TOHOKU UNIVERSITY Researchers

Research History 1

2025/10 - Present

東北大学農学研究科酵素化学助教

Education 3

東北大学農学研究科

2022/04 - 2025/10
中国大連海洋大学大学院水産養殖研究科水産養殖専攻

2015/09 - 2018/06
中国大連海洋大学水産と生命学部生物技術学科

2011/09 - 2015/06

Professional Memberships 4

日本農芸化学会

- Present
日本糖質学会
日本生化学会
東北糖鎖研究会

Research Interests 1

リコンビナントタンパク質、タンパク質相互作用、レクチン、アルツハイマー、タンパク質相互作用

Research Areas 1

Life sciences / Applied biochemistry /

Awards 2

東北糖鎖研究会第9回箱守仙一郎賞（優秀論文賞）

2025
第 44 回日本糖質学会年会の優秀講演賞ファイナリスト

2025

Papers 2

Insights into the copigmentation effect and mechanism of five carbohydrates on thermal and color stability of mulberry anthocyanins

Qian Li, Xuanran Lin, Zhengguang Wang, Dongxu Xing, Fan Liu, Qingyi Wei, Yuxiao Zou

Food Chemistry　509　148577-148577　2026/04
Publisher: Elsevier BV
DOI： 10.1016/j.foodchem.2026.148577 　

ISSN： 0308-8146
Microcystis viridis NIES-102 Cyanobacteria Lectin (MVL) Interacts with SARS-CoV-2 Spike Protein Receptor Binding Domains (RBDs) via Protein–Protein Interaction

Zhengguang Wang, Zhihan Yang, Mami Shishido, Khadija Daoudi, Masafumi Hidaka, Hiroaki Tateno, Eugene Futai, Tomohisa Ogawa

International Journal of Molecular Sciences　25　(12)　6696-6696　2024/06/18
Publisher: MDPI AG
DOI： 10.3390/ijms25126696 　

eISSN： 1422-0067

More details Close

The emergence of coronavirus disease 2019 (COVID-19) posed a major challenge to healthcare systems worldwide, especially as mutations in the culprit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) complicated the development of vaccines and antiviral drugs. Therefore, the search for natural products with broad anti-SARS-CoV-2 capabilities is an important option for the prevention and treatment of similar infectious diseases. Lectins, which are widely recognized as antiviral agents, could contribute to the development of anti-SARS-CoV-2 drugs. This study evaluated the binding affinity of six lectins (including the cyanobacterial lectin from Microcystis viridis NIES-102 (MVL), and Jacalin, a lectin from the breadfruit, Artocarpus altilis) to the receptor binding domain (RBD) of the spike protein on the original (wild) SARS-CoV-2 and three of its mutants: Alpha, Delta, and Omicron. MVL and Jacalin showed distinct binding affinity to the RBDs of the four SARS-CoV-2 strains. The remaining four lectins (DB1, ConA, PHA-M and CSL3) showed no such binding affinity. Although the glycan specificities of MVL and Jacalin were different, they showed the same affinity for the spike protein RBDs of the four SARS-CoV-2 strains, in the order of effectiveness Alpha > Delta > original > Omicron. The verification of glycan-specific inhibition revealed that both lectins bind to RBDs by glycan-specific recognition, but, in addition, MVL binds to RBDs through protein–protein interactions.

Presentations 5

The Cryo-EM structure of chum salmon CSL2 24-mer lectin and Gb3 complex effectively functions in Aβ reduction targeting Alzheimer's disease.

王正光, 後藤楓, 次田篤史, 楊芷菡, Khadija Daudi, 日高將文, 横山武司, 二井勇人, 田中良和, 小川智久

日本農芸化学会2026年度大会　2026/03/10
MVLレクチンはタンパク質-タンパク質相互作用(PPI)によりコロナウイルススパイクタンパク質受容体結合ドメイン(RBDs)と相互作用する Invited

王正光, 楊芷菡, Khadija Daoudi, 日高將文, 舘野浩章, 二井勇人, 小川智久

第19回東北糖鎖研究会　2025/11/23
Chum salmon lectin CSL2 drives lysosomal targeting of amyloid precursor protein via glycolipid Gb3

王正光, 後藤楓, 次田篤史, 楊芷菡, Khadija Daudi, 日高將文, 横山武司, 二井勇人, 田中良和, 小川智久

2025年度（第7回）日本糖質学会　2025/10/02
Microalgae lectin MVL interacts with SARS-CoV-2 Spike Protein Receptor Binding Domains (RBDs) via Protein–Protein Interaction.

王正光, 楊芷菡, Khadija Daoudi, 日高將文, 舘野浩章, 二井勇人, 小川智久

2024年度日本生化学会第97回大会　2024/11/07
The anti-COVID-19 function research of lectins from microalgae.

王正光, 楊芷菡, 日高將文, 二井勇人, 小川智久

2024年度日本農芸化学会大会　2024/03/27

Industrial Property Rights 1

アミロイドβ産生を抑制するレクチン

Property Type: Patent