TOHOKU UNIVERSITY Researchers - Yasuyuki Shiraishi

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Yasuyuki Shiraishi

Section

Institute of Development, Aging and Cancer

Job title

Associate Professor

Degree

博士（工学）（早稲田大学）
修士（工学）（早稲田大学）

researchmap

https://researchmap.jp/y_shiraishi

J-GLOBAL ID

200901045484982017

Research History 7

2009/01 - Present

Tohoku University　Institute of Development, Aging and Cancer　Associate Professor
2004/04 - Present

Tohoku University, Institute of Development, Aging and Cancer　Assistant Professor
2002/04 - Present

Advanced Research Institute for Science and Engineering　Visiting Researcher
2002/10 - 2004/03

Japan Association for the Advancement of Medical Equipment　Postdoctral Fellow
2000/04 - 2003/03

Waseda University, Advanced Research Center for Human Science　Visiting Researcher
2002/04 - 2002/09

Waseda University, Comprehensive Research Organization　Research Associate
2000/04 - 2002/03

Waseda University, Advanced Research Institute for Science and Engineering　Research Associate

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Education 3

Waseda University　Graduate School, Division of Science and Engineering　Major in Mechanical Engineering

- 2000/03/31
Waseda University　Graduate School, Division of Science and Engineering　Major in Mechanical Engineering

- 1997/03/31
Waseda University　Faculty of Science and Engineering　Department of Mechanical Engineering

- 1995/03/31

Committee Memberships 6

International Federation for Meidlcal and Biological Engineering　Council of Societies, JSMBE

2023/06 - Present
Japanese Society for Medical and Biological Engineering　Director

2023/05 - Present
Japanese Society for Artificial Organs　評議員

2006/04 - Present
日本人工臓器学会　評議員

2006/04 - Present
International Federation for Medical and Biological Engineering　Delegate

2021/06 -
Japanese Society for Medical and Biological Engineering　Representative

2009/06 -

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Professional Memberships 9

Pediatric and Congenital Interventional Cardiovascular Society

2024/09 - Present
Japanese Society of Congenital Interventional Cardiology

2024/01 - Present
日本小児循環器学会
日本脈管学会
日本胸部外科学会
IEEE(2004/05-)
Japanese Society for Medicine and Biological Engineering(2003/04-)
The Japan Society of Mechanical Engineers(1995/07-)
Japanese Society for Artificial Organs(2006/04- )

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Research Areas 3

Life sciences / Cardiovascular surgery / Congenital cardiovascular intervention
Life sciences / Respiratory surgery / artificial organs, modelling and simulation
Life sciences / Cardiovascular surgery / artificial organs, modelling and simulation

Awards 5

Best Research Award, JSMBE Biomedical Symposium

2024/10　Japanese Society for Medical and Biological Engineering
Ogino Award - Clinical Research Application Award

2021/03　Japanese Society for Medical and Biological Engineering　Mechanisms of blood damage by mechanical circulatory system
IFMBE Asia-Pacific Traveling Fellowship

2006/08/27　IFMBE
生体医工学シンポジウムベストリサーチアワード

2005/09/27　日本生体医工学会
第31回人工心臓と補助循環懇話会研究奨励賞

2003/01/25　人工心臓と補助循環懇話会

Papers 347

New Design of an Oxygenation Cannula with a Comprehensive Set of Blood Pump

Hirotaka Sato, Kotaro Nakano, Francis Chikweto, Aoi Fukaya, Tomoyuki Yambe, Yasuyuki Shiraishi

2025

DOI： 10.1007/978-3-031-86323-3_13 　
Acute Changes in von Willebrand Factor Degradation After the Deterioration of Aortic Dissection Model in Vivo

Miharu Fukai, Yasuyuki Shiraishi, Francis Chikweto, Mayo Kobayashi, Xiaoxi Hou, Aoi Fukaya, Maiko Ikura, Kazuhiko Hanzawa, Hisanori Horiuchi, Tomoyuki Yambe

2025

DOI： 10.1007/978-3-031-80355-0_1 　
In Vitro Modelling of Aortic Dissection for Bare-Metal Stent Intervention

Mayo Kobayashi, Yasuyuki Shiraishi, Francis Chikweto, Miharu Fukai, Xiaoxi Hou, Aoi Fukaya, Maiko Ikura, Kazuhiko Hanzawa, Tomoyuki Yambe

2025

DOI： 10.1007/978-3-031-80355-0_2 　
補助人工心臓の差圧-流量変化に着目した拍内制御と心臓収縮に与える影響

八巻大祐, 田中明, 吉澤誠, 白石泰之, 山家智之

人工臓器　52　(2)　S-91　2023/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
補助人工心臓運用時の各種循環指標のカルマンフィルタを用いたオンライン推定

下川柚依, 田中明, 吉澤誠, 白石泰之, 山家智之

人工臓器　52　(2)　S-91　2023/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
超小型軸流血液ポンプ用磁性流体軸シールの高速回転下における性能評価

岡本英治, 矢野哲也, 関根一光, 井上雄介, 白石泰之, 山家智之, 三田村好矩

人工臓器　52　(2)　S-93　2023/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
機械学習による循環系の複製モデルを利用した補助人工心臓運用時の大動脈弁開閉動作のリアルタイプ推定

鈴木竜弥, 田中明, 吉澤誠, 白石泰之, 山家智之

人工臓器　52　(2)　S-167　2023/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
動物実験による冠動脈分岐部から離れた大きな瘤化を認めない弓部大動脈解離に対するベアステントの効果

榛沢和彦, 岡本竹司, 大久保由華, 白石修一, 土田正則, 白石泰之, 深谷碧, 山家智之

日本胸部外科学会定期学術集会　76回　CP17-8　2023/10
Publisher: (一社)日本胸部外科学会
補助循環時の後天性フォン・ヴィレブランド症候群を引き起こす流体剪断応答の評価システム制御系開発

深井実春, 白石泰之, Chikweto Francis, 深谷碧, Narracott Andrew, 早川正樹, 松本雅則, 堀内久徳, 山家智之

人工臓器　52　(2)　S-168　2023/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
Prediction and prevention system for Severe Acute Respiratory Syndrome CoronaVirus 2 infection by preempting the onset of a cough. International-journal

Tomoyuki Yambe, Yasuyuki Shiraishi, Akihiro Yamada, Aoi Fukaya, Genta Sahara, Makoto Yoshizawa, Norihiro Sugita

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference　2023　1-4　2023/07

DOI： 10.1109/EMBC40787.2023.10340250 　

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is fast becoming one of the most significant infections worldwide. Of all the causes of SARS-CoV-2 infection, airborne-droplet infection via coughing is the most common. Therefore, if predicting the onset of a cough and preventing infection were possible, it would have a globally positive impact. Here, we describe a new prediction and prevention system for SARS-CoV-2 infection. Usually, air is inhaled prior to coughing, and the cough, which contains droplets of the virus, then occurs during acute exhalation. Therefore, if we can predict the onset of a cough, we can prevent the spread of SARS-CoV-2. At Tohoku University, a diagnosis system for evaluating swallowing motions and peripheral circulation has already been developed, and our prediction system can be integrated into this system. Using three-dimensional human body imaging, we developed a prediction system for preempting the onset of a cough. If we can predict the onset a cough, we can prevent the spread of SARS-CoV-2 infection, by decreasing the shower of virally active airborne droplets. Here, we describe the newly developed prediction and prevention system for SARS-CoV-2 infection that preempts the onset of a cough.Clinical Relevance- If predicting the onset of a cough and preventing infection were possible, it would have a globally positive impact. Here, we describe the newly developed prediction and prevention system for SARS-CoV-2 infection.
補助人工心臓装着時の状態空間モデルを用いた循環パラメータの同定と弁の開閉動作の推定

下川柚依, 田中明, 吉澤誠, 白石泰之, 山家智之

人工臓器　52　(1)　49-49　2023/06
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
血管内設置式超小型軸流血液ポンプver2試作モデルとその性能

岡本英治, 矢野哲也, 関根一光, 井上雄介, 白石泰之, 山家智之, 三田村好矩

北海道外科雑誌　68　(1)　62-62　2023/06
Publisher: 北海道外科学会
ISSN： 0288-7509
Development and initial performance of a miniature axial flow blood pump using magnetic fluid shaft seal.

Eiji Okamoto, Tetsuya Yano, Kazumitsu Sekine, Yusuke Inoue, Yasuyuki Shiraishi, Tomoyuki Yambe, Yoshinori Mitamura

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs　26　(1)　12-16　2023/03

DOI： 10.1007/s10047-022-01330-7 　

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In this study, we developed a new catheter-mounted micro-axial flow blood pump (MFBP) using a new miniature magnetic fluid shaft seal (MFSS). The prototype of the catheter-mounted MFBP had a maximum diameter of 8 mm and a length of 50 mm. The new MFSS composed a neodymium magnet ring, an iron ring, and a magnetic fluid particularly designed for the MFSS. The new MFSS had outer and inner diameters of 4.0 mm and 2.6 mm, respectively, and a length of 3.0 mm. The sealing pressure of the MFSS was calculated to be 432 mmHg using FEM (Finite Element Method) result; therefore, the MFSS had sufficient sealing pressure for the catheter-mounted MFBP. The friction loss of the MFSS included the friction owing to the viscosity of the magnetic fluid and the magnetic force between the iron ring and ring magnet. The total friction loss of the MFSS was 0.08-0.09 W in the pump operational speed range from 22,000 to 35,000 rpm. From the in vitro experimental results, the catheter-mounted MFBP using the MFSS had a pump output of 3 L/min. against a differential pressure of 60 mmHg, and the pump characteristics of the MFBP were almost the same as those of Impella 5.0.
Prediction and prevention system for Severe Acute Respiratory Syndrome CoronaVirus 2 infection by preempting the onset of a cough

Tomoyuki Yambe, Yasuyuki Shiraishi, Akihiro Yamada, Aoi Fukaya, Genta Sahara, Makoto Yoshizawa, Norihiro Sugita

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS　2023

DOI： 10.1109/EMBC40787.2023.10340250 　

ISSN： 1557-170X
機械学習を用いた補助人工心臓運用時の大動脈弁開閉動作の推定

鈴木竜弥, 田中明, 白石泰之, 吉澤誠, 山家智之

生体医工学　Annual61　(Abstract)　217_1-217_1　2023
Publisher: 公益社団法人日本生体医工学会
DOI： 10.11239/jsmbe.annual61.217_1 　

ISSN： 1347-443X

eISSN： 1881-4379

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近年，補助人工心臓の小型化が進んだことによって，ポンプ本体の体内への植え込みが可能となり，装着しながらの社会復帰が可能となった．一方で，補助人工心臓を長期間装着することによって大動脈弁閉鎖不全症を発症するリスクが増大することが報告されている．大動脈弁閉鎖不全症は，長時間大動脈弁の開閉がないことが要因の１つであり，ポンプ出力が高い場合には弁が閉鎖しやすい．また，弁の開閉はポンプの出力だけでなく，血圧など循環状態の影響も受けることから，補助人工心臓運用中の弁の開閉状態をリアルタイムに把握することは極めて重要である．そこで本研究では，大動脈流量を直接計測せず，ポンプ流量と大動脈圧あるいはポンプ後負荷から弁の開閉を推定することを目的とした．再帰型ニューラルネットワークであるLSTMニューラルネットワークを用いて，ポンプ流量から大動脈圧あるいはポンプ後負荷までのダイナミクスを学習させ，モデルの出力誤差を利用して弁の開閉の有無を推定した．その結果，弁の開閉のないフルバイパス状態のダイナミクスを学習したモデルを用い，その推定誤差から弁の開閉動作の有無が推定できる可能性が示された．さらに，推定誤差は一拍の大動脈からの拍出量と相関しており，平均大動脈流量も推定できる可能性が示唆された．
補助人工心臓運用時におけるカルマンフィルタを用いた循環状態の推定

下川柚依, 田中明, 吉澤誠, 白石泰之, 山家智之

生体医工学　Annual61　(Abstract)　248_1-248_1　2023
Publisher: 公益社団法人日本生体医工学会
DOI： 10.11239/jsmbe.annual61.248_1 　

ISSN： 1347-443X

eISSN： 1881-4379

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補助人工心臓は循環状態に合わせて出力を変えることが望ましい．特に，弁の開閉の有無や末梢血管抵抗などをリアルタイムに把握することは，適切なポンプ出力を決定する上で重要である．しかし，循環状態を監視するために，生体に多数のセンサをつけることは望ましくなく，できだけ少なくかつ循環に影響を与えないセンサ情報のみで循環状態を表す多くのパラメータを把握することが理想的である．そこで、本研究では，ポンプ周辺の計測量であるポンプの前後負荷とポンプの流量を用い，循環の近似モデルから循環状態を推定することを目的とした．本研究では体循環系を，2要素のWindkesselモデルを基に構成した．また，これら循環系モデルをポンプ流量とポンプ前負荷を入力，ポンプ後負荷を出力とし，左心室圧，大動脈圧，大動脈流量，血管抵抗および血管のコンプライアンス等のモデルパラメータを状態変数とする状態空間モデルで表現した．また，弁抵抗は非線形関数によって表現し弁の差圧で値が変化するようにした．状態推定には，非線形システムにおいても計算可能なアンセンティッドカルマンフィルタ(UKF)を用いた．検証は，生体循環系シミュレータを内包しつつ実際のポンプを装着可能なハイブリッド模擬循環システムを用いて行った．その結果，モデルの入出力関係の推定精度が高い場合には，弁の開閉など各状態量の変化を推定できる可能性が示された．
Prediction and prevention system for Severe Acute Respiratory Syndrome CoronaVirus 2 infection by preempting the onset of a cough.

Tomoyuki Yambe, Yasuyuki Shiraishi, Akihiro Yamada, Aoi Fukaya, Genta Sahara, Makoto Yoshizawa, Norihiro Sugita

EMBC　1-4　2023

DOI： 10.1109/EMBC40787.2023.10340250 　
小口径組織工学再生人工血管(バイオチューブ)を用いたPAD患者血行再建の臨床応用に向けて

東田隆治, 中山泰秀, 宮崎真奈美, 白石泰之, 山家智之, 岩井良輔, 梅野惟史, 宮本伸二

脈管学　62　(Suppl.)　S136-S136　2022/10
Publisher: (一社)日本脈管学会
ISSN： 0387-1126

eISSN： 1880-8840
血管内設置式超小型軸流血液ポンプver2の開発と性能評価

岡本英治, 矢野哲也, 関根一光, 井上雄介, 白石泰之, 山家智之, 三田村好矩

人工臓器　51　(2)　S-137　2022/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
体外循環回路内の血栓監視システムの開発に向けた実験的検証

深谷碧, 武者詩, 白石泰之, 山田昭博, 佐原玄太, 伊藤信一郎, 野田祐資, 中野康太郎, 相澤康弘, 山家智之

人工臓器　51　(2)　S-158　2022/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
血管モデルへの接触圧力分布がモニタリング可能なカテーテルシミュレータの開発

森脇健司, 繁浦瑠偉, 山田昭博, 岡本吉弘, 白石泰之, 榛沢和彦, 山家弘雄, 藤崎和弘, 山家智之

人工臓器　51　(2)　S-217　2022/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
Von Willebrand Factorの応答を考慮したECMOシステムの臨床的評価方法に関する検討

中野康太郎, 白石泰之, 山田昭博, 深谷碧, 菅野博童, 松浦健, 早川正樹, 松本雅則, 堀内久徳, 山家智之

人工臓器　51　(2)　S-206　2022/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
磁気結合式完全埋込型拍動ポンプの経皮的駆動による血行動態評価

高地健, 山田昭博, 白石泰之, 永野友香, 山家智之

ライフサポート　34　(3)　90-95　2022/09
Publisher: (一社)ライフサポート学会
ISSN： 1341-9455
連載講座消化管領域の人工臓器開発-人工食道,人工括約筋,人工舌開発プロジェクト

山家智之, 白石泰之, 山田昭博, 深谷葵, 佐原玄太

臨床消化器内科　37　(8)　964-969　2022/07/20
Publisher: 日本メディカルセンター
DOI： 10.19020/cg.0000002278 　

ISSN： 0911-601X

eISSN： 2433-2488
In Vitro Modelling for Bulging Sinus Effects of an Expanded Polytetrafluoroethylene Valved Conduit Based on High-Speed 3D Leaflet Evaluation. International-journal

Yasuyuki Shiraishi, Andrew J Narracott, Akihiro Yamada, Aoi Fukaya, Genta Sahara, Tomoyuki Yambe, Yuka Nagano, Masaaki Yamagishi

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference　2022　4001-4004　2022/07

DOI： 10.1109/EMBC48229.2022.9871676 　

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The study aimed to develop a pulmonary circulatory system capable of high-speed 3D reconstruction of valve leaflets to elucidate the local hemodynamic characteristics in the valved conduits with bulging sinuses. Then a simultaneous measurement system for leaflet structure and pressure and flow characteristics was designed to obtain valve leaflet dynamic behaviour with different conduit structures. An image preprocessing method was established to obtain the three leaflets behaviour simultaneously for one sequence with two leaflets images from each pair of three high-speed cameras. Firstly, the multi-digital image correlation analyses were performed, and then the valve leaflet structure was measured under the static condition with fixed opening angles in the water-filled visualization chamber and the pulsatile flow tests simulating paediatric pulmonary flow conditions in the different types of conduit structures; with or without bulging sinuses. The results showed the maximum 3D reconstruction error to be around 0.06 mm. In the steady flow test, the evaluation of opening angles under the different flow rates conditions was achieved. In the pulsatile flow test, each leaflet's opening and closing behaviours were successfully reconstructed simultaneously at the high-frequency recording rate of 960fps. Therefore, the system developed in this study confirms the design evaluation method of an ePTFE valved conduit behaviour with leaflet structures interacting with local fluid dynamics in the vicinity of valves. Clinical Relevance- The system reveals the bulging sinus effects on ePTFE valve leaflet motion by the 3D reconstruction using multi-camera high-speed sequential imaging in vitro.
血液に対する剪断負荷評価のための試験システム小型化設計の試み

中地真太郎, 白石泰之, 山田昭博, 繁浦瑠偉, 永野友香, 伊藤信一郎, 野田祐資, 早川正樹, 萱島道徳, 松本雅則, 堀内久徳, 山家智之

人工臓器　51　(1)　38-38　2022/06
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
新規の磁気カップリング拍動ポンプ機構(New Magnet Coupling Pulsatile Pump Mechanism)

Takachi Ken, Shiraishi Yasuyuki, Nagano Yuka, Yamada Akihiro, Yambe Tomoyuki

ライフサポート　34　(2)　48-53　2022/06
Publisher: (一社)ライフサポート学会
ISSN： 1341-9455
Pre-implantation evaluation of a small-diameter, long vascular graft (Biotube®) for below-knee bypass surgery in goats. International-journal Peer-reviewed

Yasuhide Nakayama, Ryosuke Iwai, Takeshi Terazawa, Tsutomu Tajikawa, Tadashi Umeno, Takayuki Kawashima, Yumiko Nakashima, Yasuyuki Shiraishi, Akihiro Yamada, Ryuji Higashita, Manami Miyazaki, Tomonori Oie, Satoki Kadota, Nozomi Yabuuchi, Fumie Abe, Marina Funayama-Iwai, Tomoyuki Yambe, Shinji Miyamoto

Journal of biomedical materials research. Part B, Applied biomaterials　110　(11)　2387-2398　2022/05/13

DOI： 10.1002/jbm.b.35084 　

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There are no small-diameter, long artificial vascular grafts for below-knee bypass surgery in chronic limb-threatening ischemia. We have developed tissue-engineered vascular grafts called "Biotubes®" using a completely autologous approach called in-body tissue architecture (iBTA). This study aimed at pre-implantation evaluation of Biotube and its in vivo preparation device, Biotube Maker, for use in below-knee bypass surgery. Forty nine makers were subcutaneously embedded into 17 goats for predetermined periods (1, 2, or 3 months). All makers produced Biotubes as designed without inflammation over all periods, with the exception of a few cases with minor defects (success rate: 94%). Small hole formation occurred in only a few cases. All Biotubes obtained had an inner diameter of 4 mm and a length of 51 to 52 cm with a wall thickness of 594 ± 97 μm. All Biotubes did not kink when completely bent under an internal pressure of 100 mmHg and did not leak without any deformation under a water pressure of 200 mmHg. Their burst strength was 2409 ± 473 mmHg, and suture retention strength was 1.75 ± 0.27 N, regardless of the embedding period, whereas tensile strength increased from 7.5 ± 1.3 N at 1 month to 9.7 ± 2.0 N at 3 months with the embedding period. The amount of water leakage from the needle holes prepared in the Biotube wall was approximately 1/7th of that in expanded polytetrafluoroethylene vascular grafts. The Biotubes could be easily connected to each other without cutting or anastomosis leaks. They could be stored for at least 1 year at room temperature. This study confirmed that even Biotubes formed 1 month after embedding of Biotube Makers had properties comparable to arteries.
METHODS FOR INVESTIGATING CONTRACTION CHARACTERISTICS OF A PART OF MUSCLES FOR IMPLANTABLE POWER GENERATION SYSTEMS

Genta Sahara, Wataru Hijikata, Yusuke Inoue, Akihiro Yamada, Yasuyuki Shiraishi, Aoi Fukaya, Masato Karube, Tatsuya Genda, Naoki Iwamoto, Yuma Tachizaki, Ryosuke Morita, Tomoyuki Yambe

Journal of Mechanics in Medicine and Biology　22　(1)　2022/02/01

DOI： 10.1142/S0219519422500075 　

ISSN： 0219-5194
Chimeric mutants of staphylococcal hemolysin, which act as both one-component and two-component hemolysin, created by grafting the stem domain

Ghanem, N., Kanagami, N., Matsui, T., Takeda, K., Kaneko, J., Shiraishi, Y., Choe, C.A., Uchikubo-Kamo, T., Shirouzu, M., Hashimoto, T., Ogawa, T., Matsuura, T., Huang, P.-S., Yokoyama, T., Tanaka, Y.

FEBS Journal　2022

DOI： 10.1111/febs.16354 　

ISSN： 1742-4658 1742-464X
日本で最初の大学院医工学研究科ことはじめ

山家智之, 白石泰之, 山田昭博

生体医工学　Annual60　(Abstract)　73_1-73_1　2022
Publisher: 公益社団法人日本生体医工学会
DOI： 10.11239/jsmbe.annual60.73_1 　

ISSN： 1347-443X

eISSN： 1881-4379

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神武天皇が朝廷を開き、聖徳太子が十七条の憲法を定め「日出る処の天子」の国を整え、ペリーが襲来して維新から、科学・技術・軍事に必要性により帝国大学の制度が整えられ、１９０７年、東北帝国大学が仙台の地に設立されました。「研究第一」を掲げ、早くからＭＥ研究に着手され、私ども「抗酸菌病研究所」では、呼吸音研究の必要性から、心音図、超音波の開発に進み、世界で最初の「超音波心臓断層法」が開発されています。人工心臓研究も進み、大学病院では日本で最初の空気圧駆動補助人工心臓患者の長期生存に成功し、ＭＥ研究が患者さんの救命に直結しています。赫々たる伝統に基づき、わが国初の「大学院医工学研究科」が、東北大学に設置されました。医学の理論と、工学の理論は、全く異なります。と、言うことが判明したのは最初期の「教授会」での激論です。「医工学は工学である」「いや、そうではない」侃侃諤諤たる議論が続き、わが国でも初の試みとして「医工学研究科」の体制が整っていきました。医学系出身者にも工学系出身者にも広く門戸を開き、医学出身者には工学中心の教育、工学系出身者には医学教育を中心に、それぞれ最適な教育カリキュラムが組まれます。奨学金等も充実させ、広く人材を求めているので、国籍年齢性別に差別なく研究がすすめられ、教授よりはるかに年上の会社の社長さんの博士号などもありました。是非、一度、覗いてみてください。
Acute Phase Pilot Evaluation of Small Diameter Long iBTA Induced Vascular Graft "Biotube" in a Goat Model. International-journal Peer-reviewed

Ryuji Higashita, Yasuhide Nakayama, Yasuyuki Shiraishi, Ryosuke Iwai, Yusuke Inoue, Akihiro Yamada, Takeshi Terazawa, Tsutomu Tajikawa, Manami Miyazaki, Mamiko Ohara, Tadashi Umeno, Keitaro Okamoto, Tomonori Oie, Tomoyuki Yambe, Shinji Miyamoto

EJVES vascular forum　54　27-35　2022

DOI： 10.1016/j.ejvsvf.2022.01.004 　

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Objective: There is a need for small diameter vascular substitutes in the absence of available autologous material. A small diameter, long tissue engineered vascular graft was developed using a completely autologous approach called "in body tissue architecture technology (iBTA)". The aim of this pilot study was to evaluate "Biotubes", iBTA induced autologous collagenous tubes, for their potential use as small diameter vascular bypass conduits. Methods: Biotubes (internal diameter 4 mm, length 50 cm, wall thickness 0.85 mm) were prepared by subcutaneous embedding of plastic moulds (Biotube Maker) in three goats for approximately two months. Allogenic Biotubes (length 10 cm [n = 2], 15 cm [n = 2], 22 cm [n = 2]) were bypassed to both carotid arteries by end to side anastomosis with their ligation between the anastomoses in another three goats. Residual Biotubes were examined for their mechanical properties. After four weeks, the harvested Biotubes were evaluated histologically. Results: All Biotubes had sufficient pressure resistance, approximately 3000 mmHg. Although wall thickening occurred at two proximal anastomosis sites, all six grafts were patent without luminal thrombus formation, stenosis, or aneurysm deformation throughout the implantation period. Endothelial cells covered both anastomosis sites almost completely, with partial covering in the central portion of the grafts. Furthermore, α smooth muscle actin positive cells infiltrated the middle layer along almost the entire graft length. Conclusion: This preliminary study showed that small diameter, long, tissue engineered Biotubes could function properly as arterial bypass conduits in a large animal for one month without any abnormal change in vascular shape. Thus, small diameter, long Biotubes are potentially viable conduits, which are biocompatible and labour non-intensive, and therefore, suitable for clinical practice. Additionally, Biotubes can start the regeneration process in a short period of time.
Reflected wave intensity increases based on aortic diameter after endovascular aortic therapy in a goat model

Tomohiro Takano, Masumi Iwai-Takano, Yusuke Tsuboko, Yasuyuki Shiraishi, Tomoyuki Yambe, Takashi Igarashi, Hitoshi Yokoyama

Scientific Reports　11　(1)　2021/12
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s41598-020-80920-y 　

eISSN： 2045-2322

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<title>Abstract</title>Reflected wave increases after endovascular aortic repair (EVAR) in patients with aortic aneurysm. This affects the left ventricular (LV) diastolic function and leads to a poor prognosis. This study aimed to evaluate the relationship between increased reflected wave amplitude and aortic diameter after EVAR. EVAR was performed in seven healthy goats. We assessed wave intensity (WI), aortic diameter, and stiffness parameter β. Moreover, we evaluated the relationship between negative reflected wave (NW, reflected waves toward the heart from the periphery by WI) and other parameters after EVAR. Results showed an increase in stiffness parameter β (3.5 ± 0.3 vs 15.9 ± 4.7, <italic>p</italic> = 0.018) and a decrease in the change of aortic diameter (6.9 ± 0.7 vs 2.7 ± 0.4%, <italic>p</italic> = 0.018) after EVAR. The NW was significantly amplified after EVAR from baseline (−589.8 ± 143.4 to − 1192.3 ± 303.7 mmHg-m/sec³, <italic>p</italic> = 0.043). The NW showed a significant correlation with maximum aortic diameter (R = 0.707, <italic>p</italic> = 0.038) and minimum aortic diameter (R = 0.724, <italic>p</italic> = 0.033). The reflected wave was enhanced after EVAR and was correlated to the aortic diameter at the stent-graft site. It is important to consider that patients with smaller aortic diameters in landing zone who undergo EVAR may develop LV dysfunction.
Development of muscle connection components for implantable power generation system. International-journal

Genta Sahara, Akihiro Yamada, Yusuke Inoue, Yasuyuki Shiraishi, Wataru Hijikata, Aoi Fukaya, Tomoyuki Yambe

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference　2021　7206-7210　2021/11

DOI： 10.1109/EMBC46164.2021.9629561 　

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We have been developing an implantable power generation system that uses muscle contraction following electrical stimulation as a permanent power source for small implantable medical devices. However, if the muscle tissue is overloaded for power generation, the tissue may rupture or blood flow may be impaired. In this study, we developed a new muscle-connecting component that solves these problems. The new connection device has three rods attached to the muscle fibers, and the force exerted on the muscle fibers is converted from horizontal to vertical when the muscle contracts. We conducted simulations with a three-dimensional (3D) model, as well as pulse wave muscle measurements and in vivo tests using the actual muscle. The pulse wave in the connecting part and its downstream were optically measured from the muscle surface, and the blood flow was not obstructed. The 3D model simulations revealed that the distribution of stress was preferable compared with the case in which a rod was stuck vertically in the muscle. In the in vivo muscle tests, the metal rod and resin parts were attached to the muscle, and a load of up to approximately 9 N was applied to the connecting part. Consequently, the connecting part was stable and integrated with the muscle, and there was no damage in the muscle. Although no long-term or histological evaluations were conducted, the device may be useful because of the intramuscular power generation owing to the minimal load applied on the part connected with the muscle.
Design of an Artificial Tongue Driven by Shape Memory Alloy Fibers International-journal

Yasuyuki Shiraishi, Akihiro Yamada, Genta Sahara, Tomoyuki Yambe, Kengo Kato, Jun Ohta, Yukio Katori, Dai Homma

2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)　2021　1573-1576　2021/11/01
Publisher: IEEE
DOI： 10.1109/embc46164.2021.9630283 　

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Dysphasia is one of the complications which may cause functional disability after the surgical treatment of oral cancer. The loss of the function derived by tongue and other oral tissues impairs the retention and delivery of liquids and food masses as well as the swallowing motion into pharynx. As accumulation of liquids or food masses in the larynx can lead to pneumonia, therefore swallowing support to improve each coordination of the tongue, the epiglottis and the esophagus in the process of swallowing is highly desirable. In this study, we designed a new artificial tongue which was capable of contracting to deliver the bolus masses in the swallowing propulsion phase in the oral cavity. We designed a two-layered artificial tongue simulating the anatomical identical muscle structures with the longitudinal muscle, and the transverse muscle-genioglossus layer. A silicone rubber material was used for the surface layer, and the covalent shape memory alloy fibers (diameter: 150µm) were implemented in the secondary structure beneath of the silicone rubber material of the artificial tongue. Its contraction was driven by with shape memory alloy fibers shortage inside of the artificial tongue unit. The actuation was accurately controlled by the originally designed electrical current input with pulse width modulation. Firstly, we examined a prototype structure of the artificial tongue as well as the changes in unit thickness as it constricted by electric power supply switching. Secondly, we performed a feasibility study of the prototype into the head-neck medical training model with larynx-tracheal structure with esophagus. The results were as follows: a) the artificial tongue model showed a large contraction with a motion to increase upward pressure, b) the tongue unit expressed the capability of reducing shallow space between dorsal tongue surface and palate in the oral cavity model. Therefore, the first artificial tongue design with active contractile motion will be useful orally installable device for improving delivery function of bolus masses through swallowing procedure in dysphasia.Clinical Relevance- The active artificial tongue system designed for the first time exhibited an effective contractile motion to support bolus food masses propulsion in swallowing process in the oral cavity in the patients with dysphasia.
Design of an Artificial Tongue Driven by Shape Memory Alloy Fibers. International-journal

Yasuyuki Shiraishi, Akihiro Yamada, Genta Sahara, Tomoyuki Yambe, Kengo Kato, Jun Ohta, Yukio Katori, Dai Homma

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference　2021　1573-1576　2021/11

DOI： 10.1109/EMBC46164.2021.9630283 　

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Dysphasia is one of the complications which may cause functional disability after the surgical treatment of oral cancer. The loss of the function derived by tongue and other oral tissues impairs the retention and delivery of liquids and food masses as well as the swallowing motion into pharynx. As accumulation of liquids or food masses in the larynx can lead to pneumonia, therefore swallowing support to improve each coordination of the tongue, the epiglottis and the esophagus in the process of swallowing is highly desirable. In this study, we designed a new artificial tongue which was capable of contracting to deliver the bolus masses in the swallowing propulsion phase in the oral cavity. We designed a two-layered artificial tongue simulating the anatomical identical muscle structures with the longitudinal muscle, and the transverse muscle-genioglossus layer. A silicone rubber material was used for the surface layer, and the covalent shape memory alloy fibers (diameter: 150µm) were implemented in the secondary structure beneath of the silicone rubber material of the artificial tongue. Its contraction was driven by with shape memory alloy fibers shortage inside of the artificial tongue unit. The actuation was accurately controlled by the originally designed electrical current input with pulse width modulation. Firstly, we examined a prototype structure of the artificial tongue as well as the changes in unit thickness as it constricted by electric power supply switching. Secondly, we performed a feasibility study of the prototype into the head-neck medical training model with larynx-tracheal structure with esophagus. The results were as follows: a) the artificial tongue model showed a large contraction with a motion to increase upward pressure, b) the tongue unit expressed the capability of reducing shallow space between dorsal tongue surface and palate in the oral cavity model. Therefore, the first artificial tongue design with active contractile motion will be useful orally installable device for improving delivery function of bolus masses through swallowing procedure in dysphasia.Clinical Relevance- The active artificial tongue system designed for the first time exhibited an effective contractile motion to support bolus food masses propulsion in swallowing process in the oral cavity in the patients with dysphasia.
血液に対する剪断負荷評価のための試験システム小型化設計の試み

中地真太郎, 白石泰之, 山田昭博, 繁浦瑠偉, 永野友香, 早川正樹, 萱島道徳, 松本雅則, 堀内久徳, 山家智之

人工臓器　50　(2)　S-186　2021/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
iBTA-Induced Biotube^® Blood Vessels: 2020 Update Invited Peer-reviewed

Yasuhide Nakayama, Ryuji Higashita, Yasuyuki Shiraishi, Tadashi Umeno, Tsutomu Tajikawa, Akihiro Yamada, Kazuki Mori, Manami Miyazaki, Mamiko Ohara, Ryosuke Iwai, Takeshi Terazawa, Tomonori Oie, Tomoyuki Yambe, Shinji Miyamoto

Kidney and Dialysis　2021/06

DOI： 10.3390/kidneydial1010002 　
Hemolysis and von Willebrand factor degradation in mechanical shuttle shear flow tester.

Yasuyuki Shiraishi, Yuma Tachizaki, Yusuke Inoue, Masaki Hayakawa, Akihiro Yamada, Michinori Kayashima, Masanori Matsumoto, Hisanori Horiuchi, Tomoyuki Yambe

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs　24　(2)　111-119　2021/06

DOI： 10.1007/s10047-020-01219-3 　

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Chronic blood trauma caused by the shear stresses generated by mechanical circulatory support (MCS) systems is one of the major concerns to be considered during the development of ventricular assist devices. Large multimers with high-molecular-weight von Willebrand factor (VWF) are extended by the fluid forces in a shear flow and are cleaved by ADAMTS13. Since the mechanical revolving motions in artificial MCSs induce cleavage in large VWF multimers, nonsurgical bleeding associated with the MCS is likely to occur after mechanical hemodynamic support. In this study, the shear stress (~ 600 Pa) and exposure time related to hemolysis and VWF degradation were investigated using a newly designed mechanical shuttle shear flow tester. The device consisted of a pair of cylinders facing the test section of a small-sized pipe; both the cylinders were connected to composite mechanical heads with a sliding-sleeve structure for axial separation during the withdrawing motion. The influence of exposure time, in terms of the number of stress cycles, on hemolysis and VWF degradation was confirmed using fresh goat blood, and the differences in the rates of dissipation of the multimers were established. The plasma-free hemoglobin levels showed a logarithmic increase corresponding to the number of cycles, and the dissipation of large VWF multimers occurred within a few seconds under high shear stress flow conditions.
Development and accuracy evaluation of a degree of occlusion visualization system for roller pumps used in cardiopulmonary bypass.

