Details of the Researcher

PHOTO

Atsuhiro Nagasaki
Section
Tohoku University Hospital
Job title
Assistant Professor
Degree

  • 博士（歯学）（広島大学）

Research History 7

  • 2021/04 - Present
    Division of Molecular and Regenerative Prosthodontics, Tohoku University Hospital　Dental Hospital Fixed Prosthodontics

  • 2021/03 - Present
    Laboratory of Oral Connective Tissue Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Institutes of Health (NIH)　Guest Researcher

  • 2020/05 - 2021/03
    Tohoku University Graduate School of Dentistry　Division of Molecular and Regenerative Prosthodontics　Adjunct lecturer

  • 2017/04 - 2021/03
    Laboratory of Oral Connective Tissue Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Institutes of Health (NIH)　National Institutes of Health (NIH)

  • 2013/04 - 2017/04
    独立行政法人 労働者健康安全機構 中国労災病院　病理診断科　非常勤職員

  • 2013/04 - 2014/03
    Hiroshima University Hospital　Oral clinical examination center　Senior resident

  • 2011/04 - 2013/03
    Kochi Medical School　Department of Oral and Maxillofacial Surgery　Resident

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Education 2

  • Hiroshima University　Graduate School of Biomedical & Health Sciences　Department of Oral and Maxillofacial Pathobiology

    2013/04 - 2017/03

  • Hiroshima University　Faculty of Dentistry　Faculty of Dentistry

    2005/04 - 2011/03

Professional Memberships 11

  • International Association for Dental, Oral, and Craniofacial Research

  • 日本口腔インプラント学会

  • 日本老年歯科医学会

  • 東北臨床細胞学会

  • 宮城県臨床細胞学会

  • 日本補綴歯科学会

  • 日本口腔外科学会

  • 日本病理学会

  • 日本臨床細胞学会

  • 日本臨床口腔病理学会

  • 日本口腔検査学会

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Awards 9

  1. 日本歯科医学会第37回「歯科医学を中心とした総合的な研究を推進する集い(令和3年度)」優秀発表賞

    2022/03　日本歯科医学会

  2. 2019 Young Investigator Award

    2019/06

  3. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) IRP POSTER AWARD, 2019 NIAMS IRP Scientific Retreat

    2019/06　National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

  4. 2019 JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE (JSPS) Research Fellowship for Japanese Biomedical and Behavioral Researchers at NIH

    2019/01　JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE

  5. 27th BEST GENERAL POSTER AWARD

    2016/08　Japanese Society of Oral Pathology

  6. 49th Research Incentive Award

    2016/07　Hiroshima University Dental Society

  7. 岩垂育英会奨学生

    2016/04　岩垂育英会

  8. 6th Hiroshima Conference on Education and Science in Dentistry POSTER AWARD

    2015/10　Hiroshima University

  9. The 14th Biennial Congress of the Asian Academy of Prosthodontics (AAP) IPROSI AWARD

    2024/07　Electrically Charged Tissue-Nonspecific Alkaline Phosphatase Promotes Periodontal Tissue Regeneration for an Optimal Fixed Prosthodontics Treatment

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Papers 24

  1. Inhibition of histone deacetylase 3 in dental mesenchyme regulates the development of tooth root. Peer-reviewed

    Niibe K., Begun DL, Doi-Fujimura K., Nagasaki A., Zars E., Li X., Taylor EL, MacDougall MB, Egusa H., Westendor JJ

    J Bone Miner Res, accepted.　2025

  2. 歯性感染とMAFLDの病態進行 Peer-reviewed

    宮内睦美, 古庄寿子, 長﨑敦洋, 坂本真一

    臨床免疫・アレルギー科　81　(5)　471-477　2024

  3. Porphyromonas gingivalis-odontogenic infection is the potential risk for progression of nonalcoholic steatohepatitis-related neoplastic nodule formation International-journal Peer-reviewed

    Sakamoto S, Nagasaki A, Shrestha M, Shintani T, Watanabe,A, Furusho H, Chayama K, Takata Ti, Miyauch M

    Scientific Reports　13　(1)　9350-9350　2023

    DOI： 10.1038/s41598-023-36553-y 　

    More details Close

    Porphyromonas gingivalis (P.g.), a major periodontal pathogen is a known risk factor for various systemic diseases. However, the relationship between P.g. and nonalcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC) is unclear. Thus, we aimed to elucidate whether P.g.-odontogenic infection promotes NASH-related HCC development/progression and to clarify its mechanism. Using high-fat diet (HFD)-induced NASH mouse model, P.g. was infected odontogenically. After 60 weeks of infection, tumor profiles were examined. Chow diet (CD) groups were also prepared at 60 weeks. Nodule formation was only seen in HFD-mice. P.g.-odontogenic infection significantly increased the mean nodule area (P = 0.0188) and tended to promote histological progression score after 60 weeks (P = 0.0956). Interestingly, P.g. was detected in the liver. HFD-P.g. (+) showed numerous TNF-α positive hepatic crown-like structures and 8-OHdG expression in the non-neoplastic liver. In P.g.-infected hepatocytes, phosphorylation of integrin β1 signaling molecules (FAK/ERK/AKT) was upregulated in vitro. In fact, total AKT in the liver of HFD-P.g. (+) was higher than that of HFD-P.g. (-). P.g.-infected hepatocytes showed increased cell proliferation and migration, and decreased doxorubicin-mediated apoptosis. Integrin β1 knockdown inhibited these phenotypic changes. P.g.-odontogenic infection may promote the progression of neoplastic nodule formation in an HFD-induced NASH mouse model via integrin signaling and TNF-α induced oxidative DNA damage.

