Details of the Researcher

PHOTO

Ikuko Motoike
Section
Tohoku Medical Megabank Organization
Job title
Professor
Degree

Professional Memberships 2

  • 日本バイオインフォマティクス学会

  • 日本生物物理学会

Research Interests 5

  • Bioinformatics

  • 数理生物物理 非線形科学 反応拡散系

  • Reaction-diffusion computing

  • Nonlinear Science

  • Mathematical Biophysics

Research Areas 4

  • Life sciences / Biophysics /

  • Natural sciences / Bio-, chemical, and soft-matter physics /

  • Natural sciences / Mathematical physics and basic theory /

  • Life sciences / Genomics /

Papers 88

  1. Genome-Wide Meta-Analysis for High Myopia Provides Insights into Disease Mechanisms and Reveals a Causal Link to Primary Open-Angle Glaucoma. International-journal

    Kazuya Morino, Akira Meguro, Masao Nagasaki, Ikuko N Motoike, Masato Akiyama, Takahisa Kawaguchi, Shogo Numa, Yuki Mori, Shota Yasukura, Masahiro Akada, Shin-Ya Nakao, Takuro Kamei, Ai Nakata, Masaki Takeuchi, Norihiro Yamada, Yuki Mizuki, Takeshi Yoshida, Yukihide Momozawa, Yoichiro Kamatani, Hayato Anzawa, Yasuharu Tabara, Fumihiko Matsuda, Kengo Kinoshita, Kyoko Ohno-Matsui, Nobuo Fuse, Masayuki Yamamoto, Akitaka Tsujikawa, Nobuhisa Mizuki, Masahiro Miyake

    Ophthalmology science　6　(6)　101165-101165　2026/06

    DOI： 10.1016/j.xops.2026.101165 　

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    PURPOSE: To investigate the genetic architecture of high myopia. DESIGN: A meta-analysis of genome-wide association studies (meta-GWASs). PARTICIPANTS: A total of 7867 individuals with high myopic eyes and 21 700 controls were enrolled. METHODS: We performed a meta-GWAS comprising 3910 cases with high myopic eyes and 5718 controls in the discovery stage. A replication study included an independent set of 3957 participants with high myopic eyes and 15 982 control participants. Functional enrichment analysis was conducted using FUMA and ToppFun. We assessed shared genetic architectures between high myopia and 4 phenotypes (2 ocular diseases and 2 biometric features) using the LDSC software, followed by the evaluation of causality utilizing a bidirectional inverse variance-weighted Mendelian randomization (IVW-MR) analysis with sensitivity analyses. MAIN OUTCOME MEASURES: The association between single-nucleotide polymorphisms and high myopia. RESULTS: We identified 10 loci exceeding genome-wide significance (P < 5.0 × 10-8); 2 of those, rs2727196 in ADAMTS17 (odds ratio [OR] = 1.13, P = 2.91 × 10-8) and rs6564696 in MAFTRR (OR = 1.19, P = 1.78 × 10-10), were novel. Functional enrichment analysis revealed a significant role of 8 pathways in the pathogenesis of high myopia, including 2 pathways regarding acetylcholine-gated channels (gene ontology [GO]:0005892 and GO:0022848) and 4 pathways regarding Golgi body (GO:0033116, GO:0032580, GO:0030134, and GO:0031985). Genetic correlation analysis revealed shared polygenic architecture between high myopia and primary open-angle glaucoma (POAG) (r g [the measure of genetic correlation] = 0.41, P = 2.60 × 10-3). In the IVW-MR analysis, a causal relationship from high myopia to POAG was confirmed (OR = 1.14, P = 3.92 × 10-3), whereas an inverse causal relationship was not noticed (P = 0.97). CONCLUSIONS: Our study identified 2 novel high myopia-associated loci. Subsequent functional enrichment analysis offered important insights into the molecular biology of high myopia, demonstrating potential therapeutic targets. Previous studies could not definitively determine whether high myopia had a causal effect on POAG due to the potential influence of unmeasured confounders. By utilizing an MR method, which can control for even unmeasured confounders, this study provides data that support a causal association of high myopia on POAG. FINANCIAL DISCLOSURES: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

  2. Study Protocol and Characteristics of the Wearable Device Survey for Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study.

    Ippei Chiba, Naoki Nakaya, Shunji Mugikura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Sayuri Tokioka, Masato Takase, Tomohiro Nakamura, Satoshi Nagaie, Soichi Ogishima, Taku Obara, Ikuko N Motoike, Naoko Mori, Hisanori Matsui, Tatsuya Ando, Hideki Kobayashi, Taketoshi Ogawa, Shinji Tanaka, Nobuo Fuse, Fuji Nagami, Yoko Izumi, Shinichi Kuriyama, Atsushi Hozawa

    Journal of epidemiology　2026/05/02

    DOI： 10.2188/jea.JE20250540 　

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    Sleep and physical activity play a crucial role in brain and mental health. While traditional self-reported methods and research-grade accelerometers have several limitations, consumer-grade wearable devices, such as Fitbit, allow continuous, objective, and real-life data collection. The purpose of this article is to report the study protocol and participant characteristics of a wearable device survey that primarily aims to examine the relationship between brain health and long-term patterns of daily physical activity and sleep.Nearly 2,000 participants were recruited between September 2022 and December 2023, as part of the Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study, to wear Fitbit Charge 5 devices for 1 year, continuously tracking physical activity and sleep. Additionally, home blood pressure measurements and questionnaire data on housing conditions, psychological distress, and medication were collected every 4 months for a total of four assessments.The mean age of the participants was 58.5 years and 37.4% were men. For the first 30 days after the recruitment, mean step count was 8,910 steps/day, and a mean total sleep time was 370.4 min/night (approximately 6.2 h). The mean morning systolic blood pressure and diastolic blood pressure were 126.2 and 75.5 mmHg, respectively.This study provides a unique opportunity to integrate longitudinal consumer-grade wearable data, brain MRI, multiomics data, and comprehensive health records from existing cohorts to advance precision medicine and help prevent mental and neurodegenerative diseases, such as dementia. Limitations include potential selection bias, and a relatively smaller sample size than larger global studies.

  3. Relationship between age-related hearing loss and alcohol consumption in a Japanese population

    Hiyori Takahashi, Jun Suzuki, Ikuko N. Motoike, Miyuki Sakurai, Yuta Kobayashi, Gosuke Watarai, Hiroki Tozuka, Mana Kogure, Tetsuaki Kawase, Yohei Honkura, Ryoukichi Ikeda, Kengo Kinoshita, Naoki Nakaya, Taku Obara, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Fuse, Masayuki Yamamoto, Yukio Katori

    SCIENTIFIC REPORTS　16　(1)　2025/12/02

    DOI： 10.1038/s41598-025-29634-7 　

    ISSN： 2045-2322

  4. Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study. International-journal

    Masato Takase, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Kotaro Nochioka, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Seizo Koshiba, Kazuki Kumada, Ikuko Motoike, Eiji Hishinuma, Akira Narita, Taku Obara, Mami Ishikuro, Hisashi Ohseto, Ippei Takahashi, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Koichi Matsuda, Yoko Izumi, Kinuko Ohneda, Kengo Kinoshita, Atsushi Hozawa, Masayuki Yamamoto

    Cardiovascular diabetology　24　(1)　335-335　2025/08/14

    DOI： 10.1186/s12933-025-02849-8 　

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    BACKGROUND: No previous studies have explored metabolites associated with both genetic predispositions to type 2 diabetes (T2DM) and T2DM onset. Therefore, we aimed to explore metabolic profiles using genetic risk to identify pathways for tailored T2DM prevention strategies. METHODS: This prospective community-based cohort study in Japan included a total of 12,461 participants aged ≥ 20 years. Genetic predictors were genome-wide and pathway-based polygenic risk scores (PRSs). We quantified 43 metabolites using nuclear magnetic resonance spectroscopy. T2DM was defined as a non-fasting glucose level of ≥ 200 mg/dL, glycated hemoglobin level ≥ 6.5%, or self-reported T2DM treatment. A modified Poisson regression model was used to examine the associations of PRSs and metabolites with T2DM incidence. Linear associations were tested using the restricted cubic spline, and mediation analysis was conducted to assess the mediating effect of metabolites on the association between PRSs and T2DM incidence. RESULTS: During the 4.3-year median follow-up period, 354 T2DM cases were identified. A higher PRS was associated with incident T2DM (relative risk [RR] 2.09, 95% confidence interval [CI], 1.68-2.60, P < 0.001, 1-standard deviation [SD] increment). The nitrogen compound transport pathway PRS was associated with incident T2DM (RR 1.32, 95% CI 1.03-1.70, P < 0.001, 1-SD increment). Fourteen metabolites like glucose, 2-ketoisocaproic acid, glutamic acid, leucine, 2-aminobutyric acid, 2-hydroxybutyric acid, valine, 3-methyl-2-oxobutyric acid, alanine, 3-hydroxybutyric acid, 3-methyl-2-oxiovaleric acid, formic acid, arginine, and tyrosine were positively associated with the risk of T2DM. Only glycine was inversely associated with the risk of T2DM. Among 43 metabolites, 14 metabolites were positively associated with PRS (P for linear trend < 0.05). 3-hydroxyisobutyric-acid, 2-Aminobutyric acid, 2-ketoisocaproic acid, 2-hydroxybutyric acid, leucine, glycine, and glucose mediated the association between PRS and incident T2DM. CONCLUSIONS: Several metabolites were found to mediate the association between PRS and incident T2DM. These findings may contribute to a better understanding of the metabolic pathways involved in genetic susceptibility to T2DM.

  5. Gender differences in plasma element concentrations and associations between selenoprotein P and iron metabolism in a community-based cohort study

    Yoshiro Saito, Misaki Shimizu, Mitsuharu Sato, An Masuda, Kotoko Arisawa, Keiko Taguchi, Takashi Toyama, Ikuko N. Motoike, Kengo Kinoshita, Seizo Koshiba, Masayuki Yamamoto, Toshinari Takamura

    SCIENTIFIC REPORTS　15　(1)　2025/07/13

    DOI： 10.1038/s41598-025-10581-2 　

    ISSN： 2045-2322

  6. Sequential Plasma Metabolome and Proteome Analyses to Develop a Novel Monitoring Strategy for Patients with Epithelial Ovarian Cancer: A Pilot Study. International-journal

    Eiji Hishinuma, Shogo Shigeta, Naomi Matsukawa, Yasunobu Okamura, Ikuko N Motoike, Takamichi Minato, Yusuke Shibuya, Jun Yasuda, Kengo Kinoshita, Seizo Koshiba, Muneaki Shimada

    International journal of molecular sciences　26　(12)　2025/06/06

    DOI： 10.3390/ijms26125435 　

    ISSN： 1661-6596

    eISSN： 1422-0067

  7. Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies. International-journal

    Shun Kodate, Mitsuharu Sato, Eiji Hishinuma, Kaname Kojima, Ikuko N Motoike, Seizo Koshiba, Masayuki Yamamoto, Kazunori D Yamada, Kengo Kinoshita

    Scientific reports　15　(1)　17035-17035　2025/05/16

    DOI： 10.1038/s41598-025-01634-7 　

    ISSN： 2045-2322

  8. Genome-Wide Association Study of Intraocular Pressure in Population-Based Cohorts in Japan: The Tohoku Medical Megabank Organization Eye Study. International-journal

    Nobuo Fuse, Hayato Anzawa, Miyuki Sakurai, Ikuko N Motoike, Satoshi Nagaie, Tomohiro Nakamura, Akiko Miyazawa, Eiichi N Kodama, Masatsugu Orui, Yohei Hamanaka, Tomoko Kobayashi, Akira Uruno, Makiko Taira, Ritsuko Shimizu, Naoki Nakaya, Mami Ishikuro, Taku Obara, Fuji Nagami, Soichi Ogishima, Fumiki Katsuoka, Kazuki Kumada, Shinichi Kuriyama, Atsushi Hozawa, Yoko Izumi, Kengo Kinoshita, Masayuki Yamamoto

    Ophthalmology science　5　(5)　100821-100821　2025

    DOI： 10.1016/j.xops.2025.100821 　

    ISSN： 2666-9145

  9. Histological and genetic features and therapeutic responses of lung cancers explored via the global analysis of their metabolome profile International-journal

    Daisuke Narita, Eiji Hishinuma, Risa Ebina-Shibuya, Eisaku Miyauchi, Naomi Matsukawa, Ikuko N. Motoike, Kengo Kinoshita, Seizo Koshiba, Yoko Tsukita, Hirotsugu Notsuda, Nozomu Kimura, Ryota Saito, Hisatoshi Sugiura

    Lung Cancer　200　108082-108082　2025/01

    DOI： 10.1016/j.lungcan.2025.108082 　

    ISSN： 0169-5002

    eISSN： 1872-8332

  10. 健康調査における眼圧のゲノムワイド関連解析

    布施 昇男, 安澤 隼人, 元池 育子, 櫻井 美由紀, 木下 賢吾, 山本 雅之

    日本緑内障学会抄録集　35回　81-81　2024/09

    Publisher: 日本緑内障学会

  11. Association of olfactory and cognitive function test scores with hippocampal and amygdalar grey matter volume: a cross-sectional study. International-journal

    Shuichi Sato, Takao Imaeda, Shunji Mugikura, Naoko Mori, Masaki Takanashi, Kazumi Hayakawa, Tomo Saito, Makiko Taira, Akira Narita, Mana Kogure, Ippei Chiba, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Ryosuke Ishiwata, Tomohiro Nakamura, Ikuko N Motoike, Naoki Nakaya, Seizo Koshiba, Kengo Kinoshita, Shinichi Kuriyama, Soichi Ogishima, Fuji Nagami, Nobuo Fuse, Atsushi Hozawa

    Scientific reports　14　(1)　19138-19138　2024/08/19

    DOI： 10.1038/s41598-024-69726-4 　

    ISSN： 2045-2322

  12. Identifying critical age and gender-based metabolomic shifts in a Japanese population of the Tohoku Medical Megabank cohort. International-journal

    Miyuki Sakurai, Ikuko N Motoike, Eiji Hishinuma, Yuichi Aoki, Shu Tadaka, Mana Kogure, Masatsugu Orui, Mami Ishikuro, Taku Obara, Naoki Nakaya, Kazuki Kumada, Atsushi Hozawa, Shinichi Kuriyama, Masayuki Yamamoto, Seizo Koshiba, Kengo Kinoshita

    Scientific reports　14　(1)　15681-15681　2024/07/08

    DOI： 10.1038/s41598-024-66180-0 　

    ISSN： 2045-2322

  13. A principal component analysis of metabolome and cognitive decline among Japanese older adults: cross-sectional analysis using Tohoku Medical Megabank Cohort Study.