Aoi Fukaya, Yasuyuki Shiraishi, Yusuke Inoue, Akihiko Yamada, Genta Sahara, Takemi Kudo, Yasuhiro Aizawa, Tomoyuki Yambe

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs　24　(1)　27-35　2021/03

DOI： 10.1007/s10047-020-01211-x 　

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In roller pumps used for cardiopulmonary bypass (CPB), the degree of blockage within the tube resulting from compression of the tube by the rollers, or the degree of occlusion, is closely related to hemolysis, with both tight occlusive and non-occlusive degrees promoting hemolysis. There are as yet no international standards regarding methods of adjusting occlusiveness, and the amount of mechanical stress exerted upon blood remains unknown. To prevent hemolysis during CPB using roller pumps, there is a need to clarify and quantitatively assess the mechanical stress of the occlusiveness of the roller pump. In this study, we have developed a degree of occlusion quantification system which constructs the flow channel shape within an occluded tube from red optical density images, and we have verified the validity of this system. Utilizing a linear actuator, an acrylic roller and raceway, a solution colored with simulated blood powder, and a 3/8-inch vinyl chloride tube, this system uses a camera to capture red optical density images within an occluded tube and constructs the tube flow channel shape using a formula manipulation system. To verify the accuracy of this system, we compared the thickness of a cross-section of the flow channel constructed with the degree of occlusion quantification system with the thickness of a cross-section of silicone cured under the same occlusion conditions. Our experiments indicated that for areas with a small tube gap, this system can construct highly accurate three-dimensional shapes and obtain quantitative indicators assessing the degree of occlusion.
Reflected wave intensity increases based on aortic diameter after endovascular aortic therapy in a goat model. International-journal

Tomohiro Takano, Masumi Iwai-Takano, Yusuke Tsuboko, Yasuyuki Shiraishi, Tomoyuki Yambe, Takashi Igarashi, Hitoshi Yokoyama

Scientific reports　11　(1)　3830-3830　2021/02/15

DOI： 10.1038/s41598-020-80920-y 　

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Reflected wave increases after endovascular aortic repair (EVAR) in patients with aortic aneurysm. This affects the left ventricular (LV) diastolic function and leads to a poor prognosis. This study aimed to evaluate the relationship between increased reflected wave amplitude and aortic diameter after EVAR. EVAR was performed in seven healthy goats. We assessed wave intensity (WI), aortic diameter, and stiffness parameter β. Moreover, we evaluated the relationship between negative reflected wave (NW, reflected waves toward the heart from the periphery by WI) and other parameters after EVAR. Results showed an increase in stiffness parameter β (3.5 ± 0.3 vs 15.9 ± 4.7, p = 0.018) and a decrease in the change of aortic diameter (6.9 ± 0.7 vs 2.7 ± 0.4%, p = 0.018) after EVAR. The NW was significantly amplified after EVAR from baseline (-589.8 ± 143.4 to - 1192.3 ± 303.7 mmHg-m/sec3, p = 0.043). The NW showed a significant correlation with maximum aortic diameter (R = 0.707, p = 0.038) and minimum aortic diameter (R = 0.724, p = 0.033). The reflected wave was enhanced after EVAR and was correlated to the aortic diameter at the stent-graft site. It is important to consider that patients with smaller aortic diameters in landing zone who undergo EVAR may develop LV dysfunction.
invention of the prediction and infection prevention system for the Cogh in SARS-COV-2

Yambe Tomoyuki, Shiraishi Yasuyuki, Yamada Akihiro, Sahara Genta

Transactions of Japanese Society for Medical and Biological Engineering　Annual59　(Abstract)　288-288　2021
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.annual59.288 　

ISSN： 1347-443X

eISSN： 1881-4379

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In this paper, the prediction and infection prevention system for the Cogh in SARS-COV-2 has been invented. By the use of the visual images of the surface of the human necks, the motion of the Cough was realized and prediction of the Cough was embodied. Active partition will prevent infection.
Effect of a Television Commercial on the Autonomic Nervous System

Tomoyuki Yambe, Yasuyuki Shiraishi, Yusuke Inoue, Akihiro Yamada, Makoto Yoshizawa

IFMBE Proceedings　77-82　2021
Publisher: Springer International Publishing
DOI： 10.1007/978-3-030-66169-4_11 　

ISSN： 1680-0737

eISSN： 1433-9277
Preliminary Study of an Objective Evaluation Method for Pulse Diagnosis using Radial Artery Pulse Measurement Device

Akihiro Yamada, Yusuke Inoue, Yasuyuki Shiraishi, Takashi Seki, Tomoyuki Yambe

Advanced Biomedical Engineering　10　113-122　2021
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.14326/abe.10.113 　

eISSN： 2187-5219
経皮的磁気伝達駆動拍動ポンプの駆出特性改善型の開発

高地健, 山田昭博, 白石泰之, 山家智之

人工臓器　49　(2)　S-174　2020/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
機械循環の高せん断によるフォンウィルブランド因子マルチマー切断に関する研究

井上雄介, 早川政樹, 山田昭博, 佐原玄太, 白石泰之, 佐藤康史, 武輪能明, 堀内久徳, 松本雅則, 山家智之

人工臓器　49　(2)　S-138　2020/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
往復動微量流体負荷剪断装置を用いたvon Willebrand因子損傷の実験的評価

白石泰之, 中地真太郎, 舘崎祐馬, 早川正樹, 萱島道徳, 山田昭博, 井上雄介, 堀内久徳, 松本雅則, 山家智之

人工臓器　49　(2)　S-175　2020/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
In vitro performance of trans-valve left ventricular assist device installed at aortic valve position. International-journal

Eiji Okamoto, Tetsuya Yano, Yusuke Inoue, Yasuyuki Shiraishi, Tomoyuki Yambe, Yoshinori Mitamura

Artificial organs　44　(10)　1067-1072　2020/10

DOI： 10.1111/aor.13687 　

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In this study, we developed a trans-valve left ventricular assist device (LVAD) that unites a rear-impeller axial-flow blood pump (AFBP) and a polymer membrane valve placed at the aortic valve position. The diameter and length of the rear impeller AFBP was 12 and 63 mm, respectively. The polymer membrane valve was similar to the jelly-fish valve consisting of a valve leaflet made of silicone rubber (thickness 0.5 mm), valve ring (diameter: 25 mm), and valve spokes. The trans-valve LVAD was examined in a mock circulation. An implantable pulsatile flow (PF) VAD was connected to an atrial reservoir to simulate the left ventricle (LV), and the Hall valve was worn in the inflow port, and the trans-valve LVAD was placed in the outflow port as an outflow valve. When the motor rotational speed increased to 26 400 rpm, the mean aortic flow increased from 4.2 to 5.3 L/min, mean aortic pressure increased from 83.4 to 100 mm Hg, and mean motor current of the implantable PF VAD decreased from 1.18 to 0.94 A (unloading effect on LV -21%). The energy equivalent pressure increased from 85.2 to 102 mm Hg, and surplus hemodynamic energy (SHE) decreased by -15.4% from the baseline. In conclusion, the trans-valve LVAD has an advantage of preserving pulsatility without any complicated mechanism and is a novel and promising LV support device.
ステントグラフト治療後の反射波増加は大動脈径に依存するヤギ実験モデルにおけるwave intensityの評価

高野智弘, 高野真澄, 坪子侑佑, 白石泰之, 山家智之, 横山斉

脈管学　60　(Suppl.)　S119-S119　2020/10
Publisher: (一社)日本脈管学会
ISSN： 0387-1126

eISSN： 1880-8840
ステントグラフト治療後の反射波増加は大動脈径に依存するヤギ実験モデルにおけるwave intensityの評価

高野智弘, 高野真澄, 坪子侑佑, 白石泰之, 山家智之, 横山斉

脈管学　60　(Suppl.)　S119-S119　2020/10
Publisher: (一社)日本脈管学会
ISSN： 0387-1126

eISSN： 1880-8840
Evaluation of the Pulse wave in the face for the patients with rotary blood pump (RP) in the Outpatient clinic

Tomoyuki Yambe, Makoto Yoshizawa, Yasuyuki Shiraishi, Yusuke Inoue, Akihiro Yamada

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS　2020-　5097-5100　2020/07/01
Publisher: Institute of Electrical and Electronics Engineers Inc.
DOI： 10.1109/EMBC44109.2020.9175425 　

ISSN： 1557-170X
Diagnosis System for Swallowing and Peristalsis Function for Artificial Tongue and Esophagus Development

Tomoyuki Yambe, Yasuyuki Shiraishi, Yusuke Inoue, Akihiro Yamada

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS　2020-　5128-5131　2020/07/01
Publisher: Institute of Electrical and Electronics Engineers Inc.
DOI： 10.1109/EMBC44109.2020.9176039 　

ISSN： 1557-170X
Modeling Approach for An Aortic Dissection with Endovascular Stenting. International-journal

Yasuyuki Shiraishi, Tomoyuki Yambe, Andrew J Narracott, Akihiro Yamada, Ryosuke Morita, Yi Qian, Kazuhiko Hanzawa

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference　2020　5008-5011　2020/07

DOI： 10.1109/EMBC44109.2020.9176423 　

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Repair of dissected aorta requires remodeling the structure of the media. Modeling approaches specific to endovascular stenting for aortic dissection have been reported. We created a goat model of descending thoracic aortic dissection and reproduced its morphological characteristics in a mock circulatory system. The purpose of this study was to examine a newly developed aortic stent which was capable of installing to the aortic dissected lesion for biomedical hemodynamics point of view. In this study, we examined the changes in hemodynamics of dissected lesions and the amelioration by endovascular stent intervention. Firstly, we performed animal experiments with the dissected aorta and examined the effects of stenting on volumetric changes in the false lumen. Secondly, we made several types of 3-D stereolithographic dissected aortic models with silicone rubber membrane between the false and the true lumens. Then, the hemodynamic characteristics in each model were evaluated in the pulsatile flow conditions in a mock circulatory system. These modelling approaches enabled the quantitative examination of post-therapeutic effects of stenting followed by elucidating of hemodynamic changes in the vicinity of stents, which may follow the management of clinical amelioration of interventional treatment with aortic stenting.Clinical Relevance- This study represents a modelling approach of the dissected aorta for endovascular intervention using stenting followed by the examination of false lumen volumetric changes resulting in the deterioration of pressure increase in diseased lesions.
微細管路系による流体剪断負荷とvon Willebrand factor損傷に関する特性評価の基礎検討

舘崎祐馬, 白石泰之, 井上雄介, 山田昭博, 岩元直樹, 盛田良介, Ibadurrahman Ahmad Faiz, 橋本真登香, 早川正樹, 萱島道徳, 松本雅則, 堀内久徳, 山家智之

人工臓器　49　(1)　37-37　2020/06
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
微細管路系による流体剪断負荷とvon Willebrand factor損傷に関する特性評価の基礎検討

舘崎祐馬, 白石泰之, 井上雄介, 山田昭博, 岩元直樹, 盛田良介, Ibadurrahman Ahmad Faiz, 橋本真登香, 早川正樹, 萱島道徳, 松本雅則, 堀内久徳, 山家智之

人工臓器　49　(1)　37-37　2020/06
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
Optimum Sterilization Methods of Biocompatible Hybrid Material for Artificial Organs Peer-reviewed

Inoue Yusuke, Shiraishi Yasuyuki, Yamada Akihiro, Yambe Tomoyuki, Abe Yusuke, Tashiro Ayaka, Kawase Yukino, Isoyama Takashi, Saito Itsuro, Ono Toshiya, Hara Shintaro, Ishii Kohei, Yurimoto Terumi

Advanced Biomedical Engineering　9　(0)　83-92　2020
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.14326/abe.9.83 　

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We previously reported the development of a new hybrid medical material comprising bio-based materials with high biocompatibility and artificial materials with characteristics of excellent strength and processability. This material shows sufficient biocompatibility and excellent stability in vivo. Moreover, when applied to the surface of an implantable sensor, the biological reaction on the sensor function surface can be well controlled. For commercialization and widespread use of hybrid materials with such superior properties, sterilization and storage are critical considerations, given that hybrid materials must be processed outside the body prior to application as medical materials in vivo, thus posing a risk of contamination despite best efforts. Therefore, the aim of the present study was to establish an optimal sterilization method that will not impair the biocompatibility of the hybrid material. Toward this end, we tested six sterilization methods for the hybrid material: autoclave (121℃, 20 min), dry heat (160℃, 120 min), ethylene oxide gas (37℃, 120 min), hydrogen peroxide plasma (45℃, 45 min), and gamma ray (25 kGy) with and without lyophilization. After sterilization, the material was cultured with vascular endothelial cells to evaluate the engraftment rate, and was observed with light and scanning electron microscopy to determine shape and structure changes. The results demonstrated that gamma sterilization without lyophilization was the best sterilization method for this material, which preserved the collagen network and showed no change in number of adhered vascular endothelial cells compared to the pre-sterilized material. These findings are useful to promote the commercialization of this hybrid material with combined advantages of synthetic and bio-based materials for widespread clinical application in the engineering of artificial organs.
Development of smart-textile for lifetime vital sensing

Inoue Yusuke, Ahmad Faiz Ibadurrahma, Hashimoto Madoka, Shiraishi Yasuyuki, Yambe Tomoyuki, Yokota Tomoyuki, Ishii Kohei, Yamada Akihiro, Iwamoto Naoki, Tachizaki Yuma, Morita Ryosuke, Sahara Genta, Fukaya Aoi

Transactions of Japanese Society for Medical and Biological Engineering　58　409-409　2020
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.Annual58.409 　

ISSN： 1347-443X

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Medical biometric information is required to be measured in a resting state or under constrained constraints. However, adverse effects on the measurement results caused by the environment at the time of measurement are implicitly accepted. A smart device that integrates these sensors with little wearing feeling into one device and can obtain biological information (pulse, electrocardiogram, body temperature distribution, body movement) that could not be measured at the same time from one clothes. Smart Textile can not only obtain measurement results without disturbance that releases the limitations of existing wearable devices, but also acquire biological information in all situations such as sleep, eating, exercise, etc.The ultimate goal is to acquire the big data of the whole living time by using the smart textile created by this research, and to develop new medical equipment and health care devices based on this information.
Evaluation of a new quantitative CPB occlusion measurement system in a mechanical squeezed model

Fukaya Aoi, Shiraishi Yasuyuki, Inoue Yusuke, Yamada Akihiro, Sahara Genta, Kudo Takemi, Aizawa Yasuhiro, Yambe Tomoyuki

Transactions of Japanese Society for Medical and Biological Engineering　58　266-266　2020
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.Annual58.266 　

ISSN： 1347-443X

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Hemolysis is one of the major blood trauma in extracorporeal circulation. The occlusion is a parameter to eliminate deteriorative blood trauma as well as to improve assisted circulation efficiency during cardiopulmonary bypass (CPB). A new occlusion simulation model was developed to evaluate the occlusion by the thickness of the flow in the tubing compressed with the CPB roller and raceway. The red-coloured densimetry images were used to calculate the thickness of occluded flow channel. In this study, we examined two types of occlusion measurements and compared the thickness of the flow in the model: a) the coloured densimetry, and b) a 3D measurement of the casted silicone. As a result, the cross-section depths showed a linear relation with the thickness lower than 120 microns. Therefore, the colour densimetry occlusion measurement model might be useful for the quantitative evaluation for CPB occlusion by the 3D reconstruction of the squeezed flow layers.
Modeling Approach for An Aortic Dissection with Endovascular Stenting

Yasuyuki Shiraishi, Tomoyuki Yambe, Andrew J. Narracott, Akihiro Yamada, Ryosuke Morita, Yi Qian, Kazuhiko Hanzawa

42ND ANNUAL INTERNATIONAL CONFERENCES OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY: ENABLING INNOVATIVE TECHNOLOGIES FOR GLOBAL HEALTHCARE EMBC'20　5008-5011　2020

ISSN： 1557-170X

eISSN： 1558-4615
Modeling Approach for An Aortic Dissection with Endovascular Stenting.

Yasuyuki Shiraishi, Tomoyuki Yambe, Andrew J. Narracott, Akihiro Yamada, Ryosuke Morita, Yi Qian, Kazuhiko Hanzawa

5008-5011　2020

DOI： 10.1109/EMBC44109.2020.9176423 　
微細管路系による流体剪断負荷とvon Willebrand factor損傷に関する特性評価の基礎検討

舘崎祐馬, 白石泰之, 井上雄介, 山田昭博, 岩元直樹, 盛田良介, Ibadurrahman Ahmad Faiz, 橋本真登香, 堀内久徳, 早川正樹, 松本雅則, 萱島道徳, 山家智之

人工臓器　48　(2)　S-241　2019/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
Development of rear-impeller axial flow blood pump for realization of axial flow blood pump installed at aortic valve position Peer-reviewed

Okamoto, E., Yano, T., Inoue, Y., Shiraishi, Y., Yambe, T., Mitamura, Y.

Artificial Organs　43　(9)　828-833　2019/09

DOI： 10.1111/aor.13476 　

ISSN： 1525-1594 0160-564X
Cloud Database Construction for the Expressway Design by the use of the Medical Information

Tomoyuki Yambe, Yasuyuki Shiraishi, Yusuke Inoue, Akihiro Yamada

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS　1448-1451　2019/07/01
Publisher: Institute of Electrical and Electronics Engineers Inc.
DOI： 10.1109/EMBC.2019.8856546 　

ISSN： 1557-170X
Emotional responses of the elderly people must be realized by the artificial intelligence

YAMBE Tomoyuki, YOSHIZAWA Makoto, INOUE Yusuke, TAMADA Akihiro, SHIRAISHI Yasuyuki

Proceedings of the Annual Conference of JSAI　JSAI2019　2N5J1302-2N5J1302　2019
Publisher: The Japanese Society for Artificial Intelligence
DOI： 10.11517/pjsai.jsai2019.0_2n5j1302 　
連続流型補助人工心臓における拍動同期時の逆流検出と完全拍動制御

伊藤光耶, 田中明, 吉澤誠, 白石泰之, 山家智之

生体医工学　Annual57　(Abstract)　S47_1-S47_1　2019
Publisher: 公益社団法人日本生体医工学会
DOI： 10.11239/jsmbe.annual57.s47_1 　

ISSN： 1347-443X

eISSN： 1881-4379

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現在，連続流型補助人工心臓の制御方法は回転数一定制御が主流となっているが，日々の生活では血液要求量が常に変化している．拍動同期制御の一つであるco-pulse制御は，収縮期に高回転，拡張期に低回転にする制御であるが，回転数が低くなる拡張期には逆流が起こりやすい．そこで本研究では，拡張期におけるポンプ流量を計測・推定せずに0L/minとする制御法の開発を目的とし，ポンプパラメータのみで逆流の検出と完全拍動制御法の開発を行った．インペラは回転数が増加する際に血液からより大きな反力を受ける．また，インペラの形状が流れ方向に対して非対称な場合，流量の正負で負荷特性が異なる．本研究では，この特性に関連する指標として，モータの回転数と電流から算出される逆流検出指標BIを提案し，流量との関係を確認した．その結果，BIは，拡張末期のポンプ流量が正と負とでその値を大きく変えた．この特性を利用した回転数制御アルゴリズムを実装したところ，拡張期にポンプ流量をほぼ0L/minに維持する完全拍動制御が実現できた．本方法は同様に軸流型ポンプにも応用できる可能性がある．
植込型人工臓器と補助循環治療における非臨床評価

白石泰之, 井上雄介, 山田昭博, 山家智之

生体医工学　Annual57　(Abstract)　S220_1-S220_1　2019
Publisher: 公益社団法人日本生体医工学会
DOI： 10.11239/jsmbe.annual57.s220_1 　

ISSN： 1347-443X

eISSN： 1881-4379

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生体医工学治療が支える少子高齢社会においては、重篤な疾患治療に対する医療機器開発応用を迅速に進めるとともに、安全性有効性に関する科学的根拠に基づく評価を非臨床で進める必要がある。東北大学加齢医学研究所非臨床試験推進センターでは、全国共同利用共同研究施設として植込み型補助人工心臓を例として長期動物実験をはじめ、生体医工学に関連する基盤技術を応用して生体適合性および血行力学的有効性の評価を行ってきている。ヒト臨床試験に先立って行われる非臨床動物試験評価では、ヒトまたは患者機能の代替とおいて動物試験が行われるが、種別による差の他にも個体差や環境要因、個々の計測誤差要因を含む収集データ精度を補償することが極めて重要である。本報告では、植込み型人工臓器と補助循環治療を例として血行動態評価に関する非臨床医工学モデリング手法と、モデリングにおけるエンティティへの種種アプローチ手法によるモダリティ評価について提示する。またあわせて一貫したデータ管理アクセスの試みについて紹介する。
Development of a blood shear stress tester for modelling of acquired von Willebrand syndrome

Yuma TACHIZAKI, Keito FUKUZAWA, Yasuyuki SHIRAISHI, Yusuke INOUE, Akihiro YAMADA, Masaki HAYAKAWA, Michinori KAYASHIMA, Masanori MATSUMOTO, Hisanori HORIUCHI, Tomoyuki YAMBE

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2019.32　1E24-1E24　2019
Publisher: Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2019.32.1e24 　

eISSN： 2424-2829
接触型ウェアラブルセンサのノイズと装着感の低減を目的とした基礎研究

井上雄介, 佐原玄太, 深谷碧, 白石泰之, 山家智之, 横田知之, 石井耕平, 山田昭博, 軽部雅人, 源田達也, 岩元直樹, 舘崎祐馬, 盛田良介

生体医工学　57　S36_2-S36_2　2019
Publisher: 公益社団法人日本生体医工学会
DOI： 10.11239/jsmbe.Annual57.S36_2 　

ISSN： 1347-443X

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医療生体情報は安静状態か拘束された制約下での計測が必須であり、計測時の環境が与える計測結果への影響は必要悪として無視されている。我々は装着感のない接触型センサを開発しており、計測による制約から解放することで外乱のない計測結果を得られるだけでなく、これまで安定計測できなかった睡眠・食事・運動時などあらゆる場面で生体情報を取得することを目的するものである。開発したシステムと既存のセンサとで生体に与えるストレス影響を循環生理学的に比較してその装着感を定量的に評価する。本研究により全生活時間のビッグデータを取得し、この情報を元に新たな医療機器・ヘルスケアデバイスを開発することが最終目標である。本発表では、3つの拠点で実施した、筋電・心電・温度・心拍を対象としたセンサの開発と装着感の評価に関する報告を行う。
人工心肺用ローラポンプ適正圧閉度の定量評価システムの構築

深谷碧, 白石泰之, 相澤康弘, 山家智之

生体医工学　57　S221_1-S221_1　2019
Publisher: 公益社団法人日本生体医工学会
DOI： 10.11239/jsmbe.Annual57.S221_1 　

ISSN： 1347-443X

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心臓手術に用いられる人工心肺装置のローラポンプは圧閉度と溶血が関係し、過度圧閉や不完全圧閉はともに溶血を引き起こす。圧閉度調整方法は日本工業規格JIS T 1603に規定されている。一方これらの指標に関しては、近年の血液適合性に関する医工学的定量評価に基づく安全性評価が重要である。臨床現場では、ローラポンプ使用前の圧閉度調整の定量性および確実性を向上させ、人工心肺装置使用時の溶血による急性腎障害を低減させることが求められており、本研究では、これらの臨床的課題に関して医工学的評価に基づく定量的な科学的根拠を示すことを目標としている。そこで、我々はマイクロフォーカスX線CT装置を用いて圧閉されるチューブの断面積を計測し、計測した断面積の形態をパラメータとして、流量特性および血液損傷を検証するための新たな圧閉度の評価システムを開発した。ローラポンプに用いられるチューブは内径や肉厚、コンプライアンスが異なる。これらローラポンプに用いられるチューブの基礎特性が及ぼす影響と構築したシステムによる圧閉度との関係について医工学的観点からのアプローチを提示する。
解離性大動脈瘤血行動態モデリングの試み

盛田良介, 山家智之, 白石泰之, 榛沢和彦, Qian Yi, Narracott Andrew, 井上雄介, 山田昭博, 岩元直樹, 舘崎祐馬

生体医工学　57　(0)　S220_2-S220_2　2019
Publisher: 公益社団法人日本生体医工学会
DOI： 10.11239/jsmbe.Annual57.S220_2 　

ISSN： 1347-443X

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【背景】解離性大動脈瘤では解離偽腔内に流入する血流がもたらす乱流による複雑な圧流量特性が観察される。治療効果と安全性を評価する上では血管内治療用の解離性大動脈瘤内の血圧血流速の医工学的モデリングが重要となっている。【目的】これまで解離性大動脈瘤の動物実験モデルを作成し血行動態の再現を行ってきた。本研究では動物実験から得られた超音波画像を基に解離性大動脈瘤血行動態のモデリングを目的としてそれらの解析手法に関して評価を進めた。【方法】〔動物解離モデル〕健常成山羊を麻酔下にて開胸し、下行大動脈の中枢側外膜を切開後、中膜を外科的に剥離し、血管開口部を切開し大動脈解離を作成した。〔モデル化手法・解析〕下行大動脈の超音波短軸像を血管長軸に沿って1mm毎の断層像とし、データの数値的再構成により形状モデルを構築した。作成したモデルを用いて模擬循環回路による流れ可視化と数値流体解析を行った。【まとめ】動物モデルでは臨床に近い形態と血流を再現できる一方、血管内治療の血行力学的評価については血流形態の差や計測誤差の課題がある。解離性大動脈瘤治療ではさまざまな医工学モデリング方法論で安全性評価が可能である。
Sophisticated hydrodynamic simulation of pulmonary circulation for the preclinical examination of right heart circulatory assist device Peer-reviewed

Yusuke Tsuboko, Yasuyuki Shiraishi, Akihiro Yamada, Kiyotaka Iwasaki, Mitsuo Umezu, Tomoyuki Yambe

IFMBE Proceedings　68　(3)　717-720　2019

DOI： 10.1007/978-981-10-9023-3_130 　

ISSN： 1680-0737
Development of Evaluation System for Von Willebrand Factor Degradation by Shear Stress of Mechanical Circulation Peer-reviewed

Yusuke Inoue, Masaki Hayakawa, Masanori Matsumoto, Hisanori Horiuchi, Yasuyuki Shiraishi, Akihiro Yamada, Masato Karube, Tatsuya Genda, Tomoyuki Yambe

40th International Engineering in Medicine and Biology Conference　40　(1)　31-31　2018/07
Modulation of the mechanical properties of ventricular extracellular matrix hydrogels with a carbodiimide crosslinker and investigation of their cellular compatibility

Fujita, K., Feng, Z., Sato, D., Kosawada, T., Nakamura, T., Shiraishi, Y., Umezu, M.

AIMS Materials Science　5　(1)　2018

DOI： 10.3934/matersci.2018.1.54 　

ISSN： 2372-0468 2372-0484
Online evaluation method of the delay of beat synchronized control for a ventricular assist device

JIMBO YUKI, TANAKA AKIRA, YOSHIZAWA MAKOTO, SHIAISHI YASUYUKI, YAMBE TOMOYUKI, MOTOMURA TADASHI

Transactions of Japanese Society for Medical and Biological Engineering　Annual56　(Abstract)　S315-S315　2018
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.annual56.s315 　

ISSN： 1347-443X

eISSN： 1881-4379

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The beat synchronized control has the advantage of ventricular unloading by increasing pump speed at systolic phase. However this advantage cannot be obtained when the timing is delayed. The aims of this study are to investigate the influence of synchronization delay on ventricular load and to propose the online evaluation method for the lag. In the case that the pump flow was obtained, it was possible to detect the time lag from systole and the instant of pump speed change. From the point of view of the pump model equations, the second order differential value of motor current has the information of the relationship between change in pump flow and speed during ramp-wise change in rotational speed. The experimental results indicated that the lag may be able to be evaluated without pump flow by using the second differential value of motor current while pump speed increased.
Pre-clinical Medical Engineering in Tohoku University

Shiraishi Yasuyuki, Yambe Tomoyuki

Transactions of Japanese Society for Medical and Biological Engineering　Annual56　(Abstract)　S27-1-S27-1　2018
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.annual56.s27-1 　

ISSN： 1347-443X

eISSN： 1881-4379

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非侵襲三次元時系列解析による世界初の食品紛体摂取時における嚥下蠕動機能の非接触定量診断

山家智之, 白石泰之

紛体工学春季発表プログラム　5　18-19　2018
Improvement of transcutaneous communication system using intra-body communication for practical use

Eiji Okamoto, Kazuhide Miura, Yasuyuki Shiraishi, Tomoyuki Yambe, Yoshinori Mitamura

Transactions of Japanese Society for Medical and Biological Engineering　56　42-43　2018
Publisher: Japan Soc. of Med. Electronics and Biol. Engineering
DOI： 10.11239/jsmbe.Annual56.42 　

ISSN： 1347-443X 1881-4379
腎神経局所冷却法による可逆的な腎神経活動制御を介した新たな高血圧治療の実験的研究 Peer-reviewed

中潟寛, 白石泰之, 弓場充, 山田昭博, 井上雄介, 山家智之

日本臨床生理学会雑誌　48　(2)　73-79　2018
摺動部洗浄水を用いる補助人工心臓の完全漏水モデルを用いた溶血実験 Peer-reviewed

平恭紀, 白石泰之, 井上雄介, 三浦英和, 山田昭博, 北野智哉, 山家智之

医工学治療　29　(3)　127-134　2017/12
Measurement of hemodynamic changes with the axial flow blood pump installed in descending aorta Peer-reviewed

Eiji Okamoto, Tetsuya Yano, Hidekazu Miura, Yasuyuki Shiraishi, Tomoyuki Yambe, Yoshinori Mitamura

JOURNAL OF ARTIFICIAL ORGANS　20　(4)　390-393　2017/12

DOI： 10.1007/s10047-017-0985-2 　

ISSN： 1434-7229

eISSN： 1619-0904
医学情報クラウドの高速道路ビッグデータ作成の知的財産が災害被害を軽減する Peer-reviewed

山家智之, 白石泰之, 井上雄介, 山田昭博

高速道路と自動車　60　(10)　37-38　2017/10
Hemodynamic examination of stent graft in goat experiment

白石泰之, 山家智之

4th Biomedical Sciences & 3rd Biomedical Engineering Symposium　3　17-18　2017
Future activity of preclinical studies in Tohoku University International-coauthorship Peer-reviewed

白石泰之, 山家智之

5th Biomedical Sciences & 4rd Biomedical Engineering Symposium　4　1-2　2017
Evaluation of adhesive reaction for percutaneou ports of implantable artificial organs International-coauthorship Peer-reviewed

白石泰之, 山家智之

4th Biomedical Sciences & 3rd Biomedical Engineering Symposium　3　19-20　2017
Simulation of various circulatory abnormalities with hybrid mock system and evaluation of control method

Oizumi Kentaro, Tnaka Akira, Yoshizawa Makoto, Shiraishi Yasuyuki, Yambe Tomoyuki, Motomura Tadashi

Transactions of Japanese Society for Medical and Biological Engineering　55　(4)　269-269　2017
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.55Annual.269 　

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A synchronized control of left ventricular assist devices has some advantages in comparison with constant rotational speed control. However, because a risk of occurrence of abnormal situation such as suction and regurgitation increase, the controller should adapt such abnormal situations. The aim of this study is to simulate the abnormal condition using hybrid-mock circulatory system combining computer simulator and mock circulatory system.Suction, regurgitation and deterioration of heart function were simulated in hybrid-mock circulatory system and the each behavior were compared with the results of animal experiments.As a result, it was confirmed that the abnormal situation simulated using the hybrid-mock circulatory system and each behavior was similar as the result of the animal experiment. Therefore, it is possible to investigate and evaluate the control algorithm using actual pump and controller.
Investigation of an effect of cannula size on assist flow and compensation by pump control

Jimbo Yuki, Tanaka Akira, Yoshizawa Makoto, Shiraishi Yasuyuki, Yambe Tomoyuki, Motomura Tadashi

Transactions of Japanese Society for Medical and Biological Engineering　55　(4)　270-270　2017
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.55Annual.270 　

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An implantable type ventricular assist device becomes mainstream, but an extracorporeal type pump has advantage in case of short term assistance. However, in the case of extracorporeal type device, it is expected that the assist flow is affected by cannula diameter and length. In this study, the influence of diameter and length of the cannula on assist flow was investigated and compensation method by pump control was proposed.The HQ curves combining cannula with pump was obtained. The model expressing HQ curve was identified from measured data and the slope of HQ curve at any drive point was evaluated. In result, although the same assist flow was actualized in small diameter by high pump speed, the slope of HQ curve around driving point became steep. Besides, the result indicated that the steepness was compensated by dynamic rotational speed control such as co-pulse mode control.
生体組織と人工材料をシームレスに接続する新しい医療材料の開発 Peer-reviewed

井上雄介, 山家智之, 白石泰之, 三浦英和, 石井耕平, 山田昭博, 阿部裕輔

東北醫學雑誌　129　(1)　52　2017
Fontan循環クリップ開発のための設計構成要素の基礎検討 Peer-reviewed

池田純平, 白石泰之, 平恭紀, 山田昭博, 井上雄介, 山岸正明, 山家智之, 本間大

東北醫學雑誌　129　(1)　100　2017
生体内組織の局所温度制御による新しい血圧コントロールの医工学的基礎検討 Peer-reviewed

弓場充, 中潟寛, 白石泰之, 坪子侑佑, 山田昭博, 井上雄介, 平恭紀, 山家智之

東北醫學雑誌　129　(1)　108　2017
食感特性評価のための嚥下挙動解析 Peer-reviewed

平恭紀, 白石泰之, 井上雄介, 山田昭博, 坪子侑佑, 池田純平, 荒川友哉, 弓場充, 山家智之

東北醫學雑誌　129　(1)　109　2017
Effect of microcirculation by total artificial heart: Observation of the blood vessels Peer-reviewed

Yusuke Inoue, Yasuyuki Shiraishi, Akihiro Yamada, Yusuke Tsuboko, Yasunori Taira, Jumpei Ikeda, Tomoya Arakawa, Mitsuru Yuba, Yusuke Abe, Takashi Isoyama, Itsuro Saito, Tomoyuki Yambe

4th Biomedical Sciences & 3rd Biomedical Engineering Symposium　3　(1)　5-6　2017
Engineering based assessment for a shape design of a pediatric ePTFE pulmonary conduit valve International-journal Peer-reviewed

Yusuke Tsuboko, Yasuyuki Shiraishi, Akihiro Yamada, Tomoyuki Yambe, Hidekazu Miura, Seitaro Mura, Masaaki Yamagishi

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS　2016-October　4313-4316　2016/10/13

DOI： 10.1109/EMBC.2016.7591681 　

ISSN： 1557-170X
Sensorless cardiac phase detection for synchronized control of ventricular assist devices using nonlinear kernel regression model Peer-reviewed

Hirohashi, Y., Tanaka, A., Yoshizawa, M., Sugita, N., Abe, M., Kato, T., Shiraishi, Y., Miura, H., Yambe, T.

Journal of Artificial Organs　19　(2)　114-120　2016/06

DOI： 10.1007/s10047-015-0880-7 　

ISSN： 1619-0904 1434-7229
The Pilot Study of Evaluating Fluctuation in the Blood Flow Volume of the Radial Artery, a Site for Traditional Pulse Diagnosis. Peer-reviewed

Watanabe M, Kaneko S, Takayama S, Shiraishi Y, Numata T, Saito N, Seki T, Sugita N, Konno S, Yambe T, Yoshizawa M, Yaegashi N, Ishii T

Medicines (Basel, Switzerland)　3　(2)　2016/05

DOI： 10.3390/medicines3020011 　
Hemodynamics of a functional centrifugal-flow total artificial heart with functional atrial contraction in goats. Peer-reviewed

Takuya Shiga, Yasuyuki Shiraishi, Kyosuke Sano, Yasunori Taira, Yusuke Tsuboko, Akihiro Yamada, Hidekazu Miura, Shintaro Katahira, Masatoshi Akiyama, Yoshikatsu Saiki, Tomoyuki Yambe

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs　19　(1)　8-13　2016/03

DOI： 10.1007/s10047-015-0852-y 　

ISSN： 1434-7229

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Implantation of a total artificial heart (TAH) is one of the therapeutic options for the treatment of patients with end-stage biventricular heart failure. There is no report on the hemodynamics of the functional centrifugal-flow TAH with functional atrial contraction (fCFTAH). We evaluated the effects of pulsatile flow by atrial contraction in acute animal models. The goats received fCFTAH that we created from two centrifugal-flow ventricular assist devices. Some hemodynamic parameters maintained acceptable levels: heart rate 115.5 ± 26.3 bpm, aortic pressure 83.5 ± 10.1 mmHg, left atrial pressure 18.0 ± 5.9 mmHg, pulmonary pressure 28.5 ± 9.7 mmHg, right atrial pressure 13.6 ± 5.2 mmHg, pump flow 4.0 ± 1.1 L/min (left) 3.9 ± 1.1 L/min (right), and cardiac index 2.13 ± 0.14 L/min/m(2). fCFTAH with atrial contraction was able to maintain the TAH circulation by forming a pulsatile flow in acute animal experiments. Taking the left and right flow rate balance using the low internal pressure loss of the VAD pumps may be easier than by other pumps having considerable internal pressure loss. We showed that the remnant atrial contraction effected the flow rate change of the centrifugal pump, and the atrial contraction waves reflected the heart rate. These results indicate that remnant atria had the possibility to preserve autonomic function in fCFTAH. We may control fCFTAH by reflecting the autonomic function, which is estimated with the flow rate change of the centrifugal pump.
高血圧治療を目的とした埋込型腎神経冷却デバイス開発の試み

白石泰之, 山家智之

Medical Engineering & Preclinical Studies　1　21-22　2016
Preliminary study for development of a new implantable nerve cooling system for hypertension

Takuji Suzuki, Yasuyuki Shiraishi, Hiroo Kumagai, Tomoyuki Yambe

Proceedings of the 12th IASTED International Conference on Biomedical Engineering, BioMed 2016　202-206　2016
Publisher: Acta Press
DOI： 10.2316/P.2016.832-040 　
食感特性評価のための嚥下挙動解析 Peer-reviewed

平恭紀, 白石泰之, 井上雄介, 山田昭博, 坪子侑佑, 池田純平, 荒川友哉, 弓場充, 駒村寛, 東條誠也, 八亀健, 山重大樹, 山家智之

第20回日本統合医療学会学術大会論文集　20　(1)　38-42　2016
脈波診断に医工学的根拠を付与する定量的評価手法の開発 Peer-reviewed

山田昭博, 坪子侑佑, 井上雄介, 平恭紀, 白石泰之, 関隆志, 山家智之

第20回日本統合医療学会学術大会論文集　20　(1)　32-37　2016
非臨床試験および前臨床試験手法を用いた心臓血管系診断に対する科学的アプローチ Peer-reviewed

井上雄介, 白石泰之, 山田昭博, 坪子侑佑, 平恭紀, 池田純平, 荒川友哉, 弓場充, 阿部裕輔, 山家智之

第20回日本統合医療学会学術大会論文集　20　(1)　26-31　2016
Development of the temperature sensor with pre-clinical research Peer-reviewed

Yusuke Inoue, Tomoyuki Yokota, Yasuyuki Shiraishi, Akihiro Yamada, Yusuke Tsuboko, Yasunori Taira, Jumpei Ikeda, Tomoya Arakawa, Mitsuru Yuba, Tomoyuki Yambe

Medical Engineering & Preclinical Studies　1　(1)　10-12　2016
Assessment of Oriental Pulse Diagnosis in a Mock Circulatory System Peer-reviewed

Dai Saito, Yuka Kobayashi, Kentaro Watanabe, Yusuke Tsuboko, Yasuyuki Shiraishi, Tomoya Arakawa, Akihiro Yamada, Yusuke Inoue, Yasunori Taira, Junpei Ikeda, Mitsuru Yuba, Tomoyuki Yambe

Medical Engineering & Preclinical Studies　2　15-16　2016
Improvement of Heat Control Device for Suppression of Renal Nerve Activity Peer-reviewed

Mitsuru Yuba, Hiroshi Nakagata, Yasuyuki Shiraishi, Yusuke Inoue, Akihiro Yamada, Yusuke Tsuboko, Yasunori Taira, Junpei Ikeda, Tomoya Arakawa, Kazumasu Sasaki, Tomoyuki Yambe

Medical Engineering & Preclinical Studies　2　12-14　2016
Effect of right atrial contraction on prosthetic valve function in a mechanical pulmonary circulatory system Peer-reviewed

Yusuke Tsuboko, Yasuyuki Shiraishi, Satoshi Matsuo, Akihiro Yamada, Hidekazu Miura, Takuya Shiga, Mohamed Omran Hashem, Tomoyuki Yambe

Journal of Biomechanical Science and Engineering　11　(3)　15-00356-15-00356　2016
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jbse.15-00356 　

ISSN： 1880-9863
Development of a thermodynamic control system for the Fontan circulation pulsation device using shape memory alloy fibers Peer-reviewed

Akihiro Yamada, Yasuyuki Shiraishi, Hidekazu Miura, Hashem Mohamed Omran Hashem, Yusuke Tsuboko, Masaaki Yamagishi, Tomoyuki Yambe

Journal of Artificial Organs　18　(3)　199-205　2015/09/04

DOI： 10.1007/s10047-015-0827-z 　

ISSN： 1434-7229

eISSN： 1619-0904
Initial Acute Animal Experiment Using a New Miniature Axial Flow Pump in Series With the Natural Heart Peer-reviewed

Eiji Okamoto, Tetsuya Yano, Yasuyuki Shiraishi, Hidekazu Miura, Tomoyuki Yambe, Yoshinori Mitamura

ARTIFICIAL ORGANS　39　(8)　701-704　2015/08

DOI： 10.1111/aor.12558 　

ISSN： 0160-564X

eISSN： 1525-1594
Fundamental analysis and development of the current and voltage control method by changing the driving frequency for the transcutaneous energy transmission system. Peer-reviewed

Miura H, Yamada A, Shiraishi Y, Yambe T

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference　2015　1319-1322　2015/08

DOI： 10.1109/EMBC.2015.7318611 　

ISSN： 1557-170X
Numerical analysis of hemodynamic changes in the left atrium due to atrial fibrillation Peer-reviewed

Koizumi, R., Funamoto, K., Hayase, T., Kanke, Y., Shibata, M., Shiraishi, Y., Yambe, T.

