Details of the Researcher

PHOTO

Masahiro Okada
Section
Graduate School of Dentistry
Job title
Associate Professor
Degree

  • Ph.D. (Kobe University)

e-Rad No.
70416220

Research History 9

  • 2024/04 - Present
    Tohoku University　Associate Professor

  • 2021/04 - 2024/03
    Okayama University　Graduate School of Medicine, Dentistry and Pharmaceutical Sciences　Associate Professor

  • 2014/04 - 2023/03
    大阪歯科衛生士専門学校　非常勤講師

  • 2014/06 - 2021/03
    Okayama University　Graduate School of Medicine , Dentistry and Pharmaceutical Sciences　Associate Professor

  • 2010/10 - 2014/05
    Osaka Dental University　Department of Biomaterials　Assistant Professor

  • 2010/04 - 2010/09
    Kindai University　Faculty of Biology-Oriented Science and Technology　Postdoctoral researcher

  • 2007/04 - 2010/03
    National Cardiovascular Center Research Institute　Department of Bioengineering　Postdoctoral researcher

  • 2004/04 - 2007/03
    National Cardiovascular Center Research Institute　Department of Bioengineering　Postdoctoral researcher

  • 2006/02 - 2006/03
    University of Bristol　Visiting Researcher

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Education 3

  • Kobe University

    2001/04 - 2004/03

  • Kobe University

    1999/04 - 2001/03

  • Kobe University　Faculty of Engineering　Department of Chemical Science and Engineering

    1995/04 - 1999/03

Committee Memberships 4

  • 日本歯科理工学会　用語検討委員

    2020/04 - Present

  • 日本歯科理工学会　和文誌編集委員

    2018/04 - Present

  • 日本歯科理工学会　代議員

    2015/04 - Present

  • 日本バイオマテリアル学会　評議員

    2015/04 - Present

Professional Memberships 5

  • 日本歯科保存学会

    2018/04 - Present

  • 日本バイオマテリアル学会

    2012/04 - Present

  • 日本歯科理工学会

    2010/04 - Present

  • 日本セラミックス協会

    2004/04 - Present

  • 高分子学会

    2004/04 - Present

Research Interests 2

  • Suface and interace science

  • Biomaterials

Research Areas 1

  • Life sciences / Biomaterials /

Awards 14

  1. 令和5年度 日本歯科理工学会 学術賞

    2024/04　日本歯科理工学会

  2. 1st Place Winner of Oral Presentation

    2022/11　International Dental Materials Congress 2022

  3. 令和2年度 日本歯科理工学会 論文賞

    2021/04　日本歯科理工学会

  4. 医歯薬出版株式会社賞

    2019/04　日本歯科理工学会（第73回学術講演会）

  5. 平成30年度 DMJ Reviewer Award賞

    2019/04　日本歯科理工学会

  6. 平成28年度 Dental Materials Science 賞

    2017/04　日本歯科理工学会

  7. 平成28年度 日本歯科理工学会 論文賞

    2017/04　日本歯科理工学会

  8. 優秀発表賞

    2016/02　第４回日本バイオマテリアル学会中四国シンポジウム

  9. 発表優秀賞

    2013/10　日本歯科理工学会（第62回学術講演会）

  10. 優秀演題賞

    2012/07　第６回ナノ・バイオメディカル学会大会

  11. Young Investigator Award

    2011/05　International Dental Materials Congress 2011

  12. Outstanding Presentation Award for Young Investigator

    2008/12　IUMRS-ICA2008

  13. ベストポスター賞

    2008/06　日本接着学会（第46回年次大会）

  14. Young Investigator’s Award

    2007/09　Asian Bioceramics Symposium 2007

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Papers 101

  1. Bioinspired rhyolite particles as a functional material for lipid regulation in diet-induced obesity Peer-reviewed

    Ahmad Bikharudin, Masahiro Okada, Satoshi Wakai, Ping-Chin Sung, Akihisa Otaka, Nutan Bhingaradiya, YuYang Jiao, Takuya Matsumoto

    Frontiers in Food Science and Technology　6　1964244　2026/09/11

    Publisher: Frontiers Media SA

    DOI： 10.3389/frfst.2026.1964244 　

    eISSN： 2674-1121

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    Many mammals engage in soil-eating behavior, ingesting minerals derived from rocks to obtain nutrients and promote detoxification in the body. Inspired by this animal behavior, we applied rhyolite particles, a natural mineral, as a modulator of lipid metabolism in high-fat diets (HFD) to investigate its effects in regulating lipid digestion and preventing obesity risk, comparing it with activated bamboo charcoal In vitro digestion models, rhyolite particles, regardless of particle size, inhibited the activity of pancreatic lipase and α-amylase, reducing the release of free fatty acids. Similarly, in vivo , rhyolite supplementation suppressed weight gain, improved plasma and hepatic lipid profiles, and maintained the integrity of intestinal and liver tissue. The bacterial composition of the gut microbiota also improved to a near-normal state. Our findings suggest that rhyolite particles, inspired by soil-eating behavior, are a promising natural material for preventing diet-induced obesity through lipid regulation and interaction with the gut microbiota.

  2. Robust adhesion between solid-state hydroxyapatite and bone tissue through surface demineralization Peer-reviewed

    Shichao Xie, Masahiro Okada, Haruyuki Aoyagi, Akihisa Otaka, Xiaofeng Yang, Takayoshi Nakano, Takuya Matsumoto

    Bioactive Materials　57　632-645　2026/03

    Publisher: Elsevier BV

    DOI： 10.1016/j.bioactmat.2025.11.030 　

    ISSN： 2452-199X

  3. Effect of Particle Size of Various Inorganic Milled Particles on Protein Adsorption Behavior Peer-reviewed

    Ahmad Bikharudin, Masahiro Okada, Matsumoto,Takuya

    Evergreen　12　(4)　1987-1994　2025/12

    Publisher: Kyushu University

    DOI： 10.5109/7402630 　

    ISSN： 2189-0420

    eISSN： 2432-5953

  4. Amelioration of Cd-induced bone deterioration by orally administered calcium phosphate Peer-reviewed

    Ping-chin Sung, Ahmad Bikharudin, Masahiro Okada, Randa Musa, Kenta Uchida, Akihisa Otaka, Tadaaki Matsusaka, Aira Matsugaki, Takayoshi Nakano, Takuya Matsumoto

    Applied Food Research　5　(2)　101482-101482　2025/12

    Publisher: Elsevier BV

    DOI： 10.1016/j.afres.2025.101482 　

    ISSN： 2772-5022

  5. Changes in physical properties of decellularized bone after long-term treatment in phosphate-buffered saline Peer-reviewed

    Zi DENG, Masato NAKAGAWA, Yasuhiko MATSUSHIMA, Masahiro OKADA, Yoshitomo HONDA

    Dental Materials Journal　44　(5)　547-556　2025/09/25

    Publisher: Japanese Society for Dental Materials and Devices

    DOI： 10.4012/dmj.2024-345 　

    ISSN： 0287-4547

    eISSN： 1881-1361

  6. Effect of octacalcium phosphate on the release behavior of osteogenic factors from PLGA/PCL microspheres Peer-reviewed

    Tai KIMURA, Ryo HAMAI, Masahiro OKADA, Kaori TSUCHIYA, Kensuke YAMAUCHI, Osamu SUZUKI

    Dental Materials Journal　44　(4)　386-393　2025/07/25

    Publisher: Japanese Society for Dental Materials and Devices

    DOI： 10.4012/dmj.2024-366 　

    ISSN： 0287-4547

    eISSN： 1881-1361

  7. Osteoclast formation in the co-presence of octacalcium phosphate and inorganic phosphorus-containing gelatin in vitro Peer-reviewed

    Ryo HAMAI, Kenya TOMITSUKA, Masahiro OKADA, Kaori TSUCHIYA, Tai KIMURA, Susumu SAKAI, Kensuke YAMAUCHI, Osamu SUZUKI

    Dental Materials Journal　44　(4)　414-426　2025/07/25

    Publisher: Japanese Society for Dental Materials and Devices

    DOI： 10.4012/dmj.2024-367 　

    ISSN： 0287-4547

    eISSN： 1881-1361

  8. Co-precipitating calcium phosphate as oral detoxification of cadmium Peer-reviewed

    Ahmad Bikharudin, Masahiro Okada, Ping-chin Sung, Takuya Matsumoto

    Journal of Hazardous Materials　487　137307-137307　2025/04

    Publisher: Elsevier BV

    DOI： 10.1016/j.jhazmat.2025.137307 　

    ISSN： 0304-3894

  9. Optimizing β-TCP with E-rhBMP-2-infused fibrin for vertical bone regeneration in a mouse calvarium model Peer-reviewed

    Kun Zhao, Mitsuaki Ono, Xindi Mu, Ziyi Wang, Shichao Xie, Tomoko Yonezawa, Masahiro Okada, Takuya Matsumoto, Takuo Kuboki, Toshitaka Oohashi

    Regenerative Biomaterials　12　rbae144　2025/02/11

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/rb/rbae144 　

    eISSN： 2056-3426

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    Abstract Effective reconstruction of large bone defects, particularly in thickness, remains one of the major challenges in orthopedic and dental fields. We previously produced an Escherichia coli-based industrial-scale GMP-grade recombinant human bone morphogenetic protein-2 (E-rhBMP-2) and showed that the combination of E-rhBMP-2 with beta-tricalcium phosphate (β-TCP/E-rhBMP-2) can effectively promote bone reconstruction. However, the limited mechanical strength and poor morphology retention of β-TCP granules are key points that need optimization to obtain more effective grafts and further expand its clinical applications. Therefore, we combined β-TCP/E-rhBMP-2 with fibrin gel to enhance its mechanical properties and usability for vertical bone regeneration. We investigated the mechanical properties and vertical bone regeneration effects of the materials applied, with or without fibrin containing E-rhBMP-2, in a calvarial defect model in mice. Compression tests were conducted to assess the initial stability of the materials. Scanning electron microscopy and Fourier transform infrared spectroscopy were conducted to characterize the presence of fibrin on the scaffold. After 4 and 12 weeks of implantation, micro-computed tomography and histological and immunofluorescent analyses were performed to assess the morphology and volume of the newly formed bone. The fibrin-containing groups had significantly higher initial mechanical strength and higher ability to maintain their morphology in vivo compared to the counterparts without fibrin. However, fibrin gel alone suppressed the bone formation ability of β-TCP/E-rhBMP-2 whereas the presence of high doses of E-rhBMP-2 in fibrin gel resulted in material resorption and enhanced new bone formation. In conclusion, fibrin gel significantly improved the mechanical strength and surgical manageability of the β-TCP/E-rhBMP-2 scaffold, and the addition of E-rhBMP-2 to the fibrin gel further enhanced the vertical bone regeneration and initial structural integrity of the scaffold.

  10. Lipids and Minerals, Interplay in Biomineralization: Nature's Alchemy Peer-reviewed

    Bhingaradiya Nutan, Masahiro Okada, Takuya Matsumoto

    Tissue Engineering Part B: Reviews　30　(6)　571-580　2024/12/30

    Publisher: Mary Ann Liebert Inc

    DOI： 10.1089/ten.teb.2023.0249 　

    ISSN： 1937-3368

    eISSN： 1937-3376

  11. The cell membrane as biofunctional material for accelerated bone repair Peer-reviewed

    Emi Hatano, Nahid Akhter, Risa Anada, Mitsuaki Ono, Toshitaka Oohashi, Takuo Kuboki, Hiroshi Kamioka, Masahiro Okada, Takuya Matsumoto, Emilio Satoshi Hara

    Acta Biomaterialia　186　411-423　2024/09

    Publisher: Elsevier BV

    DOI： 10.1016/j.actbio.2024.07.037 　

    ISSN： 1742-7061

  12. Long-Term Bonding Performance of One-Bottle vs. Two-Bottle Bonding Agents to Lithium Disilicate Ceramics Peer-reviewed

    Masao Irie, Masahiro Okada, Yukinori Maruo, Goro Nishigawa, Takuya Matsumoto

    Polymers　16　(16)　2266-2266　2024/08/09

    Publisher: MDPI AG

    DOI： 10.3390/polym16162266 　

    eISSN： 2073-4360

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    The aim of this study was to compare the long-term bonding performance to lithium disilicate (LDS) ceramic between one-bottle and two-bottle bonding agents. Bonding performance was investigated under these LDS pretreatment conditions: with hydrofluoric acid (HF) only, without HF, with a two-bottle bonding agent (Tokuyama Universal Bond II) only. Shear bond strengths between LDS and nine resin cements (both self-adhesive and conventional adhesive types) were measured at three time periods: after one-day water storage (Base), and after 5000 and 20,000 thermocycles (TC 5k and TC 20k respectively). Difference in degradation between one- and two-bottle bonding agents containing the silane coupling agent was compared by high-performance liquid chromatography. With HF pretreatment, bond strengths were not significantly different among the three time periods for each resin cement. Without HF, ESTECEM II and Super-Bond Universal showed significantly higher values than others at TC 5k and TC 20k when treated with the recommended bonding agents, especially at TC 20k. Difference in degradation between one- and two-bottle bonding agents containing the silane coupling agent was compared by high-performance liquid chromatography (HPLC). For both cements, these values at TC 20k were also not significantly different from pretreatment with only Tokuyama Universal Bond II. For LDS, long-term bond durability could be maintained by pretreatment with Tokuyama Universal Bond II instead of the hazardous HF.

  13. Mid-infrared passive spectroscopic imaging for visualizing tooth quality Peer-reviewed

    So Yamashita, Masahiro Okada, Takuya Matsumoto, Ichiro Ishimaru

    Journal of Materials Chemistry B　12　(36)　9050-9055　2024/08

    Publisher: Royal Society of Chemistry (RSC)

    DOI： 10.1039/d4tb00280f 　

    ISSN： 2050-750X

    eISSN： 2050-7518

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    A mid-infrared passive spectroscopic 2-D imaging system was developed to determine structural changes of tooth two-dimensionally and non-invasively.

  14. Water‐Mediated On‐Demand Detachable Solid‐State Adhesive of Porous Hydroxyapatite for Internal Organ Retractions Peer-reviewed

    Masahiro Okada, Shi Chao Xie, Yusuke Kobayashi, Hiroaki Yanagimoto, Daisuke Tsugawa, Masaru Tanaka, Takayoshi Nakano, Takumi Fukumoto, Takuya Matsumoto

    Advanced Healthcare Materials　13　(19)　2304616　2024/05/20

    Publisher: Wiley

    DOI： 10.1002/adhm.202304616 　

    ISSN： 2192-2640

    eISSN： 2192-2659

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    Abstract Novel adhesives for biological tissues offer an advanced surgical approach. Here, the authors report the development and application of solid‐state adhesives consisting of porous hydroxyapatite (HAp) biocompatible ceramics as novel internal organ retractors. The operational principles of the porous solid‐state adhesives are experimentally established in terms of water migration from biological soft tissues into the pores of the adhesives, and their performance is evaluated on several soft tissues with different hydration states. As an example of practical medical utility, HAp adhesive devices demonstrate the holding ability of porcine livers and on‐demand detachability in vivo, showing great potential as internal organ retractors in laparoscopic surgery.

  15. Investigation on bacterial capture and antibacterial properties of acid-treated Ti surface Peer-reviewed

    Haruyuki Aoyagi, Masahiro Okada, Hiroaki Yanagimoto, Takuya Matsumoto

    Dental Materials　40　(2)　318-326　2024/02

    Publisher: Elsevier BV

    DOI： 10.1016/j.dental.2023.11.018 　

    ISSN： 0109-5641

  16. Solid-state inorganic and metallic adhesives for soft biological tissues Peer-reviewed

    Masahiro Okada, Takuya Matsumoto

    Japanese Dental Science Review　59　439-445　2023/12/23

    Publisher: Elsevier BV

    DOI： 10.1016/j.jdsr.2023.11.003 　

    ISSN： 1882-7616

  17. Fabrication of initial trabecular bone inspired three-dimensional structure with cell membrane nanofragments Peer-reviewed

    Koichi Kadoya, Emilio Satoshi Hara, Masahiro Okada, Yu Yang Jiao, Takayoshi Nakano, Akira Sasaki, Takuya Matsumoto

    Regenerative Biomaterials　10　rbac088　2023/12/22

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/rb/rbac088 　

    ISSN： 2056-3418

    eISSN： 2056-3426

  18. Fabrication of a Fish-Bone-Inspired Inorganic–Organic Composite Membrane Peer-reviewed

    YuYang Jiao, Masahiro Okada, Bhingaradiya Nutan, Noriyuki Nagaoka, Ahmad Bikharudin, Randa Musa, Takuya Matsumoto

    Polymers　15　(20)　4190-4190　2023/10/23

    Publisher: MDPI AG

    DOI： 10.3390/polym15204190 　

    eISSN： 2073-4360

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    Biological materials have properties like great strength and flexibility that are not present in synthetic materials. Using the ribs of crucian carp as a reference, we investigated the mechanisms behind the high mechanical properties of this rib bone, and found highly oriented layers of calcium phosphate (CaP) and collagen fibers. To fabricate a fish-rib-bone-mimicking membrane with similar structure and mechanical properties, this study involves (1) the rapid synthesis of plate-like CaP crystals, (2) the layering of CaP–gelatin hydrogels by gradual drying, and (3) controlling the shape of composite membranes using porous gypsum molds. Finally, as a result of optimizing the compositional ratio of CaP filler and gelatin hydrogel, a CaP filler content of 40% provided the optimal mechanical properties of toughness and stiffness similar to fish bone. Due to the rigidity, flexibility, and ease of shape control of the composite membrane materials, this membrane could be applied as a guided bone regeneration (GBR) membrane.