    Sakura Kiuchi, Kumi Nakaya, Upul Cooray, Kenji Takeuchi, Ikuko N Motoike, Naoki Nakaya, Yasuyuki Taki, Seizo Koshiba, Shunji Mugikura, Ken Osaka, Atsushi Hozawa

    Journal of epidemiology　35　(1)　39-46　2024/07/06

    DOI： 10.2188/jea.JE20240099 　

    ISSN： 0917-5040

  14. Dietary habits and plasma lipid concentrations in a general Japanese population. International-journal

    Mitsuharu Sato, Eiji Hishinuma, Naomi Matsukawa, Yoshiko Shima, Daisuke Saigusa, Ikuko N Motoike, Mana Kogure, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Masayuki Yamamoto, Seizo Koshiba, Kengo Kinoshita

    Metabolomics : Official journal of the Metabolomic Society　20　(2)　34-34　2024/03/05

    DOI： 10.1007/s11306-024-02087-1 　

    ISSN： 1573-3882

    eISSN： 1573-3890

  15. Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals. International-journal

    Yu-Ichi Aoki, Keiko Taguchi, Hayato Anzawa, Junko Kawashima, Noriko Ishida, Akihito Otuki, Atsushi Hasegawa, Liam Baird, Takafumi Suzuki, Ikuko N Motoike, Kinuko Ohneda, Kazuki Kumada, Fumiki Katsuoka, Kengo Kinoshita, Masayuki Yamamoto

    Journal of biochemistry　175　(6)　611-627　2024/01/24

    DOI： 10.1093/jb/mvae008 　

    ISSN： 0021-924X

    eISSN： 1756-2651

  16. jMorp: Japanese Multi-Omics Reference Panel update report 2023. International-journal

    Shu Tadaka, Junko Kawashima, Eiji Hishinuma, Sakae Saito, Yasunobu Okamura, Akihito Otsuki, Kaname Kojima, Shohei Komaki, Yuichi Aoki, Takanari Kanno, Daisuke Saigusa, Jin Inoue, Matsuyuki Shirota, Jun Takayama, Fumiki Katsuoka, Atsushi Shimizu, Gen Tamiya, Ritsuko Shimizu, Masahiro Hiratsuka, Ikuko N Motoike, Seizo Koshiba, Makoto Sasaki, Masayuki Yamamoto, Kengo Kinoshita

    Nucleic acids research　52　(D1)　D622-D632　2023/11/01

    DOI： 10.1093/nar/gkad978 　

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    Modern medicine is increasingly focused on personalized medicine, and multi-omics data is crucial in understanding biological phenomena and disease mechanisms. Each ethnic group has its unique genetic background with specific genomic variations influencing disease risk and drug response. Therefore, multi-omics data from specific ethnic populations are essential for the effective implementation of personalized medicine. Various prospective cohort studies, such as the UK Biobank, All of Us and Lifelines, have been conducted worldwide. The Tohoku Medical Megabank project was initiated after the Great East Japan Earthquake in 2011. It collects biological specimens and conducts genome and omics analyses to build a basis for personalized medicine. Summary statistical data from these analyses are available in the jMorp web database (https://jmorp.megabank.tohoku.ac.jp), which provides a multidimensional approach to the diversity of the Japanese population. jMorp was launched in 2015 as a public database for plasma metabolome and proteome analyses and has been continuously updated. The current update will significantly expand the scale of the data (metabolome, genome, transcriptome, and metagenome). In addition, the user interface and backend server implementations were rewritten to improve the connectivity between the items stored in jMorp. This paper provides an overview of the new version of the jMorp.

  17. Identification of predictive biomarkers for endometrial cancer diagnosis and treatment response monitoring using plasma metabolome profiling International-journal

    Eiji Hishinuma, Muneaki Shimada, Naomi Matsukawa, Yoshiko Shima, Bin Li, Ikuko N. Motoike, Yusuke Shibuya, Tatsuya Hagihara, Shogo Shigeta, Hideki Tokunaga, Daisuke Saigusa, Kengo Kinoshita, Seizo Koshiba, Nobuo Yaegashi

    Cancer &amp; Metabolism　11　(1)　16-16　2023/10/11

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s40170-023-00317-z 　

    eISSN： 2049-3002

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    Abstract Background Endometrial cancer (EMC) is the most common female genital tract malignancy with an increasing prevalence in many countries including Japan, a fact that renders early detection and treatment necessary to protect health and fertility. Although early detection and treatment are necessary to further improve the prognosis of women with endometrial cancer, biomarkers that accurately reflect the pathophysiology of EMC patients are still unclear. Therefore, it is clinically critical to identify biomarkers to assess diagnosis and treatment efficacy to facilitate appropriate treatment and development of new therapies for EMC. Methods In this study, wide-targeted plasma metabolome analysis was performed to identify biomarkers for EMC diagnosis and the prediction of treatment responses. The absolute quantification of 628 metabolites in plasma samples from 142 patients with EMC was performed using ultra-high-performance liquid chromatography with tandem mass spectrometry. Results The concentrations of 111 metabolites increased significantly, while the concentrations of 148 metabolites decreased significantly in patients with EMC compared to healthy controls. Specifically, LysoPC and TGs, including unsaturated fatty acids, were reduced in patients with stage IA EMC compared to healthy controls, indicating that these metabolic profiles could be used as early diagnostic markers of EMC. In contrast, blood levels of amino acids such as histidine and tryptophan decreased as the risk of recurrence increased and the stages of EMC advanced. Furthermore, a marked increase in total TG and a decrease in specific TGs and free fatty acids including polyunsaturated fatty acids levels were observed in patients with EMC. These results suggest that the polyunsaturated fatty acids in patients with EMC are crucial for disease progression. Conclusions Our data identified specific metabolite profiles that reflect the pathogenesis of EMC and showed that these metabolites correlate with the risk of recurrence and disease stage. Analysis of changes in plasma metabolite profiles could be applied for the early diagnosis and monitoring of the course of treatment of EMC patients.

  18. Association Between Olfactory Test Data with Multiple Levels of Odor Intensity and Suspected Cognitive Impairment: A Cross-Sectional Study. International-journal Peer-reviewed

    Shuichi Sato, Takao Imaeda, Shunji Mugikura, Naoko Mori, Masaki Takanashi, Kazumi Hayakawa, Tomo Saito, Makiko Taira, Akira Narita, Mana Kogure, Ippei Chiba, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Ryosuke Ishiwata, Tomohiro Nakamura, Ikuko N Motoike, Naoki Nakaya, Seizo Koshiba, Kengo Kinoshita, Shinichi Kuriyama, Soichi Ogishima, Fuji Nagami, Nobuo Fuse, Atsushi Hozawa

    Journal of Alzheimer's disease : JAD　95　(4)　1469-1480　2023/09/11

    DOI： 10.3233/JAD-230318 　

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    BACKGROUND: Olfactory function decline has recently been reported to be associated with a risk of cognitive impairment. Few population-based studies have included younger adults when examining the association between olfactory test data with multiple odor intensities and suspected cognitive impairment. OBJECTIVE: We investigated the association between high-resolution olfactory test data with fewer odors and suspected cognitive impairments. We also examined the differences between older and younger adults in this association. METHODS: The Japanese version of the Montreal Cognitive Assessment (MoCA-J) was administered to 1,450 participants, with three odor-intensity-level olfactometry using six different odors. Logistic regressions to discriminate suspected cognitive impairment were conducted to examine the association, adjusted for age, sex, education duration, and smoking history. Data were collected from the Program by Tohoku University Tohoku Medical Megabank Organization, with an additional olfactory test conducted between 2019 and 2021. RESULTS: We generally observed that the lower the limit of distinguishable odor intensity was, the higher the MoCA-J score was. The combination of spearmint and stuffy socks contributed most to the distinction between suspected and unsuspected cognitive impairment. Furthermore, the association was significant in women aged 60-74 years (adjusted odds ratio 0.881, 95% confidence interval [0.790, 0.983], p = 0.024). CONCLUSIONS: The results indicate an association between the limit of distinguishable odor intensity and cognitive function. The olfactory test with multiple odor intensity levels using fewer odors may be applicable for the early detection of mild cognitive impairment, especially in older women aged 60-74 years.

  19. Statistical Modeling of Subjective Sleep Quality

    S. Choilek, A. Karashima, I. Motoike, N. Katayama, K. Kinoshita, M. Nakao

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference　2023　1-6　2023/07/01

    DOI： 10.1109/EMBC40787.2023.10340638 　

    eISSN： 2694-0604

  20. Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background Peer-reviewed

    Makiko Taira, Shunji Mugikura, Naoko Mori, Atsushi Hozawa, Tomo Saito, Tomohiro Nakamura, Hideyasu Kiyomoto, Tadao Kobayashi, Soichi Ogishima, Fuji Nagami, Akira Uruno, Ritsuko Shimizu, Tomoko Kobayashi, Jun Yasuda, Shigeo Kure, Miyuki Sakurai, Ikuko N. Motoike, Kazuki Kumada, Naoki Nakaya, Taku Obara, Kentaro Oba, Atsushi Sekiguchi, Benjamin Thyreau, Tatsushi Mutoh, Yuji Takano, Mitsunari Abe, Norihide Maikusa, Yasuko Tatewaki, Yasuyuki Taki, Nobuo Yaegashi, Hiroaki Tomita, Kengo Kinoshita, Shinichi Kuriyama, Nobuo Fuse, Masayuki Yamamoto

    JMA Journal　6　(3)　246-264　2023/07

    DOI： 10.31662/jmaj.2022-0220 　

    ISSN： 2433-328X

    eISSN： 2433-3298

  21. Identification of predictive biomarkers for diagnosis and radiation sensitivity of uterine cervical cancer using wide-targeted metabolomics. International-journal

    Eiji Hishinuma, Muneaki Shimada, Naomi Matsukawa, Bin Li, Ikuko N Motoike, Tatsuya Hagihara, Shogo Shigeta, Hideki Tokunaga, Daisuke Saigusa, Kengo Kinoshita, Seizo Koshiba, Nobuo Yaegashi

    The journal of obstetrics and gynaecology research　49　(8)　2109-2117　2023/06/09

    DOI： 10.1111/jog.15709 　

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    AIM: Uterine cervical cancer (UCC) is the fourth most common cancer in women, responsible for more than 300 000 deaths worldwide. Its early detection, by cervical cytology, and prevention, by vaccinating against human papilloma virus, greatly contribute to reducing cervical cancer mortality in women. However, penetration of the effective prevention of UCC in Japan remains low. Plasma metabolome analysis is widely used for biomarker discovery and the identification of cancer-specific metabolic pathways. Here, we aimed to identify predictive biomarkers for the diagnosis and radiation sensitivity of UCC using wide-targeted plasma metabolomics. METHODS: We analyzed 628 metabolites in plasma samples obtained from 45 patients with UCC using ultra-high-performance liquid chromatography with tandem mass spectrometry. RESULTS: The levels of 47 metabolites were significantly increased and those of 75 metabolites were significantly decreased in patients with UCC relative to healthy controls. Increased levels of arginine and ceramides, and decreased levels of tryptophan, ornithine, glycosylceramides, lysophosphatidylcholine, and phosphatidylcholine were characteristic of patients with UCC. Comparison of metabolite profiles in groups susceptible and non-susceptible to radiation therapy, a treatment for UCC, revealed marked variations in polyunsaturated fatty acid, nucleic acid, and arginine metabolism in the group not susceptible to treatment. CONCLUSIONS: Our findings suggest that the metabolite profile of patients with UCC may be an important indicator for distinguishing these patients from healthy cohorts, and may also be useful for predicting sensitivity to radiotherapy.

  22. Relationship between age-related hearing loss and consumption of coffee and tea.

    Gosuke Watarai, Jun Suzuki, Ikuko N Motoike, Miyuki Sakurai, Ryoukichi Ikeda, Tetsuaki Kawase, Kengo Kinoshita, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Fuse, Masayuki Yamamoto, Yukio Katori

    Geriatrics & gerontology international　2023/05/03

    DOI： 10.1111/ggi.14589 　

  23. Decreased β‐hydroxybutyrate and ketogenic amino acid levels in depressed human adults

    Shiho Sato, Zhiqian Yu, Mai Sakai, Ikuko N. Motoike, Daisuke Saigusa, Ryo Hirayama, Yoshie Kikuchi, Takaaki Abe, Kengo Kinoshita, Seizo Koshiba, Hiroaki Tomita

    European Journal of Neuroscience　2023/02/07

    Publisher: Wiley

    DOI： 10.1111/ejn.15931 　

    ISSN： 0953-816X

    eISSN： 1460-9568

  24. 血清メタボロームと認知機能変化の関連 NILS-LSAの観察結果から

    寳澤 篤, 大塚 礼, 張 シュ, 菱沼 英史, 元池 育子, 三枝 大輔, 中谷 直樹, 小柴 生造, 荒井 秀典

    Journal of Epidemiology　33　(Suppl.1)　87-87　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  25. Plasma metabolic disturbances during pregnancy and postpartum in women with depression. International-journal Peer-reviewed

    Zhiqian Yu, Naomi Matsukawa, Daisuke Saigusa, Ikuko N Motoike, Chiaki Ono, Yasunobu Okamura, Tomomi Onuma, Yuta Takahashi, Mai Sakai, Hisaaki Kudo, Taku Obara, Keiko Murakami, Matusyuki Shirota, Saya Kikuchi, Natsuko Kobayashi, Yoshie Kikuchi, Junichi Sugawara, Naoko Minegishi, Soichi Ogishima, Kengo Kinoshita, Masayuki Yamamoto, Nobuo Yaegashi, Shinichi Kuriyama, Seizo Koshiba, Hiroaki Tomita

    iScience　25　(12)　105666-105666　2022/12/22

    DOI： 10.1016/j.isci.2022.105666 　

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    Examining plasma metabolic profiling during pregnancy and postpartum could help clinicians understand the risk factors for postpartum depression (PPD) development. This analysis targeted paired plasma metabolites in mid-late gestational and 1 month postpartum periods in women with (n = 209) or without (n = 222) PPD. Gas chromatogram-mass spectrometry was used to analyze plasma metabolites at these two time points. Among the 170 objected plasma metabolites, principal component analysis distinguished pregnancy and postpartum metabolites but failed to discriminate women with and without PPD. Compared to women without PPD, those with PPD exhibited 37 metabolites with disparate changes during pregnancy and the 1-month postpartum period and an enriched citrate cycle. Machine learning and multivariate statistical analysis identified two or three compounds that could be potential biomarkers for PPD prediction during pregnancy. Our findings suggest metabolic disturbances in women with depression and may help to elucidate metabolic processes associated with PPD development.