Journal of Biomechanics　48　(3)　472-478　2015/02

DOI： 10.1016/j.jbiomech.2014.12.025 　

ISSN： 1873-2380 0021-9290
Heartbeat detection using modeling error and beat synchronized control of rotary left ventricular assist device

HATAYA GENTA, TANAKA AKIRA, YOSHIZAWA MAKOTO, SHIRAISHI YASUYUKI, MIURA HIDEKAZU, YAMBE TOMOYUKI

Transactions of Japanese Society for Medical and Biological Engineering　53　S196_03-S196_03　2015
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.53.S196_03 　

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It is reported that a synchronized control of rotary left ventricular assist devices has some advantages in comparison with constant rotational speed control. The most common way to synchronize to heart beat is to use ECG signal because R-wave represents the beginning of systole and is easily detected. However, it is difficult to detect the onset of diastole. The aim of this study is to develop the algorithm to synchronize to heart cycle without external sensors such as ECG.In proposed method, a heartbeat was regarded as disturbance to pump rotational speed. Thus the disturbance was estimated as the difference between measured and estimated rotational speed. An ARX model which input was the reference of pump speed and current consumption was adopted to estimate the instantaneous rotational speed. The proposed method was tested in both a mock circulatory system and animal experiments. The results indicated that the system can output the heart cycle signal and detect not only the onset of systole but that of diastole. Furthermore, co-pulse and counter-pulse mode control can be demonstrated by using the detected timing. However there was detection delay at start of systole.
Detection of aortic valve opening during rotary blood pump support using support vector machine

TAKANOHASHI SHUHEI, TANAKA AKIRA, YOSHIZAWA MAKOTO, SHIRAISHI YASUYUKI, MIURA HIDEKAZU, YAMBE TOMOYUKI

Transactions of Japanese Society for Medical and Biological Engineering　53　S196_02-S196_02　2015
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.53.S196_02 　

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The left ventricular assist device(LVAD) has not only a role as the circulatory support but also as left ventricular unloading.Although high assist rate is effective for ventricular unloading,it may cause aortic flow stagnation,which may cause thrombosis or fusion of the aortic valve.Therefore,it is important to adjust a pump output corresponding to a condition of aortic valve opening.In this study,a method for detecting whether aortic valve is open has been proposed and evaluated.Support Vector Machine(SVM) of which feature variables were a rotational speed and current consumption was used for state classification.In addition,the empirical verification algorithm was applied to SVM output in order to improve sensitivity and specificity.The training and evaluation data were obtained from animal experiments using adult goats.The SVM gave a good performance when second derivative of the variables were used as features.The result indicated that the proposed algorithm have practical performance for aortic valve state detection.The information of an aortic valve state may contribute to development for automatic controller for LVAD.In future study,it is necessarily to investigate an individual difference of the parameters.
Histological observation of titanium mesh electrode for transcutaneous information transmission using human body as conductive medium

OKAMOTO EIJI, SHIDA AKANE, MIURA HIDEKAZU, SHIRAISHI YASUYUKI, YAMBE TOMOYUKI, MITAMURA YOSHINORI

Transactions of Japanese Society for Medical and Biological Engineering　53　S199_03-S199_03　2015
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.53.S199_03 　

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We have developed a transcutaneous communication system using intrabody communication, and we proposed a titanium mesh electrode to obtain mechanically and electrically stable contact with tissue by inducing surrounding tissue. In this study, we studied histocompatibility of the titanium mesh with the inner wall of the thoracic cavity using a goat. A transmission current of 6 mA with a frequency of 4 MHz is within maximum allowable current applying a human body according to the ICNIRP guideline. However, the data transmission current had an effect on the tissue inside the titanium mesh, and more numbers of inflammatory cells were induced into the titanium mesh. The titanium mesh electrode on the internal communication unit was filled with more numbers of inflammatory cells rather than the titanium mesh electrode implanted alone. Stress inside the titanium mesh due to movement of the communication unit would evoke immune reaction, and it induced inflammatory cells into the titanium mesh. While physical stimuli such as stress and current would evoke week inflammatory immune response, the titanium mesh is suitable material for an electrode that can be implanted inside the body.
Effects of blood volume on non-invasive assessment of peripheral perfusion with ventricular assist devices using a high speed CCD

SHIRAISHI YASUYUKI, Sano Kyosuke, Kitano Tomoya, Miura Hidekazu, Sasaki Kazumasa, Yambe Tomoyuki

Transactions of Japanese Society for Medical and Biological Engineering　53　S201_03-S201_03　2015
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.53.S201_03 　

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Rotary blood pumps are commonly employed as circulatory support, which might cause changes in circulation in end organs. The purpose of this study was to develop a noninvasive and contactless system for measurement of peripheral perfusion by using a high-speed camera. A measurement system was designed to derive the amplitude of the green level (AGL). The static test of colour intensity was performed in vitro to verify the blood volume density in the materials. We employed a volume density model, which consisted of a polymer sponge under the different absorption condition using fresh goat blood. The sponge with blood was sandwiched between acrylic plates and the gap between them was varied by the linear table so that the density could be evaluated. The intensity of CCD data on the top flat plate was captured and analysed. As a result, the relationship between the density of blood and the CCD intensity could be evaluated under the LED lighting conditions. Therefore, it was indicated that the AGL could be reflected by the blood volume and the system by using a high-speed camera might be useful for measuring patients' perfusion under the pump support condition.
Non Invasive Evaluation of the Renal blood flow during left ventricular assistance with the Non-pulsatile blood pump

YAMBE TOMOYUKI, SHIRAISHI YASUYUKI, MIURA HIDEKAZU

Transactions of Japanese Society for Medical and Biological Engineering　53　S128_02-S128_02　2015
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.53.S128_02 　

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Non pulsatile blood pump is one of the most important therapeutic option for the patients with profound heart failure. However, multiple organ failure has been the limiting factor for the prognosis of the patients after implantation. Non invasive measurements may be the good option to evaluate the organ function. Charge-Coupled Device image sensors will be one of the solution for the measurement with economical advantage. In this study, Charge-Coupled Device image sensors had been used for the evaluation of the renal blood flow in the animal experiments with left ventricular assistance using non pulsatile blood pump. As the results, useful evaluation of the renal blood flow had been embodied, suggesting the clinical usefulness of this device.
An Implantable Artificial Esophagus to Propel Food Simulating Natural Anatomical Esophageal Function Peer-reviewed

Yasunori Taira, Yasuyuki Shiraishi, Hidekazu Miura, Tomoyuki Yambe, Dai Homma, Kuroudo Kamiya, Go Miyata

2015 10TH ASIAN CONTROL CONFERENCE (ASCC)　2015
Contraction Support for The Right Ventricle by A Shape Memory Alloy Fibered Artificial Myocardium Peer-reviewed

Yasuyuki Shiraishi, Akihiro Yamada, Tomoyuki Yambe, Shintaro Katahira, Naoki Masaki, Yukihiro Hayatsu, Masatoshi Akiyama, Yoshikatsu Saiki, Dai Homma

2015 10TH ASIAN CONTROL CONFERENCE (ASCC)　2015
Development of Centrifugal Blood Pump for Right Ventricle of Total Artificial Heart Peer-reviewed

Hidekazu Miura, Yuki Hagio, Yusuke Inoue, Akhiro Yamada, Yusuke Tsuboko, Yasunori Taira, Kazumasu Sasaki, Yasuyuki Shiraishi, Tomoyuki Yambe

Japanese Society for Rotary Blood Pumps　23　(1)　11-14　2015
Recent progress in the study of the cardio-ankle vascular index (CAVI) Peer-reviewed

Tomoyuki Yambe, Yasuyuki Shiraishi, Hidekazu Miura, Yusuke Inoue, Yusuke Tsuboko, Akihiro Yamada, Yasunori Taira, Shota Watanabe, Yuri A Kovalev, Irina A Milyagina, Mitsuya Maruyama

Advanced Techniques in Biology & Medicine　3　(3)　1-3　2015

DOI： 10.4172/2379-1764.1000145 　
Preliminary Study on Mathematical Modeling for the Shape Design of Expanded Polytetrafluoroethylene Pulmonary Valved Conduit

Tsuboko Yusuke, Shiraishi Yasuyuki, Suzuki Ichiro, Yamada Akihiro, Miura Hidekazu, Yamagishi Masaaki, Yambe Tomoyuki

Advanced Biomedical Engineering　4　(0)　144-150　2015

DOI： 10.14326/abe.4.144 　

ISSN： 2187-5219
Effect of valsalva in the pulmonary prosthetic conduit valve on hemodynamic function in a mock circulatory system. Peer-reviewed

Yusuke Tsuboko, Yasuyuki Shiraishi, Akihiro Yamada, Tomoyuki Yambe, Satoshi Matsuo, Yoshikatsu Saiki, Masaaki Yamagishi

Conf Proc IEEE Eng Med Biol Soc　2015　278-281　2015
Publisher: IEEE
DOI： 10.1109/EMBC.2015.7318354 　

ISSN： 1557-170X
東北文化学園専門学校における生体機能代行装置学実習人工心肺実習26年間の歩み Peer-reviewed

鈴木一郎, 千葉美樹, 富田元沖, 宮本美有希, 中畑碧, 高橋るみ, 佐々木典子, 宇川雅晴, 工藤剛実, 小林峰徳, 畠山公一, 小出芳夫, 相澤康弘, 白石泰之, 山家智之, 菊地徹, 出羽仁

体外循環技術　41　(4)　505-510　2014/12
Publisher: (一社)日本体外循環技術医学会編集委員会
ISSN： 0912-2664
Preloading based needle insertion with a concave probe to enhance targeting in breast tissue Peer-reviewed

Yo Kobayashi, Maya Hatano, Makiko Suzuki, Yasuyuki Shiraishi, Tomoyuki Yambe, Makoto Hashizume, Masakatsu G Fujie

ROBOMECH Journal　1　(1)　2014/12/01
Publisher: Springer International Publishing
DOI： 10.1186/s40648-014-0017-4 　

ISSN： 2197-4225
形状記憶合金線維を応用した完全埋込型右心補助人工心筋開発設計

白石泰之, 片平, 晋太郎, 金子, 芳一, 山田, 昭博, 秋山, 正年, 齋木, 佳克, 三浦, 英和, 山家, 智之, 本間大

人工臓器　43　(2)　S-183　2014/09
Publisher:
ISSN： 0300-0818

eISSN： 1883-6097
高速動画撮影による右心系模擬循環での人工弁の挙動解析

坪子侑佑, 松尾, 諭志, 白石, 泰之, 山田, 昭博, 三浦, 英和, 平, 恭紀, 佐野, 恭介, 武良, 盛太郎, 齋木, 佳克, 山家智之

人工臓器　43　(2)　S-169　2014/09
Publisher:
ISSN： 0300-0818

eISSN： 1883-6097
小型化した遠心型補助人工心臓EVAHEARTの慢性動物実験の血液動態の評価

三浦英和, 山重, 大樹, 高崎, 映子, 白石, 泰之, 平, 恭紀, 坪子, 侑佑, 山田, 昭博, 山崎, 健二, 西中, 知博, 山田, 有希子, 片平, 晋太郎, 秋山, 正年, 齋木, 佳克, 山家智之

人工臓器　43　(2)　S-151　2014/09
Publisher:
ISSN： 0300-0818

eISSN： 1883-6097
A study on blood viscosity estimation using pulse wave signal Peer-reviewed

Tomohisa Yoshida, Norihiro Sugita, Makoto Abe, Makoto Yoshizawa, Hidekazu Miura, Yasuyuki Shiraishi, Tomoyuki Yammbe

Transactions of Japanese Society for Medical and Biological Engineering　52　389-O-391　2014/08/17
Publisher: Japan Soc. of Med. Electronics and Biol. Engineering
DOI： 10.11239/jsmbe.52.O-389 　

ISSN： 1347-443X 1881-4379
Design diversity in artificial passive-active circulatory support systems Peer-reviewed

Yasuyuki Shiraishi, Hidekazu Miura, Yusuke Tsuboko, Akihiro Yamada, Yoshikazu Kaneko, Hashem Mohamed Omran Hashem, Takuya Shiga, Shintaro Katahira, Masatoshi Akiyama, Yoshikatsu Saiki, Kiyozo Morita, Masaaki Yamagishi, Yi Qian, Tomoyuki Yambe, Dai Homma

Transactions of Japanese Society for Medical and Biological Engineering　52　OS-9　2014/08/17

DOI： 10.11239/jsmbe.52.OS-9 　

ISSN： 1881-4379

eISSN： 1347-443X
Examination of natural esophageal mechanical properties for the design of an artificial esophagus Peer-reviewed

Yasunori Taira, Kurodo Kamiya, Yasuyuki Shiraishi, Hidekazu Miura, Mohamed Omran Hashem, Akihiro Yamada, Yusuke Tsuboko, Kyosuke Sano, Dai Homma, Tomoyuki Yammbe

Transactions of Japanese Society for Medical and Biological Engineering　52　O-557　2014/08/17

DOI： 10.11239/jsmbe.52.O-557 　

ISSN： 1881-4379

eISSN： 1347-443X
Analysis of cardiovascular and autonomic nerve response to visual stress for preclinical medicine Peer-reviewed

Hidekazu Miura, Eiko Takasaki, Daiki Yamashige, Yasunori Taira, Akihiro Yamada, Yusuke Tsuboko, Kyosuke Sano, Yasuyuki Shiraishi, Tomoyuki Yambe

Transactions of Japanese Society for Medical and Biological Engineering　52　SY-25　2014/08/17

DOI： 10.11239/jsmbe.52.SY-25 　

ISSN： 1881-4379

eISSN： 1347-443X
Development of sensorless control system for pediatric pulmonary circulatory assist device using shape memory alloy fibers Peer-reviewed

Akihiro Yamada, Yasuyuki Shiraishi, Mohamed Omran Hashem, Hidekazu Miura, Yusuke Tsuboko, Tomoyuki Yambe, Dai Homma, Masaaki Yamagishi

Transactions of Japanese Society for Medical and Biological Engineering　52　O-539　2014/08/17

DOI： 10.11239/jsmbe.52.O-539 　

ISSN： 1881-4379

eISSN： 1347-443X
Measurement of the pulmonary input impedance for development of a sophisticated pulmonary vascular resistance model Peer-reviewed

Yusuke Tsuboko, Yasuyuki Shiraishi, Akihiro Yamada, Takuya Shiga, Kyosuke Sano, Tomoyuki Yambe

Transactions of Japanese Society for Medical and Biological Engineering　52　O-315　2014/08/17

DOI： 10.11239/jsmbe.52.O-315 　

ISSN： 1881-4379

eISSN： 1347-443X
Investigation of blood compatibility for cytocompatibility type a-C:H films

Ohgoe, Y., Shiraishi, Y., Miura, H., Hirdkuri, K., Fimakiibo, A., Yarrbe, T., Fiikiii, Y.

Transactions of Japanese Society for Medical and Biological Engineering　52　2014

DOI： 10.11239/jsmbe.52.O-204 　

ISSN： 1347-443X 1881-4379
Preliminary study on contactless evaluation of peripheral perfusion during rotary blood pump support Peer-reviewed

Kyosuke Sano, T. Kitano, Y. Shiraishi, A. Tanaka, M. Yoshizawa, T. Yambe

IFMBE Proceedings　43　444-447　2014
Publisher: Springer Verlag
DOI： 10.1007/978-3-319-02913-9_113 　

ISSN： 1680-0737
Examintion of the transcutaneous transmission system with the internal energy storage system for artificial organs using shape memory alloy fiber

Miura Hidekazu, Yamada Akihiro, Hashem Mohamed Omran, Shiraishi Yasuyuki, Sato Fumihiro, Yambe Tomoyuki, Matsuki Hidetoshi

BME　52　O-98-O-99　2014
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.52.O-98 　

ISSN： 1347-443X

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Artificial organs using shape memory (SMA) fibers have possibilities to achieve small size and simple control. However, there was a problem of the instant heavy load; we proposed an efficient transcutaneous energy transmission system with internal energy storage circuit for SMA fibered devices.In this system, the internal storage capacitor was charged slowly while the fibers are turned off and discharge the energy when the fibers are turned on. We examined the effect of the system. Firstly we changed capacitance from 500uF to 34100uF. Secondly we changed the input current limitation. With largest capacitance, the device could be driven,however with smallest capacitance devece did not worked.With the cuurent limitattion,the input current was reduced to 0.5A. It was found that the size and maximum output of the TETS would able to be reduced and drive the SMA fibers efficiently.
The Effect of Control Condition of Ventricular Assist Device on the Response of Cardiac Output to Venous Blood Return

Taniguchi Satomi, Tanaka Akira, Yoshizawa Makoto, Shiraishi Yasuyuki, Miura Hidekazu, Kitano Tomoya, Yambe Tomoyuki

BME　52　O-546-O-547　2014
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.52.O-546 　

ISSN： 1347-443X

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The cardiac functions including the autoregulation such as Frank-Starling preload response is depressed in heart failure. Although ventricular assist device (VAD) contributes to reduce ventricular load and increase cardiac output, the effect of VAD on depressed preload response has not become clear. In this study, the effect of control conditions and performance curve of blood pump on the preload sensitivity was investigated using numerical simulations. The preload sensitivity was defined as maximum change in cardiac output when right atrial pressure was changed from circulatory equilibrium in the simulations. Furthermore, animal experiment was performed in order to verify the result of the simulations. The preload sensitivity of pump flow changed depending on pump characteristic. Conversely, that of total flow was almost the same with various pump characteristics at partial bypass condition. Results indicated that it is necessary to introduce some active control to improve the sensitivity.
Preliminary examination of peripheral resistance in kidney by using a high-speed CCD

Sano Kyosuke, Kitano Tomoya, Shiraishi Yasuyuki, Miura Hidekazu, Tanaka Akira, Yoshizawa Makoto, Yambe Tomoyuki

BME　52　O-311-O-312　2014
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.52.O-311 　

ISSN： 1347-443X

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Pulsatility in aortic flow can be obtained with native ventricles even if the assist devices are rotary blood flow types. Therefore, it is anticipated that the pulsatile flow with centrifugal blood pumps might cause changes in peripheral perfusions. We have been establishing a new method of measuring peripheral perfusions by using a high speed CCD camera in order to diagnose blood flow in peripheral organs.In this study, we performed an animal experiment using a goat and examined renal circulation under the administration of vasodilator with two different types of blood flow measurements; a laser Doppler tissue flow and the CCD. We also compared the peripheral impedance in each method as well as the renal input impedance calculated by the aortic pressure and electromagnetic flow waveforms. As a result, the longitudinal and characteristic impedance data decreased under the vasodilation condition in each renal peripheral perfusion analysis.
Achievement of peristaltic design in the artificial esophagus based on esophageal characteristic analysis of goats’ specimen Peer-reviewed

Yasunori Taira, K. Kamiya, Y. Shiraishi, H. Miura, T. Shiga, M. O. Hashem, A. Yamada, Y. Tsuboko, T. Ito, K. Sano, D. Homma, T. Yambe

IFMBE Proceedings　43　372-374　2014

DOI： 10.1007/978-3-319-02913-9_95 　

ISSN： 1680-0737
Design of a right ventricular simulator for the evaluation of artificial pulmonary valve Peer-reviewed

Yusuke Tsuboko, S. Matsuo, Y. Shiraishi, H. Miura, A. Yamada, M. O. Hashem, T. Ito, K. Sano, Y. Taira, T. Akutsu, Z. Feng, M. Umezu, M. Yamagishi, Y. Saiki, T. Yambe

IFMBE Proceedings　43　440-443　2014

DOI： 10.1007/978-3-319-02913-9_112 　

ISSN： 1680-0737
Improvement of a shape memory alloy fibered aortic pulsation device Peer-reviewed

Mohamed O. Hashem, Y. Shiraishi, A. Yamada, Y. Tsuboko, H. Muira, T. Yambe, D. Homma

IFMBE Proceedings　43　399-402　2014

DOI： 10.1007/978-3-319-02913-9_102 　

ISSN： 1680-0737
Modeling of signal transmissions in nerves in vitro for the development of a renal nerve cooling device for hypertension control Peer-reviewed

Takuya Ito, H. Miura, T. Shiga, M. O. Hashem, K. Kamiya, A. Yamada, Y. Tsuboko, K. Sano, Y. Taira, Y. Shiraishi, H. Kumagai, T. Yambe

IFMBE Proceedings　43　448-451　2014

DOI： 10.1007/978-3-319-02913-9_114 　

ISSN： 1680-0737
Discrimination Ability and Reproducibility of a New Index Reflecting Autonomic Nervous Function Based on Pulsatile Amplitude of Photoplethysmography Peer-reviewed

Yusuke Kano, Makoto Yoshizawa, Norihiro Sugita, Makoto Abe, Noriyasu Homma, Akira Tanaka, Tsuyoshi Yamauchi, Hidekazu Miura, Yasuyuki Shiraishi, Tomoyuki Yambe

2014 36TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　2014　1794-1800　2014

DOI： 10.1109/EMBC.2014.6943957 　

ISSN： 1557-170X
Preliminary validation of a new magnetic wireless blood pump Peer-reviewed

Sung Hoon Kim, Kazushi Ishiyama, Shuichiro Hashi, Yasuyuki Shiraishi, Yukihiro Hayatsu, Masatoshi Akiyama, Yoshikatsu Saiki, Tomoyuki Yambe

Artificial Organs　37　(10)　920-926　2013/10

DOI： 10.1111/aor.12093 　

ISSN： 0160-564X 1525-1594
Telemedicine with Electric Doctor's Bag and the quantitative evaluation of the radial pulse wave to prevent cardiovascular event in Sendai Quake Peer-reviewed

Tomoyuki Yambe, Muneichi Shibata, Hidekazu Miura, Makoto Yoshizawa, Yasuyuki Shiraishi, Norihiro Sugita

Proc. of the IEEE Region 10 Humanitarian Technology Conference　47-52　2013/08/26

DOI： 10.1109/R10-HTC.2013.6669012 　
Expansion capsules for diet control with artificial organ technology Peer-reviewed

Tomoyuki Yambe, Yasuyuki Shiraishi, Hidekazu Miura, Norihiro Sugita, Makoto Yoshizawa

Proc. of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society　5739-5742　2013/07/03

DOI： 10.1109/EMBC.2013.6610854 　
Enhancement of Hemocompatibility of the MERA Monopivot Centrifugal Pump: Toward Medium-Term Use Peer-reviewed

Takashi Yamane, Ryo Kosaka, Masahiro Nishida, Osamu Maruyama, Yoshihiro Yamamoto, Katsuyuki Kuwana, Hiroshi Kawamura, Yasuyuki Shiraishi, Tomoyuki Yambe, Yoshiyuki Sankai, Tatsuo Tsutsui

Artificial Organs　37　(2)　217-221　2013/02

DOI： 10.1111/j.1525-1594.2012.01530.x 　

ISSN： 0160-564X 1525-1594
Preliminary design of the mechanical circulation assist device for Fontan circulation using shape memory alloy fibers Peer-reviewed

A. Yamada, Y. Shiraishi, T. K. Sugai, H. Miura, T. Shiga, M. O. Hashem, C. Koga, H. Hashimoto, Y. Tsuboko, T. Yambe, M. Yamagishi, D. Homma

IFMBE Proceedings　39 IFMBE　119-121　2013

DOI： 10.1007/978-3-642-29305-4_33 　

ISSN： 1680-0737
Controlling methods of a newly developed extra aortic counter-pulsation device using shape memory alloy fibers Peer-reviewed

Mohamed O. Hashem, A. Yamada, Y. Tsuboko, H. Muira, D. Homma, Y. Shiraishi, T. Yambe

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS　2013　2740-2743　2013
Publisher: IEEE
DOI： 10.1109/EMBC.2013.6610107 　

ISSN： 1557-170X
Peristaltic hemodynamics of a new pediatric circulatory assist system for Fontan circulation using shape memory alloy fibers Peer-reviewed

A. Yamada, Y. Shiraishi, H. Miura, T. Yambe, M. H. Omran, T. Shiga, Y. Tsuboko, D. Homma, M. Yamagishi

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS　2013　683-686　2013
Publisher: IEEE
DOI： 10.1109/EMBC.2013.6609592 　

ISSN： 1557-170X
Hemodynamic effects of pressure-volume relation in the atrial contraction model on the total artificial heart using centrifugal blood pumps International-journal Peer-reviewed

Takuya Shiga, Takehito Kuroda, Yusuke Tsuboko, Hidekazu Miura, Yasuyuki Shiraishi, Tomoyuki Yambe

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS　2013　1815-1818　2013

DOI： 10.1109/EMBC.2013.6609875 　

ISSN： 1557-170X
Transcutaneous communication system using the human body as conductive medium: Influence of transmission data current on the heart Peer-reviewed

Okamoto, E., Kikuchi, S., Miura, H., Shiraishi, Y., Yambe, T., Mitamura, Y.

Bio-Medical Materials and Engineering　23　(1-2)　155-162　2013

DOI： 10.3233/BME-120740 　

ISSN： 0959-2989
Interbeat control of a ventricular assist device for variable pump performance Peer-reviewed

Akira Tanaka, Aoi Moriya, Makoto Yoshizawa, Yasuyuki Shiraishi, Tomoyuki Yambe

Conf Proc IEEE Eng Med Biol Soc.　2013　5735-5738　2013

DOI： 10.1109/EMBC.2013.6610853 　
小児用肺動脈弁開発のための生体弁機能のモデル循環計測・評価

坪子侑佑, 白石, 泰之, 山家, 智之, 松尾, 諭志, 齋木, 佳克, 馮, 忠剛, 梅津, 光生, 宮崎, 隆子, 山岸正明

バイオメカニズム学術講演会予稿集　33回　215-216　2012/12
Publisher:
小児人工肺動脈弁機能評価のための新しい右心系模擬循環回路開発

坪子侑佑, 鈴木, 一郎, 白石, 泰之, 山田, 昭博, 松尾, 諭志, 三浦, 英和, 西條, 芳文, 馮, 忠剛, 阿久津, 敏乃介, 梅津, 光生, 齋木, 佳克, 山家, 智之, 宮崎, 隆子, 山岸正明

人工臓器　41　(2)　S-148　2012/11
Publisher:
ISSN： 0300-0818

eISSN： 1883-6097
極細形状記憶合金線維の多層化による人工心筋システムの改良 Peer-reviewed

白石泰之, 早津, 幸弘, 秋山, 正年, 北野, 智哉, 山田, 昭博, 坪子, 侑佑, 中島, 博行, 庄内, 千紘, 柏, 公一, 西條, 芳文, 齋木, 佳克, 本間, 大, 山家智之

人工臓器　41　(2)　S-135　2012/11

ISSN： 0300-0818
New implantable therapeutic device for the control of an atrial fibrillation attack using the Peltier element. Peer-reviewed

Yambe Tomoyuki, Sumiyoshi Taketada, Koga Chihiro, Shiraishi Yasuyuki, Miura Hidekazu, Sugita Norihiro, Tanaka Akira, Yoshizawa Makoto

Conf Proc IEEE Eng Med Biol Soc　2012　5741-5744　2012/08

DOI： 10.1109/EMBC.2012.6347298 　
A New Transcutaneous Bidirectional Communication for Monitoring Implanted Artificial Heart Using the Human Body as a Conductive Medium Peer-reviewed

Okamoto, E., Kato, Y., Seino, K., Miura, H., Shiraishi, Y., Yambe, T., Mitamura, Y.

Artificial Organs　36　(10)　10　2012/07/19

DOI： 10.1111/j.1525-1594.2012.01480.x 　

ISSN： 1525-1594 0160-564X
Study of hard-shell venous reservoir for bubble devices earthquake

SUZUKI Ichiro, CHIBA Miki, TOMITA Motooki, MIYAMOTO Miyuki, TSUBOKO Yusuke, SHIRAISHI Yasuyuki, YAMBE Tomoyuki

体外循環技術　39　(2)　153-158　2012/06/01
Publisher: (一社)日本体外循環技術医学会編集委員会
ISSN： 0912-2664
低圧系拍動流循環でのエネルギー損失低減のためのBulging sinusの意義

松尾諭志, 白石, 泰之, 秋山, 正年, 山家, 智之, 齋木佳克

人工臓器　41　(1)　55-56　2012/06
Publisher:
ISSN： 0300-0818

eISSN： 1883-6097
Engineering analysis of the effects of bulging sinuses in a newly designed pediatric pulmonary heart valve on hemodynamic function Peer-reviewed

Ichiro Suzuki, Yasuyuki Shiraishi, Shota Yabe, Yusuke Tsuboko, Telma Keiko Sugai, Ken Matsue, Takeyoshi Kameyama, Yoshifumi Saijo, Takashi Tanaka, Yoshihiro Okamoto, Zhonggang Feng, Takako Miyazaki, Masaaki Yamagishi, Makoto Yoshizawa, Mitsuo Umezu, Tomoyuki Yambe

Journal of Artificial Organs　15　(1)　49-56　2012/03

DOI： 10.1007/s10047-011-0609-1 　

ISSN： 1434-7229

eISSN： 1619-0904
Nonlinear Reaction Force Analysis for Characterization of Breast Tissues Peer-reviewed

Mariko Tsukune, Yo Kobayashi, Takeharu Hoshi, Yasuyuki Shiraishi, Tomoyuki Miyashita, Tomoyuki Yambe, Masakatu G. Fujie

COMPUTER AIDED SURGERY　3　125-134　2012

ISSN： 1867-2914
Geometry Effect of Preloading Probe on Accurate Needle Insertion for Breast Tumor Treatment Peer-reviewed

Maya Hatano, Yo Kobayashi, Makiko Suzuki, Yasuyuki Shiraishi, Tomoyuki Yambe, Makoto Hashizume, Masakatsu G. Fujie

2012 IEEE INTERNATIONAL CONFERENCE ON ROBOTICS AND AUTOMATION (ICRA)　2012 Vol.3　1933-1938　2012

DOI： 10.1109/ICRA.2012.6224604 　

ISSN： 1050-4729
Examination of mitral regurgitation with a goat heart model for the development of intelligent artificial papillary muscle Peer-reviewed

Y. Shiraishi, T. Yambe, M. Yoshizawa, H. Hashimoto, A. Yamada, H. Miura, M. Hashem, T. Kitano, T. Shiga, D. Homma

2012 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　6649-6652　2012

DOI： 10.1109/EMBC.2012.6347519 　

ISSN： 1557-170X
推定流量による定常流型補助人工心臓の流量制御 Peer-reviewed

針生健太郎, 田中明, SugaiTelma Keiko, 白石泰之, 吉澤誠, 山家智之

人工臓器　40　(2)　S160-S160　2011/10
心房細動治療用デバイスの熱応答の基礎検討 Peer-reviewed

古賀千尋, 住吉剛忠, 三浦英和, 劉紅箭, 神谷蔵人, 志賀卓弥, HashemMohammed, SugaiTelma Keiko, 陳炯旬, 橋本尚, 山田昭博, 大沢上, 佐藤尚, 白石泰之, 山家智之

人工臓器　40　(2)　S146-S146　2011/10
Publisher:
ISSN： 0300-0818

eISSN： 1883-6097
生体僧房弁モデルを用いた力学検討に基づく人工乳頭筋設計 Peer-reviewed

橋本尚, 白石泰之, SugaiTelma, 志賀卓弥, 神谷蔵人, HashemMohamed, 北野智哉, 古賀千尋, 陳炯旬, 山田昭博, 坪子侑佑, 森谷葵, 三浦英和, 西條芳文, 山家智之, 本間大

人工臓器　40　(2)　S138-S138　2011/10

ISSN： 0300-0818
ニプロ補助人工心臓の駆動チューブの屈曲を検知させる方法についての研究 Peer-reviewed

柏公一, 西村隆, 杉谷弘文, 深谷碧, 久保仁, 玉井久義, 馬場敦, 白石泰之, 山家智之, 許俊鋭, 小野稔

人工臓器　40　(2)　S128-S128　2011/10
MERAモノピボット遠心血液ポンプの動物実験評価 Peer-reviewed

山根隆志, 丸山修, 西田正浩, 小阪亮, 山本好宏, 桑名克之, 白石泰之, 山家智之, 筒井達夫

人工臓器　40　(2)　S127-S127　2011/10

ISSN： 0300-0818
小型遠心ポンプを用いた定常流全置換型人工心臓の小型軽量化を目指した研究開発 Peer-reviewed

三浦英和, 陳炯旬, 志賀卓弥, 白石泰之, スガイ・テルマ・ケイコ, 劉紅箭, 山家智之

人工臓器　40　(2)　S121-S121　2011/10
小児用新型肺動脈人工弁設計における最適化のための新しい設計の基礎検討 Peer-reviewed

坪子侑佑, 鈴木一郎, 白石泰之, SugaiTelma Keiko, 北野智哉, 山田昭博, 志賀卓弥, 神谷蔵人, 劉江箭, 三浦英和, 西條芳文, 山家智之, 松尾諭志, 齋木佳克, 梅津光生, 宮崎隆子, 山岸正明

人工臓器　40　(2)　S118-S118　2011/10

ISSN： 0300-0818
人体を通信媒体とする経皮的情報通信の動物実験評価 Peer-reviewed

加藤良都, 岡本英治, 情野和幸, 三浦英和, 白石泰之, 山家智之, 三田村好矩

人工臓器　40　(2)　S63-S63　2011/10
日本発の人工臓器技術スマートアクチュエータを利用した人工心筋 Peer-reviewed

白石泰之, 秋山正年, 西條芳文, SugaiTelma Keiko, 北野智哉, 金子芳一, OmranMohamed Hashem, 山田昭博, 三浦英和, 志賀卓弥, 神谷蔵人, 森田紀代造, 山岸正明, TozziPiergiorgio, 梅津光生, 本間大, 齋木佳克, 山家智之

人工臓器　40　(2)　S26-S26　2011/10

ISSN： 0300-0818
患者自信が自分で判断して必要時に体外から駆動させる右心補助循環装置 Peer-reviewed

山家智之, 白石泰之, 三浦英和, 斎木佳克

日本心臓病学会誌　6　(Suppl.I)　331-331　2011/08
Palpation nonlinear reaction force analysis for characterization of breast tissues. Peer-reviewed

Kobayashi Yo, Tsukune Mariko, Hoshi Takeharu, Miyashita Tomoyuki, Shiraishi Yasuyuki, Yambe Tomoyuki, Fujie Masakatsu G

Conf Proc IEEE Eng Med Biol Soc　2011　7393-7396　2011/04

DOI： 10.1109/IEMBS.2011.6091721 　
人工臓器医工学を用いた胃内拡張カプセルによる自律神経系を介した食欲抑制システム Peer-reviewed

山家智之, 白石泰之, 三浦英和

自律神経　48　(2)　146-146　2011/04
Template for preparation of papers for IEEE sponsored conferences & Symposia

H. Miura, Y. Shiraishi, T. Yambe, J. X. Chen, T. K. Sugai

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS　1351-1354　2011

DOI： 10.1109/IEMBS.2011.6090318 　

ISSN： 1557-170X
In vitro and in vivo Validation of Robotic Palpation-based Needle Insertion Method for Breast Tumor treatment Peer-reviewed

Maya Hatano, Yo Kobayashi, Ryutaro Hamano, Makiko Suzuki, Yasuyuki Shiraishi, Tomoyuki Yambe, Kozo Konishi, Makoto Hashizume, Masakatsu G. Fujie

2011 IEEE INTERNATIONAL CONFERENCE ON ROBOTICS AND AUTOMATION (ICRA)　2011 Vol.1　392-397-397　2011

DOI： 10.1109/ICRA.2011.5979896 　

ISSN： 1050-4729
Structural Design of a Newly Developed Pediatric Circulatory Assist Device for Fontan Circulation by Using Shape Memory Alloy Fiber Peer-reviewed

Y. Shiraishi, T. K. Sugai, A. Tanaka, M. Yoshizawa, T. Yambe, A. Yamada, M. H. Omran, T. Shiga, T. Kitano, K. Kamiya, S. Mochizuki, H. Miura, D. Homma, M. Yamagishi

2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　8353-8355　2011

DOI： 10.1109/IEMBS.2011.6092060 　

ISSN： 1557-170X
Comparison between Estimated Cardiac Function during Left Ventricular Assistance and during No Support Peer-reviewed

T.K. Sugai, M. Yoshizawa, A. Tanaka, T. Yambe, Y. Shiraishi

ASIO　2011
【シミュレータを用いた医療機器・治療法の安全性と有効性評価の現状と展望】循環シミュレータによる右心系心臓代用弁の血行動態評価 Peer-reviewed

白石泰之, 鈴木一郎, 梅津光生, 山岸正明, 山家智之

人工臓器　39　(3)　214-217　2010/12
Publisher:
DOI： 10.11392/jsao.39.214 　

ISSN： 0300-0818
ヘリカルフロー無拍動ポンプを用いた全置換型人工心臓

山家智之, 三浦, 英和, 白石, 泰之, 齋木佳克

日本心臓病学会誌　5　(Suppl.I)　385-385　2010/08
Publisher:
ISSN： 1882-4501
ナノテクノロジーを応用したテーラーメイド人工心筋 Peer-reviewed

山家智之, 白石泰之, 三浦英和, 馬場敦, 井街宏, 早瀬敏幸, 円山重直, 柴田宗一, 三引義明, 大沢上, 佐藤尚

東北医学雑誌　122　(1)　65-70　2010/06
Estimation of maximum ventricular elastance under assistance with a rotary blood pump Peer-reviewed

Sugai, T.K., Tanaka, A., Yoshizawa, M., Shiraishi, Y., Yambe, T., Nitta, S.-I., Baba, A.

Artificial Organs　34　(5)　442-446　2010/05

DOI： 10.1111/j.1525-1594.2009.00876.x 　

ISSN： 1525-1594 0160-564X
【循環制御の基礎の進歩】循環制御機能をコントロールすることができる乗用車の可能性の展開 Peer-reviewed

山家智之, 金野敏, 白石泰之, 劉紅煎, 川島隆太, 阿部恒之, 杉田典大, 吉沢誠, 関隆志

循環制御　30　(3)　127-141　2010/05
Influence of rotary blood pumps over preload recruitable stroke work. Peer-reviewed

Sugai Telma Keiko, Tanaka Akira, Yoshizawa Makoto, Shiraishi Yasuyuki, Baba Atsushi, Yambe Tomoyuki, Nitta Shin-Ichi

Conf Proc IEEE Eng Med Biol Soc　2010　2367-2370　2010/04

DOI： 10.1109/IEMBS.2010.5627916 　
Physiological effects of the assistance of centrifugal flow rotary blood pumps Peer-reviewed

T.K. Sugai, Akira Tanaka, Makoto Yoshizawa, Yasuyuki Shiraishi, Atsushi Baba, Tomoyuki Yambe, Shin-ichi Nitta

5th International Symposium on Medical, Bio- and Nano-Electronics　97-98　2010/02
診断治療機能を保持する自動車の可能性 Peer-reviewed

山家智之, 金野敏, 白石泰之, 川島隆太, 阿部恒之, 杉田典大, 吉沢誠, 関隆志

日本臨床生理学会雑誌　40　(1)　5-14　2010/02

ISSN： 0286-7052
Tangible Modelling of Ventricular Aneurysm Peer-reviewed

Y. Shiraishi, S. Yabe, H. Lin, T. K. Sugai, Y. Saijo, T. Fujimoto, M. Umezu, T. Yambe, Y. Saiki, K. Tabayashi

6TH WORLD CONGRESS OF BIOMECHANICS (WCB 2010), PTS 1-3　31　469-+　2010

ISSN： 1680-0737
人工心筋と生体の適応 Peer-reviewed

白石泰之, 金子芳一, 金野敏, 劉紅箭, 山家智之, 佐藤優太, 馬場敦, 藤本哲男, 梅津光生, 本間大

適応医学　13　(2)　2-8　2010/01
各種疾患自律神経疾患人工血圧反射 Peer-reviewed

山家智之, 三浦英和, 白石泰之, 吉澤誠, 田中明

Annual Review神経　2010　259-266　2010/01
Comparison of ventricular contractility indices during assistance switched by two different rotary blood pumps Peer-reviewed

T.K. Sugai, Akira Tanaka, Makoto Yoshizawa, Yasuyuki Shiraishi, Atsushi Baba, Tomoyuki Yambe, Shin-ichi Nitta

17th Congress of the International Society for Rotary Blood Pumps　2009/10
Hemodynamic response with an artificial myocardial assistance in chronic animal, examination Peer-reviewed

Y. Shiraishi, T. Yambe, Y. Saijo, M. Shibata, H. Liu, T. Sugai, A. Tanaka, S. Konno, A. Baba T, Fujimoto K, Imachi M. Yoshizawa, S. Nitta, H. Sasada, K. Tabayashi, Y. Sato, M, Umezu D, Hom

WC 2009, IFMBE Proceedings　25　(8)　277-280　2009/09

DOI： 10.1007/978-3-642-03887-7-80 　
Baroreflex Sensitivity of an Arterial Wall during Rotary Blood Pump Assistance Peer-reviewed

Yambe, T., Imachi, K., Shiraishi, Y., Yamaguchi, T., Shibata, M.-I., Kameyama, T., Yoshizawa, M., Sugita, N.

Artificial Organs　33　(9)　767-770　2009/09

DOI： 10.1111/j.1525-1594.2009.00864.x 　

ISSN： 1525-1594 0160-564X
Chronic Trial of an Artificial Myocardium in Goats and Preliminary Modelling of Diseased Heart Peer-reviewed

Yasuyuki Shiraishi, Tomoyuki YambeSatoshi KonnoYoshihumi SaijoMuneichi ShibataHongjian LiuHiroshi, SasadaKoichi TabayashiTelma Keiko SugaiAtsushi BabaMakoto YoshizawaMitsuo UmezuTetsuko FujimotoAkira, TanakaDai Homma

Tohoku University Global COE Programme　2　213-221　2009/09
Analysis of baroreflex sensitivity during undulation pump ventricular assist device support Peer-reviewed

Liu, H., Shiraishi, Y., Zhang, X., Song, H., Saijo, Y., Baba, A., Yambe, T., Abe, Y., Imachi, K.

Artificial Organs　33　(7)　561-565　2009/07

DOI： 10.1111/j.1525-1594.2009.00738.x 　

ISSN： 1525-1594 0160-564X
Assessment of synchronization measures for effective ventricular support by using the shape memory alloy fibred artificial myocardium in goats. Peer-reviewed

Shiraishi Y, Yambe T, Saijo Y, Sato F, Tanaka A, Yoshizawa M, Sugai T K, Kaneko Y, Sato Y, Uematsu M, Umezu M, Fujimoto T, Masumoto N, Liu H, Baba A, Konno S, Tabayashi K, Sasada H, Homma D

Conf Proc IEEE Eng Med Biol Soc　2009　3047-3050　2009/04

DOI： 10.1109/IEMBS.2009.5333627 　
Clinical comparison of two different types of bifurcated graft for postoperative baPWV and ABI

Iwahashi, T., Obitsu, Y., Koizumi, N., Shiraishi, Y., Shigematsu, H.

International Angiology　28　(3)　2009

ISSN： 0392-9590
Clinical research on the accuracy in determining the pulse wave rising point

T. Yambe, Y. Shiraishi, Y. Saijo, H. Liu, S. Nitta, K. Imachi, A. Baba, T. Yamaguchi, S. Sugawara, Y. Katahira, N. Ohsawa, Y. Mibiki, M. Watanabe, M. Shibata, N. Sato, T. Kameyama, N. Akino, M. Munakata, M. Honda, M. Yoshizawa, N. Sugita

Scripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae　82　(3)　164-174　2009

ISSN： 1211-3395
Automobile, which can control an autonomic nervous system

T. Yambe, Y. Shiraishi, M. Takashima, T. Seki, R. Kawashima

IFMBE Proceedings　25　(9)　115-118　2009
Publisher: Springer Verlag
DOI： 10.1007/978-3-642-03889-1_31 　

ISSN： 1680-0737
Nano technology for the development of artificial internal organs

T. Yambe, Y. Shiraishi, H. Miura, G. Miyata, K. Tabayashi, K. Imachi

IFMBE Proceedings　25　(7)　536-539　2009
Publisher: Springer Verlag
DOI： 10.1007/978-3-642-03885-3_149 　

ISSN： 1680-0737
Estimation of E-max of Assisted Hearts using Single Beat Estimation Method Peer-reviewed

T. K. Sugai, A. Tanaka, A. Yoshizawa, Y. Shiraishi, S. Nitta, T. Yambe, A. Baba

13TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, VOLS 1-3　23　(1-3)　2177-+　2009

ISSN： 1680-0737
First Trial of the Chronic Animal Examination of the Artificial Myocardial Function Peer-reviewed

Y. Shiraishi, T. Yambe, Y. Saijo, K. Matsue, M. Shibata, H. Liu, T. Sugai, A. Tanaka, S. Konno, H. Song, A. Baba, K. Imachi, M. Yoshizawa, S. Nitta, H. Sasada, K. Tabayashi, R. Sakata, Y. Sato, M. Umezu, D. Homma

13TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, VOLS 1-3　23　(1-3)　2268-+　2009

ISSN： 1680-0737
Preliminary Study on Interactive Control for the Artificial Myocardium by Shape Memory Alloy Fibre Peer-reviewed

R. Sakata, Y. Shiraishi, Y. Sato, Y. Saijo, T. Yambe, Y. Luo, D. Jung, A. Baba, M. Yoshizawa, A. Tanaka, T. K. Sugai, F. Sato, M. Umezu, S. Nitta, T. Fujimoto, D. Homma

13TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, VOLS 1-3　23　(1-3)　1409-+　2009

ISSN： 1680-0737
形状記憶合金人工心筋駆動下の自律神経活動と圧反射感受性解析の試み Peer-reviewed

劉紅箭, 白石泰之, 鄭徳泳, 羅雲, 山家智之

人工臓器　37　(2)　S-163　2008/11
Long-Term Implantation of Subcutaneously Implantable Artificial Sphincters

Yun Luo, Shintaro Amae, Ye Zhang, Tomoyuki Yambe, Yasuyuki Shiraishi, H. Liu

International Journal of Artificial Organs　31　(7)　595-595　2008/07
【食道疾患の臨床 update】食道癌食道癌ステント治療の未来 Invited Peer-reviewed

山家智之, 白石泰之, 西條芳文, 宮田剛, 里見進, 佐藤文博, 松木英敏, 関根一光

臨床消化器内科　23　(7)　1056-1059　2008/05
Preliminary study on the estimation of Emax using single-beat methods during assistance with rotary blood pumps. Peer-reviewed

Sugai Telma Keiko, Tanaka Akira, Yoshizawa Makoto, Shiraishi Yasuyuki, Baba Atsushi, Yambe Tomoyuki, Nitta Shin-ichi

Conf Proc IEEE Eng Med Biol Soc　2008　973-976　2008/04

DOI： 10.1109/IEMBS.2008.4649317 　
Swallow stent with hyperthermia function. Peer-reviewed

Yambe Tomoyuki, Sato Fumihiro, Matsuki Hidetoshi, Shiraishi Yasuyuki, Miyata Go, Satomi Susumu

Conf Proc IEEE Eng Med Biol Soc　2008　731-734　2008/04

DOI： 10.1109/IEMBS.2008.4649256 　
Detection of Cardiac Function during Rotary Blood Pump Assistance Peer-reviewed

T.K. Sugai, A. Tanaka, M. Yoshizawa, D. Ogawa, Y. Shiraishi, T. Yambe, S. Nitta

3rd Int. Symp. on Medical, Bio- and Nano-Electronics　2008/03
Estimation of Cardiac Function during Cardiac Assistance with a Rotary Blood Pump Peer-reviewed

Makoto Yoshizawa, Telma Keiko Sugai, Akira Tanaka, Daisuke Ogawa, Yasuyuki Shiraishi, Tomoyuki Yambe, Shin-ichi Nitta

Proceeding of the 5th International Symposium of 2007 Tohoku University Global COE Program: Global Nano-Biomedical Engineering Education and Research Network Centre Nano-Biomedical Engineering in the East Asian-Pacific Rim Region　51-54　2008/03
A study on a newly designed aortofemoral prosthetic y graft

Fujimoto, T., Nakano, S., Iwamura, H., Shiraishi, Y., Yambe, T., Umezu, M.

