Details of the Researcher

PHOTO

Masayuki Kamimura
Section
Tohoku University Hospital
Job title
Senior Assistant Professor
Degree

  • 博士（医学）（東北大学）

Research Areas 1

  • Life sciences / Orthopedics /

Awards 1

  1. Tohoku Society of Orthopaedics and Traumatology Travelling Fellow

    2012/10　Tohoku Society of Orthopaedics and Traumatology

Papers 55

  1. Total Knee Arthroplasty in Patients With Ankle Osteoarthritis Affects Contralateral Ankle Alignment and Postoperative Outcome of Total Knee Arthroplasty. International-journal

    Tomoki Koyama, Yu Mori, Shunsuke Utsumi, Kento Harada, Kentaro Ito, Hidetatsu Tanaka, Takashi Aki, Hideaki Nagamoto, Masayuki Kamimura, Toshimi Aizawa

    Foot & ankle international　10711007241283783-10711007241283783　2024/11/06

    DOI： 10.1177/10711007241283783 　

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    BACKGROUND: This study investigated the impact of total knee arthroplasty (TKA) on the alignment of the ankle joint, focusing on changes in coronal alignment of both ankles. METHODS: This retrospective study, conducted at our hospital, included 64 patients older than 70 years who underwent TKA for varus knee osteoarthritis (OA). Using full-length standing radiographs of both lower extremities taken preoperatively and 6 months postoperatively, we assessed ankle OA grading based on the Takakura-Tanaka classification and measured mechanical hip-knee-ankle (mHKA) and the tibiotalar angle (TTA) on both the surgical and contralateral side. Additionally, we examined the impact of ankle OA on postoperative clinical scores, the Knee injury and Osteoarthritis Outcome Score, following TKA. RESULTS: Based on the classification, ankle OA stage 2 or higher was present in 13 cases on the surgical side and 13 cases on the contralateral side. On the surgical side, mHKA changed from 12.2 to 1.8 degrees varus (P < .001) and TTA from 1.7 to 1.0 degrees varus (P = .002). On the contralateral side, mHKA changed from 4.0 to 5.4 degrees varus (P = .04), and TTA from 2.7 to 3.0 degrees varus (P < .001). In ankle OA stage 2 or higher patients, contralateral TTA changed from 5.2 to 6.5 degrees varus (P < .001) and unchanged in stage 1 patients. Ankle OA stage 2 or higher patients had worse ADL outcomes than stage 1 patients (score: 67.2 and 78.3, respectively, P = .03). CONCLUSION: This study suggests an apparent interrelationship between knee and ankle OA and the potential negative influence of TKA on ankle OA.

  2. TiNbSn Alloy Plates with Low Young's Modulus Modulates Interfragmentary Movement and Promote Osteosynthesis in Rat Femur

    Tomoki Koyama, Yu Mori, Masayuki Kamimura, Hidetatsu Tanaka, Rui Tome, Ketaro Ito, Masashi Koguchi, Naoko Mori, Toshimi Aizawa

    Journal of the Mechanical Behavior of Biomedical Materials　106820-106820　2024/11

    Publisher: Elsevier BV

    DOI： 10.1016/j.jmbbm.2024.106820 　

    ISSN： 1751-6161

  3. Impact of Aging and Knee Osteoarthritis on Lower Limb Alignment and CPAK Classification: Gender Differences in a Japanese Cohort

    Kento Harada, Yu Mori, Masayuki Kamimura, Takashi Aki, Tomoki Koyama, Toshimi Aizawa

    Journal of Clinical Medicine　2024/10/19

    DOI： 10.3390/jcm13206250 　

  4. 低弾性率チタン(TiNbSn)合金製ロッキングプレートはラット大腿骨骨切り部の骨癒合を促進する

    古山 和樹, 森 優, 上村 雅之, 田中 秀達, 伊東 健太郎, 古口 昌志, 原田 健登, 内海 峻輔, 畠山 拡, 正橋 直哉, 相澤 俊峰

    日本整形外科学会雑誌　98　(8)　S1803-S1803　2024/09

    Publisher: (公社)日本整形外科学会

    ISSN： 0021-5325

    eISSN： 2758-7479

  5. A Review of the Impacts of Implant Stiffness on Fracture Healing

    Yu Mori, Masayuki Kamimura, Kentaro Ito, Masashi Koguchi, Hidetatsu Tanaka, Hiroaki Kurishima, Tomoki Koyama, Naoko Mori, Naoya Masahashi, Toshimi Aizawa

    Applied Sciences　2024/03/07

    DOI： 10.3390/app14062259 　

  6. Differences in kinematic parameters during gait between the patients with knee osteoarthritis and healthy controls using an insole with a single inertial measurement unit: A case-control study

    Haruki Yaguchi, Keita Honda, Yusuke Sekiguchi, Chenhui Huang, Kenichiro Fukushi, Zhenwei Wang, Kentaro Nakahara, Masayuki Kamimura, Takashi Aki, Ken Ogura, Shin-Ichi Izumi

    Clinical Biomechanics　106191-106191　2024/01

    Publisher: Elsevier BV

    DOI： 10.1016/j.clinbiomech.2024.106191 　

    ISSN： 0268-0033

  7. TiNbSn stems with gradient changes of Young’s modulus and stiffness reduce stress shielding compared to the standard fit-and-fill stems

    Kazuyoshi Baba, Yu Mori, Daisuke Chiba, Yoshiyuki Kuwahara, Hiroaki Kurishima, Hidetatsu Tanaka, Atsushi Kogure, Masayuki Kamimura, Norikazu Yamada, Susumu Ohtsu, Masamizu Oyama, Naoya Masahashi, Shuji Hanada, Eiji Itoi, Toshimi Aizawa