  26. Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment

    Yota Tatara, Hiromi Yamazaki, Fumiki Katsuoka, Mitsuru Chiba, Daisuke Saigusa, Shuya Kasai, Tomohiro Nakamura, Jin Inoue, Yuichi Aoki, Miho Shoji, Ikuko Motoike, Yoshinori Tamada, Katsuhito Hashizume, Mikio Shoji, Kengo Kinoshita, Koichi Murashita, Shigeyuki Nakaji, Masayuki Yamamoto, Ken Itoh

    Current Research in Translational Medicine　71　(1)　103367-103367　2022/10

    Publisher: Elsevier BV

    DOI： 10.1016/j.retram.2022.103367 　

    ISSN： 2452-3186

  27. Selective Elimination of NRF2-Activated Cells by Competition with Neighboring Cells in the Esophageal Epithelium. International-journal

    Wataru Hirose, Makoto Horiuchi, Donghan Li, Ikuko N Motoike, Lin Zhang, Hafumi Nishi, Yusuke Taniyama, Takashi Kamei, Mikiko Suzuki, Kengo Kinoshita, Fumiki Katsuoka, Keiko Taguchi, Masayuki Yamamoto

    Cellular and molecular gastroenterology and hepatology　15　(1)　153-178　2022/09/14

    DOI： 10.1016/j.jcmgh.2022.09.004 　

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    BACKGROUND & AIMS: NF-E2-related factor 2 (NRF2) is a transcription factor that regulates cytoprotective gene expression in response to oxidative and electrophilic stresses. NRF2 activity is mainly controlled by Kelch-like ECH-associated protein 1 (KEAP1). Constitutive NRF2 activation by NRF2 mutations or KEAP1 dysfunction results in a poor prognosis for esophageal squamous cell carcinoma (ESCC) through the activation of cytoprotective functions. However, the detailed contributions of NRF2 to ESCC initiation or promotion have not been clarified. Here, we investigated the fate of NRF2-activated cells in the esophageal epithelium. METHODS: We generated tamoxifen-inducible, squamous epithelium-specific Keap1 conditional knockout (Keap1-cKO) mice in which NRF2 was inducibly activated in a subset of cells at the adult stage. Histological, quantitative reverse-transcription polymerase chain reaction (qRT‒PCR), single-cell RNA-sequencing (RNA-seq) and carcinogen experiments were conducted to analyze the Keap1-cKO esophagus. RESULTS: KEAP1-deleted/NRF2-activated cells and cells with normal NRF2 expression (KEAP1-normal cells) coexisted in the Keap1-cKO esophageal epithelium in approximately equal numbers, and NRF2-activated cells formed dysplastic lesions. NRF2-activated cells exhibited weaker attachment to the basement membrane and gradually disappeared from the epithelium. In contrast, neighboring KEAP1-normal cells exhibited accelerated proliferation and started dominating the epithelium but accumulated DNA damage that triggered carcinogenesis upon carcinogen exposure. CONCLUSIONS: Constitutive NRF2 activation promotes the selective elimination of epithelial cells via cell competition, but this competition induces DNA damage in neighboring KEAP1-normal cells, which predisposes them to chemical-induced ESCC.

  28. Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan

    Nobuo Fuse, Miyuki Sakurai, Ikuko N. Motoike, Kaname Kojima, Takako Takai-Igarashi, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Akiko Miyazawa, Kei Homma, Keisuke Ido, Makiko Taira, Tomoko Kobayashi, Ritsuko Shimizu, Akira Uruno, Eiichi N. Kodama, Kichiya Suzuki, Yohei Hamanaka, Hiroaki Tomita, Junichi Sugawara, Yoichi Suzuki, Fuji Nagami, Soichi Ogishima, Fumiki Katsuoka, Naoko Minegishi, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Yaegashi, Shigeo Kure, Kengo Kinoshita, Masayuki Yamamoto

    Ophthalmology Science　2　(1)　100113-100113　2022/03

    Publisher: Elsevier BV

    DOI： 10.1016/j.xops.2022.100113 　

    ISSN： 2666-9145

  29. dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project

    Soichi Ogishima, Satoshi Nagaie, Satoshi Mizuno, Ryosuke Ishiwata, Keita Iida, Kazuro Shimokawa, Takako Takai-Igarashi, Naoki Nakamura, Sachiko Nagase, Tomohiro Nakamura, Naho Tsuchiya, Naoki Nakaya, Keiko Murakami, Fumihiko Ueno, Tomomi Onuma, Mami Ishikuro, Taku Obara, Shunji Mugikura, Hiroaki Tomita, Akira Uruno, Tomoko Kobayashi, Akito Tsuboi, Shu Tadaka, Fumiki Katsuoka, Akira Narita, Mika Sakurai, Satoshi Makino, Gen Tamiya, Yuichi Aoki, Ritsuko Shimizu, Ikuko N. Motoike, Seizo Koshiba, Naoko Minegishi, Kazuki Kumada, Takahiro Nobukuni, Kichiya Suzuki, Inaho Danjoh, Fuji Nagami, Kozo Tanno, Hideki Ohmomo, Koichi Asahi, Atsushi Shimizu, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Fuse, Teiji Tominaga, Shigeo Kure, Nobuo Yaegashi, Kengo Kinoshita, Makoto Sasaki, Hiroshi Tanaka, Masayuki Yamamoto

    HUMAN GENOME VARIATION　8　(1)　2021/12

    DOI： 10.1038/s41439-021-00175-5 　

    eISSN： 2054-345X

  30. Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator

    Mitsuhiro Yamada, Ikuko N. Motoike, Kaname Kojima, Nobuo Fuse, Atsushi Hozawa, Shinichi Kuriyama, Fumiki Katsuoka, Shu Tadaka, Matsuyuki Shirota, Miyuki Sakurai, Tomohiro Nakamura, Yohei Hamanaka, Kichiya Suzuki, Junichi Sugawara, Soichi Ogishima, Akira Uruno, Eiichi N. Kodama, Naoya Fujino, Tadahisa Numakura, Tomohiro Ichikawa, Ayumi Mitsune, Takashi Ohe, Kengo Kinoshita, Masakazu Ichinose, Hisatoshi Sugiura, Masayuki Yamamoto

    COMMUNICATIONS BIOLOGY　4　(1)　2021/11

    DOI： 10.1038/s42003-021-02813-8 　

    eISSN： 2399-3642

  31. 多層オミックスと機械学習による軽度認知障害の予測モデルの構築

    多田羅 洋太, 中村 智洋, 千葉 満, 三枝 大輔, 山嵜 博未, 勝岡 史城, 葛西 秋宅, 川瀬 倫子, 本間 リナ, 松田 りら, 藤本 哲太, 荘司 美穂, 元池 育子, 玉田 嘉紀, 橋爪 克仁, 東海林 幹夫, 木下 賢吾, 伊東 健

    Dementia Japan　35　(4)　660-660　2021/10

    Publisher: (一社)日本認知症学会

    ISSN： 1342-646X

  32. Subjective sleep quality, quantitative sleep features, and their associations dependent on demographic characteristics, habitual sleep–wake patterns, and distinction of weekdays/weekends

    Siwalee Choilek, Akihiro Karashima, Ikuko Motoike, Norihiro Katayama, Kengo Kinoshita, Mitsuyuki Nakao

    Sleep and Biological Rhythms　19　(4)　369-381　2021/10

    DOI： 10.1007/s41105-021-00326-9 　

    ISSN： 1446-9235

    eISSN： 1479-8425

  33. Comparison of Kit-Based Metabolomics with Other Methodologies in a Large Cohort, towards Establishing Reference Values

    Daisuke Saigusa, Eiji Hishinuma, Naomi Matsukawa, Masatomo Takahashi, Jin Inoue, Shu Tadaka, Ikuko N. Motoike, Atsushi Hozawa, Yoshihiro Izumi, Takeshi Bamba, Kengo Kinoshita, Kim Ekroos, Seizo Koshiba, Masayuki Yamamoto

    Metabolites　11　(10)　652-652　2021/09/24

    Publisher: MDPI AG

    DOI： 10.3390/metabo11100652 　

    eISSN： 2218-1989

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    Metabolic profiling is an omics approach that can be used to observe phenotypic changes, making it particularly attractive for biomarker discovery. Although several candidate metabolites biomarkers for disease expression have been identified in recent clinical studies, the reference values of healthy subjects have not been established. In particular, the accuracy of concentrations measured by mass spectrometry (MS) is unclear. Therefore, comprehensive metabolic profiling in large-scale cohorts by MS to create a database with reference ranges is essential for evaluating the quality of the discovered biomarkers. In this study, we tested 8700 plasma samples by commercial kit-based metabolomics and separated them into two groups of 6159 and 2541 analyses based on the different ultra-high-performance tandem mass spectrometry (UHPLC-MS/MS) systems. We evaluated the quality of the quantified values of the detected metabolites from the reference materials in the group of 2541 compared with the quantified values from other platforms, such as nuclear magnetic resonance (NMR), supercritical fluid chromatography tandem mass spectrometry (SFC-MS/MS) and UHPLC-Fourier transform mass spectrometry (FTMS). The values of the amino acids were highly correlated with the NMR results, and lipid species such as phosphatidylcholines and ceramides showed good correlation, while the values of triglycerides and cholesterol esters correlated less to the lipidomics analyses performed using SFC-MS/MS and UHPLC-FTMS. The evaluation of the quantified values by MS-based techniques is essential for metabolic profiling in a large-scale cohort.

  34. Wide-Targeted Metabolome Analysis Identifies Potential Biomarkers for Prognosis Prediction of Epithelial Ovarian Cancer. International-journal

    Eiji Hishinuma, Muneaki Shimada, Naomi Matsukawa, Daisuke Saigusa, Bin Li, Kei Kudo, Keita Tsuji, Shogo Shigeta, Hideki Tokunaga, Kazuki Kumada, Keigo Komine, Hidekazu Shirota, Yuichi Aoki, Ikuko N Motoike, Jun Yasuda, Kengo Kinoshita, Masayuki Yamamoto, Seizo Koshiba, Nobuo Yaegashi

    Toxins　13　(7)　2021/06/30

    DOI： 10.3390/toxins13070461 　

    eISSN： 2072-6651

  35. Chronic Hypercapnic Respiratory Failure in an Adult Patient with Silver-Russell Syndrome.

    Mariko Hakamata, Satoshi Hokari, Yasuyoshi Ohshima, Masayo Kagami, Sakae Saito, Ikuko N Motoike, Taiki Abe, Nobumasa Aoki, Masachika Hayashi, Satoshi Watanabe, Toshiyuki Koya, Toshiaki Kikuchi

    Internal medicine (Tokyo, Japan)　60　(12)　1921-1926　2021/06/15

    DOI： 10.2169/internalmedicine.5479-20 　

    ISSN： 0918-2918

    eISSN： 1349-7235

  36. Japonica Array NEO with increased genome-wide coverage and abundant disease risk SNPs. International-journal

    Mika Sakurai-Yageta, Kazuki Kumada, Chinatsu Gocho, Satoshi Makino, Akira Uruno, Shu Tadaka, Ikuko N Motoike, Masae Kimura, Shin Ito, Akihito Otsuki, Akira Narita, Hisaaki Kudo, Yuichi Aoki, Inaho Danjoh, Jun Yasuda, Hiroshi Kawame, Naoko Minegishi, Seizo Koshiba, Nobuo Fuse, Gen Tamiya, Masayuki Yamamoto, Kengo Kinoshita

    Journal of biochemistry　170　(3)　399-410　2021/05/13

    DOI： 10.1093/jb/mvab060 　

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    Ethnic-specific SNP arrays are becoming more important to increase the power of genome-wide association studies in diverse population. In the Tohoku Medical Megabank Project, we have been developing a series of Japonica Arrays (JPA) for genotyping participants based on reference panels constructed from whole-genome sequence data of the Japanese population. Here, we designed a novel version of the SNP array for the Japanese population, called Japonica Array NEO (JPA NEO), comprising a total of 666,883 markers. Among them, 654,246 tag SNPs of autosomes and X chromosome were selected from an expanded reference panel of 3,552 Japanese, 3.5KJPNv2, using pairwise r2 of linkage disequilibrium measures. Additionally, 28,298 markers were included for the evaluation of previously identified disease risk markers from the literature and databases, and those present in the Japanese population were extracted using the reference panel. Through genotyping 286 Japanese samples, we found that the imputation quality r2 and INFO score in the minor allele frequency bin >2.5-5% were >0.9 and >0.8, respectively, and >12 million markers were imputed with an INFO score >0.8. From these results, JPA NEO is a promising tool for genotyping the Japanese population with genome-wide coverage, contributing to the development of genetic risk scores.