Biocybernetics and Biomedical Engineering　28　(1)　2008

ISSN： 0208-5216
Quantitive evaluation of the baroreflex sensitivity of an artery

T. Yambe, Y. Shiraishi, Y. Saijo, H. Liu, S. Nitta, K. Imachi, A. Baba, T. Yamaguchi, S. Sugawara, Y. Katahira, N. Ohsawa, Y. Mibiki, M. Watanabe, M. Shibata, N. Sato, Y. Kameyama, N. Akino, M. Munakata, M. Honda, M. Yoshizawa, N. Sugita

Scripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae　81　(4)　249-260　2008

ISSN： 1211-3395
Engineering Support in Surgical Strategy for Ventriculoplasty Peer-reviewed

Yasuyuki Shiraishi, T. Yambe, Y. Saijo, S. Masuda, G. Takahashi, K. Tabayashi, T. Fujimoto, M. Umezu

IFMBE Proceedings　22　2564-2567　2008

DOI： 10.1007/978-3-540-89208-3_615 　

ISSN： 1680-0737
Sensorless control for a sophisticated artificial myocardial contraction by using shape memory alloy fibre. Peer-reviewed

Shiraishi Y, Yambe T, Saijo Y, Sato F, Tanaka A, Yoshizawa M, Sugai TK, Sakata R, Luo Y, Park Y, Uematsu M, Umezu M, Fujimoto T, Masumoto N, Liu H, Baba A, Konno S, Nitta S, Imachi K, Tabayashi K, Sasada H, Homma D

Conf Proc IEEE Eng Med Biol Soc. 2008　711-714　2008
EVALUATION OF Emax ESTIMATION BASED ON MOTOR CURRENT AND ROTATIONAL SPEED Peer-reviewed

T.K. Sugai, A. Tanaka, M. Yoshizawa, Y. Shiraishi, T. Yambe, S. Nitta

15th Congress of International Society for Rotary Blood Pumps　2007/11
医工学による右心流出路再建の評価方法

末永健, 白石泰之, 西條芳文, 山家智之, 馮忠剛, 中村孝夫, 宮崎隆子, 山岸正明, 田中隆, 岡本吉弘, 梅津光生

人工臓器　36　(2)　S109-S109　2007/10
Cardiopulmonary 定常流型補助人工心臓の制御方式の相違が自己心に与える影響

笠原孝一郎, 田中明, 吉澤誠, 阿部健一, 白石泰之, 山家智之, 仁田新一

人工臓器　36　(2)　S62-S62　2007/10
Passive mechanical properties of large intestine under in vivo and in vitro compression Peer-reviewed

Masaru Higa, Yun Luo, Takeshi Okuyama, Toshiyuki Takagi, Yasuyuki Shiraishi, Tomoyuki Yambe

MEDICAL ENGINEERING & PHYSICS　29　(8)　840-844　2007/10

DOI： 10.1016/j.medengphy.2006.09.003 　

ISSN： 1350-4533
Macrophage colony-stimulating factor improves cardiac function after ischemic injury by inducing vascular endothelial growth factor production and survival of cardiomyocytes Peer-reviewed

Tatsuma Okazaki, Satoru Ebihara, Masanori Asada, Shinsuke Yamanda, Yoshifumi Saijo, Yasuyuki Shiraishi, Takae Ebihara, Kaijun Niu, He Mei, Hiroyuki Arai, Tomoyuki Yambe

AMERICAN JOURNAL OF PATHOLOGY　171　(4)　1093-1103　2007/10

DOI： 10.2353/ajpath.2007.061191 　

ISSN： 0002-9440
定常流型補助人工心臓と心機能に関する実験的研究

山家智之, 白石泰之, 田林晄一, 吉澤誠

Journal of Cardiology　50　(Suppl.I)　567-567　2007/08
脈波の立ち上がりポイント測定の正確性に関する臨床研究 Invited Peer-reviewed

山家智之, 西條芳文, 白石泰之, 川田浩, 金野敏, 仁田新一, 山口済, 中島博行, 片平美明, 柴田宗一, 渡辺誠, 三引義明, 大沢上, 佐藤尚, 秋野能久, 本多正久

エレクトロニクスの臨床　(76)　23-34　2007/07
動脈の血圧反射機能感受性診断装置の発明 Invited

山家智之, 川田浩, 丸山満也, 金野敏, 西條芳文, 白石泰之, 仁田新一, 吉澤誠, 杉田典大, 田中明, 宗像正徳, 山口佑, 片平美明, 秋野能久, 本多正久, 柴田宗一, 渡辺誠, 三引義明, 大沢上, 佐藤尚

東北医学雑誌　119　(1)　73-77　2007/06
形状記憶合金を用いた人工的蠕動運動型人工食道

関根一光, 山家智之, 西條芳文, 白石泰之, 松木英敏, 佐藤文博, 前田剛, 中澤文雄

北海道外科雑誌　52　(1)　85-85　2007/06
鍼灸所見の臨床的意義と客観化六部定位の脈診について脈波情報の客観化と脈診 Invited Peer-reviewed

丸山満也, 金野敏, 仁田新一, 高島充, 白石泰之, 山家智之, 関隆志, 荒井啓行, 太田信, 劉磊, 白井敦, 早瀬敏幸

全日本鍼灸学会雑誌　57　(2)　116-118　2007/05
Publisher: The Japan Society of Acupuncture and Moxibustion
DOI： 10.3777/jjsam.57.110 　

ISSN： 0285-9955

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The purpose of this symposium was to clarify clinical significance of the pulse diagnosis at the wrist used for detecting the function of various organs. Base of the literature survey and his personal experiences, the importance of reliability (reproducibility) test of the pulse diagnosis in blinded manner and necessity of clinical trials with "_??_"-specific intervention was proposed by Ogawa. A unique training program of the pulse diagnosis was introduced by Kido, and he also demonstrated a significant positive result of "_??_"-specific intervention determined by the pulse diagnosis procedure in his program and suggested the clinical significance of the pulse diagnosis. Detection of various changes in pulse waveforms at the wrist using pressure transducer was demonstrated by Maruyama, and he also suggested a possible progress of objectivity in pulse diagnosis by various sensors and biomedical devices in future. From circulatory physiological point of view, factors which may affect the pressure pulse wave at the wrist were explained with several examples of pathologic conditions by Chihara. He also suggested a possibility of reflection of general condition in the pressure pulse at the wrist although it might be partial one, and stressed the necessity of other information for the accurate diagnosis. In general discussion, it was pointed out that evidence of the pulse diagnosis was still limited, and further experimental approaches of the pulse diagnosis will be required.
【機械的循環制御】定常流型補助人工心臓の循環制御は不要か? Peer-reviewed

吉澤誠, 田中明, 小川大祐, 笠原孝一郎, ポール・オレガリオ, 白石泰之, 関根一光, 山家智之, 仁田新一

循環制御　28　(1)　4-11　2007/03

ISSN： 0389-1844
Evaluation of Cardiac Function of the Patients with Left Ventricular Assist Device by Transesophageal Echocardiography Peer-reviewed

Y. Saijo, Y. Saiki, A. Iguchi, K. Tabayashi, Y. Shiraishi, K. Sekine, T. Yambe

WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING 2006, VOL 14, PTS 1-6　14　4146-+　2007

ISSN： 1680-0737
Development of the displacement amplification mechanism for myocardial assist device

Watabe Tomoki, Shiraishi Yasuyuki, Wada Yumiko, Sakata Ryo, Saijo Yoshifumi, Yambe Tomoyuki, Homma Dai, Shibata Souichi, Umezu Mitsuo

Journal of Life Support Technology　19　192-192　2007
Publisher: The Society of Life Support Engineering
DOI： 10.5136/lifesupport.19.Supplement_192 　

ISSN： 1341-9455
Support mechanism of a newly-designed mechanical artificial myocardium using shape memory alloy fibres

Yasuyuki Shiraishi, T. Yambe, S. Itoh, R. Sakata, Y. Wada, K. Sekine, Y. Saijo, S. Konno, S. Nitta, Q. Wang, H. Liu, M. Higa, Y. Luo, D. Ogawa, A. Tanaka, M. Yoshizawa, Y. Kakubari, H. Miura, F. Sato, H. Matsuki, M. Uematsu, Y. Park, T. Tanaka, M. Umezu, T. Fujimoto, N. Masumoto, Y. Hori, H. Sasada, K. Tabayashi, E. Okamoto, D. Homma

IFMBE Proceedings　14　(1)　3161-3164　2007

DOI： 10.1007/978-3-540-36841-0_799 　

ISSN： 1680-0737

eISSN： 1433-9277
In vivo measurement and constitutive modeling of colon tissue Peer-reviewed

Masaru Higa, Y. Luo, T. Okuyama, T. Takagi, T. Yambe, Y. Shiraishi, H. Liu

World Congress on Medical Physics and Biomedical Engineering 2006 (Springer Berlin Heidelberg)　3186-3189　2007
心臓血管系に整合する人工血管開発のための医工学的評価手法 Peer-reviewed

白石泰之, 岩村弘志, 藤本哲男, 梅津光生, 川副浩平

適応医学　10　(2)　14-23　2007/01
Biochemical evaluation of an artificial anal sphincter made from shape memory alloys Peer-reviewed

Hongjian Liu, Yun Luo, Masaru Higa, Xiumin Zhang, Yoshifumi Saijo, Yasuyuki Shiraishi, Kazumitsu Sekine, Tomoyuki Yambe

JOURNAL OF ARTIFICIAL ORGANS　10　(4)　223-227　2007

DOI： 10.1007/s10047-007-0395-y 　

ISSN： 1434-7229
Morphological approach for the functional improvement of an artificial myocardial assist device using shape memory alloy fibres Peer-reviewed

Y. Shiraishi, T. Yambe, Y. Saijo, F. Sato, A. Tanaka, A. Yoshizawa, D. Ogawa, Y. Wada, S. Itoh, R. Sakata, Y. Park, A. Uematsu, A. Umezu, T. Fujimoto, N. Masumoto, H. Liu, A. Baba, S. Konno, S. Nitta, K. Imachi, K. Tabayashi, H. Sasada, D. Homma

2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16　2007　3974-3977　2007

DOI： 10.1109/IEMBS.2007.4353204 　

ISSN： 1094-687X
Quantitative evaluation for anastomotic technique of coronary artery bypass grafting by using in-vitro mock circulatory system Peer-reviewed

Young Kwang Park, Yutaka Mita, Eriko Oki, Naohiko Kanemitsu, Yasuyuki Shiraishi, Yousuke Ishii, Takashi Azurna, Masarni Ochi, Mitsuo Umezu

2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16　2007　2705-+　2007

DOI： 10.1109/IEMBS.2007.4352887 　

ISSN： 1094-687X
脈診における脈派情報の取得に関する数学モデルの構築と実験による検証

鳴海賢太郎, 中西勉, 劉磊, 井上浩介, 白井敦, 早瀬敏幸, 太田信, 金野敏, 川田浩, 丸山満也, 白石泰之, 仁田新一

第17回バイオフロンティア講演会講演論文集　6　(46)　55-56　2006/11
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
Mechanical Myocardial Assistance by the Shape Memory Alloy Fibre

SHIRAISHI Yasuyuki, YAMBE Tomoyuki, SEKINE Kazumitsu, SAIJO Yoshifumi, KONNO Satoshi, NITTA Shin-ichi, UMEZU Mitsuo, HOMMA Dai, OKAMOTO Eiji

電気学会研究会資料. LD, リニアドライブ研究会　2006　(48)　65-68　2006/10/26
形状記憶合金を応用した人工心筋要素の機械特性と駆動制御に関する基礎検討 Peer-reviewed

伊藤慎二, 白石泰之, 和田由美子, 坂田亮, 植松美幸, 田中隆, 小川大祐, 関根一光, 吉澤誠, 田中明, 西條芳文, 山家智之, 岡本英治, 本間大, 藤本哲男, 梅津光生

人工臓器　35　(2)　S167-S167　2006/10
長期埋込型形状記憶合金人工括約筋の生体適合性評価 Peer-reviewed

劉紅箭, 羅雲, 比嘉昌, 西條芳文, 白石泰之, 関根一光, 山家智之

人工臓器　35　(2)　S166-S166　2006/10
定常流型人工心臓装着時の心機能評価動物実験およびモデルによる検討 Peer-reviewed

小川大祐, 田中明, 吉澤誠, 阿部健一, OlegarioPaul, 笠原孝一郎, 白石泰之, 関根一光, 山家智之, 仁田新一

人工臓器　35　(2)　S160-S160　2006/10
補助人工心臓用制御アルゴリズム開発のための循環系シミュレータ Peer-reviewed

笠原孝一郎, 田中明, 吉澤誠, 阿部健一, OlegarioPaul, 小川大祐, 白石泰之, 関根一光, 山家智之, 仁田新一

人工臓器　35　(2)　S159-S159　2006/10
東北大学における無拍動流左心補助人工心臓EVAHEARTの長期動物実験による評価 Peer-reviewed

王慶田, 山家智之, 白石泰之, 関根一光, 西條芳文, 仁田新一, 井街宏, 山崎健二, 北野智哉, 山崎俊一

人工臓器　35　(2)　S156-S156　2006/10
再生医療の評価方法としての高周波数超音波の可能性 Peer-reviewed

西條芳文, 白石泰之, 関根一光, 山家智之, 佐野博高, 萩原嘉広, 服部弘之, 田中明, 穂積直裕, 小林和人

人工臓器　35　(2)　S121-S121　2006/10
Publisher:
ISSN： 0300-0818

eISSN： 1883-6097
微細機能繊維を応用した機械式人工心筋の開発心室補助効果と血管負荷整合 Peer-reviewed

白石泰之, 山家智之, 西條芳文, 関根一光, 小川大祐, 佐藤文博, 角張泰之, 伊藤慎二, 坂田亮, 和田由美子, 田中隆, 梅津光生, 田林晄一, 比嘉昌, 田中明, 吉澤誠, 藤本哲男, 増本憲泰, 仁田新一

人工臓器　35　(2)　S98-S98　2006/10

ISSN： 0300-0818
形状記憶合金を使用した蠕動運動アクチュエータの人工臓器としての可能性 Peer-reviewed

関根一光, 白石泰之, 山家智之, 西條芳文, 堀義生, 松木英敏, 佐藤文博, 角張泰之, 三浦英和, 前田剛, 仁田新一

人工臓器　35　(2)　S76-S76　2006/10

ISSN： 0300-0818
手術ロボットと低侵襲化対策低侵襲手術を定量評価するための医工学的アプローチ Peer-reviewed

梅津光生, 朴栄光, 白石泰之, 有田誠, 岩崎清隆, 田中隆, 青見茂之, 加瀬川均, 竹村博文, 夜久均, 川副浩平

人工臓器　35　(2)　S57-S57　2006/10
Publisher:
DOI： 10.11392/jsao1972.35.2_S57 　

ISSN： 0300-0818
人工臓器・ME機器と生体の適応バイオエンジニアリングによる人工血管性能評価および手術支援 Invited

白石泰之, 梅津光生

適応医学　10　(1)　18-18　2006/06
人工心筋を応用した新しい機械式心臓モデル構築の試み Peer-reviewed

白石泰之, 伊藤慎二, 山家智之, 永利潤, 西條芳文, 関根一光, 金野敏, 朴栄光, 植松美幸, 増本憲泰, 田中隆, 藤本哲男, 梅津光生, 本間大

生体医工学　44　(2)　320-320　2006/06
蠕動運動機能を有する生体内埋め込み可能な人工食道の開発研究 Peer-reviewed

関根一光, 山家智之, 西條芳文, 白石泰之, 堀義生, 松木英敏, 佐藤文博

北海道外科雑誌　51　(1)　79-79　2006/06

ISSN： 1347-443X
Impact of Type A behavior on brachial-ankle pulse wave velocity in Japanese Peer-reviewed

HJ Liu, Y Saijo, XM Zhang, Y Shiraishi, Y Luo, M Maruyama, M Higa, K Sekine, T Yambe

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　209　(1)　15-21　2006/05

DOI： 10.1620/tjem.209.15 　

ISSN： 0040-8727

eISSN： 1349-3329
21 COE artificial organ project using regenerative medicine and nano technology : In artificial internal organs, smaller is better. And an important issue is bio affinity. From these points of view, Regenerative medicine and Nano technology are very useful technology. In Tohoku University, various artificial internal organ research including Artificial esophagus, Artificial Myocardium, and Artificial sphincter based on 21 COE program. Ideal artificial organs may be embodied in future Peer-reviewed

YAMBE Tomoyuki, HORI Yoshio, SHIRAISHI Yasuyuki, SEKINE Kazumitsu, IGUCHI Atsushi, TABAYASHI Kouichi, HAGA Youichi, ESASHI Masayoshi, YOSHIZAWA Makoto, TANAKA Akira, MATSUKI Hidetoshi, SATO Fumihiro, KAWANO Satoyuki, LUO Yun, HIGA Masaru, TAKAGI Toshiyuki, HAYASE Toshiyuki, MARUYAMA Shigenao, WANG Quintian, DHUANG Kyokuto, NITTA Shinichi, IMACHI Kou, SASADA Hiroshi, SATO Eimei, SATO Masaaki, OKAMOTO Eiji, KUBO Yutaka, OSAKA Motohisa, UMETSU Mitsuo, HONMA Dai, MAEDA Takeshi

Ensho Saisei　26　(1)　35-39　2006/01/25
Publisher: The Japanese Society of Inflammation and Regeneration
DOI： 10.2492/jsir.26.35 　

ISSN： 1346-8022

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In artificial internal organs, smaller is better. And an important issue is bio affinity. From these points of view, Regenerative medicine and Nano technology are very useful technology. In Tohoku University, various artificial internal organ research including Artificial esophagus, Artificial Myocardium, and Artificial sphincter based on 21 COE program. Ideal artificial organs may be embodied in future.
Comparative analysis of cardio-ankle vascular index between Japanese and Russians Peer-reviewed

Hongjian Liu, Yoshifumi Saijo, Xiumin Zhang, Yasuyuki Shiraishi, Kazumitsu Sekine, Mitsuya Maruyama, Yori A. Kovalev, Irina A. Milyagina, Viktor A. Milygin, Tomoyuki Yambe

FUTURE MEDICAL ENGINEERING BASED ON BIONANOTECHNOLOGY, PROCEEDINGS　411-+　2006
Development of "Patient Robot"; Training robot based on quantitative analysis of surgical technique Peer-reviewed

Young-Kwang Park, Yutaka Mita, Eriko Oki, Hiroyasu Iwata, Atsuo Takanishi, Mitsuo Umezu, Yasuyuki Shiraishi, Hirofumi Takemura

2006 1ST IEEE RAS-EMBS INTERNATIONAL CONFERENCE ON BIOMEDICAL ROBOTICS AND BIOMECHATRONICS, VOLS 1-3　1144-+　2006

ISSN： 2155-1782
Development of "patient robot"; Measurement system of myocardial behaviors for the quantitative evaluation of the surgical robot technology Peer-reviewed

Miyuki Uematsu, Hayato Ando, Atsushi Morita, Sigeru Uesugi, Kiyotaka Iwasaki, Mitsuo Umezu, Yasuyuki Shiraishi

2006 1ST IEEE RAS-EMBS INTERNATIONAL CONFERENCE ON BIOMEDICAL ROBOTICS AND BIOMECHATRONICS, VOLS 1-3　1172-+　2006

DOI： 10.1109/BIOROB.2006.1639164 　

ISSN： 2155-1782
Autonomic nervous activity revealed by a new physiological index rho(max) based on cross-correlation between mayer-wave components of blood pressure and heart rate Peer-reviewed

Akira Tanaka, Norihiro Sugita, Makoto Yoshizawa, Yasuyuki Shiraishi, Tomoyuki Yambe, Shin-Ichi Nitta

2006 SICE-ICASE INTERNATIONAL JOINT CONFERENCE, VOLS 1-13　4352-+　2006
Evaluation of an index for cardiac function during assistance with a rotary blood pump Peer-reviewed

D. Ogawa, A. Tanaka, K. Abe, P. Olegario, K. Kasahara, Y. Shiraishi, K. Sekine, T. Yambe, S. Nitta, M. Yoshizawa

FUTURE MEDICAL ENGINEERING BASED ON BIONANOTECHNOLOGY, PROCEEDINGS　1025-+　2006
Evaluation of the hemodynamic parameters during circulatory assistance using an electro-hydraulic artificial myocardium system Peer-reviewed

Qingtian Wang, Tomoyuki Yambe, Yasuyuki Shiraishi, Kazumitsu Sekine, Yoshifumi Saijo, Shin-Ichi Nitta, Makoto Yoshizawa, Mitsuo Umezu, Kouichi Tabayashi

FUTURE MEDICAL ENGINEERING BASED ON BIONANOTECHNOLOGY, PROCEEDINGS　557-+　2006
S-14 超音波による心臓・血管の中の流れの医工学的解析(特別企画II(要望演題5) 逆流性疾患・閉塞性疾患・拡張性疾患に対する治療戦略-管と流れと-,第43回日本小児外科学会総会)

西條芳文, 白石泰之, 関根一光, 山家智之, 田中元直, 田林晄一, 早瀬敏幸, 船本健一, 大槻茂雄, 菅原重生

日本小児外科学会雑誌　42　(3)　355-355　2006
Publisher: 特定非営利活動法人日本小児外科学会
DOI： 10.11164/jjsps.42.3_355_2 　
Preliminary study on the functional reproduction of an artificial myocardium using covalent shape memory alloy fibre based on control engineering

Yasuyuki Shiraishi, Tomoyuki Yambe, Kazumitsu Sekine, Yoshifumi Saijo, Satosni Konno, Shin Ichi Nitta, Qingtian Wang, Hongjian Liu, Masaru Higa, Daisuke Ogawa, Akira Tanaka, Makoto Yoshizawa, Yasuyuki Kakubari, Hidekazu Miura, Fumihiro Sato, Hidetoshi Matsuki, Shinji Itoh, Akinori Kamoda, Ryo Sakata, Yumiko Wada, Miyuki Uematsu, Youngkwang Park, Takashi Tanaka, Mitsuo Umezu, Tetsuo Fujimoto, Noriyasu Masumoto, Hiroshi Sasada, Koichi Tabayashi, Eiji Okamoto, Dai Homma

2006 SICE-ICASE International Joint Conference　1734-1737　2006

DOI： 10.1109/SICE.2006.315627 　
Simulation of atrial wall suction in a continuous flow total artificial heart model Peer-reviewed

Paul S. Olegario, Makoto Yoshizawa, Akira Tanaka, Daisuke Ogawa, Yasuyuki Shiraishi, Tomoyuki Yambe, Shin-ichi Nitta

2006 SICE-ICASE INTERNATIONAL JOINT CONFERENCE, VOLS 1-13　5266-+　2006
Evaluation of cardiac function based on ventricular pressure-volume relationships during assistance with a rotary blood pump. Peer-reviewed

Daisuke Ogawa, Akira Tanaka, Ken-ichi Abe, Paul Olegario, Koichiro Kasahara, Yasuyuki Shiraishi, Kazumitsu Sekine, Tomoyuki Yambe, Shin-ichi Nitta, Makoto Yoshizawa

2006 28TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-15　1　4442-+　2006

DOI： 10.1109/IEMBS.2006.260079 　
左心室形成術における切除線決定のための診断法に関する基礎的検討 Peer-reviewed

植松美幸, 白石泰之, 関根一光, 山家智之, 西條芳文, 安藤隼人, 朴栄光, 武田朴, 岩崎清隆, 梅津光生

生体医工学　43　(4)　653-660　2005/12
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.43.653 　

ISSN： 1347-443X

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Ventricular aneurysm is one of the complications that follow a myocardial infarction. Left ventricular (LV) plastic and reconstructive surgery, Dor procedure, is widely performed in order to improve patients' cardiac functions. However, it is anticipated that the abscission region of the ventricle might cause some complications, such as mitral valve regurgitation. Therefore, the decision of what to be done with that area might affect therapeutic consequences. In this study, the authors have developed a measurement system for surface movement and a display system to demonstrate decreased LV systolic function during surgery. This system is capable of evaluating the cardiac function using displacement data obtained from superficial motion of the specific regions. Prior to measurement, the reflective ball markers were sutured on the surface of the heart without any complications or infarctions. The point of the markers indicated the anatomically specific points, such as apex, septum, mitral valve, and papillary muscles. The location of points was sequentially measured by an optical three-dimensional location sensor. The superficial area of the left ventricle from the left thoracotomy view was divided into 12 triangular regions each composed of three markers. As the contraction of the regional area corresponds to the cardiac systolic function, the changes in each area were examined. The contraction rate of the heart was superimposed onto the video images of a natural heart, which were obtained simultaneously. An animal study was performed to compare heart functions under a normal pulsating state and during the time of a myocardial infarction. The physical data such as electrocardiogram, blood flow and pressure were simultaneously obtained and compared using this approach. With the physical data, it was confirmed that strain change in the regional area was coincident with a contraction of the actual heart. It was also found that this method is simple enough to set up in the operation theater. In the near future, this method will contribute widely to the clinical diagnoses of patients, when advanced surgery such as robot surgery and/or organ transplant become popular.
Comparison of brachial-ankle pulse wave velocity in Japanese and Russians Peer-reviewed

HJ Liu, T Yambe, XM Zhang, Y Saijo, Y Shiraishi, K Sekine, M Maruyama, YA Kovalev, IA Milyagina, VA Milyagin, S Nitta

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　207　(4)　263-270　2005/12

DOI： 10.1620/tjem.207.263 　

ISSN： 0040-8727

eISSN： 1349-3329
異なる2つのタイプの分岐型人工血管のPWVを用いた比較,検討 Peer-reviewed

岩橋徹, 内山裕智, 中村慶太, 佐藤和弘, 小泉信達, 張益商, 小櫃由樹生, 白石泰之

人工臓器　34　(2)　S-145　2005/11
補助人工心臓用定常流ポンプ装着時の心機能評価法の検討 Peer-reviewed

小川大祐, 田中明, 阿部健一, PaulOlegario, 笠原孝一郎, 白石泰之, 関根一光, 山家智之, 仁田新一, 吉澤誠

人工臓器　34　(2)　S-139　2005/11
波動型人工補助心臓用高効率経皮的電力伝送システムの開発 Peer-reviewed

三浦英和, 荒井真輔, 角張泰之, 佐藤文博, 斉藤逸郎, 井上雄介, 磯山隆, 鎮西恒雄, 阿部裕輔, 瀧浦晃基, 牧野勤, 望月修一, 白石泰之, 関根一光, 岡本英治, 山家智之, 三田村好矩, 井街宏, 松木英敏, 佐藤忠邦

人工臓器　34　(2)　S-137　2005/11

ISSN： 0300-0818
埋込み型人工心筋装置による補助循環の際の血行動態に関する検討 Peer-reviewed

王慶田, 山家智之, 白石泰之, 西條芳文, 梅津光生, 仁田新一

人工臓器　34　(2)　S-122　2005/11
超微細径アクチュエータを用いたメカトロニクス心筋の開発 Peer-reviewed

白石泰之, 山家智之, 関根一光, 金野敏, 西條芳文, 王慶田, 劉紅箭, 仁田新一, 佐藤文博, 小川大祐, 田中明, 吉澤誠, 岡本英治, 永利潤, 伊藤慎二, 植松美幸, 梅津光生, 田林晄一, 増本憲泰, 藤本哲男

人工臓器　34　(2)　S-122　2005/11
コイル状形状記憶合金による蠕動運動型人工食道の開発 Peer-reviewed

関根一光, 山家智之, 西條芳文, 白石泰之, 堀義生, 松木英敏, 佐藤文博, 角張泰之, 三浦英和, 前田剛, 仁田新一

人工臓器　34　(2)　S-116　2005/11

ISSN： 0300-0818
粘弾性効果を考慮したin vivoにおける大腸の力学的特性評価試験 Peer-reviewed

比嘉昌, 羅雲, 奥山武志, 高木敏行, 白石泰之, 山家智之

人工臓器　34　(2)　S-95　2005/11
日本の人工臓器研究・開発に望まれるもの冠動脈バイパスグラフトの術中評価(マルチポイントドプラ法)機器の開発 Peer-reviewed

新田能郎, 西條芳文, 白石泰之, 山家智之, 若松立也, 田中元直, 田林晄一

人工臓器　34　(2)　S-49　2005/11
Publisher:
DOI： 10.11392/jsao1972.34.2Supplement_s49 　

ISSN： 0300-0818
Development of the pulsation device for rotary blood pumps Peer-reviewed

T Yambe, Y Shiraishi, K Sekine, M Shibata, T Yamaguchi, LH Jian, M Yoshizawa, A Tanaka, H Matsuki, F Sato, Y Haga, M Esashi, K Tabayashi, Y Mitamura, H Sasada, S Nitta

ARTIFICIAL ORGANS　29　(11)　912-915　2005/11

DOI： 10.1111/j.1525-1594.2005.00159.x 　

ISSN： 0160-564X
Chaos analysis of electro encephalography and control of seizure attack of epilepsy patients Peer-reviewed

T Yambe, E Asano, S Mauyama, Y Shiraishi, M Shibata, K Sekine, M Watanabe, T Yamaguchi, M Shibata, T Kuwayama, S Konno, S Nitta

BIOMEDICINE & PHARMACOTHERAPY　59　S236-S238　2005/10

DOI： 10.1016/S0753-3322(05)80038-1 　

ISSN： 0753-3322
Cardio-ankle vascular index (CAVI) for the monitoring of the atherosclerosis after heart transplantation Peer-reviewed

T Yambe, Meng, X, Hou, X, Q Wang, K Sekine, Y Shiraishi, M Watanabe, T Yamaguchi, M Shibata, T Kuwayama, M Maruyama, S Konno, S Nitta

BIOMEDICINE & PHARMACOTHERAPY　59　S177-S179　2005/10

DOI： 10.1016/S0753-3322(05)80028-9 　

ISSN： 0753-3322
Effect of the alternative magnetic stimulation on peripheral circulation for regenerative medicine Peer-reviewed

T Yambe, A Inoue, K Sekine, Y Shiraishi, A Watanabe, T Yamaguchi, M Shibata, A Maruyama, S Konno, S Nitta

BIOMEDICINE & PHARMACOTHERAPY　59　S174-S176　2005/10

DOI： 10.1016/S0753-3322(05)80027-7 　

ISSN： 0753-3322
異なる2つのタイプの分岐型人工血管のPWVを用いた比較,検討 Peer-reviewed

岩橋徹, 内山裕智, 中村慶太, 佐藤和弘, 小泉信達, 小櫃由樹生, 白石泰之

脈管学　45　(10)　798-798　2005/10
マルチポイントドプラによる冠動脈バイパスグラフト吻合部の術中評価法の開発 Peer-reviewed

新田能郎, 白石泰之, 西條芳文, 山家智之, 若松立也, 田中元直, 田林晄一

The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY　53　(Suppl.II)　336-336　2005/09
【消化管とナノテクノロジー医療】ナノバイオマテリアルを応用した人工食道の開発 Peer-reviewed

山家智之, 堀義生, 渡辺誠, 白石泰之, 井口篤志, 田林晄一, 芳賀洋一, 江刺正喜, 吉澤誠, 田中明, 松木英敏, 佐藤文博, 川野恭之, 羅雲, 高木敏行, 早瀬敏幸, 圓山重直, 仁田新一, 佐々田比呂志, 佐藤英明, 本間大, 前田剛

G.I.Research　13　(4)　271-276　2005/08
完全埋込型心室補助装置による循環補助 Peer-reviewed

白石泰之, 山家智之, 関根一光, 西條芳文, 堀義生, 桑山貴志, 小川大祐, 田中明, 吉澤誠, 佐藤文博, 松木英敏, 羅雲, 高木敏行, 比嘉昌, 伊吹竜太, 圓山重直, 岡本英治, 青木秀宜, 永利潤, 伊藤慎二, 梅津光生, 佐々田比呂志, 王慶田, 段旭東, 劉紅箭, 仁田新一, 田林晄一

生体医工学　43　(2)　328-328　2005/06
テーパー型とストレート型グラフトの血流量に関する実験的研究 Peer-reviewed

内野敬, 白石泰之, 東仲宣, 佐々木司

日本透析医学会雑誌　38　(Suppl.1)　757-757　2005/05
ナノバイオマテリアルを応用した人工食道の開発 Peer-reviewed

山家智之, 堀義生, 渡辺誠, 白石泰之, 井口篤志, 田林晄一, 芳賀洋一, 江刺正喜, 吉澤誠, 田中明, 松木英敏, 佐藤文博, 川野恭之, 羅雲, 高木敏行, 早瀬敏幸, 圓山重直, 仁田新一, 佐々田比呂志, 佐藤英明, 本間大, 前田剛

Journal of Gastrointentional Research　13　(4)　19-24　2005/04
拍動のない循環における血圧反射と自律神経機能 Peer-reviewed

山家智之, 吉澤誠, 白石泰之, 田林晄一, 関根一光

自律神経　42　(2)　206-206　2005/04
動脈硬化と心理行動スケールパラメータの関連性 Peer-reviewed

山家智之, 洪蘭, 仁田新一, 白石泰之, 段旭東, 金野敏, 渡辺誠, 王慶田, 桑山貴志, 関根一光, 劉紅箭, 田林晄一

自律神経　42　(2)　193-193　2005/04
Artificial esophagus with peristaltic movement Peer-reviewed

M Watanabe, K Sekine, Y Hori, Y Shiraishi, T Maeda, D Honma, G Miyata, Y Saijo, T Yambe

ASAIO JOURNAL　51　(2)　158-161　2005/03

DOI： 10.1097/01.MAT.0000154644.44891.F1 　

ISSN： 1058-2916
様々な負荷に対する心機能変化計測への試み

植松美幸, 白石泰之, 関根一光, 山家智之, 西條芳文, 武藤俊介, 朴栄光, 安藤隼人, 松本徹, 武田朴, 岩崎清隆, 梅津光生, 内山明彦

電気学会研究会資料　23-26　2005/02
Development of an artificial myocardium using a covalent shape-memory alloy fiber and its cardiovascular diagnostic response

Y. Shiraishi, T. Yambe, K. Sekine, N. Masumoto, J. Nagatoshi, S. Itoh, Y. Saijo, Q. Wang, H. Liu, S. Nitta, S. Konno, D. Ogawa, P. Olegario, M. Yoshizawa, A. Tanaka, F. Sato, Y. Park, M. Uematsu, M. Higa, Y. Hori, T. Fujimoto, K. Tabayashi, H. Sasada, M. Umezu, D. Homma

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings　7 VOLS　406-408　2005

DOI： 10.1109/iembs.2005.1616431 　

ISSN： 0589-1019
508 Development of a totally implantable artificial myocardial assist system : Preliminary study of the hemodynamic effect in the mock circulatory system and in animal experiment

AOKI Hidetaka, NITTA Shin-ichi, OKAMOTO Eiji, OGAWA Daisnke, YOSHIZAWA Makoto, TANAKA Akira, TANAKA Takashi, SASADA Hiroshi, TABAYASHI Koichi, HOMMA Dai, NAGATOSHI Jun, ITOH Shinji, SUDO Tomohiro, UMEZU Mitsuo, SHIRAISHI Yasuyuki, SEKINE Kazumitsu, SAIJO Yoshifumi, YAMBE Tomoyuki

Proceedings of the JSME Bioengineering Conference and Seminar　2004　(0)　191-192　2005
Publisher: 一般社団法人日本機械学会
DOI： 10.1299/jsmebs.2004.17.0_191 　
Non-blood contacting electro-hydraulic artificial myocardium (EHAM) improves the myocardial tissue perfusion Peer-reviewed

Qingtian Wang, Tomoyuki Yambe, Yasuyuki Shiraishi, Xudong Duan, Makoto Yoshizawa, Kouichi Tabayashi, Shinichi Nitta, Mitsuo Umezu

Technology and Health Care　13　(4)　229-234　2005

ISSN： 0928-7329
Development of an artificial myocardium using a covalent shape-memory alloy fiber and its cardiovascular diagnostic response Peer-reviewed

Y. Shiraishi, T. Yambe, K. Sekine, N. Masumoto, J. Nagatoshi, S. Itoh, Y. Saijo, Q. Wang, H. Liu, S. Nitta, S. Konno, D. Ogawa, P. Olegario, M. Yoshizawa, A. Tanaka, F. Sato, Y. Park, M. Uematsu, M. Higa, Y. Hori, T. Fujimoto, K. Tabayashi, H. Sasada, M. Umezu, D. Homma

2005 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-7　1　(1)　406-408　2005

ISSN： 1094-687X
An innovative approach to evaluate a cardiac function based on surface measurement Peer-reviewed

M. Uematsu, Y. Shiraishi, K. Sekine, T. Yambe, Y. Saijo, Y. Park, H. Ando, T. Matsumoto, S. Takeda, K. Iwasaki, M. Umezu

2005 27TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-7　7　7640-7643　2005

ISSN： 1094-687X
形状記憶合金を用いた蠕動運動型人工食道の開発 Peer-reviewed

関根一光, 山家智之, 西條芳文, 白石泰之

加齢医学研究所雑誌　56　(1)　37-37　2004/11
Addition of rhythm to non-pulsatile circulation Peer-reviewed

T Yambe, K Sekine, Y Shiraishi, M Watanabe, M Shibata, T Yamaguchi, QT Wang, XD Duan, HJ Liu, M Yoshizawa, A Tanaka, H Matsuki, F Sato, YI Haga, M Esashi, K Tabayashi, Y Mitamura, H Sasada, E Sato, Y Saijo, S Nitta

BIOMEDICINE & PHARMACOTHERAPY　58　S145-S149　2004/10

DOI： 10.1016/S0753-3322(04)80024-6 　

ISSN： 0753-3322
A Japanese-Russian collaborative study on aging and atherosclerosis Peer-reviewed

T Yambe, YA Kovalev, IA Milyagina, VA Milyagin, Y Shiraishi, M Yoshizawa, Y Saijo, T Yamaguchi, M Shibata, S Nitta

BIOMEDICINE & PHARMACOTHERAPY　58　S91-S94　2004/10

DOI： 10.1016/S0753-3322(04)80014-3 　

ISSN： 0753-3322
Development of an implantable undulation type ventricular assist device for control of organ circulation Peer-reviewed

T Yambe, Y Abe, K Imachi, Y Shiraishi, MI Shibata, T Yamaguchi, QT Wang, XD Duan, HJ Liu, M Yoshizawa, A Tanaka, H Matsuki, F Sato, YI Haga, M Esashi, K Tabayashi, Y Mitamura, H Sasada, M Umezu, T Matsuda, SI Nitta

ARTIFICIAL ORGANS　28　(10)　940-944　2004/10

DOI： 10.1111/j.1525-1594.2004.07382.x 　

ISSN： 0160-564X
Component engineering for an implantable system Peer-reviewed

QT Wang, T Yambe, Y Shiraishi, M Esashi, Y Haga, M Yoshizawa, F Sato, H Matsuki, K Imachi, Y Abe, H Sasada, S Nitta

ARTIFICIAL ORGANS　28　(10)　869-873　2004/10

DOI： 10.1111/j.1525-1594.2004.07383.x 　

ISSN： 0160-564X
硬膜下脳波モニタリング波形のカオス解析による癲癇の発生予測 Peer-reviewed

山家智之, 浅野英司, 柴田宗一, 白石泰之

日本臨床生理学会雑誌　34　(臨増)　69-69　2004/10
最新のテクノロジーナノテク人工心筋による心不全治療 Peer-reviewed

山家智之, 白石泰之, 田林晄一

日本臨床生理学会雑誌　34　(臨増)　49-49　2004/10
拍動のない循環における血圧反射と自律神経機能 Peer-reviewed

山家智之, 吉澤誠, 白石泰之, 田林晄一, 関根一光

日本自律神経学会総会57回プログラム・抄録集　96-96　2004/10
動脈硬化と心理行動スケールパラメータの関連性 Peer-reviewed

山家智之, 洪蘭, 仁田新一, 白石泰之, 段旭東, 金野敏, 渡辺誠, 王慶田, 桑山貴志, 関根一光, 劉紅箭, 田林晄一

日本自律神経学会総会57回プログラム・抄録集　79-79　2004/10
Effect of the elastic conditions around a stentless valvular bioprosthesis on opening behavior Peer-reviewed

