Details of the Researcher

PHOTO

Nobuko Kawakami
Section
Graduate School of Medicine
Job title
Assistant Professor
Degree

  • 博士（医学）（東北大学）

e-Rad No.
90817131

Research Interests 4

  • 認知症

  • 原発性進行性失語

  • 高次脳機能障害学

  • 神経心理学

Research Areas 1

  • Life sciences / Neurology /

Papers 25

  1. Distinct cerebral perfusion patterns and linguistic profiles in Alzheimer’s disease-related primary progressive aphasia

    Kazuto Katsuse, Kazuo Kakinuma, Nobuko Kawakami, Shoko Ota, Nanayo Ogawa, Ai Kawamura, Chifumi Iseki, Masashi Hamada, Tatsushi Toda, Minoru Matsuda, Shigenori Kanno, Kyoko Suzuki

    Neurological Sciences　2025/03/24

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s10072-025-08100-2 　

    ISSN： 1590-1874

    eISSN： 1590-3478

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    Abstract Alzheimer’s disease (AD)-related primary progressive aphasia (PPA) exhibits considerable heterogeneity in clinical presentation and neuroimaging patterns. No studies have quantitatively assessed cerebral perfusion patterns or systematically evaluated the internal heterogeneity of linguistic and neuroimaging features in this population. This study aimed to investigate cerebral hypoperfusion patterns and elucidate their correlation with diverse linguistic features in patients with AD-related PPA using a data-driven approach. Eleven patients with AD-related PPA and 34 with non-AD-related PPA were categorized based on cerebrospinal fluid biomarkers, and their single-photon emission computed tomography (SPECT) data were analyzed. Cerebral hypoperfusion was assessed across 56 regions of interest (ROIs) covering the entire cerebral hemisphere. Sparse principal component (sPC) analysis was performed on the AD-related PPA group to identify distinct patterns of cerebral perfusion reduction and correlate these components with clinical assessments of linguistic abilities. AD-derived sPCs were identified, reflecting hypoperfusion patterns in the left temporoparietal, frontal, and temporal pole regions, corresponding to regions typically associated with logopenic, nonfluent, and semantic variants. In both AD-PPA and non-AD-PPA, the sPC corresponding to the anterior temporal region was associated with semantic comprehension deficits, whereas that corresponding to the frontal region was linked to nonfluent speech and Kana writing impairment. sPC-based hierarchical clustering revealed clusters corresponding to logopenic, nonfluent, and semantic variants, with the anomic subtype distinguished from logopenic PPA. AD-positive cases were distributed across these clusters, emphasizing AD-PPA heterogeneity. These findings suggested that AD-related PPA heterogeneity is reflected in distinct cerebral perfusion patterns, which correlate with varying linguistic deficits.

  2. The utility of customised tissue probability maps and templates for patients with idiopathic normal pressure hydrocephalus: a computational anatomy toolbox (CAT12) study. International-journal

    Shigenori Kanno, Junyan Liu, Ai Kawamura, Shoko Ota, Nobuko Kawakami, Chifumi Iseki, Kazuo Kakinuma, Shiho Matsubara, Kazuto Katsuse, Kazushi Sato, Takashi Takeuchi, Yoshitaka Tanaka, Hiroyasu Kodama, Tatsuo Nagasaka, Masahiro Sai, Hayato Odagiri, Mioko Saito, Kentaro Takanami, Shunji Mugikura, Kyoko Suzuki

    Fluids and barriers of the CNS　21　(1)　108-108　2024/12/30

    DOI： 10.1186/s12987-024-00611-y 　

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    BACKGROUND: Disproportionately enlarged subarachnoid space hydrocephalus (DESH) is one of the neuroradiological characteristics of idiopathic normal pressure hydrocephalus (iNPH), which makes statistical analyses of brain images difficult. This study aimed to develop and validate methods of accurate brain segmentation and spatial normalisation in patients with DESH by using the Computational Anatomy Toolbox (CAT12). METHODS: Two hundred ninety-eight iNPH patients with DESH and 25 healthy controls (HCs) who underwent cranial MRI were enrolled in this study. We selected the structural images of 169 patients to create customised tissue probability maps and diffeomorphic anatomical registration through exponentiated Lie algebra (DARTEL) templates for patients with DESH (DESH-TPM and DESH-Template). The structural images of 38 other patients were used to evaluate the validity of the DESH-TPM and DESH-Template. DESH-TPM and DESH-Template were created using the 114 well-segmented images after the segmentation processing of CAT12. In the validation study, we compared the accuracy of brain segmentation and spatial normalisation among three conditions: customised condition, applying DESH-TPM and DESH-Template to CAT12 and patient images; standard condition, applying the default setting of CAT12 to patient images; and reference condition, applying the default setting of CAT12 to HC images. RESULTS: In the validation study, we identified three error types during segmentation. (1) The proportions of misidentifying the dura and/or extradural structures as brain structures in the customised, standard, and reference conditions were 10.5%, 44.7%, and 13.6%, respectively; (2) the failure rates of white matter hypointensity (WMH) cancellation in the customised, standard, and reference conditions were 18.4%, 44.7%, and 0%, respectively; and (3) the proportions of cerebrospinal fluid (CSF)-image deficits in the customised, standard, and reference conditions were 97.4%, 84.2%, and 28%, respectively. The spatial normalisation accuracy of grey and white matter images in the customised condition was the highest among the three conditions, especially in terms of superior convexity. CONCLUSIONS: Applying the combination of the DESH-TPM and DESH-Template to CAT12 could improve the accuracy of grey and white matter segmentation and spatial normalisation in patients with DESH. However, this combination could not improve the CSF segmentation accuracy. Another approach is needed to overcome this challenge.

