance analysis in the elderly Peer-reviewed

Yosuke Yamada, Masahiro Ikenaga, Noriko Takeda, Kazuhiro Morimura, Nobuyuki Miyoshi, Akira Kiyonaga, Misaka Kimura, Yasuki Higaki, Hiroaki Tanaka

JOURNAL OF APPLIED PHYSIOLOGY　116　(2)　176-182　2014/01

DOI： 10.1152/japplphysiol.00772.2013 　

ISSN： 8750-7587

eISSN： 1522-1601
Effects of rapid weight loss and regain on body composition and energy expenditure Peer-reviewed

Hiroyuki Sagayama, Eiichi Yoshimura, Yosuke Yamada, Mamiko Ichikawa, Naoyuki Ebine, Yasuki Higaki, Akira Kiyonaga, Hiroaki Tanaka

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM　39　(1)　21-27　2014/01

DOI： 10.1139/apnm-2013-0096 　

ISSN： 1715-5312

eISSN： 1715-5320
The Relationship between Running Velocity and the Energy Cost of Turning during Running Peer-reviewed

Yoichi Hatamoto, Yosuke Yamada, Hiroyuki Sagayama, Yasuki Higaki, Akira Kiyonaga, Hiroaki Tanaka

PLOS ONE　9　(1)　e81850　2014/01

DOI： 10.1371/journal.pone.0081850 　

ISSN： 1932-6203
The physical activity level in children can be increased by walking to school (Comparison in 6th graders spending different time in walking to school)

木村みさか, 木村みさか, 糸井亜弥, 山田陽介, 山田陽介, 山田陽介

ウォーキング研究　(17)　95-103　2013/12/31
Publisher: 日本ウォーキング学会
Validity of doubly labeled water in obese subjects: questioning the validity of any technique requires an indisputable accuracy of the reference method Peer-reviewed

Yosuke Yamada, Stephane Blanc, Yuichiro Nishida, Kazutoshi Nishijima, Naoyuki Ebine, Timothy Shriver, Dale A. Schoeller

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM　305　(9)　E1178-E1180　2013/11

DOI： 10.1152/ajpendo.00355.2013 　

ISSN： 0193-1849

eISSN： 1522-1555
Injuries in a Japanese Division I Collegiate American Football Team: A 3-Season Prospective Study Peer-reviewed

Junta Iguchi, Yosuke Yamada, Misaka Kimura, Yoshihiko Fujisawa, Tatsuya Hojo, Kenji Kuzuhara, Noriaki Ichihashi

JOURNAL OF ATHLETIC TRAINING　48　(6)　818-825　2013/11

DOI： 10.4085/1062-6050-48.4.15 　

ISSN： 1062-6050

eISSN： 1938-162X
Long-term calorie restriction decreases metabolic cost of movement and prevents decrease of physical activity during aging in rhesus monkeys Peer-reviewed

Yosuke Yamada, Ricki J. Colman, Joseph W. Kemnitz, Scott T. Baum, Rozalyn M. Anderson, Richard Weindruch, Dale A. Schoeller

EXPERIMENTAL GERONTOLOGY　48　(11)　1226-1235　2013/11

DOI： 10.1016/j.exger.2013.08.002 　

ISSN： 0531-5565

eISSN： 1873-6815
Association between lifestyle and physical activity level in the elderly: a study using doubly labeled water and simplified physical activity record Peer-reviewed

Yosuke Yamada, Risa Noriyasu, Keiichi Yokoyama, Tomoaki Osaki, Tetsuji Adachi, Aya Itoi, Taketoshi Morimoto, Shingo Oda, Misaka Kimura

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY　113　(10)　2461-2471　2013/10

DOI： 10.1007/s00421-013-2682-z 　

ISSN： 1439-6319
高齢者向けの運動教室が参加者の身体機能と医療費に及ぼす効果

渡邊裕也, 山田陽介, 三宅基子, 木村みさか, 石井直方

厚生の指標　60　(11)　26-32　2013/09/15
Publisher: 厚生労働統計協会
ISSN： 0452-6104
Comparison of single-or multifrequency bioelectrical impedance analysis and spectroscopy for assessment of appendicular skeletal muscle in the elderly Peer-reviewed

Yosuke Yamada, Yuya Watanabe, Masahiro Ikenaga, Keiichi Yokoyama, Tsukasa Yoshida, Taketoshi Morimoto, Misaka Kimura

Journal of Applied Physiology　115　(6)　812-818　2013/09/15
Publisher: 6
DOI： 10.1152/japplphysiol.00010.2013 　

ISSN： 8750-7587 1522-1601
高校生野球投手における投球側下肢に着目した投球動作解析

瀬尾和弥, 森原徹, 松井知之, 東善一, 平本真知子, 木田圭重, 山田陽介, 中村康雄, 北條達也, 堀井基行, 久保俊一

日本臨床スポーツ医学会誌　21　(3)　618-622　2013/08/31
Publisher: 日本臨床スポーツ医学会
ISSN： 1346-4159
Longitudinal change in energy expenditure and effects on energy requirements of the elderly Peer-reviewed

Jamie A. Cooper, Todd M. Manini, Chad M. Paton, Yosuke Yamada, James E. Everhart, Steve Cummings, Dawn C. Mackey, Anne B. Newman, Nancy W. Glynn, Fran Tylavsky, Tamara Harris, Dale A. Schoeller

NUTRITION JOURNAL　12　73　2013/06

DOI： 10.1186/1475-2891-12-73 　

ISSN： 1475-2891
Physical fitness and depression symptoms in community-dwelling elderly women

YAMAGATA Emi, YAMADA Yosuke, SUGIHARA Yuriko, KOMATSU Mitsuyo, KIMURA Misaka, OKAYAMA Yasuko

Jpn J Public Health　60　(4)　231-240　2013/04/15
Publisher: Japanese Society of Public Health
DOI： 10.11236/jph.60.4_231 　

ISSN： 0546-1766

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Objectives The aim of this study was to examine the relationship between geriatric depression scale (GDS) score and elements of physical fitness in community-dwelling, healthy, elderly women in Japan. Methods This cross-sectional study involved a total of 886 healthy elderly women (aged ≥65 years) living in Kyoto prefecture. Women voluntarily participated in physical performance tests. One-leg standing time, leg power, knee extension strength, grip strength, endurance capacity, trunk flexion, usual and maximal gait speed, chair stand, chair stepping, and functional reach were examined as fitness tests. A 15-item GDS and a battery of health status questionnaires were used to assess mental and physical health status. Results Of the participants, 21.1% had a GDS score of ≥5 and were categorized as the depression group (D group). Leg power, knee extension strength, endurance capacity, gait speed, and chair stepping ability were significantly lower in the D group than in the non-depression group (GDS score <5; ND group). After adjustment for physical characteristics, eating habits, and physical activity levels as co-variances, leg power, knee extension strength, and endurance capacity remained significantly lower in the D group than in the ND group (P<0.05). Conclusion A considerable number of active, healthy, elderly women who voluntarily participated in this study reported depressive symptoms. Reduced leg power, knee extension strength, and endurance capacity were associated with depressive symptoms independently of physical activity levels. These results suggest that exercise intervention to increase leg strength and endurance capacity may improve depressive symptoms in elderly women.
高齢者の身体活動量向上による骨格筋細胞量向上とうつ傾向改善との関連

山田陽介, 山縣恵美, 木村みさか

健康医科学研究助成論文集　(28)　26-35　2013/03/15
Physical activity level, daitary habits and muscle volume of the people with intellectual disabilities

Aoki Yoshiko, Tokuhiro Yuka, Yamada Yosuke, Kaneko Mari, Kimura Misaka

保育研究　(41)　1-9　2013/03
Publisher: 平安女学院大学
ISSN： 0386-6246

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知的障害児者の肥満対策の基礎資料を得ることを目的として、知的障害のある小学校特別支援学級在籍児童6名と成人4名を対象に、身体活動量、食生活を調査し、成人4名に対しては成人の骨格筋量(細胞内量)を測定した。栄養摂取量では、摂取エネルギー量は同年代値に近い値が多く、児童で炭水化物、成人で脂質が多い傾向があった。身体活動量は、同年代値と比較すると、児童では高く、成人では女性は低く、男性は高い値であった。平日休日の活動量は、児童では休日に減少する傾向があり、成人では半数は休日に多かった。成人の体重あたりの筋細胞量は、肥満度II・IIIである女性各1名は、同世代値より少なく、肥満度Iの男性では平均的であった。これらのことから、児童と成人では食生活、活動量に異なる特徴が認められ、成人においては身体活動量と筋細胞量の関連が示唆された。
サルコペニアに対する高強度運動の有効性

江藤幹, 山田陽介, 山田陽介, 山田陽介

健康支援　15　(1)　7-12　2013/02/01
Publisher: 日本健康支援学会
ISSN： 1345-0174
Association between physical performance and electrocardiographic heart rate corrected-QT interval in elderly subjects

Ryoma Michishita, Chika Fukae, Rikako Mihara, Masahiro Ikenaga, Kazuhiro Morimura, Noriko Takeda, Yosuke Yamada, Yasuki Higaki, Hiroaki Tanaka, Akira Kiyonaga

Japanese Journal of Physical Fitness and Sports Medicine　62　(4)　283-291　2013
Publisher: 一般社団法人日本体力医学会
DOI： 10.7600/jspfsm.62.283 　

ISSN： 0039-906X
Relationships between duration of various physical activities and physical activity level in children

Yoshitake Oshima, Satoshi Nakae, Yosuke Yamada, Misaka Kimura, Haruo Ozawa, Kazuhiro Suzuki, Kazuhumi Hirakawa, Kojiro Ishii

Japanese Journal of Physical Fitness and Sports Medicine　62　(5)　391-397　2013
Publisher: 一般社団法人日本体力医学会
DOI： 10.7600/jspfsm.62.391 　

ISSN： 0039-906X
Relations between daily energy expenditure and body fatness, physical fitness in primary school children using doubly labeled water method and accelerometer

Satoshi Nakae, Yosuke Yamada, Misaka Kimura, Kazuhiro Suzuki, Haruo Ozawa, Kazufumi Hirakawa, Kojiro Ishii

Japanese Journal of Physical Fitness and Sports Medicine　62　(5)　353-360　2013
Publisher: 一般社団法人日本体力医学会
DOI： 10.7600/jspfsm.62.353 　

ISSN： 0039-906X
Whole-body and segmental muscle volume are associated with ball velocity in high school baseball pitchers. International-journal Peer-reviewed

Yamada Y, Yamashita D, Yamamoto S, Matsui T, Seo K, Azuma Y, Kida Y, Morihara T, Kimura M

Open access journal of sports medicine　4　89-95　2013

DOI： 10.2147/OAJSM.S42352 　

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The aim of the study was to examine the relationship between pitching ball velocity and segmental (trunk, upper arm, forearm, upper leg, and lower leg) and whole-body muscle volume (MV) in high school baseball pitchers. Forty-seven male high school pitchers (40 right-handers and seven left-handers; age, 16.2 ± 0.7 years; stature, 173.6 ± 4.9 cm; mass, 65.0 ± 6.8 kg, years of baseball experience, 7.5 ± 1.8 years; maximum pitching ball velocity, 119.0 ± 9.0 km/hour) participated in the study. Segmental and whole-body MV were measured using segmental bioelectrical impedance analysis. Maximum ball velocity was measured with a sports radar gun. The MV of the dominant arm was significantly larger than the MV of the non-dominant arm (P < 0.001). There was no difference in MV between the dominant and non-dominant legs. Whole-body MV was significantly correlated with ball velocity (r = 0.412, P < 0.01). Trunk MV was not correlated with ball velocity, but the MV for both lower legs, and the dominant upper leg, upper arm, and forearm were significantly correlated with ball velocity (P < 0.05). The results were not affected by age or years of baseball experience. Whole-body and segmental MV are associated with ball velocity in high school baseball pitchers. However, the contribution of the muscle mass on pitching ball velocity is limited, thus other fundamental factors (ie, pitching skill) are also important.
Inter-sport variability of muscle volume distribution identified by segmental bioelectrical impedance analysis in four ball sports. Peer-reviewed

Yamada Y, Masuo Y, Nakamura E, Oda S

Open access journal of sports medicine　4　97-108　2013

DOI： 10.2147/OAJSM.S43512 　
A novel method for calculating the energy cost of turning during running. International-journal Peer-reviewed

Hatamoto Y, Yamada Y, Fujii T, Higaki Y, Kiyonaga A, Tanaka H

Open access journal of sports medicine　4　117-122　2013

DOI： 10.2147/OAJSM.S39206 　

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Although changes of direction are one of the essential locomotor patterns in ball sports, the physiological demand of turning during running has not been previously investigated. We proposed a novel approach by which to evaluate the physiological demand of turning. The purposes of this study were to establish a method of measuring the energy expenditure (EE) of a 180° turn during running and to investigate the effect of two different running speeds on the EE of a 180° turn. Eleven young, male participants performed measurement sessions at two different running speeds (4.3 and 5.4 km/hour). Each measurement session consisted of five trials, and each trial had a different frequency of turns. At both running speeds, as the turn frequency increased the gross oxygen consumption (V·O2) also increased linearly (4.3 km/hour, r = 0.973; 5.4 km/hour, r = 0.996). The V·O2 of a turn at 5.4 km/hour (0.55 [SD 0.09] mL/kg) was higher than at 4.3 km/hour (0.34 [SD 0.13] mL/kg) (P < 0.001). We conclude that the gross V·O2 of running at a fixed speed with turns is proportional to turn frequency and that the EE of a turn is different at different running speeds. The Different Frequency Accumulation Method is a useful tool for assessing the physiological demands of complex locomotor activity.
Echo intensity obtained from ultrasonography images reflecting muscle strength in elderly men Peer-reviewed

Yuya Watanabe, Yosuke Yamada, Yoshihiro Fukumoto, Tatsuro Ishihara, Keiichi Yokoyama, Tsukasa Yoshida, Motoko Miyake, Emi Yamagata, Misaka Kimura

CLINICAL INTERVENTIONS IN AGING　8　993-998　2013

DOI： 10.2147/CIA.S47263 　

ISSN： 1176-9092
高齢者における運動が医療費・介護保険料の軽減に役立つことを証明したい(サルコペニア対策を通じて)

木村みさか, 山田陽介

ウォーキング研究　(16)　19-30　2012/12/31
Publisher: 日本ウォーキング学会
女子学生におけるボディイメージと身体活動量,栄養素摂取量との関連

糸井亜弥, 山田陽介, 山田陽介, 木村みさか

ウォーキング研究　(16)　109-118　2012/12/31
Publisher: 日本ウォーキング学会
走行中における180°方向転換時の生理的負荷についての検討方向転換時におけるエネルギー消費量と走行速度の関係

畑本陽一, 山田陽介, 市川麻美子, 下山寛之, 桧垣靖樹, 清永明, 田中宏暁

体力科学　61　(6)　627-627　2012/12
Publisher: (一社)日本体力医学会
ISSN： 0039-906X

eISSN： 1881-4751
Physical activity, energy intake, and obesity prevalence among urban and rural schoolchildren aged 11-12 years in Japan Peer-reviewed

Aya Itoi, Yosuke Yamada, Yoshiyuki Watanabe, Misaka Kimura

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM　37　(6)　1189-1199　2012/12

DOI： 10.1139/H2012-100 　

ISSN： 1715-5312

eISSN： 1715-5320
Frailty, Sarcopenia, and Long-term Care Prevention

山田陽介, 山縣恵美, 木村みさか

京都府立医科大学雑誌　121　(10)　535-547　2012/10/25
Publisher: 京都府立医科大学
ISSN： 0023-6012
Validation of Web-Based Physical Activity Measurement Systems Using Doubly Labeled Water Peer-reviewed

Hideyuki Namba, Yukio Yamaguchi, Yosuke Yamada, Satoru Tokushima, Yoichi Hatamoto, Hiroyuki Sagayama, Misaka Kimura, Yasuki Higaki, Hiroaki Tanaka

JOURNAL OF MEDICAL INTERNET RESEARCH　14　(5)　2012/09

DOI： 10.2196/jmir.2253 　

ISSN： 1438-8871
Effectiveness of high-intensity exercise on metabolic syndrome

江藤幹, 山田陽介

健康支援　14　(2)　7-14　2012/09/01
Publisher: 日本健康支援学会
ISSN： 1345-0174
Relationship between decreased swimming velocity and muscle activity during 200-m front crawl Peer-reviewed

Yasushi Ikuta, Yuji Matsuda, Yosuke Yamada, Noriyuki Kida, Shingo Oda, Toshio Moritani

European Journal of Applied Physiology　112　(9)　3417-3429　2012/09
Publisher: 9
DOI： 10.1007/s00421-012-2321-0 　

ISSN： 1439-6319
The relationship between mood state and autonomic nervous system activity in female long-distance runners

FUJIBAYASHI MAMI, YAMADA YOSUKE, ANDO SOICHI, NAKAI SEIICHI, KIMURA MISAKA, MORITANI TOSHIO

スポーツ精神医学　9　54-58　2012/08/22
Publisher: 日本スポーツ精神医学会事務局
ISSN： 1349-4929
Validity of tri-axial accelerometer for estimating activity energy expenditure and the effect of physical activity on autonomic nervous system function in children

山田陽介, 藤林真美, 中江悟司

京都滋賀体育学研究 = Kyoto and Shiga journal of physical education, health and sport sciences　28　1-9　2012/07
Publisher: 京都滋賀体育学会
ISSN： 2187-7866
二重標識水法を用いたイヌのエネルギー要求量の測定

大辻一也, 後藤亜紗美, 櫻井富士朗, 伴武, 大川雅之, 梅田智重, 山田陽介

ペット栄養学会誌　15　(1)　12-16　2012/04/10
Publisher:
DOI： 10.11266/jpan.15.12 　

ISSN： 1344-3763 2185-7601
Effects of fear of falling on muscular coactivation during walking Peer-reviewed

Koutatsu Nagai, Minoru Yamada, Kazuki Uemura, Buichi Tanaka, Shuhei Mori, Yosuke Yamada, Tomoki Aoyama, Noriaki Ichihashi, Tadao Tsuboyama

AGING CLINICAL AND EXPERIMENTAL RESEARCH　24　(2)　157-161　2012/04

DOI： 10.3275/7716 　

ISSN： 1594-0667

eISSN： 1720-8319
Skeletal muscle quality assessed from echo intensity is associated with muscle strength of middle-aged and elderly persons Peer-reviewed

Yoshihiro Fukumoto, Tome Ikezoe, Yosuke Yamada, Rui Tsukagoshi, Masatoshi Nakamura, Natsuko Mori, Misaka Kimura, Noriaki Ichihashi

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY　112　(4)　1519-1525　2012/04

DOI： 10.1007/s00421-011-2099-5 　

ISSN： 1439-6319
Constructing an index of physical fitness age for Japanese elderly based on 7-year longitudinal data: sex differences in estimated physical fitness age Peer-reviewed

Misaka Kimura, Chinatsu Mizuta, Yosuke Yamada, Yasuko Okayama, Eitaro Nakamura

AGE　34　(1)　203-214　2012/02

DOI： 10.1007/s11357-011-9225-5 　

ISSN： 0161-9152
日本人高齢者における身体活動量評価方法の妥当性研究

髙田和子, 木村みさか, 山田陽介

研究結果報告書集 : 交通安全等・高齢者福祉　18　117-120　2012
Publisher: 三井住友海上福祉財団
Effects of slightly-weighted shoe intervention on lower limb muscle mass and gait patterns in the elderly

Masahiro Ikenaga, Yosuke Yamada, Rikako Mihara, Tomoe Yoshida, Keisuke Fujii, Kazuhiro Morimura, Masami Hirano, Koichiro Enishi, Munehiro Shindo, Akira Kiyonaga

Japanese Journal of Physical Fitness and Sports Medicine　61　(5)　469-477　2012
Publisher: 一般社団法人日本体力医学会
DOI： 10.7600/jspfsm.61.469 　

ISSN： 0039-906X
Effects of slightly-weighted shoe intervention on lower limb muscle mass and gait patterns in the elderly

Masahiro Ikenaga, Yosuke Yamada, Rikako Mihara, Tomoe Yoshida, Keisuke Fujii, Kazuhiro Morimura, Masami Hirano, Koichiro Enishi, Munehiro Shindo, Akira Kiyonaga

Japanese Journal of Physical Fitness and Sports Medicine　61　(5)　469-477　2012
Publisher: 日本体力医学会
DOI： 10.7600/jspfsm.61.469 　

ISSN： 0039-906X
身体活動量とHbA1c高値リスクに関する研究

安方惇, 徳田拓巳, 三好伸幸, 山田陽介, 田口尚人, 原めぐみ, 中村和代, 南里妃名子, 今泉猛, 坂本龍彦, 新地浩一, 田中恵太郎, 清永明, 田中宏暁, 桧垣靖樹

体力科学　60　(6)　813-813　2011/12
Publisher: (一社)日本体力医学会
ISSN： 0039-906X

eISSN： 1881-4751
PHYSICAL AND PERFORMANCE CHARACTERISTICS OF JAPANESE DIVISION 1 COLLEGIATE FOOTBALL PLAYERS Peer-reviewed

Junta Iguchi, Yosuke Yamada, Soichi Ando, Yoshihiko Fujisawa, Tatsuya Hojo, Kouji Nishimura, Kenji Kuzuhara, Yasuhiro Yuasa, Noriaki Ichihashi

JOURNAL OF STRENGTH AND CONDITIONING RESEARCH　25　(12)　3368-3377　2011/12

DOI： 10.1519/JSC.0b013e318215fc19 　

ISSN： 1064-8011
Differences in muscle coactivation during postural control between healthy older and young adults Peer-reviewed

Koutatsu Nagai, Minoru Yamada, Kazuki Uemura, Yosuke Yamada, Noriaki Ichihashi, Tadao Tsuboyama

ARCHIVES OF GERONTOLOGY AND GERIATRICS　53　(3)　338-343　2011/11

DOI： 10.1016/j.archger.2011.01.003 　

ISSN： 0167-4943
Does cerebral oxygenation affect cognitive function during exercise? Peer-reviewed

Soichi Ando, Masahiro Kokubu, Yosuke Yamada, Misaka Kimura

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY　111　(9)　1973-1982　2011/09

DOI： 10.1007/s00421-011-1827-1 　

ISSN： 1439-6319
Expression of proteasome subunit β5t in thymic epithelial tumors. Peer-reviewed

Yamada Y, Tomaru U, Ishizu A, Kiuchi T, Marukawa K, Matsuno Y, Kasahara M

The American journal of surgical pathology　35　1296-1304　2011/09
Publisher: 9
DOI： 10.1097/PAS.0b013e3182237f5d 　

ISSN： 0147-5185
Effects of toe and ankle training in older people: A cross-over study Peer-reviewed

Koutatsu Nagai, Takuya Inoue, Yosuke Yamada, Hiroshige Tateuchi, Tome Ikezoe, Noriaki Ichihashi, Tadao Tsuboyama

GERIATRICS & GERONTOLOGY INTERNATIONAL　11　(3)　246-255　2011/07

DOI： 10.1111/j.1447-0594.2010.00673.x 　

ISSN： 1444-1586

eISSN： 1447-0594
RECOVERY OF TIME ON LIMITS OF STABILITY FROM FUNCTIONAL FATIGUE IN DIVISION II COLLEGIATE ATHLETES Peer-reviewed

Toshimitsu Ishizuka, Rebecca A. Hess, Ben Reuter, Marc S. Federico, Yosuke Yamada

JOURNAL OF STRENGTH AND CONDITIONING RESEARCH　25　(7)　1905-1910　2011/07

DOI： 10.1519/JSC.0b013e3181e7ff86 　

ISSN： 1064-8011
Relationship between muscle mass and the intensity, volume, and type of daily physical activity in the elderly: basic study for developing exercise and physical activity reference for prevention sarcopenia

山田陽介, 飛奈卓郎, 木村みさか

Descente sports science　32　72-80　2011/06/02
Publisher: 石本記念デサントスポ-ツ科学振興財団事務局
ISSN： 0285-5739
Aerobic Exercise could Attenuates the Loss of Skeletal Muscle Mass of the Hip and Thigh during 12-wk Calorie Restriction

K. Watabe, E. Yoshimura, A. Hirata, H. Kumahara, M. Ayabe, T. Tobina, Y. Yamada, Y. Higaki, A. Kiyonaga, H. Tanaka

INTERNATIONAL JOURNAL OF OBESITY　35　S19-S19　2011/05

ISSN： 0307-0565
The role of exercise and physical activity in successful aging

山田陽介, 田中宏暁

Anti-aging science　2　(3)　316-323　2010/10/25
Publisher: メディカルレビュー社
ISSN： 1884-3891
生活習慣病とAnti-aging Science 第４回運動の視点から

山田陽介, 田中宏暁

Anti-aging Science　2　(3)　68-75　2010/10

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脳心血管抗加齢研究会機関誌メディカルビュー社
CLASSIFICATION OF STROKE TYPES IN RELATION TO STROKE RATE AND STROKE LENGTH IN 100M FRONT-CRAWL RACE

Yuji Matsuda, Yosuke Yamada, Toshifumi Akai, Yasushi Ikuta, Teruo Nomura, Shingo Oda

JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE　59　(5)　465-474　2010/10

ISSN： 0039-906X
CLASSIFICATION OF STROKE TYPES IN RELATION TO STROKE RATE AND STROKE LENGTH IN 100M FRONT-CRAWL RACE

Yuji Matsuda, Yosuke Yamada, Toshifumi Akai, Yasushi Ikuta, Teruo Nomura, Shingo Oda

JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE　59　(5)　465-474　2010/10

DOI： 10.7600/jspfsm.59.465 　

ISSN： 0039-906X
RELATIONSHIP BETWEEN CHANGES OF SWIMMING VELOCITY, STROKE RATE, STROKE LENGTH AND MUSCLE ACTIVITIES IN FRONT CRAWL SWIMMING

Yasushi Ikuta, Yuji Matsuda, Yosuke Yamada, Noriyuki Kida, Shingo Oda

JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE　59　(4)　427-438　2010/08

DOI： 10.7600/jspfsm.59.427 　

ISSN： 0039-906X

eISSN： 1881-4751
COMPARISON OF THE GAIT OF WOMEN WITH A LOAD ON THEIR BELLY AND THAT OF PREGNANT WOMEN

Hiroki Aoyama, Yosuke Yamada, Masahiro Shinya, Hideaki Kusumoto, Shingo Oda

JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE　59　(4)　375-388　2010/08

DOI： 10.7600/jspfsm.59.375 　

ISSN： 0039-906X
Does strenuous exercise attenuate cognitive performance?