Tetsuo Fujimoto, Daisuke Kawaguchi, Yasuyuki Shiraishi, Kiyotaka Iwasaki, Makoto Arita, Takashi Tanaka, Mitsuo Umezu

Journal of Artificial Organs　7　(3)　133-136　2004/09

DOI： 10.1007/s10047-004-0262-z 　

ISSN： 1434-7229
An artificial myocardium assist system: Electrohydraulic ventricular actuation improves myocardial tissue perfusion in goats Peer-reviewed

QT Wang, T Yambe, Y Shiraishi, XD Duan, S Nitta, K Tabayashi, M Umezu

ARTIFICIAL ORGANS　28　(9)　853-857　2004/09

DOI： 10.1111/j.1525-1594.2004.0004.x 　

ISSN： 0160-564X
形状記憶合金「バイオメタル」を用いた蠕動運動型人工食道の開発研究 Peer-reviewed

関根一光, 山家智之, 西條芳文, 白石泰之, 堀義生, 松木英敏, 佐藤文博, 本間大, 前田剛

人工臓器　33　(2)　S221-S221　2004/09
再生医療を超えるナノテク人工心筋を目指して Peer-reviewed

山家智之, 白石泰之, 関根一光, 田林晄一, 高木敏行, 圓山重直, 羅雲, 比嘉昌, 堀義生

人工臓器　33　(2)　S194-S194　2004/09
完全埋込を目指した人工心室補助装置の血行力学的影響慢性動物実験における心収縮補助効果の検討 Peer-reviewed

白石泰之, 山家智之, 岡本英治, 関根一光, 小川大祐, ポール・オレガリオ, 吉澤誠, 青木秀宜, 永利潤, 伊藤慎二, 田中明, 佐藤文博, 西條芳文, 王慶田, 圓山重直, 早瀬敏幸, 松木英敏, 本間大, 梅津光生, 仁田新一

人工臓器　33　(2)　S193-S193　2004/09
血液循環シミュレーションモデルによる透析シャント用ePTFE人工血管の拍動抵抗特性の検討 Peer-reviewed

白石泰之, 関根一光, 山家智之, 西條芳文, 青木秀宜, 梅津光生, 藤本哲男, 内野敬

人工臓器　33　(2)　S172-S172　2004/09
完全置換型定常流人工心臓における流量・差圧推定法および推定値に基づく制御系のin vivo評価 Peer-reviewed

小川大祐, 吉澤誠, 阿部健一, 田中明, OlegarioPaul, 花岡哲文, 白石泰之, 山家智之, 仁田新一

人工臓器　33　(2)　S149-S149　2004/09
キチン・スキャフォールドを用いた自己組織再生誘導型人工食道の試み Peer-reviewed

堀義生, 関根一光, 白石泰之, 山家智之

人工臓器　33　(2)　S138-S138　2004/09
キチン(ポリ-N-アセチルグルコサミン)不織布を応用した,自己組織再生誘導型人工食道の大動物モデルにおける検討 Peer-reviewed

堀義生, 桜井直, 関根一光, 白石泰之, 里見進, 山家智之

炎症・再生　24　(4)　488-488　2004/07
形状記憶合金の代用臓器アクチュエータへの応用 Peer-reviewed

山家智之, 白石泰之, 羅雲, 高木敏行, 円山重直, 前田剛, 本間大

北海道外科雑誌　49　(1)　98-99　2004/06
機械式心室補助システムの開発 Invited Peer-reviewed

白石泰之

加齢医学研究所雑誌　55　(1)　24-25　2004/03
補助循環

下野高嗣, 白石泰之, 田岡誠, 有賀睦, 山家智之, 枝州浩, 秦光賢, 横井健人

人工臓器　33　(2)　s193-s196　2004
Publisher: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS
DOI： 10.11392/jsao1972.33.2Supplement_s193 　

ISSN： 0300-0818
人工弁

岩崎清隆, 西村和修, 白石泰之, 岡本英治, 有田誠

人工臓器　33　(1)　91-96　2004
Publisher: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS
DOI： 10.11392/jsao1972.33.91 　

ISSN： 0300-0818
Dynamic response of the pulmonary circulation in continuous flow artificial heart systems

P. S. Olegario, M. Yoshizawa, A. Tanaka, Y. Shiraishi, D. Ogawa, T. Hanaoka, K. Abe, T. Yambe, S. Nitta

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings　26 V　3777-3780　2004

DOI： 10.1109/iembs.2004.1404059 　

ISSN： 0589-1019
Dynamic response of the pulmonary circulation in a continuous flow artificial heart system

P. S. Olegario, M. Yoshizawa, A. Tanaka, Y. Shiraishi, D. Ogawa, T. Hanaoka, K. Abe, T. Yambe, S. Nitta

Proceedings of the SICE Annual Conference　1735-1738　2004
Control of continuous flow artificial heart using estimated flow rate and pressure head

Daisuke Ogawa, Makoto Yoshizawa, Akira Tanaka, Paul Olegario, Tetsubumi Hanaoka, Yasuyuki Shiraishi, Tomoyuki Yambe, Shin Ichi Nitta

Proceedings of the SICE Annual Conference　2893-2896　2004
Dynamic response off the pulmonary circulation in continuous flow artificial heart systems Peer-reviewed

PS Olegario, M Yoshizawa, A Tanaka, Y Shiraishi, D Ogawa, T Hanaoka, K Abe, T Yambe, S Nitta

PROCEEDINGS OF THE 26TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-7　26　3777-3780　2004

DOI： 10.1109/IEMBS.2004.1404059 　

ISSN： 1094-687X
In vitro evaluating system for prosthetic heart valves

Fujimoto T, Tsutsumi Y, Kawaguchi D, Shiraishi Y, Iwasaki K, Arita M, Umezu M

芝浦工業大学学術フロンティア推進事業2002年度研究成果報告　17-26　2003/12
Recording vagal nerve activity for the control of an artificial heart system Peer-reviewed

T Yambe, SS Nanka, Y Shiraishi, A Tanaka, M Yoshizawa, K Abe, K Tabayashi, H Takeda, S Nitta

ASAIO JOURNAL　49　(6)　698-700　2003/11

DOI： 10.1097/01.MAT.0000094193.21479.91 　

ISSN： 1058-2916
Artificial myocardium with an artificial baroreflex system using nano technology Peer-reviewed

T Yambe, Y Shiraishi, M Yoshizawa, A Tanaka, K Abe, F Sato, H Matsuki, M Esashi, Y Haga, S Maruyama, T Takagi, Y Luo, E Okamoto, Y Kubo, M Osaka, S Nanka, Y Saijo, Y Mibiki, T Yamaguchi, M Shibata, S Nitta

BIOMEDICINE & PHARMACOTHERAPY　57　122S-125S　2003/10

DOI： 10.1016/j.biopha.2003.08.016 　

ISSN： 0753-3322

eISSN： 1950-6007
人工心筋駆動時の心拍ゆらぎ解析に基づき生体の自律神経への影響 Peer-reviewed

段旭東, 白石泰之, 王慶田, 山家智之, 仁田新一, 田中明, 吉澤誠, 柴田宗一, 西條芳文, 小川大介

人工臓器　32　(2)　S149-S149　2003/09
機械式人工心筋の開発心補助効果と生体心臓との力学的相互作用の基礎検討 Peer-reviewed

白石泰之, 岡本英治, 山家智之, 段旭東, 王慶田, 柴田宗一, 田中明, 小川大祐, 吉澤誠, 西條芳文, 仁田新一, 青木秀宜, 永利潤, 川合潤子, 末弘淳一, 吉田敬, 梅津光生, 井口篤志, 田林晄一, 圓山重直, 早瀬敏幸

人工臓器　32　(2)　S149-S149　2003/09
遠心ポンプ型補助人工心臓EVAHEARTのin vitro耐久性試験 Peer-reviewed

北野智哉, 得能敏正, 金子恵一, 牛山博之, 山崎健二, 木原信一郎, 梅津光生, 白石泰之

人工臓器　32　(2)　S143-S143　2003/09
Y字型人工血管における分岐管径と圧力損失に関する基礎的検討 Peer-reviewed

藤本哲男, 大橋勇史, 新井邦明, 白石泰之, 梅津光生, 岩村弘志

人工臓器　32　(2)　S83-S83　2003/09
RISK AND BENEFITのバランス感覚を支える人工臓器のIN VITRO性能評価のあり方 Peer-reviewed

梅津光生, 岩崎清隆, 白石泰之, 有田誠, 堀切芳一, 田中隆, 馮忠剛, 藤本哲男, 桜井靖久

人工臓器　32　(2)　S16-S16　2003/09
ナノテク集積人工心筋開発プロジェクト Peer-reviewed

山家智之, 白石泰之, 井口篤志, 田林晄一, 芳賀洋一, 江刺正喜, 吉澤誠, 田中明, 松木英敏, 佐藤文博, 川野恭之, 羅雲, 高木敏行, 早瀬敏幸, 圓山重直, 王慶田, 段旭東, 仁田新一, 岡本英治, 久保豊, 大坂元久, 梅津光生

循環制御　24　(2)　111-117　2003/06

ISSN： 0389-1844
日露共同研究日本人とロシア人の健常者における脈波伝播速度比較 Peer-reviewed

山家智之, 薗部太郎, 白石泰之, 段旭東, 仁田新一, ユーリ・A・コバレフ, ビクター・A・ミラーゲン

エレクトロニクスの臨床　(74)　59-69　2003/06
ナノテク集積インテリジェント人工心筋の開発研究 Peer-reviewed

山家智之, 吉澤誠, 田林晄一, 圓山重直, 白石泰之

循環制御　24　(Suppl.)　46-46　2003/05
未来医学事典バイオ・マイクロ・マニピュレータとその応用 Invited

白石泰之

未来医学　(18)　70-73　2003/02
Publisher:
ISSN： 0910-9870
Autonomic Nervous System and Oxygen Metabolism of the Brain during Bathing

Tomoyuki Yambe, Naoki Owada, Yasuyuki Shiraishi, Makoto Yoshizawa, Akira Tanaka, Ken-Ichi Abe, Mune-Ichi Shibata, Tasuku Yamaguchi, Xudong Duan, Shu Wie, Hiroshi Sasada, Shinichi Nitta

Therapeutic Research　24　(11)　2027-2031　2003

ISSN： 0289-8020
補助循環4

高本眞一, 筒井達夫, 白石泰之, 段旭東, 王慶田, 宇野澤聡, 米川彰

人工臓器　32　(2)　s149-s151　2003
Publisher: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS
DOI： 10.11392/jsao1972.32.2Supplement_s149 　

ISSN： 0300-0818
ステントレス生体弁周囲の弾性力学的条件が弁開放特性に及ぼす影響 Peer-reviewed

藤本哲男, 川口大輔, 白石泰之, 岩崎清隆, 有田誠, 梅津光生

人工臓器　31　(2)　S199-S199　2002/09
新しいY字型人工血管の開発と基礎特性の工学的検討 Peer-reviewed

白石泰之, 岩村弘志, 齋藤勇二, 青木秀宣, 渡邊聡亮, 梅津光生, 大橋勇史, 藤本哲郎

人工臓器　31　(2)　S196-S196　2002/09
In vitro evaluating system for prosthetic heart valves in a case of the Jyros Valve Peer-reviewed

Fujimoto T, Tsutsumi Y, Shiraishi Y Iwasaki, K, Yoshida M, Umezu M Begg, J, Woodard J

Biocybernetics and Biomedical Engineering　22　(4)　41-46　2002/04
Left ventricle simulator for surgeons’ support Peer-reviewed

Umezu M Arita M, Iwasaki K, Shiraishi Y Tono, S, Uchida K

Biocybernetics and Biomedical Engineering　22　(4)　47-53　2002/04
Development of a mechanical circulatory system for the evaluation of dynamic characteristics of descending aortic bifurcation graft

SAITO Yuji, SHIRAISHI Yasuyuki, IWAMURA Hiroshi, OHASHI Hayafumi, AOKI Hidetaka, WATANABE Toshiaki, TAKEO Satoshi, ARAI Kuniaki, FUJIMOTO Tetsuo, UMEZU Mitsuo

Proceedings of the JSME Bioengineering Conference and Seminar　2002　77-78　2002
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebs.2002.13.0_77 　
機械式人工弁の弁葉回転と溶血に関する比較的検討 Peer-reviewed

藤本哲男, 堤祐一, 白石泰之, 岩崎清隆, 梅津光生

人工臓器　29　(3)　S-119　2000/08
日本発の人工臓器研究開発には何が必要か人工臓器の安全性・有効性評価の科学的方法論の確立 Peer-reviewed

梅津光生, 白石泰之, 有田誠, FengZG, 岩崎清隆, 吉田正徳, 藤本哲男

人工臓器　29　(3)　S-17　2000/08
Publisher:
DOI： 10.11392/jsao1972.29.3Supplement_s16 　

ISSN： 0300-0818
大動脈人工血管置換前後の血管系負荷要素の定量比較の試み Peer-reviewed

白石泰之, 有田誠, 梅津光生, 藤本哲男, 石橋和幸, 川副浩平

人工臓器　29　(3)　S-105　2000/08
Viscoelastic characteristics of artificial arteries in a Waseda Mock Circulatory System Peer-reviewed

Shiraishi Y, Umezu M, Fujimoto T, Teoh SH

Proc of 10th International Conference of Biomedical Engineering　-　(-)　287-288　2000/04
高速ビデオカメラを用いた人工弁の回転に関する検討 Peer-reviewed

藤本哲男, 比留間信義, 堤祐一, 岩崎清隆, 白石泰之, 梅津光生, BeggJohn, WoodardJohn

人工臓器　29　(1)　117-120　2000/02
Publisher: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS
DOI： 10.11392/jsao1972.29.117 　

ISSN： 0300-0818

More details Close

The Jyros valve, the leaflets of which can be rotated in an orifice ring by spiral flow, was also shown to have the unique characteristic of less energy loss than that of other types of valves. This study was carried out to further examine precise hydrodynamic characteristics of the valve. The Jyros valve was placed at the aortic position of a spiral vortex pump (SV pump) fixed in a mock circuit. Pressure gradient at the valve was measured with pressure transducers. Another experiment was conducted under the same conditions, in which we fixed its leaflets in place so that they could not rotate within the ring (fixed Jyros). In addition, the movement of the valve was analyzed with a high speed video camera. The results from these experiments were as follows: (1) The valve leaflet rotation occurs at the late systolic phase, when the valve begins closing, and (2) during this phase, pressure gradient at the valve was lower by 3 mmHg compared to the fixed valve under usual drive conditions. Based on the above results, the valve rotation is shown to reduce flow resistance under the rotational flow condition.
Fluctuations of the cardiac function with extraanatomical bypass in dogs

Ishibashi, K., Shiraishi, Y., Umezu, M., Kawazoe, K.

ASAIO Journal　46　(2)　203-203　2000

DOI： 10.1097/00002480-200003000-00212 　

ISSN： 1058-2916
高速ビデオカメラを用いた人工弁の回転に関する検討 Peer-reviewed

藤本哲男, 比留間信義, 堤祐一, 白石泰之, 梅津光生, BeggJohn, WoodardJohn

人工臓器　28　(4)　S77-S77　1999/09
人工血管置換前後の左室ポンプ負荷の力学的変動 Peer-reviewed

白石泰之, 石橋和幸, 有田誠, 藤本哲男, 梅津光生, 川副浩平

人工臓器　28　(4)　S92-S92　1999/09
旋回流における各種人工弁のエネルギ損失の比較 Peer-reviewed

藤本哲男, 比留間信義, 白石泰之, 梅津光生, BeggJohn, WoodardJohn

人工臓器　27　(4)　S-81　1998/09
人工血管の新しい評価法に関する研究 Peer-reviewed

白石泰之, 藤本哲男, 梅津光生, 川副浩平

人工臓器　27　(4)　S-128　1998/09
Improvement of an aortic region in a mock circulatory system verified from goat experiment Peer-reviewed

Shiraishi Y, Fujimoto T, Arakawa M, Yamasaki, K, Yamasaki F, Hotta Y, Umezu M, Yambe, T, Nitta S

Proc. of 9th International Conference of Biomedical Engineering　-　(-)　363-365　1998/04
機械式人工弁における開放特性のディスク形状による比較検討 Peer-reviewed

藤本哲男, 真木康隆, 白石泰之

人工臓器　27　(1)　158-163　1998/02

DOI： 10.11392/jsao1972.27.158 　
Comparison of opening behaviors of monoleaflet tilting disc valves using a high speed video camera

Fujimoto, T., Maki, Y., Shiraishi, Y., Umezu, M., Naemura, K., Akutsi, T.

Japanese Journal of Artificial Organs　27　(1)　1998

ISSN： 0300-0818
人工臓器の試験を目的とした循環系モデルにおける動脈系の再現性(第2報) 脈波伝播特性を中心とした生体との比較 Peer-reviewed

藤本哲男, 白石泰之, 梅津光生

人工臓器　25　(1)　31-34　1996/02
Publisher:
DOI： 10.11392/jsao1972.25.31 　

ISSN： 0300-0818
An experiment on aortic pressure wave in a mechanical ciculatory system

Fujimoto, T., Shiraishi, Y., Umezu, M.

Japanese Journal of Artificial Organs　25　(1)　1996

ISSN： 0300-0818
Regional myocardial behaviour cardiac surface under arrhythmic conditions

Uematsu M, Shiraishi Y, Sekine K, Yambe T, Saijo Y, Ando H, Park Y, Takeda S, Iwasaki K, Umezu M

Proceedings of 12th International Conference on Biomedical Engineering　12　1A5-05

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Misc. 231

LSTMネットワークを用いた補助人工心臓運用時の大動脈弁開閉動作のリアルタイム推定

鈴木竜弥, 田中明, 吉澤誠, 白石泰之, 山家智之

日本生体医工学会大会プログラム・抄録集(Web)　63rd　2024
Development of a compact percutaneous direct ventricular puncture type blood pump

FRANCIS Chikweto, FUKAI Miharu, FUKAYA Aoi, SHIRAISHI Yasuyuki, YAMBE Tomoyuki, KIJIMA Toshihiko, HORIE Hideyuki, ISHIYAMA Kazushi

人工臓器(日本人工臓器学会)　52　(2)　2023

ISSN： 0300-0818
補助人工心臓装着時の状態空間モデルを用いた循環パラメータの同定と弁の開閉動作の推定

下川柚依, 田中明, 吉澤誠, 白石泰之, 山家智之

人工臓器(日本人工臓器学会)　51　(2)　2022

ISSN： 0300-0818
補助人工心臓の任意のポンプ特性を実現する拍内制御

八巻大祐, 田中明, 吉澤誠, 白石泰之, 山家智之

人工臓器(日本人工臓器学会)　51　(2)　2022

ISSN： 0300-0818
補助人工心臓のインペラの非対称性を利用した拡張期の逆流検出と拍動制御

サワリナタンジョセリンアン, 田中明, 吉澤誠, 白石泰之, 山家智之

人工臓器(日本人工臓器学会)　51　(2)　2022

ISSN： 0300-0818
連続流型補助人工心臓における拡張期の逆流検出と完全拍動制御

サワリナタンジョセリンアン, 田中明, 吉澤誠, 白石泰之, 山家智之

人工臓器(日本人工臓器学会)　50　(2)　2021

ISSN： 0300-0818
補助人工心臓運の拍動同期制御を利用した大動脈弁逆流の検出

丹治洸太郎, 田中明, 吉澤誠, 白石泰之, 山家智之

人工臓器(日本人工臓器学会)　50　(2)　2021

ISSN： 0300-0818
Evaluation of the Effects of the Changes in Flow Channel Deformation by Cyclic Loading on Blood Flow Characteristics in a Roller Pump Model Peer-reviewed

ライフサポート　33　(2)　52-58　2021
Publisher: ライフサポート学会
ISSN： 1341-9455
埋め込み型医療機器の信頼性とEN45502 : EN45502 医療機器のEMC規格最新動向

山家智之, 白石泰之, 井上雄介, 山田昭博

EMC : electro magnetic compatibility : solution technology : 電磁環境工学情報　33　(4)　107-125　2020/08
Publisher: つくば : [科学情報出版]
ISSN： 0916-2275
非線形ARXモデルを用いた補助人工心臓装着時の循環系パラメータの逐次同定と大動脈弁動作の推定

平木倫, 田中明, 吉澤誠, 白石泰之, 山家智之

人工臓器(日本人工臓器学会)　49　(3)　2020

ISSN： 0300-0818
大動脈弁閉鎖不全時に補助人工心臓の制御様式が弁逆流に与える影響

丹治洸太郎, 田中明, 吉澤誠, 白石泰之, 山家智之

人工臓器(日本人工臓器学会)　49　(3)　2020

ISSN： 0300-0818
畳み込みニューラルネットワークを用いた左心補助人工心臓装着時の大動脈弁開閉動作の推定

中谷修士, 田中明, 吉澤誠, 白石泰之, 山家智之

人工臓器(日本人工臓器学会)　49　(3)　2020

ISSN： 0300-0818
ステントグラフト治療後の反射波増加は大動脈径に依存する:ヤギ実験モデルにおけるwave intensityの評価

高野智弘, 高野真澄, 高野真澄, 坪子侑佑, 坪子侑佑, 白石泰之, 山家智之, 横山斉

脈管学(Web)　60　(supplement)　2020

ISSN： 1880-8840
微細管路系による流体剪断負荷とvon Willebrand factor損傷に関する特性評価の基礎検討

舘崎祐馬, 白石泰之, 井上雄介, 山田昭博, 岩元直樹, 盛田良介, Ibadurrahman Ahmad Faiz, 橋本真登香, 堀内久徳, 早川正樹, 松本雅則, 萱島道徳, 山家智之

人工臓器　48　(2)　S-241　2019/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
「お年寄りの気持ちを理解する」世界で初めての医療・看護・福祉共通プラットフォーム

山家智之, 白石泰之, 山田昭博

研究結果報告書集 : 交通事故・各種災害の防止等分野・高齢者福祉分野　25　87-90　2019
Publisher: 東京 : 三井住友海上福祉財団
補助人工心臓装着時循環系の主要な循環パラメータの逐次同定と大動弁開閉動作の推定

平木倫, 田中明, 吉澤誠, 白石泰之, 山家智之

人工臓器(日本人工臓器学会)　48　(2)　2019

ISSN： 0300-0818
補助人工心臓治療の血液凝固関連における新知見高せん断応力とフォンウィルブランド因子に関する基礎研究

井上雄介, 早川正樹, 松本雅則, 堀内久徳, 山田昭博, 白石泰之, 軽部雅人, 源田達也, 岩元直樹, 舘崎祐馬, 盛田良介, 山家智之

人工臓器　47　(2)　S-30　2018/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818
高ひずみ剪断流体のVWF損傷評価用往復動流体試験システムの開発

舘崎祐馬, 白石泰之, 井上雄介, 山田昭博, 軽部雅人, 源田達也, 岩元直樹, 盛田良介, 堀内久徳, 松本雅則, 早川正樹, 山家智之

人工臓器　47　(2)　S-167　2018/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818
補助人工心臓治療の血液凝固関連における新知見高せん断応力とフォンウィルブランド因子に関する基礎研究

井上雄介, 早川正樹, 松本雅則, 堀内久徳, 山田昭博, 白石泰之, 軽部雅人, 源田達也, 岩元直樹, 舘崎祐馬, 盛田良介, 山家智之

人工臓器　47　(2)　S-30　2018/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818
高ひずみ剪断流体のVWF損傷評価用往復動流体試験システムの開発

舘崎祐馬, 白石泰之, 井上雄介, 山田昭博, 軽部雅人, 源田達也, 岩元直樹, 盛田良介, 堀内久徳, 松本雅則, 早川正樹, 山家智之

人工臓器　47　(2)　S-167　2018/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818
Examination of hydrodynamic resistance of a paediatric Fontan regulation clip device

KARUBE MASATO, Shiraishi Yasuyuki, Yamada Akihiro, Inoue Yusuke, Genda Tatuya, Yamagisi Masaaki

Transactions of Japanese Society for Medical and Biological Engineering　56　(0)　S319-S319　2018
Publisher: Japanese Society for Medical and Biological Engineering
ISSN： 1347-443X

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We have been developing a dynamic flow regulation clip for Fontan circulation to eliminate backflow during the exhalation phase in the patients with congenital heart failure. The clip has been designed to increase hydrodynamic resistance through the bypass from the inferior vena cava to pulmonary artery during the respiration. The mechanism of the resistance change is to be controlled from outside of the graft by the contraction of shape memory alloy fibers. In this study, we developed a mock circulation system simulating backflow of Fontan circulation using a linear actuation mechanism for respiratory hydrodynamic pressure changes. Consequently, it was suggested that the control parameter and the resistance values of Fontan regulation clip could be obtained.
Control of angiogenesis using electrical stimulation for implantable sensor

INOUE YUSUKE, SAITO ITSURO, ISOYAMA TAKASHI, ABE YUSUKE, YAMBE TOMOYUKI, YOKOTA TOMOYUKI, GENDA TATSUYA, SHIRAISHI YASUYUKI, YAMADA AKIHIRO, TAIRA YASUNORI, ARAKAWA TOMOYA, YUBA MITSURU, KARUBE MASATO

Transactions of Japanese Society for Medical and Biological Engineering　56　(0)　S287-S287　2018
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.52.O-249 　

ISSN： 1347-443X

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The purpose of this study is to observe angiogenesis in vivo under application of electric stimulations. We developed an implantable device equipped with a CMOS-camera and electrodes for real-time observation. The device was implanted under the skin of a goat, and applied the electric stimulations for 60 days. The electric stimulations were applied with a 60 kHz sinusoidal waveform and a current density of 300 uA/mm2. Angiogenesis occurred in 94.7um/day in the non-stimulated device, while no angiogenesis was observed in the device without stimulation. These results show that electric stimulations of this condition are effective for suppressing angiogenesis.
胸部および腹部大動脈ステントグラフト内挿術の心血管機能に及ぼす影響

高野智弘, 白石泰之, 荒川友哉, 坪子侑佑, 高野真澄, 横山斉

福田記念医療技術振興財団情報　(30)　117-121　2017/12
Publisher: (公財)福田記念医療技術振興財団
先天性心不全に対する新規Fontan clipの試験のための模擬肺循環システム(Mock pulmonary circulatory system for the examination of a new Fontan clip for congenial heart failure)

軽部雅人, 白石泰之, 山田昭博, 坪子侑佑, 中畑碧, 山家智之

人工臓器　46　(2)　S-176　2017/08
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
食物運搬機能を有する人工食道ステント開発のための非線形粘弾性モデルを用いた生体力学的特性解析

平恭紀, 白石泰之, 井上雄介, 山田昭博, 坪子侑佑, 池田純平, 荒川友哉, 弓場充, 馮忠剛, 山家智之

人工臓器　46　(1)　34-34　2017/06
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
Fontan循環クリップ開発のための設計構成要素の基礎検討

池田純平, 白石泰之, 坪子侑佑, 平恭紀, 山田昭博, 井上雄介, 山岸正明, 山家智之

人工臓器　46　(1)　35-35　2017/06
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
誤嚥性肺炎を予防する、パンとお米の食品科学に関する嚥下蠕動機能解析装置による研究

山家智之, 白石泰之, 井上雄介, 山田昭博

報告書 / エリザベス・アーノルド富士財団 [編]　124-128　2017
Publisher: 名古屋 : エリザベス・アーノルド富士財団
Effect of Total Artificial Heart for Microcirculation

Yusuke Inoue, Yasuyuki Shiraishi, Akihiro Yamada, Yusuke Tsuboko, Yasunori Taira, Tomoya Arakawa, Mitsuru Yuba, Masato Karube, Tatsuya Genda, Yusuke Abe, Takashi Isoyama, Itsuro Saito, Tomoyuki Yambe

Tohoku Forum for Creativity, Thematic Program 2017 Aging Science: from Molecules to Society　2　(3)　34　2017
Fontan circulation assist system in animal models

Akihiro Yamada, Yasuyuki Shiraishi, Jumpei Ikeda, Yusuke Tsuboko, Yasunori Taira, Yusuke Inoue, Masaaki Yamagishi, Dai Homma, Tomoyuki Yambe

4th Biomedical Sciences & 3rd Biomedical Engineering Symposium　3　(1)　9-10　2017
Preclinical approach for improving the shape design of paediatric pulmonary valved conduit

Yusuke Tsuboko, Yasuyuki Shiraishi, Akihiro Yamada, Yasunori Taira, Yusuke Inoue, Tomoya Arakawa, Mitsuru Yuba, Itsu Sen, Tomoyuki Yambe

4th Biomedical Sciences & 3rd Biomedical Engineering Symposium　3　(1)　11-12　2017
Development of artificial esophagus with an active food-propelling function

Yasunori Taira, Yasuyuki Shiraishi, Yusuke Inoue, Akihiro Yamada, Yusuke Tsuboko, Jumpei Ikeda, Tomoya Arakawa, Mitsuru Yuba, Tomoyuki Yambe

4th Biomedical Sciences & 3rd Biomedical Engineering Symposium　3　(1)　15-16　2017
Evaluation of adhesive reaction for percutaneous ports of implantable artificial organs

Mitsuru Yuba, Yasuyuki Shiraishi, Yusuke Inoue, Akihiro Yamada, Yusuke Tsuboko, Yasunori Taira, Jumpei Ikeda, Tomoya Arakawa, Makoto Ohta, Tomoyuki Yambe

4th Biomedical Sciences & 3rd Biomedical Engineering Symposium　3　(1)　19-20　2017
Design of a mock pulmonary circulation ssystem using lung specimen for evaluation of Fontan regulation clip

Masato Karube, Yasuyuki Shiraishi, Akihiro Yamada, Yusuke Inoue, Yasunori Taira, Aoi Nakahata, Tomoya Arakawa, Mitsuru Yuba, Tatsuya Genda, Masaaki Yamagishi, Tomoyuki Yambe

5th Biomedical Sciences & 4rd Biomedical Engineering Symposium　4　(1)　15-17　2017
Fundamental Study of Cooling System for Pulmonary Circulation Assist Device by Using Heat-Pipe

Yamada Akihiro, Tomoyuki Yambe, Okajima Jyunnosuke, Inoue Yusuke, Taira Yasunori, Ikeda Jyunpei, Yuba Mitsuru, Shiraishi Yasuyuki, Tsuboko Yusuke, Arakawa Tomoya

Trans. jpn. Soc. Med. Bio. Eng　55　(3)　235-235　2017
Publisher: Japanese Society for Medical and Biological Engineering
ISSN： 1347-443X

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We have been developed a pulmonary circulatory assist device for pediatric patients to promote hemodynamics of Fontan circulation. In this study, in order to develop the cooling system for a pulmonary circulatory assist device by heat pipes, we examined heat transfer response of the device, and we also designed basically heat transfer system by using heat pipes. In the animal experimental model, hot spot of during device contraction was around 45 degree Celsius in the rigid support sheath area. Whereas, there were no thermal elevation in extra cardiac conduit. From the temperature difference between the maximum device temperature and the blood temperature, we considered to be selecting the sealed gas and the filling pressure for heat pipe design. In the future prospects, we are due to develop prototype cooling system by waste heat to the blood vessel with heat pipe.
医療機器とEMC 埋め込み型医療機器開発に向けた電磁波適合性EMC問題

山家智之, 白石泰之, 井上雄介, 山田昭博

EMC : electro magnetic compatibility : solution technology : 電磁環境工学情報　29　(9)　70-84　2017/01
Publisher: [科学情報出版]
ISSN： 0916-2275
Improvement of the implantable renal nerve cooling device and examine the effect of cooling for nerve activity

Yuba Mitsuru, Nakagata Hiroshi, Shiraishi Yasuyuki, Inoue Yusuke, Yamada Akihiro, Tsuboko Yusuke, Yambe Tomoyuki

Transactions of Japanese Society for Medical and Biological Engineering　55　(3)　236-236　2017
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.55Annual.236 　

ISSN： 1347-443X

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The purpose of this study was to improve an implantable renal nerve cooling device which was capable of regulating the surface temperature of the renal nerve in hypertensive patients. We used a Peltier elements and performed a component design combined with a heat pipe for the implantable device as a proof of concept. The implantable device was composed two components: a) a Peltier element having 3.94 mm thickness with a rectangular cooling plate of 3.2 mm x 3.2 mm, b) a heat pipe having 6 mm diameter with 250 mm length, which was to be mechanically and thermally connected to the radiation surface of the Peltier element. We examined the surface cooling effects by a thermal camera against the several power supply conditions for the Peltier element. As a result, the cooling surface showed the controllable temperature by the electric power supply with the heat-pipe unit without any radiation fluids.
Development of Valve Test System for Evaluating the Pulmonary Trileaflet Motion

Tsuboko Yusuke, Shiraishi Yasuyuki, Yambe Tomoyuki

Transactions of Japanese Society for Medical and Biological Engineering　55　(3)　233-233　2017
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.55Annual.233 　

ISSN： 1347-443X

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An expanded polytetrafluoroethylene (ePTFE) pulmonary conduit valve is commonly used for the pulmonary valve reconstruction in patients with congenital heart failure. The special features of the valve are fan-shaped leaflets and the bulging sinus which is representing the Valsalva shape. The purpose of this study was to compare valvular motion in the newly designed pulmonary valve tester.To investigate valvular function under the low-pressure pulmonary hemodynamic condition, we used two different types of ePTFE leaflets and examined their characteristics by using a high-speed camera. Each 0.1 mm-thick leaflet with different cusp depth was installed in the conduit valve holder. The holder was connected to a linear actuator. We compared the relationships between leaflet motion and annular displacement.We could achieve the comparison of leaflet motion with different cusp, and it was suggested that the cusp depth might be an important parameter to optimize the coaptation zone in ePTFE pulmonary valves.
Analysis of swallowing motion by using non-contact 3-D skin deglutition measurement

Taira Yasunori, Shiraishi Yasuyuki, Inoue Yusuke, Yamada Akihiro, Tsuboko Yusuke, Arakawa Tomoya, Yuba Mitsuru

Transactions of Japanese Society for Medical and Biological Engineering　55　(5)　481-481　2017
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.55Annual.481 　

ISSN： 1347-443X

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Evaluation of swallowing motion is necessary for preventing aspiration pneumonia. MRI and sound analyses are recent deglutition diagnoses, however, these are inherently susceptible to noise. We focused on the detection of skin motion around pharyngeal portion, and examined the feasibility of information measured by a depth camera. Firstly, we measured the pharyngeal portion in healthy subjects during the process of drinking water or saline. Secondly, we measured the pharyngeal skin during eating process of a piece of bread pasted with oil or with high viscosity gelatin. Results were as follows: a) we obtained the prospective self-gating of swallowing using depth information, b) the measurement is available for frequency analysis of the gating, and c) the deglutition was associated with the taste with respect to the sensory inspection. Consequently, periodical measurements by the 3-D depth camera might be useful for the selection of profiles corresponding to food intake including individual preferences.
高齢者の嚥下・蠕動機能を非侵襲的に定量診断する解析装置の世界初の発明

山家智之, 白石泰之, 井上雄介, 山田昭博, 坪子侑佑

研究結果報告書集 : 交通安全等・高齢者福祉　23　125-129　2017
Publisher: 三井住友海上福祉財団
Hybrid Material for Helical Flow Ventricular Assist Device

Inoue Yusuke, Yamada Akihiro, Yambe Tomoyuki, Imachi Kou, Abe Yusuke, Kawase Yukino, Tashiro Ayaka, Saito Itsuro, Isoyama Takashi, Ishii Kohei, Hara Shintaro, Yurimoto Terumi, Shiraishi Yasuyuki

Transactions of Japanese Society for Medical and Biological Engineering　55　(3)　169-169　2017
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.55Annual.169 　

ISSN： 1347-443X

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An agenda of the ventricular assist devices is the clot formation, to cause cerebral infarction. The clot formed at the boundary between artificial materials and the living body. We were tried to develop new medical material by regenerating biotissue into the artificial material. In this report, we develop new inflow cannula use with hybrid material, and observed concrescence about heart and hybrid material. The scaffold was implanted under the skin and the biotissues ware regenerated into the scaffold. The hybrid cannula was made with this hybrid material, and evaluate it use with helical flow ventricular assist device by animal experiment. After 3 month, the cannula was fused with cardiac muscle smoothly. Any clot was observed on the surface of the hybrid material and gap between heart and the material. Endocapillary cell was observed surface of the material. These results show the usefulness of the medical material.
医工学と統合医療非臨床試験および前臨床試験手法を用いた心臓血管系診断に対する科学的アプローチ

井上雄介, 白石泰之, 山田昭博, 坪子侑佑, 平恭紀, 池田純平, 荒川友哉, 弓場充, 山家智之

日本統合医療学会誌　9　(3)　304-304　2016/12
Publisher: (一社)日本統合医療学会
医工学と統合医療脈波診断に医工学的根拠を付与する定量的評価手法の開発

山田昭博, 坪子侑佑, 井上雄介, 平恭紀, 白石泰之, 関隆志, 山家智之

日本統合医療学会誌　9　(3)　305-305　2016/12
Publisher: (一社)日本統合医療学会
医工学と統合医療動脈系末梢部の医工学的モデリングによる血圧血流応答

坪子侑佑, 白石泰之, 山家智之

日本統合医療学会誌　9　(3)　305-305　2016/12
Publisher: (一社)日本統合医療学会
医工学と統合医療食感特性評価のための嚥下挙動解析

平恭紀, 白石泰之, 井上雄介, 山田昭博, 坪子侑佑, 池田純平, 荒川友哉, 弓場充, 山家智之

日本統合医療学会誌　9　(3)　306-306　2016/12
Publisher: (一社)日本統合医療学会
生体内組織の局所温度調節による血圧制御の医工学的基礎検討

弓場充, 中潟寛, 白石泰之, 山田昭博, 井上雄介, 坪子侑佑, 平恭紀, 池田純平, 荒川友哉, 山家智之

日本統合医療学会誌　9　(3)　382-382　2016/12
Publisher: (一社)日本統合医療学会
東洋医学における脈診計測評価のための模擬循環回路の開発

齋藤大, 小林由佳, 渡邉健太郎, 坪子侑佑, 白石泰之, 荒川友哉, 山田昭博, 井上雄介, 平恭紀, 池田純平, 弓場充, 山家智之

日本統合医療学会誌　9　(3)　383-383　2016/12
Publisher: (一社)日本統合医療学会
左心循環補助時における心房細動が脈診計測へ及ぼす影響の基礎検討

小林由佳, 齋藤大, 渡邉健太郎, 白石泰之, 坪子侑佑, 弓場充, 山田昭博, 井上雄介, 平恭紀, 池田純平, 荒川友哉, 山家智之

日本統合医療学会誌　9　(3)　383-383　2016/12
Publisher: (一社)日本統合医療学会
補助人工心臓のポンプ性能差異による末梢脈波変化についての考察

渡邉健太郎, 齋藤大, 小林由佳, 白石泰之, 坪子侑佑, 山田昭博, 井上雄介, 平恭紀, 池田純平, 荒川友哉, 弓場充, 山家智之

日本統合医療学会誌　9　(3)　384-384　2016/12
Publisher: (一社)日本統合医療学会
完全埋め込み型高血圧治療装置

山家智之, 白石泰之, 鈴木拓志, 井上雄介, 山田昭博, 坪子侑佑

循環制御(Web)　37　(3)　185-189　2016/12
Publisher: 日本循環制御医学会
DOI： 10.11312/ccm.37.185 　

ISSN： 0389-1844
メラ遠心ポンプ血栓検出光センサの開発と大型動物実験における血栓検出性能評価

迫田大輔, 藤原立樹, 大内克洋, 白石泰之, 井上雄介, 三浦英和, 山田昭博, 桑名克之, 山崎浩行, 山家智之, 荒井裕国, 丸山修

人工臓器(日本人工臓器学会)　45　(2)　S.103　2016/10/31

ISSN： 0300-0818
ハイブリッド材料を用いた補助人工心臓用脱血管の生体適合性

井上雄介, 井上雄介, 田代彩夏, 川瀬由季乃, 斎藤逸郎, 磯山隆, 石井耕平, 圦本晃海, 原伸太郎, 岸亜由美, 白石泰之, 山田昭博, 三浦英和, 阿部裕輔, 山家智之

人工臓器(日本人工臓器学会)　45　(2)　S.104-104　2016/10/31
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818
電力制御によるFontan循環補助装置のための収縮制御モニタリングシステムの構築

山田昭博, 三浦英和, 白石泰之, 坪子侑佑, 平恭紀, 池田純平, 本間大, 山家智之

人工臓器　45　(2)　S-92　2016/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
小児用ePTFE製肺動脈弁付導管の形状改良のための静圧負荷逆流特性計測

坪子侑佑, 白石泰之, 山田昭博, 平恭紀, 池田純平, 山岸正明, 山家智之

人工臓器　45　(2)　S-150　2016/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
ステントグラフト内挿術における血流変動時の後負荷評価のための循環シミュレーションによる基礎検討

荒川友哉, 白石泰之, 坪子侑佑, 山田昭博, 井上雄介, 佐々木一益, 平恭紀, 池田純平, 高野智弘, 高野真澄, 横山斉, 山家智之

人工臓器　45　(2)　S-151　2016/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
Fontan循環クリップ開発のための設計構成要素の基礎検討

池田純平, 白石泰之, 坪子侑佑, 平恭紀, 山田昭博, 井上雄介, 山岸正明, 山家智之, 本間大

人工臓器　45　(2)　S-151　2016/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
皮膚組織を貫通する人工物の癒着強度評価試験のための基礎検討