  3. Oral applause sign in progressive supranuclear palsy. International-journal

    Kazuto Katsuse, Kazuo Kakinuma, Nobuko Kawakami, Shoko Ota, Ai Kawamura, Nanayo Ogawa, Chifumi Iseki, Masashi Hamada, Tatsushi Toda, Shigenori Kanno, Minoru Matsuda, Kyoko Suzuki

    Cortex; a journal devoted to the study of the nervous system and behavior　2024/12/27

    DOI： 10.1016/j.cortex.2024.11.021 　

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    The applause sign (AS) is a recognized phenomenon observed in progressive supranuclear palsy (PSP) and other neurological conditions where individuals produce over three claps following a request to clap only thrice after a demonstration. In this study, we introduced a novel linguistic phenomenon termed the oral applause sign (OAS) associated with the AS. The OAS is characterized by increased repetition counts of Japanese repetitive onomatopoeic words, such as uttering "pata-pata-pata" instead of the expected "pata-pata." We identified this phenomenon in a patient with PSP exhibiting the AS and mild apraxia of speech. In addition, we developed the three-"pata" test, instructing the patient to say "pata" only thrice after demonstration without any semantic context, and reproduced the phenomenon of the additional increase of "pata" verbalization. The core feature of OAS is an inability to limit the count when repeating a small number of syllables continuously, similar to the inability to stop clapping. The shared features between the OAS and AS suggest potential overlapping mechanisms involving the dysfunction of the frontal lobe and subcortical structures and possibly, apraxia of speech. Considering that the OAS is triggered purely by repetition and unlikely to be affected by semantic content, it might be observable in Japanese and other languages. Longitudinal studies with larger cohorts across various neurodegenerative diseases and languages may elucidate the underlying mechanisms of the OAS and confirm its specificity to PSP, thus improving the generalizability and clinical relevance of the findings.

  4. 肢節運動失行があってもactive touchでは手指の動きに拙劣さを認めなかった大脳皮質基底核症候群の1例

    小川 七世, 松原 史歩, 伊関 千書, 勝瀬 一登, 齋藤 治仁, 川村 藍, 川上 暢子, 柿沼 一雄, 菅野 重範, 鈴木 匡子

    日本神経心理学会総会プログラム・予稿集　48回　110-110　2024/08

    Publisher: 日本神経心理学会

  5. 半盲視野に人物の複雑幻視を生じた左後頭葉梗塞の一例

    柿沼 一雄, 勝瀬 一登, 松原 史歩, 菊地 花, 齋藤 治仁, 太田 祥子, 川上 暢子, 伊関 千書, 菅野 重範, 鈴木 匡子

    日本神経心理学会総会プログラム・予稿集　48回　116-116　2024/08

    Publisher: 日本神経心理学会

  6. A decade with anomic primary progressive aphasia

    Shoko Ota, Kazuo Kakinuma, Wataru Narita, Yoshiyuki Nishio, Nobuko Kawakami, Ayane Tamagake, Shigenori Kanno, Minoru Matsuda, Kyoko Suzuki

    eNeurologicalSci　35　100508-100508　2024/06

    Publisher: Elsevier BV

    DOI： 10.1016/j.ensci.2024.100508 　

    ISSN： 2405-6502

  7. The grasp reflex in patients with idiopathic normal pressure hydrocephalus. International-journal

    Junyan Liu, Shigenori Kanno, Chifumi Iseki, Nobuko Kawakami, Kazuo Kakinuma, Kazuto Katsuse, Shiho Matsubara, Shoko Ota, Keiko Endo, Kentaro Takanami, Shin-Ichiro Osawa, Tomohiro Kawaguchi, Hidenori Endo, Shunji Mugikura, Kyoko Suzuki

    Journal of neurology　2024/04/08

    DOI： 10.1007/s00415-024-12341-0 　

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    OBJECTIVE: To investigate the prevalence and intensity of grasp reflexes and to examine changes in these reflexes after shunt surgery in patients with idiopathic normal pressure hydrocephalus (iNPH). METHODS: We enrolled 147 patients with probable iNPH. A standard procedure was used to determine the presence of grasp reflexes, and the intensity of these reflexes was assessed using a four-category classification. Clinical rating scales and their correlation with grasp reflexes were also evaluated. Grasp reflexes were reassessed in 72 patients 1 year after surgery. RESULTS: We found that approximately 50.3% of patients with iNPH exhibited a positive grasp reflex. Among these patients, 69% exhibited bilateral positivity, while the remaining patients showed unilateral positivity. Furthermore, the intensity of the grasp reflex was significantly correlated with the severity of gait and with cognitive, urinary, motor, and behavioural symptoms. Surgical interventions led to a reduction (41.7%) or maintenance (30.6%) of the reflex intensity in 72.3% of iNPH patients. The changes in reflex intensity showed significant positive correlations with changes in the number of steps of the Timed Up and Go test and Trail Making Test-A scores but not with changes in total scores on the iNPH Grading Scale. CONCLUSION: This retrospective study identified grasp reflexes as a highly prevalent phenomenon in patients with iNPH. These reflexes can assist in evaluating the severity of various symptoms, including cognitive, gait, urinary, motor and emotional symptoms.

