Details of the Researcher

PHOTO

Hiromasa Tanno
Section
Graduate School of Medicine
Job title
Associate Professor
Degree

Research History 5

  • 2026/07 - Present
    東北大学大学院医学系研究科看護技術開発学分野 准教授

  • 2023/02 - 2026/06
    東北大学大学院医学系研究科看護技術開発学分野 講師

  • 2022/06 - 2023/01
    東北大学大学院医学系研究科 看護技術開発学分野 助教

  • 2016/04 - 2022/05
    Tohoku University　Graduate School of Medicine

  • 2015/04 - 2016/03
    Tohoku University　Graduate School of Medicine

Committee Memberships 5

  • コ・メディカル形態機能学会　学術委員

    2024/04 - Present

  • 公益社団法人 日本看護科学学会　JANS若手の会エリア・コーディネーター

    2022 - Present

  • 日本創傷治癒学会　評議員、教育委員

    2022 - Present

  • 看護理工学会　査読委員

    2018 - Present

  • 宮城県看護協会　仙台北支部書記

    2022/04 - 2024/03

Professional Memberships 9

  • 日本肥満学会

    2023/10 - Present

  • 日本熱傷学会

    2023/04 - Present

  • 日本看護科学学会

    2021/08 - Present

  • 日本創傷・オストミー・失禁管理学会

    2021/02 - Present

  • 日本看護技術学会

    2020/10 - Present

  • コ・メディカル形態機能学会

    2019/04 - Present

  • THE JAPANESE SOCIETY FOR IMMUNOLOGY

    2012 - Present

  • JAPANESE SOCIETY OF PRESSURE ULCERS

    2011/04 - Present

  • 日本創傷治癒学会

    2010/04 - Present

︎Show all ︎Show first 5

Research Interests 10

  • 乾癬

  • アトピー性皮膚炎

  • 肥満記憶

  • 肥満

  • 難治性創傷

  • 創傷治癒

  • 慢性創傷

  • 褥瘡

  • 免疫

  • 看護

Research Areas 2

  • Life sciences / Basic nursing /

  • Life sciences / Plastic and reconstructive surgery /

Awards 4

  1. 研究奨励賞

    2020/11　第50回日本創傷治癒学会

  2. コ・メディカル形態機能学会 学会奨励賞

    2019/09

  3. 最優秀演題賞

    2018/09　第20回日本褥瘡学会学術集会

  4. Future Innovation in Wound Care Award 2012

    2012/09

Papers 97

  1. Decreased levels of reduced glutathione impair Th1 immune responses and exacerbate Cryptococcus neoformans infection in diabetic mice

    Ko Sato, Naoki Kanbayashi, Michiko Yoshida, Emi Kanno, Hiromasa Tanno, Yuki Sato, Keiko Ishii, Tetsuji Aoyagi, Kazuyoshi Kawakami

    Microbial Pathogenesis　2026/10

    DOI： 10.1016/j.micpath.2026.108741 　

  2. Immunological mechanism behind reactivated cryptococcosis in persistently infected mice following FTY720 treatment. International-journal

    Michiko Yoshida, Ko Sato, Nana Nakahata, Hayato Sato, Reina Ohagi, Emi Kanno, Hiromasa Tanno, Keiko Ishii, Tetsuji Aoyagi, Atsuo Kikuchi, Kazuyoshi Kawakami

    Infection and immunity　e0061225　2026/04/30

    DOI： 10.1128/iai.00612-25 　

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    The Cryptococcus neoformans species complex (CNSC), responsible for cryptococcosis, is controlled by Th1-type immunity, in which IFN-γ-activated macrophages form granulomas that contain infection. Nevertheless, CNSC can evade host immunity and, after the primary infection phase, can shift to a latent infection similar to tuberculosis. Reactivation is thought to occur when immune control fails, but the underlying mechanisms remain poorly understood. FTY720, a functional antagonist of sphingosine-1-phosphate receptors, is primarily used in the treatment of multiple sclerosis. However, there have been reports linking its use to instances of cryptococcosis in patients undergoing treatment. To explore this, we established a novel mouse model using CnT-II mice, which express CD4+ T cell receptors specific for chitin deacetylase 2 (Cda2), a major T cell antigen of CNSC. Following infection with encapsulated CNSC, mice developed persistent pulmonary fungal burdens (10²-10³ CFU) accompanied by granulomatous responses, modeling latent infection. Upon FTY720 administration, mice exhibited increased pulmonary fungal burdens, disrupted granuloma integrity, and reduced IFN-γ and IL-12 production. FTY720 also markedly decreased CD4+ effector memory (Tem) and effector T cells (Teff) in the lungs, with a particularly profound loss of IFN-γ-producing Tem cells. These findings indicate that our model successfully recapitulates latent cryptococcal infection and reactivation, and demonstrate that FTY720 promotes relapse by depleting protective IFN-γ-producing CD4+ Tem cells and impairing Th1-mediated immunity. Given the rising use of FTY720, our study highlights its potential risk in patients with subclinical cryptococcosis and underscores the need for preventive strategies to avert disease progression.

  3. A transparent osmotic wound dressing ATKPAD promotes the healing process and regulates hypoxia-dependent inflammatory responses. International-journal

    Yuki Sato, Eiki Ito, Hiromasa Tanno, Takashi Kanno, Ryuto Arai, Koji Sato, Ayato Kaneta, Wakana Kamada, Ikue Sone, Ko Sato, Shinyo Ishi, Toshiro Imai, Hiromu Matsunaga, Tetsuji Aoyagi, Yoshimichi Imai, Yoshiyuki Adachi, Emi Kanno

    Scientific reports　16　(1)　2026/03/06

    DOI： 10.1038/s41598-026-41264-1 　

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    The inflammatory response after skin injury initiates wound healing by promoting the release of cytokines and growth factors essential for tissue repair. Modern wound dressings promote healing by maintaining a moist, hypoxic environment. ATKPAD is a novel wound dressing that accelerates healing developed by Okamoto Industries, Inc. Composed of reduced starch syrup and a semi-permeable membrane, it was launched in Japan as a Class III medical device in 2024. Transparent ATKPAD allows wound visibility and absorbs exudate in a molecular-weight-dependent manner, with its semi-permeable membrane retaining larger molecules, like cytokines, while letting small molecules pass through osmotic effects rather than specific binding. However, the detailed molecular and cellular mechanisms of ATKPAD remain unclear. In this study, we examined its effect on full-thickness excisional wound healing. We analyzed the in vitro permeability of cytokines and growth factors and evaluated granulation tissue formation, angiogenesis, neutrophil infiltration, and cytokine and growth factor production in vivo. We observed an increase in cytokines and growth factors alongside accelerated wound healing with ATKPAD. Its application enhanced granulation tissue formation and neutrophil infiltration, accompanied by increased expression of Hif1α. These findings suggest that ATKPAD promotes wound healing by creating a hypoxic microenvironment that enhances early-phase inflammation. (Word count: 200).

  4. Immunomodulatory effect of mannoprotein, a Dectin-2 ligand, in a murine model of food allergy

    Yingnan Guo, Makoto Ogata, Hiroyuki Hattori, Shunsuke Nishio, Soma Sugawara, Ting-Yu Cheng, Konosuke Kameda, Yuna Muto, Junjie Li, Hiromasa Tanno, Naoki Shoji, Tomomi Miyata, Eiichi Tsuruta, Keietsu Abe, Emi Kanno, Yoichiro Iwakura, Tomonori Nochi, Stefan Vieths, Stephan Scheurer, Taiki Miyazawa, Tsukasa Matsuda, Masako Toda

    2026

    DOI： 10.2139/ssrn.7163478 　

  5. High Fat Diet-Induced Obesity Alters Cutaneous Immune Cell Function, and These Changes Persist After Weight Loss. International-journal

    Wakana Kamada, Hiromasa Tanno, Rena Takayashiki, Yuki Sato, Shinyo Ishi, Miki Shoji, Ko Sato, Tetsuji Aoyagi, Emi Kanno

    Journal of immunology research　2026　(1)　e3930910　2026

    DOI： 10.1155/jimr/3930910 　

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    Obesity is recognized as a chronic low-grade inflammation that contributes to metabolic disorders. Weight loss (WL) is well known to improve metabolic disorders. However, recent studies have shown that the changes in immune cells associated with obesity exhibit immunological memory even after WL. Obesity impairs skin barrier function and exacerbates inflammatory skin diseases, such as psoriasis. While skin immune cells maintain homeostasis and defense, the impact of obesity on these cells in intact skin is understudied, as research mainly focuses on skin with an inflammatory skin disease model in the context of obesity. The effect of WL on skin immunity is even less clear. Therefore, this study aimed to investigate these discrepancies. Mice were assigned to the lean group (regular diet), the obese group (high-fat diet for 18 weeks), and the WL group (high-fat diet for 9 weeks followed by regular diet for 9 weeks). Following 18 weeks of feeding, mouse skin was excised, and immune cell populations within the skin were analyzed using real-time PCR and flow cytometry. In addition, the effects of WL on psoriasis were examined using an imiquimod-induced psoriasis mouse model. We observed increased expression of RORγt, IL-17A, and CCL20 in intact skin in both the obese and WL groups. In the psoriasis model, disease severity was further exacerbated by WL. Moreover, whereas the Vγ4+Vγ5- γδ T cell population was increased in the lean group, the Vγ4-Vγ5- γδ T cell population remained elevated following WL, similar to levels observed in the obese group. These observations indicated that obesity may imprint a memorized immune response in the skin, which is not abrogated by WL. This study is the first to demonstrate this persistent effect on skin immunity. These findings imply that individuals who have experienced obesity may remain at increased risk for inflammatory skin conditions, even after WL.

  6. NKT cell-dependent PspA-specific IgA production caused by mucosal administration of a novel nanoparticle pneumococcal vaccine. International-journal

    Ayako Nakahira, Hiroki Iwaoka, Ko Sato, Shigenari Ishizuka, Ryuhei Shiroma, Tomomitsu Miyasaka, Emi Kanno, Hiromasa Tanno, Yuki Sato, Yukihiro Akeda, Kazunori Oishi, Tetsuji Aoyagi, Keiko Ishii, Kazuyoshi Kawakami

    Vaccine　68　127911-127911　2025/12/05

    DOI： 10.1016/j.vaccine.2025.127911 　

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    Pneumonia is one of the leading causes of death worldwide, with Streptococcus pneumoniae being a major causative agent of community-acquired pneumonia. In immunocompromised infants and the elderly, this pathogen can invade the bloodstream and cerebrospinal fluid, leading to invasive pneumococcal diseases (IPDs), such as bacteremia and meningitis. Currently, vaccines targeting the capsular polysaccharides of pneumococcus are available to prevent pneumococcal infection. However, these vaccines have limitations, including incomplete coverage of all serotypes. Therefore, there is a need for next-generation vaccines that are independent of serotype variation. In this study, we developed a novel pneumococcal vaccine using pneumococcal surface protein A (PspA), a virulence factor presents on the surface of all pneumococcal strains, as the antigen. PspA was conjugated with iron oxide nanoparticles (IONPs), serving as both a carrier and a potential adjuvant. When administered intratracheally to mice, this vaccine, PspA-IONP, induced the formation of inducible bronchus-associated lymphoid tissue (iBALT) in the lungs and stimulated antibody production both systemically and on mucosal surfaces, thereby conferring resistance to pneumococcal infection. We focused on invariant natural killer T (iNKT) cells due to their role in antibody production by B cells. Notably, mucosal IgA antibodies induced by this vaccine were significantly reduced in iNKT cell-deficient (Jα18KO) mice compared to wild-type mice. The expression of pIgR, which is crucial for IgA secretion, as well as the production of several cytokines involved in pIgR expression and B cell activation, were also significantly decreased in Jα18KO mice. These results suggest that iNKT cells play a central role in promoting IgA secretion by directly or indirectly inducing multiple cytokines. PspA-IONP demonstrates potential as a novel vaccine platform that induces anti-pneumococcal immunity. Furthermore, this platform can be adapted to combat other respiratory infections by modifying the antigen conjugated to the IONPs.

  7. Defect of Dectin-1-mediated signaling promotes burn wound healing through attenuated oxidative stress and inflammatory responses. International-journal

    Yuki Sato, Hiromasa Tanno, Toshiro Imai, Mai Konno, Rena Takayashiki, Wakana Kamada, Eiki Ito, Ikue Sone, Shiho Kawamoto, Shinyo Ishi, Ko Sato, Keiko Ishii, Tetsuji Aoyagi, Yoichiro Iwakura, Emi Kanno

    Burns : journal of the International Society for Burn Injuries　51　(9)　107703-107703　2025/12

    DOI： 10.1016/j.burns.2025.107703 　

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    BACKGROUND: In burn wound healing, inflammation and oxidative stress are major contributors to delayed repair. Damage-associated molecular patterns (DAMPs) derived from injured tissue activate inflammatory signaling pathways through receptors, such as C-type lectin receptors (CLRs). Dectin-1, one of the receptors for DAMPs, contributes to the production of inflammatory cytokines and reactive oxygen species (ROS). The purpose of this study was to investigate the role of Dectin-1 in burn wound healing using Dectin-1-deficient (KO) mice and the antagonist laminarin. METHOD: Full-thickness burn wounds were created on the dorsal skin of wild-type (WT) C57BL/6 mice and Dectin-1KO mice by applying a 90°C soldering iron for 10 s. We analyzed the percentage of wound closure, the area of granulation tissue, angiogenesis, and inflammatory responses. To evaluate the effect of the topical administration of the Dectin-1 antagonist laminarin, we applied laminarin or vehicle at the burned sites daily and examined burn wound healing. RESULTS: The percentages of wound closure, granulation tissue area, and angiogenesis were significantly enhanced in Dectin-1KO mice compared with WT mice. Dectin-1 deficiency also led to reduced production of inflammatory cytokines such as TNF-α and IFN-γ, and the oxidative damage marker 4-HNE. Furthermore, daily topical administration of the antagonist laminarin promoted burn wound healing. CONCLUSIONS: These results suggest that Dectin-1-mediated signaling inhibits burn wound healing by inducing the production of inflammatory cytokines and oxidative stress. Furthermore, topical administration of the Dectin-1 antagonist laminarin may serve as a promising novel treatment for healing after burn.

