Details of the Researcher

PHOTO

Hiroshi Hoshijima
Section
Graduate School of Dentistry
Job title
Associate Professor
Degree
e-Rad No.
90536781

Professional Memberships 3

  • 日本ペインクリニック学会

  • 日本麻酔学会

  • 日本歯科麻酔学会

Research Areas 1

  • Other / Other /

Awards 4

  1. 優秀演題

    2022/10　日本歯科麻酔科学会　人工知能を応用した術後悪心嘔吐のリスク因子の同定

  2. 日本歯科麻酔科学会 (最優秀演題賞)

    2017/10　Conditioned pain modulationとthermal pain illusionは術後痛発症予測のバイオマーカーとなるか

  3. European Society of Anaesthesiologists (注目演題賞)

    2014/06　European Society of Anaesthesiologists

  4. Evidence-base Anesthesia 研究会 (最優秀演題受賞)

    2013/11

Papers 99

  1. Hemodynamic Response to Tracheal Intubation Using Indirect and Direct Laryngoscopes in Pediatric Patients: A Systematic Review and Network Meta-Analysis. International-journal

    Risa Takeuchi, Hiroshi Hoshijima, Masanori Tsukamoto, Shinichi Kokubu, Takahiro Mihara, Toshiya Shiga

    Children (Basel, Switzerland)　12　(6)　2025/06/16

    DOI： 10.3390/children12060786 　

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    Purpose: Hemodynamic response, particularly increased heart rate (HR) and blood pressure, can occur during tracheal intubation and is an adverse event to be avoided. The aim of this study was to use a network meta-analysis (NMA) to develop a ranking of hemodynamic responses (HR and mean blood pressure, MBP) after intubation of indirect and direct laryngoscopes in pediatric patients. Method: Studies were eligible for inclusion if they had a prospective randomized design, compared hemodynamic response (HR and MBP) to tracheal intubation between indirect and/or direct laryngoscopes, and were conducted in pediatric patients. The pooled difference between each intubation device's intubation time is expressed as a weighted mean difference (WMD) of a 95% confidence interval (CI). The intubation time of the device was evaluated using P-scores calculated from the network point estimates and standard errors. A random-effects model was used when pooling effect sizes. We also analyzed intubation time as a related factor to hemodynamic responses. Results: From the electronic databases, we selected 16 trials for review. In a Macintosh-referenced analysis, Airtraq suppressed an increase of HR and MBP during tracheal intubation in pediatric patients significantly more than a Macintosh laryngoscope. (HR; WMD = -16.7, 95%CI -22.5 to -10.9, MBP; WMD = -8.57, 95%CI -10.9 to -6.27). Airtraq also topped the HR and MBP P-score rankings. The results of this study showed similar laryngoscopes in the top five rankings of P-scores (Airtraq, Coopdech video laryngoscope, Miller, C-MAC, Wis-Hipple) for HR and intubation time. Conclusions: We applied a network meta-analysis to create a consistent ranking of intubation devices that prevent hemodynamic changes during tracheal intubation in pediatric patients. In this NMA, Airtraq proved to be the best laryngoscope for preventing hemodynamic responses during tracheal intubation in pediatric patients. In the analysis of intubation time, Airtraq showed the shortest intubation time.

  2. 歯科患者を対象とした歯科用局所麻酔剤アルチカイン塩酸塩・アドレナリン酒石酸水素塩注射剤(OKAD01)のリドカイン塩酸塩・アドレナリン酒石酸水素塩注射剤を対照とした有用性および安全性の検討(アルチカイン塩酸塩第III相試験)

    樋口 仁, 植野 高章, 三島 克章, 飯島 毅彦, 丹羽 均, 角南 次郎, 星島 宏, 水田 健太郎, 渡辺 禎久, 前田 茂, 中村 誠司, 細井 宏輝, 吉田 道弘, 宮脇 卓也

    日本歯科麻酔学会雑誌　53　(1)　1-12　2025/01

    Publisher: (一社)日本歯科麻酔学会

    ISSN： 0386-5835

    eISSN： 2433-4480

  3. Microbiological comparison of the disinfecting efficacy of small and large cotton swabs in nasotracheal intubation: a randomized trial. International-journal

    Makoto Hirohata, Naoko Tachi, Yuji Kamimura, Yoshiki Sento, Eisuke Kako, Hiroshi Hoshijima, Masahiro Okuda, Shota Tsukimoto, Kyoko Shida, Hidetaka Kuroda, Takuro Sanuki, Yuka Kikuchi, Kazuya Sobue, Yoshiaki Hasegawa, Aiji Sato-Boku

    BMC anesthesiology　24　(1)　414-414　2024/11/14

    DOI： 10.1186/s12871-024-02804-2 　

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    BACKGROUND: Nasotracheal intubation (NTI) is necessary during surgeries requiring clear access to the surgical field and in patients with respiratory issues. This study investigates the pre-NTI nasal disinfection efficacy of different cotton swab sizes, hypothesizing that smaller swabs could minimize bleeding while maintaining disinfection efficacy. METHODS: Patients classified as American Society of Anesthesiologists-physical status (ASA-PS) class 1 or 2 scheduled for general anesthesia with NTI were randomly assigned to either a large cotton swabs (LCS) or fine cotton swabs (FCS) group in this randomized controlled trial (RCT)." After anesthesia, a fine cotton swab was inserted into the inferior nasal meatus in both groups to collect bacteria (sample A). Next, the nasal cavity was disinfected with LCS or FCS according to the patient group. Bacteria were collected by inserting a fine cotton swab into the inferior nasal meatus (sample B). After surgery, bacteria were collected from the endotracheal tube tip using a fine cotton swab in both groups (sample C). The samples were cultured for 24 hours, and the colonies from samples A-C were counted. The changes in bacteria count between samples A and B and samples A and C were determined. Nasal bleeding from cotton swab insertion was assessed as a secondary outcome. Student's t-tests, a chi-square independence test, and Mann-Whitney U tests were used for the statistical analysis. The statistical significance level was set at p < 0.05. RESULTS: Between samples A and B, the change in bacteria count was 7.2% (1.4-26.1%) (median[interquartile range]) in the LCS group and 6.9% (0.9-22%) in the FCS group (p = 0.90). Between samples A and C, the change in bacteria count was 7.5% (0.2-44%) in the LCS group and 8.3% (0.3-39%) in the FCS group (p = 0.55). We examined 62 subjects in each group (LCS and FCS), and samples A, B, and C were collected from all participants in both groups. Nasal bleeding occurred in 42/62 in the LCS group and 22/62 in the FCS group (p < 0.01). CONCLUSION: Cotton swab thickness did not impact disinfection efficacy, but large swabs increased the risk of nasal bleeding. We recommend FCS for nasal disinfection prior to NTI in ASA 1-2 patients, as they reduce bleeding risk without compromising disinfection. TRIAL REGISTRATION: UMIN-CTR (registration no. UMIN000051495), June 30, 2023.

  4. Indirect laryngoscopy is more effective than direct laryngoscopy when tracheal intubation is performed by novice operators: a systematic review, meta-analysis, and trial sequential analysis. International-journal

    Hiroshi Hoshijima, Takahiro Mihara, Toshiya Shiga, Kentaro Mizuta

    Canadian journal of anaesthesia = Journal canadien d'anesthesie　71　(2)　201-212　2024/02

    DOI： 10.1007/s12630-023-02642-9 　

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    PURPOSE: We sought to perform a systematic review and meta-analysis to determine whether indirect laryngoscopy has an advantage over direct laryngoscopy in terms of the tracheal intubation rate, glottic visualization, and intubation time when used by novice operators. METHODS: We extracted adult prospective randomized trials comparing tracheal intubation with indirect vs direct laryngoscopy in novice operators from electronic databases. We extracted the following data from the identified studies: success rate, glottic visualization, and intubation time. Data from each trial were combined via a random-effects model to calculate the pooled relative risk (RR) or weighted mean difference (WMD) with a 95% confidence interval (CI). We also performed a trial sequential analysis. RESULTS: We included 15 articles (17 trials) comprising 2,290 patients in the systematic review. Compared with the direct laryngoscopy, indirect laryngoscopy improved success rate (RR, 1.15; 95% CI, 1.07 to 1.24; P = 0.0002; I2 = 88%), glottic visualization (RR, 1.76; 95% CI, 1.36 to 2.28; P < 0.001; I2 = 85%), and intubation time (WMD, -9.06 sec; 95% CI, -16.4 to -1.76; P = 0.01; I2 = 98%) in tracheal intubation. Trial sequential analysis showed that the total sample size was sufficient to analyze the success rate and intubation time. CONCLUSION: In this systematic review, we found that the tracheal intubation success rate, glottic visualization, and intubation time were improved when novice operators used indirect laryngoscopy rather than direct laryngoscopy. Trial sequential analysis results indicated that the sample size was sufficient for examining the success rate and intubation time. STUDY REGISTRATION: PROSPERO (CRD42022309045); first registered 4 September 2022.

  5. Machine learning-based identification of the risk factors for postoperative nausea and vomiting in adults. International-journal

    Hiroshi Hoshijima, Tomo Miyazaki, Yuto Mitsui, Shinichiro Omachi, Masanori Yamauchi, Kentaro Mizuta

    PloS one　19　(8)　e0308755　2024

    DOI： 10.1371/journal.pone.0308755 　

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    Postoperative nausea and vomiting (PONV) is a common adverse effect of anesthesia. Identifying risk factors for PONV is crucial because it is associated with a longer stay in the post-anesthesia care unit, readmissions, and perioperative costs. This retrospective study used artificial intelligence to analyze data of 37,548 adult patients (aged ≥20 years) who underwent surgery under general anesthesia at Tohoku University Hospital from January 1, 2010 to December 31, 2019. To evaluate PONV, patients who experienced nausea and/or vomiting or used antiemetics within 24 hours after surgery were extracted from postoperative medical and nursing records. We create a model that predicts probability of PONV using the gradient tree boosting model, which is a widely used machine learning algorithm in many applications due to its efficiency and accuracy. The model implementation used the LightGBM framework. Data were available for 33,676 patients. Total blood loss was identified as the strongest contributor to PONV, followed by sex, total infusion volume, and patient's age. Other identified risk factors were duration of surgery (60-400 min), no blood transfusion, use of desflurane for maintenance of anesthesia, laparoscopic surgery, lateral positioning during surgery, propofol not used for maintenance of anesthesia, and epidural anesthesia at the lumbar level. The duration of anesthesia and the use of either sevoflurane or fentanyl were not identified as risk factors for PONV. We used artificial intelligence to evaluate the extent to which risk factors for PONV contribute to the development of PONV. Intraoperative total blood loss was identified as the potential risk factor most strongly associated with PONV, although it may correlate with duration of surgery, and insufficient circulating blood volume. The use of sevoflurane and fentanyl and the anesthesia time were not identified as risk factors for PONV in this study.

  6. Comparison of Indirect and Direct Laryngoscopes in Pediatric Patients with a Difficult Airway: A Systematic Review and Meta-Analysis. International-journal

    Risa Takeuchi, Hiroshi Hoshijima, Takahiro Mihara, Shinichi Kokubu, Aiji Sato Boku, Takumi Nagumo, Tsutomu Mieda, Toshiya Shiga, Kentaro Mizuta

    Children (Basel, Switzerland)　11　(1)　2023/12/31

    DOI： 10.3390/children11010060 　

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    This meta-analysis was performed to determine whether an indirect laryngoscope is more advantageous than a direct laryngoscope for tracheal intubation in the setting of a difficult pediatric airway. Data on the intubation failure and intubation time during tracheal intubation were extracted from prospective and retrospective studies identified through a comprehensive literature search. Data from 10 individual articles (11 trials) were combined, and a DerSimonian and Laird random-effects model was used to calculate either the pooled relative risk (RR) or the weighted mean difference (WMD) and the corresponding 95% confidence interval (CI). Meta-analysis of the 10 articles indicated that the intubation failure of tracheal intubation with an indirect laryngoscope was not significantly different from that of a direct laryngoscope in patients with a difficult airway (RR 0.86, 95% CI 0.51-1.46; p = 0.59; Cochrane's Q = 50.5; I2 = 82%). Intubation time with an indirect laryngoscope was also similar to that with a direct laryngoscope (WMD 4.06 s; 95% CI -1.18-9.30; p = 0.13; Cochrane's Q 39.8; I2 = 85%). In conclusion, indirect laryngoscopes had the same intubation failure and intubation time as direct laryngoscopes in pediatric patients with a difficult airway. Currently, the benefits of indirect laryngoscopes have not been observed in the setting of a difficult pediatric airway.