    European Journal of Medical Research　28　(1)　2023/07/03

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s40001-023-01199-z 　

    eISSN： 2047-783X

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    Abstract Background The difference between Young’s moduli of the femur and the stem causes stress shielding (SS). TiNbSn (TNS) stem has a low Young’s modulus and strength with gradient functional properties during the change in elastic modulus with heat treatment. The aim of this study was to investigate the inhibitory effect of TNS stems on SS and their clinical outcomes compared to conventional stems. Methods This study was a clinical trial. Primary THA was performed using a TNS stem from April 2016 to September 2017 for patients in the TNS group. Unilateral THA was performed using a Ti6Al4V alloy stem from January 2007 to February 2011 for patients in the control group. The TNS and Ti6Al4V stems were matched in shape. Radiographs were obtained at the 1- and 3-year follow-ups. Two surgeons independently checked the SS grade and appearance of cortical hypertrophy (CH). The Japanese Orthopaedic Association (JOA) scores before and 1 year after surgery were assessed as clinical scores. Results None of the patients in the TNS group had grade 3 or 4 SS. In contrast, in the control group, 24% and 40% of patients had grade 3 and 4 SS at the 1- and 3-year follow-ups, respectively. The SS grade was lower in the TNS group than in the control group at the 1- and 3-year follow-ups (p &lt; 0.001). The frequencies of CH in both groups were no significant difference at the 1- and 3-year follow-ups. The JOA scores of the TNS group significantly improved at 1 year after surgery and were comparable to control group. Conclusion The TNS stem reduced SS at 1 and 3 years after THA compared to the proximal-engaging cementless stem, although the shapes of the stems matched. The TNS stem could reduce SS, stem loosening, and periprosthetic fractures. Trial registration: Current Controlled Trials. ISRCTN21241251. https://www.isrctn.com/search?q=21241251. The date of registration was October 26, 2021. Retrospectively registered.

  8. PJI 人工関節周囲感染診断におけるalpha-defensin検査の有用性について

    森 優, 千葉 大介, 上村 雅之, 金淵 龍一, 馬場 一慈, 相澤 俊峰

    日本骨・関節感染症学会プログラム・抄録集　46回　108-108　2023/06

    Publisher: (一社)日本骨・関節感染症学会

  9. Low Young's Modulus TiNbSn Alloy Locking Plates Accelerate Osteosynthesis in Rabbit Tibiae

    Masashi Koguchi, Yu Mori, Masayuki Kamimura, Kentaro Ito, Hidetatsu Tanaka, Hiroaki Kurishima, Tomoki Koyama, Naoko Mori, Naoya Masahashi, Toshimi Aizawa

    The Tohoku Journal of Experimental Medicine　2023

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.2023.j075 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  10. Two-stage revision knee arthroplasty for metallosis in a patient with rheumatoid arthritis: A case report

    Tomoki Koyama, Yu Mori, Masayuki Kamimura, Takashi Aki, Takuya Izumiyama, Naoko Mori, Daisuke Chiba, Ko Hashimoto, Nobuyuki Yamamoto, Toshimi Aizawa

    SAGE Open Medical Case Reports　2023/01

    DOI： 10.1177/2050313X231177752 　

  11. A modified minimally invasive surgery for thoracic pyogenic spondylitis: Percutaneous pedicle screw fixation in combination with a vertebral debridement in a separate posterolateral approach—A case report

    Yuki Sato, Ko Hashimoto, Michiharu Matsuda, Takahiro Onoki, Masayuki Kamimura, Kohei Takahashi, Yoshito Onoda, Daisuke Chiba, Yu Mori, Haruo Kanno, Nobuyuki Yamamoto, Toshimi Aizawa

    Clinical Case Reports　10　(12)　2022/12

    Publisher: Wiley

    DOI： 10.1002/ccr3.6710 　

    ISSN： 2050-0904

    eISSN： 2050-0904

  12. How much force is acting on the shoulder joint to create a Hill-Sachs Lesion or reverse Hill-Sachs Lesion?

    Toshimitsu Etoh, Nobuyuki Yamamoto, Jun Kawakami, Masayuki Kamimura, Daisuke Chiba, Yu Mori, Ko Hashimoto, Toshimi Aizawa, Eiji Itoi

    Journal of Orthopaedic Science　2022/10

    Publisher: Elsevier BV

    DOI： 10.1016/j.jos.2022.09.016 　

    ISSN： 0949-2658

  13. β-type TiNbSn Alloy Plates with Low Young Modulus Accelerates Osteosynthesis in Rabbit Tibiae

    Kentaro Ito, Yu Mori, Masayuki Kamimura, Masashi Koguchi, Hiroaki Kurishima, Tomoki Koyama, Naoko Mori, Naoya Masahashi, Shuji Hanada, Eiji Itoi, Toshimi Aizawa

    Clinical Orthopaedics and Related Research　480　(9)　1817-1832　2022/09/01

    DOI： 10.1097/CORR.0000000000002240 　

    ISSN： 0009-921X

    eISSN： 1528-1132

  14. 外反型変形性膝関節症に対する遠位大腿骨骨切り術3例4膝の治療成績

    有野 敦司, 秋 貴史, 上村 雅之, 伊東 健太郎, 阿部 高久, 古口 昌志, 佐藤 宏陽, 藤盛 理子, 相澤 俊峰

    東北膝関節研究会会誌　30　27-31　2022/07

    Publisher: 東北膝関節研究会

    ISSN： 0917-5164

    eISSN： 2433-5614

  15. 「若年に見られる膝外傷後変形性膝関節症のマネジメント」 ACL再建術後に生じるOA変化の実態 KOACADを用いた定量評価

    秋 貴史, 上村 雅之, 伊東 健太郎, 阿部 高久, 古口 昌志, 佐藤 宏陽, 藤盛 理子, 井樋 栄二, 相澤 俊峰, 曽木 靖仁

    東北整形災害外科学会雑誌　65　(1)　173-174　2022/06

    Publisher: 東北整形災害外科学会

    ISSN： 1348-8694

  16. メタローシスに対して二期的に人工膝関節再置換術を行った関節リウマチの一例

    古山 和樹, 森 優, 上村 雅之, 相澤 俊峰

    日本リウマチ学会北海道・東北支部学術集会抄録集　31回　56-56　2022/01

    Publisher: (一社)日本リウマチ学会-北海道・東北支部

  17. Evaluation of the usefulness of the Synovasure alpha-defensin lateral flow test kit for the diagnosis of periprosthetic joint infection in Japanese patients

    Yu Mori, Ryuichi Kanabuchi, Kazayoshi Baba, Daisuke Chiba, Masayuki Kamimura, Naoko Mori, Toshimi Aizawa

    Journal of Orthopaedic Science　27　(4)　935-938　2022

    DOI： 10.1016/j.jos.2022.05.001 　

    ISSN： 0949-2658

    eISSN： 1436-2023

  18. Effect of denosumab switched from bisphosphonates in preventing joint destruction in postmenopausal rheumatoid arthritis patients with anti-cyclic citrullinated peptide antibodies