  8. A transparent osmotic wound dressing ATKPAD promotes healing by retaining cytokines and inducing hypoxia-driven inflammation

    Yuki Sato, Eiki Ito, Hiromasa Tanno, Takashi Kanno, Ryuto Arai, Ayato Kaneta, Wakana Kamada, Ikue Sone, Ko Sato, Shinyo Ishi, Toshiro Imai, Hiromu Matsunaga, Tetsuji Aoyagi, Yoshimichi Imai, Yoshiyuki Adachi, Emi Kanno

    2025/05/26

    Publisher: Springer Science and Business Media LLC

    DOI： 10.21203/rs.3.rs-6729108/v1 　

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    Abstract <p>The inflammatory response after skin injury is crucial for activating the wound-healing process involving cytokine and growth factor secretion essential for tissue repair. Modern wound dressings promote healing by maintaining a moist, hypoxic environment. ATKPAD is a novel wound dressing that accelerates healing developed by Okamoto Industries, Inc. Composed of reduced starch syrup and a semi-permeable membrane, it was launched in Japan as a Class III advanced medical device in 2024. ATKPAD is unique in its transparency, allowing clear wound visibility, and selectively absorbs wound exudate through the combined effects of osmotic pressure and its semi-permeable membrane. However, the detailed molecular and cellular mechanisms of ATKPAD remain unclear. In this study, we examined its effect on acute wound healing. We analyzed the in vitro permeability of cytokines and growth factors and evaluated granulation tissue formation, angiogenesis, neutrophil infiltration, and cytokine and growth factor production in vivo. We found that cytokines and growth factors were selectively retained by ATKPAD. Its application enhanced granulation tissue formation and neutrophil infiltration, accompanied by increased hypoxia marker expression. These findings suggest that ATKPAD promotes wound healing by creating a hypoxic microenvironment that enhances early-phase inflammation while preserving key bioactive factors at the wound site.</p>

  9. Batroxobin promotes wound healing after burn injury by enhancing blood flow. International-journal

    Toshiro Imai, Yuki Sato, Hiromasa Tanno, Wakana Kamada, Shinyo Ishi, Miki Shoji, Hiromu Matsunaga, Ko Sato, Yoshimichi Imai, Emi Kanno

    Plastic and reconstructive surgery　2025/04/01

    DOI： 10.1097/PRS.0000000000012137 　

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    BACKGROUND: In the process of burn wound healing, promoting healing and suppressing wound progression by enhancing blood flow is considered essential. Various agents that increase blood flow are currently being assessed. Batroxobin (DF-521; Defibrase®) is a denitrogenating agent extracted from Bothrops moojeni, used as a thrombin-like serine protease to improve ischemic conditions. However, it remains unclear how this agent affects the burn wound healing process. In this study, we conducted analyses to define the effects of batroxobin administration on burn wound healing. METHODS: Full-thickness burn wounds were created on the dorsal skin of C57BL/6 mice by applying a 90℃, 5-mm-diameter soldering iron for 10 s. Immediately after wounding, batroxobin (30 batroxobin units/kg/mouse) was administered intraperitoneally daily. As a vehicle control, the same volume of saline was administered. We analyzed wound area, histological findings, blood flow, growth factor and chemokine synthesis, and ischemia-reperfusion related factor expression. RESULTS: We found that the systemic administration of batroxobin prevented burn wound progression, which was accompanied by decreased expression of TNF-α and NOX2 and reduced synthesis of Hif-1α. In addition, this agent promoted wound healing by enhancing blood flow, increasing S100A4-positive fibroblast accumulation, and stimulating the production of growth factors (bFGF, EGF, and PlGF). CONCLUSIONS: These results indicate that the systemic administration of batroxobin prevented burn wound progression and accelerated the healing process by enhancing blood flow. (Word count: 222).

  10. Contribution of CARD9 signaling to wound healing in skin promoted by topical administration of heat-killed Enterococcus faecalis strain KH2 and the involvement of Dectin-2. International-journal

    Shiho Kurosaka, Hiromasa Tanno, Minako Hirose, Wakana Kamada, Rena Takayashiki, Ikue Sone, Yuki Sato, Takumi Watanabe, Shinyo Ishi, Miki Shoji, Yoshimichi Imai, Ko Sato, Keiko Ishii, Hiromitsu Hara, Sho Yamasaki, Shinobu Saijo, Yoichiro Iwakura, Kazuyoshi Kawakami, Emi Kanno

    Frontiers in immunology　16　1550934-1550934　2025

    DOI： 10.3389/fimmu.2025.1550934 　

    ISSN： 1664-3224

  11. Innate phase production of IFN-γ by memory and effector T cells expressing early activation marker CD69 during infection with Cryptococcus deneoformans in the lungs. International-journal

    Anna Miyahara, Aya Umeki, Ko Sato, Toshiki Nomura, Hideki Yamamoto, Tomomitsu Miyasaka, Daiki Tanno, Ikumi Matsumoto, Tong Zong, Takafumi Kagesawa, Akiho Oniyama, Kotone Kawamura, Xiaoliang Yuan, Rin Yokoyama, Yuki Kitai, Emi Kanno, Hiromasa Tanno, Hiromitsu Hara, Sho Yamasaki, Shinobu Saijo, Yoichiro Iwakura, Keiko Ishii, Kazuyoshi Kawakami

    Infection and immunity　92　(6)　e0002424　2024/05/03

    DOI： 10.1128/iai.00024-24 　

    ISSN： 0019-9567

    eISSN： 1098-5522

  12. THE ROLE OF DECTIN-1 AND CARD9 SIGNALLING TO BURN WOUND HEALING ON SKIN

    Hiromasa Tanno

    WOUND REPAIR AND REGENERATION　2024

  13. THE EFFECTS OF BATROXOBIN ON SKIN WOUND HEALING: IN VIVO AND IN VITRO STUDIES

    Hiromasa Tanno

    WOUND REPAIR AND REGENERATION　2024

  14. CUTANEOUS WOUND HEALING PROMOTED BY TOPICAL ADMINISTRATION OF HEAT-KILLED Lactobacillus plantarum KB131 AND POSSIBLE CONTRIBUTION OF CARD9-MEDIATED SIGNALLING

    Hiromasa Tanno

    WOUND REPAIR AND REGENERATION　2024

  15. CUTANEOUS WOUND HEALING PROMOTED BY TOPICAL ADMINISTRATION OF HEAT-KILLED Enterococcus faecalis KH2-COMPARISON BETWEEN A SINGLE-ADMINISTARTION AND MULTIPLE-ADMINISTRATION

    Hiromasa Tanno

    WOUND REPAIR AND REGENERATION　2024

  16. EFFECT OF TOPICAL ADMINISTRATION OF HEAT-KILLED Enterococcus faecalis STRAIN KH2 ON RAT PRESSURE ULCERS MODEL

    Hiromasa Tanno

    WOUND REPAIR AND REGENERATION　2024

  17. クリプトコックス潜在性感染マウスモデルを用いたFingolimod(FTY720)投与による内因性再燃の免疫機序の解明

    吉田 美智子, 中畑 那奈, 篠宮 岳志, 佐藤 光, 菅野 恵美, 丹野 寛大, 石井 恵子, 青柳 哲史, 菊池 敦生, 川上 和義

    日本小児感染症学会総会・学術集会プログラム・抄録集　55回　183-183　2023/11

    Publisher: (一社)日本小児感染症学会

  18. CARD9-mediated macrophage responses and collagen fiber capsule formation caused by textured-type breast implants. International-journal

    Miki Shoji, Emi Kanno, Hiromasa Tanno, Kenji Yamaguchi, Sinyo Ishi, Naoyuki Takagi, Shiho Kurosaka, Ko Sato, Momoko Niiyama, Akihiko Ito, Keiko Ishii, Yoshimichi Imai, Kazuyoshi Kawakami, Masahiro Tachi

    Plastic and reconstructive surgery　154　(5)　906e-917e-917e　2023/10/17

    DOI： 10.1097/PRS.0000000000011152 　

    ISSN： 0032-1052

    eISSN： 1529-4242

  19. Cutaneous wound healing promoted by topical administration of heat-killed Lactobacillus plantarum KB131 and possible contribution of CARD9-mediated signaling. International-journal

    Shinyo Ishi, Emi Kanno, Hiromasa Tanno, Shiho Kurosaka, Miki Shoji, Toshiro Imai, Kenji Yamaguchi, Kanna Kotsugai, Momoko Niiyama, Haruko Kurachi, Fuko Makabe, Takumi Watanabe, Ko Sato, Keiko Ishii, Hiromitsu Hara, Yoshimichi Imai, Kazuyoshi Kawakami

    Scientific reports　13　(1)　15917-15917　2023/09/23

    DOI： 10.1038/s41598-023-42919-z 　

    ISSN： 2045-2322

    eISSN： 2045-2322

  20. CONTRIBUTION OF CARD9-MEDIATED SIGNALLING TO WOUND HEALING IN SKIN PROMOTED BY ADMINISTRATION OF Enterococcus faecalis KH2

    Hiromasa Tanno

    WOUND REPAIR AND REGENERATION　2022

  21. ACTIVATION OF NATURL KILLER T CELLS BY alpha-GalCer PROMOTE THE CLEARANCE OF Pseudomonas aeruginosa FROM WOUND

    Hiromasa Tanno

    WOUND REPAIR AND REGENERATION　2022

  22. THE EFFECTS OF ADMINISTRATION OF BATROXOBIN IN SKIN WOUND HEALING

    Hiromasa Tanno

    WOUND REPAIR AND REGENERATION　2022

  23. Deficiency of lung-specific claudin-18 leads to aggravated infection with Cryptococcus deneoformans through dysregulation of the microenvironment in lungs International-journal Peer-reviewed

    Ko Sato, Ikumi Matsumoto, Koya Suzuki, Atsushi Tamura, Aki Shiraishi, Hiroshi Kiyonari, Jun Kasamatsu, Hideki Yamamoto, Tomomitsu Miyasaka, Daiki Tanno, Anna Miyahara, Tong Zong, Takafumi Kagesawa, Akiho Oniyama, Kotone Kawamura, Yuki Kitai, Aya Umeki, Emi Kanno, Hiromasa Tanno, Keiko Ishii, Sachiko Tsukita, Kazuyoshi Kawakami

    Scientific Reports　11　(1)　21110-21110　2021/12

    DOI： 10.1038/s41598-021-00708-6 　

    ISSN： 2045-2322

    eISSN： 2045-2322

  24. Topical administration of heat-killed enterococcus faecalis strain KH2 promotes re-epithelialization and granulation tissue formation during skin wound-healing International-journal Peer-reviewed

    Hiromasa Tanno, Emi Kanno, Shiho Kurosaka, Yukari Oikawa, Takumi Watanabe, Ko Sato, Jun Kasamatsu, Tomomitsu Miyasaka, Shinyo Ishi, Miki Shoji, Naoyuki Takagi, Yoshimichi Imai, Keiko Ishii, Masahiro Tachi, Kazuyoshi Kawakami

    Biomedicines　9　(11)　2021/11

    DOI： 10.3390/biomedicines9111520 　

    eISSN： 2227-9059

  25. Role of Dectin-2 in the phagocytosis of Cryptococcus neoformans by dendritic cells. International-journal Peer-reviewed

    Yuki Kitai, Ko Sato, Daiki Tanno, Xiaoliang Yuan, Aya Umeki, Jun Kasamatsu, Emi Kanno, Hiromasa Tanno, Hiromitsu Hara, Sho Yamasaki, Shinobu Saijo, Yoichiro Iwakura, Keiko Ishii, Kazuyoshi Kawakami

    Infection and immunity　89　(10)　IAI0033021　2021/07/12

    DOI： 10.1128/IAI.00330-21 　

    ISSN： 0019-9567

    eISSN： 1098-5522

  26. Dectin-2-mediated initiation of immune responses caused by influenza virus hemagglutinin Peer-reviewed

    Hideki YAMAMOTO, Chikako TOMIYAMA, Ko SATO, Jun KASAMATSU, Kazuki TAKANO, Aya UMEKI, Nana NAKAHATA, Tomomitsu MIYASAKA, Emi KANNO, Hiromasa TANNO, Sho YAMASAKI, Shinobu SAIJO, Yoichiro IWAKURA, Keiko ISHII, Kazuyoshi KAWAKAMI

    Biomedical Research　42　(2)　53-66　2021/04/10

    DOI： 10.2220/biomedres.42.53 　

    ISSN： 0388-6107

    eISSN： 1880-313X

  27. Contribution of Invariant Natural Killer T Cells to the Clearance of Pseudomonas aeruginosa from Skin Wounds. International-journal Peer-reviewed

    Hiromasa Tanno, Emi Kanno, Suzuna Sato, Yu Asao, Mizuki Shimono, Shiho Kurosaka, Yukari Oikawa, Shinyo Ishi, Miki Shoji, Ko Sato, Jun Kasamatsu, Tomomitsu Miyasaka, Hideki Yamamoto, Keiko Ishii, Yoshimichi Imai, Masahiro Tachi, Kazuyoshi Kawakami

    International journal of molecular sciences　22　(8)　2021/04/10

    DOI： 10.3390/ijms22083931 　

    ISSN： 1661-6596

    eISSN： 1422-0067

  28. EFFECTS OF iNKT CELL DEFICIENCY ON DECTIN-2-MEDIATED DELAY IN SKIN WOUND HEALING

    Hiromasa Tanno

    WOUND REPAIR AND REGENERATION　2021

  29. ANALYSIS OF DECTIN-1 and DECTIN-2 EXPRESSING CELLS AND ENDOGENOUS LIGANDS IN SKIN WOUNDS

    Hiromasa Tanno

    WOUND REPAIR AND REGENERATION　2021

  30. Effect of CARD9 deficiency on neutrophil-mediated host defense against pulmonary infection with streptococcus pneumoniae International-journal

    Shigenari Ishizuka, Rin Yokoyama, Ko Sato, Ryuhei Shiroma, Ayako Nakahira, Hideki Yamamoto, Kazuki Takano, Takafumi Kagesawa, Tomomitsu Miyasaka, Jun Kasamatsu, Emi Kanno, Hiromasa Tanno, Keiko Ishii, Kazuyoshi Kawakami

    Infection and Immunity　89　(1)　2021/01

    DOI： 10.1128/IAI.00305-20 　

    ISSN： 0019-9567

    eISSN： 1098-5522

  31. Distinct Roles for Dectin-1 and Dectin-2 in Skin Wound Healing and Neutrophilic Inflammatory Responses International-journal Peer-reviewed

    Kenji Yamaguchi, Emi Kanno, Hiromasa Tanno, Ayako Sasaki, Yuki Kitai, Takayuki Miura, Naoyuki Takagi, Miki Shoji, Jun Kasamatsu, Ko Sato, Yuka Sato, Momoko Niiyama, Yuka Goto, Keiko Ishii, Yoshimichi Imai, Shinobu Saijo, Yoichiro Iwakura, Masahiro Tachi, Kazuyoshi Kawakami