  4. The RGD region of bone sialoprotein affects metabolic activity in mice Peer-reviewed

    Nagasaki K, Nagasaki A, Taylor J, Kear B, Ma Y, Somerman M, Gavrilova O

    Frontiers Dental Medicine　2023

  5. 非アルコール性脂肪性肝疾患 と歯周病の関連および同疾患 への歯周病治療効果について ―基礎的・臨床的視点から― Peer-reviewed

    三辺正人, 古庄 寿子, 宮内 睦美, 長﨑敦洋, 鎌田要平, 結束貴臣, 中島淳, 児玉利朗

    糖尿病・内分泌代謝科　2022

  6. The Bone Sialoprotein RGD Domain Modulates and Maintains Periodontal Development. Peer-reviewed

    Nagasaki K, Chavez M, Nagasaki A, Taylor J, Tan M, Ma M, Ralston E, Thew M, Kim DG, Somerman M, Foster B

    Journal of Dental Research　2022

  7. Cell-based double-screening method to identify a reliable can-didate for osteogenesis-targeting compounds. Peer-reviewed

    Fukuyasu S, Kayashima H, Moribayashi A, Matsuoka S, Nagasaki A, Okawa H, Yatani H, Saeki M, Egusa E

    Biomedicines　10　(2)　426-426　2022

    Publisher: MDPI AG

    DOI： 10.3390/biomedicines10020426 　

    eISSN： 2227-9059

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    Small-molecule compounds strongly affecting osteogenesis can form the basis of effective therapeutic strategies in bone regenerative medicine. A cell-based high-throughput screening system might be a powerful tool for identifying osteoblast-targeting candidates; however, this approach is generally limited with using only one molecule as a cell-based sensor that does not always reflect the activation of the osteogenic phenotype. In the present study, we used the MC3T3-E1 cell line stably transfected with the green fluorescent protein (GFP) reporter gene driven by a fragment of type I collagen promoter (Col-1a1GFP-MC3T3-E1) to evaluate a double-screening system to identify osteogenic inducible compounds using a combination of a cell-based reporter assay and detection of alkaline phosphatase (ALP) activity. Col-1a1GFP-MC3T3-E1 cells were cultured in an osteogenic induction medium after library screening of 1280 pharmacologically active compounds (Lopack1280). After 7 days, GFP fluorescence was measured using a microplate reader. After 14 days of osteogenic induction, the cells were stained with ALP. Library screening using the Col-1a1/GFP reporter and ALP staining assay detected three candidates with significant osteogenic induction ability. Furthermore, leflunomide, one of the three detected candidates, significantly promoted new bone formation in vivo. Therefore, this double-screening method could identify candidates for osteogenesis-targeting compounds more reliably than conventional methods.

  8. Cyclic pressure-induced cytokines from gingival fibroblasts stimulate osteoclast activity: Clinical implications for alveolar bone loss in denture wearers. Peer-reviewed

    Yoshihiro Akashi, Atsuhiro Nagasaki, Hiroko Okawa, Takuya Matsumoto, Takeru Kondo, Hirofumi Yatani, Ichiro Nishimura, Hiroshi Egusa

    J Prosthodont Res　2022

    DOI： 10.2186/jpr.JPR_D_21_00238 　

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    PURPOSE: The involvement of oral mucosa cells in mechanical stress-induced bone resorption is unclear. The aim of this study was to investigate the effects of cyclic pressure-induced cytokines from oral mucosal cells (human gingival fibroblasts: hGFs) on osteoclast activity in vitro. METHODS: Cyclic pressure at 50 kPa, which represents high physiologic occlusal force of dentures on the molar area, was applied to hGFs. NFAT-reporter stable RAW264.7 preosteoclasts (NFAT/Luc-RAW cells) were cultured in conditioned medium collected from hGF cultures under cyclic pressure or static conditions. NFAT activity and osteoclast formation were determined by luciferase reporter assay and TRAP staining, respectively. Cyclic pressure-induced cytokines in hGF culture were detected by ELISA, real-time RT-PCR, and cytokine array analyses. RESULTS: Conditioned media from hGFs treated with 48 hours of cyclic pressure significantly induced NFAT activity and increased multinucleated osteoclast formation. Furthermore, the cyclic pressure significantly increased the bone resorption activity of RAW264.7 cells. Cyclic pressure significantly increased the expression of major inflammatory cytokines including IL-1β/IL-1β, IL-6/IL-6, IL-8/IL-8 and MCP-1/CCL2 in hGFs compared to hGFs cultured under static conditions, and it suppressed osteoprotegerin (OPG/OPG) expression. A cytokine array detected 12 cyclic pressure-induced candidates. Among them, IL-8, decorin, MCP-1 and ferritin increased, whereas IL-28A and PDGF-BB decreased, NFAT activation of NFAT/Luc-RAW cells. CONCLUSION: These results suggest that cyclic pressure-induced cytokines from hGFs promote osteoclastogenesis, possibly including up-regulation of IL-1β, IL-6, IL-8 and MCP-1, and down-regulation of OPG. These findings introduce the possible involvement of GFs in mechanical stress-induced alveolar ridge resorption, such as in denture wearers.