    Yu Mori, Takuya Izumiyama, Hiroaki Kurishima, Masayuki Kamimura, Kazuyoshi Baba, Naoko Mori, Eiji Itoi

    Journal of Orthopaedic Surgery and Research　16　(1)　2021/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s13018-021-02271-2 　

    eISSN： 1749-799X

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    <title>Abstract</title><sec> <title>Introduction</title> This study aimed to determine the effects of denosumab treatment on the joint destruction of Japanese females with rheumatoid arthritis (RA) and anti-cyclic citrullinated peptide (CCP) antibodies. </sec><sec> <title>Materials and methods</title> This retrospective longitudinal study included 56 patients treated with denosumab and 50 patients treated with bisphosphonate. All participants were positive for anti-CCP antibodies. All patients also had a history of osteoporosis treatment with bisphosphonate, which was either continued or switched to 60 mg of subcutaneous denosumab injection every 6 months. To assess the progression of joint destruction, hand and foot radiographs were taken, and changes in modified total Sharp score (mTSS), erosion score (ERO), and joint space narrowing score (JSN) were evaluated at 12 months and 24 months. The changes in BMD of the lumbar spine and hip were also assessed at 12 months. </sec><sec> <title>Results</title> At 12 months, there were significant differences in the change of ERO (<italic>p</italic> = 0.015) and mTSS (<italic>p</italic> = 0.01). Similarly, there were significant differences in the change of ERO (<italic>p</italic> = 0.013) and mTSS (<italic>p</italic> = 0.003) at 24 months. In contrast, no significant difference was observed in the changes of JSN and clinical parameters. There were significant differences in the changes in BMD in the femoral neck (<italic>p</italic> = 0.011) and total hip (<italic>p</italic> = 0.012). </sec><sec> <title>Conclusion</title> Denosumab treatment might be effective for the inhibition of bone erosion progression in the patients with RA, and it potentially contributes to the treatment of osteoporosis and prevention of destructive arthritis in patients with switching treatment from bisphosphonate<bold>.</bold> </sec>

  19. A Right Angle Guide for Distal Tuberosity Osteotomy With Medial Open Wedge High Tibial Osteotomy for Varus Knee Osteoarthritis. International-journal

    Akira Sasaki, Takehiko Sugita, Nobuyuki Itaya, Toshimi Aizawa, Naohisa Miyatake, Seiya Miyamoto, Ikuo Maeda, Masayuki Kamimura, Atsushi Takahashi, Hideaki Nagamoto

    Arthroscopy techniques　10　(4)　e1007-e1016　2021/04

    DOI： 10.1016/j.eats.2020.11.017 　

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    Medial open wedge high tibial osteotomy (OWHTO) is usually performed with proximal tuberosity osteotomy or setting the osteotomy line proximal to the tuberosity. However, OWHTO can result in patellofemoral complications due to postoperative patella infera. A new OWHTO technique, biplanar osteotomy with a distal tuberosity osteotomy, was reported in 2004 to prevent postoperative patella infera. To ensure that the 2 osteotomy lines maintain perpendicular, we describe the OWHTO procedure with a distal tuberosity osteotomy technique using a TriS Medial HTO Plate System (Olympus Terumo Biomaterials Corp., Tokyo, Japan) and a right angle guide we developed. In this Technical Note, we describe the procedure and advantages, risks, and limitations, as well as the pearls and pitfalls based on our experience.

  20. Acceleration of fracture healing in mouse tibiae using intramedullary nails composed of β-type tinbsn alloy with low young’s modulus

    Yu Mori, Hirokazu Fujisawa, Masayuki Kamimura, Atsushi Kogure, Hidetatsu Tanaka, Naoko Mori, Naoya Masahashi, Toshimi Aizawa

    Tohoku Journal of Experimental Medicine　255　(2)　135-142　2021

    DOI： 10.1620/tjem.255.135 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  21. Obesity is a risk factor for osteoarthritis progression and spontaneous osteoporosis is a risk for the development of spontaneous osteonecrosis in patients with medial meniscus posterior root tear.

    Atsushi Takahashi, Jutaro Umehara, Masayuki Kamimura, Toshimi Aizawa, Eiji Itoi

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　2020/10/05

    DOI： 10.1016/j.jos.2020.09.001 　

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    BACKGROUND: Obesity is a representative risk factor for osteoarthritis (OA). The relationship between osteoporosis and executed osteonecrosis has been reported. The primary aim of this study was to determine the influence of obesity and osteoporosis on disease progression in patients with medial meniscus posterior root tear (MMPRT). METHODS: We included 41 knees with MMPRT in this study. MMPRT was diagnosed based on the presence of both a meniscus ghost sign and a vertical linear defect on MRI. OA progression and development of osteonecrosis were evaluated using plain radiographs obtained at the initial visit and the final follow-up. The follow-up period for all knees was 30 ± 8 (mean ± standard deviation) months. Patients' physical attributes were assessed at initial visits; these attributes included body mass index (BMI) and the clinical risk for osteoporotic fracture, as determined by the World Health Organization fracture risk assessment tool (FRAX). Patients with a BMI ≥25 kg/m2 were classified in the obesity group and those with a BMI <25 kg/m2 in the control group. Patients with a FRAX score of ≥10% were classified in the high FRAX group and those with a FRAX score of <10% in the low FRAX group. RESULTS: OA progression evaluated by Kellgren-Lawrence grading scale was observed in 75% patients in the obesity group (1 grade in 38%, 2 grades in 31%, and 3 grades in 6%) and 58% in the control group (1 grade in 58%). Patients in the obesity group showed significantly greater OA progression. Spontaneous osteonecrosis was observed in no knees at the initial visit and six knees at the final follow-up. All six lesions were observed in the high FRAX group, which was statistically significant. CONCLUSIONS: OA progression and development of osteonecrosis were the two representative deterioration patterns in patients with MMPRT. High BMI was related with OA progression, and FRAX score of ≥10% with the development of osteonecrosis.