  19. Shear Bond Strength of Resin Luting Materials to Lithium Disilicate Ceramic: Correlation between Flexural Strength and Modulus of Elasticity Peer-reviewed

    Masao Irie, Masahiro Okada, Yukinori Maruo, Goro Nishigawa, Takuya Matsumoto

    Polymers　15　(5)　1128-1128　2023/02/23

    Publisher: MDPI AG

    DOI： 10.3390/polym15051128 　

    eISSN： 2073-4360

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    This study investigates the effect of the curing mode (dual-cure vs. self-cure) of resin cements (four self-adhesive and seven conventional cements) on their flexural strength and flexural modulus of elasticity, alongside their shear bond strength to lithium disilicate ceramics (LDS). The study aims to determine the relationship between the bond strength and LDS, and the flexural strength and flexural modulus of elasticity of resin cements. Twelve conventional or adhesive and self-adhesive resin cements were tested. The manufacturer’s recommended pretreating agents were used where indicated. The shear bond strengths to LDS and the flexural strength and flexural modulus of elasticity of the cement were measured immediately after setting, after one day of storage in distilled water at 37 °C, and after 20,000 thermocycles (TC 20k). The relationship between the bond strength to LDS, flexural strength, and flexural modulus of elasticity of resin cements was investigated using a multiple linear regression analysis. For all resin cements, the shear bond strength, flexural strength, and flexural modulus of elasticity were lowest immediately after setting. A clear and significant difference between dual-curing and self-curing modes was observed in all resin cements immediately after setting, except for ResiCem EX. Regardless of the difference of the core-mode condition of all resin cements, flexural strengths were correlated with the LDS surface upon shear bond strengths (R2 = 0.24, n = 69, p < 0.001) and the flexural modulus of elasticity was correlated with them (R2 = 0.14, n = 69, p < 0.001). Multiple linear regression analyses revealed that the shear bond strength was 17.877 + 0.166, the flexural strength was 0.643, and the flexural modulus was (R2 = 0.51, n = 69, p < 0.001). The flexural strength or flexural modulus of elasticity may be used to predict the bond strength of resin cements to LDS.

  20. Preparation of mineralized pericardium by alternative soaking for soft–hard interregional tissue application Peer-reviewed

    Mika Suzuki, Tsuyoshi Kimura, Yuta Nakano, Mako Kobayashi, Masahiro Okada, Takuya Matsumoto, Naoko Nakamura, Yoshihide Hashimoto, Akio Kishida

    Journal of Biomedical Materials Research Part A　111　(2)　198-208　2023/02/23

    Publisher: Wiley

    DOI： 10.1002/jbm.a.37445 　

    ISSN： 1549-3296

    eISSN： 1552-4965

  21. Important roles of odontoblast membrane phospholipids in early dentin mineralization Peer-reviewed

    Risa Anada, Emilio Satoshi Hara, Noriyuki Nagaoka, Masahiro Okada, Hiroshi Kamioka, Takuya Matsumoto

    Journal of Materials Chemistry B　11　(3)　657-666　2023/01/21

    Publisher: Royal Society of Chemistry (RSC)

    DOI： 10.1039/d2tb02351b 　

    ISSN： 2050-750X

    eISSN： 2050-7518

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    The objective of this study was to first identify the timing and location of early mineralization of mouse first molar, and subsequently, to characterize the nucleation site for mineral formation...

  22. Distinct Morphologies of Bone Apatite Clusters in Endochondral and Intramembranous Ossification Peer-reviewed

    Emilio Satoshi Hara, Noriyuki Nagaoka, Masahiro Okada, Takayoshi Nakano, Takuya Matsumoto

    Advanced Biology　6　(11)　2200076-2200076　2022/11

    Publisher: Wiley

    DOI： 10.1002/adbi.202200076 　

    ISSN： 2701-0198

    eISSN： 2701-0198

  23. Shear bond strength of resin cement on moist dentin and its relation to the flexural strength of resin cement Peer-reviewed

    Irie, M., Okada, M., Yoshimoto, A., Maruo, Y., Nishigawa, G., Matsumoto, T.

    Dental Materials Journal　41　(3)　429-439　2022/05/25

    Publisher: Japanese Society for Dental Materials and Devices

    DOI： 10.4012/dmj.2021-278 　

    ISSN： 1881-1361 0287-4547

    eISSN： 1881-1361

  24. Self-adhering implantable device of titanium: Enhanced soft-tissue adhesion by sandblast pretreatment Peer-reviewed

    Atsushi Yabe, Masahiro Okada, Emilio Satoshi Hara, Yasuhiro Torii, Takuya Matsumoto

    Colloids and Surfaces B: Biointerfaces　211　112283-112283　2022/03

    Publisher: Elsevier BV

    DOI： 10.1016/j.colsurfb.2021.112283 　

    ISSN： 0927-7765

  25. Immediate soft-tissue adhesion and the mechanical properties of the Ti–6Al–4V alloy after long-term acid treatment International-journal Peer-reviewed

    Yaming Wang, Masahiro Okada, Shi Chao Xie, Yu Yang Jiao, Emilio Satoshi Hara, Hiroaki Yanagimoto, Takumi Fukumoto, Takuya Matsumoto

    Journal of Materials Chemistry B　9　(39)　8348-8354　2021/10

    Publisher: Royal Society of Chemistry (RSC)

    DOI： 10.1039/d1tb00919b 　

    ISSN： 2050-750X

    eISSN： 2050-7518

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    A metallic solid-state adhesive for biological soft tissues was fabricated using Ti–6Al–4V alloys, and the influence of the minor β phase and the small amount of Al in the α phase are reported.

  26. Re-Evaluation of Initial Bone Mineralization from an Engineering Perspective International-journal Peer-reviewed

    Emilio Satoshi Hara, Masahiro Okada, Noriyuki Nagaoka, Takayoshi Nakano, Takuya Matsumoto

    Tissue Engineering Part B: Reviews　28　(1)　246-255　2021/03/29

    Publisher: Mary Ann Liebert Inc

    DOI： 10.1089/ten.teb.2020.0352 　

    ISSN： 1937-3368

    eISSN： 1937-3376

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    Bone regeneration was one of the earliest fields to develop in the context of tissue regeneration, and currently, repair of small-sized bone defects has reached a high success rate. Future researches are expected to incorporate more advanced techniques toward achieving rapid bone repair and modulation of the regenerated bone quality. For these purposes, it is important to have a more integrative understanding of the mechanisms of bone formation and maturation from multiple perspectives and to incorporate these new concepts into the development and designing of novel materials and techniques for bone regeneration. This review focuses on the analysis of the earliest stages of bone tissue development from the biology, material science, and engineering perspectives for a more integrative understanding of bone formation and maturation, and for the development of novel biology-based engineering approaches for tissue synthesis in vitro. More specifically, the authors describe the systematic methodology that allowed the understanding of the different nucleation sites in intramembranous and endochondral ossification, the space-making process for mineral formation and growth, as well as the process of apatite crystal cluster growth in vivo in the presence of suppressing biomolecules. Impact Statement A detailed understanding of the developmental process of bone tissue leads to the acquisition of useful information for the bone tissue fabrication. This review summarizes the study of the calcification process of the calvaria and epiphyses from an engineering perspective and provides useful information for the realization of bone tissue biofabrication. Here, we describe the new mechanism of space formation for mineralization such as rupture of chondrocytes and disruption of cell-cell adhesion. We also describe the roles of nucleation site such as cell membrane nanofragments and matrix vesicles.

  27. Coating method for smooth and reinforced surface layer of highly translucent zirconia Peer-reviewed

    Fujii, Y., Okada, M., Taketa, H., Matsumoto, T.

    Dental Materials Journal　40　(2)　532-537　2021/03/25

    Publisher: Japanese Society for Dental Materials and Devices

    DOI： 10.4012/dmj.2020-108 　

    ISSN： 1881-1361 0287-4547

    eISSN： 1881-1361

  28. Bone Mineral Analogue Ceramic Block as an Instant Adhesive to Biological Soft Tissue Peer-reviewed

    Sugiura, Y., Okada, M., Hirano, K., Matsumoto, T.

    Advanced Materials Interfaces　8　(6)　2170033-2170033　2021/03

    Publisher: Wiley

    DOI： 10.1002/admi.202002032 　

    ISSN： 2196-7350

    eISSN： 2196-7350

  29. Nanostructural analysis of distinct nucleation sites in pathological mineralization Peer-reviewed

    Emilio Satoshi Hara, Susumu Oozawa, Noriyuki Nagaoka, Masahiro Okada, Shingo Kasahara, Takuya Matsumoto

    Materials Advances　2　(13)　4423-4431　2021

    DOI： 10.1039/d1ma00273b 　

    eISSN： 2633-5409

  30. Micro-Architectural Investigation of Teleost Fish Rib Inducing Pliant Mechanical Property. International-journal Peer-reviewed

    Yu Yang Jiao, Masahiro Okada, Emilio Satoshi Hara, Shi Chao Xie, Noriyuki Nagaoka, Takayoshi Nakano, Takuya Matsumoto

    Materials (Basel, Switzerland)　13　(22)　5099　2020/11/13

    DOI： 10.3390/ma13225099 　

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    Despite the fact that various reports have been discussing bone tissue regeneration, precise bone tissue manipulation, such as controlling the physical properties of the regenerated bone tissue, still remains a big challenge. Here, we focused on the teleost fish ribs showing flexible and tough mechanical properties to obtain a deeper insight into the structural and functional features of bone tissue from different species, which would be valuable for the superior design of bone-mimicking materials. Herein, we examined their compositions, microstructure, histology, and mechanical properties. The first rib of Carassius langsdorfii showed a higher Young's modulus with a small region of chondrocyte clusters compared with other smaller ribs. In addition, highly oriented collagen fibers and osteocytes were observed in the first rib, indicating that the longest first rib would be more mature. Moreover, the layer-by-layer structure of the oriented bone collagen was observed in each rib. These microarchitectural and compositional findings of fish rib bone would give one the useful idea to reproduce such a highly flexible rib bone-like material.

  31. Cellular fragments as biomaterial for rapid in vitro bone-like tissue synthesis Peer-reviewed

    Akhter, M.N., Hara, E.S., Kadoya, K., Okada, M., Matsumoto, T.

    International Journal of Molecular Sciences　21　(15)　5327　2020/08/27

    DOI： 10.3390/ijms21155327 　

    ISSN： 1422-0067 1661-6596

  32. Titanium as an Instant Adhesive for Biological Soft Tissue Peer-reviewed

    Masahiro Okada, Emilio Satoshi Hara, Atsushi Yabe, Kei Okada, Yo Shibata, Yasuhiro Torii, Takayoshi Nakano, Takuya Matsumoto

    Advanced Materials Interfaces　7　(9)　1902089-1902089　2020/05/01

    Publisher: Wiley

    DOI： 10.1002/admi.201902089 　

    ISSN： 2196-7350

    eISSN： 2196-7350

  33. Analysis of Bone Regeneration Based on the Relationship between the Orientations of Collagen and Apatite in Mouse Femur Peer-reviewed

    Ryosuke Ozasa, Mayuko Nakatsu, Atsushi Moriguchi, Kyohei Sasaki, Takuya Ishimoto, Masahiro Okada, Takuya Matsumoto, Takayoshi Nakano

    MATERIALS TRANSACTIONS　61　(2)　381-386　2020/02/01

    Publisher: Japan Institute of Metals

    DOI： 10.2320/matertrans.mt-m2019341 　

    ISSN： 1345-9678

    eISSN： 1347-5320

  34. Toughening of highly translucent zirconia by monoclinic Zro2 and Sio2 particle coating Peer-reviewed

    Uno, S., Okada, M., Taketa, H., Torii, Y., Matsumoto, T.

    Dental Materials Journal　39　(2)　295-301　2020/01/30

    DOI： 10.4012/dmj.2018-415 　

    ISSN： 1881-1361 0287-4547

  35. Vibratory splint therapy for decreasing sleep clenching: A pilot study Peer-reviewed

    Emilio Satoshi Hara, Andrea Lusvarghi Witzel, Hajime Minakuchi, Carlos Eduardo de Pitta, Rosane Tronquin Gallo, Masahiro Okada, Takuya Matsumoto, Takuo Kuboki, Marcelo Costa Bolzan

    CRANIO®　38　(1)　15-21　2020/01/02

    DOI： 10.1080/08869634.2018.1488652 　

    ISSN： 0886-9634

    eISSN： 2151-0903

  36. Application of hydroxyapatite nanoparticle-assembled powder using basic fibroblast growth factor as a pulp-capping agent Peer-reviewed

    Imura, K., Hashimoto, Y., Okada, M., Yoshikawa, K., Yamamoto, K.

    Dental Materials Journal　38　(5)　713-720　2019/09/27

    DOI： 10.4012/dmj.2018-198 　

    ISSN： 1881-1361 0287-4547

  37. Improvement of mechanical properties of Y-TZP by thermal annealing with monoclinic zirconia nanoparticle coating. International-journal Peer-reviewed

    Masahiro Okada, Hiroaki Taketa, Emilio Satoshi Hara, Yasuhiro Torii, Masao Irie, Takuya Matsumoto

    Dental materials : official publication of the Academy of Dental Materials　35　(7)　970-978　2019/07/01

    DOI： 10.1016/j.dental.2019.04.002 　

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    OBJECTIVE: To assess whether a thermal annealing with a monoclinic zirconia (mZrO2) nanoparticle coating can improve the reliability of sandblasted yttria-stabilized tetragonal zirconia polycrystals (Y-TZP) and maintain its mechanical strength. METHODS: Commercially available Y-TZP (Lava Frame, 3M Dental Products) disks were sintered and surface-treated as follows: AS (as sintered, with no treatment); SB (sandblasting); SB-TA (sandblasting followed by thermal annealing at 1000 °C); and SB-mZr-TA (sandblasting followed by thermal annealing at 1000 °C with the mZrO2 nanoparticle coating). The mZrO2 nanoparticles of 21 nm in size were prepared by a hydrothermal method, and coated onto Y-TZP sintered disks as a 5 g/L ethanol dispersion. Biaxial flexural strength (S) was measured using the piston-on-three-ball test, and reliability was evaluated by the Weibull modulus (m). RESULTS: Biaxial flexural tests showed a significant increase in the strength of Group SB (SSB = 1445 ± 191 MPa) compared with Group AS (SAS = 1071 ± 112 MPa). The thermal annealing improved the reliabilities of the sandblasted Y-TZP (mSB-TA = 20.14 and mSB-mZr-TA = 21.33), as compared with Group SB (mSB = 7.77). However, the conventional thermal annealing without the mZrO2 coating caused a significant decrease in the strength of sandblasted Y-TZP (SSB-TA = 1273 ± 65 MPa). Importantly, the mZrO2 coating prevented the decrease in the strength caused by conventional thermal annealing (SSB-mZr-TA = 1379 ± 65 MPa). SIGNIFICANCE: The thermal annealing with the mZrO2 nanoparticle coating can improve the reliability of sandblasted Y-TZP and maintain its mechanical strength, which would otherwise be decreased by the conventional annealing process.

  38. Biomimetic mineralization using matrix vesicle nanofragments Peer-reviewed

    Yosuke Kunitomi, Emilio Satoshi Hara, Masahiro Okada, Noriyuki Nagaoka, Takuo Kuboki, Takayoshi Nakano, Hiroshi Kamioka, Takuya Matsumoto

    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A　107　(5)　1021-1030　2019/05

    DOI： 10.1002/jbm.a.36618 　

    ISSN： 1549-3296

    eISSN： 1552-4965

  39. Intermediate water on calcium phosphate minerals: ITS origin and role in crystal growth Peer-reviewed

    Okada, M., Hara, E.S., Kobayashi, D., Kai, S., Ogura, K., Tanaka, M., Matsumoto, T.

    ACS Applied Bio Materials　2　(3)　981-986　2019/02/18

    Publisher: American Chemical Society ({ACS})

    DOI： 10.1021/acsabm.9b00014 　

    ISSN： 2576-6422

  40. Acidic pre-conditioning enhances the stem cell phenotype of human bone marrow stem/progenitor cells Peer-reviewed

    Hazehara-Kunitomo, Y., Hara, E.S., Ono, M., Aung, K.T., Komi, K., Pham, H.T., Akiyama, K., Okada, M., Oohashi, T., Matsumoto, T., Kuboki, T.