安藤創一, 山田陽介, 木村みさか

Descente sports science　31　125-132　2010/06/03
Publisher: 石本記念デサントスポ-ツ科学振興財団事務局
ISSN： 0285-5739
SKILLED BASKETBALL PLAYERS ROTATE THEIR SHOULDERS MORE DURING RUNNING WHILE DRIBBLING Peer-reviewed

Keisuke Fujii, Yosuke Yamada, Shingo Oda

PERCEPTUAL AND MOTOR SKILLS　110　(3)　983-994　2010/06

DOI： 10.2466/PMS.110.3.983-994 　

ISSN： 0031-5125
Extracellular Water May Mask Actual Muscle Atrophy During Aging Peer-reviewed

Yosuke Yamada, Dale A. Schoeller, Eitaro Nakamura, Taketoshi Morimoto, Misaka Kimura, Shingo Oda

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES　65　(5)　510-516　2010/05

DOI： 10.1093/gerona/glq001 　

ISSN： 1079-5006
Reaction time to peripheral visual stimuli during exercise under hypoxia Peer-reviewed

Soichi Ando, Yosuke Yamada, Masahiro Kokubu

JOURNAL OF APPLIED PHYSIOLOGY　108　(5)　1210-1216　2010/05

DOI： 10.1152/japplphysiol.01115.2009 　

ISSN： 8750-7587
体肢の体水分量に月経周期が与える影響

松田かおり, 畑優樹, 秋山友美, 藤井真奈, 大前友里惠, 大林由佳, 榎本あや, 山田陽介, 走井裕香子, 大久保友香子, 眞鍋えみ子, 木村みさか

京都府立医科大学看護学科紀要　19　29-33　2010/03/05
Publisher:
ISSN： 1348-5962
Relationships between physical fitness and total body water in 378 community dwelling elderly persons

山縣恵美, 山田陽介, 小松光代

Bulletin of School of Nursing, Kyoto Prefectural University of Medicine　19　13-19　2010/03/05
Publisher: 京都府立医科大学医学部看護学科
ISSN： 1348-5962
CEREBRAL OXYGENATION OF CERVICAL SPINAL CORD INJURED INDIVIDUALS DURING LIGHT EXERCISE UNDER NORMOXIA AND HYPOXIA

TANAKA Toshiaki, YAMADA Yosuke, YOKOYAMA Keiichi, ANDO Soichi, YABE Kyonosuke

Japanese journal of physiological anthropology　14　(4)　157-162　2009/11/25
Publisher: 日本生理人類学会
DOI： 10.20718/jjpa.14.4_157 　

ISSN： 1342-3215

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The purpose of this study was to examine cerebral oxygenation in individuals with cervical spinal cord injury (SCI) during light exercise under normoxia and hypoxia. We used near-infrared spectroscopy to measure changes in oxyhemoglobin (oxyHb), deoxyhemoglobin (deoxyHb), and total hemoglobin (totalHb). In both the SCI and Control groups, deoxyHb increased during exercise under normoxia and hypoxia relative to rest. OxyHb slightly increased during exercise in the Control group. However, oxyHb decreased during exercise under hypoxia in the SCI group. These results might come from the decreased oxygen delivering capacity in individuals with SCI which was likely to result from the autonomic nervous system dysfunction and decreased skeletal muscle pump activity, possibly due to disuse atrophy.
Proximal electrode placement improves the estimation of body composition in obese and lean elderly during segmental bioelectrical impedance analysis Peer-reviewed

Yosuke Yamada, Yoshihisa Masuo, Keiichi Yokoyama, Yukako Hashii, Soichi Ando, Yasuko Okayama, Taketoshi Morimoto, Misaka Kimura, Shingo Oda

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY　107　(2)　135-144　2009/09

DOI： 10.1007/s00421-009-1106-6 　

ISSN： 1439-6319
身体組成とエネルギー消費量のより精確な簡便法とその応用--二重標識水(DLW)法を用いた検証

山田陽介

ランニング学研究　21　(1)　1-9　2009/06
Publisher: ランニング学会
ISSN： 0919-4312
Reaction time to peripheral visual stimuli during exercise under normoxia and hyperoxia Peer-reviewed

Soichi Ando, Yosuke Yamada, Toshiaki Tanaka, Shingo Oda, Masahiro Kokubu

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY　106　(1)　61-69　2009/05

DOI： 10.1007/s00421-009-0989-6 　

ISSN： 1439-6319
The Autonomic Nervous System Activity and Aging in Patients with Schizophrenia

藤林真美, 岸田郁子, 木村哲也, 山田陽介, 田中斉太郎, 石井千恵, 石井紀夫, 森谷敏夫

精神医学　51　(4)　315-323　2009/04/15

DOI： 10.11477/mf.1405101396 　

ISSN： 0488-1281
Light-intensity activities are important for estimating physical activity energy expenditure using uniaxial and triaxial accelerometers Peer-reviewed

Yosuke Yamada, Keiichi Yokoyama, Risa Noriyasu, Tomoaki Osaki, Tetsuji Adachi, Aya Itoi, Yoshihiko Naito, Taketoshi Morimoto, Misaka Kimura, Shingo Oda

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY　105　(1)　141-152　2009/01

DOI： 10.1007/s00421-008-0883-7 　

ISSN： 1439-6319
身体活動の測定児童における高強度身体活動の重要性―二重標識水法を用いた検討―

中江悟司, 山田陽介, 木村みさか, 鈴木和弘, 小澤治夫, 石井好二郎

日本体育協会スポーツ科学研究報告集　2007　II,18-21-21　2008/03/31
Intra‐ and Extra‐cellular Water Distribution in the Limbs after Cervical Spinal Cord Injury

田中利明, 山田陽介, 大畑光司, 矢部京之助

日本運動生理学雑誌　15　(1)　11-17　2008/02/29
Publisher: 日本運動生理学会
ISSN： 1340-3036

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People with cervical spinal cord injury (SCI) have motor and sensory dysfunction in the upper limbs as well as in the lower limbs (quadriplegia) and high risk of cardiovascular diseases. Muscle atrophy occurred with motor dysfunction induces accelerated catabolism of muscle cell protein and may alter distribution of body fluid. We examined intra-cellular water (ICW), extra-cellular water (ECW), and skeletal muscle mass of eight male with cervical-6th SCI (SCI; age, 34.1±2.4 yr, mean ± SE) and eight healthy age-, height-, waist circumference-matched male controls (CON). In results, ECW divid...
Limb muscle mass decrease with aging in Japanese men and women aged 15-97 yr

Yosuke Yamada, Misaka Kimura, Eitaro Nakamura, Yoshihisa Masuo, Shingo Oda

JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE　56　(5)　461-471　2007/10

DOI： 10.7600/jspfsm.56.461 　

ISSN： 0039-906X
Measuring energy expenditure and physical activity in elderly. Peer-reviewed

Yosuke Yamada, Keiichi Yokoyama, Taketoshi Morimoto, Shingo Oda, Misaka Kimura

JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE　56　(1)　31-31　2007/02

ISSN： 0039-906X

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Misc. 288

骨格筋超音波エコー輝度とDixon法による筋内脂肪割合との関連超音波撮像におけるフォーカス位置の違いによる検討

福元喜啓, 福元喜啓, 谷口匡史, 八木優英, 廣野哲也, 廣野哲也, 山縣桃子, 山縣桃子, 山縣桃子, 中井隆介, 山田陽介, 山田陽介, 木村みさか, 木村みさか, 池添冬芽, 市橋則明

日本理学療法学術大会(Web)　55th　2021
細胞外・細胞内水分比と年齢,性差,握力および身体活動との関連:J-MICC study SAGA

岩坂知治, 岩坂知治, 山田陽介, 西田裕一郎, 原めぐみ, 安方惇, 三好伸幸, 島ノ江千里, 南里妃名子, 古川拓馬, 古賀佳代子, 檜垣靖樹, 田中恵太郎

日本サルコペニア・フレイル学会誌　5　(Supplement)　2021

ISSN： 2433-1805
Evaluation of fat-free mass hydration in athletes and non-athletes. International-journal

Hiroyuki Sagayama, Yosuke Yamada, Mamiko Ichikawa, Emi Kondo, Jun Yasukata, Yoko Tanabe, Yasuki Higaki, Hideyuki Takahashi

European journal of applied physiology　120　(5)　1179-1188　2020/04/01

DOI： 10.1007/s00421-020-04356-y 　

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PURPOSE: To evaluate the hydration of fat-free mass (FFM) in athletes and non-athletes. METHODS: We analyzed the data of 128 healthy young adults (athletes: 61 men, 36 women; non-athletes: 19 men, 12 women) using the two-component (2C), 3C and 4C models. Under-water weighing or air-displacement plethysmography and deuterium dilution methods were used for estimating body density and total body water, respectively. The bone mineral content (BMC) was determined using whole-body scans by dual-energy X-ray absorptiometry. RESULTS: There was no significant difference in FFM hydration between the athletes (men, 72.3 ± 1.3%; women, 71.8 ± 1.3%) and non-athletes (men, 72.1 ± 1.2%; women, 72.2% ± 1.0%) in the 3C model. The total mean FFM hydration (72.1% ± 1.3%) was similar to the corresponding value in the literature (~ 73%). The estimation error of the percentage fat by the 2C vs the 4C model was significantly and highly correlated with hydration (r = 0.96), BMC (r = - 0.70), and total body protein (r = - 0.86) in the 4C model FFM. CONCLUSION: Although FFM hydration was similar in athletes and non-athletes, it would be underestimated or overestimated when the 2C model is used for evaluation, and the biological FFM hydration value deviates from the 73% value inter-individually. Despite that this inter-individual variation in FFM hydration is low in terms of between-individual standard deviation (1.3%), the BMC and total body protein differ greatly in athletes, and when it affects FFM hydration, it may also affect the percentage fat measurement in the 2C model. Thus, FFM hydration would not be affected by FFM, percent body fat, or the athletic status.
Bone mineral density in male weight-classified athletes is higher than that in male endurance-athletes and non-athletes. International-journal

Hiroyuki Sagayama, Emi Kondo, Yoko Tanabe, Takahiro Ohnishi, Yosuke Yamada, Hideyuki Takahashi

Clinical nutrition ESPEN　36　106-110　2020/04

DOI： 10.1016/j.clnesp.2020.01.008 　

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BACKGROUND: Weight-bearing physical activity and intense mechanical stimuli affect the bone through the endocrine system; hence, bone-loading sports affect bone mineral density. We hypothesized that weight-classified athletes, such as those practicing wrestling and judo, have relatively high bone mineral density because these activities have a higher impact on the entire body during daily training compared to low- or non-impact activities. We aimed to investigate the bone mineral density of weight-classified athletes (participating in wrestling and judo) to compare the parameters with those of endurance-athletes and non-athletes. METHODS: Thirty-three college athletes (aged 18-22 years) were divided into three groups, wrestlers, judoka, and endurance-athletes, according to their sports history. Eight non-athletes participated as controls. Bone mineral density was determined by whole-body dual-energy X-ray absorptiometry. RESULTS: Mean whole-body bone mineral density of wrestlers and judoka was higher than that of endurance-athletes and non-athletes (P < 0.01). The bone mineral density of athletes competing in wrestling and judo was higher than that of non-athletes when adjusted for body mass. CONCLUSIONS: The present study demonstrated that weight-classified athletes have significantly higher bone mineral density compared to endurance- and non-athletes, despite rapid weight loss before competitions.
糖尿病診療ガイドライン2019に基づいた食事療法を検証するCLEVER-DM研究より

宮澤伊都子, 森野勝太郎, 中川恵子, 近藤慶子, 大井彰子, 西田香, 栗原美香, 中西直子, 西田優紀, 中江悟司, 山田陽介, 田中茂穂, 海老根直之, 佐々木敏, 勝川史憲, 佐々木雅也, 卯木智, 前川聡

糖尿病(Web)　63　(Suppl)　2020

ISSN： 1881-588X
尿中cortisol/cortisone比と精神健康との関連:J-MICC study SAGA

島ノ江千里, 島ノ江千里, 松本明子, 赤尾千穂, 原めぐみ, 西田裕一郎, 南里妃名子, 堀田美加子, 山田陽介, 檜垣靖樹, 田中恵太郎

日本疫学会学術総会講演集(Web)　30th　2020
日本医療研究開発機構(AMED)が推進する糖尿病研究の展開介護施設居住者、COPD、糖尿病患者におけるエネルギーバランスについての研究(Studies on energy balance in nursing home residents, patients with COPD and diabetes)

勝川史憲, 森野勝太郎, 卯木智, 前川聡, 近藤慶子, 西田香, 大井彰子, 栗原美香, 佐々木雅也, 中江悟司, 西田優紀, 山田陽介, 田中茂穂, 海老根直之, 佐々木敏

糖尿病　62　(Suppl.1)　S-27　2019/04
Publisher: (一社)日本糖尿病学会
ISSN： 0021-437X

eISSN： 1881-588X
Studies on energy balance in nursing home residents, patients with COPD and diabetes

勝川史憲, 森野勝太郎, 卯木智, 前川聡, 近藤慶子, 西田香, 大井彰子, 栗原美香, 佐々木雅也, 中江悟司, 西田優紀, 山田陽介, 田中茂穂, 海老根直之, 佐々木敏

糖尿病(Web)　62　(Suppl)　2019

ISSN： 1881-588X
Comparison of basal metabolic rate between paraplegia athletes and non-athletes

MOTONAGA Keiko, YAMADA Yosuke, YOSHIDA Tsukasa, KONDO Emi, NAKAGATA Takashi, NAKAGATA Takashi, SAGAYAMA Hiroyuki, YOSHINO Masae, HAKAMADA Noriko, YAMAMOTO Maho, TAKAHASHI Hideyuki, HANGAI Mika, OGATA Toru

Journal of Physical Fitness and Sports Medicine　8　(6)　2019

ISSN： 2186-8131
The ECW/ICW ratio can evaluate muscle swelling after resistance training. Peer-reviewed

Taniguchi M, Yamada Y, Ikezoe T, Ichihashi N

The 23th Annual Congress of the European College of Sport Science.　2018/07
主要研究（2）体重階級制競技における減量後の最適なリカバリーに関する研究

髙橋英幸, 近藤衣美, 山下大地, 西牧未央, 石井泰光, 亀井明子, 元永恵子, 岩山海渡, 中嶋耕平, 大西貴弘, 下山寛之, 塩瀬圭佑, 檜垣靖樹, 田中宏暁, 山田陽介, 岡村浩嗣, 海老根直之

国立スポーツ科学センター年報2017　17　49　2018/06
5年間の精神ストレスとCRPの関連は,対処行動や社会的支援の変化により異なる

島ノ江千里, 原めぐみ, 西田裕一郎, 南里妃名子, 安方惇, 三好信行, 山田陽介, 桧垣靖樹, 田中恵太郎

日本衛生学雑誌(Web)　73　(Supplement)　S228　2018/03

ISSN： 1882-6482
日常身体活動とPYCARD遺伝子メチル化の縦断的関連

西田裕一郎, 原めぐみ, 桧垣靖樹, 田口尚人, 島ノ江千里, 南里妃名子, 中村和代, 今泉猛, 坂本龍彦, 安方惇, 三好伸幸, 山田陽介, 堀田美加子, 東元健, 副島英伸, 新地浩一, 田中恵太郎

日本疫学会学術総会講演集(Web)　28th　132 (WEB ONLY)　2018/02/01
糖尿病患者の身体活動量の特徴と体組成,体格との関係:日本人の食事摂取基準2020年版に向けて

宮澤伊都子, 森野勝太郎, 布施恵子, 近藤慶子, 大井彰子, 西田香, 栗原美香, 安原祥子, 中西直子, 西田優紀, 中江悟司, 山田陽介, 田中茂穂, 海老根直之, 佐々木敏, 勝川史憲, 佐々木雅也, 卯木智, 前川聡

糖尿病(Web)　61　(Suppl)　2018

ISSN： 1881-588X
Energy Expenditure In Low-load Resistance Exercise With Slow Movement Using Body Mass Alone As Load

Takashi Nakagata, Yosuke Yamada, Hisashi Naito

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE　49　(5)　923-923　2017/05

DOI： 10.1249/01.mss.0000519508.74692.e0 　

ISSN： 0195-9131

eISSN： 1530-0315
高齢者の膝伸展筋力に骨格筋の質的変化が及ぼす影響筋輝度だけでなく骨格筋細胞外液比が関連する

谷口匡史, 山田陽介, 福元喜啓, 澤野翔一朗, 池添冬芽, 渡邊裕也, 木村みさか, 市橋則明

理学療法学　44　(Suppl.2)　O-4　2017/04
Publisher: (公社)日本理学療法士協会
ISSN： 0289-3770

eISSN： 2189-602X
高齢者の膝伸展筋力に骨格筋の質的変化が及ぼす影響筋輝度だけでなく骨格筋細胞外液比が関連する

谷口匡史, 山田陽介, 福元喜啓, 澤野翔一朗, 池添冬芽, 渡邊裕也, 木村みさか, 市橋則明

理学療法学　44　(Suppl.2)　O-KS　2017/04
Publisher: (公社)日本理学療法士協会
DOI： 10.14900/cjpt.2016.0427 　

ISSN： 0289-3770
精神ストレスと睡眠の質の関連における情緒的支援の影響は,就業状況によって異なる

島ノ江千里, 原めぐみ, 西田裕一郎, 南里妃名子, 安方淳, 山田陽介, 桧垣靖樹, 田中恵太郎

日本行動医学会学術総会プログラム・抄録集　23rd　70　2017/03/17
精神ストレスと睡眠の関連におけるストレス防御因子(社会的支援・対処行動)の影響:J‐MICC study SAGA

島ノ江千里, 原めぐみ, 西田裕一郎, 南里妃名子, 安方淳, 山田陽介, 桧垣靖樹, 田中恵太郎

日本疫学会学術総会講演集(Web)　27th　125 (WEB ONLY)　2017/01/25
高齢者における野菜・果物摂取頻度と口腔関連QOLとの関連:Kyoto‐Kameoka Study

南里妃名子, 山田陽介, 糸井亜弥, 渡邊裕也, 横山慶一, 吉田司, 吉村英一, 白澤貴子, 落合裕隆, 後藤千穂, 高田和子, 小風暁, 木村みさか

日本公衆衛生学会総会抄録集　75th　639-639　2016/10/15
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
中高生野球選手における投球障害と関節可動域・筋力・質問紙の関係

幸田仁志, 幸田仁志, 来田宣幸, 松井知之, 甲斐義浩, 東善一, 平本真知子, 瀬尾和弥, 宮崎哲哉, 江藤寿明, 山田陽介, 森原徹

日本臨床スポーツ医学会誌　24　(4)　S277-S277　2016/10/01
Publisher: (一社)日本臨床スポーツ医学会
ISSN： 1346-4159
肩肘の投球障害をスクリーニングする質問紙の開発

来田宣幸, 幸田仁志, 甲斐義浩, 松井知之, 東善一, 平本真知子, 瀬尾和弥, 宮崎哲哉, 江藤寿明, 山田陽介, 渡邊裕也, 森原徹

日本臨床スポーツ医学会誌　24　(4)　S305-S305　2016/10/01
Publisher: (一社)日本臨床スポーツ医学会
ISSN： 1346-4159
投球動作と関節可動域および新しい下肢・体幹複合評価との関連性について

松井知之, 森原徹, 瀬尾和弥, 東善一, 平本真知子, 来田宣幸, 宮崎哲哉, 甲斐義浩, 幸田仁志, 江藤寿明, 山田陽介, 盛房周平

日本臨床スポーツ医学会誌　24　(4)　S259-S259　2016/10/01
Publisher: (一社)日本臨床スポーツ医学会
ISSN： 1346-4159
投手の球速に関連する因子の検討

平本真知子, 森原徹, 松井知之, 東善一, 瀬尾和弥, 宮崎哲哉, 渡邊裕也, 山田陽介, 来田宣幸, 盛房周平

日本臨床スポーツ医学会誌　24　(4)　S306　2016/10/01

ISSN： 1346-4159
Intensity and Bouts of Physical Activity and Physical Activity Level in Pre-adolescent Children

Keisuke Komura, Satoshi Nakae, Kazufumi Hirakawa, Naoyuki Ebine, Kazuhiro Suzuki, Haruo Ozawa, Yosuke Yamada, Misaka Kimura, Kojiro Ishii

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE　48　(5)　374-374　2016/05

DOI： 10.1249/01.mss.0000486132.51384.13 　

ISSN： 0195-9131

eISSN： 1530-0315
Thoracic Gas Volume Changes after Weight Loss and Regain Associated with Body-Fat Measurement in Wrestlers

Emi Kondo, Keisuke Shiose, Keiko Motonaga, Takuya Osawa, Hiroyuki Sagayama, Yosuke Yamada, Kohei Nakajima, Akiko Kamei, Hideyuki Takahashi

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE　48　(5)　552-552　2016/05

DOI： 10.1249/01.mss.0000486659.10976.05 　

ISSN： 0195-9131

eISSN： 1530-0315
Validation of Physical Activity Estimated Using Wearable Devices under Free-living Conditions

Haruka Murakami, Ryoko Kawakami, Satoshi Nakae, Yosuke Yamada, Yoshio Nakata, Kazuko Ishikawa-Takata, Shigeho Tanaka, Motohiko Miyachi

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE　48　(5)　550-550　2016/05

DOI： 10.1249/01.mss.0000486651.95728.2e 　

ISSN： 0195-9131

eISSN： 1530-0315
高齢者における緑茶およびコーヒー摂取頻度と口腔関連QOLとの関連―Kyoto‐Kameoka Study

南里妃名子, 山田陽介, 渡邊裕也, 三宅基子, 横山慶一, 山縣恵美, 白澤貴子, 落合裕隆, 糸井亜弥, 吉田司, 伊達平和, 菊谷武, 吉田光由, 後藤千穂, 高田和子, 小風暁, 木村みさか

Journal of Epidemiology (Web)　26　(Supplement 1)　111　2016/01/21

ISSN： 0917-5040
長期的な自覚ストレスとDNA酸化損傷(尿中8OHdG)との関連は抑うつの高さによって異なる:J‐MICC study SAGA

島ノ江千里, 原めぐみ, 西田裕一郎, 大塚康子, 南里妃名子, 堀田美加子, 安方淳, 三好信行, 山田陽介, LI Yun‐Shan, 河井一明, 葛西宏, 桧垣靖樹, 田中恵太郎

Journal of Epidemiology (Web)　26　(Supplement 1)　100　2016/01/21

ISSN： 0917-5040
長期的な自覚ストレスとDNA酸化損傷(尿中8OHdG)との関連は抑うつの高さによって異なる:J-MICC study SAGA

島ノ江千里, 原めぐみ, 西田裕一郎, 大塚康子, 南里妃名子, 堀田美加子, 安方淳, 三好信行, 山田陽介, LI Yun-Shan, 河井一明, 葛西宏, 桧垣靖樹, 田中恵太郎

Journal of Epidemiology (Web)　26　(Supplement 1)　2016

ISSN： 1349-9092
14介−26−口−10 高齢者における足関節底屈筋力と立位バランス能力の関係

江間諒一, 髙山浩一, 山田陽介, 赤木亮太

日本体育学会大会予稿集　67　(0)　351_1-351_1　2016
Publisher: 一般社団法人日本体育学会

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 転倒をもたらす要因として、足関節底屈筋力およびバランス能力の低下が指摘されているが、両者の関係性は不明瞭である。本研究は、高齢者における足関節底屈筋力と立位バランス能力の関連を検討した。65歳以上の健常男性43名および女性35名が、等尺性足関節底屈筋力をできるだけ速く全力で発揮した。得られた時間‐トルク波形を用いて、底屈トルクのピーク値およびトルクを発揮してから100ミリ秒経過した際の底屈トルクを算出した。立位バランス能力の指標として、30秒間の開眼片足立ち実施時における足圧中心の軌跡長を求めた。その結果、男性において、100ミリ秒経過した際の足関節底屈トルクと足圧中心の軌跡長との間に有意な負の相関関係がみられたが、女性においてはみられなかった。一方、性別によらず、底屈トルクのピーク値と足圧中心の軌跡長との間に有意な相関関係は観察されなかった。以上の結果は、特に男性において、足関節底屈における最大筋力よりも瞬発的な筋力がバランス能力と関係することを示唆している。足関節底屈における瞬発的な筋力発揮能力を高めることで、高齢男性ではバランス能力の改善も期待されるが、高齢女性においては難しい可能性がある。
14介−26−ポ−05 地域在住高齢者の認知機能と体力の関係:亀岡スタディ

吉田司, 木村みさか, 山田陽介, 来田宣幸, 野村照夫

日本体育学会大会予稿集　67　(0)　353_2-353_2　2016
Publisher: 一般社団法人日本体育学会

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 高齢者の認知機能と体力の関係を明らかにすることを目的とした。対象者は、2011年に実施した日常生活圏域ニーズ調査の認知機能尺度（CPS）の評価が可能で、教育年数に欠損がなく、2012年の体力測定会で10m歩行、ファンクショナルリーチ、開眼片足立ち、垂直跳、握力を完遂した65歳以上の自立高齢者1084人（平均73.3歳）である。CPSは介護認定に係る主治医意見書からでも評価でき、認知症ケアパスの作成に利用される。体力5項目はFitness Age Score（FAS）で得点化し、CPSレベル（0、1、2以上）による3群間比較を年齢と教育年数を調整したANCOVAによって行い、Jonckheere-Terpstra検定によって傾向性を確認した。FASはCPS0が－0.49、CPS1が－0.93、CPS2以上が－1.20で、年齢と教育年数を調整してもCPS0はCPS1より有意に高かった。また、CPSレベルが高くなるに従いFASが有意に低下した。結果は体力と認知機能の因果関係を証明するものではないが、体力に関与する生活習慣など要因が認知機能に影響している可能性が考えられる。
311）地域高齢者の閉じこもりと孤独感との関連

山縣恵美, 小松光代, 木村みさか, 山田陽介, 桝本妙子, 續田尚美, 杉原百合子, 岡山寧子

日本看護研究学会雑誌　39　(3)　296-296　2016
Publisher: 一般社団法人日本看護研究学会
ISSN： 2188-3599
投手における投球側下肢の力学的特徴

松井知之, 森原徹, 瀬尾和弥, 東善一, 平本真知子, 来田宣幸, 山田陽介, 甲斐義浩, 竹本裕樹, 三上靖夫, 盛房周平, 久保俊一

体力科学　64　(6)　713　2015/12/01

ISSN： 0039-906X
短期間の急速減量プログラムはアスリートの走パフォーマンスを向上させるか

渡口槙子, 山崎郁美, 下山寛之, 山田陽介, 海老根直之, 布目寛幸, 檜垣靖樹, 清永明, 田中宏暁

体力科学　64　(6)　598　2015/12/01

ISSN： 0039-906X
筋グリコーゲン濃度増加時の体水分動態―重水希釈法および生体電気インピーダンス分光法による検討―

塩瀬圭佑, 元永恵子, 下山寛之, 山田陽介, 桧垣靖樹, 田中宏暁, 高橋英幸

体力科学　64　(6)　591　2015/12/01

DOI： 10.7600/jspfsm.64.591 　

ISSN： 0039-906X
質問紙によるフレイル判定とその後の要介護認定の関係

吉田司, 吉田司, 山田陽介, 山田陽介, 渡邊裕也, 渡邊裕也, 三宅基子, 三宅基子, 山田実, 山田実, 木村みさか, 木村みさか

体力科学　64　(6)　625-625　2015/12/01
Publisher: (一社)日本体力医学会
ISSN： 0039-906X

eISSN： 1881-4751
保育園児の身体活動量および体格・体力(幼稚園児との比較)