  22. Improved Osseointegration of a TiNbSn Alloy with a Low Young’s Modulus Treated with Anodic Oxidation Peer-reviewed

    Tomonori Kunii, Yu Mori, Hidetatsu Tanaka, Atsushi Kogure, Masayuki Kamimura, Naoko Mori, Shuji Hanada, Naoya Masahashi, Eiji Itoi

    Scientific Reports　9　(1)　13985　2019/12/01

    DOI： 10.1038/s41598-019-50581-7 　

    eISSN： 2045-2322

  23. Quality of life after staged bilateral total knee arthroplasty: a minimum five-year follow-up study of seventy-eight patients. International-journal Peer-reviewed

    Sugita T, Miyatake N, Aizawa T, Sasaki A, Kamimura M, Takahashi A

    International orthopaedics　43　(10)　2309-2314　2019/10

    DOI： 10.1007/s00264-018-4196-0 　

    ISSN： 0341-2695

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    PURPOSE: Although many studies have been performed to evaluate the quality of life (QOL) and patient satisfaction after total knee arthroplasty (TKA), almost all evaluations were performed in patients after unilateral TKA or in patients after mixed unilateral and bilateral TKA. Accordingly, this study aimed to evaluate QOL after staged bilateral TKA. METHODS: A total of 78 patients who underwent staged bilateral TKA for varus knee osteoarthritis were included in this study. All patients had longitudinal follow-up evaluations for at least five years. QOL was assessed by the Japanese Knee Osteoarthritis Measure (JKOM), a disease-specific and patient-derived QOL measure for Japanese patients. Conventional objective outcome scales, including the Knee Society Score and the Timed Up and Go test, were also assessed. In addition, QOL and objective outcomes were compared between the younger (≤ 80 years, average 75.8 years) and older (> 80 years, average 84.7 years) age groups at the final follow-up. RESULTS: Improvements in both JKOM and objective outcomes reached a plateau one year after staged bilateral TKA. Improvements were prolonged for more than five years. There were no statistically significant differences in JKOM or objective outcomes between the younger and older age groups, despite an 8.9-year difference in the average age. CONCLUSIONS: This was the first longitudinal study to evaluate QOL and objective outcomes after staged bilateral TKA for a period of at least five years. Improvements in QOL and objective outcomes reached a plateau one year after staged bilateral TKA and were prolonged for more than five years. No significant differences were observed in outcome scores between the younger and older age groups.

  24. Meniscal tear morphology independently affects pain relief following arthroscopic partial meniscectomy in middle-aged patients Peer-reviewed

    Masayuki Kamimura, Jutaro Umehara, Atsushi Takahashi, Yu Mori, Daisuke Chiba, Yoshiyuki Kuwahara, Eiji Itoi

    Knee Surgery, Sports Traumatology, Arthroscopy　27　(8)　2460-2467　2019/08/01

    DOI： 10.1007/s00167-018-5238-2 　

    ISSN： 0942-2056

    eISSN： 1433-7347

  25. 開大型高位脛骨骨切り術と開大型粗面下骨切り術の術後膝蓋骨高変化

    高橋 敦, 上村 雅之, 小笠原 将教, 國井 知典, 曽木 靖仁, 井樋 栄二, 佐々木 啓, 杉田 健彦

    JOSKAS　44　(4)　241-241　2019/05

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

  26. 人工膝関節全置換術後における床からの立ち上がり動作の解析

    上村 雅之, 高橋 敦, 小笠原 将教, 國井 知典, 曽木 靖仁, 井樋 栄二

    JOSKAS　44　(4)　626-626　2019/05

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

  27. Journey2 BCS(Bi-Cruciate Stabilizing TKA)とLegion PSにおけるTKA術前後でのCT fusion画像を用いた関節面位置変化の比較検討

    曽木 靖仁, 高橋 敦, 上村 雅之, 小笠原 将教, 國井 知典, 井樋 栄二

    JOSKAS　44　(4)　629-629　2019/05

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

  28. Effects of elastic intramedullary nails composed of low Young's modulus Ti-Nb-Sn alloy on healing of tibial osteotomies in rabbits Peer-reviewed

    Atsushi Kogure, Yu Mori, Hidetatsu Tanaka, Masayuki Kamimura, Naoya Masahashi, Shuji Hanada, Eiji Itoi

    Journal of Biomedical Materials Research - Part B Applied Biomaterials　107　(3)　700-707　2019/04

    DOI： 10.1002/jbm.b.34163 　

    ISSN： 1552-4973

    eISSN： 1552-4981

  29. Effects of intramedullary nails composed of a new β-type Ti-Nb-Sn alloy with low Young's modulus on fracture healing in mouse tibiae Peer-reviewed

    Hirokazu Fujisawa, Yu Mori, Atsushi Kogure, Hidetatsu Tanaka, Masayuki Kamimura, Naoya Masahashi, Shuji Hanada, Eiji Itoi

    Journal of Biomedical Materials Research - Part B Applied Biomaterials　106　(8)　2841-2848　2018/11

    DOI： 10.1002/jbm.b.34064 　

    ISSN： 1552-4973

    eISSN： 1552-4981

  30. The effect of morphine added to periarticular multimodal drug injection or spinal anesthesia on pain management and functional recovery after total knee arthroplasty. Peer-reviewed

    Miyamoto S, Sugita T, Aizawa T, Miyatake N, Sasaki A, Maeda I, Kamimura M, Takahashi A

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　23　(5)　801-806　2018/09

    DOI： 10.1016/j.jos.2018.04.013 　

    ISSN： 0949-2658

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    BACKGROUND: The efficacy of morphine added to periarticular multimodal drug injection (PMDI) for pain management after total knee arthroplasty (TKA) is controversial. Adding morphine to spinal anesthesia has reportedly improved pain relief for the first 24 h. We examined the effect of morphine added to PMDI or spinal anesthesia on pain management and functional recovery after TKA. METHODS: A total of 97 patients were randomized into three groups: in Group A (34 patients), 10 mg morphine was added to PMDI; Group B (31 patients), 0.1 mg morphine was added to spinal anesthesia; and Group C (32 patients), morphine was added to neither the PMDI nor spinal anesthetic. To evaluate the efficacy of added morphine for pain management, we assessed rest pain, the number of times analgesics were used, and the time period until the first analgesic use. The adverse effects of morphine were assessed by counting the numbers of times vomiting occurred and antiemetics were used. Functional recovery was evaluated by recording the range of motion of the knee and the date of ability to walk. RESULTS: Rest pain was the least in Group B at 6 and 12 h after operation. The number of times analgesics were used was the least in Group B. The time period until the first analgesic use was the longest in Group B. The number of vomiting episodes was the least in Group C. The number of times antiemetics were used was higher in Group A than in Group C. There were no significant differences in the range of motion and date of ability to walk among the three groups. CONCLUSIONS: The efficacy of morphine added to PMDI was limited, and that of morphine added to spinal anesthesia disappeared within 20 h postoperatively. Adding morphine to PMDI or spinal anesthesia did not improve functional recovery and caused some adverse effects.