  8. 特発性正常圧水頭症患者におけるアパシーの質的特徴の検討

    川村 藍, 菅野 重範, 小林 良太, 川勝 忍, 大庭 輝, 井原 一成, 川上 暢子, 森原 啓介, 柿沼 一雄, 松原 史歩, 勝瀬 一登, 鈴木 匡子

    高次脳機能研究　44　(1)　79-80　2024/03

    Publisher: (一社)日本高次脳機能学会

    ISSN： 1348-4818

    eISSN： 1880-6554

  9. Ventriculoperitoneal Shunt Failure 3-year after Shunt Surgery Caused by Migration of Detached Ventricular Catheter into the Cranium: A Case Study of Idiopathic Normal-pressure Hydrocephalus

    Kazuo KAKINUMA, Keisuke MORIHARA, Yoshiteru SHIMODA, Nobuko KAWAKAMI, Shigenori KANNO, Mayuko OTOMO, Teiji TOMINAGA, Kyoko SUZUKI

    NMC Case Report Journal　10　9-14　2023/12/31

    Publisher: Japan Neurosurgical Society

    DOI： 10.2176/jns-nmc.2022-0162 　

    eISSN： 2188-4226

  10. 意図により悪化する着座障害を示した右頭頂後頭葉皮質下出血の一例

    勝瀬 一登, 柿沼 一雄, 森原 啓介, 松原 史歩, 川上 暢子, 川村 藍, 太田 祥子, 菅野 重範, 平山 和美, 鈴木 匡子

    臨床神経心理　34　27-27　2023/12

    Publisher: 東北神経心理懇話会

    ISSN： 1344-0292

    eISSN： 2758-0156

  11. Auditory phonological identification impairment in primary progressive aphasia Peer-reviewed

    Nobuko Kawakami, Shigenori Kanno, Shoko Ota, Keisuke Morihara, Nanayo Ogawa, Kyoko Suzuki

    Cortex　168　130-142　2023/08

    Publisher: Elsevier BV

    DOI： 10.1016/j.cortex.2023.08.007 　

    ISSN： 0010-9452

  12. 原発性進行性失語 (PPA) と聴覚障害─自験例をふまえて─

    Nobuko Kawakami, Shigenori Kanno

    Higher Brain Function Research　43　(2)　161-165　2023/06/30

    Publisher: Japan Society for Higher Brain Dysfunction

    DOI： 10.2496/hbfr.43.161 　

    ISSN： 1348-4818

    eISSN： 1880-6554

  13. 左脳梁膨大後域出血で純粋な道順障害が長期に継続した1例

    岡田 友里, 川上 暢子, 森原 啓介, 柿沼 一雄, 松原 史歩, 菅野 重範, 鈴木 匡子

    高次脳機能研究　43　(1)　104-104　2023/03

    Publisher: (一社)日本高次脳機能学会

    ISSN： 1348-4818

    eISSN： 1880-6554

  14. 原発性進行性失語症における書字障害の検討 非流暢/失文法型と意味型との比較

    太田 祥子, 菅野 重範, 川上 暢子, 森原 啓介, 柿沼 一雄, 松原 史歩, 勝瀬 一登, 稲富 雄一郎, 鈴木 匡子

    高次脳機能研究　43　(1)　40-40　2023/03

    Publisher: (一社)日本高次脳機能障害学会

    ISSN： 1348-4818

    eISSN： 1880-6554

  15. Dyslexia and dysgraphia of primary progressive aphasia in Chinese: A systematic review Peer-reviewed

    Junyan Liu, Shoko Ota, Nobuko Kawakami, Shigenori Kanno, Kyoko Suzuki

    Frontiers in Neurology　13　2022/12/06

    Publisher: Frontiers Media SA

    DOI： 10.3389/fneur.2022.1025660 　

    eISSN： 1664-2295

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    Introduction Currently, little is known about Chinese-speaking primary progressive aphasia (PPA) patients compared to patients who speak Indo-European languages. We examined the demographics and clinical manifestations, particularly reading and writing characteristics, of Chinese patients with PPA over the last two decades to establish a comprehensive profile and improve diagnosis and care. Methods We reviewed the demographic features, clinical manifestations, and radiological features of Chinese-speaking PPA patients from 56 articles published since 1994. We then summarized the specific reading and writing errors of Chinese-speaking patients. Results The average age of onset for Chinese-speaking patients was in their early 60's, and there were slightly more male patients than female patients. The core symptoms and images of Chinese-speaking patients were similar to those of patients who speak Indo-European languages. Reading and writing error patterns differed due to Chinese's distinct tone and orthography. The types of reading errors reported in Chinese-speaking patients with PPA included tonal errors, regularization errors, visually related errors, semantic errors, phonological errors, unrelated errors, and non-response. Among these errors, regularization errors were the most common in semantic variant PPA, and tonal errors were specific to Chinese. Writing errors mainly consisted of non-character errors (stroke, radical/component, visual, pictograph, dyskinetic errors, and spatial errors), phonologically plausible errors, orthographically similar errors, semantic errors, compound word errors, sequence errors, unrelated errors, and non-response. Conclusion This paper provides the latest comprehensive demographic information and unique presentations on the reading and writing of Chinese-speaking patients with PPA. More detailed studies are needed to address the frequency of errors in reading and writing and their anatomical substrates.