    Journal of Investigative Dermatology　141　(1)　164-176.e8　2021/01

    DOI： 10.1016/j.jid.2020.04.030 　

    ISSN： 0022-202X

    eISSN： 1523-1747

  32. Dectin-2シグナルを介した皮膚創傷治癒遅延へのNatural Killer T細胞欠損の影響

    丹野 寛大, 菅野 恵美, 佐々木 綾子, 黒坂 志歩, 及川 ゆかり, 石井 恵子, 川上 和義, 館 正弘

    日本創傷治癒学会プログラム・抄録集　50回　70-70　2020/11

    Publisher: (一社)日本創傷治癒学会

  33. 乳酸菌Enterococcus faecalis KH2株が皮膚創傷治癒に与える影響

    黒坂 志歩, 丹野 寛大, 菅野 恵美, 及川 ゆかり, 石井 恵子, 川上 和義, 館 正弘

    日本創傷治癒学会プログラム・抄録集　50回　75-75　2020/11

    Publisher: (一社)日本創傷治癒学会

  34. Limited role of mincle in the host defense against infection with cryptococcus deneoformans International-journal

    Yuki Sato, Ko Sato, Hideki Yamamoto, Jun Kasamatsu, Tomomitsu Miyasaka, Daiki Tanno, Anna Miyahara, Takafumi Kagesawa, Akiho Oniyama, Kotone Kawamura, Rin Yokoyama, Yuki Kitai, Aya Umeki, Shigenari Ishizuka, Kazuki Takano, Ryuhei Shiroma, Nana Nakahata, Kaori Kawakami, Emi Kanno, Hiromasa Tanno, Sho Yamasaki, Hiromitsu Hara, Keiko Ishii, Kazuyoshi Kawakamia

    Infection and Immunity　88　(11)　2020/11

    DOI： 10.1128/IAI.00400-20 　

    ISSN： 0019-9567

    eISSN： 1098-5522

  35. Novel Toll-Like Receptor 9 Agonist Derived from Cryptococcus neoformans Attenuates Allergic Inflammation Leading to Asthma Onset in Mice International-journal Peer-reviewed

    Kaori Dobashi-Okuyama, Kazuyoshi Kawakami, Tomomitsu Miyasaka, Ko Sato, Keiko Ishii, Kaori Kawakami, Chiaki Masuda, Syugo Suzuki, Jun Kasamatsu, Hideki Yamamoto, Daiki Tanno, Emi Kanno, Hiromasa Tanno, Tasuku Kawano, Motoaki Takayanagi, Tomoko Takahashi, Isao Ohno

    International Archives of Allergy and Immunology　181　(9)　651-664　2020/09/01

    DOI： 10.1159/000508535 　

    ISSN： 1018-2438

    eISSN： 1423-0097

  36. 褥瘡感染対策の新展開 褥瘡の感染・バイオフィルムに対する治療・ケア ターゲットの再考

    菅野 恵美, 川上 和義, 丹野 寛大, 山口 賢次, 館 正弘

    日本褥瘡学会誌　22　(3)　245-245　2020/08

    Publisher: (一社)日本褥瘡学会

    ISSN： 1345-0417

  37. Production of IL-17A at innate immune phase leads to decreased Th1 immune response and attenuated host defense against infection with cryptococcus deneoformans International-journal Peer-reviewed

    Ko Sato, Hideki Yamamoto, Toshiki Nomura, Jun Kasamatsu, Tomomitsu Miyasaka, Daiki Tanno, Ikumi Matsumoto, Takafumi Kagesawa, Anna Miyahara, Tong Zong, Akiho Oniyama, Kotone Kawamura, Rin Yokoyama, Yuki Kitai, Shigenari Ishizuka, Emi Kanno, Hiromasa Tanno, Hiromi Suda, Masanobu Morita, Masayuki Yamamoto, Yoichiro Iwakura, Keiko Ishii, Kazuyoshi Kawakami

    Journal of Immunology　205　(3)　686-698　2020/08/01

    DOI： 10.4049/jimmunol.1901238 　

    ISSN： 0022-1767

    eISSN： 1550-6606

  38. 緑膿菌に学び、緑膿菌を操る 皮膚創傷治癒の免疫機構と緑膿菌感染とのクロストーク

    菅野 恵美, 川上 和義, 丹野 寛大, 山口 賢次, 館 正弘

    感染症学雑誌　94　(臨増)　154-155　2020/03

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  39. Current trearment of biofilm formation in chronic wounds

    Hiromasa Tanno

    WOUND REPAIR AND REGENERATION　2020

  40. Effect of interferon- γ deficiency on the wound healing process in skin

    Hiromasa Tanno

    WOUND REPAIR AND REGENERATION　2020

  41. Defect of mincle leads to impaired wound healing in skin

    Hiromasa Tanno

    WOUND REPAIR AND REGENERATION　2020

  42. Effect of dectin-2-mediated signaling on skin wound healing and netosis

    Hiromasa Tanno

    WOUND REPAIR AND REGENERATION　2020

  43. 皮膚創傷治癒におけるDectin-1,2の役割とNETs形成との関連

    山口 賢次, 川上 和義, 菅野 恵美, 佐々木 綾子, 庄司 未樹, 三浦 孝行, 丹野 寛大, 高木 尚之, 今井 啓道, 館 正弘

    日本創傷治癒学会プログラム・抄録集　49回　108-108　2019/12

    Publisher: (一社)日本創傷治癒学会

  44. Defect of interferon γ leads to impaired wound healing through prolonged neutrophilic inflammatory response and enhanced MMP-2 activation International-journal Peer-reviewed

    Emi Kanno, Hiromasa Tanno, Airi Masaki, Ayako Sasaki, Noriko Sato, Maiko Goto, Mayu Shisai, Kenji Yamaguchi, Naoyuki Takagi, Miki Shoji, Yuki Kitai, Ko Sato, Jun Kasamatsu, Keiko Ishii, Tomomitsu Miyasaka, Kaori Kawakami, Yoshimichi Imai, Yoichiro Iwakura, Ryoko Maruyama, Masahiro Tachi, Kazuyoshi Kawakami

    International Journal of Molecular Sciences　20　(22)　2019/11/02

    DOI： 10.3390/ijms20225657 　

    ISSN： 1661-6596

    eISSN： 1422-0067

  45. Natural killer T細胞が創部緑膿菌排除および治癒に与える影響

    佐々木 綾子, 丹野 寛大, 佐藤 すずな, 霜野 瑞葵, 石井 恵子, 丸山 良子, 館 正弘, 川上 和義, 菅野 恵美

    形態・機能　18　(1)　59-59　2019/08

    Publisher: コ・メディカル形態機能学会

    ISSN： 1347-7145

    eISSN： 1884-6084

  46. 乳酸菌Enterococcus faecalis局所投与による皮膚創傷治癒の促進

    丹野 寛大, 黒坂 志歩, 島谷 香波, 佐々木 綾子, 石井 恵子, 丸山 良子, 館 正弘, 川上 和義, 菅野 恵美

    形態・機能　18　(1)　60-60　2019/08

    Publisher: コ・メディカル形態機能学会

    ISSN： 1347-7145

    eISSN： 1884-6084

  47. 乳酸菌Enterococcus faecalis KH株のもつ免疫賦活作用が創傷治癒に与える影響

    丹野 寛大, 菅野 恵美, 黒坂 志歩, 島谷 香波, 佐々木 綾子, 石井 恵子, 丸山 良子, 川上 和義, 館 正弘

    日本褥瘡学会誌　21　(3)　308-308　2019/07

    Publisher: (一社)日本褥瘡学会

    ISSN： 1345-0417

  48. Dectin-2–Mediated Signaling Leads to Delayed Skin Wound Healing through Enhanced Neutrophilic Inflammatory Response and Neutrophil Extracellular Trap Formation International-journal Peer-reviewed

    Takayuki Miura, Kazuyoshi Kawakami, Emi Kanno, Hiromasa Tanno, Hiroyuki Tada, Noriko Sato, Airi Masaki, Rin Yokoyama, Kotone Kawamura, Yuki Kitai, Naoyuki Takagi, Kenji Yamaguchi, Natsuki Yamaguchi, Yoshika Kyo, Keiko Ishii, Yoshimichi Imai, Shinobu Saijo, Yoichiro Iwakura, Masahiro Tachi

    Journal of Investigative Dermatology　139　(3)　702-711　2019/03

    DOI： 10.1016/j.jid.2018.10.015 　

    ISSN： 0022-202X

    eISSN： 1523-1747

  49. 創傷治癒のプロセスとメカニズム(トランスレーショナルリサーチ) 皮膚創傷治癒におけるDectin-1、2シグナル活性化の影響の違い

    山口 賢次, 川上 和義, 菅野 恵美, 丹野 寛大, 佐々木 綾子, 三浦 孝行, 高木 尚之, 館 正弘

    日本創傷治癒学会プログラム・抄録集　48回　112-112　2018/11

    Publisher: (一社)日本創傷治癒学会

  50. Dectin-2シグナル活性化による創傷治癒遅延へのNatural Killer T細胞の関与

    佐々木 綾子, 菅野 恵美, 丹野 寛大, 石井 恵子, 丸山 良子, 川上 和義, 館 正弘

    日本創傷治癒学会プログラム・抄録集　48回　157-157　2018/11

    Publisher: (一社)日本創傷治癒学会

  51. 緑膿菌接種創の治癒過程におけるNatural Killer T細胞の役割

    丹野 寛大, 菅野 恵美, 佐藤 すずな, 霜野 瑞葵, 佐々木 綾子, 山口 賢次, 石井 恵子, 丸山 良子, 川上 和義, 館 正弘

    日本創傷治癒学会プログラム・抄録集　48回　171-171　2018/11

    Publisher: (一社)日本創傷治癒学会

  52. 緑膿菌接種創の治癒過程と菌排除におけるNKT細胞欠損の影響

    丹野 寛大, 菅野 恵美, 佐藤 すずな, 山口 賢次, 石井 恵子, 丸山 良子, 川上 和義, 館 正弘

    日本褥瘡学会誌　20　(3)　294-294　2018/09

    Publisher: (一社)日本褥瘡学会

    ISSN： 1345-0417

  53. 緑膿菌接種創の治癒過程と菌排除におけるNKT細胞欠損の影響

    丹野 寛大, 菅野 恵美, 佐藤 すずな, 山口 賢次, 石井 恵子, 丸山 良子, 川上 和義, 館 正弘

    日本褥瘡学会誌　20　(3)　294-294　2018/09

    Publisher: (一社)日本褥瘡学会

    ISSN： 1345-0417

  54. Mozart's and Bach's music yielded little relaxation effect as indicated HR, BP, and autonomic nervous activity

    Junko Hoshi, Hongxia Yang, Xinru Sun, Hiromasa Tanno, Emi Kanno, Ryoko Maruyama

    FASEB JOURNAL　32　(1)　2018/04

    ISSN： 0892-6638

    eISSN： 1530-6860

  55. Do sprinters and distance runners have the same autonomic nervous system activity and hemodynamic responses?

    Xinru Sun, Sayaka Saito, Hongxia Yang, Junko Hoshi, Hiromasa Tanno, Emi Kanno, Ryoko Maruyama

    FASEB JOURNAL　32　(1)　2018/04

    ISSN： 0892-6638

    eISSN： 1530-6860

  56. CONTRIBUTION OF CARD9-MEDIATED SIGNALING TO WOUND HEALING IN SKIN

    Hiromasa Tanno

    WOUND REPAIR AND REGENERATION　2018

  57. LOCAL ACTIVATION OF INKT CELLS BY A-GALCER ACCELERATES SKIN WOUND HEALING

    Hiromasa Tanno

    WOUND REPAIR AND REGENERATION　2018

  58. INVOLVEMENT OF INTERFERON-γ ON THE WOUND HEALING IN SKIN

    Hiromasa Tanno

    WOUND REPAIR AND REGENERATION　2018

  59. EFFECT OF MINCLE-DEFICIENCY ON THE WOUND HEALING PROCESS IN SKIN

    Hiromasa Tanno

    WOUND REPAIR AND REGENERATION　2018

  60. Experimental wound ischemia does not promote Pseudomonas aeruginosa biofilm formation. Peer-reviewed

    Emi Kanno, Hiromasa Tanno, Kenji Yamaguchi, Ayako Sasaki, Ryoko Maruyama, Masahiro Tachi

    Journal of Dermatology and Dermatologic Surgery　22　(2)　68-71　2018

    DOI： 10.4103/jdds.jdds_33_18 　

    ISSN： 2352-2410

    eISSN： 2352-2429

  61. 皮膚創傷におけるDectin-2シグナルを介した治癒過程及びNETosisの制御

    三浦 孝行, 川上 和義, 菅野 恵美, 丹野 寛大, 多田 浩之, 佐藤 紀子, 正木 愛梨, 高木 尚之, 山口 賢次, 石井 恵子, 館 正弘

    日本創傷治癒学会プログラム・抄録集　47回　147-147　2017/11

    Publisher: (一社)日本創傷治癒学会

  62. マウス皮膚創傷治癒過程におけるMincle遺伝子欠損の影響

    佐藤 紀子, 菅野 恵美, 丹野 寛大, 正木 愛梨, 高木 尚之, 石井 恵子, 丸山 良子, 川上 和義, 館 正弘

    日本創傷治癒学会プログラム・抄録集　47回　146-146　2017/11

    Publisher: (一社)日本創傷治癒学会

  63. 創傷治癒過程におけるインターフェロンγ欠損の影響

    正木 愛梨, 菅野 恵美, 丹野 寛大, 佐藤 紀子, 三浦 孝行, 山口 賢次, 石井 恵子, 川上 和義, 館 正弘

    日本創傷治癒学会プログラム・抄録集　47回　145-145　2017/11

    Publisher: (一社)日本創傷治癒学会

  64. 皮膚創傷治癒過程におけるNKT細胞の役割 好中球性炎症に注目して

    丹野 寛大, 菅野 恵美, 佐藤 紀子, 正木 愛梨, 三浦 孝行, 山口 賢次, 石井 恵子, 丸山 良子, 川上 和義, 館 正弘

    日本創傷治癒学会プログラム・抄録集　47回　128-128　2017/11

    Publisher: (一社)日本創傷治癒学会

  65. 創傷感染管理の最前線 Biofilm-based wound therapy バイオフィルムに対する治療・ケア 何をターゲットとするべきか?