    International Journal of Molecular Sciences　20　(5)　1097　2019/01/19

    DOI： 10.3390/ijms20051097 　

    ISSN： 1422-0067 1661-6596

  41. Biomimetic mineralization using matrix vesicle nanofragments, Journal of Biomedical Materials Research Part A

    Yosuke Kunitomi, Emilio Satoshi Hara, Masahiro Okada, Noriyuki Nagaoka, Takuo Kuboki, Takayoshi Nakano, Hiroshi Kamioka, Takuya Matsumoto

    Journal of Biomedical Materials Research Part A　2019/01

    DOI： 10.1021/acsbiomaterials.7b00962 　

  42. Optimal sandblasting conditions for conventional-type yttria-stabilized tetragonal zirconia polycrystals. International-journal Peer-reviewed

    Masahiro Okada, Hiroaki Taketa, Yasuhiro Torii, Masao Irie, Takuya Matsumoto

    Dental materials : official publication of the Academy of Dental Materials　35　(1)　169-175　2019/01/01

    DOI： 10.1016/j.dental.2018.11.009 　

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    OBJECTIVE: To assess the influence of sandblasting conditions applied to conventional-type yttria-stabilized tetragonal zirconia polycrystal (Y-TZP) on surface roughness, phase transformation, and biaxial flexural strength. METHODS: Commercially available Y-TZP (Lava Frame, 3M Dental Products) disks were used after sintering (specimen dimensions: 14mm in diameter and 1.2mm in thickness). The surfaces of specimens were ground, and then sandblast treatments were conducted at different pressures (0.20, 0.25, 0.30, 0.35 and 0.40MPa) and distances (1, 5, 10 and 20mm) with 50μm alumina particles. Surface roughness measurements were performed and scanning electron microscopy (SEM) images were taken for surface characterizations. Phase transformation of Y-TZP was identified by X-ray diffraction (XRD). Biaxial flexural strength was measured using the piston-on-three-ball test. RESULTS: The surface roughness increased significantly by increasing the sandblasting pressure, and microcracks were observed at high sandblasting pressure at 0.40MPa. The shortest sandblasting distance (1mm) was not effective to increase the surface roughness compared with other sandblasting distances. A tetragonal to monoclinic phase transformation was observed after grinding. The degree of the phase transformation tended to increase with sandblasting pressure, and significant effect was independent of the sandblasting distance. The biaxial flexural test showed improved mechanical strengths for the samples after sandblasting at 0.20-0.35MPa, with the maximum strength at 0.25MPa. Sandblasting at 0.40MPa decreased the strength as compared with 0.25MPa. SIGNIFICANCE: The surface roughness increased with increasing the sandblasting pressure, whereas there was an optimal sandblasting pressure range to increase biaxial flexural strength of Y-TZP.

  43. Rapid bioinspired mineralization using cell membrane nanofragments and alkaline milieu Peer-reviewed

    Emilio Satoshi Hara, Masahiro Okada, Takuo Kuboki, Takayoshi Nakano, Takuya Matsumoto

    Journal of Materials Chemistry B　6　(38)　6153-6161　2018/09/11

    Publisher: Royal Society of Chemistry ({RSC})

    DOI： 10.1039/C8TB01544A 　

    ISSN： 2050-750X

    eISSN： 2050-7518

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    <p>Bone formation<italic>in vivo</italic>occurs in alkaline environment, which determines the optimal p<italic>K</italic>aof phosphatases, the optimal amount of calcium for mineral precipitation, and the spherical shape of initial minerals. Manipulation of environmental pH for<italic>in vitro</italic>synthesis of bone-like tissue, showed a markedly rapid mineralization with nanofragments and alkaline milieu.</p>

  44. Bioinspired Mineralization Using Chondrocyte Membrane Nanofragments Peer-reviewed

    Hara, E.S., Okada, M., Nagaoka, N., Hattori, T., Kuboki, T., Nakano, T., Matsumoto, T.

    ACS Biomaterials Science and Engineering　4　(2)　617-625　2018/01/16

    Publisher: ACS Publications

    DOI： 10.1021/acsbiomaterials.7b00962 　

    ISSN： 2373-9878

  45. Fabrication of Hydroxyapatite Nanofibers with High Aspect Ratio via Low-Temperature Wet Precipitation Methods Under Acidic Conditions

    Masahiro Okada, Emilio Satoshi Hara, Takuya Matsumoto

    Biomineralization　211-218　2018

    Publisher: Springer Singapore

    DOI： 10.1007/978-981-13-1002-7_22 　

  46. Chondrocyte burst promotes space for mineral expansion Peer-reviewed

    Emilio Satoshi Hara, Masahiro Okada, Noriyuki Nagaoka, Takako Hattori, Letycia Mary Iida, Takuo Kuboki, Takayoshi Nakano, Takuya Matsumoto

    Integrative Biology　10　(1)　57-66　2018

    Publisher: Oxford University Press (OUP)

    DOI： 10.1039/c7ib00130d 　

    ISSN： 1757-9694

    eISSN： 1757-9708

  47. Resin adhesion strengths to zirconia ceramics after primer treatment with silane coupling monomer or oligomer Peer-reviewed

    Okada, Masahiro, Inoue, Kazusa, Irie, Masao, Taketa, Hiroaki, Torii, Yasuhiro, Matsumoto, Takuya

    Dental materials journal　36　(5)　600-605　2017/09/26

    Publisher: The Japanese Society for Dental Materials and Devices

    DOI： 10.4012/dmj.2016-334 　

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    <p>Resin bonding to zirconia ceramics is difficult to achieve using the standard methods for conventional silica-based dental ceramics, which employ silane coupling monomers as primers. The hypothesis in this study was that a silane coupling oligomer —a condensed product of silane coupling monomers— would be a more suitable primer for zirconia. To prove this hypothesis, the shear bond strengths between a composite resin and zirconia were compared after applying either a silane coupling monomer or oligomer. The shear bond strength increased after applying a non-activated ethanol solution of the silane coupling oligomer compared with that achieved when applying the monomer. Thermal treatment of the zirconia at 110°C after application of the silane coupling agents was essential to improve the shear bond strength between the composite resin cement and zirconia.</p>

  48. The effect of Mg and Sr on the crystallinity of bones evaluated through Raman spectroscopy and laser ablation-ICPMS analysis Peer-reviewed

    Tanaka, Y.-K., Yajima, N., Okada, M., Matsumoto, T., Higuchi, Y., Miyazaki, S., Yamato, H., Hirata, T.

    Analyst　142　(22)　4265-4278　2017/09/07

    Publisher: Royal Society of Chemistry

    DOI： 10.1039/c7an00734e 　

    ISSN： 1364-5528 0003-2654

  49. Biocompatible nanostructured solid adhesives for biological soft tissues Peer-reviewed

    Okada, M., Nakai, A., Hara, E.S., Taguchi, T., Nakano, T., Matsumoto, T.

    Acta Biomaterialia　57　404-413　2017/07/15

    Publisher: Elsevier

    DOI： 10.1016/j.actbio.2017.05.014 　

    ISSN： 1878-7568 1742-7061

  50. Adsorption and desorption behaviors of cetylpyridinium chloride on hydroxyapatite nanoparticles with different morphologies Peer-reviewed

    Okada, M., Hiramatsu, D., Okihara, T., Matsumoto, T.

    Dental Materials Journal　35　(4)　651-658　2016/07

    Publisher: The Japanese Society for Dental Materials and Devices

    DOI： 10.4012/dmj.2015-420 　

    ISSN： 1881-1361 0287-4547

  51. Cell survival and gene expression under compressive stress in a three-dimensional in vitro human periodontal ligament-like tissue model Peer-reviewed

    Liao, W., Okada, M., Inami, K., Hashimoto, Y., Matsumoto, N.

    Cytotechnology　68　(2)　249-260　2016/03/01

    Publisher: Springer

    DOI： 10.1007/s10616-014-9775-3 　

    ISSN： 1573-0778 0920-9069

  52. Fabrication methods of hydroxyapatite nanocomposites

    Okada, M., Matsumoto, T.

    Nano Biomedicine　8　(1)　15-26　2016

    Publisher: Nano Biomedical Society

    ISSN： 2185-4734 1883-5198

  53. Improvement of photocatalytic activity of TiO2 coating by the modified sol-gel method Peer-reviewed

    Awata, M., Okada, M., Nambu, T., Matsumoto, N.

    Nano Biomedicine　7　(2)　51-62　2015/12/30

    Publisher: Nano Biomedical Society

    ISSN： 2185-4734 1883-5198

  54. Novel 3D-printed device for the simple preparation of hydrogel beads Peer-reviewed

    Rahman, K.A., Sathi, G.A., Taketa, H., Farahat, M., Okada, M., Torii, Y., Matsumoto, T.

    3D Printing and Additive Manufacturing　2　(1)　5-11　2015/03/16

    Publisher: Mary Ann Liebert, Inc. 140 Huguenot Street, 3rd Floor New Rochelle, NY 10801 USA

    DOI： 10.1089/3dp.2014.0023 　

    ISSN： 2329-7670 2329-7662

  55. Synthesis and antibacterial evaluation of calcinated Ag-doped nano-hydroxyapatite with dispersibility International-journal

    Furuzono, Tsutomu, Motaharul, Mazumder, Kogai, Yasumichi, Azuma, Yoshinao, Sawa, Yoshiki

    The International journal of artificial organs　38　(5)　251-258　2015

    Publisher: SAGE Publications Sage UK: London, England

    eISSN： 1724-6040

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    PURPOSE: Dispersible hydroxyapatite (HAp) nanoparticles are very useful for applying a monolayer to implantable medical devices using the nano-coating technique. To improve tolerance to infection on implanted medical devices, silver-doped HAp (Ag-HAp) nanoparticles with dispersiblity and crystallinity were synthesized, avoiding calcination-induced sintering, and evaluated for antibacterial activity. METHODS: The Ca10-xAgx(PO4)6(OH)2 with x = 0 and 0.2 were prepared by wet chemical processing at 100°C. Before calcination at 700°C for 2 h, two kinds of anti-sintering agents, namely a Ca(NO3)2 (Ca salt) and a polyacrylic acid/Ca salt mixture (PAA-Ca), were used. Escherichia coli was used to evaluate the antibacterial activity of the nanopowder. RESULTS: When PAA-Ca was used as an anti-sintering agent in calcination to prepare the dispersible nanoparticles, strong metallic Ag peaks were observed at 38.1° and 44.3° (2θ) in the X-ray diffraction (XRD) profile. However, the Ag peak was barely observed when Ca salt was used alone as the anti-sintering agent. Thus, using Ca salt alone was more effective for preparation of dispersible Ag-HAp than PAA-Ca. The particle average size of Ag-HAp with 0.5 mol% of Ag content was found to be 325 ± 70 nm when the formation of large particleaggregations was prevented, as determined by dynamic light scattering instrument. The antibacterial activity of the Ag-HAp nanoparticles possessing 0.5 mol% against E. coli was greater than 90.0%. CONCLUSIONS: Dispersible and crystalline nano Ag-HAp can be obtained by using Ca salt alone as an anti-sintering agent. The nanoparticles showed antibacterial activity.

  56. Synthesis and modification of apatite nanoparticles for use in dental and medical applications

    Okada, M., Matsumoto, T.

    Japanese Dental Science Review　51　(4)　85-95　2015

    Publisher: Elsevier

    DOI： 10.1016/j.jdsr.2015.03.004 　

    ISSN： 2213-6851 1882-7616

  57. Fabrication of dispersible calcium phosphate nanocrystals via a modified Pechini method under non-stoichiometric conditions Peer-reviewed

    Omori, Y., Okada, M., Takeda, S., Matsumoto, N.

    Materials Science and Engineering C　42　562-568　2014/09/01

    Publisher: Elsevier

    DOI： 10.1016/j.msec.2014.05.071 　

    ISSN： 0928-4931

  58. Influence of calcination conditions on dispersibility and phase composition of hydroxyapatite crystals calcined with anti-sintering agents Peer-reviewed

    Okada, M., Omori, Y., Awata, M., Shirai, T., Matsumoto, N., Takeda, S., Furuzono, T.

    Journal of Nanoparticle Research　16　(7)　2469-2469　2014/06/06

    Publisher: Springer

    DOI： 10.1007/s11051-014-2469-0 　

    ISSN： 1572-896X 1388-0764

  59. Prevention of catheter infection using a biodegradable tissue adhesive composed of human serum albumin and disuccinimidyl tartrate Peer-reviewed

    Taguchi, T., Okada, M., Kogai, Y., Masuda, M., Shimomura, Y., Inoue, M., Ito, T., Hamahata, T., Funatogawa, K., Kirikae, T., Furuzono, T.

    Journal of Bioactive and Compatible Polymers　29　(3)　284-297　2014/05/26

    Publisher: Sage Publications Sage UK: London, England

    DOI： 10.1177/0883911514528409 　

    ISSN： 1530-8030 0883-9115

  60. A novel strategy for preparing nanoporous biphasic calcium phosphate of controlled composition via a modified nanoparticle-assembly method Peer-reviewed

    Fujiwara, K., Okada, M., Takeda, S., Matsumoto, N.

    Materials Science and Engineering C　35　(1)　259-266　2014/02/01

    Publisher: Elsevier

    DOI： 10.1016/j.msec.2013.11.019 　

    ISSN： 0928-4931

  61. Preparation and characterization of low-crystallized hydroxyapatitenanoporous plates and granules Peer-reviewed

    Uehira, M., Okada, M., Takeda, S., Matsumoto, N.

    Applied Surface Science　287　195-202　2013/12/15

    Publisher: Elsevier

    DOI： 10.1016/j.apsusc.2013.09.117 　

    ISSN： 0169-4332

  62. Expansion of nanosized pores in low-crystallinity nanoparticle-assembled plates via a thermally induced increase in solid-state density Peer-reviewed

    Okada, M., Fujiwara, K., Uehira, M., Matsumoto, N., Takeda, S.

    Journal of Colloid and Interface Science　405　58-63　2013/09/01

    Publisher: Elsevier

    DOI： 10.1016/j.jcis.2013.05.022 　

    ISSN： 0021-9797 1095-7103

  63. Effect of interfacial serum proteins on melanoma cell adhesion to biodegradable poly(l-lactic acid) microspheres coated with hydroxyapatite Peer-reviewed

    Shinto, H., Hirata, T., Fukasawa, T., Fujii, S., Maeda, H., Okada, M., Nakamura, Y., Furuzono, T.

    Colloids and Surfaces B: Biointerfaces　108　8-15　2013/08/01

    Publisher: Elsevier

    DOI： 10.1016/j.colsurfb.2013.02.021 　

    ISSN： 0927-7765 1873-4367

  64. In vitro human periodontal ligament-like tissue formation with porous poly-l-lactide matrix International-journal Peer-reviewed

    Liao, Wen, Okada, Masahiro, Sakamoto, Fumito, Okita, Naoya, Inami, Kaoru, Nishiura, Aki, Hashimoto, Yoshiya, Matsumoto, Naoyuki

    Materials Science and Engineering: C　33　(6)　3273-3280　2013/08/01

    Publisher: Elsevier

    DOI： 10.1016/j.msec.2013.04.008 　

    ISSN： 0928-4931

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    This study aimed to establish an in vitro human periodontal ligament-like tissue (HPdLLT) by three-dimensional culturing of human periodontal ligament fibroblasts (HPdLFs) in a porous poly-L-lactide (PLLA) matrix modified hydrophilically with ammonia solution. After ammonia modification, the surface roughness and culture-medium-soaking-up ability of the PLLA matrix increased, whereas the contact angle of water drops decreased. The thickness, porosity, and pore size of the PLLA matrix were 400±50 μm, 83.3%, and 75-150 μm, respectively. HPdLFs (1×10(5) cells) were seeded on the modified PLLA matrix and centrifuged to facilitate seeding into its interior and cultured for 14 days. Scanning electron microscope (SEM) observation, proliferation assay, picrosirius-red staining, and real-time polymerase chain reaction (RT-PCR) for type-1 collagen (COL1), periodontal ligament associated protein-1 (PLAP-1), fibroblast growth factor-2 (FGF-2), and alkaline phosphatase (ALP) mRNA were conducted on days 1, 3, 7, and 14. HPdLFs were observed entirely from the surface to the rear side of the matrix. Cell proliferation analysis, SEM observation, and picrosirius-red staining showed both progressive growth of 3D-cultured HPdLFs and extracellular matrix maturation by the secretion of COL1 and type 3 collagen (COL3) from days 1 to 14. Expressions of COL1, PLAP-1, and FGF-2 mRNA suggested the formation of cellular components and supplementation of extracellular components. Expressions of ALP, COL1, and PLAP-1 mRNA suggested the osteogenic potential of the HPdLLT. The results indicated in vitro HPdLLT formation, and it could be used in future periodontal ligament tissue engineering to achieve optimal periodontal regeneration.

  65. Preparation of carboxylated Ag nanoparticles as a coating material for medical devices and control of antibacterial activity Peer-reviewed

    Furuzono, T., Iwamoto, T., Azuma, Y., Okada, M., Sawa, Y.