  31. 人工膝関節全置換術および人工股関節全置換術後の床からの立ち上がり動作の解析

    沼倉 裕堅, 上村 雅之, 高橋 敦, 田中 秀達, 馬場 一慈, 井樋 栄二

    東北整形災害外科学会雑誌　61　(1)　156-156　2018/06

    Publisher: 東北整形災害外科学会

    ISSN： 1348-8694

  32. ACL損傷膝に生じる変化 3D MRIによる検討

    高橋 敦, 上村 雅之, 國井 知典, 秋 貴史, 柏葉 光宏, 小笠原 将教, 曽木 靖仁, 井樋 栄二

    JOSKAS　43　(4)　326-326　2018/05

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

  33. Femoral footprint of the popliteus tendon may be at the risk of damage during total knee arthroplasty Peer-reviewed

    Takashi Aki, Takehiko Sugita, Atsushi Takahashi, Toshimi Aizawa, Masayuki Kamimura, Akira Sasaki, Naohisa Miyatake, Eiji Itoi

    KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY　25　(12)　3718-3722　2017/12

    DOI： 10.1007/s00167-016-4177-z 　

    ISSN： 0942-2056

    eISSN： 1433-7347

  34. 術前に伸展制限を有した膝に対するUKAの術後成績

    曽木 靖仁, 高橋 敦, 上村 雅之, 井樋 栄二

    JOSKAS　42　(4)　812-812　2017/05

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

  35. Preliminary results of managing large medial tibial defects in primary total knee arthroplasty: autogenous morcellised bone graft Peer-reviewed

    Takehiko Sugita, Toshimi Aizawa, Naohisa Miyatake, Akira Sasaki, Masayuki Kamimura, Atsushi Takahashi

    INTERNATIONAL ORTHOPAEDICS　41　(5)　931-937　2017/05

    DOI： 10.1007/s00264-016-3339-4 　

    ISSN： 0341-2695

    eISSN： 1432-5195

  36. Evaluation of the size and position of the insertion of the anterior medial meniscus root in varus osteoarthritic knees Peer-reviewed

    Akira Sasaki, Takehiko Sugita, Toshimi Aizawa, Naohisa Miyatake, Masayuki Kamimura, Hirokazu Fujisawa, Atsushi Takahashi

    KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY　25　(2)　362-367　2017/02

    DOI： 10.1007/s00167-015-3963-3 　

    ISSN： 0942-2056

    eISSN： 1433-7347

  37. Bone mineral density of postmenopausal women with rheumatoid arthritis depends on disease duration regardless of treatment Peer-reviewed

    Yu Mori, Yoshiyuki Kuwahara, Shinpei Chiba, Atsushi Kogre, Kazuyoshi Baba, Masayuki Kamimura, Eiji Itoi

    Journal of Bone and Mineral Metabolism　35　(1)　52-57　2017/01/01

    DOI： 10.1007/s00774-015-0716-9 　

    ISSN： 0914-8779

    eISSN： 1435-5604

  38. Identification of a progenitor cell population destined to form fracture fibrocartilage callus in Dickkopf-related protein 3–green fluorescent protein reporter mice Peer-reviewed

    Yu Mori, Douglas Adams, Yusuke Hagiwara, Ryu Yoshida, Masayuki Kamimura, Eiji Itoi, David W. Rowe

    Journal of Bone and Mineral Metabolism　34　(6)　606-614　2016/11/01

    DOI： 10.1007/s00774-015-0711-1 　

    ISSN： 0914-8779

    eISSN： 1435-5604

  39. Comparison of intraoperative anthropometric measurements of the proximal tibia and tibial component in total knee arthroplasty Peer-reviewed

    Naohisa Miyatake, Takehiko Sugita, Toshimi Aizawa, Akira Sasaki, Ikuo Maeda, Masayuki Kamimura, Hirokazu Fujisawa, Atsushi Takahashi

    JOURNAL OF ORTHOPAEDIC SCIENCE　21　(5)　635-639　2016/09

    DOI： 10.1016/j.jos.2016.06.003 　

    ISSN： 0949-2658

    eISSN： 1436-2023

  40. Apatite formation and biocompatibility of a low young's modulus Ti-Nb-Sn alloy treated with anodic oxidation and hot water Peer-reviewed

    Hidetatsu Tanaka, Yu Mori, Atsushi Noro, Atsushi Kogure, Masayuki Kamimura, Norikazu Yamada, Shuji Hanada, Naoya Masahashi, Eiji Itoi

    PLoS ONE　11　(2)　e0150081　2016/02

    DOI： 10.1371/journal.pone.0150081 　

    eISSN： 1932-6203

  41. Potential risk of excising the femoral insertion of the popliteus tendon during primary total knee arthroplasty: a biometric study Peer-reviewed

    Atsushi Takahashi, Takehiko Sugita, Toshimi Aizawa, Daisuke Chiba, Masayuki Kamimura, Takashi Aki, Eiji Itoi

    JOURNAL OF ORTHOPAEDIC SCIENCE　20　(6)　1030-1035　2015/11

    DOI： 10.1007/s00776-015-0773-x 　

    ISSN： 0949-2658

    eISSN： 1436-2023

  42. 広範な大腿骨骨欠損を伴うTKAゆるみに対し腫瘍用TKAを用いて再々置換を行った1例 Peer-reviewed

    上村 雅之, 高橋, 敦, 柏葉, 光宏, 藤澤, 博一, 井樋 栄二

    JOSKAS　40　(4)　500-500　2015/06

  43. Impaired fracture healing caused by deficiency of the immunoreceptor adaptor protein DAP12 Peer-reviewed

    Masayuki Kamimura, Yu Mori, Akiko Sugahara-Tobinai, Toshiyuki Takai, Eiji Itoi

    PLoS ONE　10　(6)　e0128210　2015/06/01

    DOI： 10.1371/journal.pone.0128210 　

    eISSN： 1932-6203

  44. TKA術後屈曲拘縮の危険因子 Peer-reviewed

    板谷 信行, 高橋, 敦, 杉田, 健彦, 井樋, 栄二, 上村 雅之

    日本整形外科学会雑誌　89　(3)　S708-S708　2015/03

  45. Medial meniscus tear morphology and related clinical symptoms in patients with medial knee osteoarthritis Peer-reviewed