    菅野 恵美, 川上 和義, 丹野 寛大, 山口 賢次, 館 正弘

    日本創傷治癒学会プログラム・抄録集　47回　75-75　2017/11

    Publisher: (一社)日本創傷治癒学会

  66. Contribution of CARD9-mediated signalling to wound healing in skin International-journal Peer-reviewed

    Emi Kanno, Kazuyoshi Kawakami, Hiromasa Tanno, Aiko Suzuki, Noriko Sato, Airi Masaki, Ayano Imamura, Naoyuki Takagi, Takayuki Miura, Hideki Yamamoto, Keiko Ishii, Hiromitsu Hara, Yoshimichi Imai, Ryoko Maruyama, Masahiro Tachi

    Experimental Dermatology　26　(11)　1097-1104　2017/11

    DOI： 10.1111/exd.13389 　

    ISSN： 0906-6705

    eISSN： 1600-0625

  67. Invariant NKT cells promote skin wound healing by preventing a prolonged neutrophilic inflammatory response International-journal Peer-reviewed

    Hiromasa Tanno, Kazuyoshi Kawakami, Emi Kanno, Aiko Suzuki, Naoyuki Takagi, Hideki Yamamoto, Keiko Ishii, Yoshimichi Imai, Ryoko Maruyama, Masahiro Tachi

    Wound Repair and Regeneration　25　(5)　805-815　2017/09

    DOI： 10.1111/wrr.12588 　

    ISSN： 1067-1927

    eISSN： 1524-475X

  68. IL-17A promotes neutrophilic inflammation and disturbs acute wound healing in skin International-journal Peer-reviewed

    Naoyuki Takagi, Kazuyoshi Kawakami, Emi Kanno, Hiromasa Tanno, Atsushi Takeda, Keiko Ishii, Yoshimichi Imai, Yoichiro Iwakura, Masahiro Tachi

    Experimental Dermatology　26　(2)　137-144　2017/02/01

    DOI： 10.1111/exd.13115 　

    ISSN： 0906-6705

    eISSN： 1600-0625

  69. The Relaxation Effects of Hand-Massage Therapy on Autonomic Nervous System Function and Emotions: Increases in Eye Contact and Communication

    Hiromasa Tanno

    FASEB JOURNAL　2017

  70. Pedometer-determined physical activities of daily living can affect blood pressure regulation in healthy young adults after postural change

    Hiromasa Tanno

    FASEB JOURNAL　2017

  71. Critical role of tumor necrosis factor-α in the early process of wound healing in skin Peer-reviewed

    Hiromasa Tanno

    JOURNAL OF DERMATOLOGY DERMATOLOGIC SURGERY-JDDS　21　14-19　2017

    DOI： 10.1016/J.JDDS.2016.09.001 　

  72. マウス皮膚創傷治癒過程におけるMincle遺伝子欠損の影響

    佐藤 紀子, 菅野 恵美, 丹野 寛大, 正木 愛梨, 高木 尚之, 石井 恵子, 丸山 良子, 川上 和義, 館 正弘

    日本創傷治癒学会プログラム・抄録集　46回　189-189　2016/12

    Publisher: (一社)日本創傷治癒学会

  73. マウス皮膚創傷治癒過程におけるインターフェロン-γの影響に関する研究

    正木 愛梨, 菅野 恵美, 丹野 寛大, 佐藤 紀子, 石井 恵子, 丸山 良子, 川上 和義, 館 正弘

    日本創傷治癒学会プログラム・抄録集　46回　188-188　2016/12

    Publisher: (一社)日本創傷治癒学会

  74. NKT細胞の活性化が創傷治癒過程に与える影響 α-GalCer創部投与による検証

    丹野 寛大, 川上 和義, 菅野 恵美, 今村 彩乃, 佐藤 紀子, 正木 愛梨, 高木 尚之, 石井 恵子, 丸山 良子, 館 正弘

    日本創傷治癒学会プログラム・抄録集　46回　163-163　2016/12

    Publisher: (一社)日本創傷治癒学会

  75. マウス皮膚創傷治癒過程におけるCARD9を介したシグナル伝達の影響

    菅野 恵美, 川上 和義, 丹野 寛大, 鈴木 愛子, 佐藤 紀子, 正木 愛梨, 高木 尚之, 石井 恵子, 丸山 良子, 館 正弘

    日本創傷治癒学会プログラム・抄録集　46回　126-126　2016/12

    Publisher: (一社)日本創傷治癒学会

  76. Reconsideration of iodine in wound irrigation: The effects on Pseudomonas aeruginosa biofilm formation Peer-reviewed

    E. Kanno, H. Tanno, A. Suzuki, R. Kamimatsuno, M. Tachi

    Journal of Wound Care　25　(6)　335-339　2016/06

    DOI： 10.12968/jowc.2016.25.6.335 　

    ISSN： 0969-0700

  77. Glucosylceramide administration as a vaccination strategy in mouse models of cryptococcosis International-journal Peer-reviewed

    Visesato Mor, Amir M. Farnoud, Ashutosh Singh, Antonella Rella, Hiromasa Tanno, Keiko Ishii, Kazuyoshi Kawakami, Toshiya Sato, Maurizio Del Poeta

    PLoS ONE　11　(4)　e0153853　2016/04

    DOI： 10.1371/journal.pone.0153853 　

    ISSN： 1932-6203

    eISSN： 1932-6203

  78. Ethnic Differences In Effects Of Low Birth Weight On Risk For Hypertension Among Healthy Young Japanese, Mongolian And Han Chinese Volunteers

    Hiromasa Tanno

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　2016

  79. Promotion of acute-phase skin wound healing by Pseudomonas aeruginosa C<inf>4</inf>-HSL International-journal Peer-reviewed

    Emi Kanno, Kazuyoshi Kawakami, Shinichi Miyairi, Hiromasa Tanno, Aiko Suzuki, Rina Kamimatsuno, Naoyuki Takagi, Tomomitsu Miyasaka, Keiko Ishii, Naomasa Gotoh, Ryoko Maruyama, Masahiro Tachi

    International Wound Journal　13　(6)　1325-1335　2016

    DOI： 10.1111/iwj.12523 　

    ISSN： 1742-4801

    eISSN： 1742-481X

  80. Contribution of invariant natural killer T cells to skin wound healing International-journal Peer-reviewed

    Hiromasa Tanno, Kazuyoshi Kawakami, Masae Ritsu, Emi Kanno, Aiko Suzuki, Rina Kamimatsuno, Naoyuki Takagi, Tomomitsu Miyasaka, Keiko Ishii, Yoshimichi Imai, Ryoko Maruyama, Masahiro Tachi

    American Journal of Pathology　185　(12)　3248-3257　2015/12

    DOI： 10.1016/j.ajpath.2015.08.012 　

    ISSN： 0002-9440

    eISSN： 1525-2191

  81. 創傷治癒過程におけるNKT細胞活性化の影響

    丹野 寛大, 川上 和義, 菅野 恵美, 高木 尚之, 上松野 りな, 石井 恵子, 丸山 良子, 館 正弘

    日本創傷治癒学会プログラム・抄録集　45回　99-99　2015/11

    Publisher: (一社)日本創傷治癒学会

  82. 創傷治癒過程におけるI型インターフェロンの影響に関する研究

    上松野 りな, 菅野 恵美, 川上 和義, 丹野 寛大, 高木 尚之, 石井 恵子, 丸山 良子, 館 正弘

    日本創傷治癒学会プログラム・抄録集　45回　98-98　2015/11

    Publisher: (一社)日本創傷治癒学会

  83. NKT細胞制御による新たな慢性皮膚潰瘍の治療法開発への基礎研究

    丹野 寛大, 川上 和義, 鈴木 愛子, 菅野 恵美, 高木 尚之, 上松野 りな, 石井 恵子, 丸山 良子, 館 正弘

    日本褥瘡学会誌　17　(3)　335-335　2015/07

    Publisher: (一社)日本褥瘡学会

    ISSN： 1345-0417

  84. 創傷治癒の基礎 IL-17Aによる好中球性炎症を介した創傷治癒遅延機構の解明

    高木 尚之, 川上 和義, 菅野 恵美, 丹野 寛大, 武田 睦, 上松野 りな, 石井 恵子, 館 正弘

    日本褥瘡学会誌　17　(3)　300-300　2015/07

    Publisher: (一社)日本褥瘡学会

    ISSN： 1345-0417

  85. 緑膿菌が創部アポトーシス誘導に与える影響

    菅野 恵美, 川上 和義, 丹野 寛大, 鈴木 愛子, 上松野 りな, 石井 恵子, 高木 尚之, 丸山 良子, 館 正弘

    日本創傷治癒学会プログラム・抄録集　44回　75-75　2014/12

    Publisher: (一社)日本創傷治癒学会

  86. 創傷治癒におけるIL-17の役割に関する研究

    高木 尚之, 川上 和義, 菅野 恵美, 丹野 寛大, 武田 睦, 鈴木 愛子, 上松野 りな, 石井 恵子, 館 正弘

    日本創傷治癒学会プログラム・抄録集　44回　58-58　2014/12

    Publisher: (一社)日本創傷治癒学会

  87. 創傷治癒過程における1型インターフェロンの関与

    上松野 りな, 菅野 恵美, 川上 和義, 丹野 寛大, 鈴木 愛子, 高木 尚之, 石井 恵子, 丸山 良子, 館 正弘

    日本創傷治癒学会プログラム・抄録集　44回　57-57　2014/12

    Publisher: (一社)日本創傷治癒学会

  88. マウス皮膚創傷治癒過程におけるCARD9遺伝子欠損の影響

    鈴木 愛子, 菅野 恵美, 川上 和義, 丹野 寛大, 上松野 りな, 高木 尚之, 石井 恵子, 丸山 良子, 館 正弘

    日本創傷治癒学会プログラム・抄録集　44回　57-57　2014/12

    Publisher: (一社)日本創傷治癒学会

  89. NKT細胞による好中球性炎症反応の制御を介した皮膚創傷治癒の促進

    丹野 寛大, 川上 和義, 菅野 恵美, 鈴木 愛子, 上松野 りな, 石井 恵子, 丸山 良子, 館 正弘

    日本創傷治癒学会プログラム・抄録集　44回　55-55　2014/12

    Publisher: (一社)日本創傷治癒学会

  90. Neutrophil-derived tumor necrosis factor-α contributes to acute wound healing promoted by N-(3-oxododecanoyl)-l-homoserine lactone from Pseudomonas aeruginosa International-journal Peer-reviewed

    Emi Kanno, Kazuyoshi Kawakami, Shinichi Miyairi, Hiromasa Tanno, Hirono Otomaru, Arina Hatanaka, Shiori Sato, Keiko Ishii, Denso Hayashi, Nobuhito Shibuya, Yoshimichi Imai, Naomasa Gotoh, Ryoko Maruyama, Masahiro Tachi

    Journal of Dermatological Science　70　(2)　130-138　2013/05

    DOI： 10.1016/j.jdermsci.2013.01.004 　

    ISSN： 0923-1811

    eISSN： 1873-569X

  91. SKIN WOUND HEALING AND INFLAMMATORY RESPONSE PROMOTED BY A QUORUM-SENSING MOLECULE FROM PSEUDOMONAS AERUGINOSA

    Hiromasa Tanno

    WOUND REPAIR AND REGENERATION　2013

  92. 災害拠点病院の事業継続の見地からみたエレベータの現状―東日本大震災宮城県災害拠点病院調査―． Peer-reviewed

    中川敦寛, 古川宗, 工藤大介, 阿部喜子, 松村隆志, 丹野寛大, 岡本智子, 久道周彦, 山内聡, 久志本成樹, 冨永悌二

    日本集団災害医学会誌.　18　(1)　9-17　2013

    Publisher:

    ISSN： 1345-7047

  93. Low-energy extracorporeal shock wave therapy enhances skin wound healing in diabetic mice: A critical role of endothelial nitric oxide synthase International-journal Peer-reviewed

    Denso Hayashi, Kazuyoshi Kawakami, Kenta Ito, Keiko Ishii, Hiromasa Tanno, Yoshimichi Imai, Emi Kanno, Ryoko Maruyama, Hiroaki Shimokawa, Masahiro Tachi

    Wound Repair and Regeneration　20　(6)　887-895　2012/11

    DOI： 10.1111/j.1524-475X.2012.00851.x 　

    ISSN： 1067-1927

    eISSN： 1524-475X

  94. Skin wound healing and cytokine response promoted by a quorum-sensing molecule from Pseudomonas aeruginosa Peer-reviewed

    Hiromasa Tanno

    JOURNAL OF IMMUNOLOGY　188　2012/05/01

    ISSN： 0022-1767

  95. THE ROLE OF NATURAL KILLER T CELLS IN SKIN WOUND HEALING Peer-reviewed

    Hiromasa Tanno

    WOUND REPAIR AND REGENERATION　20　(1)　A7　2012/01

    ISSN： 1067-1927

  96. 皮膚創傷治癒過程におけるbFGF産生へのTNF-αの関与

    菅野 恵美, 丹野 寛大, 館 正弘

    日本褥瘡学会誌　14　(2)　113-120　2012

    Publisher:

    ISSN： 1345-0417

  97. Wound healing in skin promoted by inoculation with Pseudomonas aeruginosa PAO1: The critical role of tumor necrosis factor-α secreted from infiltrating neutrophils International-journal Peer-reviewed

    Emi Kanno, Kazuyoshi Kawakami, Masae Ritsu, Keiko Ishii, Hiromasa Tanno, Sohachi Toriyabe, Yoshimichi Imai, Ryoko Maruyama, Masahiro Tachi

    Wound Repair and Regeneration　19　(5)　608-621　2011/09

    DOI： 10.1111/j.1524-475X.2011.00721.x 　

    ISSN： 1067-1927

    eISSN： 1524-475X

Show all ︎Show first 5

Misc. 97

  1. 乳酸菌Enterococcus faecalis KH2由来培養上清が創傷治癒に与える影響 細胞外小胞に着目して

    曽根 育恵, 伊藤 永貴, 川元 詩穂, 松永 拓, 鎌田 若奈, 高屋敷 玲奈, 佐藤 佑樹, 丹野 寛大, 今井 啓道, 菅野 恵美

    日本褥瘡学会誌　28　(1)　50-50　2026/02

    Publisher: (一社)日本褥瘡学会

    ISSN： 1345-0417

    eISSN： 2760-1986

  2. 浸透圧吸収性ドレッシング材(ATKパッド)が創傷治癒過程に与える影響 好中球集積に注目して

    伊藤 永貴, 佐藤 佑樹, 丹野 寛大, 鎌田 若奈, 高屋敷 玲奈, 曽根 育恵, 川元 詩穂, 松永 拓, 今井 啓道, 菅野 恵美

    日本褥瘡学会誌　28　(1)　50-51　2026/02

    Publisher: (一社)日本褥瘡学会

    ISSN： 1345-0417

    eISSN： 2760-1986

  3. 新世代創傷被覆材の現状 浸透圧吸水性創傷被覆材ATK PADによる新たな創傷管理

    伊師 森葉, 松永 拓, 佐藤 佑樹, 今井 利郎, 丹野 寛大, 庄司 未樹, 鳥谷部 荘八, 菅野 恵美, 今井 啓道

    日本創傷治癒学会プログラム・抄録集　55回　78-78　2025/12

    Publisher: (一社)日本創傷治癒学会

  4. 肥満後の体重減少が皮膚創傷治癒過程に与える影響 皮膚白血球に注目して

    丹野 寛大, 鎌田 若奈, 伊藤 永貴, 曽根 育恵, 佐藤 佑樹, 伊師 森葉, 菅野 恵美

    日本創傷治癒学会プログラム・抄録集　55回　101-101　2025/12

    Publisher: (一社)日本創傷治癒学会

  5. 高分散性ナノ型乳酸菌による皮膚全層欠損創感染モデルマウスへの影響

    松永 拓, 丹野 寛大, 佐藤 佑樹, 田辺 志緒里, 曽根 育恵, 今井 利郎, 今井 啓道, 菅野 恵美

    日本創傷治癒学会プログラム・抄録集　55回　104-104　2025/12

    Publisher: (一社)日本創傷治癒学会

  6. Dectin-1アンタゴニスト局所投与による熱傷治癒の促進

    佐藤 佑樹, 丹野 寛大, 菅野 恵美, 今井 利郎, 伊師 森葉

    熱傷　51　(4)　220-221　2025/11

    Publisher: (一社)日本熱傷学会

    ISSN： 0285-113X

    eISSN： 2435-1571

  7. 乳酸菌Enterococcus faecalis KH2由来膜小胞(Membrane Vesicle:MV)がマクロファージ分極化に与える影響

    曽根 育恵, 丹野 寛大, 佐藤 佑樹, 伊藤 永貴, 川元 詩穂, 菅野 恵美

    日本乳酸菌学会誌　36　(3)　131-131　2025/10

    Publisher: 日本乳酸菌学会

    ISSN： 1343-327X

    eISSN： 2186-5833

  8. 乳酸菌Enterococcus faecalis KH2とLactiplantibacillus plantarum KB131が炎症性皮膚疾患に与える影響