  37. GWAS Identified IL4R and the Major Histocompatibility Complex Region as the Associated Loci of Total Serum IgE Levels in 9,260 Japanese Individuals. International-journal

    Kosuke Shido, Kaname Kojima, Matsuyuki Shirota, Kenshi Yamasaki, Ikuko N Motoike, Atsushi Hozawa, Soichi Ogishima, Naoko Minegishi, Kozo Tanno, Fumiki Katsuoka, Gen Tamiya, Setsuya Aiba, Masayuki Yamamoto, Kengo Kinoshita

    The Journal of investigative dermatology　141　(11)　2749-2752　2021/04/14

    DOI： 10.1016/j.jid.2021.02.762 　

    ISSN： 0022-202X

    eISSN： 1523-1747

  38. Possible Somatic Mosaicism of Novel FUS Variant in Familial Amyotrophic Lateral Sclerosis. International-journal

    Shin Hisahara, Ayumi Nishiyama, Emiko Tsuda, Syuuichirou Suzuki, Akihiro Matsumura, Aki Ishikawa, Akihiro Sakurai, Ikuko N Motoike, Masashi Aoki, Yoko Aoki, Shun Shimohama

    Neurology. Genetics　7　(1)　e552　2021/02

    DOI： 10.1212/NXG.0000000000000552 　

  39. jMorp updates in 2020: large enhancement of multi-omics data resources on the general Japanese population. International-journal

    Shu Tadaka, Eiji Hishinuma, Shohei Komaki, Ikuko N Motoike, Junko Kawashima, Daisuke Saigusa, Jin Inoue, Jun Takayama, Yasunobu Okamura, Yuichi Aoki, Matsuyuki Shirota, Akihito Otsuki, Fumiki Katsuoka, Atsushi Shimizu, Gen Tamiya, Seizo Koshiba, Makoto Sasaki, Masayuki Yamamoto, Kengo Kinoshita

    Nucleic acids research　49　(D1)　D536-D544　2021/01/08

    DOI： 10.1093/nar/gkaa1034 　

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    In the Tohoku Medical Megabank project, genome and omics analyses of participants in two cohort studies were performed. A part of the data is available at the Japanese Multi Omics Reference Panel (jMorp; https://jmorp.megabank.tohoku.ac.jp) as a web-based database, as reported in our previous manuscript published in Nucleic Acid Research in 2018. At that time, jMorp mainly consisted of metabolome data; however, now genome, methylome, and transcriptome data have been integrated in addition to the enhancement of the number of samples for the metabolome data. For genomic data, jMorp provides a Japanese reference sequence obtained using de novo assembly of sequences from three Japanese individuals and allele frequencies obtained using whole-genome sequencing of 8,380 Japanese individuals. In addition, the omics data include methylome and transcriptome data from ∼300 samples and distribution of concentrations of more than 755 metabolites obtained using high-throughput nuclear magnetic resonance and high-sensitivity mass spectrometry. In summary, jMorp now provides four different kinds of omics data (genome, methylome, transcriptome, and metabolome), with a user-friendly web interface. This will be a useful scientific data resource on the general population for the discovery of disease biomarkers and personalized disease prevention and early diagnosis.

  40. Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers

    Keito Okazaki, Hayato Anzawa, Zun Liu, Nao Ota, Hiroshi Kitamura, Yoshiaki Onodera, Md Morshedul Alam, Daisuke Matsumaru, Takuma Suzuki, Fumiki Katsuoka, Shu Tadaka, Ikuko Motoike, Mika Watanabe, Kazuki Hayasaka, Akira Sakurada, Yoshinori Okada, Masayuki Yamamoto, Takashi Suzuki, Kengo Kinoshita, Hiroki Sekine, Hozumi Motohashi

    Nature Communications　11　(1)　2020/12

    DOI： 10.1038/s41467-020-19593-0 　

    eISSN： 2041-1723

  41. Improved metabolomic data-based prediction of depressive symptoms using nonlinear machine learning with feature selection International-journal Peer-reviewed

    Yuta Takahashi, Masao Ueki, Makoto Yamada, Gen Tamiya, Ikuko N. Motoike, Daisuke Saigusa, Miyuki Sakurai, Fuji Nagami, Soichi Ogishima, Seizo Koshiba, Kengo Kinoshita, Masayuki Yamamoto, Hiroaki Tomita

    Translational Psychiatry　10　(1)　157-157　2020/12/01

    DOI： 10.1038/s41398-020-0831-9 　

    eISSN： 2158-3188

  42. Identification of critical genetic variants associated with metabolic phenotypes of the Japanese population. International-journal

    Seizo Koshiba, Ikuko N Motoike, Daisuke Saigusa, Jin Inoue, Yuichi Aoki, Shu Tadaka, Matsuyuki Shirota, Fumiki Katsuoka, Gen Tamiya, Naoko Minegishi, Nobuo Fuse, Kengo Kinoshita, Masayuki Yamamoto

    Communications biology　3　(1)　662-662　2020/11/11

    DOI： 10.1038/s42003-020-01383-5 　

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    We performed a metabolome genome-wide association study for the Japanese population in the prospective cohort study of Tohoku Medical Megabank. By combining whole-genome sequencing and nontarget metabolome analyses, we identified a large number of novel associations between genetic variants and plasma metabolites. Of the identified metabolite-associated genes, approximately half have already been shown to be involved in various diseases. We identified metabolite-associated genes involved in the metabolism of xenobiotics, some of which are from intestinal microorganisms, indicating that the identified genetic variants also markedly influence the interaction between the host and symbiotic bacteria. We also identified five associations that appeared to be female-specific. A number of rare variants that influence metabolite levels were also found, and combinations of common and rare variants influenced the metabolite levels more profoundly. These results support our contention that metabolic phenotyping provides important insights into how genetic and environmental factors provoke human diseases.

  43. Longitudinal plasma amino acid profiling with maternal genomic background throughout human pregnancy International-journal Peer-reviewed

    Matsuyuki Shirota, Daisuke Saigusa, Riu Yamashita, Yasutake Kato, Mitsuyo Matsumoto, Junya Yamagishi, Noriko Ishida, Kazuki Kumada, Yuji Oe, Hisaaki Kudo, Junji Yokozawa, Yoko Kuroki, Ikuko Motoike, Fumiki Katsuoka, Masao Nagasaki, Seizo Koshiba, Keiko Nakayama, Osamu Tanabe, Jun Yasuda, Shigeo Kure, Kengo Kinoshita, Hirohito Metoki, Shinichi Kuriyama, Nobuo Yaegashi, Masayuki Yamamoto, Junichi Sugawara

    Medical Mass Spectrometry　4　(1)　36-49　2020/04/16

    DOI： 10.24508/mms.2020.06.001 　

  44. Impacts of NRF2 activation in non–small-cell lung cancer cell lines on extracellular metabolites International-journal Peer-reviewed

    Daisuke Saigusa, Ikuko N. Motoike, Sakae Saito, Michael Zorzi, Yuichi Aoki, Hiroshi Kitamura, Mikiko Suzuki, Fumiki Katsuoka, Hirofumi Ishii, Kengo Kinoshita, Hozumi Motohashi, Masayuki Yamamoto

    Cancer Science　111　(2)　667-678　2020/02/01

    DOI： 10.1111/cas.14278 　

    ISSN： 1347-9032

    eISSN： 1349-7006

  45. Consistency index of daily activity pattern and its correlations with subjective ratings of QOL Peer-reviewed

    Ryota Amano, Akihiro Karashima, Ikuko Motoike, Norihiro Katayama, Kengo Kinoshita, Mitsuyuki Nakao

    Sleep and Biological Rhythms　18　(4)　297-304　2020

    DOI： 10.1007/s41105-020-00271-z 　

    ISSN： 1446-9235

    eISSN： 1479-8425

  46. Relationship between Dynamics of Physiological Signals and Subjective Quality of Life and Its Lifestyle Dependency Peer-reviewed

    R. Amano, A. Karashima, I. Motoike, N. Katayama, K. Kinoshita, M. Nakao

    Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS　546-549　2019/07

    DOI： 10.1109/EMBC.2019.8857083 　

    ISSN： 1557-170X

  47. メタボロームデータを用いた非線形変数選択機械学習によるうつ状態の予測

    高橋 雄太, 植木 優夫, 山田 誠, 田宮 元, 元池 育子, 三枝 大輔, 櫻井 美由紀, 長神 風二, 小柴 生造, 木下 賢吾, 山本 雅之, 富田 博秋

    精神神経学雑誌　(2019特別号)　S609-S609　2019/06

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  48. Identification of genetic alterations in extramammary Paget disease using whole exome analysis International-journal Peer-reviewed

    Yukiko Kiniwa, Jun Yasuda, Sakae Saito, Rumiko Saito, Ikuko N. Motoike, Inaho Danjoh, Kengo Kinoshita, Nobuo Fuse, Masayuki Yamamoto, Ryuhei Okuyama

    Journal of Dermatological Science　94　(1)　229-235　2019/04

    DOI： 10.1016/j.jdermsci.2019.03.006 　

    ISSN： 0923-1811

    eISSN： 1873-569X

  49. Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare International-journal Peer-reviewed

    Jun Yasuda, Kengo Kinoshita, Fumiki Katsuoka, Inaho Danjoh, Mika Sakurai-Yageta, Ikuko N. Motoike, Yoko Kuroki, Sakae Saito, Kaname Kojima, Matsuyuki Shirota, Daisuke Saigusa, Akihito Otsuki, Junko Kawashima, Yumi Yamaguchi-Kabata, Shu Tadaka, Yuichi Aoki, Takahiro Mimori, Kazuki Kumada, Jin Inoue, Satoshi Makino, Miho Kuriki, Nobuo Fuse, Seizo Koshiba, Osamu Tanabe, Masao Nagasaki, Gen Tamiya, Ritsuko Shimizu, Takako Takai-Igarashi, Soichi Ogishima, Atsushi Hozawa, Shinichi Kuriyama, Junichi Sugawara, Akito Tsuboi, Hideyasu Kiyomoto, Tadashi Ishii, Hiroaki Tomita, Naoko Minegishi, Yoichi Suzuki, Kichiya Suzuki, Hiroshi Kawame, Hiroshi Tanaka, Yasuyuki Taki, Nobuo Yaegashi, Shigeo Kure, Fuji Nagami, Kenjiro Kosaki, Yoichi Sutoh, Tsuyoshi Hachiya, Atsushi Shimizu, Makoto Sasaki, Masayuki Yamamoto

    Journal of Biochemistry　165　(2)　139-158　2019/02/01

    Publisher: Journal of Biochemistry

    DOI： 10.1093/jb/mvy096 　

    ISSN： 0021-924X

    eISSN： 1756-2651

  50. Genome-wide analysis of glucocorticoid-responsive transcripts in the hypothalamic paraventricular region of male rats International-journal Peer-reviewed

    Keiichi Itoi, Ikuko Motoike, Ying Liu, Sam Clokie, Yasumasa Iwasaki, Katsuya Uchida, Tatsuya Sato, Greti Aguilera

    Endocrinology (United States)　160　(1)　38-54　2019/01/01

    DOI： 10.1210/en.2018-00535 　

    ISSN： 0013-7227

    eISSN： 1945-7170

  51. 3.5KJPNv2: an allele frequency panel of 3552 Japanese individuals including the X chromosome. International-journal Peer-reviewed

    Shu Tadaka, Fumiki Katsuoka, Masao Ueki, Kaname Kojima, Satoshi Makino, Sakae Saito, Akihito Otsuki, Chinatsu Gocho, Mika Sakurai-Yageta, Inaho Danjoh, Ikuko N Motoike, Yumi Yamaguchi-Kabata, Matsuyuki Shirota, Seizo Koshiba, Masao Nagasaki, Naoko Minegishi, Atsushi Hozawa, Shinichi Kuriyama, Atsushi Shimizu, Jun Yasuda, Nobuo Fuse, Gen Tamiya, Masayuki Yamamoto, Kengo Kinoshita

    Human genome variation　6　28-28　2019

    Publisher: Cold Spring Harbor Laboratory

    DOI： 10.1038/s41439-019-0059-5 　

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    The first step towards realizing personalized healthcare is to catalog the genetic variations in a population. Since the dissemination of individual-level genomic information is strictly controlled, it will be useful to construct population-level allele frequency panels with easy-to-use interfaces. In the Tohoku Medical Megabank Project, we sequenced nearly 4000 individuals from a Japanese population and constructed an allele frequency panel of 3552 individuals after removing related samples. The panel is called the 3.5KJPNv2. It was constructed by using a standard pipeline including the 1KGP and gnomAD algorithms to reduce technical biases and to allow comparisons to other populations. Our database is the first large-scale panel providing the frequencies of variants present on the X chromosome and on the mitochondria in the Japanese population. All the data are available on our original database at https://jmorp.megabank.tohoku.ac.jp.