    Masayuki Kamimura, Jutaro Umehara, Atsushi Takahashi, Toshimi Aizawa, Eiji Itoi

    KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY　23　(1)　158-163　2015/01

    DOI： 10.1007/s00167-014-2939-z 　

    ISSN： 0942-2056

    eISSN： 1433-7347

  46. Secondary subacromial impingement after valgus closing-wedge osteotomy for proximal humerus varus. Peer-reviewed

    Sano H, Kamimura M, Oizumi A, Isefuku S

    Case reports in orthopedics　2015　652096　2015

    DOI： 10.1155/2015/652096 　

    ISSN： 2090-6749

  47. Autologous morselised bone grafting for medial tibial defects in total knee arthroplasty Peer-reviewed

    Takehiko Sugita, Toshimi Aizawa, Akira Sasaki, Naohisa Miyatake, Hirokazu Fujisawa, Masayuki Kamimura

    JOURNAL OF ORTHOPAEDIC SURGERY　23　(2)　185-189　2015

    DOI： 10.1177/230949901502300214 　

    ISSN： 1022-5536

    eISSN： 2309-4990

  48. 圧潰を呈した大腿骨外側顆部骨嚢胞に対し大腿骨遠位内反骨切り術を行った1例 Peer-reviewed

    上村 雅之, 柏葉, 光宏, 高橋, 敦, 藤澤, 博一, 井樋 栄二

    東北膝関節研究会会誌　23　9-12　2014/07

  49. Radiolucent zone of the patella following total knee arthroplasty without patellar resurfacing Peer-reviewed

    Atsushi Takahashi, Masayuki Kamimura, Hirotaka Sano, Mitsuhiro Kashiwaba, Masahiro Ohnuma, Eiji Itoi

    JOURNAL OF ORTHOPAEDIC SCIENCE　19　(4)　558-563　2014/07

    DOI： 10.1007/s00776-014-0570-y 　

    ISSN： 0949-2658

    eISSN： 1436-2023

  50. Effect of medial tibial torsion on the sagittal alignment of lower legs in patients with medial knee osteoarthritis Peer-reviewed

    Atsushi Takahashi, Toshimi Aizawa, Takashi Aki, Mitsuhiro Kashiwaba, Masayuki Kamimura, Shin Hitachi, Eiji Itoi

    Surgical and Radiologic Anatomy　35　(3)　205-210　2013/04

    DOI： 10.1007/s00276-012-1011-2 　

    ISSN： 0930-1038 1279-8517

  51. Patellar morphology and femoral component geometry influence patellofemoral contact stress in total knee arthroplasty without patellar resurfacing Peer-reviewed

    Atsushi Takahashi, Hirotaka Sano, Masahiro Ohnuma, Mitsuhiro Kashiwaba, Daisuke Chiba, Masayuki Kamimura, Takehiko Sugita, Eiji Itoi

    KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY　20　(9)　1787-1795　2012/09

    DOI： 10.1007/s00167-011-1768-6 　

    ISSN： 0942-2056

  52. 膝蓋骨非置換TKAにおける術後膝蓋骨透亮像 Peer-reviewed

    上村 雅之, 高橋 敦, 佐野 博高, 大沼 正宏, 柏葉 光宏, 井樋 栄二

    東北整形災害外科学会雑誌　55　(1)　63-67　2011/06

  53. 膝蓋骨形状は膝蓋骨非置換TKAの膝蓋大腿関節応力に影響する 定量的CTを用いた三次元有限要素法による解析 Peer-reviewed

    高橋敦, 佐野博高, 千葉大介, 柏葉光宏, 八田卓久, 上村雅之, 大沼正宏, 井樋栄二

    日本整形外科学会雑誌　84　(8)　S1200-S1200　2010/08

  54. 膝蓋骨非置換TKAにおける術後関節症性変化の機種による差異 Peer-reviewed

    上村雅之, 高橋敦, 柏葉光宏, 大沼正宏, 井樋栄二

    JOSKAS　35　(1)　26-27　2010/03

  55. 膝蓋骨非置換TKAにおける膝蓋骨内応力シミュレーション 機種による差異と臨床との比較 Peer-reviewed

    高橋敦, 大沼正宏, 柏葉光宏, 佐野博高, 上村雅之, 井樋栄二

    JOSKAS　35　(1)　24-25　2010/03

Show all ︎Show first 5

Misc. 35

  1. Surgical Approach to Pigmented Villonodular Synovitis and Synovial Osteochondromatosis in Pathological Expansion of the Popliteus Bursa. International-journal Peer-reviewed

    Takehiko Sugita, Nobuyuki Itaya, Toshimi Aizawa, Masayuki Kamimura, Atsushi Takahashi, Naohisa Miyatake