  7. Incidence of long-term post-acute sequelae of SARS-CoV-2 infection related to pain and other symptoms: A systematic review and meta-analysis

    Hiroshi Hoshijima, Takahiro Mihara, Hiroyuki Seki, Shunsuke Hyuga, Norifumi Kuratani, Toshiya Shiga

    PLOS ONE　18　(11)　e0250909-e0250909　2023/11/29

    Publisher: Public Library of Science (PLoS)

    DOI： 10.1371/journal.pone.0250909 　

    eISSN： 1932-6203

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    Background Persistent symptoms are reported in patients who survive the initial stage of COVID-19, often referred to as “long COVID” or “post-acute sequelae of SARS-CoV-2 infection” (PASC); however, evidence on their incidence is still lacking, and symptoms relevant to pain are yet to be assessed. Methods A literature search was performed using the electronic databases PubMed, EMBASE, Scopus, and CHINAL and preprint servers MedRχiv and BioRχiv through January 15, 2021. The primary outcome was pain-related symptoms such as headache or myalgia. Secondary outcomes were symptoms relevant to pain (depression or muscle weakness) and symptoms frequently reported (anosmia and dyspnea). Incidence rates of symptoms were pooled using inverse variance methods with a DerSimonian-Laird random-effects model. The source of heterogeneity was explored using meta-regression, with follow-up period, age and sex as covariates. Results In total, 38 studies including 19,460 patients were eligible. Eight pain-related symptoms and 26 other symptoms were identified. The highest pooled incidence among pain-related symptoms was chest pain (17%, 95% confidence interval [CI], 11%-24%), followed by headache (16%, 95% CI, 9%-27%), arthralgia (13%, 95% CI, 7%-24%), neuralgia (12%, 95% CI, 3%-38%) and abdominal pain (11%, 95% CI, 7%-16%). The highest pooled incidence among other symptoms was fatigue (44%, 95% CI, 32%-57%), followed by insomnia (27%, 95% CI, 10%-55%), dyspnea (26%, 95% CI, 17%-38%), weakness (25%, 95% CI, 8%-56%) and anosmia (19%, 95% CI, 13%-27%). Substantial heterogeneity was identified (I2, 50–100%). Meta-regression analyses partially accounted for the source of heterogeneity, and yet, 53% of the symptoms remained unexplained. Conclusions The current meta-analysis may provide a complete picture of incidence in PASC. It remains unclear, however, whether post-COVID symptoms progress or regress over time or to what extent PASC are associated with age or sex.

  8. Successful Tracheal Intubation With Airway Scope After Failure With McGrath. International-journal

    Shiori Sasaki, Hiroshi Hoshijima, Makoto Yasuda, Kentaro Mizuta

    Anesthesia progress　70　(1)　17-19　2023/03/01

    DOI： 10.2344/anpr-69-03-01 　

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    The use of video laryngoscopy is growing in patients with anatomical factors suggestive of a difficult airway. This case report describes the successful tracheal intubation of a 54-year-old female patient with limited mouth opening scheduled for third molar extraction under general anesthesia. The Airway scope (AWS) along with a gum-elastic bougie was used to secure the airway after failed direct laryngoscopy and video laryngoscopy using the McGrath MAC with an X-blade. The AWS has a J-shaped structure in which the blade approximates the curvature of the pharynx and larynx. This blade shape makes it easy to match the laryngeal axis with the visual field direction, enabling successful tracheal intubation even for patients with limited mouth opening. A major key to successful video laryngoscopy is to select a video laryngoscope based on the anatomical characteristics of patients with a difficult airway.

  9. Sodium-glucose cotransporter 2 inhibitor-associated perioperative ketoacidosis: a systematic review of case reports

    Hiroyuki Seki, Satoshi Ideno, Toshiya Shiga, Hidenobu Watanabe, Motoaki Ono, Akira Motoyasu, Hikari Noguchi, Kazuya Kondo, Takahiro Yoshikawa, Hiroshi Hoshijima, Shunsuke Hyuga, Miho Shishii, Ai Nagai, Midoriko Higashi, Takashi Ouchi, Kazuki Yasuda, Norifumi Kuratani

    Journal of Anesthesia　2023/02/27

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s00540-023-03174-8 　

    ISSN： 0913-8668

    eISSN： 1438-8359

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    Abstract Although the recommended preoperative cessation period for sodium-glucose cotransporter 2 inhibitors (SGLT2is) changed in 2020 (from 24 h to 3–4 days preoperatively) to reduce the risk of SGLT2i-associated perioperative ketoacidosis (SAPKA), the validity of the new recommendation has not been verified. Using case reports, we assessed the new recommendation effectiveness and extrapolated precipitating factors for SAPKA. We searched electronic databases up to June 1, 2022 to assess SAPKA (blood pH &lt; 7.3 and blood or urine ketone positivity within 30 days postoperatively in patients taking SGLT2i). We included 76 publications with 99 cases. The preoperative SGLT2i cessation duration was reported for 59 patients (59.6%). In all cases with available cessation periods, the SGLT2is were interrupted &lt; 3 days preoperatively. No SAPKA cases with &gt; 2-day preoperative cessation periods were found. Many case reports lack important information for estimating precipitating factors, including preoperative SGLT2i cessation period, body mass index, baseline hemoglobin A1c level, details of perioperative fluid management, and type of anesthesia. Our study suggested that preoperative SGLT2i cessation for at least 3 days could prevent SAPKA. Large prospective epidemiologic studies are needed to identify risk factors for SAPKA.

  10. Hemodynamic response related to the Airway Scope versus the Macintosh laryngoscope: A systematic review and meta-analysis with trial sequential analysis

    Takumi Nagumo, Hiroshi Hoshijima, Koichi Maruyama, Takahiro Mihara, Tsutomu Mieda, Aiji Sato (Boku), Toshiya Shiga, Hiroshi Nagasaka

    Medicine　102　(8)　e33047-e33047　2023/02/22

    Publisher: Ovid Technologies (Wolters Kluwer Health)

    DOI： 10.1097/md.0000000000033047 　

    ISSN： 0025-7974

  11. 3M microfoam™ surgical tape prevents nasal pressure injury associated with nasotracheal intubation: A randomized double-blind trial Peer-reviewed

    Mayumi Hashimoto, Aiji Sato (Boku), Yoshiki Sento, Yuji Kamimura, Eisuke Kako, Masahiro Okuda, Naoko Tachi, Yoko Okumura, Izumi Kuroda, Hiroshi Hoshijima, Hidekazu Ito, Kazuya Sobue

    Medicine　102　(2)　e32679-e32679　2023/01/13

    Publisher: Ovid Technologies (Wolters Kluwer Health)

    DOI： 10.1097/md.0000000000032679 　

    eISSN： 1536-5964

  12. Nasal protection strategy reduces the incidence of nasal pressure injuries during nasotracheal intubation: Meta-analysis with trial sequential analysis

    Hiroshi Hoshijima, Takahiro Mihara, Takumi Nagumo, Aiji Sato (Boku), Toshiya Shiga, Kentaro Mizuta

    Medicine　101　(40)　e30638-e30638　2022/10/07

    Publisher: Ovid Technologies (Wolters Kluwer Health)

    DOI： 10.1097/md.0000000000030638 　

    eISSN： 1536-5964

  13. 各社左用二腔気管チューブの付属スタイレットの特性(第3報)

    輪嶋 善一郎, 志賀 俊哉, 今永 和幸, 星島 宏

    日本臨床麻酔学会誌　42　(6)　S256-S256　2022/10

    Publisher: 日本臨床麻酔学会

    ISSN： 0285-4945

    eISSN： 1349-9149

  14. SGLT2阻害薬に関連した周術期ケトアシドーシスに関するシステマティックレビュー

    関 博志, 星島 宏, 日向 俊輔, 渡辺 英伸, 本保 晃, 近藤 一哉, 永井 亜依, 吉川 貴紘

    日本臨床麻酔学会誌　42　(6)　S181-S181　2022/10

    Publisher: 日本臨床麻酔学会

    ISSN： 0285-4945

    eISSN： 1349-9149

  15. 3Mマイクロフォームサージカルテープは経鼻挿管に伴う圧迫創傷を予防する 無作為化二重盲検試験

    橋本 真弓, 佐藤 會士, 星島 宏, 原田 笑莉香, 浅井 茉美, 廣畑 誠人, 鹿間 優子, 奥田 真弘

    日本歯科麻酔学会雑誌　50　(抄録号)　135-135　2022/09

    Publisher: (一社)日本歯科麻酔学会

    ISSN： 0386-5835

    eISSN： 2433-4480

  16. 人工知能を応用した術後悪心嘔吐のリスク因子の同定

    星島 宏, 水田 健太郎

    日本歯科麻酔学会雑誌　50　(抄録号)　126-126　2022/09

    Publisher: (一社)日本歯科麻酔学会

    ISSN： 0386-5835

    eISSN： 2433-4480

  17. SAPHO症候群患者に対する全身麻酔経験

    武田 桜, 星島 宏, 水田 健太郎

    日本歯科麻酔学会雑誌　50　(抄録号)　186-186　2022/09

    Publisher: (一社)日本歯科麻酔学会

    ISSN： 0386-5835

    eISSN： 2433-4480

  18. Effectiveness of Indirect and Direct Laryngoscopes in Pediatric Patients: A Systematic Review and Network Meta-Analysis. International-journal Peer-reviewed

    Hiroshi Hoshijima, Takahiro Mihara, Shinichi Kokubu, Sakura Takeda, Toshiya Shiga, Kentaro Mizuta

    Children (Basel, Switzerland)　9　(9)　2022/08/25

    DOI： 10.3390/children9091280 　

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    This research aimed to produce a coherent ranking of the effectiveness of intubation devices in pediatric patients using network meta-analysis (NMA). We searched the electric databases for prospective randomized studies that compared different tracheal intubation devices in pediatric patients. The primary outcome was intubation failure at the first attempt. Secondary outcomes were glottic visualization and intubation time. The statistical analysis performed used DerSimonian and Laird random-effects models. Frequentist network meta-analysis was conducted, and network plots and network league tables were produced. Subgroup analysis was performed after excluding rigid-fiberscope-type indirect laryngoscopes. Thirty-four trials comparing 13 devices were included. Most laryngoscopes had the same intubation failure rate as the Macintosh reference device. Only the Truview PCD™ had a significantly higher intubation failure rate than the Macintosh (odds ratio 4.78, 95% confidence interval 1.11-20.6) The highest-ranking laryngoscope was the Airtaq™ (P score, 0.90), and the AirwayScope™, McGrath™, and Truview EVO2™ ranked higher than the Macintosh. The Bullard™ had the lowest ranking (P score, 0.08). All laryngoscopes had the same level of glottic visualization as the Macintosh and only the C-MAC™ had a significantly shorter intubation time. Intubation time was significantly longer when using the GlideScope™, Storz DCI™, Truview PCD™, or Bullard™ compared with the Macintosh. P score and ranking of devices in the subgroup analyses were similar to those in the main analysis. We applied NMA to create a consistent ranking of the effectiveness of intubation devices in pediatric patients. The findings of NMA suggest that there is presently no laryngoscope superior to the Macintosh laryngoscope in terms of tracheal intubation failure rate and glottic visualization in pediatric patients.

  19. 新型コロナウイルス感染後後遺症の頻度に関するメタアナリシス

    志賀 俊哉, 星島 宏, 水原 敬洋, 関 博志

    国際医療福祉大学学会誌　27　(抄録号)　194-194　2022/08

    Publisher: 国際医療福祉大学学会

    ISSN： 2186-3652

  20. Airtraq® versus GlideScope® for tracheal intubation in adults: a systematic review and meta-analysis with trial sequential analysis. International-journal Peer-reviewed

    Hiroshi Hoshijima, Takahiro Mihara, Yohei Denawa, Toshiya Shiga, Kentaro Mizuta

    Canadian journal of anaesthesia = Journal canadien d'anesthesie　69　(5)　605-613　2022/05

    DOI： 10.1007/s12630-022-02217-0 　

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    PURPOSE: In recent years, various types of indirect laryngoscopes have been developed. Nevertheless, no conclusions have been drawn about which type of indirect laryngoscope is most effective for tracheal intubation. We performed a systematic review and meta-analysis to determine whether the Airtraq® or the GlideScope® is more effective for tracheal intubation. METHODS: We extracted studies of adult prospective randomized trials comparing tracheal intubation between the Airtraq and GlideScope. An electronic database was used to extract the studies included in our meta-analysis. We extracted the following data from the identified studies: success rate, glottic visualization, and intubation time. Data from each trial were combined via a random-effects model for calculation of pooled relative risk (RR) or weighted mean difference (WMD) with a 95% confidence interval (CI). We also performed trial sequential analysis. RESULTS: We included eight trials comprising 571 patients for review. Compared with the GlideScope, Airtraq did not improve success rate, glottic visualization, or intubation time in tracheal intubation (success rate: RR, 0.98; 95% CI, 0.91 to 1.05; P = 0.58; I2 = 65%; glottic visualization: RR, 1.07; 95% CI, 0.88 to 1.29; P = 0.69; I2 = 64%; and intubation time: WMD, 1.4 seconds ; 95% CI, -6.2 to 9.1; P = 0.72; I2 = 96%). The quality of evidence was graded as "very low." Trial sequential analysis showed that total sample size did not reach the required information size for all parameters. CONCLUSION: In this meta-analysis, use of the Airtraq indirect laryngoscope did not result in improved success rate, glottic visualization, or intubation time in tracheal intubation compared with the GlideScope. Trial sequential analysis suggests that further studies are necessary to confirm these findings.