青木好子, 渡邊裕也, 渡邊裕也, 山田陽介, 木村みさか

体力科学　64　(6)　617　2015/12/01

ISSN： 0039-906X
WEBを用いた身体活動測定システムの平日と休日の妥当性の比較

難波秀行, 黒坂裕香, 湊久美子, 山田陽介, 木村みさか

体力科学　64　(6)　680　2015/12/01

ISSN： 0039-906X
地域高齢者の有酸素能と脳萎縮の関係

古瀬裕次郎, 池永昌弘, 森村和浩, 山田陽介, 武田典子, 三好伸幸, 清永明, 田中宏暁, 田中宏暁, 桧垣靖樹

体力科学　64　(6)　632　2015/12/01

ISSN： 0039-906X
ICP‐MSによる細胞内外液測定の妥当性

山田陽介, 山田陽介, 走井裕香子, 安藤創一, 糸井亜弥, 吉川豊, 安井裕之, 森本武利, 木村みさか

体力科学　64　(6)　672-672　2015/12/01
Publisher: (一社)日本体力医学会
ISSN： 0039-906X

eISSN： 1881-4751
亀岡スタディベースライン体力調査参加者のフレイル出現率と体力

木村みさか, 吉田司, 山田陽介, 山田実, 渡邊ゆうや, 三宅基子

体力科学　64　(6)　625-625　2015/12/01
Publisher: (一社)日本体力医学会
ISSN： 0039-906X

eISSN： 1881-4751
5年間の自覚ストレスとDNA損傷マーカー(8OHdG)との関連;J‐MICC study SAGA

島ノ江千里, 原めぐみ, 西田裕一郎, 大塚康子, 南里妃名子, 堀田美加子, 安方淳, 三好信行, 山田陽介, LI Yun‐Shan, 河井一明, 葛西宏, 桧垣靖樹, 田中恵太郎

日本行動医学会学術総会プログラム・抄録集　22nd　50　2015/10/16
地域高齢者の散歩行動に影響を及ぼすソーシャルキャピタル要因に関する研究

三宅基子, 渡邊裕也, 山田陽介, 山縣恵美, 桝本妙子, 岡山寧子, 木村みさか

日本公衆衛生学会総会抄録集　74th　402　2015/10/15

ISSN： 1347-8060
フレイル判定法と該当者数(亀岡スタディベースライン体力調査参知者での検討)

木村みさか, 吉田司, 山田陽介, 渡邊裕也, 山縣恵美, 横山慶一, 三宅基子, 吉中康子, 高田和子, 石原達朗, 海老根直之, 山田実, 中谷友樹, 岡山寧子, 桝本妙子

日本公衆衛生学会総会抄録集　74th　364　2015/10/15

ISSN： 1347-8060
地域在住自立高齢者の転倒リスクと体力との関連

桝本妙子, 山田陽介, 渡邊裕也, 山縣恵美, 吉田司, 横山慶一, 三宅基子, 吉中康子, 高田和子, 石原達朗, 海老根直之, 山田実, 中谷友樹, 岡山寧子, 木村みさか

日本公衆衛生学会総会抄録集　74th　364　2015/10/15

ISSN： 1347-8060
体力科学的アプローチによる認知症とサルコペニア予防の縦断研究―福岡那珂川研究―至適運動強度を用いた有酸素性トレーニングの可能性―

森村和浩, 池永昌弘, 山田陽介, 武田典子, 三好伸幸, 古瀬裕次郎, 町田由紀子, 栗山緑, 寺田久子, 木村みさか, 檜垣靖樹, 檜垣靖樹, 田中宏暁, 田中宏暁

月刊臨床と研究　92　(9)　1232-1233　2015/09/20

ISSN： 0021-4965
ヘルスツーリズムによる短期間の減量効果の検証

渡口槙子, 下山寛之, 静間佳代子, 町田由紀子, 青柳遼, 水原博而, 山田陽介, 海老根直之, 檜垣靖樹, 田中宏暁

肥満研究　21　(Supplement)　146　2015/09/08

ISSN： 1343-229X
褐色脂肪組織は日常生活中のエネルギー消費量増大に貢献するのか

中江悟司, 中江悟司, 米代武司, 松下真美, 山田陽介, 高田和子, 斉藤昌之, 田中茂穂

肥満研究　21　(Supplement)　174-174　2015/09/08
Publisher: (一社)日本肥満学会
ISSN： 1343-229X
小児における身体活動レベル別の身体活動量―二重標識水法および加速度計法を用いた検討―

香村恵介, 香村恵介, 中江悟司, 平川和文, 海老根直之, 鈴木和弘, 小澤治夫, 山田陽介, 木村みさか, 石井好二郎

日本未病システム学会学術総会抄録集　22回　112-112　2015/09
Publisher: (一社)日本未病システム学会
ISSN： 1347-9083
高齢者の閉じこもり予防支援に関する国内外の研究動向

山縣恵美, 木村みさか, 山田陽介, 小松光代, 杉原百合子, 岡山寧子

日本看護研究学会雑誌(CD-ROM)　38　(3)　ROMBUNNO.354　2015/07/22

ISSN： 2188-3599
日常生活の歩数が地域在住高齢者の骨格筋量および質に及ぼす影響

渡邊裕也, 山田陽介, 横山慶一, 吉田司, 三宅基子, 山縣恵美, 岡山寧子, 吉中康子, 木村みさか

日本老年医学会雑誌　52　85　2015/05/25

ISSN： 0300-9173
高齢者における主観的体力とその影響要因の検討

木村みさか, 岡山寧子, 渡邊裕也, 山縣恵美, 三宅基子, 吉田司, 山田陽介

日本老年医学会雑誌　52　100　2015/05/25

ISSN： 0300-9173
Body Water Status and Muscle Glycogen Recovery: Effect of Different Amounts of Carbohydrate Intake

Keisuke Shiose, Takuya Osawa, Keiko Motonaga, Emi Kondo, Akiko Kamei, Takashi Kawahara, Motoko Taguchi, Yosuke Yamada, Hideyuki Takahashi

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE　47　(5)　869-869　2015/05

DOI： 10.1249/01.mss.0000479086.59817.60 　

ISSN： 0195-9131

eISSN： 1530-0315
Muscular endurance and blood flow of the tibialis anterior muscle in university soccer players

Ikenaga Masahiro, Ikota Takeo, Hirano Masami, Morimura Kazuhiro, Yamada Yosuke, Shindo Munehiro, Kiyonaga Akira

Fukuoka University review of sports and health science　45　(2)　35-42　2015/03
Publisher: Fukuoka University
ISSN： 1345-9244
都市部幼稚園児における身体活動量(強度別活動時間)と体力との関連

青木好子, 山田陽介, 渡邊裕也, 木村みさか

日本発育発達学会大会抄録集　13th　75　2015/02/18
子どもの継続した中高強度身体活動と身体活動レベルとの関係

香村恵介, 中江悟司, 平川和文, 鈴木和弘, 小澤治夫, 木村みさか, 山田陽介, 川勝佐希, 石井好二郎

日本発育発達学会大会抄録集　13th　43　2015/02/18
筋グリコーゲン量と細胞内外液量の関連性の検討

塩瀬圭佑, 山田陽介, 山田陽介, 山田陽介, 上野誠也, 青柳遼, 飛奈卓郎, 飛奈卓郎, 三好伸幸, 桧垣靖樹, 桧垣靖樹, 清永明, 清永明, 田中宏暁, 田中宏暁

ランニング学研究　26　(1)　101‐102　2015/02/02

ISSN： 0919-4312
高齢者の廃用性筋萎縮の早期発見と予防プログラムの効果検証

山田陽介, 渡邊裕也, 池永昌弘, 木村みさか

体力科学　64　(1)　72-72　2015/02/01
Publisher: 一般社団法人日本体力医学会
DOI： 10.7600/jspfsm.64.72 　

ISSN： 0039-906X
保育園児における身体活動量(強度別活動時間)と体力との関連

青木好子, 山田陽介, 木村みさか

日本体育学会大会予稿集　66th　248　2015
身体活動の標準的な評価法の開発に関する研究ヒューマンカロリメーターを用いたメッツ表の妥当性の検討

田中茂穂, 中江悟司, 山田陽介

身体活動の標準的な評価法の開発に関する研究平成26年度総括研究報告書　21‐24　2015
生活習慣病予防や身体機能維持のためのエネルギー・たんぱく質必要量の推定法に関する基盤的研究自立した高齢者におけるエネルギー消費量および身体活動レベル

田中茂穂, 高田和子, 吉田英世, 佐々木敏, 山田陽介, 中江悟司

生活習慣病予防や身体機能維持のためのエネルギー・たんぱく質必要量の推定法に関する基盤的研究平成26年度総括・分担研究報告書　7‐12　2015
身体活動の標準的な評価法の開発に関する研究活動量計やライフログによる身体活動量推定法の互換性に関する研究―15日間の自由生活における検討~

村上晴香, 川上諒子, 田中茂穂, 高田和子, 中江悟司, 山田陽介, 宮地元彦

身体活動の標準的な評価法の開発に関する研究平成26年度総括研究報告書　9‐13　2015
高齢者の廃用性筋萎縮の早期発見と予防プログラムの効果検証

山田陽介, 渡邊裕也, 池永昌弘, 木村みさか

体力科学　64　(1)　72-72　2015
Publisher: 一般社団法人日本体力医学会
ISSN： 0039-906X
354）高齢者の閉じこもり予防支援に関する国内外の研究動向

山縣恵美, 木村みさか, 山田陽介, 小松光代, 杉原百合子, 岡山寧子

日本看護研究学会雑誌　38　(3)　3_314-3_314　2015
Publisher: 一般社団法人日本看護研究学会
ISSN： 2188-3599
投手に対する下肢・体幹複合機能評価の開発

松井知之, 森原徹, 平本真知子, 東善一, 瀬尾和弥, 来田宣幸, 山田陽介, 三浦雄一郎, 吉田司, 木田圭重, 池田巧, 堀井基行, 久保俊一

体力科学　63　(6)　713-713　2014/12/01
Publisher: (一社)日本体力医学会
ISSN： 0039-906X

eISSN： 1881-4751
高齢者における体力変化量と転倒との関連(毎年継続実施している体力測定会へ5年から9年間参加している者での解析)

木村みさか, 山田陽介

体力科学　63　(6)　629　2014/12/01

ISSN： 0039-906X
女子プロ野球選手の身体的・体力的特性

来田宣幸, 神谷将志, 谷川哲郎, 山田陽介, 三浦雄一郎, 松井知之, 森原徹

体力科学　63　(6)　732　2014/12/01

ISSN： 0039-906X
グリコーゲンローディング時における筋グリコーゲン濃度と体水分量の関連―多周波生体電気インピーダンス法を用いた検討―

塩瀬圭佑, 元永恵子, 山田陽介, 高橋英幸

体力科学　63　(6)　594　2014/12/01

ISSN： 0039-906X
女子プロ野球投手の投球動作解析―骨盤・胸郭運動と球速との関連―

東善一, 森原徹, 松井知之, 瀬尾和弥, 平本真知子, 来田宣幸, 山田陽介, 渡邊裕也, 島津昭人, 池田巧, 堀井基行, 久保俊一

体力科学　63　(6)　694　2014/12/01

ISSN： 0039-906X
女子学生のボディイメージが食事記録調査の精確性に与える影響

糸井亜弥, 山田陽介, 木村みさか

体力科学　63　(6)　685　2014/12/01

ISSN： 0039-906X
身体活動分析システムによる小学生とその親の身体活動の関連

難波秀行, 山田陽介, 木村みさか

体力科学　63　(6)　665　2014/12/01

ISSN： 0039-906X
介護予防を目的とした運動介入が高齢者の筋内組成に及ぼす効果

渡邊裕也, 山田陽介, 吉田司, 横山慶一, 三宅基子, 木村みさか

体力科学　63　(6)　653　2014/12/01

ISSN： 0039-906X
大学卓球選手のエネルギー消費量に関する研究

下山寛之, 浜口元樹, 畑本陽一, 西村紗奈, 山田陽介, 安方惇, 市川麻美子, 海老根直之, 清永明, 桧垣靖樹, 田中宏暁

体力科学　63　(6)　611　2014/12/01

DOI： 10.7600/jspfsm.63.611 　

ISSN： 0039-906X
地域高齢者を対象とした体力科学的アプローチによる認知症とサルコペニア予防の縦断研究―福岡那珂川研究―認知機能低下者への運動介入の効果

古瀬裕次郎, 池永昌弘, 森村和浩, 山田陽介, 武田典子, 三好伸幸, 栗山緑, 町田由紀子, 合馬慎二, 坪井義夫, 山田達夫, 木村みさか, 清永明, 田中宏暁, 桧垣靖樹

月刊臨床と研究　91　(11)　1534　2014/11/20

ISSN： 0021-4965
うつ傾向高齢者に対する運動を中心とした教室型介護予防プログラムの効果

山縣恵美, 木村みさか, 山田陽介, 桝本妙子, 小松光代, 杉原百合子, 岡山寧子

日本看護科学学会学術集会講演集　34th　561　2014/11
中高野球選手における体幹パワーとパフォーマンスの関係―MBスローとスイング速度を指標として―

神谷将志, 谷川哲朗, 来田宣幸, 野村照夫, 松井知之, 瀬尾和弥, 平本真知子, 東善一, 宮崎哲哉, 森原徹, 山田陽介, 三浦雄一郎, 福島秀晃

体育の科学　64　(11)　820-821　2014/11/01

ISSN： 0039-8985
地域在住「自立高齢者」の基本チェックリストの2年後の変化

桝本妙子, 山田陽介, 山縣恵美, 小松光代, 岡山寧子, 三宅基子, 木村みさか

日本公衆衛生学会総会抄録集　73rd　457　2014/10/15

ISSN： 1347-8060
亀岡スタディベースライン調査(体力)の特性

木村みさか, 三宅基子, 山田陽介, 岡山寧子, 山縣恵美, 桝本妙子

日本公衆衛生学会総会抄録集　73rd　457　2014/10/15

ISSN： 1347-8060
女子プロ野球選手における関節可動域の類型と障害との関係

平本真知子, 森原徹, 松井知之, 東善一, 瀬尾和弥, 宮崎哲哉, 祐成毅, 吉田司, 渡邊裕也, 山田陽介, 来田宣幸, 池田巧, 堀井基行, 久保俊一

日本臨床スポーツ医学会誌　22　(4)　S130-S130　2014/10/01
Publisher: (一社)日本臨床スポーツ医学会
ISSN： 1346-4159
高齢者のナトリウムならびにカリウム摂取量が安静時心電図補正QT間隔に及ぼす影響

道下竜馬, 高田和子, 吉村英一, 三原里佳子, 池永昌弘, 森村和浩, 武田典子, 山田陽介, 檜垣靖樹, 田中宏暁, 清永明

日本動脈硬化学会総会・学術集会プログラム・抄録集(Web)　46th　1-P-95 (WEB ONLY)　2014/06/25
生体電気インピーダンス法による部位別推定筋量を用いて野球選手のパフォーマンスを評価する方法の開発

山田勝真, 山田勝真, 大桐将, 大桐将, 成田智恵子, 松井知之, 山田陽介, 山田陽介, 三浦雄一郎, 森原徹, 森原徹, 来田宣幸, 濱田泰以

人間工学　50　(Supplement)　402‐403-S403　2014/06/05
Publisher: Japan Ergonomics Society
DOI： 10.5100/jje.50.s402 　

ISSN： 0549-4974

eISSN： 1884-2844
サルコペニア判定のための骨格筋量を計測する新たな方法の開発(亀岡Study)

山田陽介, 渡邊裕也, 横山慶一, 吉田司, 三宅基子, 山縣恵美, 吉中康子, 岡山寧子, 木村みさか

日本老年医学会雑誌　51　78　2014/05/12

ISSN： 0300-9173
地域在住高齢者の痛みの実態と体力との関連(亀岡Study)

木村みさか, 山縣恵美, 山田陽介, 三宅基子, 渡邊裕也, 横山慶一, 吉田司, 岡山寧子, 吉中康子, 桝本妙子

日本老年医学会雑誌　51　86-87　2014/05/12

ISSN： 0300-9173
地域の介護・サルコペニア予防におけるフォローアップの効果と意義―21カ月の大規模介入研究の結果から―(亀岡Study)

渡邊裕也, 山田陽介, 横山慶一, 吉田司, 三宅基子, 山縣恵美, 桝本妙子, 岡山寧子, 吉中康子, 木村みさか

日本老年医学会雑誌　51　110　2014/05/12

ISSN： 0300-9173
高齢者の身体活動量と安静時心電図補正QT間隔との関係

道下竜馬, 池永昌弘, 武田典子, 山田陽介, 桧垣靖樹, 田中宏暁, 清永明

日本老年医学会雑誌　51　107-108　2014/05/12

ISSN： 0300-9173
地域在住高齢者の口腔保健行動と体力の関係(亀岡Study)

横山慶一, 山田陽介, 三宅基子, 渡邊裕也, 吉田司, 山縣恵美, 桝本妙子, 吉中康子, 岡山寧子, 木村みさか

日本老年医学会雑誌　51　135　2014/05/12

DOI： 10.3143/geriatrics.51.135 　

ISSN： 0300-9173
地域在住自立高齢者の閉じこもり及び睡眠の実態と両者の関連

山縣恵美, 三宅基子, 木村みさか, 山田陽介, 桝本妙子, 渡邊裕也, 横山慶一, 吉田司, 吉中康子, 岡山寧子

日本老年医学会雑誌　51　56　2014/05/12

ISSN： 0300-9173
熱中症により救急搬送された高齢者の生活状況

岡山寧子, 山田陽介, 山縣恵美, 三宅基子, 渡邊裕也, 横山慶一, 吉田司, 桝本妙子, 吉中康子, 木村みさか

日本老年医学会雑誌　51　56　2014/05/12

ISSN： 0300-9173
亀岡スタディの研究デザインとベースラインの対象者特性―生活機能リスクと体力の実態とその関連―

三宅基子, 岡山寧子, 山田陽介, 桝本妙子, 横山慶一, 渡邊裕也, 吉田司, 吉中康子, 山縣恵美, 木村みさか

日本老年医学会雑誌　51　136　2014/05/12

ISSN： 0300-9173
軽費老人ホーム利用者における5年間の身体機能の変化

吉中康子, 渡邊裕也, 横山慶一, 三宅基子, 山田陽介, 吉田司, 山縣恵美, 桝本妙子, 岡山寧子, 木村みさか

日本老年医学会雑誌　51　136　2014/05/12

ISSN： 0300-9173
高齢者における筋力ならびに歩行速度と三軸加速度計による身体活動量の関係―福岡・那珂川スタディー

池永昌弘, 山田陽介, 武田典子, 木村みさか, 桧垣靖樹, 田中宏暁, 清永明

日本老年医学会雑誌　51　107　2014/05/12

ISSN： 0300-9173
地域在住自立高齢者の保健習慣と健康度との関連

桝本妙子, 山田陽介, 吉田司, 三宅基子, 渡邊裕也, 横山慶一, 山縣恵美, 吉中康子, 岡山寧子, 木村みさか

日本老年医学会雑誌　51　136　2014/05/12

ISSN： 0300-9173
地域在住高齢者の身体活動量(亀岡Study)

吉田司, 山田陽介, 三宅基子, 渡邊裕也, 横山慶一, 山縣恵美, 桝本妙子, 吉中康子, 岡山寧子, 木村みさか

日本老年医学会雑誌　51　86　2014/05/12

ISSN： 0300-9173
Bioelectrical Impedance Spectroscopy: A Reproducible Method of Muscle Mass Assessment

Yosuke Yamada, Bjoern Buehring, Diane Krueger, Neil Binkley, Dale Schoeller

JOURNAL OF BONE AND MINERAL RESEARCH　29　S488-S488　2014/02

ISSN： 0884-0431

eISSN： 1523-4681
身体活動分析システムによる都市規模毎の身体活動および行動内容の比較

難波秀行, 石田美香, 高瀬秀人, 山田陽介, 木村みさか

体力科学　63　(1)　74-74　2014/02/01
Publisher: The Japanese Society of Physical Fitness and Sports Medicine
DOI： 10.7600/jspfsm.63.74 　

ISSN： 0039-906X
地域高齢者を対象とした体力科学的アプローチによる認知症とサルコペニア予防の縦断研究―福岡那珂川研究―認知機能低下者の体力特性と運動介入の効果

池永昌弘, 森村和浩, 古瀬裕次郎, 武田典子, 山田陽介, 三好伸幸, 町田由紀子, 栗山緑, 合馬慎二, 坪井義夫, 山田達夫, 桧垣靖樹, 清永明, 田中宏暁

月刊臨床と研究　91　(1)　130-131　2014/01/20

ISSN： 0021-4965
Simultaneous multiple-subject analysis of respiratory gas exchange in humans

Hirano Masami, Yamada Yosuke, Hibi Masanobu, Katashima Mitsuhiro, Higaki Yasuki, Kiyonaga Akira, Tanaka Hiroaki

JPFSM　3　(2)　269-279　2014
Publisher: The Japanese Society of Physical Fitness and Sports Medicine
DOI： 10.7600/jpfsm.3.269 　

ISSN： 2186-8131

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Respiratory gas collection and analysis with indirect calorimetry allows assessment of energy and substrate use during rest and exercise and aerobic capacity. We have developed a novel system for simultaneous multiple-subject measurement of respiratory gas exchange during rest and exercise for up to five subjects, and validated the system with a series of experiments. Thirteen healthy young men (mean age 22 ± 2 years, height 172 ± 6 cm, weight 67.1 ± 11.6 kg) participated in this study. Memory problems of the mass spectrometer, which are caused by switching analyzed gases of different compositions between channels, was sufficiently eliminated with a washout of 2 s (seconds) with errors of less than 0.3% for O₂ and less than 0.4% for CO₂. The high-response mass spectrometer and specially designed mixing chamber enabled correct estimation of metabolic measurements, even for gas concentration data from a non-continuous flow of any given 1s of every 10-s interval (spot-sampling method). Diet-induced thermogenesis (DIT) and oxygen consumption (VO₂) during maximal incremental exercise were not significantly different between the novel and Douglas bag methods (P = 0.61 and P = 0.56, respectively). The limit of agreement of DIT and VO₂ during maximal incremental exercise between the two methods were 2.8 ± 43.6% and 0.9 ± 4.8%, respectively. We concluded that the newly developed system has reasonable validity over a wide range.
身体活動分析システムによる都市規模毎の身体活動および行動内容の比較

難波秀行, 石田美香, 高瀬秀人, 山田陽介, 木村みさか

体力科学　63　(1)　74-74　2014
Publisher: 一般社団法人日本体力医学会
DOI： 10.7600/jspfsm.63.74 　

ISSN： 0039-906X
2P1-18 Development of method to evaluate the performance of the baseball player using quantity of individual part of estimated muscle mass by the Bioelectrical Impedance Analysis

YAMADA Katsuma, OOGIRI Masaru, NARITA Chieko, MATSUI Tomoyuki, YAMADA Yosuke, MIURA Yuichiro, MORIHARA Toru, KIDA Noriyuki, HAMADA Hiroyuki

The Japanese Journal of Ergonomics　50　(0)　S402-S403　2014
Publisher: Japan Ergonomics Society
DOI： 10.5100/jje.50.s402 　

ISSN： 0549-4974

eISSN： 1884-2844
地域在住自立女性高齢者の閉じこもりリスクと体力

山縣恵美, 山田陽介, 桝本妙子, 杉原百合子, 小松光代, 木村みさか, 岡山寧子

日本看護科学学会学術集会講演集　33rd　535　2013/12
地域自立高齢者における外出行動と歩行能力(亀岡スタディより)

木村みさか, 三宅基子, 山田陽介, 渡邊裕也, 吉田司, 横山慶一

体力科学　62　(6)　573　2013/12/01

DOI： 10.7600/jspfsm.62.573 　

ISSN： 0039-906X
運動器不安定症リスクを有する高齢者の身体特性及び認知機能について

古瀬裕次郎, 池永昌弘, 森村和浩, 山田陽介, 武田典子, 清永明, 田中宏暁, 桧垣靖樹

体力科学　62　(6)　608　2013/12/01

DOI： 10.7600/jspfsm.62.608 　

ISSN： 0039-906X
こどもの肥満は身体活動量,特に徒歩通学時間と関係がある―都市部と農村部の小学校6年生における比較―

糸井亜弥, 山田陽介, 木村みさか

体力科学　62　(6)　508　2013/12/01

DOI： 10.7600/jspfsm.62.508 　

ISSN： 0039-906X
長期的地域コホート研究(亀岡スタディ)の研究計画と参加者特性

三宅基子, 木村みさか, 渡邊裕也, 吉田司, 横山慶一, 山田陽介

体力科学　62　(6)　573　2013/12/01

DOI： 10.7600/jspfsm.62.573 　

ISSN： 0039-906X
運動介入による高齢者の歩行リズムおよび体力の変化

横山慶一, 山田陽介, 渡邊裕也, 吉田司, 三宅基子, 木村みさか

体力科学　62　(6)　560　2013/12/01

DOI： 10.7600/jspfsm.62.560 　

ISSN： 0039-906X
地域の介護予防現場で運用可能なサルコペニア予防法の確立

渡邊裕也, 山田陽介, 吉田司, 横山慶一, 三宅基子, 木村みさか

体力科学　62　(6)　586　2013/12/01

DOI： 10.7600/jspfsm.62.586 　

ISSN： 0039-906X
亀岡スタディベースライン調査の特性(年齢・性による特性)

木村みさか, 桝本妙子, 三宅基子, 山田陽介, 山縣恵美, 岡山寧子

日本公衆衛生学会総会抄録集　72nd　417　2013/10/15

ISSN： 1347-8060
地域在住自立男性高齢者の閉じこもりリスクと体力

山縣恵美, 三宅基子, 山田陽介, 桝本妙子, 杉原百合子, 小松光代, 木村みさか, 岡山寧子

日本公衆衛生学会総会抄録集　72nd　408　2013/10/15

ISSN： 1347-8060
亀岡スタディベースライン調査の特性(地域特性)