    Journal of Artificial Organs　16　(4)　451-457　2013/07/22

    Publisher: Springer

    DOI： 10.1007/s10047-013-0715-3 　

    ISSN： 1434-7229 1619-0904

  66. Hydroxyapatite-coated poly(-caprolactone) microspheres fabricated via a Pickering emulsion route: Effect of fabrication parameters on diameter and chemical composition Peer-reviewed

    Fujii, S., Okada, M., Nishimura, T., Sugimoto, T., Maeda, H., Hamasaki, H., Furuzono, T., Nakamura, Y.

    Composite Interfaces　20　(1)　45-56　2013/02/01

    Publisher: Taylor \& Francis

    DOI： 10.1080/15685543.2013.762893 　

    ISSN： 0927-6440 1568-5543

  67. A novel approach to prepare hydroxyapatite-coated biodegradable polymer microspheres loaded with magnetic Fe3O4 via nanoparticle-stabilized emulsions Peer-reviewed

    Okada, M., Takeda, S., Furuzono, T.

    Key Engineering Materials　529-530　(1)　223-228　2013

    Publisher: Key Engineering Materials

    DOI： 10.4028/www.scientific.net/KEM.529-530.223 　

    ISSN： 1662-9795 1013-9826

    eISSN： 1662-9795

  68. In vitro degradation of hydroxyapatite nanoparticle-coated biodegradable microspheres Peer-reviewed

    Fujii, S., Miyanari, Y., Nishimura, T., Yokoyama, Y., Hamasaki, S., Okada, M., Furuzono, T., Matsuda, S., Takamori, H., Nakamura, Y.

    Polymer Degradation and Stability　98　(1)　377-386　2013/01/01

    Publisher: Elsevier

    DOI： 10.1016/j.polymdegradstab.2012.09.003 　

    ISSN： 0141-3910

  69. Solvent-free formation of hydroxyapatite coated biodegradable particles via nanoparticle-stabilized emulsion route Peer-reviewed

    Okada, M., Fujii, S., Nishimura, T., Nakamura, Y., Takeda, S., Furuzono, T.

    Applied Surface Science　262　39-44　2012/12/01

    Publisher: Elsevier

    DOI： 10.1016/j.apsusc.2012.01.016 　

    ISSN： 0169-4332

  70. Development of microspheres covered with hydroxyapatite nanocrystals as cell scaffold for angiogenesis Peer-reviewed

    Iwamoto, T., Terada, T., Kogai, Y., Okada, M., Fujii, S., Furuzono, T.

    Functional Materials Letters　5　(2)　1260010-1260010　2012/06/02

    Publisher: World Scientific

    DOI： 10.1142/S1793604712600107 　

    ISSN： 1793-6047 1793-7213

  71. Formation of pickering emulsions stabilized via interaction between nanoparticles dispersed in aqueous phase and polymer end groups dissolved in oil phase Peer-reviewed

    Okada, M., Maeda, H., Fujii, S., Nakamura, Y., Furuzono, T.

    Langmuir　28　(25)　9405-9412　2012/05/22

    Publisher: ACS Publications

    DOI： 10.1021/la3015964 　

    ISSN： 0743-7463 1520-5827

  72. Hydroxyapatite-armored poly(ε-caprolactone) microspheres and hydroxyapatite microcapsules fabricated via a Pickering emulsion route Peer-reviewed

    Fujii, S., Okada, M., Nishimura, T., Maeda, H., Sugimoto, T., Hamasaki, H., Furuzono, T., Nakamura, Y.

    Journal of Colloid and Interface Science　374　(1)　1-8　2012/05/15

    Publisher: Elsevier

    DOI： 10.1016/j.jcis.2012.01.058 　

    ISSN： 0021-9797 1095-7103

  73. Enhancement of cell-based therapeutic angiogenesis using a novel type of injectable scaffolds of hydroxyapatite-polymer nanocomposite microspheres Peer-reviewed

    Mima, Y., Fukumoto, S., Koyama, H., Okada, M., Tanaka, S., Shoji, T., Emoto, M., Furuzono, T., Nishizawa, Y., Inaba, M.

    PLoS ONE　7　(4)　e35199　2012/04/18

    Publisher: Public Library of Science

    DOI： 10.1371/journal.pone.0035199 　

    ISSN： 1932-6203

  74. Hydroxylapatite nanoparticles: Fabrication methods and medical applications

    Okada, M., Furuzono, T.

    Science and Technology of Advanced Materials　13　(6)　064103-064103　2012

    Publisher: IOP Publishing

    DOI： 10.1088/1468-6996/13/6/064103 　

    ISSN： 1468-6996

  75. Hydroxyapatite/biodegradable poly(l-lactide-co - Caprolactone) composite microparticles as injectable scaffolds by a Pickering emulsion route

    Liu, X., Okada, M., Maeda, H., Fujii, S., Furuzono, T.

    Acta Biomaterialia　7　(2)　821-828　2011

    Publisher: Elsevier

    DOI： 10.1016/j.actbio.2010.08.023 　

    ISSN： 1742-7061

  76. Low-temperature synthesis of nanoparticle-assembled, transparent, and low-crystallized hydroxyapatite blocks

    Okada, M., Furuzono, T.

    Journal of Colloid and Interface Science　360　(2)　457-462　2011

    Publisher: Elsevier

    DOI： 10.1016/j.jcis.2011.04.068 　

    ISSN： 0021-9797 1095-7103

  77. Preparation and in vitro/in vivo evaluations of dimpled poly(L-lactic acid) fibers mixed/coated with hydroxyapatite nanocrystals

    Yanagida, H., Okada, M., Masuda, M., Narama, I., Nakano, S., Kitao, S., Takakuda, K., Furuzono, T.

    Journal of Artificial Organs　14　(4)　331-341　2011

    Publisher: Springer

    DOI： 10.1007/s10047-011-0594-4 　

    ISSN： 1434-7229 1619-0904

  78. In vivo evaluation of hydroxyapatite nanocoating on polyester artificial vascular grafts and possibility as soft-tissue compatible material

    Kadono, H., Furuzono, T., Masuda, M., Okada, M., Ueki, M., Takamizawa, K., Tanaka, R., Miyatake, K., Koyama, Y., Takakuda, K.

    ASAIO Journal　56　(1)　2010

    DOI： 10.1097/MAT.0b013e3181c945ae 　

    ISSN： 1058-2916

  79. Pickering-type water-in-oil-in-water multiple emulsions toward multihollow nanocomposite microspheres

    Maeda, H., Okada, M., Fujii, S., Nakamura, Y., Furuzono, T.

    Langmuir　26　(17)　13727-13731　2010

    Publisher: ACS Publications

    DOI： 10.1021/la102529d 　

    ISSN： 0743-7463 1520-5827

  80. In vitro secretion of TNF-α from bone marrow mononuclear cells incubated on amino group modified TiO2 nano-composite under ultrasound irradiation

    Furuzono, T., Masuda, M., Nitta, N., Kaya, A., Yamane, T., Okada, M.

    Materials Science and Engineering: B　173　(1-3)　191-194　2010

    Publisher: Elsevier

    DOI： 10.1016/j.mseb.2009.12.014 　

    ISSN： 0921-5107

  81. Fundamental study on activation of aminated titanium dioxide composite by low-intensity focused ultrasound irradiation in anti-infective catheter system

    Nitta, Naotaka, Kaya, Akio, Yamane, Takashi, Hyodo, Koji, Okada, Masahiro, Furuzono, Tsutomu

    Japanese Journal of Applied Physics　49　(7S)　07HF24-07HF24-7　2010

    Publisher: IOP Publishing

    DOI： 10.1143/JJAP.49.07HF24 　

    ISSN： 0021-4922

    More details Close

    It has been reported that the hydroxyl (OH) radical is produced by irradiating ultrasound to titanium dioxide (TiO2). On the other hand, infection at the exit site of catheter retained in the body has become a serious problem. Therefore, we are developing a novel anti-infective catheter system in which the exit site of a catheter is covered with an aminated titanium dioxide (AmTiO2) composite, which consists of AmTiO2 nanoparticles immobilized on a substrate and exhibits cell adhesiveness, and the anti-infective effect (OH radical production) is induced by irradiating low-intensity focused ultrasound (LIFU) to the composite. In this study, the ability to activate TiO2 nanoparticles by ultrasound irradiation was verified in a preliminary experiment, and then the feasibilities that the AmTiO2 composite is activated and that the OH radical is produced by LIFU irradiation were verified by dye decomposition experiment and dihydroxybenzoic acid (DHBA) measurement. In addition, as a trigger for activating the AmTiO2 composite by LIFU irradiation and for producing the OH radical, the decrease in cavitation threshold was suggested.

  82. Hydroxyapatite nanocrystal coating on biodegradable microspheres

    Okada, M., Furuzono, T.

    Materials Science and Engineering: B　173　(1-3)　199-203　2010

    Publisher: Elsevier

    DOI： 10.1016/j.mseb.2009.12.009 　

    ISSN： 0921-5107

  83. Cell adhesion and tissue response to hydroxyapatite nanocrystal-coated poly (L-lactic acid) fabric

    Yanagida, Hiroshi, Okada, Masahiro, Masuda, Miwa, Ueki, Mitsuki, Narama, Isao, Kitao, Satoshi, Koyama, Yoshihisa, Furuzono, Tsutomu, Takakuda, Kazuo

    Journal of bioscience and bioengineering　108　(3)　235-243　2009

    Publisher: Elsevier

    ISSN： 1389-1723

    More details Close

    Cell adhesion and tissue response to poly (L-lactic acid) (PLLA) fabric coated with nanosized hydroxyapatite (HAp) crystals were studied. The HAp nanocrystals were prepared by the wet chemical process followed by calcination at 800℃ with an anti-sintering agent to prevent calcination-induced sintering. After the PLLA fabric was hydrolyzed with an alkaline aqueous solution, the HAp nanocrystals were coated via ionic interaction between the calcium ions on the HAp and the carboxyl groups on the alkali-treated PLLA. The PLLA surface uniformly coated with the HAp nanocrystals was observed by scanning electron microscope. The ionic interaction between the HAp and the PLLA was estimated by FT-IR. Improved cell adhesion to the HAp nanocrystal-coated surface was demonstrated by in vitro testing using a mouse fibroblast cell line L929. Furthermore, reduced inflammatory response to the HAp nanocrystal-coated PLLA fabric (as compared with a non-treated one) was confirmed by a subcutaneous implantation test with rats. Thus the HAp nanocrystal-coated PLLA developed has possible efficacy as an implant material in the fields of general and orthopedic surgery, and as a cell scaffold in tissue engineering.

  84. Hydroxyapatite nanoparticles as particulate emulsifier: fabrication of hydroxyapatite-coated biodegradable microspheres

    Fujii, Syuji, Okada, Masahiro, Sawa, Hidekatsu, Furuzono, Tsutomu, Nakamura, Yoshinobu

    Langmuir　25　(17)　9759-9766　2009

    Publisher: ACS Publications

  85. Interfacial interactions between calcined hydroxyapatite nanocrystals and substrates

    Okada, M., Furukawa, K., Serizawa, T., Yanagisawa, Y., Tanaka, H., Kawai, T., Furuzono, T.

    Langmuir　25　(11)　6300-6306　2009

    Publisher: ACS Publications

    DOI： 10.1021/la804274q 　

    ISSN： 0743-7463

  86. TEM observation of hydroxyapatite nanocrystals ionicallybonded onto the graftpolymer-modified PET substrate

    Nakamura, A., Shishido, A., Kishida, I., Okada, M., Furuzono, T., Yokogawa, Y.

    Journal of the Ceramic Society of Japan　116　(1349)　100-104　2008

    Publisher: The Ceramic Society of Japan

    DOI： 10.2109/jcersj2.116.100 　

    ISSN： 1348-6535 1882-0743

  87. Preparation of hydroxyapatite-nanocrystal-coated stainless steel, and its cell interaction

    Okada, M., Masuda, M., Tanaka, R., Miyatake, K., Kuroda, D., Furuzono, T.

    Journal of Biomedical Materials Research - Part A　86　(3)　589-596　2008

    Publisher: Wiley Online Library

    DOI： 10.1002/jbm.a.31668 　

    ISSN： 1549-3296 1552-4965

  88. Preparation of poly (vinyl alcohol)/DNA hydrogels via hydrogen bonds formed on ultra-high pressurization and controlled release of DNA from the hydrogels for gene delivery

    Kimura, Tsuyoshi, Iwai, Sayaka, Moritan, Toshiyuki, Nam, Kwangwoo, Mutsuo, Shingo, Yoshizawa, Hidekazu, Okada, Masahiro, Furuzono, Tsutomu, Fujisato, Tosihya, Kishida, Akio

    Journal of Artificial Organs　10　(2)　104-108　2007

    Publisher: Springer

    DOI： 10.1007/s10047-006-0367-7 　

    ISSN： 1434-7229

  89. Calcination of rod-like hydroxyapatite nanocrystals with an anti-sintering agent surrounding the crystals

    Okada, M., Furuzono, T.

    Journal of Nanoparticle Research　9　(5)　807-815　2007

    Publisher: Springer

    DOI： 10.1007/s11051-006-9126-1 　

    ISSN： 1388-0764

  90. Hydroxyapatite nanoparticles as stimulus-responsive particulate emulsifiers and building block for porous materials

    Fujii, S., Okada, M., Furuzono, T.

    Journal of Colloid and Interface Science　315　(1)　287-296　2007

    Publisher: Elsevier

    DOI： 10.1016/j.jcis.2007.06.071 　

    ISSN： 0021-9797

  91. Nano-sized ceramic particles of hydroxyapatite calcined with an anti-sintering agent

    Okada, M., Furuzono, T.

    Journal of Nanoscience and Nanotechnology　7　(3)　848-851　2007

    Publisher: American Scientific Publishers

    DOI： 10.1166/jnn.2007.505 　

    ISSN： 1533-4880

  92. Fabrication of high-dispersibility nanocrystals of calcined hydroxyapatite

    Okada, M., Furuzono, T.

    Journal of Materials Science　41　(18)　6134-6137　2006

    Publisher: Springer

    DOI： 10.1007/s10853-006-0444-6 　

    ISSN： 0022-2461 1573-4803

  93. Increase in cell adhesiveness on a poly(ethylene terephthalate) fabric by sintered hydroxyapatite nanocrystal coating in the development of an artificial blood vessel

    Furuzono, T., Masuda, M., Okada, M., Yasuda, S., Kadono, H., Tanaka, R., Miyatake, K.

    ASAIO Journal　52　(3)　315-320　2006

    Publisher: LWW

    DOI： 10.1097/01.mat.0000214860.08820.f9 　

    ISSN： 1058-2916

  94. Optimization of amino group density on surfaces of titanium dioxide nanoparticles covalently bonded to a silicone substrate for antibacterial and cell adhesion activities

    Okada, Masahiro, Yasuda, Shoji, Kimura, Tsuyoshi, Iwasaki, Mitsunobu, Ito, Seishiro, Kishida, Akio, Furuzono, Tsutomu

    Journal of Biomedical Materials Research Part A　76　(1)　95-101　2006

    Publisher: Wiley Online Library

  95. Preparation of multihollow polymer particles by the alkali/cooling method under partial neutralization conditionsa)

    Masayoshi Okubo, Masahiro Okada, Kenjin Shiba

    Macromolecular Symposia　195　(1)　115-122　2003/07

    Publisher: Wiley

    DOI： 10.1002/masy.200390112 　

    ISSN： 1022-1360

    eISSN： 1521-3900

  96. Influence of nonionic emulsifier included inside carboxylated polymer particles on the formation of multihollow structure by the alkali/cooling method

    Okada, Masahiro, Matoba, Takumi, Okubo, Masayoshi

    Colloid and Polymer Science　282　(2)　193-197　2003

    Publisher: Springer

  97. Evaporation behavior of water from aqueous dispersions of multihollow particles prepared by the stepwise alkali/acid method Peer-reviewed

    M. Okubo, A. Sakauchi, M. Okada

    Colloid & Polymer Science　280　(1)　38-45　2002/01/01

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s003960200005 　

    ISSN： 0303-402X

    eISSN： 1435-1536

  98. Variation of the morphology of a carboxylated polymer film by alkali treatment

    Okubo, Masayoshi, Ito, Akira, Okada, Masahiro, Suzuki, Toyoko

    Colloid and Polymer Science　280　(6)　574-578　2002

    Publisher: Springer

  99. Heterogeneity among multihollow polymer particles prepared by the alkali/cooling method under partial neutralization conditions

    Okubo, Masayoshi, Okada, Masahiro, Shiba, Kenjin

    Colloid and Polymer Science　280　(9)　822-827　2002

    Publisher: Springer

  100. Formation mechanism of a multihollow structure within submicron-sized styrene/methacrylic acid copolymer particles by the stepwise acid/alkali method

    Okubo Masayoshi, Sakauchi Atsuko, Okada Masahiro

    Colloid and Polymer Science　280　(4)　303-309　2002

    Publisher: Springer

    DOI： 10.1007/s003960100551 　

    ISSN： 0303-402X

    eISSN： 1435-1536

  101. Production of micron-sized, monodisperse composite polymer particles having epoxy groups by seeded dispersion polymerization