    川元 詩穂, 丹野 寛大, 高屋敷 玲奈, 伊藤 永貴, 曽根 育恵, 佐藤 佑樹, 菅野 恵美

    日本乳酸菌学会誌　36　(3)　138-138　2025/10

    Publisher: 日本乳酸菌学会

    ISSN： 1343-327X

    eISSN： 2186-5833

  9. 褥瘡発生・難治化メカニズム研究の最前線 肥満による皮膚創傷治癒遅延の免疫記憶 体重減少後も持続する免疫細胞の変化

    丹野 寛大

    日本褥瘡学会誌　27　(3)　246-246　2025/08

    Publisher: (一社)日本褥瘡学会

    ISSN： 1345-0417

    eISSN： 2760-1986

  10. Enterococcus faecalis KH2由来の細胞外小胞が創傷治癒に与える影響 投与回数による効果検証

    曽根 育恵, 伊藤 永貴, 佐藤 佑樹, 丹野 寛大, 菅野 恵美

    日本褥瘡学会誌　27　(3)　345-345　2025/08

    Publisher: (一社)日本褥瘡学会

    ISSN： 1345-0417

    eISSN： 2760-1986

  11. Dectin-1アンタゴニスト局所投与による熱傷治癒の促進

    佐藤 佑樹, 丹野 寛大, 今井 利郎, 伊師 森葉, 菅野 恵美

    日本熱傷学会総会・学術集会プログラム・抄録集　51回　139-139　2025/05

    Publisher: (一社)日本熱傷学会

  12. 浸透圧吸収性ドレッシング材であるATKパッドの創傷治癒に対する基礎研究

    伊藤永貴, 佐藤佑樹, 丹野寛大, 菅野恵美

    日本褥瘡学会誌　26　(3)　2024

    ISSN： 1345-0417

  13. Analysis of the exacerbation of cryptococcal infection and the underlying immune mechanisms in diabetic mice

    佐藤光, 神林直希, 丹野寛大, 菅野恵美, 青柳哲史, 青柳哲史, 石井恵子, 川上和義

    日本生体防御学会学術総会講演抄録集　35th (Web)　2024

  14. バトロキソビンがマウス熱傷に与える影響の解析

    今井利郎, 佐藤佑樹, 丹野寛大, 松永拓, 伊師森葉, 庄司未樹, 今井啓道, 菅野恵美

    日本創傷治癒学会プログラム・抄録集　54th　2024

  15. ATKパッドは創傷においてIL-6,VEGF産生及び肉芽形成を促進する

    伊藤永貴, 伊藤永貴, 佐藤佑樹, 鎌田若菜, 高屋敷玲奈, 曽根育恵, 曽根育恵, 川元詩穂, 今井利郎, 丹野寛大, 今井啓道, 菅野恵美

    日本創傷治癒学会プログラム・抄録集　54th　2024

  16. 乳酸菌Enterococcus faecalis KH2が熱傷治癒過程に与える影響

    曽根育恵, 佐藤佑樹, 今井利郎, 鎌田若奈, 高屋敷玲奈, 伊藤永貴, 川元詩穂, 丹野寛大, 菅野恵美

    日本創傷治癒学会プログラム・抄録集　54th　2024

  17. 過去の肥満が皮膚創傷治癒と皮膚免疫反応に与える影響

    鎌田若奈, 丹野寛大, 高屋敷玲奈, 伊藤永貴, 川元詩穂, 曽根育恵, 佐藤佑樹, 菅野恵美

    日本創傷治癒学会プログラム・抄録集　54th　2024

  18. C型レクチン受容体Dectin-1遺伝子欠損マウスにおける熱傷治癒促進機序の解析

    佐藤佑樹, 丹野寛大, 今井利郎, 鎌田若奈, 高屋敷玲奈, 伊藤永貴, 曽根育恵, 川元詩穂, 菅野恵美

    日本創傷治癒学会プログラム・抄録集　54th　2024

  19. 急性及び慢性創傷に対するハイドロゲル創傷被覆材ATKパッドの使用経験

    松永拓, 伊師森葉, 伊藤永貴, 今井利郎, 佐藤佑樹, 丹野寛大, 菅野恵美, 今井啓道

    日本創傷治癒学会プログラム・抄録集　54th　2024

  20. マウス熱傷創治癒におけるC型レクチン受容体Dectin-1の機能

    佐藤佑樹, 丹野寛大, 菅野恵美, 今井利郎

    熱傷(Web)　50　(4)　2024

    ISSN： 2435-1571

  21. バトロキソビンがマウス熱傷に与える影響の解析

    今井利郎, 佐藤佑樹, 丹野寛大, 松永拓, 伊師森葉, 庄司未樹, 今井啓道, 菅野恵美

    日本形成外科学会基礎学術集会プログラム・抄録集　33rd (CD-ROM)　2024

  22. マウス熱傷創治癒におけるC型レクチン受容体Dectin-1の機能

    佐藤佑樹, 今井利郎, 丹野寛大, 菅野恵美

    日本熱傷学会総会・学術集会プログラム・抄録集　50th　2024

  23. 殺菌乳酸菌Lactiplantibacillus plantarum KB131経口投与および局所投与がアトピー性皮膚炎マウスモデルに与える影響

    高屋敷玲奈, 丹野寛大, 佐藤佑樹, 菅野恵美

    日本食品免疫学会学術大会要旨集　20th　2024

  24. 肥満後の体重減少が皮膚免疫細胞に与える影響

    鎌田若奈, 丹野寛大, 高屋敷玲奈, 佐藤佑樹, 菅野恵美

    日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集　54th　2024

  25. 加熱殺菌乳酸菌Lactiplantibacillus plantarum KB131経口投与がアトピー性皮膚炎マウスモデルに与える影響

    高屋敷玲奈, 丹野寛大, 鎌田若奈, 佐藤佑樹, 菅野恵美

    日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集　54th　2024

  26. 加熱死菌Lactobacillus plantarumが皮膚創傷治癒過程に与える影響

    真壁風子, 伊師森葉, 丹野寛大, 小番冠奈, 今井啓道, 菅野恵美

    日本創傷・オストミー・失禁管理学会誌(Web)　27　(2)　2023

    ISSN： 1884-2321

  27. 加熱死菌Lactobacillus plantarumの創傷治癒促進機構におけるCARD9シグナルの関与

    小番冠奈, 伊師森葉, 丹野寛大, 真壁風子, 今井啓道, 菅野恵美

    日本創傷・オストミー・失禁管理学会誌(Web)　27　(2)　2023

    ISSN： 1884-2321

  28. マウス熱傷モデルの作成,および治癒過程におけるCARD9遺伝子欠損の影響

    佐藤佑樹, 今井利郎, 丹野寛大, 菅野恵美

    形態・機能　22　(1)　2023

    ISSN： 1347-7145

  29. 皮膚創傷治癒に対するバトロキソビンの影響-マウスモデルとHaCaT細胞での検討-

    鎌田若奈, 丹野寛大, 新井山ももこ, 佐藤佑樹, 菅野恵美

    形態・機能　22　(1)　2023

    ISSN： 1347-7145

  30. マウス熱傷治癒過程におけるDectin-1およびCARD9依存的免疫応答の解析

    佐藤佑樹, 今井利郎, 丹野寛大, 菅野恵美

    日本創傷治癒学会プログラム・抄録集　53rd　2023

  31. 加熱死菌乳酸菌Lactobacillus plantarumの創傷治癒促進過程におけるCARD9の関与

    伊師森葉, 丹野寛大, 小番冠奈, 真壁風子, 今井利郎, 庄司未樹, 今井啓道, 菅野恵美

    日本創傷治癒学会プログラム・抄録集　53rd　2023

  32. マウス熱傷モデル作成方法と経時的治癒過程

    今井利郎, 佐藤佑樹, 丹野寛大, 伊師森葉, 庄司未樹, 今井啓道, 菅野恵美

    日本創傷治癒学会プログラム・抄録集　53rd　2023

  33. ラット褥瘡モデルに対するEnterococcus faecalis KH2株局所投与の効果

    高屋敷玲奈, 丹野寛大, 佐藤佑樹, 小番冠奈, 真壁風子, 鎌田若奈, 菅野恵美

    日本創傷治癒学会プログラム・抄録集　53rd　2023

  34. Batroxobinが皮膚創傷治癒過程に与える影響-マウスモデルとヒトケラチノサイト株による検証-

    鎌田若奈, 丹野寛大, 新井山ももこ, 小番冠奈, 真壁風子, 高屋敷玲奈, 佐藤佑樹, 伊師森葉, 今井利郎, 今井啓道, 菅野恵美

    日本創傷治癒学会プログラム・抄録集　53rd　2023

  35. 病理組織学的経過からみたマウス熱傷治癒過程

    今井利郎, 佐藤佑樹, 丹野寛大, 伊師森葉, 庄司未樹, 今井啓道, 菅野恵美

    日本形成外科学会基礎学術集会プログラム・抄録集　32nd　2023

  36. Differences in clinicopathological characteristics between lipohypertrophy and localized insulin-derived amyloidosis: A scoping review International-journal