  9. Elimination of Porphyromonas gingivalis inhibits liver fibrosis and inflammation in NASH Peer-reviewed

    Atsuhiro Nagasaki, Shinnichi Sakamoto, Toshiki Arai, Minami Kato, Eri Ishida, Hisako Furusho, Makiko Fujii, Takashi Takata, Mutsumi Miyauchi

    Journal of Clinical Periodontology　48　(10)　1367-1378　2021/10

    Publisher: Wiley

    DOI： 10.1111/jcpe.13523 　

    ISSN： 0303-6979

    eISSN： 1600-051X

  10. Delivery of Alkaline Phosphatase Promotes Periodontal Regeneration in Mice Peer-reviewed

    A. Nagasaki, K. Nagasaki, B.D. Kear, W.D. Tadesse, J.L. Millan, Thumbigere-Math. Math, B.L. Foster, M.J. Somerman

    Journal of Dental Research　2021/08

  11. Ablation of Pyrophosphate Regulators Promotes Periodontal Regeneration Peer-reviewed

    A. Nagasaki, K. Nagasaki, E.Y. Chu, B.D. Kear, W.D. Tadesse, S.E. Ferebee, L. Li, B.L. Foster, M.J. Somerman

    Journal of Dental Research　002203452098185-002203452098185　2020/12/24

    Publisher: SAGE Publications

    DOI： 10.1177/0022034520981854 　

    ISSN： 0022-0345

    eISSN： 1544-0591

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    Biomineralization is regulated by inorganic pyrophosphate (PPi), a potent physiological inhibitor of hydroxyapatite crystal growth. Progressive ankylosis protein (ANK) and ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) act to increase local extracellular levels of PPi, inhibiting mineralization. The periodontal complex includes 2 mineralized tissues, cementum and alveolar bone (AB), both essential for tooth attachment. Previous studies demonstrated that loss of function of ANK or ENPP1 (reducing PPi) resulted in increased cementum formation, suggesting PPi metabolism may be a target for periodontal regenerative therapies. To compare the effects of genetic ablation of Ank, Enpp1, and both factors concurrently on cementum and AB regeneration, mandibular fenestration defects were created in Ank knockout ( Ank KO), Enpp1 mutant ( Enpp1asj/asj), and double KO (dKO) mice. Genetic ablation of Ank, Enpp1, or both factors increased cementum regeneration compared to controls at postoperative days (PODs) 15 and 30 ( Ank KO: 8-fold, 3-fold; Enpp1asj/asj: 7-fold, 3-fold; dKO: 11-fold, 4-fold, respectively) associated with increased fluorochrome labeling and expression of mineralized tissue markers, dentin matrix protein 1 ( Dmp1/DMP1), osteopontin ( Spp1/OPN), and bone sialoprotein ( Ibsp/BSP). Furthermore, dKO mice featured increased cementum thickness compared to single KOs at POD15 and Ank KO at POD30. No differences were noted in AB volume between genotypes, but osteoblast/osteocyte markers were increased in all KOs, partially mineralized osteoid volume was increased in dKO versus controls at POD15 (3-fold), and mineral density was decreased in Enpp1asj/asj and dKOs at POD30 (6% and 9%, respectively). Increased numbers of osteoclasts were present in regenerated AB of all KOs versus controls. These preclinical studies suggest PPi modulation as a potential and novel approach for cementum regeneration, particularly targeting ENPP1 and/or ANK. Differences in cementum and AB regeneration in response to reduced PPi conditions highlight the need to consider tissue-specific responses in strategies targeting regeneration of the entire periodontal complex.

  12. Genetic and pharmacologic modulation of cementogenesis via pyrophosphate regulators Peer-reviewed

    E.Y. Chu, T.D. Vo, M.B. Chavez, A. Nagasaki, E.L. Mertz, F.H. Nociti, S.F. Aitken, D. Kavanagh, K. Zimmerman, X. Li, P.R. Stabach, D.T. Braddock, J.L. Millán, B.L. Foster, M.J. Somerman

    Bone　136　115329-115329　2020/07

    Publisher: Elsevier BV

    DOI： 10.1016/j.bone.2020.115329 　

    ISSN： 8756-3282

  13. Odontogenic infection by Porphyromonas gingivalis exacerbates fibrosis in NASH via hepatic stellate cell activation Peer-reviewed

    Atsuhiro Nagasaki, Shinnichi Sakamoto, Chanbora Chea, Eri Ishida, Hisako Furusho, Makiko Fujii, Takashi Takata, Mutsumi Miyauchi

    Scientific Reports　10　(1)　2020/03

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-020-60904-8 　

    eISSN： 2045-2322

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    Abstract Odontogenic infection of Porphyromonas gingivalis (P.g.), a major periodontal pathogen, exacerbates pathological progression of non-alcoholic steatohepatitis (NASH). In this study, we aimed to clarify the detailed mechanism in which P.g. induced hepatic stellate cells (HSCs; key effector cells in liver fibrosis) activation. In the liver of high fat diet-induced NASH mouse model with P.g. odontogenic infection, immunolocalization of P.g. was detected. The number of hepatic crown-like structure, which was macrophage aggregation and related to liver fibrosis, was drastically increased and fibrosis area was also increased through upregulating immunoexpression of Phosphorylated Smad2 (key signaling molecule of TGF-β1) and Galectin-3. P.g.-secreted trypsin-like enzyme [gingipain; an activator of protease-activated receptor 2 (PAR2)] stimulated HSC proliferation and differentiation through Smad and ERK signaling induced by TGF-β1 produced from HSCs with P.g.-infection. Further, Galectin-3 produced from HSCs with P.g. infection and P.g.-derived LPS/lipoprotein stimulation stabilized TGFβ-receptor II resulting in increasing sensitivity for TGF-β1, finally leading to HSC differentiation via activating Smad and ERK signaling. In addition to them, hepatocytes (main component cells of liver) contributed to HSC activation through TGF-β1 and Galectin-3 production in paracrine manner. Collectively, P.g.-odontogenic infection exacerbates fibrosis of NASH by HSC activation through TGF-β1 and Gal-3 production from HSCs and hepatocytes.