    Okubo M, Okada M, Miya T, Takekoh R

    Colloid and Polymer Science　279　(8)　807-812　2001

    Publisher: Springer

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Misc. 28

  1. 生体軟組織用接着材としてのセラミックスおよび金属

    岡田正弘

    接着の技術誌　45　(1)　19-24　2025/06

  2. 生体材料の基礎知識（連載第3回）医療機器と再生医療

    岡田正弘

    手術看護エキスパート　18　(1)　79-86　2024/05

  3. 生体材料の基礎知識（連載第2回）生体材料の安全性

    岡田正弘

    手術看護エキスパート　17　(6)　66-74　2024/03

  4. 生体材料の基礎知識（連載第1回）生体材料って何？

    岡田正弘

    手術看護エキスパート　17　(5)　51-60　2024/01

  5. Inorganic solid-state adhesive for soft biological tissues Peer-reviewed

    Colloid & Interface Communications　48　(1)　20-22　2023/04/05

    DOI： 10.57534/cicommun.48.1_20 　

  6. Self-adhesive Devices Made of Titanium for Biological Soft Tissue Invited Peer-reviewed

    Masahiro Okada, Takuya Matsumoto

    Materia Japan　61　(11)　760-764　2022/11/01

    Publisher: Japan Institute of Metals

    DOI： 10.2320/materia.61.760 　

    ISSN： 1340-2625

    eISSN： 1884-5843

  7. 金属チタンをベースとした生体軟組織用の固体接着材 Invited

    岡田正弘, 松本卓也

    機能材料　40　(9)　50-56　2020/09

  8. 金属チタンが生体軟組織と瞬時に接着する！─既存の概念にない新しい生体組織接着材 Invited

    岡田正弘, 松本卓也

    化学　75　(8)　12-16　2020/08

  9. 軟組織用の生体親和性ナノ構造化固体接着材の開発 Invited

    岡田正弘, 松本卓也

    セラミックス-日本セラミックス協会誌　55　(3)　180-184　2020/03

  10. Hybrid Materials Coated with Hydroxyapatite Nanocrystals as Soft-tissue Compatible Bio-ceramics Invited

    FURUZONO Tsutomu, OKADA Masahiro

    Ceramics Japan　45　(8)　645-650　2010/08

    Publisher: 日本セラミックス協会

    ISSN： 0009-031X

  11. 微粒子安定化エマルションを利用する複合微粒子の創出

    藤井秀司, 岡田正弘, 古薗勉

    Cosmetic Stage　7　(4)　28-36　2010/04

  12. 新しい細胞移植療法のためのナノアパタイトコーティング微粒子材料

    岡田正弘, 福本真也, 三間洋平, 藤井秀司, 古薗勉

    バイオマテリアル—生体材料—　28　(2)　88-95　2010/02

  13. 臨床工学技士に薦める今月の一冊 Invited

    岡田正弘

    クリニカルエンジニアリング　20　(4)　373-373　2009/04

  14. ハイドロキシアパタイト・ナノ粒子を利用した医用材料の開発 Invited

    岡田正弘

    Colloid & Interface Communication　34　(4)　15-17　2009/04

  15. バイオマテリアルの夢を語る：夢と現実のバイオマテリアル Invited

    岡田正弘

    26　(3)　258-258　2008/03

  16. Nano-apatite monocrystal coating

    Function & materials　27　(11)　40-48　2007/11

    Publisher: シーエムシー出版

    ISSN： 0286-4835

  17. ナノアパタイト複合技術（ソフトナノセラミック・プロセッシング）とその応用

    岡田正弘, 古薗 勉

    マテリアル インテグレーション　20　(11)　113-119　2007/11

  18. カテーテル用材料の最新技術

    岡田正弘, 古薗 勉

    工業材料　55　(3)　32-35　2007/03

  19. An Organic-Nano Inorganic Hybrid Material as a Biomaterial for Medical Device

    FURUZONO Tsutomu, OKADA Masahiro

    Kobunshi　56　(3)　129-132　2007/03

    Publisher: The Society of Polymer Science, Japan

    DOI： 10.1295/kobunshi.56.129 　

    ISSN： 0454-1138

  20. 臨床工学技士のためのバイオマテリアル（連載第8回）：近未来に登場する先端バイオマテリアル

    岡田正弘, 古薗 勉

    クリニカルエンジニアリング　17　(11)　1250-1264　2006/11

  21. 臨床工学技士のためのバイオマテリアル（連載第7回）：再生医療におけるバイオマテリアルの位置付け

    岡田正弘, 古薗 勉

    クリニカルエンジニアリング　17　(9)　981-990　2006/09

  22. 臨床工学技士のためのバイオマテリアル（連載第6回）：金属系バイオマテリアルの基礎から医療応用まで

    岡田正弘, 古薗 勉

    クリニカルエンジニアリング　17　(7)　762-772　2006/07

  23. 臨床工学技士のためのバイオマテリアル（連載第5回）：セラミックス系バイオマテリアルの基礎から医療応用まで

    岡田正弘, 古薗 勉

    クリニカルエンジニアリング　17　(5)　517-523　2006/05

  24. 臨床工学技士のためのバイオマテリアル（連載第4回）：高分子系バイオマテリアルの基礎から医療応用まで

    岡田正弘, 古薗 勉

    クリニカルエンジニアリング　17　(3)　285-294　2006/03

  25. 臨床工学技士のためのバイオマテリアル（連載第3回）：バイオマテリアルに求められる生体適合性

    岡田正弘, 古薗 勉

    クリニカルエンジニアリング　17　(1)　75-81　2006/01

  26. 臨床工学技士のためのバイオマテリアル（連載第2回）：バイオマテリアルの安全性の確保とその評価法

    岡田正弘, 古薗 勉

    クリニカルエンジニアリング　16　(11)　1176-1183　2005/11

  27. 臨床工学技士のためのバイオマテリアル（連載第1回）：バイオマテリアルとしての条件と医療用デバイス

    岡田正弘, 古薗 勉

    クリニカルエンジニアリング　16　(9)　959-966　2005/09

  28. 生体接着性と抗菌性を発現する新規なカテーテル複合材料

    古薗 勉, 岡田正弘

    マテリアル インテグレーション　18　(6)　46-49　2005/06

    Publisher: ティ-・アイ・シ-

    ISSN： 1344-7858

Show all ︎Show first 5

Books and Other Publications 12

  1. ヴィジュアルでわかるバイオマテリアル 改訂第4版 (臨床工学ライブラリーシリーズ 5)

    古薗 勉, 岡田正弘

    Gakken　2023/03/02

    ISBN: 4055200404

  2. スタンダード歯科理工学: 生体材料と歯科材料 (第7版) (中嶌 裕, 宮崎 隆, 米山 隆之 編)

    松本卓也, 岡田正弘

    学建書院　2019/02/25

    ISBN: 4762456144

  3. ヴィジュアルでわかるバイオマテリアル 改訂第3版 (臨床工学ライブラリーシリーズ 5)

    古薗 勉, 岡田正弘

    学研メディカル秀潤社　2018/10/26

    ISBN: 4780909635

  4. Biomineralization–From Molecular and Nano-structural Analyses to Environmental Science (Endo K, Kogure T, Nagasawa H, Eds.)

    Okada M, Hara ES, Matsumoto T

    Springer　2018/10

  5. コアシェル微粒子の設計・合成技術・応用の展開 (川口春馬 監)

    藤井 秀司, 岡田正弘, 古薗 勉, 福本真也

    シーエムシー出版　2016/08

    ISBN: 9784781311173

  6. スタンダード歯科理工学 : 生体材料と歯科材料 (6版) (中嶌 裕, 西山 典宏, 宮崎 隆, 米山 隆之 編)

    松本卓也, 岡田正弘

    学建書院　2016/03

    ISBN: 9784762446146

  7. 再生医療技術の最前線 (岡野光夫, 大和雅之 監)

    古薗 勉, 小粥康充, 岡田正弘

    シーエムシー出版　2013/09

    ISBN: 9784781307336

  8. Biomimetics: Advancing Nanobiomaterials and Tissue Engineering (M. Ramalingam, X. Wang, G. Chen, P. Ma, F.-Z. Cui, Eds.)

    Syuji Fujii, Masahiro Okada, Tsutomu Furuzono

    2013/08/12

    ISBN: 1118469623

  9. 新版ヴィジュアルでわかるバイオマテリアル (臨床工学ライブラリーシリーズ 5)

    古薗勉, 岡田正弘

    学研メディカル秀潤社　2011/11/24

    ISBN: 4780908450

  10. BOTTOM-UP NANOFABRICATION: Supramolecules, Self-Assemblies, and Organized Films (K. Ariga and H.S. Nalwa, Eds.)

    T. Furuzono, S. Yasuda, M. Okada

    2009/01

  11. ヴィジュアルでわかるバイオマテリアル (臨床工学ライブラリーシリーズ 5)

    古薗 勉, 岡田 正弘

    学研メディカル秀潤社　2006/12/01

    ISBN: 4879623466

  12. ソフトナノテクノロジー ―バイオマテリアル革命― (田中 順三,下村 政嗣 監)

    岡田正弘, 古薗 勉

    シーエムシー出版　2005/07/01

    ISBN: 488231505X

Show all Show first 5

Presentations 196

  1. 生体軟組織との接着機能を有する固体接着材 Invited

    岡田正弘

    2025/03

  2. 薬剤放出能を付与したリン酸八カルシウム/生体吸収性合成高分子複合体の作

    木村 太, 濱井 瞭, 岡田正弘, 土屋香織, 山内健介, 鈴木 治

    日本セラミックス協会2025年年会　2025/03

  3. リン酸緩衝生理食塩水内で長期処理された脱細胞化骨の物性変化

    鄧 梓, 仲川 雅人, 松島 恭彦, 岡田 正弘, 本田 義知

    令和6年度日本歯科補綴学会関西支部学術大会　2024/12

  4. Protein adsorption and osteoblastic differentiation on octacalcium phosphate via different hydrolysis processes

    Ryo Hamai, Masahiro Okada, Kaori Tsuchiya, Osamu Suzuki

    The 22nd Asian BioCeramics Symposium (ABC2024)　2024/12

  5. 歯周組織への適用を目指した石灰化 dECM 膜の創製および評価

    鈴木美加, 木村剛, 橋本良秀, 岡田正弘, 松本卓也, 山田将博, 江草宏, 中村奈緒子, 岸田晶夫

    日本バイオマテリアル学会シンポジウム2024　2024/10

  6. 薬剤放出能を付与したリン酸八カルシウム/PLGA複合体による骨芽細胞分化

    木村 太, 濱井 瞭, 岡田正弘, 土屋香織, 山内健介, 鈴木 治

    日本バイオマテリアル学会シンポジウム2024　2024/10

  7. 脱灰条件が硬組織の有機質構造に与える影響

    謝世超, 岡田正弘, 松本卓也

    日本バイオマテリアル学会シンポジウム2024　2024/10

  8. 荷重部への応用を目指したOCP/PLGA複合体の検討

    林智洋, 濱井瞭, 叶内彩, 細谷敬三, 岡田正弘, 鈴木治

    日本バイオマテリアル学会シンポジウム2024　2024/10

  9. 無機材料と金属材料をベースとした軟組織用固体接着材の開発と応用 Invited

    岡田正弘

    日本バイオマテリアル学会シンポジウム2024　2024/10

  10. 蒸発晶析法によるエナメル質様組織形成の促進

    岡田正弘, 濱井暸, 鈴木治

    歯科理工学会 令和6（2024）年度北海道・東北地方会セミナー　2024/10

  11. 軟組織に対するアパタイト多孔質体の接着と脱着

    岡田正弘, 謝世超, 松本卓也

    日本セラミックス協会 第37回秋季シンポジウム　2024/09/10

  12. 軟組織と瞬間接着する固体接着材の開発と応用展開 Invited

    岡田正弘

    関西大学化学・物質工学分野大学院特別講演会　2024/08

  13. Solid-state adhesive of porous hydroxyapatite with on-demand attachment and detachment abilities

    2024/05

  14. The crack propagation of a mouse femur model with holes

    2024/05

  15. Cadmium ion removal by dissolution/precipitation of calcium phosphate

    2024/05

  16. レジンセメントのセラミックスに対するサーマルサイクル後の接着性と曲げ特性

    吉實 舞, 丸尾幸憲, 入江正郎, 長岡紀幸, 岡田正弘, 松本卓也

    第82回日本歯科理工学会学術講演会　2024/04

  17. 顎運動再現ロボットの開発

    大角京平, 上田恵吾, 佐藤嘉大, 松本卓也, 岡田正弘, 青柳陽之, 浮田浩行

    第82回日本歯科理工学会学術講演会　2024/04

  18. 骨基質モデルを想定した光架橋型リボフラビン-コラーゲンゲルの作製

    大高晋之, 岡田正弘, 松本卓也

    第82回日本歯科理工学会学術講演会　2024/04

  19. パッシブ赤外分光イメージングによる歯質情報の二次元可視化 -機械学習による発光スペクトルと硬さの相関 -

    岡田正弘, 山下創央, 大高晋之, 石丸伊知郎, 松本卓也

    第82回日本歯科理工学会学術講演会　2024/04

  20. On-demand detachable hydroxyapatite adhesive for biological soft tissues International-presentation

    Xie SC, Okada M, Kobayashi Y, Matsumoto T

    MRM2023/IUMRS-ICA2023　2023

  21. Fabrication of shape-controllable calcium phosphate/gelatin composite with brick-and-mortar architecture International-presentation Invited

    Okada M, Jiao YY, Matsumoto T

    MRM2023/IUMRS-ICA2023　2023

  22. Distinctive behavior of trabecular bone during growth and degeneration International-presentation

    Kamada A, Randa M, Sung P, Okada M, Matsumoto T

    The 71st Annual Meeting of Japanese Association for Dental Research　2023

  23. Time course evaluations of trabecular bone morphologyin femur epiphysis International-presentation

    Randa M, Sung P, Okada M, Matsumoto T

    The 71st Annual Meeting of Japanese Association for Dental Research　2023

  24. Trabecular bone morphologic changes during growth from material science perspective International-presentation

    Sung P, Randa M, Okada M, Matsumoto T

    The 71st Annual Meeting of Japanese Association for Dental Research　2023

  25. 酸処理チタンの抗菌性とその応用

    岡田正弘, 謝 世超, 松本卓也

    第45回日本バイオマテリアル学会大会　2023

  26. オンデマンドで脱着可能な軟組織用固体接着材の開発

    青柳陽之, 岡田正弘, 松本卓也

    第45回日本バイオマテリアル学会大会　2023

  27. Investigation of organic molecules binding mechanism by using apatite plate model

    Jiao YY, Okada M, Matsumoto T

    令和5年度日本歯科理工学会近畿・中四国地方会セミナー　2023

  28. Effect of particle size of various inorganic milled particles on protein adsorption International-presentation

    Bikharudin A, Okada M, Matsumoto T

    Biomaterials International 2023　2023

  29. Effect of porous structure of hydroxyapatite on immediate adhesion onto biological soft tissues International-presentation

    Okada M, Xie SC, Matsumoto T

    Biomaterials International 2023　2023

  30. 無機微粒子の合成の基礎 Invited

    岡田正弘

    2023年度 関西支部 基礎セミナー　2023

  31. Investigation of calcospherites fusion by using apatite plate model International-presentation

    Jiao YY, Fang C, Hara ES, Okada M, Matsumoto T

    2023 SFB Annual Meeting & Exposition　2023

  32. 軟組織接着性アパタイトを二次元アレイ状に配置した新規接着器材の開発

    謝 世超,岡田正弘,松本卓也

    第80回日本歯科理工学会学術講演会　2023

  33. 歯科用ジルコニアに対する簡便な表面滑沢・防汚コーティング

    岡田正弘,藤井惠朗,松本卓也

    第80回日本歯科理工学会学術講演会　2023

  34. 歯根膜応用を目指した石灰化 dECM 膜の in vivo 骨結合性評価

    鈴木美加,木村 剛,岡田正弘,松本卓也,山田将博,江草 宏,中村奈緒子,岸田晶夫

    第80回日本歯科理工学会学術講演会　2023

  35. 象牙質石灰化における細胞膜由来リン脂質の局在と役割

    穴田理嵯,ハラ エミリオ サトシ,長岡紀幸,岡田正弘,松本卓也

    第80回日本歯科理工学会学術講演会　2023

  36. 軟組織に瞬間接着するチタン製固体接着材の開発と応用展開 Invited

    岡田正弘

    第４回OUSフロンティアセミナー　2023

  37. 歯根膜応用を目指した骨親和性を有する dECM 膜の調製

    鈴木美加,木村剛,橋本良秀,岡田正弘,松本卓也,高橋宏信,清水達也,山田将博,江草宏,中村奈緒子,岸田晶夫

    第44回日本バイオマテリアル学会大会　2022

  38. アパタイトの軟組織接着性に及ぼす含水率の影響

    岡田正弘,謝 世超,松本卓也

    第44回日本バイオマテリアル学会大会　2022

  39. Effect of Particle Size of Various Inorganics on Protein Adsorption

    Bikharudin A, Okada M, Matsumoto T

    第44回日本バイオマテリアル学会大会　2022

  40. 細胞膜断片の石灰化機序の理解と骨組織修復への応用

    Hara ES,穴田理嵯,岡田正弘,松本卓也

    第44回日本バイオマテリアル学会大会　2022

  41. 表面処理剤と接着性レジンセメントの併用による歯質接着性向上

    矢部 淳,入江正郎, 岡田正弘,武田宏明, 鳥井康弘, 松本卓也

    第157回日本歯科保存学会2022年秋季学術大会　2022

  42. 二ケイ酸リチウムガラスのフッ化水素酸水溶液処理が接着強さへ及ぼす影響

    入江正郎, 岡田正弘, 矢部 淳,武田宏明, 松本卓也

    第157回日本歯科保存学会2022年秋季学術大会　2022

  43. Immediate soft tissue adhesion and mechanical property of acid-treated titanium wire mesh International-presentation

    Okada M, Xie SC, Matsumoto T

    International Dental Materials Congress 2022 (IDMC2022)　2022

  44. Fish bone inspired design of lamellar-structured calcium phosphate/gelatin composite by slip cast method International-presentation