  21. Anesthetic management with remimazolam for a pediatric patient with Duchenne muscular dystrophy Peer-reviewed

    Yuta Horikoshi, Norifumi Kuratani, Ken Tateno, Hiroshi Hoshijima, Tina Nakamura, Tsutomu Mieda, Katsushi Doi, Hiroshi Nagasaka

    Medicine　100　(49)　e28209-e28209　2021/12/10

    Publisher: Ovid Technologies (Wolters Kluwer Health)

    DOI： 10.1097/md.0000000000028209 　

    ISSN： 0025-7974

    eISSN： 1536-5964

  22. Systematic Review of Systemic and Neuraxial Effects of Acetaminophen in Preclinical Models of Nociceptive Processing Peer-reviewed

    Hiroshi Hoshijima, Matthew Hunt, Hiroshi Nagasaka, Tony Yaksh

    Journal of Pain Research　Volume 14　3521-3552　2021/11

    Publisher: Informa UK Limited

    DOI： 10.2147/jpr.s308028 　

    eISSN： 1178-7090

  23. 各社左用二腔気管チューブの付属スタイレットの特性(第1報)

    輪嶋 善一郎, 志賀 俊哉, 今永 和幸, 星島 宏

    日本臨床麻酔学会誌　41　(6)　S242-S242　2021/10

    Publisher: 日本臨床麻酔学会

    ISSN： 0285-4945

    eISSN： 1349-9149

  24. 小児鎮静の適応とリスク 小児歯科治療の鎮静(小児鎮静の適応とリスク)

    星島 宏, 水田 健太郎

    日本小児麻酔学会大会プログラム　26回　7-7　2021/10

    Publisher: (一社)日本小児麻酔学会

  25. Comparison of hemostatic effect and safety between epinephrine and tramazoline during nasotracheal intubation: a double-blind randomized trial. International-journal

    Aiji Sato-Boku, Yoshiki Sento, Yuji Kamimura, Eisuke Kako, Masahiro Okuda, Naoko Tachi, Yoko Okumura, Mayumi Hashimoto, Hiroshi Hoshijima, Fumihito Suzuki, Kazuya Sobue

    BMC anesthesiology　21　(1)　235-235　2021/09/30

    DOI： 10.1186/s12871-021-01454-y 　

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    BACKGROUND: Nasal bleeding is the most common complication during nasotracheal intubation (NTI). To reduce nasal bleeding, the nasal mucosa is treated with vasoconstrictors (epinephrine [E] or tramazoline [T]) prior to NTI. This study aimed to determine whether E or T is more effective and safe for reducing nasal bleeding during NTI. METHODS: This study was preregistered on UMIN-CTR after being approved by the IRB of the School of Dentistry at Aichi Gakuin University. Written consent was received from all the patients. Total 206 patients aged 20-70 years and classified as 1-2 on American Society of Anesthesiologists-physical status were scheduled to undergo general anesthesia with NTI. At last, 197 patients were randomly divided into two groups and treated with either E (n = 99; 3 patients were discontinued) or T (n = 98; 2 patient were discontinued). After induction of general anesthesia, each patient's nasal mucosa was treated using either E or T. The E used in this study was BOSMIN® SOLUTION 0.1% (Daiichi-Sankyo Co., Ltd., Tokyo), and the T used in this study was TRAMAZOLIN Nasal Solution 0.118% AFP, (Alfresa Pharma Corporation, Osaka). E was diluted five times according to the package insert (final concentration of E = 0.02%), and T was used in its original solution. After 2 min, NTI was performed via the right nostril. Primary outcome were the presence of nasal bleeding (if bleeding was recognized at the posterior pharyngeal wall via nasal cavity during intubation, it was defined as bleeding) and the degree of bleeding (classified as none, mild, moderate, or severe). Secondary outcomes were arrhythmia, and hemodynamic (mean atrial pressure and heart rate) changes associated with vasoconstrictors. RESULTS: The presence of bleeding was comparable in both groups (12.5%, E; 14.5%, T; P = 0.63). No significant difference between the groups regarding the degree of bleeding (P = 0.78) was observed, with most patients having no bleeding (n = 84, E; n = 82, T). No severe bleeding and no arrhythmias induced by vasoconstrictor were observed in the two groups. CONCLUSIONS: Nasal treatment with E or T shows no difference in nasal bleeding during NTI. Although no arrhythmia associated with E was observed in this study, it has been reported in literature. Therefore, as frequency and degree of nasal bleeding were comparable, nasal treatment with T could reduce the risk of NTI. TRIAL REGISTRATION: UMIN-CTR (Registration No. UMIN000037907 ). Registered (05/09/2019).

  26. Patient satisfaction with deep versus light/moderate sedation for non-surgical procedures: A systematic review and meta-analysis. International-journal Peer-reviewed

    Hiroshi Hoshijima, Hitoshi Higuchi, Aiji Sato Boku, Makiko Shibuya, Yoshinari Morimoto, Toshiaki Fujisawa, Kentaro Mizuta

    Medicine　100　(36)　e27176　2021/09/10

    DOI： 10.1097/MD.0000000000027176 　

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    BACKGROUND: Deep sedation relieves a patient's anxiety and stress during the procedure by inducing patient unconsciousness. However, it remains unclear whether deep sedation actually improves patient satisfaction with the procedure. Therefore, we performed a systematic review and meta-analysis to compare the satisfaction of patients undergoing deep sedation with that of those undergoing light/moderate sedation during non-surgical procedures. METHODS: A comprehensive literature search was performed using electronic databases (search until September 2020). The primary outcome was whether patient satisfaction was higher after deep sedation or light/moderate sedation. The secondary outcome was the relative safety of deep sedation compared with light/moderate sedation in terms of oxygen saturation, systolic blood pressure, and heart rate. The tertiary outcomes were the relative procedure and recovery times for deep versus light/moderate sedation.Data from each of the trials were combined, and calculations were made using DerSimonian and Laird random effects models. The pooled effect estimates for patient satisfaction were evaluated using relative risk (RR) with the 95% confidence interval (CI). The pooled effect estimates for continuous data are expressed as weighted mean difference with the 95% CI. We assessed heterogeneity with the Cochrane Q statistic and the I2 statistic. The risk of bias assessment and Grading of Recommendations Assessment, Development and Evaluation approach were used as the quality assessment method. RESULTS: After removing unrelated studies and applying the exclusion criterion, 5 articles satisfied the inclusion criteria. Patient satisfaction was significantly higher in those who received deep sedation compared with light/moderate sedation (relative risk = 1.12; 95% CI, 1.04-1.20; P = .003; Cochrane Q = 25.0; I2 = 76%).There was no significant difference in oxygen saturation, systolic blood pressure, heart rate, and procedure times according to whether the procedures were performed under deep or light/moderate sedation. However, the recovery time was significantly prolonged in patients under deep sedation. CONCLUSIONS: Our meta-analysis suggests that deep sedation resulted in improved patient satisfaction compared with light/moderate sedation. Deep sedation is recommended for patients undergoing procedures because it improves patient satisfaction. However, respiration and circulation should be carefully monitored both intra-operatively and postoperatively.

  27. 若年発症成人型糖尿病(MODY3)患者の顎矯正手術に対する全身麻酔管理経験

    工藤 葉子, 星島 宏, 石川 実花, 水田 健太郎

    日本歯科麻酔学会雑誌　49　(抄録号)　137-137　2021/09

    Publisher: (一社)日本歯科麻酔学会

    ISSN： 0386-5835

    eISSN： 2433-4480

  28. Effects of intrathecal opioids on cesarean section: a systematic review and Bayesian network meta-analysis of randomized controlled trials. Peer-reviewed

    Hiroyuki Seki, Toshiya Shiga, Takahiro Mihara, Hiroshi Hoshijima, Yuki Hosokawa, Shunsuke Hyuga, Tomoe Fujita, Kyotaro Koshika, Reina Okada, Hitomi Kurose, Satoshi Ideno, Takashi Ouchi

    Journal of anesthesia　35　(6)　911-927　2021/08/02

    DOI： 10.1007/s00540-021-02980-2 　

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    PURPOSE: We aimed to compare the beneficial and harmful effects of opioids used as adjuncts to local anesthetics in patients undergoing cesarean section under spinal anesthesia. METHODS: We searched electronic databases and ClinicalTrials.gov from their inception until March, 2021 without language restrictions. The primary outcome was the complete analgesia duration (Time to VAS > 0). Data were synthesized using the Bayesian random-effects model. Evidence confidence was evaluated using the Confidence In Network Meta-Analysis. RESULTS: We identified 66 placebo-controlled randomized controlled trials (RCTs) comprising 4400 patients undergoing elective cesarean section. Compared with the placebo, intrathecal opioids (fentanyl, sufentanil, and morphine) significantly prolonged the analgesia duration by 96, 96, and 190 min, respectively (mean difference). Despite morphine ranking first, opioid efficacy was similar; the results were inconsistent with respect to other analgesic outcomes. Except for diamorphine, all opioids were associated with significant increases in the pruritus incidence. Sufentanil and morphine were associated with increases in the respiratory depression incidence. CONCLUSIONS: We confirmed that intrathecal opioids benefit postoperative analgesia. Although morphine seems to be the most appropriate agent, some results were inconsistent, and the evidence confidence was often moderate or low, especially for adverse outcomes. Well-designed RCTs with an evidence-based approach are imperative for determining the most appropriate opioid for cesarean sections.

  29. Asystole Triggered by the Mouth Opening With a Dental Mouth Gag Under General Anesthesia During Pediatric Oral Surgery: Report of a Rare Case. International-journal Peer-reviewed

    Hiroshi Hoshijima, Risa Takeuchi, Kimiharu Kikuchi, Kentaro Mizuta

    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons　79　(9)　1862-1865　2021/03/26

    DOI： 10.1016/j.joms.2021.03.016 　

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    The trigeminovagal reflex manifests as a sudden onset of bradycardia, hypotension, and cardiac arrest in response to the stimulation of the trigeminal nerve. The incidence of trigeminovagal reflex in maxillofacial surgical procedures is approximately 1.6%. We report a case of asystole in a pediatric patient in whom a dental mouth gag triggered the trigeminovagal reflex during oral surgery. The patient was a 5-year-old boy who was scheduled to undergo extraction of the maxillary supernumerary teeth. After tracheal intubation, anesthesia was maintained with sevoflurane and remifentanil. At the beginning of the surgery, his mouth was opened with a dental mouth gag, and electrocardigram showed asystole for 20 second. Thereafter, his heart rate spontaneously returned to basal value within 60 second. Since sufficient mouth opening was required to conduct the surgery, his mouth was opened again with the gag. When the interincisal distance exceeded about 40 mm, his heart rate suddenly decreased, but spontaneously returned to baseline within 60 second. The subsequent anesthetic course was uneventful.