弓場充, 坪子侑佑, 白石泰之, 井上雄介, 平恭紀, 太田信, 山家智之

人工臓器　45　(2)　S-159　2016/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
食物運搬機能を有する人工食道ステント開発のための非線形粘弾性モデルを用いた生体力学的特性解析

平恭紀, 白石泰之, 井上雄介, 山田昭博, 坪子侑佑, 池田純平, 荒川友哉, 弓場充, 山家智之

人工臓器　45　(2)　S-161　2016/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
医療用ハイブリッド材料の滅菌に関する研究

井上雄介, 田代彩夏, 磯山隆, 斎藤逸郎, 阿部裕輔, 白石泰之, 山田昭博, 坪子侑佑, 原伸太郎, 圦本晃海, 三浦英和, 山家智之

LIFE講演概要集(CD-ROM)　2016　ROMBUNNO.1P2‐F04-069　2016/09/04
Publisher: (一社)ライフサポート学会
医療用ハイブリッド材料の滅菌に関する研究

井上雄介, 田代彩夏, 磯山隆, 斎藤逸郎, 阿部裕輔, 白石泰之, 山田昭博, 坪子侑佑, 原伸太郎, 圦本晃海, 三浦英和, 山家智之

生活生命支援医療福祉工学系学会連合大会講演要旨集　2016　067-069　2016/09
Publisher: (一社)ライフサポート学会
血管ステント治療における心機能の後負荷評価モデル構築の試み

荒川友哉, 白石泰之, 坪子侑佑, 山田昭博, 井上雄介, 平恭紀, 佐々木一益, 渡辺祥太, 池田純平, 弓場充, 山家智之, 高野智弘, 高野真澄, 横山斉

生活生命支援医療福祉工学系学会連合大会講演要旨集　2016　070-072　2016/09
Publisher: (一社)ライフサポート学会
高精度な血液循環模擬による右心循環補助デバイスの医工学評価

坪子侑佑, 白石泰之, 山田昭博, 平恭紀, 井上雄介, 佐々木一益, 渡辺祥太, 池田純平, 荒川友哉, 弓場充, 山家智之

生活生命支援医療福祉工学系学会連合大会講演要旨集　2016　470-471　2016/09
Publisher: (一社)ライフサポート学会
高血圧治療を目的とした埋込型腎神経冷却デバイスの改良

弓場充, 白石泰之, 中潟寛, 山田昭博, 坪子侑佑, 井上雄介, 佐々木一益, 平恭紀, 渡辺祥太, 池田純平, 荒川友哉, 山家智之

生活生命支援医療福祉工学系学会連合大会講演要旨集　2016　745-747　2016/09
Publisher: (一社)ライフサポート学会
心臓と人工をシームレスに接続可能なハイブリッド脱血カニュの開発

井上雄介, 白石泰之, 三浦英和, 川瀬由季, 田代彩夏, 前野映里奈, 山家智之, 斎藤逸郎, 磯山隆, 小野俊哉, 原伸太郎, 圦本晃海, 村上遥, 李欣陽, 阿部裕輔, 石井耕平

北海道外科雑誌　61　(1)　124-124　2016/06/20
Publisher: 北海道外科学会
ISSN： 0288-7509
小児用ePTFE製肺動脈弁の弁葉およびbulging sinusが弁機能へ及ぼす影響の基礎検討

坪子侑佑, 武良盛太郎, 白石泰之, 山田昭博, 山岸正明, 山家智之

人工臓器　45　(1)　40-40　2016/06
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
ePTFE製肺動脈弁の弁挙動解析の基礎検討

武良盛太郎, 坪子侑佑, 白石泰之, 三浦英和, 山岸正明, 山家智之

人工臓器　45　(1)　41-41　2016/06
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
低レイノルズ数領域における血液環流フローチャンバーシステムの開発

安西眸, 白石泰之, 山家智之, 太田信

日本バイオレオロジー学会誌(Web)　30　(2)　2016

ISSN： 2186-5663
Biomimetic artificial tongue for the mastication and the peristalsis

Tomoyuki Yambe, Yasuyuki Shiraishi, Yusuke Inoue, Akihiro Yamada

The International Journal of Artificial Organs　39　(7)　374　2016
Thermodynamic Effect on Fontan Circulation Assist Device

Akihiro Yamada, Yasuyuki Shiraishi, Hidekazu Miura, Yusuke Tsuboko, Yasunori Taira, Yusuke Inoue, Homma Dai, Masaaki Yamagishi, Tomoyuki Yambe

Thirteenth International Conference on Flow Dynamics Proceedings　2016　(-)　344-345　2016
Implantable Renal Nerve Heat Control Device for Pressure Regulation in Hypertension

Yasuyuki Shiraishi, Hiroshi Nakagata, Mitsuru Yuba, Takuji Suzuki, Yusuke Tsuboko, Akihiro Yamada, Yusuke Inoue, Kazumasu Sasaki, Hiroo Kumagai, Tomoyuki Yambe

Thirteenth International Conference on Flow Dynamics Proceedings　2016　(-)　346-347　2016
Flexible Multi-point Temperature Sensors for Body Temperature

Yusuke Inoue, Yasuyuki Shiraishi, Akihiro Yamada, Tomoyuki Yambe

Thirteenth International Conference on Flow Dynamics Proceedings　2016　(-)　348-349　2016
Development of hybrid material for inflow cannula

Inoue Yusuke, Tashiro Ayaka, Abe Yusuke, Isoyama Takashi, Saito Itsuro, Shiraishi Yasuyuki, Miura Hidekazu, Yamada Akihiro, Yambe Tomoyuki

Trans. jpn. Soc. Med. Bio. Eng　54　(28)　S362-S362　2016
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.54Annual.S362 　

ISSN： 1347-443X

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補助人工心臓において、脱血カニューレの心筋挿入部位周囲に血栓が形成されることが問題となっている。血栓形成の主因はカニューレの生体適合性であると考えられており、材料表面に形成される血栓と、心筋とカニューレの間隙に生じる凝血塊がクリアすべき課題である。この問題を解決すべく、新たに開発したハイブリッド材料を用いて脱血カニューレの作製を試みた。ハイブリッド材料は、人工材料と生体由来材料とを組み合わせた材料のことで、組織新生の足場となる人工材料を生体の皮下に埋め込み、生体組織と人工材料とを一体化させることにより得る。作製した材料に脱細胞化処理を行うことで細胞外マトリックスのみを残し、細胞成分を除去することで同種移植が可能な材料となる。このように作製した材料は、人工材料の強度と、細胞外マトリックスによる高い生体適合性を持つ材料となると考えた。開発した材料を用いて補助人工心臓用脱血カニューレを作製し, VADと共にヤギに埋め込み、慢性実験を行った。実験期間中は、抗凝固療法、免疫抑制療法を行わなかった。実験終了後、カニューレと心筋はきれいに癒合しており、カニューレ内腔および外側に、問題とされている血栓は認められず、良好な結果を得た。
Development of a novel bearing and driving system for the right ventricle pump of total artificial heart

Miura Hidekazu, Hagio Yuuki, Inoue Yusuke, Yamada Akihiro, Shiraishi Yasuyuki, Yambe Tomoyuki

Trans. jpn. Soc. Med. Bio. Eng　54　(26)　S51-S51　2016
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.54Annual.S51 　

ISSN： 1347-443X

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In this study, a bearing and motor system of the right heart pump was designed for a continuous flow total artificial heart. We evaluated the performance of the motor in the winch examination. Also, we examined the influence of the gap between the stator and the rotor under the constant drive voltage condition. The gap was changed from 1.0 mm to 2.5 mm. The motor with larger gap has higher rotational speed coefficient, and lower torque coefficient. On the other hand, the motor with smaller gap has lower rotational speed coefficient and higher torque coefficient. In shaft output, we could not find significant difference with the operational range. The motor with larger gap has lower efficiency when the torque is larger than 5.0 mNm. The motor with larger gap has higher efficiency when the torque is smaller than 5.0 mNm.
Design and evaluation of a newly developed Fontan clip

Ikeda Jumpei, Yambe Tomoyuki, Shiraishi Yasuyuki, Yamada Akihiro, Tsuboko Yusuke, Taira Yasunori, Suzuki Takuji, Inoue Yusuke, Homma Dai, Yamagishi Masaaki

Transactions of Japanese Society for Medical and Biological Engineering　54　(26)　S16-S16　2016
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.54Annual.S16 　

ISSN： 1347-443X
Hemodynamic examination for shape optimization of ePTFE valved conduit with bulging sinuses

Tsuboko Yusuke, Shiraishi Yasuyuki, Miura Hidekazu, Inoue Yusuke, Yamada Akihiro, Taira Yasunori, Ikeda Jumpei, Yamagishi Masaaki, Yambe Tomoyuki

Transactions of Japanese Society for Medical and Biological Engineering　54　(26)　S54-S54　2016
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.54Annual.S54 　

ISSN： 1347-443X
Newly development of implantable Fontan circulation assist device

Yamada Akihiro, Yambe Tomoyuki, Shiraishi Yasuyuki, Miura Hidekazu, Taira Yasunori, Tsuboko Yusuke, Ikeda Jyunpei, Inoue Yusuke, Yamagishi Masaaki, Homma Dai

Transactions of Japanese Society for Medical and Biological Engineering　54　(26)　S52-S52　2016
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.54Annual.S52 　

ISSN： 1347-443X
Biomechanical characteristic analysis of natural esophageal using a non-liner viscoeolastic model

Taira Yasunori, Mura Seitaro, Ikeda Jumpei, Homma Dai, Yambe Tomoyuki, Shiraishi Yasuyuki, Miura Hidekazu, Inoue Yusuke, Sasaki Kazumasu, Yamada Akihiro, Tsuboko Yusuke, Suzuki Takuji, Hagio Yuki

Transactions of Japanese Society for Medical and Biological Engineering　54　(28)　S347-S347　2016
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.54Annual.S347 　

ISSN： 1347-443X
遠心血液ポンプ内非侵襲血栓形成光モニタの実用化

迫田大輔, 藤原立樹, 大内克洋, 白石泰之, 井上雄介, 三浦英和, 山田昭博, 桑名克之, 山崎浩行, 山家智之, 荒井裕国, 丸山修

日本栓子検出と治療学会プログラム・抄録集　19th　56　2016
Estimation of beat timing and cardiac function during circulatory support using rotary blood pump parameters

Hataya Genta, Tanaka Akira, Yoshizawa Makoto, Siraishi Yasuyuki, Miura Hidekazu, Yambe Tomoyuki

Transactions of Japanese Society for Medical and Biological Engineering　54　(27)　S185-S185　2016
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.54Annual.S185 　

ISSN： 1347-443X

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So far, we have proposed the control algorithm to synchronize output of ventricular assist device to native heart cycle without external sensors such as ECG. In the method, heartbeat component in pump rotational speed was regarded as disturbance to controlled rotational speed. Thus the heartbeat signal was calculated as estimation error of rotational speed. Moreover this signal seems to have also information of native heart function. Therefore, the aim of this study is to attempt to estimate cardiac function from the estimated heartbeat signal.The instantaneous pump speed was estimated by an ARX model which inputs were reference speed and current consumption. The parameters of the model were calculated by using recursive identification algorithm.In results, some features of the estimated heartbeat signal have a close relationship with circulatory parameters. Therefore, it was indicated that the proposed method may be able to estimate not only cardiac cycle but function.
生体適合性の高い補助人工心臓用ハイブリッド脱血カニューレの開発

井上雄介, 井上雄介, 川瀬由季乃, 田代彩夏, 磯山隆, 斎藤逸郎, 小野俊哉, 原伸太郎, 圦本晃海, 李欣陽, 村上遥, 前野映里奈, 三浦英和, 白石泰之, 山家智之, 井街宏, 阿部裕輔

人工臓器(日本人工臓器学会)　44　(2)　S.84-84　2015/10/30
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818
右心バイパス血流路を有する動物実験モデルによる小児用肺循環補助装置の血行動態評価

山田昭博, 白石泰之, 三浦英和, 坪子侑佑, 平恭紀, 井上雄介, 山岸正明, 本間大, 山家智之

人工臓器　44　(2)　S-99　2015/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
CCDを用いた埋め込み型小型肺循環血流観察デバイス開発のための基礎検討

渡辺祥太, 白石泰之, 三浦英和, 井上雄介, 山田昭博, 坪子侑佑, 平恭紀, 山家智之

人工臓器　44　(2)　S-172　2015/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
右心循環用に用いる人工心臓用モータの性能評価

萩尾勇樹, 三浦英和, 白石泰之, 片平晋太郎, 佐々木一益, 山田昭博, 坪子侑佑, 平恭紀, 山家智之

人工臓器　44　(2)　S-173　2015/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
小児用ePTFE製肺動脈弁の弁葉およびbulging sinusが弁機能へ及ぼす影響の基礎検討

坪子侑佑, 白石泰之, 武良盛太郎, 山田昭博, 山岸正明, 山家智之

人工臓器　44　(2)　S-174　2015/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
ePTFE製肺動脈弁の弁挙動解析の基礎検討

武良盛太郎, 白石泰之, 坪子侑佑, 三浦英和, 山岸正明, 山家智之

人工臓器　44　(2)　S-175　2015/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
本態性高血圧治療を目的とした腎神経活動制御のための埋め込み型腎神経冷却装置の基礎検討

鈴木拓志, 白石泰之, 三浦英和, 山田昭博, 坪子侑佑, 平恭紀, 井上雄介, 山家智之

人工臓器　44　(2)　S-185　2015/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
食物運搬機能を有する人工食道のための嚥下検知システムの設計開発

平恭紀, 白石泰之, 三浦英和, 井上雄介, 佐々木一益, 山田昭博, 坪子侑佑, 鈴木拓志, 萩尾勇樹, 武良盛太郎, 渡辺祥太, 本間大, 山家智之

人工臓器　44　(2)　S-185　2015/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
右心模擬循環シミュレーションモデルによる小型右心用人工心筋の改良

白石泰之, 片平晋太郎, 山田昭博, 鈴木拓志, 井上雄介, 三浦英和, 秋山正年, 佐々木一益, 齋木佳克, 山家智之, 本間大

人工臓器　44　(2)　S-84　2015/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818
遠心型血液ポンプを用いた体外設置型補助人工心臓のコネクタ部の流れ解析

庄内千紘, 片平晋太郎, 武良盛太郎, 井上雄介, 菊地昭二, 白石泰之, 齋木佳克, 山家智之

人工臓器　44　(2)　S-176　2015/10
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818
PS1-4 Evaluation of frozen vascular grafts by using MRE : how to keep the characteristics of bioprostheses?(PS1: Poster Short Presentation I,Poster Session)

Watanabe Shota, Taira Yasunori, Suzuki Hayato, Miura Hidekazu, Inoue Yusuke, Sasaki Kazumasu, Shiraishi Yasuyuki, Yambe Tomoyuki, Tadano Shigeru

Proceedings of the ... Asian Pacific Conference on Biomechanics : emerging science and technology in biomechanics　2015　(8)　225-225　2015/09/16
Publisher: The Japan Society of Mechanical Engineers
ハイブリッド材料の抗血栓性と生体癒合に関する研究

井上雄介, 川瀬由季乃, 田代彩夏, 斎藤逸郎, 磯山隆, 小野俊哉, 原伸太郎, 圦本晃海, LI Xin Yang, 前野映里奈, 石井耕平, 白石泰之, 三浦英和, 山家智之, 阿部裕輔

生活生命支援医療福祉工学系学会連合大会講演論文集(CD-ROM)　2015　ROMBUNNO.2D1-01-58　2015/09/07
Publisher: (一社)ライフサポート学会
環境温度変化における遠心型補助人工心臓駆動時の心臓血管系の応答解析

武良盛太郎, 白石泰之, 山田昭博, 三浦英和, 坪子侑佑, 佐野恭介, 平恭紀, 鈴木拓志, 萩尾勇樹, 渡辺祥太, 山家智之

人工臓器　44　(1)　29-29　2015/06
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
Artificial Sphincter

YAMBE Tomoyuki, SHIRAISHI Yasuyuki, MIURA Hidekazu

The Journal of the Institute of Electronics, Information, and Communication Engineers　98　(4)　290-294　2015/04
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5693
Effect of Japanese traditional food material, Miso on the baroreflex sensitivity of the heart and artery during the audiovisual immersion

(36)　84-90　2015/03
Publisher: 中央味噌研究所
ISSN： 0289-8942
Mechanical Circulatory Assistance and a Non-invasive Perfusion Measurements

Yasuyuki Shiraishi, Kazumasu Sasaki, Yoshikazu Kaneko, Tomoya Kitano, Shota Watanabe, Yusuke Inoue, Yusuke Tsuboko, Akihiro Yamada, Hidekazu Miura, Akira Tanaka, Makoto Yoshizawa, Shintaro Katahira, Yoshikatsu Saiki, Dai Homma, Tomoyuki Yambe

Biomedical Science and Technology　1　(1)　20-22　2015
Static Characteristics of the Interaction between the Expanded Polytetrafluoroethylene Valve Conduit Shape and Leaflet

Yusuke Tsuboko, Takuji Suzuki, Seitaro Mura, Yasuyuki Shiraishi, Akihiro Yamada, Hidekazu Miura, Yusuke Inoue, Kazumasu Sasaki, Yasunori Taira, Junpei Ikeda, Masaaki Yamagishi, Yi Qian, Tomoyuki Yambe

Biomedical Science and Technology　1　(1)　20-22　2015
Compliance Change in Natural Esophagus for the Sophisticated Design of Artificial Esophagus

Yasunori Taira, Yasuyuki Shiraishi, Hidekazu Miura, Yusuke Inoue, Akihiro Yamada, Yusuke Tsuboko, Takuji Suzuki, Yuki Hagio, Seitaro Mura, Shota Watanabe, Jumpei Ikeda, Dai Homma, Tomoyuki Yambe

Biomedical Science and Technology　1　(1)　23-26　2015
Preliminary Approach for Controlling Sympathetic Nervous Activity by Cooling Rrenal Nerves in Animal Experiments

Hiroshi Nakagata, Takuji Suzuki, Yasuyuki Shiraishi, Hidekazu Miura, Yusuke Inoue, Akihiro Yamada, Yusuke Tsuboko, Yasunori Taira, Hiroo Kumagai, Tomoyuki Yambe

Biomedical Science and Technology　1　(1)　27-29　2015
Development of a New Implantable Nerve Cooling System for Hypertension: Heat Transfer Characteristics in Animal Experiments

Takuji Suzuki, Yasuyuki Shiraishi, Hiroshi Nakagata, Hidekazu Miura, Yusuke Inoue, Akihiro Yamada, Yusuke Tsuboko, Yasunori Taira, Hiroo Kumagai, Tomoyuki Yambe

Biomedical Science and Technology　1　(1)　30-33　2015
Design of the Centrifugal Artificial Right Heart for an Implantable Total Artificial Heart

Yuki Hagio, Hidekazu Miura, Yasuyuki Shiraishi, Shintaro Katahira, Yusuke Inoue, Kazumasu Sasaki, Takuya Shiga, Akihiro Yamada, Yusuke Tsuboko, Yasunori Taira, Tomoyuki Yambe

Biomedical Science and Technology　1　(1)　34-35　2015
Comparison of the Trileaflet Valve Motion in the Newly Designed Pediatric Pulmonary Valve Tester

Seitaro Mura, Yasuyuki Shiraishi, Yusuke Tsuboko, Akihiro Yamada, Yusuke Inoue, Kazumasu Sasaki, Masaaki Yamagishi, Yi Qian, Tomoyuki Yambe

Biomedical Science and Technology　1　(1)　36-41　2015
Conceptual Design of a New Total Cavopulmonary Connection Assistance Device for Fontan Circulation

Junpei Ikeda, Yasuyuki Shiraishi, Yusuke Tsuboko, Akihiro Yamada, Yusuke Inoue, Yasunori Taira, Takuji Suzuki, Seitaro Mura, Dai Homma, Masaaki Yamagishi, Tomoyuki Yambe

Biomedical Science and Technology　1　(1)　42-45　2015
in vitro Modelling of Aortic Aneurysm for Stent Examination

Shoto Ueda, Seitaro Mura, Yuki Shioji, Akihito Kawachi, Takaya Tazawa, Yuki Okada, Yasuyuki Shiraishi, Yasunori Taira, Takuji Suzuki, Hidekazu Miura, Yusuke Inoue, Hiroshi Nakagata, Kazumasu Sasaki, Kazuhiko Hanzawa, Tomoyuki Yambe

Biomedical Science and Technology　1　(1)　46-47　2015
Wireless Energy Transmission Technology for Non Invasive Measurements and Infection Free Implantable Devices

Hidekazu Miura, Yusuke Inoue, Akihiro Yamada, Yusuke Tsuboko, Yasunori Taira, Kazumasu Sasaki, Yasuyuki Shiraishi, Tomoyuki Yambe

Non-invasive measurement in cardiovascular dynamics　1　(1)　12-15　2015
Novel direct charging method of internal battery for Transcutaneous Energy Transmission System

MIURA HIDEKAZU, YAMDA AKIHIRO, SHIRAISHI YASUYUKI, YAMBE TOMOYUKI

Trans. jpn. Soc. Med. Bio. Eng　53　(0)　S199_01-S199_01　2015
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.53.S199_01 　

ISSN： 1347-443X

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Development of internal rechargeable battery for totally implantable artificial organs is major problem for transcutaneous energy transmission systems (TETS). Also their charging systems have to be considered. Lithium ion batteries were charged in the constant current (CC), constant voltage (CV) method. A switching mode converter is used for this charge control. However devices are suffered from high frequency and ripple current and voltage. Their risks of failure are relatively high, also size and temperature rise are great concerns. In this study, we examined a new internal rechargeable battery charge system. In which the battery is directly connected to the output of the internal rectifying circuit of TETS, and the charging current is controlled by the external circuit.Our TETS has a series resonant property therefore, by changing driving frequency, the output can be controlled. The input current is sensed and controlled to be a constant current by changing frequency. When the frequency reaches the lower limit, the maximum output voltage is induced. Therefore the rechargeable battery is connected via an overvoltage protective circuit.
The evaluation of motor characteristics of the total artificial heart by the change in the rotor to stator gap

HAGIO YUUKI, MIURA HIDEKAZU, SHIRAISHI YASUYUKI, SHIGA TAKUYA, YAMADA AKIHIRO, TSUBOKO YUSUKE, SANO KYOSUKE, TAIRA YASUNORI, YAMBE TOMOYUKI

Transactions of Japanese Society for Medical and Biological Engineering　53　(0)　S198_02-S198_02　2015
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.53.S198_02 　

ISSN： 1347-443X

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In the development of total artificial heart (TAH), we must design left and right pumps separately to achieve a proper flow balance. In this study, we designed a motor of pump to maintain right heat circulation and prototyped. The Motor was designed by using Assumptive Magnetic Flux Path Method. We made equivalent circuit by this method, and evaluated synthetic reluctance, magnetic flux of gap for the purpose of inhibiting magnetic saturation. We adopted structure of DC brushless, four poles and 12 slots. We assumed the pump efficiency was 50%.We set maximum amount of cardiac output was 10L/min, maximum pressure was 20mmHg when rotation number was 3000rpm.In measurement, we examined the effect of gap difference, we changed the gap was 1.0 mm and 1.5 mm respectively. Result of measurement, torque and speed constants was 55 mNm/A and 180 rpm/V, 51 mNm/A and 198 rpm/V when the gap difference was 1.0 mm and 1.5 mm respectively. We confirmed the characteristics of the motor tend to high torque when the gap is narrow. On the other hand, it tends to high revolution when the gap is wide.
Preliminary study for the development of a sophisticated pulmonary vascular resistance model

TSUBOKO YUSUKE, WATANABE SYOTA, SHIRAISHI YASUYUKI, MIURA HIDEKAZU, YAMADA AKIHIRO, SUZUKI TAKUJI, TAIRA YASUNORI, YAMBE TOMOYUKI

Transactions of Japanese Society for Medical and Biological Engineering　53　(0)　S200_01-S200_01　2015
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.53.S200_01 　

ISSN： 1347-443X

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The authors have been developing a pulmonary mechanical simulator in order to establish a design parameters of a novel artificial cardiovascular devices. In pulmonary circulation, interactive pressure-flow changes are regulated by pulmonary impedance characteristics. We focused on the native impedance characteristics variation in the pulmonary circulation. To examine the effect of respiratory control on pulmonary resistance, we measured pulmonary arterial pressure and flow in adult goat under the different respiratory settings with open/closed-chest condition. Pulmonary input impedance in two respiratory conditions under the anesthetized open-chest positive pressure ventilation (PPV) and the awake spontaneous respiration (SR) were calculated. Longitudinal impedance at 0 Hz in SR showed lower than in PPV, and at high harmonic area in SR was bigger than in PPV. In order to examine the hemodynamic response for newly designed artificial internal organs, pulmonary impedance variation caused by respiratory control should be considered. For sophisticated pulmonary resistance model, reproducing the negative pressure condition in the thoracic cavity, and pulmonic vascular resistance regulation might be required.
Examination of pediatric pulmonary circulation assist device based on Fontan circulation animal experimental model

YAMADA AKIHIRO, Shiraisihi Yasuyuki, Miura Hidekazu, Tsuboko Yusuke, Taira Yasunori, Sano Kyosuke, Yamagishi Masaaki, Homma Dai, Yambe Tomoyuki

Transactions of Japanese Society for Medical and Biological Engineering　53　(0)　S201_01-S201_01　2015
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.53.S201_01 　

ISSN： 1347-443X

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Fontan procedure is the final palliative surgical operation in pediatric patients with congenital heart disease. After Fontan procedure, there is non-pulsatile flow in the pulmonary circulation. We have been developing the pulmonary circulation assist device for the Fontan circulation using shape memory alloy fibers. The device structure is mechanically contraction from the outside of the extracardiac conduit. For clinical application of the device, we have been also developing the animal experimental model for in vivo examination of the Fontan circulation assist device. In this study, we examined the hemodynamics change in the device driving the animal experimental model. The animal experimental model was constructed in four adult goats (45.8±15.6 kg). The right heart bypass of inferior vena cava to pulmonary artery was constructed by using extracardiac conduit, and the left ventricular assist device was connected to reduce of left ventricular load. The device could be mounted easily to the conduit in the thoracic cavity. The pulsatile flow could be generated in the pulmonary circulation by the device contraction. We performed the evaluation of the pediatric pulmonary circulatory assist device in the animal experimental model.
Development of behavior measurement apparatus for ePTFE pulmonary valve

MURA SEITARO, SIRAISHI YASUYUKI, Tuboko Yusuke, Miura Hidekazu, Yambe Tomoyuki

Transactions of Japanese Society for Medical and Biological Engineering　53　(0)　S202_01-S202_01　2015
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.53.S202_01 　

ISSN： 1347-443X

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Congenital heart disease as represented by Tetralogy of Fallot (TOF) and Transposition of great arteries may be dysfunction at right heart circulation.Surgical procedure for these cardiac arrest using pulmonary valve made from ePTFE is attracting attention. Clinical result in Japan, surgical procedure using pulmonary valve made from ePTFE is better than using biological valve in terms of thrombus formation and calcification. In order to design this valve, we need know behavior of valve cusp made from ePTFE. This valve is widely applied to clinical site and needed high-performance and high-durability. In this study, we discuss objective assessment for reduce right heart strain by improving pulmonary regurgitation base on high-precision analysis of valve cusp behavior. We manufacture reciprocating motion apparatus for analysis of valve cusp behavior under any flow condition and certain pressure load and studied mechanical characteristic of valve.
Design of a detachable swallowing sensor for the artificial esophagus

TAIRA YASINORI, Watanabe Syota, Homma Dai, Kamiya Kuraudo, Shiraishi Yasuyuki, Miura Hidekazu, Yamada Akihiro, Tsuboko Yusuke, Suzuki Takuji, Hagio Yuki, Mura Seitaro

Transactions of Japanese Society for Medical and Biological Engineering　53　(0)　S185_01-S185_01　2015
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.53.S185_01 　

ISSN： 1347-443X

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There have been demands for improving the level of activity of daily life for the patients with serious esophageal cancer. We have been developing an artificial esophagus by using Ni-Ti shape memory alloy fiber for those patients. The total installation of the device could replay the natural form of food delivery from the mouth to the stomach. In this study, we paused on the interaction control of the deglutition artificial esophagus motion by the natural trigger of the deglutition. Firstly, we made a synchronization system for swallowing required by the sensing of the throat skin acceleration. Then, we examined the sensing activity of swallowing motion detection. We performed an animal experiment to measure the surface motion caused by the deglutition using the accelerometry sensor attached to the goat throat. Secondly, we implemented an additional wireless formation in the sensing system in order to achieve the transcutaneous motion synchronization less invasively. As a result, the system developed in this study exhibited the capability of sensing by the accelerometry of swallowing motion for the sophisticated functional design for a totally implantable artificial esophagus.
Improvement of an implantable renal sympathetic cooling device

SUZUKI TAKUJI, YAMBE TOMOYUKI, SHIRAISHI YASUYUKI, MIURA HIDEKAZU, YAMADA AKIHIRO, TSUBOKO YUSUKE, SANO KYOSUKE, TAIRA YASUNORI

Transactions of Japanese Society for Medical and Biological Engineering　53　(0)　S267_03-S267_03　2015
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.53.S267_03 　

ISSN： 1347-443X

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Peripheral nerves transmission block is an important technique for neurophysiology and biomedical studies. For example, it is known that hypertension is contributed to by enhanced activity of the sympathetic nerve tension based on the generic preposition. Recently, development of renal sympathetic denervation (RSDN) enables us to inhibit renal sympathetic nerve activity (RSNA) by removing renal nerve as hypertensive therapy. The approach using RSDN shows that it is very much therapy, but its long-term safety and effectiveness is still under study. Up to now, we have been working in research and development of a technique that provides a quickly initiated and reversible nerve transmission block. In this study, we developed a prototype renal sympathetic cooling device that can block nerve transmission. This device can be inserted through a catheter and has a structure to be placed around renal nerve. It consists of a Peltier element that cooling area is 2.36 mm × 2.38 mm, and a heat sink at heat dissipation surface. For the purpose of its feasibility study, we evaluated the effectiveness of nerves cooling to block nerve transmission without producing nerve “onset response” firing in animal experiments.
Behavior pattern and the Autonomic function of the cardiovascular system in the subjects with functional food intake

山家智之, 吉澤誠, 白石泰之, 井上雄介, 山田昭博, 坪子侑佑

飯島藤十郎記念食品科学振興財団年報　31　272-279　2015
Publisher: 飯島藤十郎記念食品科学振興財団
ISSN： 2188-0662
ねじれ構造による能動的閉鎖を可能とする形状記憶合金線維を用いた新しい人工食道の開発研究

平恭紀, 神谷蔵人, 白石泰之, 三浦英和, 志賀卓弥, HASHEM Mohamed, 山田昭博, 坪子侑佑, 佐野恭介, 鈴木拓志, 萩尾勇樹, 武良盛太郎, 渡辺祥太, 本間大, 山家智之

人工臓器(日本人工臓器学会)　43　(2)　S.137-137　2014/09/22
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
遠心ポンプを用いた全置換型人工心臓の駆動部設計

萩尾勇樹, 三浦英和, 白石泰之, 志賀卓弥, 山田昭博, 坪子侑佑, HASHEM M・O, 佐野恭介, 平恭紀, 山家智之

人工臓器(日本人工臓器学会)　43　(2)　S.155-155　2014/09/22
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
遠心型補助人工心臓を用いた左心補助駆動下の、非接触肺循環血流計測の試み

渡辺祥太, 白石泰之, 佐野恭介, 廣橋義寛, 三浦英和, ハシム・モハメド・オムラン, 山田昭博, 坪子侑佑, 平恭紀, 山家智之

人工臓器　43　(2)　S-152　2014/09
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
補助循環下におけるハイスピードCCDカメラを用いた腎臓の末梢血管インピーダンス計測

佐野恭介, 北野智哉, 白石泰之, 三浦英和, ハシム・モハメド, 山田昭博, 坪子侑佑, 廣橋義寛, 平恭紀, 鈴木拓志, 萩尾勇樹, 武良盛太郎, 渡辺祥太, 田中明, 吉澤誠, 山家智之

人工臓器　43　(2)　S-170　2014/09
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
環境温度変化における遠心型補助人工心臓駆動時の心臓血管系の応答解析

武良盛太郎, 白石泰之, 山田昭博, 三浦英和, ハシム・モハメド, 坪子侑佑, 佐野恭介, 平恭紀, 鈴木拓志, 萩尾勇樹, 渡辺祥太, 山家智之

人工臓器　43　(2)　S-171　2014/09
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
形状記憶合金線維を用いた人工心筋アクチュエータのための絶縁コーティングに関する基礎研究

山田昭博, 白石泰之, 三浦英和, ハシム・モハメド, 平恭紀, 坪子侑佑, 佐野恭介, 本間大, 山家智之

人工臓器　43　(2)　S-171　2014/09
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
定常流型補助人工心臓の圧力流量特性条件が循環に与える影響

北野智哉, 佐野恭介, 廣橋義寛, 坪子侑佑, 山田昭博, 三浦英和, 白石泰之, 山家智之

人工臓器　43　(2)　S-198　2014/09
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
低圧系循環での人工弁に対するバルサルバ形状がもたらす意義 ex-vivo研究

松尾諭志, 坪子侑佑, 白石泰之, 高原真吾, 坂爪公, 松村宣寿, 細山勝寛, 正木直樹, 神田桂輔, 片平晋太郎, 鈴木智之, 伊藤校輝, 早津幸弘, 河津聡, 藤原英記, 安達理, 熊谷紀一郎, 川本俊輔, 山家智之, 齋木佳克

人工臓器　43　(2)　S-185　2014/09
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818
2C25 Nonclinical animal studies for medical devices research in Tohoku University

SHIRAISHI Yasuyuki, YAMBE TOMOYUKI, MIURA Hidekazu, AKIYAMA Masatoshi, SAIKI Yoshikatsu

2014　(26)　355-356　2014/01/10
Publisher: The Japan Society of Mechanical Engineers
2D45 Contactless measurement of peripheral perfusion by using a CCD camera

SANO Kyosuke, KITANO Tomoya, SHIRAISHI Yasuyuki, TANAKA Aakira, YOSHIZAWA Makoto, YAMBE Tomoyuki

2014　(26)　429-430　2014/01/10
Publisher: The Japan Society of Mechanical Engineers
2C45 Mechanical modeling approach for the development of peristaltic artificial esophagus

TAIRA Yasunori, KAMIYA Kurodo, SHIRAISHI Yasuyuki, HOMMA Dai, YAMBE Tomoyuki

2014　(26)　383-384　2014/01/10
Publisher: The Japan Society of Mechanical Engineers
Measurement of the pulmonary input impedance for development of a sophisticated pulmonary vascular resistance model

Tsuboko Yusuke, Shiraishi Yasuyuki, Yamada Akihiro, Shiga Takuya, Sano Kyosuke, Yambe Tomoyuki

Transactions of Japanese Society for Medical and Biological Engineering　52　(0)　O-315-O-316　2014
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.52.O-315 　

ISSN： 1347-443X

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The authors have been developing a pulmonary mechanical circulatory system in order to establish design parameters of newly designed artificial cardiovascular devices. In the quantitative examination of heart valves in pulmonary mock circulation, interactive changes in pressure and flow are regulated by pulmonary impedance characteristics. We focused on the native characteristics changes in impedance in the pulmonary circulation. To obtain the effect of respiratory control on pulmonary resistance, we measured pulmonary arterial pressure and flow in adult goat under the different respiratory settings with open- and closed-chest condition. We calculated pulmonary input impedance in two respiratory conditions under the anesthetized open-chest positive pressure ventilation (PPV) and the awake spontaneous respiration (SR). Longitudinal impedance in SR showed lower than in PPV. Characteristic impedance in SR was bigger than in PPV. Therefore, we concluded that the pulmonary impedance should be considered for more sophisticated simulation of pulmonary circulatory support devices.
Development of sensorless control system for pediatric pulmonary circulatory assist device using shape memory alloy fibers

Yamada Akihiro, Shiraishi Yasuyuki, Omran Hashem Mohamed, Miura Hidekazu, Tsuboko Yusuke, Yamagishi Masaaki, Homma Dai, Yambe Tomoyuki

Transactions of Japanese Society for Medical and Biological Engineering　52　(0)　O-539-O-540　2014
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.52.O-539 　

ISSN： 1347-443X

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In order to promote the pulmonary circulation after Fontan procedure, we have been developing a pediatric pulmonary circulatory assist device using shape memory alloy (SMA) fibers. In this study, we developed the sensorless control system for the pulmonary circulatory assist device and examined its fundamental functions. The SMA fiber shows a linear relationship between the internal resistance and longitudinal contraction. We measured a change in current of the fiber during the operation. After driving, the current was 1.8A rises from 1.4A due to contraction of the fiber, and peak value was measured at the complete contraction. We could be achieved monitoring of the contractile condition by the current change. It was indicated the system could be reduce of overheating and decrease in contractile force of the device. In the application of the control method, the high-reliability system as the implantable device might be achieved.
Examination of natural esophageal mechanical properties for the design of an artificial esophagus

Taira Yasunori, Homma Dai, Yambe Tomoyuki, Kamiya Kurodo, Shiraishi Yasuyuki, Miura Hidekazu, Shiga Takuya, Hashem Mohamed, Yamada Akihiro, Tsuboko Yusuke, Sano Kyosuke

Transactions of Japanese Society for Medical and Biological Engineering　52　(0)　O-557-O-558　2014
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.52.O-557 　

ISSN： 1347-443X

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In order to promote peristaltic function in the patients with the end stage of esophageal cancer, we have been developing an implantable artificial esophagus. Surgical treatments, such as gastroesophagostomy, are applied for alternative reconstruction in the patients, however, the peristaltic motion will be eliminated. In this study, we focused on the distributed function in the native esophagus and examined stress-strain characteristics from proximal to distal portion using freshly extracted goat's esophagus. Prior to the measurement, we developed a new tension test apparatus. As a result, we could evaluate the circumferential esophageal characteristic variations. Then it was suggested that the circumferential stress analysis might be useful for more sophisticated design of artificial esophageal specifications, which would be consistent with the physiological demand as well as the passive structural effects.
Design diversity in artificial passive-active circulatory support systems

Shiraishi Yasuyuki, Morita Kiyozo, Yamagishi Masaaki, Yi Qian, Yambe Tomoyuki, Miura Hidekazu, Tsuboko Yusuke, Yamada Akihiro, Mohamed Hashem Omran, Shiga Takuya, Katahira Shintaro, Akiyama Masatoshi, Saiki Yoshikatsu

Transactions of Japanese Society for Medical and Biological Engineering　52　(0)　OS-9-OS-10　2014
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.52.OS-9 　

ISSN： 1347-443X

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We have been developing several variations of circulatory assist systems based on nano or micro engineering technologies. One of the special features on the design of these new styles of circulatory assist devices will be a passive controllability according to the native signal transmission and hemodynamic response. In this study, we presented the design features and the research diversity for the development of passive-active circulatory support systems, such as artificial myocardial assist devices, circulatory valves, epi-cardial or vascular support systems.
Analysis of cardiovascular and autonomic nerve response to visual stress for preclinical medicine

Miura Hidekazu, Takasaki Eiko, Yamashige Daiki, Taira Yasunori, Yamada Akihiro, Tsuboko Yusuke, Sano Kyosuke, Shiraishi Yasuyuki, Yambe Tomoyuki

Transactions of Japanese Society for Medical and Biological Engineering　52　(0)　SY-25-SY-26　2014
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.52.SY-25 　

ISSN： 1347-443X

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Stress is an important factor when we consider responses in the cardiovascular and the autonomic nervous systems. After ethical committee allowance, responses in the cardiovascular system and autonomic nerve were evaluated with the individual characteristics. We investigated relationship between responses to the stress and individual characteristics. Healthy adult participants were assessed with type A scale, Beck depression scale, Hostility scale and Japanese Coronary-prone Behavior Scale (JCBS). Participants were showed hateful images and performed a mathematical task (Sudoku). Heart rate (HR), systolic blood pressure (SBP), LF/HF and pulse wave transmission time (PTT) were measured. The maximum value of the cross-correlation coefficients between BP and HR (ρmax BH), BP and PTT (ρmax BT) were analyzed. In both tasks, higher type A scored groups had larger LF/HF, suggesting that the individual characteristics were correlated with the autonomic nervous system. Significant correlation between the Beck depression score and the decrease in PTT and the increase in BP during hateful images were observed. High type A scored or high depression level had the relationship with the stress.
HEMODYNAMIC EFFECTS IN THE ATRIAL CONTRACTION MODEL ON THE TOTAL ARTIFICIAL HEART USING CENTRIFUNGAL BLOOD PUMPS WITH ADULT GOATS

T. Shiga, H. Miura, Y. Shiraishi, M. Yamauchi, T. Yambe

INTENSIVE CARE MEDICINE　39　S365-S365　2013/10

ISSN： 0342-4642

eISSN： 1432-1238
補助人工心臓用経皮的電力伝送システムの高度化に向けた開発研究

三浦英和, 山田昭博, 坪子侑佑, 伊藤拓哉, 志賀卓弥, モハメッド・ハセム・オムラン, 白石泰之, 山家智之

人工臓器　42　(1)　48-49　2013/06/15
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818
乳がん診断支援を目指した弾性率の非線形性を推定する触診ロボットの開発―2本のマニピュレータにより非均一柔軟体物へ付加する幾何学的境界条件の導出―