    Kanae Mukai, Hiromasa Tanno, Junko Sugama, Toshihiko Yanagita, Emi Kanno

    Chronic Diseases and Translational Medicine　10　(1)　22-30　2023

    DOI： 10.1002/cdt3.98 　

    eISSN： 2095-882X

  37. 創傷治癒へのC型レクチン受容体の関与

    丹野 寛大, 菅野 恵美

    BIO Clinica　37　(9)　870-873　2022/08

    Publisher: (株)北隆館

    ISSN： 0919-8237

  38. 【急性期褥瘡のアセスメントとケア-慢性化・重症化を防ぐために-】(Part 2)急性期褥瘡の特徴

    丹野 寛大, 菅野 恵美

    看護技術　68　(8)　736-742　2022/07

    Publisher: (株)メヂカルフレンド社

    ISSN： 0449-752X

  39. ヘビ毒由来酵素バトロキソビンによる新しい創傷ケア技術の開発に向けた実験的研究

    新井山ももこ, 丹野寛大, 黒坂志歩, 菅野恵美

    日本創傷・オストミー・失禁管理学会誌(Web)　26　(2)　2022

    ISSN： 1884-2321

  40. 乳酸菌Enterococcus faecalis KH2による創傷治癒促進へのDectin-2の関与

    小番冠奈, 丹野寛大, 黒坂志歩, 伊師森葉, 真壁風子, 川上和義, 菅野恵美

    日本創傷治癒学会プログラム・抄録集　52nd　2022

  41. バトロキソビン投与による皮膚創傷治癒促進機構の解明

    新井山ももこ, 丹野寛大, 伊師森葉, 小番冠奈, 真壁風子, 川上和義, 菅野恵美

    日本創傷治癒学会プログラム・抄録集　52nd　2022

  42. 急性創傷に対する高分散性乳酸菌Lactobacillus plantarumの創傷治癒誘導メカニズム

    伊師森葉, 菅野恵美, 丹野寛大, 今井利郎, 小番冠奈, 佐藤隼人, 新井山ももこ, 庄司未樹, 川上和義, 今井啓道

    日本創傷治癒学会プログラム・抄録集　52nd　2022

  43. 5-フルオロウラシル誘発性口腔粘膜潰瘍モデルの確立

    小番冠奈, 丹野寛大, 及川ゆかり, 才神利奈, 佐藤隼人, 川上和義, 菅野恵美

    日本看護技術学会学術集会講演抄録集　20th (CD-ROM)　2022

  44. ヘビ毒由来酵素バトロキソビンが皮膚創傷治癒に与える影響

    今井利郎, 菅野恵美, 丹野寛大, 新井山ももこ, 小番冠奈, 佐藤隼人, 伊師森葉, 庄司未樹, 川上和義, 今井啓道

    日本形成外科学会基礎学術集会プログラム・抄録集　31st　2022

  45. 高分散性乳酸菌Lactobacillus plantarumの創傷治癒促進効果

    伊師森葉, 菅野恵美, 丹野寛大, 今井利郎, 小番冠奈, 佐藤隼人, 新井山ももこ, 庄司未樹, 川上和義, 今井啓道

    日本形成外科学会基礎学術集会プログラム・抄録集　31st　2022

  46. 慢性創傷の創面環境調整(Wound bed preparation)達成に向けた乳酸菌の効果検証

    志済 真優, 丹野 寛大, 黒坂 志歩, 及川 ゆかり, 才神 利奈, 黒澤 佑太, 新井山 ももこ, 菅野 恵美

    日本看護科学学会学術集会講演集　41回　O23-01　2021/12

    Publisher: (公社)日本看護科学学会

  47. 慢性創傷に対する新規ケア技術の検証 ナチュラルキラーT細胞に注目して

    黒澤 佑太, 丹野 寛大, 黒坂 志歩, 及川 ゆかり, 志済 真優, 才神 利奈, 新井山 ももこ, 菅野 恵美

    日本看護科学学会学術集会講演集　41回　O23-02　2021/12

    Publisher: (公社)日本看護科学学会

  48. ヘビ毒由来酵素バトロキソビンによる新規創傷ケア技術の検証

    才神 利奈, 丹野 寛大, 新井山 ももこ, 黒坂 志歩, 及川 ゆかり, 黒澤 佑太, 志済 真優, 菅野 恵美

    日本看護科学学会学術集会講演集　41回　O23-03　2021/12

    Publisher: (公社)日本看護科学学会

  49. 乳酸菌Enterococcus faecalis KH2株を用いた創傷における新規ケア技術の検討

    黒坂 志歩, 丹野 寛大, 及川 ゆかり, 菅野 恵美

    日本創傷・オストミー・失禁管理学会誌　25　(2)　314-314　2021/07

    Publisher: (一社)日本創傷・オストミー・失禁管理学会

    ISSN： 1884-233X

    eISSN： 1884-2321

  50. 自然免疫リンパ球Natural Killer T細胞による新規創傷ケア技術の探索

    丹野 寛大, 黒坂 志歩, 及川 ゆかり, 菅野 恵美

    日本創傷・オストミー・失禁管理学会誌　25　(2)　315-315　2021/07

    Publisher: (一社)日本創傷・オストミー・失禁管理学会

    ISSN： 1884-233X

    eISSN： 1884-2321

  51. パターン認識受容体の役割に注目した皮膚創傷治癒ケア方法の検討 C型レクチン受容体に注目して

    及川 ゆかり, 丹野 寛大, 黒坂 志歩, 菅野 惠美

    日本創傷・オストミー・失禁管理学会誌　25　(2)　315-315　2021/07

    Publisher: (一社)日本創傷・オストミー・失禁管理学会

    ISSN： 1884-233X

    eISSN： 1884-2321

  52. 【創傷における感染対策〜この10年で何が変わったか〜】創傷における感染防御機構、影響を与える要因

    丹野 寛大, 菅野 恵美

    WOC Nursing　9　(4)　4-11　2021/04

    Publisher: (株)医学出版

  53. 【創傷における感染対策〜この10年で何が変わったか〜】Wound hygiene(ウンドハイジーン)の概念

    菅野 恵美, 丹野 寛大

    WOC Nursing　9　(4)　12-17　2021/04

    Publisher: (株)医学出版

  54. Dectin-2シグナルを介した皮膚創傷治癒遅延へのNatural Killer T細胞欠損の影響

    丹野 寛大, 菅野 恵美, 佐々木 綾子, 黒坂 志歩, 及川 ゆかり, 石井 恵子, 川上 和義, 館 正弘

    日本創傷治癒学会プログラム・抄録集　50回　70-70　2020/11

    Publisher: (一社)日本創傷治癒学会

  55. 創傷治癒におけるDectin-1,2発現細胞と創部上清中リガンドの検証

    及川 ゆかり, 菅野 惠美, 山口 賢次, 丹野 寛大, 後藤 友華, 黒坂 志歩, 川上 和義, 館 正弘

    日本創傷治癒学会プログラム・抄録集　50回　71-71　2020/11

    Publisher: (一社)日本創傷治癒学会

  56. 乳酸菌Enterococcus faecalis KH2株が皮膚創傷治癒に与える影響

    黒坂 志歩, 丹野 寛大, 菅野 恵美, 及川 ゆかり, 石井 恵子, 川上 和義, 館 正弘

    日本創傷治癒学会プログラム・抄録集　50回　75-75　2020/11

    Publisher: (一社)日本創傷治癒学会

  57. 創傷治癒学のブレイクスルー 創傷治癒機構に対する宿主免疫に注目して 看護学、形成外科学、免疫学の融合

    丹野 寛大

    日本創傷治癒学会プログラム・抄録集　49回　81-81　2019/12

    Publisher: (一社)日本創傷治癒学会

  58. 皮膚創傷治癒におけるDectin-1,2の役割とNETs形成との関連

    山口 賢次, 川上 和義, 菅野 恵美, 佐々木 綾子, 庄司 未樹, 三浦 孝行, 丹野 寛大, 高木 尚之, 今井 啓道, 館 正弘

    日本創傷治癒学会プログラム・抄録集　49回　108-108　2019/12

    Publisher: (一社)日本創傷治癒学会

  59. バイオフィルムに対する治療・ケア-新規ターゲットの可能性

    菅野恵美, 川上和義, 川上和義, 丹野寛大, 山口賢次, 館正弘

    日本形成外科学会基礎学術集会プログラム・抄録集　28th　2019

  60. 【創傷治癒の最前線】急性創傷と慢性創傷の治癒過程

    丹野 寛大, 菅野 恵美

    WOC Nursing　6　(7)　5-12　2018/07

    Publisher: (株)医学出版

  61. 【創傷治癒の最前線】 急性創傷と慢性創傷の治癒過程

    丹野 寛大, 菅野 恵美

    WOC Nursing　6　(7)　5-12　2018/07

    Publisher: (株)医学出版

  62. 皮膚創傷治癒に関するDectin-1,2シグナルの好中球性炎症反応に注目した解析

    山口賢次, 川上和義, 菅野恵美, 佐々木綾子, 庄司未樹, 三浦孝行, 丹野寛大, 高木尚之, 館正弘

    日本形成外科学会基礎学術集会プログラム・抄録集　27th　2018

  63. 創傷治癒と細菌感染 (特集 創部感染の予防とケア)