  14. Galectin-3 Plays an Important Role in Preterm Birth Caused by Dental Infection of Porphyromonas gingivalis. Peer-reviewed

    Miyauchi M, Ao M, Furusho H, Chea C, Nagasaki A, Sakamoto S, Ando T, Inubushi T, Kozai K, Takata T

    Scientific Reports　8　(1)　2018

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-018-21072-y 　

    eISSN： 2045-2322

  15. Central mucoepidermoid carcinoma arising from glandular odontogenic cyst confirmed by analysis of MAML2 rearrangement: A case report Peer-reviewed

    Atsuhiro Nagasaki, Ikuko Ogawa, Yukiko Sato, Kengo Takeuchi, Masae Kitagawa, Toshinori Ando, Shinnichi Sakamoto, Madhu Shrestha, Kaori Uchisako, Koichi Koizumi, Shigeaki Toratani, Masaru Konishi, Takashi Takata

    Pathology International　68　(1)　31-35　2018/01/01

    Publisher: Blackwell Publishing

    DOI： 10.1111/pin.12609 　

    ISSN： 1440-1827 1320-5463

  16. Osteodystrophy in cholestatic liver diseases is attenuated by anti-γ-glutamyl transpeptidase antibody Peer-reviewed

    Yusuke Kawazoe, Mutsumi Miyauchi, Atsuhiro Nagasaki, Hisako Furusho, Syunryo Yanagisawa, Chea Chanbora, Toshihiro Inubushi, Hideyuki Hyogo, Takashi Nakamoto, Keiko Suzuki, Sawako Moriwaki, Susumu Tazuma, Shumpei Niida, Takashi Takata

    PLoS ONE　10　(9)　2015/09/29

    Publisher: Public Library of Science

    DOI： 10.1371/journal.pone.0139620 　

    ISSN： 1932-6203

  17. Dental infection of Porphyromonas gingivalis induces preterm birth in mice Peer-reviewed

    Min Ao, Mutsumi Miyauchi, Hisako Furusho, Toshihiro Inubushi, Masae Kitagawa, Atsuhiro Nagasaki, Shinichi Sakamoto, Katsuyuki Kozai, Takashi Takata

    PLoS ONE　10　(8)　2015/08/31

    Publisher: Public Library of Science

    DOI： 10.1371/journal.pone.0137249 　

    ISSN： 1932-6203

  18. CRTC1-MAML2融合遺伝子を検出した嚢胞状粘表皮癌の1例. Peer-reviewed

    大林真理子, 長﨑敦洋, 水田邦子, 小川郁子, 髙田 隆

    診断病理　2015

  19. インプラント術前検査としてのチタンアレルギー検査の意義. Peer-reviewed

    北川雅恵, 大林真理子, 長﨑敦洋, 柳沢俊良, 新谷智章, 香川和子, 安部倉 仁, 日浅 恭, 久保隆靖, 武知正晃, 小川郁子, 栗原英見

    日本口腔検査学会雑誌　7　(1)　31-34　2015

    Publisher: 日本口腔検査学会

    DOI： 10.15041/3660 　

    ISSN： 1883-3888

  20. 歯科用金属中のパラジウムによるアレルギーの関与が疑わ れた口腔扁平苔癬の１症例. Peer-reviewed

    北川雅恵, 近江史恵, 岡本佳明, 長﨑敦洋, 大林真理子, 新谷智章, 虎谷茂昭, 小川郁子, 栗原英見

    日本口腔検査学会雑誌　6　(1)　66-70　2014

    Publisher: 日本口腔検査学会

    ISSN： 1883-3888

  21. Infection with Porphyromonas gingivalis Exacerbates Endothelial Injury in Obese Mice. Peer-reviewed

    Ao M, Miyauchi M, Inubushi T, Kitagawa M, Furusho H, Ando T, Ayuningtyas NF, Nagasaki A, Ishihara K, Tahara H, Kozai K, Takata T

    PLoSOne　2014

  22. 特発性唾液腺型高アミラーゼ血症の1例 Peer-reviewed

    長﨑敦洋, 仙頭慎哉, 笹部衣里, 北村直也, 山田朋弘, 山本哲也

    日本口腔外科学会雑誌　2013

  23. A case of unilateral and isolated idiopathic hypoglossal nerve palsy Peer-reviewed

    59　(6)　427-431　2013

    Publisher:

    ISSN： 0021-5163

  24. Synthetic ameloblastin peptide stimulates differentiation of human periodontal ligament cells Peer-reviewed

    Masae Kitagawa, Shoji Kitagawa, Atsuhiro Nagasaki, Mutsumi Miyauchi, Takashi Uchida, Takashi Takata

    Archives of Oral Biology　56　(4)　374-379　2011/04

    DOI： 10.1016/j.archoralbio.2010.10.012 　

    ISSN： 0003-9969

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Misc. 4

  1. 粘表皮癌の確定診断における融合遺伝子検索の有用性

    長崎敦洋, 小川郁子, 大内知之, 長尾俊孝, 髙田 隆

    日本唾液腺学会誌　56　33-33　2015/11

  2. DENTAL INFECTION OF PORPHYROMONAS GINGIVALIS INDUCES PRETERM BIRTH

    Mutsumi Miyauchi, Hisako Furusho, Atsuhiro Nagasaki, Satoshi Urabe, Haruhisa Konishi, Hiroshi Miyoshi, Yoshiki Kudo, Takashi Takata

    PLACENTA　35　(10)　A22-A22　2014/10

    ISSN： 0143-4004

    eISSN： 1532-3102

  3. CRTC1-MAML2融合遺伝子産物の同定により診断を確定した顎骨中心性粘表皮癌の1例

    小川 郁子, 鈴木 理樹, 柳沢 俊良, 長崎 敦洋, 大久保 康彦, 坂本 洋右, 太田 聡, 中谷 行雄, 長尾 俊孝, 高田 隆

    日本病理学会会誌　103　(1)　297-297　2014/03

    Publisher: (一社)日本病理学会

    ISSN： 0300-9181

  4. 上顎歯肉腫瘍(Spindle cell carcinoma)