築根まり子, 波田野麻耶, 野口建彦, 小林洋, 白石泰之, 山家智之, 宮下朋之, 橋爪誠, 藤江正克

ロボティクスシンポジア予稿集　18th　88-95　2013/03/14

ISSN： 1881-7300
1F17 Preliminary study on the development of an implantable renal nerve cooling device for blood pressure control

ITO Takuya, MIURA Hidekazu, SHIGA Takuya, MOHAMED Hashem, YAMADA Akihiro, TSUBOKO Yusuke, SHIRAISHI Yasuyuki, KUMAGAI Hiroo, YAMBE Tomoyuki

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2013　(0)　211-212　2013
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2013.25.211 　
2C02 Improvement of a pulmonary circulatory system for the evaluation of right ventricular outflow tract reconstruction

TSUBOKO Yusuke, YAMAGISHI Masaaki, YAMBE Tomoyuki, SHIRAISHI Yasuyuki, YAMADA Akihiro, MATSUO Satoshi, SAIKI Yoshikatsu, FENG Zhonggang, AKUTSU Toshinosuke, TANAKA Takashi, Umezu Mitsuo

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2013　(0)　315-316　2013
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2013.25.315 　
ポンプ差圧‐流量関係の動特性を利用した補助人工心臓制御

森谷葵, 田中明, 吉澤誠, 白石泰之, 三浦英和, 志賀卓弥, 山田昭博, 小川大祐, 北野智哉, 山家智之

人工臓器(日本人工臓器学会)　41　(2)　S.155-155　2012/11/01
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
補助人工心臓用経皮的電力伝送システムの高度化に向けた開発研究

三浦英和, 山田昭博, 坪子侑祐, 伊藤拓哉, 志賀卓弥, オムランハシムモハメッド, 白石泰之, 山家智之

人工臓器(日本人工臓器学会)　41　(2)　S.184-184　2012/11/01
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
遠心ポンプ型全置換型人工心臓の右心循環の動物実験モデルにおける右心房収縮のモニタリングの検討

志賀卓弥, 三浦英和, 伊藤拓哉, 森谷葵, 坪子侑佑, 山田昭博, 神谷蔵人, ハシムモハメド, 白石泰之, 山家智之

人工臓器(日本人工臓器学会)　41　(2)　S.155-155　2012/11/01
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
心房細動治療のためのPID温度制御法を用いた心房冷却装置開発の基礎検討

伊藤拓哉, 住吉剛忠, 三浦英和, 神谷蔵人, 志賀卓弥, HASHEM Mohammed, 山田昭博, 坪子侑佑, 森谷葵, 大沢上, 近内利明, 白石泰之, 山家智之

人工臓器(日本人工臓器学会)　41　(2)　S.164-164　2012/11/01
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
形状記憶合金を用いた小児用肺循環補助装置における動的駆動制御方法に関する基礎検討

山田昭博, 白石泰之, 三浦英和, 志賀卓弥, ハセムモハメドオムラン, 神谷蔵人, 坪子侑佑, 森谷葵, 伊藤拓哉, 劉金龍, 銭逸, 山家智之, 山岸正明, 本間大

人工臓器(日本人工臓器学会)　41　(2)　S.134-134　2012/11/01
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818

eISSN： 1883-6097
乳がんのPreloading穿刺手法における幾何学的影響の検討

波田野麻耶, 小林洋, 鈴木麻記子, 白石泰之, 山家智之, 橋爪誠, 藤江正克

日本コンピュータ外科学会誌　14　(3)　368-369　2012/10/05

ISSN： 1344-9486
非線形弾性に基づく乳がん診断支援システムの開発~ロボットマニピュレータによる触診時の乳房変形解析~

築根まり子, 小林洋, 宮下朋之, 白石泰之, 山家智之, 橋爪誠, 藤江正克

日本コンピュータ外科学会誌　14　(3)　206-207　2012/10/05

ISSN： 1344-9486
乳がん診断支援における弾性率の非線形性を計測する触診ロボットの開発(2本の圧子を用いた圧縮方法の有限要素解析による検討)

築根まり子, 小林洋, 宮下朋之, 白石泰之, 山家智之, 橋爪誠, 藤江正克

日本機械学会年次大会講演論文集(CD-ROM)　2012　ROMBUNNO.J165034　2012/09/08
心房冷却による心房細動停止効果の熱力学的検討

古賀千尋, 住吉剛忠, 三浦英和, 劉紅箭, 神谷蔵人, 志賀卓弥, MOHAMMED Hashem, 橋本尚, 山田昭博, 大沢上, 佐藤尚, 白石泰之, 山家智之

生体医工学　50　(4)　366-366　2012/08/10
Publisher: 日本生体医工学会
ISSN： 1347-443X

eISSN： 1881-4379
左室乳頭筋モデルによる僧帽弁機能の基礎検討

橋本尚, 白石泰之, SUGAI Telma Keiko, 志賀卓弥, 古賀千尋, 山田昭博, 坪子侑佑, 三浦英和, 西條芳文, 山家智之, 本間大

生体医工学　50　(4)　367-367　2012/08/10
Publisher: 日本生体医工学会
ISSN： 1347-443X

eISSN： 1881-4379
新しい小児用肺動脈弁改良設計のための逆解析の試み

坪子侑佑, 鈴木一郎, SUGAI Telma Keiko, 山田昭博, 北野智哉, 志賀卓弥, 神谷蔵人, 白石泰之, 山家智之, 阿久津敏乃介, 馮忠剛, 梅津光生, 宮崎隆子, 山岸正明

生体医工学　50　(4)　370-370　2012/08/10
Publisher: 日本生体医工学会
ISSN： 1347-443X

eISSN： 1881-4379
小児用肺循環補助装置の駆動方法に関する検討

山田昭博, 白石泰之, Sugai Telma Keiko, 三浦英和, 古賀千尋, 橋本尚, 坪子侑佑, 山家智之, 山岸正明, 本間大

生体医工学　50　(4)　367-367　2012/08
Publisher: (公社)日本生体医工学会
ISSN： 1347-443X

eISSN： 1881-4379
血行力学的機能に関する新規設計の小児肺動脈弁のbulging sinusの影響の医工学的分析(Engineering analysis of the effects of bulging sinus in a newly designed paediatric pulmonary heart valve on hemodynamic function) Invited

鈴木一郎, 矢部翔太, 末永健, Sugai Telma Keiko, 坪子侑佑, 西條芳文, 吉澤誠, 亀山剛義, 白石泰之, 山家智之, 馮忠剛, 岡本吉弘, 田中隆, 梅津光生, 宮崎隆子, 山岸正明

人工臓器　41　(1)　59-61　2012/06
Publisher: (一社)日本人工臓器学会
ISSN： 0300-0818
Engineering Analysis of the Effects of Bulging Sinus in a Newly Designed Paediatric Pulmonary Heart Valve on Hemodynamic Function Invited

鈴木一郎, 矢部翔太, 末永健, SUGAI Telma Keiko, 坪子侑佑, 西條芳文, 吉澤誠, 亀山剛義, 白石泰之, 山家智之, 馮忠剛, 岡本吉弘, 田中隆, 梅津光生, 宮崎隆子, 山岸正明

東北医学雑誌　124　(1)　120-124　2012/06

ISSN： 0040-8700
Blood Flow Structure in Patients with Dilated Cardiomyopathy Studied using Echo-dynamography

亀山剛義, 山家智之, 白石泰之, 西條芳文, 田中元直

日本臨床生理学会雑誌　42　(3)　2012

ISSN： 0286-7052
8E12 Parametric estimation of modeling of an ePTFE paediatric pulmonary valve function using transvalvular hemodynamic data

TSUBOKO Yusuke, SUGAI Telma Keiko

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2012　(0)　_8E12-1_-_8E12-2_　2012
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2012.24._8E12-1_ 　
Preliminary study on the effect of extra-cardiac conduit contractile pressure on the mechanical Fontan circulation support

YAMADA Akihiro, SHIRAISHI Yasuyuki, SUGAI Telma Keiko, MIURA Hidekazu, SHIGA Takuya, HASHEM Mohamed Omran, KOGA Chihiro, HASHIMOTO Hisashi, TSUBOKO Yusuke, YAMBE Tomoyuki, YAMAGISHI Masaaki, HOMMA Dai

2011　(67)　41-44　2011/11/24
ARTIFICIAL MUSCLE FOR THE ACTUATOR OF THE ARTIFICIAL INTERNAL ORGANS

T. Yambe, Y. Shiraishi, H. Miura, M. Akiyama, Y. Saiki, T. K. Sugai

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS　34　(8)　613-613　2011/08

ISSN： 0391-3988
8F-07 Preliminary study on the effect of papillary tension on valvular leakage for the development of a new artificial papillary muscle using shape memory alloy fiber

HASHIMOTO Hisashi, SHIRAISHI Yasuyuki, SUGAI Telma KEIKO, KONNO Satoshi, MIURA Hidekazu, SAIJO Yoshifum, YAMBE Tomoyuki, HOMMA Dai

2010　(23)　109-110　2011/01/07
Publisher: The Japan Society of Mechanical Engineers
体外からのエネルギー伝送による超小型化補助循環装置の開発

早津幸弘, 白石泰之, 秋山正年, 齋木佳克, 山家智之

General Thoracic and Cardiovascular Surgery　59　(Supplement)　2011

ISSN： 1863-6705
8F-04 Acute experiments of the total artificial heart with the continuous flow pumps

CHEN Jiongxun, YAMBE Tomoyuki, MIURA Hidekazu, SHIRAISHI Yasuyuki, LIU Hongjian, SUGAI Telma Keiko, YABE Shota, YAMADA Akihiro, KOGA Chihiro, HASHIMOTO Hisashi

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2010　(0)　105-106　2011
Publisher: The Japan Society of Mechanical Engineers
8F-05 Development of the Novel Support Mechanism for the Total Cavopulmonary Connection by using Shape-Memory Alloy Fibers

YAMADA Akihiro, HASHIMOTO Hisashi, MORIYAMA Masaki, KAKEGAWA Ryoma, YAMASAKI Koji, SHINGAKI Kiyotaka, MOCHIZUKI Syuichi, YAMBE Tomoyuki, HOMMA Dai, SHIRAISHI Yasuyuki, YAMAGISHI Masaaki, SUGAI Telma Keiko, MIURA Hidekazu, LIU Hongjian, YABE Shota, CHEN Jiongxun, KOGA Chihiro

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2010　(0)　107-108　2011
Publisher: The Japan Society of Mechanical Engineers
9F-12 Development of an implantable hypothermia device for atrial defibrillation

KOGA Chihiro, SHIRAISHI Yasuyuki, YAMBE Tomoyuki, SUMIYOSHI Takenori, OSAWA Noboru, SATO Naoshi, SUGAI Telma Keiko, CHEN Jiongxun, YAMADA Akihiro, HASHIMOTO Hisashi, YABE Shota, KONNO Satoshi, MIURA Hidekazu, LIU Hongiian

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2010　(0)　413-414　2011
Publisher: The Japan Society of Mechanical Engineers
Preliminary study on the development of a new artificial papillary muscle using shape memory alloy fiber

HASHIMOTO Hisashi, SHIRAISHI Yasuyuki, SUGAI Telma Keiko, KONNO Satoshi, MIURA Hidekazu, SAIJO Yoshifum, YAMBE Tomoyuki, HOMMA Dai

2010　(45)　13-16　2010/11/20
Development of the pulmonary circulation assist device for the total cavopulmonary connection (TCPC) with shape-memory alloy fibers

YAMADA Akihiro, SHIRAISHI Yasuyuki, SUGAI Telma Keiko, MIURA Hidekazu, LIU Hongjian, YABE Shota, CHEN Jiongxun, KOGA Chihiro, HASHIMOTO Hisashi, YAMBE Tomoyuki, MORIYAMA Masaki, KAKEGAWA Ryoma, MOCHIZUKI Shuichi, YAMAGISHI Masaaki, HOMMA Dai

電気学会研究会資料. LD, リニアドライブ研究会　2010　(45)　7-11　2010/11/20
DIET CONTROL EXPANDING CAPSULE USING TRANSCUTANEOUS ENERGY TRANSMISSION

T. Yambe, Y. Shiraishi, H. Miura, Y. Saiki, K. Fukushima, M. Yoshizawa

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS　33　(7)　455-455　2010/07

ISSN： 0391-3988
0406 Preliminary examination of an engineering control for hemodynamic assistance by the artificial myocardium using shape memory alloy fibre

SATO Yuta, UMEZU Mitsuo, FUJIMOTO Tatsuo, SHIRAISHI Yasuyuki, MIURA Hidekazu, KONNO Satoshi, YAMBE Tomoyuki, KANEKO Yoshikazu, SUGAI Telma Keiko, YABE Shota, SAIJO Yoshifumi, BABA Atsushi, Homma Dai

2009　(22)　58-58　2010/01/08
Publisher: The Japan Society of Mechanical Engineers
Bulging sinusを有するePTFE心臓代用弁の工学的評価

白石泰之, 鈴木一郎, 矢部翔太, SUGAI Telma K, 山田昭博, 亀山剛義, 金子芳一, 北野智哉, 田中隆, 金野敏, 西條芳文, 梅津光生, 宮崎隆子, 山岸正明, 山家智之

人工臓器(日本人工臓器学会)　39　(2)　2010

ISSN： 0300-0818
螺旋流入路遠心ポンプを用いた完全人工心臓の開発

三浦英和, 白石泰之, 矢部翔太, SugaiTelma Keiko, 劉紅剪, 馬場敦, 山家智之

生体医工学　48　(3)　314-314　2010
機械的な人工補助循環下の圧反射感受性解析の試み

劉紅箭, 白石泰之, 三浦英和, SugaiTelma Keiko, 矢部翔太, 山家智之

生体医工学　48　(3)　313-313　2010
肥満外科と同様の効果が期待できる肥満制御用の胃内拡張カプセル

山家智之, 白石泰之, 三浦英和, 佐藤文博

肥満研究　16　(Suppl.)　142-142　2010
人工臓器医工学を用いた胃内拡張カプセルによる自律神経系を介した食欲抑制システム

山家智之, 白石泰之, 三浦英和

日本自律神経学会総会プログラム・抄録集　63回　164-164　2010
心房細動治療用冷却新デバイス開発の試み

古賀千尋, 住吉剛忠, スガイ・テルマ・ケイコ, 金野敏, 三浦英和, 劉紅箭, 陳炯旬, 山田昭博, 橋本尚, 矢部翔太, 白石泰之, 大沢上, 山家智之, 佐藤尚

人工臓器　39　(2)　S156-S156　2010
人工心筋技術を応用した新しい人工乳頭筋開発設計の基礎検討

橋本尚, 白石泰之, SugaiK.T, 三浦英和, 矢部翔太, 劉紅箭, 陳炯旬, 古賀千尋, 山田昭博, 西條芳文, 山家智之

人工臓器　39　(2)　S150-S150　2010
形状記憶合金線維を用いた小児用肺循環補助能動グラフト開発の基礎検討

山田昭博, 白石泰之, 山岸正明, SugaiTelma K, 三浦英和, 劉紅箭, 矢部翔太, 陳炯旬, 古賀千尋, 橋本尚, 森山真樹, 掛川竜馬, 山崎晃司, 新垣清貴, 望月修一, 山家智之, 本間大

人工臓器　39　(2)　S124-S124　2010
左心補助人工心臓における循環動態及び脈波伝播時間の非線形解析

劉紅箭, 白石泰之, 三浦英和, SugaiTelma K, 矢部翔太, 山家智之

人工臓器　39　(2)　S123-S123　2010
急性動物実験による新しい定常流完全置換型人工心臓の基礎検討

陳炯旬, 三浦英和, 白石泰之, SugaiTelma K, 劉紅箭, 矢部翔太, 山田昭博, 古賀千尋, 橋本尚, 山家智之

人工臓器　39　(2)　S103-S103　2010
究極の人工心臓?=無拍動全置換型人工心臓の可能性らせん流入構造をもつ遠心血液ポンプによる無拍動完全置換型人工心臓の開発

三浦英和, 陳炯旬, 白石泰之, 矢部翔太, スガイ・テルマ・ケイコ, 劉紅箭, 馬場敦, 山家智之

人工臓器　39　(2)　S21-S21　2010
A102 Evaluation of hemodynamic characteristics of the newly designed paediatric pulmonary heart valve by using a high speed video camera

YABE Shota, SUZUKI Ichiro, Sugai Telma Keiko, SAIJO Yosifumi, MIURA Hidekazu, LIU Hong Jian, KONNO Satoshi, SHIRAISHI Yasuyuki, YAMBE Tomoyuki, TANAKA Takashi, UMEZU Mitsuo, MIYAZAKI Takako, YAMAGISHI Masaaki

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2009　(20)　5-6　2009/11/06
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
Basic study on the sophisticated control for the intelligent artificial myocardium

SHIRAISHI Yasuyuki, MIURA Hidekazu, YAMBE Tomoyuki, SUGAI Telma Keiko, SAIJO Yoshifumi, SATO Yuta, FUJIMOTO Tetsuo, UMEZU Mitsuo, BABA Atsushi, FUKUNAGA Kazuyoshi, TANAKA Akira, HOMMA Dai

2009　(34)　37-42　2009/10/20
Preliminary study on novel centrifugal blood pump for total artificial heart

MIURA Hidekazu, SHIRAISHI Yasuyuki, YABE Shota, SUGAI Telma Keiko, LIU Hong Jian, YAMBE Tomoyuki

2009　(34)　33-36　2009/10/20
510 Preliminary study on total artificial heart using rotary blood pumps

MIURA Hidekazu, SHIRAISHI Yasuyuki, YABE Shota, SUGAI Telma Keiko, LIU Hong Jian, YAMBE Tomoyuki

2009　(45)　147-148　2009/09/26
Publisher: The Japan Society of Mechanical Engineers
509 Basic characteristics of the newly designed paediatric pulmonary circulatory simulator

YABE Shota, SUZUKI Ichiro, SUGAI Telma Keiko, SAIJO Yosifumi, MIURA Hidekazu, LIU Hong Jian, KONNO Satoshi, SHIRAISHI Yasuyuki, YAMBE Tomoyuki, TANAKA Takashi, UMEZU Mitsuo, MIYAZAKI Takako, YAMAGISHI Masaaki

2009　(45)　145-146　2009/09/26
Publisher: The Japan Society of Mechanical Engineers
508 Preliminary study on the new bioengineering approach for surgical planning of ventricular reconstruction

SHIRAISHI Yasuyuki, LIN Hui, SUGAI Telma Keiko, UEMATSU Miyuki, SAIJO Yoshifumi, TANAKA Akira, UMEZU Mitsuo, YAMBE Tomoyuki, TABAYASHI Koichi

2009　(45)　143-144　2009/09/26
Publisher: The Japan Society of Mechanical Engineers
Pulse wave velocity (PWV) と Cardio Ankle Vascular Index (CAVI) ―数理モデルから臨床、予防医学への展開―

山家智之, 白石泰之, 今野敏, 劉紅箭, 川島隆太, 吉澤誠, 早瀬敏幸, 阿部恒之, ビクター・ミラーゲン, ユーリ・コバレフ, イリーナ・ミリャジーナ, 侯暁彫, 張秀敏

日本臨床生理学会雑誌　39　(4)　189-213　2009/07
Publisher: 日本臨床生理学会
多次元の血圧反射機能感受性定量診断 (心臓リハビリテーション)

山家智之, 金野敏, 西條芳文, 白石泰之, 仁田新一, 上月正博, 吉澤誠, 杉田典大, 田中明, 山口済, 片平美明, 秋野能久, 柴田宗一, 渡辺誠, 三引義明, 大沢上, 佐藤尚

心臓リハビリテーション　14　(1)　108-114　2009/02
139 Mechanical design of the totally implantable artificial myocardial assist device by using shape memory alloy fibre

SHIRAISHI Yasuyuki, SAKATA Ryo, SATO Yuta, KONNO Satoshi, SUGAI Telma Keiko, BABA Atsushi, FUJIMOTO Tetsuo, UMEZU Mitsuo, IMACHI Kou, SAIJO Yoshifumi, YAMBE Tomoyuki, Homma Dai

2008　(21)　307-308　2009/01/22
Publisher: The Japan Society of Mechanical Engineers
Aromaによる血圧反射機能感受性制御の可能性

山家智之, 白石泰之, 羅雲, 鄭徳詠, 吉澤誠

自律神経　46　(2)　2009

ISSN： 0288-9250
全置換型遠心式人工心臓開発とその循環制御

山家智之, 三浦英和, 白石泰之, 吉沢誠, 田中明, 阿倍裕輔

循環制御　30　(抄録集)　87-87　2009
ヘリカルフロー動圧軸受無拍動ポンプを用いた小児用全置換型人工心臓

山家智之, 三浦英和, 白石泰之, 田林晄一

日本心臓病学会誌　4　(Suppl.I)　487-487　2009
無拍動全置換型人工心臓の血圧制御

山家智之, 三浦英和, 白石泰之, 田中明, 吉沢誠

日本高血圧学会総会プログラム・抄録集　32回　307-307　2009
小児用ePTFE製肺動脈心臓代用弁の評価用シミュレーションシステム開発と基礎特性

矢部翔太, 鈴木一郎, SugaiTelma Keiko, 三浦英和, 金野敏, 劉紅箭, 白石泰之, 西條芳文, 山家智之, 宮崎隆子, 山岸正明, 田中隆, 梅津光生

人工臓器　38　(2)　S-135　2009
完全人工心臓のための新しい構造の遠心血液ポンプに関する基礎的研究

三浦英和, 白石泰之, 矢部翔太, SugaiTelma K, 劉紅箭, 山家智之

人工臓器　38　(2)　S-91　2009
補助人工心臓による循環補助下の脈波伝導時間解析の試み

劉紅箭, 白石泰之, 三浦英和, SugaiTelma Keiko, 矢部翔太, 金子芳一, 山家智之

人工臓器　38　(2)　S-77　2009
脈のない人工心臓と，脈の診断

山家智之, 白石泰之, 金野敏, 馬場篤志, 井街宏, 田林晄一, 西條芳文, 杉田典大, 吉沢誠, 上月博, 阿部裕輔, 斎藤逸郎, 磯山隆, 山崎健二, 北野智哉, 山崎俊一, 亀山剛義, 秋野能久, 山口済, 片平美明, 柴田宗一, 大沢上, 佐藤尚

宮城県医師会報　755　(755)　12　2008/12/01
IABP駆動装置を用いたSV Pump補助人工心臓システムの拍出性能評価

久米嶺, 古里正光, 石澤祐馬, 白石泰之, 岩崎清隆, 梅津光生

人工臓器(日本人工臓器学会)　37　(2)　S.75　2008/10/01

ISSN： 0300-0818
1E3-1 MINIATURE-SIZED SENSOR FOR MEASURING BLOOD PRESSURE

AKIYAMA Masaki, FUJIMOTO Tetsuo, TAKEHANA Yoshito, MASUDA Hiroshi, UMEZU Mitsuo, SHIRAISHI Yasuyuki

The JSME Symposium on Welfare Engineering　2008　122-125　2008/09/17
Publisher: The Japan Society of Mechanical Engineers

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Measuring blood pressure is one of the most important processes for evaluating hemodynamics. Some methods for measuring blood pressure are widely used, however there are few devices which can measure blood pressure of patients continuously and precisely without any invasive treatment. If the blood pressure can be measured on the skin continuously in real time, the information for safely detecting changes in hemodynamics of patients will be obtained. Therefore, a miniature-sized pressure sensor, which can measure blood pressure on the skin, was developed and experiments were conducted to reveal the utility of the newly developed sensor.
1E3-5 Improvement of the artificial myocardial assistance for chronic animal experiment

SATO Yuta, SHIRAISHI Yasuyuki, SAKATA Ryo, LIN Hui, TANAKA Takashi, UMEZU Mitsuo, KONNO Satoshi, SAIJO Yoshifumi, SUGAI Telma Keiko, YOSHIZAWA Makoto, YAMBE Tomoyuki, BABA Atsushi, MASUMOTO Noriyasu, FUJIMOTO Tetsuo, Homma Dai

The JSME Symposium on Welfare Engineering　2008　135-136　2008/09/17
Publisher: The Japan Society of Mechanical Engineers
ESH2008サテライト欧州における動脈スティッフネス計測標準化のための国際ミーティング― 大学病院とプライベートクリニックにおける動脈硬化follow ―

山家智之, 劉紅煎, 金野敏, 白石泰之, 宋虎振, 羅雲, 山口済, 片平美明, 柴田宗一, 大沢上, 杉田典大, 吉澤誠, 早瀬敏行, 上月正博, 宗像正徳, 張秀敏, I. A. Milyagina, J. Zaloudic, B. Fiser, J. Siegelova, P. Dobsak

エレクトロニクスの臨床　1-30　2008/08/25
Publisher: 株式会社エム・イー・タイムス
血液循環系の模擬循環システム--フルードパワー技術の医工学的利用 (特集こんなところにもフルードパワー)

白石泰之, 梅津光生

油空圧技術　47　(8)　12-16　2008/08
Publisher: 日本工業出版
ISSN： 0914-6253
Effect of the mechanical support system assistance on the arterial elasticity - Prevention of the atherosclerosis and hypertension

T. Yambe, Y. Abe, K. Tabayashi, E. Okamoto, Y. Shiraishi

JOURNAL OF HYPERTENSION　26　S437-S438　2008/06

ISSN： 0263-6352
日本製臨床用遠心型埋め込み式補助人工心臓の世界最長動物実験 (東北医学雑誌)

山家智之, 白石泰之, 羅雲, 井街宏, 山崎健二, 北野智哉, 山崎俊一

東北医学雑誌　120　(1)　77-79　2008/06

ISSN： 0040-8700
新たなるナノテクノロジーとは? ナノテク人工心筋開発 (循環器専門医)

山家智之, 白石泰之, 田林晄一

循環器専門医　16　(1)　75-81　2008/03

DOI： 10.1253/jjcsc.16.1_75 　
637 Mechanical analysis of morphological structure of a heart for more sophisticated design of the artificial myocardium

SHIRAISHI Yasuyuki, SAIJO Yoshifumi, YAMBE Tomoyuki, SHIBATA Muneichi, WADA Yumiko, SAKATA Ryo, WATABE Tomoki, UMEZU Mitsuo, FUJIMOTO Tetsuo, BABA Atsushi, TABAYASHI Koichi, Homma Dai

2007　(20)　433-434　2008/01/24
Publisher: The Japan Society of Mechanical Engineers
115 Numerical Simulation of Blood Flow in Left Atrium Modeled with Magnetic Resonance Imaging

KANKE Yusuke, HAYASE Toshiyuki, YAMBE Tomoyuki, SHIBATA Muneichi, SHIRAISHI Yasuyuki

2007　(20)　29-30　2008/01/24
Publisher: The Japan Society of Mechanical Engineers
MERAモノピボット遠心血液ポンプの血液適合性評価

丸山修, 吉田文彦, 矢田亨, 小阪亮, 西田正浩, 山本好宏, 桑名克之, 白石泰之, 山家智之, 馬場敦, 井街宏, 筒井達夫, 山根隆志

人工臓器(日本人工臓器学会)　37　(2)　2008

ISSN： 0300-0818
The basic study for quantification of anastomotic technique of coronary artery bypass grafting

OKI E., PARK Y., KANEMITSU N., SHIRAISHI Y., AZUMA T., OHTSUBO S., IWASAKI K., UMEZU M.

9　(3)　250-251　2007/12/30

ISSN： 1344-9486
冠動脈バイパス手術における血管吻合手技の定量化に向けた基礎検討

沖恵理子, PARK Y, 金光直彦, 白石泰之, 東隆, 大坪真也, 岩崎清隆, 梅津光生

コンピュータ支援画像診断学会大会・日本コンピュータ外科学会大会合同論文集　17th-16th　83-84　2007/11/02
Artificial Myocardial Assistance using the Sophisticated Shape Memory Alloy Fibre Based on Engineering Approach for Cardiac Mechanics

SHIRAISHI Yasuyuki, YAMBE Tomoyuki, SAIJO Yoshifumi, SHIBATA Muneichi, MASUDA Shinya, TABAYASHI Koichi, UMEZU Mitsuo, HOMMA Dai

電気学会研究会資料. LD, リニアドライブ研究会　2007　(32)　85-88　2007/10/25
A111 Mechanical simulation for myocardial contractile assistance based on controllability of a sophisticated shape memory alloy fibre

SAKATA Ryo, SHIRAISHI Yasuyuki, WADA Yumiko, WATABE Tomoki, UEMATSU Miyuki, TANAKA Takashi, PARK Young Kwang, UMEZU Mitsuo, SEKINE Kazumitsu, KONNO Satoshi, SAIJO Yoshifumi, YAMBE Tomoyuki, TANAKA Akira, YOSHIZAWA Makoto, MASUMOTO Noriyasu, FUJIMOTO Tetsuo, HOMMA Dai

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2007　(18)　21-22　2007/10/05
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
脳神経機能制御アクチュエータ (電気学会産業技術応用部門講演会論文集)

山家智之, 白石泰之, 圓山重直

電気学会産業技術応用部門講演会論文集　33-36　2007/08
体内埋込み機器のための始動トリガの簡易的な伝送に関する検討

角張泰之, 佐藤文博, 松木英敏, 関根一光, 白石泰之, 山家智之, 佐藤忠邦

電気関係学会東北支部連合大会講演論文集　2007　2007
人工心筋収縮構造制御による補助効率最適化に関する基礎検討

白石泰之, 山家智之, 関根一光, 西條芳文, 金野敏, 仁田新一, 和田由美子, 坂田亮, 梅津光生, 小川大祐, 佐藤文博, 角張泰之, 田中明, 吉澤誠, 本間大

日本生体医工学会大会プログラム・論文集(CD-ROM)　46th　2007
蠕動運動機能をもつ人工食道のための胃部留置型経皮的電力伝送装置の開発

角張泰之, 佐藤文博, 松木英敏, 関根一光, 白石泰之, 山家智之, 佐藤忠邦

日本生体医工学会大会プログラム・論文集(CD-ROM)　46th　2007
形状記憶合金を応用した消化管蠕動運動補助装置

関根一光, 山家智之, 西條芳文, 白石泰之, 松木英敏, 佐藤文博, 角張泰之, 前田剛, 中澤文男

日本生体医工学会大会プログラム・論文集(CD-ROM)　46th　2007
生体心臓の構造を考慮した人工心筋開発の試み

白石泰之, 山家智之, 関根一光, 西條芳文, 金野敏, 仁田新一, 和田由美子, 坂田亮, 伊藤慎二, 植松美幸, PARK Youngkwang, 田中隆, 梅津光生, 小川大祐, 角張泰之, 佐藤文博, 田中明, 吉澤誠, 増本憲泰, 藤本哲男, 本間大, 馬場敦, 井街宏, 佐々田比呂志, 田林晄一

バイオエンジニアリング講演会講演論文集　19th　2007

ISSN： 1348-2920
340 Development of linear actuator as a peristaltic motion assist device

Sekine Kazumitsu, Nakazawa Fumio, Shiraishi Yasuyuki, Yambe Tomoyuki, Saijo Yoshifumi, Ohta Makoto, Hori Yoshio, Matsuki Hidetoshi, Sato Fumihiro, Maeda Tsuyoshi

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2006　(0)　336-337　2007
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmebio.2006.19.336 　
磁性流体軸シールのMEDOS DELTASTREAM血液ポンプへの応用及び慢性動物実験評価

関根一光, 迫田大輔, 白石泰之, 山家智之, 廣田泰丈, 津田史郎, REUL H, 三田村好矩

磁性流体連合講演会講演論文集　2006-12　53-56　2006/12/07
B102 Design improvement of a newly designed artificial myocardial belt

WADA Yumiko, SHIRAISHI Yasuyuki, ITOH Shinji, SAKATA Ryo, UEMATSU Miyuki, TANAKA Takashi, PARK Young Kwang, UMEZU Mitsuo, SEKINE Kazumitsu, KONNO Satoshi, SAIJO Yoshifumi, YAMBE Tomoyuki, Nitta Shinichi, TANAKA Akira, YOSHIZAWA Makoto, MASUMOTO Noriyasu, FUJIMOTO Tetsuo, HOMMA Dai

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2006　(17)　43-44　2006/11/10
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
Development of peristaltic motion assist device for using helicoidal shape memory alloy against digestive organs cancer

SEKINE Kazumitsu, YAMBE Tomoyuki, SHIRAISHI Yasuyuki, SAIJO Yoshifumi, HORI Yoshio, MATSUKI Hidetoshi, SATO Fumihiro, NITTA Shin-ichi, MAEDA Tsuyoshi

2006　(48)　69-73　2006/10/26
100MHz超音波による肝組織の3次元イメージング

西条芳文, 岡田長也, 小林和人, 穂積直裕, SANTOS FILHO Esmeraldo Dos, 白石泰之, 関根一光, 山家智之

超音波医学　33　S315　2006/04/15

ISSN： 1346-1176
未来医学事典極細の形状記憶合金を用いた機械式人工心筋ユニットの開発 (未来医学)

白石泰之

未来医学　(21)　68-71　2006/03
Publisher: 未来医学研究会
ISSN： 0910-9870
経食道心エコーによる左室補助装置装着患者の心機能評価

西條芳文, 齋木佳克, 井口篤志, 田林晄一, 白石泰之, 関根一光, 山家智之

日本生体医工学会大会プログラム・論文集　45th　2006

ISSN： 1347-443X
左心補助装置装着症例の術中経食道心エコー所見

西條芳文, 齋木佳克, 井口篤志, 田林晄一, 白石泰之, 関根一光, 山家智之

日本心エコー図学会学術集会抄録集　17th　2006
B117 Development of a totally-implantable artificial myocardium using a shape memory alloy fiber

NAGATOSHI Jun, ITOH Shinji, UEMATSU Miyuki, TANAKA Takashi, UMEZU Mitsuo, SHIRAISHI Yasuyuki, SEKINE Kazumitsu, KONNO Satoshi, SAIJO Yoshifumi, YAMBE Tomoyuki, TANAKA Akira, YOSHIZAWA Makoto, MASUMOTO Noriyasu, FUJIMOTO Tetsuo, HOMMA Dai

Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2005　(16)　77-78　2005/11/08
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2939
ALTERNATIVE MAGNETIC STIMULATION ON PERIPHERAL CIRCULATION FOR REGENERATIVE MEDICINE

YAMBE T., SEKINE K., SHIRAISHI Y., SAIJO Y, KONNO S., MARUYAMA M., NITTA S, TABAYASHI K., INOUE A

25　(1)　10-10　2005/06/10

ISSN： 0916-6238
冠動脈バイパス手術吻合法に対する工学的観点からの評価

末弘淳一, 川合潤子, 有田誠, 白石泰之, 岩崎清隆, 田中隆, 新浪博, 阿久津敏乃介, 安藤譲二, 梅津光生

日本ME学会大会論文集　44th　458　2005/04/25
拍動に伴う心臓表面の領域変化の光学式計測

植松美幸, 白石泰之, 関根一光, 山家智之, 西条芳文, 武藤俊介, PARK Y, 安藤隼人, 松本徹, 武田朴, 岩崎清隆, 梅津光生

日本ME学会大会論文集　44th　457　2005/04/25
Project Artifical myocardium

Tomoyuki Yambe, Yasuyuki Shiraishi, Tasuku Yamaguchi, Mune-ichi Shibata, Shinichi Nitta, Makoto Yoshizawa, Akira Tanaka, Ken-ichi Abe, Fumihiro Sato, Hidetoshi Matsuki, Yoichi Haga, Masayoshi Esashi, Shigenao Maruyama, Toshiyuki Takagi, Masaru Higa, Yun Luo

Journal of Advanced Science　17　(1&2)　118-125　2005

DOI： 10.2978/jsas.17.118 　

ISSN： 0915-5651
血液循環モデルの人工臓器評価への応用

梅津光生, 岩崎清隆, 白石泰之, 有田誠, 田中隆, 堀切芳一, QIAN Y, 野口康雄

日本ME学会大会論文集　43rd　412　2004/05/19
ナノテクを応用した人工臓器開発の新しい地平

山家智之, 堀義生, 井口篤志, 芳賀洋一, 吉澤誠, 松木英敏, 川野恭之, 高木敏行, 圓山重直, 段旭東, 井街宏, 佐藤英明, 久保豊, 梅津光生, 前田剛, 白石泰之, 田林晄一, 江刺正喜, 田中明, 佐藤文博, 羅雲, 早瀬敏幸, 王慶田, 仁田新一, 佐々田比呂志, 岡本英治, 大坂元久, 本間大

未来材料　4　(8)　30-37　2004
形状記憶合金アクチュエータを応用した人工食道開発

山家智之, 堀義生, 渡邉誠, 白石泰之, 井口篤志, 田林晄一, 芳賀洋一, 江刺正喜, 吉澤誠, 田中明, 松木英敏, 佐藤文博, 川野恭之, 羅雲, 高木敏行, 早瀬敏幸, 圓山重直, 仁田新一, 佐々田比呂志, 佐藤英明, 宮田剛, 里見進, 本間大, 前田剛

日本AEM学会誌　12　(2)　94-99　2004
Publisher: 日本AEM学会
ISSN： 0919-4452
新しい人工心筋システムの開発

白石泰之, 山家智之, 関根一光, 西條芳文, 渡邉誠, 柴田宗一, 山口済, 王慶田, 段旭東, 劉紅箭, 仁田新一, 岡本英治, 吉澤誠, 田中明, 小川大祐, 佐藤文博, 松木英敏, 川野聡恭, 羅雲, 堀義生, 田林晄一, 高木敏行, 早瀬敏幸, 圓山重直, 佐々田比呂志, 梅津光生, 本間大

日本AEM学会誌　12　(2)　87-93　2004
Publisher: 日本AEM学会
ISSN： 0919-4452
ナノテクノロジーを応用した人工臓器開発－ナノテク人工食道とナノテク人口心筋－

山家智之, 堀義生, 白石泰之, 井口篤志, 田林晄一, 芳賀洋一, 江刺正善, 吉澤誠, 田中明, 松木英敏, 佐藤文博, 川野恭之, 羅雲, 高木敏行, 早瀬敏幸, 圓山重直, 王慶田, 段旭東, 仁田新一, 佐々田比呂志, 佐藤英明, 岡本英治, 久保豊, 大坂元久, 梅津光生, 本間大, 前田剛

ナノ学会会報　2　(2)　103-112　2004
Development and evaluation of artificial organs for blood circulatory system

藤本哲男, 川口大輔, 白石泰之, 岩崎清隆, 梅津光生

日本機械学会関東支部総会講演会講演論文集　9th　(9)　101-102　2003/03/13
Publisher: The Japan Society of Mechanical Engineers

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A stentless valvular bioprosthetsis using a porcine aortic root has been shown to yield high performance in terms of durability, hydrodynamic characteristics and biocompatibility. The purpose of this study is to show the effect of the difference in methods of implanting the bioprosthesis at the aortic position on the hydrodynamic characteristics of the bioprosthesis. Subcoronary and Full-root techniques, that are mainly used for implanting the bioprosthesis into the aorta, were simulated under conditions in which the degree of elasticity around the bioprosthesis at the aortic root position was varied in a mock circulatory system. As a result, the forward flow at the bioprosthesis in the case of the Subcoronary was 11% greater than that of the Full-root. The variation in the elasticity around the bioprosthesis was suggested to influence the hydrodynamic characteristics.
心臓血管外科支援用循環シミュレータ

梅津光生, 内田浩司, 有田誠, 岩崎清隆, 白石泰之, 桜井靖久

バイオエンジニアリング講演会講演論文集　14th　(14)　53-54　2002/03/01
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-2920
W403 Variation of cardiac work caused by the artificial vascular graft implantation

SUZUKI Youhei, FUJIMOTO Tetsuo, SHIRAISHI Yasuyuki, ARITA Makoto, UMEZU Mitsuo

2001　339-339　2001/08/03
Publisher: The Japan Society of Mechanical Engineers
ISSN： 1348-0235

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Recently, the artificial vascular grafts are generally implanted in the patients with serious arterial disease. The purpose of this study is to investigate a cardiac performance in the patient who was implanted an artificial graft, focusing on the cardiac work. In this study, the authors obtained the hemodynamic data from animal experiment and also evaluated these data using a mechanical circulatory simulator (MCS) as well as a mathematical model consequently. As a result, it was indicated that the variation of cardiac work caused by the elastic property or the shape of the vascular graft could be defined.The systematic analysis might be enable to support the surgical operation, in which the procedure is usually selected from experience of surgeons.
高齢者の血行動態を再現する血液循環シミュレータ開発のための検討

白石泰之, 梅津光生, 有田誠

ヒュ-マンサイエンス　13　(2)　95-101　2001/03
Publisher: 早稲田大学人間総合研究センタ-
ISSN： 0914-8973
Hydrodynamic characteristics of a bi-leaflet heart valve with a rotational disk movement.