  16. Determination of language areas in patients with epilepsy using the super-selective Wada test. International-journal

    Kazuo Kakinuma, Shin-Ichiro Osawa, Hiroaki Hosokawa, Marie Oyafuso, Shoko Ota, Erena Kobayashi, Nobuko Kawakami, Kazushi Ukishiro, Kazutaka Jin, Makoto Ishida, Takafumi Sato, Mika Sakamoto, Kuniyasu Niizuma, Teiji Tominaga, Nobukazu Nakasato, Kyoko Suzuki

    IBRO neuroscience reports　13　156-163　2022/12

    DOI： 10.1016/j.ibneur.2022.08.002 　

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    The Wada test is the gold standard for determining language-dominant hemisphere. However, the precise determination of language areas in each patient requires more invasive methods, such as electrocortical stimulation. Some studies have reported the use of anesthetic injection into selective cerebral arteries to predict postoperative function. To assess the function of the anterior and posterior language areas separately, we developed an advanced test named the "super-selective Wada test" (ssWada). The ssWada procedure is as follows: an endovascular neurosurgeon identifies the arterial branches of the middle cerebral artery (MCA) perfusing the anterior language area of the inferior frontal gyrus and the posterior language area of the posterior part of the superior temporal gyrus using angiography. Behavioral neurologists assess language symptoms before and after propofol administration using a microcatheter tip in the selected arterial branch. From 30 serial patients with epilepsy who underwent ssWada test at Tohoku University Hospital, we retrospectively reviewed patients in whom multiple areas in the bilateral MCA region was examined. Eight cases were identified in this study. All eight cases had been considered for resection of the area overlapping the classical language area. Three of the eight cases were left-dominant, and the within-hemisphere distribution was also considered typical. One case was determined to be left-dominant but atypical in the intra-hemispheric functional distribution. Two cases were right-dominant, and the intra-hemispheric functional distribution was considered a mirror image of the typical pattern. The remaining two cases were considered atypical, not only in terms of bilateral language function, but also in terms of anterior-posterior functional distribution. This case series demonstrates the potential utility of ssWada in revealing separate function of the anterior and posterior language areas. The ssWada allows simulation of local surgical brain resection and detailed investigation of language function, which potentially contributes to planning the resection area. Although indications for ssWada are quite limited, it could play a complementary role to noninvasive testing because it provides information related to resection using a different approach.

  17. Buccofacial apraxia in primary progressive aphasia

    Keisuke Morihara, Shoko Ota, Kazuo Kakinuma, Nobuko Kawakami, Yuichi Higashiyama, Shigenori Kanno, Fumiaki Tanaka, Kyoko Suzuki

    Cortex　2022/11

    Publisher: Elsevier BV

    DOI： 10.1016/j.cortex.2022.10.010 　

    ISSN： 0010-9452

  18. Risk factors for unfavourable outcomes after shunt surgery in patients with idiopathic normal-pressure hydrocephalus

    Erena Kobayashi, Shigenori Kanno, Nobuko Kawakami, Wataru Narita, Makoto Saito, Keiko Endo, Masaki Iwasaki, Tomohiro Kawaguchi, Shigeki Yamada, Kazunari Ishii, Hiroaki Kazui, Masakazu Miyajima, Masatsune Ishikawa, Etsuro Mori, Teiji Tominaga, Fumiaki Tanaka, Kyoko Suzuki

    Scientific Reports　12　(1)　2022/08/17

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-022-18209-5 　

    eISSN： 2045-2322

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    Abstract A number of vascular risk factors (VRFs) have been reported to be associated with idiopathic normal-pressure hydrocephalus (iNPH), but it remains unclear whether these VRFs are related to patient outcomes after shunt surgery. Therefore, we investigated the risk factors for unfavourable outcomes after shunt surgery in iNPH patients using two samples from Tohoku University Hospital and from a multicentre prospective trial of lumboperitoneal (LP) shunt surgery for patients with iNPH (SINPHONI-2). We enrolled 158 iNPH patients. We compared the prevalence of VRFs and clinical measures between patients with favourable and unfavourable outcomes and identified predictors of unfavourable outcomes using multivariate logistic regression analyses. The presence of hypertension, longer disease duration, more severe urinary dysfunction, and a lower Evans’ index were predictors of unfavourable outcomes after shunt surgery. In addition, hypertension and longer disease duration were also predictors in patients with independent walking, and a lower Evans’ index was the only predictor in patients who needed assistance to walk or could not walk. Our findings indicate that hypertension is the only VRF related to unfavourable outcomes after shunt surgery in iNPH patients. Larger-scale studies are needed to elucidate the reason why hypertension can affect the irreversibility of symptoms after shunt placement.

  19. Case Report: Semantic Variant Primary Progressive Aphasia With Impaired Verbal Word Discrimination Peer-reviewed

    Nobuko Kawakami, Ayumi Morita, Shigenori Kanno, Nanayo Ogawa, Kazuo Kakinuma, Yumiko Saito, Erena Kobayashi, Wataru Narita, Kyoko Suzuki

    Frontiers in Neurology　13　2022/06/16

    Publisher: Frontiers Media SA

    DOI： 10.3389/fneur.2022.873735 　

    eISSN： 1664-2295

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    Some patients with primary progressive aphasia (PPA) present with various types of hearing deficits. Research on the auditory function and speech sounds in PPA, including temporal, phonemic, and prosodic processing, revealed impairment in some of these auditory processes. Many patients with PPA who present with impaired word recognition subsequently developed non-fluent variant PPA. Herein, we present a patient with semantic variant PPA (svPPA) who demonstrated impaired verbal word discrimination. Audiological examinations revealed normal auditory brainstem responses and slightly impaired pure-tone perception. By contrast, verbal word discrimination and monosyllable identification were impaired, and temporal auditory acuity deteriorated. Analyses of brain magnetic resonance images revealed a significant decrease in the gray matter volume in bilateral superior temporal areas, predominantly on the left, compared with those of patients with typical svPPA, which appeared to be associated with impaired word recognition in our patient.