  52. Metabolomic changes in the mouse retina after optic nerve injury International-journal Peer-reviewed

    Kota Sato, Daisuke Saigusa, Ritsumi Saito, Amane Fujioka, Yurika Nakagawa, Koji M. Nishiguchi, Taiki Kokubun, Ikuko N. Motoike, Kazuichi Maruyama, Kazuko Omodaka, Yukihiro Shiga, Akira Uruno, Seizo Koshiba, Masayuki Yamamoto, Toru Nakazawa

    Scientific Reports　8　(1)　11930-11930　2018/12/01

    DOI： 10.1038/s41598-018-30464-z 　

    eISSN： 2045-2322

  53. 自己評価による睡眠の質と関連した、睡眠中の手首運動の定量的特性(Quantitative characterization of wrist movements during sleep in relation to self-rating sleep quality)

    Choilek Siwalee, Motoike Ikuko N., Uchibayashi Toshihiro, Karashima Akihiro, Katayama Norihiro, Nakao Mitsuyuki

    Sleep and Biological Rhythms　16　(4)　480-480　2018/10

    Publisher: (一社)日本睡眠学会

    ISSN： 1446-9235

    eISSN： 1479-8425

  54. Regional genetic differences among Japanese populations and performance of genotype imputation using whole-genome reference panel of the Tohoku Medical Megabank Project International-journal Peer-reviewed

    Jun Yasuda, Fumiki Katsuoka, Inaho Danjoh, Yosuke Kawai, Kaname Kojima, Masao Nagasaki, Sakae Saito, Yumi Yamaguchi-Kabata, Shu Tadaka, Ikuko N. Motoike, Kazuki Kumada, Mika Sakurai-Yageta, Osamu Tanabe, Nobuo Fuse, Gen Tamiya, Koichiro Higasa, Fumihiko Matsuda, Nobufumi Yasuda, Motoki Iwasaki, Makoto Sasaki, Atsushi Shimizu, Kengo Kinoshita, Masayuki Yamamoto

    BMC Genomics　19　(1)　551-551　2018/07/24

    DOI： 10.1186/s12864-018-4942-0 　

    eISSN： 1471-2164

  55. Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project International-journal Peer-reviewed

    Seizo Koshiba, Ikuko Motoike, Daisuke Saigusa, Jin Inoue, Matsuyuki Shirota, Yasutake Katoh, Fumiki Katsuoka, Inaho Danjoh, Atsushi Hozawa, Shinichi Kuriyama, Naoko Minegishi, Masao Nagasaki, Takako Takai-Igarashi, Soichi Ogishima, Nobuo Fuse, Shigeo Kure, Gen Tamiya, Osamu Tanabe, Jun Yasuda, Kengo Kinoshita, Masayuki Yamamoto

    Genes to Cells　23　(6)　406-417　2018/06

    DOI： 10.1111/gtc.12588 　

    ISSN： 1356-9597

    eISSN： 1365-2443

  56. Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2049 individuals article International-journal Peer-reviewed

    Yumi Yamaguchi-Kabata, Jun Yasuda, Osamu Tanabe, Yoichi Suzuki, Hiroshi Kawame, Nobuo Fuse, Masao Nagasaki, Yosuke Kawai, Kaname Kojima, Fumiki Katsuoka, Sakae Saito, Inaho Danjoh, Ikuko N. Motoike, Riu Yamashita, Seizo Koshiba, Daisuke Saigusa, Gen Tamiya, Shigeo Kure, Nobuo Yaegashi, Yoshio Kawaguchi, Fuji Nagami, Shinichi Kuriyama, Junichi Sugawara, Naoko Minegishi, Atsushi Hozawa, Soichi Ogishima, Hideyasu Kiyomoto, Takako Takai-Igarashi, Kengo Kinoshita, Masayuki Yamamoto

    Journal of Human Genetics　63　(2)　213-230　2018/02/01

    DOI： 10.1038/s10038-017-0347-1 　

    ISSN： 1434-5161

    eISSN： 1435-232X

  57. JMorp: Japanese Multi Omics Reference Panel International-journal Peer-reviewed

    Shu Tadaka, Daisuke Saigusa, Ikuko N. Motoike, Jin Inoue, Yuichi Aoki, Matsuyuki Shirota, Seizo Koshiba, Masayuki Yamamoto, Kengo Kinoshita

    Nucleic Acids Research　46　(D1)　D551-D557　2018/01/01

    DOI： 10.1093/nar/gkx978 　

    ISSN： 0305-1048

    eISSN： 1362-4962

  58. The structural origin of metabolic quantitative diversity International-journal Peer-reviewed

    Seizo Koshiba, Ikuko Motoike, Kaname Kojima, Takanori Hasegawa, Matsuyuki Shirota, Tomo Saito, Daisuke Saigusa, Inaho Danjoh, Fumiki Katsuoka, Soichi Ogishima, Yosuke Kawai, Yumi Yamaguchi-Kabata, Miyuki Sakurai, Sachiko Hirano, Junichi Nakata, Hozumi Motohashi, Atsushi Hozawa, Shinichi Kuriyama, Naoko Minegishi, Masao Nagasaki, Takako Takai-Igarashi, Nobuo Fuse, Hideyasu Kiyomoto, Junichi Sugawara, Yoichi Suzuki, Shigeo Kure, Nobuo Yaegashi, Osamu Tanabe, Kengo Kinoshita, Jun Yasuda, Masayuki Yamamoto

    Scientific Reports　6　31463-31463　2016/08/16

    DOI： 10.1038/srep31463 　

    ISSN： 2045-2322

    eISSN： 2045-2322

  59. Establishment of protocols for global metabolomics by LC-MS for biomarker discovery International-journal Peer-reviewed

    Daisuke Saigusa, Yasunobu Okamura, Ikuko N. Motoike, Yasutake Katoh, Yasuhiro Kurosawa, Reina Saijyo, Seizo Koshiba, Jun Yasuda, Hozumi Motohashi, Junichi Sugawara, Osamu Tanabe, Kengo Kinoshita, Masayuki Yamamoto

    PLoS ONE　11　(8)　e0160555　2016/08

    DOI： 10.1371/journal.pone.0160555 　

    ISSN： 1932-6203

    eISSN： 1932-6203

  60. Validation of multiple single nucleotide variation calls by additional exome analysis with a semiconductor sequencer to supplement data of whole-genome sequencing of a human population International-journal Peer-reviewed

    Ikuko N. Motoike, Mitsuyo Matsumoto, Inaho Danjoh, Fumiki Katsuoka, Kaname Kojima, Naoki Nariai, Yukuto Sato, Yumi Yamaguchi-Kabata, Shin Ito, Hisaaki Kudo, Ichiko Nishijima, Satoshi Nishikawa, Xiaoqing Pan, Rumiko Saito, Sakae Saito, Tomo Saito, Matsuyuki Shirota, Kaoru Tsuda, Junji Yokozawa, Kazuhiko Igarashi, Naoko Minegishi, Osamu Tanabe, Nobuo Fuse, Masao Nagasaki, Kengo Kinoshita, Jun Yasuda, Masayuki Yamamoto

    BMC Genomics　15　(1)　673-673　2014/08/10

    DOI： 10.1186/1471-2164-15-673 　

    ISSN： 1471-2164

    eISSN： 1471-2164

  61. Global genetic response in a cancer cell: Self-organized coherent expression dynamics International-journal Peer-reviewed

    Masa Tsuchiya, Midori Hashimoto, Yoshiko Takenaka, Ikuko N. Motoike, Kenichi Yoshikawa

    PLoS ONE　9　(5)　e97411　2014/05/15

    DOI： 10.1371/journal.pone.0097411 　

    ISSN： 1932-6203

    eISSN： 1932-6203

  62. COXPRESdb: A database of comparative gene coexpression networks of eleven species for mammals International-journal Peer-reviewed

    Takeshi Obayashi, Yasunobu Okamura, Satoshi Ito, Shu Tadaka, Ikuko N. Motoike, Kengo Kinoshita

    Nucleic Acids Research　41　(D1)　D1014-20-D1020　2013/01/01

    DOI： 10.1093/nar/gks1014 　

    ISSN： 0305-1048

    eISSN： 1362-4962

  63. Dendritic gates for signal integration with excitability-dependent responsiveness International-journal Peer-reviewed

    Hisako Takigawa-Imamura, Ikuko N. Motoike

    Neural Networks　24　(10)　1143-1152　2011/12

    DOI： 10.1016/j.neunet.2011.05.003 　

    ISSN： 0893-6080

    eISSN： 1879-2782

  64. Density wave propagation of a wave train in a closed excitable medium International-journal Peer-reviewed

    Nobuhiko J. Suematsu, Taisuke Sato, Ikuko N. Motoike, Kenji Kashima, Satoshi Nakata

    Physical Review E - Statistical, Nonlinear, and Soft Matter Physics　84　(4)　046203-046203　2011/10/05

    DOI： 10.1103/PhysRevE.84.046203 　

    ISSN： 1539-3755

    eISSN： 1550-2376

  65. Self-organizing striped and spotted patterns on a discrete reaction-diffusion model Peer-reviewed

    Asai T, Motoike I.N

    Nonlinear Theory and Its Applications　2　(3)　363-371　2011/07/01

    Publisher: The Institute of Electronics, Information and Communication Engineers

    DOI： 10.1588/nolta.2.363 　

    ISSN： 2185-4106

    More details Close

    We propose a novel and simple discrete reaction-diffusion model that self-organizes striped and spotted spatial patterns. Through theoretical analyses, we show that the spatial frequency of the generated patterns is proportional to diffusion length. Through extensive numerical simulations, we demonstrate that the model can produce Turing-like striped and spotted spatial patterns.

  66. Branching pattern formation that reflects the history of signal propagation. International-journal Peer-reviewed

    Ikuko N Motoike, Hisako Takigawa-Imamura

    Physical review. E, Statistical, nonlinear, and soft matter physics　82　(4 Pt 2)　046205-046205　2010/10

    DOI： 10.1103/PhysRevE.82.046205 　

    ISSN： 1550-2376 1539-3755

    eISSN： 1550-2376

    More details Close

    In living organisms, branching structures are often observed in open systems. During the process of structure formation/deformation, signal propagation can be observed. Branching paths often deform depending on the history of signal propagation. To gain a better understanding of the process of pattern formation that results in characteristic geometrical paths, we adopt a system in which the dynamics of path formation are correlated with signal propagation. This model involves both branch-generation dynamics and signal-propagation dynamics, and we introduced positive feedback between these two dynamic processes. We studied the geometrical properties of path deformation and the pattern of signal propagation using a discretized reaction-diffusion model. The proposed model can qualitatively reproduce different branching patterns and means of signal propagation. One remarkable result is that the mutual interaction of these two dynamic processes leads to autonomous wave generation, similar to a pacemaker or the generation of spiral waves. Because the autonomous wave generation in the signal is spontaneous, the shapes of the branching paths become distorted. We discuss the correlation between path deformation and signal propagation as a first step in understanding signal processing for such complex deformable paths.

  67. Apex of a V-shaped cut field acts as a pacemaker on an oscillatory system

    Ikuko N. Motoike, Satoshi Nakata, Yasutaka Iguchi, Kaori K. Takemura, Kumiko Hayashi, Kenichi Yoshikawa

    CHEMICAL PHYSICS LETTERS　490　(4-6)　238-241　2010/04

    DOI： 10.1016/j.cplett.2010.03.046 　

    ISSN： 0009-2614

  68. Image Processing with Neuron-Like Branching Elements (POSTER) Peer-reviewed

    Hisako Takigawa-Imamura, Ikuko N. Motoike

    UNCONVENTIONAL COMPUTATION, PROCEEDINGS　6079　194-194　2010

    ISSN： 0302-9743

  69. Multi-Valued Operations with an Inhomogeneous Reaction-Diffusion Field Peer-reviewed

    MOTOIKE Ikuko N.

    Journal of Chemical Software　9　(3)　121-126　2010

    Publisher: Society of Computer Chemistry, Japan

    DOI： 10.2477/jccj.H2116 　

    ISSN： 1347-1767 1347-3824

    More details Close

    The reaction-diffusion model is well known as a describing equation for chemical reactions on uniform- or non-uniform- spatial fields. This kind of model has been studied in a point of view of representation for spatio-temporal patterns. On the other hand, living systems use wet systems for signal processing in order to maintain their lives. Thus recently an unconventional computation framework utilizing wet, reaction-diffusion features has attracted researchers. Authors have reported that basic signal processing functions are implemented on reaction-diffusion fields, with non-uniform field characteristics. In these studies, propagation of excitation pulse on a reaction-diffusion (excitable) field corresponds to signal propagation. It has been reported that co-incidence detection between a couple of inputs can be realized by suitable arrangement of reaction-diffusion fields on diffusion field in numerical and experimental studies. In this paper time differences of a couple of inputs can be encoded as the number of output pulses by adopting a bursting model that originated from living systems at the detecting point of output field.

  70. Towards Computation in Noisy Reaction-Diffusion Cellular Automata Peer-reviewed

    Hisako Takigawa-Imamura, Ikuko N. Motoike

    2009 INTERNATIONAL SYMPOSIUM ON INTELLIGENT SIGNAL PROCESSING AND COMMUNICATION SYSTEMS (ISPACS 2009)　355-358　2009

  71. Basic Information Processing Operations with Pulses of Excitation in a Reaction-Diffusion System Peer-reviewed

    K. Yoshikawa, I. N. Motoike, T. Ichino, T. Yamaguchi, Y. Igarashi, J. Gorecki, J. N. Gorecka

    INTERNATIONAL JOURNAL OF UNCONVENTIONAL COMPUTING　5　(1)　3-37　2009

    ISSN： 1548-7199

    eISSN： 1548-7202

  72. Single-electron circuits performing dendritic pattern formation with nature-inspired cellular automata Peer-reviewed

    Takahide Oya, Ikuko N. Motoike, Tetsuya Asai

    INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS　17　(10)　3651-3655　2007/10

    DOI： 10.1142/S0218127407019512 　

    ISSN： 0218-1274

  73. Simple modeling of branching pattern formation in a reaction diffusion system with cellular automaton Peer-reviewed

    Ikuko N. Motoike

    JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN　76　(3)　1-34002　2007/03

    DOI： 10.1143/JPSJ.76.034002 　

    ISSN： 0031-9015

  74. A reaction-diffusion model performing stripe- and spot-image restoration and its LSI implementation Peer-reviewed

    Yohei Suzuki, Takahiro Takayama, Ikuko N. Motoike, Tetsuya Asai

    ELECTRONICS AND COMMUNICATIONS IN JAPAN PART III-FUNDAMENTAL ELECTRONIC SCIENCE　90　(1)　20-29　2007

    DOI： 10.1002/ecjc.20243 　

    ISSN： 1042-0967

  75. Striped and spotted pattern generation on reaction-diffusion cellular automata - Theory and LSI implementation Peer-reviewed

    Youhei Suzuki, Takahiro Takayama, Ikuko N. Motoike, Tetsuya Asai

    INTERNATIONAL JOURNAL OF UNCONVENTIONAL COMPUTING　3　(1)　1-13　2007

    ISSN： 1548-7199

  76. Design methodologies for compact logic circuits based on collision-based computing Peer-reviewed

    Kazuhito Yamada, Ikuko N. Motoike, Tetsuya Asai, Yoshihito Amemiya

    IEICE ELECTRONICS EXPRESS　3　(13)　292-298　2006/07

    DOI： 10.1587/elex.3.292 　

    ISSN： 1349-2543

  77. 縞・斑点画像パターンの修復を行う反応拡散モデルとそのLSI化 Peer-reviewed

    Suzuki Y, Takayama T, Motoike I.N, Asai T

    IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences (Japanese Edition)　J87-A　(11)　1272-1281　2005/11/01

    Publisher: The Institute of Electronics, Information and Communication Engineers

    DOI： 10.1587/transfun.J87.A.1272 　

    ISSN： 0913-5707

  78. Three-valued logic gates in reaction-diffusion excitable media Peer-reviewed

    IN Motoike, A Adarnatzky

    CHAOS SOLITONS & FRACTALS　24　(1)　107-114　2005/04

    DOI： 10.1016/j.chaos.2004.07.021 　

    ISSN： 0960-0779

  79. 1P311 Dendritic pattern formation in the discrete reaction-diffusion model

    Motoike I.N.