    長崎 敦洋, 大林 真理子, 高田 隆, 島末 洋, 中元 崇, 小川 郁子, 有廣 光司

    広島医学　66　(11)　661-661　2013/11

    Publisher: 広島医学会

    ISSN： 0367-5904

Presentations 78

  1. Progressive ankylosis protein regulates macrophage immunological responses in bone healing

    Atsuhiro Nagasaki, Keita Saeki, Karin Nagasaki, Muhammad Dimas Aditya Ari, Keiko Ozato, Martha Somerman, Hiroshi Egusa

    2025/06/27

  2. Bone sialoprotein modulates immunological responses of macrophages in bone healing

    Atsuhiro Nagasaki, Keita Saeki, Karin Nagasaki, Muhammad Dimas Aditya Ari, Keiko Ozato, Martha Somerman, Hiroshi Egusa

    The 54th Annual Meeting & Exhibition of the American Association for Dental, Oral, and Craniofacial Research (AADOCR) and the 49th Annual Meeting of the Canadian Association for Dental Research　2025/03/13

  3. Development of new therapy for periodontal tissue regeneration using electric charge mechanism of recombinant protein

    2025/03/03

  4. 帯電効果を付与した組織非特異的アルカリフォスファターゼを用いた新規歯周組織再生療法の開発

    長﨑敦洋, Muhammad Dimas, Aditya Ari, 山田将博, 八井田朱音, 沖野晃俊, 江草 宏

    東北大学大学院歯学研究科-東京科学大学未来研 研究連携事業（IDEA）　2024/12/20

  5. Tissue-Nonspecific Alkaline Phosphatase Tagged with Aspartic Acid Residues Promotes Periodontal Tissue Regeneration

    Muhammad Dimas Aditya Ari, Atsuhiro Nagasaki, Masahiro Yamada, Akane Yaida, Akitoshi Okino, Hiroshi Egusa

    The 9th International Symposium on Biomedical Engineering　2024/12/03

  6. 口腔機能と全身疾患との関連性に関する探索的研究の紹介

    長﨑敦洋, 菅野響子, 江草 宏

    東北大学COI-NEXT合同シンポジウム2024　2024/10/10

  7. 口腔機能と緑内障との関連性に関する探索的研究

    菅野響子, 長﨑敦洋, 江草 宏

    令和6年度 公益社団法人 日本補綴歯科学会 東北・北海道支部学術大会　2024/10/06

  8. Electrically Charged Tissue-Nonspecific Alkaline Phosphatase Promotes Periodontal Tissue Regeneration for an Optimal Fixed Prosthodontics Treatment

    Muhammad Dimas Aditya Ari, Atsuhiro Nagasaki, Hiroshi Egusa

    The 14th Biennial Congress of the Asian Academy of Prosthodontics IPROSI　2024/07/06

  9. Functional role of bone sialoprotein in implant osseointegration

    2024/07/06

  10. 口腔機能と全身疾患の関連に関する疫学研究の紹介 Invited

    長﨑敦洋, 菅野響子, 江草 宏

    第5回 若手研究者のためのネットワーキング（医学部研究力強化ワーキンググループ）　2024/07/04

  11. 骨シアロタンパク質の骨免疫機構に着目した新規硬組織再生療法の開発

    長﨑敦洋

    第2回器官再生・幹細胞研究会　2024/05/25

  12. 口腔機能と全身状態との関連を探る

    菅野響子, 長﨑敦洋, 江草 宏

    東北大学COI-NEXT「Vision to Connect」拠点会議　2024/04/26

  13. A Novel Therapy for Mineralized Tissue Regeneration Using Tissue-Nonspecific Alkaline Phosphatase Utilizing an Electric Charge Mechanism

    2024/03/08

  14. 全身疾患・全身状態と口腔機能の関連に関する疫学研究

    菅野響子, 長﨑敦洋, 江草 宏

    東北大学COI-NEXT「Vision to Connect」拠点シンポジウム　2023/08/29

  15. 骨・セメント質再生におけるリン酸/ピロリン酸代謝の役割と再生療法への応用

    長﨑敦洋, 江草 宏

    日本補綴歯科学会 Prosthodontic Meeting for Next Generation 2023　2023/03/10

  16. Development new therapy for periodontal tissue regeneration using electric charge mechanism

    TI-FRIS/FRIS Symposium 2023　2023/02/14

  17. 酵素タンパク質の荷電制御に基づく硬組織再⽣の新機軸

    長﨑敦洋, 鹿内陽樹, 楠山譲二, 江草 宏

    2nd TI-FRIS Symposium / FRIS Annual Meeting 2022　2022/03/01

  18. アルカリフォスファターゼの硬組織結合制御による新規歯周組織再生療法の開発

    長﨑敦洋, 江草 宏

    日本歯科医学会 第37回「歯科医学を中心とした総合的な研究を推進する集い」　2022/02/15

  19. Alkaline Phosphatase, a Targeted Mineral Enzyme Therapy, Promotes Periodontal Tissue Regeneration

    Brock S, Nagasaki A, Somerman M

    Postbaccalaureate Poster Day 2021, National Institutes of Health　2021/04/29

  20. Pyrophosphate regulators modulate periodontal regeneration Invited

    Nagasaki A

    Matrix Biology SIG Meeting　2021/01/13

  21. Local delivery of alkaline phosphatase promotes cementum/alveolar bone regeneration.

    Nagasaki A, Nagasaki K, Kear B, Tadesse W, Ferebee S, Thumbigere-Math V, Millán JL, Foster B, Somerman M