岡山寧子, 三宅基子, 山田陽介, 山縣恵美, 桝本妙子, 木村みさか

日本公衆衛生学会総会抄録集　72nd　417　2013/10/15

ISSN： 1347-8060
地域在住自立高齢者の抑うつに関連する要因の分析

桝本妙子, 山田陽介, 三宅基子, 小松光代, 山縣恵美, 岡山寧子, 藤原佳典, 木村みさか

日本公衆衛生学会総会抄録集　72nd　420　2013/10/15

ISSN： 1347-8060
高齢者の外傷・介護予防推進・検証の地域コホート研究:亀岡スタディの研究計画概要

三宅基子, 木村みさか, 山田陽介, 山縣恵美, 桝本妙子, 岡山寧子

日本公衆衛生学会総会抄録集　72nd　417　2013/10/15

ISSN： 1347-8060
高齢者の身体能力と安静時心電図補正QT間隔との関係

道下竜馬, 深江知佳, 三原里佳子, 池永昌弘, 森村和浩, 武田典子, 山田陽介, 檜垣靖樹, 田中宏暁, 清永明

日本臨床スポーツ医学会誌　21　(4)　S173　2013/10/01

ISSN： 1346-4159
投手に対する新しい下肢・体幹機能評価の試み

松井知之, 森原徹, 瀬尾和弥, 平本真知子, 東善一, 来田宣幸, 山田陽介, 三浦雄一郎, 吉田司, 池田巧, 北條達也, 堀井基行, 久保俊一

日本臨床スポーツ医学会誌　21　(4)　S212　2013/10/01

ISSN： 1346-4159
女子プロ野球選手における関節可動域の類型化

来田宣幸, 東善一, 松井知之, 瀬尾和弥, 平本真知子, 山田陽介, 森原徹

日本臨床スポーツ医学会誌　21　(4)　S192　2013/10/01

ISSN： 1346-4159
女子プロ野球選手の膝関節筋力の評価基準の作成

吉田司, 山田陽介, 渡邊裕也, 松井知之, 平本真知子, 江藤寿明, 森原徹, 来田宣幸

日本臨床スポーツ医学会誌　21　(4)　S192　2013/10/01

ISSN： 1346-4159
女子プロ野球選手の可動域特性―男子大学生との比較―

平本真知子, 森原徹, 松井知之, 東善一, 瀬尾和弥, 江藤寿明, 吉田司, 祐成毅, 山田陽介, 来田宣幸, 池田巧, 堀井基行, 久保俊一

日本臨床スポーツ医学会誌　21　(4)　S229　2013/10/01

ISSN： 1346-4159
女子プロ野球選手の身体的特性と競技成績の関連性

渡邊裕也, 山田陽介, 吉田司, 瀬尾和弥, 東善一, 島津昭人, 森原徹, 来田宣幸

日本臨床スポーツ医学会誌　21　(4)　S230　2013/10/01

ISSN： 1346-4159
肘関節後方障害投手における投球動作解析

瀬尾和弥, 森原徹, 松井知之, 東善一, 平本真知子, 福島秀晃, 渡邊裕也, 山田陽介, 来田宣幸, 北條達也, 池田巧, 堀井基行, 久保俊一

日本臨床スポーツ医学会誌　21　(4)　S146　2013/10/01

ISSN： 1346-4159
女子プロ野球投手の投球動作時における非投球側股関節内旋,胸腰部回旋,投球側肩関節2nd外旋角度―男子大学生投手との比較―

東善一, 森原徹, 松井知之, 瀬尾和弥, 平本真知子, 島津昭人, 渡邊裕也, 山田陽介, 来田宣幸, 北條達也, 池田功, 堀井基行, 久保俊一

日本臨床スポーツ医学会誌　21　(4)　S230　2013/10/01

ISSN： 1346-4159
中高齢女性における立位姿勢アライメントと背部筋の筋厚および筋内脂肪との関連

正木光裕, 池添冬芽, 福元喜啓, 塚越累, 南征吾, 山田陽介, 木村みさか, 市橋則明

日本理学療法学術大会(Web)　40　(大会特別号3)　O-196　2013/05
Publisher: (公社)日本理学療法士協会
DOI： 10.14900/cjpt.2012.0.48100856.0 　

ISSN： 0289-3770

eISSN： 2189-602X
部位別多周波生体電気インピーダンス分光法を用いた慢性心不全患者の骨格筋評価

棟近麻衣, 白石裕一, 木村みさか, 山田陽介, 山端志保, 福嶋秀記, 堀井基行, 久保俊一

日本心臓リハビリテーション学会学術集会プログラム抄録集(Web)　19th　P-002 (WEB ONLY)　2013
中高齢者の筋力感覚が姿勢制御能力および動作能力に及ぼす影響

福元喜啓, 池添冬芽, 中村雅俊, 塚越累, 山田陽介, 木村みさか, 市橋則明

日本理学療法学術大会(Web)　48th　(大会特別号3)　A-P-26(J-STAGE)-126　2013
Publisher: (公社)日本理学療法士協会
DOI： 10.14900/cjpt.2012.0.48100210.0 　

ISSN： 0289-3770

eISSN： 2189-602X
11教-28-口-10 大学体育に求められる要素 : 授業アンケート結果による考察(11 体育科教育学,一般研究発表抄録)

藤林真美, 山田陽介, 内部昭彦, 横山喬之, 近藤潤, 河瀬泰治

日本体育学会大会予稿集　64　(0)　349-349　2013
Publisher: 一般社団法人日本体育学会
DOI： 10.20693/jspehss.64.349_2 　
中高齢者の筋力感覚が姿勢制御能力および動作能力に及ぼす影響

福元喜啓, 池添冬芽, 中村雅俊, 塚越累, 山田陽介, 木村みさか, 市橋則明

理学療法学Supplement　2012　(0)　48100210-48100210　2013
Publisher: 公益社団法人日本理学療法士協会

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【はじめに，目的】一定の発揮筋力値を正確に再現する能力は筋力感覚（Force sense, 以下FS）と呼ばれ，関節安定性に寄与する固有感覚のひとつとして近年，注目されてきている（Docherty et al, 2004）。先行研究では，FSは筋疲労や関節不安定性により低下することが報告されている（Vuillerme and Boisgonitier 2008, Docherty et al.2006）。良好なFSによる関節安定性は運動中の身体安定性に寄与し，姿勢制御能力や動作能力にも好影響を及ぼしていると推察されるが，これまでFS と姿勢制御能力・動作能力との関連を調べた報告は見当たらない。本研究の目的は，中高齢者のFSを評価し，加齢変化および姿勢制御能力・動作能力との関連性を明らかにすることである。【方法】対象は，地域在住の健常な中高齢女性42 名（平均年齢72.2 ± 7.7 歳）とした。Strain gauge system（DKH社製）を使用し，右側の大腿四頭筋の最大筋力とFSを測定した。測定肢位は端坐位とし，下腿遠位部に張力計測用ベルトを巻いて膝関節屈曲90°位の等尺性収縮にて測定を行った。最大筋力は2 回測定し，大きい値（Nm）をデータ解析に使用した。FS の目標値には，最大筋力の10%と30%の値を用いた。FSの練習課題として，ディスプレイ上に筋力目標値と実際の発揮値をリアルタイム表示し，両者を常に一致させるように対象者に指示した。5 秒間の練習を5 回実施した後，測定課題として，ディスプレイを隠した状態で目標値の筋力発揮を再現させた。5 秒間の計測を行い，実測値と目標値との絶対誤差の平均値を算出し，最大筋力値で正規化（%）した。測定は3 回行い，最も小さい値をFSの指標としてデータ解析に使用した。10%と30%のFS測定順序はランダムとした。姿勢制御能力の評価として片脚立位保持時間（OLS；秒），Functional Reach test（FR；cm），動作能力の評価として，3 分間歩行距離（3MWT；m）， Timed Up and Go test（TUG；秒），垂直跳び（VJI；kgm）を実施した。統計学的検定として，最大筋力，FSと年齢，姿勢制御能力，動作能力との関連を，Spearman順位相関分析を用いて調べた。統計の有意水準は5%未満とした。【倫理的配慮，説明と同意】本研究は，測定機関の倫理委員会の承認を得て行われた。すべての対象者に研究内容に関する説明を行い，書面にて同意を得てから測定を実施した。【結果】FSは，10%では3.46 ± 2.34%，30%では3.88 ± 3.26%であった。最大筋力は年齢（r=−0.41，p<0.01），TUG（r=−0.39，p<0.05），VJI（r=0.43，p<0.01）との間にのみ有意な相関を示した。10%FSは，年齢およびいずれの姿勢制御能力・動作能力とも有意な相関を示さなかった。一方，30%FSはOLS（r=−0.38，p<0.05），3MWT（r=−0.35，p<0.05），TUG（r=0.37，p<0.05）と有意な相関を示したが，年齢とは有意な相関を示さなかった。また，10%FSと30%FSとの間には有意な相関が認められなかった。【考察】本研究の結果より，最大筋力は中高齢期においても加齢変化が進行するが，FSは中高齢期においては加齢変化が生じるわけではないことが示唆された。また最大筋力は動作能力項目とは相関が認められたが姿勢制御能力項目とは相関が認められなかったのに対して，30%FSは動作能力のみならずOLSとも相関が認められた。このことは，中高齢者におけるバランス保持には筋力値の大きさよりも，むしろ動作安定性のための適切な筋力発揮に寄与するFSが重要であることを表していると考えられる。一方，10%FSはどの姿勢制御能力や動作能力とも相関を示さず，また10%FSと30%FSとの間にも相関が認められなかった。このことより，FSであっても目標筋力値の大きさにより異なる特徴を有し，小さい筋力値のFSよりも30%程度のFSのほうが中高齢者の姿勢制御能力や動作能力への影響が大きいことが明らかとなった。【理学療法学研究としての意義】中高齢者の骨格筋機能の評価としてこれまで主に最大筋力が用いられてきたが，本研究は中高齢者の姿勢制御能力や動作能力に影響を与えうる筋機能要因のひとつとしてFSも評価することの重要性を示した。さらに中高齢者の姿勢制御能力・動作能力向上を目指した運動療法の開発のための一助にもなると考えられ，本研究の理学療法学研究としての意義は大きい。
中高齢女性における立位姿勢アライメントと背部筋の筋厚および筋内脂肪との関連

正木光裕, 池添冬芽, 福元喜啓, 塚越累, 南征吾, 山田陽介, 木村みさか, 市橋則明

理学療法学Supplement　2012　(0)　48100856-48100856　2013
Publisher: 公益社団法人日本理学療法士協会

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【はじめに、目的】加齢に伴い立位姿勢アライメントは脊柱後彎や骨盤後傾が増加する。この姿勢アライメントは体幹屈曲筋力とは関連がみられず,体幹伸展筋力と関連があることが報告されている(Kim 2006, Sinaki 1996)。さらに,脊柱・骨盤を中間位に保持した姿勢は,脊柱後彎・骨盤後傾が増加した姿勢よりも腰部多裂筋や腰腸肋筋の筋活動量が高いことが報告されており(O'Sullivan 2006),脊柱・骨盤中間位のアライメントと背部筋との関連性が示唆されている。このように加齢に伴う脊柱後彎・骨盤後傾変化は背部筋の筋機能低下が関連していると考えられている。我々は近年,超音波画像診断装置を使用した研究により,加齢により骨格筋の筋輝度は増加する,すなわち筋内の脂肪組織の増加といった骨格筋の質的変化が生じることや,この質的変化は中高齢者の筋機能に影響を及ぼすことを報告した(Fukumoto 2011,Ikezoe 2012)。しかし,加齢による背部筋の量的・質的変化が姿勢アライメントに影響を及ぼすのかについて詳細に検討した報告はみられない。本研究の目的は,中高齢者における立位姿勢アライメントと背部筋の量的・質的変化との関連性について明らかにすることである。【方法】対象は地域在住の中高齢女性38名(平均年齢72.6±7.8歳)とした。超音波診断装置(GE ヘルスケア社製LOGIQ Book e)を使用し,安静臥位での腰腸肋筋(ES),腰部多裂筋(MF),大腰筋(PM)の横断画像を撮影した。8MHzのリニアプローブを使用し,ゲインなど画像条件は同一設定とした。得られた画像から筋厚,また画像処理ソフト(Image J)を使用し,各筋の筋輝度を算出した。なお,筋輝度は0から255の256段階で表現されるグレースケールで評価され,値が大きいほど高輝度で筋内脂肪などの非収縮組織が増加していることを意味する。筋厚,筋輝度ともに右左の平均値を使用した。姿勢アライメントの測定にはSpinal Mouse(Index社製)を用い,安静立位での胸椎後彎・腰椎前彎・仙骨前傾角度を求めた。統計学的検定として,ピアソンの相関係数を使用し,姿勢アライメント(胸椎後彎・腰椎前彎・仙骨前傾角度)と年齢,筋厚,筋輝度との関係性を検討した。さらに,姿勢アライメントを従属変数,相関分析の結果でp値が0.10未満であった筋厚および筋輝度を独立変数とした重回帰分析を行った。全ての統計の有意水準は5%とした。【倫理的配慮、説明と同意】対象者には研究内容についての説明を行い,書面にて同意を得た。なお,本研究は本学倫理委員会の承認を得て実施した。【結果】安静立位時の姿勢アライメントは,胸椎後彎角度35.7±13.4°,腰椎前彎角度12.6±7.3°,仙骨前傾角度3.2±5.2°であった。胸椎後彎・腰椎前彎・仙骨前傾角度と年齢との間にはいずれも有意な相関がみられなかった。胸椎後彎角度と筋厚,筋輝度との間における単相関係数は,ESの筋厚r=-0.45(p<0.05),筋輝度r=0.08(p=0.61),MFの筋厚r=-0.11(p=0.50),筋輝度r=0.08(p=0.64), PMの筋厚r=-0.32(p=0.05),筋輝度r=0.15(p=0.38)を示した。腰椎前彎角度では,ESの筋厚r=0.14(p=0.39),筋輝度r=0.19(p=0.25),MFの筋厚r=0.18(p=0.27),筋輝度r=-0.07(p=0.70), PMの筋厚r=0.31(p=0.06),筋輝度r=-0.26(p=0.12)を示した。仙骨前傾角度では,ESの筋厚r=0.33(p<0.05),筋輝度r=0.15(p=0.37),MFの筋厚r=0.13(p=0.45),筋輝度r=-0.31(p=0.06), PMの筋厚r=0.48(p<0.05),筋輝度r=-0.38(p<0.05)を示した。また,重回帰分析の結果,胸椎後彎角度に影響を与える有意な因子としてESの筋厚(標準偏回帰係数=-0.39)が抽出され(決定係数=0.22),仙骨前傾角度に影響を与える有意な因子としてPMの筋厚(標準偏回帰係数=0.42),MFの筋輝度(標準偏回帰係数=-0.31)が抽出された(決定係数=0.38)。【考察】中高齢女性の立位姿勢アライメントと背部筋の筋厚・筋輝度との関連性について重回帰分析で検討した結果,ESの筋厚が減少するほど胸椎後彎角度が増加し,PMの筋厚が減少,MFの筋輝度が増加するほど仙骨前傾角度が減少することが示された。これらの結果から,中高齢女性の胸椎後彎の増加には脊柱起立筋の筋量減少,骨盤後傾変化には大腰筋や多裂筋といった深部筋の筋量減少や筋内脂肪増加が関連していることが考えられた。【理学療法学研究としての意義】本研究は,中高齢女性における胸椎,骨盤のアライメントには,背部筋の量的・質的変化が関連していることを明らかにした研究であり,姿勢アライメントの改善に対する運動療法の確立に向けて研究が発展することが期待される。
高齢者における座位開閉ステッピング回数と最大10m歩行速度との関係性

田宮創, 横山慶一, 山田陽介, 吉田司, 吉中康子, 木村みさか

体力科学　61　(6)　746-746　2012/12
Publisher: (一社)日本体力医学会
ISSN： 0039-906X

eISSN： 1881-4751
加齢による四肢・体幹筋の量的・質的変化はどの年齢層から始まるのか? Peer-reviewed

福元喜啓, 池添冬芽, 塚越累, 高木優衣, 山田陽介, 木村みさか, 市橋則明

体力科学　61　(6)　577　2012/12
地域在住高齢者の歩行速度と身体活動量の関係

池永昌弘, 山田陽介, 武田典子, 桧垣靖樹, 田中宏暁, 清永明

体力科学　61　(6)　708　2012/12/01

ISSN： 0039-906X
最大下の持続運動が運動後余剰酸素摂取量に及ぼす影響―ヒューマンカロリーメータを用いた検討―

下山寛之, 畑本陽一, 山田陽介, 吉村英一, 市川麻美子, 桧垣靖樹, 田中宏暁

体力科学　61　(6)　628-628　2012/12/01
Publisher: (一社)日本体力医学会
ISSN： 0039-906X

eISSN： 1881-4751
うつ症状を持つ地域高齢者の身体活動量と体力の特徴

武田典子, 池永昌弘, 三原里佳子, 山田陽介, 檜垣靖樹, 田中宏暁

体力科学　61　(6)　710　2012/12/01

DOI： 10.7600/jspfsm.61.710 　

ISSN： 0039-906X
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西村美帆, 横山慶一, 山田陽介, 吉田司, 石原達朗, 木村みさか

体力科学　61　(6)　662　2012/12/01

ISSN： 0039-906X
骨格筋の筋厚と筋輝度が高齢者の筋力に及ぼす影響

渡邊裕也, 山田陽介, 福元喜啓, 石原達朗, 横山慶一, 吉田司, 木村みさか

体力科学　61　(6)　659　2012/12/01

ISSN： 0039-906X
自立高齢男性における体力と抑うつ傾向との関連

山縣恵美, 山田陽介, 杉原百合子, 小松光代, 木村みさか, 岡山寧子

日本看護科学学会学術集会講演集　32nd　466　2012/11
高齢者におけるArch Indexおよび第一趾側角度からみた足の形態と体力との関連

櫻井寿美, 山田陽介, 木村みさか, 岡山寧子

日本公衆衛生学会総会抄録集　71st　361　2012/10/15

ISSN： 1347-8060
亀岡市在住高齢者における日常的な歩行習慣の有無に関連する要因

三宅基子, 山田陽介, 木村みさか

日本公衆衛生学会総会抄録集　71st　555　2012/10/15

ISSN： 1347-8060
地域高齢者の睡眠と客観的な身体活動量の関連

武田典子, 武田典子, 池永昌弘, 三原里佳子, 松本大葵, 古瀬裕次郎, 山田陽介, 山田陽介, 栗山緑, 桧垣靖樹, 桧垣靖樹, 田中宏暁, 田中宏暁

日本公衆衛生学会総会抄録集　71st　293　2012/10/15

ISSN： 1347-8060
地域在住「元気高齢者」の転倒に関連する要因の横断的分析

桝本妙子, 山田陽介, 山縣恵美, 小松光代, 岡山寧子, 木村みさか

日本公衆衛生学会総会抄録集　71st　355　2012/10/15

ISSN： 1347-8060
地域在住自立高齢者におけるうつ状態と体力(体力測定会に参加する高齢者の場合)

木村みさか, 山縣恵美, 山田陽介, 岡山寧子, 小松光代

日本公衆衛生学会総会抄録集　71st　551　2012/10/15

ISSN： 1347-8060
亀岡スタディにおける高齢者の認知機能と運動能力との関連

藤林真美, 山田陽介, 横山慶一, 吉田司, 木村みさか

スポーツ精神医学　9　A38　2012/08/22

ISSN： 1349-4929
身体知から探る安全を守る看護技術

山田陽介, 山田陽介

日本看護技術学会学術集会講演抄録集　11th　49　2012/08
Effects Of Continuation Of Gymnastics On Fitness Of Middle-age And Elderly Females: Validation By Cross-sectional And Intervention Studies

Yasuko Yosinaka, Yosuke Yamada, Misaka Kimura

JOURNAL OF GENERAL INTERNAL MEDICINE　27　517-517　2012/07

ISSN： 0884-8734

eISSN： 1525-1497
走行中における180°方向転換時の生理的負荷についての検討-方向転換時におけるエネルギー消費量と走行速度の関係-

畑本陽一, 山田陽介, 市川麻美子, 下山寛之, 桧垣靖樹, 清永明, 田中宏暁

体力科学　61　(6)　2012

ISSN： 0039-906X
中高齢女性の尿失禁と静的立位アライメントの関連について

森奈津子, 池添冬芽, 福元喜啓, 武野陽平, 渋田沙央理, 森周平, 高木優衣, 山田陽介, 木村みさか, 岩田学, 市橋則明

理学療法学　39　ROMBUNNO.1127　2012

DOI： 10.14900/cjpt.2011.0.Cb1127.0 　

ISSN： 0289-3770
AGEサポーターの養成と元気アップ体操教室介護予防を目的にした大規模コホート研究のために

吉中康子, 木村みさか, 山田陽介

日本体育学会大会予稿集　63rd　333-333　2012
Publisher: 社団法人日本体育学会
DOI： 10.20693/jspehss.63.333_3 　
陸上競技短距離選手の基礎代謝量と身体組成

小清水孝子, 山田陽介, 市川麻美子, 畑本陽一, 下山寛之, 山崎一彦, 清永明, 桧垣靖樹, 田中宏暁

日本トレーニング科学会大会プログラム・抄録集　25th　100-100　2012
Publisher: 日本トレーニング科学会
14介-24-ポ-21 AGEサポーターの養成と元気アップ体操教室 : 介護予防を目的にした大規模コホート研究のために(介護福祉・健康づくり,ポスター発表,一般研究発表抄録)

吉中康子, 木村みさか, 山田陽介

日本体育学会大会予稿集　63　(0)　333-333　2012
Publisher: 一般社団法人日本体育学会
DOI： 10.20693/jspehss.63.333_3 　
中高齢女性の尿失禁と静的立位アライメントの関連について

森奈津子, 岩田学, 市橋則明, 池添冬芽, 福元喜啓, 武野陽平, 渋田沙央理, 森周平, 高木優衣, 山田陽介, 木村みさか

理学療法学Supplement　2011　(0)　Cb1127-Cb1127　2012
Publisher: 公益社団法人日本理学療法士協会

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【はじめに、目的】尿失禁は、生活範囲の縮小や経済的負担の増加、精神的ストレス、生活の質の低下などを招き、日常生活へ及ぼす影響が大きい。尿失禁のなかでも腹圧性尿失禁(stress urinary incontinence; SUI)は骨盤底に構造的な弱点のある女性に特異的に多いタイプの尿失禁であり、分娩・加齢・肥満による骨盤底筋の機能低下に伴いSUI発生のリスクが高まることが知られている。SUI発生リスクと関連する骨盤底筋の筋活動は、体幹や骨盤のアライメントを実験的に変化させることで筋活動も変化することが報告されている。このことから、SUI発生は姿勢アライメントとも関連している可能性があるが、実際に尿失禁のある女性の姿勢アライメントとSUIの関連を詳細に調べた研究は見当たらない。そこで本研究は、中高齢女性のSUIと静的立位姿勢における身体アライメントの関連を明らかにすることを目的とした。【方法】地域在住の60～70歳代の健常女性109名（平均年齢69.9±4.7歳）を対象とした。尿失禁の頻度や量、誘因に関する自覚的評価表（ICIQ-SF）により、最近1年間の尿失禁を調査した。ICIQ-SFにより、尿失禁の誘因として「くしゃみやせきをしたとき」や「運動時」に尿失禁があると回答した者をSUIあり群と定義し、尿失禁がないと回答した者をSUIなし群とした。身体アライメントとして、静止立位における矢状面のアライメントを測定した。スパイナルマウス（INDEX社製）を用い、胸椎後弯角度と腰椎前弯角度を測定した。測定は2回行い、平均値を求めた。また、静止立位を右側方からデジタルカメラで撮影し、耳垂・肩峰・上前腸骨棘・上後腸骨棘・大転子・膝関節裂隙・外果の7箇所に添付したマーカーにより、骨盤前傾角度、股関節屈曲角度、膝関節屈曲角度、足関節背屈角度、外果に対する頭部（耳垂）の前後位置、外果に対する骨盤（上前腸骨棘と上後腸骨棘の中点）の前後位置を測定した。さらに重心動揺計を用いて足圧中心の前後位置を測定し、足長に対する踵からの位置（％）を算出した。統計学的検定として目的変数をSUIの有無、説明変数を年齢と身体アライメントの各測定項目とした多重ロジスティック回帰分析を行い、SUIと関連する因子を検討した。有意水準は5％未満とした。【倫理的配慮、説明と同意】被験者には研究内容について口頭にて十分な説明を行い、書面にて同意を得た。【結果】 SUIなし群は51名、SUIあり群は41名であり、その他の17名はSUI以外の尿失禁がみられた。SUIあり・なしの2群間の年齢、身長、体重、BMIには有意差はみられなかった。SUIなし群およびSUIあり群それぞれの身体アライメントは胸椎後弯角度が34.3±9.9°、37.4±10.7°、腰椎前弯角度が20.7±7.1°、18.0±10.0°、骨盤前傾角度が6.3±6.8°、4.5±8.6°、股関節屈曲角度が6.7±15.1°、2.1±9.2°、膝関節屈曲角度が6.3±15.2°、3.5±5.7°、足関節背屈角度が5.9±3.6°、5.9±3.7°、外果に対する頭部の前方位置が2.9±2.2cm、3.1±3.3cm、外果に対する骨盤の前方位置が2.7±2.2cm、2.8±2.3cm、足圧中心の前後位置が42.6±5.1％、43.3±8.4％であった。多重ロジスティック回帰分析の結果、身体アライメント測定項目のなかで胸椎後弯角度と腰椎前弯角度がSUIに影響を及ぼす有意な因子として抽出され、オッズ比は胸椎後弯角度1.06（95％信頼区間：1.00～1.12）、腰椎前弯角度0.92（95％信頼区間：0.86～0.99）であった。【考察】本研究の結果、胸椎後弯角度および腰椎前弯角度のみがSUIと関連する因子として抽出された。ただし、そのオッズ比は1.06、0.92であることから、SUI発生に及ぼす影響力としては大きくないと思われる。先行研究によりSUIのある者において、胸腰椎後弯が増強した「Slump姿勢」では、直立姿勢に比べて尿失禁に関与する骨盤底筋の筋活動が低下すると報告されている。骨盤底筋は腹腔内圧の上昇にあわせた活動をしており、胸椎後弯が増強したり腰椎前弯が減少したりすると腹腔内圧が低下することによって骨盤底筋の活動は低下すると考えられる。これらのことから、胸椎後弯角度および腰椎前弯角度はSUI発生リスクと関連性がみられたと考えられた。【理学療法学研究としての意義】今回、中高齢女性の尿失禁の発生と姿勢アライメントとの関連が明らかとなった。本研究結果は尿失禁の予防・改善を目指した理学療法を行ううえで考慮すべき重要な知見であると考える。
身体活動量とHbA1c高値リスクに関する研究

安方惇, 徳田拓巳, 三好伸幸, 山田陽介, 田口尚人, 原めぐみ, 中村和代, 南里妃名子, 今泉猛, 坂本龍彦, 新地浩一, 田中恵太郎, 清永明, 田中宏暁, 桧垣靖樹

体力科学　60　(6)　813-813　2011/12
Publisher: (一社)日本体力医学会
ISSN： 0039-906X

eISSN： 1881-4751
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下山寛之, 吉村英一, 山田陽介, 首藤千輝, 清永明, 檜垣靖樹, 田中宏暁

体力科学　60　(6)　682　2011/12/01

ISSN： 0039-906X
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三好伸幸, 森村和浩, 山田陽介, 安方惇, 飛奈卓郎, 清永明, 田中宏暁