  30. Comparison of polyurethane tracheal tube cuffs and conventional polyvinyl chloride tube cuff for prevention of ventilator-associated pneumonia: A systematic review with meta-analysis. International-journal Peer-reviewed

    Minami Saito, Koichi Maruyama, Takahiro Mihara, Hiroshi Hoshijima, Go Hirabayashi, Tomio Andoh

    Medicine　100　(9)　e24906　2021/03/05

    DOI： 10.1097/MD.0000000000024906 　

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    BACKGROUND: The aim of this meta-analysis with trial sequential analysis (TSA) was to evaluate the effect of a polyurethane (PU) tracheal tube cuff on the prevention of ventilator-associated pneumonia (VAP). METHODS: We performed a systematic search using the MEDLINE database through PubMed, Cochrane Central Register of Controlled Trial, SCOPUS, and Web of Science.Randomized controlled trials comparing the incidence of VAP and clinically relevant outcomes between PU cuff tubes and polyvinyl chloride (PVC) cuff tubes in adult patients. Two authors independently extracted study details, patient characteristics, and clinical outcomes such as incidence of VAP, bacterial colonization of tracheal aspirate, duration of mechanical ventilation, ICU stay, and ICU mortality. RESULTS: From 309 studies identified as potentially eligible, six studies with 1226 patients were included in this meta-analysis. All studies compared the incidence of VAP between PU cuffs and PVC cuffs. Use of a PU cuff was not associated with a reduction in VAP incidence (RR = 0.68; 95% CI, 0.45-1.03) with significant statistical heterogeneity (I2 = 65%). The quality of evidence was "very low." According to the TSA, the actual sample size was only 15.8% of the target sample size, and the cumulative Z score did not cross the trial sequential monitoring boundary for benefit. No positive impact was reported for the other relevant outcomes for PU cuffs. CONCLUSIONS: The use of a PU cuff for mechanical ventilation did not prevent VAP. Further trials with a low risk of bias need to be performed.

  31. Ringer's acetate solution-induced precipitation of remimazolam. International-journal Peer-reviewed

    Haruka Sasaki, Hiroshi Hoshijima, Kentaro Mizuta

    British journal of anaesthesia　126　(3)　e87-e89　2021/03

    DOI： 10.1016/j.bja.2020.11.021 　

  32. Use of the GlideScope does not lower the hemodynamic response to tracheal intubation more than the Macintosh laryngoscope: a systematic review and meta-analysis. International-journal Peer-reviewed

    Hiroshi Hoshijima, Koichi Maruyama, Takahiro Mihara, Aiji Sato Boku, Toshiya Shiga, Hiroshi Nagasaka

    Medicine　99　(48)　e23345　2020/11/25

    DOI： 10.1097/MD.0000000000023345 　

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    BACKGROUND: It is presently unclear whether the hemodynamic response to intubation is less marked with indirect laryngoscopy using the GlideScope (GlideScope) than with direct laryngoscopy using the Macintosh laryngoscope. Thus, the aim of this study was to determine whether using the GlideScope lowers the hemodynamic response to tracheal intubation more than using the Macintosh laryngoscope. METHODS: We performed a comprehensive literature search of electronic databases for clinical trials comparing hemodynamic response to tracheal intubation. The primary aim was to determine whether the heart rate (HR) and mean blood pressure (MBP) 60 s after tracheal intubation with the GlideScope were lower than after intubation with the Macintosh laryngoscope. We expressed pooled differences in HR and MBP between the devices as the weighted mean difference with 95% confidence interval and also performed trial sequential analysis (TSA). Second, we examined whether use of the GlideScope resulted in lower post-intubation hemodynamic responses at 120, 180, and 300 s compared with use of the Macintosh laryngoscope. For sensitivity analysis, we used a multivariate random effects model that accounted for within-study correlation of the longitudinal data. RESULTS: The literature search identified 13 articles. HR and MBP at 60 seconds post-intubation was not significantly lower with the GlideScope than with the Macintosh (HR vs MBP: weighted mean difference = 0.22 vs 2.56; 95% confidence interval -3.43 to 3.88 vs -0.82 to 5.93; P = .90 vs 0.14; I = 77% vs 63%: Cochran Q, 52.7 vs 27.2). Use of the GlideScope was not associated with a significantly lower HR or MBP at 120, 180, or 300 s post-intubation. TSA indicated that the total sample size was over the futility boundary for HR and MBP. Sensitivity analysis indicated no significant association between use of the GlideScope and a lower HR or MBP at any measurement point. CONCLUSIONS: Compared with the Macintosh laryngoscope, the GlideScope did not lower the hemodynamic response after tracheal intubation. Sensitivity analysis results supported this finding, and the results of TSA suggest that the total sample size exceeded the TSA monitoring boundary for HR and MBP.

  33. Anesthetic management in MAO-A and MAO-B deficiency: a case report. Peer-reviewed

    Hiroshi Hoshijima, Risa Takeuchi, Kimiharu Kikuchi, Kentaro Mizuta

    Journal of anesthesia　34　(5)　773-776　2020/10

    DOI： 10.1007/s00540-020-02808-5 　

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    Monoamine oxidase (MAO) deficiency is an X-linked hereditary disease characterized by spontaneous deletion of MAO-A and/or MAO-B on the X chromosome. Here, we describe the first reported case of a patient with MAO-A and MAO-B deficiency managed under general anesthesia in dental treatment. The patient was aged 11 years old when he was scheduled for dental treatment. He was diagnosed with MAO-A and MAO-B deficiency on genetic testing at 2 years of age. He was not given premedication, and standard monitoring with noninvasive blood pressure monitoring, pulse oximetry, and ECG was instituted. We also preemptively prepared a cardioverter-defibrillator. General anesthesia was induced with propofol 46 mg (2 mg/kg), then rocuronium 10 mg (0.4 mg/kg) and remifentanil 0.30 μg/kg/min were administered via separate infusion pumps. Orotracheal intubation was performed without complications. Anesthesia was maintained uneventfully with a continuous infusion of remifentanil 0.15-0.2 μg/kg/min and propofol 5.0-7.0 mg/kg. Fresh gas flow included oxygen and air. End-tidal CO2 concentration was maintained at around 35 mmHg throughout the procedure. We administered sugammadex 92 mg (4 mg/kg) for reversal of neuromuscular blockade and the patient was extubated. We achieved successful anesthetic management without any appreciable clinical signs of fatal arrhythmias in this patient with MAO-A and MAO-B deficiency.

  34. 挿管困難患者におけるMcGrathビデオ喉頭鏡とMacintosh型喉頭鏡の気管挿管時の比較 meta-analysis

    星島 宏, 竹内 梨紗, 菊地 公治, 水田 健太郎

    日本歯科麻酔学会雑誌　48　(抄録号)　124-124　2020/09

    Publisher: (一社)日本歯科麻酔学会

    ISSN： 0386-5835

    eISSN： 2433-4480

  35. 歯科麻酔学臨床実習における双方向性オンライン教育プログラムの導入

    工藤 葉子, 田中 志典, 星島 宏, 佐々木 詩織, 佐々木 晴香, 関口 香, 柴田 菫, 真藤 裕基, 高山 紘子, 安田 真, 水田 健太郎

    日本歯科麻酔学会雑誌　48　(抄録号)　142-142　2020/09

    Publisher: (一社)日本歯科麻酔学会

    ISSN： 0386-5835

    eISSN： 2433-4480

  36. Comparison of Hemodynamic Responses to Administration of Vasopressin and Norepinephrine Under General Anesthesia: A Systematic Review and Meta-analysis of Randomized Controlled Trials with Trial Sequential Analysis. International-journal Peer-reviewed

    Hiroshi Hoshijima, Takahiro Mihara, Yohei Denawa, Toshiya Shiga, Kentaro Mizuta

    Journal of cardiothoracic and vascular anesthesia　35　(1)　61-69　2020/08/11

    DOI： 10.1053/j.jvca.2020.08.011 　

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    OBJECTIVE: The authors performed a meta-analysis to determine if vasopressin improves hypotension more than norepinephrine under general anesthesia. DESIGN: Meta-analysis. SETTING: Operating room. PATIENTS: Patients who underwent surgery, with general anesthesia. INTERVENTIONS: Administration of vasopressin or norepinephrine in order to increase blood pressure. MEASUREMENTS AND MAIN RESULTS: The primary outcome of this study was to determine if vasopressin increased mean blood pressure more effectively compared with norepinephrine for patients under general anesthesia. The secondary outcome was to see if vasopressin increased heart rate (HR), central venous pressure (CVP), cardiac output (CO), and cardiac index (CI) more significantly compared with norepinephrine under general anesthesia. The authors calculated the weighted mean difference, with 95% confidence interval (CI) using the random-effects model, and calculated the required information size (RIS) by performing trial sequential analysis (TSA). The authors selected 6 studies for analysis. Vasopressin did not improve hypotension compared with norepinephrine under general anesthesia. (weighted mean difference = -0.84 mmHg, 95% CI: -5.90 to 4.23, p = 0.75, Cochran Q = 24.6, I2 = 84%) In TSA, only 35.5% of RIS was achieved. Similarly, vasopressin and norepinephrine were not significantly different in terms of HR, CVP, CO, and CI. In TSA, only 23.7% of the RIS was reached for HR but RIS was almost achieved for CVP and CO. CONCLUSIONS: Vasopressin did not improve hypotension compared with norepinephrine under general anesthesia. The RIS was not reached in TSA, and Grading of Recommendations Assessment, Development and Evaluation is very low. Therefore, further research is needed to reach more robust conclusions.

  37. Anestesia para paciente com cardiomiopatia arritmogênica do ventrículo direito portador de cardioversor desfibrilador implantável: descrição de caso Peer-reviewed

    Yoko Ohyama, Hiroshi Hoshijima, Jun Shimada

    Brazilian Journal of Anesthesiology　70　(3)　302-305　2020/05

    Publisher: Elsevier BV

    DOI： 10.1016/j.bjan.2020.02.002 　

    ISSN： 0034-7094

  38. 歯科麻酔専門医・認定医における深鎮静の現状認識調査報告 Peer-reviewed

    渋谷 真希子, 佐藤 會士[朴], 樋口 仁, 星島 宏, 森本 佳成, 藤澤 俊明, 日本歯科麻酔学会歯科麻酔医のための深鎮静ガイドライン策定小部会

    日本歯科麻酔学会雑誌　48　(1)　22-29　2020/01

    Publisher: (一社)日本歯科麻酔学会

    ISSN： 0386-5835

    eISSN： 2433-4480

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    日本歯科麻酔学会歯科麻酔専門医全員292名と歯科麻酔認定医資格のみ有する歯科麻酔医から無作為に抽出した308名を対象として、2018年8月に電子メールにより深鎮静に対する現状意識に関するアンケート調査を実施した。回答率は40.2%であり、歯科麻酔専門医が154名、歯科麻酔認定医資格のみを有する者が87名であった。所属する施設で深鎮静が行われていた割合は71.4%であった。アメリカ麻酔学会(ASA)の呼びかけや刺激に対する反応から見た鎮静深度区分(「ASA鎮静深度区分」)とRamsay's sedation scaleを融合かつ改変して鎮静深度スコア1〜6を作成し、回答者が考える深鎮静の深度範囲を調査した結果、「ASA鎮静深度区分」で中等度鎮静に属するスコア5-aを「最浅」と選択したものが多く(40.7%)、「最深」と考えるスコアはスコア5-cとスコア6がそれぞれ41.9%、36.1%で拮抗するなど、「最浅」「最深」ともにその範囲の選択は多様であった。

  39. Association of hospital and surgeon volume with mortality following major surgical procedures: Meta-analysis of meta-analyses of observational studies. International-journal Peer-reviewed

    Hiroshi Hoshijima, Zen'ichiro Wajima, Hiroshi Nagasaka, Toshiya Shiga

    Medicine　98　(44)　e17712　2019/11

    DOI： 10.1097/MD.0000000000017712 　

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    Accumulation of the literature has suggested an inverse association between healthcare provider volume and mortality for a wide variety of surgical procedures. This study aimed to perform meta-analysis of meta-analyses (umbrella review) of observational studies and to summarize existing evidence for associations of healthcare provider volume with mortality in major operations.We searched MEDLINE, SCOPUS, and Cochrane Library, and screening of references.Meta-analyses of observational studies examining the association of hospital and surgeon volume with mortality following major operations. The primary outcome is all-cause short-term morality after surgery. Meta-analyses of observational studies of hospital/surgeon volume and mortality were included. Overall level of evidence was classified as convincing (class I), highly suggestive (class II), suggestive (class III), weak (class IV), and non-significant (class V) based on the significance of the random-effects summary odds ratio (OR), number of cases, small-study effects, excess significance bias, prediction intervals, and heterogeneity.Twenty meta-analyses including 4,520,720 patients were included, with 19 types of surgical procedures for hospital volume and 11 types of surgical procedures for surgeon volume. Nominally significant reductions were found in odds ratio in 82% to 84% of surgical procedures in both hospital and surgeon volume-mortality associations. To summarize the overall level of evidence, however, only one surgical procedure (pancreaticoduodenectomy) fulfilled the criteria of class I and II for both hospital and surgeon volume and mortality relationships, with a decrease in OR for hospital (0.42, 95% confidence interval[CI] [0.35-0.51]) and for surgeon (0.38, 95% CI [0.30-0.49]), respectively. In contrast, most of the procedures appeared to be weak or "non-significant."Only a very few surgical procedures such as pancreaticoduodenectomy appeared to have convincing evidence on the inverse surgeon volume-mortality associations, and yet most surgical procedures resulted in having weak or "non-significant" evidence. Therefore, healthcare professionals and policy makers might be required to steer their centralization policy more carefully unless more robust, higher-quality evidence emerges, particularly for procedures considered as having a weak or non-significant evidence level including total knee replacement, thyroidectomy, bariatric surgery, radical cystectomy, and rectal and colorectal cancer resections.