    2020 National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Annual Scientific Retreat　2020

  22. An Aattractive Candidate for Regeneration of Periodontal Tissue.

    Kear B, Nagasaki A, Somerman M

    NIH VIRTUAL POSTBAC POSTER DAY　2020

  23. The BSP RGD domain regulates periodontal ligament formation during development.

    Nagasaki K, Ma M, Chavez M, Ao M, Chu E, Nagasaki A, Ferebee S, Kear B, Foster B, Somerman M

    2020 International Association for Dental Research　2020

  24. Delivery of alkaline phosphatase promotes cementum and alveolar bone regeneration.

    Nagasaki A, Tadesse W, Nagasaki K, Ma M, Ferebee S, Kear B, Thumbigere-Math V, Millán JL, Foster B, Somerman M

    2020 International Association for Dental Research　2020

  25. Role of ANK and ENPP1 during cementum and alveolar bone regeneration.

    Nagasaki A, Tadesse W, Chu E, Nagasaki K, Ferebee S, Kear B, Nociti FH, Foster B, Somerman M

    The 4th Japan-US Science Forum in Boston　2019

  26. ANK and ENPP1 modulate cementum and alveolar bone regeneration.

    Nagasaki A, Tadesse W, Chu E, Nagasaki K, Ferebee S, Kear B, Nociti FH, Foster B, Somerman M

    NIH-Japan-JSPS (Japan Society for the Promotion of Science) symposium　2019

  27. Cementum regeneration is augmented with loss of ANK and ENPP1.

    Nagasaki A, Tadesse W, Chu E, Nagasaki K, Nociti FH, Chavez M, Foster B, Somerman M

    2019 International Association for Dental Researc　2019

  28. Bone sialoprotein modulates the periodontal complex in conjunction with osteopontin.

    Nagasaki K, Chavez M, Chu E, Ma M, Alexander R, Nagasaki A, Vo T, Tadesse W, Foster B, Somerman M

    2019 International Association for Dental Research　2019

  29. Bone sialoprotein modulates the periodontal complex in conjunction with osteopontin.

    Nagasaki K, Chavez M, Chu E, Ma M, Alexander R, Nagasaki A, Vo T, Tadesse W, Foster B, Somerman M

    2019 National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Scientific Retreat　2019

  30. Cementum regeneration is augmented with loss of ANK and ENPP1.

    Nagasaki A, Tadesse W, Chu E, Nagasaki K, Nociti FH, Chavez M, Foster B, Somerman M

    2019

  31. Loss of ANK and ENPP1, Regulators of PPi/Pi, Promote Cementogenesis.

    Tadesse W, Nagasaki A, Somerman M

    NIH POSTBAC POSTER DAY　2019

  32. ANK and ENPP1 have potential effects on cementogenesis through regulation of SIBLINGs.

    Nagasaki A, Emily C, Leigh D, Vo T, Chavez M, Foster B, Somerman M

    2018

  33. ANK and ENPP1 Have Significant Roles in Cementogenesis.

    Nagasaki A, Chu E, Leigh D, Vo T, Chavez M, Foster B, Somerman M

    The 47th Annual Meeting & Exhibition of the American Association for Dental Research and 42nd Annual Meeting of the Canadian Association for Dental Research　2018

  34. Porphyromonas gingivalis 歯性感染は肝星細胞を活性化し、非アルコール性脂肪性肝炎の病態を増悪する.

    宮内睦美, 長﨑敦洋, 坂本真一, 古庄寿子, 髙田 隆

    第 60 回 春季日本歯周病学会学術大会　2017

  35. Porphyromonas gingivalis 歯性感染は肝星細胞を活性化し, 非アルコール性脂肪性肝炎の病態を増悪する.

    長﨑敦洋, 坂本真一, 古庄寿子, 宮内睦美, 髙田 隆

    岩垂育英会奨学生研究成果発表会　2017

  36. Elimination of Porphyromonas gingivalis-infection by dental treatments is a beneficial impact on non-alcoholic steatohepatitis.

    2016

  37. 下唇に発生した小唾液腺導管内唾石症の1例.

    中川貴之, 島末 洋, 小野重弘, 加藤大喜, 長﨑敦洋, 宮内睦美, 武知正晃

    第61回日本口腔外科学会総会・学術大会　2016

  38. Galectin-3抑制はPorphyrompnas gingivalis の歯性感染症による早産を予防する.

    石田えり, 長尾日香里, 趙 継美, 仏師田丈, 坂本真一, 長﨑敦洋, 古庄寿子, 宮内睦美, 髙田 隆

    第23回日本歯科医学会総会　2016

  39. Porphyrompnas gingivalis の歯性感染症は肝星細胞を活性化し、非アルコール性脂肪性肝炎の病態を進行させる.

    加藤みなみ, 長﨑敦洋, 宮内睦美, 髙田 隆

    平成28年度 第22回日本歯科医師会/デンツプライ SCRP日本代表選抜大会　2016

  40. Odontogenic infection of Porphyromonas gingivalis exacerbates pathological progression of non-alcoholic steatohepatitis through activation of hepatic stellate cells.

    2016

  41. 腺性歯原性嚢胞から悪性化したと考えられる粘表皮癌の１例.

    内迫香織, 小泉浩一, 檜垣美雷, 石田康隆, 虎谷茂昭, 長﨑敦洋, 安藤俊範, 小川郁子, 岡本哲治

    第45回日本口腔外科学会中国四国支部学術集会　2016

  42. 口蓋腫瘍 (Mucoepidermoid carcinoma, clear cell variant).

    小川郁子, 安藤俊範, 長﨑敦洋, 岡本康正, 谷 亮治, 小西 勝, 髙田 隆

    第119回日本病理学会中国四国支部学術集会 (スライドカンファレンス)　2016

  43. Key roles of TLR2 in NASH progression by P.g.-odontogenic infection.

    Furusho H, Nagasaki A, Sakamoto S, Miyauchi M, Takata T

    The 94th General Session & Exhibition of the International Association for Dental Research, 64th Annual Meeting of Japanese Association of Dental Research　2016

  44. 粘表皮癌の確定診断における融合遺伝子検索の有用性.