    JIAO YY, OKADA M, and MATSUMOTO T

    International Dental Materials Congress 2022 (IDMC2022)　2022

  45. Surface characteristics of Ti-6Al-4V adhesive International-presentation

    Wang Y, Xie SC,Okada M,Matsumoto T

    International Dental Materials Congress 2022 (IDMC2022)　2022

  46. Identification and evaluation of initial dentin mineralization from material science perspective International-presentation

    Anada R, Hara ES,Nagaoka N, Okada M, Kamioka H,Matumoto T

    International Dental Materials Congress 2022 (IDMC2022)　2022

  47. Analysis of mineralization mechanisms of plasma membrane nanofragments for rapid in vitro bone tissue engineering International-presentation

    Hara ES, Okada M, Matsumoto T

    International Dental Materials Congress 2022 (IDMC2022)　2022

  48. 被着面の各種汚染に対する 象牙質レジンコーティング法の効果

    矢部 淳,入江正郎, 岡田正弘,武田宏明, 鳥井康弘, 松本卓也

    第156回日本歯科保存学会2022年春季学術大会　2022

  49. 歯科用セラミックスに対するレジンセメントの接着強さ: Dual-cureとSelf-cureの比較

    入江正郎, 岡田正弘,武田宏明, 松本卓也

    第156回日本歯科保存学会2022年春季学術大会　2022

  50. 周囲硬さ環境に起因する発生時メッケル軟骨のメカノトランスダクション

    穴田理嵯,Hara ES,Farahat M, 上岡 寛, 松本卓也

    第42回日本骨形態計測学会　2022

  51. Immediate soft tissue adhesion of hydroxyapatite: effect of surface microstructure International-presentation

    Xie SC, Okada M, Wang A, Matsumoto T

    The 100th General Session of the IADR/APR　2022

  52. Mechanotransductive mechanisms of microenvironmental stiffness-induced Meckel’s cartilage degeneration International-presentation

    Anada R, Farahat M, Hara ES, Kamioka H, Matsumoto T

    The 100th General Session of the IADR/APR　2022

  53. Shear bond strength to tooth structure of a new light-cured resin cement International-presentation

    Irie M, Maruo Y, Nishigawa G, Matsumoto T

    第41回日本接着歯学会学術大会／国際接着歯学会《併催》　2022

  54. ３次元生体模倣ゲル培養システムを用いたメッケル軟骨周囲硬さ環境の再現とその影響

    穴田理嵯,Hara ES,松本卓也

    第79回日本歯科理工学会学術講演会　2022

  55. 歯根膜としての応用を目指した片面石灰化 dECM 膜の調製

    鈴木美加,木村 剛,岡田正弘,中村奈緒子,岸田晶夫

    第79回日本歯科理工学会学術講演会　2022

  56. 酸処理チタンメッシュの軟組織接着性に与えるメッシュ径の影響

    岡田正弘,謝 世超,松本卓也

    第79回日本歯科理工学会学術講演会　2022

  57. 初期骨髄形成過程における海綿骨微細構造の経時的評価

    Hara ES,穴田理嵯,岡田正弘,松本卓也

    第79回日本歯科理工学会学術講演会　2022

  58. Rapid bone regeneration using biomimetic cellular membrane biocomposite International-presentation

    Hara ES, Okada M, Matsumoto T

    2022 Joint Symposium SFB+JSB　2022

  59. Re-evaluation of Early Biomolecule Adsorption and Initial Osseointegration by an Engineering Perspective International-presentation

    Wang Y, Okada M, Hara ES, Matsumoto T

    2022 Joint Symposium SFB+JSB　2022

  60. Immediate soft-tissue adhesive titanium: The effect of surface porosity International-presentation

    Okada M, Yabe A, Xie SC, Hara ES, Matsumoto T

    2022 Joint Symposium SFB+JSB　2022

  61. Natural Bamboo Leaf as an Immediate Soft Tissue Adhesive International-presentation

    Wang Y, Okada M, Osaka A, Xie S, Matsumoto T

    Material Research Meeting2021　2021

  62. Study on adsorption / desorption characteristics of bioorganic components and hydroxyapatite International-presentation

    焦 宇陽, 岡田正弘, 松本卓也

    Material Research Meeting2021　2021

  63. 軟組織接着向上に向けた粘膜組織水和相の理解 International-presentation

    小林優右, 岡田正弘, ハラエミリオサトシ, 田中 賢, 松本卓也

    第43回日本バイオマテリアル学会大会＆第8回アジアバイオマテリアル学会　2021

  64. マウス第一大臼歯の初期石灰化部位の特定と石灰化過程の材料学的評価 International-presentation

    穴田理嵯, Hara ES, 長岡紀幸, 岡田正弘, 上岡 寛, 松本卓也

    第43回日本バイオマテリアル学会大会＆第8回アジアバイオマテリアル学会　2021

  65. Initial bone apatite clusters in early endochondral and membranous ossification show different morphologies International-presentation

    Hara ES, Okada M, Nakano T, Matsumoto T

    第43回日本バイオマテリアル学会大会＆第8回アジアバイオマテリアル学会　2021

  66. 初期骨髄形成部位における海綿骨の定量・定性解析 International-presentation

    Hara ES, Okada M, Matsumoto T

    第43回日本バイオマテリアル学会大会＆第8回アジアバイオマテリアル学会　2021

  67. 界面から学ぶセラミックス系バイオマテリアル International-presentation

    岡田正弘

    第43回日本バイオマテリアル学会大会＆第8回アジアバイオマテリアル学会　2021

  68. ハイドロキシアパタイトの多孔質構造が軟組織接着性に与える影響 International-presentation

    謝世超, 岡田正弘, 王亜明, 松本卓也

    第43回日本バイオマテリアル学会大会＆第8回アジアバイオマテリアル学会　2021

  69. 新規光重合型レジンセメントの歯質接着性の検討

    入江正郎, 岡田正弘, 武田宏明, 鳥井康弘, 松本卓也

    日本歯科保存学会2021年度秋季学術大会(第155回）　2021

  70. レジンセメントの最近の歯科用セラミックスに対する接着強さの長期耐久性

    矢部淳, 入江正郎, 岡田正弘, 武田宏明, 鳥井康弘, 松本卓也

    日本歯科保存学会2021年度秋季学術大会(第155回）　2021

  71. Bone apatite-clusters in intramembranous and endochondral ossification show distinct morphologies

    Hara ES, Okada M, Matsumoto T

    第69回JADR総会・学術大会　2021

  72. A Materials Science-based Re-evaluation of Initial Tooth Mineralization

    Anada R, Hara ES, Nagaoka N, Okada M, Kamioka H, Matsumoto T

    第69回JADR総会・学術大会　2021

  73. 酸処理チタンの軟組織接着性を増強するサンドブラスト処理の最適化 International-presentation

    矢部淳, 岡田正弘, 武田宏明, ハラ・エミリオ・サトシ, 鳥井康弘, 松本卓也

    第78回日本歯科理工学会学術講演会　2021

  74. 人工歯周組織ユニット創製のためのアパタイトコーティング法の開発

    岡田正弘, 木村剛, 中村奈緒子, 岸田晶夫, 松本卓也

    第78回日本歯科理工学会学術講演会　2021

  75. 酸処理チタンの軟組織接着性を増強するサンドブラスト処理の最適化

    矢部淳, 岡田正弘, 武田宏明, Hara ES, 鳥井康弘, 松本卓也

    第78回日本歯科理工学会学術講演会　2021

  76. Early-stage interaction of water, biomolecules and cells on titanium implant surfaces

    Wang Y, Okada M, Hara ES, Matsumoto T

    第78回日本歯科理工学会学術講演会　2021

  77. 脱細胞化顎骨を利用したインプラント治療のための表面処理法の検討

    岡田正弘, 中村奈緒子, 松本卓也, 岸田晶夫, 木村剛

    第29回硬組織再生生物学会学術大会　2021

  78. Observation of minute-time interaction between biomolecular solution and material surface

    Wang Y, Takahashi A, Okada M, Kobayashi Y, Matsumoto T

    Brainstorming2021　2021

  79. Observation of minute-time interaction between biomolecular solution and material surface International-presentation

    Takahashi A, Okada M, Kobayashi Y, Wang Y, Matsumoto T

    The 99th General Session of the IADR　2021

  80. 2 ステップボンディング材の初期接着強さの経時的変化

    矢部淳, 入江正郎, 岡田正弘, 武田宏明, 鳥井康弘, 松本卓也

    日本歯科保存学会2021年度春季学術大会(第154回)　2021

  81. レジンセメントの最近の歯科用セラミックスに対する接着強さの長期耐久性

    入江正郎, 岡田正弘, 武田宏明, 鳥井康弘, 松本卓也

    日本歯科保存学会2021年度春季学術大会(第154回)　2021

  82. Biomimetic approaches for rapid bone-like tissue synthesis International-presentation

    Hara ES, Okada M, Matsumoto T

    1st NRF-JSPS Joint Symposium on advanced biomaterials for tissue engineering　2021