体力科学　60　(6)　730　2011/12/01

ISSN： 0039-906X
地域高齢者における起立性低血圧とバランス能力の関係

畠中大誠, 山田陽介, 池永昌弘, 松本大葵, 木村みさか, 田中宏暁

体力科学　60　(6)　806　2011/12/01

ISSN： 0039-906X
中敷に約200g加重した靴の生活介入が高齢者の下肢筋量および歩容に及ぼす影響

池永昌弘, 山田陽介, 吉田智恵, 三原里佳子, 藤井慶輔, 平野雅巳, 森村和浩, 進藤宗洋, 清永明

体力科学　60　(6)　827　2011/12/01

ISSN： 0039-906X
睡眠時間とHbA1c高値リスクに関する研究

徳田拓巳, 安方惇, 三好伸幸, 山田陽介, 田口尚人, 原めぐみ, 新地浩一, 中村和代, 南里妃名子, 今泉猛, 坂本龍彦, 田中恵太郎, 清永明, 田中宏暁, 桧垣靖樹

体力科学　60　(6)　813-813　2011/12
Publisher: (一社)日本体力医学会
ISSN： 0039-906X

eISSN： 1881-4751
Trail Making Test(TMT)による遂行機能評価と歩行機能および体力関連項目との関係

吉田智恵, 山田陽介, 池永昌弘, 木村みさか, 三原里佳子, 田中宏暁, 檜垣靖樹, 清永明

体力科学　60　(6)　733　2011/12/01

ISSN： 0039-906X
姿勢制御における筋の同時活動―若年者と高齢者の比較―

坪山直生, 永井宏達, 山田実, 上村一貴, 山田陽介, 市橋則明

Osteoporosis Japan　19　316　2011/11/03

ISSN： 0919-6307
生活機能向上をめざした訪問介護による介護予防の支援と検証

木村みさか, 山田陽介, 山縣恵美, 岡山寧子, 村井千賀, 田中甲子

日本公衆衛生学会総会抄録集　70th　303　2011/10/15

ISSN： 1347-8060
要支援高齢者における家事遂行能力尺度の妥当性検証(体力・筋量・活動量との関連)

山田陽介, 木村みさか, 村井千賀, 田中甲子

日本公衆衛生学会総会抄録集　70th　303　2011/10/15

ISSN： 1347-8060
08測-25-ポ-29 走っても歩いてもよいシャトルテスト「新SST」 : 加齢変化と他の体力要素との関連からみた妥当性の検討(08.測定評価,一般研究発表抄録)

池島明子, 木村みさか, 金子公宥, 山田陽介, 田中宏暁

日本体育学会大会予稿集　62　(62)　202-202　2011/09/25
Publisher: 社団法人日本体育学会
DOI： 10.20693/jspehss.62.202_2 　
10保-25-口-09 高齢者の体力年齢の推定式の作成とその妥当性の検討(10.保健,一般研究発表抄録)

中村榮太郎, 山田陽介, 木村みさか

日本体育学会大会予稿集　62　(62)　247-247　2011/09/25
Publisher: 社団法人日本体育学会
DOI： 10.20693/jspehss.62.247_3 　
14介-26-ポ-24 縦断的データに基づく高齢者の体力変化と易転倒性(14.介護福祉・健康づくり,一般研究発表抄録)

木村みさか, 山田陽介, 中村榮太郎

日本体育学会大会予稿集　62　(62)　312-312　2011/09/25
Publisher: 社団法人日本体育学会
DOI： 10.20693/jspehss.62.312_3 　
14介-26-ポ-26 体操継続と認知機能改善についての基礎研究(14.介護福祉・健康づくり,一般研究発表抄録)

吉中康子, 山田陽介, 木村みさか

日本体育学会大会予稿集　62　(62)　313-313　2011/09/25
Publisher: 社団法人日本体育学会
DOI： 10.20693/jspehss.62.313_2 　
短期間の過食による体重増加は水分か脂肪か

軸丸優, 山田陽介, 平田明子, 吉村英一, 下山寛之, 清永明, 田中宏暁, 桧垣靖樹

肥満研究　17　(Supplement)　145　2011/09/01

ISSN： 1343-229X
女子アスリートにおける心身の関連

藤林真美, 山田陽介, 安藤創一, 中井誠一, 木村みさか, 森谷敏夫

スポーツ精神医学　8　A22　2011/08/15

ISSN： 1349-4929
Effects of skeletal muscle echo intensity and thickness on muscle strength and physical function in age over 50. Peer-reviewed

Fukumoto Yoshihiro, Ikezoe Tome, Yamada Yosuke, Kimura Misaka, Tsukagoshi Rui, Nakamura Masatoshi, Mori Natsuko, Ichihashi Noriaki

16th WCPT International Congress, Amsterdam, Netherland.　2011/06/21
要介護高齢者における脱水予防の評価方法の検討―体内水分量と皮膚水分との関連から―

岡山寧子, 仲前美由紀, 小松光代, 杉原百合子, 山縣恵美, 木村みさか, 山田陽介

老年社会科学　33　(2)　286　2011/06/10

ISSN： 0388-2446
5年から9年間観察した高齢者における体力変化量と転倒との関連―毎年継続実施している体力測定会への参加者の場合―

水野順子, 岡山寧子, 山田陽介, 木村みさか

老年社会科学　33　(2)　284　2011/06/10

ISSN： 0388-2446
訪問介護による介護予防(生活機能向上に着目して)―ホームヘルプ利用者における介入支援と介入効果の検証―

木村みさか, 山田陽介, 吉中康子, 村井千賀, 田中甲子

老年社会科学　33　(2)　287　2011/06/10

ISSN： 0388-2446
虚弱高齢者に対する介護予防の5年間の取組み―軽費老人ホームでの自主的な運動習慣獲得システムの評価―

吉中康子, 山田陽介, 木村みさか

老年社会科学　33　(2)　315　2011/06/10

ISSN： 0388-2446
The Activity Level Of Children Has Decreased Considerably During The Past 10 Years: Comparison In The Same Elementary School

Misaka Kimura, Aya Itoi, Yosuke Yamada, Satoshi Nakae

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE　43　(5)　726-726　2011/05

DOI： 10.1249/01.MSS.0000402017.00363.10 　

ISSN： 0195-9131

eISSN： 1530-0315
Effects Of Continuation Of Gymnastics On Fitness Of Middle-age And Elderly Females: Validation By Cross-sectional And Intervention Studies

Yasuko Yosinaka, Yosuke Yamada, Misaka Kimura

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE　43　(5)　517-517　2011/05

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The Sarcopenia Determined by Cellular Level Approach is Related to Daily Physical Activity in the Elderly

Yosuke Yamada, Emi Yamagata, Yasuko Okayama, Hiroaki Tanaka, Misaka Kimura

INTERNATIONAL JOURNAL OF OBESITY　35　S55-S55　2011/05

ISSN： 0307-0565
姿勢制御エクササイズが高齢者における筋の同時活動に及ぼす影響―無作為化比較対象試験―

永井宏達, 山田実, 田中武一, 上村一貴, 森周平, 山田陽介, 青山朋樹, 市橋則明, 坪山直生

理学療法学　38　(2)　ROMBUNNO.OS3-063-89　2011
Publisher: (公社)日本理学療法士協会
DOI： 10.14900/cjpt.2010.0.EeOS3063.0 　

ISSN： 0289-3770

eISSN： 2189-602X
アンケートからわかる多職種協働での在宅化学療法の課題

清水公一, 岡元るみ子, 高橋慶一, 山田陽介, 横井和枝, 横井和枝, 林章敏

日本臨床腫瘍学会学術集会プログラム・抄録集　9th　300　2011
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永井宏達, 山田実, 田中武一, 上村一貴, 森周平, 山田陽介, 青山朋樹, 市橋則明, 坪山直生

理学療法学Supplement　2010　(0)　EeOS3063-EeOS3063　2011
Publisher: 公益社団法人日本理学療法士協会
ISSN： 0289-3770

eISSN： 2189-602X
中高齢女性のバランス能力を維持するために最低限必要な下肢筋力水準値

正木光裕, 池添冬芽, 福元喜啓, 中村雅俊, 高木優衣, 山田陽介, 木村みさか, 市橋則明

近畿理学療法学術大会　2011　(0)　85-85　2011
Publisher: 社団法人日本理学療法士協会近畿ブロック

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【目的】 中高齢者の加齢に伴う下肢筋力低下はバランス能力障害に影響することが知られている。しかし、下肢筋力がどの程度低下すると、転倒につながるバランス能力障害が生じるかという下肢筋力の水準値は明らかではない。またこれまで下肢筋力の加齢変化や、下肢筋力とバランス能力との関連を調べた研究では膝関節伸展筋力に関する報告が多いが、股関節外転筋力について検討した報告はほとんどない。 本研究の目的は、中高齢女性の下肢筋力(膝伸展筋力および股外転筋力)の加齢変化の違いを調べること、および下肢筋力とバランス能力(Functional reach(FR)および片脚立位保持時間)との関連を分析し、良好なバランス能力を維持するために最低限必要な下肢筋力の水準値を明らかにすることである。 【方法】 対象は本学学生19名(平均年齢19.9±0.7歳,以下若年群)および地域在住で日常生活が自立している中高齢女性188名(平均年齢72.1±6.8歳)とした。中高齢女性は年齢により中年群27名(61.6±2.4歳)、前期高齢群90名(69.7±2.6歳)、後期高齢群71名(79.1±3.7歳)に群分けした。股外転筋力の測定にはHand-held Dynamometer(アニマ社製μ-Tas F-1)、膝伸展筋力の測定にはStrain-gauge Systemを使用した。股外転筋力は背臥位で股関節内外転中間位、膝伸展筋力は端座位で膝関節90°屈曲位にて右側の最大等尺性筋力(N)を測定した。筋力測定は2回行い最高値をデータに用いた。筋力値はアーム長を乗じ体重で除したトルク体重比(Nm/kg)で表した。さらに若年群の平均筋力値を基準値(100%)として、それぞれ中年群・前期高齢群・後期高齢群における筋力の若年比(%）を算出した。また中高齢女性のみを対象に、バランス能力としてFRおよび開眼片脚立位保持時間の測定を行った。 統計学的検定として、まず加齢による下肢筋力の変化を分析するために、一元配置分散分析およびScheff&eacute;法を用いて年代層間の筋力値の比較、Wilcoxonの符号付順位検定を用いて筋間の筋力若年比の比較を行った。また、中高齢女性のバランス能力に必要な下肢筋力水準値を求めるために、FRおよび開眼片脚立位保持時間それぞれについて、先行研究による転倒リスクのカットオフ値(FRは26cm、開眼片脚立位保持時間は5秒)により、対象者をバランス良好群とバランス不良群に分類した。バランス良好群とバランス不良群における膝伸展筋力および股外転筋力値をMann-Whitney検定にて比較し、2群間に有意な差があった項目については、判別分析を用いて2群を判別する判別値および判別的中率を求めた。有意水準は5%未満とした。 【説明と同意】 全ての対象者に研究内容についての説明を行い、同意書に署名を得た。 【結果】 加齢による下肢筋力の変化について、股外転筋力のトルク体重比では中年群・前期高齢群・後期高齢群が若年群よりも有意に低かったが、その他の群間に有意な差はみられなかった。膝伸展筋力のトルク体重比では中年群・前期高齢群・後期高齢群が若年群よりも有意に低く、さらに後期高齢群が中年群よりも有意に低かった。また、筋力若年比は、中年群（股外転76.7%,膝伸展63.1%）・前期高齢群(股外転72.2%,膝伸展54.1%)・後期高齢群(股外転65.1%,膝伸展48.9%)の全ての年代層において、膝伸展が股外転よりも有意に低かった。 FRにおけるバランス良好群とバランス不良群の筋力値を比較した結果、膝伸展筋力値には有意な差がみられなかったが、股外転筋力値ではバランス良好群よりバランス不良群で有意に低かった。２群間に有意な差があった股外転筋力値についてのみ判別分析を行った結果、2群を判別する判別値は1.28Nm/kg(若年比70.3％)であり、判別的中率は63.4%であった(p<0.01)。 片脚立位保持時間におけるバランス良好群とバランス不良群の下肢筋力値を比較した結果、膝伸展筋力値には有意な差がみられなかったが、股外転筋力値ではバランス良好群よりバランス不良群で有意に低かった。2群間に有意な差があった股外転筋力値についてのみ判別分析を行った結果、2群を判別する判別値は1.29Nm/kg(若年比70.6％)であり、判別的中率は63.2%であった(p<0.05)。 【考察】 本研究により、中高齢女性の加齢による筋力低下は股外転筋力より膝伸展筋力の方が著しいことが明らかになった。しかしバランス能力には膝伸展筋力よりも股外転筋力が影響しており、股外転筋力がトルク体重比で約1.30Nm/kg、若年比で約70％を下回ると、転倒につながるバランス能力障害が生じやすいことが示唆された。 【理学療法研究としての意義】 中高齢女性の転倒を予防するためにはバランス能力を維持することが重要である。本研究の結果、良好なバランス能力を維持するためには、最低限1.30Nm/kg程度の股外転筋力を維持することも重要であると考えられた。
縦断的データにみる高齢者における体力と転倒(毎年継続実施している体力測定会への参加者の場合)

木村みさか, 山田陽介, 岡山寧子

体力科学　59　(6)　671　2010/12/01

ISSN： 0039-906X
血流供給からみた大学男子サッカー選手の前脛骨筋持久力

池永昌弘, 伊古田健夫, 平野雅巳, 森村和浩, 山田陽介, 進藤宗洋, 清永明

体力科学　59　(6)　738　2010/12/01

ISSN： 0039-906X
後ろ向き走歩行の生理応答―前向き走歩行との比較―

畑本陽一, 山田陽介, 山下陽平, 下山寛之, 田中宏暁

体力科学　59　(6)　920　2010/12/01

ISSN： 0039-906X
がん性疼痛の診断と治療の進め方がん性疼痛治療―私はこう説明している―1)

山田陽介

がん患者と対症療法　21　(2)　147-152　2010/10/25

ISSN： 0918-8509
運動中の心筋仕事量と運動強度との関連

山田陽介, 松田拓朗, 飛奈卓郎, 畠中大誠, 畑本陽一, 冨賀裕貴, 坂井秀章, 山岸民治, 田中宏暁

日本臨床生理学会雑誌　40　(5)　83　2010/10/20

ISSN： 0286-7052
運動時の第2心音振幅と中心血圧の関係

土井由紀子, 山田陽介, 松田拓朗, 松本大葵, 飛奈拓朗, 坂井秀章, 山岸民治, 田中宏暁

日本臨床生理学会雑誌　40　(5)　71　2010/10/20

ISSN： 0286-7052
運動中の第一心音振幅は心収縮力を反映する

松田拓朗, 山田陽介, 松本大葵, 飛奈卓郎, 坂井秀章, 山岸民治, 田中宏暁

日本臨床生理学会雑誌　40　(5)　71　2010/10/20

ISSN： 0286-7052
Autonomic Nervous System Activity and Psychological Influence on Female Elite Runner

Fujibayashi Mami, Yamada Yosuke, Ando Soichi, Nakai Seiichi, Kimura Misaka, Moritani Toshio

JOURNAL OF PSYCHOSOMATIC OBSTETRICS AND GYNECOLOGY　31　109-109　2010/10

ISSN： 0167-482X
Fall efficacy is related to muscular coactivation at ankle joint during walking in older people. Peer-reviewed

Tsuboyama T, Nagai K, Yamada M, Uemura K, Yamada Y, Ichihashi N

85e r?union annuelle de la soci?t? fran?aise de chirurgie orthop?dique et traumatologique.　2010/10
03心-2A-K13 女子トップアスリートにおける自律神経活動と心理面との関連(03.体育心理学,一般研究発表抄録)

藤林真美, 山田陽介, 安藤創一, 中井誠一, 木村みさか, 森谷敏夫

日本体育学会大会予稿集　61　(61)　104-104　2010/09/08
Publisher: 社団法人日本体育学会
DOI： 10.20693/jspehss.61.104_1 　
04生-3P-P14 運動時における脳の組織酸素飽和度の変化は認知機能に影響を与えるか?(04.運動生理学,一般研究発表抄録)

安藤創一, 國部雅大, 山田陽介, 木村みさか

日本体育学会大会予稿集　61　(61)　142-142　2010/09/08
Publisher: 社団法人日本体育学会
DOI： 10.20693/jspehss.61.142_1 　
14介-2A-P10 体操(Gymnastics for ALL)の継続と体力に関する研究 : 長期にわたる体操継続効果の検証(14.介護福祉・健康づくり,一般研究発表抄録)

吉中康子, 木村みさか, 山田陽介

日本体育学会大会予稿集　61　(61)　307-307　2010/09/08
Publisher: 社団法人日本体育学会
DOI： 10.20693/jspehss.61.307_1 　
子どもの活動量は最近10年間でかなり減少している(同一小学校6年生における調査結果より)

木村みさか, 糸井亜弥, 山田陽介, 中江悟司

肥満研究　16　(Supplement)　153　2010/09/01

ISSN： 1343-229X
A-028 Convergence of Approximately Nash Transition in Some Incomplete Congestion Games

Yamada Yosuke, Ono Hirotaka, Kijima Shuji, Yamashita Masafumi

情報科学技術フォーラム講演論文集　9　(1)　231-232　2010/08/20
Publisher: Forum on Information Technology
自立・虚弱高齢女性における体内水分量と腋窩皮膚水分の関連

仲前美由紀, 岡山寧子, 木村みさか, 山田陽介

日本看護研究学会雑誌　33　(3)　316　2010/07/21

ISSN： 0285-9262
自立高齢女性における体内水分量と体力との関連

山縣恵美, 小松光代, 木村みさか, 岡山寧子, 山田陽介

日本看護研究学会雑誌　33　(3)　316　2010/07/21

ISSN： 0285-9262
ロコモティブシンドローム一般診療とロコモティブシンドローム 4 介護予防と体力,サルコペニア

木村みさか, 山田陽介

治療学　44　(7)　795-800　2010/07/10

ISSN： 0386-8109
二重標識水法を用いたイヌのエネルギー代謝量の推定

大辻一也, 後藤亜紗美, 櫻井富士朗, 城定沙織, 林ゆかり, 藤田暁世, 伴武, 大川雅之, 梅田智重, 山田陽介

ペット栄養学会誌　13　(Supplement)　25-26　2010/07/10

DOI： 10.11266/jpan.13.Suppl_25 　

ISSN： 1344-3763
高齢者におけるサルコペニアを簡便に正確に評価する方法の検討―部位別生体電気インピーダンス分光法(S‐BIS)による―

山田陽介, 木村みさか

老年社会科学　32　(2)　247　2010/06/10

ISSN： 0388-2446
高齢者における将来の転倒を予測する体力要素の検討―毎年継続実施している体力測定会への参加者の場合―

水野順子, 岡山寧子, 水田千夏, 山田陽介, 木村みさか

老年社会科学　32　(2)　248　2010/06/10

ISSN： 0388-2446
Basketball Players Rotate Their Shoulders During Running While Dribbling

Keisuke Fujii, Yosuke Yamada, Shingo Oda

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE　42　(5)　687-687　2010/05

ISSN： 0195-9131
Decline Of Muscle Quality In The Lower Extremities With Aging And Mobility Disability

Yosuke Yamada, Eitaro Nakamura, Taketoshi Morimoto, Yasuko Okayama, Hiroaki Tanaka, Shingo Oda, Misaka Kimura

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE　42　(5)　405-405　2010/05

ISSN： 0195-9131
こどもの足型に見られる問題と身体活動との関係―都市部小学校6年生児童における調査から―

糸井亜弥, 木村みさか, 走井裕香子, 安藤創一, 櫻井寿美, 山田陽介, 中江悟司, 諏佐準一

日本発育発達学会大会抄録集　8th　95　2010/03/10
幼児における身体活動量と体力・運動能力との関係

青木好子, 木村みさか, 山田陽介, 弘中陽子, 岡本幸治, 石田良恵, 中江悟司

日本発育発達学会大会抄録集　8th　62　2010/03/10
部位別生体電気インピーダンス分光法(S‐BIS)を用いた簡便で正確なサルコペニアの評価法

山田陽介, 田中宏暁, 木村みさか

健康支援　12　(1)　95　2010/02/01

ISSN： 1345-0174
虚弱・要介護者における生活行為向上を支援する運動プログラム(デイサービス利用者での試み)

木村みさか, 山田陽介

健康支援　12　(1)　110　2010/02/01

ISSN： 1345-0174
2-P-16 Evaluation of age-associated changes in the total body water and fitness using SBIA in ADL-independent elderly females : A basic study for the prevention of heat stroke(The Proceedings of the 18th Annual Meetings of Japan Society Exercise and Sports Physiology Jury 31 August 1, (Kagoshima)) :

KIMURA Misaka, YAMADA Yosuke

Advances in exercise and sports physiology　16　(2)　81-81　2010
Publisher: Japan Society of Exercise and Sports Physiology
ISSN： 1340-3141
高齢者における歩行時の筋の同時活動は転倒恐怖感と関連がある

永井宏達, 山田実, 竹岡亨, 田中武一, 上村一貴, 山田陽介, 市橋則明, 坪山直生

理学療法学　37　(Suppl.2)　ROMBUNNO.SH2-004-476　2010
Publisher: (公社)日本理学療法士協会
DOI： 10.14900/cjpt.2009.0.E1Sh2004.0 　

ISSN： 0289-3770

eISSN： 2189-602X
SBIA法を用いた自立高齢女性における体内水分量の加齢変化と体力(暑熱障害予防のための基礎的研究)

木村みさか, 山田陽介

日本運動生理学会大会プログラム・抄録集　18th　79　2010
体操(Gymnastics for ALL)の継続と体力に関する研究―長期にわたる体操継続効果の検証―

吉中康子, 木村みさか, 山田陽介

日本体育学会大会予稿集　61st　307　2010
運動時における脳の組織酸素飽和度の変化は認知機能に影響を与えるか?

安藤創一, 國部雅大, 山田陽介, 木村みさか

日本体育学会大会予稿集　61st　142-142　2010
Publisher: 社団法人日本体育学会
DOI： 10.20693/jspehss.61.142_1 　
転倒リスク評価のための複数課題条件下での移動能力質問紙表の開発

山田実, 島田裕之, 竹上未紗, 山田陽介, 前田裕子, 永井宏達, 田中武一, 竹岡亨, 上村一樹, 市橋則明

理学療法学　37　ROMBUNNO.SH2-028　2010

DOI： 10.14900/cjpt.2009.0.A1Sh2028.0 　

ISSN： 0289-3770
減量を目的とした12週間の食事制限と運動トレーニングの併用が除脂肪体重に及ぼす影響

渡部貴和, 吉村英一, 平田明子, 熊原秀晃, 綾部誠也, 飛奈卓郎, 山田陽介, 清永明, 桧垣靖樹, 田中宏暁

日本肥満症治療学会学術集会プログラム・抄録集　3rd　101　2010
二重標識水法を用いたイヌのエネルギー代謝量の推定

大辻一也, 山田陽介, 後藤亜紗美, 櫻井富士朗, 城定沙織, 林ゆかり, 藤田暁世, 伴武, 大川雅之, 梅田智重

ペット栄養学会誌　13　(0)　Suppl_25-Suppl_26　2010
Publisher: 日本ペット栄養学会
ISSN： 1344-3763

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イヌの飼育環境の変化に伴って、エネルギー代謝量も変化していることが予想される。そこで、二重標識水法を用いて、一般家庭で飼育されている体重8.6kgのパグと8.1kgのフレンチブルドッグ 2 頭を用いて、普段の生活におけるエネルギー代謝量を測定した。その結果、前者は458kcal/日、後者は462kcal/日と推定された。
転倒リスク評価のための複数課題条件下での移動能力質問紙表の開発

山田実, 市橋則明, 島田裕之, 竹上未紗, 山田陽介, 前田裕子, 永井宏達, 田中武一, 竹岡亨, 上村一樹

理学療法学Supplement　2009　(0)　A1Sh2028-A1Sh2028　2010
Publisher: 公益社団法人日本理学療法士協会

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【目的】 人が日常生活において活動する際は、「荷物を持って移動する」、「電話の着信音を気にしながら移動する」等、二つ以上の課題を同時に処理することが求められる。近年、高齢者における転倒予防の分野では、この複数課題条件下での課題遂行能力の低下が転倒リスクを高める要因となることが報告されている。とくに、運動機能が保持されているにも関わらず転倒する高齢者の転倒リスクを把握するためには、単純な課題より複数課題を課すことで転倒の潜在的な危険性を抽出できる可能性がある。しかし、在宅等で転倒リスク評価を行う際には、測定場所の確保が困難、カットオフ値が不明確等の理由により、このような転倒リスク評価が行いにくいのも事実である。 そこで、本研究ではtimed up and go test（TUG）が13.5秒以下（転倒のカットオフ値以下の値）であり、運動機能が保持されている高齢者を対象に、潜在的な転倒リスクを判断するための質問紙の開発を目的とした。質問紙は、複数課題条件下での移動能力を調査する内容とし、誰もがどこでも簡便に測定することが可能な質問紙表の作成を目指した。 【方法】 対象者は地域在住高齢者161名（年齢75±8歳、身長157±9cm、体重56±9kg、女性の割合79.3%）であった。TUGが13.5秒以上の者は除外した。 質問紙表の作成は、文献レビューおよび転倒状況の予備調査によって、転倒の発生は、「歩行」、「立ちしゃがみ」、「方向転換」で多発し、転倒の発生機序としては、「つまずき」や「滑り」が大半を占めるということが明確となった。また複数課題的情報としては、「何か持っていた」、「何か探していた」、「急いでいた」などの理由を得た。これらの結果をふまえ、単一あるいは複数課題条件で表現した動作の可否を問う質問文章を作成した。文章は、理学療法士、看護師、保健師、および非医療従事者で構成されたメンバーで入念に確認し、高齢者の方でも理解しやすい表現とした。なお、作成された文章は20名の高齢者を対象に、複数回に渡って予備調査を行い、修正を重ね、繰り返し測定しても同じ結果になるまで文章の修正を行った。なお、質問数は最初に50個あった候補から、類似した表現の質問を削除して14項目まで絞ってから分析した。回答方法は、「はい」か「いいえ」の二者択一方式とした。 統計解析は、14項目の調査結果からバリマックス回転法による因子分析を実施した。因子数の決定は主因子分析とし、各因子における因子負荷量が最大であった項目を最終的な調査項目として採用した。各調査項目に1点の配点を与え（動作困難な場合を1点）、その合計点によって転倒リスクの判定が可能か検討するため、従属変数に過去1年間の転倒歴を投入した判別分析を行い、ROC曲線によってカットオフ値を求めた。 【説明と同意】 参加者には紙面および口頭にて研究の目的および方法などに関して十分な説明を行い、署名にて同意を得た。 【結果】 本研究の対象となった161名の高齢者において、過去1年間に転倒経験を有していた者は52名（32.3%）であった。因子分析の結果、因子数が4因子のときに最適解が得られ、質問項目は4項目と決定した。選ばれた4項目は、（1）何も持たずに椅子から立ち上がれますか、（2）何も入っていない空のコップを持っていて、真後ろへ方向転換できますか、（3）水やお茶などが入ったコップを持っていてもこぼさずに歩くことができますか、（4）トイレに行くときや電話が鳴っているときなど、急いでいるときには敷居やカーペットなどの段差につまずくことがありますか、であった。判別分析の結果では、正準相関係数は0.414、正判別率は71.3%であり、ROC曲線より求めたカットオフ値は1点（感度63.5%、特異度75.0%）となった。 【考察】 本質問紙は、従来の運動機能のスクリーニングでは転倒リスクを判断することが困難な高齢者用に作成した。因子分析によって選ばれた質問項目は、立ち上がり、方向転換、歩行、つまずきの要素がそれぞれ含まれ、転倒リスクを比較的広範囲に捉えているものと考えられた。また、立ち上がりを除くそれぞれの質問内容が、複数課題条件となっていることで、潜在的な転倒リスクを高感度で判別できたため、4項目の簡単な質問だけで、過去1年間の転倒の識別が71.3%可能であったものと考えられた。 【理学療法学研究としての意義】 本研究で開発した質問紙は、簡便な4項目の質問で構成され、簡便に利用できるため適用範囲が広く、地域の保健事業や在宅でのリハビリテーション等での活用が期待できる。また、本質問紙は4項目だけで転倒の判別力が71.3%と高く、潜在的な転倒リスクを有する高齢者をスクリーニングするための妥当性の高い有用なツールとなり得ることから、本研究の意義は大きいものと考える。
高齢者における歩行時の筋の同時活動は転倒恐怖感と関連がある