    長﨑敦洋, 小川郁子, 大内知之, 長尾俊孝, 髙田 隆

    第60回日本唾液腺学会学術大会　2015

  45. 歯科的治療介入はPorphyromonas gingivalis歯性感染に伴う非アルコール性脂肪性肝炎の病態進行を抑制する.

    長﨑敦洋, 坂本真一, 古庄寿子, 宮内睦美, 髙田 隆

    第54回広島県歯科医学会・第99回広島大学歯学会・日本歯科技工学会中国・四国支部第10回学術大会　2015

  46. Porphyromonas gingivalis 歯性感染はマクロファージを介して肝星細胞を活性化し非アルコール性脂肪性肝炎の病態を進行させる.

    長﨑敦洋, 古庄寿子, 宮内睦美, 髙田 隆

    第57回歯科基礎医学会学術大会　2015

  47. 口腔底腫瘍 (Squamous cell carcinoma, poorly differentiated, clear cell dominant).

    古庄寿子, 長﨑敦洋, 宮内睦美, 小川郁子, 谷 亮治, 末井良和, 髙田 隆

    第 64 回広島病理集談会　2015

  48. TLR2 plays a key role in P. gingivalis-induced NASH progression.

    Furusho H, Miyauchi M, Nagasaki A, Sakamoto S, Takata T

    2015

  49. 歯周病は肝臓の病気に悪影響を及ぼす-歯周病原細菌の検査と歯科治療の重要性について-.

    宮内睦美, 古庄寿子, 長﨑敦洋, 新谷智章, 栗原英見, 茶山一彰, 髙田 隆

    第8回日本口腔検査学会総会・学術大会　2015

  50. 歯科用金属アレルギーと皮膚・粘膜疾患との関連性の検討.

    北川雅恵, 長﨑敦洋, 辻 浩紀, 新谷智章, 小川郁子, 栗原英見, 柴 秀樹

    第8回日本口腔検査学会総会・学術大会　2015

  51. Dental infection of Porphyromonas gingivalis exacerbates pathological progression of non-alcoholic steatohepatitis (NASH)

    Miyauchi M, Furusho H, Nagasaki A, Sakamoto S, Ouhara K, Kurihara H, Takata T

    The 6th Hiroshima Conference on Education and Science in Dentistry　2015

  52. TLR2 plays a key role in P.gingivalis-induced NASH progression.

    Furusho H, Miyauchi M, Nagasaki A, Sakamoto S, Takata T

    6th Hiroshima Conference on Education and Science in Dentistry　2015

  53. Odontogenic infection of Porphyromonas gingivalis exacerbates pathological progression of non-alcoholic steatohepatitis through activation of hepatic stellate cell.s by macrophages

    Nagasaki A, Sakamoto S, Furusho H, Miyauchi M, Takata T

    The 6th Hiroshima Conference on Education and Science in Dentistry　2015

  54. Dental infection of Porphyromonas gingivalis (P.g.) exacerbates progression of non-alcoholic steatohepatitis –Effects of P.g. infection and P.g.-LPS on Hepatocytes

    Miyauchi M, Furusho H, Nagasaki A, Takata T

    The 93rd General Session & Exhibition of the International Association for Dental Research　2015

  55. The effects of Porphyromonas gingivalis infection on hepatocytes.

    Sakamoto S, Furusho H, Nagasaki A, Miyauchi M, Hisatsune J, Sugai M, Tahara H, Takata T

    2014

  56. 耳下腺腫瘍 (Mammary analogue secretory carcinoma of salivary gland).

    安藤俊範, 長﨑敦洋, 西 阪 隆, 小川郁子, 髙田 隆

    第 63 回広島病理集談会　2014

  57. 17th International congress on Oral Pathology and Medicine

    長﨑敦洋

    平成26年度第2回医歯薬保健学研究院・研究科 FD　2014

  58. S2529 乳腺腫瘍の1例 (Adenoid cystic carcinoma).

    長﨑敦洋, 小川郁子, 髙田 隆, 西田俊博

    第115回日本病理学会中国四国支部学術集会 (スライドカンファレンス)　2014

  59. Porphyromonas gingivalis 歯性感染は早産を誘導する.

    宮内睦美, 古庄寿子, 長﨑敦洋, 占部 智, 小西晴久, 三好博史, 工藤美樹, 髙田 隆

    第 22 回日本胎盤学会学術集会　2014

  60. インプラント術前検査としてのチタンアレルギー検査の意義.

    北川雅恵, 大林真理子, 長﨑敦洋, 柳沢俊良, 新谷智章, 香川和子, 安部倉 仁, 日浅 恭, 久保隆靖, 武知正晃, 小 川郁子, 栗原英見

    第 7 回日本口腔検査学会総会・学術大会　2014

  61. 歯周病原細菌 Porphyromonas gingivalis の歯性感染は NASH の病態を増悪する.

    宮内睦美, 古庄寿子, 長﨑敦洋, 髙田 隆

    Clinical Lipid Seminar 2014　2014

  62. Porphyromonas gingivalis 歯性感染は早期低体重児出産を誘導する.

    宮内睦美, 古庄寿子, 長﨑敦洋, 髙田 隆

    第 103 回日本病理学会総会　2014

  63. CRTC1-MAML2 融合遺伝子産物の同定により診断を確定した顎骨中心性粘表皮癌の 1 例.

    小川郁子, 鈴木理樹, 柳沢俊良, 長﨑敦洋, 大久保康彦, 坂本洋右, 太田 聡, 中谷行雄, 長尾俊孝, 髙田 隆

    第 103 回日本病理学会総会　2014

  64. S2519 膵腫瘍の1例 (Solid-pseudopapillary neoplasm).

    長﨑敦洋, 小川郁子, 髙田 隆, 西田俊博

    第114回日本病理学会中国四国支部学術集会 (スライドカンファレンス)　2014

  65. 口蓋腫瘍 (Mucoepidermoid carcinoma).