  83. 高透光性ジルコニアの単斜晶ナノジルコニア/シリカ処理による物性改善

    岡田正弘, 松本卓也

    第 77 回日本歯科理工学会学術講演会　2021

  84. 歯の初期石灰化部位の同定と最初期石灰化の材料学的検討

    穴田理嵯, Hara ES, 長岡紀幸, 岡田正弘, 松本卓也

    第 77 回日本歯科理工学会学術講演会　2021

  85. サンドブラスト処理による酸処理チタンの軟組織接着性の増強

    矢部淳, 岡田正弘, 武田宏明, Hara ES, 鳥井康弘, 松本卓也

    第 77 回日本歯科理工学会学術講演会　2021

  86. Mechanical properties and morphological aspects of Carassius langsdorfii rib bone

    焦 宇陽, 岡田正弘, Emilio Satoshi Hara, 謝世超, 長岡紀幸, 中野貴由, 松本卓也

    第 76 回日本歯科理工学会学術講演会 日本歯科理工学会 近畿・中四国地方会 令和2年度冬期セミナー　2021

  87. 酸処理によるチタンメッシュへの軟組織接着性の付与

    謝世超, 岡田正弘, 王亜明, 松本卓也

    第 76 回日本歯科理工学会学術講演会 日本歯科理工学会 近畿・中四国地方会 令和2年度冬期セミナー　2021

  88. 生体軟組織やハイドロゲルに接着する医療用金属とセラミックス

    岡田正弘, 松本卓也

    第25回岡山リサーチパーク研究・展示発表会　2020

  89. 汚染除去材が接着性レジンセメントのせん断接着強さに及ぼす影響

    矢部 淳, 入江正郎, 岡田正弘, 野崎高犠, 武田宏明, 鳥井康弘, 松本卓也

    特定非営利活動法人日本歯科保存学会2020年秋季学術大会（第152回）　2020

  90. 新規ボンディング材の歯質接着性からの検討：湿潤 vs. 乾燥

    入江正郎, 岡田正弘, 武田宏明, 鳥井康弘, 松本卓也

    特定非営利活動法人日本歯科保存学会2020年秋季学術大会（第152回）　2020

  91. 新規レジンセメントの歯質接着性からの検討：各種処理材の影響

    入江正郎, 岡田正弘, 武田宏明, 鳥井康弘, 松本卓也

    特定非営利活動法人日本歯科保存学会2020年秋季学術大会（第152回）　2020

  92. Computational chemistry of phospholipid mineralization

    HARA ES, KUNIOSHI N, OKADA M, MATSUMOTO T

    第68回国際歯科研究学会日本部会総会(JADR)総会・学術大会　2020

  93. ヒト血漿汚染被着面に対する汚染除去材の効果：接着強さからの検討

    入江正郎, 岡田正弘, 武田宏明, 鳥井康弘, 松本卓也

    特定非営利活動法人日本歯科保存学会2020年春季学術大会（第151回）　2020

  94. 臼歯修復用手動練和型のグラスアイオノマーセメント:I級窩洞適合性と歯質接着強さ

    入江正郎, 丸尾幸憲, 西川悟郎, 皆木省吾, 松本卓也

    第75回日本歯科理工学会学術講演会　2020

  95. 骨質指標としての骨基質配向化制御におけるオステオカルシンの役割

    中野貴由, 小笹良輔, 岡田正弘, 松本卓也, 森石武史, 小守壽文

    第75回日本歯科理工学会学術講演会　2020

  96. 単斜晶ジルコニアとシリカを焼付した高透光性ジルコニアの機械的性質

    岡田正弘, 宇野聡一郎, 武田宏明, 鳥井康弘, 松本卓也

    第75回日本歯科理工学会学術講演会　2020

  97. 臼歯修復用手動練和型のグラスアイオノマーセメント：Ⅰ級窩洞適合性と歯質接着強さ

    入江正郎, 丸尾幸憲, 西川悟郎, 皆木省吾, 松本卓也

    令和２年度春期第75日本歯科理工学会学術講演会　2020

  98. 生体組織接着材としてのチタン応用

    岡田正弘

    第8回 日本バイオマテリアル学会 中四国ブロック シンポジウム　2020

  99. 軟組織接着システムの開発

    矢部淳, 岡田正弘, Hara ES, 鳥井康弘, 松本卓也

    第40回岡山歯学会総会・学術集会　2019

  100. 軟骨細胞断片の石灰化能の検討

    角谷宏一, Akhter NM, Hara ES, 岡田正弘, 佐々木朗, 松本卓也

    第40回岡山歯学会総会・学術集会　2019

  101. In vitro?bioinspired rapid bone tissue synthesis byartificial cell nanofragments International-presentation

    Akhter NM, Hara ES, 岡田正弘, 松本卓也

    The 4th International Symposium of Medical and Dental Education in Okayama　2019

  102. Fabrication of bone nanocomposite using cell-derived nanofragments International-presentation

    Hara ES, Okada M, Matsumoto T

    Opto X Nano2019　2019

  103. Solid-state Inorganic Adhesives for Biological Soft Tissues

    Okada M

    3rd International Workshop on BioEngineering in Okayama　2019

  104. チタン製軟組織接着材の開発

    岡田正弘, 矢部淳, Hara ES, 岡田慧, 松本卓也

    第41回日本バイオマテリアル学会　2019

  105. 細胞フラグメントを用いた三次元骨様組織の構築

    Akhter NM, Hara ES, Farahat M, 岡田正弘, 松本卓也

    第41回日本バイオマテリアル学会　2019

  106. Development of nano-bioceramic coating for novel artificial periodontal tissue units International-presentation

    Okada M, Matsumoto T, Kishida A, Kimura T

    The 4th International Symposium on Biomedical Engineering (ISBE2019)　2019

  107. PEEK 表面のハイドロキシアパタイト修飾

    木村剛,岡田正弘,中村奈緒子,松本卓也,岸田晶夫

    第74回日本歯科理工学会学術講演会　2019

  108. 酸エッチング処理によるチタンの有機質吸着性変化

    岡田慧,岡田正弘,松本卓也

    第74回日本歯科理工学会学術講演会　2019

  109. 単斜晶ナノジルコニア焼付による高透光性ジルコニアの機械的性質改善

    岡田正弘,藤井惠朗,大島直也,入江正郎,松本卓也

    第74回日本歯科理工学会学術講演会　2019

  110. 生体ミネラルでできた新しい生体接着用材料

    岡田正弘

    BIO tech 2018 第17回 バイオ・ライフサイエンス研究展（第15回アカデミック フォーラム）　2018

  111. 軟組織に接着するソリッド・ステート・アドヒーシブの開発 Invited

    岡田正弘

    第76回メディカルテクノおかやま・サロン　2019

  112. 単斜晶ナノジルコニア焼付による従来型ジルコニアの機械的性質改善

    岡田正弘, 武田宏明, 鳥井康弘, 松本卓也

    第73回日本歯科理工学会学術講演会　2019

  113. 酸エッチング処理がチタン表面性質に及ぼす影響

    岡田慧, 岡田正弘, 松本卓也

    第73回日本歯科理工学会学術講演会　2019

  114. In vivo 石灰化における pH の影響

    Hara ES, 岡田正弘, 松本卓也

    第73回日本歯科理工学会学術講演会　2019

  115. Analysis of cell nanofragment mineralization obtained by different fabrication methods

    Akhter MN, Hara ES, Okada M, Matsumoto T

    第73回日本歯科理工学会学術講演会　2019

  116. プロテオーム解析による生体初期石灰化関連因子の同定

    Hara ES, 岡田正弘, 松本卓也

    第18回日本再生医療学会総会　2018

  117. Hydration structure of apatite crystal and bone mineral

    Okada M

    2nd Workshop on BioEngineering in Okayama　2018

  118. Bioinspired manipulation of environmental pH to induce rapid in vitro bone-like mineralization

    Hara ES, Okada M, Matsumoto T

    第66回国際歯科研究学会日本部会総会・学術大会　2018

  119. マウス頭蓋骨初期石灰化機構を模倣した新規石灰化技術の開発

    国富陽介、HARA ES、岡田正弘、上岡 寛、松本卓也

    第40回日本バイオマテリアル学会大会　2018

  120. 過酸化水素処理によるチタン表面ナノ構造の制御

    Yaming Wang、岡田正弘、矢部 淳、Guangxin Wang、尾坂明義、松本卓也

    第40回日本バイオマテリアル学会大会　2018

  121. pH環境が細胞膜ナノフラグメントの石灰化に及ぼす影響

    Hara ES, Okada M, Matsumoto T

    第40回日本バイオマテリアル学会大会　2018

  122. ミネラル周囲の水和構造と硬組織形成への影響

    岡田正弘、HARA ES、田中 賢、松本卓也

    第40回日本バイオマテリアル学会大会　2018

  123. Hydration structure of apatite and its relation to bone mineral formation International-presentation

    Okada M, Hara ES, Tanaka M, Matsumoto T

    Bioceramics30　2018

  124. 新規表面処理法が高透光性ジルコニアの機械的性質および接着性に及ぼす影響

    武田宏明, 岡田正弘, 宇野聡一郎, 入江正郎, 鳥井康弘, 松本卓也

    第39回岡山歯学会総会・学術集会　2018

  125. 新しい時代の生体組織用接着材料

    岡田正弘, Yaming Wang, 岡田慧, 松本卓也

    第39回岡山歯学会総会・学術集会　2018

  126. 高透光性ジルコニアに対する機械的表面処理条件の検討

    岡田正弘, 藤井惠朗, 宇野聡一郎, 武田宏明, 鳥井康弘,松本卓也

    第 72 回日本歯科理工学会学術講演会　2018

  127. 水ガラス被膜の耐水性向上に関する検討

    藤井惠朗,岡田正弘,入江正郎,松本卓也

    第 72 回日本歯科理工学会学術講演会　2018

  128. Fabrication of sodium titanate nanorod array on Ti6Al4V alloy

    WANG Y, Okada M, Matsumoto T

    第 72 回日本歯科理工学会学術講演会　2018

  129. Optimization of methods for artificial cell nanofragment mineralization

    Nahid MN, Hara ES, Okada M, Matsumoto T

    第 72 回日本歯科理工学会学術講演会　2018

  130. In vitro synthesis of bone-like tissue using cell nanofragments International-presentation

    Nahid MN, Hara ES, Okada M, Matsumoto T

    Tissue Engineering and Regenerative Medicine International Society - World Congress　2018

  131. Comparison of mineralization ability of cell nanofragments from different cells International-presentation

    Hara ES, Okada M, Matsumoto T

    The 96th General Session of the?IADR　2018

  132. 高透光性ジルコニアの機械的強さに及ほ?す表面処理の影響

    大島直也, 岡田正弘, 宇野聡一郎, 武田宏明, 鳥井康弘, 松本卓也

    第 71 回日本歯科理工学会学術講演会　2018

  133. 赤外スペクトル分析によるアハ?タイト水和構造評価

    井村和希, 橋本典也 , 岡田正弘 , 吉川一志 , 山本一世

    第 71 回日本歯科理工学会学術講演会　2018

  134. ジルコニアの表面処理によるグラススポリアルケノエートセメントの接着強さの改善

    藤井惠朗, 岡田正弘, 入江正郎, 松本卓也

    第 71 回日本歯科理工学会学術講演会　2018

  135. Bioinspired mineralization based on cell membrane nanofragments.

    Hara ES, Okada M, Matsumoto T

    第 71 回日本歯科理工学会学術講演会　2018

  136. マウス頭蓋骨初期石灰化部の形成と成長に関する検討

    国富陽介,Hara ES,岡田正弘,羽根知良,上岡寛,松本卓也

    第17回日本再生医療学会総会　2018

  137. 脂質成分を用いたin vitroミネラル形成能の検討

    Hara ES, Okada M, Matsumoto T

    第17回日本再生医療学会総会　2018

  138. Interfacial analysis of inorganic materials and soft tissues International-presentation Invited

    Okada M

    2018 NRF-JSPS Research workshop　2018

  139. Nanostructured bioceramics for hydrogel adhesives International-presentation Invited

    Okada M

    International Workshop on Bioengineering in Okayama　2018

  140. Development of hydroxyapatite nanostructured solid adhesives for soft tissues International-presentation Invited

    Okada M.

    Bioceramics in Dentistry-Taiwan-Japan workshop　2017

  141. Fabrication of brush-like hydroxyapatite coated biodegradable polymer films for hydrogel adhesives International-presentation

    Okada M, Hara ES, Matsumoto T.

    17th Asian BioCeramics Symposium　2017

  142. Differential scanning calorimetry study of water on ion-substituted apatite International-presentation

    Okada M, Hara ES, Ogura K, Tanaka M, Matsumoto T.

    17th Asian BioCeramics Symposium　2017

  143. Influence of surface treatment conditions on flexural strength of zirconia-based ceramics International-presentation

    Okada M, Taketa H, Irie M, Matsumoto T.

    17th Asian BioCeramics Symposium　2017

  144. Analysis of initial bone mineralization in different ossification modes International-presentation Invited

    Matsumoto T, Hara ES.

    17th Asian BioCeramics Symposium　2017

  145. 置換イオン含有量の異なるアパタイトの水和構造の評価

    岡田正弘, 小椋景子, 田中賢, 松本卓也.

    第39回日本バイオマテリアル学会大会　2017

  146. 生体内初期石灰化過程を模倣したミネラル形成に関する考察

    Hara ES, 長岡紀幸, 岡田正弘, 松本卓也.

    第39回日本バイオマテリアル学会大会　2017

  147. Secondary ossification as a model for designing new mineral formation methods mimicking bone formation in vivo

    Hara ES, Okada M, Matsumoto T.

    第65回国際歯科研究学会日本部会総会・学術大会　2017

  148. 歯科用ジルコニアへのサンドブラスト処理の影響

    岡田正弘, 武田宏明, 鳥井康弘, 入江正郎, 松本卓也.

    第 70 回日本歯科理工学会学術講演会プログラム　2017

  149. 歯科用ジルコニアと従来型グラスポリアルケノエートセメントの接着強さ

    藤井惠朗, 岡田正弘, 入江正郎, 松本卓也.

    第 70 回日本歯科理工学会学術講演会プログラム　2017

  150. 骨形成様式による骨アパタイト形成の違いに関する検討

    Hara ES, 岡田正弘, 長岡紀幸, 松本卓也.

    第 70 回日本歯科理工学会学術講演会プログラム　2017

  151. Fabrication of hydroxyapatite nanofibers with high aspect ratio via low-temperature wet precipitation methods under acidic conditions International-presentation

    Okada M, Matsumoto T.

    14th International Symposium on Biomineralization　2017

  152. Chondrocyte membrane fragment-based mineralization in the early stages of secondary ossification International-presentation

    Hara ES, Okada M, Matsumoto T.

    14th International Symposium on Biomineralization　2017

  153. ジルコニアに対する従来型グラスアイオノマーセメントの接着性改善

    藤井惠朗,岡田正弘,入江正郎,松本卓也.

    第38回岡山歯学会総会・学術集会　2017

  154. 骨形成様式による初期ミネラル形成の比較解析

    Hara ES, 国富陽介,長岡紀幸,岡田正弘, 上岡寛,松本卓也.

    第38回岡山歯学会総会・学術集会　2017

  155. 発生過程における骨形成様式の組織学的・材料学的比較定量解析

    Hara ES, Kunitomi Y, Okada M, Matsumoto T.

    日本歯科理工学会 近畿・中四国支部地方会セミナー　2017

  156. External stimulation-induced chondrocyte burst to accelerate endochondral ossification

    Iida LM, Hara ES, 岡田正弘, 松本卓也.

    第37回日本骨形態計測学会　2017

  157. 異なるイオンを置換したアハ?タイトの水和状態に関する検討

    小林大介, 甲斐翔己, 岡田正弘, 松本卓也.

    日本歯科理工学会第69回春期学術講演会　2017

  158. Characterization of the first minerals formed during endochondral ossification

    松本卓也, Hara ES, 岡田正弘.

    日本歯科理工学会第69回春期学術講演会　2017

  159. シ?ルコニアの曲け?強さに与える表面処理の影響

    岡田正弘, 武田宏明, 鳥井康弘, 松本卓也.

    日本歯科理工学会第69回春期学術講演会　2017

  160. Identification of the first minerals formed during endochondral ossification

    Hara ES, Okada M, Nagaoka N, Kuboki T, Matsumoto T.

    日本歯科理工学会第69回春期学術講演会　2017

  161. Qualitative/quantitative analysis of apatite crystals during cartilage-to-bone-to-bone marrow transition International-presentation

    Hara ES, Okada M, Nagaoka N, Takako H, Kuboki T, Matsumoto T.

    95th General Session & Exhibition of the IADR　2017

  162. 生体無機結晶再生に向けたin vitro環境場の構築

    竿尾歩、Hara ES, 岡田 正弘, 松本 卓也.

    第16回日本再生医療学会総会　2017

  163. 生物学・材料学の複合的アプローチによる頭蓋骨初期石灰化機構の理解

    国富陽介, Hara ES, Okada M, Matsumoto T.

    第16回日本再生医療学会総会　2017

  164. マウス頭蓋骨石灰化開始点の同定及び無機質の定性・定量解析

    国富陽介, Hara ES, 岡田正弘, 上岡寛, 松本卓也.

    第5回日本バイオマテリアル学会中四国ブロックシンポジウム　2017

  165. メッケル軟骨吸収過程の時間空間的検討

    宇野聡一郎, Hara ES, Gulsan AS, Mahmoud F, 岡田正弘, 松本卓也.

    第5回日本バイオマテリアル学会中四国ブロックシンポジウム　2017

  166. Chondrocyte burst promotes space for mineral expansion during initial endochondral ossification International-presentation

    Hara ES, Okada M, Takako H, Kuboki T, Nakano T, Matsumoto T

    94th General Session & Exhibition of the IADR　2016

  167. Biocompatible nanostructured solid adhesives for soft tissues International-presentation

    Okada M, Nakai A, Matsumoto T

    94th General Session & Exhibition of the IADR　2016

  168. 結晶構造を制御したジルコニア系ナノファイバーの合成と応用

    岡田正弘,武田宏明 ,松本卓也

    日本歯科理工学会第67回春期学術講演会　2016

  169. 分散性に優れるジルコニア系ナノ粒子の合成と応用

    岡田正弘,武田宏明 ,松本卓也

    日本歯科理工学会第67回春期学術講演会　2016

  170. シランカップリング剤プライマーを用いたジルコニアとレジンセメントとの接着力に関する研究

    井上倭総,入江正郎,岡田正弘, 松本卓也

    日本歯科理工学会第67回春期学術講演会　2016

  171. ナノバイオセラミックスの応用展開 Invited

    岡田正弘

    ものづくりバトンゾーン形成研究会 ナノバイオ応用技術WG　2016

  172. ハイドロキシアパタイトを用いた生体組織用接着剤の開発

    中井 暉,岡田 正弘,松本 卓也

    第4回日本バイオマテリアル学会中四国シンポジウム　2016

  173. 高靱性材料の開発に向けたジルコニアのナノ形態および結晶相制御

    岡田 正弘,武田 宏明,松本 卓也

    第4回日本バイオマテリアル学会中四国シンポジウム　2016

  174. Chondrocyte burst is necessary for mineral expansion during initial endochondral ossification

    原 エミリオ,岡田 正弘,松本 卓也

    第4回日本バイオマテリアル学会中四国シンポジウム　2016

  175. アパタイトナノファイバーの化学沈殿法による合成

    岡田正弘,ハラ エミリオ サトシ,松本卓也

    第37回日本バイオマテリアル学会大会　2015

  176. 硬組織石灰化を生命科学、材料学の双方向から検討する

    ハラ エミリオ サトシ, 岡田正弘, 松本卓也

    第36回岡山歯学会総会・学術集会　2015

  177. 光触媒抗菌性を付与した矯正装置の開発

    岡田正弘, 粟田麻祐子, 松本尚之, 松本卓也

    第36回岡山歯学会総会・学術集会　2015

  178. 生物から学ぶ有機無機ハイブリッド材料の作り方

    岡田正弘, Emilio Hara, 松本卓也

    第64回高分子討論会　2015

  179. Stem Cell Hoi-Hoi

    Hara ES, Okada M, Matsumoto T.

    バイオアセンブラ第4回若手シンポジウム　2015

  180. 高アスペクト比アパタイトナノファイバーの簡便な湿式合成

    岡田正弘, Rahman Kazi Anisur, 河田真宏, 松本卓也

    日本歯科理工学会第65回春期学術講演会　2015

  181. Qualitative analysis of tissue mineralization during secondary ossification of mouse femur

    Emilio Satoshi Hara, Masahiro Okada, Takako Hattori, Satoshi Kubota, Takuo Kuboki, Takuya Matsumoto

    The 36th Annual Meeting of the Japanese Society for Biomaterials　2014

  182. ナノポーラスアパタイトの孔径によるタンパク質放出挙動の制御

    岡田正弘, 橋本典也, 馬場俊輔, 至田宗泰, 松本卓也

    日本バイオマテリアル学会　2014

  183. ナノポーラスアパタイトを用いた低分子量タンパク質ナノトラップの開発

    岡田正弘, 松本卓也

    日本バイオマテリアル学会　2014

  184. Fabrication of 3 dimensional device for preparing the hydrogel beads.

    Sathi Gulsan Ara, Rahman Kazi Anisur, 武田宏明, Farahat Ibrahim, 岡田正弘, 鳥井康弘, 松本卓也

    The 36th Annual Meeting of the Japanese Society for Biomaterials　2014

  185. マウス大腿骨の二次骨化中の組織石灰化に関する定性分析(Qualitative analysis of tissue mineralization during secondary ossification of mouse femur)

    ハラ・エミリオ・サトシ, 岡田 正弘, 服部 高子, 久保田 聡, 窪木 拓男, 松本 卓也

    日本バイオマテリアル学会大会予稿集　2014/11

  186. リン酸カルシウムナノ集合体の合成と応用

    岡田正弘、松本卓也

    第35回 岡山歯学会総会ならひ?に学術集会　2014

  187. Novel Insights into the Mineralization Process during Secondary Ossification of the Cartilage International-presentation

    Hara ES, Okada M, Hattori T, Kubota S, Kuboki T, Matsumoto T.

    International Symposium 2014 - Foresight Program on Nano-Biomaterials and Regenerative Medicine　2014

  188. Quantitative analysis of mineralized tissue formation during cartilage secondary ossification of mouse femur International-presentation

    Hara ES, Okada M, Matsumoto T.