  20. Improvement in callosal disconnection syndrome with recovery of callosal connectivity. International-journal

    Keisuke Morihara, Kazuo Kakinuma, Erena Kobayashi, Nobuko Kawakami, Wataru Narita, Shigenori Kanno, Fumiaki Tanaka, Kyoko Suzuki

    Neurocase　27　(3)　323-331　2021/06

    DOI： 10.1080/13554794.2021.1959935 　

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    Recent advancements in radiological techniques have enabled the observation of the topographic distribution of the human corpus callosum. However, its functional connectivity remains to be elucidated. The symptoms of callosal disconnection syndrome (CDS) can potentially reveal the functional connections between the cerebral hemispheres. Herein, we report a patient with CDS, whose callosal lesion was restricted to the posterior midbody, isthmus, and an anterior part of the dorsal splenium. A 53-year-old right-handed woman demonstrated CDS following cerebral infarction associated with subarachnoid hemorrhage. She exhibited CDS including ideomotor apraxia, and tactile anomia with the left hand, cross-replication of hand postures, cross-localization of the fingers, and constructional impairment with the right hand. Six months after onset, the left-handed ideomotor apraxia on imitation improved, but that to command did not, which indicated the difference in the nature of the transcallosal connections between ideomotor apraxia on imitation and ideomotor apraxia to command. Longitudinal CDS observation and corpus callosum tractography will prove useful in expanding our understanding of the nature of the organization of interhemispheric information transference.

  21. Echolalia in patients with primary progressive aphasia. International-journal

    Shoko Ota, Shigenori Kanno, Ayumi Morita, Wataru Narita, Nobuko Kawakami, Kazuo Kakinuma, Yumiko Saito, Erena Kobayashi, Toru Baba, Osamu Iizuka, Yoshiyuki Nishio, Minoru Matsuda, Hayato Odagiri, Keiko Endo, Kentaro Takanami, Etsuro Mori, Kyoko Suzuki

    European journal of neurology　28　(4)　1113-1122　2020/12/11

    DOI： 10.1111/ene.14673 　

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    OBJECTIVE: This study aimed to examine echolalia and its related symptoms and brain lesions in primary progressive aphasia (PPA). METHODS: Forty-five patients with PPA were included: 19 non-fluent/agrammatic variant PPA (nfvPPA), 5 semantic variant PPA, 7 logopenic variant PPA, and 14 unclassified PPA patients. We detected echolalia in unstructured conversations. An evaluation of language function and the presence of parkinsonism, grasp reflex, imitation behaviour, and disinhibition were assessed. We also measured regional cerebral blood flow (rCBF) using single-photon emission computed tomography. RESULTS: Echolalia was observed in 12 nfvPPA and 2 unclassified PPA patients. All patients showed mitigated echolalia. We compared nfvPPA patients with echolalia (echolalia group) to those without echolalia (non-echolalia group). The median age of the echolalia group was significantly lower than that of the non-echolalia group, and the echolalia group showed a significantly worse auditory comprehension performance than the non-echolalia group. In contrast, the performance of repetition tasks was not different between the two groups. The prevalence of imitation behaviour in the echolalia group was significantly higher than that in the non-echolalia group. The rCBFs in the bilateral pre-supplementary motor area and bilateral middle cingulate cortex in the echolalia group were significantly lower than those in the non-echolalia group. CONCLUSIONS: These findings suggest that echolalia is characteristic of nfvPPA patients with preserved repetition and impaired comprehension. Reduced inhibition of the medial frontal cortex with release activity of the anterior perisylvian area account for the emergence of echolalia.

  22. A case of amyloid myopathy diagnosed during the treatment of myopathy associated with anti-signal recognition particle antibodies Peer-reviewed

    Nobuko Kawakami, Yusuke Katsuyama, Yuka Hagiwara, Hidefumi Yoshida, Kang Kim, Kiyoshi Harada

    Clinical Neurology　57　(4)　168-173　2017

    Publisher: Societas Neurologica Japonica

    DOI： 10.5692/clinicalneurol.cn-000974 　

    ISSN： 0009-918X

  23. Peripheral Vitamin C Levels in Alzheimer's Disease: A Cross-Sectional Study Peer-reviewed

    Kazuki Ide, Hiroshi Yamada, Yohei Kawasaki, Mie Yamanaka, Nobuko Kawakami, Yusuke Katsuyama, Hidefumi Yoshida, Kang Kim, Emi Shiosaki, Akihiro Sonoda, Keizo Umegaki, Kiyoshi Harada

    JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY　62　(6)　432-436　2016/12

    DOI： 10.3177/jnsv.62.432 　

    ISSN： 0301-4800

    eISSN： 1881-7742

  24. Lymphocyte vitamin C levels as potential biomarker for progression of Parkinson's disease Peer-reviewed

    Kazuki Ide, Hiroshi Yamada, Keizo Umegaki, Katsuki Mizuno, Nobuko Kawakami, Yuka Hagiwara, Mizuki Matsumoto, Hidefumi Yoshida, Kang Kim, Emi Shiosaki, Tsunehiro Yokochi, Kiyoshi Harada

    NUTRITION　31　(2)　406-408　2015/02

    DOI： 10.1016/j.nut.2014.08.001 　

    ISSN： 0899-9007

    eISSN： 1873-1244

  25. A novel mutation in glycyl-tRNA synthetase caused Charcot-Marie-Tooth disease type 2D with facial and respiratory muscle involvement Peer-reviewed

    Nobuko Kawakami, Kenichi Komatsu, Hirofumi Yamashita, Kengo Uemura, Nobuyuki Oka, Hiroshi Takashima, Ryosuke Takahashi