永井宏達, 山田実, 竹岡亨, 田中武一, 上村一貴, 山田陽介, 市橋則明, 坪山直生

理学療法学Supplement　2009　(0)　E1Sh2004-E1Sh2004　2010
Publisher: 公益社団法人日本理学療法士協会
ISSN： 0289-3770

eISSN： 2189-602X
加齢に伴う筋のco-activationの増加は姿勢制御能力と関連する

永井宏達, 山田実, 田中武一, 上村一貴, 山田陽介, 市橋則明, 坪山直生

近畿理学療法学術大会　2010　(0)　26-26　2010
Publisher: 社団法人日本理学療法士協会近畿ブロック

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【目的】 主動作筋と拮抗筋が同時に活動することを筋の同時活動(co-activation)という．一般に関節に生じる過剰な同時活動は「力み」として表現される．これまで高齢者においては，最大筋力発揮時に主動作筋に対する拮抗筋の活動が増大していることが報告されており，筋出力低下の因子の一つとして説明されている．また，姿勢制御場面での同時活動としては，加齢による立位・歩行時の同時活動の増大が生じる可能性が示唆されている． 姿勢制御場面での適切な同時活動の増大は、関節の固定性を高め，動作の安定性を向上させるというメリットがある反面、エネルギー効率を低下させるとされている．また，過剰な同時活動の増大は，スムーズな動作遂行を阻害し，例えば高齢者の転倒発生を助長する可能性があることから、同時活動を定量化し、姿勢制御能力の一つとして評価することは重要である。 しかしながら、これらの同時活動と、姿勢制御能力との関連は明らかにされておらず、加齢に伴いどのような変化が生じているのかは不明である。本研究では，若年者と高齢者の姿勢制御時の同時活動を測定し、加齢による影響と、姿勢制御能力と同時活動の関連を明らかにすることを目的とした。 【方法】 対象は地域在住・施設入所高齢者46名(82.0±6.8歳)、健常若年者34人(22.1±2.3歳)とした．なお，整形外科的疾患，神経学的疾患を有するもの，重度の認知症症状を有する対象者は除外した．同時活動の測定には表面筋電図(Telemyo2400: Noraxon社製)を用い，利き足の前脛骨筋とヒラメ筋の筋活動を導出した(サンプリング周波:1500Hz)．測定動作は、静的姿勢制御として静止立位、動的姿勢制御として安定性限界（前・後）、ファンクショナルリーチ（以下FR）、自由歩行を測定した。筋電図の測定は、静止立位、安定性限界、FRについては安定した３秒間を、歩行については、フットスイッチセンサーより同定した3歩行周期とした．また、立位時の重心動揺、安定性限界の重心移動距離の測定には、床反力計(kistler 9286: kistler社製)を使用した。筋電信号は全波整流化，50msecウインドウでのRoot mean squareによる平滑化処理を行った後，それぞれの筋の最大等尺性収縮を100%とした正規化を行った．正規化された筋電図波形より，Falconerらの推奨する同時活動指標であるCo-contraction index(CI)を用いた．統計解析には、若年群と高齢群の姿勢制御能力、CIを比較するため、正規分布の確認できた変数についてはt検定、正規分布していない変数についてはMann Whitney U検定を使用した。また、各群の姿勢制御能力とCIの関係をSpeamanの順位相関係数を用いて分析した。統計学的有意水準は5%未満とした． 【説明と同意】 対象者には研究の内容を紙面上にて説明した上，同意書に署名を得た．なお本研究は本学の倫理委員会の承認を得ている． 【結果】 姿勢制御能力については、すべての項目で若年群が高齢群よりも優れた成績を示した(p<0.001)。筋の同時活動については、安定性限界の後方以外のすべての項目において、高齢群の方が若年者よりも高い値を示した(p<0.01)。姿勢制御能力と同時活動との関連では、高齢群において安静立位(r=0.42, p<0.05)、FR(r=-0.52, p<0.05)で、有意な相関を認めた。安定性限界の前方でも同様の傾向がみられた(r=-0.33, p=0.06)。若年群では、すべての項目で有意な相関を認めなかった。 【考察】 本研究の結果、高齢者は若年者よりも姿勢制御場面において高い同時活動を示すことが明らかになった。このことは、加齢に伴い、姿勢制御場面では同時活動を高めるという代償的戦略を用いることを示唆している。また、姿勢制御能力の低下した高齢者ほど、足関節の同時活動が高いという関係がみとめられた。このことは、姿勢制御能力の低下した高齢者ほど、同時活動を高める戦略をとっていることを示している。これら同時活動の増大は、関節の固定性を高めることで安定化を図るというポジティブな影響があると考えられる。しかし一方で、関節の自由度を制限することで、バランス能力を制限しているというネガティブな影響もある可能性がある。 【理学療法研究としての意義】 同時活動の増大は一種の適応反応であると考えられる。しかし、それが過剰になる、もしくはあらゆる状況で同時活動を高める姿勢制御戦しか選択できないとすると、同時活動を高める戦略では対応できない場面で、動作の制限や転倒リスクの増大につながる可能性が考えられる。臨床場面では、バランス能力の低下した患者に対してリハビリテーションを行う際には、適切な同時活動の獲得、過剰な同時活動の排除、環境に適応した同時活動戦略を選択する能力を獲得していくことが安定性の向上に重要であるかもしれない。
363）自立・虚弱高齢女性における体内水分量と腋窩皮膚水分の関連

仲前美由紀, 岡山寧子, 木村みさか, 山田陽介

日本看護研究学会雑誌　33　(3)　3_316-3_316　2010
Publisher: 一般社団法人日本看護研究学会
ISSN： 2188-3599
362）自立高齢女性における体内水分量と体力との関連

山縣恵美, 小松光代, 木村みさか, 岡山寧子, 山田陽介

日本看護研究学会雑誌　33　(3)　3_316-3_316　2010
Publisher: 一般社団法人日本看護研究学会
ISSN： 2188-3599
擬似妊婦の歩行動作は妊婦の歩行動作をシミュレートする

青山宏樹, 山田陽介, 楠本秀忠, 小田伸午

体力科学　58　(6)　934　2009/12/01

ISSN： 0039-906X
京都府中学校野球チームのメディカルチェック

松井知之, 森原徹, 木田圭重, 東善一, 高島誠, 瀬尾和弥, 山田陽介, 北條達也, 長谷斉

体力科学　58　(6)　774-774　2009/12/01
Publisher: (一社)日本体力医学会
ISSN： 0039-906X

eISSN： 1881-4751
精神障害者における運動処方:自律神経活動からの検討

藤林真美, 石井千恵, 木村哲也, 山田陽介, 田中斉太郎, 赤松裕訓, 森谷敏夫

体力科学　58　(6)　777-777　2009/12
Publisher: (一社)日本体力医学会
ISSN： 0039-906X

eISSN： 1881-4751
最近の女子大生の体格・体力の特徴(看護系大学における15年間の変遷から)

木村みさか, 山田陽介

体力科学　58　(6)　658　2009/12/01

ISSN： 0039-906X
高酸素環境下での運動中の周辺視野反応時間

安藤創一, 山田陽介, 小田伸午, 國部雅大

体力科学　58　(6)　742　2009/12/01

ISSN： 0039-906X
加齢によって姿勢制御時の筋の同時活動は増大する

永井宏達, 山田実, 竹岡亨, 田中武一, 上村一貴, 大明篤史, 高島慎吾, 山田陽介, 池添冬芽, 市橋則明, 坪山直生

体力科学　58　(6)　752-752　2009/12/01
Publisher: (一社)日本体力医学会
ISSN： 0039-906X

eISSN： 1881-4751
高齢者の体格・体力の加齢変化(7年間の縦断的観察より)

水田千夏, 水野順子, 山田陽介, 小松光代, 岡山寧子, 木村みさか

日本公衆衛生学会総会抄録集　68th　477　2009/10/15

ISSN： 1347-8060
様々な対象に適用できる簡易身体活動量評価法(女子大生及び大学女子ランナーでの検討)

走井裕香子, 山田陽介, 安藤創一, 木村みさか

肥満研究　15　(Supplement)　239　2009/09/17

ISSN： 1343-229X
Lacrosseにおける非利き腕での投動作の正確性

荒木真徳, 山田陽介, 小田伸午

体育の科学　59　(7)　508　2009/07/01

ISSN： 0039-8985
接地中の膝・足関節の屈伸動作と中長距離パフォーマンス,走動作,下肢筋厚の関係

岡本英也, 山田陽介, 小田伸午

体育の科学　59　(7)　509　2009/07/01

ISSN： 0039-8985
A strategy for preservation of motor function without increasing risks in frail elderly people: A pilot study

K. Nagai, T. Inoue, Y. Yamada, H. Tateuchi, T. Ikezoe, N. Ichihashi, T. Tsuboyama

BONE　44　(2)　S447-S447　2009/06

DOI： 10.1016/j.bone.2009.03.417 　

ISSN： 8756-3282
Training in a seated position for frail elderly people. Peer-reviewed

Nagai K, Inoue T, Yamada Y, Tateuchi H, Ikezoe T, Ichihashi N, Tsuboyama T

10 ? me R?union de l' Association France-Japon d' Orthop?die　2009/04/01
児童を対象とした加速度計によるエネルギー消費量測定法の妥当性

中江悟司, 石井好二郎, 山田陽介, 木村みさか, 鈴木和弘, 小澤治夫

体力科学　58　(2)　328　2009/04/01

ISSN： 0039-906X
日本の子どもにおける身体活動・運動の行動目標設定と効果の検証 1‐2 児童におけるエネルギー消費量と肥満および体力との関連

中江悟司, 山田陽介, 木村みさか, 鈴木和弘, 小澤治夫, 石井好二郎

日本体育協会スポーツ科学研究報告集　2008　13-16　2009/03/31
二重標識水法による児童のエネルギー消費量と肥満度および体力との関連

中江悟司, 山田陽介, 木村みさか, 鈴木和弘, 小澤治夫, 石井好二郎

日本発育発達学会大会抄録集　7th　72　2009/02/17
高齢者に適用できる精度の高い身体活動量評価方法の提案

山田陽介, 走井裕香子, 木村みさか, 小田伸午

健康支援　11　(1)　110　2009/02/01

ISSN： 1345-0174
毎年継続してきた高齢者を対象にした体力測定の試み

木村みさか, 山田陽介

健康支援　11　(1)　103　2009/02/01

ISSN： 1345-0174
2-P-45 Relationships of the physical activity level with obesity and physical fitness in children : Results of a survey in 3rd to 5th graders(The Proceedings of the 17th Annual Meetings of Japan Society of Exercise and Sports Physiology Jury 25-26, (Tokyo)) :

KIMURA Misaka, YAMADA Yosuke

Advances in exercise and sports physiology　15　(2)　93-93　2009
Publisher: Japan Society of Exercise and Sports Physiology
ISSN： 1340-3141
THE PEOPLE WITH TENDENCY OF DEPRESSION HAVE REDUCED AUTONOMIC NERVOUS SYSTEM ACTIVITY IN JAPANESE APPARENTLY HEALTHY PEOPLE

Mami Fujibayashi, Tamaki Matsumoto, Tetsuya Kimura, Yosuke Yamada, Toshio Moritani

JOURNAL OF PHYSIOLOGICAL SCIENCES　59　516-516　2009

ISSN： 1880-6546
運動中になぜ周辺視野での反応の早さが低下するのか?

安藤創一, 山田陽介, 國部雅大

日本運動生理学会大会プログラム・抄録集　17th　67　2009
細胞外区画の相対的な増加が高齢者の体肢骨格筋量を過大評価する

山田陽介, 森本武利, 木村みさか

日本運動生理学会大会プログラム・抄録集　17th　77　2009
こどもの身体活動量と肥満・体力―小学3年生から5年生における調査結果―

木村みさか, 山田陽介

日本運動生理学会大会プログラム・抄録集　17th　85　2009
都立豊島病院における緩和医療について

山田陽介, 伊藤恵子, 景山明彦

お茶の水医学雑誌　56　(2/4)　60　2008/12/15

ISSN： 0472-4674
各種簡便法による高齢者の身体活動量推定の妥当性(活動記録および食事摂取記録を用いた場合)

走井裕香子, 糸井亜弥, 山田陽介, 木村みさか

体力科学　57　(6)　759-759　2008/12/01
Publisher: 日本体力医学会
ISSN： 0039-906X
254. 各種簡便法による高齢者の身体活動量推定の妥当性 : 活動記録および食事摂取記録を用いた場合(代謝,一般口演,第63回日本体力医学会大会)

走井裕香子, 糸井亜弥, 山田陽介, 木村みさか

体力科學　57　(6)　759-759　2008/12/01
Publisher: 日本体力医学会
ISSN： 0039-906X
脳卒中患者における廃用性に伴う筋萎縮の経時的非侵襲的評価

鈴木里美, 山田陽介

日本看護科学学会学術集会講演集　28th　518　2008/11
模擬微小重力暴露後により生ずる体液移動への対抗措置の効果

櫻井博紀, 岩瀬敏, 菅屋潤壹, 増尾義久, 西村直記, 山田陽介, 太田めぐみ, 富田真司, 福永哲夫, 石田浩司, 秋間広, 片山敬章, 清水祐樹, 佐藤麻紀, KANIKOWSKA Dominika, 鈴木里美, 渡邉順子, 平柳要, 塩沢友規

日本宇宙航空環境医学会大会プログラム・予稿集　54th　43　2008/10/17
生活行為向上を目的とした運動プログラム(デイサービス利用者での試み)

木村みさか, 田中甲子, 村井千賀, 山田陽介

日本公衆衛生学会総会抄録集　67th　513　2008/10/15

ISSN： 1347-8060
足趾に着目したトレーニングが高齢者の運動機能におよぼす影響―安全に実施できる非監視型トレーニングの効果―

永井宏達, 井上拓也, 山田陽介, 太田恵, 小栢進也, 佐久間香, 塚越累, 福元喜啓, 今野亜希子, 建内宏重, 池添冬芽, 市橋則明, 坪山直生

Osteoporosis Japan　16　(Suppl.1)　132-132　2008/10/01
Publisher: ライフサイエンス出版(株)
ISSN： 0919-6307
徒歩通学はこどもの活動量と肥満に関係する(徒歩通学時間の異なる小学校6年生における比較)

木村みさか, 糸井亜弥, 山田陽介

肥満研究　14　(Supplement)　241　2008/09/22

ISSN： 1343-229X
Autonomic nervous system activity and aging in mental disorders

Mami Fujibayashi, Seitaro Tanaka, Chie Ishii, Ikuko Kishida, Norio Ishii, Yosuke Yamada, Toshio Moritani, Seishin-kai

JOURNAL OF AGING AND PHYSICAL ACTIVITY　16　S48-S48　2008/07

ISSN： 1063-8652
Characteristics of physical activities and nutritional intake in elderly volunteers

Aya Itoi, Yasuko Okayama, Keiko Fukuroku, Yosuke Yamada, Misaka Kimura

JOURNAL OF AGING AND PHYSICAL ACTIVITY　16　S60-S61　2008/07

ISSN： 1063-8652
A supporter training program for community disability prevention in enfeebled elderly people

Misaka Kimura, Yasuko Yoshinaka, Mitsuyo Komatsu, Keiko Fukuroku, Yosuke Yamada, Yasuko Okayama

JOURNAL OF AGING AND PHYSICAL ACTIVITY　16　S171-S171　2008/07

ISSN： 1063-8652
Disability prevention for enfeebled elderly people using day service

Yasuko Okayama, Misaka Kimura, Mitsuyo Komatsu, Chinatsu Mizuta, Keiko Fukuroku, Yasuko Yoshinaka, Yosuke Yamada

JOURNAL OF AGING AND PHYSICAL ACTIVITY　16　S181-S181　2008/07

ISSN： 1063-8652
頸髄損傷者の筋萎縮と体組成について

田中利明, 山田陽介, 大畑光司, 矢部京之助

リハビリテーションスポーツ　27　(1)　17-17　2008/06/30
Publisher: 医療体育研究会
ISSN： 1347-1201
頸髄損傷者の筋萎縮と体組成について(障害者スポーツ発祥の地から未来に向けたメッセージ,<特集>第28回医療体育研究会/第11回日本アダプテッド体育・スポーツ学会第9回合同大会)

田中利明, 山田陽介, 大畑光司, 矢部京之助

リハビリテーションスポーツ　27　(1)　17-17　2008/06/30
Publisher: 医療体育研究会
ISSN： 1347-1201
Energy Expenditure In The Elderly Estimated By Uniaxial And Triaxial Accelerometers And Doubly Labeled Water

Yosuke Yamada, Keiichi Yokoyama, Yasuko Okayama, Yukako Hashii, Shingo Oda, Misaka Kimura

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE　40　(5)　S328-S328　2008/05

ISSN： 0195-9131
Head‐down bed restにより生ずる体液移動と筋萎縮への対抗措置の効果

櫻井博紀, 岩瀬敏, 菅屋潤壹, 増尾善久, 西村直記, 山田陽介, 太田めぐみ, 富田真司, 福永哲夫, 石田浩司, 秋間広, 片山敬章, 清水祐樹, 佐藤麻紀, KANIKOWSKA Dominika, 鈴木里美, 渡邉順子, 平柳要, 塩澤友規

宇宙利用シンポジウム　24th　278-280　2008/03
簡易な動作計測機器による運動機能の推定手法の検討

松村吉浩, 川口亜紀, 横山慶一, 山田陽介, 小田伸午

日本生体医工学会大会プログラム・論文集(CD-ROM)　47th　ROMBUNNO.PS2-4-18　2008
Effect of countermeasure on body fluid shift and myatrophy induced by head-down bed rest in human healthy volunteers

Sakurai Hiroki, Ishida Koji, Akima Hiroshi, Katayama Keisyou, Shimizu Yuuki, Sato Maki, Dominika Kanikowska, Suzuki Satomi, Watanabe Yoriko, Hirayanagi Kaname, Shiozawa Tomoki, Iwase Satoshi, Sugenoya Junichi, Masuo Yoshihisa, Nishimura Naoki, Yamada Yosuke, Ohta Megumi, Tomita Shinji, Fukunaga Tetsuo

Proceedings of Annual Meeting of the Physiological Society of Japan　2008　(0)　108-108　2008
Publisher: PHYSIOLOGICAL SOCIETY OF JAPAN

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Exposure of humans to microgravity condition resulted in body fluid shift and myatrophy. The aim of this study was to test the effectiveness of artificial gravity and ergometric exercise as countermeasure to these changes. 12 healthy young men were exposed to stimulated microgravity for 20 days by head-down bed rest. 6 subjects randomly selected were subjected to 1.4G of artificial gravity with 60W of ergometric workload everyday for 30 minutes (CM group). The rest of the subjects served as the control (control group). In head-up tilt test and Anti-G test, body fluid shift measured by segmental bioimpedance method was smaller in the trunk in CM group than in control group. Also, myatrophy measured by MRI in the thigh was smaller in CM group than in control group. Artificial gravity with exercise appeared to be effective in preventing changes in body fluid shift and myatrophy due to microgravity exposure. [J Physiol Sci. 2008;58 Suppl:S108]
自家用車送迎の多い東北農村地域における小学生の肥満と身体活動量および食生活

木村みさか, 糸井亜弥, 山田陽介, 佐藤泉

日本公衆衛生学会総会抄録集　66th　471-472　2007/10/15

ISSN： 1347-8060
3軸加速度計,1軸加速度計と歩数計の身体活動量評価に加齢が与える影響

山田陽介, 糸井亜弥, 水田千夏, 木村みさか

肥満研究　13　(Supplement)　207　2007/09/20

ISSN： 1343-229X
自家用車通学で肥満が高頻度で認められた農村地域児童のその後:中学での体型変化

木村みさか, 糸井亜弥, 山田陽介

肥満研究　13　(Supplement)　253　2007/09/20

ISSN： 1343-229X
二重標識水法を用いた児童における簡易エネルギー消費量推定法の検討

中江悟司, 山田陽介, 木村みさか, 鈴木和弘, 小澤治夫, 石井好二郎

肥満研究　13　(Supplement)　261　2007/09/20

ISSN： 1343-229X
老化および身体能力と筋量の大腿下腿比および左右差との関連(高齢者,高齢者、障害者、低体力者のからだとこころと運動,オーガナイズドセッションC,本部企画)

山田陽介, 小田伸午, 増尾喜久, 木村みさか

日本体育学会大会予稿集　58　(58)　18-18　2007/09/05
Publisher: 社団法人日本体育学会
DOI： 10.20693/jspehss.58.18_1 　
05-7-K301-14 野球のピッチング中の投球腕の軌道は投球分布に影響を与える(05.バイオメカニクス,一般研究発表抄録)

土屋真司, 山田陽介, 小田伸午

日本体育学会大会予稿集　58　(58)　216-216　2007/09/05
Publisher: 社団法人日本体育学会
DOI： 10.20693/jspehss.58.216_3 　
各種簡便法による高齢者の身体活動量

木村みさか, 山田陽介

老年社会科学　29　(2)　287　2007/06/10

ISSN： 0388-2446
加齢・身体機能低下に伴う骨格筋変化の非侵襲的評価―57‐96歳までの健常・要介護高齢者の下肢筋の特徴―

山田陽介, 横山慶一, 木村みさか, 小田伸午

体育の科学　57　(6)　483　2007/06/01

ISSN： 0039-8985
スピード持久力に優れる800mランナーは接地中の身体重心水平方向移動距離が長い

岡本英也, 山田陽介, 小田伸午

体育の科学　57　(6)　486　2007/06/01

ISSN： 0039-8985
スポーツ実習の受講生を対象としたライフスキルの検討

来田宣幸, 山本剛, 山田陽介, 小田伸午

体育の科学　57　(6)　484　2007/06/01

ISSN： 0039-8985
PA3-8 Characteristics of Physical Abilities in Frail Elderly People(Proceedings of The 8th International Congress of Physiological Anthropology) :

KIMURA Misaka, OKAYAMA Yasuko, YAMADA Yosuke

Journal of physiological anthropology　26　(2)　295-296　2007
Publisher: Japan Society of Physiological Anthropology
野球のピッチング中の投球腕の軌道は投球分布に影響を与える

土屋真司, 山田陽介, 小田伸午

日本体育学会大会予稿集　58th　216-216　2007
Publisher: 社団法人日本体育学会
DOI： 10.20693/jspehss.58.216_3 　
老化および身体能力と筋量の大腿下腿比および左右差との関連

山田陽介, 小田伸午, 増尾喜久, 木村みさか

日本体育学会大会予稿集　58th　18-18　2007
Publisher: 社団法人日本体育学会
DOI： 10.20693/jspehss.58.18_1 　
多周波数インピーダンス法を用いた大腿部体組成評価:‐超音波診断装置より求めた筋厚との関連‐

井上拓也, 大畑光司, 山田陽介, 市橋則明

近畿理学療法学術大会　2007　(0)　15-15　2007
Publisher: 社団法人日本理学療法士協会近畿ブロック

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【目的】生体電気抵抗法(bioelectrical impedance method:以下BI法)は、生体に微弱な交流電流を通電して抵抗を測定し身体組成を評価するものであり、単周波数BI法と多周波数BI法がある。BI法による測定は単周波数BI法での測定が一般的で、多周波数BI法での測定は少ない。多周波数BI法の特徴は細胞内液抵抗と細胞外液抵抗を別々に測定できることであり、心臓手術を含めた外科手術後患者などの身体組成評価法として有効とされている。しかし、多周波数BI法を使って四肢の身体組成を評価した報告は少なく、さらに多周波数BI法と筋厚との関連についての報告はほとんどない。 本研究の目的は、多周波数BI法により求めた大腿部の細胞内液量(intra-cellular water:以下ICW)、細胞外液量(extra-cellular water:以下ECW)と大腿前面の筋厚との関連について検討することである。 【対象】大学ラグビー部に所属する男性17名(平均年齢20.5±1.2歳)を対象とした。対象者には本研究の目的を説明し同意を得た。 【方法】ICW、ECW及び筋総体積(total body water:以下TBW)の測定には多周波数方式体脂肪計(積水化学工業社MLT-30)を用いた。計測部位は右大腿部とし、電流電極を手背中央部・足背中央部の2箇所に、電圧電極は上前腸骨棘・膝関節裂隙-腓骨頭間の2箇所に貼付した。ICWとECWを足し合わせたものをTBWとして、TBWに対するICWの水分比率(ICW/TBW)を算出した。筋厚の測定には、超音波診断装置（GE横河メディカルシステム製）を用いた。測定部位は外側広筋と中間広筋を含む大腿外側部(以下:外側部)、大腿直筋と中間広筋を含む大腿中央部(以下:中央部)の2箇所とし、いずれも右側のみとした。 ICW、ECW、TBW、ICW/TBWと各筋厚との関連性を調べるためにPearsonの相関係数を求めた。統計学的有意水準は危険率5%未満とした。 【結果】ICWと外側部の筋厚(r=0.66，p<0.01)、TBWと外側部の筋厚(r=0.60，p<0.05)、ICW/TBWと外側部の筋厚(r=0.71，p<0.01)は有意な相関を示したが、ECWと外側部の筋厚(r=－0.13)において相関はなかった。また、ICWと中央部の筋厚(r=0.54，p<0.05)、ICW/TBWと中央部の筋厚(r=0.60，p<0.05)は有意な相関を示したが、TBWと中央部の筋厚(r=0.48)及びECWと中央部の筋厚(r=－0.17)において相関はなかった。 【考察】ICWは筋細胞量を反映しており、ECWは細胞間隙にある水分量を反映する。つまり、ICWは筋実質の量を表し、ECWは筋の実質以外の水分量を表すと言える。よって、ICWが筋厚と有意な相関を示す一方で、ECWは相関を示さなかったものと考えられる。本研究より、多周波数BI法は大腿部のみの測定であっても、筋厚との関連性があり、本評価法の妥当性が示唆された。
64歳~87歳の健康な日本人高齢者の身体活動量(二重標識水による総エネルギー消費量)