  40. 歯科麻酔医の深鎮静に関する施設実態調査報告 Peer-reviewed

    渋谷 真希子, 佐藤 會士[朴], 樋口 仁, 星島 宏, 森本 佳成, 藤澤 俊明, 日本歯科麻酔学会歯科麻酔医のための深鎮静ガイドライン策定小部会

    日本歯科麻酔学会雑誌　47　(4)　158-164　2019/10

    Publisher: (一社)日本歯科麻酔学会

    ISSN： 0386-5835

    eISSN： 2433-4480

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    歯科麻酔医が勤務する歯科施設を対象に深鎮静管理に関するアンケート調査を行った。その結果、189施設中109施設(57.7%)から回答が得られた。深鎮静の定義に関しては56.9%の施設で共通した定義がなく、また、定義のある施設でも文書化されているのは10.6%であった。実際に深鎮静を行っている施設は76.1%であった。気道管理に関わる偶発症を経験した施設の割合は、重複を含め、喉頭痙攣が12.0%、誤嚥が24.1%、気管挿管やBag-valve-maskによる対応を要した気道閉塞・呼吸抑制が36.1%であった。今回の検討ではスタッフ間で深鎮静に対する共通した認識があるとは限らないことや、意識下鎮静と比べ偶発症のリスクが高い可能性が示唆された。

  41. Airtraq® is superior to the Macintosh laryngoscope for tracheal intubation: Systematic review with trial sequential analysis. International-journal Peer-reviewed

    Hiroshi Hoshijima, Takahiro Mihara, Yohei Denawa, Michiro Ozaki, Ichirota Naya, Toshiya Shiga, Hiroshi Nagasaka

    The American journal of emergency medicine　37　(7)　1367-1368　2019/07

    DOI： 10.1016/j.ajem.2018.12.018 　

    ISSN： 0735-6757

  42. C-MAC videolaryngoscope versus Macintosh laryngoscope for tracheal intubation: A systematic review and meta-analysis with trial sequential analysis. Peer-reviewed

    Hoshijima H, Mihara T, Maruyama K, Denawa Y, Mizuta K, Shiga T, Nagasaka H

    J Clin Anesth　43　53-62　2018/10

  43. C-MAC videolaryngoscope versus Macintosh laryngoscope for tracheal intubation: A systematic review and meta-analysis with trial sequential analysis. International-journal Peer-reviewed

    Hiroshi Hoshijima, Takahiro Mihara, Koichi Maruyama, Yohei Denawa, Kentaro Mizuta, Toshiya Shiga, Hiroshi Nagasaka

    Journal of clinical anesthesia　49　53-62　2018/09

    DOI： 10.1016/j.jclinane.2018.06.007 　

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    STUDY OBJECTIVE: The C-MAC laryngoscope (C-MAC) is a videolaryngoscope that uses a modified Macintosh blade. Although several anecdotal reports exist, it remains unclear whether the C-MAC is superior to the Macintosh laryngoscope for tracheal intubation in the adult population. DESIGN: Systematic review, meta-analysis. SETTING: Operating room, intensive care unit. MEASUREMENTS: For inclusion in our analysis, studies had to be prospective randomised trials which compared the C-MAC with the Macintosh laryngoscope for tracheal intubation in the adult population. Data on success rates, intubation time, glottic visualisation and incidence of external laryngeal manipulations (ELM) during tracheal intubation were extracted from the identified studies. In subgroup analysis, we separated those parameters to assess the influence of the airway condition (normal or difficult) and laryngoscopists (novice or experienced). We conducted a trial sequential analysis (TSA). MAIN RESULTS: Sixteen articles with 18 trials met the inclusion criteria. The C-MAC provided better glottic visualisation compared to the Macintosh (RR, 1.08; 95% CI, 1.03-1.14). TSA corrected the CI to 1.01-1.19; thus, total sample size reached the required information size (RIS). Success rates and intubation time did not differ significantly between the laryngoscopes. TSA showed that total sample size reached the RIS for success rates. The TSA Z curve surpassed the futility boundary. The C-MAC required less ELM compared to the Macintosh (RR, 0.83; 95% CI, 0.72-0.96). TSA corrected the CI to 0.67-1.03; 52.3% of the RIS was achieved. In difficult airways, the C-MAC showed superior success rates, glottic visualisation, and less ELM compared to the Macintosh. Among experienced laryngoscopists, the C-MAC offered better glottic visualisation with less ELM than the Macintosh. CONCLUSIONS: The C-MAC provided better glottic visualisation and less ELM (GRADE: Very Low or Moderate), with improved success rates, glottic visualisation, and less ELM in difficult airways.

  44. Airtraq® reduces the hemodynamic response to tracheal intubation using single-lumen tubes in adults compared with the Macintosh laryngoscope: A systematic review and meta-analysis of randomized control trials. International-journal Peer-reviewed

    Hiroshi Hoshijima, Koichi Maruyama, Takahiro Mihara, Tsutomu Mieda, Toshiya Shiga, Hiroshi Nagasaka

    Journal of clinical anesthesia　47　86-94　2018/06

    DOI： 10.1016/j.jclinane.2018.03.022 　

    More details Close

    STUDY OBJECTIVE: To investigate whether Airtraq® attenuate the hemodynamic responses to tracheal intubation using single-lumen tubes in adults as compared with the Macintosh laryngoscope. DESIGN: Meta-analysis. SETTING: Operating room. MEASUREMENTS: The primary outcome of this meta-analysis was to determine whether laryngoscopy using the Airtraq® reduced hemodynamic responses-heart rate (HR) and mean blood pressure (MBP)-at 60 s (s) after tracheal intubation compared to laryngoscopy with the Macintosh laryngoscope. Pooled differences in these hemodynamic responses between the two devices were expressed as weighted mean difference with 95% confidence intervals. We then conducted trial sequential analysis (TSA). The secondary outcome was to investigate whether the Airtraq® reduce the hemodynamic response at 120 s, 180 s, and 300 s after tracheal intubation compared to the Macintosh laryngoscope. We also conducted sensitivity analysis of the hemodynamic responses to tracheal intubation with the laryngoscopes using a multivariate random effects model accounting for within-study correlation of the longitudinal data. MAIN RESULTS: From electronic databases, we selected 11 randomized controlled trials for studies that enrolled subjects satisfying our inclusion criteria. Compared with the Macintosh laryngoscope, the Airtraq® significantly reduced both HR and MBP at 60 s after tracheal intubation. In secondary outcome, the Airtraq® significantly reduced both HR and MBP at all measurement points, excluding HR at 300 s after tracheal intubation. TSA showed that total sample size reached the required information size for both HR and MBP. The sensitivity analysis revealed that the Airtraq® reduced both HR and MBP at all measurement points, excluding HR at 300 s after tracheal intubation. CONCLUSIONS: The Airtraq® attenuates the hemodynamic response at 60 s after tracheal intubation compared with the Macintosh laryngoscope. (GRADE: Low) These results were supported by the sensitivity analysis. TSA suggested that the total sample size was exceeded TSA monitoring boundary both HR and MBP.

  45. McGrath videolaryngoscope versus Macintosh laryngoscope for tracheal intubation: A systematic review and meta-analysis with trial sequential analysis. International-journal Peer-reviewed

    Hiroshi Hoshijima, Takahiro Mihara, Koichi Maruyama, Yohei Denawa, Masato Takahashi, Toshiya Shiga, Hiroshi Nagasaka

    Journal of clinical anesthesia　46　25-32　2018/05

    DOI： 10.1016/j.jclinane.2017.12.030 　

    More details Close

    STUDY OBJECTIVE: The McGrath laryngoscope is a novel self-contained videolaryngoscope with a single-use blade. There are several anecdotal reports that the McGrath is superior to the Macintosh laryngoscope for tracheal intubation. However this remains controversial. DESIGN: Meta-analysis and systematic review. SETTING: Operating room or intensive care unit. MEASUREMENTS: A comprehensive literature search was conducted to identify clinical trials that met our inclusion criteria. To qualify, studies had to be prospective randomized trials comparing tracheal intubation between the McGrath and the Macintosh in an adult population. We extracted data on success rate, glottic visualization during intubation, and intubation time from the studies identified. In subgroup analysis, we assessed the influence on each of these parameters which included airway condition (normal or difficult) and operator (novice or experienced). We then conducted a trial sequential analysis (TSA). MAIN RESULTS: Fourteen articles met our inclusion criteria. The McGrath offered better glottic visualization than the Macintosh (risk ratio, 1.34; 95% confidence interval (CI), 1.25-1.45). However, the McGrath required longer intubation time (mean difference, 10.1s; CI, 2.74-17.5) and demonstrated similar success rate of tracheal intubation (risk ratio, 1.00; CI, 0.95-1.05) compared to the Macintosh. TSA showed that total sample size reached the required information size (RIS) in glottic visualization and success rate. However, only 15.1% of the RIS was achieved in intubation time. In the subgroup analysis for airway condition and operator experience level, there were no subgroup differences in both glottic visualization and intubation time. CONCLUSIONS: Our meta-analysis suggests that the McGrath is superior to the Macintosh in terms of glottic visualization (GRADE: moderate). However, it significantly extends intubation time (GRADE: very low) and its success rate (GRADE: very low) for tracheal intubation is not excellent. TSA suggests that further studies are necessary to confirm the results of intubation time.

  46. アセトアミノフェンの脊髄内投与における鎮痛機序の解明

    星島 宏, 長坂 浩, 井手 康雄, 竹内 梨紗, 西澤 秀哉

    埼玉医科大学雑誌　44　(2)　151-152　2018/03

  47. Use of sugammadex in a patient with Charcot-Marie-Tooth disease under general anesthesia Peer-reviewed

    Naoki Itoh, Hoshijima H, Takeuchi R, Nakamura C, Iwase Y, Nagasaka H, Sato T, Yoda T

    2　2-2　2018/02

  48. Videolaryngoscope versus Macintosh laryngoscope for tracheal intubation in adults with obesity: A systematic review and meta-analysis. International-journal Peer-reviewed

    Hiroshi Hoshijima, Yohei Denawa, Asako Tominaga, China Nakamura, Toshiya Shiga, Hiroshi Nagasaka

    Journal of clinical anesthesia　44　69-75　2018/02

    DOI： 10.1016/j.jclinane.2017.11.008 　

    More details Close

    STUDY OBJECTIVE: Videolaryngoscopy has become more common since the 2000s. Despite several anecdotal reports in the literature, it remains unclear whether videolaryngoscopy is superior to direct Macintosh laryngoscopy for tracheal intubation in adults with obesity. This systematic review and meta-analysis focused on prospective randomised trials comparing videolaryngoscopes with the Macintosh laryngoscope for tracheal intubation in adults with obesity. DESIGN: Systematic review, Meta-analysis SETTING: Operating room, Obesity patients MEASUREMENTS: Data on success rate, intubation time, and glottic visualisation during tracheal intubation were extracted from the identified studies. In a subgroup analysis, we also compared the parameters for videolaryngoscopes with a tracheal tube guide channel and those without a tracheal tube guide channel. Data from individual trials were combined, and the DerSimonian and Laird random-effect model was used to calculate either the pooled relative risk (RR) or the weighted mean difference (WMD) as well as the corresponding 95% confidence intervals (CI). MAIN RESULTS: Eleven articles describing 13 trials met the inclusion criteria. The performance of videolaryngoscopes was superior to that of the Macintosh laryngoscope for all outcomes. (Success rate; RR=1.11, 95% CI 1.04 to 1.18, p=0.001, I2=63%, Intubation time; WMD=-16.1, 95% CI -31.1 to -1.10, p=0.04, I2=97%, Glottic visualisation; RR=1.19, 95% CI 1.09 to 1.30, p<0.0001, I2=76%) In the subgroup analysis, the performance of both types of videolaryngoscopes (with and without a tracheal tube guide channel) was superior to that of the Macintosh laryngoscope, except for intubation time with the videolaryngoscopes without a tracheal tube guide channel. CONCLUSIONS: Videolaryngoscopes were superior to the Macintosh laryngoscope for tracheal intubation in adults with obesity. (GRADE score: low or very low.).