    Clinical Neurology　54　(11)　911-915　2014

    Publisher: Societas Neurologica Japonica

    DOI： 10.5692/clinicalneurol.54.911 　

    ISSN： 0009-918X

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Misc. 39

  1. 原発性進行性失語症における失文法の評価

    八鍬央子, 八鍬央子, 森原啓介, 川上暢子, 柿沼一雄, 松原史歩, 勝瀬一登, 勝瀬一登, 太田祥子, 小川七世, 川村藍, 菊地花, 菅野重範, 鈴木匡子

    高次脳機能研究　44　(1)　2024

    ISSN： 1348-4818

  2. 左脳梁膨大後域出血で純粋な道順障害が長期に継続した1例

    岡田 友里, 川上 暢子, 森原 啓介, 柿沼 一雄, 松原 史歩, 菅野 重範, 鈴木 匡子

    高次脳機能研究　43　(1)　104-104　2023/03

    Publisher: (一社)日本高次脳機能障害学会

    ISSN： 1348-4818

    eISSN： 1880-6554

  3. シャント術後に浮動性めまいの消失を認めた特発性正常圧水頭症の1例

    松原史歩, 柿沼一雄, 勝瀬一登, 森原啓介, 川上暢子, 菅野重範, 鈴木匡子

    臨床神経学(Web)　63　(4)　2023

    ISSN： 1882-0654

  4. 原発性進行性失語における環境音認知および関連機能の検討

    川上暢子, 菅野重範, 太田祥子, 小川七世, 鈴木匡子

    Dementia Japan　37　(4)　2023

    ISSN： 1342-646X

  5. 原発性進行性失語における動詞呼称と名詞呼称の解離-脳血流低下部位との関連-

    勝瀬一登, 勝瀬一登, 太田祥子, 柿沼一雄, 松原史歩, 川上暢子, 小川七世, 小川七世, 伊関千書, 戸田達史, 松田実, 松田実, 菅野重範, 鈴木匡子

    日本神経心理学会学術集会プログラム予稿集　47th　2023

  6. アルツハイマー病理を背景とする原発性進行性失語の多様性評価と分類

    勝瀬一登, 勝瀬一登, 柿沼一雄, 森原啓介, 森原啓介, 松原史歩, 川上暢子, 小川七世, 小川七世, 太田祥子, 戸田達史, 松田実, 松田実, 菅野重範, 鈴木匡子

    日本神経学会学術大会プログラム・抄録集　64th　2023

  7. 原発性進行性失語の聴覚および聴覚的音韻処理機能障害と関連脳領域の検討

    川上暢子, 太田祥子, 森原啓介, 菅野重範, 鈴木匡子

    日本神経学会学術大会プログラム・抄録集　64th　2023

  8. 発語失行と開鼻声を呈した進行性非流暢性失語の一例

    太田祥子, 川上暢子, 渡部聡, 松村邦也, 森田亜由美, 菅野重範, 森原啓介, 森原啓介, 柿沼一雄, 松原史歩, 勝瀬一登, 勝瀬一登, 松田実, 鈴木匡子