    Seibutsu Butsuri　45　S109　2005

    Publisher: The Biophysical Society of Japan General Incorporated Association

    DOI： 10.2142/biophys.45.S109_3 　

  80. Information operations with multiple pulses on an excitable field Peer-reviewed

    Ikuko N. Motoike, Kenichi Yoshikawa

    Chaos, Solitons and Fractals　17　(2-3)　455-461　2003/07

    DOI： 10.1016/S0960-0779(02)00388-0 　

    ISSN： 0960-0779

  81. Different operations on a single circuit: Field computation on an excitable chemical system Peer-reviewed

    T Ichino, Y Igarashi, IN Motoike, K Yoshikawa

    JOURNAL OF CHEMICAL PHYSICS　118　(18)　8185-8190　2003/05

    DOI： 10.1063/1.1565103 　

    ISSN： 0021-9606

  82. 3G1515 The signal propagation ntilizing the geometric characteristic of excitable field

    Motoike I.N.

    Seibutsu Butsuri　42　(2)　S167　2002

    Publisher: The Biophysical Society of Japan General Incorporated Association

    DOI： 10.2142/biophys.42.S167_1 　

  83. Information operation utilizing geometry of excitable field

    Motoike I.N

    Seibutsu Butsuri　41　S152　2001

    Publisher: The Biophysical Society of Japan General Incorporated Association

    DOI： 10.2142/biophys.41.S152_3 　

  84. Real-time memory on an excitable field Peer-reviewed

    Ikuko N. Motoike, Kenichi Yoshikawa, Yasutaka Iguchi, Satoshi Nakata

    Physical Review E - Statistical, Nonlinear, and Soft Matter Physics　63　(3)　362201-362204　2001

    DOI： 10.1103/PhysRevE.63.036220 　

    ISSN： 1539-3755

  85. Information Processing with connection of asymmetrical excitable fields

    Motoike I.N.

    Seibutsu Butsuri　40　S57　2000

    Publisher: The Biophysical Society of Japan General Incorporated Association

    DOI： 10.2142/biophys.40.S57_2 　

    ISSN： 0582-4052

  86. Information operations with an excitable field Peer-reviewed

    Ikuko Motoike, Kenichi Yoshikawa

    Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics　59　(5)　5354-5360　1999

    DOI： 10.1103/PhysRevE.59.5354 　

    ISSN： 1063-651X

  87. Logic operation on an excitable field Peer-reviewed

    Motoike, I, K Yoshikawa

    ICONIP'98: THE FIFTH INTERNATIONAL CONFERENCE ON NEURAL INFORMATION PROCESSING JOINTLY WITH JNNS'98: THE 1998 ANNUAL CONFERENCE OF THE JAPANESE NEURAL NETWORK SOCIETY - PROCEEDINGS, VOLS 1-3　720-722　1998

  88. Design of an excitable field towards a novel parallel computation

    K Yoshikawa, Motoike, I, K Kajiya

    IEICE TRANSACTIONS ON ELECTRONICS　E80C　(7)　931-934　1997/07

    ISSN： 0916-8524

    eISSN： 1745-1353

Show all ︎Show first 5

Misc. 56

  1. Circulating Metabolites Mediate the Association Between Polygenic Risk Score and Incident Hypertension

    Masato Takase, Naoki Nakaya, Eiji Hishinuma, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Kazuki Kumada, Ikuko Motoike, Seizo Koshiba, Atsushi Hozawa

    CIRCULATION　153　(SUPPL_1)　AWE463-AWE463　2026/03/24

    DOI： 10.1161/cir.153.suppl_1.WE463 　

    ISSN： 0009-7322

    eISSN： 1524-4539

  2. 上皮性卵巣癌組織検体を用いたショットガンプロテオーム解析

    大石真唯子, 菱沼英史, 菱沼英史, 島田宗昭, 島田宗昭, 島田宗昭, 松川直美, 佐藤直人, 村川東, 久木元詩央香, 栃木実佳子, 萩原達也, 吉泉絵理, 宮原周子, 工藤敬, 湊純子, 渋谷祐介, 石橋ますみ, 重田昌吾, 元池育子, 元池育子, 木下賢吾, 木下賢吾, 木下賢吾, 小柴生造, 小柴生造

    日本婦人科腫瘍学会学術講演会プログラム・抄録集(Web)　67th　2025

  3. 血漿メタボロームと糖尿病発症の関連および糖尿病の遺伝リスクの違いにおける血漿メタボロームの比較

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    日本疫学会学術総会講演集(Web)　35th　2025

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    佐藤和, 藤原和樹, 長尾健児, 今泉明, 小柴生造, 佐藤允治, 元池育子, 木下賢吾, 麦倉俊司, 山本雅之

    日本生化学会大会(Web)　97th　2024

  5. 東北メディカル・メガバンク計画 NMRを用いたコホートデータ解析

    寳澤篤, 寳澤篤, 小柴生造, 元池育子, 菱沼英史, 中谷久美, 中谷久美, 木内桜

    日本生化学会大会(Web)　97th　2024

  6. Genome-wide association study of central corneal thickness in the cohort Study

    布施昇男, 安澤隼人, 元池育子, 櫻井美由紀, 木下賢吾, 山本雅之

    日本眼科学会雑誌　128　2024

    ISSN： 0029-0203

  7. 重症喘息患者を対象とした全血網羅的遺伝子発現解析;好中球活性化の関与

    鈴木眞奈美, 山田充啓, 藤野直也, 吉良聡, 笠澄望, 元池育子, 元池育子, 上出庸介, 関谷潔史, 小林誠一, 佐藤輝幸, 松本周一郎, 小野祥直, 今野周一, 遠藤卓人, 玉田勉, 谷口正実, 勝岡史城, 木下賢吾, 杉浦久敏

    アレルギー　73　(6/7)　2024

    ISSN： 0021-4884

  8. 血漿メタボローム解析を用いた婦人科癌におけるバイオマーカーの探索

    菱沼英史, 菱沼英史, 島田宗昭, 島田宗昭, 島田宗昭, 松川直美, 萩原達也, 工藤敬, 渋谷祐介, 重田昌吾, 元池育子, 元池育子, 徳永英樹, 徳永英樹, 木下賢吾, 木下賢吾, 木下賢吾, 小柴生造, 小柴生造, 八重樫伸生, 八重樫伸生, 八重樫伸生

    日本婦人科腫瘍学会学術講演会プログラム・抄録集(Web)　66th　2024

  9. 日本人集団における食習慣と血漿中脂質濃度の関連解析

    佐藤 允治, 菱沼 英史, 三枝 大輔, 元池 育子, 木下 賢吾, 小柴 生造

    脂質生化学研究　65　291-292　2023/05

    Publisher: 日本脂質生化学会

    ISSN： 0285-1520

  10. ツイート頻度系列に基づく休息-活動リズムの大規模・グローバル解析

    中尾光之, 中尾光之, 高橋容市, 辛島彰洋, 元池育子, 片山統裕, 木下賢吾, 木下賢吾, 乾健太郎, 乾健太郎

    日本睡眠学会定期学術集会プログラム・抄録集　45th　2023

  11. Inspection of metabolome-GWAS with metabolic pathway simulations

    小舘俊, 小舘俊, 佐藤允治, 元池育子, 木下賢吾

    日本分子生物学会年会プログラム・要旨集(Web)　46th　2023

  12. 海馬周辺の脳容積値と関連する血中メタボロームの探索

    佐藤和, 藤原和樹, 長尾健児, 今泉明, 小柴生造, 佐藤允治, 元池育子, 木下賢吾, 山本雅之

    Dementia Japan　37　(4)　2023

    ISSN： 1342-646X

  13. 血中代謝プロファイルに遺伝・環境要因が与える影響の解析

    小柴生造, 小柴生造, 元池育子, 元池育子, 菱沼英史, 菱沼英史, 青木裕一, 櫻井美由紀, 佐藤允治, 七谷圭, 七谷圭, 田高周, 木下賢吾, 木下賢吾, 木下賢吾, 山本雅之, 山本雅之, 山本雅之

    日本生化学会大会(Web)　96th　2023

  14. 日本人成人GWASによる肺機能・FeNO関連遺伝子の同定

    山田 充啓, 元池 育子, 小島 要, 光根 歩, 大江 崇, 一ノ瀬 正和, 山本 雅之, 杉浦 久敏

    日本呼吸器学会誌　11　(増刊)　129-129　2022/04

    Publisher: (一社)日本呼吸器学会

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    eISSN： 2186-5884

  15. 東北メディカル・メガバンク計画健康調査における眼軸長のゲノムワイド関連解析

    布施 昇男, 櫻井 美由紀, 元池 育子, 小島 要, 平良 摩紀子, 宇留野 晃, 濱中 洋平, 中村 智洋, 荻島 創一, 寳澤 篤, 栗山 進一, 呉 繁夫, 木下 賢吾, 山本 雅之

    日本眼科学会雑誌　126　(臨増)　216-216　2022/03

    Publisher: (公財)日本眼科学会

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  16. Publisher Correction: Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers. International-journal

    Keito Okazaki, Hayato Anzawa, Zun Liu, Nao Ota, Hiroshi Kitamura, Yoshiaki Onodera, Md Morshedul Alam, Daisuke Matsumaru, Takuma Suzuki, Fumiki Katsuoka, Shu Tadaka, Ikuko Motoike, Mika Watanabe, Kazuki Hayasaka, Akira Sakurada, Yoshinori Okada, Masayuki Yamamoto, Takashi Suzuki, Kengo Kinoshita, Hiroki Sekine, Hozumi Motohashi

    Nature communications　12　(1)　506-506　2021/01/15

    DOI： 10.1038/s41467-021-20927-9 　

  17. Comprehensive Characterization of Sleep and Physiological Conditions and Its Relationship with Dietary Habits

    鈴木圭介, CHOILEK Siawlee, 元池育子, 元池育子, 辛島彰洋, 辛島彰洋, 片山統裕, 片山統裕, 中尾光之

    電子情報通信学会技術研究報告(Web)　121　(222(MBE2021 17-25))　2021

    ISSN： 2432-6380

  18. 代謝プロファイルに影響を与える遺伝要因の網羅的解析

    小柴生造, 小柴生造, 小柴生造, 元池育子, 元池育子, 三枝大輔, 三枝大輔, 井上仁, 井上仁, 井上仁, 菱沼英史, 青木裕一, 青木裕一, 田高周, 田高周, 城田松之, 城田松之, 城田松之, 木下賢吾, 木下賢吾, 木下賢吾, 山本雅之, 山本雅之, 山本雅之

    日本生化学会大会(Web)　94th　2021

  19. Is Sticking to Highly Regular Sleep/Wake Timing Good for Health?-A quantitative study of associations between sleep/wake habit, objective sleep-related parameters, and subjective sleep quality-

    CHOILEK Siwalee, MOTOIKE Ikuko N., UCHIBAYASHI Toshihiro, KARASHIMA Akihiro, KARASHIMA Akihiro, KATAYAMA Norihiro, NAKAO Mitsuyuki

    電子情報通信学会技術研究報告　119　(224(MBE2019 29-44)(Web))　2019

    ISSN： 0913-5685

  20. Metabolome Analysis of Human Plasma by GC-MS/MS in a Large-scale Cohort

    三枝大輔, 三枝大輔, 松川直美, 松川直美, 田高周, 田高周, 元池育子, 元池育子, 小柴生造, 小柴生造

    日本プロテオーム学会誌(Web)　4　(1)　2019

    ISSN： 2432-2776

  21. ゲノミクスを基盤とした生活習慣病解析最前線 ゲノム情報と連携した日本人多層オミックス参照パネルの意義

    小柴 生造, 元池 育子, 三枝 大輔, 井上 仁, 城田 松之, 青木 裕一, 田高 周, 斎藤 智, 木下 賢吾, 山本 雅之

    糖尿病　61　(Suppl.1)　S-48　2018/04

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

    eISSN： 1881-588X

  22. Estimating frequency of pathogenic variants in a Japanese population by using the whole-genome reference panel of ToMMo

    Yumi Yamaguchi-Kabata, Jun Yasuda, Osamu Tanabe, Yoichi Suzuki, Hiroshi Kawame, Nobuo Fuse, Masao Nagasaki, Yosuke Kawai, Kaname Kojima, Fumiki Katsuoka, Sakae Saito, Inaho Danjoh, Ikuko N. Motoike, Riu Yamashita, Seizo Koshiba, Daisuke Saigusa, Gen Tamiya, Shigeo Kure, Nobuo Yaegashi, Yoshio Kawaguchi, Fuji Nagami, Shinichi Kuriyama, Junichi Sugawara, Naoko Minegishi, Atsushi Hozawa, Soichi Ogishima, Hideyasu Kiyomoto, Takako Takai-Igarashi, Kengo Kinoshita, Masayuki Yamamoto