木村みさか, 山田陽介, 横山慶一, 岡山寧子, 森本武利, 足立哲司

体力科学　55　(6)　689-689　2006/12/01
Publisher: 日本体力医学会
ISSN： 0039-906X
高齢者の歩調ゆらぎと筋力・バランス能力・柔軟性の連関

横山慶一, 山田陽介, 木村みさか, 松村吉浩, 川口亜紀, 小田伸午

体力科学　55　(6)　744-744　2006/12/01
Publisher: 日本体力医学会
ISSN： 0039-906X
221. 64歳〜87歳の健康な日本人高齢者の身体活動量 : 二重標識水による総エネルギー消費量(代謝, 第61回日本体力医学会大会)

木村みさか, 山田陽介, 横山慶一, 岡山寧子, 森本武利, 足立哲司

体力科學　55　(6)　689-689　2006/12/01
Publisher: 日本体力医学会
ISSN： 0039-906X
331. 高齢者の歩調ゆらぎと筋力・バランス能力・柔軟性の連関(加齢・性差, 第61回日本体力医学会大会)

横山慶一, 山田陽介, 木村みさか, 松村吉浩, 川口亜紀, 小田伸午

体力科學　55　(6)　744-744　2006/12/01
Publisher: 日本体力医学会
ISSN： 0039-906X
3軸加速度計による高齢者の運動量の推定

山田陽介, 木村みさか, 鈴木明宏, 早坂弘, 松永徹平, 大瀧保明, 猪岡光, 石井賢治, 張秀敏, 永富良一, 小田伸午

日本公衆衛生学会総会抄録集　65th　428-428　2006/10/15
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
健常高齢者の歩行リズムおよび指タップリズムの解析

横山慶一, 山田陽介, 尾崎禎亮, 則安梨才, 松村吉浩, 川口亜紀, 木村みさか, 小田伸午

体力科学　55　(3)　354-354　2006/06/01
Publisher: The Japanese Society of Physical Fitness and Sport Medicine
ISSN： 0039-906X
16. Analysis of stride rhythm and finger-tapping rhythm of the healthy elderly

YOKOYAMA KEIICHI, YAMADA YOSUKE, OSAKI TOMOAKI, NORIYASU RISA, MATSUMURA YOSHIHIRO, KAWAGUCHI AKI, KIMURA MISAKA, ODA SHINGO

Japanese Journal of Physical Fitness and Sports Medicine　55　(3)　354-354　2006/06/01
Publisher: 日本体力医学会
ISSN： 0039-906X
退職による身体活動量の変化が高血圧,高脂血症および糖尿病の発症に与える影響 (第6回運動疫学セミナー開催報告) -- (演習レポート)

山本直史, 荒井弘和, 山田陽介

運動疫学研究　8　69-73　2006
Publisher: 運動疫学研究会
ISSN： 1347-5827
要介護高齢者のADL低下と下肢の浮腫との関連

山田陽介, 増尾善久, 小田伸午, 西脇友子

体力科学　54　(6)　563　2005/12/01

ISSN： 0039-906X
289.要介護高齢者のADL低下と下肢の浮腫との関連(加齢・性差,一般口演,第60回日本体力医学会大会)

山田陽介, 増尾善久, 小田伸午, 西脇友子

体力科學　54　(6)　563-563　2005/12/01
Publisher: 日本体力医学会
ISSN： 0039-906X
04-26-ダンス-24 下肢筋力・敏捷性・バランス保持能力が高齢者の歩行能力に及ぼす影響(04 運動生理学,一般研究発表)

横山慶一, 山田陽介, 尾崎禎亮, 進矢正宏, 小田伸午

日本体育学会大会予稿集　56　(56)　241-241　2005/11/01
Publisher: 社団法人日本体育学会
DOI： 10.20693/jspehss.56.241_1 　
05-26-総研D-13 三軸加速度計を用いた高齢者の歩行運動の評価(05 バイオメカニクス,一般研究発表)

尾崎禎亮, 山田陽介, 小田伸午, 松村吉浩, 木村みさか

日本体育学会大会予稿集　56　(56)　280-280　2005/11/01
Publisher: 社団法人日本体育学会
DOI： 10.20693/jspehss.56.280_1 　
部位別生体電気インピーダンスと高齢者の身体機能との関連について~浮腫および筋量低下の観点から~

山田陽介, 中村栄太郎, 小田伸午, 増尾善久, 木村みさか

体力科学　54　(2)　195-195　2005/04/01
Publisher: The Japanese Society of Physical Fitness and Sport Medicine
ISSN： 0039-906X
部位別BIAを用いた加齢に伴う下肢筋肉量の低下とバランスの悪化の研究

山田陽介, 増尾善久, 中村栄太郎, 小田伸午

体力科学　53　(6)　778-778　2004/12/01
Publisher: 日本体力医学会
ISSN： 0039-906X
部位別BIAを用いた加齢に伴う下肢筋肉量の低下とバランスの悪化の研究(加齢・性差, 第59回日本体力医学会大会)

山田陽介, 増尾善久, 中村榮太郎, 小田伸午

体力科學　53　(6)　778-778　2004/12/01
Publisher: 日本体力医学会
ISSN： 0039-906X
体幹を捻らない歩行と捻る歩行のバイオメカニクス分析

小田伸午, 山田陽介, 木寺英史, 小山田良治, 上田淳

体力科学　52　(6)　803-803　2003/12/01
Publisher: 日本体力医学会
ISSN： 0039-906X
四肢誘導12電極法を用いた大学競技選手のトレーニング成果の評価

山田陽介, 増尾善久, 小田伸午

体力科学　52　(6)　942-942　2003/12/01
Publisher: 日本体力医学会
ISSN： 0039-906X
178. 体幹を捻らない歩行と捻る歩行のバイオメカニクス分析(バイオメカニクス)

小田伸午, 山田陽介, 木寺英史, 小山田良治, 上田淳

体力科學　52　(6)　803-803　2003/12/01
Publisher: 日本体力医学会
ISSN： 0039-906X
456. 四肢誘導12電極法を用いた大学競技選手のトレーニング成果の評価(形態・体構成)

山田陽介, 増尾善久, 小田伸午

体力科學　52　(6)　942-942　2003/12/01
Publisher: 日本体力医学会
ISSN： 0039-906X

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Books and Other Publications 1

Muscle Mass, Quality, and Composition Changes During Atrophy and Sarcopenia

Yosuke Yamada

Springer Nature　2018/11

ISBN: 9789811314346

Presentations 64

8週間のスクワットトレーニングは大腿部の筋量及び骨格筋細胞量,膝関節伸展筋力及び屈曲筋力を増加させるか?

伊藤真理, 佐藤伸哉, 平田尚哉, 谷本洋樹, 今泉直人, 安藤良介, 山田陽介, 吉田司, 平田浩祐, 平田浩祐, 赤木亮太

日本トレーニング科学会大会プログラム・抄録集　2019/10/12
大阪府摂津市の中高年におけるフレイルの実態:大阪府健康格差解決プログラム促進事業

吉田司, 西信雄, 宮地元彦, 渡邉大輝, 黒谷佳代, 瀧本秀美, 山田陽介, 島田秀和, 澤田奈緒美, 阿部圭一

日本公衆衛生学会総会抄録集　2019/10/10
食事記録を基準とした食物摂取頻度調査の妥当性:高齢者および中高年を対象としたコホート間の比較

渡邉大輝, 渡邉大輝, 南里妃名子, 南里妃名子, 吉田司, 吉田司, 吉田司, 山口美輪, 杉田麻友, 野沢与志津, 岡辺有紀, 糸井亜弥, 後藤千穂, 山田陽介, 山田陽介, 山田陽介, 高田和子, 小林久峰, 木村みさか, 木村みさか

栄養学雑誌　2019/09
COPDにおける身体活動性と関連する臨床指標

赤上巴, 仲村秀俊, 佐藤秀彰, 三尾友彦, 内田義孝, 小宮山謙一郎, 井上快児, 新津守, 永田真, 中江悟司, 西田優紀, 山田陽介, 佐々木敏, 田中茂穂, 勝川史憲

日本呼吸器学会誌(Web)　2019/03/10
日本人COPD患者における二重標識水(DLW)法による総エネルギー消費量測定に基づくエネルギー必要量の推定

佐藤秀彰, 仲村秀俊, 赤上巴, 與儀実大, 相馬真智香, 三尾友彦, 宮下起幸, 永田真, 中江悟司, 西田優紀, 山田陽介, 田中茂穂, 勝川史憲

日本呼吸器学会誌(Web)　2019/03/10
幼児の体力向上と身体活動量・生活習慣との関係の検討

青木好子, 渡邊裕也, 糸井亜弥, 山田陽介, 木村みさか

日本発育発達学会大会抄録集　2019/02/20
都市部小学校3年生における活動量および体力と生活活動時間の関連

糸井亜弥, 糸井亜弥, 青木好子, 山田陽介, 木村みさか

日本発育発達学会大会抄録集　2019/02/20
多周波生体電気インピーダンス法を用いた日本人レスリング選手の体水分量推定の妥当性

塩瀬圭佑, 近藤衣美, 山田陽介, 下山寛之, 西牧未央, 山下大地, 中嶋耕平, 高橋英幸

日本スポーツ栄養研究誌　2019/01/20
高齢者における身体活動量と筋エコー輝度の加齢変化との関連:-4年間の縦断研究-

福元喜啓, 市橋則明, 山田陽介, 池添冬芽, 渡邊裕也, 谷口匡史, 澤野翔一朗, 南征吾, 浅井剛, 木村みさか

理学療法学Supplement　2019

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【はじめに、目的】筋の超音波エコー輝度（以下，筋輝度）は筋内の脂肪・線維組織の程度を示す指標として近年注目されている。加齢により筋輝度が上昇することは多くの横断研究で報告されているが，筋輝度の加齢変化にはどのような因子が影響するかを縦断研究により調べた報告は見当たらない。筋量や筋組成に関連する重要な因子のひとつに身体活動量が知られている。本研究の目的は，高齢者を対象として，身体活動量が筋輝度の加齢変化に及ぼす影響を縦断研究により検討することである。【方法】対象は地域在住で日常生活が自立している60歳以上の高齢者とした。2013年（ベースライン）および2017年（フォローアップ）に，超音波画像診断装置を用いて右下肢の大腿四頭筋の筋厚，筋輝度と同部位の皮下脂肪厚を計測し，右膝関節の最大伸展筋力を測定した。またベースライン時には，質問紙を用いて，身体活動量，糖尿病・変形性膝関節症（膝OA）の有無，飲酒習慣の有無，栄養状態も評価した。身体活動量は，1回30分以上のウォーキング・体操やスポーツを週に2回以上行っているかどうかで2群（高活動群，低活動群）に群分けした。栄養状態は食品摂取多様性スコア（Dietary Variety Score; DVS）を用いて評価した。ベースラインとフォローアップのBMI，脂肪厚，筋厚，筋輝度および筋力を，対応のあるt検定を用いて比較した。また，BMI，脂肪厚，筋厚，筋輝度および筋力の4年間の変化量を算出し，各変化量を目的変数とした重回帰分析を行った。説明変数は，身体活動量（高活動または低活動），年齢，性別，BMI，飲酒，DVS，糖尿病，膝OA，および各目的変数のベースラインの値とした。さらに，筋厚・筋輝度の変化量と筋力の変化量との偏相関を，年齢，性別，BMIで調整したうえで検討した。【結果】対象は，131名（平均年齢72.9歳，男性33名，女性98名）であった。4年間で，高活動群・低活動群とも筋厚，脂肪厚と筋力が有意に減少し（P < 0.05），高活動群では筋輝度が有意に低下したが（P < 0.05），両群のBMIと低活動群の筋輝度には有意な変化がなかった。重回帰分析の結果，高活動は筋厚（β= 0.189, P = 0.031）および筋輝度（β= -3.145, P = 0.045）の変化量に他の説明変数から独立して影響していたが，BMI，脂肪厚と筋力の変化量には影響していなかった。偏相関分析の結果，筋厚・筋輝度の変化量は筋力の変化量には関連していなかった。【考察】本研究の結果，高齢者の身体活動量は筋輝度の縦断変化に影響し，高活動は筋輝度の低下すなわち筋内脂肪・線維組織の減少を引き起こすことが明らかとなった。また低活動であっても高齢期の4年間では筋輝度の上昇は認めにくいことが示唆された。さらに，筋厚および筋輝度と筋力との縦断的な関連性は強くはないことが示唆された。【結論】高齢者における高い身体活動量は筋輝度の縦断的な低下を引き起こすことが示唆された。【倫理的配慮，説明と同意】本研究は，測定機関の倫理委員会の承認を得て実施された。対象者には事前に研究内容を説明し，書面にて研究に参加する同意を得た。
骨格筋における筋厚・筋輝度・細胞外液比の加齢性変化

谷口匡史, 福元喜啓, 山田陽介, 澤野翔一朗, 南征吾, 池添冬芽, 木村みさか, 市橋則明

理学療法学Supplement　2019

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【はじめに、目的】 高齢者の筋力発揮には、骨格筋の量的因子だけではなく質的因子が関連する。骨格筋の質的指標として、筋内脂肪や結合組織の程度を表す筋エコー輝度（筋輝度）が一般に使用される。近年、生体電気インピーダンス分光法（bioelectrical impedance spectroscopy; BIS）を用いた質的評価法が報告されている。BIS法は骨格筋組織内から細胞内液（intracellular water; ICW）と細胞外液（extracellular water; ECW）に分類し評価する。ICWは収縮組織量、ECWは非収縮組織量を表すことから、ECW/ICW比（細胞外液比）の高値は非収縮組織割合の増加、すなわち筋の質的低下を示す指標とされる。この2つの質的指標は、高齢者の筋力低下に対して独立して関連するため、筋輝度と細胞外液比は異なる質的指標といえる。しかし、加齢による骨格筋変性のうち、量的・質的低下のどちらが先行して生じるのか、また筋輝度・細胞外液比の質的低下に違いがあるかは明らかではない。そこで、本研究の目的は、筋厚と筋輝度、細胞外液比における加齢変化の違いを明らかにすることである。【方法】 地域在住高齢女性349名（平均74.3±5.5歳）および健常若年女性20名（平均21.6±1.8歳）を対象とした。また、超音波画像診断装置（GE Healthcare社製LOGIC e）を用いて、安静背臥位における大腿中央部の横断画像を撮像した。大腿四頭筋の筋厚は大腿直筋・中間広筋の和とした。筋輝度は大腿直筋を解析対象とし、グレースケールにて算出した。さらに、インピーダンス計（SKメディカル社製MLT550）を用い、先行研究に準じて細胞外液比を計測した。加齢変化を検討するため、高齢群を年代毎に60歳代(76名)・70歳代(212名)・80歳代(62名)、若年群の4群に群分けした。筋厚、筋輝度、細胞外液比について年代間の比較には、一元配置分散分析および事後検定を実施した。また、若年群に対する各高齢群のtスコアを算出し、各測定項目の平均値を求めた。【結果】 若年群に比べて70・80歳代の筋厚は、有意に低値を示したが、60歳代では有意差を認めなかった。一方、すべての高齢群の筋輝度・細胞外液比は、若年群に対して有意に高値を示した。すべての高齢群におけるt-scoreは、筋輝度、細胞外液比、筋厚の順に低値を示した。【考察】 筋輝度・細胞外液比の増加は筋厚減少よりも先行して生じ、2つの筋の質的指標の中では細胞外液比よりも筋輝度の増加が大きいことが示唆された。筋輝度は主に筋内脂肪や結合組織量、細胞外液比は主に筋組織内の水分量を反映することから、加齢による筋の質的低下に違いが生じたと考えられる。また、これらの非収縮組織の増加は、筋厚減少を過小評価したと推測される。【結論】 加齢による骨格筋変性は、量的低下よりも質的低下が先行して生じることが明らかとなった。また、筋の質的低下には違いがあり、細胞外液比よりも筋輝度の変化が大きい可能性が示唆された。【倫理的配慮，説明と同意】本研究はヘルシンキ宣言に基づいて計画され、測定施設において倫理委員会の承認を得て実施された。対象者には事前に研究内容を十分に説明し、研究に参加することの同意を書面にて得た。
自主的な実施を目指した介護予防プログラムが適用可能な高齢者像の検討亀岡スタディ

吉田司, 吉田司, 山田陽介, 山田陽介, 木村みさか, 木村みさか

日本体育学会大会予稿集　2019
自立した高齢者における総エネルギー消費量および身体活動レベル

田中茂穂, 高田和子, 中江悟司, 山田陽介, 佐々木敏

日本栄養・食糧学会大会講演要旨集　2018/04/27
5年間の精神ストレスとCRPの関連は,対処行動や社会的支援の変化により異なる

島ノ江千里, 原めぐみ, 西田裕一郎, 南里妃名子, 安方惇, 三好信行, 山田陽介, 桧垣靖樹, 田中恵太郎

日本衛生学雑誌(Web)　2018/03
都市部小学校3年生の活動量と体力との関連

糸井亜弥, 青木好子, 山田陽介, 木村みさか

日本発育発達学会大会抄録集　2018/03/01
郊外の認定こども園5歳児における体力・身体活動量および生活習慣の関係

青木好子, 勝山翔太, 渡邊裕也, 山田陽介, 木村みさか

日本発育発達学会大会抄録集　2018/03/01
都市部幼稚園5歳児における認知機能と体力との関係

満石寿, 青木好子, 渡邊裕也, 山田陽介, 木村みさか

日本発育発達学会大会抄録集　2018/03/01
日常身体活動とPYCARD遺伝子メチル化の縦断的関連

西田裕一郎, 原めぐみ, 桧垣靖樹, 田口尚人, 島ノ江千里, 南里妃名子, 中村和代, 今泉猛, 坂本龍彦, 安方惇, 三好伸幸, 山田陽介, 堀田美加子, 東元健, 副島英伸, 新地浩一, 田中恵太郎

日本疫学会学術総会講演集(Web)　2018/02/01
糖尿病患者の身体活動量の特徴と体組成,体格との関係:日本人の食事摂取基準2020年版に向けて

宮澤伊都子, 森野勝太郎, 布施恵子, 近藤慶子, 大井彰子, 西田香, 栗原美香, 安原祥子, 中西直子, 西田優紀, 中江悟司, 山田陽介, 田中茂穂, 海老根直之, 佐々木敏, 勝川史憲, 佐々木雅也, 卯木智, 前川聡

糖尿病(Web)　2018
糖尿病患者におけるエネルギー消費量及び活動量

栗原美香, 西田香, 大井彰子, 安原祥子, 中西直子, 布施恵子, 森野勝太郎, 卯木智, 前川聡, 近藤慶子, 西田優紀, 中江悟司, 山田陽介, 田中茂穂, 海老根直之, 佐々木敏, 勝川史憲, 佐々木雅也

日本静脈経腸栄養学会雑誌　2018
多周波生体電気インピーダンス法を用いたサルコペニア評価:日本人を対象とした推定式の開発・妥当性・カットオフ値

山田陽介

日本サルコペニア・フレイル学会誌　2018
高齢者のたんぱく質摂取量と包括的フレイルとの関連:Kyoto‐Kameoka Study

南里妃名子, 山田陽介, 吉田司, 岡辺有紀, 野沢与志津, 糸井亜弥, 吉村英一, 渡邉裕也, 山縣恵美, 山口美輪, 横山慶一, 高田和子, 小林久峰, 木村みさか

日本サルコペニア・フレイル学会誌　2018
CPSを基準とした認知機能評価に関連する高齢者の身体機能の特定亀岡スタディ

吉田司, 山田陽介, 木村みさか

日本体育学会大会予稿集　2018
質問紙によるフレイル判定と超音波法を用いた下肢骨格筋の量的・質的指標の関連

渡邊裕也, 吉田司, 山田陽介, 横山慶一, 山縣恵美, 三宅基子, 吉中康子, 岡山寧子, 木村みさか

日本サルコペニア・フレイル学会誌　2017/10/15
地域在住高齢者における魚介類の摂取頻度とフレイルとの関連:Kyoto‐Kameoka Study

山口美輪, 山田陽介, 山田陽介, 南里妃名子, 南里妃名子, 野沢与志津, 吉田司, 渡邊裕也, 山縣恵美, 小林久峰, 木村みさか

日本サルコペニア・フレイル学会誌　2017/10/15
地域在住高齢者における緑茶の摂取頻度とフレイルとの関連:Kyoto‐Kameoka Study

南里妃名子, 南里妃名子, 山田陽介, 山田陽介, 山口美輪, 吉田司, 渡邊裕也, 山縣恵美, 木村みさか

日本サルコペニア・フレイル学会誌　2017/10/15
神経筋の伝達機能を意識した体操と栄養の介入が身体機能に及ぼす影響

吉中康子, 曽我聡子, 太田宣康, 横山慶一, 山田陽介, 木村みさか

日本公衆衛生学会総会抄録集　2017/10/15
地域高齢者を対象とした体力科学的アプローチによる認知症とサルコペニア予防の縦断研究―福岡那珂川研究―車の運転の有無と脳機能の関係

古瀬裕次郎, 池永昌弘, 山田陽介, 武田典子, 森村和浩, 三好伸幸, 栗山緑, 町田由紀子, 寺田久子, 合馬慎二, 坪井義夫, 山田達夫, 山田達夫, 木村みさか, 清永明, 清永明, 田中宏暁, 檜垣靖樹

月刊臨床と研究　2017/09/20
生体内における骨格筋細胞内外液比・筋細胞膜電気生理学性質評価技術およびエネルギー代謝との関係

山田陽介

日本筋学会学術集会プログラム・抄録集　2017/07/03
施設入所高齢者における移乗動作の自立度と移動様式が身体活動量と心身の健康度に及ぼす影響

西田優紀, 中江悟司, 山田陽介, 山口美輪, 近藤衣美, 白土裕之, 平野浩彦, 佐々木敏, 田中茂穂, 勝川史憲

日本老年医学会雑誌　2017/05/25
精神ストレスと睡眠の質の関連における情緒的支援の影響は,就業状況によって異なる

島ノ江千里, 原めぐみ, 西田裕一郎, 南里妃名子, 安方淳, 山田陽介, 桧垣靖樹, 田中恵太郎

日本行動医学会学術総会プログラム・抄録集　2017/03/17
精神ストレスと睡眠の関連におけるストレス防御因子(社会的支援・対処行動)の影響:J‐MICC study SAGA

島ノ江千里, 原めぐみ, 西田裕一郎, 南里妃名子, 安方淳, 山田陽介, 桧垣靖樹, 田中恵太郎

日本疫学会学術総会講演集(Web)　2017/01/25
地域在住自立高齢者における体力健診とその後の介護予防プログラムへの自発的参加者の特徴

山口美輪, 山田陽介, 山田陽介, 吉田司, 吉田司, 南里妃名子, 南里妃名子, 伊達平和, 伊達平和, 糸井亜弥, 糸井亜弥, 木村みさか, 木村みさか

日本疫学会学術総会講演集(Web)　2017/01/25
糖尿病患者におけるエネルギー消費量の実態

大井彰子, 西田香, 栗原美香, 安原祥子, 中西直子, 佐々木雅也, 布施恵子, 森野勝太郎, 卯木智, 前川聡, 近藤慶子, 西田優紀, 中江悟司, 山田陽介, 田中茂穂, 海老根直之, 佐々木敏, 勝川史憲

日本臨床運動療法学会雑誌　2017
地域在住高齢者が安全で手軽に実践できるレジスタンスエクササイズ

渡邊裕也, 山田陽介, 木村みさか

体力科学　2017
高齢者の膝伸展筋力に骨格筋の質的変化が及ぼす影響―筋輝度だけでなく骨格筋細胞外液比が関連する―

谷口匡史, 谷口匡史, 山田陽介, 福元喜啓, 澤野翔一朗, 池添冬芽, 渡邊裕也, 木村みさか, 市橋則明

日本理学療法学術大会(Web)　2017
包括的な老化尺度「迅速老年医学評価(Rapid Geriatric Assessment)」の邦訳とその妥当性

山田陽介, 中江悟司, 西田優紀, 渡邊裕也, 松坂雄亮, 糸井亜弥, 山田実, 佐々木敏, 平野浩彦, 木村みさか, 田中茂穂, 勝川史憲

日本抗加齢医学会総会プログラム・抄録集　2017
地域高齢者を対象とした体力科学的アプローチによる認知症とサルコペニア予防の縦断研究―福岡那珂川研究―身体活動と4年間の認知機能変化の関係

池永昌弘, 森下香澄, 松尾莉子, 古瀬裕次郎, 森村和浩, 山田陽介, 武田典子, 合馬慎二, 坪井義夫, 山田達夫, 上原吉就, 清永明, 桧垣靖樹, 田中宏暁

月刊臨床と研究　2016/12/20
地域高齢者における身体活動量とフレイル(亀岡スタディ活動量調査参加者での検討)

木村みさか, 吉田司, 山田陽介, 渡邊裕也, 山縣恵美, 糸井亜弥, 三宅基子, 岡山寧子, 桝本妙子, 吉中康子

日本公衆衛生学会総会抄録集　2016/10/15
高齢者における野菜・果物摂取頻度と口腔関連QOLとの関連:Kyoto‐Kameoka Study

南里妃名子, 山田陽介, 糸井亜弥, 渡邊裕也, 横山慶一, 吉田司, 吉村英一, 白澤貴子, 落合裕隆, 後藤千穂, 高田和子, 小風暁, 木村みさか

日本公衆衛生学会総会抄録集　2016/10/15
閉じこもり高齢者の各居住地区で行われる体力測定会への参加に影響する要因

山縣恵美, 渡邊裕也, 木村みさか, 山田陽介, 桝本妙子, 糸井亜弥, 三宅基子, 杉原百合子, 小松光代, 岡山寧子

日本公衆衛生学会総会抄録集　2016/10/15
投球動作と関節可動域および新しい下肢・体幹複合評価との関連性について

松井知之, 森原徹, 瀬尾和弥, 東善一, 平本真知子, 来田宣幸, 宮崎哲哉, 甲斐義浩, 幸田仁志, 江藤寿明, 山田陽介, 盛房周平

日本臨床スポーツ医学会誌　2016/10/01
肩肘の投球障害をスクリーニングする質問紙の開発

来田宣幸, 幸田仁志, 甲斐義浩, 松井知之, 東善一, 平本真知子, 瀬尾和弥, 宮崎哲哉, 江藤寿明, 山田陽介, 渡邊裕也, 森原徹

日本臨床スポーツ医学会誌　2016/10/01
投手の球速に関連する因子の検討

平本真知子, 森原徹, 松井知之, 東善一, 瀬尾和弥, 宮崎哲哉, 渡邊裕也, 山田陽介, 来田宣幸, 盛房周平

日本臨床スポーツ医学会誌　2016/10/01
中高生野球選手における投球障害と関節可動域・筋力・質問紙の関係

幸田仁志, 幸田仁志, 来田宣幸, 松井知之, 甲斐義浩, 東善一, 平本真知子, 瀬尾和弥, 宮崎哲哉, 江藤寿明, 山田陽介, 森原徹

日本臨床スポーツ医学会誌　2016/10/01
児童における連続的な座位行動とエネルギー消費量の関係

香村恵介, 中江悟司, 山田陽介, 平川和文, 木村みさか, 鈴木和弘, 小澤治夫, 海老根直之, 石井好二郎

日本発育発達学会大会抄録集　2016/02/15
長期的な自覚ストレスとDNA酸化損傷(尿中8OHdG)との関連は抑うつの高さによって異なる:J‐MICC study SAGA