    International Symposium 2014 - Foresight Program on Nano-Biomaterials and Regenerative Medicine　2014

  189. 荷重下における三次元In Vitroヒト歯根膜様組織の細胞生存と遺伝子発現

    廖文, 岡田正弘, 居波薫, 橋本典也, 松本尚之

    第544回大阪歯科学会例会　2014

  190. カルシウム欠損型アパタイトナノ粒子集合体を利用した二相性リン酸カルシウムナノ多孔質体の組成制御

    岡田正弘, 上平真代, 藤原敬子, 松本尚之, 武田昭二

    日本セラミックス協会2014年年会　2014

  191. ナノサイズで分散可能なハイドロキシアパタイト結晶の開発

    岡田正弘, 大森裕子, 松本尚之, 武田昭二

    日本動物実験代替法学会第26回大会　2013

  192. 細胞の直接観察が可能な低結晶性アハ?タイト透明体の作製と評価

    上平真代, 藤原敬子, 松本尚之, 武田昭二, 岡田正弘

    日本動物実験代替法学会第26回大会　2013

  193. Novel route for the synthesis of nanostructured hydroxyapatite crystals International-presentation

    Okada M, Omori Y, Matsumoto N and Takeda S

    6th International Symposium on Nanotechnology, Occupational and Environmental Health　2013

  194. ナノ多孔質構造をもつリン酸カルシウムの組成制御

    岡田正弘, 上平真代, 藤原敬子, 松本尚之, 武田昭二

    第62回日本歯科理工学会学術講演会　2013

  195. ナノサイズのバイオセラミックスの開発とコーティングによるハイブリッド化 Invited

    岡田正弘

    ナノ・ハ?イオメテ?ィカル学会主催シンホ?シ?ウム：In vitro 評価における動物実験代替　2013

  196. バイオマテリアルとしての微粒子材料

    岡田正弘

    第13回 次世代医工学研究会　2013

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Industrial Property Rights 18

  1. 生体組織接着剤の製造方法及び生体組織接着剤

    松本 卓也, 岡田 正弘

    特許6842170

    Property Type: Patent

  2. 歯科用修復キット、補綴物の使用方法、補綴物及び補綴物の製造方法

    岡田正弘, 松本卓也, 有田明史

    特許6817975

    Property Type: Patent

  3. 医療用組成物および医療用キット

    福本真也, 小山英則, 西沢良記, 古薗勉, 岡田正弘

    特許5725489

    Property Type: Patent

  4. 複合粒子の製造方法

    古薗 勉, 岡田 正弘, 藤井 秀司, 松田 晶二郎, 小粥 康充

    特許5665332

    Property Type: Patent

  5. 非球形微粒子および非球形微粒子の製造方法

    古薗 勉, 岡田正弘, 松田晶二郎, 小粥康充

    特許5463504

    Property Type: Patent

  6. リン酸カルシウム透明体およびその製造方法

    古薗 勉, 岡田 正弘, 安田 昌司, 小粥 康充

    特許5299658

    Property Type: Patent

  7. 細胞分散方法

    古薗 勉, 岡田 正弘, 山原 研一

    特許5284031

    Property Type: Patent

  8. 分散体、分散体の製造方法、リン酸カルシウム中空粒子の製造方法、リン酸カルシウム多孔質体の製造方法、リン酸カルシウム複合微粒子の製造方法、及びそれらの利用

    古薗 勉, 藤井 秀司, 岡田 正弘, 安田 昌司, 小粥 康充

    特許5257646

    Property Type: Patent

  9. 超音波医療装置

    古薗 勉, 益田 美和, 岡田 正弘, 新田 尚隆, 山根 隆志

    特許5229473

    Property Type: Patent

  10. セラミック粒子群およびその製造方法並びにその利用

    古薗 勉, 岡田 正弘

    特許5043436

    Property Type: Patent

  11. 人工血管の製造方法

    古薗 勉, 宮武 邦夫, 田中 良一, 岡田 正弘, 安田 昌司, 角野 弘幸, 益田 美和

    特許5028625

    Property Type: Patent

  12. 官能基導入無機化合物および複合体の製造方法

    古薗 勉, 田中 順三, 岡田 正弘, 安田 昌司

    特許4649654

    Property Type: Patent

  13. 生体軟組織への接着材の接着方法、生体軟組織の変形補助方法、生体へのセンサの固定方法、生体軟組織用接着材、生体軟組織変形補助材、生体内埋入型センサ

    松本卓也, 岡田正弘

    Property Type: Patent

  14. チタン材料と生体軟組織との接着方法

    松本卓也, 岡田正弘

    Property Type: Patent

  15. ジルコニア強化剤、強化方法及び歯冠修復物

    工藤恭敬, 松本卓也, 岡田正弘

    Property Type: Patent

  16. 有床人工歯製造装置、有床人工歯製造システム及び有床人工歯の製造方法

    島文男, 松本卓也, 岡田正弘, 三輪昌史, 浮田浩行, 柳下勇, 遠宮史一

    Property Type: Patent

  17. 有床人工歯のデータ生成装置

    島文男, 松本卓也, 岡田正弘

    Property Type: Patent

  18. 生体吸収性複合中空粒子及びその製造方法

    古薗 勉, 岡田正弘, 小粥康充, 高森秀樹, 松田晶二郎

    Property Type: Patent

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Research Projects 20

  1. Investigation of metal-tissue adhesion and its application as self-adhering medical devices

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2024/04/01 - 2028/03/31

  2. 硬組織/歯科生体材料最表層の水和相理解と制御による界面超機能化

    松本 卓也, 松本 正和, 岡田 正弘

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 挑戦的研究(萌芽)

    Institution: 岡山大学

    2024/06 - 2027/03

  3. 細胞膜模倣バイオマテリアルの創製と迅速骨再生への応用

    松本 卓也, 江草 宏, ハラ エミリオ・サトシ, 岡田 正弘

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 岡山大学

    2022/04/01 - 2026/03/31

  4. Analysis and control of interface between soft tissue and hard adhesive

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Okayama University

    2021/04 - 2024/03

  5. Reproduction and control of the initial steps of bone marrow formation by using cell membrane nanofragments

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Okayama University

    2020/04 - 2024/03

  6. Development of a novel implantable device fixation method

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Research (Exploratory)

    Institution: Okayama University

    2021/07 - 2023/03

  7. Development of tissue adhesives with nanostructured biomaterials

    Okada Masahiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Okayama University

    2018/04 - 2021/03

    More details Close

    We found that nanoporous hydroxyapatite, a type of bioceramics, adhered to hydrogels and soft tissues under hydrous conditions. The purpose of this study was to understand and apply the above adhesion phenomenon. First, calcium phosphates having different compositions were synthesized, and their interactions with proteins and water molecules related to adhesion were evaluated. In addition, the adhesion strength with the hydrogel was quantitatively evaluated, and the effect of the morphology of apatite on the adhesiveness was evaluated. Furthermore, we conducted a study using metallic titanium and found that it also adheres to soft tissues under hydrous conditions.

  8. Mechano-chemical control of in vitro environment for bilogical tissue manipulation

    Matsumoto Takuya, Okada Masahiro, Hara Emilio

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Okayama University

    2016/04/01 - 2019/03/31

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    In this study, we aimed to develop a culture system that can be loaded with appropriate mechanical and chemical stimuli for growth control of three-dimensional cell mass. In salivary gland tissue, a system was established that could allow isolated salivary gland cells to be present as aggregates in matrigel to achieve three-dimensional self-assembly in vitro. As a result of using this constructed culture system, it was found that RGD, which is a functional motif of MCSF and fibronectin, promotes self-assembly. On the other hand, as a result of the understanding of the bone tissue formation process as hard tissue, it was clarified that the cell membrane fragment generated as a result of the rupture of hypertrophic chondrocytes becomes the nucleation origin of bone formation. Based on these results, we could construct a culture system to reproduce the new calcification process in vitro.

  9. Analysis of the initial mineralization in secondary ossification center by the Life Science and Material Science viewpoints

    Hara Emilio Satoshi, Matsumoto Takuya, Okada Masahiro, Kuboki Takuo, Nagaoka Noriyuki, Hattori Takako

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Research Activity Start-up

    Institution: Okayama University

    2016/08/26 - 2018/03/31

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    We investigated the initial stages of endochondral ossification during secondary ossification of mouse femur epiphysis from the Life Science and Material Science viewpoints. We found that the very initial starting point of mineral formation in the epiphysis occurs at post-natal day 6 (P6). Electron microscopy-based ultrastructural analysis showed that cell-secreted matrix vesicles were absent in the early steps of osteoblast-independent endochondral ossification. Instead, chondrocyte membrane fragments were found in the fibrous matrix surrounding the hypertrophic chondrocytes. EDS analysis and electron diffraction study indicated that cell membrane fragments acted as nuclei for newly formed calcospherites which initially showed an amorphous calcium phosphate phase, and then transformed into apatite crystal phase. These findings would be valuable to develop novel organic-inorganic hybrid materials for manipulation of biomineralization.

  10. Development of functional nano-particle based bioadhesive

    Masahiro Okada

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Okayama University

    2015/04 - 2018/03

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    In this study, we developed a novel biological tissue adhesive based on nanoapatite synthesized in various shapes as base materials. Here we showed their possibility for bioadhesives. Mechanical properties of this adhesion was carried out, and the mechanism from a histological point of view was also investigated. As a result, uptake of concentrated collagen fibers into the apatite pores was observed, and the possibility of water transfer as an adhesion mechanism was also suggested.

  11. Fabrication of superplastic bioceramics

    Masahiro Okada

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Okayama University

    2015/04 - 2017/03

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    In this study, we fabricated tetragonal zirconia nanofibers via crystal transformation of monoclinic zirconia nanofibers prepared by hydrothermal crystal growth method using zirconia nanoparticles as a seed and amorphous precursors as a reservoir. The crystal formation of zirconia from monoclinic to tetragonal could be achieved by calcination at 600°C in the presence of stabilizing ions such as Ca and Y. The tetragonal zirconia nanofibers fabricated here will be useful to fabricate superplastic ceramic biomaterials by using the stress-induced crystal phase transformation of tetragonal zirconia.

  12. High order functionalization using the low dimensional nano space of titania nanotubes and application to DDS

    Masahiro Okada

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Osaka Dental University

    2014/04 - 2017/03

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    Since one of the potential applications of titanium oxide nano-tubes (TNT) is to photodynamic therapy (PDT), the effects of reactive oxygen species (ROS) formed by TNT irradiated with ultraviolet (UV) rays were evaluated in HeLa cells. An oxidative stress fluorescence probe was then used to visualize oxidative stress in HeLa cells, and revealed that the ROS formed by TNT led to oxidative stress in HeLa cells. A flow cytometric analysis was performed to characterize the cell status and distinguish between viable and unviable cells. Polyethylene glycol (PEG) modifications to the surfaces of TNT effectively facilitated adherence to cells, and the UV irradiation of HeLa cells during their incubation in culture medium containing PEG-modified TNT induced oxidative stress, thereby suppressing DNA repair.

  13. Fabrication of growth factor-sustained release scaffold for treating root apical lesion of root incomplete teeth

    Masahiro Okada

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Osaka Dental University

    2013/04 - 2017/03

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    HAp nanoparticle-assembled powder was applied to exposed dental pulp of rat molars, and the tissue reaction was then examined histologically to assess its biocompatibility and ability to promote hard tissue formation. The pulps of maxillary first molars of male Wistar rats were exposed and then capped directly by using either basic fibroblast growth factors (bFGF)/HAp nanoparticle-assembled powders (experimental group) or only HAp nanoparticle-assembled powders . Histologic examinations showed that there were few inflammatory cells in the pulp near the exposed sites in both groups at 1 week. At 2 weeks, reparative dentin covered with a layer of odontoblast-like cells was observed in the experimental group. bFGF/HAp nanoparticle-assembled powder promoted healing of the dental pulp.

  14. 改良沈殿法による単分散ナノセラミックスの合成

    岡田正弘

    Offer Organization: 科学技術振興機構

    System: 研究成果展開事業マッチングプランナープログラム

    2015/01 - 2016/09

  15. Development of guided tissue regeneration membrane with the control of nanoscale surface structure

    Masahiro Okada

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Osaka Dental University

    2013/04 - 2016/03

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    Biodegradable polymer fibers having micron-sized diameters and nano-sized surface roughness could be successfully fabricated by an electrospinning method under high humidity conditions. In addition, highly-dispersible calcium phosphate nanoparticles could be successfully fabricated by a novel method based on a homogenous solid state reaction. The combination of α- tricalcium phosphate which is bioactive bioceramics and biodegradable polymer fibers exhibited excellent bone forming ability in a rat calvarial bone defect model.

  16. Fabrication and evaluation of low crystallinity and transparent hydroxyapatite via soft processing

    OKADA Masahiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Osaka Dental University

    2011 - 2013

    More details Close

    Hydroxyapatite (HAp) exhibits excellent cell adhesion because of favorable adsorption capacity of its surface for bioactive substances such as cell-adhesive proteins. Although transparent HAp ceramics are prepared via a high-temperature and high-pressure sintering process, the composition and structure of the sintered HAp have limited variety, and are largely different from natural bone apatite. In this study, a low-crystallinity transparent HAp was developed via a low-temperature nanoparticle assembling conditions. The low-crystallinity transparent HAp developed here had nanosized pores among the particles, and showed low crystallinity with high surface area, which is largely different from the conventional transparent HAp sintered ceramics. Cell adhesion and proliferation on the low-crystallinity transparent HAp could be directly observed with an optical microscope, and significantly influenced by the nanostructure of the transparent HAp.

  17. 新規なフロートキャスト法によるナノセラミックス細胞足場材料の開発

    岡田正弘

    Offer Organization: 科学技術振興機構

    System: 研究成果最適展開支援プログラムフィージビリティスタディ【ＦＳ】ステージ 探索タイプ

    2011/08 - 2012/03

  18. Injectable Nano-Scaffolds, Hydroxyapatite-Polymer Nanocomposite Microsphere, Enhance the Therapeutic Angiogenesis by Cell Transplantation

    FUKUMOTO Shinya, KOYAMA Hidenori, FURUZONO Tsutomu, OKADA Masahiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Osaka City University

    2008 - 2010

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    Clinical trials demonstrate the effectiveness of cell-based therapeutic angiogenesis against patients with a variety of ischemic disease; however, the clinical success to date has been still limited. We have reported that nano-scaled sintered hydroxyapatite (HAp)-coating on artificial grafts reveals marked cell-adhesiveness, safety and high tissue-affinity. With this nanotechnology, the inorganic, biodegradable and injectable scaffold, HAp-coated poly L-lactic acid (PLLA) microsphere, has been generated : named nano-scaffold (NS). In this study, we examined its usefulness in cell-based therapeutic angiogenesis. Bone marrow-mononuclear cells (BMC) alone, with uncoated PLLAs (LA), or with HAp-coated microspheres (nano-scaffold : NS), were intramuscularly injected into mice ischemic hind-limbs generated by femoral artery occlusion. Kaplan-Meier analysis demonstrated that NS+BMC treatment markedly prevented limb necrosis after the operation (vs. BMC alone, and LA+BMC). Roles of NS to sustain BMC in ischemic tissues were demonstrated by the findings that immunohistochemistry revealed NS and BMC co-localized, and that NS+BMC group exhibited significantly elevated intramuscular levels of proangiogenic cytokines in ischemic tissues as compared with BMC alone. We demonstrated usefulness of injectable scaffold as an enhancer for cell-based therapeutic angiogenesis.

  19. Cell function on nano-surface of hydroxyapatite nanocrystal composite

    Masahiro Okada

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: National Cardiovascular Center Research Institute

    2007 - 2009

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    Cell functions of cells on hydroxyapatite (HAp) nanoparticles coated on polyethyleneterephtalete (PET) sheet were examined in detail. Cell adhesiveness and proliferation on HAp sheet was higher than original PET sheet. It was thought that the higher adhesion strength of cells on HAp substrate compare to the on original PET depend on cell anchoring on nano-structure and higher remodeling of extracellular matrix.

  20. ソフトプロセスによるアパタイト透明体の作製

    岡田 正弘

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 奨励研究

    Institution: 国立循環器病センター研究所

    2005 - 2005

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Social Activities 11

  1. ブース出展

    2022/12/11 - 2022/12/11

  2. ブース出展

    2021/12/12 - 2021/12/12

  3. ブース出展

    科学キッズフェスティバルin京山祭

    2020/12/13 - 2020/12/13

  4. ブース出展

    科学キッズフェスティバルin京山祭

    2019/12/08 - 2019/12/08

  5. ブース出展

    科学キッズフェスティバルin京山祭

    2019/02/24 - 2019/02/24

  6. ブース出展

    科学キッズフェスティバルin京山祭

    2017/12/10 - 2017/12/10

  7. ブース出展

    科学キッズフェスティバルin京山祭

    2016/12/11 - 2016/12/11

  8. バイオマテリアル〜医療のためのモノづくり

    高校生のための大学講座 (平成28年度教育連携協議会教育連携事業)

    2016/08/10 - 2016/08/10

  9. ブース出展

    科学キッズフェスティバルin京山祭

    2015/12/13 - 2015/12/13

  10. 無機微粒子の合成の基礎

    微粒子セミナー 〜基礎から応用まで〜

    2015/10/07 - 2015/10/07

  11. 無機微粒子の合成の基礎

    2014/10/08 - 2014/10/08

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Media Coverage 7

  1. 技術の森 出演 (Part 2)

    RSK山陽放送　朝耳らじお5.5

    2020/05/20

    Type: TV or radio program

  2. 技術の森 出演 (Part 1)

    RSK山陽放送　朝耳らじお5.5

    2020/05/13

    Type: TV or radio program

  3. 新聞記事掲載（チタン、金属接着材に）

    日刊工業新聞社　日刊工業新聞

    2020/04/24

    Type: Newspaper, magazine

  4. 新聞記事掲載（生体内にチップ、テープで固定）

    日経産業新聞社　日経産業新聞

    2020/04/07

    Type: Newspaper, magazine

  5. 新聞記事掲載（生体組織と瞬時に接着）

    日本経済新聞　日本経済新聞

    2020/04/05

    Type: Newspaper, magazine

  6. 新聞記事掲載（金属テープで体組織ぴたり）

    朝日新聞　朝日新聞社

    2020/03/23

    Type: Newspaper, magazine

  7. 新聞記事掲載（ちぎれた臓器ピタッ「夢の生体接着剤」 岡山大が開発）

    朝日新聞社　朝日新聞社

    2017/05/22

    Type: Newspaper, magazine

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Academic Activities 2

  1. 専門調査員

    2017/04/01 - Present

    Activity type: Academic research

  2. 日本歯科理工学会第78回秋期学術講演会準備委員長

    2021/10/16 - 2021/10/17

    Activity type: Academic society, research group, etc.