    HUMAN GENOMICS　12　2018/03

    ISSN： 1473-9542

    eISSN： 1479-7364

  23. 他分野の基礎研究から学ぶ最先端研究 メタボローム解析を応用した個別化医療

    三枝 大輔, 佐藤 孝太, 齋藤 律水, 元池 育子, 中澤 徹, 山本 雅之

    日本眼科学会雑誌　122　(臨増)　30-30　2018/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  24. Selected Sleep-Wake Lifestyle Differentiates Relationship between Dynamics of Activity and Variabilities of Physiological Rhythms

    天野領太, 辛島彰洋, 辛島彰洋, 元池育子, 片山統裕, 木下賢吾, 木下賢吾, 中尾光之

    電子情報通信学会技術研究報告　118　(257(MBE2018 27-35)(Web))　2018

    ISSN： 0913-5685

  25. State-dependent HRV dynamics and their correlations with subjective sleep quality

    AMANO RYOTA, KARASHIMA AKIHIRO, MOTOIKE IKUKO, KATAYAMA NORIHIRO, KINOSHITA KENGO, NAKAO MITSUYUKI

    Transactions of Japanese Society for Medical and Biological Engineering　Annual56　(Abstract)　S331-S331　2018

    Publisher: Japanese Society for Medical and Biological Engineering

    DOI： 10.11239/jsmbe.annual56.s331 　

    ISSN： 1347-443X

    eISSN： 1881-4379

    More details Close

    Appropriate characterization of state-dependent Heart Rate Variability Dynamics (HRVD) has been explored.We analyzed the difference between state-dependent HRVD and the HRVD of Slow Wave Sleep (SWS: the deepest sleep), together with subjective sleep evaluation. The results showed that the subjective sleep evaluation differentiates the relationship between the state-dependent HRVD with reference to those in SWS. A future study will be further investigation of sleep quality and dynamics of cardiovascular control system.

  26. 視神経挫滅モデル網膜のメタボローム解析

    佐藤孝太, 三枝大輔, 元池育子, 齋藤律水, 藤岡周, 山本雅之, 中澤徹

    日本緑内障学会抄録集　29th　2018

  27. ゲノム情報と連携した日本人多層オミックス参照パネルの意義

    小柴生造, 小柴生造, 元池育子, 元池育子, 三枝大輔, 三枝大輔, 井上仁, 井上仁, 城田松之, 城田松之, 青木裕一, 青木裕一, 田高周, 田高周, 斎藤智, 木下賢吾, 木下賢吾, 山本雅之, 山本雅之

    糖尿病(Web)　61　(Suppl)　2018

    ISSN： 1881-588X

  28. 質量分析計を用いる大規模メタボローム解析におけるデータ補正について

    三枝大輔, 三枝大輔, 三枝大輔, 元池育子, 元池育子, 小柴生造, 小柴生造

    質量分析総合討論会講演要旨集　65th　2017

  29. メタボロミクス解析を用いたサルコイドーシスの活動性予測バイオマーカーの検索

    蒲生俊一, 玉田勉, 村上康司, 三枝大輔, 元池育子, 有竹秀美, 奈良正之, 村松聡士, 村松聡士, 杉浦久敏, 一ノ瀬正和

    日本サルコイドーシス/肉芽腫性疾患学会雑誌　37　2017

    ISSN： 1883-1273

  30. マルチオミクスが解き明かす疾患生物学 日本人多層オミックス参照パネルの拡張

    小柴 生造, 三枝 大輔, 元池 育子, 小島 要, 城田 松之, 齋藤 智, 勝岡 史城, 河合 洋介, 山口 由美, 田邉 修, 長崎 正郎, 安田 純, 木下 賢吾, 山本 雅之

    日本生化学会大会プログラム・講演要旨集　89回　[1S05-5]　2016/09

    Publisher: (公社)日本生化学会

  31. Plasma Proteomics Study in the Tohoku Medical Megabank Organization

    Shirota Matsuyuki, Katoh Yasutake, Ikuko Motoike, Kinoshita Kengo, Koshiba Seizo

    Abstracts for Annual Meeting of Japanese Proteomics Society　2016　98-98　2016

    Publisher: Japanese Proteomics Society (Japan Human Proteome Organisation)

    DOI： 10.14889/jhupo.2016.0.98.0 　

  32. 大規模コホートにおけるトランスオミクス解析

    三枝大輔, 三枝大輔, 三枝大輔, 元池育子, 元池育子, 小柴生造, 小柴生造

    日本プロテオーム学会大会プログラム・抄録集　2016　2016

  33. 日本人多層オミックス参照パネルの公開

    小柴生造, 加藤恭丈, 三枝大輔, 元池育子, 城田松之, 斎藤智, 田邉修, 安田純, 木下賢吾, 山本雅之

    日本生化学会大会(Web)　88th　4T21L-07(3P0816) (WEB ONLY)-07(3P0816)]　2015/12

    Publisher: (公社)日本生化学会

  34. LC‐MSによる大規模コホートメタボローム解析

    三枝大輔, 加藤恭丈, 小柴生造, 元池育子, 荻島創一, 本橋ほづみ, 菅原準一, 中谷純, 寳澤篤, 峯岸直子, 木下賢吾, 田邉修, 山本雅之

    日本農芸化学会大会講演要旨集(Web)　2015　4SY19-2 (WEB ONLY)　2015/03/05

    ISSN： 2186-7976

  35. Plasma proteome analysis for a large-scale population-based cohort study

    Katoh Yasutake, Koshiba Seizo, Igarashi Kazuhiko, Yamamoto Masayuki, Tanabe Osamu, Ebina Masayuki, Shirota Matsuyuki, Motoike Ikuko, Kinoshita Kengo, Kudo Hisaaki, Nobukuni Takahiro, Minegishi Naoko, Saigusa Daisuke

    Abstracts for Annual Meeting of Japanese Proteomics Society　2015　(0)　62-62　2015

    Publisher: Japanese Proteomics Society (Japan Human Proteome Organisation)

    DOI： 10.14889/jhupo.2015.0.62.0 　

  36. Erratum: Global genetic response in a cancer cell: Self-organized coherent expression dynamics (PLoS ONE (2014) 9, 5, (e97411) DOI:10.1371/journal.pone. 0097411) Peer-reviewed

    M. Tsuchiya, M. Hashimoto, Y. Takenaka, I. N. Motoike, K. Yoshikawa

    PLoS ONE　9　(8)　2014/08/08

    DOI： 10.1371/journal.pone.0105491 　

    ISSN： 1932-6203

    eISSN： 1932-6203

  37. Global Genetic Response in a Cancer Cell: Self-Organized Coherent Expression Dynamics (vol 9, e97411, 2014)

    M. Tsuchiya, M. Hashimoto, Y. Takenaka, I. N. Motoike, K. Yoshikawa

    PLOS ONE　9　(8)　2014/08

    DOI： 10.1371/journal.pone.0105491 　

    ISSN： 1932-6203

  38. 眼疾患と遺伝子 緑内障のゲノム解析 次世代医療・個別化医療に向けて

    布施 昇男, 清水 愛, 木村 雅恵, 高野 良真, 石 棟, 宮澤 晃子, 国松 志保, 劉 孟林, 渡邉 亮, 安田 正幸, 横山 悠, 檜森 紀子, 津田 聡, 山本 耕太郎, 中澤 徹, 安田 純, 勝岡 史城, 小島 要, 成相 直樹, 松本 光代, 元池 育子, 長崎 正朗, 木下 賢吾, 五十嵐 和彦, 山本 雅之, 新堀 哲也, 青木 洋子, 松原 洋一, 舟山 亮, 長嶋 剛史, 中山 啓子, 眞島 行彦, 船山 智代, 田中 光一, 原田 高幸, 阿部 春樹, 福地 健郎, 安田 典子, 出田 秀尚, 鄭 暁東, 白石 敦, 大橋 裕一, 石田 誠夫, 原 岳, 金森 章泰, 山田 裕子, 中村 誠, 酒井 寛, Richards Julia E

    日本眼科学会雑誌　118　(3)　216-240　2014/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  39. 24pPSB-13 Pattern formation in a couple of dendritic paths correlated with a history of signal propagation

    Motoike N. Ikuko, Takigawa-Imamura Hisako

    Meeting abstracts of the Physical Society of Japan　65　(2)　260-260　2010/08/18

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  40. 樹状形状に依存した演算機能の解析

    今村(滝川)寿子, 元池N.育子, 元池N.育子

    日本数理生物学会大会講演要旨集　20th　2010

  41. Signal Processing with Pulses of Excitation(<Special Issue>A Spectrum of Dynamics-Based Information Processing)

    MOTOIKE Ikuko N.

    SYSTEMS, CONTROL AND INFORMATION　54　(1)　3-8　2010

    Publisher: THE INSTITUTE OF SYSTEMS, CONTROL AND INFORMATION ENGINEERS

    DOI： 10.11509/isciesci.54.1_3 　

    ISSN： 0916-1600

    eISSN： 2424-1806

  42. 29pPSB-31 Spatial Pattern Formation on Two-layer Resistive Sheets : Experiments for DoE Diffusion

    Suzuki Yoh-hey, Motoike Ikuko N., Asai Tetsuya

    Meeting abstracts of the Physical Society of Japan　61　(1)　316-316　2006/03/04

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  43. 22aPS-13 Spacial Pattern Formation on Diffusive Lotka-Volterra Analog LSIs

    Kamiya Taishi, Motoike Ikuko N., Asai Tetsuya

    Meeting abstracts of the Physical Society of Japan　60　(2)　204-204　2005/08/19

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  44. 22aPS-14 A Mechanism for Spatial Pattern Formation on Two-layer Resistive Sheets

    Suzuki Yohei, Motoike Ikuko N., Asai Tetsuya

    Meeting abstracts of the Physical Society of Japan　60　(2)　204-204　2005/08/19

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  45. A Simple Reaction-Diffusion Cellular Automaton Model generating Turing Patterns and its LSI Implementation for Restoring Stripe and Spot Images

    SUZUKI Yohei, TAKAYAMA Takahiro, N. MOTOIKE Ikuko, ASAI Tetsuya

    IEICE technical report. Nonlinear problems　104　(753)　29-34　2005/03/18

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

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    In this report, we propose a novel RD model that repairs Turing patterns; e.g., stripe and spot patterns observed in human fingerprints and marking patterns on various animals. Based on the model, we propose a novel LSI architecture, aiming at the development of compact and low-power silicon RD systems. By extensive circuit simulations, we confirmed that the proposed LSI could restore stripe and spot images within 10, 000 clock cycles, independently of the number of pixels in the image.

  46. Spontaneous Formation of Giant Liposome Network

    Nomura S.-i.M., Motoike I.N., Akiyoshi K.

    Seibutsu Butsuri　43　(0)　S110　2003

    Publisher: The Biophysical Society of Japan General Incorporated Association

    DOI： 10.2142/biophys.43.S110_3 　

    ISSN： 0582-4052

  47. Simple Information Operation Depends on Geometry

    MOTOIKE N. Ikuko

    Seibutsu Butsuri　43　(2)　81-86　2003

    Publisher: The Biophysical Society of Japan General Incorporated Association

    DOI： 10.2142/biophys.43.81 　

    ISSN： 0582-4052 1347-4219

    eISSN： 1347-4219

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    In living organisms, signals propagate through various kinds of geometrical or boundary paths. It is well established that a traveling wave can be generated on an excitable field; this generation is described by reaction-diffusion equations for an activator and inhibitor. I use a numerical simulation to show that the signaling pulse can be transmitted from an excitable field to an opposing excitable field via an intervening passive diffusion field in a characteristic manner that depends upon the spatial geometry of the excitable fields. Using such characteristics, it is possible to design various kinds of simple information operations.

  48. 場の幾何学的形状に依存する興奮波伝播パターンと情報処理

    元池育子

    数理解析研究所講究録　1313　47-52　2003

    Publisher: 京都大学数理解析研究所

    ISSN： 1880-2818

  49. 反応拡散場の非対称結合系での情報処理演算の試み (反応拡散系 : 生物・化学における現象とモデル)

    元池, N.育子

    数理解析研究所講究録　1167　25-26　2000/08

    Publisher: 京都大学数理解析研究所

    ISSN： 1880-2818

  50. 対称性の破れが創りだす美

    元池育子

    化学　4　1999

  51. Information Processing on an Excitable Field

    Yoshikawa Kenichi, Motoike Ikuko

    Proceedings of the Society Conference of IEICE　1998　(2)　182-183　1998/09/07

    Publisher: The Institute of Electronics, Information and Communication Engineers

  52. Informational Processing on an Excitable Field

    MOTOIKE Ikuko, YOSHIKAWA Kenichi

    Meeting abstracts of the Physical Society of Japan　53　(2)　734-734　1998/09/05

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  53. 興奮場の特質を用いた情報処理演算

    Motoike, Ikuko

    70　(3)　413-415　1998/06/20

    Publisher: 物性研究刊行会

    ISSN： 0525-2997

  54. Logic operation with Excitable Field

    MOTOIKE I., YOSHIKAWA K.

    Meeting abstracts of the Physical Society of Japan　53　(1)　643-643　1998/03/10

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  55. 6a-YD-9 Computation with Excitable Pulses in Spatially Anisotropic Field

    Motoike I., Yoshikawa K.

    Meeting abstracts of the Physical Society of Japan　52　(2)　745-745　1997/09/16

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  56. 31a-PS-42 Signal Processing on an Excitable Field

    Motoike I., Yoshikawa K.