中田紀彦, 梅津光生, 岩崎清隆, 白石泰之, 藤本哲男, 小林晴良, 田中秀夫

ライフサポート学会大会講演予稿集　13th　92　1997/10

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Books and Other Publications 6

モデル動物の作製と利用 : 循環器疾患 2021

堀内, 久徳

エル・アイ・シー　2021/09

ISBN: 9784900487581
生命・医療・福祉ハンドブック

生命, 生体, 福祉研究所, d, 内山明彦, 梅津光生, 白石泰之ほか

コロナ社　2007/02/27
人工臓器で幸せですか？

梅津光生, 藤本哲男, 白石泰之, 岩崎清隆

コロナ社　2005/10/01
Lecture notes of the ICB Seminar on New Technologies for Future Artificial Organs

Nalez M Tsuchiya, K, ed. Shiraishi Y

Polska Akademia Nauk　2005/08/01
Lecture notes of the ICB Seminar on New Technologies for Future Artificial Organs

Umezu M Kawai, J, Suehiro J, Arita M, Shiraishi Y

Polska Akademia Nauk　2004/08/01
未来医学No.18「未来医学事典」

櫻井靖久, 白石泰之

日本医療企画　2003/04

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Presentations 69

Engineering Based Medicine〜心臓血管外科治療への工学的アプローチ〜

白石泰之

通研講演会第103回スピニクス研究会　2007/03/14
極小アクチュエータによる人工心筋の開発

白石泰之, 山家智之, 関根一光, 西條芳文, 金野敏, 仁田新一, 和田由美子, 坂田亮, 伊藤慎二, 植松美幸, 朴栄光, 田中隆, 梅津光生, 小川大祐, 角張泰之, 佐藤文博, 田中明

第35回人工心臓と補助循環懇話会　2007/03/07
消化管蠕動運動の補助を目的としたアクチュエータの開発研究

関根一光, 白石泰之, 山家智之, 西條芳文, 太田信, 堀義生, 松木英敏, 佐藤文博, 前田剛, 中澤文雄

日本機械学会第19回バイオエンジニアリング講演会　2007/01/09
生体心臓の構造を考慮した人工心筋開発の試み

白石泰之, 山家智之, 関根一光, 西條芳文ほか

日本機械学会第19回バイオエンジニアリング講演会　2007/01/09
形状記憶合金を応用した心室収縮補助装置の心臓に適合した設計

和田由美子, 白石泰之, 伊藤慎二, 坂田亮, 植松美幸, 田中隆, 朴栄光, 梅津光生, 関根一光, 金野敏, 西條芳文, 山家智之, 仁田新一, 田中明, 吉澤誠, 増本憲泰, 藤本哲男

日本機械学会第17回バイオフロンティア講演会　2006/11/16
脈診における脈波情報の取得に関する数学モデルの構築と実験による検証

鳴海賢太郎, 中西勉, 劉磊, 井上浩介, 白井敦, 早瀬敏幸, 太田信, 金野敏, 川田浩, 丸山満也, 白石泰之, 仁田新一

日本機械学会第17回バイオフロンティア講演会　2006/11/16
形状記憶合金を使用した蠕動運動アクチュエータの人工臓器としての可能性

関根一光, 白石泰之, 山家智之, 西條芳文, 堀義生, 松木英敏, 佐藤文博, 角張泰之, 三浦英和, 前田剛, 仁田新一

第44回日本人工臓器学会大会　2006/11/01
微細機能繊維を応用した機械式人工心筋お開発―心室補助効果と血管負荷整合

白石泰之, 山家智之, 西條芳文, 関根一光, 小川大祐, 佐藤文博, 角張泰之, 伊藤慎二, 坂田亮, 和田由美子, 田中隆, 梅津光生, 田林晄一, 比嘉昌, 田中明, 吉澤誠, 藤本哲

第44回日本人工臓器学会大会　2006/11/01
再生医療の評価方法としての高周波数超音波の可能性

西條芳文, 白石泰之, 関根一光, 山家智之, 佐藤博高, 萩原嘉広, 服部弘之, 田中明, 穂積直裕, 小林和人

第44回　2006/11/01
東北大学における無拍動流補助人工心臓EVAHEARTの長期動物実験による評価

王慶田, 山家智之, 白石泰之, 関根一光, 西條芳文, 仁田新一, 井街宏, 山崎健二, 北野智哉, 山崎俊一

第44回　2006/11/01
補助人工心臓用制御アルゴリズム開発のための循環系シミュレータ

笠原孝一郎, 田中明, 吉澤誠, 阿部健一, Olegario Paul, 小川大祐, 白石泰之, 関根一光, 山家智之, 仁田新一

第44回　2006/11/01
定常流型補助人工心臓装着時の新機能評価・動物実験およびモデルによる検討

小川大祐, 田中明, 吉澤誠, 阿部健一, Olegario Paul, 笠原孝一郎, 白石泰之, 関根一光, 山家智之, 仁田新一

第44回　2006/11/01
長期埋込型形状記憶合金人工括約筋の生体適合性評価

劉紅箭, 羅雲, 比嘉昌, 西條芳文, 白石泰之, 関根一光, 山家智之

第44回　2006/11/01
形状記憶合金を応用した人工心筋要素の機械特性と駆動制御に関する基礎検討

伊藤慎二, 白石泰之, 和田由美子, 坂田亮, 植松美幸, 田中隆, 小川大祐, 関根一光, 吉澤誠, 田中明, 西條芳文, 山家智之, 岡本英治, 本間大, 藤本哲男, 梅津光生

第44回　2006/11/01
Preliminary study on the functional reproduction of an artificial myocardium using covalent shape memory alloy fibre based on control engineering International-presentation

Shiraishi Y, Yambe T, Sekine K, Saijo Y, Konno D, Nitta S, Wang Q, Liu H

SICE-ICASE Int Joint Cof 2006　2006/10/19
Preliminary study on the cardiac functional reproduction by mechanical elements International-presentation

Itoh S, Shiraishi Y, Yambe T, Umezu M

SMEBA　2006/09/15
Support mechanism of a newly-designed mechanical artificial myocardium using shape memory alloy fibres International-presentation

Shiraishi Y, Yambe T, Sekine K, Saijo Y, Konno S, Sato F, Nitta S, Itoh S, Fujimoto T, Umezu M, Tabayashi K

WC2006　2006/08/28
Development of an artificial myocardium using covalent-type shape memory alloy fibres International-presentation

Shiraishi Y

IFMBE Inaugural Asia-Pacific Traveling Fellowship in Biomedilcal Engineering Seminar　2006/08/26
Hemodynamic evaluation of artificial abdominal grafts in a sophisticated mechanical circulatory system International-presentation

Shiraishi Y

Asia-Pacific Traveling Fellows -IFMBE Working Group for Asia-Pacific Activities- Seminar in Tainan　2006/08/23
Hemodynamic evaluation of artificial abdominal grafts in a sophisticated mechanical circulatory system International-presentation

Shiraishi Y

Asia-Pacific Traveling Fellows -IFMBE Working Group for Asia-Pacific Activities- Seminar in HongKong　2006/08/21
Hemodynamic evaluation of artificial abdominal grafts in a sophisticated mechanical circulatory system International-presentation

Shiraishi Y

Asia-Pacific Traveling Fellows -IFMBE Working Group for Asia-Pacific Activities- Seminar　2006/08/18
Development of an artificial myocardial assist device using a sophisticated shape memory alloy fibre (Biometal) International-presentation

Shiraishi Y, Yambe T, Saijo Y, Sekine K, Nitta S, Itoh S, Umezu M, Homma D, Yamaguchi K

3rd World Congress on Biomimetics, Artificial Muscles & Nano-Bio　2006/08/12
バイオエンジニアリングによる人工血管性能評価および手術支援

白石泰之, 梅津光生

第10回日本適応医学会　2006/06/23
Mechanical effect of an artificial myocardium on the left ventricular pressure-volume relationship International-presentation

Shiraishi Y, Yambe T, Sekine K, Saijo Y, Konno S, Wang Q, Liu H, Nitta S

XXXIII Congress of ESAO　2006/06/21
Development of an implantable undulation pump VAD International-presentation

Imachi K, Abe Y, Saito I, Chinzei T, Yambe T, Takiura K, Shiraishi Y

XXXIII Congress of ESAO　2006/06/21
Application of artificial peristaltic actuator for the esophageal stent International-presentation

Sekine K, Yambe T, Hori Y, Shiraishi Y, Saijo Y, Matsuki H, Sato F, Kakubari Y, Miura H, Liu H, Wang Q, Marda T

XXXIII Congress of ESAO　2006/06/21
Usefulness of nano technology for the development of the artificial internal organs International-presentation

Yambe T, Shiraishi Y, Sekine K, Hori Y, Haga Y

XXXIII Congress of ESAO　2006/06/21
Characteristics of a newly designed aortofemoral prosthetic Y graft under pulsatile flow conditions International-presentation

Fujimoto T, Nakano S, Iwamura H, Shiraishi Y, Yambe T, Umezu M

XXXIII Congress of ESAO　2006/06/21
Drinking esophageal stent with therapeutic hyperthermia effect for the cancer International-presentation

Yambe T, Hori Y, Shiraishi Y, Sekine K, Miyata G

XXXIII Congress of ESAO　2006/06/21
Hemodynamic evaluation of artificial abdominal grafts in a sophisticated mechanical circulatory system

Shiraishi Y, Sekine K, Yambe T, Saijo Y, Iwamura H, Obitsu Y, Uematsu M, Fujimoto T, Nitta S, Umezu M

TFI2006　2006/06/17
微細形状記憶合金を用いた機械式人工心筋による血行力学的効果の検討

白石泰之, 山家智之, 西條芳文ほか

第45回日本生体医工学会　2006/05/23
橈骨動脈脈波における尺骨動脈血流の影響についての循環モデルによる検討

金野敏, 丸山満也, 仁田新一, 高島充, 白石泰之, 山家智之, 太田信, 劉磊, 鳴海健太郎, 白井敦, 早瀬敏幸, 吉澤誠

第45回日本生体医工学会　2006/05/23
定常流補助人工心臓を考慮した心機能評価法の検討

小川大祐, 田中明, 阿部健一, Paul Olegario, 笠原考一郎, 白石泰之, 関根一光, 山家智之, 仁田新一, 吉澤誠

第45回日本生体医工学会　2006/05/23
蠕動運動機能を有する生体内埋め込み可能な人工食道の開発研究

関根一光, 山家智之, 西條芳文, 白石泰之, 堀義生, 松木英敏, 佐藤文博, 角張泰之, 三浦英和

第45回日本生体医工学会　2006/05/23
経食道心エコーによる左室補助装置装着患者の心機能評価

西條芳文, 齋木佳克, 井口篤志, 田林晄一, 白石泰之, 関根一光, 山家智之

第45回日本生体医工学会　2006/05/23
定常流型補助人工心臓は定常流として解析すべきでない

吉澤誠, 田中明, ポールオレガリオ, 小川大祐, 笠原考一郎, 阿部健一, 白石泰之, 山家智之, 仁田新一

第45回日本生体医工学会　2006/05/23
Artificial internal organs by the use of artificial muscle International-presentation

Yambe T, Sekine K, Shiraishi Y, Saijo Y, Imachi K, Yamaguchi K, Maeda T

3rd World Congress on Biomimetics, Artificial Muscles & Nano-Bio　2006/05/12
機械要素による人工的心筋機能再生の試み

白石泰之, 関根一光, 西條芳文, 山家智之, 劉紅箭ほか

第3回東北大学バイオサイエンスシンポジウム　2006/05/07
形状記憶合金を応用した新しい心室収縮補助装置の開発

永利潤, 白石泰之ほか

第16回日本機械学会バイオフロンティア講演会　2005/11/12
新田能郎，西條芳文，白石泰之，山家智之，若松立也，田中元直，田林晄一

冠動脈バイパスグラフトの術中評価, マルチポイントドプラ法, 機器の開発

第43回日本人工臓器学会大会　2005/11/12
粘弾性効果を考慮したin vivoにおける大腸の力学的特性評価試験

比嘉昌, 羅雲, 奥山武志, 高木敏行, 白石泰之, 山家智之

第43回　2005/11/12
コイル状形状記憶合金による蠕動運動型人工食道の開発

関根一光, 山家智之, 西條芳文, 白石泰之, 堀義生, 松木英敏, 佐藤文博, 角張泰之, 三浦英和, 前田剛, 仁田新一

第43回　2005/11/12
超微細径アクチュエータを用いたメカトロニクス心筋の開発

白石泰之, 山家智之, 西條芳文ほか

第43回　2005/11/12
波動型補助人工心臓用高効率経皮的電力伝送システムの開発

三浦英和, 荒井真輔, 角張泰之, 佐藤文博, 斎藤逸郎, 井上雄介, 磯山隆, 鎮西恒雄, 阿部裕輔, 瀧浦晃基, 牧野勤, 望月修一, 白石泰之, 関根一光, 岡本英治, 山家智之

第43回　2005/11/12
補助人工心臓用定常流ポンプ装着時の心機能評価法の検討

小川大祐, 田中明, 阿部健一, Olegario Paul, 笠原孝一郎, 白石泰之, 関根一光, 山家智之, 仁田新一, 吉澤誠

第43回　2005/11/12
異なる2つのタイプの分岐型人工血管のPWVを用いた比較

岩橋徹, 内山裕智, 中村慶太, 佐藤和弘, 小泉信達, 張益商, 小櫃由樹生, 白石泰之

第43回日本人工臓器学会大会　2005/11/12
Development of a newly-designed artificial myocardial assist device using biometal International-presentation

Y. Shiraishi, T. Yambe, Saijo Y

ESAO XXXII Congress　2005/10/12
Development of moving esophageal stent using artificial peristaltic motion International-presentation

Sekine K, Shiraishi Y, Yambe T

ESAO XXXII Congress　2005/10/12
Influence of blood flow waveform created by UPVAD on endocardial viability ratio and myocardial tissue perfusion International-presentation

K. Sekine, T. Yambe, Y. Saijo, Y. Shiraishi Y

ESAO XXXII Congress　2005/10/12
小さな機械で心筋をサポートするシステム？完全埋込型エレクトロハイドローリック方式心室補助装置の具現化？

白石泰之ほか

第33回人工心臓と補助循環懇話会　2005/01/12
完全埋込型心室補助装置による循環補助

白石泰之ほか

日本エム・イー学会東北支部大会　2004/10/23
Preliminary study on evaluation of the hemodynamic function of a totally implantable artificail electrohydraulic myocardium International-presentation

Y. Shiraishi, T. Yambe, Y. Saijo

Heart Failure & Rotary Blood Pump Summit　2004/10/17
血液循環シミュレーションモデルによる透析シャント用ePTFE人工血管の拍動抵抗特性の比較

白石泰之, 関根一光, 山家智之, 青木秀宜, 梅津光生, 藤本哲男, 内野敬

第42回日本人工臓器学会大会　2004/10/05
完全埋込を目指した人工心室補助装置の血行力学的影響〜慢性動物実験における心収縮補助効果の検討〜

白石泰之, 山家智之, 関根一光, 西條芳文ほか

第42回日本人工臓器学会大会　2004/10/05
Artificial baroreflex and fluctuations in rotary blood pump International-presentation

Yambe T, Abe Y, Yoshizawa M, Shiraishi Y, Sekine K, Imachi K, Nitta S

XXXI Annual ESAO Congress　2004/09/11
Hemodynamic effect of the left or right ventricular assistance by a mechanical myocardial assist system International-presentation

Shiraishi Y

XXXI Annual ESAO Congress　2004/09/11
Development of a coronary mock simulator to evaluate the effectiveness of coronary arterial bypass grafting anastomosis International-presentation

Umezu M, Shiraishi Y

XXXI Annual ESAO Congress　2004/09/11
Nano technology for the artificial myocardium International-presentation

Yambe T, Shiraishi Y, Sekine K, Hori Y, Luo Y, Maruyama S, Takagi T, Esashi M, Haga Y, Yoshizawa M, Sato F, Matsuki H, Saijo Y, Nitta S

XXXI Annual ESAO Congress　2004/09/11
Supporting effect of the implantable undulation pump ventricular assist device on ischemic heart failure International-presentation

Yambe T, Shiraishi Y, Abe Y, Imachi K, Saito I, Mochizuki S, Mitamura Y, Umezu M, Matsuda T, Okamoto E, Nitta S

XXXI Annual ESAO Congress　2004/09/11
Development of an artificial myocardial assist system International-presentation

Shiraishi Y, Yambe T, Okamoto E, Saijo Y, Sekine K, Hori Y, Kuwayama T, Olegario P, Tanaka A, Yoshizawa M, Wang Q, Duan X, Liu H, Aoki H, Nagatoshi J, Ito S, Umezu M, Tabayashi K, Sasada H

76th ICB Seminar: 7th Polish-Japanese Seminar on New technologies for future artificial Organs　2004/09/01
Biomedical engineering analysis on the effectiveness of cardiovascular surgery: anastomosis methods for coronary artery bypass grafting International-presentation

Umezu M, Kawai J, Suehiro J, Arita M, Shiraishi Y, Iwasaki K, Tanaka T, Niinami H

76th ICB Seminar: 7th Polish-Japanese Seminar on New technologies for future artificial Organs　2004/09/01
Development of peristaltic artificial esophagus International-presentation

Sekine K, Hori Y, Shiraishi Y, Saijo Y, Wang Q, Duan X, Liu H, Matsuki H, Sato F, Maeda T, Yambe T

XXXI Annual ESAO Congress　2004/08/12
A newly-designed myocardial assist device using a sophisticated shape memory alloy fibre International-presentation

Shiraishi Y, Yambe T, Saijo Y

8th Japan-Polish BME Seminar　2004/08/12
Development of peristaltic artificial esophagus International-presentation

Sekine K, Hori Y, Shiraishi Y, Saijo Y, Wang Q, Duan X, Liu H, Matsuki H, Sato F, Maeda T, Yambe T

XXXI Annual ESAO Congress　2004/08/11
Multi-institutional cooperative project to develop an implantable VAD International-presentation

Imachi K, Takiura K, Yambe T, Saijo Y, Shiraishi Y, Sekine K, Nitta S

76th ICB Seminar: 7th Polish-Japanese Seminar on New technologies for future artificial Organs　2004/08/01
Development of an integrative artificial myocardial assist device using nano-devices: Preliminary study on the hemodynamic effects of mechanical ventricular assistance in goat International-presentation

Y. Shiraishi

Tohoku Uni COE International Sympo　2004/06/26
人工心筋を用いた心機能補助時の左心室壁に対する影響の検討

白石泰之ほか

第43回日本エム・イー学会　2004/05/23
心臓の収縮を補助する人工心筋システムの開発

白石泰之ほか

第1回東北バイオサイエンスシンポジウム　2004/05/07
機械式心室補助装置による局所的心筋補助方法の検討

白石泰之, 山家智之, 永利潤, 青木秀宜, 段旭東, 王慶田, 柴田宗一, 山口済, 西條芳文, 劉紅箭, 洪蘭, 沙樹偉, 仁田新一, 田中明, 吉澤誠, 小川大祐, ポールオレガ

第32回人工心臓と補助循環懇話会　2004/01/28

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Industrial Property Rights 2

人工舌用又は舌部植込型アクチュエータ、人工舌、人工舌システム

山家智之, 香取幸夫, 川瀬哲明, 山内大輔, 加藤健吾, 白石泰之ほか

特許6796860

Property Type: Patent
味覚評価診断装置

山家智之, 白石泰之ほか

特許6692110

Property Type: Patent

Research Projects 27

Development of a platform for evaluating the environmental response to von Willebrand factor during circulatory assist

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2024/04/01 - 2027/03/31
Platform design for von Willebrand factor response evaluation in circulatory support

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2022/04/01 - 2027/03/31
Development of the ventricular assist device that can be started within 3 min

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Challenging Research (Exploratory)

Institution: Tohoku University

2023/06/30 - 2025/03/31
Design analysis for paediatric pulmonary heart valve in low Raynolds number hemodynamics with high speed imaging

Shiraishi Yasuyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2019/04/01 - 2022/03/31

More details Close

The aim of this study was to evaluate the right ventricular circulatory system for the novel diagnostic analysis simulator with expanded polytetrafluoroethylene (ePTFE) trileaflet pulmonary heart valves by using a high-speed dynamic analysis with digital image correlation (DIC). The pulmonary ePTFE heart valve leaflet dynamic behaviour was affected by low Reynolds number fluid characteristics. The results showed the maximum 3D reconstruction error to be around 0.06 mm. In the steady flow test, the evaluation of opening angles under the different flow rate conditions was achieved. In the pulsatile flow test, each leaflet's opening and closing behaviours were successfully reconstructed simultaneously at the high-frequency recording rate of 960fps. Therefore, the system developed in this study confirms the design evaluation method of an ePTFE valved conduit behaviour with leaflet structures interacting with local fluid dynamics in the vicinity of valves.
Mechanical Modeling of Pulmonary Vascular Resistance Based on Hemodynamic Masurements Competitive

Yusuke TSUBOKO, Yasuyuki Shiraishi

Offer Organization: Institute of Development, Aging and Cancer, Tohoku University

System: Joint Research Program of Joint Usage/Research Center at the Institute of Development, Aging and Cancer, Tohoku University

Institution: Waseda University

2018/04 - 2019/03
Parients' Self-contorol hypertension therapeutic devise

Yambe Tomoyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2013/04/01 - 2018/03/31

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The aim of this invention is the development of the totally implantable hypertension control machine, which will be able to be used by the patients themselves. For that purpose, hypertension control machine was composed with the implantable renal nerve cooling device using Peltier elements, the secondary coil with control system, and the first coil placed outside of the human body. The results of our study showed the sucessful invention of the renal nerve control system.
Establishtment of biomedical network platform for the development for paediatric circultory support system(Fostering Joint International Research)

Shiraishi Yasuyuki, Qian Yi, Narracott Andrew James, Fenner John, Rod Hose Pat Lawford, Diaz Vanessa, Yamagishi Masaaki, Yambe Tomoyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Institution: Tohoku University

2016 - 2018

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The development of innovative circulatory support systems for paediatric congenital heart failure patients is highly needed because they still poses a unique set of challenges, despite successfull advances in cardiovascular surgical treatment with artificial organs for adult patients. The present project exhibited the integrated research and development of an artifical pulmonary heart valve conduit and a right ventricualr circulatory support device based on the international biomedical and medical physics approaches with Macquarie University in Australia and the University of Sheffiled in the UK. Consequently, the fluid dynamics evaluation for complicated structural flow analysis based on the vascular wall-fluid structure and the valve leaflet numerical reconstraction for dynamic analysis were achieved for more sophisticated congenital circualtory support device design.
Modelling of peripheral perfusion during mechanical circulatory system support

Shiraishi Yasuyuki, MIURA HIDEKAZU, YAMBE TOMOYUKI, SASAKI KAZUMASU, AKIYAMA MASATOSHI, SAIKI YOSHIKATSU

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2014/04/01 - 2016/03/31

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There is an increasing number of domiciliary treatment cases of patients with severe heart failure. However, it is anticipated that the deterioration of peripheral organs might be caused by the long-term rotary blood pump support. We focused on the development of a new diagnostic method for the evaluation of peripheral perfusion using a simple non-invasive imaging. By the method designed, the colour level of intensity showed blood flow perfusion which could be validated in goats’ experiments with the laser Doppler flow velocimetry. Secondly, we examined the effect of mechanical circulatory assistance ratio on peripheral perfusion by the changes in revolution numbers during the left ventricular support using a centrifugal blood pump that was connected from the apex to the descending aorta. As a result, it was indicated the system designed in the study could be useful for the evaluation of peripheral circulatory condition during mechanical circulatory support.
Total Artificial Heart using Anatomically Compatible Helical Inflow Centrifugal Blood Pumps

Miura Hidekazu, SHIRAISHI Yasuyuki, YAMBE Tomoyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Young Scientists (B)

Institution: Tohoku University

2013/04/01 - 2016/03/31

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In an acute animal experiment, the total artificial circulation model was made using the centrifugal type after marketing ,left ventricular assist devices, the regular way, an achieved possibility of the centrifugal type blood pump total artificial heart was indicated. An atrium pulse was kept in the total artificial heart animal experiment model, and we found that physiological control by automatic nerves system control might be achieved. A concept model of the total artificial heart was made using a three-dimensional printer and fitting study was performed in adult goats of sacrifice after the other experiments. The independent left and right blood pumps type total artificial heart concept of was indicated by miniaturizing the blood pumps. It was low in cost and a small embroidered design in one constraint ball bearing aiming longer durability was contrived and the movement was confirmed in a prototype pump.
Arrythmia control device controlled by the patients

Yambe Tomoyuki, SHIRAISHI YASUYUKI, MYURA HIDEKAZU, YOSHIZAWA MAKOTO

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2013/04/01 - 2016/03/31

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The aim of this study is the development of the totally implantable arrythmia control device, which will be controlles by the patients. In the Sendai quake, a lot of patients had arrhtmia and cardiovascular events. If we have arrthmia control device, it will good news for the patients. Arrthysmia control device was invented in this grants and patent was offered to the patent office.
Impact of sinus Valsalva formation in valved conduits on prosthetic valve function placed in low pressure circulatory system; an ex-vivo comparative study

SAI Sadahiro, SAIKI Yoshikatsu, MOTOYOSHI Naotaka, AKIYAMA Masatoshi, YAMBE Tomoyuki, SHIRAISHI Yasuyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2013/04/01 - 2016/03/31

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The aim of this study is to elucidate a role of sinus Valsalva in a low pressure circulatory system by comparing hemodynamic performance of tested prosthetic valves in a composite graft with or without sinus formation. Composite grafts consisted of Dacron grafts with or without sinus formation incorporated with commercially available prosthetic valves (one type of mechanical valves and 2 bioprosthetic valves) were prepared. Mock circulation was constructed so as to replicate the low pressure circulatory system. Vortex flow was observed by an overhang part corresponding to a Valsalva sinus by echodynamography in all valves. When the sinus was present, decreased energy loss was obtained and the opening performance of valve was improved in one of the bioprosthetic valves. However regurgitant flow was increased by the presence of the sinus in all valves. It is further necessary to evaluate the movement of leaflet in order to investigate these phenomena.
Mechanical circulatory support system development platform for congenital heart diseases using a small implantable actuator

Shiraishi Yasuyuki, MIURA HIDEKAZU, YAMBE TOMOYUKI, SASAKI KAZUMASU, YAMAGISHI MASAAKI, AKIYAMA MASATOSHI, SAIKI YOSHIKATSU

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2013/04/01 - 2016/03/31

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Long-term mechanical support systems development resources are needed for the surgical treatment of congenital heart failure. We employed a small-sized nano-tech Ni-Ti shape memory alloy fibre as an implantable actuator for the mechanical circulatory support. We focused on the development of two types of implantable devices; a) a right ventricular external contraction support belt, and b) a Fontan circulation active support system that could be used with the total cavopulmonary connection. We examined the systems function in the originally designed mock circulatory system with a silicone-rubber right ventricular model as well as in the animal models. As a result of this study, it was indicated that the micro actuation system for congenital heart failure support could be useful to exhibit the hemodynamic effect for the totally implantable system design.
Development of an artificial papillary muscle recovering left ventricular functions

SHIRAISHI Yasuyuki, YAMBE Tomoyuki, MIURA Hidekazu, UMEZU Mitsuo, HOMMA Dai

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2011 - 2012

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We developed an artificial papillary muscle by using covalent-type Ni-Ti anisotropic shape memory fibres. We could achieve the development of a tissue-rubber hybrid left ventricular model including native heart valves. Subsequently we could investigate optimised mechanical interactions between mitral valve leaflets and the left ventricle with the artificial papillary muscle reducing mitral valve regurgitation.
Development of an artificial myocardial assist system for paediatric heart diseases

SHIRAISHI Yasuyuki, YAMBE Tomoyuki, YAMAGISHI Masaaki, MORITA Kiyozo, HOMMA DAI

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Young Scientists (A)

Institution: Tohoku University

2010 - 2012

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We have developed paediatric myocardial and circulatory assist systems as an alternative surgical treatment for congenital heart diseases. A covalent-type anisotropic Ni-Ti alloy fibre was employed as the actuator for the totally-implantable circulatory assist system which could be clinically applied for small sized patients. Subsequently, the two types of assisted circulation system, a) a contractile extra cardiac conduit for Fontan procedures, and b) a ventricular pouch support system were implemented based on the hemodynamic and thermodynamic control.
新たな自律神経情報解析法と薬効評価モデルの開発研究

劉紅箭, 山家智之, 白石泰之, 三浦英和

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 挑戦的萌芽研究

Institution: 東北大学

2011 - 2011

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自律神経系活動の情報を得るために、現在心拍のパワースペクトル解析法による非侵襲的な測定方法がよく利用されている。この解析方法によって、高周波数および低周波数成分の変化に基づいて、交感神経と副交感神経の総合的な活動を評価することができる。低周波成分を示す交感神経活動にはβ受容体交感神経活動とα受容体交感神経活動などが含まれるため、従来の方法では複雑な合成波を解釈していたことになる。したがって、これらの受容体の種類に特異的な周波数スペクトルを同定することにより、個々の受容体の活動を非侵襲的に計測することが可能になる。種々の循環器疾患に対して、その発病のメカニズムの研究と自律神経のシグナル伝達経路の情報、治療方案の選択と治療効果の評価、病気の予防と予後、遺伝子多型の研究および新薬の開発が大きく期待され、複合波の分離ができることにより正確な情報量を見出せる新しい解析法の開発は不可欠である。循環系信号の周期と非周期変化の受容体交感神経活動のメカニズムを明らかにするために、健常成山羊を用いて塩酸メキサン静注により、心電図及び大動脈圧波形は、デジタルレコーダによって1kHzのサンプリング周波数で同時記録した。RR間隔及び大動脈圧変動は、3次スプライン関数を用いて補間し再サンプリングを行い、それぞれ周波数解析を行った。周波数解析によって0.15-0.40Hzの高周波成分(HF)及び0.04-0.15Hzの低周波数成分(LF)を主成分とする要素に分解した。メキサン投与10分後の心拍数と大動脈圧のLF、HFおよびLF/HF変化から、交感神経-副交感神経の制御バランスが変動し、循環動態に対する外乱への積極的な応答が有意に認められた。また、薬物負荷による血管抵抗変化に対する心拍応答特性にも示された。心拍変動と動脈圧、圧受容体および循環中枢が相互に複雑なフィードバックループを形成しており、これが一種の複雑系として考えられる。
リアクティブ心臓モデリングによる心不全メカニクスの徹底解明

白石泰之, 山家智之

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 挑戦的萌芽研究

Institution: 東北大学

2008 - 2009

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心室形成術や、補助循環施行時に経験的には説明のしづらい心不全病態生理の変化が起こる。これらに対して、本研究は、微細形状記憶合金線維を利用して人工心筋開発技術を基盤として、3次元のリアクティブ挙動が可能な心臓モデルを開発し、科学的データを提示することを目的とする。本研究で開発に挑戦する装置は、超小型のマイクロマシン化した機械式アクチュエータを集積し、心臓の病態を3次元検査データに基づいて精密に再現し、さらに拍動を伴って心不全のメカニクスを動的に提示するものである。このシステムは、生体心臓のMRIデータに基づいて迅速にローコストで術前の形態を機械的に再構築し、心筋の解剖学的構造を模擬した駆動メカニズムを組み込むことで、循環生理学的知見に基づくロボット工学を応用した制御を行い、外部からの形成による変形にリアクティブに対応する。本年度は、とくに病態モデルのメカニクス解析とそのその結果を昨年度までに構築した機械的モデルへの融合を試み、リアクティブ心臓モデルの基本構造設計および作成法の検討を進めた。結果として、(a)動物実験による心臓解剖学的構造及び心筋走向の数値的再構築、(b)人工心筋の基盤技術を応用した可観測の収縮アクチュエータの開発、(c)外科治療の直前術前評価を可能とする解析情報融合化タンジブルモデルを具現化した。臨床ニーズと対照させ、患者個々の心不全病態に対して客観的かつ定量的な心筋メカニクス解析結果を重畳したシステムの利用が可能となった。
Development of a passive-active artificialmyocardium reconcilingthe physiological demands with hemodynamic changes

SHIRAISHI Yasuyuki, YAMBE Tomoyuki, SAIJO Yoshifumi, UMEZU Mitsuo, FUJIMOTO Tetsuo, BABA Atsushi, TABAYASHI Koichi, HOMMA Dai

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Young Scientists (A)

Institution: Tohoku University

2007 - 2009

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We developed a sophisticated artificial myocardium which consisted of shape memory alloy fibre units. We applied the PID method for the control of myocardial assist, and examined the dynamic performance as well as hemodynamic changes in goats. It was anticipated that the passive-active artificial myocardium control could be achieved which was reconciling the physiological demands with pathophysiological diagnosis by using our new methodology.
患者自身で発作をコントロールできる完全埋込型てんかん発作制御装置の開発

山家智之, 圓山重直, 白石泰之, 佐藤文博

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 挑戦的萌芽研究

Institution: 東北大学

2007 - 2009

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本研究計画の目的は、全世界の人口の0.5～1.5%(約六千万人前後)の有病率を持つと報告される全人類にとっても最も重要な疾患の一つである「てんかん」の発作を、患者が自分で発作をコントロールすることができる全く新しい人工内臓「完全埋込型てんかん発作停止装置」の開発である。そのために、外科的な病巣切除とは根本的に異なる安全な治療方法としてのナノテク経皮伝送技術などを応用したてんかん発作停止装置の発明に至り、東北大学、ミシガン大学などと協同で、既に特許申請も行った(特願2005-291008)。システムは、ペルチェ素子等の電子冷却素子等を応用した体内冷却部とヒートシンクでナノレベル最適熱設計を行ったてんかん停止装置本体、装置にエネルギーを供給する経皮エネルギー伝送システム、及びナノDLCセンサ等を用いたコントローラとしてのてんかん発作診断装置より構成される。最適熱設計により病巣の最適の冷却を行うことができ、電子冷却素子では必ず問題となる反対側の熱の発生も、経皮エネルギー伝送システムを兼ねた対側のヒートシンクの最適熱設計によって完全に予防できる極めて安全性が高いシステムである。試作したシステムは、体外の一次コイル及び電源ユニット、皮下にペースメーカのように埋め込まれる二次コイルを兼ねた精密な熱設計計算を行って熱放散を最小に最適化したヒートシンク、及びてんかんの焦点である病巣を冷却するペルチェ素子などを応用した電子冷却素子デバイスから構成され、冷却素子デバイスは、小切開を介して頭蓋内に一部挿入され、病巣を冷却する。ヒートシンクを兼ねた二次コイルは、頭蓋骨外でペースメーカのように皮下に置かれる。この方法論に採用により、最小限の侵襲でデバイスの埋め込みが可能になる。更に、デバイスは頭蓋骨に固定されるので、脳組織を傷害させる危険は極めて少ない安全性の高いものとなった。
Comprehensive basic study on optimum flow condition of total artificial heart from the view point of microcirculation

IMACHI Kou, YANBE Tomoyuki, SHIRAISHI Yasuyuki, ABE Yusuke, ISOYAMA Takashi, SAITO Itsuro, BABA Atsushi, TAKIURA Kouki, MOCHIZUKI Shuichi, VASKU Jaromir, DOBSAK Petr, KOUNO Akimasa, ONO Toshiya, INOUE Yausuke

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (A)

Institution: Tohoku University

2006 - 2009

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It was succeeded to develop the following research tools to clarify the influences of flow dynamic states of total artificial heart such as pulsatile flow, continuous flow, etc. on microcirculation of the living body ; 1) Undulation pump total artificial heart that was enough compact to be implanted into the chest cavity of a goat weighing 40Kg and could generate any style of flow waveform, was developed. 2) A microcirculation probe that could be implanted into the body and observe continuously the microcirculation in the peripheral system without a microscope was developed. 3) These systems were implanted into goats chronically. The longest implantation period was 153 days and the difference between pulsatile and continuous flow on the living body including microcirculation was analysed during this period.
Development of the bio-robotics artificial myocardium Competitive

System: Grant-in-Aid for Scientific Research

2005/04 - 2008/03
Development of newly designed pressure sensor for regenerative medicine and artificial organs

FUJIMOTO Tetsuo, UMEZU Mitsuo, NISHIDA Hiroshi, SHIMIZU Tatsuya, SHIRAISHI Yasuyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Shibaura Institute of Technology

2006 - 2008
Clinical evaluation of a noninvasive estimation system for cardiac function

YOSHIZAWA Makoto, NITTA Shinichi, YAMBE Tomoyuki, SAIJO Yoshifumi, TANAKA Akira, SHIRAISHI Yasuyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2006 - 2008
Development of the peristaltic nano-tech artificial esophageal stent Competitive

2004/04 - 2006/09
Development of the totally implantable artificial myocardial assist device Competitive

System: Health and Labour Sciences Research Grants

2002/10 - 2004/03
1ヶ月保証の超低価格血液ポンプの実用化を阻む要素の徹低解明

岩崎清隆, 桜井靖久, 梅津光生, 石原一彦, 白石泰之, 岩崎清隆, 北村信夫

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 萌芽研究

Institution: 早稲田大学

2002 - 2004

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補助人工心臓は重症心不全患者に対して有効な治療手段であるが,高価格であり,またその利用が高度先進医療施設に限定されることから適用数は極めて少ない.このため,急性心不全といった短期間での回復が期待される症例に対しては,有効な医療デバイスが国内において存在しない現状にある.本最終年度は,真空成形法により大量生産技術を確立した旋回渦流型拍動血液ポンプを基盤とし,どの市中病院でもほぼ常備している大動脈バルーンパンピング用駆動装置(IABP駆動装置)を流用して臨床で要求される性能を満足すべく,駆動装置のアタッチメントを開発した.あわせて,カニューレのプロトタイプを作製してポンプシステムとしての総合的性能を明確化した.IABP駆動装置を用いた際には,人工心臓用駆動装置と比較して1.5倍の溶血量が生じることが判明した.この原因として,IABP駆動装置による駆動圧力波形の急激な変化による血球へのダメージが考えられた.そこで,駆動圧の最大,最小圧及びdP/dtを低減させること目的に,ニードル弁・圧力タンクで構成する一次遅れ系要素を応用した圧力制御ユニットを開発した.このユニットをポンプと駆動装置の間に接続するだけで,ポンプの拍出量は維持したまま駆動陽・陰圧をそれぞれ32%,55%減少させることができた.さらに,人工心臓用駆動装置を用いた場合と比較して溶血量を7.4%減少させることに成功した.あわせて,患者の精神的負担と感染リスクを低減させることを目的とし,内径が体外部19mm,皮膚貫通部10mm,体内部12mmという皮膚貫通部のみを細径化したカニューレを設計・製作して性能試験を行った.その結果,本ポンプシステムで5L/minを超える平均流量の確保が可能であることが判明し,各要素の開発はほぼ完了した.今後,動物実験を行い,解剖学的フィッティングを包括してカニューレを開発する必要がある.
Evaluation of the cardiac load after the vascular graft surgery by using a sophisticated mock circulatory system Competitive

System: Grant-in-Aid for Scientific Research

2001/04 - 2002/09
人工血管置換による血行動態変化の工学的解析評価システムの開発

白石泰之

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 若手研究(B)

Institution: 早稲田大学

2001 - 2002

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昨年度までに患者の手術を想定した動物実験により主要大動脈部位の人工血管による置換前後の血行動態データの取得を行った.本年度はこれらの生体データを参照し,人工血管置換手術の工学的解析評価システムの構築・開発研究を進めた.設計開発を行った血液循環シミュレータでは,体重40〜50kg程度の成人の心臓および動脈内の圧力流量特性を高度に模擬することを目的とし,生体血液循環系と機械工学における流体回路系のアナロジを用いて回路内各要素を設計・製作した.このシミュレータは,形状を模擬した左心房・左心室モデルとテーパ及び分岐を有する大動脈弓形状を高度に模擬した高分子弾性管製大動脈モデル,また中小動脈における血管抵抗を集中定数化しサーボ機構による抵抗制御を行うことが可能な末梢抵抗装置・肺静脈を模擬したオーバーフロータンクから構成される.左心室モデルの駆動には,自然心臓における心臓収縮機能(Emax)を再現するアクチュエータを用い,人工血管置換による動脈血管系の特性変化と心臓-血管系の力学的整合について工学的観点から外科手術における患者の心機能への影響を定量化することを試みた.さらに,臨床における大動脈疾患の外科手術適応患者には高齢者が多いことを考慮し,開発した血液循環シミュレータにおいても高齢者特有の血行力学的データを再現できるシステムの設計方法についても検討を行い,血管の粘弾性特性を新たな手法を用いて数式モデルにより解析した.それらのデータに基づいてシミュレータ動脈血管系要素の力学パラメータを変動させることにより作動流体の圧流量特性を任意に可変とするシステムができた.治療効果の予測システムには,患者の個体差と生体の力学的適応も考慮されることが望まれるが,本研究の設計開発手法をさらに展開することにより,ナノテクノロジーや組織工学を利用した次世代の人工臓器開発設計・評価にも応用できると考えられる.

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Social Activities 1

[日本国内] ザ・ベストハウス123「すごいワイヤ・人工心筋」

2008/04/09 -

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形状記憶合金を応用した人工心筋の紹介。

Media Coverage 3

人工舌、自然に動き食事補助

日経産業新聞　日経産業新聞

2021/01/15

Type: Newspaper, magazine
嚥下機能を非接触で評価

日本歯科新聞　日本歯科新聞

2020/08/14

Type: Newspaper, magazine
[日本国内] 「人工心筋、拍動保つ命綱」

日経産業新聞

2007/08/07

Type: Newspaper, magazine

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人工心筋開発の現況紹介

Other 7

1施設1台：富山の常備薬型補助心臓の実用化

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1施設1台：富山の常備薬型補助心臓の実用化
マイクロロボティクスを応用したナノテク心筋の開発

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マイクロロボティクスを応用したナノテク心筋の開発
先端医療実現のための医工学的研究

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先端医療実現のための医工学的研究
波動型人工心臓の実用化のための総合的研究：生体情報による人工心臓と内臓機能の制御方法の確立と経皮エネルギ伝送システムの開発に関する研究

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波動型人工心臓の実用化のための総合的研究：生体情報による人工心臓と内臓機能の制御方法の確立と経皮エネルギ伝送システムの開発に関する研究
ナノテク集積型埋め込み式心室補助装置

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ナノテク集積型埋め込み式心室補助装置
人工臓器・ME機器の先進機器への応用研究

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人工臓器・ME機器の先進機器への応用研究
生命・生体・福祉に関する研究

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生命・生体・福祉に関する研究

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