    Arthroscopy techniques　8　(12)　e1495-e1499　2019/12

    DOI： 10.1016/j.eats.2019.07.028 　

  2. 当院初診患者における若年性変形性膝関節症の実態

    曽木 靖仁, 高橋 敦, 上村 雅之, 秋 貴史, 板谷 信行, 小笠原 将教, 國井 知典, 井樋 栄二

    東北膝関節研究会会誌　27　29-32　2018/07

    Publisher: 東北膝関節研究会

    ISSN： 0917-5164

    eISSN： 2433-5614

  3. 膝前十字靱帯再建術後の関節症変化

    小笠原 将教, 高橋 敦, 上村 雅之, 秋 貴史, 國井 知典, 板谷 信行, 曽木 靖仁, 井樋 栄二

    東北膝関節研究会会誌　27　33-37　2018/07

    Publisher: 東北膝関節研究会

    ISSN： 0917-5164

    eISSN： 2433-5614

  4. ACL損傷膝における前外側構成体の損傷頻度3D‐MRI

    國井知典, 高橋敦, 柏葉光宏, 上村雅之, 猪川訓志, 秋貴史, 板谷信行, 小笠原将教, 伊東健太郎

    JOSKAS　43　(4)　503-503　2018/05

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

  5. ACL損傷膝における前外側構成体の損傷頻度3D-MRI

    國井 知典, 高橋 敦, 柏葉 光宏, 上村 雅之, 猪川 訓志, 秋 貴史, 板谷 信行, 小笠原 将教, 伊東 健太郎

    JOSKAS　43　(4)　503-503　2018/05

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

  6. KOACADにより評価したACL再建術後の内側関節裂隙狭小化と関連する因子の検討

    曽木靖仁, 高橋敦, 上村雅之, 秋貴史, 板谷信行, 小笠原将教, 國井知典, 井樋栄二

    JOSKAS　43　(4)　684-684　2018/05

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

  7. KOACADにより評価したACL再建術後の内側関節裂隙狭小化と関連する因子の検討

    曽木 靖仁, 高橋 敦, 上村 雅之, 秋 貴史, 板谷 信行, 小笠原 将教, 國井 知典, 井樋 栄二

    JOSKAS　43　(4)　684-684　2018/05

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

  8. 膝前十字靱帯再建術後の関節症変化

    小笠原将教, 高橋敦, 上村雅之, 秋貴史, 國井知典, 板谷信行, 曽木靖仁, 井樋栄二

    東北膝関節研究会会誌　27　(0)　33-37　2018

    Publisher: 東北膝関節研究会

    DOI： 10.24633/tohokuhiza.27.0_33 　

    ISSN： 0917-5164

  9. 当院初診患者における若年性変形性膝関節症の実態

    曽木靖仁, 高橋敦, 上村雅之, 秋貴史, 板谷信行, 小笠原将教, 國井知典, 井樋栄二

    東北膝関節研究会会誌　27　(0)　29-32　2018

    Publisher: 東北膝関節研究会

    DOI： 10.24633/tohokuhiza.27.0_29 　

    ISSN： 0917-5164

  10. ACL再建術の長期成績と二次性関節症 ACL再建術後の関節症性変化

    高橋 敦, 小笠原 将教, 上村 雅之, 秋 貴史, 板谷 信行, 國井 知典, 井樋 栄二

    日本関節病学会誌　36　(3)　339-339　2017/10

    Publisher: (一社)日本関節病学会

    ISSN： 1883-2873

  11. 診断・治療に難渋した膝症例 外傷後の脛骨内反変形と変形性膝関節症により高度内反膝を呈した1例

    秋 貴史, 高橋 敦, 上村 雅之, 藤澤 博一, 板谷 信行, 國井 知典, 井樋 栄二

    東北整形災害外科学会雑誌　60　(1)　187-187　2017/06

    Publisher: 東北整形災害外科学会

    ISSN： 1348-8694

  12. 日本人早期膝OAの前向き実態調査

    高橋 敦, 上村 雅之, 秋 貴史, 板谷 信行, 小笠原 将教, 國井 知典, 井樋 栄二

    JOSKAS　42　(4)　455-455　2017/05

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

  13. TKA設置精度の変遷から分かったこと 8年間の3D-CTによる設置精度評価

    高橋 敦, 上村 雅之, 秋 貴史, 板谷 信行, 小笠原 将教, 國井 知典, 井樋 栄二

    JOSKAS　42　(4)　655-655　2017/05

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

  14. Open wedge HTOの回旋アライメント変化 CT fusion画像による解析

    秋 貴史, 高橋 敦, 上村 雅之, 藤澤 博一, 板谷 信行, 小笠原 将教, 國井 知典, 柏葉 光宏, 井樋 栄二

    JOSKAS　42　(4)　320-320　2017/05

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

  15. ACL再断裂症例の脛骨後傾

    阿部 高久, 高橋 敦, 上村 雅之, 秋 貴史, 板谷 信行, 小笠原 将教, 井樋 栄二

    JOSKAS　42　(4)　640-640　2017/05

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

  16. 人工膝関節全置換術後における床からの立ち上がり動作および所要時間の解析

    上村 雅之, 高橋 敦, 秋 貴史, 板谷 信行, 井樋 栄二

    JOSKAS　42　(4)　653-653　2017/05

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

  17. ACL損傷膝における前外側構成体の損傷頻度 3D-MRIを用いて

    國井 知典, 高橋 敦, 柏葉 光宏, 伊東 健太郎, 猪川 訓志, 秋 貴史, 上村 雅之, 板谷 信行, 小笠原 将教, 井樋 栄二

    JOSKAS　42　(4)　706-706　2017/05

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

  18. TKA設置精度の変遷から分かったこと 8年間の3D-CTによる設置精度評価

    高橋 敦, 上村 雅之, 藤澤 博一, 秋 貴史, 板谷 信行, 井樋 栄二, 大沼 正宏, 柏葉 光宏

    日本整形外科学会雑誌　91　(3)　S1019-S1019　2017/03

    Publisher: (公社)日本整形外科学会

    ISSN： 0021-5325

  19. 人工膝関節全置換術後の床からの立ち上がり動作の解析

    上村 雅之, 高橋 敦, 藤澤 博一, 板谷 信行, 秋 貴史, 井樋 栄二

    日本整形外科学会雑誌　91　(3)　S1006-S1006　2017/03

    Publisher: (公社)日本整形外科学会

    ISSN： 0021-5325

  20. TKAインプラント回旋設置とfemorotibial mismatchの関係

    秋 貴史, 高橋 敦, 上村 雅之, 藤澤 博一, 板谷 信行, 國井 知典, 井樋 栄二

    日本整形外科学会雑誌　91　(3)　S1018-S1018　2017/03

    Publisher: (公社)日本整形外科学会

    ISSN： 0021-5325

  21. 中高年の膝痛は画像に写るか?