    Meeting abstracts of the Physical Society of Japan　52　(1)　741-741　1997/03/17

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

Show all ︎Show first 5

Books and Other Publications 2

  1. ニューロンのダイナミクスと情報処理

    脳のフィジックス (長谷川建治・吉岡亨編, 共立出版)　2004

  2. Simple Signal Processing Depends on the Geometry of the Medium

    Chemical Analysis Based on Nonlinearity (ed. by Satoshi Nakata, Nova Science Pub Inc Published)　2003

Presentations 9

  1. 日本人集団における食習慣と血漿中脂質濃度の関連解析

    佐藤 允治, 菱沼 英史, 三枝 大輔, 元池 育子, 木下 賢吾, 小柴 生造

    脂質生化学研究　2023/05

  2. 血清メタボロームと認知機能変化の関連 NILS-LSAの観察結果から

    寳澤 篤, 大塚 礼, 張 シュ, 菱沼 英史, 元池 育子, 三枝 大輔, 中谷 直樹, 小柴 生造, 荒井 秀典

    Journal of Epidemiology　2023/02

  3. 遺伝・生活習慣が日本人の血中代謝プロファイルに与える影響の解析

    小柴 生造, 元池 育子, 井上 仁, 菱沼 英史, 青木 裕一, 櫻井 美由紀, 佐藤 允治, 七谷 圭, 田高 周, 城田 松之, 木下 賢吾, 山本 雅之

    日本生化学会大会プログラム・講演要旨集　2022/11

  4. jMorp: Japanese Multi Omics Reference Panel

    田高 周, 菱沼 英史, 井上 仁, 青木 裕一, 岡村 容伸, 川嶋 順子, 大槻 晃史, 田口 恵子, 菅野 貴成, 元池 育子, 勝岡 史城, 小柴 生造, 木下 賢吾

    トーゴーの日2022　2022/10/05

  5. 代謝プロファイルに影響を与える遺伝要因の網羅的解析

    小柴 生造, 元池 育子, 三枝 大輔, 井上 仁, 菱沼 英史, 青木 裕一, 田高 周, 城田 松之, 木下 賢吾, 山本 雅之

    日本生化学会大会プログラム・講演要旨集　2021/11

  6. 血漿メタボロームと頸動脈内膜中膜肥厚の関連

    寳澤 篤, 小柴 生造, 平田 匠, 中村 智洋, 土屋 菜歩, 成田 暁, 小暮 真奈, 元池 育子, 三枝 大輔, 峯岸 直子, 栗山 進一, 田宮 元, 辻 一郎, 木下 賢吾, 呉 繁夫

    日本高血圧学会総会プログラム・抄録集　2019/10

  7. コホート調査における代謝プロファイルの経時変化の解析

    小柴 生造, 元池 育子, 三枝 大輔, 井上 仁, 菱沼 英史, 青木 裕一, 田 高周, 城田 松之, 木下 賢吾, 山本 雅之

    日本生化学会大会プログラム・講演要旨集　2019/09

  8. メタボロームGWASによる日本人の代謝プロファイルの解析

    小柴 生造, 元池 育子, 三枝 大輔, 井上 仁, 青木 裕一, 田高 周, 城田 松之, 木下 賢吾, 山本 雅之

    日本生化学会大会プログラム・講演要旨集　2018/09

  9. 高精度日本人多層オミックス参照パネルの提供

    小柴 生造, 元池 育子, 三枝 大輔, 井上 仁, 城田 松之, 斎藤 智, 木下 賢吾, 山本 雅之

    生命科学系学会合同年次大会　2017/12

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Research Projects 16

  1. 尿毒素-超硫黄代謝異常を基軸とした高齢慢性腎臓病合併症の治療開発

    佐藤 恵美子, 有村 奈利子, 吉田 舞, 元池 育子, 田中 哲洋, 三枝 大輔

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2026/04/01 - 2030/03/31

  2. 尿毒素による細胞内代謝失調を標的とした高齢者の慢性腎臓病合併症の治療開発

    佐藤 恵美子, 吉田 舞, 山越 聖子, 宮崎 真理子, 元池 育子, 田中 哲洋, 三枝 大輔

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2023/04/01 - 2027/03/31

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    本研究では高齢CKD合併の認知機能障害・サルコペニアにおける尿毒素誘導-細胞内代謝変化を創薬標的とした治療有用性を明らかにし、この機序に基づくCKD合併症の病態バイオマーカーの確立と包括的な予防・治療法の開発をすることを目的として研究を進めている。今年度は、CKD病態に則した代謝変化を明らかにするため、透析患者のヒト血清を細胞に直接添加することで代謝変化を評価し、CKD合併病態の細胞内代謝失調を反映する代謝物バイオマーカーの探索を行った。CKD stage1とCKD stage5の患者血清を用いてC2C12細胞株における代謝変化をGC-MSによるメタボロミクス解析から評価した結果、CKDの重症化により筋細胞内の代謝が変化することを明らかにした。腎機能の低下で血中に蓄積する物質が、筋細胞内の代謝を変化させることを明らかにした。さらに、実臨床に近い病態の解析のために、C57BL/6Jマウスのオス若年齢(8週)とオス中年齢(25週齢)のマウスを用いて、腎不全モデルマウスを作製し、ヒラメ筋、腓腹筋、大腿四頭筋、前脛骨筋、長趾伸筋を採取し、それぞれの筋における代謝変化をGC-MSメタボロミクス解析にて評価した。その結果、若年齢と中年齢における筋での代謝は異なっていた。さらに、腎不全状態下における筋代謝の変化は、若年齢では速筋で、中年齢では遅筋で起こることを明らかにした。 これに加え、尿毒素が与える角化細胞に与える影響についても評価を行った。その結果、尿毒素は角化細胞の炎症・酸化ストレスを介して細胞増殖率やミトコンドリア機能を低下させ、細胞障害を引き起こすことが示唆された。

  3. 尿毒素による細胞内代謝失調を標的とした高齢者の慢性腎臓病合併症の治療開発

    佐藤 恵美子, 田中 哲洋, 宮崎 真理子, 元池 育子, 山越 聖子, 三枝 大輔, 吉田 舞

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2023/04/01 - 2027/03/31

  4. 紫外線感受性核酸多型に基づく尋常性白斑発症予測プログラムの構築

    山崎 研志, 小島 要, 元池 育子

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(C)

    Category: 基盤研究(C)

    Institution: 東北大学

    2022/04/01 - 2025/03/31

  5. Genome modality in germ cells and its implications in diseases

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Transformative Research Areas (A)

    Category: Grant-in-Aid for Transformative Research Areas (A)

    Institution: The University of Tokyo

    2020/11/19 - 2025/03/31

  6. Development of tree-dimensional MS imaging for sphingolipids

    Saigusa Daisuke

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2017/04/01 - 2020/03/31

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    Sphingolipids are bioactive lipid mediators related with the expression of cancer and immune disease and has been estimated the target molecules of drug discovery. Although their biological functions were reacted beside on the metabolism-related molecules on tissue, they could not be detected directly on the tissue section in previous studies. In this study, we demonstrated that the conductive adhesive film can overcome the setbacks of the MALDI-MSI approach by allowing the imaging of intact cryosections, such as the bone, muscle, adipose tissues and whole mouse body. We finally developed the on-tissue derivatization method for the detection of S1P on the cryosection and improved the ion intensities of sphingolipids by means of the MALDI-MSI analysis.

  7. Real-World Modeling on the Hierarchical Dynamics of Living System

    Yoshikawa Kenichi, TSUMOTO Kanta, MOTOIKE Ikuko, ICHIKAWA Masatoshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Doshisha University

    2011/04/01 - 2016/03/31

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    We studied the dynamical aspects of life accompanied by the development of physical consideration, by considering the hierarchical structure: 1) On-off switching of large number of genes embedded in genomic DNA. Biological significance of the discrete nature of the conformational transition was theoretically discussed in relation to robust on/off switching of large number of genes on the process of cell-differentiation. 2) Field hypothesis on living cell. It was shown that unique physic-chemical properties emerge in micro systems, which may concern with the life activity of living cells. 3)Novel non-Turing scenario of body-organization during development was proposed and simple theoretical modeling was successfully achieved.

  8. Actualization of the signal-processing function by path reforming in a complicated network-like signal propagation media

    MOTOIKE Ikuko

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2011 - 2013

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    The dendritic signal propagating path formation system was studied by using of the discrete dynamics model based on a reaction-diffusion system. In this system dendritic path expands or shrinks depending on a history of signal propagation on the path. In this study this shrinking aspects was focused on. The variety of patterns of dendritic path and signal propagation patterns were investigated. As an extension of this system three-dimensional dendritic signal propagation path formation system was described. In order to realize the dynamics in which path changes dynamically according to a signal propagation history, it is necessary that subtractive path reformation system with initial state of random network path connection, and it is important that adoption of a conservative quantity, like a source of path formation.

  9. Spiral Formation of Exc itation Waves Based on Curvature Effect in Culture of Cardiomyocyt

    MAGOME Nobuyuki, MOTOIKE Ikuko, IMAMURA Hisako, ORLOVA Yuliya

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Kyoto University

    2009 - 2012

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    Behaviors of traveling excitation waves around obstacle region in cultivated cardiomyocytes were investigated in experimentally and numerically. The instability of propagation waves were affected by excitability of the cells and shape of obstacle.Spontaneous formation of spiral wave at edge of sharp corner was also observed.Furthermore, new methods (1) to control activity of cardiomyocytes with the aid of photo-switching molecules, and (2) to construct aligned culture of cells along fabricated microfiber were established

  10. Towards Noise-driven Information Processing Systems for Nano-scale Molecular and Semiconductor Devices

    ASAI Tetsuya, OYA Takahide, MOTOIKE Ikuko, ADAMATZKY Andrew, SCHMID Alexndre

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

    Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

    Institution: Hokkaido University

    2008 - 2012

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    Aiming at the development of noise-driven information processing systems on possible nano-scale semiconductor devices, the following systems have been developed: (i) weak-signal detector based on stochastic resonance, (ii) an analog-to-digital converter that utilized noise and fluctuations, (iii) fast signal transmission utilizing mismatches of semiconductor devices, (iv) noise-induced phase synchronization among subthreshold CMOS oscillators, (v) ultra-low-power logic memory cells utilizing noise and fluctuations, and (vi) brain-inspired information processing circuits that utilized noises. Molecular devices for (i), (iii) and (v) have also been developed with group A04, and we could observe expected operations of the molecular devices for (i). For the rest items [(ii), (iv), and (v)], we evaluated the model on nano semiconductor devices, and could observe desired dynamical operations.

  11. 時間発展する樹状経路構造上の信号伝播様式

    元池 育子

    Offer Organization: 科学技術振興機構

    System: 戦略的な研究開発の推進 戦略的創造研究推進事業 さきがけ

    Institution: はこだて未来大学

    2007 - 2011

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    信号処理素子である神経細胞や、粘菌の管などは、枝分かれした樹状という特徴的な「形」をしています。そしてこの形は、信号の伝播に応じて、少しずつ変わっていきます。この「形」をとることによるメリットは何なのか、単純化した数理モデルを用いて、樹状を走る信号のパターンから機能を読み取り、明らかにしていきます。発展として、樹状の結合系についても検証し、形と機能の関係から、生命の信号処理の基盤にアプローチします。

  12. Signal propagation on deformable patterns with reaction-diffusion system

    MOTOIKE Ikuko

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Kyoto University

    2008 - 2010

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    Discrete pattern formation model of splitting spot that reflect the history of signal propagation was proposed as a description of time variable local pattern. The splitting spot moves isotropic in the condition that growth factor for spot generation is supplied constantly at suitable rate. As for signal propagation, uni-directional signal propagation, signal failure, filtering of plural signals, and autonomous recursive signal generation were observed depending on media's shape. It was shown that signal fusion and Boolean operation including time-information can be realized utilizing above signaling features,

  13. 興奮特性をもつ信号媒体の分岐/樹状空間構造を活用した信号処理機能

    元池 育子

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 若手研究(B)

    Category: 若手研究(B)

    Institution: 公立はこだて未来大学

    2004 - 2005

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    本研究は、細胞内経路における信号の符号化の由来として、神経細胞一般にみられる2つの特性、信号発生・伝播の「興奮特性」と、複雑な信号伝播経路形状「分岐/樹状構造」に着目し、興奮特性をもつ場(信号伝播媒体)が分岐・樹状構造をとることによってどのような信号処理機能が得られ得るのかの解明の端につくことを目的としている。 上記の目的のため、前年度は樹状形状形成のシンプルなダイナミクス提案とその形状特性の同定、及び信号伝播特性の多様性について見出した。本年度は、よりシンプルな樹状形成のダイナミクス同定と、信号伝播と経路形成の2種のダイナミクスが相互作用を行う系での形成形状と信号伝播パターンの変化について、フラクタル次元やパターン成長速度等の解析を行い、生成規則パラメータの形成パターンに及ぼす影響、樹状枝密度の違いなどを明らかにした。 結果として、信号伝播が経路形成に正の影響を及ぼす場合には、及ぼさない場合に比べ、形成された経路形状の樹状枝の密度、曲がりくねり具合など、形状の定量的な変化は見られたが、大きな定性的な変化は見られなかった。また信号伝播が経路形成に正負両方の影響を及ぼす場合には、経路形状特性による螺旋波の発生の有無、信号の伝播パターンによって、パラメータによってはダイナミックな経路形状の変化が見られた。これらは、樹状経路上で見られる、情報処理機構の基盤となる単方向信号伝播(ダイオード特性)やペースメーカーの役割も果たす螺旋波発生機構と合わせ、信号伝播パターンの多様性による信号伝播経路形状に対する学習に似た効果を示唆していると考えられる。

  14. 興奮場の結合の非対称性を活用した並列・時間情報演算に関する研究

    元池 育子

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 特別研究員奨励費

    Category: 特別研究員奨励費

    Institution: 京都大学

    2000 - 2001

  15. 信号伝播媒体の形状特性を用いた信号処理モデル Competitive

  16. signal processing by utilizing geometrical features of signal propagation media Competitive

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