  49. Anesthetic Management of Reversible Cerebral Vasoconstriction Syndrome: A Case Report Peer-reviewed

    Hiroshi Hoshijima, Naoki Itoh, Yoshinori Iwase, Hiroshi Nagasaka

    Journal of Oral and Maxillofacial Surgery　75　(10)　2092-2092.e5　2017/10/01

    Publisher: W.B. Saunders

    DOI： 10.1016/j.joms.2017.06.011 　

    ISSN： 1531-5053 0278-2391

  50. Efficacy of prophylactic doses of intravenous nitroglycerin in preventing myocardial ischemia under general anesthesia: A systematic review and meta-analysis with trial sequential analysis Peer-reviewed

    Hiroshi Hoshijima, Yohei Denawa, Takahiro Mihara, Risa Takeuchi, Norifumi Kuratani, Tsutomu Mieda, Yoshinori Iwase, Toshiya Shiga, Zen'ichiro Wajima, Hiroshi Nagasaka

    JOURNAL OF CLINICAL ANESTHESIA　40　16-22　2017/08

    DOI： 10.1016/j.jclinane.2017.03.040 　

    ISSN： 0952-8180

    eISSN： 1873-4529

  51. Weekend versus weekday admission and short-term mortality A meta-analysis of 88 cohort studies including 56,934,649 participants Peer-reviewed

    Hiroshi Hoshijima, Risa Takeuchi, Takahiro Mihara, Norifumi Kuratani, Kentaro Mizuta, Zen'ichiro Wajima, Eiji Masaki, Toshiya Shiga

    MEDICINE　96　(17)　e6685-e6685　2017/04

    DOI： 10.1097/MD.0000000000006685 　

    ISSN： 0025-7974

    eISSN： 1536-5964

  52. ネットワークメタアナリシスを用いた術後シバリング予防に対する戦略

    志賀 俊哉, 輪嶋 善一郎, 星島 宏

    国際医療福祉大学学会誌　21　(抄録号)　84-84　2016/08

    Publisher: 国際医療福祉大学学会

    ISSN： 2186-3652

  53. Incidence of postoperative shivering comparing remifentanil with other opioids: a meta-analysis Peer-reviewed

    Hoshijima H, Takeuchi R, Kuratani N, Nishizawa S, Denawa Y, Shiga T, Nagasaka H

    J Clin Anesth　2016/07

  54. Effects of sniffing position for tracheal intubation: a meta-analysis of randomized controlled trials Peer-reviewed

    Yuki Akihisa, Hiroshi Hoshijima, Koichi Maruyama, Yukihide Koyama, Tomio Andoh

    AMERICAN JOURNAL OF EMERGENCY MEDICINE　33　(11)　1606-1611　2015/11

    DOI： 10.1016/j.ajem.2015.06.049 　

    ISSN： 0735-6757

    eISSN： 1532-8171

  55. ネットワーク・メタアナリシスを用いた術後シバリング予防に対する戦略

    志賀 俊哉, 輪嶋 善一郎, 星島 宏, 丹後 俊郎

    国際医療福祉大学学会誌　20　(抄録号)　63-63　2015/08

    Publisher: 国際医療福祉大学学会

    ISSN： 2186-3652

  56. Effects of sniffing position for tracheal intubation: a meta-analysis of randomised controlled trials. Peer-reviewed

    Akihisa Y, Hoshijima H, Maruyama K, Koyama Y, Andoh T

    The American Journal of Emergency Medicine　2015/03

  57. Novel identification of the free fatty acid receptor FFAR1 that promotes contraction in airway smooth muscle Peer-reviewed

    Kentaro Mizuta, Yi Zhang, Fumiko Mizuta, Hiroshi Hoshijima, Toshiya Shiga, Eiji Masaki, Charles W. Emala

    American Journal of Physiology - Lung Cellular and Molecular Physiology　309　(9)　L970-L982　2015

    Publisher: American Physiological Society

    DOI： 10.1152/ajplung.00041.2015 　

    ISSN： 1522-1504 1040-0605

  58. 脊髄性筋萎縮症III型患者の全身麻酔経験

    山本 奈央, 水田 健太郎, 星島 宏, 正木 英二

    日本歯科麻酔学会雑誌　42　(4)　521-521　2014/09

    Publisher: (一社)日本歯科麻酔学会

    ISSN： 0386-5835

    eISSN： 2433-4480

  59. チューブガイド付きビデオ硬性挿管用喉頭鏡が有用であった挿管困難の既往を持つラッセル・シルバー症候群の全身麻酔経験

    星島 宏, 水田 健太郎, 高橋 温

    障害者歯科　35　(3)　511-511　2014/09

    Publisher: (一社)日本障害者歯科学会

    ISSN： 0913-1663

    eISSN： 2188-9708

  60. The use of sugammadex in a patient with Kennedy's disease under general anesthesia Peer-reviewed

    Risa Takeuchi, Hiroshi Hoshijima, Katsushi Doi, Hiroshi Nagasaka

    Saudi Journal of Anaesthesia　8　(3)　418-420　2014

    Publisher: Medknow Publications

    DOI： 10.4103/1658-354X.136640 　

    ISSN： 0975-3125 1658-354X

  61. Pentax Airway Scope® vs Macintosh laryngoscope for tracheal intubation in adult patients: A systematic review and meta-analysis Peer-reviewed

    H. Hoshijima, N. Kuratani, Y. Hirabayashi, R. Takeuchi, T. Shiga, E. Masaki

    Anaesthesia　69　(8)　911-918　2014

    Publisher: Blackwell Publishing Ltd

    DOI： 10.1111/anae.12705 　

    ISSN： 1365-2044 0003-2409

  62. Effects of oral hygiene using chlorhexidine on preventing ventilator-associated pneumonia in critical-care settings: A meta-analysis of randomized controlled trials

    Hiroshi Hoshijima, Norifumi Kuratani, Risa Takeuchi, Toshiya Shiga, Eiji Masaki, Katsushi Doi, Nobuyuki Matsumoto

    Journal of Dental Sciences　8　(4)　348-357　2013/12

    DOI： 10.1016/j.jds.2012.11.004 　

    ISSN： 1991-7902

  63. Efficacy of Videolaryngoscopes for Nasotracheal Intubation : A Meta-analysis of Randomized Controlled Trials Peer-reviewed

    62　(11)　1375-1379　2013/11

    Publisher:

    ISSN： 0021-4892

  64. Efficacy of Glidescope Video Laryngoscope in Difficult Airways : A Meta-analysis of Randomized Controlled Trials Peer-reviewed

    62　(8)　996-1002　2013/08

    Publisher:

    ISSN： 0021-4892

  65. Effect of oral hygiene using chlorhexidine on preventing ventilator-associated pneumonia in critical care settings: a meta-analysis of randomized controlled trials Peer-reviewed

    2013/08

  66. Airtraq for Difficult Airways : A Meta-analysis of Randomized Controlled Trials Peer-reviewed

    62　(7)　879-885　2013/07

    Publisher:

    ISSN： 0021-4892

  67. Channeled Videolaryngoscope : A Meta-analysis of Randomized Controlled Trials Peer-reviewed

    62　(7)　886-893　2013/07

    Publisher:

    ISSN： 0021-4892

  68. Efficacy of Pentax-AWS in Difficult Airways : A Meta-analysis of Randomized Controlled Trials Peer-reviewed

    62　(6)　737-744　2013/06

    Publisher:

    ISSN： 0021-4892

  69. Endotracheal intubation for a neonatal patient complicated with Arnold-Chiari malformation using a pentax airway scope with a neonatal-type INTLOCK Blade (ITL-N)

    Hiroshi Hoshijima, Risa Takeuchi, Toshikatsu Imamura, Yoshinori Iwase, Hiroshi Nagasaka, Nobuyuki Matsumoto

    Japanese Journal of Anesthesiology　62　(4)　435-438　2013/04

    ISSN： 0021-4892

  70. Pentax Airway Scope新生児用イントロックが有用であったアーノルド・キアリ奇形を合併した挿管困難新生児の1症例 Peer-reviewed

    2013/01

  71. 膿胸患者に全身麻酔下で口腔外科手術をおこなった1症例 Peer-reviewed

    2013/01

  72. 水頭症による巨大頭部を合併した小児のクリッペル・トレノネー症候群の麻酔経験 Peer-reviewed

    2013/01

  73. Anesthetic management for a pediatric patient of Klippel-Trenaunay syndrome with giant head by hydrocephalus

    Hiroshi Hoshijima, Risa Takeuchi, Masanori Tsukamoto, Saori Ogawa, Yoshinori Iwase, Nobuyuki Matsumoto

    Japanese Journal of Anesthesiology　61　(12)　1356-1358　2012/12

    ISSN： 0021-4892

  74. 血液型不確定患者にO型輸血を施行した緊急手術の1症例 Peer-reviewed

    2012/01

  75. Detection of the full-length transcript variant for neurokinin-1 receptor in human whole blood associated with enhanced reinforcement of clot by substance-P Peer-reviewed

    2012/01

  76. 結節性硬化症の麻酔経験

    倉持 朗, 土井克史, 星島 宏, 菊地博達

    厚生労働科学研究費補助金難治性疾患克服研究事業 神経皮膚症候群に関する調査研究 平成22年度総括・分担研究報告書　平成22年度 総括・分担研究報告書　115-117　2011/03

  77. 頸椎骨折合併患者にAirway Scope○Rが有用であった口腔外科の1症例 Peer-reviewed

    2011/01

  78. Anesthesia Management of Takayasu Disease Complicated with Thoracic Aortic Aneurysm, Carotid Artery and Pulmonary Infarction Peer-reviewed

    TAKEUCHI Risa, HOSHIJIMA Hiroshi, IWASE Yoshinori, KIKUCHI Hirosato

    39　(1)　45-46　2011/01

    ISSN： 0386-5835

  79. Accidental skin burns by fire of an antiseptic agent ignition by the spark of electric cautery

    Hiroshi Hoshijima, Risa Takeuchi, Eiru Sato, Hirosato Kikuchi

    Japanese Journal of Anesthesiology　59　(11)　1438-1440　2010/11/10

    ISSN： 0021-4892

  80. Airway Scope○Rを用いセミファーラー位の患者に気管挿管を行った１症例 Peer-reviewed

    2010/01

  81. 小児の歯科治療における精神鎮静法実地状況 全国大学病院アンケート調査 Peer-reviewed

    2010/01

  82. 消毒薬に火花が引火した1症例 Peer-reviewed

    竹内梨紗, 佐藤栄留, 菊地博達

    麻酔　59　(11)　1438-1440　2010/01

  83. 歯科全身麻酔症例における周術期肺合併症に関する研究(原著)

    星島宏, 内田茂則, 竹内菊子, 小宅宏史, 小林克江, 大野聖加, 宮澤有美子, 小貫典子, 長谷川彰彦, 長坂浩

    明海歯科医学　38　(2)　182-187　2009/09

  84. 少量レミフェンタニル単独投与により意識下挿管を試みた１症例(短報) Peer-reviewed

    星島宏, 竹内梨紗, 塚本真規, 田草川徹, 蔵谷紀文, 中村信一, 菊地博達

    日本歯科麻酔学会誌　37　(2)　195-196　2009/07

  85. 経鼻挿管における３Dビューワー応用の可能性 Peer-reviewed

    2009/01

  86. 脊椎および硬膜外麻酔における医用3Dビューワ―応用の可能性

    2009/01

  87. Postoperative pneumonia in a patient with preoperative upper airway infection

    Yumiko Miyazawa, Masanori Tsukamoto, Takeshi Asami, Hiroshi Hoshijima, Risa Takeuchi, Noriko Onuki, Akihiko Hasegawa, Jun Shimada, Hiroshi Nagasaka

    Journal of Japanese Dental Society of Anesthesiology　35　(2)　202-205　2007

    ISSN： 0386-5835

  88. Assessment of perioperative cardiac complications in oral surgery

    Hiroshi Hoshijima, Risa Takeuchi, Noriko Onuki, Takeshi Asami, Shinichi Nakamura, Akihiko Hasegawa, Jun Shimada, Hiroshi Nagasaka