    大林真理子, 長﨑敦洋, 水田邦子, 小川郁子, 髙田 隆

    第114回日本病理学会中国四国支部学術集会 (スライドカンファレンス)　2014

  66. 非アルコール性脂肪性肝炎の病態進行におよぼす歯周病の影響に関する実態調査.

    宮内 睦美, 古庄寿子, 長﨑敦洋, 髙田 隆

    第30回歯科医学を中心とした総合的な集い　2014

  67. Significance of fusion gene analysis for the differential diagnosis of mucoepidermoid carcinoma.

    Nagasaki A, Ando T, Obayashi M, Ogawa I, Takata T

    2014

  68. シェーグレン症候群とIgG4関連疾患の診断における口唇生検の役割.

    長﨑敦洋, 北川雅恵, 新谷智章, 小川郁子, 栗原英見, 髙田 隆

    第58回日本唾液腺学会学術大会　2013

  69. S2485 乳腺腫瘍の1例 (Myoepithelial carcinoma).

    長﨑敦洋, 小川郁子, 髙田 隆, 西田俊博

    第112回日本病理学会中国四国支部学術集会 (スライドカンファレンス)　2013

  70. シェーグレン症候群, IgG4関連疾患の診断における口唇生検の意義.

    長﨑敦洋, 北川雅恵, 新谷智章, 小川郁子, 栗原英見

    第6回口腔検査学会　2013

  71. S752 上顎歯肉腫瘍の1例 (Spindle cell carcinoma).

    長﨑敦洋, 大林真理子, 島末 洋, 中元 崇, 小川郁子, 有廣光司, 髙田 隆

    第60回広島病理集談会　2013

  72. Hyperamylasemia without pancreatic and salivary diseases.

    Nagasaki A, Sasabe E, Yamada T, Yamamoto T

    2012/04/27

  73. 原因不明の唾液腺型高アミラーゼ血症の1例.

    長﨑敦洋, 仙頭慎哉, 笹部衣里, 山田朋弘, 山本哲也

    第57回日本口腔外科学会総会 学術大会　2012

  74. 口腔外科手術後感染に対する臨床細菌学的検討.

    長﨑敦洋, 李 康広, 笹部衣里, 山田朋弘, 山本哲也

    第8回高知県口腔科学会　2012

  75. Hyperamylasemia without pancreatic and salivary diseases.

    Nagasaki A, Sasabe E, Yamada T, Yamamoto T

    Research council of Sino-Japan Universities (Kochi Medical School, Shanghai Jiao Tong University School of Medicine, Capital Medical University)　2012

  76. HIV陽性Castleman病患者に発生した口腔内カポジ肉腫の1例.

    長﨑敦洋, 李 康広, 笹部衣里, 山田朋弘, 山本哲也

    第59回日本口腔科学会中国四国地方部会　2011

  77. ヘパリンおよびその誘導体を用いた骨組織再生に関する研究 -2DSH-collagen sponge disk による検討

    北川雅恵, 長﨑敦洋, 宮内睦美, 高田 隆

    「QOL を考える歯学連携ネットワ ークを活用した口腔から QOL 向上を目指す研究」再生工学カテゴリー第2回学内研究集会　2010

  78. 高γ-グルタミルトランスぺプチダーゼ血症は骨粗鬆症を誘導する.

    山口聡, 長﨑敦洋, 犬伏俊博, 宮内睦美, 髙田隆

    第 92 回広島大学歯学会　2010

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Industrial Property Rights 1

  1. TNAP Locally Administered for Promoting Periodontal Health.

    Atsuhiro Nagasaki, Martha J. Somerman, Nadine L. Samara, Brian L. Foster, Jose Luis Millan

    Property Type: Patent

Research Projects 8

  1. 硬組織結合型合成タンパク質による新規硬組織再生療法の事業化

    System: JST大学発新産業創出基金事業 スタートアップ・エコシステム共創プログラム／拠点都市プラットフォーム共創支援

    2025/04 - 2026/04

  2. 帯電効果を利用した硬組織結合型合成タンパク質による骨再生療法の開発

    System: 2025年度生体医歯工学共同研究拠点共同研究

    2025/04 - 2026/03

  3. 骨シアロタンパク質の骨免疫機構に着目した骨再生・インプラント骨結合促進技術の開発

    2024/04 - 2026/03

  4. 硬組織結合型アルカリフォスファターゼによる新規硬組織再生療法の 開発・事業化

    System: 東北大学スタートアップ創出支援ビジネスインキュベーションプログラム（BIP）

    2024/08 - 2025/03

  5. 2024年度生体医歯工学共同研究拠点共同研究

    2024/04 - 2025/02

  6. ⼝腔機能検査に基づいた⾷品加⼯技術の開発

    Offer Organization: 革新的食学拠点コンソーシアム

    System: 令和５年度⾷学拠点研究スタートアップ⽀援制度

    2023/12 - 2024/03

  7. 帯電による結合作用を利用した新規石灰化促進タンパク質製剤の開発

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 若手研究

    2021/04 - 2024/03

  8. 酵素タンパク質の荷電制御に基づく硬組織再生の新機軸

    Offer Organization: 東北大学 学際科学フロンティア研究所

    System: 領域創成研究プログラム

    2021/06 - 2023/03

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