島ノ江千里, 原めぐみ, 西田裕一郎, 大塚康子, 南里妃名子, 堀田美加子, 安方淳, 三好信行, 山田陽介, LI Yun‐Shan, 河井一明, 葛西宏, 桧垣靖樹, 田中恵太郎

Journal of Epidemiology (Web)　2016/01/21
高齢者における緑茶およびコーヒー摂取頻度と口腔関連QOLとの関連―Kyoto‐Kameoka Study

南里妃名子, 山田陽介, 渡邊裕也, 三宅基子, 横山慶一, 山縣恵美, 白澤貴子, 落合裕隆, 糸井亜弥, 吉田司, 伊達平和, 菊谷武, 吉田光由, 後藤千穂, 高田和子, 小風暁, 木村みさか

Journal of Epidemiology (Web)　2016/01/21
施設入所高齢者を対象とした身体活動レベルの推定における3軸加速度計の妥当性

西田優紀, 中江悟司, 山田陽介, 近藤衣美, 山口美輪, 白土裕之, 平野浩彦, 佐々木敏, 田中茂穂, 勝川史憲

日本臨床運動療法学会雑誌　2016
生体インピーダンス法による除脂肪組織・骨格筋の評価

山田陽介

日本臨床運動療法学会雑誌　2016
地域在住高齢者の認知機能と体力の関係亀岡スタディ

吉田司, 吉田司, 木村みさか, 山田陽介, 来田宣幸, 野村照夫

日本体育学会大会予稿集　2016
高齢者における足関節底屈筋力と立位バランス能力の関係

江間諒一, 江間諒一, 高山浩一, 高山浩一, 山田陽介, 赤木亮太

日本体育学会大会予稿集　2016
飲料と食事の摂取タイミングが水の吸収に及ぼす影響

田中歌, 石川昂志, 下山寛之, 中江悟司, 中江悟司, 山田陽介, 檜垣靖樹, 田中宏暁, 北條達也, 海老根直之

体力科学　2015/12/01
IT端末を用いた身体活動量測定システムの開発

難波秀行, 山口幸生, 山田陽介, 徳島了, 畑本陽一, 下山寛之, 木村みさか, 桧垣靖樹, 田中宏暁

Res Exerc Epidemiol　2013/03/31
亀岡市高齢者コホート研究(Kameoka Study)における参加者の特性~日常生活圏域ニーズ調査から~

三宅基子, 山田陽介, 木村みさか

Res Exerc Epidemiol　2013/03/31
高齢者における骨格筋細胞量と日常生活中の身体活動量との関係―3軸加速度計とS‐BIS法を用いて―

山田陽介, 山田陽介, 檜垣靖樹, 田中宏暁, 木村みさか

体力科学　2012/12/01
食物栄養学科女子学生のボディイメージと身体活動量,栄養素摂取量との関連

糸井亜弥, 山田陽介, 奥野直, 木村みさか

体力科学　2012/12/01
大腿部を主とした有酸素性運動プログラムが高齢者の筋萎縮抑制に与える影響

三好伸幸, 森村和浩, 武田典子, 山田陽介, 桧垣靖樹, 田中宏暁

体力科学　2012/12/01
二重標識水法を基準にしたIT端末を用いた身体活動測定の妥当性

難波秀行, 山口幸生, 山田陽介, 徳島了, 畑本陽一, 下山寛之, 木村みさか, 桧垣靖樹, 田中宏暁

体力科学　2012/12/01
走行中における180°方向転換時の生理的負荷についての検討―方向転換時におけるエネルギー消費量と走行速度の関係―

畑本陽一, 山田陽介, 市川麻美子, 下山寛之, 桧垣靖樹, 清永明, 田中宏暁

体力科学　2012/12/01
高齢者における座位開閉ステッピング回数と最大10m歩行速度との関係性

田宮創, 横山慶一, 山田陽介, 山田陽介, 吉田司, 吉中康子, 木村みさか

体力科学　2012/12/01
加齢による四肢・体幹筋の量的・質的変化はどの年齢層から始まるのか?

福元喜啓, 池添冬芽, 塚越累, 高木優衣, 山田陽介, 木村みさか, 市橋則明

体力科学　2012/12/01
地域在住高齢者の咀嚼力と体力・筋厚・脂肪厚の関係

横山慶一, 山田陽介, 吉田司, 菊谷武, 吉田光由, 吉中康子, 木村みさか

体力科学　2012/12/01
二重標識水法・重水希釈法運用時における被験者の負担軽減に関する検討

田中歌, 下山寛之, 山田陽介, 山田陽介, 桧垣靖樹, 田中宏暁, 海老根直之

体力科学　2012/12/01
高齢者における有酸素性作業能力,筋量,身体活動レベル,及び栄養の関係

三原里佳子, 池永昌弘, 山田陽介, 高田和子, 田中宏暁, 清永明

体力科学　2012/12/01

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Industrial Property Rights 1

Physical fitness evaluation device, physical fitness assessment method and program

Yosuke Yamada

特許6709462

Property Type: Patent

Holder: National Institutes of Biomedical Innovation, Health and Nutrition

Research Projects 26

老化に伴う水代謝回転速度低下の決定要因と疾患：骨格筋細胞老化の観点から

山田陽介, 國澤純, 保富康宏, 畑本陽一

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(A)

Institution: 国立研究開発法人医薬基盤・健康・栄養研究所

2024/04/01 - 2028/03/31
腸内環境制御による精密栄養の実現を目指したフレイル研究基盤の確立

南里妃名子, 小野玲, 山田陽介, 吉村英一, 國澤純

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(B)

Institution: 国立研究開発法人医薬基盤・健康・栄養研究所

2024/04 - 2028/03
Development of biological aging index focusing on "care-term"

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: National Institutes of Biomedical Innovation, Health and Nutrition

2022/04/01 - 2026/03/31
A novel quantitative assessment of overhydration adjusted a change in the fluid balance with aging in patients undergoing maintenance hemodialysis

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Toho University

2021/04/01 - 2025/03/31
骨格筋機能解析システムを用いた筋力低下要因の解明と個別化トレーニングの効果検証

市橋則明, 谷口匡史, 中井隆介, 山田陽介

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(B)

Category: 基盤研究(B)

Institution: 京都大学

2021/04/01 - 2024/03/31
Biomarkers for early detection of sarcopenia and establishment of new training evaluation technology

Yamada Yosuke

Offer Organization: JSPS

System: Grant-in-Aid for Scientific Research (B) (KAKENHI)

Category: Grant-in-Aid for Scientific Research (B)

Institution: National Institutes of Biomedical Innovation, Health and Nutrition

2018/04 - 2022/03

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The segmental bioelectrical impedance spectroscopy (S-BIS) method, which the principal investigators are developing, is capable of measuring not only the reduction in skeletal muscle cell mass and changes in intramuscular composition associated with sarcopenia, but also changes in the microenvironment inside and outside muscle cells and electrical properties of the muscle cell membrane due to exercise, which cannot be measured using MRI. S-BIS measured muscle capacitance (Cm) and characteristic frequency (fc) were related to surface EMG and contractile properties. This has made it possible to develop a new method of evaluation of training.
Developing a simple stamina test applicable to a wide range of ages and fitness levels performed by either walking or running

Kimura Misaka

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Kyoto University of Advanced Science

2018/04/01 - 2021/03/31

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In this study, we aimed to develop an endurance test that can be performed by either running or walking and can be applied to a wide range of ages or fitness levels (new SST) as a test of whole-body stamina that can be performed indoors simultaneously by many participants in a short time by incorporating the characteristics of the 3-minute 10-m shuttle run test (shuttle stamina test: SSTr) and the shuttle stamina walk test (SSTw), a walking version of SSTr for older or less fit individuals. Using SSTw, the validity of which has been previously confirmed, as a reference, we evaluated age-associated changes in the results of new SST, their relationships with other elements of fitness, and subjectively perceived intensity of the test in 1,216 subjects aged 17-93 years. The results suggest that new SST will be a test of whole-body stamina that can be applied safely to people of a wide range of ages.
The change of physical activity in primary school children for 16 to 20 years

ITOI Aya

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Kobe Women's University

2016/04/01 - 2019/03/31

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We examined physical activity, phisique, lifestyle, food intake by the same method as 20-year before for the sixth grader in urban-areas elementary school. There was no significant difference in percentage of overweight children compared with previously. The physical activity levels was significantly lower compared with 20-year before, there was significantly higher compared with 10-year before. The time of watching television was significantly decreased by about 25%, the time of studying was increased, the intake of calcium was decreased compared with previously. There was no clear that lifestyle was caused by the physical activity levels was significantly lower compared with 20-year before, there was significantly higher compared with 10-year before. Comparison of lifestyle item may be difficult owing to change of time in long-term follow-up study, we should examine these subjects in the future. We were impossible to examination at rural-areas elementary school by reason of school.
Assessment of sarcopenia using electrical properties of skeletal muscle

Yamada Yosuke

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A)

Category: Grant-in-Aid for Young Scientists (A)

Institution: National Institutes of Biomedical Innovation, Health and Nutrition

2015/04/01 - 2018/03/31

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Sarcopenia is defined as age-related loss of skeletal muscle mass and function. Skeletal muscle, in addition to being comprised of a heterogeneous muscle fiber population, also includes extracellular components that do not contribute to positive tensional force production. Here we test segmental bioelectrical impedance spectroscopy (S-BIS) to assess muscle intracellular mass and composition. S-BIS can evaluate electrical properties that may be related to muscle force production. We found that S-BIS measures was more sensitive than traditional methods. Indices of extracellular (noncontractile) and cellular (contractile) compartments in skeletal muscle tissues were determined using the S-BIS measures. Our finding underscores the value of S-BIS to measure muscle composition and suggests that S-BIS should be highly informative in skeletal muscle physiology.
Evaluation of exercise activity of preschool children in reference to DLW-method and its application to the promotion program of exercise activity

Aoki Yoshiko, KIMURA Misaka, Yamada Yousuke, KANEKO Mari, ISONO Makiko, NISHIMURA Makoto

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Kyoto Gakuen University

2015/04/01 - 2018/03/31

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We evaluated the amount of physical activity of preschool children using the Doubly-Labelled Water (DLW) method and the amount of activity necessary for preschool children in relation to physical fitness and lifestyle habits were examined to utilize for the programing at preschool education. The physical activity of preschool children was evaluated using the DLW method, and based on the results, a survey was conducted at nursery schools, kindergartens and certified children’s gardens in several prefectures. Based on the results, physical activity index, number of steps, physical level and the time spent with moderate to vigorous physical activity were determined. In addition, the amount of physical activity for each educational program at the kindergarten was assessed. The results indicated that to satisfy the amount of physical activity necessary for preschool children, it is necessary to incorporate more free time for their voluntary play.
Development of physical activity promotion application linked with GPS and accelerometer

NAMBA Hideyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Category: Grant-in-Aid for Challenging Exploratory Research

2015/04/01 - 2018/03/31

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Physical activity of Japanese people has been declining in recent decades.Using wearable devices might be increase physical activity.The primary objective was to clarify the effect of physical activity promotion through intervention using a wearable device.The second objective was to complement the measurement of physical activity by simultaneous measurement of acceleration and GPS to verify the program of promoting physical activity.In this study, effective wearing of physical activity was not recognized by using only wearable device.It is important to promote behavioral change by feedbacking using GPS, accelerometer, subjective evaluation method using behavior record method, and looking back on internal factors and external factors by SWOT analysis.
Can skeletal muscle echo intensity reflecting muscle composition be used as a new sarcopenia index

Watanabe Yuya, KIMURA Misaka, YOSHINAKA Yasuko, YAMADA Yosuke, IKENAGA Masahiro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Category: Grant-in-Aid for Young Scientists (B)

2015/04/01 - 2018/03/31

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Echo intensity (EI) calculated from skeletal muscle ultrasonography (US) images has been considered to reflect muscle quality. The purpose of this study was to explore the applicability of EI as a sarcopenia / frail index. In the main research, 1,319 older adults (649 men, 670 women) were divided into robust, pre-frail and frail groups, and thus, their front-thigh US data [muscle thickness (MT) and EI] were compared. Significant linear trends were observed in MT and EI for both sex. The findings suggest the utility of EI as a muscle composition index. Because EI can detect the quantitative and qualitative changes in skeletal muscle even at the pre-frail stage, it is expected to be use as a screening tool in the field of preventing frail and long-term care.
Verification of the effects of a preventive care program for homebound older adults developed from a longitudinal study

YAMAGATA EMI, OKAYAMA YASUKO, KOMATSU MITSUYO, SUGIHARA YURIKO, WATANABE YUYA, INOUE TSUNEO, KIMURA MISAKA, YAMADA YOSUKE

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Category: Grant-in-Aid for Young Scientists (B)

Institution: Doshisha Women's College of Liberal Arts

2015/04/01 - 2018/03/31

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This study revealed the actual state of homebound, community-dwelling older adults from a longitudinal study, and developed a preventive care program for the homebound and verified its effects. 13% of older adults who were not homebound were confirmed to be at risk of becoming homebound two years later, and it was shown that social role affects whether or not they have this risk. We developed a preventive care program for the homebound consisting of exercise and social exchange, and intervened in the cases of 22 older adults with tendencies toward becoming homebound. As a result, 80% of the participants showed decreased risk. In addition, it was considered necessary to give homebound older adults personal support, from invitation to participate until completion of a preventive care program for homebound. We need to increase the number of participants and verify the effects of this program.
Development of a method for screening elderly people with high risk of dehydration

Okayama Yasuko, KIMURA MISAKA, KOMATSU MITHUYO, SUGIHARA YURIKO, YAMAGATA EMI, YAMADA YOSUKE, MORIMOTO TAKETOSHI

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

2013/04/01 - 2017/03/31

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In this research, for the prevention of dehydration in elderly people, we investigated the actual condition of the occurrence of dehydration with related living factors and water content of the body in the elderly and evaluated screening methods for increased risk of dehydration and programs for prevention of dehydration . (1) Of the 8,323 elderly people, 4.2% had a history of emergency transport due to heat stroke and a higher percentage of those who lived alone, and showed characteristic living conditions. Therefore, the assessment of entire life of each person is considered necessary for screening of high risk of dehydration. (2) The body water content measured in 405 individuals using S-BIS was positively correlated with body functions. Preventive care is considered necessary to maintain the body water content. (3) Based on the results of (1) and (2), we are evaluating a tentative program for the prevention of dehydration in elderly people applicable to various living situations.
Assessment of sarcopenia by using ultrasound imaging

FUKUMOTO YOSHIHIRO, KIMURA MISAKA, ICHIHASHI NORIAKI, IKEZOE TOME, YAMADA YOSUKE, ASAI TSUYOSHI

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Category: Grant-in-Aid for Young Scientists (B)

Institution: Kobe Gakuin University

2013/04/01 - 2017/03/31

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Muscle thickness was assessed as an index of muscle mass and echo intensity was assessed as an index of intramuscular adipose tissue in older adults by using ultrasound imaging. Study 1 revealed that intramuscular adipose tissue is assosiated with age and exercise habit, but not with physical characteristic or history of smoking. Study 2 revealed that muscle thickness decreased and intramuscular adipose tissue did not change after 3 year follow-up assessment. Change in intramuscular adipose tissue was associated with change in walking ability during 3 years. However, intramuscular adipose tissue was not associated with changes in other physical functions or history of fall.
Non-invasive assessment of skeletal muscle membrane in human

Yamada Yosuke, WATANABE Yuya

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Category: Grant-in-Aid for Challenging Exploratory Research

2014/04/01 - 2016/03/31

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Skeletal muscles contain a large volume of water that is classified into intracellular (ICW) and extracellular (ECW) water fractions. Segmental bioelectrical impedance spectroscopy (S-BIS) is a unique tool used to assess the segmental ratio of ECW/ICW in the limbs. We evaluated 405 community-living people. ECW and ICW in the upper legs were assessed by S-BIS. Isometric knee extension strength (KES), gait speed, and skeletal muscle mass (SM) were measured. Thigh ECW/ICW was negatively correlated with KES and gait speed (r = −0.617 and −0.431, respectively, p < 0.001) and increased with age (p < 0.001). Thigh ECW/ICW was a significant predictor of KES and gait speed independent of age, sex, BMI, and SM. Relative expansion of ECW against ICW in the thigh muscles is a factor in decreased muscle quality and a biomarker of muscle aging.
The relationship between depression and physical activity and physical fitness ( muscle mass ) of the elderly : cross-sectional survey and intervention study

YOSHINAKA YASUKO, KIMURA Misaka, YAMADA Yosuke

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Kyoto Gakuen University

2013/04/01 - 2016/03/31

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For mental health care and depression prevention of the elderly, we intended to grasp people with depressive tendency, verify the effects of the depression prevention program, establish and evaluate the local support system in this study. In a survey of needs in spheres of daily life in Kameoka city, among 13294 (72.9%) valid responses, 4397 (33.1%) had a depression risk. Moreover, physical abilities of people with depression risk were lower than people without depression risk. Then, we verified the effect of a physical exercise program in intervention research, and trained care prevention supporters. In this current, we established NPO Genki-up AGE Project to run Genki-up gymnastic class for local elderly in ten towns in Kameoka. Our physical exercise program was suggested to be effective for depression prevention.
Assessment of skeletal muscle function using membrane capacitance during aging

Kimura Misaka, YAMADA Yosuke

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Kyoto Gakuen University

2013/04/01 - 2016/03/31

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Sarcopenia, age-related loss of skeletal muscle mass, strength, and function, is associated with impaired mobility, increased risk of falls, fractures, metabolic dysfunction and mortality. Many sarcopenia consensus definitions include low appendicular lean mass measured by dual energy x-ray absorptiometry (DXA); however, the association of DXA-measured lean mass with function is weak. Segmental bioelectrical impedance spectroscopy (S-BIS) provides a superior assessment of age-related muscle mass decline that is highly correlated with muscle functional loss. S-BIS measures accounted for ~85% of the age-related decrease in appendicular muscle power compared to only ~49% for DXA measures, and correlated strongly with leg muscle power independent of age. S-BIS measures including characteristic frequency, membrane capacitance, and phase angle, identified a predictive model that explained ~79% of inter-individual variance of leg muscle power.
Formulation and evaluation of physical activity criteria for the prevention of sarcopenia/long-term care applicable to a wide range of elderly

KIMURA Misaka, TANAKA Hiroaki, YAMADA Minoru, YAMADA Yosuke, YOSHINAKA Yasuko

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)

Category: Grant-in-Aid for Scientific Research (A)

Institution: Kyoto Gakuen University

2012/04/01 - 2016/03/31

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We aim to formulate and evaluate physical activity criteria for the prevention of sarcopenia/long-term care applicable to a wide range of elderly people varying in the state of health and living conditions on the basis of data that we previously accumulated. We address this theme specifically by 1) conducting a baseline survey of the state of health, state of living, physical activity level, muscle mass, and fitness level in a large cohort, 2) developing and evaluating practical and effective sarcopenia/long-term care prevention programs, and 3) incorporating health economics indices in the assessment. For this purpose, we have launched a prospective study in a cohort consisting of about 18,000 elderly people in Kameoka City, excluding those with level 3 or higher need for care (Kyoto Kameoka Study).
Evaluation of an intervention program of depression prevention in the elderly: Focussing on the relationship between skeletal muscle mass and depressive symptoms

YAMAGATA EMI, OKAYAMA Yasuko, KIMURA Misaka, YAMADA Yosuke, KOMATSU Mitsuyo, SUGIHARA Yuriko

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Category: Grant-in-Aid for Young Scientists (B)

Institution: Kyoto Prefectural University of Medicine

2012/04/01 - 2015/03/31

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The objectives of this study were to clarify the relationship between skeletal muscle mass and depressive symptoms in the elderly, to develop an intervention program for depression prevention or improvement, and to validate this program. In the relationship between skeletal muscle mass, physical fitness and depressive symptoms in community-dwelling elderly, the depressive group show not only lower skeletal muscle mass but also lower physical fitness compared with non-depressive group. An intervention program including exercise and physical activity promotion with dietary and oral care advice was established. A study was conducted to examine the effect of the program. After the program, depressive symptoms, muscle thickness and physical fitness were significantly improved. This results suggest that this intervention program may be effective for preventing depressive in the elderly.
Establishment physical activity guideline for sarcopenia prevention: precision medicine

Offer Organization: JSPS

System: Grant-in-Aid for JSPS Fellows

2011 - 2013
骨格筋細胞量測定による高齢者の廃用性筋萎縮の早期発見と予防プログラムの効果検証

山田陽介

Offer Organization: 日本学術振興会

System: 科学研究費助成事業若手研究(B)

Category: 若手研究(B)

Institution: 福岡大学

2011/04/28 - 2012/03/31
Oxidative stress-regulated glucose transport in skeletal muscle from training and cast immobilization in mice

HIGAKI Yasuki, TANAKA Hiroaki, KIYONAGA Akira, TOBINA Takuro, SUDO Mizuki, ANDO Soichi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Fukuoka University

2010 - 2012

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Rat skeletal muscle expresses NO synthase and that activity varies among several muscles. We hypothesized that NO as one of reactive oxygen intermediates modulates skeletal muscle glucose transport. First, we tried to make available methods for the model of training and inactivity in mice. Next, to determine if an epigenetic modification of NOS gene involves in mediating glucose transport in skeletal muscle, methylation of cytosines at CpG sites in promoter region of NOS gene was analyzed in these samples. Our results demonstrate that DNA methylation of the NOS promoter may be involved in the regulation of glucose metabolism in skeletal muscle.
Quantitative measurements of contractile elements in appendicular muscles by bioelectrical impedance spectroscopy

YAMADA Yosuke

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up

Category: Grant-in-Aid for Research Activity Start-up

Institution: Fukuoka University

2009 - 2010

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Skeletal muscle is important organ for not only strength exertion, but also metabolism. Thus, it is essential to maintain or improve quantity and quality of skeletal muscle in the elderly. The purpose of the present study is to estimate muscle composition using segmental bioelectrical impedance spectroscopy (S-BIS). S-BIS could be used to estimate muscle cell mass and correlated with muscle strength in lower limb more strongly than muscle volume estimated by imaging methods. The index is decreasing with aging, and thus, would assess the muscle cell atrophy.
Fundamental study on estimated energy requirement for the Japanese : physically handicapped person

EBINE Naoyuki, KIMURA Misaka, TANAKA Hiroaki, YOSHITAKE Yutaka, YAMADA Yousuke, ISHII Koujirou, NAKAE Satoshi, MIYATANI Shuichi, IDA Shinobu, ETANI Yuri, FUJITA Motoaki, ADACHI Minoru, NISHIMOTO Yukiko, MIYAMOTO Akina, TANAKA Uta, KONISHI Nobuko, MIKAMI Shinji

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Category: Grant-in-Aid for Young Scientists (B)

Institution: Doshisha University

2008 - 2010

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The Ministry of Health, Labour and Welfare revises the Dietary Reference Intakes for the Japanese every five years. In order to brush the estimated energy requirement up, this study was planned to acquire the data of total energy expenditure and basal metabolic rate of physically handicapped persons. In addition, ways to improve the methods of measuring daily physical activity were elucidated.
部位別多周波BI法を用いた高齢者の筋量および筋量分布推定の妥当性検討

山田陽介

Offer Organization: 日本学術振興会

System: 科学研究費助成事業特別研究員奨励費

Category: 特別研究員奨励費

Institution: 京都大学

2007 - 2008

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本研究は,新たな方法である部位別多周波インピーダンス分光法(S-BIS)を用いて高齢者の体組成(特に筋量と筋量分布)測定を可能にすることを目的として実施した.目的を達するためには,インピーダンスを部位別に測定する意義と,多周波で測定する意義を別々に明らかにしたうえで,最終的に統合する必要があった.本年度においては,まず,インピーダンスを体肢部位別に計測し,特に体肢の遠位部と近位部とを分けて計測することで,高齢者の全身の体組成の推定精度が向上することを明らかにした.この研究は二重標識水(DLW)を質量分析計で分析する方法を体水分量のリファレンスとしておこなっており,研究成果は国際的な学術雑誌に受理された.次に,多周波で下腿部と大腿部の筋内水分分布を計測した結果を筋力・筋パワーと比較検討し,従来の高齢者の筋量評価の問題点を指摘した.この研究成果も国際的な学術雑誌に投稿し,現在再査読中である.さらに画像法による筋断面積評価と比べた研究においても,S-BISによる体肢筋量推定の妥当性が示された.加えて,DLW法と臭化ナトリウム(NaBr)投与法を用いた細胞内外液量の測定をリファレンスにし,S-BISの細胞内外液測定の推定精度を検証した.本研究から,S-BISでは浮腫などを有する高齢者など,従来体組成を正確に測定することができなかった集団においても筋量や筋量分布を評価できることが示唆された.これらの研究成果を統合すると,高齢者でも適用可能な簡便な筋量と筋量分布測定法の確立が可能になったといえる.

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Teaching Experience 16

Biology and Life Sciences　Kyoto Municipal Horikawa Senior High School
Coaching Studies　Kyoto Gakuen University
Graduation Thesis Writing　Kyoto IKEN College for Medicine and Health
Neurophysiology　Kyoto IKEN College for Medicine and Health
Anatomy and Physiology　Kyoto IKEN College for Medicine and Health
Functional anatomy　Kyoto IKEN College for Medicine and Health
Experimental Exercise Physiology　Kyoto IKEN College for Medicine and Health
Statistics　Osaka ISEN College of Technology & Design
Biology and Life Sciences　Osaka ISEN College of Technology & Design
Chemistry　Osaka ISEN College of Technology & Design
Physics　Osaka ISEN College of Technology & Design
Physiology　Osaka ISEN College of Technology & Design
Motor Control　Kyoto University
Sports Exercise　Kyoto University
Sports Sciences　Kyoto University
Sports Practice　Kyoto University

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