    日本言語聴覚学会(Web)　24th　2023

  9. 原発性進行性失語症における口舌顔面失行の臨床学的特徴と責任病巣について

    森原啓介, 森原啓介, 太田祥子, 柿沼一雄, 川上暢子, 東山雄一, 菅野重範, 田中章景, 鈴木匡子

    日本神経学会学術大会プログラム・抄録集　63rd　2022

  10. 10年に渡り失語症を中心に緩徐に認知機能障害が進行したPPAの一例

    太田祥子, 柿沼一雄, 成田渉, 西尾慶之, 川上暢子, 玉懸綾音, 菅野重範, 森原啓介, 森原啓介, 松原史歩, 遠藤佳子, 松田実, 鈴木匡子

    日本神経心理学会学術集会プログラム予稿集　46th　2022

  11. 特発性正常圧水頭症患者におけるシャント手術後の行動心理症状の改善に関する検討

    松村邦也, 菅野重範, 川上暢子, 小林絵礼奈, 柿沼一雄, 森原啓介, 松原史歩, 大田祥子, 川村藍, 遠藤佳子, 鈴木匡子

    日本神経心理学会学術集会プログラム予稿集　46th　2022

  12. 物忘れ検診で忘れないでおきたいこと~non-amnesticな症状も含めて

    川上暢子

    総合健診　49　(1)　2022

    ISSN： 1347-0086

  13. 経過とともに反響言語が顕著となった進行性非流暢性失語の2症例

    太田祥子, 森田亜由美, 成田渉, 成田渉, 川上暢子, 小林絵礼奈, 小林絵礼奈, 菅野重範, 鈴木匡子

    日本神経心理学会学術集会プログラム予稿集　45th　2021

  14. 発語失行を伴う進行性非流暢性失語の臨床的特徴と脳機能低下部位

    太田祥子, 菅野重範, 森田亜由美, 成田渉, 川上暢子, 小林絵礼奈, 柿沼一雄, 遠藤佳子, 鈴木匡子

    日本神経心理学会学術集会プログラム予稿集　44th　2020

  15. 構音の歪みを伴わない進行性非流暢性失語の一例

    柿沼一雄, 成田渉, 齋藤裕美子, 森田亜由美, 小林絵礼奈, 川上暢子, 菅野重範, 鈴木匡子

    日本高次脳機能障害学会学術総会プログラム・講演抄録　43rd　2019

  16. 時間的文脈の記憶障害を特徴とする“非”前脳基底部健忘の一例

    齋藤裕美子, 成田渉, 川上暢子, 小林絵礼奈, 柿沼一雄, 森田亜由美, 菅野重範, 鈴木匡子

    日本高次脳機能障害学会学術総会プログラム・講演抄録　43rd　2019

  17. 原発性進行性失語を呈したレビー小体病の一例

    小林絵礼奈, 成田渉, 森田亜由美, 柿沼一雄, 齋藤裕美子, 川上暢子, 飯塚統, 菅野重範, 鈴木匡子

    臨床神経学(Web)　59　(1)　2019

    ISSN： 1882-0654

  18. 語音認知の障害を伴った意味性認知症の一例

    川上暢子, 柿沼一雄, 齋藤裕美子, 小林絵礼奈, 成田渉, 菅野重範, 鈴木匡子

    日本神経心理学会学術集会プログラム予稿集　43rd　2019

  19. 多発脳神経障害を来たしIgG4関連肥厚性硬膜炎が疑われた1例

    中川裕亮, 勝山祐輔, 三橋賢大, 萩原由佳, 川上暢子, 吉田英史, 金剛, 原田清

    臨床神経学(Web)　58　(5)　2018

    ISSN： 1882-0654

  20. 認知機能低下者の頭部MRI画像における脳萎縮度と酸化ストレス指標との関連:探索的横断研究

    浜本伸吾, 山中美絵, 池谷怜, 古島大資, 三橋賢大, 勝山裕輔, 川上暢子, 吉田英史, 金剛, 塩崎恵美, 薗田明広, 梅垣敬三, 原田清, 山田浩

    日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会講演要旨集　2017　2017

  21. 左視床病変で発症した単純ヘルペス脳炎の1例

    勝山祐輔, 中川裕亮, 三橋賢大, 萩原由佳, 川上暢子, 吉田英史, 金剛, 山田浩, 原田清

    Neuroinfection　22　(2)　2017

    ISSN： 1348-2718

  22. 多発単神経炎を伴ったIgA血管炎の1例

    勝山祐輔, 中川裕亮, 萩原由佳, 川上暢子, 吉田英史, 金剛, 山田浩, 原田清

    臨床神経学(Web)　57　(12)　2017

    ISSN： 1882-0654

  23. Diabetic lumbosacral radiculoplexus neuropathyの一例

    川上暢子, 中川裕亮, 勝山祐輔, 三橋賢大, 萩原由佳, 吉田英史, 金剛, 山田浩, 原田清

    臨床神経学(Web)　57　(12)　2017

    ISSN： 1882-0654

  24. A case of amyloid myopathy diagnosed during the treatment of myopathy associated with anti-signal recognition particle antibodies