    丹野 寛大, 菅野 恵美

    看護技術　63　(9)　830-834　2017/08

    Publisher: メヂカルフレンド社

    ISSN： 0449-752X

  64. 皮膚創部への好中球集積と炎症反応のNKT細胞による制御

    山口賢次, 丹野寛大, 菅野恵美, 三浦孝行, 石井恵子, 川上和義, 館正弘

    日本形成外科学会基礎学術集会プログラム・抄録集　26th　2017

  65. IL‐17Aは好中球性炎症反応を遷延させ急性創傷治癒の遅延に働く

    菅野恵美, 高木尚之, 丹野寛大, 石井恵子, 丸山良子, 岩倉洋一郎, 館正弘, 川上和義

    日本生体防御学会学術総会講演抄録集　28th　49　2017

  66. NKT細胞は好中球性炎症を制御し皮膚創傷治癒を促進する

    丹野寛大, 菅野恵美, 三浦孝之, 石井恵子, 中山俊憲, 谷口克, 丸山良子, 館正弘, 川上和義

    日本生体防御学会学術総会講演抄録集　28th　48　2017

  67. LACK OF NKT CELLS LEADS TO PERSISTED INFILTRATION OF NEUTROPHILS AND DELAYED WOUND HEALING PROCESS IN SKIN

    H. Tanno, K. Kawakami, E. Kanno, A. Suzuki, N. Takagi, R. Kamimatsuno, K. Ishii, R. Maruyama, M. Tachi

    WOUND REPAIR AND REGENERATION　24　(4)　A38-A38　2016/07

    ISSN： 1067-1927

    eISSN： 1524-475X

  68. EFFECT OF CARD9-DEFICIENCY ON THE WOUND HEALING PROCESS IN SKIN

    A. Suzuki, E. Kanno, K. Kawakami, H. Tanno, R. Kamimatsuno, N. Takagi, K. Ishii, R. Maruyama, M. Tachi

    WOUND REPAIR AND REGENERATION　24　(4)　A38-A38　2016/07

    ISSN： 1067-1927

    eISSN： 1524-475X

  69. INVOLVEMENT OF TYPE I INTERFERON ON THE WOUND HEALING IN SKIN

    R. Kamimatsuno, E. Kanno, K. Kawakami, H. Tanno, A. Suzuki, N. Takagi, K. Ishii, R. Maruyama, M. Tachi

    WOUND REPAIR AND REGENERATION　24　(4)　A39-A39　2016/07

    ISSN： 1067-1927

    eISSN： 1524-475X

  70. PSEUDOMONAS AERUGINOSA CONTRIBUTES TO APOPTOSIS INDUCTION ON THE WOUND SITES

    E. Kanno, K. Kawakami, H. Tanno, A. Suzuki, R. Kamimatsuno, K. Ishii, N. Takagi, R. Maruyama, M. Tachi

    WOUND REPAIR AND REGENERATION　24　(4)　A41-A41　2016/07

    ISSN： 1067-1927

    eISSN： 1524-475X

  71. 創傷治癒の基礎 創傷における炎症反応の新たな知見 急性創傷におけるCARD9の役割

    丹野 寛大

    日本褥瘡学会誌　17　(3)　299-299　2015/07

    Publisher: (一社)日本褥瘡学会

    ISSN： 1345-0417

  72. 緑膿菌が創部アポトーシス誘導に与える影響

    菅野恵美, 川上和義, 丹野寛大, 丹野寛大, 鈴木愛子, 上松野りな, 石井恵子, 高木尚之, 丸山良子, 館正弘

    東北医学雑誌　127　(1)　91　2015/06/25

    ISSN： 0040-8700

  73. NKT細胞及び好中球性炎症制御による創傷治癒促進と免疫機構の解明

    高木尚之, 丹野寛大, 川上和義, 菅野恵美, 上松野りな, 武田睦, 石井恵子, 館正弘

    日本形成外科学会基礎学術集会プログラム・抄録集　24th　2015

  74. マウス創傷治癒過程におけるCARD9遺伝子欠損の影響

    上松野りな, 鈴木愛子, 菅野恵美, 丹野寛大, 丹野寛大, 高木尚之, 石井恵子, 原博満, 丸山良子, 川上和義, 館正弘

    日本生体防御学会学術総会講演抄録集　26th　56　2015

  75. NKT細胞による好中球性炎症反応の制御を介した皮膚創傷治癒の促進

    丹野寛大, 丹野寛大, 菅野恵美, 鈴木愛子, 高木尚之, 上松野りな, 石井恵子, 岩倉洋一郎, 中山俊憲, 谷口克, 丸山良子, 川上和義, 館正弘

    日本生体防御学会学術総会講演抄録集　26th　60　2015

  76. CARD9 DOES NOT AFFECT ACUTE WOUND HEALING

    A. Suzuki, E. Kanno, K. Kawakami, H. Tanno, K. Ishii, R. Maruyama, M. Tachi

    WOUND REPAIR AND REGENERATION　22　(2)　A61-A61　2014/03

    ISSN： 1067-1927

    eISSN： 1524-475X

  77. INVOLVEMENT OF INVARIANT NATURAL KILLER T CELLS IN THE ACUTE WOUND HEALING IN SKIN

    H. Tanno, K. Kawakami, E. Kanno, A. Suzuki, K. Ishii, R. Maruyama, M. Tachi

    WOUND REPAIR AND REGENERATION　22　(2)　A61-A61　2014/03

    ISSN： 1067-1927

    eISSN： 1524-475X

  78. PROMOTION OF ACUTE WOUND HEALING BY N-BUTANOYL-(L)-HOMOSERINE LACTONE FROM PSEUDOMONAS AERUGINOSA

    E. Kanno, H. Tanno, K. Kawakami, S. Miyairi, K. Ishii, R. Maruyama, M. Tachi

    WOUND REPAIR AND REGENERATION　22　(1)　A8-A8　2014/01

    ISSN： 1067-1927

    eISSN： 1524-475X

  79. 創傷治癒過程におけるサイトカイン,ケモカイン産生とNKT細胞の関与

    丹野寛大, 川上和義, 鈴木愛子, 菅野恵美, 高木尚之, 上松野りな, 石井恵子, 丸山良子, 館正弘

    日本生体防御学会学術総会講演抄録集　25th　21　2014

  80. 創傷治癒におけるIL-17欠損の影響に関する研究

    高木 尚之, 川上 和義, 丹野 寛大, 菅野 恵美, 石井 恵子, 館 正弘

    日本創傷治癒学会プログラム・抄録集　43回　125-125　2013/11

    Publisher: (一社)日本創傷治癒学会

  81. ROLE OF INVARIANT NATURAL KILLER T CELL IN SKIN WOUND HEALING

    H. Tanno, K. Kawakami, E. Kanno, K. Ishii, D. Hayashi, R. Maruyama, M. Tachi

    WOUND REPAIR AND REGENERATION　21　(1)　A9-A9　2013/01

    ISSN： 1067-1927

  82. 皮膚創傷治癒過程におけるCARD9遺伝子欠損の影響に関する研究

    鈴木愛子, 菅野恵美, 川上和義, 丹野寛大, 上松野りな, 石井恵子, 丸山良子, 館正弘

    日本創傷治癒学会プログラム・抄録集　43rd　123-123　2013

    Publisher: (一社)日本創傷治癒学会

  83. 創傷治癒過程におけるサイトカイン,ケモカイン産生とNKT細胞の関与

    丹野寛大, 川上和義, 鈴木愛子, 中山史子, 菅野恵美, 高木尚之, 石井恵子, 古和田雪, 丸山良子, 館正弘

    日本創傷治癒学会プログラム・抄録集　43rd　126-126　2013

    Publisher: (一社)日本創傷治癒学会

  84. 緑膿菌クオラムセンシング分子N‐butanoyl‐L‐homoserine lactoneが創傷治癒過程と創部炎症反応に与える影響

    鈴木愛子, 菅野恵美, 川上和義, 宮入伸一, 丹野寛大, 石井恵子, 丸山良子, 館正弘

    日本生体防御学会学術総会講演抄録集　24th　55　2013

  85. マウス皮膚創傷治癒過程とNatural Killer T細胞:IFN‐γとIL‐4の関与について

    丹野寛大, 川上和義, 立雅恵, 菅野恵美, 石井恵子, 林殿聡, 丸山良子, 館正弘

    日本創傷治癒学会プログラム・抄録集　42nd　126-126　2012

    Publisher: (一社)日本創傷治癒学会

  86. マウス皮膚創傷治癒過程におけるNatural Killer T細胞とIFN‐γ,IL‐4の役割

    丹野寛大, 川上和義, 立雅恵, 菅野恵美, 林殿聡, 石井恵子, 丸山良子, 館正弘

    日本生体防御学会学術総会講演抄録集　23rd　44　2012

  87. 緑膿菌クオラムセンシング分子N‐butanoyl‐L‐homoserine lactoneが創傷治癒過程に与える影響

    菅野恵美, 丹野寛大, 川上和義, 宮入伸一, 石井恵子, 丸山良子, 館正弘

    日本創傷治癒学会プログラム・抄録集　42nd　109-109　2012

    Publisher: (一社)日本創傷治癒学会

  88. 緑膿菌PAO1株接種による創傷治癒の促進 創部に集積した好中球の役割

    菅野 恵美, 川上 和義, 丹野 寛大, 石井 恵子, 林 殿聡, 丸山 良子, 館 正弘

    形態・機能　10　(1)　39-39　2011/08

    Publisher: コ・メディカル形態機能学会

    ISSN： 1347-7145

    eISSN： 1884-6084

  89. 緑膿菌クオラムセンシング機構が創傷治癒過程と創部炎症反応に与える影響

    菅野恵美, 川上和義, 乙丸礼乃, 石井恵子, 丹野寛大, 林殿総, 丸山良子, 館正弘

    日本じょくそう学会誌　13　(3)　452-452　2011/07/20

    Publisher: (一社)日本褥瘡学会

    ISSN： 1345-0417

  90. マウス皮膚創傷治癒におけるNatural Killer T細胞の役割

    丹野寛大, 川上和義, 立雅恵, 菅野恵美, 石井恵子, 林殿聡, 丸山良子, 館正弘

    日本じょくそう学会誌　13　(3)　454-454　2011/07/20

    Publisher: (一社)日本褥瘡学会

    ISSN： 1345-0417

  91. マウス皮膚創傷治癒過程におけるNatural Killer T細胞とIFN‐γの役割

    丹野寛大, 川上和義, 立雅恵, 菅野恵美, 林殿聡, 石井恵子, 丸山良子, 館正弘

    日本生体防御学会学術総会講演抄録集　22nd　28　2011

  92. 緑膿菌クオラムセンシング分子N‐3‐Oxododecanoyl‐homoserine lactoneが創傷治癒過程と創部炎症反応に与える影響

    菅野恵美, 川上和義, 乙丸礼乃, 石井恵子, 丹野寛大, 林殿聡, 丸山良子, 館正弘

    日本生体防御学会学術総会講演抄録集　22nd　49　2011

  93. マウス皮膚創傷治癒過程におけるNatural Killer T細胞の役割

    丹野寛大, 川上和義, 立雅恵, 菅野恵美, 石井恵子, 林殿聡, 丸山良子, 館正弘

    日本創傷治癒学会プログラム・抄録集　41st　69-69　2011

    Publisher: (一社)日本創傷治癒学会

  94. 緑膿菌クオラムセンシング分子による創傷治癒の促進と創部炎症反応の誘導

    菅野恵美, 川上和義, 乙丸礼乃, 石井恵子, 丹野寛大, 林殿聡, 丸山良子, 館正弘

    日本創傷治癒学会プログラム・抄録集　41st　64-64　2011

    Publisher: (一社)日本創傷治癒学会

  95. マウス皮膚創傷治癒過程におけるTNF‐αとinvariant natural killer T細胞の役割

    丹野寛大, 川上和義, 立雅恵, 菅野恵美, 石井恵子, 林殿聡, 丸山良子, 館正弘

    日本生体防御学会学術総会講演抄録集　21st　36　2010

  96. 創傷治癒過程における緑膿菌接種の影響:集積した好中球によるTNF‐α産生に注目して

    菅野恵美, 川上和義, 石井恵子, 立雅恵, 丹野寛大, 鳥谷部荘八, 林殿聡, 丸山良子, 館正弘

    日本生体防御学会学術総会講演抄録集　21st　60　2010

  97. マウス皮膚創傷治癒過程におけるNatural Killer T細胞の役割とその作用におけるTNF‐αの関与

    丹野寛大, 川上和義, 立雅恵, 菅野恵美, 石井恵子, 林殿聡, 丸山良子, 館正弘

    日本創傷治癒学会プログラム・抄録集　40th　60-60　2010

    Publisher: (一社)日本創傷治癒学会

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Books and Other Publications 1

  1. 看護技術2017年8月号

    丹野 寛大, 菅野 恵美

    メヂカルフレンド社　2017/07

Presentations 12

  1. 創傷治癒機構に対する宿主免疫に注目して～看護学、形成外科学、免疫学の融合～ Invited

    丹野寛大

    第49回日本創傷治癒学会 シンポジウム6 創傷治癒学のブレイクスルー

  2. 皮膚創傷におけるDectin-2シグナルを介した治癒過程及びNETosisの制御

    三浦 孝行, 川上 和義, 菅野 恵美, 丹野 寛大, 多田 浩之, 佐藤 紀子, 正木 愛梨, 高木 尚之, 山口 賢次, 石井 恵子, 館 正弘

    日本創傷治癒学会プログラム・抄録集　2017/11

  3. マウス皮膚創傷治癒過程におけるMincle遺伝子欠損の影響

    佐藤 紀子, 菅野 恵美, 丹野 寛大, 正木 愛梨, 高木 尚之, 石井 恵子, 丸山 良子, 川上 和義, 館 正弘

    日本創傷治癒学会プログラム・抄録集　2017/11

  4. 創傷治癒過程におけるインターフェロンγ欠損の影響

    正木 愛梨, 菅野 恵美, 丹野 寛大, 佐藤 紀子, 三浦 孝行, 山口 賢次, 石井 恵子, 川上 和義, 館 正弘

    日本創傷治癒学会プログラム・抄録集　2017/11

  5. 皮膚創傷治癒過程におけるNKT細胞の役割 好中球性炎症に注目して

    丹野 寛大, 菅野 恵美, 佐藤 紀子, 正木 愛梨, 三浦 孝行, 山口 賢次, 石井 恵子, 丸山 良子, 川上 和義, 館 正弘

    日本創傷治癒学会プログラム・抄録集　2017/11

  6. 創傷感染管理の最前線 Biofilm-based wound therapy バイオフィルムに対する治療・ケア 何をターゲットとするべきか?

    菅野 恵美, 川上 和義, 丹野 寛大, 山口 賢次, 館 正弘

    日本創傷治癒学会プログラム・抄録集　2017/11

  7. マウス皮膚創傷治癒過程におけるMincle遺伝子欠損の影響

    佐藤 紀子, 菅野 恵美, 丹野 寛大, 正木 愛梨, 高木 尚之, 石井 恵子, 丸山 良子, 川上 和義, 館 正弘

    日本創傷治癒学会プログラム・抄録集　2016/12

  8. マウス皮膚創傷治癒過程におけるインターフェロン-γの影響に関する研究

    正木 愛梨, 菅野 恵美, 丹野 寛大, 佐藤 紀子, 石井 恵子, 丸山 良子, 川上 和義, 館 正弘

    日本創傷治癒学会プログラム・抄録集　2016/12

  9. NKT細胞の活性化が創傷治癒過程に与える影響 α-GalCer創部投与による検証

    丹野 寛大, 川上 和義, 菅野 恵美, 今村 彩乃, 佐藤 紀子, 正木 愛梨, 高木 尚之, 石井 恵子, 丸山 良子, 館 正弘

    日本創傷治癒学会プログラム・抄録集　2016/12

  10. マウス皮膚創傷治癒過程におけるCARD9を介したシグナル伝達の影響

    菅野 恵美, 川上 和義, 丹野 寛大, 鈴木 愛子, 佐藤 紀子, 正木 愛梨, 高木 尚之, 石井 恵子, 丸山 良子, 館 正弘

    日本創傷治癒学会プログラム・抄録集　2016/12

  11. Invariant Natural Killer T cells: Roles in skin wound healing and potential clinical application. Invited

    Hiromasa Tanno

    The 10th Congress of Chinese Tissue Repair Society

  12. Invariant Natural Killer T cells: Roles in skin wound healing and potential clinical application. Invited

    Hiromasa Tanno

    The 13th Japan-Korea Congress of Plastic and Reconstructive Surgery

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Industrial Property Rights 5

  1. 皮膚塗布用の皮膚創傷治癒促進組成物、その製造方法、及び創傷被覆材

    菅 辰彦, 渡邉 卓巳, 菅野 恵美, 川上 和義, 丹野 寛大, 館 正弘

    特許第7045671号

    Property Type: Patent

  2. 消化管障害抑制用組成物

    渡邉 卓巳, 生天目 由里子, 菅野 恵美, 川上 和義, 丹野 寛大

    Property Type: Patent

  3. 皮膚塗布用の皮膚創傷治癒促進組成物、その製造方法、及び創傷被覆材

    菅 辰彦, 渡邉 卓巳, 菅野 恵美, 川上 和義, 丹野 寛大, 館 正弘

    Property Type: Patent

  4. 皮膚塗布用の皮膚創傷治癒促進組成物、その製造方法、及び創傷被覆材

    菅 辰彦, 渡邉 卓巳, 菅野 恵美, 川上 和義, 丹野 寛大, 館 正弘

    Property Type: Patent

  5. 皮膚損傷治癒の促進剤

    菅野 恵美, 川上 和義, 館 正弘, 丹野 寛大

    Property Type: Patent

Research Projects 29

  1. 免疫制御による複数の創傷難治化要因を包括的に解決するユニバーサル創傷ケアの開発

    丹野 寛大

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2026/04/01 - 2029/03/31

  2. 肥満改善後も持続する創傷難治化：肥満が皮膚に刻む「肥満メモリー」リセット法の探索

    丹野 寛大

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 挑戦的研究(萌芽)

    Institution: 東北大学

    2026/06/26 - 2028/03/31

  3. 皮膚の常在菌を活用したアトピー性皮膚炎のバリア機能を高める革新的技術の創出

    菅野 恵美, 丹野 寛大, 佐藤 佑樹, 庄司 未樹

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 挑戦的研究(萌芽)

    Institution: 東北大学

    2025/06/27 - 2027/03/31

  4. 肥満改善後も慢性炎症を増悪させる肥満メモリー免疫細胞の探索と創傷難治化への関与

    丹野 寛大, 菅野 恵美, 佐藤 佑樹, 伊師 森葉, 庄司 未樹

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 挑戦的研究(萌芽)

    Institution: 東北大学

    2024/06/28 - 2026/03/31

  5. 熱傷治療に新たな選択肢を-感染制御と上皮化誘導を両立するナノ型乳酸菌-

    山口 賢次, 菅野 恵美, 丹野 寛大, 佐藤 光, 工藤 大介, 今井 啓道, 庄司 未樹

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2023/04/01 - 2026/03/31

    More details Close

    本年度は急性創傷におけるナノ型乳酸菌の効果の検証と熱傷創モデルの確立を中心に研究を進めた。 急性創傷におけるナノ型乳酸菌の効果に関しては、直接投与の濃度を検証し、さらに初回単回投与での創閉鎖率の改善を認めた。加えて、病理学的解析においても、CD31陽性血管数やαSMA陽性筋繊維芽細胞数の増加を認め、創傷治癒に関わる肉芽の増生を認めた。上皮化に関しても、上皮の進展率の上昇を認め、増生した肉芽上に皮膚が進展し、治癒が促進していることを確認できた。 急性期において炎症の調節に必要なサイトカインに関してELISA法での解析を行ったところ、IL-6やTNF-αの早期での上昇を認めた。加えて、好中球の遊走に関与するCXCL2やCXCL1なども著明な上昇を認めた。これらは、乳酸菌を急性創傷に投与することで創部における炎症が惹起され、創傷治癒過程における炎症期のメカニズムと合致する。炎症を惹起することで創の清浄化が促進する可能性が示唆された。さらに、抗炎症に作用するI L-10も後期にて上昇を認めた。炎症期から増殖期への移行を適切にかつ早期に誘導することで、創傷治癒を早めている可能性がある。今後、フローサイトメトリーで創部に遊走される白血球の分画を解明し、創傷治癒過程の変化を観察する予定である。 熱傷創モデルに関しては、マウス背部に電気ごてで作成した熱傷創の治癒過程及び病理学的変化を解析した。熱傷創が治癒する過程と、温度による変化、保護剤による違いなどを検討している。今後、標準的な治癒過程を明らかにし、ナノ型乳酸菌投与による変化を比較検討していく予定である。

  6. 「食べる」を支える、がん治療に伴う粘膜障害に対する新規ケア法の創出

    菅野 恵美, 丹野 寛大, 佐藤 佑樹, 佐藤 光, 庄司 未樹

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2024/04/01 - 2025/03/31

  7. 消化管をケアし、がん治療に伴う栄養障害を改善する革新的技術の創出

    菅野 恵美, 丹野 寛大, 佐藤 佑樹, 佐藤 光, 庄司 未樹

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 挑戦的研究(萌芽)

    Institution: 東北大学

    2023/06/30 - 2025/03/31

  8. 「食べる」を支える、がん治療に伴う粘膜障害に対する新規ケア法の創出

    菅野 恵美, 丹野 寛大, 佐藤 光, 庄司 未樹

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(B)

    Category: 基盤研究(B)

    Institution: 東北大学

    2022/04/01 - 2025/03/31

  9. Snake venom heals wounds -Inhibition of NETs by batroxobin and induction of CD34positive cells-

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2022/04/01 - 2025/03/31

  10. Development of protamine-containing wound dressing for diabetic foot gangrene

    Umeyama Hirokatsu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2021/04/01 - 2024/03/31

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    The wound healing promoting effect of protamine, a substance derived from salmon milt, was examined. The cytokine release and changes in cell number induced by protamine administration in cultured cells were examined in detail. The involvement of cytokine induction not only in mouse macrophages but also in dendritic cell stimulation was suggested, and the lipopolysaccharide in the protamine formulation used may be involved, and the effect was examined in an endotoxin inactivation experiment using polymyxin B. As a result, no induction of inflammation was observed with protamine alone, suggesting the possibility that the substances contained in the product promote healing.

  11. Development of Novel Universal Wound Care by Inhibition of "Neutrophil Extracellular Trap" for Chronic Wounds

    Tanno Hiromasa

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2021/04/01 - 2024/03/31

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    Chronic wounds are intractable due to the combined effects of biofilm formation and impaired blood flow. However, there is no universal wound care that can simultaneously approach multiple causes. In this study, we aimed to establish universal wound care by elucidating the effect of defibrase, which has already been shown to inhibit neutrophil extracellular trapping, on wound healing. Using acute and chronic wound models, we analyzed the effects of defibrase on wound healing and found that defibrase promotes wound healing by analyzing wound closure rate, re-epithelialization rate, granulation area, and angiogenesis.

  12. Analysis of wound healing responses through skin-intestine networks

    Kanno Emi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Research (Exploratory)

    Institution: Tohoku University

    2021/07/09 - 2023/03/31

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    The purpose of our study is to develop an “innovative wound care using heat-killed nano-type lactic acid bacteria (nano-type LAB) through skin-intestine networks”. We analyzed villus length, the Foxp3 positive cells and IL-10 positive cells in small intestine after oral administration of nano-type LAB in immunosuppressive mice. We found that nano-type LAB contributed to increased villus length, Foxp3 positive cells and IL-10 positive cells. Thus, we concluded that heat-killed nano-type LAB may be involved in controlling intestional conditions by anti-inflammatory activity.