    Journal of Japanese Dental Society of Anesthesiology　35　(1)　29-35　2007

    ISSN： 0386-5835

  89. 術前上気道炎を有する患者の全身麻酔経験 Peer-reviewed

    2007/01

  90. 歯科麻酔症例における周術期心合併症危険因子に関する検討(原著) Peer-reviewed

    星島宏, 竹内梨紗, 小貫典子, 浅見剛史, 中村信一, 長谷川彰彦, 嶋田淳, 長坂浩

    日本歯科麻酔学会誌　35　(1)　29-35　2007/01

  91. 心筋梗塞の既往歴を持つ腎疾患患者の周術期管理(短報) Peer-reviewed

    星島宏, 竹内梨紗, 小貫典子, 浅見剛史, 長坂浩, 鈴木正二, 長谷川彰彦

    日本歯科麻酔学会誌　34　(3)　290-291　2006/12

  92. 専門教育前歯学部学生と臨床研修前歯科医師の蘇生に関する知識の実態 Peer-reviewed

    2006/01

  93. Induction of Non-apoptotic Cell Death by Morphinone in Human Promyelocytic Leukemia HL-60 Cells. Peer-reviewed

    2006/01

  94. Perioperative Management of a 70 year-old Patient with Acute Respiratory Failure after Prolonged Surgery of Fourteen Hours Peer-reviewed

    HOSHIJIMA Hiroshi, TAKEUCHI Risa, ONUKI Noriko, NAGASAKA Hiroshi, SUZUKI Seiji, MIYATA Yoshihiko, HASEGAWA Akihiko

    33　(1)　86-89-89　2005/01

    ISSN： 0386-5835

  95. Effect of Anticancer Agents on Codeinone- Induced Apoptosis in Human Cancer Cell Lines. Peer-reviewed

    2005/01

  96. Anesthetic management of a child with Rieger syndrome

    Risa Takeuchi, Noriko Onuki, Hiroshi Hoshijima, Hiroshi Nagasaka, Seiji Suzuki

    Journal of Japanese Dental Society of Anesthesiology　32　(3)　375-376　2004

    ISSN： 0386-5835

  97. Perioperative Management of an Elder 93 Year-old Patient with Aortic Stenosis and Ischemic Heart Disease for Right Mandibular Block Resection and Reconstruction with Plate

    Hiroshi Hoshijima, Risa Takeuchi, Noriko Onuki, Hiroshi Nagasaka, Akihiko Hasegawa, Seiji Suzuki, Hideaki Sakashita

    Journal of Japanese Dental Society of Anesthesiology　32　(2)　214-217　2004

    ISSN： 0386-5835

  98. Riger症候群小児の麻酔経験 Peer-reviewed

    2004/01

  99. 虚血性心疾患および弁疾患を有する超高齢者の全身麻酔経験(臨床報告) Peer-reviewed

    星島宏, 竹内梨紗, 小貫典子, 長坂浩, 長谷川彰彦, 鈴木正二, 坂下英明

    日本歯科麻酔学会誌　32　(2)　214-217　2004/01

Show all ︎Show first 5

Misc. 4

  1. 全身麻酔を契機に異常ヘモグロビン症と診断された小児患者の1症例

    菊地 公治, 星島 宏, 竹内 梨紗, 見崎 徹, 川合 宏仁, 山崎 信也, 阿部 将大, 岩本 潔, 峰野 友良

    日本障害者歯科学会総会および学術大会プログラム・抄録集　40回　245-245　2023/10

    Publisher: (公社)日本障害者歯科学会

  2. 当院における上下顎骨骨切り術に対する全身麻酔管理の変遷

    石川 実花, 星島 宏, 水田 健太郎

    日本歯科麻酔学会雑誌　51　(抄録号)　157-157　2023/09

    Publisher: (一社)日本歯科麻酔学会

    ISSN： 0386-5835

    eISSN： 2433-4480

  3. Questionnaire Survey Regarding Current Recognition of Deep Sedation among the Japanese Board-Certified Dental Anesthesiology Specialists and the Japanese Board of Dental Anesthesiologists

    渋谷真希子, 佐藤(朴)會士, 樋口仁, 星島宏, 森本佳成, 藤澤俊明

    日本歯科麻酔学会雑誌(Web)　48　(1)　2020

    ISSN： 2433-4480

  4. Questionnaire Survey on Deep Sedation Management at Facilities Where Dental Anesthesiologists Work

    渋谷真希子, 佐藤(朴)會士, 樋口仁, 星島宏, 森本佳成, 藤澤俊明

    日本歯科麻酔学会雑誌(Web)　47　(4)　2019

    ISSN： 2433-4480

Presentations 67

  1. 間接型喉頭鏡の有用性をメタアナリシスの視点から考える Invited

    日本歯科麻酔科学会　2022/10

  2. 人工知能を応用した術後悪心嘔吐のリスク因子の同定

    日本歯科麻酔科学会　2022/10

  3. 小児鎮静の適応とリスク Invited

    座長, 久米村正輝, 竹内護,演者, 原真理子, 山下智範, 星島宏

    日本小児麻酔学会　2021/10

  4. 歯科麻酔医は「深鎮静」をどう捉えるべきか Invited

    藤澤俊明, 森本佳成, 渋谷真希子, 佐藤曾士, 星島宏

    日本歯科麻酔科学会　2019/11

  5. AirwayScope®はMacintosh型喉頭鏡に比べ気管挿管時の循環動態の変動を抑制する；a systematic review

    星島宏, 西澤秀哉, 伊藤直樹, 相崎邦雄, 長坂浩, 菊地公治, 大野聖加, 小林克江, 牧野兼三, 髙木沙央理, 大野由夏, 小長谷光

    日本歯科麻酔科学会　2019/11

  6. Comparison of hemodynamic responses to administration of vasopressin and norepinephrine under general anesthesia: a systematic review and meta-analysis of randomized control trials

    American Society of Anesthesiologists　2019/10

  7. アセトアミノフェン類似体（D112）のマウス脊髄腔内投与における抗侵害作用の検討

    星島宏, Tony L Yaksh, 三枝勉, 井手康雄, 長坂浩

    日本ペインクリニック学会　2019/07

  8. Airtraq® と 直視型喉頭鏡での気管挿管の比較；システマチックレビュー

    星島宏, 水原敬洋, 志賀俊哉, 尾崎道郎, 納谷一郎太, 長坂浩

    日本麻酔科学会　2019/06

  9. GlideScope®は気管挿管時の心拍数，血圧の上昇を抑制しない〜Macintosh型喉頭鏡との比較；a systematic review

    星島宏, 西澤秀哉, 伊藤直樹, 高橋正人, 相崎邦雄, 長坂浩, 菊地公治, 大野聖加, 小林克江, 牧野兼三, 内田茂則, 髙木沙央理, 大野由夏, 小長谷光

    日本歯科麻酔科学会　2018/10

  10. Analgesia and abuse potential of acetaminophen and a bioisostere acetaminophen analogue in mice International-presentation

    Yaksh TL, Regen NA, Hoshijima H, Eddinger KA, Bunker KD, Hopkins CD

    Neuroscience　2018/10

  11. アセトアミノフェンは脊髄腔内投与において抗侵害作用を示さない

    Tony L Yaksh, 井手康雄, 三枝勉, 松本延幸, 長坂浩

    ペインクリニック学会　2018/07

  12. Effect of hospital and surgeon volume on mortality following major operations: umbrella review of meta-analyses of observational studies International-presentation

    Hiroshi Hoshijima, Takeshi Saito, Eisuke Takahashi, Toshiya Shiga

    European Society of Anaesthesiologists　2018/06

  13. Airtraq®はMacintosh型喉頭鏡に比べ気管挿管時の循環動態の変動を抑制する；a systematic review

    星島宏, 丸山晃一, 水原敬洋, 三枝勉, 志賀俊哉, 長坂浩

    日本麻酔学会　2018/05

  14. Conditioned pain modulationとthermal pain illusionは術後痛発症予測のバイオマーカーとなるか

    高島恵子, 大野由夏, 今村敏克, 久保英範, 松本勝洋, 松村真由美, 小宅宏史, 内田茂則, 高木沙央理, 小林克江, 牧野兼三, 西澤秀哉, 星島宏, 長坂浩, 小長谷光

    日本歯科麻酔科学会　2017/10

  15. スペシャルニーズセンターにおける全身麻酔下歯科治療の成果

    星島宏, 竹内梨紗, 長坂浩, 菊地公治, 稲川元明

    日本歯科麻酔科学会　2017/10

  16. 精神性発汗量の変動は前向性健忘効果の阻害を予測するか

    早川華穂, 高木沙沙央理, 原田達也, 松本勝洋, 高島恵子, 上杉典子, 久保英範, 松村真由美, 内田茂則, 大野由夏, 小林克江, 牧野兼三, 星島宏, 山田守正, 小長谷光

    日本歯科麻酔科学会　2017/10

  17. McGrathビデオ喉頭鏡VSマッキントッシュ型喉頭鏡：システマティクレビ

    星島宏, 竹内梨紗, 長坂浩, 菊地公治, 稲川元明

    日本歯科麻酔科学会　2017/10

  18. Aborted Case in a patient with Pheochromocytoma due to Uncontrollable Blood Pressure. International-presentation

    Denawa Y, Hoshijima H, Tokarchic B

    American Society of Anesthesiologists　2017/09

  19. アセトアミノフェンの脊髄腔内投与における抗侵害作用〜術後痛ラットモデルでの検討

    星島宏, 井手康雄, 三枝勉, 松本延幸, 長坂浩

    日本ペインクリニック学会　2017/07

  20. Glidescope vs Macintosh laryngoscope胸骨圧迫中の気管挿管の比較；systematic review

    星島宏, 丸山晃一, 三枝勉, 中村智奈, 堀越雄太, 長坂浩

    日本麻酔学会　2017/06

  21. アセトアミノフェンの脊髄腔内投与は術後痛ラットモデルで抗侵害作用を示す

    埼玉麻酔専門医会　2017/06

    More details Close

    ◎星島宏，長坂浩，井手康雄，松本延幸，三枝勉，水上智，岩瀬良範，中山英人，前山昭彦，竹内梨紗，西澤秀哉，伊藤直樹，臣永麻子，堀越雄太，中村智奈，高橋正人，野木武洋

  22. ビデオ喉頭鏡VSマッキントッシュ型喉頭鏡の気管挿管時の循環動態に対する比較

    埼玉麻酔専門医会　2016/10

  23. Bolus administration of ephedrine and etilefrine induces transient vasodilation just after injection in man International-presentation

    Europian Society of Anaesthesiologist　2016/06

  24. The effectiveness of prophylactic dose of intravenous in preventing the incidence of myocardial ischemia under general anetsthesia; A systematic review and meta-analysis International-presentation

    Europian Society of Anaesthesiologist　2016/06

  25. Prophylactic intravenous nitroglycerin dose not reduce intraoperative myocardial ischemia in surgical patients; meta-analysis International-presentation

    Takeuchi R, Hoshijima H, Nagasaka H

    Federation of Asian Dental Anesthesiology Societiesv　2015/10/03

  26. Effect of increasing depth of dexmedetomidine on hypoglossal and phrenic nerve activities in anesthetized rabbits

    薬理学会関東部会　2015/07

  27. 挿管時スニッフィングポジションの優位性におけるメタ分析

    日本麻酔科学会　2015/06

  28. Pharmacological and non-pharmacological prevention of shivering: A systematic review and Bayesian network meta-analysis of randomised clinical trials International-presentation

    Hoshijima H, Takahashi E, Imanaga K, Kuratani N, Wajima Z, Masaki E, Shiga T

    European Society of Anaesthesiologists　2015/06/01

  29. 脊髄性筋萎縮症Ⅲ型患者の全身麻酔経験

    2014/11

  30. チューブガイド付きビデオ硬性挿管用喉頭鏡が有用であった挿管困難の既往を持つラッセル・シルバー症候群の全身麻酔経験

    日本障害者歯科学会　2014/10

  31. Weekend admission, weekend operation and mortality: a systematic review, Bayesian and frequentist meta-analysis International-presentation

    European Society of Anaesthesiology　2014/06

  32. Airtraq/Airway scopeとマッキントシュ型喉頭鏡の気管挿管状態に対する比較～システマティクレビューおよびメタアナリシス～

    日本歯科麻酔学会　2013/11

  33. 週末入院患者と平日入院患者の死亡率の比較〜メタアナリシスによる検討

    Evidence-base Anesthesia 研究会　2013/11

  34. Airtraq and Pentax Airway Scope versus Macintosh laryngoscope for tracheal intubation in adults: a systematic review and meta-analysis of randomized controlled trials International-presentation