    高橋 敦, 上村 雅之, 藤澤 博一, 秋 貴史, 板谷 信行, 國井 知典, 井樋 栄二

    JOSKAS　41　(4)　357-357　2016/07

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

  22. Bioactivity of Surface Modified TiNbSn Alloy for Biomedical Implant

    64　(3)　216-221　2016/07

    Publisher: 日本チタン協会

    ISSN： 1341-1713

  23. 人工膝関節全置換術後における床からの立ち上がり動作の解析

    上村 雅之, 高橋 敦, 藤澤 博一, 板谷 信行, 秋 貴史, 井樋 栄二

    JOSKAS　41　(4)　285-285　2016/07

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

  24. TKAインプラント回旋設置とfemorotibial mismatchの関係

    秋 貴史, 高橋 敦, 上村 雅之, 藤澤 博一, 板谷 信行, 柏葉 光宏, 國井 知典, 井樋 栄二

    JOSKAS　41　(4)　404-404　2016/07

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

  25. 外傷後の脛骨内反変形と変形性膝関節症により高度内反膝を呈した1例

    秋貴史, 高橋敦, 上村雅之, 藤澤博一, 板谷信行, 國井知典, 井樋栄二

    東北整形災害外科学会プログラム・抄録集　113th　43　2016

  26. 表面改質を施したインプラント用TiNbSn合金の生体活性

    正橋直哉, 森 優, 田中秀達, 小暮敦史, 野呂篤司, 上村雅之, 山田則一, 井樋栄二, 花田修治

    チタン　64　(3)　50-55　2016

  27. Posterior root tear of the medial meniscus

    58　(13)　1703-1711　2015/12

    Publisher: 金原出版

    ISSN： 0387-4095

  28. 内側半月板後角損傷後SONK発生とOA進行に関する前向き調査

    高橋 敦, 梅原 寿太郎, 上村 雅之, 藤澤 博一, 秋 貴史, 板谷 信行, 魚住 弘明, 井樋 栄二

    JOSKAS　40　(4)　558-558　2015/06

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

  29. 大腿骨形状がTKA設置に与える影響―大腿骨形状を考慮した術前計画の有用性―

    高橋敦, 柏葉光宏, 藤澤博一, 上村雅之, 秋貴史, 板谷信行, 井樋栄二

    日本人工関節学会プログラム・抄録集　45th　327　2015

  30. TKA術後屈曲拘縮の危険因子の検討

    板谷信行, 高橋敦, 上村雅之, 杉田健彦, 井樋栄二

    日本人工関節学会プログラム・抄録集　45th　403　2015

  31. 自家骨移植により骨欠損部を再建し人工膝関節置換術を行ったCharcot関節の1例

    佐々木 毅志, 杉田 健彦, 佐々木 啓, 前田 郁雄, 本間 哲夫, 大沼 正宏, 相沢 俊峰, 柏葉 光宏, 高橋 敦, 藤澤 博一, 上村 雅之

    東北整形災害外科学会雑誌　57　(1)　133-136　2014/06

    Publisher: 東北整形災害外科学会

    ISSN： 1348-8694

  32. Insertion of the anterior horn of the medial meniscus in varus osteoarthritis of the knee

    SUGITA Takehiko

    38　(2)　306-307　2013/04/25

    ISSN： 1884-8842

  33. 膝蓋骨非置換TKAにおいて膝蓋骨厚が術後可動域に与える影響

    板谷 信行, 高橋 敦, 上村 雅之, 杉田 健彦, 柏葉 光宏, 井樋 栄二

    JOSKAS　37　(4)　42-42　2012/06

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

  34. TKA術後femorotibial mismatchを最小化する脛骨回旋設置

    高橋 敦, 柏葉 光宏, 上村 雅之, 板谷 信行, 井樋 栄二

    JOSKAS　37　(4)　216-216　2012/06

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

  35. TKA PF関節の問題点 膝蓋骨形状は膝蓋骨非置換TKAの術後骨硬化像と応力に影響する

    高橋 敦, 佐野 博高, 大沼 正宏, 柏葉 光宏, 千葉 大介, 上村 雅之, 杉田 健彦, 井樋 栄二

    JOSKAS　35　(4)　116-116　2010/06

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

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Research Projects 3

  1. 生体親和性と抗菌性能を両立する低弾性率チタン合金材料の開発

    上村 雅之

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2024/04/01 - 2027/03/31

  2. 新規低弾性チタン合金であるTi-Nb-Sn合金を用いた骨折治療インプラントの開発

    上村 雅之

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 若手研究

    Institution: 東北大学

    2020/04/01 - 2023/03/31

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    市販のAOミニDCP 8穴プレート（Ti6Al4V合金製、ヤング率100.0GPa）と同型のプレートをTiNbSn合金（ヤング率49.1GPa）で作成し、日本白色家兎（オス）を用いた脛骨骨折モデルにおいて骨折治癒過程と骨強度の違いを評価した。 前年度は術後4週時点でのマイクロCTによる画像評価を行っており、術後8週時点での評価を追加した（各群6匹）。髄内仮骨の体積はTiNbSn合金群で有意に小さく、仮骨架橋幅を評価した結果、全体および髄内の架橋幅はTiNbSn合金群が有意に小さかった。TiNbSn合金群で先行した仮骨形成が成熟骨に置き換わった過程を示したと考えられる。 術後4週目時点でヘマトキシリン・エオジンとアルシアンブルーで染色した組織標本を作成し、組織形態計測を行った（各群6匹）。仮骨内に新たに形成された新生骨の定量的評価において、TiNbSn合金の新生骨形成量は仮骨全体および髄内仮骨において有意に大きかった。またTiNbSn合金群はプレート設置面側の骨切り部の新生骨形成量が有意に大きかった。仮骨内の残存軟骨組織の定量的評価において、両群間に有意な差はみられなかった。 次に、組織切片のオステオカルシン免疫化学染色を行い、仮骨全体、髄内および骨外におけるオステオカルシン陽性細胞数を定量的に評価した。TiNbSn合金ではオステオカルシン陽性細胞が有意に多かった。 以上の結果から、TiNbSn合金製プレートは術後早期の骨折治癒過程における髄内仮骨およびプレート設置面側の仮骨形成を促進し、骨強度の早期回復を誘導したと考えらえる。

  3. Development of the novel implant for fracture treatment using a TiNbSn alloy with a low Young's modulus

    Kamimura Masayuki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2017/04/01 - 2020/03/31

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    Titanium-niobium-tin (TiNbSn) alloy, which was developed by Tohoku University Institute for Material Research, has a low Young’s modulus close to that of human cortical bone. With the goal of developing the novel implant with TiNbSn alloy for fracture treatment, the effects of the elastic property of TiNbSn alloy implants on fracture healing were evaluated compared with conventional Ti-6Al-4V implants using a rabbit tibial osteotomy model. TiNbSn alloy nails showed significantly larger callus volume in micro-CT images and higher maximum load in mechanical testing. Next, TiNbSn alloy plates were prepared and their effects on fracture healing were evaluated using the same experimental animal model in histologic, radiographic and mechanical analyses.