  13. The crosstalk between bacterial communities and biofilm formation

    Shimodera Saeko

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2020/04/01 - 2023/03/31

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    The purpose of our study is to elucidate the crosstalk between bacterial communities and biofilm formation. N-(3-Oxododecanoyl)-L-homoserine lactone (3-oxo-C12-HSL) is synthesized by an autoinducer synthase encoded by the bacterial lasI gene in P. aeruginosa, which regulates the production of virulence factors and biofilm formation in this bacterium. Wounds were created on the backs of Sprague-Dawley (SD) rats and 3-oxo-C12-HSL was administered on to the wound surface. Administration of 3-oxo-C12-HSL significantly promoted wound healing and neutrophil accumulation, and these responses were reversed by treatment with anti-3-oxo-C12-HSL antiserum. These results suggest that 3-oxo-C12-HSL may be involved in biofilm formation through inflammatory response such as neutrophil accumulation.

  14. Development of immunotherapy through C-type lectin receptors for chronic wounds

    TACHI Masahiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2019/04/01 - 2022/03/31

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    C-type lectin receptors (CLRs) recognize microbial polysaccharides. The precise roles of these CLRs in wound healing remain unclear. This study was conducted to determine the roles of Dectin-1 and Dectin-2 in wound healing, with a particular focus on the kinetics of neutrophilic inflammatory response. Wounds were created on the backs of C57BL/6 mice, and the effects of Dectin-1 or Dectin-2 deficiency. We also analyzed wound closure, histological findings, and neutrophilic inflammatory response, including neutrophil extracellular trap formation. We found that Dectin-1 contributed to the acceleration of wound healing by inducing early-phase neutrophil accumulation, whereas Dectin-2 was involved in prolonged neutrophilic responses and neutrophil extracellular trap formation, leading to delayed wound healing. These results suggest that Dectin-1 and Dectin-2 have different roles in wound healing through their different effects on the neutrophilic response.

  15. Development of wound care for regulating inflammatory responses using nano-type lactic acid bacteria

    Kanno Emi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2019/04/01 - 2022/03/31

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    The purpose of our study is to develop an “innovative skin wound care using nano-type lactic acid bacteria (heat-killed KH2).” We analyzed percent wound closure and granulation area. We found that heat-killed KH2 contributed to the acceleration of the formation of granulation tissue by inducing tumor necrosis factor-α, interleukin-6, basic fibroblast growth factor, transforming growth factor (TGF)-β1 production. In addition, heat-killed KH2 also improved wound closure, which was accompanied by the increased production of TGF-β1 in diabetic mice. Topical administration of heat-killed KH2 might have therapeutic potential for the treatment of chronic skin wounds in diabetes mellitus. In the present study, we concluded that heat-killed KH2 promoted skin wound-healing through the formation of granulation tissues and the production of inflammatory cytokines and growth factors.

  16. Contribution of invariant natural killer T cells and IFN-gamma to neutrophilic inflammation in skin wounds

    Kanno Emi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)

    Category: Grant-in-Aid for Challenging Research (Exploratory)

    Institution: Tohoku University

    2019/06/28 - 2021/03/31

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    Interferon (IFN)-γ is mainly secreted by CD4+ T helper 1 (Th1), natural killer (NK) and NKT cells after skin injury. Although IFN-γ is well known regarding its inhibitory effects on collagen synthesis by fibroblasts in vitro,information is limited regarding its role in wound healing in vivo.In the present study, we analyzed how the defect of IFN-γ affects wound healing. Full-thickness wounds were created on the backs of wild type (WT) C57BL/6 and IFN-γ-deficient (KO) mice. We analyzed the percent wound closure, accumulation of leukocytes, and matrix metalloproteinases (MMPs). IFN-γKO mice exhibited significant attenuation in wound closure on Day 10, characteristics that are associated with prolonged neutrophil accumulation. Expression levels of MMP-2 mRNA were significantly greater in IFN-γKO than in WT. Moreover, under neutropenic conditions created with anti-Gr-1 monoclonal antibodies, wound closure in IFN-γKO mice was recovered through low MMP-2 expression levels.

  17. Development of a novel approach for infected wounds focusing on lymphocyte function

    Tanno Hiromasa

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists

    Category: Grant-in-Aid for Early-Career Scientists

    Institution: Tohoku University

    2019/04/01 - 2021/03/31

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    Bacteria are detected in more than 90% of chronic wounds such as pressure ulcers and diabetic leg ulcers, and Pseudomonas aeruginosa is one of the most frequently detected bacteria. In this study, we analyzed the effect of NKT cell activation on the elimination of P. aeruginosa in wounds. Administration of α-GalCer, a specific activator of NKT cells, resulted in significantly decreased the number of live colonies in the wounded tissues on days 5 and 7 after P. aeruginosa inoculation, and significantly increased the number of neutrophils on day 3. IFN-γ, IL-22, IL-23, IL-12p70, and S100A9 production were significantly higher in α-GalCer-treated group than in vehicle-treated group. These results suggest that iNKT cells promote P. aeruginosa clearance during skin wound healing.

  18. Contribution of C-type lectin receptor-mediated signaling to neutrophil extracellular traps in skin ulcers

    Akiko Yano

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2018/04/01 - 2021/03/31

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    C-type lectin receptors recognize microbial polysaccharides. The C-type lectin receptors such as dendritic cell-associated C-type lectin (Dectin)-1 and Dectin-2, which are triggered by β-glucan and α-mannan, respectively, contribute to upregulation of the inflammatory response. This study was conducted to determine the roles of Dectin-1 and Dectin-2 in skin wound healing, with a particular focus on the kinetics of neutrophilic inflammatory response. Full-thickness wounds were created on the backs of C57BL/6 mice, and the effects of Dectin-1 or Dectin-2 deficiency and those of β-glucan or α-mannan administration were examined. We also analyzed wound closure, histological findings, and neutrophilic inflammatory response, including neutrophil extracellular trap formation. We found that Dectin-2 was involved in prolonged neutrophilic responses and neutrophil extracellular trap formation, leading to delayed wound healing.

  19. Involvement of NETosis on the diabetic ulcers and development of novel wound care

    Tachi Masahiro, KAWAKAMI kazuyoshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)

    Category: Grant-in-Aid for Challenging Research (Exploratory)

    Institution: Tohoku University

    2017/06/30 - 2019/03/31

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    It is well known about immunocompromised state and neutrophil dysfunction in diabetic foot ulcers. But the detailed mechanism of neutrophil dysfunction remains unclear. In the current study, to identify the possible contribution of NETosis the co-localization between Ly6G (marker of neutrophils) and citrullinated histon (an indicator of NETosis) and elastase activity after α-mannan administration were examined. We discovered that the expression of citrullinated histone was accerated at the wound sites. In addition, elastase activity level was significantly higher in α-mannan-administrated mice than in vehicle-administered mice. We next investigated the effect of sivelestat sodium, a neutrophil elastase inhibitor, on wound closure in WT mice administered α-mannan, and the administration of sivelestat sodium was found to significantly improve the delayed wound closure caused by α-mannan.

  20. The right lateral decubitus position may attenuate sympathetic nervous activity in elderly adults

    Maruyama Ryoko, HOSHI Junko, SUN Xinru

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)

    Category: Grant-in-Aid for Challenging Research (Exploratory)

    Institution: Tohoku University

    2017/06/30 - 2019/03/31

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    This study was to evaluate the effect of the spine, left lateral decubitus, and right lateral decubitus position on autonomic nervous activity elderly by using spectral analysis heart rate variability (HRV). Forty-five elderly adults were enrolled. The lowest heart rate continued for 10 min, when participants were left lateral decubitus position on compared with the other two positions, The low frequency HRV to high-frequency HRV ratio (LF/HF) for the right lateral decubitus position was significantly lower than that for the other position. The right lateral decubitus position may attenuate sympathetic nerve activity in elder adults.

  21. Establishment of new wound care for chronic wound with infection by analysing lymphocyte function

    Tanno Hiromasa

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2017/04/01 - 2019/03/31

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    Chronic wound infections are considered one of the most severe wound problem. Indeed, some studies reported bacteria are present over 90 % of chronic wounds. Pseudomonas aeruginosa is frequently isolated from chronic wounds and thought to be a cause of delayed wound healing. Previously, we showed that iNKT cell deficiency resulted in a delayed wound healing process. Other group showed that NKT cells enhanced pulmonary clearance of this bacteria. However, the role of NKT cells in the host defense to P. aeruginosa infection at the wound sites remains to be elucidated. In this study, we conducted to elucidate the role of NKT cells in the host defense to P. aeruginosa infection at the wound site. NKT cells promote re-epithelialization and P. aeruginosa clearance during wound healing. This mechanism may be associated with increased levels of IL-17A and β-defensin1.

  22. Development of innovative wound care using applied immune regulation on chronic wounds

    Tachi Masahiro, KAZAMA itsurou

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

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    In chronic wounds, the inflammatory responses are prolonged with persistent neutrophil infiltration. Recently, we showed that skin wound healing was delayed and the healing process was impaired under conditions lacking invariant natural killer T (iNKT) cells, an innate immune lymphocyte with potent immuno-regulatory activity. In the present study, to identify the possible contribution of NKT cells activation, the effects of α-Galactosylceramide (α-GalCer) administration on wound healing, specific activator of iNKT cells, were examined. Administration of a-GalCer at the wound sites significantly promoted wound closure, granulation tissue formation, angiogenesis compared with vehicle treatment. In addition, the inflammatory cells were rapidly decreased and granulation tissue were enhanced in α-GalCer administered mice.

  23. Analysis of DAMPs at the wound sites and development of novel wound care on chronic wounds

    Kanno Emi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

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    The role of endogenous damage-related molecular patterns (DAMPs) in skin wound healing remains unclear. In the present study, to identify the possible contribution of CLRs, such as Dectin-2, the expression of Dectin-2 mRNA was examined. Dectin-2 mRNA expression reached peak levels at 12 hours in WT mice, and expression levels declined thereafter to the basal level. we found that both neutrophils and macrophages expressed Dectin-2, and the proportions of these cells expressing Dectin-2 were 40.1±5.0% and 32.1±2.9%, respectively. In immunohistochemical analysis, DAMPs recognized by Dectin-2 was increased in infiltrating cells at the wound site.

  24. Analysis of inframmatory chain mechanism at the wound site through C type lectin receptor (Mincle)

    Kei Yoshikawa, KAWAKAMI Kazuyoshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2016/04/01 - 2018/03/31

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    Macrophage inducible C-type lectin (Mincle) is an activating receptor, expressed in macrophages and dendritic cells, which senses PAMPs and DAMPs. However, the role of Mincle at the wound sites has not been elucidated. In the present study, we addressed a question how defect of Mincle affected to the healing process of wounds. Wounds were created on the backs of wild type (WT) C57BL/6 and Mincle-deficient (KO) mice. We analyzed percent wound closure, height of granulation tissue, expression of Mincle by real-time PCR and immunohistochemistry. The percent wound closure was significantly increased in Mincle KO mice compared to WT mice, which was associated with the increased height of granulation tissues. Mincle was detected at the early phase after wound creation. These results suggest that Mincle may be involved in the regulation of granulation at the wounded tissues, which may lead to delayed wound healing.

  25. Age differences in cardiac autonomic nervous regulation in response in change positions.

    Maruyama Ryoko

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2015/04/01 - 2018/03/31

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    The aim of this study was to evaluate the effect of the spine, left lateral decubitus, and right decubitus position on autonomic nerve activity in young adults and elderly by using spectral analysis of heart rate variability(HRV). After laying in spine position, all participants in a random order and maintained the position for 10 min, while ECG data were recorded to measure HRV. The lowest heart rate continued for 10 min. when participants were in the left decubitus position compared with the other positions, however the HRV remained unchanged. The low frequency to high frequency ratio for the right lateral position was significantly lower than that for the other positions. The right lateral position may attenuate sympathetic nerve activity in elderly adults.

  26. The analysis of lymphocyte function against biofilm formation in chronic wound

    TANNO HIROMASA

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up

    Category: Grant-in-Aid for Research Activity Start-up

    Institution: Tohoku University

    2015/08/28 - 2017/03/31

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    Pseudomonas aeruginosa is frequently isolated from chronic wounds.NKT cells play an important role in various aspects of the regulation immune responses, including protection against bacterial infections. However, it is not fully understood how this lymphocyte is involved in the host defense against P. aeruginosa wound infection. In the present sudy,we elucidated the role of NKT cells in clearance of P. aeruginosa from the wound. NKT cell-deficient mice showed impaired clearance of P. aeruginosa. These results indicate that NKT cells may be involved in the clearance of P. aeruginosa from wounds.

  27. The cardiac autonomic nervous response to elderly adults to position change.

    Maruyama Ryoko, Sasaki Kounosuke, Bao Sarina

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2015/04/01 - 2017/03/31

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    In particular, parasympathetic nerve activity as well as arterial baroreflex sensitivity reduces with aging process. In elderly patients with coronary artery disease, high parasympathetic nerve activity and low sympathetic nerve activity have been observed in right lateral decubitus position compared with supine and left lateral decubitus positions. However, little research has been conducted to determine sex and age differences in autonomic nervous activity in different positions, i.e., supine, left recumbent, and right recumbent positions. The aim of this study was to evaluate the effect of the left and right recumbent positions on heart rate variability in elderly was the lowest among the three positions regardless of sex. In elderly men, the LF/HF ratio in right recumbent position was significantly lower than that in supine position. Right recumbent position may attenuate cardiac sympathetic nerve activity in elderly adult men.

  28. Elucidation of IL-17 function and production in the wound healing and the role in chronic wounds

    TAKEDA ATSUSHI, TAKAGI Naoyuki, TANNO Hiromasa

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2014/04/01 - 2017/03/31

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    Interleukin-17 (IL-17) is a proinflammatory cytokine. The role of this cytokine in the wound healing process is not fully clarified. In this study, IL-17A knockout mice showed promoted wound healing and decreased neutrophil accumulation compared with wild-type mice, and the administration of recombinant IL-17A led to delayed wound closure, accelerated neutrophilic accumulation and improved wound repair with treatment of a neutrophil elastase inhibitor. Neutrophils, macrophages and gamma-delta T cels showed IL-17A expression after wounding in wild-type mice. These results indicated that IL-17A hampared the wound healing process and neutrophilic inflammation caused by IL-17 led to impaired wound healing in skin.

  29. Relation birth weight and adult hypertension on ethnic minorities In China

    Maruyama Ryoko, KANNO Emi, MINAMI Yuko, TANNO Hiromasa, BAO Sarina

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2013/04/01 - 2016/03/31

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    Low birth weight(LBW) conformed as a risk of high blood pressure in later life.However, a number of studies have shown that Mongolian people have higher prevalence of hypertension compared to other ethnic groups. including the Japanese. The purpose of this study was to identify whether there are differences in the relationship of LBW and the risk of hypertension between Japanese and Mongolian.We measured BP and heart rate variability at resting condition and postal change for both Japanese and Mongolian volunteers with LBW and normal birth weight,respectively. We conclude that Mongolian young adults a higher risk of hypertension compared to the Japanese counterpart.

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