    American Society of Anesthesiologists, Sanfransisco　2013/09

  35. Remifentanil associated with increased incidence of postoperative shivering compared with fentanyl, alfentanil, and sufentanil: a meta-analysis of randomized controlled trials International-presentation

    国際歯科学会 (IADR-CED イタリア)　2013/09

  36. 東北大学病院における全身麻酔下歯科治療チームの設立と運営

    東日本歯科麻酔学会　2013/06

  37. エアウェイスコープ VS マッキントッシュ型喉頭鏡～システマティクレビューおよびメタアナリシス～

    日本歯科麻酔学会　2012/11

  38. レミフェンタニルは他の麻薬性鎮痛薬より術後のシバリングを増加させる‐メタアナリシスによる検討

    日本歯科麻酔学会　2012/11

  39. レミフェンタニルは他の麻薬性鎮痛薬より術後のシバリングを増加させる‐メタアナリシスによる検討

    Evidence-base Anesthesia 研究会　2012/11

  40. Pentax AWS/Airtraqとマッキントッシュ型喉頭鏡の気管挿管時の循環動態の変動:メタアナリシスによる検討

    Evidence-base Anesthesia 研究会　2012/11

  41. Pentax Airway Scope versus Macintosh laryngoscope for tracheal intubation in adults: a systematic review and meta-analysis of randomized controlled trials International-presentation

    American Society of Anesthesiologists, Washington D.C　2012/09

  42. Pentax Airway scope新生児用，小児用イントロックの使用経験

    埼玉麻酔医専門医会　2012/05

  43. 浅頚神経叢ブロックは甲状腺手術術後痛を軽減するか？メタアナリシスによる検討

    2011/11

  44. Pentax- Airway scope○Rとマッキントッシュ型喉頭鏡は初回気管挿管成功率に有意差はない～メタ分析による検討～

    Evidence-base Anesthesia 研究会　2011/11

  45. クロルヘキシジンを用いた口腔内洗浄は人工呼吸関連肺炎を予防する：メタアナリシスによる検討

    Evidence-base Anesthesia 研究会　2011/11

  46. Pentax AWS/Airtraqとマッキントッシュ型喉頭鏡の気管挿管時の循環動態の変動:メタアナリシスによる検討

    Evidence-base Anesthesia 研究会　2011/11

  47. Pentax- Airway scope○Rはマッキントッシュ型喉頭鏡に比べ初回気管挿管成功率を上昇させる～メタ分析による検討～

    日本歯科麻酔学会　2011/10

  48. 子供のプロポフォール麻酔はセボフルラン麻酔よりも覚醒時興奮を減少させる～メタ分析による検討～

    日本歯科麻酔学会　2011/10

  49. 水頭症による巨大頭部を合併した小児のKlippel-Trenaury症候群の麻酔経験

    埼玉麻酔医専門医会　2011/10

  50. Airway scope○R provided a higher success rate of tracheal intubation compared with the Macintosh laryngoscope in normal airway patients: a meta-analysis randomized controlled trial International-presentation

    45th. International Association for Dental Research- Continental European Division (IADR-CED).　2011/09

  51. Lower incidence of emergence agitation in pediatric patients after propofol anesthesia compared with sevoflurane: a meta-analysis of randomized controlled trials International-presentation

    45th. International Association for Dental Research- Continental European Division (IADR-CED).　2011/09

  52. クロルヘキシジンによる口腔内洗浄は人工呼吸関連肺炎を予防する

    Evidencee-base Anesthesia 研究会　2010/11

  53. 頻回のてんかん発作を伴う結節硬化症の麻酔経験

    土井克史, 菊地博達

    第50回埼玉麻酔医専門医会　2010/10

  54. Effect of oral hygiene using chlorhexidine on preventing ventilator-associated pneumonia in critical International-presentation

    Norifumi Kuratani, MD, PhD, Risa Takeuchi, DMD, PhD, Hirosato Kikuchi, MD, PhD

    第88回 国際歯科学会 (IADR)　2010/09

  55. 消毒薬に引火した1症例

    星島宏, 佐藤栄留, 竹内梨紗, 東俊晴, 岩瀬良範, 松本延幸, 菊地博達

    第48回埼玉麻酔医専門医会　2009/10

  56. Predictor of perioperative pulmonary complications of malignant tumor in oral surgery International-presentation

    H. HOSHIJIMA, R. TAKEUCHI, R. ARAKI, H. NAGASAKA, H. KIKUCHI

    国際歯科麻酔学会　2009/10

  57. 経鼻挿管における3Dビューワー応用の可能性

    星島宏, 岩瀬良範, 菊地博達

    第26回日本麻酔・集中治療テクノロジー学会　2008/12

  58. 少量レミフェンタニル投与による意識下挿管の試み

    星島宏, 岡龍弘, 竹内梨紗, 塚本真規, 蔵谷紀文, 岩瀬良範, 菊地博達

    第46回埼玉麻酔医専門医会　2008/11

  59. 頻回に麻酔経過の説明を求められた1症例

    星島宏, 竹内梨紗, 塚本真規, 蔵谷紀文, 岩瀬良範, 中村信一, 菊地博達

    日本歯科麻酔学会　2008/10

  60. 歯科口腔外科における日帰り麻酔の検討

    星島宏, 竹内梨紗, 塚本真規, 蔵谷紀文, 岩瀬良範, 中村信一

    日本歯科麻酔学会　2008/10

  61. 小児の歯科鎮静に対するアンケート調査

    星島宏, 竹内梨紗, 塚本真規, 蔵谷紀文, 菊地博達

    第45回埼玉麻酔医専門医会　2008/05

  62. 頭頚部手術の気管挿管時のビデオ喉頭鏡所見について

    竹内梨紗, 塚本真規, 中村信一, 岩瀬良範, 菊地博達

    歯科麻酔学会　2007/10

  63. 高度上気道閉塞に対してエアウェイスコープを用いアウェイク挿管し得た一症例

    星島宏, 竹内梨紗, 塚本真規, 岩瀬良範, 中村信一, 長坂浩, 菊地博達

    日本歯科麻酔学会　2007/10

  64. Assessment of Perioperative Cardiac and Pulmonary Complications in 1422 Patients in Oral Surgery International-presentation

    H. HOSHIJIMA, R.TAKEUCHI, N.ONUKI, T.ASAMI, Y.HASEGAWA, H. NAGASAKA

    国際歯科学会 (IADR)　2007/09

  65. Assessment of Perioperative Cardiac Complications in 1422 Patients in Oral Surgery International-presentation

    H. HOSHIJIMA, R.TAKEUCHI, N.ONUKI, T.ASAMI, Y.HASEGAWA, H. NAGASAKA

    国際歯科麻酔学会　2006/10

  66. Assessment of Perioperative Cardiac Complications in Oral Surgery International-presentation

    H. HOSHIJIMA, R.TAKEUCHI, N.ONUKI, T.ASAMI, H. NAGASA

    米国歯科学会 (AADR)　2006/03

  67. 口腔癌における周術期心合併症の検討

    星島宏, 竹内梨紗, 小貫典子, 浅見剛史, 長坂浩, 長谷川彰彦

    日本歯科麻酔学会　2005/10

Show all Show first 5

Research Projects 13

  1. 人工知能を応用した自動麻酔制御システムの構築

    星島 宏, 宮崎 智, 大町 真一郎, 水田 健太郎

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(C)

    Category: 基盤研究(C)

    Institution: 東北大学

    2022/04/01 - 2025/03/31

  2. Development of robotic sedation system

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)

    Category: Grant-in-Aid for Challenging Research (Exploratory)

    Institution: Tohoku University

    2021/07/09 - 2024/03/31

  3. The development of new treatment for gingival cancer considering bone resorption and cancer immunoediting

    Nakahira Mitsuhiko

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Saitama Medical University

    2017/04 - 2021/03

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    We confirmed that human gingival cancer cell line Ca9-22 cells highly expressed MICA gene and protein. DNA microarray analysis in Ca9-22 cells forced expression of MICA gene revealed that 830 genes were upregulated and 27 genes were downregulated. TRAP-positive cells were also found in immediate vicinity of Ntn4-positive vascular endothelial cells during bone healing. We performed drill-hole injury experiments and TRAP staining followed by immunostaining for PECAM-1 at day 14. We also investigated whether Ntn4 expression was changed in the serum of ovariectomized osteoporotic mice. We found that serum Ntn4 levels were significantly decreased in ovariectomized osteoporotic mice. Ntn4 may have a critical role for bone metabolism with characteristic localization.

  4. Molecular pharmacological analysis for mechanisms of action of monocytes implicating adverse effects related to autologous blood transfusion

    Azma Toshiharu, Nishioka Akira, Takenouchi Kikuko, Hoshijima Hiroshi, Nishizawa Syuya

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: National Center for Global Health and Medicine

    2016/04/01 - 2019/03/31

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    Involvement of leukocytes in adverse events related to autologous blood transfusion remain to be clarified. Flow cytometric analysis demonstrated that the incubation of human monocytic cells THP-1 at body temperature after the cold storage of these cells induced apoptosis and provoked the release of procoagulant apoptotic vesicles and microparticles with surface expression of tissue factor. Several cytokines including TNF-α, leukocyte chemotactic factors, growth factors, and Th2 cytokines appeared to be increased by such change in environmental temperature around packages of blood component without leukocyte reduction.

  5. アセトアミノフェンの鎮痛におけるセロトニン受容体（5HT）の関与についての研究

    Offer Organization: 埼玉医科大学病院

    System: 若手研究者育成研究費

    2018/09 -

  6. ビデオ喉頭鏡とマッキントシュ型喉頭鏡の循環動態の比較；メタ・アナリシスおよびシステマティックレビュー

    Offer Organization: 埼玉医科大学病院

    System: 若手研究者育成研究費

    2018/09 -

  7. 術後痛ラットモデルにおけるアセトアミノフェンの鎮痛効果および鎮痛機序の解明

    Offer Organization: 埼玉医科大学病院

    System: 若手研究者育成研究費

    2017/09 -

  8. 挿管困難患者におけるビデオ喉頭鏡とマッキントシュ型喉頭鏡の比較；メタ・アナリシスおよびシステマティックレビュー

    Offer Organization: 埼玉医科大学病院

    System: 若手研究者育成研究費

    2017/09 -

  9. Elucidation of amplification mechanisms in nociceptive signals and therapeutic strategy of intractable pain.

    Eiji Masaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2014/04/01 - 2017/03/31

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    We examined the effects of tissue-neural damage with surgical incision on the modification of primary and secondary afferent neurons in the postoperative pain model. The postoperative pain was established by plantar and infra-orbital nerve incision and the withdrawal responses along with sickness behavior were evaluated. Using the rat glabrous in vitro skin-tibial nerve preparation, afferent activities from single mechanosensitive nociceptors were recorded. 1) The microglial activation inhibitor had no effect on dorsal horn BDNF overexpression during the early post-incision period. 2) The impairment and/or modification of D2-like receptors in the spinal cord is not involved in the postoperative decrease in nociceptive threshold. 3) PAR-2-mediated excitation and sensitization of peripheral primary nociceptors was involved in the neuropathic component of postoperative pain. 4) The confidential results of hydrogen water on the postoperative pain status have not been elucidated yet.

  10. アセトアミノフェンの脊髄内投与における鎮痛機序の解明 Other

    Offer Organization: 埼玉医科大学 学内グラント

    Category: アセトアミノフェンの脊髄内投与における鎮痛機序の解明

    2016/10 -

  11. 気管挿管に関するメタ・アナリシスの応用;ビデオ喉頭鏡とマッキントシュ型喉頭鏡の比較

    Offer Organization: 埼玉医科大学病院

    System: 若手研究者育成研究費

    2016/09 -

  12. アセトアミノフェンの鎮痛における下行性抑制系伝導路の関与についての研究(

    Offer Organization: 埼玉医科大学病院

    System: 若手研究者育成研究費

    2016/09 -

  13. Effects of microparticles on monocyte-derived procoagulant activity provoked via SP : NK1R pathway

    HOSHIJIMA Hiroshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Saitama Medical University

    2010 - 2011

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    Substance-P(SP) enhances whole blood coagulation through neurokinin-1 receptors(NK1R) in leukocytes while the precise mechanisms of this phenomenon remains to be established. Thus the effects of microparticles associated with tissue factor on monocyte-derived procoagulant activity provoked via SP : NK1R pathway were evaluated. CC chemokine ligand 5(CCL5) increased microparticles released from monocytes. SP enhanced CCL5-dependent release of microparticles from these cells. Forced expression of the full-length NK1R that is not constitutively expressed in monocytes also enhanced the release of microparticles from these cells.

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