    川上暢子, 勝山祐輔, 萩原由佳, 吉田英史, 金剛, 原田清

    臨床神経学(Web)　57　(4)　2017

    ISSN： 1882-0654

  25. 急性に両上肢麻痺・心肺停止を来たした脊髄梗塞の1例

    中川裕亮, 勝山祐輔, 萩原由佳, 川上暢子, 吉田英史, 金剛, 原田清

    臨床神経学(Web)　57　(1)　2017

    ISSN： 1882-0654

  26. 左視床病変で発症した単純ヘルペス脳炎の1例

    勝山祐輔, 中川裕亮, 萩原由佳, 川上暢子, 吉田英史, 金剛, 山田浩, 原田清

    臨床神経学(Web)　57　(1)　2017

    ISSN： 1882-0654

  27. 認知機能低下者を対象とした自主臨床試験の症例組み入れにおける工夫

    山中美絵, 井出和希, 川崎洋平, 勝山祐輔, 川上暢子, 吉田英史, 金剛, 原田清, 梅垣敬三, 山田浩, 山田浩

    CRCと臨床試験のあり方を考える会議プログラム・抄録集　16th　2016

  28. 診断に苦慮した血管内大細胞型B細胞性リンパ腫(IVLBCL)の1例

    熊澤高雄, 萩原由佳, 川上暢子, 吉田英史, 金剛, 山田浩, 原田清

    臨床神経学(Web)　55　(3)　2015

    ISSN： 1882-0654

  29. 消化管出血にて肝性脳症が誘発されたRendu-Osler-Weber病の一例

    川上暢子, 熊澤高雄, 吉田英史, 金剛, 山田浩, 原田清

    臨床神経学(Web)　55　(9)　2015

    ISSN： 1882-0654

  30. 顔面筋・呼吸筋も罹患したCMT病type2DでGARS遺伝子に新規変異を認めた1例

    川上暢子, 川上暢子, 小松研一, 小松研一, 高橋由佳子, 山下博史, 植村健吾, 植村健吾, 高嶋博, 高橋良輔

    臨床神経学　54　(1)　2014

    ISSN： 0009-918X

  31. 脳幹に興味深い画像所見を認めた単純ヘルペス脳炎の1例

    松本瑞樹, 萩原由佳, 川上暢子, 澤村正典, 吉田英史, 金剛, 山田浩, 原田清

    臨床神経学　54　(2)　2014

    ISSN： 0009-918X

  32. 興味深い画像所見を呈したAIDSに合併した進行性多巣性白質脳症の一例

    萩原由佳, 松本瑞樹, 川上暢子, 吉田英史, 金剛, 原田清

    臨床神経学　54　(3)　2014

    ISSN： 0009-918X

  33. ラクナ梗塞発症後に脳動脈瘤を合併した若年女性の1例

    松本瑞樹, 萩原由佳, 川上暢子, 丸濱紳一朗, 吉田英史, 金剛, 山田浩, 原田清

    臨床神経学　54　(7)　2014

    ISSN： 0009-918X

  34. 当初辺縁系脳炎と診断した,CO中毒の一例

    萩原由佳, 松本瑞樹, 川上暢子, 吉田英史, 金剛, 原田清

    臨床神経学　54　(7)　2014

    ISSN： 0009-918X

  35. 脳実質病変を伴った特発性肥厚性硬膜炎の一例

    川上暢子, 萩原由佳, 松本瑞樹, 山田浩, 吉田英史, 金剛, 原田清

    臨床神経学　54　(7)　2014

    ISSN： 0009-918X

  36. Val263Glyミスセンス変異を認めた眼球運動失行と低アルブミン血症を伴う早期発症型失調症(EAOH)の1例

    坂本光弘, 川上暢子, 小松研一, 石川奈々, 川村眞弓, 横関明男, 小野寺理, 西澤正豊

    臨床神経学　54　(7)　2014

    ISSN： 0009-918X

  37. 大学病院におけるクリプトコッカス髄膜炎の治療経験

    川上 暢子, 陣上 直人, 山下 博史, 川又 純, 猪原 匡史, 植村 健吾, 松本 理器, 高折 晃史, 高橋 良輔

    NEUROINFECTION　17　(2)　202-202　2012/10

    Publisher: 日本神経感染症学会

    ISSN： 1348-2718

    eISSN： 2435-2225

  38. 診断に苦慮したリンパ腫の一例

    赤澤賢一郎, 伊東孝政, 岡村直樹, 山本紗織, 川上暢子, 日比野真, 宮沢善夫, 緒方清行

    日本病院総合診療医学会雑誌　3　(1)　2012

    ISSN： 2185-8136

  39. 対側顔面の持続性発汗過多を呈した視床・視床下核梗塞の62歳男性例

    川上暢子, 伊藤恒, 服部紗苗, 佐野輝典, 亀井徹正

    臨床神経学　51　(5)　2011

    ISSN： 0009-918X

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Presentations 11

  1. 原発性進行性失語の聴覚および聴覚的音韻処理機能障害と関連脳領域の検討

    第64回日本神経学会学術大会　2023/06/01

  2. 原発性進行性失語（PPA）と聴覚障害

    川上暢子

    第46回日本高次脳機能障害学会学術総会　2022/12/03

  3. 症例から学ぶ神経心理学：記憶障害の診断って意外に難しい

    川上暢子

    第63回日本神経学会学術大会　2022/05/18

  4. 物忘れ検診で忘れないでおきたいこと~non-amnesticな症状も含めて Invited

    川上暢子

    日本総合健診医学会第50回大会　2022/01/28

  5. 語音認知の障害を伴った意味性認知症の一例

    川上暢子

    日本神経心理学会学術集会　2019/08/26

  6. 視空間認知障害を初発症状とする変性性認知症の鑑別ー2症例での対比からー

    川上 暢子, 伊関千書, 近藤敏行, 公平瑠奈, 佐藤大祐, 鈴木佑哉, 猪狩龍佑, 佐藤裕康, 小山信吾, 鈴木匡子, 石澤賢一

    第101回日本神経学会東北地方会　2018/03/10

  7. Diabetic lumbosacral radiculoplexus neuropathyの一例

    川上 暢子

    第148回日本神経学会東海北陸地方会　2017/07/15

  8. 抗SRP抗体陽性壊死性ミオパチーとして加療中、アミロイドミオパチーの診断に至った一例

    川上 暢子

    第144回日本神経学会東海北陸地方会　2016/03/12

  9. Guillain-Barré症候群にFisher症候群を合併しバリスム様不随意運動を呈した一例

    川上 暢子

    第142回日本神経学会東海北陸地方会　2015/06/27

  10. 消化管出血にて肝性脳症が誘発されたRendu-Osler-Weber病の一例

    川上 暢子

    第140回日本神経学会東海北陸地方会　2014/11/01

  11. 大学病院神経内科におけるクリプトコッカス髄膜炎の治療経験

    川上 暢子

    第17回日本神経感染症学会総会　2012/10/20

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Research Projects 1

  1. 認知症疾患における幻視・錯視への視覚イメージの影響～「大きさ/サイズ感」の歪み

    川上 暢子

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 若手研究

    Category: 若手研究

    Institution: 東北大学

    2019/04/01 - 2023/03/31

    More details Close

    レビー小体型認知症患者でみられる幻視・錯視の中には、子供や小人が多い、ポケットの中に人が見えたりするなど、周囲の風景の中に実物とサイズが異なるものが見える場合が存在する。本研究の目的は、このようなサイズ感の異常が疑われる幻視・錯視を経験したレビー小体型認知症患者において、その臨床的特徴や、サイズ感の認知の異常およびサイズ違和・風景違和があった場合の気づきの障害について、新規の課題を使用して評価を行うことであった。しかし、コロナ禍の影響で入院患者数が制限されたため、研究計画として挙げていたレビー小体型認知症患者に対するサイズ感違和の評価のための新規の課題を十分な人数に対して施行することができず、統計学的評価の信頼性に欠けると判断され、同内容での研究継続が困難となった。このため、過去に施行した風景パレイドリア検査および神経画像検査の結果を用いて、サイズ感異常を疑われる患者について後方視的に評価することとした。2013年以降に当院当科に入院してレビー小体型認知症の診断(Probable DLB)となった患者を抽出した。風景パレイドリアおよびノイズパレイドリア検査の反応を確認し、同一の風景画像内で複数のパレイドリアが出現した反応の中で明らかに実際のサイズと異なるパレイドリアが混在していた反応を、サイズ感異常と評価して抽出した。視知覚・視空間認知や注意などの他の認知機能障害との関連や、頭部MRI・脳血流SPECTを用いて統計解析を進めている。